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1

TILT Following a TFCC Tear: A Case Report  

PubMed Central

We describe the case of a dorsal proximal triquetral impingement caused by a torn triangular fibrocartilage complex (TFCC) amassed on the repair site at the ulnar styloid. The impinging tissue was removed by simple burring with resultant relief of symptoms. This case illustrates painful impingement of soft tissue on the triquetrum. Possibly, the source of tissue impingement may include different extra-articular or torn intra-articular structures. Soft tissue impingement on the triquetrum may be a cause of ulnar-sided wrist pain following failed TFCC repair. PMID:23904982

Wollstein, Ronit; Unadkat, Jignesh; Grand, Aaron

2012-01-01

2

[TFCC-lesion. MR arthrography vs. arthroscopy of the wrist].  

PubMed

In a blinded study from January to July 2000, 125 patients suffering from specific complaints of the wrist were examined with direct MR arthrography prospectively. Within 24 hours an arthroscopy of the wrist was performed. With the MR arthrography in 70 patients or 56% of all patients injury of the TFCC was diagnosed. In 65 patients this could be verified arthroscopically. In the remaining 55 patients no TFCC lesion was diagnosed with the MR arthrography. However lesions were found via arthroscopy in three cases,were MRI findings expected an intact TFCC. In the remaining 52 cases the MRT could exclude a lesion of the TFCC correctly. An agreement of the MRT and arthroscopic results could be determined in 93.6% of the cases (correlation). The diagnosis of a TFCC lesion by means of MRI was correct in 94% of the cases (sensitivity), the exclusion of such lesion in 89% (specificity). Positive or negative predictive values of 91% or 93% were achieved. Since neither a specificity nor a sensitivity of 100% can be reached at the moment, the MR arthrography cannot replace the arthroscopy. However it could be a potent additional tool for wrist diagnosis if intraarticular contrast is used. It can facilitate the diagnostics and the indication for surgery at the ulnocarpal wrist and help to reduce arthroscopic interventions that are only for diagnostic purposes and without any therapeutic consequences. With improvement of the technique of magnet resonance tomography we can expect further increase of accuracy and the clinical use of the MR arthrography in the diagnostic workup at the ulnocarpal wrist. PMID:12658336

Meier, R; Schmitt, R; Christopoulos, G; Krimmer, H

2003-03-01

3

Arthroscopic Repairs of Triangular Fibrocartilage Complex Tears  

Microsoft Academic Search

Technical advancements in arthroscopic wrist procedures have improved our knowledge of normal and abnormal intraarticular wrist function. Triangular fibrocartilage complex (TFCC) tears from trauma injuries are a common source of ulnar-sided wrist pain. Fortunately, the TFCC is a structure that can be evaluated and treated arthroscopically with results that are comparable to open surgical procedures. Successful arthroscopic repairs of TFCC

Patricia Baehser-Griffith; John M. Bednar; A. Lee Osterman; Randall Culp

1997-01-01

4

A Newer Technique of Distal Ulna Reconstruction Using Proximal Fibula and TFCC Reconstruction Using Palmaris Longus Tendon following Wide Resection of Giant Cell Tumour of Distal Ulna  

PubMed Central

Giant cell tumour of the bone (GCT) is a rare locally aggressive primary bone tumour with an incidence of 3% to 5% of all primary bone tumours. The most common location for this tumour is the long bone metaepiphysis especially of the distal femur, proximal tibia, distal radius, and the proximal humerus. Involvement of distal ulna is rare accounting for 0.45% to 3.2%. Considering local aggressive nature and high recurrence, wide resection is the treatment recommended. Instability of ulnar stump and ulnar translation of the carpals are known complications following resection of distal ulna. To overcome these problems, we attempted a newer technique of distal ulna reconstruction using proximal fibula and TFCC reconstruction using palmaris longus tendon following wide resection of giant cell tumour of distal ulna in a 44-year-old male. This technique of distal radioulnar joint reconstruction has excellent functional results with no evidence of recurrence after one-year followup. PMID:24455371

Mariappan, Elango; Mohanen, Pragash; Moses, Justin

2013-01-01

5

Various patterns of traumatic triangular fibrocartilage complex tear.  

PubMed

We demonstrate various patterns of traumatic triangular fibrocartilage complex (TFCC) tears including some atypical that cannot be categorized under Palmer's classification. TFCC traumatic tears in 173 wrists were examined arthroscopically or macroscopically and divided into disk tears (subdivided into four types: slit tear, flap tear, horizontal tear and tear within the distal radioulnar joint) and peripheral tears (subdivided into six types: ulnocarpal ligament tear, dorsal tear, radial tear, ulnar styloid tear, foveal tear and distal radioulnar ligament tear). Combinations of these types were found in 32 wrists. Wrist arthroscopy revealed various traumatic TFCC tears that do not come under Palmer's classification; therefore establishment of a new classification for traumatic TFCC tears seems to be warranted. PMID:22745082

Abe, Y; Tominaga, Y; Yoshida, K

2012-01-01

6

COMPLEX TRAUMA, COMPLEX REACTIONS: ASSESSMENT AND TREATMENT  

Microsoft Academic Search

Complex trauma occurs repeatedly and escalates over its duration. In families, it is exemplified by domestic violence and child abuse and in other situations by war, prisoner of war or refugee status, and human trafficking. Complex trauma also refers to situations such as acute\\/chronic illness that requires intensive medical intervention or a single traumatic event that is calamitous. Complex trauma

Christine A. Courtois

2004-01-01

7

Complex Trauma, Complex Reactions: Assessment and Treatment  

Microsoft Academic Search

Complex trauma occurs repeatedly and escalates over its duration. In families, it is exemplified by domestic violence and child abuse and in other situations by war, prisoner of war or refugee status, and human trafficking. Complex trauma also refers to situations such as acute\\/chronic illness that requires intensive medical intervention or a single traumatic event that is calamitous. Complex trauma

Christine A. Courtois

2008-01-01

8

Complexity in the Treatment of Naming Deficits  

PubMed Central

Purpose This paper discusses a novel approach for treatment of lexical retrieval deficits in aphasia in which treatment begins with complex, rather than simple, lexical stimuli. This treatment considers the semantic complexity of items within semantic categories, with a focus on their featural detail. Methods and Results Previous work on training items within animate categories (Kiran & Thompson, 2003a) and preliminary work aimed at items within inanimate categories are discussed in this paper. Both these studies indicate that training atypical category items that entail features inherent in the category prototype as well as distinctive features that are not characteristic of the category prototype results in generalization to untrained typical examples which entail only features consistent with the category prototype. Conversely, training typical examples does not result in generalization to untrained atypical examples. In this paper, it is argued that atypical items are more complex than typical items within a category and a theoretical framework for this dimension of semantic complexity is discussed. Then, evidence from treatment studies that support this complexity hierarchy is presented. Potential patient- and stimulus- specific factors that may influence the success of this treatment approach are also discussed. Conclusions The applications of semantic complexity to treatment of additional semantic categories and functional applications of this approach are proposed. PMID:17329672

Kiran, Swathi

2009-01-01

9

Ulnar-sided wrist pain. II. Clinical imaging and treatment  

PubMed Central

Pain at the ulnar aspect of the wrist is a diagnostic challenge for hand surgeons and radiologists due to the small and complex anatomical structures involved. In this article, imaging modalities including radiography, arthrography, ultrasound (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography are compared with regard to differential diagnosis. Clinical imaging findings are reviewed for a more comprehensive understanding of this disorder. Treatments for the common diseases that cause the ulnar-sided wrist pain including extensor carpi ulnaris (ECU) tendonitis, flexor carpi ulnaris (FCU) tendonitis, pisotriquetral arthritis, triangular fibrocartilage complex (TFCC) lesions, ulnar impaction, lunotriquetral (LT) instability, and distal radioulnar joint (DRUJ) instability are reviewed. PMID:20012039

Watanabe, Atsuya; Souza, Felipe; Vezeridis, Peter S.; Blazar, Philip

2009-01-01

10

[Complex treatment of patients with acute paraproctitis].  

PubMed

Results of the treatment of 3253 patients with acute paraproctitis are analysed. The treatment must be complex, with a radical operative intervention as a decisive measure directed to a radical dissection of the abscess and liquidation of the internal opening of the abscess in the rectum. Positive results were obtained in 88,3% of the patients. PMID:3890336

Sakhautdinov, V G; Shenberger, I L; Timerbulatov, V M; Smakaev, R U; Ishimov, M S

1985-02-01

11

Advantages of open repair of a foveal tear of the triangular fibrocartilage complex via a palmar surgical approach.  

PubMed

Foveal tears of the triangular fibrocartilage complex (TFCC) can be repaired via a palmar surgical approach. Unlike the dorsal approach, in this method the floor of the extensor carpi ulnaris tendon subsheath and the dorsal superficial limb of the radioulnar ligament do not hinder the view of the fovea. Patients with a fresh or chronic TFCC foveal tear and a positive ulnar fovea sign with its dorsal styloid insertion remaining intact are candidates for this procedure. During operation, the shoulder is positioned at 90 degrees of abduction, and the elbow is flexed at 90 degrees on an arm board. A 4 cm curved skin incision along the flexor carpi ulnaris tendon is made on the anterior aspect of the ulnar fovea. The ulnar fovea is exposed through a transverse capsulotomy of the distal radioulnar joint. The ulnocarpal joint distal to the TFCC is also exposed between the extensor carpi ulnaris tendon subsheath and the ulnotriquetrum ligament. After curettage of the scar tissues at the fovea, the lifted TFCC is sutured onto the fovea using a suture anchor technique. PMID:19956042

Moritomo, Hisao

2009-12-01

12

[The use of cryosupernatant plasma in complex treatment of pancreonecrosis].  

PubMed

Comparative study of results of complex treatment of pancreonecrosis in 60 patients using cryosupernatant plasma (CSNP) and fresh frozen plasma was carried out. Better positive dynamics in some laboratory indices, less lethality and better outcomes were marked with use of CSNP. It can be used instead of fresh frozen plasma in complex treatment of pancreonecrosis and concomitant DIC syndrome. PMID:18833146

Tse?makh, E A; Bombizo, V A; Buldakov, P N; Siniavin, A V; Osipov, E S; Meliksetian, A D; Orekhov, D A; Smirnova, O I

2008-01-01

13

[Artemisia absinthium L. in complex treatment of inflammatory periodontal disease].  

PubMed

The effectiveness of Artemisia absinthium L. in complex treatment of inflammatory periodontal disease was assessed in the study by ELIZA evaluation of PGE2 in mixed saliva. Microcirculation in periodontal tissues was also assessed by means of laser Doppler flowmetry. It was found out that complex treatment involving Artemisia absinthium L. improves microcirculation in periodontal tissues and reduces inflammation. PMID:23011328

Krechina, E K; Belorukov, V V

2012-01-01

14

12. NORTHEAST VIEW OF THE WASTE WATER TREATMENT COMPLEX FOR ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. NORTHEAST VIEW OF THE WASTE WATER TREATMENT COMPLEX FOR THE PRIMARY AND 22 BAR MILLS. - U.S. Steel Duquesne Works, Auxiliary Buildings & Shops, Along Monongahela River, Duquesne, Allegheny County, PA

15

[Glutoxim in the complex treatment of tuberculosis].  

PubMed

Results of Glutoxim investigation are presented. Glutoxim is the the drug of the new class--thiopoietins. It is considered to be immunorehabilitator as it modulates intracellular process of thiols metabolism, initiates cytokins system, activates phagocytosis etc. Results of the glutoxim administration at the 42 patients with tuberculosis using traditional treatment regimes are presented. Results of the randomized study at the patients with severe disseminated drug-sensitive and drug-resistant pulmonary tuberculosis demonstrated high efficacy of the glutoxim and its good tolerability. Glutoxim administration allowed to shorten the period of tuberculosis intoxication signs disappearance, to shorten the period of sputum negativation and shortened the period of pulmonary inflammation reverse process. Glutoxim application was specially favorable at the patients with severe tuberculosis complicated by viral or medicamental hepatitis. PMID:12087719

Sokolova, G B; Sinitsyn, M V; Kozhemiakin, L A; Perel'man, M I

2002-01-01

16

[Cortexin in the complex treatment of post stroke epilepsy].  

PubMed

Forty-six patients with post stroke epilepsy were examined. The basic treatment included depakine-chrono in the mean dosage of 750 mg per day, along with vascular drugs, Cortexin was used as an add-on therapy in 29 patients intramuscular in the dosage of 10 mg during 15 days. Other 17 patients received only basic therapy. The addition of cortexin to the complex treatment significantly enhanced clinical effects reflected by positive changes on EEG. PMID:20873481

Gafurov, B G; Gafurov, Sh B

2010-01-01

17

The challenge of treatment in bipolar depression: evidence from clinical guidelines, treatment recommendations and complex treatment situations.  

PubMed

Bipolar depression and its clinical presentation is a frequent but complex psychiatric disease. Despite the high prevalence and the clinical and economic relevance of bipolar depression, few treatments are proven to be highly and consistently effective. In practice, the treatment of bipolar depression typically includes complex treatment decision-making. The best evidence for a pharmacological treatment exists for quetiapine. Alternatives with limitations are lamotrigine (also in the combination with lithium), carbamazepine and olanzapine. The effectiveness and recommendation of antidepressants in the treatment of bipolar depression remains controversial. Initially, depressive episodes should been treated with one of the named substances with antidepressant properties. In non-responders, a combination of lithium and lamotrigine, or antidepressants in combination with either lithium, an antiepileptic drug or atypical antipsychotics, may be necessary. If a depressive episode occurs under ongoing mood-stabilizing treatment, combination treatments of different substances, even with antidepressants, can be necessary. In the case of treatment-resistant depressive episodes, complex treatment strategies (combination therapies, MAO inhibitors) should be considered. This review describes the treatment recommendations of different guidelines for bipolar depression and emphasizes their differences. Furthermore, alternative pharmacological treatment strategies and complex treatment situations are discussed. PMID:24549861

Köhler, S; Gaus, S; Bschor, T

2014-03-01

18

Treatment plan complexity metrics for predicting IMRT pre-treatment quality assurance results.  

PubMed

The planning of IMRT treatments requires a compromise between dose conformity (complexity) and deliverability. This study investigates established and novel treatment complexity metrics for 122 IMRT beams from prostate treatment plans. The Treatment and Dose Assessor software was used to extract the necessary data from exported treatment plan files and calculate the metrics. For most of the metrics, there was strong overlap between the calculated values for plans that passed and failed their quality assurance (QA) tests. However, statistically significant variation between plans that passed and failed QA measurements was found for the established modulation index and for a novel metric describing the proportion of small apertures in each beam. The 'small aperture score' provided threshold values which successfully distinguished deliverable treatment plans from plans that did not pass QA, with a low false negative rate. PMID:24810792

Crowe, S B; Kairn, T; Kenny, J; Knight, R T; Hill, B; Langton, C M; Trapp, J V

2014-09-01

19

Treatment for ADHD: Is More Complex Treatment Cost-Effective for More Complex Cases?  

PubMed Central

Objective To determine the cost-effectiveness of three alternative high-quality treatments for attention deficit hyperactivity disorder (ADHD) relative to community care (CC) and to determine whether cost-effectiveness varies with the presence of comorbid disorders. Data Sources/Collection The study included 579 children ages 7–9.9 with diagnosed ADHD at six sites. Data for the study were distilled from administrative data and from interviews with parents, including estimates of the child's functional impairment. These analyses focus on changes in functional impairment over 14 months. Study Design The study involved a large clinical trial that randomized participants to one of four arms: routine CC, intensive medication management (MedMgt), multicomponent behavioral treatment, and a combination of behavioral treatment and medication. Principal Findings We assessed the cost-effectiveness of the alternatives using costs measured from a payer perspective. The preferred cost-effective treatment varies as a function of the child's comorbidity and of the policy maker's willingness to pay. For pure (no comorbidity) ADHD, high-quality MedMgt appears likely to be cost-effective at all levels of willingness to pay. In contrast, for some comorbid conditions, willingness to pay is critical: the policy maker with low willingness to pay likely will judge MedMgt most cost-effective. On the other hand, a policy maker willing to pay more now in expectation of future costs savings (involving, for example, juvenile justice), will recognize that the most cost-effective choice for comorbid conditions likely involves behavior therapy, with or without medication. Conclusions Analyses of costs and effectiveness of treatment for ADHD must consider the role of comorbidities. PMID:17355587

Foster, E Michael; Jensen, Peter S; Schlander, Michael; Pelham, William E; Hechtman, Lily; Arnold, L Eugene; Swanson, James M; Wigal, Timothy

2007-01-01

20

Investigating the reproducibility of a complex multifocal radiosurgery treatment  

NASA Astrophysics Data System (ADS)

Stereotactic radiosurgery has become a widely used technique to treat solid tumors and secondary metastases of the brain. Multiple targets can be simultaneously treated with a single isocenter in order to reduce the set-up time to improve patient comfort and workflow. In this study, a 5-arc multifocal RapidArc treatment was delivered to multiple PRESAGE® dosimeters in order to explore the repeatability of the treatment. The three delivery measurements agreed well with each other, with less than 3% standard deviation of dose in the target. The deliveries also agreed well with the treatment plan, with gamma passing rates greater than 90% (5% dose-difference, and 2 mm distance-to-agreement criteria). The optical-CT PRESAGE® system provided a reproducible measurement for treatment verification, provided measurements were made immediately following treatment.

Niebanck, M.; Juang, T.; Newton, J.; Adamovics, J.; Wang, Z.; Oldham, M.

2013-06-01

21

AUTOMATED COMPLEX FOR EB TREATMENT OF CABLE AND WIRE INSULATION  

Microsoft Academic Search

The improved electron accelerator for cable insulation treatment equipped with 4-side irradiation system was developed in Budker -Institute of Nuclear Physics on the basis of ELV series accelerator and was put into operation in \\

N. K. Kuksanov; R. A Salimov; P. I Nemytov; A. V. Lavruchin; I. Golubenko; S. N. Fadeev

22

Modern Palliative Radiation Treatment: Do Complexity and Workload Contribute to Medical Errors?  

SciTech Connect

Purpose: To examine whether treatment workload and complexity associated with palliative radiation therapy contribute to medical errors. Methods and Materials: In the setting of a large academic health sciences center, patient scheduling and record and verification systems were used to identify patients starting radiation therapy. All records of radiation treatment courses delivered during a 3-month period were retrieved and divided into radical and palliative intent. 'Same day consultation, planning and treatment' was used as a proxy for workload and 'previous treatment' and 'multiple sites' as surrogates for complexity. In addition, all planning and treatment discrepancies (errors and 'near-misses') recorded during the same time frame were reviewed and analyzed. Results: There were 365 new patients treated with 485 courses of palliative radiation therapy. Of those patients, 128 (35%) were same-day consultation, simulation, and treatment patients; 166 (45%) patients had previous treatment; and 94 (26%) patients had treatment to multiple sites. Four near-misses and 4 errors occurred during the audit period, giving an error per course rate of 0.82%. In comparison, there were 10 near-misses and 5 errors associated with 1100 courses of radical treatment during the audit period. This translated into an error rate of 0.45% per course. An association was found between workload and complexity and increased palliative therapy error rates. Conclusions: Increased complexity and workload may have an impact on palliative radiation treatment discrepancies. This information may help guide the necessary recommendations for process improvement for patients who require palliative radiation therapy.

D'Souza, Neil, E-mail: neil.dsouza@sunnybrook.ca [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada) [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Holden, Lori [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada) [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Robson, Sheila [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada)] [Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Mah, Kathy; Di Prospero, Lisa; Wong, C. Shun; Chow, Edward; Spayne, Jacqueline [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada) [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada)

2012-09-01

23

Comparison of Chemical Composition of Complex Disinfection Byproduct (DBP) Mixtures Produced by Different Treatment Methods - slides  

EPA Science Inventory

Analyses of the chemical composition of complex DBP mixtures, produced by different drinking water treatment processes, are essential to generate toxicity data required for assessing their risks to humans. For mixture risk assessments, whole mixture toxicology studies generally a...

24

Comparison of Chemical Composition of Complex Disinfection Byproduct (DBP) Mixtures Produced by Different Treatment Methods  

EPA Science Inventory

Analyses of the chemical composition of complex DBP mixtures, produced by different drinking water treatment processes, are essential to generate toxicity data required for assessing their risks to humans. For mixture risk assessments, whole mixture toxicology studies generally a...

25

Adherence to antiretroviral treatment in patients with HIV in the UK: a study of complexity  

Microsoft Academic Search

Adherence to HIV treatment regimes is a core element to viral suppression. Yet measurement of adherence is complex. Although adherence levels are good predictors of outcome, they do not always provide full explanations of observed variations in responses. This study was set up to examine the complexity of adherence measurement and to examine rates of adherence in the presence of

Lorraine Sherr; Fiona Lampe; Sally Norwood; Heather Leake Date; Richard Harding; Margaret Johnson; Simon Edwards; Martin Fisher; Gilly Arthur; Sarah Zetler; Jane Anderson

2008-01-01

26

Effective Treatment of Complex Post Traumatic Stress Disorder and Early Attachment Trauma  

Microsoft Academic Search

Research on and disagreements regarding the appropriate treatments for various types of traumas have existed throughout the history of psychotherapy. While approaches have differed over the years, current research suggests that prolonged exposure therapy, long considered the most efficacious treatment for single incident trauma, may be at best ineffectual for treating the condition known as Complex Post Traumatic Stress Disorder,

Emily R Murphrey

2011-01-01

27

An efficient immersed boundary treatment for complex moving object  

NASA Astrophysics Data System (ADS)

An efficient immersed boundary treatment for simulation of flexible moving body immersed in fluid is presented. The level set signed distance function is used to indicate body surface. A simple mapping strategy is proposed to avoid costly signed distance re-initialization computations. The strategy is efficient for both rigid and deformable structures, and can be extended to 3-D case easily. With the use of signed distance function, reconstruction of flow variables on a body surface can be easily implemented through linear, bilinear or quadratic interpolation. In order to suppress the pressure oscillations caused by the role conversion of forcing points and fluid points, a modified interpolation scheme is presented by introducing a dynamic weight term to the fluid point. Together with local grid refinement and using larger time step, the pressure oscillations can be effectively diminished by the modified interpolation scheme. The proposed method is validated by 2-D numerical simulations on a uniform flow past a fixed cylinder, in-line and transversely oscillating cylinders, a flapping wing, a 3-D simulation on a uniform flow past a rectangle plane with an initial attack angle and a moving anguilliform swimmer. Present numerical results are compared with other CFD solutions as well as experimental results.

Liu, Cheng; Hu, Changhong

2014-10-01

28

Retroperitoneal laparoscopic technique in treatment of complex renal stones: 75 cases  

PubMed Central

Background In most hospitals, several options for the management of renal stones are available: shockwave lithotripsy, endourologic treatment, or surgery. Choice of treatment is based on the anatomic characteristics of the patient, and the location and size of the stones. In this study we assessed a retroperitoneal laparoscopic technique for treatment of complex renal stones. Methods Seventy-five patients, including 53 men and 22 women with a mean age of 47.8 years (range 18–74 y), underwent retroperitoneal laparoscopy for the treatment of complex renal stones between July 2006 and November 2012 in our hospital. Results The retroperitoneal laparoscopic procedures for treatment of complex renal stones were completely successful in 73 cases, while 2 cases converted to open surgery. The operative time was 85–190 min with a mean of 96 min. The estimated blood lost was 20–400 mL with a mean of 80 mL. After the operation 7 patients experienced urinary leakage. Ultrasonography, x-ray of the kidney, ureter and bladder, and intravenous urography were reviewed at post-procedural follow-up at 6–82 months. No hydronephrosis aggravation was found, and there was no calculus recurrence. Conclusion The merits of retroperitoneal laparoscopy for the treatment of complex renal stones include sparing the nephron, less bleeding, short hospitalization, quick postoperative recovery, and controllable procedure after training Success depends on the experience of surgeons and judicious selection of cases. PMID:24491207

2014-01-01

29

Treating complex trauma among veterans: three stage-based treatment models.  

PubMed

This article addresses the issue of complex trauma in veterans and treatments for symptom presentations resulting from complex trauma exposure. While various definitions have been proposed for complex trauma, the clinical issues related to it are relevant for veterans as they are at risk for cumulative trauma exposures such as multiple combat deployments and military sexual trauma. Several treatments were either developed to address and/or implemented with complex trauma. This article discusses three of these treatments that share a stage-based approach, focusing on the present (e.g., skills training and psychoeducation), which can then be followed, if needed, with a past-focused (e.g., exposure-based) treatment: Dialectical Behavior Therapy (Linehan, 1993), Seeking Safety (Najavits, 2002), Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (Cloitre, Cohen, & Koenen, 2006). This article also discusses what is currently being done to address symptom presentations resulting from complex trauma exposure and challenges and possible solutions to implementing this care. PMID:23529776

Landes, Sara J; Garovoy, Natara D; Burkman, Kristine M

2013-05-01

30

[Soy-based food in a complex treatment of patients with tuberculosis].  

PubMed

Results of clinical and laboratoty studies on efficiency and safety of upplied soya-based food during intensive antimicobacterial treatment of patients with tuberculosis are presented in the article. Obtained results showed the necessity of introduction soya-based food in a complex treatment of this infection as it enhances processes of detoxication, positevely influences on functional and structural state of the liver, reduces cytolysis, cholestasis symptomes, mesenchymal and inflamation reactions thus increases the tolerance of antimicobacterial agents. PMID:17427429

Mel'nyk, V P; Anisimova, Iu M; Borovs'ky?, V R; Stadnyk, L V; Svitlychna, T H

2006-12-01

31

Platinum(II)-Gadolinium(III) Complexes as Potential Single-Molecular Theranostic Agents for Cancer Treatment.  

PubMed

Theranostic agents are emerging multifunctional molecules capable of simultaneous therapy and diagnosis of diseases. We found that platinum(II)-gadolinium(III) complexes with the formula [{Pt(NH3 )2 Cl}2 GdL](NO3 )2 possess such properties. The Gd center is stable in solution and the cytoplasm, whereas the Pt centers undergo ligand substitution in cancer cells. The Pt units interact with DNA and significantly promote the cellular uptake of Gd complexes. The cytotoxicity of the Pt-Gd complexes is comparable to that of cisplatin at high concentrations (?0.1?mM), and their proton relaxivity is higher than that of the commercial magnetic resonance imaging (MRI) contrast agent Gd-DTPA. T1 -weighted MRI on B6 mice demonstrated that these complexes can reveal the accumulation of platinum drugs in vivo. Their cytotoxicity and imaging capabilities make the Pt-Gd complexes promising theranostic agents for cancer treatment. PMID:25255766

Zhu, Zhenzhu; Wang, Xiaoyong; Li, Tuanjie; Aime, Silvio; Sadler, Peter J; Guo, Zijian

2014-11-24

32

Intravenous laser irradiation of blood in the complex treatment for acute and progressive tuberculosis in adolescents  

NASA Astrophysics Data System (ADS)

Twenty-three out of forty-four adolescents affected by acute and progressive tuberculosis were administered a complex treatment based on the intravenous laser irradiation of blood. This treatment started 2 to 4 weeks after the beginning of chemotherapy. The efficiency of the treatment was assessed by clinical and laboratory criteria obtained after 1.5 to 2 months. It was found that the application of (lambda) equals 0.63 micrometers laser irradiation increased the therapeutic effect and stimulated the healing of the disease. Moreover, it enabled the achievement of a quiet course of tuberculosis with less pronounced residual changes in the lungs.

Rusakova, L. I.; Dobkin, V. G.; Ovsyankina, E. S.; Firsova, V. A.; Bondarev, G. B.; Sidorov, V. A.

2001-04-01

33

Effects of amylose chain length and heat treatment on amylose-glycerol monocaprate complex formation.  

PubMed

Aqueous mixtures of amylose with different chain lengths (DP 23-849), which had been enzymatically synthesized or isolated from potato and maize starches, and glycerol monocaprate (GMC, 5:1 weight ratio) were analyzed by using a differential scanning calorimeter (DSC). The mixtures were thermally treated (first DSC scan: 20-140 °C, 5 °C/min and prolonged heat treatment: 100 °C for 24 h) and its effect on the amylose-GMC complex formation was analyzed by DSC and X-ray diffractometer. The amylose, especially short ones, readily associated in the dispersion forming the amylose-amylose crystals but the presence of GMC inhibited the crystal formation. The longer amylose had the greater possibility for the complex formation with GMC, and the prolonged heat treatment facilitated the amylose-GMC complex formation. Both type I and type II complexes were formed during quenching after the initial DSC heating. However, only the type II complexes were formed after the prolonged heat treatment with improved crystallinity and thermostability. PMID:23618264

Zhou, Xing; Wang, Ren; Zhang, Yuxian; Yoo, Sang-Ho; Lim, Seung-Taik

2013-06-01

34

Inulin–iron complexes: A potential treatment of iron deficiency anaemia  

Microsoft Academic Search

The aim of this work was that to synthesize macromolecular derivatives based on inulin able to complex iron and useful in the treatment of iron deficiency anaemia. Carboxylated or thiolated\\/carboxylated inulin derivatives were obtained by single or double step reactions, respectively. The first one was obtained by reaction of inulin (INU) with succinic anhydride (SA) alone obtaining INU–SA derivative; the

Giovanna Pitarresi; Giuseppe Tripodo; Gennara Cavallaro; Fabio Salvatore Palumbo; Gaetano Giammona

2008-01-01

35

Incontinence after Surgery for Benign Prostatic Hypertrophy: The Case for Complex Approach and Treatment  

Microsoft Academic Search

Objective: Whether incontinence after surgery for benign prostatic hypertrophy (BPH) requires simple workup and treatment or being a more complex condition and multifactorial in etiology requiring combined surgical techniques should be investigated in more detail. Methods: We retrospectively reviewed the records of 56 patients referred to us for post-prostatectomy incontinence after surgery for BPH. All patients were subjected to urodynamics.

Ch. Theodorou; G. Moutzouris; D. Floratos; D. Plastiras; Ch. Katsifotis; N. Mertziotis

1998-01-01

36

Complex Psychiatric Comorbidity of Treatment-Seeking Youth with Autism Spectrum Disorder and Anxiety Symptoms  

ERIC Educational Resources Information Center

This descriptive study examines the complexity of psychiatric comorbidity in treatment-seeking youth with ASD and anxiety symptoms. Forty-two parents of youth with ASD and anxiety (ages 8-14) completed a structured diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version). Youth…

Hepburn, Susan L.; Stern, Jessica A.; Blakeley-Smith, Audrey; Kimel, Lila K.; Reaven, Judith A.

2014-01-01

37

Optimisation of complex water supply systems with water quality, hydraulic and treatment plant aspects  

Microsoft Academic Search

A model for optimal operation of a complex water supply system for drinking water and with water quality, hydraulic and desalination treatment plants developed by Cohen and others has been applied to a realistic regional network, in which water quality is defined by salinity, magnesium and sulphur. The model considers the hydraulics of the network, including pump stations, boosters and

Dani Cohen; Uri Shamir; Gideon Sinai

2009-01-01

38

Treatment of Early Complex Regional Pain Syndrome Type 1 by A Combination of Mannitol and Dexamethasone  

Microsoft Academic Search

A total of 75 patients, 68 women (91%) and seven men (9%), with a mean age of 58 (range 38–82) years with early Complex Regional Pain Syndrome Type 1 (CRPS Type 1), present for less than 4 months, were given in-patient treatment with 10% mannitol 2 ? 250 ml per day and 8 mg dexamethasone per day for 1 week.

A. ZYLUK; P. PUCHALSKI

2008-01-01

39

Complex treatment of trophic affections with vascular patients using monochromatic red light and hyperbaric oxygenation  

NASA Astrophysics Data System (ADS)

Monochromatic red light irradiation therapy of trophic skin affections with vascular patients permits to receive positive results with small wounds. A combination of monochromatic red light and hyperbaric oxygenation is most perspective when conducting a complex therapy of trophic wounds not more than 40 mm2 and allows to diminish time of treatment almost two times.

Babkina, Zinaida M.; Vasilyev, Mikhail V.; Zakharov, Vyacheslav P.; Nikolayev, Viktor V.; Babkin, Vasily I.; Samoday, Valery G.; Zon, Boris A.; Pakhomov, Gennady V.; Naskidashvili, Vasily I.; Kumin, Anatoly A.

1996-11-01

40

[Application of nootropic agents in complex treatment of patients with concussion of the brain].  

PubMed

65 patients with a mild craniocereberal trauma have been observed. Medical examination included among general clinical methods the following methods: KT (MRT) of the brain, oculist examination including the observation of eye fundus. For objectification of a patient' complaints the authors used orientation and Galvestona's amnesia tests, feeling scale (psychological test), the table to determine the level of memory. Tests have been carried out on the first, tenth and thirty day of the treatment. Patients of the first group received in a complex treatment -pramistar, patients of the second group - piracetam. Patients of both groups noted considerable improvement during a complex treatment (disappearance of headache, dizziness and nausea) and at the same time patients receiving pramistar had better restoration of orientation and feeling. Pramistar was also more effective in patients with amnesia. PMID:18418926

Tkachev, A V

2007-01-01

41

The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy.  

PubMed

Three adhesion complexes span the sarcolemma and facilitate critical connections between the extracellular matrix and the actin cytoskeleton: the dystrophin- and utrophin-glycoprotein complexes and ?7?1 integrin. Loss of individual protein components results in a loss of the entire protein complex and muscular dystrophy. Muscular dystrophy is a progressive, lethal wasting disease characterized by repetitive cycles of myofiber degeneration and regeneration. Protein-replacement therapy offers a promising approach for the treatment of muscular dystrophy. Recently, we demonstrated that sarcospan facilitates protein-protein interactions amongst the adhesion complexes and is an important potential therapeutic target. Here, we review current protein-replacement strategies, discuss the potential benefits of sarcospan expression, and identify important experiments that must be addressed for sarcospan to move to the clinic. PMID:23601082

Marshall, Jamie L; Kwok, Yukwah; McMorran, Brian J; Baum, Linda G; Crosbie-Watson, Rachelle H

2013-09-01

42

Orthodontic Treatment Need and Complexity among Nigerian Adolescents in Rivers State, Nigeria.  

PubMed

Introduction. The assessment of orthodontic treatment need and complexity are necessary for informed planning of orthodontic services. The aim of this cross-sectional study was to assess these parameters using the Index of Complexity, Outcome, and Need (ICON) in a Nigerian adolescent population in a region where orthodontic services are just being established. Methods. Six hundred and twelve randomly selected Nigerian adolescents aged 12 to 18 years were examined using the ICON in their school compounds. Descriptive statistics were employed in the data analysis. Results. Out of a total of 38.1% of the population found to need orthodontic treatment, there were more males and older adolescents. The overall mean ICON score for the population was 39.7 ± 25.3 SD with males having statistically higher mean ICON score. The grades of complexity of the population were 21.6% for very difficult and difficult, 7.5% moderate, and 70.9% mild/easy. Conclusions. Although just over a third of the adolescents were found to have a need for treatment, about a quarter of them were found to have difficult and very difficult complexity grades indicating a need for specialist care. The authors recommend the training of more specialist orthodontists in this region. PMID:22121361

Aikins, Elfleda Angelina; Dacosta, Oluranti Olatokunbo; Onyeaso, Chukwudi Ochi; Isiekwe, Michael Chukwudi

2011-01-01

43

[An ontogenic conception of complex multilevel treatment of psychosomatic disorders in children].  

PubMed

The author suggests a conception that considers the etiopathogenesis of psychogenic psychosomatic disorders as a chain of interacting factors. The main patterns of it are stressful life events, personality, psychotype, somatotype, systemic/organic deficit. Mechanisms of stable pathological state join this chain into a "vicious circle" of psychosomatosis. Based on the ontogenetic approach, the author suggests a 5-level system of the complex (psychosomatic) treatment of these disorders. The system integrates pharmacological treatment, neuropsychological correction, syndromal psychological correction of alexithymia and emotional sphere, modification of behavior and personality-oriented psychotherapy. PMID:23739511

Shevchenko, Iu S

2013-01-01

44

[A new approach to postexposure treatment of rabies by complex of immuno- and chemotherapy in belarus].  

PubMed

A method for preventive treatment of rabies with a complex of immuno- and chemotherapeutics was developed. Rifampicin was used a an etiotropic drug. In the experiments on laboratory animals infected with fixed and street strains of rabies virus it was shown to prolong the incubation period and to increase the survival rate. The protective mechanisms of rifampicin against rabies should be associated with inhibition of RNA transcription, as well as immunomodulating function of macrophages, dendritic cells, B- and T-cells. Since 1992, after the approval of the Ministry of Health of Belarus rifampicin is used in complex with antirabic vaccine for postexposure treatment of rabies in people after severe bites by infected animals (wolves, foxes, dogs). For an 18-year period (1992-2009) of integrated application of chemo- and immunotherapy in Belarus there was not registered any case of hydrophobia in people even after the heaviest wolf bites, incompatible with life (penetrating injuries of the skull, scalping, multiple bites). PMID:24734427

Mishaeva, N P; Votiakov, V I; Titov, L P; Naralenkov, V A; Nekha?, M R; Sinkevich, V V; Kurlukov, A I; Gorbunov, V A

2013-01-01

45

Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome  

PubMed Central

Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median = 3 weeks) but intensive physical and psychological treatment program, and compared them to matched healthy controls. Differences in intrinsic brain networks were observed in P-CRPS compared to controls before treatment (disease state) with the most prominent differences in the fronto-parietal, salience, default mode, central executive, and sensorimotor networks. Following treatment, behavioral measures demonstrated a reduction of symptoms and improvement of physical state (pain levels and motor functioning). Correlation of network connectivities with spontaneous pain measures pre- and post-treatment indicated concomitant reductions in connectivity in salience, central executive, default mode and sensorimotor networks (treatment effects). These results suggest a rapid alteration in global brain networks with treatment and provide a venue to assess brain changes in CRPS pre- and post-treatment, and to evaluate therapeutic effects. PMID:25379449

Becerra, Lino; Sava, Simona; Simons, Laura E.; Drosos, Athena M.; Sethna, Navil; Berde, Charles; Lebel, Alyssa A.; Borsook, David

2014-01-01

46

Factors that lessen the burden of treatment in complex patients with chronic conditions: a qualitative study  

PubMed Central

Purpose Patients with multiple chronic conditions (multimorbidity) often require ongoing treatment and complex self-care. This workload and its impact on patient functioning and well-being are, together, known as treatment burden. This study reports on factors that patients with multimorbidity draw on to lessen perceptions of treatment burden. Patients and methods Interviews (n=50) and focus groups (n=4 groups, five to eight participants per group) were conducted with patients receiving care in a large academic medical center or an urban safety-net hospital. Interview data were analyzed using qualitative framework analysis methods, and themes and subthemes were used to identify factors that mitigate burden. Focus groups were held to confirm these findings and clarify any new issues. This study was part of a larger program to develop a patient-reported measure of treatment burden. Results Five major themes emerged from the interview data. These included: 1) problem-focused strategies, like routinizing self-care, enlisting support of others, planning for the future, and using technology; 2) emotion-focused coping strategies, like maintaining a positive attitude, focusing on other life priorities, and spirituality/faith; 3) questioning the notion of treatment burden as a function of adapting to self-care and comparing oneself to others; 4) social support (informational, tangible, and emotional assistance); and 5) positive aspects of health care, like coordination of care and beneficial relationships with providers. Additional subthemes arising from focus groups included preserving autonomy/independence and being proactive with providers. Conclusion Patients attempt to lessen the experience of treatment burden using a variety of personal, social, and health care resources. Assessing these factors in tandem with patient perceptions of treatment burden can provide a more complete picture of how patients fit complex self-care into their daily lives. PMID:24672228

Ridgeway, Jennifer L; Egginton, Jason S; Tiedje, Kristina; Linzer, Mark; Boehm, Deborah; Poplau, Sara; de Oliveira, Djenane Ramalho; Odell, Laura; Montori, Victor M; Eton, David T

2014-01-01

47

Treatment of Complex Fistula in Ano with Cable-Tie Seton: A Prospective Case Series  

PubMed Central

Objective. To determine the fecal incontinence and recurrence rate in patients with complex fistula in ano managed with cable tie seton at a tertiary care teaching hospital. Methods. This is a prospective case series of patients with complex anal fistula i.e. recurrent fistula or encircling >30% of external anal sphincter, managed with cable tie seton from March 2003 to March 2009. Patients were seen in the clinic after 72 hours of seton insertion under anesthesia and then every other week. Each time the cable-tie was tightened if found loose without anesthesia and incontinence was inquired according to wexner's score. Results. Seventy nine patients were treated during the study period with the age (mean ± standard deviation) of 41 ± 10.6 years and. The seton was tightened with a median of six times (3–15 times range). Complete healing was achieved in 11.2 ± 5.7 weeks. All the patients were followed for a minimum period of one year and none of the patients had any incontinence. Recurrence was found in 4 (5%) patients. Conclusion. The cable tie seton is safe, cost effective and low morbidity option for the treatment of complex fistulae-in-ano. It can, therefore, be recommended as the standard of treatment for complex fistulae-in-ano requiring the placement of a seton. PMID:22084768

Memon, Ayaz Ahmad; Murtaza, Ghulam; Azami, Rizwan; Zafar, Hasnain; Chawla, Tabish; Laghari, Altaf Ali

2011-01-01

48

[Reflexotherapy combined with cortexin in the complex treatment of speech disorders in patients with cerebral palsy].  

PubMed

Authors studied 78 outpatients with children cerebral palsy, aged from 2 to 7 years, in the children department of neurology and reflexotherapy. All children had speech disorders of different severity: from a severe mental-speech deficit to muscle asinergia of the speech apparatus. Combined microcurrent reflexotherapy (MCRT) in the author's technique and the neuroprotector cortexin were used for treatment. The main group included 40 patients who received the treatment of MCRT in the combination with cortexin, the comparison group consisted of 38 patients who received only MCRT. MCRT consisted of 15 sessions with one month interval after the first treatment and two months after the second one. The treatment with cortexin included sessions of 10 injections each after the end of the first and the third MCRT sessions. Patient state was measured at baseline and at the end of 6 month treatment program. An analysis of results of the complex treatment demonstrated its high efficacy in the recovery of speech functions in children with cerebral palsy compared to patients of the comparison group. PMID:21946134

Ukhanova, T A; Gorbunov, F E; Ivanova, V V

2011-01-01

49

Pulsed radiofrequency treatment of complex regional pain syndrome: A case series  

PubMed Central

BACKGROUND: Various forms of sympathetic chain neurolysis (sympathectomy) have, at one time or another, held promise as effective treatment options for complex regional pain syndrome (CRPS). Complications, such as worsening pain and the development of new pain syndromes, have prevented sympathectomy from emerging as a standard intervention. In an effort to avoid poor outcomes associated with neurolysis, pulsed radiofrequency (PRF) has been proposed as a potential treatment alternative for a number of chronic neuropathic pain states, including some forms of CRPS. METHODS: The present report describes three cases in which patients diagnosed with lower extremity CRPS type I obtained substantial and lasting intervals of pain relief following PRF of the lumbar sympathetic chain. Over a period of four years, 14 fluoroscopically guided procedures using PRF lesioning of the lumbar sympathetic chain at L2, L3 and L4 were performed in three individuals with CRPS type I of the lower limb. Outcome measures included pre- and post-treatment self-reported pain and medication requirements. RESULTS: Substantial pain relief (>50%) was achieved in 91.7% of PRF applications at three months and 83.3% at six months, with some treatments resulting in persistent relief well beyond 12 months. Medication use decreased to a comparable degree, with discontinuation of opiates after all but three treatments. CONCLUSIONS: PRF lesioning of the lumbar sympathetic chain can be an effective treatment for patients with CRPS type I of the lower extremity, with the potential to provide ?6 months of substantial pain relief. PMID:24945285

Djuric, Vlad

2014-01-01

50

Amphiphilic Antimony(V) Complexes for Oral Treatment of Visceral Leishmaniasis  

PubMed Central

The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their potential for the oral treatment of visceral leishmaniasis (VL) was evaluated. Complexes of Sb and ligand at 1:3 (SbL8 and SbL10) were obtained from the reaction of antimony(V) with L8 and L10, as evidenced by elemental and electrospray ionization-tandem mass spectrometry (ESI-MS) analyses. Fluorescence probing of hydrophobic environment and negative-staining transmission electron microscopy showed that SbL8 forms kinetically stabilized nanoassemblies in water. Pharmacokinetic studies with mice in which the compound was administered by the oral route at 200 mg of Sb/kg of body weight indicated that the SbL8 complex promoted greater and more sustained Sb levels in serum and liver than the levels obtained for the conventional antimonial drug meglumine antimoniate (Glucantime [Glu]). The efficacy of SbL8 and SbL10 administered by the oral route was evaluated in BALB/c mice infected with Leishmania infantum after a daily dose of 200 mg of Sb/kg for 20 days. Both complexes promoted significant reduction in the liver and spleen parasite burdens in relation to those in the saline-treated control group. The extent of parasite suppression (>99.96%) was similar to that achieved after Glu given intraperitoneally at 80 mg of Sb/kg/day. As expected, there was no significant reduction in the parasitic load in the group treated orally with Glu at 200 mg of Sb/(kg day). In conclusion, amphiphilic antimony(V) complexes emerge as an innovative and promising strategy for the oral treatment of VL. PMID:23796930

Fernandes, Flaviana R.; Ferreira, Weverson A.; Campos, Mariana A.; Ramos, Guilherme S.; Kato, Kelly C.; Almeida, Gregorio G.; Correa, Jose D.; Melo, Maria N.; Demicheli, Cynthia

2013-01-01

51

Ammonium chloride complex formation during downstream microwave ammonia plasma treatment of parylene-C  

SciTech Connect

In this work, parylene-C is exposed to the effluent from a microwave ammonia plasma with a goal of producing primary amine groups on the parylene-C. These amine groups are desired as sites for the attachment of various biomolecules that will influence the biocompatibility of the parylene-C. Ammonia plasma treatment is an effective approach for creating amine species on polymers. In this work, attenuated total reflectance infrared spectroscopy studies showed that no primary amine groups resulted from this treatment of parylene-C. Instead, reactive nitrogen-bearing radicals from the plasma appear to have been complexed by chlorine in the polymer. The formation of these complexes scavenged nitrogen-bearing radicals from the plasma and prevented the formation of nitrogenous species, such as the desired primary amines, on the parylene-C. These results are consistent with results of ammonia plasma treatment of other chlorinated polymers and suggest that alternative approaches are required to create nitrogen-bearing species on parylene-C.

Pruden, K.G.; Beaudoin, S.P. [Department of Chemical and Materials Engineering, Arizona State University, Tempe, Arizona 85287-6006 (United States); Department of Chemical and Materials Engineering, Arizona State University, Tempe, Arizona 85287-6006 and School of Chemical Engineering, Purdue University, Forney Hall of Chemical Engineering, 480 Stadium Mall Drive, West Lafayette, Indiana 47907-2100 (United States)

2005-11-15

52

The assessment and treatment of a complex geriatric patient by an interprofessional primary care team  

PubMed Central

Mr K is an 89-year-old married man with a number of comorbid conditions and multiple recent falls. He was referred to the IMPACT clinic (Interprofessional Model of Practice for Aging and Complex Treatments) as his primary care physician was concerned about his declining health and the growing care giver burden on his wife. Mr K’s condition was deteriorating while the complexity of his case was increasing; therefore, an in-depth team assessment was sought to determine the best management plan and to assess his capacity to remain at home (his expressed preference). The IMPACT team met with Mr K and his wife for a 2 h interprofessional assessment. A comprehensive care plan was developed including specific recommendations for implementing change. After the visit to the IMPACT clinic, Mr K’s care was returned to his regular family physician. PMID:22698900

Bell, Stephanie H; Tracy, C Shawn; Upshur, Ross E G

2011-01-01

53

Treatment compliance and effectiveness in complex PTSD patients with co-morbid personality disorder undergoing stabilizing cognitive behavioral group treatment: a preliminary study  

PubMed Central

Background In the empirical and clinical literature, complex posttraumatic stress disorder (PTSD) and personality disorders (PDs) are suggested to be predictive of drop-out or reduced treatment effectiveness in trauma-focused PTSD treatment. Objective In this study, we aimed to investigate if personality characteristics would predict treatment compliance and effectiveness in stabilizing complex PTSD treatment. Method In a randomized controlled trial on a 20-week stabilizing group cognitive behavioral treatment (CBT) for child-abuse-related complex PTSD, we included 71 patients of whom 38 were randomized to a psycho-educational and cognitive behavioral stabilizing group treatment. We compared the patients with few PD symptoms (adaptive) (N=14) with the non-adaptive patients (N=24) as revealed by a cluster analysis. Results We found that non-adaptive patients compared to the adaptive patients showed very low drop-out rates. Both non-adaptive patients, classified with highly different personality profiles “withdrawn” and “aggressive,” were equally compliant. With regard to symptom reduction, we found no significant differences between subtypes. Post-hoc, patients with a PD showed lower drop-out rates and higher effect sizes in terms of complex PTSD severity, especially on domains that affect regulation and interpersonal problems. Conclusions Contrary to our expectations, these preliminary findings indicate that this treatment is well tolerated by patients with a variety of personality pathology. Larger sample sizes are needed to study effectiveness for subgroups of complex PTSD patients. PMID:24224077

Dorrepaal, Ethy; Thomaes, Kathleen; Smit, Johannes H.; Veltman, Dick J.; Hoogendoorn, Adriaan W.; van Balkom, Anton J. L. M.; Draijer, Nel

2013-01-01

54

[Efficiency of groprinosine in the complex treatment of acute virus hepatitis B].  

PubMed

35 patients with acute virus hepatitis of average severity were examined. They developed after short-term improvement of general state a negative dynamics of clinical and laboratory indexes. 21 patients have received traditional treatment, 14 patients additionally were prescribed groprinosine in a dose of 50 mg/kg daily per/os within 5-10 days. It was shown, that addition of gropfmosme to complex therapy positively influenced on the disease's course, promoted a rapid regress of clinical symptoms, normalization of biochemical indexes of liver's functions and decreased days of hospitalization. PMID:15724621

Karimov, I Z

2004-01-01

55

Treatment of the Atrophic Upper Jaw: Rehabilitation of Two Complex Cases  

PubMed Central

In reconstructive surgery, the fresh frozen homologous bone (FFB) represents a valid alternative to the autologous bone, because FFB allows bone regeneration thanks to its osteoinductive and osteoconductive properties. The purpose of this work is to describe the surgical-implant-prosthetic treatment of two complex cases using FFB. In particular, fresh frozen homologous bone grafts were used to correct the severe atrophy of the maxilla, and, then, once the graft integration was obtained, implant therapy was performed and implants placed in native bone were immediately loaded. PMID:23984108

Borgonovo, Andrea Enrico; Marchetti, Andrea; Vavassori, Virna; Censi, Rachele; Boninsegna, Ramon

2013-01-01

56

Treatment of the atrophic upper jaw: rehabilitation of two complex cases.  

PubMed

In reconstructive surgery, the fresh frozen homologous bone (FFB) represents a valid alternative to the autologous bone, because FFB allows bone regeneration thanks to its osteoinductive and osteoconductive properties. The purpose of this work is to describe the surgical-implant-prosthetic treatment of two complex cases using FFB. In particular, fresh frozen homologous bone grafts were used to correct the severe atrophy of the maxilla, and, then, once the graft integration was obtained, implant therapy was performed and implants placed in native bone were immediately loaded. PMID:23984108

Borgonovo, Andrea Enrico; Marchetti, Andrea; Vavassori, Virna; Censi, Rachele; Boninsegna, Ramon; Re, Dino

2013-01-01

57

[Clinical course and surgical treatment of complex forms of recurrent acute paraproctitis].  

PubMed

Clinical course and results of surgical treatment of 94 patients with complex forms of recurrent acute paraproctitis were analysed. Radical surgical intervention was conducted in 68 patients, of whom in 35--using the pararectal abscess opening with cryptectomy, in 17--with translocation of a distal rectum mucosa, in 16--with a ligature conduction through internal aperture of fistula. One-nine year follow-up of 89 patients is available. After radical intervention the recurrence and postoperative complications had occurred in 19%, after nonradical one--in all the patients. PMID:10370291

Stavitski?, V V

1999-01-01

58

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.  

PubMed

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage T. b. rhodesiense infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-?-cyclodextrin and melarsoprol randomly-methylated-?-cyclodextrin. We found that these compounds retain trypanocidal properties in vitro and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy. PMID:21909447

Rodgers, Jean; Jones, Amy; Gibaud, Stéphane; Bradley, Barbara; McCabe, Christopher; Barrett, Michael P; Gettinby, George; Kennedy, Peter G E

2011-09-01

59

Partial rupture of the hamstring muscle complex: a literature review on treatment options.  

PubMed

Injuries of the hamstring muscle complex (HMC) often affect athletes participating in specific sporting activities. Mild injuries that constitute a mere strain of the muscle can be managed symptomatically, while severe injuries often require surgical intervention to precipitate a return to function. Neglected injuries usually result in a long-term functional impairment. Therefore, surgical reconstruction of the HMC is advised for both partial and complete lesions. Without acute repair, a chronic lesion referred to as hamstring syndrome can result due to dysfunction of the HMC. Surgical intervention is usually recommended. A case of a chronic severe partial injury to the HMC managed conservatively in a 49-year old female is presented to illustrate the level of function that can be achieved after non-operative management. The clinical and radiological findings are presented 18 months post-injury along with a review of the current literature. There are no previous reports in the literature describing this scenario. This case indicates the need for re-evaluation in treatment options in partial hamstring muscle ruptures. A surgical treatment of partial rupture should be considered more often as an adequate treatment option and cofactors that influence the prognosis must be revealed. The indication of surgical intervention should be re-evaluated within the first months in case of conservative treatment. PMID:24077940

Horst, Klemens; Dienstknecht, T; Sellei, R M; Pape, H C

2014-04-01

60

[Complex treatment of a large radicular cyst due to traumatic dental injury--a case report].  

PubMed

A 28-year-old male came to the clinic for control visit and scaling. Panoramic radiograph was taken before any treatment. The radiograph revealed a large size periapical lesion extending from the lower right first premolar to the lower left canine. History of dental trauma in childhood was recorded. The asymptomatic, injured teeth were not treated by dentist. Upon clinical examination a discolored lower right central incisor and more teeth with pulpal necrosis were found. After the endodontic treatments a cystostomy was performed. Obturator was used by the patient in the healing period. The success of complex treatment is proven by the highly recovered bone forming shown during the regular recalls. For the correct diagnosis and planning of the complete treatment dentist should be careful on general- and dental anamnesis and complete clinical and radiographic examination. Small clinical signs and pathoses should alert the dentist. This case is a reminder that the careful anamnesis, clinical examination and early diagnosis of any pathosis are very important. PMID:24812750

Demeter, Andrea; Bogdán, Sándor; Tóth, Zsuzsanna; Nemes, Júlia

2014-03-01

61

Relationship between clinical efficacy of treatment of pulmonary Mycobacterium avium complex disease and drug-sensitivity testing of Mycobacterium avium complex isolates  

Microsoft Academic Search

We prospectively investigated the relationship between the clinical efficacy of treatment of pulmonary Mycobacterium avium complex (MAC) disease and drug-sensitivity testing of MAC isolates for antituberculous drugs, new quinolone antibiotics,\\u000a and clarithromycin (CAM). Fifty-two patients who satisfied the diagnostic criteria of the American Thoracic Society (ATS)\\u000a and who received treatment between April 1998 and December 2005, using combined therapy of

Yoshihiro Kobashi; Kouichiro Yoshida; Naoyuki Miyashita; Yoshihito Niki; Mikio Oka

2006-01-01

62

Enhancement of Auditory Fear Conditioning after Housing in a Complex Environment Is Attenuated by Prior Treatment with Amphetamine  

ERIC Educational Resources Information Center

Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages normally associated with living in a complex environment. To test this hypothesis we examined the influence of prior exposure to amphetamine on fear…

Briand, Lisa A.; Robinson, Terry E.; Maren, Stephen

2005-01-01

63

Predicting Stabilizing Treatment Outcomes for Complex Posttraumatic Stress Disorder and Dissociative Identity Disorder: An Expertise-Based Prognostic Model  

Microsoft Academic Search

The purpose of this study was to develop an expertise-based prognostic model for the treatment of complex posttraumatic stress disorder (PTSD) and dissociative identity disorder (DID). We developed a survey in 2 rounds: In the first round we surveyed 42 experienced therapists (22 DID and 20 complex PTSD therapists), and in the second round we surveyed a subset of 22

Erik W. Baars; Onno van der Hart; Ellert R. S. Nijenhuis; James A. Chu; Gerrit Glas; Nel Draijer

2010-01-01

64

Effect of complex treatment using visual and auditory stimuli on the symptoms of attention deficit/hyperactivity disorder in children  

PubMed Central

We investigated the effects of complex treatment using visual and auditory stimuli on the symptoms of attention deficit/hyperactivity disorder (ADHD) in children. Forty-seven male children (7–13 yr old), who were clinically diagnosed with ADHD at the Balance Brain Center in Seoul, Korea, were included in this study. The complex treatment consisted of visual and auditory stimuli, core muscle exercise, targeting ball exercise, ocular motor exercise, and visual motor integration. All subjects completed the complex treatment for 60 min/day, 2–3 times/week for more than 12 weeks. Data regarding visual and auditory reaction time and cognitive function were obtained using the Neurosync program, Stroop Color-Word Test, and test of nonverbal intelligence (TONI) at pre- and post-treatment. The complex treatment significantly decreased the total reaction time, while it increased the number of combo actions on visual and auditory stimuli (P< 0.05). The Stroop color, word, and color-word scores were significantly increased at post-treatment compared to the scores at pretreatment (P< 0.05). There was no significant change in the TONI scores, although a tendency toward an increase in these scores was observed. In conclusion, complex treatment using visual and auditory stimuli alleviated the symptoms of ADHD and improved cognitive function in children. In addition, visual and auditory function might be possible indicators for demonstrating effective ADHD intervention. PMID:24278878

Park, Mi-Sook; Byun, Ki-Won; Park, Yong-Kyung; Kim, Mi-Han; Jung, Sung-Hwa; Kim, Hong

2013-01-01

65

Treatment of complex infantile haemangioma in a resource-poor setting.  

PubMed

Infantile haemangiomas affect approximately 5% of the population and usually do not require treatment. However, complex cutaneous haemangiomas can cause disabling disfigurement, while haemangiomas in the brain, airway or gastrointestinal tract can cause life-threatening complications. Although children with infantile haemangiomas are often first brought to general practitioners and paediatricians by parents for care, they are thought of as a surgical problem and usually referred to specialty care. We present a case of an infant from a resource-poor setting in rural Indonesia with disfiguring facial haemangiomas, as well as a probable airway haemangioma causing stridor at rest. The infant was treated with oral propranolol with marked involution of the cutaneous haemangioma, resolution of stridor and increase in weight. PMID:25053694

Natawidjaja, Ronald; Wang, Ewen

2014-01-01

66

Complex Diagnostic and Treatment Issues in Psychotic Symptoms Associated with Narcolepsy  

PubMed Central

Narcolepsy is an uncommon chronic, neurological disorder characterized by abnormal manifestations of rapid eye movement sleep and perturbations in the sleep-wake cycle. Accurate diagnosis of psychotic symptoms in a person with narcolepsy could be difficult due to side effects of stimulant treatment (e.g., hallucinations) as well as primary symptoms of narcolepsy (e.g., sleep paralysis and hypnagogic and/or hypnapompic hallucinations). Pertinent articles from peer-reviewed journals were identified to help understand the complex phenomenology of psychotic symptoms in patients with narcolepsy. In this ensuing review and discussion, we present an overview of narcolepsy and outline diagnostic and management approaches for psychotic symptoms in patients with narcolepsy. PMID:19724760

Ivanenko, Anna

2009-01-01

67

Treatment of Uncertainties: Output Updating in Complex Thermal-Hydraulics (TH) Computational Codes  

SciTech Connect

Uncertainty analysis methodology in complex system models requires a comprehensive treatment of many different types and sources of uncertainty sources. Proposed methodology as part of a broader research by the authors for an integrated methodology for uncertainty analysis of TH computational codes, allows updating of uncertainties upon availability of new information about inputs, models or output. This methodology is a statistical approach for output-based updating, with non-paired data. The proposed method employs a Gibbs MCMC sampler to estimate output distribution. Winbugs code was developed to implement the Bayesian solution proposed in this paper. The methodology is applied to the data from 200% cold leg LBLOCA test of LOFT facility. (authors)

Pourgol-Mohamad, Mohammad; Mosleh, Ali; Modarres, Mohammad [University of Maryland, College Park, MD 20742 (United States)

2006-07-01

68

Low-intensity laser radiation in complex treatment of inflammatory diseases of parodontium  

NASA Astrophysics Data System (ADS)

The problem of complex treatment of inflammatory disease of parodontium has become very acute and actual at the moment. The diseases of inflammatory nature are considered to be the most vital issues of the day. The state of the local immune system of oral cavity plays the most important role in the complicated mechanism of inflammatory process development in the tissues of parodontium. Recently physical factors have become predominant in the system of complex therapy of parodontitis. The application of low-intense laser radiation (LLR) is considered to be the most important and up-to-date method in the preventive dentistry. There were 60 patients of average damage rate suffering from chronic generalizing parodontitis at the age of 25 up to 55 under observation. The major goal of examination was to get the objective results of the following methods' application: parodontium index (Russel, 1956), hygiene index (Fyodorov, Volodkina, 1971), Bacterioscopy of dental-gingival pockets content, simple and broadened stomatoscopy (Kunin, 1970), SIgA level determination in mixed saliva (Manchini et all, 1965) and R-protein level in gingival blood (Kulberg, 1990). All the patients were split into 2 groups. The first group (30 patients) has undergone the laser therapy course while the second group of 30 patients couldn't get it (LLR). Despite the kind of therapy they have undergone, all the patients have got the local anti-inflammatory medicamental therapy. The results of clinical observations have proved the fact that laser therapy application makes it possible to shorten the course of treatment in 1.5 times. The shifts of oral cavity local resistance take place in case of chronic generalizing parodontitis. The direct immunostimulating effect could be observed as a result of LLR- therapy application. The close connection of both anti-inflammatory medicamental and LLR-therapy has proved the possibility of purposeful local immune status correction in case of parodontitis.

Sokolova, Irina A.; Erina, Stanislava V.

1995-04-01

69

Tailoring fly ash activated with bentonite as adsorbent for complex wastewater treatment  

NASA Astrophysics Data System (ADS)

Used as adsorbent, alkali fly ash represents a low cost solution for advanced wastewater treatment. The alkali treatment raises sustainability issues therefore, in this research we aim to replace alkali fly ash with washed fly ash (FAw). For improving the adsorption capacity of washed fly ash, bentonite powder (B) was added, as a natural adsorbent with a composition almost identical to the fly ash. The new adsorbent was characterized by AFM, XRD, FTIR, SEM, EDS and the surface energy was evaluated by contact angle measurements. For understanding the complex adsorption process on this mixed substrate, preliminary tests were developed on synthetic wastewaters containing a single pollutant system (heavy metal), binary (two-heavy metals) and ternary (dye and two heavy metals) systems. Experiments were done on synthetic wastewaters containing methylene blue, cadmium and copper, using FAw, B and their powder mixtures. The pseudo-second order kinetics could well model all the processes, indicating a good adsorbent material which can be used for the pollutants removal from wastewater. After adsorption the substrates loaded with pollutants, annealed at 500 °C can be reused for padding in stone blocks.

Visa, Maria

2012-12-01

70

Treatment with at Homeopathic Complex Medication Modulates Mononuclear Bone Marrow Cell Differentiation  

PubMed Central

A homeopathic complex medication (HCM), with immunomodulatory properties, is recommended for patients with depressed immune systems. Previous studies demonstrated that the medication induces an increase in leukocyte number. The bone marrow microenvironment is composed of growth factors, stromal cells, an extracellular matrix and progenitor cells that differentiate into mature blood cells. Mice were our biological model used in this research. We now report in vivo immunophenotyping of total bone marrow cells and ex vivo effects of the medication on mononuclear cell differentiation at different times. Cells were examined by light microscopy and cytokine levels were measured in vitro. After in vivo treatment with HCM, a pool of cells from the new marrow microenvironment was analyzed by flow cytometry to detect any trend in cell alteration. The results showed decreases, mainly, in CD11b and TER-119 markers compared with controls. Mononuclear cells were used to analyze the effects of ex vivo HCM treatment and the number of cells showing ring nuclei, niche cells and activated macrophages increased in culture, even in the absence of macrophage colony-stimulating factor. Cytokines favoring stromal cell survival and differentiation in culture were induced in vitro. Thus, we observe that HCM is immunomodulatory, either alone or in association with other products. PMID:19736221

Cesar, Beatriz; Abud, Ana Paula R.; de Oliveira, Carolina C.; Cardoso, Francolino; Bernardi, Raffaello Popa Di; Guimaraes, Fernando S. F.; Gabardo, Juarez; de Freitas Buchi, Dorly

2011-01-01

71

Autologous chondrocyte implantation (ACI) for the treatment of large and complex cartilage lesions of the knee  

PubMed Central

Background Complex cartilage lesions of the knee including large cartilage defects, kissing lesions, and osteoarthritis (OA) represent a common problem in orthopaedic surgery and a challenging task for the orthopaedic surgeon. As there is only limited data, we performed a prospective clinical study to investigate the benefit of autologous chondrocyte implantation (ACI) for this demanding patient population. Methods Fifty-one patients displaying at least one of the criteria were included in the present retrospective study: (1.) defect size larger than 10 cm2; (2.) multiple lesions; (3.) kissing lesions, cartilage lesions Outerbridge grade III-IV, and/or (4.) mild/moderate osteoarthritis (OA). For outcome measurements, the International Cartilage Society's International Knee Documentation Committee's (IKDC) questionnaire, as well as the Cincinnati, Tegner, Lysholm and Noyes scores were used. Radiographic evaluation for OA was done using the Kellgren score. Results and Discussion Patient's age was 36 years (13-61), defects size 7.25 (3-17.5) cm2, previous surgical procedures 1.94 (0-8), and follow-up 30 (12-63) months. Instruments for outcome measurement indicated significant improvement in activity, working ability, and sports. Mean ICRS grade improved from 3.8 preoperatively to grade 3 postoperatively, Tegner grade 1.4 enhanced to grade 3.39. The Cincinnati score enhanced from 25.65 to 66.33, the Lysholm score from 33.26 to 64.68, the Larson score from 43.59 to 79.31, and Noyes score from 12.5 to 46.67, representing an improvement from Cincinnati grade 3.65 to grade 2.1. Lysholm grade 4 improved to grade 3.33, and Larson grade 3.96 to 2.78 (Table 1), (p < 0.001). Patients with kissing cartilage lesions had similar results as patients with single cartilage lesions. Table 1 Mean scores and grades at surgery (Tx) and at follow-up Tx Follow-up Score Grade Score Grade ICRS 4 3 Tegner 1 3 Noyes 13 47 Cincinnati 26 4 66 2 Lysholm 33 4 65 3 Larson 44 4 79 3 Conclusion Our results suggest that ACI provides mid-term results in patients with complex cartilage lesions of the knee. If long term results will confirm our findings, ACI may be a considered as a valuable tool for the treatment of complex cartilage lesions of the knee. PMID:21599992

2011-01-01

72

Heart Failure with a Normal Ejection Fraction: Treatments for a Complex Syndrome?  

PubMed Central

Opinion statement Heart failure with a normal ejection fraction (HFNEF) now comprises more than 50% of all patients with heart failure. As the population ages, HFNEF will continue to be a growing public health problem. Recent studies highlight the heterogeneity of this syndrome with regards to underlying pathophysiologic mechanisms. It has been recognized that multiple physiologic domains of cardiovascular function are abnormal in afflicted subjects resulting in a reduced reserve capacity which contributes in an integrated fashion to produce the observed phenotype. Additionally, the realization that differing aspects of this syndrome (e.g. exercise limitations, pulmonary edema and labile blood pressure) likely each have distinct physiologic causes further adds to the complexity. As a result of the heterogeneous nature of the pathophysiologic processes and comorbid illnesses in this population, there is a wide range of clinical outcomes. Accordingly, appreciation of the global nature of HFNEF will ideally better inform optimal design for future diagnostic and therapeutic strategies. Completed clinical trials have not resulted in any evidence-based treatments available for improving survival. Given the disappointing results of these investigations, there has been renewed interest in developing interventions that target underlying comorbidities and peripheral mechanisms. Additionally, non-pharmacologic interventions such as diet and exercise have shown promise in early, small clinical investigations. Finally, methods to more rationally subgroup patients in order to identify cohorts who could respond to targeted intervention are essential. Recognizing the success achieved in the treatment of systolic heart failure, or heart failure with a reduced ejection fraction (HFREF) by addressing neurohormonal and renal mechanisms, new therapies for HFNEF may be achieved by a similar shift in attention away from the heart. PMID:22660923

Bernard, Samuel; Maurer, Mathew S.

2012-01-01

73

Successful treatment of complex traumatic and surgical wounds with a foetal bovine dermal matrix.  

PubMed

A foetal bovine dermal repair scaffold (PriMatrix, TEI Biosciences) was used to treat complex surgical or traumatic wounds where the clinical need was to avoid skin flaps and to build new tissue in the wound that could be reepithelialised from the wound margins or closed with a subsequent application of a split-thickness skin graft (STSG). Forty-three consecutive cases were reviewed having an average size of 79·3 cm(2) , 50% of which had exposed tendon and/or bone. In a subset of wounds (44·7%), the implantation of the foetal dermal collagen scaffold was also augmented with negative pressure wound therapy (NPWT). Complete wound healing was documented in over 80% of the wounds treated, whether the wound was treated with the foetal bovine dermal scaffold alone (95·2%) or when supplemented with NPWT (82·4%). The scaffold successfully incorporated into wounds with exposed tendon and/or bone to build vascularised, dermal-like tissue. The new tissue in the wound supported STSGs however, in the majority of the cases (88·3%); wound closure was achieved through reepithelialisation of the incorporated dermal scaffold by endogenous wound keratinocytes. The foetal bovine dermal repair scaffold was found to offer an effective alternative treatment strategy for definitive closure of challenging traumatic or surgical wounds on patients who were not suitable candidates for tissue flaps. PMID:23452161

Hayn, Ernesto

2014-12-01

74

MA THELU -18/02/2010 J Medical Virology 1 IRES Complexity before IFN-alpha treatment and  

E-print Network

MA THELU - 18/02/2010 J Medical Virology 1 IRES Complexity before IFN-alpha treatment and Evolution in "Journal of Medical Virology 2007;79(3):242-53" DOI : 10.1002/jmv.20792 #12;MA THELU - 18/02/2010 J Medical Virology 2 INTRODUCTION Hepatitis C Virus (HCV) is one of the major causative agent of chronic hepatitis

Boyer, Edmond

75

Calcium channel blockers as first line treatment for broad complex tachycardia with right bundle branch block: ingenuity or folly?  

Microsoft Academic Search

Objective: To study the response of regular broad-complex tachycardia (BCT) demonstrating right bundle branch block (RBBB) to treatment in the Emergency department (ED). Methods: Retrospective chart review of management of patients with BCT, RBBB without a history of ischaemic heart disease. A diagnosis of ventricular tachycardia (VT) was made if the ECG showed features such as atrioventricular dissociation, capture or

Jenn Chyuan Wang; Swee Han Lim; Wee Siong Teo; V Anantharaman

2002-01-01

76

Computer-aided patch planning for treatment of complex coarctation of the aorta  

NASA Astrophysics Data System (ADS)

Between five and eight percent of all children born with congenitally malformed hearts suffer from coarctations of the aorta. Some severe coarctations can only be treated by surgical repair. Untreated, this defect can cause serious damage to organ development or even lead to death. Patch repair requires open surgery. It can affect patients of any age: newborns with severe coarctation and/or hypoplastic aortic arch as well as older patients with late diagnosis of coarctation of the aorta. Another patient group are patients of varying age with re-coarctation of the aorta or hypoplastic aortic arch after surgical and/or interventional repair. If anatomy is complex and interventional treatment by catheterization, balloon angioplasty or stent placement is not possible, surgery is indicated. The choice of type of surgery depends not only on the given anatomy but also on the experience the surgical team has with each method. One surgical approach is patch repair. A patch of a suitable shape and size is sewed into the aorta to expand the aortic lumen at the site of coarctation. At present, the shape and size of the patch are estimated intra-operatively by the surgeon. We have developed a software application that allows planning of the patch pre-operatively on the basis of magnetic resonance angiographic data. The application determines the diameter of the coarctation and/or hypoplastic segment and constructs a patch proposal by calculating the difference to the normal vessel diameter pre-operatively. Evaluation of MR angiographic datasets from 12 test patients with different kinds of aortic arch stenosis shows a divergence of only (1.5+/-1.2) mm in coarctation diameters between manual segmentations and our approach, with comparable time expenditure. Following this proposal the patch can be prepared and adapted to the patient's anatomy pre-operatively. Ideally, this leads to shorter operation times and a better long-term outcome with a reduced rate of residual stenosis and re-stenosis and aneurysm formation.

Rietdorf, Urte; Riesenkampff, Eugénie; Kuehne, Titus; Huebler, Michael; Meinzer, Hans-Peter; Wolf, Ivo

2009-02-01

77

Ruthenium Complex with Benznidazole and Nitric Oxide as a New Candidate for the Treatment of Chagas Disease  

PubMed Central

Background Chagas disease remains a serious medical and social problem in Latin America and is an emerging concern in nonendemic countries as a result of population movement, transfusion of infected blood or organs and congenital transmission. The current treatment of infected patients is unsatisfactory due to strain-specific drug resistance and the side effects of the current medications. For this reason, the discovery of safer and more effective chemotherapy is mandatory for the successful treatment and future eradication of Chagas disease. Methods and Findings We investigated the effect of a ruthenium complex with benznidazole and nitric oxide (RuBzNO2) against Trypanosoma cruzi both in vitro and in vivo. Our results demonstrated that RuBzNO2 was more effective than the same concentrations of benznidazole (Bz) in eliminating both the extracellular trypomastigote and the intracellular amastigote forms of the parasite, with no cytotoxic effect in mouse cells. In vivo treatment with the compound improved the survival of infected mice, inhibiting heart damage more efficiently than Bz alone. Accordingly, tissue inflammation and parasitism was significantly diminished after treatment with RuBzNO2 in a more effective manner than that with the same concentrations of Bz. Conclusions The complexation of Bz with ruthenium and nitric oxide (RuBzNO2) increases its effectiveness against T. cruzi and enables treatment with lower concentrations of the compound, which may reduce the side effects of Bz. Our findings provide a new potential candidate for the treatment of Chagas disease. PMID:25275456

Sesti-Costa, Renata; Carneiro, Zumira A.; Silva, Maria C.; Santos, Maita; Silva, Grace K.; Milanezi, Cristiane; da Silva, Roberto S.; Silva, Joao S.

2014-01-01

78

Autologous fibrin glue in the treatment of rectovaginal and complex fistulas  

Microsoft Academic Search

This nonrandomized series reports the use of autologous fibrin glue to treat complex rectovaginal and anorectal fistulas. The use of an autologous source to prepare fibrin glue eliminates the risk of disease transmission. Ten patients, six women and four men, with complex fistulas were treated with autologous fibrin glue application. Five patients had rectovaginal fistulas; one of them had Crohn's

Michael E. Abel; Yanek S. Y. Chiu; Thomas R. Russell; Peter A. Volpe

1993-01-01

79

Synthesis, chemical and biological studies on new Fe 3+-glycosilated ?-diketo complexes for the treatment of iron deficiency  

Microsoft Academic Search

A simple synthetic pathway to obtain glycosilated ?-diketo derivatives is proposed. These compounds show a good iron(III) affinity therefore we may suggest the use of their Fe3+-complexes as oral iron supplements in the treatment of anaemia. The glycosilated compounds (6-GlcH, 6-GlcOH and 6-GlcOCH3) are characterized by means of spectroscopic (UV, 1H and 13C NMR) and potentiometric techniques; they have a

Beatrice Arezzini; Marco Ferrali; Erika Ferrari; Chiara Frassineti; Sandra Lazzari; Gaetano Marverti; Ferdinando Spagnolo; Monica Saladini

2008-01-01

80

Minimization of round-off error and treatment of single phase and separated components in conventional and complex columns  

E-print Network

MINIMIZATION OF ROUND-OFF ERROR AND TREATMENT OF SINGLE PHASE AND SEPARATED COMPONENTS IN CONVENTIONAL AND COMPLEX COLUMNS A Thesis By Andrew Jacobs Weisenfelder Submitted to the Graduate School of the Agricultural and Mechanical College... COLUMNS A Thesis By Andrew Jacobs Weisenfelder Approved as to style and content by: Chairman of Committee Head of pa nt May l961 ACKNOWLEDGEMENT The author wishes to gratefully acknowledge the financial assistance given by Humble Oil and Refining...

Weisenfelder, Andrew J

2012-06-07

81

Dose calculation methodology for irradiation treatment of complex-shaped foods  

E-print Network

of the treated product falls within some specified range. The Monte Carlo electron transport simulation and computer tomography (CT) scan technology were used to predict the dose distribution in complex shaped foods, an apple phantom composed of paraffin wax...

Kim, Jongsoon

2009-06-02

82

A New XRCC1-Containing Complex and Its Role in Cellular Survival of Methyl Methanesulfonate Treatment  

Microsoft Academic Search

DNA single-strand break repair (SSBR) is important for maintaining genome stability and homeostasis. The current SSBR model derived from an in vitro-reconstituted reaction suggests that the SSBR complex mediated by X-ray repair cross-complementing protein 1 (XRCC1) is assembled sequentially at the site of damage. In this study, we provide biochemical data to demonstrate that two preformed XRCC1 protein complexes exist

Hao Luo; Doug W. Chan; Tao Yang; Maria Rodriguez; Benjamin Ping-Chi Chen; Mei Leng; Jung-Jung Mu; David Chen; Zhou Songyang; Yi Wang; Jun Qin

2004-01-01

83

Typicality of Inanimate Category Exemplars in Aphasia Treatment: Further Evidence for Semantic Complexity  

ERIC Educational Resources Information Center

Purpose: The typicality treatment approach on improving naming was investigated within 2 inanimate categories ("furniture" and "clothing") using a single-subject experimental design across participants and behaviors in 5 patients with aphasia. Method: Participants received a semantic feature treatment to improve naming of either typical or…

Kiran, Swathi

2008-01-01

84

Towards a density functional treatment of chemical reactions in complex media  

SciTech Connect

We discuss two techniques involving density functional theory (i.e., ab initio molecular dynamics simulations and frozen density functional theory) which show promise for applications directed towards understanding reactions in complex media. Preliminary results for the simulation of the conformational dynamics of an isolated analogue of alanine dipeptide and for the interaction between F{sup -} and H{sub 2}O are included. These results represent the first steps towards a combined theoretical approach of reactions in complex media. 23 refs., 4 figs.

Berard, D.R.; Wei, D. [Centre de Recherche en Calcul Applique, Montreal, Quebec (Canada); Salahub, D.R. [Universite de Montreal, Quebec (Canada); [Centre de Recherche en Calcul Applique, Montreal, Quebec (Canada)

1996-12-31

85

Operations management for solid waste treatment Development of a system for modelling complex facilities  

Microsoft Academic Search

The most recent targets of the European Union - to increase the recovery of bulk materials from post-consumer waste and start up the recycling of the specialty elements (1) - are likely to result in more complex and more capital-intensive material recovery plants than are operated today. Even today, recycling facilities are difficult plants to manage, for almost every aspect

W. Kuilman; P. C. Rem; R. B. Leeftink

86

Phase-Oriented Treatment of Structural Dissociation in Complex Traumatization: Overcoming Trauma-Related Phobias  

Microsoft Academic Search

The theory of structural dissociation of the personality proposes that patients with complex trauma-related disorders are characterized by a division of their personality into different prototypical parts, each with its own psychobiological underpinnings. As one or more “apparently normal” parts (ANPs), patients have a propensity toward engaging in evolutionary prepared action systems for adaptation to daily living to guide their

Kathy Steele; Onno van der Hart; Ellert R. S. Nijenhuis

2005-01-01

87

Complex I Disorders: Causes, Mechanisms, and Development of Treatment Strategies at the Cellular Level  

ERIC Educational Resources Information Center

Mitochondrial oxidative phosphorylation (OXPHOS) represents the final step in the conversion of nutrients into cellular energy. Genetic defects in the OXPHOS system have an incidence between 1:5,000 and 1:10,000 live births. Inherited isolated deficiency of the first complex (CI) of this system, a multisubunit assembly of 45 different proteins,…

Valsecchi, Federica; Koopman, Werner J. H.; Manjeri, Ganesh R.; Rodenburg, Richard J.; Smeitink, Jan A. M.; Willems, Peter H. G. M.

2010-01-01

88

Multi-Day Low Dose Ketamine Infusion for the Treatment of Complex Regional Pain Syndrome  

Microsoft Academic Search

Background: Complex regional pain syndrome (CRPS) is characterized by pain that is out of proportion to the injury and is regional in distribution. A large body of litera- ture supports a dynamic change in the physi- ology and structure of central pain projecting neurons mediated through the N-methyl-D- aspartate (NMDA) receptor. A critical factor in central sensitization seems to be

Michael E. Goldberg; Richard Domsky; Denise Scaringe; Robert Hirsh; Jessie Dotson; Imran Sharaf; Marc C. Torjman; Robert J. Schwartzman

2005-01-01

89

Intermittent pneumatic compression acts synergistically with manual lymphatic drainage in complex decongestive physiotherapy for breast cancer treatment-related lymphedema.  

PubMed

The application of intermittent pneumatic compression (IPC) as a part of complex decongestive physiotherapy (CDP) remains controversial. The aim of this study was to investigate whether the combination of IPC with manual lymph drainage (MLD) could improve CDP treatment outcomes in women with secondary lymphedema after breast cancer treatment. A randomized study was undertaken with 13 subjects receiving MLD (60 min) and 14 receiving MLD (30 min) plus IPC (30 min) followed by standardized components of CDP including multilayered compression bandaging, physical exercise, and skin care 10 times in a 2-week-period. Efficacy of treatment was evaluated by limb volume reduction and a subjective symptom questionnaire at end of the treatment, and one and two months after beginning treatment. The two groups had similar demographic and clinical characteristics. Mean reductions in limb volumes for each group at the end of therapy, and at one and two months were 7.93% and 3.06%, 9.02% and 2.9%, and 9.62% and 3.6%, respectively (p < 0.05 from baseline for each group and also between groups at each measurement). Although a significant decrease in the subjective symptom survey was found for both groups compared to baseline, no significant difference between the groups was found at any time point. The application of IPC with MLD provides a synergistic enhancement of the effect of CDP in arm volume reduction. PMID:20218087

Szolnoky, G; Lakatos, B; Keskeny, T; Varga, E; Varga, M; Dobozy, A; Kemény, L

2009-12-01

90

Time-dependent reduction of structural complexity of the buccal epithelial cell nuclei after treatment with silver nanoparticles.  

PubMed

Recent studies have suggested that silver nanoparticles (AgNPs) may affect cell DNA structure in in vitro conditions. In this paper, we present the results indicating that AgNPs change nuclear complexity properties in isolated human epithelial buccal cells in a time-dependent manner. Epithelial buccal cells were plated in special tissue culture chamber / slides and were kept at 37°C in an RPMI 1640 cell culture medium supplemented with L-glutamine. The cells were treated with colloidal silver nanoparticles suspended in RPMI 1640 medium at the concentration 15 mg L?¹. Digital micrographs of the cell nuclei in a sample of 30 cells were created at five different time steps: before the treatment (controls), immediately after the treatment, as well as 15 , 30 and 60 min after the treatment with AgNPs. For each nuclear structure, values of fractal dimension, lacunarity, circularity, as well as parameters of grey level co-occurrence matrix (GLCM) texture, were determined. The results indicate time-dependent reduction of structural complexity in the cell nuclei after the contact with AgNPs. These findings further suggest that AgNPs, at concentrations present in today's over-the-counter drug products, might have significant effects on the cell genetic material. PMID:24118045

Pantic, I; Paunovic, J; Perovic, M; Cattani, C; Pantic, S; Suzic, S; Nesic, D; Basta-Jovanovic, G

2013-12-01

91

The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance  

PubMed Central

Cancer is a genetic disease, grows exponentially with the development of intrinsic and acquired treatment resistance. Past decade has witnessed a considerable progress towards the treatment and understanding of proposed hallmarks of cancer and together with advances in early detection and various treatment modalities. Radiation therapy is an integral part of cancer treatment armamentarium. In developed countries more than half of all cancer patients receive radiation therapy during their course of illness. Although radiation damages both cancer and normal cells, the goal of radiation therapy is to maximize the radiation dose to abnormal cancer cells while minimizing exposure to normal cells, which is adjacent to cancer cells or in the path of radiation. In recent years, life expectancy increases among cancer patients and this increase is due to the results of early diagnosis, screening efforts, improved treatments and with less late effects mostly secondary cancer development. Therefore, cancer survivorship issues have been gaining prominence in the area of radiation oncology research. Understanding the tradeoff between the expected decreases in normal tissue toxicity resulting from an improved radiation dose distribution to the targeted site is an increasingly pertinent, yet needed attention and research in the area of radiation oncology. In recent years, a number of potential molecular targets that involve either with radiation increased tumor cell killing or protecting normal cells have been identified. For clinical benefits, translating these findings to maximize the toxicity of radiation on tumor cells while safeguarding early or late normal cell toxicities using molecular targeted radioprotectors will be useful in radiation treatment. PMID:22860229

Baskar, Rajamanickam; Yap, Swee Peng; Chua, Kevin Lee Min; Itahana, Koji

2012-01-01

92

Fibrin glue treatment of complex anal fistulas has low success rate  

Microsoft Academic Search

Purpose: Fibrin glue has been used to treat anal fistulas in an attempt to avoid more radical surgical intervention. Reported\\u000a success rates vary widely. The purpose of this study was to review the use of fibrin glue in the management of complex anal\\u000a fistulas at a tertiary referral center. Methods: This study was designed as a retrospective review of all

Rasmy Loungnarath; David W. Dietz; Matthew G. Mutch; Elisa H. Birnbaum; Ira J. Kodner; James W. Fleshman

2004-01-01

93

Mirror visual feedback for the treatment of complex regional pain syndrome (type 1)  

Microsoft Academic Search

Mirror visual feedback was originally devised as a therapeutic tool to relieve perceived involuntarily movements and paralysis\\u000a in the phantom limb. Since this pioneering work was conducted in the mid-1990s, the technique has been applied to relieve\\u000a pain and enhance movement in other chronic conditions such as stroke and complex regional pain syndrome (CRPS) type 1. This\\u000a review describes how

Candida S. McCabe; Richard C. Haigh; David R. Blake

2008-01-01

94

Quasi-analytical treatment of spatially averaged radiation transfer in complex terrain  

NASA Astrophysics Data System (ADS)

We provide a new quasi-analytical method to compute the subgrid topographic influences on the shortwave radiation fluxes and the effective albedo in complex terrain as required for large-scale meteorological, land surface, or climate models. We investigate radiative transfer in complex terrain via the radiosity equation on isotropic Gaussian random fields. Under controlled approximations we derive expressions for domain-averaged fluxes of direct, diffuse, and terrain radiation and the sky view factor. Domain-averaged quantities can be related to a type of level-crossing probability of the random field, which is approximated by long-standing results developed for acoustic scattering at ocean boundaries. This allows us to express all nonlocal horizon effects in terms of a local terrain parameter, namely, the mean-square slope. Emerging integrals are computed numerically, and fit formulas are given for practical purposes. As an implication of our approach, we provide an expression for the effective albedo of complex terrain in terms of the Sun elevation angle, mean-square slope, the area-averaged surface albedo, and the ratio of atmospheric direct beam to diffuse radiation. For demonstration we compute the decrease of the effective albedo relative to the area-averaged albedo in Switzerland for idealized snow-covered and clear-sky conditions at noon in winter. We find an average decrease of 5.8% and spatial patterns which originate from characteristics of the underlying relief. Limitations and possible generalizations of the method are discussed.

LöWe, H.; Helbig, N.

2012-10-01

95

Complex estimation of bending elasticity of hemp woven fabric after washing treatment  

Microsoft Academic Search

Purpose – This paper aims to investigate the elasticity of hemp woven fabric under action of bending force, before and after washing treatment. Design\\/methodology\\/approach – Bending elasticity was monitored in three different ways: through the value of bending modulus, on the basis of fabric's resistance to creasing expressed through the value of quality number, and through the value of bending

T. V. Mihailovic

2006-01-01

96

Semantic complexity in treatment of naming deficits in aphasia: Evidence from well-defined categories  

PubMed Central

Purpose Our previous work on manipulating typicality of category exemplars during treatment of naming deficits has shown that training atypical examples generalizes to untrained typical examples but not vice versa. In contrast to natural categories that consist of fuzzy boundaries, well-defined categories (e.g., shapes) have rigid category boundaries. Whether these categories illustrate typicality effects similar to natural categories is under debate. The present study addressed this question in the context of treatment for naming deficits in aphasia. Methods Using a single subject experiment design, three participants with aphasia received a semantic feature treatment to improve naming of either typical or atypical items of shapes, while generalization was tested to untrained items of the category. Results For two of the three participants, training naming of atypical examples of shapes resulted in improved naming of untrained typical examples. Training typical examples in one participant did not improve naming of atypical examples. All three participants, however, showed weak acquisition trends. Conclusions Results of the present study show equivocal support for manipulating typicality as a treatment variable within well defined categories. Instead, these results indicate that acquisition and generalization effects within well defined categories such as shapes are overshadowed by their inherent abstractness. PMID:18845698

Kiran, Swathi; Johnson, Lauren

2009-01-01

97

Simple and Complex Post-Traumatic Stress Disorder: Strategies for Comprehensive Treatment in Clinical Practice.  

ERIC Educational Resources Information Center

This book delivers state-of-the-art techniques and information for practitioners to help individuals, groups, families, and communities suffering from post-traumatic stress disorder (PTSD). It addresses concerns about the efficacy of critical incident stress debriefing, examines the value of a variety of innovative treatment methods, and explores…

Williams, Mary Beth; Sommer, John F., Jr.

98

Sodium ferric gluconate complex in the treatment ofiron deficiency for patients on dialysis  

Microsoft Academic Search

Intravenous iron has been found to be an important adjunctive therapy in the treatment of anemia for patients ondialysis. In the United States, iron dextran had been the only form available for parenteral use until 1999. This agent has been associated with a concerning number of severe adverse reactions, in some cases resulting In patients' deaths. Recently, a form of

Steven Fishbane; John Wagner

2001-01-01

99

Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution  

PubMed Central

Aim To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment. Methods Ultra-deep pyrosequencing of HBV preCore/Core regions in 30 sequential samples (baseline [diagnosis], treatment-free, and treatment-nonresponse) from 10 retrospectively selected patients grouped according to HBeAg status over time: HBeAg+ (N?=?4), HBeAg- (N?=?2), and fluctuating HBeAg (transient seroreversion/seroconversion pattern) (N?=?4). QA complexity was defined by Shannon entropy, mutation frequency, nucleotide diversity, and mutation frequency of amino acids (MfAA) in preCore and Core. Results The QA was less complex in HBeAg+ than in HBeAg- or fluctuating HBeAg. High complexity in preCore was associated with decreased viral replication (preCore MfAA negatively correlated with HBV-DNA, p?=?0.005). QA complexity in the treatment-free period negatively correlated with values seen during treatment. Specific variants were mainly selected in the Core region in HBeAg- and fluctuating HBeAg patients, suggesting higher immune pressure than in HBeAg+. Conclusions The negative correlation between QA natural evolution and on-treatment evolution indicates the importance of pre-treatment QA study to predict QA changes in NUC nonresponders. Study of QA complexity could be useful for managing HBV infection. PMID:25393280

Homs, Maria; Caballero, Andrea; Gregori, Josep; Tabernero, David; Quer, Josep; Nieto, Leonardo; Esteban, Rafael; Buti, Maria; Rodriguez-Frias, Francisco

2014-01-01

100

Critical Drug Interactions With Agents Used for Prophylaxis and Treatment of Mycobacterium avium Complex Infections  

Microsoft Academic Search

Drug interactions occur through drug-induced hepatic enzyme induction or inhibition, or alterations in drug absorption or renal elimination. Three gene families of the cytochrome P-450 enzyme system, CYP1, CYP2, and CYP3, and five cytochrome P-450 isozymes, CYP 1A2, 2C9, 2D6, 2E1, and 3A4, are involved with the most frequently recognized drug interactions for agents used in the treatment of HIV

1997-01-01

101

Optimizing Treatment for Complex Cases of Childhood Obsessive Compulsive Disorder: A Preliminary Trial  

PubMed Central

Objective Family factors such as conflict, blame, and poor cohesion have been found to attenuate response to cognitive behavior therapy (CBT) for pediatric obsessive compulsive disorder (OCD). This study examined the feasibility and acceptability of a brief, personalized intervention for cases of pediatric OCD complicated by these family features. Method Twenty youth with a primary DSM-IV diagnosis of OCD (mean age = 12.50 years; 55% male; 60% Caucasian) and their families participated. To be included in the study, families were required to evidence poor functioning on measures of blame, conflict, and/or cohesion. Eligible families were randomly assigned to either standard treatment (ST) with 12 weeks of individual child CBT that included weekly parent check ins and psychoeducation or to Positive Family Interaction Therapy (PFIT), which consisted of 12 weeks of individual child CBT plus an additional six sessions of family treatment aimed at shifting family dynamics. Clinical outcomes were determined by blind independent evaluators using the Clinician's Global Impressions-Improvement (CGI-I) scale. Results All families completed the study. High levels of satisfaction were reported among participants in both arms of the study, despite the added burden of attending the PFIT sessions. Both mothers and fathers attended 95% of the PFIT family sessions. Families in the ST condition demonstrated a 40% response rate on the CGI-I; families in the PFIT condition demonstrated a 70% response rate. Treatment gains were maintained in both conditions at 3-month follow-up. Conclusions Preliminary data suggest that PFIT is acceptable and feasible. Further testing and treatment development are needed to optimize outcomes for complicated cases of pediatric OCD. PMID:22548378

Peris, Tara S.; Piacentini, John

2012-01-01

102

[Use of L-DOPA in the complex treatment of severe craniocerebral injuries].  

PubMed

The article is based on an analysis of the results of clinicobiochemical study of 15 patients with severe craniocerebral trauma (SCCT) whose intensive multiple-modality treatment included the use of L-DOPA. All the patients presented with direct traumatic lesions of the subcortical structures attended by diminished excretion of dopamine and DOPA. A favourable clinical effect was related to the use of DOPA which indicates that it is advisable that the drug be included into the combined therapy of severe injury to the brain attended by dysfunction of the subcortical formations. PMID:3113140

Piasetskaia, M V; Bragina, N N; Il'icheva, R F; Potapov, A A

1987-01-01

103

New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.  

PubMed

An improved understanding of the genomics of ovarian cancer and the separation of ovarian cancer into histologically and molecularly defined subgroups have affected drug development and clinical trial design in ovarian cancer. Active therapies that have been tested in ovarian cancer include agents that inhibit angiogenesis and poly (ADP-ribose) polymerase inhibitors (PARPi). However, no FDA drug approvals for ovarian cancer have been granted since 2006, and overall survival improvements have been difficult to achieve with new agents. The genomic complexity of ovarian cancer and modest single-agent activity of many biologic agents in this disease have led to testing of biologic agent combinations. In this article, we review recent advances in the understanding of the molecular diversity of ovarian cancer as well as emerging therapeutic strategies such as new agents and biologic combinations that attempt to target multiple aberrant pathways in this cancer. Clin Cancer Res; 20(20); 5150-6. ©2014 AACR. PMID:25320365

Liu, Joyce; Matulonis, Ursula A

2014-10-15

104

Endovascular treatment of a complex bilobed left superior hypophyseal internal carotid artery aneurysm: a case illustration.  

PubMed

We report the case of a 62-year-old female who presented for stent-assistant coiling of an incidental 11-mm complex bilobed left superior hypophyseal internal carotid artery aneurysm. A microcatheter was navigated into the aneurysm and trapped by a 37-mm stent. Using three-dimensional and two-dimensional coils, the elongated aneurysm was coiled. The bigger lobe was coiled first followed by the smaller lobe. Minimal residual filling of the smaller lobe will be re-evaluated at 6-month follow up. The patient tolerated the procedure well and no complications were encountered. The video can be found here: http://youtu.be/TrXfsaICQVo . PMID:24983719

Hamade, Youssef J; El Tecle, Najib E; Zammar, Samer G; El Ahmadieh, Tarek Y; Yip, Byron K; Bendok, Bernard R

2014-07-01

105

Initial experience with transluminally placed endovascular grafts for the treatment of complex vascular lesions.  

PubMed Central

OBJECTIVES: Complex arterial occlusive, traumatic, and aneurysmal lesions may be difficult or impossible to treat successfully by standard surgical techniques when severe medical or surgical comorbidities exist. The authors describe a single center's experience over a 2 1/2-year period with 96 endovascular graft procedures performed to treat 100 arterial lesions in 92 patients. PATIENTS AND METHODS: Thirty-three patients had 36 large aortic and/or peripheral artery aneurysms, 48 had 53 multilevel limb-threatening aortoiliac and/or femoropopliteal occlusive lesions, and 11 had traumatic arterial injuries (false aneurysms and arteriovenous fistulas). Endovascular grafts were placed through remote arteriotomies under local (16[17%]), epidural (42[43%]), or general (38[40%]) anesthesia. RESULTS: Technical and clinical successes were achieved in 91% of the patients with aneurysms, 91% with occlusive lesions, and 100% with traumatic arterial lesions. These patients and grafts have been followed from 1 to 30 months (mean, 13 months). The primary and secondary patency rates at 18 months for aortoiliac occlusions were 77% and 95%, respectively. The 18-month limb salvage rate was 98%. Immediately after aortic aneurysm exclusion, a total of 6 (33%) perigraft channels were detected; 3 of these closed within 8 weeks. Endovascular stented graft procedures were associated with a 10% major and a 14% minor complication rate. The overall 30-day mortality rate for this entire series was 6%. CONCLUSIONS: This initial experience with endovascular graft repair of complex arterial lesions justifies further use and careful evaluation of this technique for major arterial reconstruction. Images Figure 1. Figure 4. Figure 5. Figure 5. Figure 6. Figure 7. Figure 8. Figure 9. Figure 11. PMID:7574926

Marin, M L; Veith, F J; Cynamon, J; Sanchez, L A; Lyon, R T; Levine, B A; Bakal, C W; Suggs, W D; Wengerter, K R; Rivers, S P

1995-01-01

106

Treatment of complex foot deformities in children with the taylor spatial frame.  

PubMed

The Taylor spatial frame is a relatively new external fixator able to correct 6-axis deformities with computer accuracy using a virtual hinge. The Taylor spatial frame has gained tremendous popularity, but its use for the correction of foot deformities is still limited. Various ring configurations and a new foot program have recently become available and allow correction of the most difficult foot deformities. This article reports the results of 13 patients (15 frames) with various foot deformities treated at our institution with 3 different Taylor spatial frame configurations (standard rings construction, miter frame, and butt frame). Treatment goals were achieved in 11 patients, while mild residual deformities persisted in 2 patients. Most complications during treatment consisted of pin tract infections. One patient had premature consolidation, which was treated with additional midtarsal osteotomy; 1 had metatarsophalangeal joint subluxation, which was fixed with tendon lengthening and pining of the joint; and 1 had talar subluxation, which was reduced with residual program correction. Based on our experience, we believe the Taylor spatial frame is a very powerful and accurate surgical modality with a relatively short learning curve for the correction for most difficult foot deformities. PMID:19226012

Eidelman, Mark; Katzman, Alexander

2008-10-01

107

Alternative Techniques for Treatment of Complex Below-the Knee Arterial Occlusions in Diabetic Patients With Critical Limb Ischemia  

SciTech Connect

The purpose of this study was to describe alternative endovascular (EV) techniques and assess their feasibility and efficacy in minimizing failure rates in limb salvage for the treatment of complex below-the knee (BTK) occlusions that could not be crossed with a conventional antegrade access. Between December 2007 and November 2010, 1,035 patients (557 male) underwent EV treatment for critical limb ischemia in our institution. In 124 (12% [83 male], mean age 68.2 {+-} 0.5 years) patients, transfemoral antegrade revascularization attempt failed, and an alternative approach was used. Follow-up was performed at 1 and 6 months. Results were compared with 56 patients treated between November 2002 and November 2007, in whom conventional technique was unsuccessful and unconventional techniques were not adopted. Technical success was achieved in 119 (96%) patients. The limb-salvage rates were 96.8% and 83% at 1- and 6-month follow-up, respectively. Sixteen (12.9%) and 33 (26.6%) patients underwent reintervention at 1- and 6-month follow-up, respectively. Transcutaneous oxygen tension increased at 1 month (44.7 {+-} 1.1 vs. 15.7 {+-} 0.8 mmHg; p < 0.001) and remained stable at follow-up. Twenty (16.1%) patients required major amputation. Thirteen (10.4%) patients died during follow-up. In our previous experience, percutaneous transluminal angioplasty failure, amputation, and death rates were 10.9, 39.2, and 23.2%, respectively. Alternative techniques allowed a significant decrease of major amputation and death rates (p = 0.0001 and p = 0.02, respectively). The use of alternative techniques seems feasible in case of a failed antegrade BTK revascularization attempt and could minimize failure rates in the treatment of complex occlusions while providing satisfying clinical success rates at 6 months.

Gandini, Roberto [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy); Uccioli, Luigi [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy); Spinelli, Alessio; Del Giudice, Costantino, E-mail: costantino.delgiudice@yahoo.it; Ros, Valerio Da; Volpi, Tommaso [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy); Meloni, Marco [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy); Simonetti, Giovanni [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)

2013-02-15

108

[Jehova's Witnesses and severe injury with impending hemorrhaging : how complex is the treatment?].  

PubMed

Hemorrhage is frequently seen during the early phases of polytrauma management and intensive care treatment of the severely injured. Traumatic coagulopathy as well as the sometimes overlooked hyperfibrinolysis may lead to further complications. Therefore, transfusion of blood products and coagulation factors is often crucial. Jehova's Witnesses reject transfusions of blood and blood products due to religious convictions. In this case report a therapeutic approach of a multiple trauma patient suffering from traumatic brain injury, blunt chest trauma and liver laceration is described, who has been treated without blood products. As one main focus, ethical as well as legal aspects are discussed. Beside therapeutic concepts, such as the administration of coagulation factors, recombinant erythropoietin and iron, ethical and legal aspects remain part of the controversial discussion. PMID:21088815

Zeckey, C; Vanin, N; Neitzke, G; Mommsen, P; Bachmann, S; Frink, M; Wilhelmi, M; Krettek, C; Hildebrand, F

2011-06-01

109

Direct access to the middle meningeal artery for embolization of complex dural arteriovenous fistula: a hybrid treatment approach.  

PubMed

Endovascular embolization has become increasingly favored over microsurgical resection for treatment of complex dural arteriovenous fistulas (DAVFs). However, endovascular treatment can be restricted by tortuous transarterial access and a transvenous approach is not always feasible. We present a Borden III DAVF treated by direct access to the middle meningeal artery (MMA) and Onyx embolization performed in a hybrid operating room-angiography suite. A middle-aged patient with pulsatile headaches was found to have left transverse sinus occlusion and DAVF with retrograde cortical venous drainage fed by multiple external carotid artery (ECA) feeders. Endovascular attempts via conventional transvenous and transarterial routes were unsuccessful, and the major MMA feeder was accessed directly after temporal craniotomy was performed under neuronavigation. Onyx embolization was performed; complete occlusion of the fistula was achieved. Three-month follow-up angiography showed no residual filling; the patient remains complication-free. A combined surgical-endovascular technique in a hybrid operating room-angiography suite can be an effective treatment for DAVFs complicated by inaccessible arterial and transvenous approaches. PMID:24903968

Lin, Ning; Brouillard, Adam M; Mokin, Maxim; Natarajan, Sabareesh K; Snyder, Kenneth V; Levy, Elad I; Siddiqui, Adnan H

2014-01-01

110

Use of the Environmental Simulation Program (ESP) to Simulate Complex Waste Treatment Processes  

SciTech Connect

The Environmental Simulation Program is a process simulator designed for aqueous based chemical processes. ESP, which is produced by OLI Systems, Inc., utilizes sophisticated activity coefficient models and predictive equations that result in the ability to simulate very complex electrolyte systems (OLI, 2002). The software comes with databanks of regressed parameters for a large number of aqueous, vapor, and solid species covering most of the elements. ESP has been used extensively at the U. S. Department of Energy Hanford Site to predict nuclear waste slurry vapor-liquid-solid equilibrium. It has and is being used to model leaching and washing of nuclear waste sludges, evaporation of nuclear waste solutions, crystallization of salts, precipitation of plutonium and other metals from waste solutions, and other processing of dilute and concentrated aqueous solutions, sludges, and slurries. The software is also used extensively to rationalize the characterization of nuclear wastes using limited data from analyses of waste samples. The OLI provided databanks suffer from a legacy interaction model that limits the accuracy when neutral solutes are important. Also, the nitrate-nitrite systems typically found in nuclear wastes are not properly parameterized in ESP databases because of the existence of sodium nitrate and nitrite ion pairs. Properties databanks for ESP have been developed at Flour Federal Services that eliminate the legacy model and provide more accurate simulation results than the OLI supplied databases for such concentrated solutions and slurries.

MacLean, G. T.; Ho, Q. T.; Berger, S. R. K.

2003-02-26

111

Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches.  

PubMed

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often precedes the development of food allergy and asthma. Recent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and systemic IgE sensitization. Atopic skin is also predisposed to colonization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex virus. Causes of this abnormal skin barrier are complex and driven by a combination of genetic, environmental, and immunologic factors. These factors likely account for the heterogeneity of AD onset and the severity and natural history of this skin disease. Recent studies suggest prevention of AD can be achieved through early interventions to protect the skin barrier. Onset of lesional AD requires effective control of local and systemic immune activation for optimal management. Early intervention might improve long-term outcomes for AD and reduce the systemic allergen sensitization that leads to associated allergic diseases in the gastrointestinal and respiratory tract. PMID:25282559

Leung, Donald Y M; Guttman-Yassky, Emma

2014-10-01

112

[Improved results of the trachea scar stenosis treatment by inclusion in the complex therapy of combined application diprospan and low-intensity infrared laser radiation].  

PubMed

The experience of treating 61 patients over the rumen of stenosis of the trachea was summarizes. To improve the results suggested inclusion complex diprospan treatment in combination with low intensity infrared laser radiation. The advantages of the proposed method of treatment of tracheal stenosis scarring are reduced severity of chronic inflammation, reducing the proliferation of granulation tissue. PMID:24501929

Israfilova, S B; Gasymov, É M

2013-09-01

113

Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment.  

PubMed Central

The SCC-25 cell line is a well-established line derived from a human squamous carcinoma of the head and neck. The capacity of this cell line for recovery from potentially lethal damage following X-ray treatment has been documented. The survival curve of stationary phase SCC-25 cells exposed to various concentrations of bleomycin is biphasic with an initial sensitive phase and a less sensitive second phase as is common for many cell lines. Stationary phase SCC-25 cells were exposed to 100 mU ml-1 of bleomycin for 1 h. The drug was removed and the cells were allowed various periods to recover from potentially lethal damage. After 24 h, the SCC-25 cells showed a recovery ratio (R/R0) of 7.0 which corresponded to an immediate survival at a drug level of 27 mU ml-1, a dose 3.7-fold less than the exposure concentration of 100 mU ml-1. Over the course of the first 4 h following bleomycin exposure, 0.5 microM CDDP was a very effective inhibitor of potentially lethal damage repair, giving a R/R0 of 1.1 or nearly complete inhibition of recovery. Between 2 and 4 h the R/R0 was 1.6-1.8 with CDDP and 4.1-5.3 without CDDP indicating appreciable inhibition of recovery. Plant (10 microM) and Plato (10 microM) produced potentially lethal damage recovery inhibition patterns very similar to that of CDDP. After 1 h the recovery ratios in the presence of Plant and Plato were 1.1-1.3. Between 2 and 4 h, Plato and Plant gave recovery ratios of 1.8-2.3 and 1.6-1.9, respectively. NIPt and Pt(terpy) were examined at both 10 microM and 25 microM for their ability to inhibit potentially lethal damage recovery after bleomycin treatment. After 1 h, NIPt gave a recovery ratio of 1.3-1.4, and after 2-4 h the recovery ratio was 1.7-2.6. Pt(terpy) gave recovery ratios of 1.3-1.6 after 1 h and 1.5-1.8 after 24 h. PMID:2436643

Holden, S. A.; Teicher, B. A.; Boeheim, K.; Weichselbaum, R. R.; Ervin, T. J.

1987-01-01

114

[PRP-therapy and regular physical load in complex treatment of patients with distal form of arterial occlusion].  

PubMed

In a structure of the cardio-vascular system diseases in Ukraine the part of chronical ischemia of the lower extremities tissues constitutes more than 20%. Due to diffuse affection of the distal parts of arterial bed it is impossible to succeed in performance of a direct" revascularization in 40% of patients. In 60-87% of such patients a severe ischemia of the lower extremities tissues occurs, causing the necessity of their high amputation performance on the hip level. The results of surgical treatment of 36 patients, suffering inoperable types of the peripheral arteries occlusion were analyzed. In 18 patients the algorithm of intraoperative ultrasound duplex scanning was applied, surgical interventions were performed using optimized procedures. As a second stage the PRP-therapy was conducted, since the second post-operative day all the patients have had performed the elaborated complex of physical exercises, directed on the shin and hip muscles strengthening. Optimization of the lower extremities indirect revascularization methods have permitted to increase the rate of the treatment positive results from 55.6 to 88.9%, to reduce the unsatisfactory results rate--from 44.4 to 11.1%. The PRP-therapy and complex of regular physical exercises conduction have promoted the VEGF content enhancement in the blood serum by 15.6%. malleolar-brachial index--by 28.9% in the patients, suffering occlusion of femoro-popliteo-tibial segment. PRP-concentrate constitutes a potent cell biological activator of the VEGF, improves metabolism and microcirculation in muscles and cells of the skin. PMID:24501965

Nikonenko, A S; Gubka, A V; Voloshin, A N

2013-10-01

115

Multidimensional treatment of stochastic solvent dynamics in photoinduced proton-coupled electron transfer processes: Sequential, concerted, and complex branching mechanisms  

NASA Astrophysics Data System (ADS)

A theoretical approach for the multidimensional treatment of photoinduced proton-coupled electron transfer (PCET) processes in solution is presented. This methodology is based on the multistate continuum theory with an arbitrary number of diabatic electronic states representing the relevant charge distributions in a general PCET system. The active electrons and transferring proton(s) are treated quantum mechanically, and the electron-proton vibronic free energy surfaces are represented as functions of multiple scalar solvent coordinates corresponding to the single electron and proton transfer reactions involved in the PCET process. A dynamical formulation of the dielectric continuum theory is used to derive a set of coupled generalized Langevin equations of motion describing the time evolution of these collective solvent coordinates. The parameters in the Langevin equations depend on the solvent properties, such as the dielectric constants, relaxation time, and molecular moment of inertia, as well as the solute properties. The dynamics of selected intramolecular nuclear coordinates, such as the proton donor-acceptor distance or a torsional angle within the PCET complex, may also be included in this formulation. A surface hopping method in conjunction with the Langevin equations of motion is used to simulate the nonadiabatic dynamics on the multidimensional electron-proton vibronic free energy surfaces following photoexcitation. This theoretical treatment enables the description of both sequential and concerted mechanisms, as well as more complex processes involving a combination of these mechanisms. The application of this methodology to a series of model systems corresponding to collinear and orthogonal PCET illustrates fundamental aspects of these different mechanisms and elucidates the significance of proton vibrational relaxation and nonequilibrium solvent dynamics.

Soudackov, Alexander V.; Hazra, Anirban; Hammes-Schiffer, Sharon

2011-10-01

116

Treatment  

Microsoft Academic Search

Few clinical issues have been more hotly contested than the treatment of ADHD, particularly the relative value of medication\\u000a versus behavioral\\/psychosocial treatments (DuPaul & Power, 2008; Toplak, Connors, Shuster, Knezevic, & Parks, 2008; Wauschbusch\\u000a & Hill, 2003). Treatment decisions are often complicated by biases reflecting media coverage of diagnostic and treatment controversies,\\u000a cultural background, previous experiences or anecdotal stories from

Stephen E. Brock; Shane R. Jimerson; Robin L. Hansen

117

Negative pressure wound therapy with Bio-Dome dressing technology in the treatment of complex wounds: a case series.  

PubMed

The treatment of complex wounds is difficult and not always effective. Various treatment options are used with varying degrees of success. Negative pressure wound therapy (NPWT) is a cost-efficient and effective way to help treat these wounds. The use of a vacuum device applies the negative pressure to the site of the wound and promotes waste removal and increases circulation and tissue formation. While various NPWT systems are currently on the market, we utilised the ConvaTec Engenex® system with Bio-DomeTM technology; however, our case study is not intended to advocate the specific use of this system, but instead focuses on the use of NPWT as a viable option for wound healing. Each of the following case study patients presented with difficult-to-heal wounds that failed traditional therapeutic approaches. Through the use of NPWT, our patients saw major wound size reductions. Each patient exhibited at least a 94% reduction in wound area, wound volume or both. PMID:24762555

Penny, H L; Spinazzola, J; Green, A; Rifkah, M; Faretta, M; Youshaw, D; Weaver, A; Zaki, P

2014-04-01

118

Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation.  

PubMed

Reactive oxygen species (ROS) scavengers have not been widely used for treatment of local inflammatory reactions such as arthritis and periodontal disease because they are rapidly eliminated from the inflamed site, which results in a low therapeutic effect. Therefore, to enhance the local retention time of ROS scavengers, we developed a redox-active injectable gel (RIG) system by using poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene]-b-poly(ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene] (PMNT-PEG-PMNT) triblock copolymer, which possesses ROS scavenging nitroxide radicals as side chains of the PMNT segment. Cationic PMNT segment in PMNT-PEG-PMNT forms polyion complexes with anionic poly(acrylic acid) (PAAc) to form a flower-like micelle (ca. 79 nm), which exhibits in situ thermo-irreversible gelation under physiological conditions. We confirmed the prolonged site-specific retention time of RIG by performing in vivo noninvasive electron spin resonance imaging and quantitative evaluation. In contrast to low-molecular-weight nitroxide radical compounds that disappeared from injection sites in less than 1h after subcutaneous injection, 40% of the RIG remained even at 3 days. We also found that RIG inhibits neutrophil infiltration and cytokine production, which leads to suppression of hyperalgesia. These findings indicate the potential of RIG as an innovative approach for treatment of local inflammation. PMID:24157475

Pua, Min Ley; Yoshitomi, Toru; Chonpathompikunlert, Pennapa; Hirayama, Aki; Nagasaki, Yukio

2013-12-28

119

An approach to using conventional brachytherapy software for clinical treatment planning of complex, Monte Carlo-based brachytherapy dose distributions  

SciTech Connect

Certain brachytherapy dose distributions, such as those for LDR prostate implants, are readily modeled by treatment planning systems (TPS) that use the superposition principle of individual seed dose distributions to calculate the total dose distribution. However, dose distributions for brachytherapy treatments using high-Z shields or having significant material heterogeneities are not currently well modeled using conventional TPS. The purpose of this study is to establish a new treatment planning technique (Tufts technique) that could be applied in some clinical situations where the conventional approach is not acceptable and dose distributions present cylindrical symmetry. Dose distributions from complex brachytherapy source configurations determined with Monte Carlo methods were used as input data. These source distributions included the 2 and 3 cm diameter Valencia skin applicators from Nucletron, 4-8 cm diameter AccuBoost peripheral breast brachytherapy applicators from Advanced Radiation Therapy, and a 16 mm COMS-based eye plaque using {sup 103}Pd, {sup 125}I, and {sup 131}Cs seeds. Radial dose functions and 2D anisotropy functions were obtained by positioning the coordinate system origin along the dose distribution cylindrical axis of symmetry. Origin:tissue distance and active length were chosen to minimize TPS interpolation errors. Dosimetry parameters were entered into the PINNACLE TPS, and dose distributions were subsequently calculated and compared to the original Monte Carlo-derived dose distributions. The new planning technique was able to reproduce brachytherapy dose distributions for all three applicator types, producing dosimetric agreement typically within 2% when compared with Monte Carlo-derived dose distributions. Agreement between Monte Carlo-derived and planned dose distributions improved as the spatial resolution of the fitted dosimetry parameters improved. For agreement within 5% throughout the clinical volume, spatial resolution of dosimetry parameter data {<=}0.1 cm was required, and the virtual brachytherapy source data set included over 5000 data points. On the other hand, the lack of consideration for applicator heterogeneity effect caused conventional dose overestimates exceeding an order of magnitude in regions of clinical interest. This approach is rationalized by the improved dose estimates. In conclusion, a new technique was developed to incorporate complex Monte Carlo-based brachytherapy dose distributions into conventional TPS. These results are generalizable to other brachytherapy source types and other TPS.

Rivard, Mark J.; Melhus, Christopher S.; Granero, Domingo; Perez-Calatayud, Jose; Ballester, Facundo [Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111 (United States); Radiation Oncology Department, Physics Section, ''La Fe'' University Hospital, Avenida Campanar 21, E-46009 Valencia (Spain); Department of Atomic, Molecular, and Nuclear Physics, University of Valencia, C/Dr. Moliner 50, E-46100 Burjassot, Spain and IFIC (University of Valencia-CSIC), C/Dr. Moliner 50, E-46100 Burjassot (Spain)

2009-06-15

120

Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.  

PubMed

Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patients with stage II-IV pressure ulcers for ? 8 weeks received 150 mg/day polaprezinc (containing 116 mg L-carnosine and 34 mg zinc) per os for a maximum of 8 weeks. We measured the severity of pressure ulcers weekly using the Pressure Ulcer Scale for Healing (PUSH) score and monitored blood biochemistry. Fourteen patients (nine men; 68.4?±?11.8 years) were enrolled. Pressure ulcer stages were II (one patient; 7 %), III (nine; 64 %), and IV (four; 29 %). The PUSH score improved significantly from 8.1 [95 % CI, 6.0-10.3] at baseline to -1.4 [-4.0 to 1.1] after 8 weeks (P?treatment of pressure ulcers and could be a candidate for their oral treatment. PMID:24691900

Sakae, Kensaku; Yanagisawa, Hiroyuki

2014-06-01

121

Outlook for the use of focused shock waves and pulsed electric fields in the complex treatment of malignant neoplasms.  

PubMed

The experimental studies the synchronous action of electric field microsecond range with amplitude within the range of 1-7 kV/sm and shock waves with pressure before 100 MPa on cells membrane permeability of the mouse's ascitic tumors in vitro have shown the intensification the efficiency of the forming the irreversible pores under synchronous action. Thereby, enabling the electric field in the compression phase of shock wave pulse which can essentially reduce the electric field intensity required for breakdown cell membrane. In usual condition at amplitude of electric field, specified above, electric breakdown membrane carries basically reversible nature. At the same time in the pressure field tension phase of shock-wave pulse reversible pores, created by electric field, can grow before sizes, under which wholeness membrane is not restored. Under simultaneous action on cellular suspension the shock wave and electric field with moderate intensity cells survival is reduced in 5 once in contrast with occuring at different time's action, and in 10 once in contrast with checking. The most sensitive to influence by under study fields are cells in phase of the syntheses DNA, preparation to fission and in phase of the mitosis. Thereby, continuation of the studies on use synchronous action shock waves and pulsed electric fields in complex treatment of the tumors introduces perspective. PMID:17946761

Garilevich, B A; Andrianov, Yu V; Olefir, Yu V; Zubkov, A D; Rotov, A E

2006-01-01

122

The use of pulsed electromagnetic fields with complex modulation in the treatment of patients with diabetic polyneuropathy.  

PubMed

Clinical and electroneuromyographic studies were performed in 121 patients with diabetic polyneuropathy (DPN) before and after courses of treatment with pulsed electromagnetic fields with complex modulation (PEMF-CM) at different frequencies (100 and 10 Hz). Testing of patients using the TSS and NIS LL scales demonstrated a correlation between the severity and frequency of the main subjective and objective effects of disease and the stage of DPN. The severity of changes in the segmental-peripheral neuromotor apparatus--decreases in muscle bioelectrical activity, the impulse conduction rate along efferent fibers of peripheral nerves, and the amplitude of the maximum M response--depended on the stage of DPN and the duration of diabetes mellitus. The earliest and most significant electroneuromyographic signs of DPN were found to be decreases in the amplitude of the H reflex and the Hmax/Mmax ratio in the muscles of the lower leg. Application of PEMF-CM facilitated regression of the main clinical symptoms of DPN, improved the conductive function of peripheral nerves, improved the state of la afferents, and improved the reflex excitability of functionally diverse motoneurons in the spinal cord. PEMF-CM at 10 Hz was found to have therapeutic efficacy, especially in the initial stages of DPN and in patients with diabetes mellitus for up to 10 years. PMID:14635988

Musaev, A V; Guseinova, S G; Imamverdieva, S S

2003-10-01

123

The effect of locally implanted complexes of adriamycin-hydroxyapatite complexes on tumor--study of a new alternative treatment for hepatic cancer.  

PubMed

A new targeting anticancer system was prepared by using hydroxyapatite particles (2 mm in diameter) as carrier material and adriamycin as anticancer agent. The adsorption and release properties of the complexes were assayed by fluorometry in vivo and in vitro and the curative effect on W-256 sarcoma of rat was observed. The results showed that one particle of hydroxyapatite could adsorb approximately 0.08 mg adriamycin and they can maintain a steady and slow release of adriamycin from hydroxyapatite for one month. When hydroxyapatite-adriamycin complexes were implanted into the liver of rat, liver adriamycin concentration at the implanted region was obviously higher than that achieved by injection of adriamycin solution. The locally implanted complexes obviously inhibited the growth of subcutaneous implanted tumor of rat, and increased the survival rate of rat with implanted liver tumor. PMID:12840899

Xia, Q; Nie, H; Chen, D; Chen, J; Tian, Y; Zhang, J

1999-01-01

124

Antiproliferative and Proapoptotic Activities of Methanolic Extracts from Ligustrum vulgare L. as an Individual Treatment and in Combination with Palladium Complex  

PubMed Central

The aim of this study is to examine the growth inhibitory effects of methanolic leaf and fruit extracts of L. vulgare on HCT-116 cells over different time periods and their synergistic effect with a Pd(apox) complex. The antiproliferative activity of plant extracts alone or in combination with the Pd(apox) complex was determined using MTT cell viability assay, where the IC50 value was used as a parameter of cytotoxicity. Results show that antiproliferative effects of L. vulgare extracts increase with extension of exposure time, with decreasing IC50 values, except for 72 h where the IC50 values for methanolic leaf extract were lower than for the fruit extract. The Pd(apox) complex alone had a weak antiproliferative effect, but combination with L. vulgare extracts caused stronger effects with lower IC50 values than with L. vulgare extracts alone. The type of cell death was explored by fluorescence microscopy using the acridin orange/ethidium bromide method. Treatments with plant extracts caused typical apoptotic morphological changes in HCT-116 cells and co-treatments with Pd(apox) complex caused higher levels of apoptotic cells than treatment with plant extracts alone. The results indicate that L. vulgare is a considerable source of natural bioactive substances with antiproliferative activity on HCT-116 cells and which have a substantial synergistic effect with the Pd(apox) complex. PMID:22408469

Curcic, Milena G.; Stankovic, Milan S.; Mrkalic, Emina M.; Matovic, Zoran D.; Bankovic, Dragic D.; Cvetkovic, Danijela M.; ?acic, Dragana S.; Markovic, Snezana D.

2012-01-01

125

Comparing Two Service Delivery Models for Homeless Individuals With Complex Behavioral Health Needs: Preliminary Data From Two SAMHSA Treatment for Homeless Studies  

Microsoft Academic Search

Assertive Community Treatment (ACT) and the Comprehensive, Continuous, Integrated System of Care (CCISC) are two models for delivering services to homeless persons with complex behavioral health needs. This quasi-experimental study presents preliminary data comparing these two programs. The first program was based out of a community mental health center and utilized the ACT model of care with supported housing (ACT-SH),

M. Scott Young; Colleen Clark; Kathleen Moore; Blake Barrett

2009-01-01

126

[Experience of using phytopreparation Alba (root extract of the Potentilla alba) in complex treatment of thyroid pathology in children and adolescents].  

PubMed

This article presents the background for including phytopreparation Alba (root extract of the Potentilla alba) into complex treatment of thyroid pathology. The findings confirm visible reduction of size of the thyroid gland and normalizing its functions in children and adults with the thyroid gland with normal or enhanced function treated by Alba per oral. PMID:25286612

Turchaninova, L I

2014-01-01

127

Technology Evaluation for the Big Spring Water Treatment System at the Y-12 National Security Complex, Oak Ridge, Tennessee  

Microsoft Academic Search

The Y-12 National Security Complex (Y-12 Complex) is an active manufacturing and developmental engineering facility that is located on the U.S. Department of Energy (DOE) Oak Ridge Reservation. Building 9201-2 was one of the first process buildings constructed at the Y-12 Complex. Construction involved relocating and straightening of the Upper East Fork Poplar Creek (UEFPC) channel, adding large quantities of

2002-01-01

128

www.Moonviewsanctuary.com Complex Multimodality Treatment of an Alcoholic Client Following the Moonview Model: Creating Synergistic Effects by Integrating Different Treatment Approaches  

Microsoft Academic Search

This case study examines intensive outpatient treatment of a 42 - year old man suffering from multiple mental and physical complaints who is abusing alcohol, presumably to self - medicate emotion al distress. The idiographic (individual - centered) study protocol employed the Moonview Model , a customized multidisciplinary treatment strategy, to reduce the client's substance abuse and emotional distress while

Stephen Sideroff; Terry Eagan; Gaetano Vaccaro

129

The sweet spot of forward osmosis: Treatment of produced water, drilling wastewater, and other complex and difficult liquid streams  

E-print Network

The sweet spot of forward osmosis: Treatment of produced water, drilling wastewater, and other treated by forward osmosis. · Forward osmosis treatment of drilling mud and produced water was evaluated November 2013 Accepted 6 November 2013 Available online xxxx Keywords: Forward osmosis Wastewater treatment

130

PLGA Microparticles Encapsulating Prostaglandin E 1 -Hydroxypropyl-?-cyclodextrin (PGE 1 -HP?CD) Complex for the Treatment of Pulmonary Arterial Hypertension (PAH)  

Microsoft Academic Search

Purpose  To test the efficacy and viability of poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating an inclusion complex of prostaglandin E1 (PGE1) and 2-hydroxypropyl-?-cyclodextrin (HP?CD) for pulmonary delivery of PGE1 for treatment of pulmonary arterial hypertension (PAH), a disease of pulmonary circulation.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  PLGA-based microparticulate formulations of PGE1-HP?CD inclusion complex or plain PGE1 were prepared by a double-emulsion solvent evaporation method. HP?CD was

Vivek Gupta; Marauo Davis; Fakhrul Ahsan

2011-01-01

131

Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals  

PubMed Central

Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment. Coadministration of NNRTIs and PIs with AL could potentially cause complex pharmacokinetic drug interactions. NNRTI by inducing CYP450 3A4 enzyme and PIs by inhibiting CYP450 3A4 enzymes could influence both artemether and lumefantrine concentrations and their active metabolites dihydroartemisinin and desbutyl-lumefantrine, predisposing patients to poor treatment response, toxicity, and risk for development of resistance. There are scanty data on these interactions and their consequences. Pharmacokinetic studies to evaluate these interactions in the target populations are urgently needed. PMID:22312573

Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Khoo, Saye; Merry, Concepta; Van geertruyden, Jean-Pierre

2011-01-01

132

Chronic benzodiazepine agonist treatment produces functional uncoupling of the gamma-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons.  

PubMed

We have investigated the effect of chronic flurazepam HCl treatment on the gamma-aminobutyric acid (GABA)A receptor complex in cultured mammalian cortical neurons. Chronic flurazepam (1-5 microM, for 1-10 days) treatment did not produce any changes in the morphological appearance or the cell protein content of cortical neurons. The basal binding of [3H]flunitrazepam, [3H] Ro15-1788, and [3H]Ro15-4513 was also not altered after the chronic treatment. However, chronic flurazepam treatment produced uncoupling between GABA and pentobarbital sites and the [3H]flunitrazepam binding site. The EC50 values of GABA and pentobarbital were not significantly altered after chronic flurazepam treatment; however, their Emax values were decreased by approximately 50%. The effect of chronic flurazepam treatment on the observed uncoupling was both time and concentration dependent. Furthermore, the binding of [3H]GABA and t-butylbicyclophosphoro[35S]thionate was also not altered by chronic flurazepam treatment. The effect of GABA on 36Cl influx was not altered after chronic flurazepam treatment; however, treatment significantly attenuated the ability of diazepam to enhance GABA-induced 36Cl influx. Chronic flurazepam-induced uncoupling and decreased diazepam efficacy were reversed by the concomitant presence of the benzodiazepine antagonist Ro15-1788, suggesting that these events are mediated via the benzodiazepine receptor site. Taken together, these results suggest that chronic benzodiazepine treatment produces uncoupling of GABA and pentobarbital sites from the benzodiazepine site and decreased coupling between the benzodiazepine site and GABA receptor-gated Cl- channels. The uncoupling and decreased efficacy may be due to an alteration in the levels of various alpha subunits and may be responsible for the tolerance associated with chronic benzodiazepine agonist treatment. PMID:8183240

Hu, X J; Ticku, M K

1994-04-01

133

TEST: A Z, A&Z, A  

PubMed Central

Background Soft tissue injuries associated with distal radius fractures have been reported by some authors. Arthroscopy can be used to evaluate the condition of the articular surface and intracarpal soft tissues and as an aid to treatment. There are three intracarpal soft tissues of particular importance: the triangular fibrocartilage complex (TFCC), the scapholunate interosseous ligament (SLIL), and the lunotriquetral interosseous ligament (LTIL). The purpose of this study was to evaluate intracarpal soft tissue injuries and their relationships with fracture types during arthroscopic surgical treatment of distal radius fractures. Methods Eighty-nine patients in our hospital underwent surgical treatment by arthroscopy for a fracture of the distal end of the radius. They ranged in age from 17 to 92 years (mean, 62.2 years), and comprised 20 men (mean age, 45.6 years) and 69 women (mean age, 66.5 years). The AO classification data on plain radiographs indicated A2 fracture in four patients, A3 fracture in 10 patients, C1 fracture in two patients, C2 fracture in 24 patients, and C3 fracture in 49 patients. Wrist arthroscopy was performed with vertical traction, and intracarpal soft tissues were examined. For assessment of the TFCC in the radiocarpal space, the Palmar classification was used. For assessment of the SLIL and LTIL in the midcarpal space, the Geissler classification was used. Results TFCC injury was present in 59% of cases, SLIL injury in 54.5% of cases, and LTIL injury in 34.5% of cases. Only 17.1% of patients (14/82 patients) were negative for all three types of injury. In 81% of cases (72/89 patients), some intracarpal soft tissue injury was present in association with the fracture. Conclusions The fracture was complicated by TFCC injury in 59% of patients, SLIL injury in 54.5% of patients, and LTIL injury in 34.5% of patients, irrespective of the fracture type. PMID:24004506

2013-01-01

134

Carbonic Anhydrase Inhibitors. Part 91. Metal Complexes of Heterocyclic Sulfonamides as Potential Pharmacological Agents in the Treatment of Gastric Acid Secretion Imbalances  

PubMed Central

Zinc, magnesium, aluminum and copper complexes of several potent, clinically used carbonic anhydrase (CA) sulfonamide inhibitors, such as acetazolamide, methazolamide, ethoxzolamide and benzolamide were tested for their possible applications as antacids, in experimental animals. Gastric acid secretion parameters 3 days after treatment with these CA inhibitors (2 × 500 mg, twice a day), in dogs with chronic gastric fistulas, led to the observation that the gastric acid parameters BAO (the basal acid output), and MAO (the maximal acid output after stimulation with histamine) were drastically reduced, as compared to the same parameters in animals that did not receive these enzyme inhibitors. These are promising results for the possible use of metal complexes of heterocyclic sulfonamides as treatment alternatives (alone or in combination with other drugs) for gastric acid secretion imbalances. PMID:18475926

Ilies, Marc A.; Scozzafava, Andrea

2000-01-01

135

Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study  

SciTech Connect

Brain glucose metabolism was evaluated in four patients with acquired immunodeficiency syndrome (AIDS) dementia complex using (/sup 18/F)fluorodeoxyglucose (FDG) and positron emission tomography (PET) scans at the beginning of therapy with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine), and later in the course of therapy. In two patients, baseline, large focal cortical abnormalities of glucose utilization were reversed during the course of therapy. In the other two patients, the initial PET study did not reveal pronounced focal alterations, while the post-treatment scans showed markedly increased cortical glucose metabolism. The improved cortical glucose utilization was accompanied in all patients by immunologic and neurologic improvement. PET-FDG studies can detect cortical metabolic abnormalities associated with AIDS dementia complex, and may be used to monitor the metabolic improvement in response to AZT treatment.

Brunetti, A.; Berg, G.; Di Chiro, G.; Cohen, R.M.; Yarchoan, R.; Pizzo, P.A.; Broder, S.; Eddy, J.; Fulham, M.J.; Finn, R.D.

1989-05-01

136

CARBONIC ANHYDRASE INHIBITORS. PART 91. METAL COMPLEXES OF HETEROCYCLIC SULFONAMIDES AS POTENTIAL PHARMACOLOGICAL AGENTS IN THE TREATMENT OF GASTRIC ACID SECRETION IMBALANCES  

E-print Network

Abstract: Zinc, magnesium, aluminum and copper complexes of several potent, clinically used carbonic anhydrase (CA) sulfonamide inhibitors, such as acetazolamide, methazolamide, ethoxzolamide and benzolamide were tested for their possible applications as antacids, in experimental animals. Gastric acid secretion parameters 3 days after treatment with these CA inhibitors (2 x 500 mg, twice a day), in dogs with chronic gastric fistulas, led to the observation that the gastric acid parameters BAO (the basal acid output), and MAO (the maximal acid output after stimulation with histamine) were drastically reduced, as compared to the same parameters in animals that did not receive these enzyme inhibitors. These are promising results for the possible use of metal complexes of heterocyclic sulfonamides as treatment alternatives (alone or in combination with other drugs) for gastric acid secretion imbalances.

Marc A. Ilies; Claudiu T. Supuran; Andrea Scozzafava

137

THE JOURNAL OF CHEMICAL PHYSICS 135, 094304 (2011) "Adiabatic-hindered-rotor" treatment of the parahydrogen-water complex  

E-print Network

for parahydrogen pH2 in CO2­H2 complexes [H. Li, P.-N. Roy, and R. J. Le Roy, J. Chem. Phys. 133, 104305 (2010); H of the parahydrogen-water complex Tao Zeng,1 Hui Li,2 Robert J. Le Roy,1 and Pierre-Nicholas Roy1,a) 1 Department. Li, R. J. Le Roy, P.-N. Roy, and A. R. W. McKellar, Phys. Rev. Lett. 105, 133401 (2010)], we apply

Le Roy, Robert J.

138

Surgical treatment of complex tibial plateau fractures by closed reduction and external fixation. A review of 32 consecutive cases operated  

Microsoft Academic Search

Complex tibial plateau fractures are a challenge in trauma surgery. In these fractures it is necessary to anatomically reduce\\u000a the articular part of the fracture and to obtain stable fixation. The aim of this study is to review the results of a surgical\\u000a technique consisting of fluoroscopic closed reduction and combined percutaneous internal and external fixation. Thirty-two\\u000a complex tibial plateau

C. Faldini; M. Manca; S. Pagkrati; D. Leonetti; M. Nanni; G. Grandi; M. Romagnoli; M. Himmelmann

2005-01-01

139

The effect of multileaf collimator leaf width on the radiosurgery planning for spine lesion treatment in terms of the modulated techniques and target complexity  

PubMed Central

Purpose We aim to evaluate the effects of multileaf collimator (MLC) leaf width (5 mm vs. 2.5 mm) on the radiosurgery planning for the treatment of spine lesions according to the modulated techniques (intensity-modulated radiotherapy [IMRT] vs. volumetric-modulated arc therapy [VMAT]) and the complexity of the target shape. Methods For this study, artificial spinal lesions were contoured and used for treatment plans. Three spinal levels (C5, T5, and L2 spines) were selected, and four types of target shapes reflecting the complexity of lesions were contoured. The treatment plans were performed using 2.5-mm and 5-mm MLCs, and also using both static IMRT and VMAT. In total, 48 treatment plans were established. The efficacy of each treatment plan was compared using target volume coverage (TVC), conformity index (CI), dose gradient index (GI), and V30%. Results When the 5-mm MLC was replaced by the 2.5-mm MLC, TVC and GI improved significantly by 5.68% and 6.25%, respectively, while CI did not improve. With a smaller MLC leaf width, the improvement ratios of the TVC were larger in IMRT than VMAT (8.38% vs. 2.97%). In addition, the TVC was improved by 14.42-16.74% in target type 4 compared to the other target types. These improvements were larger in IMRT than in VMAT (27.99% vs. 6.34%). The V30% was not statistically different between IMRT and VMAT according to the MLC leaf widths and the types of target. Conclusion The smaller MLC leaf width provided improved target coverage in both IMRT and VMAT, and its improvement was larger in IMRT than in VMAT. In addition, the smaller MLC leaf width was more effective for complex-shaped targets. PMID:24606890

2014-01-01

140

EVALUATION OF INTENSITY MODULATED RADIATION THERAPY (IMRT) DELIVERY ERROR DUE TO IMRT TREATMENT PLAN COMPLEXITY AND IMPROPERLY MATCHED DOSIMETRY DATA  

Microsoft Academic Search

Intensity modulated radiation therapy (IMRT) is a technique that delivers a highly conformal dose distribution to a target volume while attempting to maximally spare the surrounding normal tissues. IMRT is a common treatment modality used for treating head and neck (H&N) cancers, and the presence of many critical structures in this region requires accurate treatment delivery. The Radiological Physics Center

Jacqueline R Tonigan

2011-01-01

141

Analysis of lignin-carbohydrate and lignin-lignin linkages after hydrolase treatment of xylan-lignin, glucomannan-lignin and glucan-lignin complexes from spruce wood.  

PubMed

Xylan-lignin (XL), glucomannan-lignin (GML) and glucan-lignin (GL) complexes were isolated from spruce wood, hydrolyzed with xylanase or endoglucanase/?-glucosidase, and analyzed by analytical pyrolysis and 2D-NMR. The enzymatic hydrolysis removed most of the polysaccharide moieties in the complexes, and the lignin content and relative abundance of lignin-carbohydrate linkages increased. Analytical pyrolysis confirmed the action of the enzymatic hydrolysis, with strong decreases of levoglucosane and other carbohydrate-derived products. Unexpectedly it also revealed that the hydrolase treatment alters the pattern of lignin breakdown products, resulting in higher amounts of coniferyl alcohol. From the anomeric carbohydrate signals in the 2D-NMR spectra, phenyl glycoside linkages (undetectable in the original complexes) could be identified in the hydrolyzed GML complex. Lower amounts of glucuronosyl and benzyl ether linkages were also observed after the hydrolysis. From the 2D-NMR spectra of the hydrolyzed complexes, it was concluded that the lignin in GML is less condensed than in XL due to its higher content in ?-O-4' ether substructures (62 % of side chains in GML vs 53 % in XL) accompanied by more coniferyl alcohol end units (16 vs 13 %). In contrast, the XL lignin has more pinoresinols (11 vs 6 %) and dibenzodioxocins (9 vs 2 %) than the GML (and both have ~13 % phenylcoumarans and 1 % spirodienones). Direct 2D-NMR analysis of the hydrolyzed GL complex was not possible due to its low solubility. However, after sample acetylation, an even less condensed lignin than in the GML complex was found (with up to 72 % ?-O-4' substructures and only 1 % pinoresinols). The study provides evidence for the existence of structurally different lignins associated to hemicelluloses (xylan and glucomannan) and cellulose in spruce wood and, at the same time, offers information on some of the chemical linkages between the above polymers. PMID:24531838

Du, Xueyu; Pérez-Boada, Marta; Fernández, Carmen; Rencoret, Jorge; del Río, José C; Jiménez-Barbero, Jesús; Li, Jiebing; Gutiérrez, Ana; Martínez, Angel T

2014-05-01

142

Fenbendazole Treatment Without Environmental Decontamination Eradicates Syphacia muris From All Rats in a Large, Complex Research Institution  

Microsoft Academic Search

Syphacia muris parasitism was eliminated from rats and voles by feeding fenbendazole-medicated chow (150 ppm) for five 7-day periods; treatment periods were separated by 7-day periods of feeding non-medicated chow, yielding atotal treatment course of 9 weeks. No other manipulations to facilitate eradication, including the use of filter tops, autoclaved cages, environmen- tal decontamination, colony depopulation, breeding cessation, and research

MICHAEL J. HUERKAMP; KIMBERLEY A. BENJAMIN; LOIS A. ZITZOW; JENNIFER K. PULLIUM; JENNIFER A. LLOYD; WESLEY D. THOMPSON; SONJI K. WEBB

2000-01-01

143

Functional outcome of arthroscopic assisted fixation of distal radius fractures  

PubMed Central

Background: Many studies in literature have supported the role of wrist arthroscopy as an adjunct to the stable fixation of unstable intraarticular distal radial fractures. This article focuses on the surgical technique, indications, advantages, and results using wrist arthroscopy to assess articular reduction and evaluates the treatment of carpal ligament injuries and triangular fibrocartilage complex (TFCC) injuries in conjunction with the stable fixation of distal radial fractures. Materials and Methods: We retrospectively evaluated 27 patients (16 males and 11 females), who underwent stable fixation of intraarticular distal radial fractures with arthroscopic evaluation of the articular reduction and repair of associated carpal injuries. As per the AO classification, they were 9 C 1, 12 C2, 2 C3, 3 B 1, and 1 B2 fractures. The final results were evaluated by modified Mayo wrist scoring system. The average age was 41 years (range: 18-68 years). The average followup was of 26 months (range 24-52 months). Results: Five patients needed modification of the reduction and fixation after arthroscopic joint evaluation. Associated ligament lesions found during the wrist arthroscopy were TFCC tears (n=17), scapholunate ligament injury (n=8), and luno-triquetral ligament injury (n=1). Five patients had combined injuries i.e. included TFCC tear, scapholunate and/or lunotriquetral ligament tear. There were 20 excellent, 3 good, and 4 fair results using this score. Conclusion: The radiocarpal and mid carpal arthroscopy is a useful adjunct to stable fixation of distal radial fractures. PMID:23798761

Khanchandani, Prakash; Badia, Alejandro

2013-01-01

144

Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: A double-blind placebo controlled study  

Microsoft Academic Search

Complex regional pain syndrome (CRPS) is a severe chronic pain condition that most often develops following trauma. The pathophysiology of CRPS is not known but both clinical and experimental evidence demonstrate the important of the NMDA receptor and glial activation in its induction and maintenance. Ketamine is the most potent clinically available safe NMDA antagonist that has a well established

Robert J. Schwartzman; Guillermo M. Alexander; John R. Grothusen; Terry Paylor; Erin Reichenberger; Marielle Perreault

2009-01-01

145

Successful treatment of chylous ascites secondary to Mycobacterium avium complex in a patient with the acquired immune deficiency syndrome  

Microsoft Academic Search

Chylous ascites is a rare form of ascites, the presence of which generally denotes a very poor long term prognosis. We report the case of a patient with acquired immune deficiency syndrome (AIDS) and massive chylous ascites secondary to Mycobacterium avium complex (MAC) infection, identified in the ascitic fluid by a DNA probe assay. With multidrug anti-MAC therapy the ascites

Andrew P Keaveny; Michael S Karasik; Harrison W Farber

1999-01-01

146

A complete mass balance of a complex combined anaerobic/aerobic municipal source-separated waste treatment plant.  

PubMed

In this study a combined anaerobic/aerobic full-scale treatment plant designed for the treatment of the source-separated organic fraction of municipal solid waste (OFMSW) was monitored over a period of one year. During this period, full information was collected about the waste input material, the biogas production, the main rejects and the compost characteristics. The plant includes mechanical pre-treatment, dry thermophilic anaerobic digestion, tunnel composting system and a curing phase to produce compost. To perform the monitoring of the entire plant and the individual steps, traditional chemical methods were used but they present important limitations in determining the critical points and the efficiency of the stabilization of the organic matter. Respiration indices (dynamic and cumulative) allowed for the quantitative calculation of the efficiency of each treatment unit. The mass balance was calculated and expressed in terms of Mgy(-1) of wet (total) matter, carbon, nitrogen and phosphorus. Results show that during the pre-treatment step about 32% of the initial wet matter is rejected without any treatment. This also reduces the biodegradability of the organic matter that continues to the treatment process. About 50% of the initial nitrogen and 86.4% of the initial phosphorus are found in the final compost. The final compost also achieves a high level of stabilization with a dynamic respiration index of 0.3±0.1g O(2) per kg of total solids per hour, which implies a reduction of 93% from that of the raw OFMSW, without considering the losses of biodegradable organic matter in the refuse (32% of the total input). The anaerobic digestion process is the main contributor to this stabilization. PMID:22261421

Pognani, Michele; Barrena, Raquel; Font, Xavier; Sánchez, Antoni

2012-05-01

147

Effective tumor treatment by VEGF siRNA complexed with hydrophobic poly(amino acid)-modified polyethylenimine.  

PubMed

Two copolymers are designed and synthesised for siRNA delivery based on polyethylenimine by grafting hydrophilic acrylamide segments and hydrophobic poly(?-benzyl L-glutamate). The amphiphilic PEI-PBLG/siRNA complex demonstrates high gene silencing efficiency in the absence or presence of 10?vol% and 50?vol% sera in vitro. The anti-tumor effects in vivo are evaluated in luciferase-bearing mice expressing CT26 tumors. PEI-PBLG/siVEGF complex provides a higher and more sustained suppressive effect by reducing VEGF mRNA expression in the tumors, leading to higher tumor growth inhibition efficacy. Further studies on the potential use of the PEI-PBLG carrier system in mediating the silencing of genes other than VEGF or in other tumor models are recommended. PMID:23873676

Chen, Jie; Tian, Huayu; Dong, Xuan; Guo, Zhaopei; Jiao, Zixue; Li, Feifan; Kano, Arihiro; Maruyama, Atsushi; Chen, Xuesi

2013-10-01

148

Chemical and biological profiles of novel copper(II) complexes containing S-donor ligands for the treatment of cancer.  

PubMed

In the last years, we have synthesized some new platinum(II), palladium(II), gold(I/III) complexes with dithiocarbamato derivatives as potential anticancer drugs, to obtain compounds with superior chemotherapeutic index in terms of increased bioavailability, higher cytotoxicity, and lower side effects than cisplatin. On the basis of the obtained encouraging results, we have been studying the interaction of CuCl2 with methyl-/ethyl-/tert-butylsarcosine-dithiocarbamato moieties in a 1:2 molar ratio; we also synthesized and studied the N,N-dimethyl- and pyrrolidine-dithiocarbamato copper complexes for comparison purposes. The reported compounds have been successfully isolated, purified, and fully characterized by means of several spectroscopic techniques. Moreover, the electrochemical properties of the designed compounds have been studied through cyclic voltammetry. In addition, the behavior in solution was followed by means of UV-vis technique to check the stability with time in physiological conditions. To evaluate their in vitro cytotoxic properties, preliminary biological assays (MTT test) have been carried out on a panel of human tumor cell lines. The results show that cytotoxicity levels of all of the tested complexes are comparable or even greater than that of the reference drug (cisplatin). PMID:18572881

Giovagnini, Lorena; Sitran, Sergio; Montopoli, Monica; Caparrotta, Laura; Corsini, Maddalena; Rosani, Claudia; Zanello, Piero; Dou, Q Ping; Fregona, Dolores

2008-07-21

149

Delamination technique together with longitudinal incisions for treatment of Chiari I\\/syringomyelia complex: a prospective clinical study  

Microsoft Academic Search

BACKGROUND: Treatment modalities in Chiari malformation type 1(CMI) accompanied by syringomyelia have not yet been standardized. Pathologies such as a small posterior fossa and thickened dura mater have been discussed previously. Various techniques have been explored to enlarge the foramen magnum and to expand the dura. The aim of this clinical study was to explore a new technique of excision

Kadir Kotil; Tu?rul Ton; Rabia Tari; Yildiray Savas

2009-01-01

150

Sclerotherapy with 5% tetracycline is a simple alternative to potentially complex surgical treatment of ovarian endometriomas before in vitro fertilization  

Microsoft Academic Search

ObjectiveConventional treatment of endometriosis involves drainage and removal of the cyst wall, which often results in inadvertent resection of normal ovarian tissue. We previously reported that 12 patients were successfully treated with sclerotherapy using 5% tetracycline. We now report our experience with sclerotherapy before in vitro fertilization (IVF) in an additional 20 patients with ovarian endometriomas.

Jeffrey D Fisch; Geoffrey Sher

2004-01-01

151

The Role of Semantic Complexity in Treatment of Naming Deficits: Training Semantic Categories in Fluent Aphasia by Controlling Exemplar Typicality  

Microsoft Academic Search

The effect of typicality of category exemplars on naming was investigated using a single subject experimental design across participants and behaviors in 4 patients with fluent aphasia. Participants received a semantic feature treatment to improve naming of either typical or atypical items within semantic categories, while generalization was tested to untrained items of the category. The order of typicality and

Swathi Kiran; Cynthia K. Thompson

2003-01-01

152

[New aspects of efficacy of using apparatus-programming complex "andro-gin" in the treatment of chronic prostatitis].  

PubMed

The results of usage of Andro-Gin unit in 187 patients with chronic prostatitis have shown that in most cases prostatitis is caused by bacteria. Andro-gin unit included in combined treatment of chronic prostatitis provides good results as it turns biofil bacteria into planktonic ones. PMID:17444153

Pereverzev, A S; Chepenko, A V

2006-01-01

153

A double-blind placebo-controlled study of 5-fluorouracil:cyclodextrin complex loaded thermosensitive gel for the treatment of HPV induced condyloma  

Microsoft Academic Search

Objective of this double-blind placebo-controlled study was to determine the efficacy of thermosensitive mucoadhesive gel\\u000a loaded with 5-fluorouracil (5-FU):hydroxypropyl-ß-cyclodextrin (HP-ß-CD) complex via topical administration or intralesional\\u000a injection for the treatment of human papilloma virus induced condyloma in 44 women. The diagnosis of human papilloma virus\\u000a was established with clinical, histopathological and polymerase chain reaction techniques. Subjects were randomized into four

Erem Bilensoy; Perran Moroy; Yasemin Ç?rpanl?; Tamer Bilensoy; Sema Çal??; Leyla Mollamahmutoglu

2011-01-01

154

Additive Complex Ayurvedic Treatment in Patients with Fibromyalgia Syndrome Compared to Conventional Standard Care Alone: A Nonrandomized Controlled Clinical Pilot Study (KAFA Trial)  

PubMed Central

Background. Fibromyalgia (FMS) is a challenging condition for health care systems worldwide. Only limited trial data is available for FMS for outcomes of complex treatment interventions of complementary and integrative (CIM) approaches. Methods. We conducted a controlled, nonrandomized feasibility study that compared outcomes in 21 patients treated with Ayurveda with those of 11 patients treated with a conventional approach at the end of a two-week inpatient hospital stay. Primary outcome was the impact of fibromyalgia on patients as assessed by the FIQ. Secondary outcomes included scores of pain intensity, pain perception, depression, anxiety, and quality of sleep. Follow-up assessments were done after 6 months. Results. At 2 weeks, there were comparable and significant improvements in the FIQ and for most of secondary outcomes in both groups with no significant in-between-group differences. The beneficial effects for both treatment groups were partly maintained for the main outcome and a number of secondary outcomes at the 6-month followup, again with no significant in-between-group differences. Discussion. The findings of this feasibility study suggest that Ayurvedic therapy is noninferior to conventional treatment in patients with severe FMS. Since Ayurveda was only used as add-on treatment, RCTs on Ayurveda alone are warranted to increase model validity. This trial is registered with NCT01389336. PMID:24073008

Kessler, Christian S.; Meier, Larissa; Stapelfeldt, Elmar; Schutte, Silvia; Duda, Joachim; Michalsen, Andreas

2013-01-01

155

[The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment].  

PubMed

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures. There are also meaningful supplementary therapy procedures beyond the boundaries of classical school medicine. The WHO staging scheme provides the basis for every pain therapy. For the oral therapeutic procedures in current use the following medications with differing levels of evidence have been recommended: amitriptylin, hydroxyzin, pentosan polysulfate. Many other orally administered drugs have also been used although in many cases evidence of efficacy is lacking, these included anticonvulsants, L-arginine and various immunomodulators and immunosuppressants. Among the intravesical therapeutic procedures botulinum toxin A, dimethyl sulfoxide, heparin and glycosaminoglycan substitutes have been used. For the physical procedures, besides bladder distension, hyperbaric oxygen therapy shows efficacy. When the conventional therapeutic methods fail, surgical (partial) removal of the urinary bladder or urinary diversion procedures represent the therapeutic ultimo ratio. There are hardly any controlled studies on alternative curative procedures although rather good results have been obtained in chronic pelvic pain syndrome with acupuncture as an additional therapeutic modality. PMID:18663671

Binder, I; Rossbach, G; van Ophoven, A

2008-07-01

156

[Interest in wrist arthroscopy for treatment of articular fractures of the distal radius: report of 27 cases].  

PubMed

We report our results of treatment of intra articular distal radius fracture assisted by wrist arthroscopy. Twenty six patients (15 men and 11 women) were treated using this technique. All the patients were operated on under regional anaesthesia, the elbow flexed to 90 degrees, and in-line traction applied using "Japanese" fingers traps (4 to 6 kgs). After articular cleansing, reduction under arthroscopic and fluoroscopic control was carried out using K-wires. All fractures were intra articular and in four cases of fractures with four fragments, it was necessary to combine a volar plate with the K-wires. There were 21 associated ligament injuries (seven TFCC tears, four lunotriquetral ligament injuries and ten scapholunate injuries of which four necessitated pinning). Our average follow-up time was 16 months (6-26 months). There was absence of pain in 23 cases and the results were good for wrist motion and strength. We did not experienced any severe secondary displacement. Eighteen excellent, seven good results and one average result were obtained. The quality of these functional and anatomical results seems to be directly linked to the quality of reduction obtained under arthroscopy and the quality of internal fixation carried out under traction. PMID:11723774

Mathoulin, C; Sbihi, A; Panciera, P

2001-10-01

157

Complex Role of TNF Variants in Psoriatic Arthritis and Treatment Response to Anti-TNF Therapy: Evidence and Concepts.  

PubMed

Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints, and it may manifest as peripheral arthritis, dactylitis, enthesitis, spondylitis, or sacroiliitis. In the great majority of patients, PsA is accompanied by the most frequent psoriatic manifestation-psoriasis vulgaris. The major genetic risk factor for PsA is an HLA-C allele, and in recent genome-wide association studies few other susceptibility loci have as yet been identified. In this issue, Murdaca et al. (2014) describe an association of an intronic single-nucleotide polymorphism at the TNF locus (+489) with PsA, disease severity, and treatment responses to tumor necrosis factor-? blockers. PMID:25219647

Hüffmeier, Ulrike; Mössner, Rotraut

2014-10-01

158

The Auditory Brain-Stem Response to Complex Sounds: A Potential Biomarker for Guiding Treatment of Psychosis  

PubMed Central

Cognitive deficits limit psychosocial functioning in schizophrenia. For many patients, cognitive remediation approaches have yielded encouraging results. Nevertheless, therapeutic response is variable, and outcome studies consistently identify individuals who respond minimally to these interventions. Biomarkers that can assist in identifying patients likely to benefit from particular forms of cognitive remediation are needed. Here, we describe an event-related potential (ERP) biomarker – the auditory brain-stem response (ABR) to complex sounds (cABR) – that appears to be particularly well-suited for predicting response to at least one form of cognitive remediation that targets auditory information processing. Uniquely, the cABR quantifies the fidelity of sound encoded at the level of the brainstem and midbrain. This ERP biomarker has revealed auditory processing abnormalities in various neurodevelopmental disorders, correlates with functioning across several cognitive domains, and appears to be responsive to targeted auditory training. We present preliminary cABR data from 18 schizophrenia patients and propose further investigation of this biomarker for predicting and tracking response to cognitive interventions. PMID:25352811

Tarasenko, Melissa A.; Swerdlow, Neal R.; Makeig, Scott; Braff, David L.; Light, Gregory A.

2014-01-01

159

Space Complexity Algorithms & Complexity  

E-print Network

Space Complexity Algorithms & Complexity Space Complexity Nicolas Stroppa Patrik Lambert - plambert@computing.dcu.ie CA313@Dublin City University. 2008-2009. December 4, 2008 #12;Space Complexity Hierarchy of problems #12;Space Complexity NP-intermediate Languages If P = NP, then are there languages which neither in P

Way, Andy

160

Early clinical evaluation of the intravenous treatment of acute myocardial infarction with anisoylated plasminogen streptokinase activator complex.  

PubMed

50 consecutive patients with acute myocardial infarction and symptoms of less than 4 hours duration were treated with anisoylated plasminogen streptokinase activator complex (APSAC) 30U intravenously as a bolus injection over 5 minutes. An open infarct-related artery was found in 32 patients (64%) when the first coronary angiography was taken 66 +/- 21 minutes after APSAC. Complete reperfusion was subsequently seen in 10 of 18 patients with an occluded infarct-related artery 74 +/- 16 minutes after injection of APSAC. Thus, a patient infarct-related artery was seen in 42 patients (84%) within 68 +/- 20 minutes. A control coronary angiography was performed in 37 patients (74%) after 25 +/- 19 days. Reocclusion was found in 5 patients. The minimal cross-sectional area of the residual coronary stenosis increased from 1.3 +/- 0.9 mm2 to 1.8 +/- 1.9 mm2. Patients with residual thrombi after coronary thrombolysis (n = 13) demonstrated an increase of the minimal cross-sectional area of the residual stenosis from 1.2 +/- 0.8 to 2.6 +/- 2.3 mm2, whereas those without residual thrombi showed only minor changes of the minimal cross-sectional area (1.3 +/- 0.9 to 1.2 +/- 1.2 mm2). Thus, APSAC demonstrated a high patency rate and a low reocclusion rate after intravenous administration. The prolonged fibrinolytic activity of APSAC leads to a further regression of the residual coronary stenosis among patients with coronary thrombi after reperfusion. PMID:3315575

Kasper, W; Meinertz, T; Wollschläger, H; Bonzel, T; Chen, C; Hofmann, T; Zeiher, A; Drexler, H; Just, H

1987-01-01

161

Cumulative area pre-processing (CAP): a new treatment of UV data for the analysis of complex pharmaceutical mixtures.  

PubMed

A new approach to pre-processing of the UV spectral data in combination with chemometric techniques, aiming to obtain a significant amplification of the analytical information, is proposed. The single areas under the curve between two consecutive wavelengths were calculated along the full spectrum and therefore their cumulative sum was carried out. The method was called "cumulative area pre-processing" (CAP) and applied to multicomponent pharmaceutical formulations to test its performance in improving the accuracy of the analysis. The proposed procedure has demonstrated high ability in the quantitative determination of the components present in very low amount compared to other. Three multicomponent drug formulations were analyzed by applying the partial least squares (PLS) algorithm to the UV data processed by CAP and the results compared with those carried out by using the same data without treatment and after derivative transformation. The best results in the determination of the components present in lower concentrations were obtained by applying the PLS models calculated on data processed by CAP and confirmed in the analysis of marketed drug products. PMID:24321517

De Luca, Michele; Ioele, Giuseppina; Ragno, Gaetano

2014-03-01

162

[Pulmonary scintigraphy in evaluating the efficiency of surfactant therapy in the complex treatment of patients with destructive pulmonary tuberculosis].  

PubMed

Functional impairments of the mucociliary system (MCS) are known to develop in destructive tuberculous inflammation in the lung tissue. The effect of surfactant agents and their production stimulants is to recover the ventilation and gas exchange functions of the lung. The radioaerosol technique that adequately characterizes the deposition of an inhaled agent in the bronchial tree and records the state of mucociliary clearance (MCC) and MCS in different portions of the lung by the rate of tracer washout is of the greatest information value for the evaluation of MCC in vivo. Its normal values are in rather wide ranges so the absolute values are of low informative value. By taking into account the variability in the tracer washout range in health, the authors used only the time course of relative changes in this parameter--before and after surfactant therapy. The capacities of pulmonary scintigraphy were employed to monitor the efficiency of treatment for tuberculosis. The percentage of the activities in the areas of the right and left lung individually and in combination was estimated, by constructing the tracer washout curve. The percentage of 60-minute tracer washout was borne in mind to determine the rate of MCC. PMID:17195630

Chernichenko, N V; Sigaev, A T; Lovacheva, O V; Erokhin, V V

2006-01-01

163

Delamination technique together with longitudinal incisions for treatment of Chiari I/syringomyelia complex: a prospective clinical study  

PubMed Central

Background Treatment modalities in Chiari malformation type 1(CMI) accompanied by syringomyelia have not yet been standardized. Pathologies such as a small posterior fossa and thickened dura mater have been discussed previously. Various techniques have been explored to enlarge the foramen magnum and to expand the dura. The aim of this clinical study was to explore a new technique of excision of the external dura accompanied by widening the cisterna magna and making longitudinal incisions in the internal dura, without disturbing the arachnoid. Methods Ten patients with CMI and syringomyelia, operated between 2004 and 2006, formed this prospective series. All cases underwent foramen magnum decompression of 3 × 3 cm area with C1–C2 (partial) laminectomy, resection of foramen magnum fibrous band, excision of external dura, delamination and widening of internal dura with longitudinal incisions. Results Patients were aged between 25 and 58 years and occipital headache was the most common complaint. The mean duration of preoperative symptoms was 4 years and the follow-up time was 25 months. Clinical progression was halted for all patients; eight patients completely recovered and two reported no change. In one patient, there was a transient cerebrospinal fluid (CSF) fistula that was treated with tissue adhesive. While syringomyelia persisted radiologically with radiological stability in five patients; for three patients the syringomyelic cavity decreased in size, and for the remaining two it regressed completely. Conclusion Removal of the fibrous band and the outer dural layer, at level of foramen magnum, together with the incision of inner dural layer appears to be good technique in adult CMI patients. The advantages are short operation time, no need for duraplasty, sufficient posterior fossa decompression, absence of CSF fistulas as a result of extra arachnoidal surgery, and short duration of hospitalization. Hence this surgical technique has advantages compared to other techniques. PMID:19545443

Kotil, Kadir; Ton, Tugrul; Tari, Rabia; Savas, Yildiray

2009-01-01

164

Doxorubicin Lipid Complex Injection  

MedlinePLUS

Doxorubicin lipid complex is used to treat ovarian cancer that has not improved or that has worsened after treatment with other medications. Doxorubicin lipid complex is also used to treat Kaposi's sarcoma ( ...

165

Vincristine Lipid Complex Injection  

MedlinePLUS

Vincristine lipid complex is used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer ... least two different treatments with other medications. Vincristine lipid complex is in a class of medications called ...

166

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.  

PubMed Central

Experimental autoimmune encephalomyelitis (EAE) is a class II major histocompatibility complex (MHC)-restricted, T-cell-mediated, demyelinating autoimmune disease of the central nervous system and represents a model for human multiple sclerosis. The present study demonstrates that vaccination of SJL/J mice with an 18-amino acid synthetic peptide from the third hypervariable region of the murine class II MHC IAs beta chain (IAs beta 58-75; 18-mer peptide) is capable of eliciting auto-anti-IAs antibodies specific for the IAs beta chain and preventing and treating EAE. A similar approach may be useful in the treatment of human autoimmune diseases in which susceptibility is linked to class II MHC genes. Images PMID:8058747

Topham, D J; Nag, B; Arimilli, S; Sriram, S

1994-01-01

167

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.  

PubMed

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for the treatment of Alzheimer's disease. At nano- and subnanomolar concentrations they inhibit human acetyl- and butyrylcholinesterase (AChE and BuChE), being more potent than tacrine. They also displace propidium iodide from the peripheral anionic site of AChE and thus could be able to inhibit Abeta aggregation promoted by AChE. They show better antioxidant properties than Trolox, the aromatic portion of vitamin E responsible for radical capture, and display neuroprotective properties against mitochondrial free radicals. In addition, they selectively complex Cu(II), show low cell toxicity, and could be able to penetrate the CNS, according to an in vitro blood-brain barrier model. PMID:20545360

Fernández-Bachiller, María Isabel; Pérez, Concepción; González-Muñoz, Gema C; Conde, Santiago; López, Manuela G; Villarroya, Mercedes; García, Antonio G; Rodríguez-Franco, María Isabel

2010-07-01

168

Therapeutic Response of Vitamin A, Vitamin B Complex, Essential Fatty Acids (EFA) and Vitamin E in the Treatment of Phrynoderma: A Randomized Controlled Study  

PubMed Central

Background: In the treatment of phrynoderma, various nutrients have been tried in different dosages and routes with variable therapeutic outcomes. Aims: The present study was undertaken to compare the efficacy of various nutrients in the treatment of phrynoderma. Settings and Design: An open label randomized controlled study was conducted in the out-patient department of Dermatology in a tertiary care hospital. Material and Methods: The patients were divided into group of five and each patient received one of the five regimens [10 injections of Vitamin A 1 lakh units, intramuscularly (IM) on alternate day, 10 injections of Vitamin B complex, 2cc IM on alternate day, 2 table spoon of safflower oil, two times daily with meals, Tab Vitamin E 400mg once daily, and only topical keratolytic (salicylic acid 3% ointment) two times daily] respectively. The first four regimens also received topical keratolytic. The primary outcome measured was therapeutic response at the end of regimen. The response was graded based on the percentage of flattening and decrease in number of lesions. Less than 25% improvement was graded as poor, 26-50% improvement as moderate, 51-75% improvement as good, and more than 75% improvement as excellent response. In the statistical analysis, comparison was done using Chi-square and Fisher’s exact test. Results: A total of 125 patients were included in the study with 25 patients each in five regimen groups. There were 79 (63.2%) males and 46 (36.8%) females with a ratio of 1.72:1. The age of the patients ranged from 3 to 26 years with mean of 10.1±4.3 years. Out of 125 patients, 105 completed the study. In regimen 1 and 2, significant number of patients showed good to excellent response whereas significant number of patients in remaining regimen showed moderate to poor response with a p value of <0.05. The therapeutic response to Vitamin A and Vitamin B complex therapy was significantly better than other regimens. Conclusion: Intramuscular injections of Vitamin A or Vitamin B are effective in the treatment of phrynoderma. Addition of topical keratolytics helps in faster clearance of keratotic lesions. PMID:24596740

S., Ragunatha; Kumar V., Jagannath; S.B., Murugesh; M., Ramesh; G., Narendra; Kapoor, Meenakshi

2014-01-01

169

Treatment of Children with Protein - Losing Enteropathy After Fontan and Other Complex Congenital Heart Disease Procedures in Condition with Limited Human and Technical Resources  

PubMed Central

Background Protein-losing enteropathy (PLE) is a disorder characterized by abnormal and often profound enteric protein loss. It’s relatively uncommon complication of Fontan and other complex congenital heart disease (CCHD) procedures. Because of the complexity and rarity of this disease process, the pathogenesis and pathophysiology of protein-losing enteropathy remain poorly understood, and attempts at treatment seldom yield long-term success. Aim of presentation is to describe single centre experience in diagnosis, evaluation, management and treatment of children with protein-losing enteropathy after Fontan and other CCHD procedures in the current era and in centre with limited human and technical resources, follows with a comprehensive review of protein-losing enteropathy publications, and concludes with suggestions for prevention and treatment. Material and methodology Retrospectively we analyzed patients with CCHD and protein-losing enteropathy in our institution, starting from January 2000 to December 2012. The including criteria were age between two and 17 years, to have a complex congenital heart disease and available complete documentation of cardiac surgery under cardiopulmonary bypass. Results Of all patients we evaluated 18 cases with protein-losing enteropathy, aged 6 to 19 years (mean 14±9); there were three children who had undergone screening procedure for D-transposition, one Tetralogy of Fallot, and remaining 14 patients had undergone Fontan procedures; (anatomic diagnosis are: six with tricuspid atresia, seven with d-transposition, double outlet right ventricle and pulmonary atresia and two with hypoplastic left heart syndrome). The diagnosis of protein-losing enteropathy was made at median age of 5.6 years, ranging from 13 months to 15 years. Diagnosis was made using alpha 1-antitrypsin as a gold marker in stool. By physical examination in 14 patients edema was found, in three ascites, and six patients had pleural effusion. Laboratory findings at the time of diagnosis are: abnormal enteric protein loss was documented at the time of diagnosis in all 18 patients. At the time of diagnosis all patients receiving some form of anticoagulation, 17 patients receiving other medication: 17 – diuretics and ACE inhibitors, 12 digoxin, 9 antiarrhytmics. Cross-sectional echocardiography was performed for all patients and different abnormalities were registered. In 14 patients also magnetic resonance was performed. Therapeutic approach was based on the non-specific medication (diet, diuretics, digoxin, ACE inhibitors, and anticoagulants), heparin and corticosteroids therapy. Long-term response to this type of therapy was registered in three patients. Nine patients underwent treatment with heparin and corticosteroids and no one experienced long term benefit. Despite of needs for catheter therapy or surgical intervention in our study, in the absent of technical and human resources now any one had underwent those procedures. Six patients has been transferred abroad and in five of them surgical intervention was perform. Conclusion Protein-losing enteropathy remains a devastating complication of Fontan procedure and despite in advantages in surgical and medical therapy there is no evidence that protein-losing enteropathy is less common in the current area. PMID:24757400

Bejiqi, Ramush; Retkoceri, Ragip; Zeka, Naim; Bejiqi, Hana; Vuqiterna, Armend; Maloku, Arlinda

2014-01-01

170

Connections and consequences in complex systems: insights from a case study of the emergence and local impact of crisis resolution and home treatment services.  

PubMed

In this article the broad contours of a complexity perspective are outlined. Complexity ideas are then drawn on to frame an empirical examination of the connections running between different levels of organisation in health and social care, and to underpin investigation into the intended and unintended local system consequences of service development. Data are used from a study conducted in the UK's mental health field. Here, macro-level policy has led to the supplementing of longstanding community mental health teams by newer, more specialised, services. An example includes teams providing crisis resolution and home treatment (CRHT) care as an alternative to hospital admission. Using an embedded case study design, where 'the case' examined was a new CRHT team set in its surrounding organisational environment, ethnographic data (with interviews predominating) were generated in a single site in Wales over 18 months from the middle of 2007. In a large-scale context favourable to local decision-making, and against a background of a partial and disputed evidence base, the move to establish the new standalone service was contested. Whilst users valued the work of the team, and local practitioners recognised the quality of its contribution, powerful effects were also triggered across the locality's horizontal interfaces. Participants described parts of the interconnected system being closed to release resources, staff gravitating to new crisis services leaving holes elsewhere, and the most needy service users being cared for by the least experienced workers. Some community mental health team staff described unexpected increases in workload, and disputes over eligibility for crisis care with implications for system-wide working relations. Detailed data extracts are used to illustrate these connections and consequences. Concluding lessons are drawn on the use of evidence to inform policy, on the significance of local contexts and system interfaces, and on anticipating the unexpected at times of change. PMID:22386638

Hannigan, Ben

2013-09-01

171

Ulnar shortening after TFCC suture repair of Palmer type 1B lesions  

Microsoft Academic Search

Purpose  The objective of this study was to determine functional and subjective outcomes of an ulnar shortening procedure elected by\\u000a patients who experienced persistent ulno-carpal symptoms following arthroscopic suture repair of a Palmer type 1B lesion.\\u000a All patients had a dynamic ulna positive variance.\\u000a \\u000a \\u000a \\u000a Methods  Five patients (3 males and 2 females) with arthroscopic repair of Palmer type 1B tears who subsequently

Maya B. Wolf; Markus W. Kroeber; Andreas Reiter; Susanne B. Thomas; Peter Hahn; Raymund E. Horch; Frank Unglaub

2010-01-01

172

In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model  

PubMed Central

Background Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. Methods Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. Results We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. Conclusion The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies. PMID:20338038

2010-01-01

173

Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion: A Drug Complex of Natural Extracts and Inorganic Compounds  

PubMed Central

Ekybion is a drug complex of 16 natural extracts and inorganic compounds designed to treat a variety of respiratory pathogens of bacterial and viral origin. It is licensed throughout Europe for the treatment of respiratory tract infections from equine parainfluenza type 3 and equine herpes virus type 1 in equine stables. The purpose of this paper was to test the efficacy of Ekybion on a well-developed animal model of influenza A infection and determine a mode of action. Experiments were performed with Balb/c mice infected with a lethal dose of influenza A/PR/8/34 H1N1 virus and treated with nebulized Ekybion every 8?h in a time-dependant or dose-dependant fashion. These experiments showed that mice treated prior to infection with Ekybion had a higher survival rates (~46%) compared with untreated animals (~0%). Paradoxically, these mice showed no significant difference in lung virus titer or weight loss. There was, however, a decrease in the level of GM-CSF, IL-6, and G-CSF cytokines in the lungs of Ekybion-treated, infected mice. It is possible that decreases in proinflammatory cytokines may have contributed to increased survivorship in Ekybion-treated influenza-infected mice. PMID:20981272

Lupfer, Christopher; Besnouin, Didier; Tepper, Samuel E.; Maselko, Maciej; Patton, Kristin M.; Pastey, Manoj

2011-01-01

174

Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: implications for second-line therapy.  

PubMed

Protease inhibitor (PI)-based antiretroviral therapy (ART) can effectively suppress HIV-2 plasma load and increase CD4 counts; however, not all PIs are equally active against HIV-2, and few data exist to support second-line therapy decisions. To identify therapeutic options for HIV-2 patients failing ART, we evaluated the frequency of PI resistance-associated amino acid changes in HIV-2 sequences from a cohort of 43 Senegalese individuals receiving unboosted indinavir (n = 18 subjects)-, lopinavir/ritonavir (n = 4)-, or indinavir and then lopinavir/ritonavir (n = 21)-containing ART. Common protease substitutions included V10I, V47A, I54M, V71I, I82F, I84V, L90M, and L99F, and most patients harbored viruses containing multiple changes. Based on genotypic data, we constructed a panel of 15 site-directed mutants of HIV-2ROD9 containing single- or multiple-treatment-associated amino acid changes in the protease-encoding region of pol. We then quantified the susceptibilities of the mutants to the HIV-2 "active" PIs saquinavir, lopinavir, and darunavir using a single-cycle assay. Relative to wild-type HIV-2, the V47A mutant was resistant to lopinavir (6.3-fold increase in the mean 50% effective concentration [EC50]), the I54M variant was resistant to darunavir and lopinavir (6.2- and 2.7-fold increases, respectively), and the L90M mutant was resistant to saquinavir (3.6-fold increase). In addition, the triple mutant that included I54M plus I84V plus L90M was resistant to all three PIs (31-, 10-, and 3.8-fold increases in the mean EC50 for darunavir, saquinavir, and lopinavir, respectively). Taken together, our data demonstrate that PI-treated HIV-2 patients frequently harbor viruses that exhibit complex patterns of PI cross-resistance. These findings suggest that sequential PI-based regimens for HIV-2 treatment may be ineffective. PMID:23571535

Raugi, Dana N; Smith, Robert A; Ba, Selly; Toure, Macoumba; Traore, Fatou; Sall, Fatima; Pan, Charlotte; Blankenship, Lindsey; Montano, Alexandra; Olson, Julia; Dia Badiane, Ndeye Mery; Mullins, James I; Kiviat, Nancy B; Hawes, Stephen E; Sow, Papa Salif; Gottlieb, Geoffrey S

2013-06-01

175

Aortic arch/elephant trunk procedure with SiennaTM graft and endovascular stenting of thoraco-abdominal aorta for treatment of complex chronic dissection  

PubMed Central

Aneurismal dilatation of the remaining thoracic aorta after ascending aortic interposition grafting for type ‘A’ aortic dissection is not uncommon. For such complex cases, one treatment option is total arch replacement and elephant trunk procedure with the SiennaTM collared graft (Vascutek, Inchinnan, UK) technique followed by a staged thoracic endovascular aortic repair (TEVAR). The video illustrates our technique in a 56-year-old man with an extensive aortic arch and descending thoracic aortic dissecting aneurysm. For the ‘open’ procedure femoral arterial and venous cannulation was used along with systemic cooling and circulatory arrest at 22 °C. Upon circulatory arrest, the aortic arch was incised and antegrade cerebral perfusion achieved via selective cannulation to the right brachiocephalic and left common carotid artery, keeping flow rates at 10-15 mL/kg/min and perfusion pressure at 50-60 mmHg. Arch replacement with an elephant trunk component was then performed and after completion of the distal aortic anastomosis antegrade perfusion via a side-arm in the graft was started and the operation completed using a variation of the ‘sequential’ clamping technique to maximize cerebral perfusion. The second endovascular stage was performed two weeks after discharge. Two covered stents were landing from the elephant trunk to the distal descending thoracic aorta, to secure the distal landing a bare stent of was placed to cover the aorta just distal to the origin of the celiac axis. The left subclavian artery was embolised with fibre coils. Post TEVAR angiogram showed no endoleak Although re-operative total arch replacement and elephant trunk procedure and subsequent TEVAR remained a challenging procedure, we believe excellent surgical outcome can be achieved with carefully planned operative strategy. PMID:23977606

Wong, Randolph H.L.; Baghai, Max; Yu, Simon C.H.

2013-01-01

176

Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes.  

PubMed

The effects of exogenous hormones, used for estrus synchronization and ovarian hyper stimulation, on cumulus oocyte complexes (COCs) gene expression in sexually mature rats were determined using microarrays. Gene expression in COCs collected from GnRH (G(trt)), GnRH + eCG (G + E(trt)), and GnRH + eCG + hCG (G + E + H(trt)) treatments were compared to COCs from naturally cycling (NC) rats before the preovulatory luteninizing hormone surge. There was no significant difference in gene expression among NC, G(trt), and G + E(trt); however, over 2,600 genes were significantly different between NC and G + E + H(trt) (P < 0.05). Genes upregulated in G + E + H(trt) encode for: proteins that are involved in prostaglandin synthesis (Ptgs2, Pla2g4a, and Runx1) and cholesterol biosynthesis (Hmgcr, Sc4mol, and Dhcr24); receptors that allow cholesterol uptake (Ldlr and Scarb1), regulate progesterone synthesis (Star), and inactivate estrogen (Sult1e1); and downstream effectors of LH signal (Pgr, Cebpb, Creb3l1, Areg, Ereg, and Adamts1). Conversely, G + E + H(trt) downregulated genes encoding proteins involved in: DNA replication and cell cycle progression (Ccne2, Orc5l, Rad50, and Mcm6); reproductive developmental process; and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgfb2, Foxl2, Pde3a, Esr2, Fshr, Ybx2, Ccnd2, Ccnb1ip1, and Zp3); maternal effect genes required for embryo development (Zar1, Npm2, Nlrp5, Dnmt1, H1foo, and Zfp57); amino acid degradation; and ketogenesis (Hmgcs2, and Cpt1b). These results from the rat show that hormones used for estrus synchronization (G(trt)) and ovarian hyper stimulation (G + E(trt)) had minimal effects on gene expression, whereas induction of ovulation (G + E + H(trt)) caused major changes in gene expression of rat COCs. This study provides comprehensive information about regulated genes during late follicle development and ovulation induction. PMID:23239112

Agca, Cansu; Yakan, Akin; Agca, Yuksel

2013-02-01

177

[Intravascular laser irradiation of blood in complex treatment of obliterating atherosclerosis of the lower extremity vessels in elderly and senile patients].  

PubMed

The authors describe comparative results of treatment of 60 elderly and senile patients with obliterating atherosclerosis of the lower extremity vessels. In 50 patients treatment with traditional medicines was combined with intravascular laser irradiation of blood, 10 patients were treated with traditional medicines only. The data obtained by questionnaires concerning the patients' state, expert judgment of doctors in charge of the profile department, indices of instrumental examinations of regional hemodynamics (rheovasography of the lower extremity vessels), data of laboratory investigations of morphofunctional state of erythrocytes and hemorheology showed that laser irradiation of blood gave better results of treatment. Its therapeutic effect persisted during 3 months in most patients. PMID:17120419

Iaitski?, N A; Ageenko, E M; Davydenko, T E; Volchkov, V A; Churzin, O A; Zharskaia, V D

2006-01-01

178

Routine depression screening in an HIV clinic cohort identifies patients with complex psychiatric co-morbidities who show significant response to treatment.  

PubMed

This study described characteristics, psychiatric diagnoses and response to treatment among patients in an outpatient HIV clinic who screened positive for depression. Depressed (25 %) were less likely to have private insurance, less likely to have suppressed HIV viral loads, had more anxiety symptoms, and were more likely to report current substance abuse than not depressed. Among depressed, 81.2 % met diagnostic criteria for a depressive disorder; 78 % for an anxiety disorder; 61 % for a substance use disorder; and 30 % for co-morbid anxiety, depression, and substance use disorders. Depressed received significantly more treatment for depression and less HIV primary care than not depressed patients. PHQ-9 total depression scores decreased by 0.63 from baseline to 6-month follow-up for every additional attended depression treatment visit. HIV clinics can routinely screen and treat depressive symptoms, but should consider accurate psychiatric diagnosis as well as co-occurring mental disorders. PMID:23086427

Schumacher, Joseph E; McCullumsmith, Cheryl; Mugavero, Michael J; Ingle-Pang, Paige E; Raper, James L; Willig, James H; You, Zhiying; Batey, D Scott; Crane, Heidi; Lawrence, Sarah T; Wright, Charles; Treisman, Glenn; Saag, Michael S

2013-10-01

179

Case files of the Medical Toxicology Fellowship at the Toxikon Consortium in Chicago: Cocaine-associated wide-complex dysrhythmias and cardiac arrest— treatment nuances and controversies  

Microsoft Academic Search

Conclusion  Manifestations of cocaine poisoning range widely from mild sympathomimetic overdrive to life-threatening seizures, hyperthermia,\\u000a and cardiac dysrhythmias. While supportive care, including the judicious use of benzodiazepines and cooling measures, is paramount,\\u000a the management of cocaine-associated wide-complex dysrhythmias and cardiac arrest regularly includes sodium bicarbonate boluses\\u000a in order to narrow QRS length. When confronted with refractory dysrhythmias, one must weigh the

Ejaaz A. Kalimullah; Sean M. Bryant

2008-01-01

180

The use of a low-profile Ilizarov external fixator in the treatment of complex fractures and non-unions of the distal femur  

Microsoft Academic Search

The aim of this study was to assess the effectiveness of a modified (low-profile) Ilizarov fixation in the treat - ment of complex fractures of the distal femur such asseptic or aseptic non-unions following previous sur - geries, osteoporotic fractures, and high-grade open fractures. Ten male patients with a mean age of 50 years (range, 22-72 years) were treated with

Veysel Ercan; Kerem B ASARIR; Mahmut U GURLU; Ali Turgay Cavusoglu; Abdurrahman Sakaogullari; Mahmut Ugurlu; Kerem Basarir

2009-01-01

181

Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a number of sulfadrug azodyes and their application for wastewater treatment.  

PubMed

The azodye ligand (HL(1)) was synthesized from the coupling of sulfaguanidine diazonium salt with 2,4-dihydroxy-benzaldehyde while the two ligands, HL(2) and HL(3), were prepared by the coupling of sulfadiazine diazonium salt with salicylaldehyde (HL(2)) and 2,4-dihydroxy-benzaldehyde (HL(3)). The prepared ligands were characterized by elemental analysis, IR, (1)H NMR and mass spectra. Cu(II), Co(II) and Ni(II) complexes of the prepared ligands have been synthesized and characterized by various spectroscopic techniques like IR, UV-Visible as well as magnetic and thermal (TG and DTA) measurements. It was found that all the ligands behave as a monobasic bidentate which coordinated to the metal center through the azo nitrogen and ?-hydroxy oxygen atoms in the case of HL(1) and HL(3). HL(2) coordinated to the metal center through sulfonamide oxygen and pyrimidine nitrogen. The applications of the prepared complexes in the oxidative degradation of indigo carmine dye exhibited good catalytic activity in the presence of H2O2 as an oxidant. The reactions followed first-order kinetics and the rate constants were determined. The degradation reaction involved the catalytic action of the azo-dye complexes toward H2O2 decomposition, which can lead to the generation of HO radicals as a highly efficient oxidant attacking the target dye. The detailed kinetic studies and the mechanism of these catalytic reactions are under consideration in our group. PMID:24239761

El-Baradie, K; El-Sharkawy, R; El-Ghamry, H; Sakai, K

2014-01-01

182

Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve  

PubMed Central

A 10-year-old girl with trisomy 21 and complex congenital heart disease presented with acute lymphoblastic leukemia. Her chemotherapy required modifications due to poor baseline cardiac status and a mechanical prosthetic heart valve that was dependent on anticoagulation. We describe our management including the use of low-molecular-weight heparin as anticoagulation for a mechanical heart valve, the safe delivery of intrathecal chemotherapy included bridging with unfractionated heparin, and the use of fluoroscopic guidance to minimize the risk of bleeding. Adjustments were made to avoid anthracyclines. The child tolerated therapy well without complications and remains relapse free five years after diagnosis. PMID:23082266

Alvi, Saima; Shereck, Evan; Heran, Manraj K. S.; Sandor, George G. S.; Rassekh, Shahrad Rod

2012-01-01

183

Propranolol in Use for Treatment of Complex Infant Hemangiomas: Literature Review Regarding Current Guidelines for Preassessment and Standards of Care before Initiation of Therapy  

PubMed Central

In 2008, the positive effects of propranolol on infantile hemangiomas (IH) have been discovered serendipitously by Léauté-Labrèze and her coworkers. Since then, propranolol has been in use in allday clinical practice worldwide for treatment of IH. It even caused some kind of paradigm shift in the overall management of these lesions, though propranolol is still not FDA approved, respectively, in “off-label” use for this indication in the majority of institutions. Thus, the aim of this communication is to evaluate the literature for current evidence regarding guidelines for preassessment and standards of care before initiation of therapy. PMID:23766715

Fette, Andreas

2013-01-01

184

A modified posteromedial approach combined with extensile anterior for the treatment of complex tibial pilon fractures (AO/OTA 43-C).  

PubMed

The anterior approaches that have been described for open reduction internal fixation of multifragmentary pilon fractures are designed to reconstruct the comminuted and impacted anterior articular surface onto a stable posterior column. Thus, reduction of the posterior column, particularly proper length, is critical. There are differing opinions of how best to surgically approach the posterior pilon fracture. There is also no clear indication as to the timing of both anterior and posterior reconstructions. Our objectives were (1) to develop a more midline posterior approach that might provide better visualization of the posterior aspect of the posterior column and juxtametaphyseal/diaphyseal parts of the tibia, first on the cadaver and then with patients, and (2) to use this as part of a combined posterior and anterior approach during the same anesthesia for complex tibial pilon fractures (AO/OTA 43-C) in a preliminary study of 6 patients. PMID:24857906

Assal, Mathieu; Ray, Adrien; Fasel, Jean H D; Stern, Richard

2014-06-01

185

Cultural Complexity  

Microsoft Academic Search

This paper is divided into four parts. The first section (I.) consists of definitions which center on the concept of complexity. As a minimum, the terms, system, complexity, and adaptation as used in this paper need an explanation. The second section (II.) is a sketch of cultural complexity in the real world. I will use Pueblo tribal laws and other

Wolfgang Fikentscher

1998-01-01

186

Phonological Complexity and Language Learnability  

PubMed Central

Purpose To extend formal models of language learnability to applications in clinical treatment of children with functional phonological delays. Method The focus of the narrative review is on phonological complexity. This follows from learnability theory, whereby complexity in the linguistic input to children has been shown to trigger language learning. Drawing from the literature, phonological complexity is defined from epistemic, ontological, and functional perspectives, with specific emphasis on the application of language universals in the selection of target sounds for treatment. Results The cascading effects of phonological complexity on children’s generalization learning are illustrated, and frequently asked questions about complexity in treatment are addressed. Conclusion The role of complexity in cognitive development is introduced to demonstrate the apparent robustness of effects. PMID:17329671

Gierut, Judith A.

2008-01-01

187

Toward a 3D Cellular Model for Studying In Vitro the Outcome of Photodynamic Treatments: Accounting for the Effects of Tissue Complexity  

PubMed Central

Clinical therapies have traditionally been developed using two-dimensional (2D) cell culture systems, which fail to accurately capture tissue complexity. Therefore, three-dimensional (3D) cell cultures are more attractive platforms to integrate multiple cues that arise from the extracellular matrix and cells, closer to an in vivo scenario. Here we report the development of a 3D cellular model for the in vitro assessment of the outcome of oxygen- and drug-dependent therapies, exemplified by photodynamic therapy (PDT). Using a synthetic self-assembling peptide as a cellular scaffold (RAD16-I), we were able to recreate the in vivo limitation of oxygen and drug diffusion and its biological effect, which is the development of cellular resistance to therapy. For the first time, the production and decay of the cytotoxic species singlet oxygen could be observed in a 3D cell culture. Results revealed that the intrinsic mechanism of action is maintained in both systems and, hence, the dynamic mass transfer effects accounted for the major differences in efficacy between the 2D and 3D models. We propose that this methodological approach will help to improve the efficacy of future oxygen- and drug-dependent therapies such as PDT. PMID:23442191

Alemany-Ribes, Mireia; García-Díaz, María; Busom, Marta; Nonell, Santi

2013-01-01

188

Toward a 3D cellular model for studying in vitro the outcome of photodynamic treatments: accounting for the effects of tissue complexity.  

PubMed

Clinical therapies have traditionally been developed using two-dimensional (2D) cell culture systems, which fail to accurately capture tissue complexity. Therefore, three-dimensional (3D) cell cultures are more attractive platforms to integrate multiple cues that arise from the extracellular matrix and cells, closer to an in vivo scenario. Here we report the development of a 3D cellular model for the in vitro assessment of the outcome of oxygen- and drug-dependent therapies, exemplified by photodynamic therapy (PDT). Using a synthetic self-assembling peptide as a cellular scaffold (RAD16-I), we were able to recreate the in vivo limitation of oxygen and drug diffusion and its biological effect, which is the development of cellular resistance to therapy. For the first time, the production and decay of the cytotoxic species singlet oxygen could be observed in a 3D cell culture. Results revealed that the intrinsic mechanism of action is maintained in both systems and, hence, the dynamic mass transfer effects accounted for the major differences in efficacy between the 2D and 3D models. We propose that this methodological approach will help to improve the efficacy of future oxygen- and drug-dependent therapies such as PDT. PMID:23442191

Alemany-Ribes, Mireia; García-Díaz, María; Busom, Marta; Nonell, Santi; Semino, Carlos E

2013-08-01

189

Fourier-transform spectroscopy and coupled-channels deperturbation treatment of the A {sup 1{Sigma}+}-b {sup 3{Pi}} complex of KCs  

SciTech Connect

The laser-induced fluorescence (LIF) A {sup 1{Sigma}+}-b {sup 3{Pi}{yields}}X {sup 1{Sigma}+} spectra of the KCs molecule were recorded in a near infrared region by a Fourier-transform spectrometer with a resolution of 0.03 cm{sup -1}. Overall more than 200 collisionally enhanced LIF spectra were rotationally assigned to {sup 39}K{sup 133}Cs and {sup 41}K{sup 133}Cs isotopomers yielding more than 3400 rovibronic term values of the strongly mixed singlet A {sup 1{Sigma}+} and triplet b {sup 3{Pi}} states with the uncertainty of 0.003-0.01 cm{sup -1}. Experimental data massive starts from the lowest vibrational level v{sub A}=0 of the singlet and nonuniformly covers the energy range E is an element of [10 040,13 250] cm{sup -1} with rotational quantum numbers J{sup '} is an element of [7,225]. Besides the dominating regular A {sup 1{Sigma}+}-b {sup 3{Pi}}{sub {Omega}=0} interactions, the weak local heterogeneous A {sup 1{Sigma}+}-b {sup 3{Pi}}{sub {Omega}=1} perturbations have been discovered and analyzed. Coupled-channels deperturbation analysis of the experimental {sup 39}K{sup 133}Cs e-parity term values of the A {sup 1{Sigma}+}-b {sup 3{Pi}}{sub {Omega}=0,1,2} complex was accomplished in the framework of the phenomenological 4x4 Hamiltonian accounting implicitly for regular interactions with the remote {sup 1{Pi}} and {sup 3{Sigma}+} states. The diabatic potential energy curves of the A {sup 1{Sigma}+} and b {sup 3{Pi}} states, as well as relevant spin-orbit coupling matrix elements, were defined analytically with the expanded Morse oscillators model. The obtained parameters reproduce 95% of experimental data field of the {sup 39}K{sup 133}Cs isotopomer with a standard deviation of 0.004 cm{sup -1}, which is consistent with the uncertainty of the experiment. Reliability of the derived parameters was confirmed by a good agreement between the predicted and experimental term values of the {sup 41}K{sup 133}Cs isotopomer. The calculated relative intensity distributions in A-b{yields}X LIF progressions are also consistent with their experimental counterparts. The deperturbation model was applied for simulation of a pump-dump optical cycle a {sup 3{Sigma}+{yields}}A {sup 1{Sigma}+}-b {sup 3{Pi}{yields}}X {sup 1{Sigma}+} proposed for transformation of ultracold KCs molecules to their absolute ground state v{sub X}=0;J{sub X}=0.

Kruzins, A.; Klincare, I.; Nikolayeva, O.; Tamanis, M.; Ferber, R.; Pazyuk, E. A.; Stolyarov, A. V. [Laser Center, University of Latvia, Rainis Boulevard 19, LV-1586 Riga (Latvia); Department of Chemistry, Moscow State University, GSP-2 Leninskie gory 1/3, Moscow RU-119992 (Russian Federation)

2010-04-15

190

A Phase I Trial of Samarium-153-Lexidronam Complex for Treatment of Clinically Nonmetastatic High-Risk Prostate Cancer: First Report of a Completed Study  

SciTech Connect

Purpose: We completed a Phase I trial to determine the maximum tolerated dose of samarium-153 EDTMP ({sup 153}Sm) with hormonal therapy (HT) and radiation therapy (RT) in high-risk clinically nonmetastatic prostate cancer. Methods and Materials: High-risk M0 prostate cancer patients (prostate-specific antigen >20 ng/mL, Gleason score >7, or >T3) were eligible for this prospective trial of dose-escalated radioactive {sup 153}Sm-EDTMP (.25-2.0 mCi/kg) as primary or postoperative therapy. After 1 month of HT, we administered {sup 153}Sm-EDTMP followed by 4 more months of HT, 46.8 Gy to the pelvic region and 23.4 Gy to the prostate target (TD = 70.2 Gy). The primary endpoint was Grade III toxicity or higher by the National Cancer Institute Common Toxicity Criteria. Results: Twenty-nine patients enrolled (median prostate-specific antigen = 8.2 ng/mL, 27/29 (93%) T stage {>=}T2b, 24/29 (83%) had Gleason >7) and received {sup 153}Sm-EDTMP (.25 mCi/kg, 4 patients; 0.5 mCi/kg, 4 patients; 0.75 mCi/kg, 6 patients; 1.0 mCi/kg, 6 patients; 1.5 mCi/kg, 5 patients; 2.0mCi/kg, 4 patients). Twenty-eight patients underwent all planned therapy without delays (1 patient required surgery before the start of RT). With a median follow-up time of 23 months, there were 2 patients (7 %) experiencing Grade III hematologic toxicity. There were no other Grade III or IV side effects. Conclusions: Our trial demonstrates that 2 mCi/kg {sup 153}Sm -EDTMP with HT and RT was safe and feasible in men with high-risk M0 prostate cancer. A Phase II study to test this treatment is currently underway by the Radiation Therapy Oncology Group.

Valicenti, Richard K., E-mail: richard.valicenti@ucdmc.ucdavis.ed [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Trabulsi, Edouard [Department of Urology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Intenzo, Charles [Department of Radiology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Lavarino, Jorosali [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Xu Yihuan; Chervoneva, Inna [Department of Pharmacology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States)

2011-03-01

191

Multimodal treatment of pain.  

PubMed

Chronic pain is a complex disorder with extensive overlap in sensory and limbic pathways. It needs systemic therapy in addition to focused local treatment. This article discusses treatment modalities other than surgical and interventional approaches and also discusses the literature regarding these treatment modalities, including pharmacotherapy, physical and occupational therapy, psychological approaches including cognitive behavior therapy, and other adjunctive treatments like yoga and tai chi. PMID:25240667

Mathews, Manu

2014-10-01

192

Complexity International  

NSDL National Science Digital Library

Complexity International (CI) is an electronic journal devoted to "the field of complex systems, the generation of complex behaviour from the interaction of multiple parallel processes." The journal covers a wide variety of topics, including genetic algorithms, neural networks, and chaos theory. Because much of the focus is based on technological imitation of biological processes, some of the papers are closely tied to the life sciences. Volumes are added to on a continual basis as papers are accepted. Due to the lengthy acceptance process, it is especially useful that the CI Web site offers drafts of current submissions.

193

Improved Prevention, Screening & Treatment  

Cancer.gov

Cancers develop through a complex interplay between genetic and environmental factors. By identifying and understanding this process, we can often develop preventive interventions or use tailored screening and treatment approaches for individuals at increased risk of developing cancer.

194

Packaged Waste Treatment  

NASA Technical Reports Server (NTRS)

This Jacksonville, Florida, apartment complex has a wastewater treatment system which clears the water, removes harmful microorganisms and reduces solid residue to ash. It is a spinoff from spacecraft waste management and environmental control technology.

1977-01-01

195

KNOWLEDGE COMPLEXITY VERSUS COMPUTATIONAL COMPLEXITY  

E-print Network

, and Rafi Ostrovsky, with whom I had the opportunity to work closely. Each of them contributed in his own to thank Mihir and Rafi for collaborating with us in the research of knowledge complexity versus

Goldreich, Oded

196

Complex regional pain syndrome  

Microsoft Academic Search

Opinion statement  Complex regional pain syndrome (CRPS) is a heterogeneous disorder that falls in the spectrum of neuropathic pain disorders.\\u000a It is maintained by abnormalities throughout the neuraxis (the peripheral, autonomic, and central nervous systems). The pathophysiology\\u000a of CRPS is not fully known. There are no scientifically well-established treatments. The diagnostic criteria for CRPS at this\\u000a time are purely clinical, and

Ok Yung Chung; Stephen P. Bruehl

2003-01-01

197

Management of Gingivobuccal Complex Cancer  

PubMed Central

INTRODUCTION Squamous cell carcinoma of the oral cavity ranks as the 12th most common cancer in the world and the 8th most frequent in males. It accounts for up to one-third of all tobacco-related cancers in India. Cancer of the gingivobuccal complex is especially common in Indians due to their tobacco habits. This review focuses on the management of lower gingivobuccal complex cancers. PATIENTS AND METHODS References for this review were identified by search of Medline and other bibliographic information available in the PubMed database. The search terms carcinoma oral cavity, and cancer oral cavity, buccal mucosa, gingiva, gingivobuccal complex, and alveolus cancer/carcinoma were used. References from relevant articles and abstracts from international conferences were also included. Only articles published in the English language were used. RESULTS Treatment of gingivobuccal complex cancer is primarily surgical. Radical neck dissection, or its modification, is the standard treatment for the node-positive neck. Supraomohyoid neck dissection is the accepted treatment for the node-negative neck. Radiotherapy is usually not the preferred modality of treatment for early gingivobuccal complex cancer. It is used either as postoperative adjuvant treatment or as definitive treatment for advanced cancer with or witihout chemotherapy. Chemotherapy has been used as neo-adjuvant, adjuvant or palliative treatment. Advanced cancers are common and continue to pose a challenge to the multidisciplinary team. CONCLUSIONS Gingivobuccal complex cancer remains a major public health problem despite being highly preventable and easily detectable. Advanced cancers constitute a major proportion of patients presenting for treatment. These patients are difficult to treat and have a poor outcome. PMID:18701010

Misra, Sanjeev; Chaturvedi, Arun; Misra, NC

2008-01-01

198

Complex Systems  

PubMed Central

Physiologic systems in health and disease display an extraordinary range of temporal behaviors and structural patterns that defy understanding based on linear constructs, reductionist strategies, and classical homeostasis. Application of concepts and computational tools derived from the contemporary study of complex systems, including nonlinear dynamics, fractals and “chaos theory,” is having an increasing impact on biology and medicine. This presentation provides a brief overview of an emerging area of biomedical research, including recent applications to cardiopulmonary medicine and chronic obstructive lung disease. PMID:16921107

Goldberger, Ary L.

2006-01-01

199

THE GYMNAST'S WRIST: ACQUIRED POSITIVE ULNAR VARIANCE FOLLOWING CHRONIC EPIPHYSEAL INJURY  

Microsoft Academic Search

Five cases of symptomatic acquired positive ulnar variance are described. All cases occurred due to premature physeal closure of the growth plate in teenage girl gymnasts. All cases demonstrated ulnocarpal impingement, for which we describe a clinical test.Arthroscopic assessment of the wrist allowed us to assess the integrity of the TFCC (triangular fibrocartilaginous complex) and decide on the most appropriate

A. R. TOLAT; P. L. SANDERSON; L. DE SMET; J. K. STANLEY

1992-01-01

200

A 'complex solution' to a 'complex' problem: tackling the complexity of cancer with botanicals.  

PubMed

Several biological and physical factors confer complexity on cancer, which may be responsible for its associated morbidity. The successful management of this hyperproliferative disease is beyond the realm of therapeutics that may include the use of a single or at times a combination of treatment modalities. It is apparent that prevention with complex agents such as botanicals could serve as a possible potential solution. The present review focuses on the aspects of cancer that contribute toward making it an extremely complex disease and that may be tackled effectively with the use of 'multicomponent' botanicals. PMID:24911998

Arora, Neha; Koul, Ashwani

2014-11-01

201

HPV Treatment  

MedlinePLUS

... Share Compartir Treatment Is there a treatment for HPV or related problems? There is no treatment for ... but there are treatments for the problems that HPV can cause: Visible genital warts may remain the ...

202

Hyperbaric treatment  

NASA Technical Reports Server (NTRS)

Viewgraphs on hyperbaric treatment are presented. Topics covered include: hyperbaric treatment - purpose; decompression sickness; sources of decompression sickness; physical description; forms of decompression sickness; hyperbaric treatment of decompression sickness; and duration of treatment.

Amoroso, Michael T.

1990-01-01

203

Treatment for ADHD: Is More Complex Treatment Cost-Effective for More Complex Cases?  

Microsoft Academic Search

Objective. To determine the cost-effectiveness of three alternative high-quality treat- ments for attention deficit hyperactivity disorder (ADHD) relative to community care (CC) and to determine whether cost-effectiveness varies with the presence of comorbid disorders. Data Sources\\/Collection. The study included 579 children ages 7-9.9 with diag- nosed ADHD at six sites. Data for the study were distilled from administrative data and

E. Michael Foster; Peter S. Jensen; Michael Schlander; William E. Pelham Jr; Lily Hechtman; L. Eugene Arnold; James M. Swanson; Timothy Wigal

2007-01-01

204

After Treatment  

MedlinePLUS

Testicular Cancer Treatments: After Treatment One of the most common questions we hear on TC-NET is " My ... reported." Our recommendations are divided by type of testicular cancer, stage, and treatment given. Clinical Stage I Nonseminoma - ...

205

Glaucoma Treatments  

MedlinePLUS

... for Change Get Involved Research Grants Special Events Glaucoma Treatments In this section you will find information on current treatments for glaucoma, including drugs and laser and conventional surgery… Treatments ...

206

ICD Complex Operations and Maintenance Plan  

SciTech Connect

This Operations and Maintenance (O&M) Plan describes how the Idaho National Laboratory (INL) conducts operations, winterization, and startup of the Idaho CERCLA Disposal Facility (ICDF) Complex. The ICDF Complex is the centralized INL facility responsible for the receipt, storage, treatment (as necessary), and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) remediation waste.

Gibson, P. L.

2007-06-25

207

Pathomechanisms of ulnar ligament lesions of the wrist in a cadaveric distal radius fracture model  

PubMed Central

Background and purpose Mechanisms of injury to ulnar-sided ligaments (stabilizing the distal radioulnar joint and the ulna to the carpus) associated with dorsally displaced distal radius fractures are poorly described. We investigated the injury patterns in a human cadaver fracture model. Methods Fresh frozen human cadaver arms were used. A dorsal open-wedge osteotomy was performed in the distal radius. In 8 specimens, pressure was applied to the palm with the wrist in dorsiflexion and ulnar-sided stabilizing structures subsequently severed. Dorsal angulation was measured on digitized radiographs. In 8 other specimens, the triangular fibrocartilage complex (TFCC) was forced into rupture by axially loading the forearm with the wrist in dorsiflexion. The ulnar side was dissected and injuries were recorded. Results Intact ulnar soft tissues limited the dorsal angulation of the distal radius fragment to a median of 32o (16–34). A combination of bending and shearing of the distal radius fragment was needed to create TFCC injuries. Both palmar and dorsal injuries were observed simultaneously in 6 of 8 specimens. Interpretation A TFCC injury can be expected when dorsal angulation of a distal radius fracture exceeds 32o. The extensor carpi ulnaris subsheath may be a functionally integral part of the TFCC. Both dorsal and palmar structures can tear simultaneously. These findings may have implications for reconstruction of ulnar sided soft tissue injuries. PMID:21504313

2011-01-01

208

Dorsal Capsuloplasty for Dorsal Instability of the Distal Ulna  

PubMed Central

Background?Dorsal instability of the distal ulna can lead to chronic wrist pain and loss of function. Structural changes to the dorsal radioulnar ligaments (DRUL) of the triangular fibrocartilage complex (TFCC) and the dorsal capsule around the ulnar head with or without foveal detachment can lead to volar subluxation of the distal radius e.g., dorsal instability of the distal ulna. Purpose?Is to evaluate the post-operative results of reinstituting distal radioulnar joint (DRUJ) stability through reefing of the dorsal capsule and dorsal radioulnar ligaments, with and without a foveal reattachment of the TFCC. Methods?A total of 37 patients were included in this retrospective study. Diagnosis and treatment was based strictly on dry wrist arthroscopy. In 17 patients isolated reefing of the DRUL and their collateral tissue extension was performed. In 20 patients an additional foveal reinsertion was performed. Postoperative results were evaluated with the DASH questionnaire, VAS scores, grip strength and range of motion. These findings were extrapolated in the Mayo wrist score. The two subgroups were compared. Results?Mayo wrist scores of the whole population had a mean of 73. There was no difference between the group that was treated with reefing of the DRUL only and the group that was treated with a combined foveal reinsertion. Conclusion?This relatively simple 'dorsal reefing' procedure, with foveal reinsertion when indicated, is a reliable method to restore volar-dorsal DRUJ stability with a significant decrease in pain sensation, good DASH scores and restoration of functional grip strength and ROM. Type of Study/Level of Evidence?Therapeutic, Level IV. PMID:24436811

Kouwenhoven, S.T.P.; de Jong, T.; Koch, A.R.

2013-01-01

209

SCFA lead lab technical assistance at Oak Ridge Y-12 nationalsecurity complex: Evaluation of treatment and characterizationalternatives of mixed waste soil and debris at disposal area remedialaction DARA solids storage facility (SSF)  

SciTech Connect

On July 17-18, 2002, a technical assistance team from the U.S. Department of Energy (DOE) Subsurface Contaminants Focus Area (SCFA) met with the Bechtel Jacobs Company Disposal Area Remedial Action (DARA) environmental project leader to review treatment and characterization options for the baseline for the DARA Solids Storage Facility (SSF). The technical assistance request sought suggestions from SCFA's team of technical experts with experience and expertise in soil treatment and characterization to identify and evaluate (1) alternative treatment technologies for DARA soils and debris, and (2) options for analysis of organic constituents in soil with matrix interference. Based on the recommendations, the site may also require assistance in identifying and evaluating appropriate commercial vendors.

Hazen, Terry

2002-08-26

210

Complex Systems and Human Complexity in Medicine  

Microsoft Academic Search

Concepts taken from complex systems theory, such as ‘agents’ and ‘attractors’, have been proposed as metaphors in medical practice.This proposal is assessed by a comparison of the notions of complex adaptive systems (CAS) and human complexity. CAS are characterized by the emergence of sophisticated output features of rule-governed non-linear systems. Human complexity is the result of higher mental capacities and

Roger Strand; Guri Rortveit; Edvin Schei

2005-01-01

211

1. VIEW OF SEWAGE TREATMENT PLANT (BLDG. 769) SOUTH OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF SEWAGE TREATMENT PLANT (BLDG. 769) SOUTH OF STORAGE SHED (BLDG 773). SECURITY FENCE EAST OF SEWAGE TREATMENT PLANT. - Vandenberg Air Force Base, Space Launch Complex 3, Sewage Treatment Plant, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

212

The Mycobacterium avium complex.  

PubMed Central

Mycobacterium avium complex (MAC) disease emerged early in the epidemic of AIDS as one of the common opportunistic infections afflicting human immunodeficiency virus-infected patients. However, only over the past few years has a consensus developed about its significance to the morbidity and mortality of AIDS. M. avium was well known to mycobacteriologists decades before AIDS, and the MAC was known to cause disease, albeit uncommon, in humans and animals. The early interest in the MAC provided a basis for an explosion of studies over the past 10 years largely in response to the role of the MAC in AIDS opportunistic infection. Molecular techniques have been applied to the epidemiology of MAC disease as well as to a better understanding of the genetics of antimicrobial resistance. The interaction of the MAC with the immune system is complex, and putative MAC virulence factors appear to have a direct effect on the components of cellular immunity, including the regulation of cytokine expression and function. There now is compelling evidence that disseminated MAC disease in humans contributes to both a decrease in the quality of life and survival. Disseminated disease most commonly develops late in the course of AIDS as the CD4 cells are depleted below a critical threshold, but new therapies for prophylaxis and treatment offer considerable promise. These new therapeutic modalities are likely to be useful in the treatment of other forms of MAC disease in patients without AIDS. The laboratory diagnosis of MAC disease has focused on the detection of mycobacteria in the blood and tissues, and although the existing methods are largely adequate, there is need for improvement. Indeed, the successful treatment of MAC disease clearly will require an early and rapid detection of the MAC in clinical specimens long before the establishment of the characteristic overwhelming infection of bone marrow, liver, spleen, and other tissue. Also, a standard method of susceptibility testing is of increasing interest and importance as new effective antimicrobial agents are identified and evaluated. Antimicrobial resistance has already emerged as an important problem, and methods for circumventing resistance that use combination therapies are now being studied. Images PMID:8358707

Inderlied, C B; Kemper, C A; Bermudez, L E

1993-01-01

213

Water Treatment  

NSDL National Science Digital Library

Water treatment on a large scale enables the supply of clean drinking water to communities. In this activity, learners develop methods to clean a polluted water sample, describe components of a water treatment process, and learn how humans impact Earth's freshwater supply. The activity simulates methods used in real water treatment including aeration, coagulation, sedimentation, filtration and disinfection. This activity would be an excellent adjunct to a guided tour of a local water treatment plant.

Jersey, New; Center, Liberty S.; Coalition, New J.

2006-01-01

214

Therapeutic Doll Making in Art Psychotherapy for Complex Trauma  

ERIC Educational Resources Information Center

Therapeutic doll making can hold diverse functions for clients in therapy, particularly for those clients who are working through complex trauma histories. Recent literature pertaining to the treatment of complex trauma suggests that talking treatments have their limits; supplementary therapeutic approaches that focus on sensory, physical,…

Stace, Sonia M.

2014-01-01

215

Window treatments  

Microsoft Academic Search

This book includes basic material as well as information the professional needs for designing appropriate window treatments for residential and nonresidential buildings: site, orientation, climate, energy efficiency, sound-proofing, privacy, protection, view, ventilation and interior and exterior aesthetics. Also includes a guide to the window treatment industry, a list of manufacturers, distributors, and retailers, information on window treatment fibers and fabrics,

Nielson

1990-01-01

216

Complexes of clusters and complexes of stars  

E-print Network

Most star complexes are in fact complexes of stars, clusters and gas clouds; term "star complexes" was introduced as general one disregarding the preferential content of a complex. Generally the high rate of star formation in a complex is accompanied by the high number of bound clusters, including massive ones, what was explained by the high gas pressure in such regions. However, there are also complexes, where clusters seems to be more numerous in relation to stars than in a common complex. The high rate of clusters - but not isolated stars - formation seems to be typical for many isolated bursts of star formation, but deficit of stars might be still explained by the observational selection. The latter cannot, however, explain the complexes or the dwarf galaxies, where the high formation rate of only stars is observed. The possibility of the very fast dissolution of parental clusters just in such regions should itself be explained. Some difference in the physical conditions (turbulence parameters ?) within the initial gas supercloud might be a reason for the high or low stars/clusters number ratio in a complex.

Yu. N. Efremov

2005-12-12

217

Simplicial complexes Further ideas  

E-print Network

Graphs Simplicial complexes Further ideas Critical Groups of Simplicial Complexes Art Duval1, Martin Critical Groups of Simplicial Complexes #12;Graphs Simplicial complexes Further ideas Sandpiles and chip-firing Algebra Reduced Laplacian and spanning trees Sandpiles and chip-firing Motivation Think

Duval, Art

218

Complexity analysis of angiogenesis vasculature  

NASA Astrophysics Data System (ADS)

Tumor vasculature has a high degree of irregularity as compared to normal vasculature. The quantification of the morphometric complexity in tumor images can be useful in diagnosis. Also, it is desirable in several other medical applications to have an automated complexity analysis to aid in diagnosis and prognosis under treatment. e.g. in diabetic retinopathy and in arteriosclerosis. In addition, prior efforts at segmentation of the tumor vasculature using matched filtering, template matching and splines have been hampered by the irregularity of these vessels. We try to solve both problems by introducing a novel technique for vessel detection, followed by a tracing-independent complexity analysis based on a combination of ideas. First, the vessel cross-sectional profile is modeled using a continuous and everywhere differentiable family of super-Gaussian curves. This family generates rectangular profiles that can accurately localize the vessel boundaries in microvasculature images. Second, a robust non-linear regression algorithm based on M-estimators is used to estimate the parameters that optimally characterize the vessel"s shape. A framework for the quantitative analysis of the complexity of the vasculature based on the vessel detection is presented. A set of measures that quantify the complexity are proposed viz. Squared Error, Entropy-based and Minimum Description Length-based Shape Complexities. They are completely automatic and can deal with complexities of the entire vessel unlike existing tortuousity measures which deal only with vessel centerlines. The results are validated using carefully constructed phantom and real image data with ground truth information from an expert observer.

Mahadevan, Vijay; Tyrell, James A.; Tong, Ricky T.; Brown, Edward B.; Jain, Rakesh K.; Roysam, Badrinath

2005-04-01

219

Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5  

PubMed Central

Metabolic pathways play an indispensable role in supplying cellular systems with energy and molecular building blocks for growth, maintenance and repair and are tightly linked with lifespan and systems stability of cells. For optimal growth and survival cells rapidly adopt to environmental changes. Accumulation of acetic acid in stationary phase budding yeast cultures is considered to be a primary mechanism of chronological aging and induction of apoptosis in yeast, which has prompted us to investigate the dependence of acetic acid toxicity on extracellular conditions in a systematic manner. Using an automated computer controlled assay system, we investigated and model the dynamic interconnection of biomass yield- and growth rate-dependence on extracellular glucose concentration, pH conditions and acetic acid concentration. Our results show that toxic concentrations of acetic acid inhibit glucose consumption and reduce ethanol production. In absence of carbohydrates uptake, cells initiate synthesis of storage carbohydrates, trehalose and glycogen, and upregulate gluconeogenesis. Accumulation of trehalose and glycogen, and induction of gluconeogenesis depends on mitochondrial activity, investigated by depletion of the Hap2-3-4-5 complex. Analyzing the activity of glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), pyruvate kinase (PYK), and glucose-6-phosphate dehydrogenase (G6PDH) we found that while high acetic acid concentration increased their activity, lower acetic acids concentrations significantly inhibited these enzymes. With this study we determined growth and functional adjustment of metabolism to acetic acid accumulation in a complex range of extracellular conditions. Our results show that substantial acidification of the intracellular environment, resulting from accumulation of dissociated acetic acid in the cytosol, is required for acetic acid toxicity, which creates a state of energy deficiency and nutrient starvation. PMID:23050242

Kitanovic, Ana; Bonowski, Felix; Heigwer, Florian; Ruoff, Peter; Kitanovic, Igor; Ungewiss, Christin; Wolfl, Stefan

2012-01-01

220

Hyper Space Complex Number  

E-print Network

A new kind of numbers called Hyper Space Complex Numbers and its algebras are defined and proved. It is with good properties as the classic Complex Numbers, such as expressed in coordinates, triangular and exponent forms and following the associative and commutative laws of addition and multiplication. So the classic Complex Number is developed from in complex plane with two dimensions to in complex space with N dimensions and the number system is enlarged also.

Shanguang Tan

2007-03-23

221

The effects of infrared laser therapy and weightbath traction hydrotherapy as components of complex physical treatment in disorders of the lumbar spine: a controlled pilot study with follow-up  

NASA Astrophysics Data System (ADS)

Introduction: The therapeutic modalities available for the conservative management of chronic lumbar pain included infrared laser therapy and underwater traction, which usefulness is not universally acknowledged. This study was intended to ascertain any beneficial impact of infrared laser therapy and weightbath treatment on the clinical parameters and quality of life of patients with lumbar discopathy. Material and methods: The study population comprised 54 randomised subjects. I. group of 18 patents received only infrared laser therapy to lumbar region and painful Valley points. II. group of 18 subjects each received underwater traction therapy of lumbar spine with add-on McKenzie exercise and iontophoresis. The remaining III. group treated with exercise and iontophoresis, served as control. VAS, Oswestry index, SF36 scores, range of motion, neurological findings and thermography were monitored to appraise therapeutic afficacy in lumbar discopathy. A CT or MRI scan was done at baseline and after 3 months follow-up. Result:Infrared laser therapy and underwater traction for discopathy achieved significant improvement of all study parameters, which was evident 3 months later. Among the controls, significant improvement of only a single parameter was seen in patients with lumbar discopathy. Conclusions: Infrared laser therapy and underwater traction treatment effectively mitigate pain, muscle spasms, enhance joint flexibility, and improve the quality of life of patients with lumbar discopathy.

Oláh, Csaba; Oláh, Mihály; Demeter, Béla; Jancsó, Zoltán; Páll, Valéria; Bender, Tamás

2010-02-01

222

Simplifying complexity: a review of complexity theory  

Microsoft Academic Search

Complexity theory has captured the attention of the scientific community to the extent where its proponents tout it as a dominant scientific trend. Geographers, and environmental, human, and regional planners have applied complexity theory to topics ranging from cultural transmission and economic growth to the braiding of rivers. While such a wide array of applications is heartening because it speaks

Steven M. Manson

2001-01-01

223

Complexes of clusters and complexes of stars  

E-print Network

Most star complexes are in fact complexes of stars, clusters and gas clouds; term "star complexes" was introduced as general one disregarding the preferential content of a complex. Generally the high rate of star formation in a complex is accompanied by the high number of bound clusters, including massive ones, what was explained by the high gas pressure in such regions. However, there are also complexes, where clusters seems to be more numerous in relation to stars than in a common complex. The high rate of clusters - but not isolated stars - formation seems to be typical for many isolated bursts of star formation, but deficit of stars might be still explained by the observational selection. The latter cannot, however, explain the complexes or the dwarf galaxies, where the high formation rate of only stars is observed. The possibility of the very fast dissolution of parental clusters just in such regions should itself be explained. Some difference in the physical conditions (turbulence parameters ?) within t...

Efremov, Yu N

2005-01-01

224

Treatment goals: response and nonresponse  

PubMed Central

Psychiatric symptomatology is often subjective, but it can be partly made more objective for the purposes of evaluation. Esquirol was the first modern psychiatrist to stress the need for a scientific approach to treatment evaluation. The kinetics of treatment is complex because different components of the clinical picture improve at a different pace. Assessment of treatment requires prior definition of end point, response, and nonresponse. Response is influenced by several factors, such as placebo effect, diagnostic category and subtypes, and patient heterogeneity. Treatment response may be predicted from clinical and biological parameters. This article lists the main causes of nonresponse, and suggests how to remedy them. PMID:22034465

Macher, Jean-Paul; Crocq, Marc-Antoine

2004-01-01

225

Window treatments  

SciTech Connect

This book includes basic material as well as information the professional needs for designing appropriate window treatments for residential and nonresidential buildings: site, orientation, climate, energy efficiency, sound-proofing, privacy, protection, view, ventilation and interior and exterior aesthetics. Also includes a guide to the window treatment industry, a list of manufacturers, distributors, and retailers, information on window treatment fibers and fabrics, three glossaries, an extensive bibliography, and over 800 illustrations.

Nielson, K.J.

1990-01-01

226

Biomechanical analysis of the acetabular buttress-plate: are complex acetabular fractures in the quadrilateral area stable after treatment with anterior construct plate-1/3 tube buttress plate fixation?  

PubMed Central

OBJECTIVE: The acetabular buttress-plate has been widely used in treating difficult cases with satisfying clinical results. However, the biomechanical properties of a postoperative acetabular fracture fixed by the buttress-plate are not clear. The purpose of this study was to evaluate the biomechanical properties of stability after the anterior tube buttress-plate fixation of complex acetabular fractures in the quadrilateral area. METHODS: A construct was proposed based on anterior construct plate - 1/3 tube buttress plate fixation for acetabular both-column fractures. Two groups of six formalin-preserved cadaveric pelvises were analyzed: (1) group A, the normal pelvis and (2) group B, anterior construct plate-1/3 tube buttress plate with quadrilateral area fixation. The displacements were measured, and cyclical loads were applied in both standing and sitting simulations. RESULTS: As the load was added, the displacements were A

Wu, Yong-De; Cai, Xian-Hua; Liu, Xi-Ming; Zhang, Hong-Xi

2013-01-01

227

Wastewater Treatment  

NSDL National Science Digital Library

This lesson introduces students to the basics of wastewater treatment. Topics include the variety of materials that enter the wastewater system, septic tanks, and municpal treatment systems. Students can review online resources that describe the processes of wastewater treatment and septic tank operation in detail, and listen to a National Publc Radio (NPR) show that discusses the use of treated wastewater to make snow at a ski resort in Maine. The lesson includes an activity in which students participate in virtual tours of wastewater treatment facilities and answer questions about what they see.

Laposata, Mark

228

Simplicial Structure on Complexes.  

E-print Network

While chain complexes are equipped with a differential $d$ satisfying $d^2 = 0$, their generalizations called $N$-complexes have a differential $d$ satisfying $d^N = 0$. In this paper we show that the lax nerve of the category of chain complexes is pointwise adjoint equivalent to the décalage of the simplicial category of $N$-complexes. This reveals additional simplicial structure on the lax nerve of the category of chain complexes which provides a categorfication of the triangulated homotopy category of chain complexes. We study this phenomena in general and present evidence that the axioms of triangulated categories have simplicial origin.

Djalal Mirmohades

229

Development and psychometric validation of the HIV Treatment Knowledge Scale  

Microsoft Academic Search

Accurate treatment knowledge is required for patients to successfully manage complex medical conditions. Existing HIV knowledge scales focus on disease transmission and risk factors. This is the first study to develop and validate a scale to measure HIV treatment knowledge about complex treatment issues such as adherence, side-effects and drug resistance. A total of 346 participants were recruited into this

L. Balfour; J. Kowal; G. A. Tasca; C. L. Cooper; J. B. Angel; P. A. MacPherson; G. Garber; L. Béïque; D. W. Cameron

2007-01-01

230

Complex regional pain syndrome  

MedlinePLUS

Complex regional pain syndrome (CRPS) is a chronic pain condition that can affect any area of the ... Bailey A, Audette JF. Complex regional pain syndrome. In: Frontera ... of Physical Medicine and Rehabilitation. 2nd ed. Philadelphia, ...

231

Daunorubicin Lipid Complex Injection  

MedlinePLUS

Daunorubicin lipid complex is used to treat advanced Kaposi's sarcoma (a type of cancer that causes abnormal tissue to ... body) related to acquired immunodeficiency syndrome (AIDS). Daunorubicin lipid complex is in a class of medications called ...

232

Quantum Complex Minkowski Space  

E-print Network

The complex Minkowski phase space has the physical interpretation of the phase space of the scalar massive conformal particle. The aim of the paper is the construction and investigation of the quantum complex Minkowski space.

Grzegorz Jakimowicz; Anatol Odzijewicz

2005-05-06

233

Inference for two-stage adaptive treatment strategies using mixture distributions  

Microsoft Academic Search

Treatment of complex diseases such as cancer, leukaemia, acquired immune deficiency syndrome and depression usually follows complex treatment regimes consisting of time varying multiple courses of the same or different treatments. The goal is to achieve the largest overall benefit defined by a common end point such as survival. Adaptive treatment strategy refers to a sequence of treatments that are

Abdus S. Wahed

2010-01-01

234

Complex systems: An introduction  

Microsoft Academic Search

The characteristic feature of complex systems is the emergence of unexpected properties or behaviour. Complexity, beyond a certain threshold, may even lead to the emergence of new principles. It is\\u000a a one-way traffic: The new principles and features may be sometimes deducible from, but are not reducible to, those operating\\u000a at the lower levels of complexity. Reductionism stands discounted. Complexity

V. K. Wadhawan

2009-01-01

235

Conundrum of Combinatorial Complexity  

Microsoft Academic Search

This paper examines fundamental problems underlying difficulties encountered by pattern recognition algorithms, neural networks, and rule systems. These problems are manifested as combinatorial complexity of algorithms, of their computational or training requirements. The paper relates particular types of complexity problems to the roles of a priori knowledge and adaptive learning. Paradigms based on adaptive learning lead to the complexity of

Leonid I. Perlovsky

1998-01-01

236

Linguistic Complexity and Performance.  

ERIC Educational Resources Information Center

An experimental study investigating the interaction of linguistic complexity and performance in child language acquisition tests the hypothesis that children learning a first language acquire relatively complex sentences somewhat later than less complex sentences. In one of three tests, the subjects, 44 children aged 3.6 to 6 years, were presented…

Smith, Carlota S.; van Kleeck, Anne

237

Simply Complex by Design  

ERIC Educational Resources Information Center

Reality--real life--is complex, more complex than can be imagined. The majority of our most pressing issues confronted in the management of organizations are overwhelmingly complex. I make the case for a systems design approach as a remedy. Examples introduced in this paper illuminate conceptual tools that advance how people transform their…

Nelson, Harold G.

2007-01-01

238

Complex fuzzy soft multisets  

NASA Astrophysics Data System (ADS)

In this paper we combine two definitions, namely fuzzy soft multiset and complex fuzzy set to construct the definition of a complex fuzzy soft multiset and study its properties. In other words, we study the extension of a fuzzy soft multiset from real numbers to complex numbers. We also introduce its basic operations, namely complement, union and intersection. Some examples are given.

Alkouri, Abd Ulazeez M.; Salleh, Abdul Razak

2014-09-01

239

Analyse complexe Raymond Mortini  

E-print Network

Analyse complexe Raymond Mortini Universit´e Paul Verlaine - Metz Metz,22 d´ecembre 2013 R. Mortini () Analyse complexe Metz, 22 d´ecembre 2013 1 / 10 #12;Equations de Cauchy-Riemann Proposition Soit C un ouvert et f : C. R. Mortini () Analyse complexe Metz, 22 d´ecembre 2013 2 / 10 #12;Equations de Cauchy

Mortini, Raymond

240

Analyse complexe Raymond Mortini  

E-print Network

Analyse complexe Raymond Mortini Universit´e Paul Verlaine - Metz Metz,11 novembre 2013 R. Mortini () Analyse complexe Metz, 11 novembre 2013 1 / 1 #12;1 Limites et holomorphie A Notions basiques i2 = -1 R. Mortini () Analyse complexe Metz, 11 novembre 2013 2 / 1 #12;1 Limites et holomorphie A Notions basiques i

Mortini, Raymond

241

Minimal atomic complexes  

Microsoft Academic Search

We define minimal atomic complexes and irreducible complexes, and we prove that they are the same. The irreducible complexes admit homological characterizations that make them easy to recognize. These concepts apply both to spaces and to spectra. On the spectrum level, our characterizations allow us to show that such familiar spectra as ko, eo2, and BoP at the prime 2,

A. J. Baker; J. P. May

2004-01-01

242

Complex Correspondence Principle  

SciTech Connect

Quantum mechanics and classical mechanics are distinctly different theories, but the correspondence principle states that quantum particles behave classically in the limit of high quantum number. In recent years much research has been done on extending both quantum and classical mechanics into the complex domain. These complex extensions continue to exhibit a correspondence, and this correspondence becomes more pronounced in the complex domain. The association between complex quantum mechanics and complex classical mechanics is subtle and demonstrating this relationship requires the use of asymptotics beyond all orders.

Bender, Carl M.; Meisinger, Peter N. [Department of Physics, Washington University, St. Louis, Missouri 63130 (United States); Hook, Daniel W. [Theoretical Physics, Imperial College London, London SW7 2AZ (United Kingdom); Wang Qinghai [Department of Physics, National University of Singapore, Singapore 117542 (Singapore)

2010-02-12

243

Characterisation of alkane ?-complexes.  

PubMed

Alkane ?-complexes have evolved from a curious phenomenon to an intermediate of intense interest, fuelling research into the area. Over the last fifteen years, metal alkane complex characterisation has evolved to incorporate reports employing UV/Vis, IR and NMR spectroscopy, and X-ray and neutron diffractometry. Previously, due to the sparse geometric characterisation of alkane ?-complexes, assumptions regarding bonding geometries and selectivities were made by comparison to related ?-complexes, or by analysis of C-H activation products. This minireview assembles relevant literature that illuminates the metrics of alkane-metal bonding, and critically analyses the binding mode, selectivity and stability of alkane complexes. PMID:25196671

Young, Rowan D

2014-09-26

244

Eczema: Treatment  

MedlinePLUS

... more information on enabling JavaScript. Eczema Skip Content Marketing Share this: Main Content Area Treatment Content on ... as petroleum jelly. Moisturizers should be free of alcohol, scents, dyes, fragrances, and other skin-irritating chemicals. ...

245

Wastewater Treatment  

NSDL National Science Digital Library

Before this activity the students will have heard about groundwater and water resources through lecture to give them a background on where our drinking water comes from. The activity involves a tour of the local wastewater treatment plant where the students told about the treatment processes and shown the treatment facility. They are also introduced to the water quality testing done at the plans and they learn about the energy usage/management at the plant. As part of the activity they write up a paper on the processes in the treatment process from the time water enters the plant until it exits. The students are encouraged before hand to ask questions to ensure that they gather the needed information. This always means that each tour has a slightly different content based on these questions.

Pedersen, Bianca

246

Anthrax: Treatment  

MedlinePLUS

... Confirming Anthrax Through the Laboratory Response Network Laboratory Testing - FAQs Collecting Specimens Recommended Specimens Information for Specific Groups Laboratory Professionals People Who Work with Animal Products Exposure to Hides/Drums Treatment of Products ...

247

Systemic treatment.  

PubMed

In the last years the management of patients with liver cancer has been improved. The BCLC staging/treatment strategy identifies the optimal candidates for each treatment option and sorafenib is the only effective systemic treatment. Others (sunitinib, brivanib, linifanib, everolimus, ramucirumab) have failed in terms of safety/survival benefit. Some patients at intermediate/early stage, may be considered for systemic therapy when options of higher priority may have failed or not be feasible. The 800 mg/day is the recommended starting dose. Close follow-up and easy access for the patients so that they can report any adverse event and implement dose adjustments is the key point in the management of them. Development of early dermatologic adverse events has been correlated with better outcome and the pattern of radiologic progression characterizes better the prognosis/outcome of these patients. Treatment beyond progression may be considered if there is no option for a second line research trial. PMID:25260318

Reig, Maria; Gazzola, Alessia; Di Donato, Roberto; Bruix, Jordi

2014-10-01

248

Wastewater Treatment.  

ERIC Educational Resources Information Center

Presents the 1978 literature review of wastewater treatment. This review covers: (1) process application; (2) coagulation and solids separation; (3) adsorption; (4) ion exchange; (5) membrane processes; and (6) oxidation processes. A list of 123 references is also presented. (HM)

Zoltek, J., Jr.; Melear, E. L.

1978-01-01

249

Bench-to-bedside review: The evaluation of complex interventions in critical care  

Microsoft Academic Search

Complex interventions, such as the introduction of medical emergency teams or an early goal-directed therapy protocol, are developed from a number of components that may act both independently and inter-dependently. There is an emerging body of literature advocating the use of integrated complex interventions to optimise the treatment of critically ill patients. As with any other treatment, complex interventions should

Anthony Delaney; Derek C Angus; Rinaldo Bellomo; Peter Cameron; D James Cooper; Simon Finfer; David A Harrison; David T Huang; John A Myburgh; Sandra L Peake; Michael C Reade; Steve AR Webb; Donald M Yealy

2008-01-01

250

School Phobia: Understanding a Complex Behavioural Response  

ERIC Educational Resources Information Center

School phobia affects about 5% of the school-age population. If left untreated, school phobia can have devastating long-term consequences in children challenged by this condition. Various treatment approaches have been used to explore this complex behavioural response, major among them being the psychoanalytic, psychodynamic, pharmacological and…

Chitiyo, Morgan; Wheeler, John J.

2006-01-01

251

Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference  

PubMed Central

BACKGROUND Tuberous sclerosis complex is highly variable in clinical presentation and findings. Disease manifestations continue to develop over the lifetime of an affected individual. Accurate diagnosis is fundamental to implementation of appropriate medical surveillance and treatment. Although significant advances have been made in the past 15 years in the understanding and treatment of tuberous sclerosis complex, current clinical diagnostic criteria have not been critically evaluated or updated since the last clinical consensus conference in 1998. METHODS The 2012 International Tuberous Sclerosis Complex Consensus Group, comprising 79 specialists from 14 countries, was organized into 12 subcommittees, each led by a clinician with advanced expertise in tuberous sclerosis complex and the relevant medical subspecialty. Each subcommittee focused on a specific disease area with important diagnostic implications and was charged with reviewing prevalence and specificity of disease-associated clinical findings and their impact on suspecting and confirming the diagnosis of tuberous sclerosis complex. RESULTS Clinical features of tuberous sclerosis complex continue to be a principal means of diagnosis. Key changes compared with 1998 criteria are the new inclusion of genetic testing results and reducing diagnostic classes from three (possible, probable, and definite) to two (possible, definite). Additional minor changes to specific criterion were made for additional clarification and simplification. CONCLUSIONS The 2012 International Tuberous Sclerosis Complex Diagnostic Criteria provide current, updated means using best available evidence to establish diagnosis of tuberous sclerosis complex in affected individuals. PMID:24053982

Northrup, Hope; Krueger, Darcy A.

2014-01-01

252

Taurid meteor complex  

NASA Astrophysics Data System (ADS)

Structure of the autumnal part of the Taurid meteor complex based on photographic, radio and video meteor orbits is investigated and presented. Potential filaments or sub-streams to be associated with the complex were searched for utilizing the Southworth-Hawkins D-criterion. Altogether fourteen filaments or sub-streams associated with the complex were separated, with the length of the complex exceeding 100 degrees. Central part of the complex is formed by four the most dense filaments, the Northern and Southern Taurids, Southern Piscids and Omicron Orionids. The most probable bodies genetically related to the complex besides 2P/Encke are 2005 UY6, 2005 TF50 and 2007 RU17.

Bu?ek, M.; Porub?an, V.

2014-07-01

253

How evolution guides complexity.  

PubMed

Long-standing debates about the role of natural selection in the growth of biological complexity over geological time scales are difficult to resolve from the paleobiological record. Using an evolutionary model-a computational ecosystem subjected to natural selection-we investigate evolutionary trends in an information-theoretic measure of the complexity of the neural dynamics of artificial agents inhabiting the model. Our results suggest that evolution always guides complexity change, just not in a single direction. We also demonstrate that neural complexity correlates well with behavioral adaptation but only when complexity increases are achieved through natural selection (as opposed to increases generated randomly or optimized via a genetic algorithm). We conclude with a suggested research direction that might be able to use the artificial neural data generated in these experiments to determine which aspects of network structure give rise to evolutionarily meaningful neural complexity. PMID:20357890

Yaeger, Larry S

2009-10-01

254

How evolution guides complexity  

PubMed Central

Long-standing debates about the role of natural selection in the growth of biological complexity over geological time scales are difficult to resolve from the paleobiological record. Using an evolutionary model—a computational ecosystem subjected to natural selection—we investigate evolutionary trends in an information-theoretic measure of the complexity of the neural dynamics of artificial agents inhabiting the model. Our results suggest that evolution always guides complexity change, just not in a single direction. We also demonstrate that neural complexity correlates well with behavioral adaptation but only when complexity increases are achieved through natural selection (as opposed to increases generated randomly or optimized via a genetic algorithm). We conclude with a suggested research direction that might be able to use the artificial neural data generated in these experiments to determine which aspects of network structure give rise to evolutionarily meaningful neural complexity. PMID:20357890

Yaeger, Larry S.

2009-01-01

255

Complex Function Plot Program  

NSDL National Science Digital Library

The Complex Function Plot program displays a user-defined complex function of position and time using representations that map phase into color. The default complex function is a time-dependent complex Gaussian and the representation can be changed by selecting a radio button. Additional parameters can be specified using the Display | Switch GUI menu item. Complex Function Plot is an Open Source Physics program written for the teaching of mathematical methods in the sciences. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the math_complex_function_plot.jar file will run the program if Java is installed. Other mathematical methods programs are also available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Math.

Christian, Wolfgang

2008-05-14

256

Artistic forms and complexity.  

PubMed

We discuss the inter-relationship between various concepts of complexity by introducing a complexity 'triangle' featuring objective complexity, subjective complexity and social complexity. Their connections are explored using visual and musical compositions of art. As examples, we quantify the complexity embedded within the paintings of the Jackson Pollock and the musical works of Johann Sebastian Bach. We discuss the challenges inherent in comparisons of the spatial patterns created by Pollock and the sonic patterns created by Bach, including the differing roles that time plays in these investigations. Our results draw attention to some common intriguing characteristics suggesting 'universality' and conjecturing that the fractal nature of art might have an intrinsic value of more general significance. PMID:21382264

Boon, J-P; Casti, J; Taylor, R P

2011-04-01

257

Hypergraph coloring complexes  

PubMed Central

The aim of this paper is to generalize the notion of the coloring complex of a graph to hypergraphs. We present three different interpretations of those complexes–a purely combinatorial one and two geometric ones. It is shown, that most of the properties, which are known to be true for coloring complexes of graphs, break down in this more general setting, e.g., Cohen–Macaulayness and partitionability. Nevertheless, we are able to provide bounds for the f- and h-vectors of those complexes which yield new bounds on chromatic polynomials of hypergraphs. Moreover, though it is proven that the coloring complex of a hypergraph has a wedge decomposition, we provide an example showing that in general this decomposition is not homotopy equivalent to a wedge of spheres. In addition, we can completely characterize those hypergraphs whose coloring complex is connected. PMID:23483700

Breuer, Felix; Dall, Aaron; Kubitzke, Martina

2012-01-01

258

Child health in complex emergencies.  

PubMed Central

Coordinated and effective interventions are critical for relief efforts to be successful in addressing the health needs of children in situations of armed conflict, population displacement, and/or food insecurity. We reviewed published literature and surveyed international relief organizations engaged in child health activities in complex emergencies. Our aim was to identify research needs and improve guidelines for the care of children. Much of the literature details the burden of disease and the causes of morbidity and mortality; few interventional studies have been published. Surveys of international relief organizations showed that most use World Health Organization (WHO), United Nations Children's Fund (UNICEF), and ministry of health guidelines designed for use in stable situations. Organizations were least likely to have formal guidelines on the management of asphyxia, prematurity, and infection in neonates; diagnosis and management of children with human immunodeficiency virus (HIV) infection; active case-finding and treatment of tuberculosis; paediatric trauma; and the diagnosis and management of mental-health problems in children. Guidelines often are not adapted to the different types of health-care workers who provide care in complex emergencies. Evidence-based, locally adapted guidelines for the care of children in complex emergencies should be adopted by ministries of health, supported by WHO and UNICEF, and disseminated to international relief organizations to ensure appropriate, effective, and uniform care. PMID:16501716

Moss, William J.; Ramakrishnan, Meenakshi; Storms, Dory; Henderson Siegle, Anne; Weiss, William M.; Lejnev, Ivan; Muhe, Lulu

2006-01-01

259

Quantum Computational Complexity  

E-print Network

This article surveys quantum computational complexity, with a focus on three fundamental notions: polynomial-time quantum computations, the efficient verification of quantum proofs, and quantum interactive proof systems. Properties of quantum complexity classes based on these notions, such as BQP, QMA, and QIP, are presented. Other topics in quantum complexity, including quantum advice, space-bounded quantum computation, and bounded-depth quantum circuits, are also discussed.

John Watrous

2008-04-21

260

Synchronization in Complex Networks  

Microsoft Academic Search

The study of complex systems pervades all of science, from cell biology to ecology, from computer science to meteorology.\\u000a A paradigm of a complex system is a network [1] where complexity may come from di.erent sources: topological structure, network\\u000a evolution, connection and node diversity, and\\/or dynamical evolution. Examples of networks include food webs [2, 3], electrical\\u000a power grids, cellular and

Ljupco Kocarev; Gábor Vattay

261

Acute Heart Failure Treatment  

PubMed Central

Dyspnea is the predominant symptom for patients with acute heart failure and initial treatment is largely directed towards the alleviation of this. Contrary to conventional belief, not all patients present with fluid overload and the approach to management is rapidly evolving from a solitary focus on diuresis to one that more accurately reflects the complex interplay of underlying cardiac dysfunction and acute precipitant. Effective treatment thus requires an understanding of divergent patient profiles and an appreciation of various therapeutic options for targeted patient stabilization. The key principle within this paradigm is directed management that aims to diminish the work of breathing through situation appropriate ventillatory support, volume reduction and hemodynamic improvement. With such an approach, clinicians can more efficiently address respiratory discomfort while reducing the likelihood of avoidable harm. PMID:24223323

Bellou, Abdel

2013-01-01

262

Treatment Implications  

PubMed Central

Developing pharmacotherapies to treat alcohol dependence and associated health problems traditionally has been based on gaining a better understanding of the neuroscience underlying alcohol-drinking behavior. To date, three medications have been approved for the treatment of alcohol dependence: disulfiram (Antabuse®), naltrexone (Revia®, Vivitrol®, and Naltrel®), and acamprosate (Campral®). However, these medications have modest efficacy, and there is a great need for newer medications that target different neurochemical systems and which could be used either as adjunctive treatments or to treat subpopulations of drinkers. Furthermore, it also is important to improve current treatment options by understanding and incorporating differences in how people with certain genes respond to medication (i.e., pharmacogenetic differences). PMID:23584013

Krishnan-Sarin, Suchitra; O'Malley, Stephanie; Krystal, John H.

2008-01-01

263

Sewage Treatment  

NASA Technical Reports Server (NTRS)

Stennis Space Center's aquaculture research program has led to an attractive wastewater treatment for private homes. The system consists of a septic tank or tanks for initial sewage processing and a natural secondary treatment facility for further processing of septic tanks' effluent, consisting of a narrow trench, which contains marsh plants and rocks, providing a place for microorganisms. Plants and microorganisms absorb and digest, thus cleansing partially processed wastewater. No odors are evident and cleaned effluent may be discharged into streams or drainage canals. The system is useful in rural areas, costs about $1,900, and requires less maintenance than mechanical systems.

1991-01-01

264

Complex Motor Learning in Four-Year-Olds  

ERIC Educational Resources Information Center

The effects of 4 months of gymnostic training upon complex and simple gross motor abilities and general cognitive and psychosocial functioning in 4-year-olds were compared with the effects of music training and no treatment. (WY)

Leithwood, K. A.; Fowler, W.

1971-01-01

265

Glenohumeral instability associated with Buford complex.  

PubMed

Buford complex is described as a normal anatomical variant of the anterosuperior part of the glenoid consisting of the absence of the anterosuperior labrum with the presence of a cord-like middle glenohumeral ligament. Traditionally, reattachment to the glenoid has been discouraged. We present a case of a Buford complex associated with glenohumeral instability. The patient was operated for recurrent instability without a preoperative diagnosis of Buford complex. The diagnosis was made during shoulder arthroscopy and reattachment to the glenoid was performed with a satisfactory outcome. Here, we discuss the relationship of the Buford complex with intraarticular pathology and the surgical treatment in cases when this variant is associated with instability. PMID:19629434

del Rey, Fernando Canillas; Vázquez, Diego García-Germán; López, Daniel Nieto

2009-12-01

266

Labile sulfide and sulfite in phytochelatin complexes  

SciTech Connect

Heavy metals such as cadmium induce tomato cell cultures to synthesize the metal binding polypeptides ({gamma}-Glu-Cys){sub 3} and ({gamma}-Glu-Cys){sub 4}-Gly (phytochelatins). Tomato cells selected for growth on normally lethal concentrations of CdCl{sub 2} synthesize higher quantities of these polypeptides. Cd{sup r} cells are not cross-resistant to other heavy metals, and recent work suggests that metal detoxification by these peptides may be Cd-specific. The occurrence of labile sulfur as a component of the metal complex raises questions concerning possible functions of phytochelatins besides that of Cd binding. The presence of acid-labile sulfide ion in phytochelatin complexes has been reported by several groups. We report the additional finding that labile sulfite is also present in these complexes and in higher amounts than sulfide. Sulfide and sulfite are both released from the metal binding complex by acidification or by treatment with EDTA.

Eannetta, N.T.; Steffens, J.C. (Cornell Univ., Ithaca, NY (USA))

1989-04-01

267

Atmospheric Plasma - A New Surface Treatment Technology for Cleaning PCBs  

Microsoft Academic Search

Low-pressure plasmas have been used for many years to surface clean and functionalize substrates prior to downstream converting operations, therefore the benefits of plasma treatment are well recognized: reduced degradation of surface morphology, higher treatment (dyne) levels, elimination of backside treatment, and extended life of treatment over time. However, the complexity, slow speed and high cost of these contained vacuum

Rory A. Wolf

268

Wastewater treatment  

SciTech Connect

The processes presently used for industrial wastewater treatment are shown. This article presents an overview of the wastewaters and the processes, and then describes each process in detail, explaining how it works, what it can accomplish, and how it should be applied. Costs are also discussed. The authors explain how a combination of wastewaters can be economically treated so as to meet effluent limits.

Eckenfelder, W.W.; Patoczka, J.; Watkin, A.T.

1985-09-02

269

Wastewater Treatment  

NSDL National Science Digital Library

Water-technology.net web site for the water industry contains links to many sites for detailed information on industrial and municipal wastewater treatment plants as well as water supply and transmission. Also find information on current news releases, expos, conferences and much more.

2008-10-13

270

Surface Treatment  

NASA Technical Reports Server (NTRS)

A simple surface treatment process is provided which offers a high performance surface for a variety of applications at low cost. This novel surface treatment, which is particularly useful for Ti-6Al-4V alloys, is achieved by forming oxides on the surface with a two-step chemical process and without mechanical abrasion. First, after solvent degreasing, sulfuric acid is used to generate a fresh titanium surface. Next, an alkaline perborate solution is used to form an oxide on the surface. This acid-followed-by-base treatment is cost effective and relatively safe to use in commercial applications. In addition, it is chromium-free, and has been successfully used with a sol-gel coating to afford a strong adhesive bond that exhibits excellent durability after the bonded specimens have been subjected to a harsh 72 hour water boil immersion. Phenylethynyl containing adhesives were used to evaluate this surface treatment with a novel coupling agent containing both trialkoxysilane and phenylethynyl groups. 8 Claims, 16 Drawing Sheets

Park, Cheol (Inventor); Lowther, Sharon E. (Inventor); St.Clair, Terry L. (Inventor)

2003-01-01

271

Complex systems: Network thinking  

Microsoft Academic Search

Like arti?cial intelligence in its earlier years, the ?eld of complex systems has received a lot of press in the last two decades, both positive and negative, breezily hyped and unjustly derogatory. As in the early years of AI, complex systems scientists have at times made promises and set up expectations that are hard for any young science to ful?ll.

Melanie Mitchell

2006-01-01

272

Minimum complexity density estimation  

Microsoft Academic Search

The authors introduce an index of resolvability that is proved to bound the rate of convergence of minimum complexity density estimators as well as the information-theoretic redundancy of the corresponding total description length. The results on the index of resolvability demonstrate the statistical effectiveness of the minimum description-length principle as a method of inference. The minimum complexity estimator converges to

Andrew R. Barron; Thomas M. Cover

1991-01-01

273

Bacterial formate hydrogenlyase complex  

PubMed Central

Under anaerobic conditions, Escherichia coli can carry out a mixed-acid fermentation that ultimately produces molecular hydrogen. The enzyme directly responsible for hydrogen production is the membrane-bound formate hydrogenlyase (FHL) complex, which links formate oxidation to proton reduction and has evolutionary links to Complex I, the NADH:quinone oxidoreductase. Although the genetics, maturation, and some biochemistry of FHL are understood, the protein complex has never been isolated in an intact form to allow biochemical analysis. In this work, genetic tools are reported that allow the facile isolation of FHL in a single chromatographic step. The core complex is shown to comprise HycE (a [NiFe] hydrogenase component termed Hyd-3), FdhF (the molybdenum-dependent formate dehydrogenase-H), and three iron-sulfur proteins: HycB, HycF, and HycG. A proportion of this core complex remains associated with HycC and HycD, which are polytopic integral membrane proteins believed to anchor the core complex to the cytoplasmic side of the membrane. As isolated, the FHL complex retains formate hydrogenlyase activity in vitro. Protein film electrochemistry experiments on Hyd-3 demonstrate that it has a unique ability among [NiFe] hydrogenases to catalyze production of H2 even at high partial pressures of H2. Understanding and harnessing the activity of the FHL complex is critical to advancing future biohydrogen research efforts. PMID:25157147

McDowall, Jennifer S.; Murphy, Bonnie J.; Haumann, Michael; Palmer, Tracy; Armstrong, Fraser A.; Sargent, Frank

2014-01-01

274

Complex systems and valuation  

Microsoft Academic Search

Ecological and economic systems are undeniably complex. Whereas a goal of delineating ‘ecosystem services’ is to make readily apparent some of the important ways in which ecosystems underpin human welfare, insights are also gained by appreciating the nonlinear dynamic properties of ecosystems. In this paper, we review some of the relevant characteristics of complex systems. Ecosystems and economic systems share

Karin E. Limburg; Robert V. O'neill; Robert Costanza; Stephen Farber

2002-01-01

275

Complexity and Relations  

ERIC Educational Resources Information Center

A central feature of complexity is that it is based on non-linear, recursive relations. However, in most current accounts of complexity such relations, while non-linear, are based on the reductive relations of a Newtonian onto-epistemological framework. This means that the systems that are emergent from the workings of such relations are a…

Lancaster, Jeanette Elizabeth

2013-01-01

276

Immunization of complex networks  

Microsoft Academic Search

Complex networks such as the sexual partnership web or the Internet often show a high degree of redundancy and heterogeneity in their connectivity properties. This peculiar connectivity provides an ideal environment for the spreading of infective agents. Here we show that the random uniform immunization of individuals does not lead to the eradication of infections in all complex networks. Namely,

Romualdo Pastor-Satorras; Alessandro Vespignani

2002-01-01

277

Training in complex systems  

Microsoft Academic Search

Some people will talk of a new emerging Complexity Science, other ones will only refer to exploratory approaches to investigate complex systems. Beyond the words, we have to acknowledge that a set of new concepts and new tools have been developed by researchers from various disciplines to deal with interactions between multiple entities and processes rather than on isolated phenomena,

Edith Perrier

2010-01-01

278

[Pharmaceutical treatment of bipolar depression. Evidence from clinical guidelines and treatment recommendations].  

PubMed

Treatment of bipolar depression requires complex treatment decisions in daily routine care. The best evidence for pharmacological treatment is given for quetiapine and with limitations also in off-label use for lamotrigine, especially in combination with lithium, carbamazepine and olanzapine. Effectiveness and recommendation of antidepressants in treatment of bipolar depression remain controversial because of insufficient data. Initially, in depressive episodes a phase prophylactic treatment should be initiated or (if already existing) optimized and more severe episodes should be treated with the substances described before. In case of non-response, the combination of lithium and lamotrigine or antidepressants in combination with lithium, antiepileptics or atypical antipsychotics may be necessary. If depressive episodes occur in the course of pharmacological treatment with prophylactic agents, combination therapies of different substances, even with antidepressants, are necessary. In case of treatment-resistant depressive episodes, complex treatment strategies (e.g. combination therapies and MAO inhibitors) should be considered. PMID:24170252

Köhler, S; Bauer, M; Bschor, T

2014-09-01

279

[Omaron in the complex treatment of patients with multiple sclerosis].  

PubMed

We studied efficacy and tolerability of the combined drug omaron (25 mg of cinnarizine and 400 mg of piracetam in one tablet) in patients with multiple sclerosis. The dosage of the drug was 1 tablet 3 times a day during 12 weeks in 33 patients (mean age 35.3±4.2 years) of the index group. A comparison group consisted of 27 patients matched for demographic and clinical characteristics who did not receive nootropics during the study. None of patients included in the study received disease modifying drugs. The significant (p<0.05) decrease in the severity of chronic fatigue syndrome (by 28.6% compared to baseline), improvement (p<0.05) of cognitive functions (increase of MMSE scores by 9.4%) were found in the index group compared to the comparison one. The statistically significant changes in the severity of disability assessed by EDSS were not observed. Omaron was well-tolerated with no serious adverse-effects. PMID:21183917

Popova, N F; Kamchatnov, P R; Riabukhina, O V; Batysheva, T T; Za?tsev, K A; Bo?ko, A N

2010-01-01

280

Optimising hydraulic fracture treatments in reservoirs under complex conditions.  

E-print Network

??Growing global energy demand has prompted the exploitation of non-conventional resources such as Coal Bed Methane (CBM) and conventional resources such as gas-condensate reservoirs. Exploitation… (more)

Valencia, Karen Joy

2005-01-01

281

Selenophene transition metal complexes  

SciTech Connect

This research shows that selenophene transition metal complexes have a chemistry that is similar to their thiophene analogs. Selenophene coordination has been demonstrated and confirmed by molecular structure in both the {eta}{sup 5}- and the {eta}{sup 1}(Se)-coordination modes. The reaction chemistry of selenophene complexes closely resembles that of the analogous thiophene complexes. One major difference, however, is that selenophene is a better donor ligand than thiophene making the selenophene complexes more stable than the corresponding thiophene complexes. The {sup 77}Se NMR chemical shift values for selenophene complexes fall within distinct regions primarily depending on the coordination mode of the selenophene ligand. In the final paper, the C-H bond activation of {eta}{sup 1}(S)-bound thiophenes, {eta}{sup 1}(S)-benzothiophene and {eta}{sup 1}(Se)-bound selenophenes has been demonstrated. The deprotonation and rearrangement of the {eta}{sup 1}(E)-bound ligand to the carbon bound L-yl complex readily occurs in the presence of base. Reprotonation with a strong acid gives a carbene complex that is unreactive towards nucleophilic attack at the carbene carbon and is stable towards exposure to air. The molecular structure of [Cp(NO)(PPh{sub 3})Re(2-benzothioenylcarbene)]O{sub 3}SCF{sub 3} was determined and contains a Re-C bond with substantial double bond character. Methyl substitution for the thienylcarbene or selenylcarbene gives a carbene that rearranges thermally to give back the {eta}{sup 1}(E)-bound complex. Based on these model reactions, a new mechanism for the H/D exchange of thiophene over the hydrodesulfurization catalyst has been proposed.

White, C.J.

1994-07-27

282

Antimicrobials Treatment  

NASA Astrophysics Data System (ADS)

The use of antimicrobials is a common practice for preservation of foods. Incorporation, in a food recipe, of chemical antimicrobials towards inhibition of spoilage and pathogenic micro-organisms results in the compositional modification of food. This treatment is nowadays undesirable for the consumer, who likes natural products. Scientific community reflecting consumers demand for natural antimicrobials has made efforts to investigate the possibility to use natural antimicrobials such us bacteriocins and essential oils of plant origin to inhibit microbial growth.

Drosinos, Eleftherios H.; Skandamis, Panagiotis N.; Mataragas, Marios

283

Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment.  

PubMed

We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N']copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in tumour cells by targeting mitochondria. In the present study, we found that p38(MAPK) (p38 mitogen-activated protein kinase) is the molecular link in the phosphorylation cascade connecting AMPK to p53. Transfection of SH-SY5Y cells with a dominant-negative mutant of AMPK resulted in a decrease in apoptosis and a significant reduction in phospho-active p38(MAPK) and p53. Similarly, reverse genetics of p38(MAPK) yielded a reduction in p53 and a decrease in the extent of apoptosis, confirming an exclusive hierarchy of activation that proceeds via AMPK/p38(MAPK)/p53. Fuel supplies counteracted [Cu(isaepy)(2)]-induced apoptosis and AMPK/p38(MAPK)/p53 activation, with glucose being the most effective, suggesting a role for energetic imbalance in [Cu(isaepy)(2)] toxicity. Co-administration of 3BrPA (3-bromopyruvate), a well-known inhibitor of glycolysis, and succinate dehydrogenase, enhanced apoptosis and AMPK/p38(MAPK)/p53 signalling pathway activation. Under these conditions, no toxic effect was observed in SOD (superoxide dismutase)-overexpressing SH-SY5Y cells or in PCNs (primary cortical neurons), which are, conversely, sensitized to the combined treatment with [Cu(isaepy)(2)] and 3BrPA only if grown in low-glucose medium or incubated with the glucose-6-phosphate dehydrogenase inhibitor dehydroepiandrosterone. Overall, the results suggest that NADPH deriving from the pentose phosphate pathway contributes to PCN resistance to [Cu(isaepy)(2)] toxicity and propose its employment in combination with 3BrPA as possible tool for cancer treatment. PMID:21548882

Filomeni, Giuseppe; Cardaci, Simone; Da Costa Ferreira, Ana Maria; Rotilio, Giuseppe; Ciriolo, Maria Rosa

2011-08-01

284

Complex intuitionistic fuzzy sets  

NASA Astrophysics Data System (ADS)

This paper presents a new concept of complex intuitionistic fuzzy set (CIFS) which is generalized from the innovative concept of a complex fuzzy set (CFS) by adding the non-membership term to the definition of CFS. The novelty of CIFS lies in its ability for membership and non-membership functions to achieve more range of values. The ranges of values are extended to the unit circle in complex plane for both membership and non-membership functions instead of [0, 1] as in the conventional intuitionistic fuzzy functions. We define basic operations namely complement, union, and intersection on CIFSs. Properties of these operations are derived.

Alkouri, Abdulazeez (Moh'd. Jumah) S.; Salleh, Abdul Razak

2012-09-01

285

Complexity and robustness  

PubMed Central

Highly optimized tolerance (HOT) was recently introduced as a conceptual framework to study fundamental aspects of complexity. HOT is motivated primarily by systems from biology and engineering and emphasizes, (i) highly structured, nongeneric, self-dissimilar internal configurations, and (ii) robust yet fragile external behavior. HOT claims these are the most important features of complexity and not accidents of evolution or artifices of engineering design but are inevitably intertwined and mutually reinforcing. In the spirit of this collection, our paper contrasts HOT with alternative perspectives on complexity, drawing on real-world examples and also model systems, particularly those from self-organized criticality. PMID:11875207

Carlson, J. M.; Doyle, John

2002-01-01

286

Mobile multiwave lidar complexes  

SciTech Connect

Multiwave mobile lidar complexes (MLCs) are designed and developed. A number of vehicle-based MLCs are built. The set of complex lidar probing data obtained with the help of MLCs is synchronised in space and time, covers a large area (the operation range of an MLC is 15 km), and is based on a unified methodological approach. The results of probing contain information on the concentration and physical nature of atmospheric aerosol, chemical composition of the gaseous phase of the atmosphere, wind and turbulence. The obtained data form the basis for a complex analysis of the ecological situation and prognosis of its development. (laser applications and other topics in quantum electronics)

Boreysho, A S; Konyaev, M A; Morozov, A V; Pikulik, A V; Savin, A V; Trilis, A V; Chakchir, S Ya [Institute of Laser Instruments and Technologies, D F Ustinov 'VOENMEKh' Baltic State Technical University, St Petersburg (Russian Federation); Boiko, N I; Vlasov, Yu N; Nikitaev, S P; Rozhnov, A V [Administration of the Commander of Radiation, Chemical and Biological Defence Corps of the Armed Forces of the Russian Federation (Russian Federation)

2005-12-31

287

Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks  

E-print Network

Detecting epistatic interactions plays a significant role in improving pathogenesis, prevention, diagnosis, and treatment of complex human diseases. Applying machine learning or statistical methods to epistatic interaction ...

Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

2012-12-17

288

STRUCTURAL BIOLOGY: Complex II Is Complex Too  

NSDL National Science Digital Library

Access to the article is free, however registration and sign-in are required. In aerobic eukaryotic cells, the respiratory chain of enzymes in the inner mitochondrial membrane transfers electrons from NADH and succinate to molecular oxygen, in the process producing the energy-rich molecule ATP. Hederstedt explains in his Perspective that the crystal structure of bacterial SQR (equivalent to mitochondrial complex II) reveals how the arrangement of redox centers in this enzyme enables electrons to be transferred to ubiquinone while minimizing production of reactive oxygen species that could damage tissues (Yankovskaya et al.).

Lars Hederstedt (Lund University;Department of Cell and Organism Biology)

2003-01-31

289

[Diagnosis and treatment of acute paraproctitis].  

PubMed

The results of treatment of 399 patients with various forms of acute paraproctitis are discussed. Comparative evaluation of therapeutic methods applied in the clinic is made. The authors suggest a complex method of treatment in which they use thermography with fluid crystals in topical diagnosis of abscesses of the pararectal fatty tissue and apply papain in combination with medium-frequency ultrasound for the treatment of perineal wounds. This method led to recovery of 97.4% of patients. PMID:7616699

Smirnov, V E; Lavreshin, P M; Vartanov, I E; Gobedzhishvili, V K

1995-01-01

290

Treatment of women who have undergone chemically induced abortions.  

PubMed

The pathophysiology of abortion induced by the transcervical introduction of compounds containing mixtures of soap, cresol and phenol is complex. A plan is necessary for the treatment of such critically ill women. The complex, multisystem damage produced by those compounds requires an extremely sophisticated treatment approach to avoid the many pitfalls that beset those cases. PMID:4045835

Burnhill, M S

1985-08-01

291

Complex Regional Pain Syndrome  

MedlinePLUS

Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. ... in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected ...

292

Complex Line Integrals I  

NSDL National Science Digital Library

Created by Lang More of the Connected Curriculum Project, the purpose of this module is to investigate the behavior of complex line integrals. This is one lesson within a much larger set of learning modules hosted by Duke University.

Moore, Lang

2010-06-21

293

Cell cycle: Complex evolution  

Microsoft Academic Search

Cell division is fundamental to life, and so might be expected to have changed little during evolution. Data from four species show that the genes involved can vary, but the regulation of complexes is a common theme.

Gavin Sherlock

2006-01-01

294

Complex navigation signal generator  

Microsoft Academic Search

Working design of the GNSS signal generator Xilinx Spartan 3MB platform — DA 12bit @ 125 MSPS Complex Air Navigation Geometry Simulator Simulated airplane movement Acquired and transformed real flight data GPS satellite movement model Signal parameters provided

Petr Bojda; Michal Dub

2011-01-01

295

Complex System Classification  

E-print Network

The use of terms such as “Engineering Systems”, “System of systems” and others have been coming into greater use over the past decade to denote systems of importance but with implied higher complexity than for the term ...

Magee, Christopher

2004-07-24

296

Complex Regional Pain Syndrome  

MedlinePLUS

... Syndrome? Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, ... Institute of Neurological Disorders and Stroke (NINDS). NINDS Chronic Pain Information Page Chronic pain information page compiled by ...

297

Pigment-protein complexes  

SciTech Connect

The photosynthetically-active pigment protein complexes of procaryotes and eucaryotes include chlorophyll proteins, carotenochlorophyll proteins, and biliproteins. They are either integral components or attached to photosynthetic membranes. Detergents are frequently required to solubilize the pigment-protein complexes. The membrane localization and detergent solubilization strongly suggest that the pigment-protein complexes are bound to the membranes by hydrophobic interactions. Hydrophobic interactions of proteins are characterized by an increase in entropy. Their bonding energy is directly related to temperature and ionic strength. Hydrophobic-interaction chromatography, a relatively new separation procedure, can furnish an important method for the purification of pigment-protein complexes. Phycobilisome purification and properties provide an example of the need to maintain hydrophobic interactions to preserve structure and function.

Siegelman, H W

1980-01-01

298

Flow of complex suspensionsa)  

NASA Astrophysics Data System (ADS)

The flow of complex suspensions is ubiquitous in nature and industrial applications. These suspensions are made of complex particles (anisotropic, deformable, or active) suspended in simple fluids. The macroscopic non-Newtonian properties of these suspensions depend on the nature of the suspended particles and their interaction with given flows. Here, we describe how one can make use of novel micro-fabrication techniques and microfluidic rheometers to determine their flow properties under well controlled experimental conditions. We discuss three different aspects important for the study of the flow of complex suspensions. First, we use a well known complex fluid to design a novel microfluidic rheometer. Then we measure the non-Newtonian shear viscosity of a dilute suspension of microswimmers adapting an existing microfluidic rheometer. And finally we use a micro-fabrication technique to produce well controlled model fibers inside microfluidic channels and give some examples of the flow dynamics when these model fiber suspensions are forced through constrictions.

Lindner, Anke

2014-10-01

299

The Psychopharmaceutical Complex  

Microsoft Academic Search

This chapter presents sociological critiques of biopsychiatry, including Beck’s critique in Risk Society. Interactions between drug companies, researchers, government agencies, and medical organizations are framed within Breggin’s\\u000a construct of the psychopharmaceutical complex. The construction of knowledge formed by the processes of the psychopharmaceutical complex implicates pharmaceutical companies\\u000a in the systematic promotion of drugs for a burgeoning number of psychiatric disorders,

Brian Kean

300

How evolution guides complexity  

Microsoft Academic Search

Long?standing debates about the role of natural selection in the growth of biological complexity over geological time scales are difficult to resolve from the paleobiological record. Using an evolutionary model—a computational ecosystem subjected to natural selection—we investigate evolutionary trends in an information?theoretic measure of the complexity of the neural dynamics of artificial agents inhabiting the model. Our results suggest that

Larry S. Yaeger

2009-01-01

301

Knitted Complex Networks  

Microsoft Academic Search

To a considerable extent, the continuing importance and popularity of complex\\u000anetworks as models of real-world structures has been motivated by scale free\\u000adegree distributions as well as the respectively implied hubs. Being related to\\u000asequential connections of edges in networks, paths represent another important,\\u000adual pattern of connectivity (or motif) in complex networks (e.g., paths are\\u000arelated to important

Luciano da Fontoura Costa

2007-01-01

302

Complex Networks and Graphs  

NSDL National Science Digital Library

Students learn about complex networks and how to represent them using graphs. They also learn that graph theory is a useful mathematical tool for studying complex networks in diverse applications of science and engineering, such as neural networks in the brain, biochemical reaction networks in cells, communication networks, such as the internet, and social networks. Topics covered include set theory, defining a graph, as well as defining the degree of a node and the degree distribution of a graph.

Complex Systems Science Laboratory

303

Complex/Symplectic Mirrors  

SciTech Connect

We construct a class of symplectic non-Kaehler and complex non-Kaehler string theory vacua, extending and providing evidence for an earlier suggestion by Polchinski and Strominger. The class admits a mirror pairing by construction. Comparing hints from a variety of sources, including ten-dimensional supergravity and KK reduction on SU(3)-structure manifolds, suggests a picture in which string theory extends Reid's fantasy to connect classes of both complex non-Kaehler and symplectic non-Kaehler manifolds.

Chuang, Wu-yen; Kachru, Shamit; /Stanford U., ITP /SLAC; Tomasiello, Alessandro; /Stanford U., ITP

2005-10-28

304

Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects.  

PubMed

Cross-sex hormone treatment is an important component in medical treatment of transsexual people. Endocrinologists are often faced with designing treatment recommendations. Although guidelines from organizations, such as the Harry Benjamin International Gender Dysphoria Association, have been helpful, management remains complex and experience guided. We discuss the range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment. Recommendations from seven clinical research centers treating transsexual people are discussed. In addition, self-reported hormonal regimens from 25 male-to-female transsexual people and five female-to-male transsexual people are reported. Finally, the potential adverse effects of cross-sex hormone treatment of transsexual people are reviewed. In light of the complexity of managing treatment goals and adverse effects, the active involvement of a medical doctor experienced in cross-sex hormonal therapy is vital to ensure the safety of transsexual people. PMID:12915619

Moore, Eva; Wisniewski, Amy; Dobs, Adrian

2003-08-01

305

Sewage Treatment  

NASA Technical Reports Server (NTRS)

In the early 1970's, National Space Technology Laboratories discovered that water hyacinths literally thrive on sewage; they absorb and digest nutrients and minerals from wastewater, converting sewage effluents to clean water. They offer a means of purifying water at a fraction of the cost of a conventional sewage treatment plant, and provide a bonus value in byproducts. Hyacinths must be harvested at intervals; the harvested plants are used as fertilizers, high-protein animal feed and a source of energy. Already serving a number of small towns, the "aquaculture" technique has significantly advanced with its adoption by a major U.S. city.

1984-01-01

306

[Novel Drugs for COPD Treatment].  

PubMed

Currently, numerous new compounds and inhaler types are reaching the market for the treatment of chronic obstructive pulmonary disease (COPD). They comprise new long-acting beta-2 agonists, muscarinic antagonists and inhaled corticosteroids. Most of them are for combination treatment in new fixed-dose inhalers. Even the combination of three components in one inhaler is under development. Thus, management of COPD are getting more differentiated but also much more complex. This review gives an overview of the state of art of pharmaceutical research in this area and offers a glimpse into the proximate future. PMID:25003907

Gillissen, A

2014-09-01

307

Pulling complexes out of complex diseases  

PubMed Central

Spinocerebellar ataxia 7 (SCA7) is an incurable disease caused by expansion of CAG trinucleotide sequences within the Ataxin-7 gene. This elongated CAG tract results in an Ataxin-7 protein bearing an expanded polyglutamine (PolyQ) repeat. SCA7 disease is characterized by progressive neural and retinal degeneration leading to ataxia and blindness. Evidence gathered from investigating SCA7 and other PolyQ diseases strongly suggest that misregulation of gene expression contributes to neurodegeneration. In fact, Ataxin-7 is a subunit of the essential Spt-Ada-Gcn5-Acetltransferase (SAGA) chromatin modifying complex that regulates expression of a large number of genes. Here we discuss recent insights into Ataxin-7 function and, considering these findings, propose a model for how polyglutamine expansion of Ataxin-7 may affect Ataxin-7 function to alter chromatin modifications and gene expression. PMID:25054097

Mohan, Ryan D; Abmayr, Susan M; Workman, Jerry L

2014-01-01

308

Cancer and bone: a complex complex.  

PubMed

Primary and secondary bone cancers are rare events. However, once settled, a complex process is started involving an extensive amount of factors and interactions. The bone micro-environment is a preferential site for (metastatic) tumor cells to enter, stay, colonize and expand. The fact that the tumor cells affect the complete bone environment involving many cell types and regulatory pathways to stimulate their own growth and escape from therapy is devastating for the patient. Many efforts have been made to get more insight into the mechanisms underlying the communication between bone cells and cancer cells and progress is made in therapeutic interventions. This review will discuss the biological mechanisms of primary bone malignancies (osteosarcoma, Ewing's sarcoma, chondrosarcoma, multiple myeloma) and secondary bone malignancies (bone metastases) and therapeutic interventions. PMID:25046842

van Driel, Marjolein; van Leeuwen, Johannes P T M

2014-11-01

309

BAF chromatin remodeling complex  

PubMed Central

The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size. PMID:23974113

Tuoc, Tran Cong; Narayanan, Ramanathan; Stoykova, Anastassia

2013-01-01

310

Controllability of Complex Networks  

NASA Astrophysics Data System (ADS)

The ultimate proof of our understanding of natural or technological systems is reflected in our ability to control them. While control theory offers mathematical tools to steer engineered systems towards a desired state, we lack a general framework to control complex self-organized systems, like the regulatory network of a cell or the Internet. Here we develop analytical tools to study the controllability of an arbitrary complex directed network, identifying the set of driver nodes whose time-dependent control can guide the system's dynamics. We apply these tools to real and model networks, finding that sparse inhomogeneous networks, which emerge in many real complex systems, are the most difficult to control. In contrast, dense and homogeneous networks can be controlled via a few driver nodes. Counterintuitively, we find that in both model and real systems the driver nodes tend to avoid the hubs. We show that the robustness of control to link failure is determined by a core percolation problem, helping us understand why many complex systems are relatively insensitive to link deletion. The developed approach offers a framework to address the controllability of an arbitrary network, representing a key step towards the eventual control of complex systems.

Liu, Yang; Slotine, Jean-Jacques; Barabasi, Albert-Laszlo

2011-03-01

311

Complexes and imagination.  

PubMed

Fantasies as imaginative activities are seen by Jung as expressions of psychic energy. In the various descriptions of active imagination the observation of the inner image and the dialogue with inner figures, if possible, are important. The model of symbol formation, as Jung describes it, can be experienced in doing active imagination. There is a correspondence between Jung's understanding of complexes and our imaginations: complexes develop a fantasy life. Complex episodes are narratives of difficult dysfunctional relationship episodes that have occurred repeatedly and are internalized with episodic memory. This means that the whole complex episode (the image for the child and the image for the aggressor, connected with emotions) is internalized and can get constellated in everyday relationship. Therefore inner dialogues do not necessarily qualify as active imaginations, often they are the expression of complex-episodes, very similar to fruitless soliloquies. If imaginations of this kind are repeated, new symbols and new possibilities of behaviour are not found. On the contrary, old patterns of behaviour and fantasies are perpetuated and become cemented. Imaginations of this kind need an intervention by the analyst. In clinical examples different kinds of imaginations are discussed. PMID:25331506

Kast, Verena

2014-11-01

312

Hydridomethyl iridium complex  

DOEpatents

A process for functionalizing methane comprising: (a) reacting methane with a hydridoalkyl metal complex of the formula: CpIr[P(R.sub.1).sub.3 ]H(R.sub.2) wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical having from 1 to 5 carbon atoms; Ir represents an iridium atom; P represents a phosphorus atom; R.sub.1 represents an alkyl group; R.sub.2 represents an alkyl group having at least two carbon atoms; and H represents a hydrogen atom, in the presence of a liquid alkane R.sub.3 H having at least three carbon atoms to form a hydridomethyl complex of the formula: CpIr[P(R.sub.1).sub.3 ]HMe where Me represents a methyl radical. (b) reacting said hydridomethyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas: CX'X"X'"X"" or CHX'X"X'"; wherein X', X", X"', and X"" represent halogens selected from bromine, iodine and chlorine, to halomethyl complex of step (a) having the formula: CpIr[P(R.sub.1).sub.3 ]MeX: (c) reacting said halomethyl complex with a mercuric halide of the formula HgX.sub.2 to form a methyl mercuric halide of the formula HgMeX; and (d) reacting said methyl mercuric halide with a molecular halogen of the formula X.sub.2 to form methyl halide.

Bergman, Robert G. (P.O. Box 7141, San Francisco, CA 94120-7141); Buchanan, J. Michael (P.O. Box 7141, San Francisco, CA 94120-7141); Stryker, Jeffrey M. (P.O. Box 7141, San Francisco, CA 94120-7141); Wax, Michael J. (P.O. Box 7141, San Francisco, CA 94120-7141)

1989-01-01

313

Surgical management of syringomyelia–Chiari complex  

Microsoft Academic Search

Great variety exists in the indications and techniques recommended for the surgical treatment of syringomyelia–Chiari complex.\\u000a More recently, magnetic resonance (MR) imaging has increased the frequency of diagnosis of this pathology and offered a unique\\u000a opportunity to visualize cavities inside the spinal cord as well as their relationship to the cranio-cervical junction. This\\u000a report presents 18 consecutive adult symptomatic syringomyelia

R. Ergün; G. Akdemir; A. R. Gezici; K. Tezel; E. Beskonakli; F. Ergüngör; Y. Taskin

2000-01-01

314

Treatment planning in molecular radiotherapy.  

PubMed

In molecular radiotherapy a radionuclide or a radioactively labelled pharmaceutical is administered to the patient. Treatment planning therefore comprises the determination of activity to administer. This administered activity should maximize tumour cell sterilization while minimizing normal tissue damage. In this work we present different approaches that are frequently used for determining the suitable activity. These approaches may be cohort- based as in chemotherapy, or patient-specific using dosimetry based on individual biokinetics. The approaches are different with respect to the input complexity, the corresponding costs and - in consequence - the quality of the therapy. In addition, a general scheme for data collection and analysis is proposed. To develop an effective and safe treatment, elaborate data need to be obtained. The main challenges, however, are collecting these complex data and analyse them properly. PMID:23597414

Glatting, Gerhard; Bardiès, Manuel; Lassmann, Michael

2013-12-01

315

MRSA (treatment)  

PubMed Central

Introduction Methicillin-resistant Staphylococcus aureus (MRSA) has a gene that makes it resistant to methicillin as well as to other beta lactam antibiotics including flucloxacillin, b-lactam/b-lactamase inhibitor combinations, cephalosporins, and carbapenems. MRSA can be part of the normal body flora (colonisation), especially in the nose, but can cause infection, especially in people with prolonged hospital admissions, with underlying disease, or after antibiotic use. About 40% of S aureus in blood cultures in the UK is resistant to methicillin. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatment for MRSA infections at any body site? What are the effects of treatment for MRSA nasal or extra-nasal colonisation? We searched: Medline, Embase, The Cochrane Library and other important databases up to July 2005 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 16 systematic reviews, RCTs, or observational studies that met our inclusion criteria. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiseptic body washes, chlorhexidine-neomycin nasal cream, clindamycin, daptomycin, fusidic acid, glycopeptides (teicoplanin, vancomycin), linezolid, macrolides (azithromycin, clarithromycin, erythromycin), mupirocin nasal ointment, quinolones (ciprofloxacin, levofloxacin, moxifloxacin), quinupristin-dalfopristin, rifampicin, systemic antimicrobials, tea tree preparations, tetracyclines (doxycycline, minocycline, oxytetracycline), trimethoprim, and trimethoprim-sulfamethoxazole.

2006-01-01

316

Complex Number Arithmetic Models  

NSDL National Science Digital Library

The four complex number arithmetic models in this item show the addition, subtraction, multiplication and division of a complex number z2 to all numbers z1 of a point grid. The z1 and z2 are changed and the grid is moved by dragging the tip of the z1 and z2 arrows in the z-plane. The parallelogram for the vector construction representing the arithmetic operation are drawn on the simulation's right-hand side. Complex Number Arithmetic models are part of âLearning and Teaching Mathematics using Simulations â Plus 2000 Examples from Physicsâ ISBN 978-3-11-025005-3, Walter de Gruyter GmbH & Co. KG

Roess, Dieter

2011-08-11

317

Synchronization in complex networks  

SciTech Connect

Synchronization processes in populations of locally interacting elements are in the focus of intense research in physical, biological, chemical, technological and social systems. The many efforts devoted to understand synchronization phenomena in natural systems take now advantage of the recent theory of complex networks. In this review, we report the advances in the comprehension of synchronization phenomena when oscillating elements are constrained to interact in a complex network topology. We also overview the new emergent features coming out from the interplay between the structure and the function of the underlying pattern of connections. Extensive numerical work as well as analytical approaches to the problem are presented. Finally, we review several applications of synchronization in complex networks to different disciplines: biological systems and neuroscience, engineering and computer science, and economy and social sciences.

Arenas, A.; Diaz-Guilera, A.; Moreno, Y.; Zhou, C.; Kurths, J.

2007-12-12

318

Alanine water complexes.  

PubMed

Two complexes of alanine with water, alanine-(H2O)n (n = 1,2), have been generated by laser ablation of the amino acid in a supersonic jet containing water vapor and characterized using Fourier transform microwave spectroscopy. In the observed complexes, water molecules bind to the carboxylic group of alanine acting as both proton donors and acceptors. In alanine-H2O, the water molecule establishes two intermolecular hydrogen bonds forming a six-membered cycle, while in alanine-(H2O)2 the two water molecules establish three hydrogen bonds forming an eight-membered ring. In both complexes, the amino acid moiety is in its neutral form and shows the conformation observed to be the most stable for the bare molecule. The microsolvation study of alanine-(H2O)n (n = 1,2) can be taken as a first step toward understanding bulk properties at a microscopic level. PMID:24617287

Vaquero, Vanesa; Sanz, M Eugenia; Peña, Isabel; Mata, Santiago; Cabezas, Carlos; López, Juan C; Alonso, José L

2014-04-10

319

Engineering complex tissues.  

PubMed

Tissue engineering has emerged at the intersection of numerous disciplines to meet a global clinical need for technologies to promote the regeneration of functional living tissues and organs. The complexity of many tissues and organs, coupled with confounding factors that may be associated with the injury or disease underlying the need for repair, is a challenge to traditional engineering approaches. Biomaterials, cells, and other factors are needed to design these constructs, but not all tissues are created equal. Flat tissues (skin); tubular structures (urethra); hollow, nontubular, viscus organs (vagina); and complex solid organs (liver) all present unique challenges in tissue engineering. This review highlights advances in tissue engineering technologies to enable regeneration of complex tissues and organs and to discuss how such innovative, engineered tissues can affect the clinic. PMID:23152327

Atala, Anthony; Kasper, F Kurtis; Mikos, Antonios G

2012-11-14

320

Knitted Complex Networks  

E-print Network

To a considerable extent, the continuing importance and popularity of complex networks as models of real-world structures has been motivated by scale free degree distributions as well as the respectively implied hubs. Being related to sequential connections of edges in networks, paths represent another important, dual pattern of connectivity (or motif) in complex networks (e.g., paths are related to important concepts such as betweeness centrality). The present work proposes a new supercategory of complex networks which are organized and/or constructed in terms of paths. Two specific network classes are proposed and characterized: (i) PA networks, obtained by star-path transforming Barabasi-Albert networks; and (ii) PN networks, built by performing progressive paths involving all nodes without repetition. Such new networks are important not only from their potential to provide theoretical insights, but also as putative models of real-world structures. The connectivity structure of these two models is investig...

Costa, Luciano da Fontoura

2007-01-01

321

Emergy and ecosystem complexity  

NASA Astrophysics Data System (ADS)

The question "What drives complexity?" is addressed in this paper. To answer this question, we explore the way energy and material resources of different quality flow through ecosystems and support, directly and indirectly, ecosystems growth and development. Processes of resource transformation throughout the ecosystem build order, cycle materials, generate and sustain information. Energy drives all these processes and energetic principles explain much of what is observed, including energy degradation according to the laws of thermodynamics. Emergy, a quantitative measure of the global environmental work supporting ecosystem dynamics, is used here in order to provide a deeper understanding of complexity growth and decline in ecosystems. Ecosystem complexity is discussed in this paper in relation to changes in structure, organization and functional capacity, as explained by changes in emergy, empower, and transformity.

Ulgiati, Sergio; Brown, Mark T.

2009-01-01

322

Exorcising the Exocyst Complex  

PubMed Central

The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated in tethering secretory vesicles to the plasma membrane. Originally identified two decades ago in budding yeast, investigations using several different eukaryotic systems have since made great progress toward determination of the overall structure and organization of the eight exocyst subunits. Studies point to a critical role for the complex as a spatiotemporal regulator through the numerous protein and lipid interactions of its subunits, although a molecular understanding of exocyst function has been challenging to elucidate. Recent progress demonstrates that the exocyst is also important for additional trafficking steps and cellular processes beyond exocytosis, with links to development and disease. In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways. PMID:22420621

Heider, Margaret R.; Munson, Mary

2012-01-01

323

Evaluation of treatments for myofascial pain syndrome and fibromyalgia  

Microsoft Academic Search

Myofascial pain syndrome (MPS) and fibromyalgia (FM) are complex conditions and pose significant challenges to clinicians\\u000a and patients. This chapter explores available treatments for MPS and FM in the context of pathophysiology, clinical evidence,\\u000a and experimental support. This information may prove to be helpful in designing individualized treatment for patients with\\u000a these complex syndromes. New treatments should be critically and

Nathan J. Rudin

2003-01-01

324

Luminescent macrocyclic lanthanide complexes  

DOEpatents

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

Raymond, Kenneth N. (Berkeley, CA); Corneillie, Todd M. (Campbell, CA); Xu, Jide (Berkeley, CA)

2012-05-08

325

Is Communication Complexity Physical?  

E-print Network

Recently, Brassard et. al. conjectured that the fact that the maximal possible correlations between two non-local parties are the quantum-mechanical ones is linked to a reasonable restriction on communication complexity. We provide further support for the conjecture in the multipartite case. We show that any multipartite communication complexity problem could be reduced to triviality, had Nature been more non-local than quantum-mechanics by a quite small gap for any number of parties. Intriguingly, the multipartite nonlocal-box that we use to show the result corresponds to the generalized Bell inequality that manifests maximal violation in respect to a local hidden-variable theory.

Samuel Marcovitch; Benni Reznik

2007-09-11

326

Planning Complex Projects Automatically  

NASA Technical Reports Server (NTRS)

Automated Manifest Planner (AMP) computer program applies combination of artificial-intelligence techniques to assist both expert and novice planners, reducing planning time by orders of magnitude. Gives planners flexibility to modify plans and constraints easily, without need for programming expertise. Developed specifically for planning space shuttle missions 5 to 10 years ahead, with modifications, applicable in general to planning other complex projects requiring scheduling of activities depending on other activities and/or timely allocation of resources. Adaptable to variety of complex scheduling problems in manufacturing, transportation, business, architecture, and construction.

Henke, Andrea L.; Stottler, Richard H.; Maher, Timothy P.

1995-01-01

327

ALMOST COMPLEX AND COMPLEX STRUCTURES ON REAL PROJECTIVE STIEFEL MANIFOLDS  

E-print Network

ALMOST COMPLEX AND COMPLEX STRUCTURES ON REAL PROJECTIVE STIEFEL MANIFOLDS J#19; ulius Korba#20 of the projective Stiefel man- ifolds admit almost complex structures compatible with their usual di#11;erentiable the results of Wang to show that many projective Stiefel manifolds admit complex structures. Our main results

Sankaran, Parameswaran

328

An insight into four orthodontic treatment need indices.  

PubMed

Occlusal indices have been introduced and used to rank or categorize the occlusion. According to Dr. William Shaw and colleagues (1995), there are five types of occlusal indices, diagnostic, epidemiologic, orthodontic treatment need, orthodontic treatment outcome, and treatment complexity indices. Orthodontic treatment need indices are used to rank the malocclusion. They were devised to minimize the subjectivity associated with the diagnosis, referral and complexity assessment of malocclusion. Some are also multifunctional and used to assess the outcome of orthodontic treatment. The overall aim of the present article is to provide an overview on four commonly used American and European orthodontic treatment need indices, review their modifications, advantages, and limitations. These indices are the Index of Orthodontic Treatment Need (IOTN), the Dental Aesthetic Index (DAI), the Handicapping Labio-Lingual Deviation index (HLD), and the Index of Complexity, Outcome and Need (ICON). PMID:22074838

Borzabadi-Farahani, Ali

2011-11-01

329

Swarm Intelligence Complex Systems  

E-print Network

Keywords Phylogeny Swarm Intelligence Complex Systems Parallel Computing » Prof. Dr. Martin Intelligence is a field of optimization that is inspired by the behaviour of natural swarms. The group. Phylogeny and Swarm Intelligence Contact Prof. Dr. Martin Middendorf Professur für Parallelverarbeitung und

Schüler, Axel

330

Complex lymphatic anomalies.  

PubMed

Complex lymphatic anomalies include several diagnoses with overlapping patterns of clinical symptoms, anatomic location, imaging features, hematologic alterations, and complications. Lymphatic malformations likely arise through anomalous embryogenesis of the lymphatic system. Analysis of clinical, imaging, histologic, and hematologic features is often needed to reach a diagnosis. Aspiration of fluid collections can readily define fluid as chylous or not. The presence of chyle indicates dysfunction at the mesenteric or retroperitoneal level or above the cisterna chyli due to reflux. The imaging patterns of generalized lymphatic anomaly (GLA) and Gorham-Stout disease have been segregated with distinctive bone lesions and peri-osseous features. More aggressive histology (spindled lymphatic endothelial cells), clinical progression, hemorrhage, or moderate hematologic changes should raise suspicion for kaposiform lymphangiomatosis. Biopsy may be needed for diagnosis, though avoidance of rib biopsy is advised to prevent iatrogenic chronic pleural effusion. Lymphangiography can visualize the anatomy and function of the lymphatic system and may identify dysfunction of the thoracic duct in central conducting lymphatic anomalies. Local control and symptom relief are targeted by resection, laser therapy, and sclerotherapy. Emerging data suggest a role for medical therapies for complications of complex lymphatic anomalies. Outcomes include recurrent effusion, infection, pain, fracture, mortality, and rarely, malignancy. Complex lymphatic anomalies present significant diagnostic and therapeutic challenges. Results from a phase 2 study of sirolimus in these and other conditions are expected in 2014. Improved characterization of natural history, predictors of poor outcomes, responses to therapy, and further clinical trials are needed for complex lymphatic anomalies. PMID:25241096

Trenor, Cameron C; Chaudry, Gulraiz

2014-08-01

331

Hydridomethyl iridium complex  

SciTech Connect

This patent describes a hydridomethyl complex of the formula: CpIr(P(R{sub 1}){sub 3})HMe. Cp represents a cyclopentadienyl or alkyl cyclopentadienyl radical; Ir represents an iridium atom; P represents a phosphorus atom; R{sub 1} represents an alkyl group; and Me represents a methyl group.

Bergman, R.G; Buchanan, J.M.; Stryker, J.M.; Wax, M.J.

1989-07-18

332

Complex Transcendental Functions  

NSDL National Science Digital Library

Created by Lang Moore for the Connected Curriculum Project, the purpose of this module is to provide an introduction to the elementary complex transcendental functions -- the exponential, sine, and cosine functions. This is one resource within a much larger set of learning modules hosted by Duke University.

Moore, Lang

2010-05-14

333

Quantum Complexity Theory  

Microsoft Academic Search

In this paper we study quantum computation from a complexity theoretic viewpoint. Our rst result is the existence of an ecien t universal quantum Turing machine in Deutsch's model of a quantum Turing machine (QTM) (Proc. Roy. Soc. London Ser. A, 400 (1985), pp. 97{117). This construction is substantially more complicated than the corresponding construction for classical Turing machines (TMs);

Ethan Bernstein; Umesh V. Vazirani

1997-01-01

334

Chiral de Rham Complex  

Microsoft Academic Search

:  We define natural sheaves of vertex algebras over smooth manifolds which may be regarded as semi-infinite de Rham complexes\\u000a of certain D-modules over the loop spaces. For Calabi–Yau manifolds they admit N=2 supersymmetry. Connection with Wakimoto modules is discussed.

Fyodor Malikov; Vadim Schechtman; Arkady Vaintrob

1999-01-01

335

Coordination Complexes of Cobalt.  

ERIC Educational Resources Information Center

Described is an experiment involving the synthesis and spectral studies of cobalt complexes that not only give general chemistry students an introduction to inorganic synthesis but allows them to conduct a systematic study on the effect of different ligands on absorption spectra. Background information, procedures, and experimental results are…

Williams, Gregory M.; And Others

1989-01-01

336

Remarks on Graph Complexity  

Microsoft Academic Search

We revisit the notion of graph complexity introduced by Pudlák, Rödl, and Savický [PRS]. Using their framework, we show that sufficiently strong superlinear monotone lower bounds for the very special class of 2-slice functions would imply superpolynomial lower bounds for some other functions. Given an n-vertex graph G, the corresponding 2-slice function f G on n variables evaluates to zero

Satyanarayana V. Lokam

337

CTR COMPLEX Performing Arts  

E-print Network

Cancer Center Benton Chapel Ingram Center for the Performing Arts A S A P Adult Emergency Barnes & Noble COMPLEX 50 NPHC FRATERNITIES 53C KAPPA ALPHA THETA 84 THE VANDERBILT CLINIC 130 JESUP PSYCHOLOGY 145 KECK 205B MEDICAL CHILD CARE 213 2135 BLAKEMORE 216 2146 BELCOURT 223 1207 17TH AVE 232 WESLEY PLACE

Simaan, Nabil

338

Tagging mammalian transcription complexity  

Microsoft Academic Search

The nature of the 'transcriptome' is more complex than first realized. Although CAGE, various tagging technol- ogies and tiling arrays show that most of the mammalian genome is transcribed, a large proportion of transcripts do not encode proteins and are either poorly polyade- nylated, involved in sense-antisense pairs or never leave the nucleus. In this article, I review the various

Piero Carninci

2006-01-01

339

Application of Surface Complexation  

E-print Network

.S. Nuclear Regulatory Commission Washington, DC 20555-0001 E-mail: DISTRIBUTION@nrc.gov Facsimile: 301B415B of Nuclear Regulatory Research NUREG/CR-6959 #12;Application of Surface Complexation Modeling to Selected Office of Nuclear Regulatory Research NUREG/CR-6959 #12;AVAILABILITY OF REFERENCE MATERIALS IN NRC

340

Complex Spatial Query Processing  

Microsoft Academic Search

The user of a Geographical Information System is not limited to conventional spatial selections and joins, but may also pose more complicated and descriptive queries. In this paper we focus on the efficient processing and optimization of complex spatial queries that involve combinations of spatial selections and joins. Our contribution is manifold; we first provide formulae that accurately estimate the

Nikos Mamoulis; Dimitris Papadias; Dinos Arkoumanis

2004-01-01

341

Restricting Grammatical Complexity  

ERIC Educational Resources Information Center

Theories of natural language syntax often characterize grammatical knowledge as a form of abstract computation. This paper argues that such a characterization is correct, and that fundamental properties of grammar can and should be understood in terms of restrictions on the complexity of possible grammatical computation, when defined in terms of…

Frank, Robert

2004-01-01

342

Emergy and ecosystem complexity  

Microsoft Academic Search

The question “What drives complexity?” is addressed in this paper. To answer this question, we explore the way energy and material resources of different quality flow through ecosystems and support, directly and indirectly, ecosystems growth and development. Processes of resource transformation throughout the ecosystem build order, cycle materials, generate and sustain information. Energy drives all these processes and energetic principles

Sergio Ulgiati; Mark T. Brown

2009-01-01

343

Complexity in Math  

NSDL National Science Digital Library

In this 7-minute video Ian Byrd offers suggestions for increasing the complexity of math problems in order to provide an appropriate challenge level for gifted students. When confronted with tasks in their Zone of Proximal Development, students are forced to develop strategies and skills that they can apply to more challenging work.

Byrd, Ian

2013-01-01

344

Synchronization in complex networks  

Microsoft Academic Search

Synchronization processes in populations of locally interacting elements are the focus of intense research in physical, biological, chemical, technological and social systems. The many efforts devoted to understanding synchronization phenomena in natural systems now take advantage of the recent theory of complex networks. In this review, we report the advances in the comprehension of synchronization phenomena when oscillating elements are

Alex Arenas; Albert Díaz-Guilera; Jurgen Kurths; Yamir Moreno; Changsong Zhou

2008-01-01

345

Complexity of network synchronization  

Microsoft Academic Search

The problem of simulating a synchronous network by an asynchronous network is investigated. A new simulation technique, referred to as a synchronizer, which is a new, simple methodology for designing efficient distributed algorithms in asynchronous networks, is proposed. The synchronizer exhibits a trade-off between its communication and time complexities, which is proved to be within a constant factor of the

Baruch Awerbuch

1985-01-01

346

Complex Digital Visual Systems  

ERIC Educational Resources Information Center

This article identifies possibilities for data visualization as art educational research practice. The author presents an analysis of the relationship between works of art and digital visual culture, employing aspects of network analysis drawn from the work of Barabási, Newman, and Watts (2006) and Castells (1994). Describing complex network…

Sweeny, Robert W.

2013-01-01

347

Climate: A Complex Interaction  

NSDL National Science Digital Library

This article continues an examination of each of the seven essential principles of climate literacy on which the online magazine Beyond Weather and the Water Cycle is structured. Principle 2 covers the complex interactions among the components of the Earth system. The author discusses the scientific concepts underlying the interactions and expands the discussion with diagrams, photos, and online resources.

Lightle, Kimberly

2011-03-01

348

Complex regional pain syndrome  

Microsoft Academic Search

Complex regional pain syndrome (CRPS) may develop after limb trauma and is characterized by pain, sensory-motor and autonomic symptoms. Most important for the understanding of the pathophysiology of CRPS are recent results of neurophysiological research. Major mechanism for CRPS symptoms, which might be present subsequently or in parallel during the course of CRPS, are trauma-related cytokine release, exaggerated neurogenic inflammation,

Frank Birklein; Neurologische Klinik

2005-01-01

349

Complexity in astroplasmas  

NASA Astrophysics Data System (ADS)

Ideas of complexity theory - including self-organized criticality - are being applied to the study of turbulence and astroplasmas in the solar system. An RAS MIST meeting in London brought together researchers from different disciplines to compare established paradigms with more recent ideas. Sandra Chapman, Mervyn Freeman and Sean Oughton report.

Chapman, Sandra; Freeman, Mervyn; Oughton, Sean

2001-04-01

350

[Experience of treatment of diabetic foot syndrome].  

PubMed

In The Clinic of Cathedra of The Catastrophes Medicine, Military Medicine, Anesthesiology and Reanimatology in 2010 - 2013 yrs 53 patients, ageing 23-65 yrs, were treated for diabetic foot syndrome (DFS) of neuropathic and mixed forms. Diagnostic-treatment algorithm was proposed for determination of level and degree of a circulation and neuropathic disorders, introduction of which have promoted optimization of surgical and local treatment, improvement of the complex treatment results in patients, suffering DFS. A new method of treatment application, using combined preparation of hyaluronic acid with the sodium succinic, have permitted to achieve a complete healing of the ulcer defect. PMID:25252415

Pertsov, V I; Ponomarenko, O V

2014-07-01

351

MRI-guided ablation of wide complex tachycardia in a univentricular heart  

PubMed Central

Magnetic resonance imaging can be used for preprocedural assessment of complex anatomy for radiofrequency (RF) ablations, e.g., in a univentricular heart. This case report features the treatment of a young patient with a functionally univentricular heart who suffered from persistent sudden onset tachycardia with wide complexes that required RF ablation as treatment. PMID:22953024

Reiter, Theresa; Ritter, Oliver; Nordbeck, Peter; Beer, Meinrad; Bauer, Wolfgang Rudolf

2012-01-01

352

Systematic and Evolutionary Studies in the Dichanthelium acuminatum (Poaceae:Paniceae) Complex  

E-print Network

by Hitchcock and Chase (1910). In this treatment Gould and Clark recognized eight varieties in the D. acuminatum complex: D. acuminatum vars. villosum, acuminatum, thurowii, implicatum, wrightianum, densiflorum, lindheimeri, and longiligulatum. Gould... by Hitchcock and Chase (1910). In this treatment Gould and Clark recognized eight varieties in the D. acuminatum complex: D. acuminatum vars. villosum, acuminatum, thurowii, implicatum, wrightianum, densiflorum, lindheimeri, and longiligulatum. Gould...

Hammer, Ricky Lee

2011-08-08

353

Comparison of conventional MRI and MR arthrography in the evaluation wrist ligament tears: A preliminary experience  

PubMed Central

Aims: To compare conventional magnetic resonance imaging (MRI) and direct magnetic resonance (MR) arthrography in the evaluation of triangular fibrocartilage complex (TFCC) and intrinsic wrist ligament tears. Materials and Methods: T1-weighted, fat suppressed (FS) proton density plus T2-weighted (FS PD/T2), 3D multiple-echo data image combination (MEDIC) sequences and direct MR arthrography were performed in 53 patients with wrist pain. Images were evaluated for the presence and location of TFCC, scapholunate ligament (SLL) and lunatotriquetral ligament (LTL) tears, and imaging findings were compared with operative findings in 16 patients who underwent arthroscopy or open surgery (gold standard). Results: Sixteen patients underwent arthroscopy/open surgery: 12 TFCC tears were detected arthroscopically out of which 9 were detected on FS PD/T2 sequence, 10 on MEDIC sequence, and all 12 were detected on MR arthrography. The sensitivities of FS PD/T2, MEDIC sequences, and MR arthrography in the detection of TFCC tears were 75%, 83.3%, and 100%, respectively. Out of the eight arthroscopically confirmed SLL tears, three tears were detected on FS PD/T2 sequence, five on MEDIC sequence, and all eight were visualized on MR arthrography. The sensitivities of FS PD/T2, MEDIC sequences, and MR arthrography in detecting SLL tears were 37.5%, 62.5%, and 100%, respectively. One arthroscopically confirmed LTL tear was diagnosed on FS PD/T2 sequence, three on MEDIC sequence, and all five arthroscopically confirmed LTL tears were detected with MR arthrography. The sensitivities of PD, MEDIC sequences, and MR arthrography in detecting LTL tears were 20%, 40%, and 100%, respectively. Conclusions: MR arthrography is the most sensitive and specific imaging modality for the evaluation of wrist ligament tears. PMID:25114389

Pahwa, Shivani; Srivastava, Deep N; Sharma, Raju; Gamanagatti, Shivanand; Kotwal, Prakash P; Sharma, Vijay

2014-01-01

354

ICDF Complex Remedial Action Work Plan  

SciTech Connect

This Remedial Action Work Plan provides the framework for operation of the Idaho Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Disposal Facility Complex (ICDF). This facility includes (a) an engineered landfill that meets the substantial requirements of DOE Order 435.1, Resource Conservation and Recovery Act Subtitle C, Idaho Hazardous Waste Management Act, and Toxic Substances Control Act polychlorinated biphenyl landfill requirements; (b) centralized receiving, inspections, administration, storage/staging, and treatment facilities necessary for CERCLA investigation-derived, remedial, and removal waste at the Idaho National Laboratory (INL) prior to final disposition in the disposal facility or shipment off-Site; and (c) an evaporation pond that has been designated as a corrective action management unit. The ICDF Complex, including a buffer zone, will cover approximately 40 acres, with a landfill disposal capacity of approximately 510,000 yd3. The ICDF Complex is designed and authorized to accept INL CERCLA-generated wastes, and includes the necessary subsystems and support facilities to provide a complete waste management system. This Remedial Action Work Plan presents the operational approach and requirements for the various components that are part of the ICDF Complex. Summaries of the remedial action work elements are presented herein, with supporting information and documents provided as appendixes to this work plan that contain specific detail about the operation of the ICDF Complex. This document presents the planned operational process based upon an evaluation of the remedial action requirements set forth in the Operable Unit 3-13 Final Record of Decision.

W. M. Heileson

2006-12-01

355

Non pharmacological treatments in fibromyalgia.  

PubMed

Fibromyalgia is a complex syndrome associated with significant impairment in quality of life and function and with substantial financial costs. Once the diagnosis is made, providers should aim to increase patients' function and minimize pain. Fibromyalgia patients frequently use alternative therapies, strongly indicating both their dissatisfaction with and the substantial ineffectiveness of traditional medical therapy, especially pharmacological treatments. At present, pharmacological treatments for fibromyalgia have a rather discouraging cost/benefit ratio in terms of poor symptom control and high incidence of side effects. The interdisciplinary treatment programs have been shown to improve subjective pain with greater success than monotherapy. Physical therapies, rehabilitation and alternative therapies are generally perceived to be more "natural," to have fewer adverse effects, and in some way, to be more effective. In this review, physical exercise and multimodal cognitive behavioural therapy are presented as the more accepted and beneficial forms of nonpharmacological therapy. PMID:18852909

Casale, R; Cazzola, M; Arioli, G; Gracely, R H; Ceccherelli, F; Atzeni, F; Stisi, S; Cassisi, G; Altomonte, L; Alciati, A; Leardini, G; Gorla, R; Marsico, A; Torta, R; Giamberardino, M A; Buskila, D; Spath, M; Marinangeli, F; Bazzichi, L; Di Franco, M; Biasi, G; Salaffi, F; Carignola, R; Sarzi-Puttini, P

2008-01-01

356

Complex Systems and Brain Sciences  

E-print Network

Center for Complex Systems and Brain Sciences Charles E. Schmidt College of Science www.ccs.fau.edu #12;Center for Complex Systems and Brain Sciences Our Mission The mission of the Center for Complex Systems and Brain Sciences is to understand the principles and mechanisms underlying complex behavior

Fernandez, Eduardo

357

Communication Complexity and Intrinsic Universality  

E-print Network

Communication Complexity and Intrinsic Universality in Cellular Automata E. Golesa , P.-E. Meunierc is to consider the communication complexity of various "canonical problems" related to the dynamics of F. We show complexity is maximal (P-complete, or 0 1-complete) while the corresponding communication complexity

Rapaport, Iván

358

Complexity in Biological Signaling Systems  

NSDL National Science Digital Library

Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.

Gezhi Weng (Mount Sinai School of Medicine;Department of Pharmacology); Upinder S. Bhalla (National Center for Biological Sciences;); Ravi Iyengar (Mount Sinai School of Medicine;Department of Pharmacology)

1999-04-02

359

A consistent modelling methodology for secondary settling tanks in wastewater treatment  

E-print Network

A consistent modelling methodology for secondary settling tanks in wastewater treatment Stefan on a consistent modelling methodology (CMM) of complex real processes in wastewater treatment by utilizing both as a case since this is one of the most complex processes in a wastewater treatment plant and the simulation

Bürger, Raimund

360

Visualizing Immune System Complexity  

NSDL National Science Digital Library

The European Molecular Biology Organization (EMBO) meeting "Visualizing Immune System Complexity," held in January 2009, covered multiple scales, from imaging single molecules to imaging whole animals. In addition to experimental details, there was an emphasis on modeling both for data analysis and as a predictive tool to support experimental design. Imaging technologies discussed included total internal reflection fluorescence microscopy, fluorescence correlation spectroscopy, two-photon laser scanning microscopy, and magnetic resonance imaging. The biological systems included basic aspects of adaptive and innate immunity. The type 1 diabetes model was used to illustrate how a human disease was dissected at all the scales, from single-molecule analysis of the interactions of T cell receptors with peptide-loaded major histocompatibility complexes to dynamics of immune cell infiltrates by intravital microscopy, as well as the application of imaging diagnostics in humans.

Michael L. Dustin (New York University;Skirball Institute of Biomolecular Medicine REV)

2009-04-14

361

A complex affair  

PubMed Central

Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrier. More recently, however, additional roles in signal transduction, differentiation and proliferation have been reported. Dysregulation is associated with a wide range of disease states, including diabetic retinopathy, irritable bowel disease and some cancers. ZO proteins and occludin form a protein complex that appears to act as a master regulator of TJ assembly/disassembly. Recent studies have highlighted the structural character of the primary ZO-1:occludin interaction and identified regions on occludin that control association and disassociation of TJ in a phosphorylation-dependent manner. We hypothesize that regions within ZO-1 in the so-called U5 and U6 regions behave in a similar manner. PMID:24665376

Bewley, Maria C.; Tash, Brian R.; Tian, Fang; Flanagan, John M.

2013-01-01

362

Compressively sensed complex networks.  

SciTech Connect

The aim of this project is to develop low dimension parametric (deterministic) models of complex networks, to use compressive sensing (CS) and multiscale analysis to do so and to exploit the structure of complex networks (some are self-similar under coarsening). CS provides a new way of sampling and reconstructing networks. The approach is based on multiresolution decomposition of the adjacency matrix and its efficient sampling. It requires preprocessing of the adjacency matrix to make it 'blocky' which is the biggest (combinatorial) algorithm challenge. Current CS reconstruction algorithm makes no use of the structure of a graph, its very general (and so not very efficient/customized). Other model-based CS techniques exist, but not yet adapted to networks. Obvious starting point for future work is to increase the efficiency of reconstruction.

Dunlavy, Daniel M.; Ray, Jaideep; Pinar, Ali

2010-07-01

363

NDT for Complex Projects  

NASA Astrophysics Data System (ADS)

Non-destructive testing of structures composed of various types of materials is performed using a variety of methods. Most commonly, electromagnetic and acoustic methods are used to perform this task. Advances in computer software and electro-mechanical hardware have resulted in semi-automated systems for performing simple low-cost in-situ concrete testing. These systems are designed to be operated by anyone who can read a manual and push the right buttons. Although useful in many circumstances, we ask: "What happens when concrete structures are not simple and are too complex to be analyzed by these semi-automated systems and, most importantly, by minimally trained operators?" Many infrastructure projects are boldly pushing the limit of traditional engineering design. As structures become more complex, the methods and techniques used to evaluate these structures must also evolve. A first step towards adapting geophysical methods to evaluate complex structures is to develop pre-investigation conceptual models of possible responses that structures will have to available geophysical methods. This approach is important for designing the geometry and data acquisition parameters necessary for achieving the desired results. Examples of case by case assessments of the application of GPR to concrete investigations are examined. These include complex concrete wall structures, soil tunnel structures, and airport runways. HGI's adaption of ground penetrating radar (GPR) and seismic methods for assessing the substrate of a heavily reinforced concrete structure up to seven feet thick is reviewed. A range of GPR antenna frequencies were used to image the concrete and the underlying material. Time and frequency domain GPR analyses where used in the assessment. A multi-channel seismic survey using a roll-along data collection technique was used to assess the resonant frequency of the concrete structure, the nature of the underlying medium, and behavior of the structural system.

Carnevale, Mario

2013-04-01

364

Photoreactivity of gold complexes  

Microsoft Academic Search

The light sensitivity of gold compounds has been known since 1737. More recent observations have led to a deeper understanding of the photochemistry of gold complexes, which are discussed on the basis of selected examples. Light sensitive Au(I) and Au(III) compounds are classified according to the nature of reactive excited states: metal-centered (MC), ligand-to-metal charge transfer (LMCT), metal-to-ligand charge transfer

Arnd Vogler; Horst Kunkely

2001-01-01

365

Verification of complex codes.  

SciTech Connect

Over the past several years, verifying and validating complex codes at Sandia National Laboratories has become a major part of code development. These aspects tackle two important parts of simulation modeling: determining if the models have been correctly implemented - verification, and determining if the correct models have been selected - validation. In this talk, we will focus on verification and discuss the basics of code verification and its application to a few codes and problems at Sandia.

Ober, Curtis Curry

2009-03-01

366

Complexity in Dynamical Systems  

NASA Astrophysics Data System (ADS)

The study of chaos has shown us that deterministic systems can have a kind of unpredictability, based on a limited knowledge of their initial conditions; after a finite time, the motion appears essentially random. This observation has inspired a general interest in the subject of unpredictability, and more generally, complexity; how can we characterize how "complex" a dynamical system is?. In this thesis, we attempt to answer this question with a paradigm of complexity that comes from computer science, we extract sets of symbol sequences, or languages, from a dynamical system using standard methods of symbolic dynamics; we then ask what kinds of grammars or automata are needed a generate these languages. This places them in the Chomsky heirarchy, which in turn tells us something about how subtle and complex the dynamical system's behavior is. This gives us insight into the question of unpredictability, since these automata can also be thought of as computers attempting to predict the system. In the culmination of the thesis, we find a class of smooth, two-dimensional maps which are equivalent to the highest class in the Chomsky heirarchy, the turning machine; they are capable of universal computation. Therefore, these systems possess a kind of unpredictability qualitatively different from the usual "chaos": even if the initial conditions are known exactly, questions about the system's long-term dynamics are undecidable. No algorithm exists to answer them. Although this kind of unpredictability has been discussed in the context of distributed, many-degree-of -freedom systems (for instance, cellular automata) we believe this is the first example of such phenomena in a smooth, finite-degree-of-freedom system.

Moore, Cristopher David

367

Processes on Complex Networks  

NSDL National Science Digital Library

Building on their understanding of graphs, students are introduced to random processes on networks. They walk through an illustrative example to see how a random process can be used to represent the spread of an infectious disease, such as the flu, on a social network of students. This demonstrates how scientists and engineers use mathematics to model and simulate random processes on complex networks. Topics covered include random processes and modeling disease spread, specifically the SIR (susceptible, infectious, resistant) model.

Complex Systems Science Laboratory

368

Engineering Complex Tissues  

PubMed Central

This article summarizes the views expressed at the third session of the workshop “Tissue Engineering—The Next Generation,” which was devoted to the engineering of complex tissue structures. Antonios Mikos described the engineering of complex oral and craniofacial tissues as a “guided interplay” between biomaterial scaffolds, growth factors, and local cell populations toward the restoration of the original architecture and function of complex tissues. Susan Herring, reviewing osteogenesis and vasculogenesis, explained that the vascular arrangement precedes and dictates the architecture of the new bone, and proposed that engineering of osseous tissues might benefit from preconstruction of an appropriate vasculature. Jennifer Elisseeff explored the formation of complex tissue structures based on the example of stratified cartilage engineered using stem cells and hydrogels. Helen Lu discussed engineering of tissue interfaces, a problem critical for biological fixation of tendons and ligaments, and the development of a new generation of fixation devices. Rita Kandel discussed the challenges related to the re-creation of the cartilage-bone interface, in the context of tissue engineered joint repair. Frederick Schoen emphasized, in the context of heart valve engineering, the need for including the requirements derived from “adult biology” of tissue remodeling and establishing reliable early predictors of success or failure of tissue engineered implants. Mehmet Toner presented a review of biopreservation techniques and stressed that a new breakthrough in this field may be necessary to meet all the needs of tissue engineering. David Mooney described systems providing temporal and spatial regulation of growth factor availability, which may find utility in virtually all tissue engineering and regeneration applications, including directed in vitro and in vivo vascularization of tissues. Anthony Atala offered a clinician’s perspective for functional tissue regeneration, and discussed new biomaterials that can be used to develop new regenerative technologies. PMID:17518671

MIKOS, ANTONIOS G.; HERRING, SUSAN W.; OCHAREON, PANNEE; ELISSEEFF, JENNIFER; LU, HELEN H.; KANDEL, RITA; SCHOEN, FREDERICK J.; TONER, MEHMET; MOONEY, DAVID; ATALA, ANTHONY; VAN DYKE, MARK E.; KAPLAN, DAVID; VUNJAK-NOVAKOVIC, GORDANA

2010-01-01

369

Coloring Large Complex Networks  

E-print Network

Given a large social or information network, how can we partition the vertices into sets (i.e., colors) such that no two vertices linked by an edge are in the same set while minimizing the number of sets used. Despite the obvious practical importance of graph coloring (e.g., network analysis, machine learning, etc), existing work has not systematically investigated or designed methods for large complex networks. In this work, we develop a framework for coloring large complex networks that is (a) accurate with solutions close to optimal, and (b) fast and scalable for large networks with millions of vertices, (c) flexible for use in a variety of applications. Using this framework as a basis, we propose coloring methods designed for the scale and structure of complex networks. In particular, the classes of methods use triangles, triangle-cores, and other egonet properties as a basis. We systematically compare the proposed methods across a wide range of networks and find a significant improvement over traditional...

Rossi, Ryan A

2014-01-01

370

Terminal imido rhodium complexes.  

PubMed

Compounds of the late transition metals with M=X multiple bonds (X=CR2, NR, O) represent a synthetic challenge, partly overcome by preparative chemists, but with noticeable gaps in the second- and third-row elements. For example, there are no isolated examples of terminal imido rhodium complexes known to date. Described herein is the isolation, characterization, and some preliminary reactivity studies of the first rhodium complexes [Rh(PhBP3)(NR)] (PhBP3=PhB{CH2PPh2}3) with a multiple and terminal Rh=N bond. These imido compounds result from reactions of organic azides with the corresponding rhodium(I) complex having a labile ligand, and display a pseudo-tetrahedral core geometry with an almost linear Rh-N-C arrangement [177.5(2)°] and a short Rh-N bond [1.780(2) Å]. We also show that the Rh=N bond undergoes protonation at the nitrogen atom or addition of H2 , and also engages in nitrene-group transfer and cycloaddition reactions. PMID:24729197

Geer, Ana M; Tejel, Cristina; López, José A; Ciriano, Miguel A

2014-05-26

371

Nanostructure of polysaccharide complexes.  

PubMed

The interaction of gum arabic (GA) with chitosan (Ch) of different degree of deacetylation was studied by turbidity measurements, dynamic light scattering and atomic force microscopy. The structure of the complexes was found to be directly related to the charge density of chitosan molecules. Gum arabic and chitosan with a degree of deacetylation of 75% form soluble complexes with a loosely globular structure of about 250 nm, at weight ratios up to 1.2, if the concentrations are kept low (total biopolymer concentration up to 0.06%). If chitosan has a higher charge density (degree of deacetylation of 93%), colloidal particles are formed, independently of the polymer concentration or ratio. At low concentrations and GA/Ch ratios of 1 or 1.2, the particles have diameters of 200-250 nm. The formation of soluble complexes is attributed to a chitosan lower charge density and the presence of non-charged monomers, which prevent the efficient self-assembly of the macromolecules. PMID:21872261

Coelho, Sílvia; Moreno-Flores, Susana; Toca-Herrera, José L; Coelho, Manuel A N; Pereira, M Carmo; Rocha, Sandra

2011-11-15

372

Training in complex systems  

NASA Astrophysics Data System (ADS)

Some people will talk of a new emerging Complexity Science, other ones will only refer to exploratory approaches to investigate complex systems. Beyond the words, we have to acknowledge that a set of new concepts and new tools have been developed by researchers from various disciplines to deal with interactions between multiple entities and processes rather than on isolated phenomena, to carry out integrated studies on physical, biological or social systems handling multiscale information rather than focusing on controlled case studies, to acknowledge for unpredictability even if the simplest non linear models would apply, etc. The field of complex systems is not yet in a state to be taught in the same way as classical science at University , anyway many masters and PhD curriculum are now proposed to students to cross traditional boundaries and we will give in this talk some examples of educational programmes which are in development in France and in Europe in this context. We will discuss here about the possibility to share on-line training resources in this field, which would benefit to a large audience, including engineers in Soil Science.

Perrier, Edith

2010-05-01

373

Complex transient epileptic amnesia  

Microsoft Academic Search

Transient epileptic amnesia is a rare but probably underrecognized form of temporal lobe epilepsy, which typically manifests as episodic isolated memory loss. Consequently, transient epileptic amnesia may be readily misdiagnosed as a nonepileptic memory dysfunction in older individuals. When appropriately recognized, it has been described as a treatment-responsive syndrome amenable to antiepileptic drugs. We describe a patient with drug-resistant transient

Ryan D. Walsh; Robert E. Wharen; William O. Tatum

2011-01-01

374

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy.  

PubMed

Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of metformin use in the clinic, its molecular mechanism of action remains controversial. In a recent issue of Cancer & Metabolism, Andrzejewski et al. present evidence that metformin acts directly on mitochondria to inhibit complex I and limits the ability of cancer cells to cope with energetic stress. Here, we discuss evidence that supports the role of metformin as a cancer therapeutic. PMID:25347702

Luengo, Alba; Sullivan, Lucas B; Heiden, Matthew G Vander

2014-01-01

375

Plasmid-protein relaxation complexes in Staphylococcus aureus.  

PubMed

Protein-deoxyribonucleic acid relaxation complexes have been demonstrated for six Staphylococcus aureus plasmids out of sixteen examined. Four of these encode stretomycin resistence, have molecular weights of about 2.7 x 10(6), and are isolated as supercoiled molecules that are virtally 100% relaxable by treatment with sodium dodecyl sulfate. It is probable that these four isolates represent a single widely disseminated plasmid species. The other two plasmids showing relaxation complexes have molecular weights of about 3 x 10(6) and encode chloramphenicol resistance. The complexes in these cases are unstable, and it has not been possible to induce more than 50% relaxation by any of the standard treatments. Ten other plasmids do not show detectable complexes. These include three penicillinase plasmids, four tetracycline-resistance plasmids, one plasmid carrying kanamycin-neomycin resistance, and finally, two chloramphenicol-resistance plasmids. PMID:956124

Novick, R

1976-09-01

376

Computational complexity of the quantum separability problem  

E-print Network

Ever since entanglement was identified as a computational and cryptographic resource, researchers have sought efficient ways to tell whether a given density matrix represents an unentangled, or separable, state. This paper gives the first systematic and comprehensive treatment of this (bipartite) quantum separability problem, focusing on its deterministic (as opposed to randomized) computational complexity. First, I review the one-sided tests for separability, paying particular attention to the semidefinite programming methods. Then, I discuss various ways of formulating the quantum separability problem, from exact to approximate formulations, the latter of which are the paper's main focus. I then give a thorough treatment of the problem's relationship with the complexity classes NP, NP-complete, and co-NP. I also discuss extensions of Gurvits' NP-hardness result to strong NP-hardness of certain related problems. A major open question is whether the NP-contained formulation (QSEP) of the quantum separability problem is Karp-NP-complete; QSEP may be the first natural example of a problem that is Turing-NP-complete but not Karp-NP-complete. Finally, I survey all the proposed (deterministic) algorithms for the quantum separability problem, including the bounded search for symmetric extensions (via semidefinite programming), based on the recent quantum de Finetti theorem; and the entanglement-witness search (via interior-point algorithms and global optimization). These two algorithms have the lowest complexity, with the latter being the best under advice of asymptotically optimal point-coverings of the sphere.

Lawrence M. Ioannou

2006-03-22

377

Mixed waste treatment model: Basis and analysis  

SciTech Connect

The Department of Energy`s Programmatic Environmental Impact Statement (PEIS) required treatment system capacities for risk and cost calculation. Los Alamos was tasked with providing these capacities to the PEIS team. This involved understanding the Department of Energy (DOE) Complex waste, making the necessary changes to correct for problems, categorizing the waste for treatment, and determining the treatment system requirements. The treatment system requirements depended on the incoming waste, which varied for each PEIS case. The treatment system requirements also depended on the type of treatment that was desired. Because different groups contributing to the PEIS needed specific types of results, we provided the treatment system requirements in a variety of forms. In total, some 40 data files were created for the TRU cases, and for the MLLW case, there were 105 separate data files. Each data file represents one treatment case consisting of the selected waste from various sites, a selected treatment system, and the reporting requirements for such a case. The treatment system requirements in their most basic form are the treatment process rates for unit operations in the desired treatment system, based on a 10-year working life and 20-year accumulation of the waste. These results were reported in cubic meters and for the MLLW case, in kilograms as well. The treatment system model consisted of unit operations that are linked together. Each unit operation`s function depended on the input waste streams, waste matrix, and contaminants. Each unit operation outputs one or more waste streams whose matrix, contaminants, and volume/mass may have changed as a result of the treatment. These output streams are then routed to the appropriate unit operation for additional treatment until the output waste stream meets the treatment requirements for disposal. The total waste for each unit operation was calculated as well as the waste for each matrix treated by the unit.

Palmer, B.A.

1995-09-01

378

Simple theories of complex lattices  

NASA Astrophysics Data System (ADS)

While the theory of solitons has been very successful for continuous systems, very few nonlinear discrete lattices are amenable to an exact analytical treatment. In these “complex lattices” discreteness can be hostile to the solitons, preventing them to move due to the lack of translational invariance or even to exist as localized excitations. On the other hand, lattice discreteness can sometimes be very helpful. It can stabilize solutions that otherwise would split apart as in the discrete sine-Gordon lattice, or even allow the existence of localized oscillatory modes as exact solutions in systems where they would decay in the continuum limit. It is interesting that many of these phenomena can be understood qualitatively, and sometimes quantitatively, with very simple theories that rely on the usual concepts of linear wave propagation, resonances, linear stability of waves, for instance. There are, however, phenomena specific to discrete nonlinear lattices which allow the build up of large amplitude localized excitations, sometimes out of thermal fluctuations, which are more resistant to simple approaches and could deserve further interest because they may be relevant for various physical systems.

Peyrard, Michel

1998-11-01

379

Medical Treatments for Sexual Problems in Women  

Microsoft Academic Search

\\u000a Cancer today is more of a chronic than a fatal disease: the improving survival rates increase the likelihood of long survival\\u000a after the diagnosis. Unfortunately, cancer treatment is the most frequent cause of premature iatrogenic menopause and psychosexual\\u000a dysfunction. Therefore, an increasing number of cancer survivors have to cope with both the consequences of cancer treatment\\u000a per se, the complex

Alessandra Graziottin; Audrey Serafini

380

Leverage, the treatment relationship, and treatment participation.  

PubMed

OBJECTIVE Although many psychiatric patients experience various forms of pressure or leverage to participate in community treatment, the association between such experiences and treatment participation is controversial. This study evaluated the hypothesis that aspects of the treatment relationship, such as the working alliance, psychological reactance, and perceived coercion, could be important in understanding treatment adherence and satisfaction in a group of patients at risk of experiencing leverage. METHODS A total of 198 outpatients at two community mental health centers completed structured interviews including measures of the treatment relationship, treatment participation, experience of leverage, and clinical functioning. Regression analyses were used to assess associations between the treatment relationship and treatment adherence and satisfaction while concomitantly considering experiences of leverage, demographic characteristics, and clinical functioning. RESULTS Approximately four in ten participants reported experiencing some form of leverage to adhere to treatment during the previous six months, such as pressures related to the criminal justice system, money, housing, and outpatient commitment. Patients who perceived greater coercion to participate in treatment were more likely to report taking their medications as prescribed. Higher satisfaction with treatment was associated with lower perceived coercion, a better working alliance, and lower levels of psychological reactance. CONCLUSIONS Benefits in medication adherence associated with interventions that patients perceive as coercive may come at a cost of decreased satisfaction with treatment. Aspects of the treatment relationship hold promise for individualizing treatment planning in a way that addresses satisfaction as well as adherence. PMID:23412399

McNiel, Dale E; Gormley, Barbara; Binder, Renée L

2013-05-01

381

Linking social complexity and vocal complexity: a parid perspective  

PubMed Central

The Paridae family (chickadees, tits and titmice) is an interesting avian group in that species vary in important aspects of their social structure and many species have large and complex vocal repertoires. For this reason, parids represent an important set of species for testing the social complexity hypothesis for vocal communication—the notion that as groups increase in social complexity, there is a need for increased vocal complexity. Here, we describe the hypothesis and some of the early evidence that supported the hypothesis. Next, we review literature on social complexity and on vocal complexity in parids, and describe some of the studies that have made explicit tests of the social complexity hypothesis in one parid—Carolina chickadees, Poecile carolinensis. We conclude with a discussion, primarily from a parid perspective, of the benefits and costs of grouping and of physiological factors that might mediate the relationship between social complexity and changes in signalling behaviour. PMID:22641826

Krams, Indrikis; Krama, Tatjana; Freeberg, Todd M.; Kullberg, Cecilia; Lucas, Jeffrey R.

2012-01-01

382

Linking social complexity and vocal complexity: a parid perspective.  

PubMed

The Paridae family (chickadees, tits and titmice) is an interesting avian group in that species vary in important aspects of their social structure and many species have large and complex vocal repertoires. For this reason, parids represent an important set of species for testing the social complexity hypothesis for vocal communication--the notion that as groups increase in social complexity, there is a need for increased vocal complexity. Here, we describe the hypothesis and some of the early evidence that supported the hypothesis. Next, we review literature on social complexity and on vocal complexity in parids, and describe some of the studies that have made explicit tests of the social complexity hypothesis in one parid--Carolina chickadees, Poecile carolinensis. We conclude with a discussion, primarily from a parid perspective, of the benefits and costs of grouping and of physiological factors that might mediate the relationship between social complexity and changes in signalling behaviour. PMID:22641826

Krams, Indrikis; Krama, Tatjana; Freeberg, Todd M; Kullberg, Cecilia; Lucas, Jeffrey R

2012-07-01

383

Method for preparing radiopharmaceutical complexes  

DOEpatents

A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.

Jones, Alun G. (Newton Centre, MA); Davison, Alan (Needham, MA); Abrams, Michael J. (Westchester, PA)

1989-05-02

384

Complexing properties of some pyrimidines.  

PubMed

The synthesis of transition metal barbiturate, and thiobarbiturate complexes containing different functional groups of variable electronic character with CoII, NiII, CuII, PdII, and PtII have been prepared. The stereochemistry and the mode of bonding of the complexes were determined by elemental analysis and electronic and vibrational spectra together with their magnetic moment values. Electronic spin resonance of copper complexes were recorded. The Racah parameter of some cobalt and nickel complexes were calculated. Some of the complexes are of mixed stereochemistry. All the PdII or PtII complexes are of square planar geometries. PMID:16440987

Masoud, Mamdouh S; Haggag, Sawsan S; Khalil, Ekram A

2006-01-01

385

Electrocatalytic CO2 Conversion to Oxalate by a Copper Complex  

Microsoft Academic Search

Global warming concern has dramatically increased interest in using CO2 as a feedstock for preparation of value-added compounds, thereby helping to reduce its atmospheric concentration. Here, we describe a dinuclear copper(I) complex that is oxidized in air by CO2 rather than O2; the product is a tetranuclear copper(II) complex containing two bridging CO2-derived oxalate groups. Treatment of the copper(II) oxalate

Raja Angamuthu; Philip Byers; Martin Lutz; Anthony L. Spek; Elisabeth Bouwman

2010-01-01

386

Complex-valued autoencoders.  

PubMed

Autoencoders are unsupervised machine learning circuits, with typically one hidden layer, whose learning goal is to minimize an average distortion measure between inputs and outputs. Linear autoencoders correspond to the special case where only linear transformations between visible and hidden variables are used. While linear autoencoders can be defined over any field, only real-valued linear autoencoders have been studied so far. Here we study complex-valued linear autoencoders where the components of the training vectors and adjustable matrices are defined over the complex field with the L(2) norm. We provide simpler and more general proofs that unify the real-valued and complex-valued cases, showing that in both cases the landscape of the error function is invariant under certain groups of transformations. The landscape has no local minima, a family of global minima associated with Principal Component Analysis, and many families of saddle points associated with orthogonal projections onto sub-space spanned by sub-optimal subsets of eigenvectors of the covariance matrix. The theory yields several iterative, convergent, learning algorithms, a clear understanding of the generalization properties of the trained autoencoders, and can equally be applied to the hetero-associative case when external targets are provided. Partial results on deep architecture as well as the differential geometry of autoencoders are also presented. The general framework described here is useful to classify autoencoders and identify general properties that ought to be investigated for each class, illuminating some of the connections between autoencoders, unsupervised learning, clustering, Hebbian learning, and information theory. PMID:22622264

Baldi, Pierre; Lu, Zhiqin

2012-09-01

387

Complex-Valued Autoencoders  

PubMed Central

Autoencoders are unsupervised machine learning circuits, with typically one hidden layer, whose learning goal is to minimize an average distortion measure between inputs and outputs. Linear autoencoders correspond to the special case where only linear transformations between visible and hidden variables are used. While linear autoencoders can be defined over any field, only real-valued linear autoencoders have been studied so far. Here we study complex-valued linear autoencoders where the components of the training vectors and adjustable matrices are defined over the complex field with the L2 norm. We provide simpler and more general proofs that unify the real-valued and complex-valued cases, showing that in both cases the landscape of the error function is invariant under certain groups of transformations. The landscape has no local minima, a family of global minima associated with Principal Component Analysis, and many families of saddle points associated with orthogonal projections onto sub-space spanned by sub-optimal subsets of eigenvectors of the covariance matrix. The theory yields several iterative, convergent, learning algorithms, a clear understanding of the generalization properties of the trained autoencoders, and can equally be applied to the hetero-associative case when external targets are provided. Partial results on deep architecture as well as the differential geometry of autoencoders are also presented. The general framework described here is useful to classify autoencoders and identify general properties that ought to be investigated for each class, illuminating some of the connections between autoencoders, unsupervised learning, clustering, Hebbian learning, and information theory. PMID:22622264

Baldi, Pierre; Lu, Zhiqin

2012-01-01

388

The Partition Bound for Classical Communication Complexity and Query Complexity  

Microsoft Academic Search

We describe new lower bounds for randomized communication complexity and\\u000aquery complexity which we call the partition bounds. They are expressed as the\\u000aoptimum value of linear programs. For communication complexity we show that the\\u000apartition bound is stronger than both the rectangle\\/corruption bound and the\\u000a\\\\gamma_2\\/generalized discrepancy bounds. In the model of query complexity we\\u000ashow that the partition

Rahul Jain; Hartmut Klauck

2009-01-01

389

Complexity, contingency, and criticality.  

PubMed Central

Complexity originates from the tendency of large dynamical systems to organize themselves into a critical state, with avalanches or "punctuations" of all sizes. In the critical state, events which would otherwise be uncoupled become correlated. The apparent, historical contingency in many sciences, including geology, biology, and economics, finds a natural interpretation as a self-organized critical phenomenon. These ideas are discussed in the context of simple mathematical models of sandpiles and biological evolution. Insights are gained not only from numerical simulations but also from rigorous mathematical analysis. Images Fig. 3 Fig. 4 PMID:11607561

Bak, P; Paczuski, M

1995-01-01

390

Organization of complex networks  

NASA Astrophysics Data System (ADS)

Many large complex systems can be successfully analyzed using the language of graphs and networks. Interactions between the objects in a network are treated as links connecting nodes. This approach to understanding the structure of networks is an important step toward understanding the way corresponding complex systems function. Using the tools of statistical physics, we analyze the structure of networks as they are found in complex systems such as the Internet, the World Wide Web, and numerous industrial and social networks. In the first chapter we apply the concept of self-similarity to the study of transport properties in complex networks. Self-similar or fractal networks, unlike non-fractal networks, exhibit similarity on a range of scales. We find that these fractal networks have transport properties that differ from those of non-fractal networks. In non-fractal networks, transport flows primarily through the hubs. In fractal networks, the self-similar structure requires any transport to also flow through nodes that have only a few connections. We also study, in models and in real networks, the crossover from fractal to non-fractal networks that occurs when a small number of random interactions are added by means of scaling techniques. In the second chapter we use k-core techniques to study dynamic processes in networks. The k-core of a network is the network's largest component that, within itself, exhibits all nodes with at least k connections. We use this k-core analysis to estimate the relative leadership positions of firms in the Life Science (LS) and Information and Communication Technology (ICT) sectors of industry. We study the differences in the k-core structure between the LS and the ICT sectors. We find that the lead segment (highest k-core) of the LS sector, unlike that of the ICT sector, is remarkably stable over time: once a particular firm enters the lead segment, it is likely to remain there for many years. In the third chapter we study how epidemics spread though networks. Our results indicate that a virus is more likely to infect a large area of a network if it originates at a node contained within k-core of high index k.

Kitsak, Maksim

391

Complexity Science for Simpletons  

E-print Network

In this article, we shall describe some of the most interesting topics in the subject of Complexity Science for a general audience. Anyone with a solid foundation in high school mathematics (with some calculus) and an elementary understanding of computer programming will be able to follow this article. First, we shall explain the significance of the P versus NP problem and solve it. Next, we shall describe two other famous mathematics problems, the Collatz 3n+1 Conjecture and the Riemann Hypothesis, and show how both Chaitin's incompleteness theorem and Wolfram's notion of "computational irreducibility" are important for understanding why no one has, as of yet, solved these two problems.

Craig Alan Feinstein

2005-07-05

392

Physics and complexity  

PubMed Central

This paper is concerned with complex macroscopic behaviour arising in many-body systems through the combinations of competitive interactions and disorder, even with simple ingredients at the microscopic level. It attempts to indicate and illustrate the richness that has arisen, in conceptual understanding, in methodology and in application, across a large range of scientific disciplines, together with a hint of some of the further opportunities that remain to be tapped. In doing so, it takes the perspective of physics and tries to show, albeit rather briefly, how physics has contributed and been stimulated. PMID:20123753

Sherrington, David

2010-01-01

393

Quantum complex networks  

E-print Network

In recent years, new algorithms and cryptographic protocols based on the laws of quantum physics have been designed to outperform classical communication and computation. We show that the quantum world also opens up new perspectives in the field of complex networks. Already the simplest model of a classical random network changes dramatically when extended to the quantum case, as we obtain a completely distinct behavior of the critical probabilities at which different subgraphs appear. In particular, in a network of N nodes, any quantum subgraph can be generated by local operations and classical communication if the entanglement between pairs of nodes scales as 1/N^2.

S. Perseguers; M. Lewenstein; A. Acín; J. I. Cirac

2009-07-19

394

Underground Coal Thermal Treatment  

SciTech Connect

The long-term objective of this work is to develop a transformational energy production technology by insitu thermal treatment of a coal seam for the production of substitute natural gas (SNG) while leaving much of the coalâ??s carbon in the ground. This process converts coal to a high-efficiency, low-GHG emitting gas fuel. It holds the potential of providing environmentally acceptable access to previously unusable coal resources. This topical report discusses the development of experimental capabilities, the collection of available data, and the development of simulation tools to obtain process thermo-chemical and geo-thermal parameters in preparation for the eventual demonstration in a coal seam. It also includes experimental and modeling studies of CO{sub 2} sequestration. Efforts focused on: â?¢ Constructing a suite of three different coal pyrolysis reactors. These reactors offer the ability to gather heat transfer, mass transfer and kinetic data during coal pyrolysis under conditions that mimic in situ conditions (Subtask 6.1). â?¢ Studying the operational parameters for various underground thermal treatment processes for oil shale and coal and completing a design matrix analysis for the underground coal thermal treatment (UCTT). This analysis yielded recommendations for terms of targeted coal rank, well orientation, rubblization, presence of oxygen, temperature, pressure, and heating sources (Subtask 6.2). â?¢ Developing capabilities for simulating UCTT, including modifying the geometry as well as the solution algorithm to achieve long simulation times in a rubblized coal bed by resolving the convective channels occurring in the representative domain (Subtask 6.3). â?¢ Studying the reactive behavior of carbon dioxide (CO{sub 2}) with limestone, sandstone, arkose (a more complex sandstone) and peridotite, including mineralogical changes and brine chemistry for the different initial rock compositions (Subtask 6.4). Arkose exhibited the highest tendency of participating in mineral reactions, which can be attributed to the geochemical complexity of its initial mineral assemblage. In experiments with limestone, continuous dissolution was observed with the release of CO{sub 2} gas, indicated by the increasing pressure in the reactor (formation of a gas chamber). This occurred due to the lack of any source of alkali to buffer the solution. Arkose has the geochemical complexity for permanent sequestration of CO{sub 2} as carbonates and is also relatively abundant. The effect of including NH{sub 3} in the injected gas stream was also investigated in this study. Precipitation of calcite and trace amounts of ammonium zeolites was observed. A batch geochemical model was developed using Geochemists Workbench (GWB). Degassing effect in the experiments was corrected using the sliding fugacity model in GWB. Experimental and simulation results were compared and a reasonable agreement between the two was observed.

P. Smith; M. Deo; E. Eddings; A. Sarofim; K. Gueishen; M. Hradisky; K. Kelly; P. Mandalaparty; H. Zhang

2011-10-30

395

Nuclear Weapons Complex reconfiguration study  

SciTech Connect

Shortly after assuming duties as Secretary of Energy, I reviewed the Nuclear Weapons Complex Modernization Report'' submitted to the Congress in January 1989 as required by the National Defense Authorization Act of 1988 and 1989. My review showed that several of the report's assumptions needed to be re-evaluated. During this eighteen-month review, dramatic world changes forced further reassessments of the future Nuclear Weapons Complex. These changes are reflected in the new report. The new report presents a plan to achieve a reconfigured complex, called Complex-21. Complex-21 would be smaller, less diverse, and less expensive to operated than the Complex of today. Complex-21 would be able to safely and reliability support nuclear deterrent stockpile objectives set forth by the President and funded by the Congress. It would be consistent with realities of the emerging international security environment and flexible enough to accommodate the likely range of deterrent contingencies. In addition, Complex-21 would be constructed and operated to comply with all applicable federal, state, and local laws, regulations, and orders. Achieving Complex-21 will require significant resources. This report provides and organized approach toward selecting the most appropriate configuration for Complex-21, satisfying environmental requirements, and minimizing costs. The alternative -- to continue to use piecemeal fixes to run an antiquated complex -- will be more expensive and provide a less reliable Nuclear Weapons Complex. As a consequence, implementation of the Complex-21 plan is considered necessary to ensure continued viability of our nuclear deterrent.

Not Available

1991-01-01

396

Community Detection in Quantum Complex Networks  

NASA Astrophysics Data System (ADS)

Determining community structure is a central topic in the study of complex networks, be it technological, social, biological or chemical, static or in interacting systems. In this paper, we extend the concept of community detection from classical to quantum systems—a crucial missing component of a theory of complex networks based on quantum mechanics. We demonstrate that certain quantum mechanical effects cannot be captured using current classical complex network tools and provide new methods that overcome these problems. Our approaches are based on defining closeness measures between nodes, and then maximizing modularity with hierarchical clustering. Our closeness functions are based on quantum transport probability and state fidelity, two important quantities in quantum information theory. To illustrate the effectiveness of our approach in detecting community structure in quantum systems, we provide several examples, including a naturally occurring light-harvesting complex, LHCII. The prediction of our simplest algorithm, semiclassical in nature, mostly agrees with a proposed partitioning for the LHCII found in quantum chemistry literature, whereas our fully quantum treatment of the problem uncovers a new, consistent, and appropriately quantum community structure.

Faccin, Mauro; Migda?, Piotr; Johnson, Tomi H.; Bergholm, Ville; Biamonte, Jacob D.

2014-10-01

397

Treatment of binge eating disorder.  

PubMed

The two specialty psychological therapies of CBT and IPT remain the treatments of choice for the full range of BED patients, particularly those with high levels of specific eating disorder psychopathology such as overvaluation of body shape and weight. They produce the greatest degree of remission from binge eating as well as improvement in specific eating disorder psychopathology and associated general psychopathology such as depression. The CBT protocol evaluated in the research summarized above was the original manual from Fairburn and colleagues. Fairburn has subsequently developed a more elaborate and sophisticated form of treatment, namely, enhanced CBT (CBT-E) for eating disorders. Initial research suggests that CBT-E may be more effective than the earlier version with bulimia nervosa and Eating Disorder Not Otherwise Specified patients. CBT-E has yet to be evaluated for the treatment of BED, although it would currently be the recommended form of CBT. Of relevance in this regard is that the so-called broad form of the new protocol includes 3 optional treatment modules that could be used to address more complex psychopathology in BED patients. One of the modules targeted at interpersonal difficulties is IPT, as described earlier in this chapter. Thus, the broader protocol could represent a combination of the two currently most effective therapies for BED. Whether this combined treatment proves more effective than either of the components alone, particularly for a subset of BED patients with more complex psychopathology, remains to be tested. CBT-E also includes a module designed to address what Fairburn terms “mood intolerance” (problems in coping with negative affect) that can trigger binge eating and purging. The content and strategies of this mood intolerance module overlap with the emotional regulation and distress tolerance skills training of Linehan's dialectical behavior therapy (DBT). Two randomized controlled trials have tested the efficacy of an adaptation of DBT for the treatment of BED (DBT-BED) featuring mindfulness, emotion regulation, and distress tolerance training. A small study by Telch and colleagues found that modified DBT-BED was more effective than a wait list control in eliminating binge eating. A second study showed that DBT-BED resulted in a significantly greater remission rate from binge eating at posttreatment than a group comparison treatment designed to control for nonspecific therapeutic factors such as treatment alliance and expectations.50 This difference between the two treatments disappeared over a 12-month follow-up, indicating the absence of DBT-BED-specific influences on long-term outcomes. Both CBT and IPT have been shown to be more effective in eliminating binge eating than BWL in controlled, comparative clinical trials. Nonetheless, BWL has been effective in reducing binge eating and associated eating problems in BED patients in some studies and might be suitable for treatment of BED patients without high levels of specific eating disorder psychopathology. A finding worthy of future research is the apparent predictive value of early treatment response to BWL, indicating when BWL is likely to prove effective or not. No evidence supports the concern that BWL's emphasis on moderate caloric restriction either triggers or exacerbates binge eating in individuals with BED. Initially, CBTgsh was recommended as a feasible first-line treatment that might be sufficient treatment for a limited subset of patients in a stepped care approach. More recent research, however, has shown that CBTgsh seems to be as effective as a specialty therapy, such as IPT, with a majority of BED patients. The subset of patients that did not respond well to CBTgsh in this research were those with a high level of specific eating disorder psychopathology, as noted. A plausible explanation for this moderator effect is that the original Fairburn CBTgsh manual does not include an explicit emphasis on body shape and weight concerns. Subsequent implementation of this treatment has incorporated a module that dire

Wilson, G Terence

2011-12-01

398

What do clinicians need from a rehabilitation treatment taxonomy? An alternate approach for describing treatment content versus process.  

PubMed

Clinician feedback and thought processes about treatment classification and description will aid development of the rehabilitation treatment taxonomy (RTT) presented in this supplement. Here, we discuss comparisons between the proposed RTT and an inductive practice-based evidence (PBE) model used to describe rehabilitation treatments. Interviews with clinicians well versed with PBE highlight the complexity of rehabilitation treatments, and bring to light potential advantages and challenges of a deductive, theory-driven classification to uncover the black box of rehabilitation. PMID:24370328

Fasoli, Susan E; Chen, Christine C

2014-01-01

399

Complex aperture networks  

NASA Astrophysics Data System (ADS)

A complex network approach is proposed for studying the shear behavior of a rough rock joint. Similarities between aperture profiles are established, and a functional complex network-in each shear displacement-is constructed in two directions: parallel and perpendicular to the shear direction. We find that the growth of the clustering coefficient and that of the number of edges are approximately scaled with the development of shear strength and hydraulic conductivity, which could possibly be utilized to estimate and formulate a friction law and the evolution of shear distribution over asperities. Moreover, the frictional interface is mapped in the global-local parameter space of the corresponding functional friction network, showing the evolution path and, eventually, the residual stage. Furthermore, we show that with respect to shear direction, parallel aperture patches are more adaptable to environmental stimuli than perpendicular profiles. We characterize the pure-contact profiles using the same approach. Unlike the first case, the later networks show a growing trend while in the residual stage; a saturation of links is encoded in contact networks.

Ghaffari, H. O.; Sharifzadeh, M.; Young, R. Paul

2013-02-01

400

Complex Compound Chemical Heat Pumps  

E-print Network

Complex-compound solid-vapor fluid pairs can be used in heat of reaction heat pumps for temperature amplifier (TA) as well as heat amplifier (HA) cycle configurations. This report describes the conceptual hardware design for complex compound...

Rockenfeller, U.; Langeliers, J.; Horn, G.

401

MA 530 Complex Analysis: Review  

E-print Network

... Lafayette, IN, USA. Contents. 1 How to prove analytic (holomorphic, complex differentiable)? 3. 1.1 Definition (Difference Quotient) . .... It should be emphasized that in the above limit, h is a complex number that may approach 0 from any ...

2013-01-10

402

Ectopic pregnancy after infertility treatment  

PubMed Central

Early pregnancy complications are more common in women who conceive after infertility treatment. Most of these occur before 12 weeks of gestation and include miscarriage, vaginal bleeding, intrauterine hematoma, vanishing twin, and ectopic pregnancy (EP). The incidence of EPs following infertility treatment is much higher compared with that in spontaneous pregnancies. The occurrence of an EP is very distressing to an infertile couple, who has lots of hopes pinned on the treatment outcome, especially because of the cost incurred and the physical and mental trauma both have gone through during the treatment process. The association between infertility and EP is complex, as it can be a consequence of infertility as well as a cause. The two principal risk factors for an EP are genital tract infections and tubal surgeries. Though several etiologies are proposed, but patients with tubal factor infertility are at an increased risk of an EP. Earlier diagnosis of EP helps to improve prognosis and optimize subsequent fertility. It is pivotal to evaluate the likelihood of subsequent occurrence of an EP and be too vigilant when treating. The correct choice of the treatment modality should be made to prevent the recurrence. The early prediction of the pregnancy outcome therefore has great importance for both the couple and clinician. Today with the help of sensitive beta human chorionic gonadotropin (?-hCG) assays and transvaginal sonography, one can diagnose an EP prior to symptoms, and conservative treatment for the preservation of the fallopian tube is possible. Conservative management in the form of expectant and medical management should be considered as a first-line treatment modality, provided that the overall clinical picture suggests that it is safe to do so. If not, laparoscopic management of EPs appears to be the favored approach of management as compared to laparotomy. PMID:23162353

Patil, Madhuri

2012-01-01

403

Long-Wavelength Elastic Interactions in Complex Crystals  

NASA Astrophysics Data System (ADS)

The long-wavelength (LWL) limit of the elastic interactions in complex non-Bravais lattices is investigated on the basis of microscopic elasticity theory. The conceptual simplicity of our approach enables large-scale simulations in materials with complex crystalline structures. We demonstrate the method by calculating the LWL elastic energy of hcp-based dilute Mg alloys for a variety of impurities. Our results show that for large coherent precipitates, the strain-induced interactions control the shape along the hexagonal axis whereas the surface energy dictates the basal growth. Our method allows a straightforward treatment of the long-range elastic interactions in the cluster expansion method for complex crystals.

Diaz Ortiz, Alejandro; Kurta, Ruslan; Bugaev, Volodymyr

2010-03-01

404

STUDIES ON CIRCULATING IMMUNE COMPLEXES  

PubMed Central

The relationship between certain physicochemical properties of circulating immune complexes and their ability to localize in vessel walls during a state of increased permeability was studied. The ability to become deposited was related to the large size of complexes, rather than to their net charge or to a specific affinity between complexes and structures of vessel walls. Soluble complexes with sedimentation rates greater than 19S were capable of being entrapped along the vessel wall membranes, while complexes smaller than this were not. These large complexes were removed rapidly from the circulation, while smaller complexes persisted. Minimal levels of total complexes in the circulation necessary for detectable vascular localization were found to be as low as 15 µg antibody N/ml plasma. In experimental serum sickness, a disease known to be induced by circulating immune complexes, the development of vascular and glomerular lesions occurred almost exclusively in rabbits having large (greater than 19S) circulating immune complexes. Animals with smaller complexes did not show deposition of complexes in glomeruli or development of glomerulonephritis. Their incidence of vasculitis was markedly reduced. PMID:4169437

Cochrane, Charles G.; Hawkins, David

1968-01-01

405

Institutional Complexity and Organizational Responses  

Microsoft Academic Search

Organizations face institutional complexity whenever they confront incompatible prescriptions from multiple institutional logics. Our interest is in how plural institutional logics, refracted through field-level structures and processes, are experienced within organizations and how organizations respond to such complexity. We draw on a variety of cognate literatures to discuss the field-level structural characteristics and organizational attributes that shape institutional complexity. We

Royston Greenwood; Mia Raynard; Farah Kodeih; Evelyn R. Micelotta; Michael Lounsbury

2011-01-01

406

OXO INCORPORATED METAL ACETYLIDE COMPLEXES  

Microsoft Academic Search

Studies on organometallic oxo complexes have intensified in recent years due to their implications in catalytic oxidations or as reagents in the oxidation of organic molecules. Synthesis of such complexes containing a hydrocarbon ligand besides the carbonyl and oxo provides an opportunity to obtain complexes with both low oxidation state metal carbonyl fragment and high oxidation state metal oxide fragment

Pradeep Mathur; Saurav Chatterjee

2005-01-01

407

Researching Classrooms: Complexity and Chaos  

ERIC Educational Resources Information Center

This article presents a critical review of complexity theory in relation to educational research. The "analytical reductionist" approach is one in which the educational researcher seeks to reduce complex wholes to particular factors and to identify correlations between them and desirable outcomes. Complexity theory shows how this approach in…

Radford, Mike

2006-01-01

408

Quantum Computational Complexity John Watrous  

E-print Network

Quantum Computational Complexity John Watrous Institute for Quantum Computing and School computations V. Quantum proofs VI. Quantum interactive proof systems VII. Other selected notions in quantum studied model of quantum computation. Quantum complexity class. A quantum complexity class is a collection

Watrous, John

409

Complexity Measures from Interaction Structures  

E-print Network

We evaluate new complexity measures on the symbolic dynamics of coupled tent maps and cellular automata. These measures quantify complexity in terms of $k$-th order statistical dependencies that cannot be reduced to interactions between $k-1$ units. We demonstrate that these measures are able to identify complex dynamical regimes.

Thomas Kahle; Eckehard Olbrich; Juergen Jost; Nihat Ay

2008-06-16

410

Deadlines and the purgatorial complex  

Microsoft Academic Search

This paper draws on Le Goff's social history of purgatory and Richard Fenn's concept of the purgatorial complex to outline a social history of deadlines. The purgatory complex is a form of sadomasochism where time is the disciplining tool. According to Fenn the purgatorial complex has its origins in the medieval invention of purgatory, the Protestantism of Richard Baxter, North

Eileen Willis

2000-01-01

411

Complexity in scalable computing.  

SciTech Connect

The rich history of scalable computing research owes much to a rapid rise in computing platform scale in terms of size and speed. As platforms evolve, so must algorithms and the software expressions of those algorithms. Unbridled growth in scale inevitably leads to complexity. This special issue grapples with two facets of this complexity: scalable execution and scalable development. The former results from efficient programming of novel hardware with increasing numbers of processing units (e.g., cores, processors, threads or processes). The latter results from efficient development of robust, flexible software with increasing numbers of programming units (e.g., procedures, classes, components or developers). The progression in the above two parenthetical lists goes from the lowest levels of abstraction (hardware) to the highest (people). This issue's theme encompasses this entire spectrum. The lead author of each article resides in the Scalable Computing Research and Development Department at Sandia National Laboratories in Livermore, CA. Their co-authors hail from other parts of Sandia, other national laboratories and academia. Their research sponsors include several programs within the Department of Energy's Office of Advanced Scientific Computing Research and its National Nuclear Security Administration, along with Sandia's Laboratory Directed Research and Development program and the Office of Naval Research. The breadth of interests of these authors and their customers reflects in the breadth of applications this issue covers. This article demonstrates how to obtain scalable execution on the increasingly dominant high-performance computing platform: a Linux cluster with multicore chips. The authors describe how deep memory hierarchies necessitate reducing communication overhead by using threads to exploit shared register and cache memory. On a matrix-matrix multiplication problem, they achieve up to 96% parallel efficiency with a three-part strategy: intra-node multithreading, non-blocking inter-node message passing, and a dedicated communications thread to facilitate concurrent communications and computations. On a quantum chemistry problem, they spawn multiple computation threads and communication threads on each node and use one-sided communications between nodes to minimize wait times. They reduce software complexity by evolving a multi-threaded factory pattern in C++ from a working, message-passing program in C.

Rouson, Damian W. I.

2008-12-01

412

Complex modes in unstable quadratic bosonic forms  

E-print Network

We discuss the necessity of using non-standard boson operators for diagonalizing quadratic bosonic forms which are not positive definite and its convenience for describing the temporal evolution of the system. Such operators correspond to non-hermitian coordinates and momenta and are associated with complex frequencies. As application, we examine a bosonic version of a BCS-like pairing Hamiltonian, which, in contrast with the fermionic case, is stable just for limited values of the gap parameter and requires the use of the present extended treatment for a general diagonal representation. The dynamical stability of such forms and the occurrence of non-diagonalizable cases are also discussed.

R. Rossignoli; A. M. Kowalski

2014-04-17

413

Complex modes in unstable quadratic bosonic forms  

SciTech Connect

We discuss the necessity of using nonstandard boson operators for diagonalizing quadratic bosonic forms which are not positive definite and its convenience for describing the temporal evolution of the system. Such operators correspond to non-Hermitian coordinates and momenta and are associated with complex frequencies. As application, we examine a bosonic version of a BCS-like pairing Hamiltonian, which, in contrast with the fermionic case, is stable just for limited values of the gap parameter and requires the use of the present extended treatment for a general diagonal representation. The dynamical stability of such forms and the occurrence of nondiagonalizable cases are also discussed.

Rossignoli, R.; Kowalski, A.M. [Departamento de Fisica, Universidad Nacional de La Plata, C.C.67, La Plata (1900) (Argentina)

2005-09-15

414

Evaluation and management of premature ventricular complexes.  

PubMed

Premature ventricular complexes (PVCs) are a common cause of palpitations. Related symptoms include difficulty breathing, chest pain, fatigue, and dizziness. PVCs are also commonly detected incidentally on electrocardiography, outpatient ambulatory monitoring, and inpatient telemetry. Treatment goals include palliating symptoms, restoring cardiac function if affected, and preventing progression to tachycardia-related cardiomyopathy if the PVC burden is high, even in patients without symptoms. Responses to caffeine reduction, cessation of stimulants, and stress reduction are inconsistent. Aerobic exercise is rarely effective and can sometimes exacerbate PVCs. PMID:23733905

Cantillon, Daniel J

2013-06-01

415

Solid waste management complex site development plan  

SciTech Connect

The main purpose of this Solid Waste Management Complex Site Development Plan is to optimize the location of future solid waste treatment and storage facilities and the infrastructure required to support them. An overall site plan is recommended. Further, a series of layouts are included that depict site conditions as facilities are constructed at the SWMC site. In this respect the report serves not only as the siting basis for future projects, but provides siting guidance for Project W-112, as well. The plan is intended to function as a template for expected growth of the site over the next 30 years so that future facilities and infrastructure will be properly integrated.

Greager, T.M.

1994-09-30

416

[Role of enterosorbents in treatment of complicated varicose disease].  

PubMed

Results of treatment of 43 patients, suffering varicose disease, complicated by trophic disorders, were analyzed. To the patients a complex was prescribed, including sorpents, angioprotectors, locally - ointments. There were operated 14 patients. PMID:25252553

Biliaieva, O O; Korzhyk, N P; Myronov, O M; Balins'ka, M I; Iemets', V V

2014-06-01

417

Bipolar Disorder in Adolescence: Diagnosis and Treatment.  

ERIC Educational Resources Information Center

Due to developmental issues and overlapping symptoms with other disorders, diagnosing bipolar disorder in adolescents is often a confusing and complex process. This article highlights diagnostic criteria, symptoms and behaviors, and the differential diagnosis process. Treatment options are also discussed. (Contains 17 references.) (GCP)

Wilkinson, Great Buyck; Taylor, Priscilla; Holt, Jan R.

2002-01-01

418

Toward a Unified Treatment for Emotional Disorders  

ERIC Educational Resources Information Center

Over 40 years of development of cognitive behavioral approaches to treating anxiety and related emotional disorders have left us with highly efficacious treatments that are increasingly widely accepted. Nevertheless, these manualized protocols have become numerous and somewhat complex, restricting effective training and dissemination. Deepening…

Barlow, David H.; Allen, Laura B.; Choate, Molly L.

2004-01-01

419

Quantum Hamiltonian Complexity  

E-print Network

We survey the growing field of Quantum Hamiltonian Complexity, which includes the study of Quantum Constraint Satisfaction. In particular, our aim is to provide a computer science-oriented introduction to the subject in order to help bridge the language barrier between computer scientists and physicists in the field. As such, we include the following in this paper: (1) The motivations and history of the field, (2) a glossary of condensed matter physics terms explained in computer-science friendly language, (3) overviews of central ideas from condensed matter physics, such as indistinguishable particles, mean field theory, tensor networks, and area laws, and (4) brief expositions of selected computer science-based results in the area. For example, as part of the latter, we provide a novel information theoretic presentation of Bravyi's polynomial time algorithm for Quantum 2-SAT.

Sevag Gharibian; Yichen Huang; Zeph Landau; Seung Woo Shin

2014-01-16

420

Complexity, Metastability and Nonextensivity  

NASA Astrophysics Data System (ADS)

Work and heat fluctuations in systems with deterministic and stochastic forces / E. G. D. Cohen and R. Van Zon -- Is the entropy S[symbol] extensive or nonextensive? / C. Tsallis -- Superstatistics: recent developments and applications / C. Beck -- Two stories outside Boltzmann-Gibbs statistics: Mori's Q-phase transitions and glassy dynamics at the onset of chaos / A. Robledo, F. Baldovin and E. Mayoral -- Time-averages and the heat theorem / A. Carati -- Fundamental formulae and numerical evidences for the central limit theorem in Tsallis statistics / H. Suyari -- Generalizing the Planck distribution / A. M. C. Soma and C. Tsallis -- The physical roots of complexity: renewal or modulation? / P. Grigolini -- Nonequivalent ensembles and metastability / H. Touchette and R. S. Ellis -- Statistical physics for cosmic structures / L. Pietronero and F. Sylos Labini -- Metastability and anomalous behavior in the HMF model: connections to nonextensive thermodynamics and glassy dynamics / A. Pluchino, A. Rapisarda and V. Latora -- Vlasov analysis of relaxation and meta-equilibrium / C. Anteneodo and R. O. Vallejos -- Weak chaos in large conservative systems - infinite-range coupled standard maps / L. G. Moyano, A. P. Majtey and C. Tsallis -- Deterministc aging / E. Barkai -- Edge of chaos of the classical kicked top map: sensitivity to initial conditions / S. M. Duarte Queirós and C. Tsallis -- What entropy at the edge of chaos? / M. Lissia, M. Coraddu and R. Tonelli -- Fractal growth of carbon schwarzites / G. Benedek ... [et al.] -- Clustering and interface propagation in interacting particle dynamics / A. Provata and V. K. Noussiou -- Resonant activation and noise enhanced stability in Josephson junctions / A. L. Pankratov and B. Spagnolo -- Symmetry breaking induced directed motions / C.-H. Chang and T. Y. Tsong -- General theory of Galilean-invariant entropic lattic Boltzmann models / B. M. Boghosian -- Unifying approach to the jamming transition in granular media and the glass transition in thermal systems / A. Coniglio ... [et al.] -- Supersymmetry and metastability in disordered systems / I. Giardinu, A. Cavagna and G. Parisi -- The metastable liquid-liquid phase transition: from water to colloids and liquid metals / G. Franzese and H. E. Stanley -- Optimization by thermal cycling / A. Möbius, K. H. Hoffmann and C. Schön -- Ultra-thin magnetic films and the structural glass transition: a modelling analogy / S. A. Cannas ... [et al.] -- Non-extensivity of inhomogeneous magnetic systems / M. S. Reis ... [et al.] -- Multifractal analysis of turbulence and granular flow / T. Arimitsu and N. Arimitsu -- Application of superstatistics to atmospheric turbulence / S. Rizzo and A. Rapisarda -- Complexity of perceptual processes / F. T. Arecchi -- Energetic model of tumor growth / P. Castorina and D. Zappalá -- Active Brownian motion - stochastic dynamics of swarms / W. Ebeling and U. Erdmann -- Complexity in the collective behaviour of humans / T. Vicsek -- Monte Carlo simulations of opinion dynamics / S. Fortunato -- A Merton-like approach to pricing debt based on a non-Gaussian asset model / L. Borland, J. Evnine and B. Pochart -- The subtle nature of market efficiency / J.-P. Bouchaud -- Correlation based hierarchical clustering in financial time series / S. Miccichè, F. Lillo and R. N. Mantegna -- Path integrals and exotic options: methods and numerical results / G. Bormetti ... [et al.] -- Aging of event-event correlation of earthquake aftershocks / S. Abe and N. Suzuki -- Aging in earthquakes model / U. Tirnakli -- The Olami-Feder-Christensen model on a small-world topology / F. Caruso ... [et al.] -- Networks as Renormalized models for emergent behavior in physical systems / M. Paczuski -- Energy landscapes, scale-free networks and Apollonian packings / J. P. K. Doye and C. P. Massen -- Epidemic modeling and complex realities / M. Barthélemy ... [et al.] -- The importance of being central / P. Crucitti and V. Latora.

Beck, C.; Benedek, G.; Rapisarda, A.; Tsallis, C.

421

Complex pendulum biomass sensor  

DOEpatents

A complex pendulum system biomass sensor having a plurality of pendulums. The plurality of pendulums allow the system to detect a biomass height and density. Each pendulum has an angular deflection sensor and a deflector at a unique height. The pendulums are passed through the biomass and readings from the angular deflection sensors are fed into a control system. The control system determines whether adjustment of machine settings is appropriate and either displays an output to the operator, or adjusts automatically adjusts the machine settings, such as the speed, at which the pendulums are passed through the biomass. In an alternate embodiment, an entanglement sensor is also passed through the biomass to determine the amount of biomass entanglement. This measure of entanglement is also fed into the control system.

Hoskinson, Reed L. (Rigby, ID); Kenney, Kevin L. (Idaho Falls, ID); Perrenoud, Ben C. (Rigby, ID)

2007-12-25

422

Micellar interpolyelectrolyte complexes.  

PubMed

Interpolyelectrolyte complexes (IPECs) are typically formed when two polyelectrolytes of opposite charge are mixed together in solution. We present an overview of different strategies for the preparation of micellar IPECs, i.e., structures where such IPEC domains form the core or the shell of micelles. In addition, vesicular architectures are considered, where the IPEC domain forms a membrane layer. One intriguing feature of IPECs is that their formation can be directed, their stability towards changes in pH or ionic strength can (to a certain extent) be predicted, and their size can be controlled. Especially the use of ionic/non-ionic block copolymers offers unique potential for the preparation of well-defined and sophisticated nanostructured materials. We also discuss possible applications, especially in the field of life sciences, including biocompatibility, the controlled uptake/release of guest substances, the immobilization of enzymes, or the controlled formation of inorganic/organic hybrid materials. PMID:22814675

Pergushov, Dmitry V; Müller, Axel H E; Schacher, Felix H

2012-11-01

423

Evolution of Biological Complexity  

NASA Astrophysics Data System (ADS)

It is a general rule of nature that larger organisms are more complex, at least as measured by the number of distinct types of cells present. This reflects the fitness advantage conferred by a division of labor among specialized cells over homogeneous totipotency. Yet, increasing size has both costs and benefits, and the search for understanding the driving forces behind the evolution of multicellularity is becoming a very active area of research. This article presents an overview of recent experimental and theoretical work aimed at understanding this biological problem from the perspective of physics. For a class of model organisms, the Volvocine green algae, an emerging hypothesis connects the transition from organisms with totipotent cells to those with terminal germ-soma differentiation to the competition between diffusion and fluid advection created by beating flagella. A number of challenging problems in fluid dynamics, nonlinear dynamics, and control theory emerge when one probes the workings of the simplest multicellular organisms.

Goldstein, Raymond E.

424

Complex Tectonism on Ganymede  

NASA Technical Reports Server (NTRS)

Complex tectonism is evident in these images of Ganymede's surface. The solid state imaging camera on NASA's Galileo spacecraft imaged this region as it passed Ganymede during its second orbit through the Jovian system. The 80 kilometer (50 mile) wide lens-shaped feature in the center of the image is located at 32 degrees latitude and 188 degrees longitude along the border of a region of ancient dark terrain known as Marius Regio, and is near an area of younger bright terrain named Nippur Sulcus. The tectonism that created the structures in the bright terrain nearby has strongly affected the local dark terrain to form unusual structures such as the one shown here. The lens-like appearance of this feature is probably due to shearing of the surface, where areas have slid past each other and also rotated slightly. Note that in several places in these images, especially around the border of the lens-shaped feature, bright ridges appear to turn into dark grooves. Analysis of the geologic structures in areas like this are helping scientists to understand the complex tectonic history of Ganymede.

North is to the top-left of the image, and the sun illuminates the surface from the southeast. The image covers an area about 63 kilometers (39 miles) by 120 kilometers (75 miles) across at a resolution of 188 meters (627 feet) per picture element. The images were taken on September 6, 1996 at a range of 18,522 kilometers (11,576 miles) by the solid state imaging (CCD) system on NASA's Galileo spacecraft.

The Jet Propulsion Laboratory, Pasadena, CA manages the Galileo mission for NASA's Office of Space Science, Washington, DC. JPL is an operating division of California Institute of Technology (Caltech).

This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://galileo.jpl.nasa.gov.

1997-01-01

425

Childhood Cancers: Treatment  

Cancer.gov

Childhood Cancers: Treatment Childhood Brain Tumors Childhood Brain and Spinal Cord Tumors Treatment Overview (PDQ®) [ patient ] [ health professional ] Expert-reviewed information summary about the treatment of various childhood brain tumors. Childhood

426

Endocrine Treatment of Transsexuals  

MedlinePLUS

... gender When should endocrine treatment of transsexual persons begin? Individuals seeking endocrine treatment must first be diagnosed ... sexual development and maturity. If GnRH-analogue treatment begins very early in puberty, the adolescent’s slightly developed ...

427

Constructing Dynamic Treatment Regimes  

E-print Network

Adaptive Treatments for Children with ADHD Adaptive Pharmacological and Behavioral Treatments for Children, adherence, preferences, response to past treatment, self management skill, side effects, co with ADHD: Sequencing, Combining, and Escalating Doses Nonresponse: Assessed monthly beginning at month 2

Murphy, Susan A.

428

Complex time paths for semiclassical wave packet propagation with complex trajectories.  

PubMed

The use of complex-valued trajectories in semiclassical wave packet methods can lead to problems that prevent calculation of the wave function in certain regions of the configuration space. We investigate this so-called bald spot problem in the context of generalized Gaussian wave packet dynamics. The analysis shows that the bald spot phenomenon is essentially due to the complex nature of the initial conditions for the trajectories. It is, therefore, expected to be a general feature of several semiclassical methods that rely on trajectories with such initial conditions. A bald region is created when a trajectory, needed to calculate the wave function at a given time, reaches a singularity of the potential energy function in the complex plane at an earlier, real time. This corresponds to passage of a branch point singularity across the real axis of the complex time plane. The missing portions of the wave function can be obtained by deforming the time path for the integration of the equations of motion into the complex plane so that the singularity is circumvented. We present examples of bald spots, singularity times, and suitable complex time paths for one-dimensional barrier transmission in the Eckart and Gaussian systems. Although the bald regions for the Eckart system are often localized, they are found to be semi-infinite for the Gaussian system. For the case of deep tunneling, the bald regions for both systems may encompass the entire portion of space occupied by the transmitted wave packet. Thus, the use of complex time paths becomes essential for a treatment of barrier tunneling. PMID:25106577

Petersen, Jakob; Kay, Kenneth G

2014-08-01

429

Treatment planning for the pediatric patient.  

PubMed

Treatment planning for pediatric dental patients is a multifactorial, complex process that requires careful consideration of three distinct areas: the patient's caries risk status, the available treatment options and the child's behavior. Components of a caries risk assessment include: a review of the child's medical and dental history in combination with the findings of the clinical and radiographic examination. All decisions regarding appropriate treatment options for the patient are guided by the outcome of the caries risk assessment. The child's behavior is another overriding consideration as it determines how the treatment can be rendered. Information obtained through careful evaluation of each area results in a treatment plan specifically designed for each child's circumstance. PMID:21355476

McWhorter, Alton G

2010-12-01

430

Operative treatment of nonunions about the elbow.  

PubMed

Nonunions about the elbow present a great challenge to the orthopaedic surgeon. Recent advances have enabled the surgeon to achieve much improved results. The current study outlines the treatment of nonunions of the distal humerus, proximal ulna (including olecranon, Monteggia, and coronoid nonunions), and radial head and neck nonunions. The historic problems of treating these nonunions included the use of inadequate fixation, the poor understanding of the role of soft tissue surgery in the treatment of the stiff elbow, and the failure of previous postoperative rehabilitation protocols. Advances made in the techniques of soft tissue treatment, modern methods of stable internal fixation, and early postoperative rehabilitation all have made an exceptional difference in the surgeon's ability to treat these most complex problems. The current study will provide the reader with a greater understanding of nonunions about the elbow, clinical and technical details for their treatment, and the expected results after treatment. PMID:10660704

Gallay, S H; McKee, M D

2000-01-01

431

Incontinence Treatment: Medication  

MedlinePLUS

... Who We Are Contact Us Donate Incontinence Treatment: Medication Jump to Topic Lifestyle changes Dietary changes Medication Bowel management/retraining program Biofeedback therapy Surgical treatments ...

432

Toward In Vivo Disease Diagnosis and Treatment Using DNA  

Microsoft Academic Search

We propose a technique to diagnose and treat individual cells in the human body. A virus-like system delivers a copy of a diagnosis and treatment DNA complex to each cell. The complex determines whether the cell has a specific disease based on the presence or absence of indicator mRNA molecules and, if the diagnosis is positive, releases a proper drug

Yuriy Brun; Manoj Gopalkrishnan

2006-01-01

433

Synthesis of aluminium complexes bearing a piperazine-based ligand system  

Microsoft Academic Search

Aluminium complexes bearing the N,N-chelating ligand 1,4-bis(2-hydroxy-3,5-di-tert-butyl)piperazine (1) have been synthesised. Both monometallic and bimetallic aluminium methyl complexes (2 and 3, respectively) were prepared by treatment of 1 with the appropriate amount of AlMe3. Complex 2 can be converted to 3 by addition of excess AlMe3. Bimetallic aluminium-ethyl complex 4 was also prepared. Treatment of 1 with AlEt2Cl afforded the

Nick C. Johnstone; Elham S. Aazam; Peter B. Hitchcock; J. Robin Fulton

2010-01-01

434

Complex transient epileptic amnesia.  

PubMed

Transient epileptic amnesia is a rare but probably underrecognized form of temporal lobe epilepsy, which typically manifests as episodic isolated memory loss. Consequently, transient epileptic amnesia may be readily misdiagnosed as a nonepileptic memory dysfunction in older individuals. When appropriately recognized, it has been described as a treatment-responsive syndrome amenable to antiepileptic drugs. We describe a patient with drug-resistant transient epileptic amnesia treated with unilateral temporal lobectomy. Prolonged postictal slowing in the mesial temporal structures was evident on invasive electroencephalography 5 hours after the occurrence of a brief focal seizure. These findings support the theory of a Todd phenomenon as the underlying pathophysiological mechanism in transient epileptic amnesia. PMID:21262589

Walsh, Ryan D; Wharen, Robert E; Tatum, William O

2011-02-01

435

Characterizing the Structural Complexity of Real-World Complex Networks  

Microsoft Academic Search

Although recent research has shown that the complexity of a network depends on its structural organization, which is linked\\u000a to the functional constraints the network must satisfy, there is still no systematic study on how to distinguish topological\\u000a structure and measure the corresponding structural complexity of complex networks. In this paper, we propose the first consistent\\u000a framework for distinguishing and

Jun Wang; Gregory M. Provan

2009-01-01

436

Obesity and Family Systems: A Family FIRO Approach to Assessment and Treatment Planning.  

ERIC Educational Resources Information Center

Presents model for conceptualizing interactional patterns in families presenting for treatment of obesity and method for organizing assessment and for prioritizing treatment strategies. Uses the Family FIRO Model as a framework to organize complex assessment issues, to assign priorities for treatment of issues, and to select appropriate treatment

Doherty, William J.; Harkaway, Jill Elka

1990-01-01

437

Schoolchildren with Dysphagia Associated with Medically Complex Conditions  

ERIC Educational Resources Information Center

Purpose: This article reviews population trends and general characteristics of children with dysphagia in schools, provides an overview of dysphagia teams and the roles of the speech-language pathologist (SLP) in school and hospital settings, and describes assessment and treatment of swallowing and feeding problems in children with complex medical…

Lefton-Greif, Maureen A.; Arvedson, Joan C.

2008-01-01

438

Introduction The management of infectious diseases is complex,  

E-print Network

Review Introduction The management of infectious diseases is complex, especially in an intensive review the development of such models applied to infectious disease management. We use the diagnosis and treatment of infectious diseases Any diagnosis, including that of an infectious disease, is based

Lucas, Peter

439

Removal of cyanides by complexation with ferrous compounds  

SciTech Connect

Alkaline chlorination, an oxidation process with chlorine (Cl{sub 2}) or hypochlorite (ClO{sup {minus}}), is the most widely accepted method of cyanide treatment. However, removal of cyanide from wastewater to the extent required by the effluent limits imposed by Federal and State regulatory authorities is practically impossible, especially when the majority of the cyanide is present as an iron-cyanide complex. One potential treatment method being further investigated uses ferrous (Fe{sup 2+}) compounds to react with free and complex cyanide ions and produce insoluble iron-cyanide complexes. However, sludges generated by this treatment method contain cyanide wastes which may be considered a hazardous waste by the US Environmental Protection Agency (US EPA). The studies reported in this paper demonstrate that ferrous (Fe{sup 2+}) precipitation can remove cyanide ions (both free and complex) to a concentration within the range of 1 to 2 mg/L. The wastewaters utilized in these tests were collected from a coke plant facility. Synthetic cyanide solutions were used in the studied as well. Ferrous compounds used in the studies included commercial-grade ferrous sulfate, commercial-grade ferrous chloride, and spent pickle liquor (containing ferrous ion). The desired effluent quality was successfully attained in the treatment of the above-mentioned wastewaters by using ferrous compounds as well as spent pickle liquor.

Varuntanya, C.P.; Zabban, W. [Chester Environmental, Moon Township, PA (United States)

1995-12-31

440

Conedy: a scientific tool to investigate complex network dynamics.  

PubMed

We present Conedy, a performant scientific tool to numerically investigate dynamics on complex networks. Conedy allows to create networks and provides automatic code generation and compilation to ensure performant treatment of arbitrary node dynamics. Conedy can be interfaced via an internal script interpreter or via a Python module. PMID:22463001

Rothkegel, Alexander; Lehnertz, Klaus

2012-03-01

441

Complexes of stars and complexes of star clusters  

E-print Network

Most star complexes are in fact complexes of stars, clusters and gas clouds; term "star complexes" was introduced as general one disregarding the preferential content of a complex. Generally the high rate of star formation in a complex is accompanied by the high number of bound clusters, including massive ones, what was explained by the high gas pressure in such regions. However, there are also complexes, where clusters seems to be more numerous in relation to stars than in a common complex. The high rate of clusters - but not isolated stars - formation seems to be typical for many isolated bursts of star formation, but deficit of stars might be still explained by the observational selection. The latter cannot, however, explain the complexes or the dwarf galaxies, where the high formation rate of only stars is observed. The possibility of the very fast dissolution of parental clusters just in such regions should itself be explained. Some difference in the physical conditions (turbulence parameters ?) within the initial gas supercloud might be a reason for the high or low stars/clusters number ratio in a complex.

Yuri N. Efremov

2005-12-12

442

Fact Sheet: Range Complex  

NASA Technical Reports Server (NTRS)

NASA Ames has a long tradition in leadership with the use of ballistic ranges and shock tubes for the purpose of studying the physics and phenomena associated with hypervelocity flight. Cutting-edge areas of research run the gamut from aerodynamics, to impact physics, to flow-field structure and chemistry. This legacy of testing began in the NACA era of the 1940's with the Supersonic Free Flight Tunnel, and evolved dramatically up through the late 1950s with the pioneering work in the Ames Hypersonic Ballistic Range. The tradition continued in the mid-60s with the commissioning of the three newest facilities: the Ames Vertical Gun Range (AVGR) in 1964, the Hypervelocity Free Flight Facility (HFFF) in 1965 and the Electric Arc Shock Tube (EAST) in 1966. Today the Range Complex continues to provide unique and critical testing in support of the Nation's programs for planetary geology and geophysics; exobiology; solar system origins; earth atmospheric entry, planetary entry, and aerobraking vehicles; and various configurations for supersonic and hypersonic aircraft.

Cornelson, C.; Fretter, E.

2004-01-01

443

Information Complexity and Biology  

NASA Astrophysics Data System (ADS)

Kolmogorov contributed directly to Biology in essentially three problems: the analysis of population dynamics (Lotka-Volterra equations), the reaction-diffusion formulation of gene spreading (FKPP equation), and some discussions about Mendel's laws. However, the widely recognized importance of his contribution arises from his work on algorithmic complexity. In fact, the limited direct intervention in Biology reflects the generally slow growth of interest of mathematicians towards biological issues. From the early work of Vito Volterra on species competition, to the slow growth of dynamical systems theory, contributions to the study of matter and the physiology of the nervous system, the first 50-60 years have witnessed important contributions, but as scattered pieces apparently uncorrelated, and in branches often far away from Biology. Up to the 40' it is hard to see the initial loose build up of a convergence, for those theories that will become mainstream research by the end of the century, and connected by the study of biological systems per-se.

Bagnoli, Franco; Bignone, Franco A.; Cecconi, Fabio; Politi, Antonio

444

Preparation and Structural Properties of InIII-H Complexes  

PubMed Central

The use of the tripodal ligands tris[(N'-tert-butylureaylato)-N-ethyl]aminato ([H3buea]3?) and the sulfonamide-based N,N',N"-[2,2',2"-nitrilotris(ethane-2,1-diyl)]tris(2,4,6-trimethylbenzene-sulfonamidato) ([MST]3?) has led to the synthesis of two structurally distinct In(III)–OH complexes. The first example of a five-coordinate indium(III) complex with a terminal hydroxide ligand, K[InIIIH3buea(OH)], was prepared by addition of In(OAc)3 and water to a deprotonated solution of H6buea. X-ray diffraction analysis, as well as FTIR and 1H NMR spectroscopic methods, provided evidence for the formation of a monomeric In(III)–OH complex. The complex contains an intramolecular hydrogen bonding (H-bonding) network involving the In(III)–OH unit and [H3buea]3? ligand, which aided in isolation of the complex. Isotope labeling studies verified the source of the hydroxo ligand as water. Treatment of the [InIIIMST] complex with a mixture of 15-crown-5 ether and NaOH led to isolation of the complex [15-crown-5?NaI-(?-OH)-InIIIMST], whose solid-state structure was confirmed using X-ray diffraction methods. Nuclear magnetic resonance studies on this complex suggest it retains its heterobimetallic structure in solution. PMID:25309019

Sickerman, Nathaniel S.; Henry, Renee M.; Ziller, Joseph W.

2013-01-01

445

Wastewater treatment of pulp and paper industry: a review.  

PubMed

Pulp and paper industries generate varieties of complex organic and inorganic pollutants depending upon the type of the pulping process. A state-of-art of treatment processes and efficiencies of various wastewater treatment is presented and critically reviewed in this paper. Process description, source of wastewater and their treatment is discussed in detail. Main emphasis is given to aerobic and anaerobic wastewater treatment. In pulp and paper mill wastewater treatment aerobic treatment includes activated sludge process, aerated lagoons and aerobic biological reactors. UASB, fluidized bed, anaerobic lagoon and anaerobic contact reactors are the main technologies for anaerobic wastewater treatment. It is found that the combination of anaerobic and aerobic treatment processes is much efficient in the removal of soluble biodegradable organic pollutants. Color can be removed effectively by fungal treatment, coagulation, chemical oxidation, and ozonation. Chlorinated phenolic compounds and adsorable organic halides (AOX) can be efficiently reduced by adsorption, ozonation and membrane filtration techniques. PMID:23033705

Kansal, Ankur; Siddiqui, Nihalanwar; Gautam, Ashutosh

2011-04-01

446

Complexity regularized hydrological model selection  

NASA Astrophysics Data System (ADS)

Ill-posed hydrological model selection problems (that may be unstable or have non-unique solutions) are regularized with hydrological model complexity as the stabilizer. We propose and apply a notion of model complexity, based on Vapnik-Chervonenkis generalization theory, to complexity regularized hydrologic model selection. Better hydrologic models (better performance on future unseen data) on small sample sizes are identified using complexity regularized model selection than when using traditional model selection (without regularization) while both converge in performance for large samples (i.e. regulari