Sample records for complex tfcc treatment

  1. [Ulnar-sided wrist pain in sports : TFCC lesions and fractures of the hook of the hamate bone as uncommon diagnosis].

    PubMed

    Plöger, M M; Kabir, K; Friedrich, M J; Welle, K; Burger, C

    2015-06-01

    Injuries to the hand and wrist are common sports injuries. The diagnosis and therapy of wrist injuries are becoming more important, especially in increasingly more popular ball-hitting sports, such as golf, tennis and baseball. Ulnar-sided wrist pain is initially often misdiagnosed and treated as tenosynovitis or tendinitis but tears of the triangular fibrocartilage complex (TFCC) and fractures of the hook of hamate bone, which can also occur in these sports are seldomly diagnosed. The aim of this study was to conduct a systematic review of the literature focussing on TFCC lesions and fractures of the hook of the hamate bone in racquet sports, baseball and golf. A systematic review of the literature was performed in PubMed on the occurrence of TFCC lesions and fractures of the hook of the hamate bone. All studies and case reports were included. Because of the rarity of these injuries there were no exclusion criteria concerning the number of cases. Injuries associated with ball-hitting sports, such as TFCC lesions and fractures of hook of the hamate bone are still underrepresented in the current literature on sports injuries. The diagnosis and treatment of these injuries are often delayed and can severely handicap the performance and career of affected professional as well as amateur athletes. PMID:25956726

  2. Anatomic foveal reconstruction of the triangular fibrocartilage complex with a tendon graft.

    PubMed

    Bain, Gregory I; McGuire, Duncan; Lee, Yu Chao; Eng, Kevin; Zumstein, Matthias

    2014-06-01

    An acute injury to the triangular fibrocartilage complex (TFCC) with avulsion of the foveal attachment can produce distal radioulnar joint (DRUJ) instability. The avulsed TFCC is translated distally so the footprint will be bathed in synovial fluid from the DRUJ and will become covered in synovitis. If the TFCC fails to heal to the footprint, then persistent instability can occur. The authors describe a surgical technique indicated for the treatment of persistent instability of the DRUJ due to foveal detachment of the TFCC. The procedure utilizes a loop of palmaris longus tendon graft passed through the ulnar aspect of the TFCC and into an osseous tunnel in the distal ulna to reconstruct the foveal attachment. This technique provides stability of the distal ulna to the radius and carpus. We recommend this procedure for chronic instability of the DRUJ due to TFCC avulsion, but recommend that suture repair remain the treatment of choice for acute instability. An arthroscopic assessment includes the trampoline test, hook test, and reverse hook test. DRUJ ballottement under arthroscopic vision details the direction of instability, the functional tear pattern, and unmasks concealed tears. If the reverse hook test demonstrates a functional instability between the TFCC and the radius, then a foveal reconstruction is contraindicated, and a reconstruction that stabilizes the radial and ulnar aspects of the TFCC is required. The foveal reconstruction technique has the advantage of providing a robust anatomically based reconstruction of the TFCC to the fovea, which stabilizes the DRUJ and the ulnocarpal sag. PMID:24694387

  3. Wrist arthroscopy for the treatment of ligament and triangular fibrocartilage complex injuries

    Microsoft Academic Search

    JG Westkaemper; G Mitsionis; PN Giannakopoulos; DG Sotereanos

    1998-01-01

    The use of arthroscopy was evaluated in 47 patients who were treated for suspected triangular fibrocartilage complex (TFCC) tears, scapholunate (SL) tears, and\\/or lunotriquetral (LT) tears. Wrist arthroscopy was performed using traction and standard portals. Any TFCC tear found was debrided to a stable rim. SL and LT tears were debrided to bleeding bone. The range of follow-up was 1.5

  4. Revision Wrist Arthroscopy after Failed Primary Arthroscopic Treatment

    PubMed Central

    Jang, Eugene; Danoff, Jonathan R.; Rajfer, Rebecca A.; Rosenwasser, Melvin P.

    2014-01-01

    Background?The etiologies and outcomes of cases of failed therapeutic wrist arthroscopy have not been well-described to date. Purpose?The purposes of this study were to identify common preventable patterns of failure in wrist arthroscopy and to report outcomes of a series of revision arthroscopy cases. Patients and Methods?Retrospective review of 237 wrist arthroscopies revealed 21 patients with a prior arthroscopy for the same symptoms, of which 16 were assessed by questionnaires and physical exam for this study. Results?Six of sixteen patients (38%) had unrecognized dynamic ulnar impaction after débridement of triangular fibrocartilage complex (TFCC) tears, which resolved with arthroscopic wafer resection. Five (31%) had persistent distal radioulnar joint (DRUJ) instability after initial treatment of TFCC tears, requiring arthroscopic repair at revision. Four (25%) experienced diffuse dorsal wrist pain initially diagnosed as TFCC tears, but dynamic scapholunate ligament injuries were found and addressed with radiofrequency (RF) shrinkage at reoperation. Two (13%) required further resection of the radial styloid, after initial débridement was insufficient to correct radioscaphoid impingement. At a mean of 4.8 years after repeat arthroscopy (range, 1.5–13.4 years), this cohort had significant improvements in pain and satisfaction with outcomes after revision arthroscopy. Conclusions?The most common indications for repeat wrist arthroscopy were ligamentous instability (of the DRUJ or scapholunate ligament) and osteoarthritis (from dynamic ulnar impaction or radioscaphoid impingement). Although revision wrist arthroscopy may yield acceptable outcomes, careful assessment of stability and cartilage wear at index procedure is crucial. Level of Evidence:?Level IV Therapeutic. PMID:24533243

  5. Complexity in Language Learning and Treatment

    ERIC Educational Resources Information Center

    Thompson, Cynthia K.

    2007-01-01

    Purpose: To introduce a Clinical Forum focused on the Complexity Account of Treatment Efficacy (C. K. Thompson, L. P. Shapiro, S. Kiran, & J. Sobecks, 2003), a counterintuitive but effective approach for treating language disorders. This approach espouses training "complex" structures to promote generalized improvement of simpler, linguistically…

  6. Multifunctional carbon nanohorn complexes for cancer treatment.

    PubMed

    Chechetka, Svetlana A; Pichon, Benoit; Zhang, Minfang; Yudasaka, Masako; Bégin-Colin, Sylvie; Bianco, Alberto; Miyako, Eijiro

    2015-01-01

    Multifunctional carbon nanohorn (CNH) complexes were synthesized using oxidized CNH, magnetite (MAG) nanoparticles, and polyethyleneimine (PEI). The ferromagnetic MAG nanoparticles were loaded onto CNH (MAG-CNH) using iron(II) acetate and subsequent heat treatment. Chemical functionalization of the MAG-CNH complexes with PEI improved their water-dispersibility and allowed further conjugation with a fluorophore. The application of an external magnetic field significantly intensified the targeted vectorization of CNH complexes into human cervical cancer (HeLa) cells. Following cell uptake, laser irradiation of the cells showed a significant enhancement in the photothermal effects of CNHs leading to cell death. We have confirmed that the photothermal properties and ferromagnetic characteristics of CNH complexes show efficient cell elimination. The present study is an essential step toward the development of an innovative cancer therapy and a highly sensitive detection of cancer cells at the single-cell level. PMID:25319234

  7. Complex renal cysts associated with crizotinib treatment

    PubMed Central

    Schnell, Patrick; Bartlett, Cynthia H; Solomon, Benjamin J; Tassell, Vanessa; Shaw, Alice T; de Pas, Tommaso; Lee, Soo-Hyun; Lee, Geon Kook; Tanaka, Kaoru; Tan, Weiwei; Tang, Yiyun; Wilner, Keith D; Safferman, Allan; Han, Ji-Youn

    2015-01-01

    An apparent causal association between crizotinib treatment and renal cyst development emerged during clinical trials in anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer (NSCLC). Serious adverse event (SAE) reports of renal cysts from a safety database of 1375 patients from four clinical trials were reviewed. A blinded, retrospective, independent radiologic review (IRR) was performed using scans from patients on study for ?6 months in three clinical trials; risk factors for renal cyst development were assessed. Among 17 patients with renal cysts reported as SAEs, evidence of invasion into adjacent structures was noted in seven patients, with no evidence of malignancy found. These patients generally did not require dose reductions, none required permanent crizotinib discontinuation due to this AE, and most continued treatment with clinical benefit. In the blinded IRR, among 255 crizotinib-treated patients, 22%, 3%, and 2% had preexisting simple cysts, complex cysts, or both, respectively. At the 6-month tumor assessment, 9% of all patients had acquired new cysts, and 2% of patients with preexisting cysts had developed new cysts and enlargements (>50%) of preexisting simple cysts. Asians appeared to have an increased risk of developing new cysts on treatment; Koreans in particular had 5.18 times higher odds of developing cysts than non-Asians (95% confidence interval, 1.51–17.78; P = 0.05). Crizotinib treatment appears to be associated with an increased risk of development and progression of renal cysts in patients with ALK-positive NSCLC. While close monitoring is recommended, dosing modification was not generally necessary, allowing patients to remain on crizotinib treatment. PMID:25756473

  8. Treatment definition in complex rehabilitation interventions

    Microsoft Academic Search

    Tessa Hart

    2009-01-01

    Rehabilitation research is challenged to improve its evidence base, which requires more precise and more consistent conceptualisation and measurement of treatment ingredients. This paper presents the steps in defining and specifying treatments towards the construction of a therapy manual for experimental interventions, or a coding system for observational treatment research. Specifying the active ingredients, identifying the behavioural operations that are

  9. 12. NORTHEAST VIEW OF THE WASTE WATER TREATMENT COMPLEX FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. NORTHEAST VIEW OF THE WASTE WATER TREATMENT COMPLEX FOR THE PRIMARY AND 22 BAR MILLS. - U.S. Steel Duquesne Works, Auxiliary Buildings & Shops, Along Monongahela River, Duquesne, Allegheny County, PA

  10. The impact of treatment complexity and computer-control delivery technology on treatment delivery errors

    Microsoft Academic Search

    Benedick A Fraass; Kathy L Lash; Gwynne M Matrone; Susan K Volkman; Daniel L McShan; Marc L Kessler; Allen S Lichter

    1998-01-01

    Purpose: To analyze treatment delivery errors for three-dimensional (3D) conformal therapy performed at various levels of treatment delivery automation and complexity, ranging from manual field setup to virtually complete computer-controlled treatment delivery using a computer-controlled conformal radiotherapy system (CCRS).Methods and Materials: All treatment delivery errors which occurred in our department during a 15-month period were analyzed. Approximately 34,000 treatment sessions

  11. Are English treatment centres treating less complex patients?

    Microsoft Academic Search

    Peter Sivey; Anne Mason; Marisa Miraldo; Luigi Siciliani

    2010-01-01

    Activity-based funding involves remunerating healthcare providers a fixed price per patient in each payment category. However, no categorisation system can account perfectly for differences in patient complexity. Differences may be systematic if providers routinely attract high-risk patients or engage in patient selection. Such differences may be evident in the English National Health Service (NHS) following the introduction of treatment centres

  12. 76 FR 39110 - Medicare Program; Section 3113: The Treatment of Certain Complex Diagnostic Laboratory Tests...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ...Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration AGENCY: Centers...Treatment of Certain Complex Diagnostic Laboratory Tests Demonstration. The Demonstration...3113 for being a complex diagnostic laboratory test under the Demonstration. The...

  13. [Principles of complex treatment of infection in emergency surgery].

    PubMed

    Kavkalo, D N

    1991-01-01

    The analysis of 140 cases of acute surgical sepsis is presented. The general principles for the treatment of sepsis in emergency surgery were established. The most effective are the guided laparotomy in peritoneal sepsis, use of intravascular laser blood irradiation, chemotherapeutical means and dressing materials (polysorb, carboserix, collocyl etc.), different gaseous media (aeroionotherapy, oxygenation, ozonized guided antibacterial medium) which have favourable effect on the reparative processes in the primary foci of infection. Resulting from the use of complex treatment, the decrease in lethality from 75 to 35.7% was noted. PMID:1881081

  14. Understanding treatment decision making: Contexts, commonalities, complexities, and challenges

    Microsoft Academic Search

    Thomas Blank; Kristi Graves; Karen Sepucha; Hilary Llewellyn-Thomas

    2006-01-01

    Background: The diagnosis of cancer sets off a cascade of complex decisions at a time when patients feel vulnerable and distressed.\\u000a Although clinical decisions used to follow one standard, many guidelines now outline several options and include explicit\\u000a recognition of the need to incorporate patients’ preferences to determine the most appropriate treatment.Purpose: The purpose of this article is to provide

  15. Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder

    PubMed Central

    Fountoulakis, Konstantinos N; Vieta, Eduard; Siamouli, Melina; Valenti, Marc; Magiria, Stamatia; Oral, Timucin; Fresno, David; Giannakopoulos, Panteleimon; Kaprinis, George S

    2007-01-01

    Background Manic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment. Methods This article summarizes the current status of our knowledge and practice of its treatment. Results It is widely accepted that lithium is moderately useful during all phases of bipolar illness and it might possess a specific effectiveness on suicidal prevention. Both first and second generation antipsychotics are widely used and the FDA has approved olanzapine, risperidone, quetiapine, ziprasidone and aripiprazole for the treatment of acute mania. These could also be useful in the treatment of bipolar depression, but only limited data exists so far to support the use of quetiapine monotherapy or the olanzapine-fluoxetine combination. Some, but not all, anticonvulsants possess a broad spectrum of effectiveness, including mixed dysphoric and rapid-cycling forms. Lamotrigine may be effective in the treatment of depression but not mania. Antidepressant use is controversial. Guidelines suggest their cautious use in combination with an antimanic agent, because they are supposed to induce switching to mania or hypomania, mixed episodes and rapid cycling. Conclusion The first-line psychosocial intervention in BD is psychoeducation, followed by cognitive-behavioral therapy. Other treatment options include Electroconvulsive therapy and transcranial magnetic stimulation. There is a gap between the evidence base, which comes mostly from monotherapy trials, and clinical practice, where complex treatment regimens are the rule. PMID:17925035

  16. Multidrug-Resistant Tuberculosis Treatment Outcomes in Karakalpakstan, Uzbekistan: Treatment Complexity and XDR-TB among Treatment Failures

    PubMed Central

    Cox, Helen S.; Kalon, Stobdan; Allamuratova, Sholpan; Sizaire, Vinciane; Tigay, Zinaida N.; Rüsch-Gerdes, Sabine; Karimovich, Hamraev A.; Kebede, Yared; Mills, Clair

    2007-01-01

    Background A pilot programme to treat multidrug-resistant TB (MDR-TB) was implemented in Karakalpakstan, Uzbekistan in 2003. This region has particularly high levels of MDR-TB, with 13% and 40% among new and previously treated cases, respectively. Methodology This study describes the treatment process and outcomes for the first cohort of patients enrolled in the programme, between October 2003 and January 2005. Confirmed MDR-TB cases were treated with an individualised, second-line drug regimen based on drug susceptibility test results, while suspected MDR-TB cases were treated with a standardised regimen pending susceptibility results. Principal Findings Of 108 MDR-TB patients, 87 were started on treatment during the study period. Of these, 33 (38%) were infected with strains resistant to at least one second-line drug at baseline, but none had initial ofloxacin resistance. Treatment was successful for 54 (62%) patients, with 13 (15%) dying during treatment, 12 (14%) defaulting and 8 (8%) failing treatment. Poor clinical condition and baseline second-line resistance contributed to treatment failure or death. Treatment regimens were changed in 71 (82%) patients due to severe adverse events or drug resistance. Adverse events were most commonly attributed to cycloserine, ethionamide and p-aminosalicylic acid. Extensively drug resistant TB (XDR-TB) was found among 4 of the 6 patients who failed treatment and were still alive in November 2006. Conclusions While acceptable treatment success was achieved, the complexity of treatment and the development of XDR-TB among treatment failures are important issues to be addressed when considering scaling up MDR-TB treatment. PMID:17987113

  17. Potential for treatment of severe autism in tuberous sclerosis complex

    PubMed Central

    Gipson, Tanjala T; Gerner, Gwendolyn; Wilson, Mary Ann; Blue, Mary E; Johnston, Michael V

    2013-01-01

    The Food and Drug Administration (FDA) has approved two mechanism-based treatments for tuberous sclerosis complex (TSC)-everolimus and vigabatrin. However, these treatments have not been systematically studied in individuals with TSC and severe autism. The aim of this review is to identify the clinical features of severe autism in TSC, applicable preclinical models, and potential barriers that may warrant strategic planning in the design phase of clinical trial development. A comprehensive search strategy was formed and searched across PubMed, Embase and SCOPUS from their inception to 2/21/12, 3/16/12, and 3/12/12 respectively. After the final search date, relevant, updated articles were selected from PubMed abstracts generated electronically and emailed daily from PubMed. The references of selected articles were searched, and relevant articles were selected. A search of clinicaltrials.gov was completed using the search term “TSC” and “tuberous sclerosis complex”. Autism has been reported in as many as 60% of individuals with TSC; however, review of the literature revealed few data to support clear classification of the severity of autism in TSC. Variability was identified in the diagnostic approach, assessment of cognition, and functional outcome among the reviewed studies and case reports. Objective outcome measures were not used in many early studies; however, diffusion tensor imaging of white matter, neurophysiologic variability in infantile spasms, and cortical tuber subcategories were examined in recent studies and may be useful for objective classification of TSC in future studies. Mechanism-based treatments for TSC are currently available. However, this literature review revealed two potential barriers to successful design and implementation of clinical trials in individuals with severe autism-an unclear definition of the population and lack of validated outcome measures. Recent studies of objective outcome measures in TSC and further study of applicable preclinical models present an opportunity to overcome these barriers. PMID:25254170

  18. Optimal treatment of multivessel complex coronary artery disease

    PubMed Central

    SUN, HAIHUI; CUI, LIANQUN

    2014-01-01

    The aim of the present study was to investigate major cardiac events and the similarities and differences of medical costs among patients with multivessel complex coronary artery disease (MCCAD) during the three-year follow-up. The MCCAD patients had undergone single complete revascularization (CR), fractionated revascularization (FR) or partial revascularization (PR) and the present study aimed to screen the optimal treatment program. A total of 2,309 MCCAD patients who had been treated at a single center in the last decade, among which 1,020 cases underwent single CR, 856 cases successively underwent FR and 433 cases only underwent PR, were followed-up for three years. Major cardiac events, including all-cause mortality, myocardial infarction, severe heart failure, rehospitalization and revascularization (coronary artery bypass grafting and coronary stent reimplantation), were set as the end points. In addition, the three-year medical costs associated with heart disease were analyzed. The three-year cardiac event rate in the CR group (17%) was significantly lower compared with the other two groups and the average three-year medical costs in the CR group (62,100 RMB) were significantly lower than those in the other two groups. Therefore, under permissive conditions, single CR is the optimal and most economical treatment strategy for patients with MCCAD. PMID:24926344

  19. Analytical Treatment of Coherent Excitation Transfer in FMO Complex

    E-print Network

    Pallavi Bhattacharyya; K. L. Sebastian

    2013-06-06

    We suggest a new method of studying coherence in finite level systems coupled to the environment and use it for the Hamiltonian that has been used to describe the light-harvesting pigment-protein complex. The method works with the adiabatic states and transforms the Hamiltonian to a form in which the terms responsible for decoherence and population relaxation are separated out. Decoherence is then accounted for non-perturbatively, and population relaxation using a Markovian master equation. Analytical results can be obtained for the seven level system and the calculations are very simple for systems with more levels. We apply the treatment to the seven level system and the results are in excellent agreement with the exact numerical results of Nalbach et al. (P. Nalbach, D. Braun, and M. Thorwart, Physical Review E, 84, 041926 (2011)). Our approach is able to account for decoherence and population relaxation separately. It is found that decoherence only causes damping of oscillations, and does not lead to transfer to the reaction centre. Population relaxation is necessary for efficient transfer to the reaction centre, in agreement with earlier findings. Our results show that the transformation to the adiabatic basis followed by a Redfield type of approach leads to results in good agreement with exact simulation.

  20. Dosimetry and treatment planning of complex electron arc therapy

    Microsoft Academic Search

    Matt Tobler; Dennis D. Leavitt; John K. Hayes

    1995-01-01

    Electron are therapy has been primarily utilized for treatment of the post-mastectomy chest wall. Its clinical usefulness and benefits have been proven. Casting procedures and blocking techniques have been discussed. We have successfully applied electron are therapy to the treatment of the nasal cavity and associated nodal regions. When compared to the chest wall, the smaller radii and pronounced irregularity

  1. Boundary treatments for 2D elliptic mesh generation in complex geometries

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper presents a boundary treatment method for 2D elliptic mesh generation in complex geometries. Corresponding to Neumann- Dirichlet boundary conditions (sliding boundary conditions), the proposed method aims at achieving orthogonal and smooth nodal distribution along irregular boundaries. In ...

  2. Comparison of Chemical Composition of Complex Disinfection Byproduct (DBP) Mixtures Produced by Different Treatment Methods - slides

    EPA Science Inventory

    Analyses of the chemical composition of complex DBP mixtures, produced by different drinking water treatment processes, are essential to generate toxicity data required for assessing their risks to humans. For mixture risk assessments, whole mixture toxicology studies generally a...

  3. Comparison of Chemical Composition of Complex Disinfection Byproduct (DBP) Mixtures Produced by Different Treatment Methods

    EPA Science Inventory

    Analyses of the chemical composition of complex DBP mixtures, produced by different drinking water treatment processes, are essential to generate toxicity data required for assessing their risks to humans. For mixture risk assessments, whole mixture toxicology studies generally a...

  4. Cyclodextrin complexes for treatment improvement in infectious diseases.

    PubMed

    Imperiale, Julieta C; Sosnik, Alejandro D

    2015-05-01

    Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented. PMID:26008196

  5. Platinum coil treatment of complex aneurysms of the vertebrobasilar circulation

    Microsoft Academic Search

    Y. Numaguchi; P. H. Pevsner; D. Rigamonti; J. Ragheb

    1992-01-01

    Two patients with complex aneurysms of the vertebrobasilar system were treated using platinum coils. During these sessions, 22 coils were placed in a basilar tip aneurysm in a 48-year-old woman. Almost total occlusion of the lumen was achieved, excepted in the area from which the right posterior cerebral artery arose. A large fusiform vertebral artery aneurysm in a 6-year-old boy

  6. Effective Treatment of Complex Post Traumatic Stress Disorder and Early Attachment Trauma

    Microsoft Academic Search

    Emily R Murphrey

    2011-01-01

    Research on and disagreements regarding the appropriate treatments for various types of traumas have existed throughout the history of psychotherapy. While approaches have differed over the years, current research suggests that prolonged exposure therapy, long considered the most efficacious treatment for single incident trauma, may be at best ineffectual for treating the condition known as Complex Post Traumatic Stress Disorder,

  7. A Uniform-Complexity Treatment of Encryption and Zero-Knowledge

    Microsoft Academic Search

    Oded Goldreich

    1993-01-01

    We provide a treatment of encryption and zero-knowledge in terms of uniform complexitymeasures. This treatment is appropriate for cryptographic settings modeled by probabilisticpolynomial-time machines. Our uniform treatment allows to construct secure encryptionschemes and zero-knowledge proof systems (for all I NP) using only uniform complexity assumptions.We show that uniform variants of the two definitions of security, presented in the pioneeringwork of

  8. Passive Treatment of Acidic Coal Mine Drainage: The Anna S Mine Passive Treatment Complex

    Microsoft Academic Search

    Robert Hedin; Ted Weaver; Neil Wolfe; Kimberly Weaver

    2010-01-01

    The Anna S coal mine complex in Tioga County, PA, produces drainage with a pH of 2.8–3.6 containing 3–36 mg\\/L Al, 1–36 mg\\/L\\u000a Fe, and 6–9 mg\\/L Mn. In 2003, the Babb Creek Watershed Association installed two systems that passively treat three discharges\\u000a from the mine complex. Both systems contain four parallel vertical flow ponds followed by aerobic wetlands. The vertical flow\\u000a ponds

  9. Photodynamic Antimicrobial Chemotherapy (PACT) in combination with antibiotics for treatment of Burkholderia cepacia complex infection

    Microsoft Academic Search

    Corona M. Cassidy; Ryan F. Donnelly; J. Stuart Elborn; Nicholas D. Magee; Michael M. Tunney

    This study aimed to determine if Photodynamic Antimicrobial Chemotherapy (PACT) was effective in the treatment of Burkholderia cepacia complex infection and whether a synergistic effect was evident if PACT was used in combination with antibiotics. The susceptibility of both planktonic and biofilm cultures of B. cepacia complex strains to methylene blue (MB) and meso-tetra(n-methyl-4-pyridyl)porphine tetra-tosylate (TMP)–mediated PACT was determined alone

  10. The use of imagery in phase 1 treatment of clients with complex dissociative disorders

    PubMed Central

    van der Hart, Onno

    2012-01-01

    The “standard of care” for clients with complex dissociative disorders and other complex trauma-related disorders is phase-oriented treatment. Within this frame, therapeutic progress can be enhanced by the use of imagery-based therapeutic techniques. In this article, the emphasis is on their application in phase 1 treatment, stabilization, symptom reduction, and skills training, but attention is also paid to applications in phase 2 and phase 3 treatment. Many of the existing imagery techniques are geared toward clients becoming more able to function in a more adaptive way in daily life, which, however, requires the involvement of various dissociative parts of the personality. Such collaborative involvement is also essential in the later treatment phases. Therefore, understanding the dissociative nature of these disorders is helpful in the judicious application of these techniques. PMID:22893843

  11. Laser therapy and phototherapy in complex treatment of children's oncological diseases

    NASA Astrophysics Data System (ADS)

    Tsigankin, V. I.; Balakirev, S. A.; Atroshchenko, V. I.; Belousov, N. N.; Ivanov, Andrei V.

    1996-01-01

    The application of the laser therapy and phototherapy with utilization of High Intensive Impulse Laser Therapeutic Unit and High Intensive Impulse Light Therapeutic Unit has created new side prospects in treatment of side-effects and complications when treating oncological diseases and a great number of non-tumoral diseases of adults as well as children. The application of the laser therapy and phototherapy in complex treatment of children's oncological diseases has shown that this method has a significant antiinflammatory and anaesthetic effect as well as powerful regenerative influence on tissues. Its application decreases considerably the duration of treatment of complications when treating children's malignant tumors and enables to keep to scheduled terms of complex treatment.

  12. [The application of combined physiotherapeutic methods for the complex treatment of patients with dyscirculatory encephalopathy].

    PubMed

    Shiman, A G; Klocheva, E G; Kaiumov, S F; Shoferova, S D; Zhukova, M V

    2012-01-01

    This article reports the results of applying basic pharmacotherapy (enalapril, cytoflavin) and its combination with physical factors (transcranial electrostimulation, combined application oftranscranial electrostimulation and low-frequency magnetic therapy) in the complex treatment of patients with stage I-II dyscirculatory encephalopathy. The study has demonstrated that the combined treatment with cytoflavin, enalapril, transcranial electrostimulation and low-frequency magnetic therapy produced the most pronounced therapeutic effect (82.5%), as confirmed by positive dynamics of clinical and functional parameters. PMID:22908466

  13. Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis.

    PubMed

    Cevher, Erdal; Açma, Ay?e; Sinani, Genada; Aksu, Buket; Zloh, Mire; Mülaz?mo?lu, Lütfiye

    2014-08-01

    Itraconazole (ITR) is commonly used in the treatment of Candida infections. It has a nephrotoxic effect and low bioavailability in patients who suffer from renal insufficiency, and its poor solubility in water makes ITR largely unavailable. Cyclodextrins (CyDs) are used to form inclusion complexes with drugs to improve their aqueous solubility and to reduce their side effects. In this study, ITR was complexed with ?-cyclodextrin (?-CyD), hydroxypropyl-?-cyclodextrin (HP-?-CyD), methyl-?-cyclodextrin (Met-?-CyD) and sulphobutyl ether-?-cyclodextrin (SBE7-?-CyD) to increase its water solubility and to reduce the side effects of the drug without decreasing antifungal activity. Complex formation between ITR and CyDs was evaluated using SEM, (1)H NMR and XRD studies. The antifungal activity of the complexes was analyzed on Candida albicans strains, and the susceptibility of the strains was found to be higher for the ITR-SBE7-?-CyD complex than for the complexes that were prepared with other CyDs. Vaginal bioadhesive sustained release tablet formulations were developed using the ITR-SBE7-?-CyD inclusion complex to increase the residence time of ITR in the vagina, thereby boosting the efficacy of the treatment. The swelling, matrix erosion and bioadhesion properties of formulations and the drug release rate of these tablets were analyzed, and the most therapeutically effective vaginal formulation was determined. PMID:24857873

  14. Complex Psychiatric Comorbidity of Treatment-Seeking Youth with Autism Spectrum Disorder and Anxiety Symptoms

    ERIC Educational Resources Information Center

    Hepburn, Susan L.; Stern, Jessica A.; Blakeley-Smith, Audrey; Kimel, Lila K.; Reaven, Judith A.

    2014-01-01

    This descriptive study examines the complexity of psychiatric comorbidity in treatment-seeking youth with ASD and anxiety symptoms. Forty-two parents of youth with ASD and anxiety (ages 8-14) completed a structured diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version). Youth…

  15. Complex treatment of trophic affections with vascular patients using monochromatic red light and hyperbaric oxygenation

    NASA Astrophysics Data System (ADS)

    Babkina, Zinaida M.; Vasilyev, Mikhail V.; Zakharov, Vyacheslav P.; Nikolayev, Viktor V.; Babkin, Vasily I.; Samoday, Valery G.; Zon, Boris A.; Pakhomov, Gennady V.; Naskidashvili, Vasily I.; Kumin, Anatoly A.

    1996-11-01

    Monochromatic red light irradiation therapy of trophic skin affections with vascular patients permits to receive positive results with small wounds. A combination of monochromatic red light and hyperbaric oxygenation is most perspective when conducting a complex therapy of trophic wounds not more than 40 mm2 and allows to diminish time of treatment almost two times.

  16. Anaerobic filter reactor performance for the treatment of complex dairy wastewater at industrial scale

    Microsoft Academic Search

    Francisco Omil; Juan M Garrido; Belén Arrojo; Ramón Méndez

    2003-01-01

    The wastewaters discharged by raw milk quality control laboratories are more complex than the ones commonly generated by dairy factories because of the presence of certain chemicals such as sodium azide or chloramphenicol, which are used for preserving milk before analysis. The treatment of these effluents has been carried out in a full-scale plant comprising a 12m3 anaerobic filter (AF)

  17. The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy

    PubMed Central

    Marshall, Jamie L.; Kwok, Yukwah; McMorran, Brian; Baum, Linda G.; Crosbie-Watson, Rachelle H.

    2013-01-01

    Three adhesion complexes span the sarcolemma and facilitate critical connections between the extracellular matrix and the actin cytoskeleton: the dystrophin- and utrophin-glycoprotein complexes and ?7?1 integrin. Loss of individual protein components results in a loss of the entire protein complex and muscular dystrophy. Muscular dystrophy is a progressive, lethal wasting disease characterized by repetitive cycles of myofiber degeneration and regeneration. Protein replacement therapy offers a promising approach for the treatment of muscular dystrophy. Recently, we demonstrated that sarcospan facilitates protein-protein interactions amongst the adhesion complexes and is an important therapeutic target. Here, we review current protein replacement strategies, discuss the potential benefits of sarcospan expression, and identify important experiments that must be addressed for sarcospan to move to the clinic. PMID:23601082

  18. Everolimus Treatment for an Early Infantile Subependymal Giant Cell Astrocytoma With Tuberous Sclerosis Complex.

    PubMed

    Fukumura, Shinobu; Watanabe, Toshihide; Takayama, Rumiko; Minagawa, Kimio; Tsutsumi, Hiroyuki

    2014-08-19

    Subependymal giant cell astrocytomas are benign tumors often observed with tuberous sclerosis complex. These tumors are rarely diagnosed during fetal life or early infancy. Until recently, the only available treatment has been surgical resection. Current clinical research has demonstrated that everolimus can induce these tumors' regression. We report a 19-month-old boy with tuberous sclerosis complex. At 2 months of age, he presented with congenital subependymal giant cell astrocytoma that was complicated by refractory epilepsy and severe mental retardation. Treatment with everolimus was started when he was 10 months old. Three months after initiating everolimus, the tumor was significantly reduced in size, and the reduction was subsequently maintained. His seizures decreased and he showed cognitive and developmental improvement. No severe adverse events have been observed to date. Everolimus has promise as an effective alternative to surgery for subependymal giant cell astrocytomas during early infancy. PMID:25143481

  19. Factors that lessen the burden of treatment in complex patients with chronic conditions: a qualitative study

    PubMed Central

    Ridgeway, Jennifer L; Egginton, Jason S; Tiedje, Kristina; Linzer, Mark; Boehm, Deborah; Poplau, Sara; de Oliveira, Djenane Ramalho; Odell, Laura; Montori, Victor M; Eton, David T

    2014-01-01

    Purpose Patients with multiple chronic conditions (multimorbidity) often require ongoing treatment and complex self-care. This workload and its impact on patient functioning and well-being are, together, known as treatment burden. This study reports on factors that patients with multimorbidity draw on to lessen perceptions of treatment burden. Patients and methods Interviews (n=50) and focus groups (n=4 groups, five to eight participants per group) were conducted with patients receiving care in a large academic medical center or an urban safety-net hospital. Interview data were analyzed using qualitative framework analysis methods, and themes and subthemes were used to identify factors that mitigate burden. Focus groups were held to confirm these findings and clarify any new issues. This study was part of a larger program to develop a patient-reported measure of treatment burden. Results Five major themes emerged from the interview data. These included: 1) problem-focused strategies, like routinizing self-care, enlisting support of others, planning for the future, and using technology; 2) emotion-focused coping strategies, like maintaining a positive attitude, focusing on other life priorities, and spirituality/faith; 3) questioning the notion of treatment burden as a function of adapting to self-care and comparing oneself to others; 4) social support (informational, tangible, and emotional assistance); and 5) positive aspects of health care, like coordination of care and beneficial relationships with providers. Additional subthemes arising from focus groups included preserving autonomy/independence and being proactive with providers. Conclusion Patients attempt to lessen the experience of treatment burden using a variety of personal, social, and health care resources. Assessing these factors in tandem with patient perceptions of treatment burden can provide a more complete picture of how patients fit complex self-care into their daily lives. PMID:24672228

  20. GHOST Protocol: Greatest Healing Opportunity for Soft Tissue, a Treatment Paradigm for Complex Sarcoma Reconstruction.

    PubMed

    Kobraei, Edward M; Eberlin, Kyle R; Ricci, Joseph A; Reish, Richard G; Winograd, Jonathan M; Cetrulo, Curtis L

    2015-06-01

    Modern sarcoma treatment has created new challenges for plastic surgeons. This study was designed to review the recent experience and practice patterns following complex sarcoma resection at a large sarcoma center. All cases from October 2013 to October 2014 involving rare nonepithelial tumors, a multidisciplinary surgical team, radiation and/or chemotherapy treatments, and plastic surgical reconstruction were included in the analysis. In addition to evaluating clinical outcomes, cases were reviewed to identify factors associated with excellent or poor patient care. Review of these cases formed the basis of the greatest healing opportunity for soft tissue (GHOST) protocol. Our patient population included seven males (64%) and four females (36%). All except one patient was exposed to radiotherapy, chemotherapy, or some combination. Diverse procedures were used for reconstruction. Early complications occurred in two patients (18%), and late complications in four patients (36%). Sarcoma resection was found to be highly morbid in our series. Patients with poor preoperative nutritional status were more likely to experience complications postoperatively. The decision to stage a reconstruction was complex and influenced by several factors. Multimodal sarcoma treatments may involve highly morbid procedures and create complex wounds. The GHOST protocol is a useful reference for plastic surgeons. PMID:26031266

  1. [Reflexotherapy combined with cortexin in the complex treatment of speech disorders in patients with cerebral palsy].

    PubMed

    Ukhanova, T A; Gorbunov, F E; Ivanova, V V

    2011-01-01

    Authors studied 78 outpatients with children cerebral palsy, aged from 2 to 7 years, in the children department of neurology and reflexotherapy. All children had speech disorders of different severity: from a severe mental-speech deficit to muscle asinergia of the speech apparatus. Combined microcurrent reflexotherapy (MCRT) in the author's technique and the neuroprotector cortexin were used for treatment. The main group included 40 patients who received the treatment of MCRT in the combination with cortexin, the comparison group consisted of 38 patients who received only MCRT. MCRT consisted of 15 sessions with one month interval after the first treatment and two months after the second one. The treatment with cortexin included sessions of 10 injections each after the end of the first and the third MCRT sessions. Patient state was measured at baseline and at the end of 6 month treatment program. An analysis of results of the complex treatment demonstrated its high efficacy in the recovery of speech functions in children with cerebral palsy compared to patients of the comparison group. PMID:21946134

  2. Lacosamide use in the treatment of refractory epilepsy in tuberous sclerosis complex.

    PubMed

    Geffrey, Alexandra L; Belt, Olivia D; Paolini, Jan L; Thiele, Elizabeth A

    2015-05-01

    Lacosamide (LCS) was approved by the United States Food and Drug Administration (FDA) in 2008 as adjunctive therapy to other anti-epileptic drugs (AEDs) to treat focal-onset seizures, with or without secondary generalization. Its role in the treatment of epilepsy in individuals with tuberous sclerosis complex (TSC) has yet to be determined. This study evaluates LCS treatment of focal-onset refractory epilepsy in patients with TSC. From November 2009 to June 2014, 46 TSC patients followed by a single neurologist were treated with LCS. Forty-eight percent were responders (seizure reduction ?50%). No significant differences between responders and non-responders in demographic characteristics were found. LCS appears to be an effective and safe treatment of refractory focal onset seizures in TSC. Determining the long-term tolerability and efficacy of LCS in TSC patients requires additional clinical experience. PMID:25847341

  3. Treatment of plutonium-bearing solutions: A brief survey of the DOE complex

    SciTech Connect

    Conner, C.; Chamberlain, D.B.; Chen, L.; Vandegrift, G.F.

    1995-03-01

    With the abrupt shutdown of some DOE facilities, a significant volume of in-process material was left in place and still requires treatment for interim storage. Because the systems containing these process streams have deteriorated since shutdown, a portable system for treating the solutions may be useful. A brief survey was made of the DOE complex on the need for a portable treatment system to treat plutonium-bearing solutions. A survey was completed to determine (1) the compositions and volumes of solutions and heels present, (2) the methods that have been used to treat these solutions and heels in the past, and (3) the potential problems that exist in removing and treating these solutions. Based on the surveys and on the Defense Nuclear Facilities Safety Board Recommendation 94-1, design criteria for a portable treatment system were generated.

  4. Treatment for lexical retrieval using abstract and concrete words in persons with aphasia: Effect of complexity

    PubMed Central

    Kiran, Swathi; Sandberg, Chaleece; Abbott, Karen

    2009-01-01

    Background The significance of imageability and concreteness as factors for lexical tasks in aphasic individuals is under debate. No previous treatment studies have looked specifically at training abstract words compared to concrete for improved lexical retrieval in patients with chronic aphasia. Aim The goal of the present study was to determine the efficacy of a treatment for lexical retrieval that is based on models of lexical processing by utilizing abstractness as a mode of complexity. It was hypothesized that training abstract words in a category will result in improvement of those words and generalization to untrained target concrete words in the same category. Training concrete words in a category, however, will result in the retrieval of trained concrete words, but not generalization to target abstract words. Methods & Procedures A single subject experimental design across participants and behaviors was used to examine treatment and generalization. Generative naming for three categories (church, hospital, courthouse) was tested during baseline and treatment. Each treatment session was carried out in five steps: (1) category sorting, (2) feature selection, (3) yes/no feature questions, (4) word recall, and (5) free generative naming. Results Although participant 1 demonstrated neither significant learning nor generalization during abstract or concrete word training, participants 2, 3, and 4 showed significant learning during abstract word training and generalization to untrained concrete words. Participants 3 and 4 were also trained on concrete words which they improved on but did not show generalization to untrained abstract words. Conclusions The results of the present experiment support our hypothesis that training abstract words would result in greater learning and generalization to untrained concrete words. They also tentatively support the idea that generalization is facilitated by treatment focusing on more complex constructions (Kiran & Thompson, 2003; Thompson, Shapiro, Kiran, & Sobecks, 2003). PMID:19816590

  5. Treatment compliance and effectiveness in complex PTSD patients with co-morbid personality disorder undergoing stabilizing cognitive behavioral group treatment: a preliminary study

    PubMed Central

    Dorrepaal, Ethy; Thomaes, Kathleen; Smit, Johannes H.; Veltman, Dick J.; Hoogendoorn, Adriaan W.; van Balkom, Anton J. L. M.; Draijer, Nel

    2013-01-01

    Background In the empirical and clinical literature, complex posttraumatic stress disorder (PTSD) and personality disorders (PDs) are suggested to be predictive of drop-out or reduced treatment effectiveness in trauma-focused PTSD treatment. Objective In this study, we aimed to investigate if personality characteristics would predict treatment compliance and effectiveness in stabilizing complex PTSD treatment. Method In a randomized controlled trial on a 20-week stabilizing group cognitive behavioral treatment (CBT) for child-abuse-related complex PTSD, we included 71 patients of whom 38 were randomized to a psycho-educational and cognitive behavioral stabilizing group treatment. We compared the patients with few PD symptoms (adaptive) (N=14) with the non-adaptive patients (N=24) as revealed by a cluster analysis. Results We found that non-adaptive patients compared to the adaptive patients showed very low drop-out rates. Both non-adaptive patients, classified with highly different personality profiles “withdrawn” and “aggressive,” were equally compliant. With regard to symptom reduction, we found no significant differences between subtypes. Post-hoc, patients with a PD showed lower drop-out rates and higher effect sizes in terms of complex PTSD severity, especially on domains that affect regulation and interpersonal problems. Conclusions Contrary to our expectations, these preliminary findings indicate that this treatment is well tolerated by patients with a variety of personality pathology. Larger sample sizes are needed to study effectiveness for subgroups of complex PTSD patients. PMID:24224077

  6. Amphiphilic Antimony(V) Complexes for Oral Treatment of Visceral Leishmaniasis

    PubMed Central

    Fernandes, Flaviana R.; Ferreira, Weverson A.; Campos, Mariana A.; Ramos, Guilherme S.; Kato, Kelly C.; Almeida, Gregório G.; Corręa, José D.; Melo, Maria N.; Demicheli, Cynthia

    2013-01-01

    The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their potential for the oral treatment of visceral leishmaniasis (VL) was evaluated. Complexes of Sb and ligand at 1:3 (SbL8 and SbL10) were obtained from the reaction of antimony(V) with L8 and L10, as evidenced by elemental and electrospray ionization-tandem mass spectrometry (ESI-MS) analyses. Fluorescence probing of hydrophobic environment and negative-staining transmission electron microscopy showed that SbL8 forms kinetically stabilized nanoassemblies in water. Pharmacokinetic studies with mice in which the compound was administered by the oral route at 200 mg of Sb/kg of body weight indicated that the SbL8 complex promoted greater and more sustained Sb levels in serum and liver than the levels obtained for the conventional antimonial drug meglumine antimoniate (Glucantime [Glu]). The efficacy of SbL8 and SbL10 administered by the oral route was evaluated in BALB/c mice infected with Leishmania infantum after a daily dose of 200 mg of Sb/kg for 20 days. Both complexes promoted significant reduction in the liver and spleen parasite burdens in relation to those in the saline-treated control group. The extent of parasite suppression (>99.96%) was similar to that achieved after Glu given intraperitoneally at 80 mg of Sb/kg/day. As expected, there was no significant reduction in the parasitic load in the group treated orally with Glu at 200 mg of Sb/(kg day). In conclusion, amphiphilic antimony(V) complexes emerge as an innovative and promising strategy for the oral treatment of VL. PMID:23796930

  7. A dual wavelength-activatable gold nanorod complex for synergistic cancer treatment.

    PubMed

    Pacardo, Dennis B; Neupane, Bhanu; Rikard, S Michaela; Lu, Yue; Mo, Ran; Mishra, Sumeet R; Tracy, Joseph B; Wang, Gufeng; Ligler, Frances S; Gu, Zhen

    2015-07-28

    A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy was demonstrated through the synergistic combination of promoted drug release upon ultraviolet (UV) light irradiation and photothermal therapy upon infrared (IR) irradiation. This multifunctional AuNR-based system represents a novel theranostic strategy for spatiotemporal delivery of anticancer therapeutics. PMID:26122945

  8. Treatment of the Atrophic Upper Jaw: Rehabilitation of Two Complex Cases

    PubMed Central

    Borgonovo, Andrea Enrico; Marchetti, Andrea; Vavassori, Virna; Censi, Rachele; Boninsegna, Ramon

    2013-01-01

    In reconstructive surgery, the fresh frozen homologous bone (FFB) represents a valid alternative to the autologous bone, because FFB allows bone regeneration thanks to its osteoinductive and osteoconductive properties. The purpose of this work is to describe the surgical-implant-prosthetic treatment of two complex cases using FFB. In particular, fresh frozen homologous bone grafts were used to correct the severe atrophy of the maxilla, and, then, once the graft integration was obtained, implant therapy was performed and implants placed in native bone were immediately loaded. PMID:23984108

  9. [Complex health service for treatment of patients with diabetic foot syndrome].

    PubMed

    Kosul'nikov, S O; Tarnopol'sky?, S O; Besedyn, A M; Karpenko, S I

    2014-11-01

    Complex service for treatment for patients, suffering diabetic foot syndrome, was created on the base of Dnipropetrovskiy Regional Clinical Hospital with the objective for application of high technologies. Creation of such a service have permitted to improve the results of the patients treatment. Enhancement of the performance rate of small operations on the foot have permitted to increase by 34.4% the quantity of patients, in whom a supportive function of the foot was preserved, and to reduce the conduction rate of the lower extremity amputation on a hip level, preserving a knee joint, by 39.5%, what is very important for the prosthesis. Widespread propaganda among population and primary link of the health service permit to reveal and eliminate complications of diabetes mellitus on earlier stages. PMID:25675744

  10. [The enzyme therapy within a complex treatment of hemophthalmos in patients with diabetes mellitus].

    PubMed

    Polunin, G S; Andzhelova, D V; Kiseleva, T N

    2004-01-01

    The efficiency of the enzyme therapy was studied in patients with hemophthalmos concurrent with diabetes mellitus of different types. Sixty-eight patients received parabulbar injections of the hemase and collelizin enzymes and another 25 patients underwent the routine therapy comprising injections of dicynone, emoxipin and heparinum. The method of ultrasound B-scanning was used to determine the area of hemorrhage spread into the vitreous body. A high efficiency of the enzyme therapy, as used within the complex treatment of hemophthalmos in patients with diabetes mellitus, was demonstrated. Ultrasound B-scanning is a highly informative technique in evaluating the enzyme-therapy efficiency. The enzyme therapy can be recommended as the most effective method for the treatment of hemophthalmos in patients with diabetes mellitus. PMID:15529531

  11. Ultrasound-responsive thrombus treatment with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator

    E-print Network

    Takada, Shoji

    is undertaken to design zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator (t In acute myocardial infarction, treatment strategies aimed at rapidly restoring complete and2 persistent deeply penetrate into the interior of body. Seve

  12. Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.

    PubMed

    Rodgers, Jean; Jones, Amy; Gibaud, Stéphane; Bradley, Barbara; McCabe, Christopher; Barrett, Michael P; Gettinby, George; Kennedy, Peter G E

    2011-09-01

    Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage T. b. rhodesiense infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-?-cyclodextrin and melarsoprol randomly-methylated-?-cyclodextrin. We found that these compounds retain trypanocidal properties in vitro and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy. PMID:21909447

  13. Minimization of round-off error and treatment of single phase and separated components in conventional and complex columns

    E-print Network

    Weisenfelder, Andrew J

    1961-01-01

    MINIMIZATION OF ROUND-OFF ERROR AND TREATMENT OF SINGLE PHASE AND SEPARATED COMPONENTS IN CONVENTIONAL AND COMPLEX COLUMNS A Thesis By Andrew Jacobs Weisenfelder Submitted to the Graduate School of the Agricultural and Mechanical College... of Texas in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 1961 MaJor SubJect: Chemical Engineering MINIMIZATION OF ROUND-OFF ERROR AND TREATMENT OF SINGLE PHASE AND SEPARATED COMPONENTS IN CONVENTIONAL AND COMPLEX...

  14. Stabilizing Group Treatment for Complex Posttraumatic Stress Disorder Related to Childhood Abuse Based on Psycho-Education and Cognitive Behavioral Therapy: A Pilot Study

    ERIC Educational Resources Information Center

    Dorrepaal, Ethy; Thomaes, Kathleen; Smit, Johannes H.; van Balkom, Anton J. L. M.; van Dyck, Richard; Veltman, Dick J.; Draijer, Nel

    2010-01-01

    Objective: This study tests a Stabilizing Group Treatment protocol, designed for the management of the long-term sequelae of child abuse, that is, Complex Posttraumatic Stress Disorder (Complex PTSD). Evidence-based treatment for this subgroup of PTSD patients is largely lacking. This stabilizing treatment aims at improving Complex PTSD using…

  15. Evidence-based treatment for adult women with child abuse-related Complex PTSD: a quantitative review

    PubMed Central

    Dorrepaal, Ethy; Thomaes, Kathleen; Hoogendoorn, Adriaan W.; Veltman, Dick J.; Draijer, Nel; van Balkom, Anton J. L. M.

    2014-01-01

    Introduction Effective first-line treatments for posttraumatic stress disorder (PTSD) are well established, but their generalizability to child abuse (CA)-related Complex PTSD is largely unknown. Method A quantitative review of the literature was performed, identifying seven studies, with treatments specifically targeting CA-related PTSD or Complex PTSD, which were meta-analyzed, including variables such as effect size, drop-out, recovery, and improvement rates. Results Only six studies with one or more cognitive behavior therapy (CBT) treatment conditions and one with a present centered therapy condition could be meta-analyzed. Results indicate that CA-related PTSD patients profit with large effect sizes and modest recovery and improvement rates. Treatments which include exposure showed greater effect sizes especially in completers’ analyses, although no differential results were found in recovery and improvement rates. However, results in the subgroup of CA-related Complex PTSD studies were least favorable. Within the Complex PTSD subgroup, no superior effect size was found for exposure, and affect management resulted in more favorable recovery and improvement rates and less drop-out, as compared to exposure, especially in intention-to-treat analyses. Conclusion Limited evidence suggests that predominantly CBT treatments are effective, but do not suffice to achieve satisfactory end states, especially in Complex PTSD populations. Moreover, we propose that future research should focus on direct comparisons between types of treatment for Complex PTSD patients, thereby increasing generalizability of results. PMID:25563302

  16. THE JOURNAL OF CHEMICAL PHYSICS 135, 094304 (2011) "Adiabatic-hindered-rotor" treatment of the parahydrogen-water complex

    E-print Network

    Le Roy, Robert J.

    2011-01-01

    THE JOURNAL OF CHEMICAL PHYSICS 135, 094304 (2011) "Adiabatic-hindered-rotor" treatment of the parahydrogen-water complex Tao Zeng,1 Hui Li,2 Robert J. Le Roy,1 and Pierre-Nicholas Roy1,a) 1 Department 1 September 2011) Inspired by a recent successful adiabatic-hindered-rotor treatment

  17. Successful treatment of complex cholangiolithiasis following orthotopic liver transplantation with interventional radiology

    PubMed Central

    Zhou, Chuan-Guo; Wei, Bao-Jie; Gao, Kun; Dai, Ding-Ke; Zhai, Ren-You

    2015-01-01

    Bile duct stones are a serious and the third most common complication of the biliary system that can occur following liver transplantation. The incidence rate of bile duct stones after liver transplantation is 1.8%-18%. The management of biliary stones is usually performed with endoscopic techniques; however, the technique may prove to be challenging in the treatment of the intrahepatic bile duct stones. We herein report a case of a 40-year-old man with rare, complex bile duct stones that were successfully eliminated with percutaneous interventional techniques. The complex bile duct stones were defined as a large number of bile stones filling the intra- and extrahepatic bile tracts, resulting in a cast formation within the biliary tree. Common complications such as hemobilia and acute pancreatitis were not present during the perioperative period. The follow-up period was 20 mo long. During the postoperative period, the patient maintained normal temperature, and normal total bilirubin and direct bilirubin levels. The patient is now living a high quality life. This case report highlights the safety and efficacy of the percutaneous interventional approach in the removal of complex bile duct stones following liver transplantation. PMID:25684970

  18. Pipeline™ embolization device for the treatment of complex intracranial aneurysms: a NICE Medical Technology Guidance.

    PubMed

    Withers, Kathleen; Carolan-Rees, Grace; Dale, Megan

    2013-02-01

    As part of its Medical Technologies Evaluation Programme, the National Institute of Health and Clinical Excellence (NICE) invited the manufacturer, Covidien, to provide clinical and economic evidence for the evaluation of the Pipeline™ embolization device (PED) for the treatment of complex intracranial aneurysms. Cedar; a consortium between Cardiff and Vale University Health Board and Cardiff University, was commissioned to act as an External Assessment Centre (EAC) for NICE to independently critique the manufacturers' submissions. This article gives an overview of the evidence provided, the findings of the EAC and the final guidance published by NICE. The scope issued by NICE considered PED as the intervention in a patient population with complex unruptured intracranial aneurysms (IAs), specifically large/giant, wide-necked and fusiform aneurysms. The comparator treatments identified were stent-assisted coiling, parent vessel occlusion, neurosurgical techniques and conservative management. The manufacturer claimed that PED fulfils a currently unmet clinical need in the treatment of large or giant, wide-necked or fusiform IAs. Thirteen studies were identified by the manufacturer as being relevant to the decision problem, with two of these included for data extraction. The EAC identified 16 studies as relevant, three of which had been published after the manufacturer's search. Data extraction was carried out on these studies as, although many were low level research comprising of case reports and case series, they provided useful, pertinent safety and outcome data. No relevant economic studies of the device were identified; therefore, a new economic model was designed by the manufacturer. The base-case scenario provided recognized the costs of PED to be higher than the costs for endovascular parent vessel occlusion, neurosurgical parent vessel occlusion, neurosurgical clipping and conservative management. However, PED was found to be cost saving compared with stent-assisted coiling, with a saving of Ł13,110 per patient. Analysis of the clinical data suggested that treatment with PED has high rates of clinical success with high rates of aneurysm occlusion and acceptable adverse events for the patient population. Economic evidence suggested that the costs in the base-case for PED may have been underestimated, meaning that PED would only become cost saving in patients who would otherwise require treatment with 32 coils or more. NICE Medical Technologies Guidance MTG10, issued in May 2012, recommends the adoption of PED in selected patients within the UK National Health Service (NHS). PMID:23341264

  19. [Potentials for the conservative therapy in the complex treatment of varicocele in adolescents].

    PubMed

    Popov, I S; Ne?mark, A I; Gazamatov, A V

    2013-01-01

    The article presents the results of the evaluation of the influence of varicocele on the reproductive system of adolescents from the perspective of involvement of periprostatic venous plexus and prostatovesicular complex in the pathological process. The study involved 90 adolescents 16-18 years old with left varicocele and disturbances in ejaculate parameters, of which 60 had pelvic congestion. Patients and control group received a comprehensive treatment, including preoperative trophic and flebotonic therapy, laparoscopic surgical clipping of the internal spermatic vein and post-operative rehabilitation. Patients of the study group along with this treatment received prostatotropic drug Vitaprost. According to the results of study, it was found that in patients with varicocele, attention should pay to the status of the venous outflow from the pelvic organs, which leads to the pelvic congestion and causes degenerative changes in the prostate in half of cases, which in turn negatively affects the spermogram parameters and increases the risk of subfertility. The use of prostatotropic drugs in the treatment of patients suffering from varicoceles with pelvic congestion is appropriate and pathogenetically justified, as it promotes a more rapid restoration of the structure and function of the prostate. PMID:24159772

  20. Bee Venom Pharmacopuncture: An Effective Treatment for Complex Regional Pain Syndrome

    PubMed Central

    Kim, Jong-Min; Jeon, Hyung-Joon; Kim, Hyun-Ji; Cho, Chong-Kwan; Yoo, Hwa-Seung

    2014-01-01

    Objectives: Treating complex regional pain syndrome (CRPS) is difficult because it still does not have a recommended therapy. A 29-year-old man was diagnosed with CRPS after surgery on his 4th and 5th left toes 7 years ago. Though he had undergone diverse pain treatment, the symptoms persisted, so he visited Dunsan Korean Medicine Hospital of Daejeon University. This case report presents results on the effect of bee venom pharmacopuncture in treating patient with CRPS. Methods: Bee venom pharmacopuncture (BVP), 0.15 to 0.4 mL dosage, was administered at GB43. The treatment was applied each week for a total 14 times. The symptoms were evaluated using a numeric rating scale (NRS) and the dosage of pain medicine. Results: On the first visit, he was taking an anticonvulsant, a trycyclic antidepressant, and an analgesic. On the NRS the worst pain in the toes received a score of 8. He also complained of severe pain and hypersensitivity when the 4th and the 5th toes were touched just slightly. Other complaint included dyspepsia, rash, and depression. After treatment, on the NRS, the score for toe pain was 0, and he no longer needed to take pain medication. During the 4-months follow-up period, he has remained without pain; neither have additional symptoms appeared nor adverse events occurred. Conclusion: BVP may have potential benefits for treating patients with CRPS. PMID:25780722

  1. Evaluating the Feasibility and Effects of the Complexity Account of Treatment Efficacy (CATE) for Joint Attention Intervention with Children with ASD

    E-print Network

    Becker, Stephanie D.

    2014-08-31

    , Robin, & Shapiro, 2002), and child phonology (Gierut, Morrisette, Hughes, & Rowland, 1996; alternatively Rvachew & Nowak, 2001). For adults with aphasia, Thompson et al. (1998) found that initiating treatment with more complex sentence structures... to compare treatment efficiency in four adults with agrammatic aphasia. Those patients receiving treatment on the most complex sentence structure (Object-relative constructions) generalized to the least complex structure in the complexity hierarchy (Wh...

  2. Treatment of complex infantile haemangioma in a resource-poor setting.

    PubMed

    Natawidjaja, Ronald; Wang, Ewen

    2014-01-01

    Infantile haemangiomas affect approximately 5% of the population and usually do not require treatment. However, complex cutaneous haemangiomas can cause disabling disfigurement, while haemangiomas in the brain, airway or gastrointestinal tract can cause life-threatening complications. Although children with infantile haemangiomas are often first brought to general practitioners and paediatricians by parents for care, they are thought of as a surgical problem and usually referred to specialty care. We present a case of an infant from a resource-poor setting in rural Indonesia with disfiguring facial haemangiomas, as well as a probable airway haemangioma causing stridor at rest. The infant was treated with oral propranolol with marked involution of the cutaneous haemangioma, resolution of stridor and increase in weight. PMID:25053694

  3. The use of TPA in combination with alcohol in the treatment of the recurrent complex hydrocele

    PubMed Central

    Metcalfe, Michael J.; Spouge, Rebecca J.; Spouge, David J.; Hoag, Chris C.

    2014-01-01

    A hydrocele is an abnormal collection of serous fluid in the space between the parietal and visceral layers of the tunica vaginalis. Hydrocele is the most common cause of painless scrotal swelling which affects about 1% of men. Generally, adult hydroceles are idiopathic in origin; however, inguinal surgery, varicocelectomy, infection, trauma and a patent processus vaginalis are each associated with the subsequent development of a hydrocele. Surgical removal of hydroceles is the gold standard of care. However, multiple cases have reported high success rates (ranging from 85% to 96%) using a combination of aspiration and sclerotherapy. We present a case of a patient with recurring complex hydrocele and effective treatment utilizing a combination of thrombolytic therapy, catheter drainage and subsequent alcohol ablation. PMID:25024803

  4. The use of TPA in combination with alcohol in the treatment of the recurrent complex hydrocele.

    PubMed

    Metcalfe, Michael J; Spouge, Rebecca J; Spouge, David J; Hoag, Chris C

    2014-05-01

    A hydrocele is an abnormal collection of serous fluid in the space between the parietal and visceral layers of the tunica vaginalis. Hydrocele is the most common cause of painless scrotal swelling which affects about 1% of men. Generally, adult hydroceles are idiopathic in origin; however, inguinal surgery, varicocelectomy, infection, trauma and a patent processus vaginalis are each associated with the subsequent development of a hydrocele. Surgical removal of hydroceles is the gold standard of care. However, multiple cases have reported high success rates (ranging from 85% to 96%) using a combination of aspiration and sclerotherapy. We present a case of a patient with recurring complex hydrocele and effective treatment utilizing a combination of thrombolytic therapy, catheter drainage and subsequent alcohol ablation. PMID:25024803

  5. Low-intensity laser radiation in complex treatment of inflammatory diseases of parodontium

    NASA Astrophysics Data System (ADS)

    Sokolova, Irina A.; Erina, Stanislava V.

    1995-04-01

    The problem of complex treatment of inflammatory disease of parodontium has become very acute and actual at the moment. The diseases of inflammatory nature are considered to be the most vital issues of the day. The state of the local immune system of oral cavity plays the most important role in the complicated mechanism of inflammatory process development in the tissues of parodontium. Recently physical factors have become predominant in the system of complex therapy of parodontitis. The application of low-intense laser radiation (LLR) is considered to be the most important and up-to-date method in the preventive dentistry. There were 60 patients of average damage rate suffering from chronic generalizing parodontitis at the age of 25 up to 55 under observation. The major goal of examination was to get the objective results of the following methods' application: parodontium index (Russel, 1956), hygiene index (Fyodorov, Volodkina, 1971), Bacterioscopy of dental-gingival pockets content, simple and broadened stomatoscopy (Kunin, 1970), SIgA level determination in mixed saliva (Manchini et all, 1965) and R-protein level in gingival blood (Kulberg, 1990). All the patients were split into 2 groups. The first group (30 patients) has undergone the laser therapy course while the second group of 30 patients couldn't get it (LLR). Despite the kind of therapy they have undergone, all the patients have got the local anti-inflammatory medicamental therapy. The results of clinical observations have proved the fact that laser therapy application makes it possible to shorten the course of treatment in 1.5 times. The shifts of oral cavity local resistance take place in case of chronic generalizing parodontitis. The direct immunostimulating effect could be observed as a result of LLR- therapy application. The close connection of both anti-inflammatory medicamental and LLR-therapy has proved the possibility of purposeful local immune status correction in case of parodontitis.

  6. Coupled variable selection for regression modeling of complex treatment patterns in a clinical cancer registry.

    PubMed

    Schmidtmann, I; Elsäßer, A; Weinmann, A; Binder, H

    2014-12-30

    For determining a manageable set of covariates potentially influential with respect to a time-to-event endpoint, Cox proportional hazards models can be combined with variable selection techniques, such as stepwise forward selection or backward elimination based on p-values, or regularized regression techniques such as component-wise boosting. Cox regression models have also been adapted for dealing with more complex event patterns, for example, for competing risks settings with separate, cause-specific hazard models for each event type, or for determining the prognostic effect pattern of a variable over different landmark times, with one conditional survival model for each landmark. Motivated by a clinical cancer registry application, where complex event patterns have to be dealt with and variable selection is needed at the same time, we propose a general approach for linking variable selection between several Cox models. Specifically, we combine score statistics for each covariate across models by Fisher's method as a basis for variable selection. This principle is implemented for a stepwise forward selection approach as well as for a regularized regression technique. In an application to data from hepatocellular carcinoma patients, the coupled stepwise approach is seen to facilitate joint interpretation of the different cause-specific Cox models. In conditional survival models at landmark times, which address updates of prediction as time progresses and both treatment and other potential explanatory variables may change, the coupled regularized regression approach identifies potentially important, stably selected covariates together with their effect time pattern, despite having only a small number of events. These results highlight the promise of the proposed approach for coupling variable selection between Cox models, which is particularly relevant for modeling for clinical cancer registries with their complex event patterns. PMID:25345575

  7. Anaerobic filter reactor performance for the treatment of complex dairy wastewater at industrial scale.

    PubMed

    Omil, Francisco; Garrido, Juan M; Arrojo, Belén; Méndez, Ramón

    2003-10-01

    The wastewaters discharged by raw milk quality control laboratories are more complex than the ones commonly generated by dairy factories because of the presence of certain chemicals such as sodium azide or chloramphenicol, which are used for preserving milk before analysis. The treatment of these effluents has been carried out in a full-scale plant comprising a 12 m(3) anaerobic filter (AF) reactor and a 28 m(3) sequential batch reactor (SBR). After more than 2 years of operation, a successful anaerobic treatment of these effluents was achieved, without fat removal prior to the anaerobic reactor. The organic loading rates maintained in the AF reactor were 5-6 kg COD/m(3) d, with COD removal being higher than 90%. No biomass washout was observed, and most of the fat contained in the wastewaters was successfully degraded. The addition of alkalinity is crucial for the maintenance of a proper buffer medium to ensure pH stability. The effluent of the AF reactor was successfully treated in the SBR reactor, and a final effluent with a COD content below 200 mg/l and total nitrogen below 10mg N/l was obtained. PMID:12946891

  8. 76 FR 49491 - Medicare Program; Section 3113: The Treatment of Certain Complex Diagnostic Laboratory Tests...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ...DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare...Complex Diagnostic Laboratory Tests Demonstration; Extension of...Complex Diagnostic Laboratory Tests Demonstration. The deadline...Complex Diagnostic Laboratory Tests Demonstration. The...

  9. Surgical treatment of complex aneurysms and thoracic aortic dissections with the Frozen Elephant Trunk technique

    PubMed Central

    Dias, Ricardo Ribeiro; Duncan, José Augusto; Vianna, Diego Sarty; de Faria, Leandro Batisti; Fernandes, Fábio; Ramirez, Félix José Álvares; Mady, Charles; Jatene, Fábio Biscegli

    2015-01-01

    Objective Report initial experience with the Frozen Elephant Trunk technique. Methods From July 2009 to October 2013, Frozen Elephant Trunk technique was performed in 21 patients (66% male, mean age 56 ±11 years). They had type A aortic dissection (acute 9.6%, chronic 57.3%), type B (14.3%, all chronic) and complex aneurysms (19%). It was 9.5% of reoperations and 38% of associated procedures (25.3% miocardial revascularization, 25.3% replacement of aortic valve and 49.4% aortic valved graft). Aortic remodeling was evaluated comparing preoperative and most recent computed tomography scans. One hundred per cent of complete follow-up, mean time of 28 months. Results In-hospital mortality of 14.2%, being 50% in acute type A aortic dissection, 8.3% in chronic type A aortic dissection, 33.3% in chronic type B aortic dissection and 0% in complex aneurysms. Mean times of cardiopulmonary bypass (152±24min), myocardial ischemia (115±31min) and selective cerebral perfusion (60±15min). Main complications were bleeding (14.2%), spinal cord injury (9.5%), stroke (4.7%), prolonged mechanical ventilation (4.7%) and acute renal failure (4.7%). The need for second-stage operation was 19%. False-lumen thrombosis was obtained in 80%. Conclusion Frozen Elephant Trunk is a feasible technique and should be considered. The severity of the underlying disease justifies high mortality rates. The learning curve is a reality. This approach allows treatment of more than two segments at once. Nonetheless, if a second stage is made necessary, it is facilitated.

  10. Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition

    PubMed Central

    Perna, Giampaolo; Daccň, Silvia; Menotti, Roberta; Caldirola, Daniela

    2011-01-01

    Background Although there are controversial issues (the “American view” and the “European view”) regarding the construct and definition of agoraphobia (AG), this syndrome is well recognized and it is a burden in the lives of millions of people worldwide. To better clarify the role of drug therapy in AG, the authors summarized and discussed recent evidence on pharmacological treatments, based on clinical trials available from 2000, with the aim of highlighting pharmacotherapies that may improve this complex syndrome. Methods A systematic review of the literature regarding the pharmacological treatment of AG was carried out using MEDLINE, EBSCO, and Cochrane databases, with keywords individuated by MeSH research. Only randomized, placebo-controlled studies or comparative clinical trials were included. Results After selection, 25 studies were included. All the selected studies included patients with AG associated with panic disorder. Effective compounds included selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, selective noradrenergic reuptake inhibitors, and benzodiazepines. Paroxetine, sertraline, citalopram, escitalopram, and clomipramine showed the most consistent results, while fluvoxamine, fluoxetine, and imipramine showed limited efficacy. Preliminary results suggested the potential efficacy of inositol; D-cycloserine showed mixed results for its ability to improve the outcome of exposure-based cognitive behavioral therapy. More studies with the latter compounds are needed before drawing definitive conclusions. Conclusion No studies have been specifically oriented toward evaluating the effect of drugs on AG; in the available studies, the improvement of AG might have been the consequence of the reduction of panic attacks. Before developing a “true” psychopharmacology of AG it is crucial to clarify its definition. There may be several potential mechanisms involved, including fear-learning processes, balance system dysfunction, high light sensitivity, and impaired visuospatial abilities, but further studies are warranted. PMID:22090798

  11. MA THELU -18/02/2010 J Medical Virology 1 IRES Complexity before IFN-alpha treatment and

    E-print Network

    Boyer, Edmond

    MA THELU - 18/02/2010 J Medical Virology 1 IRES Complexity before IFN-alpha treatment and Evolution in "Journal of Medical Virology 2007;79(3):242-53" DOI : 10.1002/jmv.20792 #12;MA THELU - 18/02/2010 J Medical Virology 2 INTRODUCTION Hepatitis C Virus (HCV) is one of the major causative agent of chronic hepatitis

  12. Impact of cosolvents on formation and properties of biopolymer nanoparticles formed by heat treatment of ?-lactoglobulin–Pectin complexes

    Microsoft Academic Search

    Wanlop Chanasattru; Owen Griffith Jones; Eric A. Decker; David Julian McClements

    2009-01-01

    The purpose of this study was to determine the influence of neutral cosolvents on the formation and properties of biopolymer nanoparticles formed by thermal treatment of protein–polysaccharide electrostatic complexes. Biopolymer particles were formed by heating (85 °C, 20 min) an aqueous solution containing a globular protein (?-lactoglobulin) and an anionic polysaccharide (beet pectin) above the thermal denaturation temperature (Tm) of the protein

  13. Cervical spinal cord stimulation treatment of deafferentation pain from brachial plexus avulsion injury complicated by complex regional pain syndrome.

    PubMed

    Chang Chien, George C; Candido, Kenneth D; Saeed, Kashif; Knezevic, Nebojsa Nick

    2014-08-01

    Brachial plexus avulsion is a rare and debilitating condition frequently associated with severe, intractable neuropathic pain. Interventional treatment modalities include dorsal root entry zone lesioning, stellate ganglion blockade, and neuromodulation such as spinal cord stimulation. We present a case of a 42-year-old woman with a traumatic left upper extremity brachial plexus avulsion injury after a motor vehicle accident and treatment of deafferentation pain complicated by complex regional pain syndrome type II. Previous unsuccessful interventions included repeated stellate ganglion blocks, transcutaneous electrical nerve stimulation, and opioid medication. After a successful trial of cervical spinal cord stimulator lead placement, she went on to an uneventful permanent implantation procedure. Spinal cord stimulation is an effective treatment for deafferentation pain and complex regional pain syndrome type II secondary to brachial plexopathy refractory to pharmacotherapy and conventional interventional attempts to modulate pain. PMID:25611136

  14. Computer-aided patch planning for treatment of complex coarctation of the aorta

    NASA Astrophysics Data System (ADS)

    Rietdorf, Urte; Riesenkampff, Eugénie; Kuehne, Titus; Huebler, Michael; Meinzer, Hans-Peter; Wolf, Ivo

    2009-02-01

    Between five and eight percent of all children born with congenitally malformed hearts suffer from coarctations of the aorta. Some severe coarctations can only be treated by surgical repair. Untreated, this defect can cause serious damage to organ development or even lead to death. Patch repair requires open surgery. It can affect patients of any age: newborns with severe coarctation and/or hypoplastic aortic arch as well as older patients with late diagnosis of coarctation of the aorta. Another patient group are patients of varying age with re-coarctation of the aorta or hypoplastic aortic arch after surgical and/or interventional repair. If anatomy is complex and interventional treatment by catheterization, balloon angioplasty or stent placement is not possible, surgery is indicated. The choice of type of surgery depends not only on the given anatomy but also on the experience the surgical team has with each method. One surgical approach is patch repair. A patch of a suitable shape and size is sewed into the aorta to expand the aortic lumen at the site of coarctation. At present, the shape and size of the patch are estimated intra-operatively by the surgeon. We have developed a software application that allows planning of the patch pre-operatively on the basis of magnetic resonance angiographic data. The application determines the diameter of the coarctation and/or hypoplastic segment and constructs a patch proposal by calculating the difference to the normal vessel diameter pre-operatively. Evaluation of MR angiographic datasets from 12 test patients with different kinds of aortic arch stenosis shows a divergence of only (1.5+/-1.2) mm in coarctation diameters between manual segmentations and our approach, with comparable time expenditure. Following this proposal the patch can be prepared and adapted to the patient's anatomy pre-operatively. Ideally, this leads to shorter operation times and a better long-term outcome with a reduced rate of residual stenosis and re-stenosis and aneurysm formation.

  15. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM

    PubMed Central

    Wang, Yonghua; Zheng, Chunli; Huang, Chao; Li, Yan; Chen, Xuetong; Wu, Ziyin; Wang, Zhenzhong; Xiao, Wei; Zhang, Boli

    2015-01-01

    Holistic medicine is an interdisciplinary field of study that integrates all types of biological information (protein, small molecules, tissues, organs, external environmental signals, etc.) to lead to predictive and actionable models for health care and disease treatment. Despite the global and integrative character of this discipline, a comprehensive picture of holistic medicine for the treatment of complex diseases is still lacking. In this study, we develop a novel systems pharmacology approach to dissect holistic medicine in treating cardiocerebrovascular diseases (CCDs) by TCM (traditional Chinese medicine). Firstly, by applying the TCM active ingredients screened out by a systems-ADME process, we explored and experimentalized the signed drug-target interactions for revealing the pharmacological actions of drugs at a molecule level. Then, at a/an tissue/organ level, the drug therapeutic mechanisms were further investigated by a target-organ location method. Finally, a translational integrating pathway approach was applied to extract the diseases-therapeutic modules for understanding the complex disease and its therapy at systems level. For the first time, the feature of the drug-target-pathway-organ-cooperations for treatment of multiple organ diseases in holistic medicine was revealed, facilitating the development of novel treatment paradigm for complex diseases in the future.

  16. Formulation, characterization and evaluation of cyclodextrin-complexed bendamustine-encapsulated PLGA nanospheres for sustained delivery in cancer treatment.

    PubMed

    Gidwani, Bina; Vyas, Amber

    2014-11-13

    Abstract PLGA nanospheres are considered to be promising drug carrier in the treatment of cancer. Inclusion complex of bendamustine (BM) with epichlorohydrin beta cyclodextrin polymer was prepared by freeze-drying method. Phase solubility study revealed formation of AL type complex with stability constant (Ks?=?645?M(-1)). This inclusion complex was encapsulated into PLGA nanospheres using solid-in-oil-in-water (S/O/W) technique. The particle size and zeta potential of PLGA nanospheres loaded with cyclodextrin-complexed BM were about 151.4?±?2.53?nm and?-?31.9?±?(-3.08)?mV. In-vitro release study represented biphasic release pattern with 20% burst effect and sustained slow release. DSC studies indicated that inclusion complex incorporated in PLGA nanospheres was not in a crystalline state but existed in an amorphous or molecular state. The cytotoxicity experiment was studied in Z-138 cells and IC50 value was found to be 4.3?±?0.11?µM. Cell viability studies revealed that the PLGA nanospheres loaded with complex exerts a more pronounced effect on the cancer cells as compared to the free drug. In conclusion, PLGA nanospheres loaded with inclusion complex of BM led to sustained drug delivery. The nanospheres were stable after 3 months of storage conditions with slight change in their particle size, zeta potential and entrapment efficiency. PMID:25391288

  17. Quality assurance for high dose rate brachytherapy treatment planning optimization: using a simple optimization to verify a complex optimization

    NASA Astrophysics Data System (ADS)

    Deufel, Christopher L.; Furutani, Keith M.

    2014-02-01

    As dose optimization for high dose rate brachytherapy becomes more complex, it becomes increasingly important to have a means of verifying that optimization results are reasonable. A method is presented for using a simple optimization as quality assurance for the more complex optimization algorithms typically found in commercial brachytherapy treatment planning systems. Quality assurance tests may be performed during commissioning, at regular intervals, and/or on a patient specific basis. A simple optimization method is provided that optimizes conformal target coverage using an exact, variance-based, algebraic approach. Metrics such as dose volume histogram, conformality index, and total reference air kerma agree closely between simple and complex optimizations for breast, cervix, prostate, and planar applicators. The simple optimization is shown to be a sensitive measure for identifying failures in a commercial treatment planning system that are possibly due to operator error or weaknesses in planning system optimization algorithms. Results from the simple optimization are surprisingly similar to the results from a more complex, commercial optimization for several clinical applications. This suggests that there are only modest gains to be made from making brachytherapy optimization more complex. The improvements expected from sophisticated linear optimizations, such as PARETO methods, will largely be in making systems more user friendly and efficient, rather than in finding dramatically better source strength distributions.

  18. Predicting stabilizing treatment outcomes for complex posttraumatic stress disorder and dissociative identity disorder: an expertise-based prognostic model.

    PubMed

    Baars, Erik W; van der Hart, Onno; Nijenhuis, Ellert R S; Chu, James A; Glas, Gerrit; Draijer, Nel

    2011-01-01

    The purpose of this study was to develop an expertise-based prognostic model for the treatment of complex posttraumatic stress disorder (PTSD) and dissociative identity disorder (DID). We developed a survey in 2 rounds: In the first round we surveyed 42 experienced therapists (22 DID and 20 complex PTSD therapists), and in the second round we surveyed a subset of 22 of the 42 therapists (13 DID and 9 complex PTSD therapists). First, we drew on therapists' knowledge of prognostic factors for stabilization-oriented treatment of complex PTSD and DID. Second, therapists prioritized a list of prognostic factors by estimating the size of each variable's prognostic effect; we clustered these factors according to content and named the clusters. Next, concept mapping methodology and statistical analyses (including principal components analyses) were used to transform individual judgments into weighted group judgments for clusters of items. A prognostic model, based on consensually determined estimates of effect sizes, of 8 clusters containing 51 factors for both complex PTSD and DID was formed. It includes the clusters lack of motivation, lack of healthy relationships, lack of healthy therapeutic relationships, lack of other internal and external resources, serious Axis I comorbidity, serious Axis II comorbidity, poor attachment, and self-destruction. In addition, a set of 5 DID-specific items was constructed. The model is supportive of the current phase-oriented treatment model, emphasizing the strengthening of the therapeutic relationship and the patient's resources in the initial stabilization phase. Further research is needed to test the model's statistical and clinical validity. PMID:21240739

  19. ENDOSCOPIC TREATMENT WITH DEXTRANOMER\\/HYALURONIC ACID FOR COMPLEX CASES OF VESICOURETERAL REFLUX

    Microsoft Academic Search

    MARCOS PEREZ-BRAYFIELD; ANDREW J. KIRSCH; TERRY W. HENSLE; MARTIN A. KOYLE; PETER FURNESS; HAL C. SCHERZ

    2004-01-01

    Purpose:The surgical correction of primary vesicoureteral reflux (VUR) is highly successful. This success decreases in more complex cases and often involves reoperation and increased morbidity. We present our experience with the use of subureteral injection of dextranomer\\/hyaluronic acid (Dx\\/HA) in complex cases of vesicoureteral reflux in which open surgery would have been indicated.

  20. Treatment of multiple residual complex coronary to right ventricular fistulae with covered stents following previous coil embolization

    PubMed Central

    Hamid, Tahir; Murphy, Gerard; Mahadevan, Vaikom S

    2012-01-01

    Congenital coronary artery fistulae may be isolated or may be associated with complex congenital cardiac abnormalities. In patients with complex congenital heart disease, multiple fistulous or sinusoidal communications with a cardiac chamber can occur. The treatment strategy includes surgery, coil embolization and covered stent deployment. The present article describes a case involving a 20-year-old patient with complex congenital heart lesions and multiple sinusoidal coronary to right ventricle fistulous communications, which remained patent despite coil embolization in childhood. Further coil or device embolization was deemed unlikely to be successful due to the presence of multiple communications; therefore, covered stents were deployed across the previously coiled segment of the coronary artery. The patient had an excellent clinical outcome on follow-up nine months later, with significant improvement of symptoms. PMID:23620706

  1. Strength and Formability Improvement of Al-Cu-Mn Aluminum Alloy Complex Parts by Thermomechanical Treatment with Sheet Hydroforming

    NASA Astrophysics Data System (ADS)

    Chen, Yi-Zhe; Liu, Wei; Yuan, Shi-Jian

    2015-05-01

    Normally, the strength and formability of aluminum alloys can be increased largely by severe plastic deformation and heat treatment. However, many plastic deformation processes are more suitable for making raw material, not for formed parts. In this article, an experimental study of the thermomechanical treatment by using the sheet hydroforming process was developed to improve both mechanical strength and formability for aluminum alloys in forming complex parts. The limiting drawing ratio, thickness, and strain distribution of complex parts formed by sheet hydroforming were investigated to study the formability and sheet-deformation behavior. Based on the optimal formed parts, the tensile strength, microhardness, grain structure, and strengthening precipitates were analyzed to identify the strengthening effect of thermomechanical treatment. The results show that in the solution state, the limiting drawing ratio of cylindrical parts could be increased for 10.9% compared with traditional deep drawing process. The peak values of tensile stress and microhardness of formed parts are 18.0% and 12.5% higher than that in T6 state. This investigation shows that the thermomechanical treatment by sheet hydroforming is a potential method for the products manufacturing of aluminum alloy with high strength and good formability.

  2. Typicality of Inanimate Category Exemplars in Aphasia Treatment: Further Evidence for Semantic Complexity

    ERIC Educational Resources Information Center

    Kiran, Swathi

    2008-01-01

    Purpose: The typicality treatment approach on improving naming was investigated within 2 inanimate categories ("furniture" and "clothing") using a single-subject experimental design across participants and behaviors in 5 patients with aphasia. Method: Participants received a semantic feature treatment to improve naming of either typical or…

  3. A New XRCC1-Containing Complex and Its Role in Cellular Survival of Methyl Methanesulfonate Treatment

    Microsoft Academic Search

    Hao Luo; Doug W. Chan; Tao Yang; Maria Rodriguez; Benjamin Ping-Chi Chen; Mei Leng; Jung-Jung Mu; David Chen; Zhou Songyang; Yi Wang; Jun Qin

    2004-01-01

    DNA single-strand break repair (SSBR) is important for maintaining genome stability and homeostasis. The current SSBR model derived from an in vitro-reconstituted reaction suggests that the SSBR complex mediated by X-ray repair cross-complementing protein 1 (XRCC1) is assembled sequentially at the site of damage. In this study, we provide biochemical data to demonstrate that two preformed XRCC1 protein complexes exist

  4. A new treatment for focal dystonias: incobotulinumtoxinA (Xeomin®), a botulinum neurotoxin type A free from complexing proteins

    PubMed Central

    Jimenez-Shahed, Joohi

    2012-01-01

    Dystonia is a movement disorder of uncertain pathogenesis that is characterized by involuntary and inappropriate muscle contractions which cause sustained abnormal postures and movements of multiple or single (focal) body regions. The most common focal dystonias are cervical dystonia (CD) and blepharospasm (BSP). The first-line recommended treatment for CD and BSP is injection with botulinum toxin (BoNT), of which two serotypes are available: BoNT type A (BoNT/A) and BoNT type B (BoNT/B). Conventional BoNT formulations include inactive complexing proteins, which may increase the risk for antigenicity, possibly leading to treatment failure. IncobotulinumtoxinA (Xeomin®; Merz Pharmaceuticals GmbH, Frankfurt, Germany) is a BoNT/A agent that has been recently Food and Drug Administration-approved for the treatment of adults with CD and adults with BSP previously treated with onabotulinumtoxinA (Botox®; Allergen, Inc, Irvine, CA) – a conventional BoNT/A. IncobotulinumtoxinA is the only BoNT product that is free of complexing proteins. The necessity of complexing proteins for the effectiveness of botulinum toxin treatment has been challenged by preclinical and clinical studies with incobotulinumtoxinA. These studies have also suggested that incobotulinumtoxinA is associated with a lower risk for stimulating antibody formation than onabotulinumtoxinA. In phase 3 noninferiority trials, incobotulinumtoxinA demonstrated significant improvements in CD and BSP symptoms in both primary and secondary measures, compared with baseline, and met criteria for noninferiority versus onabotulinumtoxinA. In placebo-controlled trials, incobotulinumtoxinA also significantly improved the symptoms of CD and BSP, with robust outcomes in both primary and secondary measures. The use of incobotulinumtoxinA has been well tolerated in all trials, with an adverse event profile similar to that of onabotulinumtoxinA. Based on these data, incobotulinumtoxinA is a safe and effective BoNT/A for the treatment of CD and BSP, and may pose a lower risk for immunogenicity leading to treatment failure compared with other available BoNT agents. This paper reviews the treatment of focal dystonias with BoNTs, in particular, incobotulinumtoxinA. Controlled trials from the existing incobotulinumtoxinA literature are summarized. PMID:22275842

  5. Looped Penrose Drain for Minimally Invasive Treatment of Complex Superficial Abscesses of the Hand

    PubMed Central

    Ugrinich, Marija; Chang, Benjamin

    2009-01-01

    Complex superficial abscesses are a common occurrence that traditionally have been treated by making relatively large incisions over the surface of the abscess, in order to ensure drainage and access for packing and dressing changes. The authors outline a minimally invasive technique that can be used for draining complex subcutaneous abscesses that extend over a large surface area. It is a simple technique utilizing multiple small incisions and looped penrose drains. This technique has been found to be very effective in many areas of the body and has multiple advantages over traditional incision, drainage, gauze packing, and dressing changes. PMID:19921343

  6. Treatment

    Cancer.gov

    The development of more effective and less toxic treatments is fundamental to improving outcomes for patients with cancer. NCI is leading efforts on several fronts to develop and evaluate new cancer treatments.

  7. Symposium for dental treatment of medically complex children: Practice based culminating experience a continuing education course

    Microsoft Academic Search

    Ayman Bizra

    2010-01-01

    The purpose of this Continuing Education Course is to provide oral health professionals with information to address the unique dental needs of medically complex children. The objective is to train dentists to treat special needs patients so these children have more access to oral healthcare. ^ Under the auspice of Dell Children Hospital of Austin, Lisa Jacob DDS MS is

  8. The Prescribed Pediatric Center: A Medical Day Treatment Program for Children with Complex Medical Conditions.

    ERIC Educational Resources Information Center

    Ruppert, Elizabeth S.; Karst, Thomas O.; Brogan, Mark G.

    1998-01-01

    The Prescribed Pediatric Center (Toledo, Ohio) is a community-based, multidisciplinary program for infants and children with chronic, complex medical conditions. This article describes program beginnings; the planning process; and the program's growth, development, and components. Initial program evaluation indicates positive effects on some…

  9. Complex I Disorders: Causes, Mechanisms, and Development of Treatment Strategies at the Cellular Level

    ERIC Educational Resources Information Center

    Valsecchi, Federica; Koopman, Werner J. H.; Manjeri, Ganesh R.; Rodenburg, Richard J.; Smeitink, Jan A. M.; Willems, Peter H. G. M.

    2010-01-01

    Mitochondrial oxidative phosphorylation (OXPHOS) represents the final step in the conversion of nutrients into cellular energy. Genetic defects in the OXPHOS system have an incidence between 1:5,000 and 1:10,000 live births. Inherited isolated deficiency of the first complex (CI) of this system, a multisubunit assembly of 45 different proteins,…

  10. The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance

    PubMed Central

    Baskar, Rajamanickam; Yap, Swee Peng; Chua, Kevin Lee Min; Itahana, Koji

    2012-01-01

    Cancer is a genetic disease, grows exponentially with the development of intrinsic and acquired treatment resistance. Past decade has witnessed a considerable progress towards the treatment and understanding of proposed hallmarks of cancer and together with advances in early detection and various treatment modalities. Radiation therapy is an integral part of cancer treatment armamentarium. In developed countries more than half of all cancer patients receive radiation therapy during their course of illness. Although radiation damages both cancer and normal cells, the goal of radiation therapy is to maximize the radiation dose to abnormal cancer cells while minimizing exposure to normal cells, which is adjacent to cancer cells or in the path of radiation. In recent years, life expectancy increases among cancer patients and this increase is due to the results of early diagnosis, screening efforts, improved treatments and with less late effects mostly secondary cancer development. Therefore, cancer survivorship issues have been gaining prominence in the area of radiation oncology research. Understanding the tradeoff between the expected decreases in normal tissue toxicity resulting from an improved radiation dose distribution to the targeted site is an increasingly pertinent, yet needed attention and research in the area of radiation oncology. In recent years, a number of potential molecular targets that involve either with radiation increased tumor cell killing or protecting normal cells have been identified. For clinical benefits, translating these findings to maximize the toxicity of radiation on tumor cells while safeguarding early or late normal cell toxicities using molecular targeted radioprotectors will be useful in radiation treatment. PMID:22860229

  11. The complexity of ADHD: diagnosis and treatment of the adult patient with comorbidities.

    PubMed

    Newcorn, Jeffrey H; Weiss, Margaret; Stein, Mark A

    2007-08-01

    Attention-deficit/hyperactivity disorder (ADHD) is an impairing but usually treatable condition. Popular culture propagates the myth that ADHD recedes with age; this is not the case. Although it is common, <20% of adults with ADHD are diagnosed or treated. Adults with ADHD show significant comorbidities with depressive disorders, anxiety disorders, substance use, oppositional defiant disorder, personality disorders, sleep problems, and learning disabilities. However, symptoms that result from ADHD, such as mood symptoms or lability, are often mistaken for comorbid disorders. Comorbidity with ADHD impacts treatment compliance, treatment response, and patient insight. Insufficient data on the interaction between ADHD and comorbidities impedes proper diagnosis and treatment. Better clinical tools for assessing these conditions are needed. Food and Drug Administration-approved pharmacologic treatments for adult ADHD include stimulants, dexmethylphenidate, and the nonstimulant atomoxetine. Effect sizes of approved medicines at approved doses are half those seen in children. Adults may also need longer duration of medication effects than children. Short-acting stimulants are likely to result in poorer adherence and have a higher risk for diversion or abuse. Risk of abuse is a major concern; stimulant treatments are controlled substances, and children with ADHD show increased risk of substance abuse. Psychosocial interventions may be beneficial in treating both ADHD and comorbidities.In this expert roundtable supplement, Margaret Weiss, MD, PhD, presents a comprehensive overview of complications surrounding differential diagnosis in adults with ADHD. Next, Mark A. Stein, PhD, reviews evaluation, comorbidity, and development of a treatment plan in this population. Finally, Jeffrey H. Newcorn, MD, provides a discussion on the pharmacologic options available for adults with ADHD, considering dosages specific to adults and common comorbidities. PMID:17667893

  12. The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance.

    PubMed

    Baskar, Rajamanickam; Yap, Swee Peng; Chua, Kevin Lee Min; Itahana, Koji

    2012-01-01

    Cancer is a genetic disease, grows exponentially with the development of intrinsic and acquired treatment resistance. Past decade has witnessed a considerable progress towards the treatment and understanding of proposed hallmarks of cancer and together with advances in early detection and various treatment modalities. Radiation therapy is an integral part of cancer treatment armamentarium. In developed countries more than half of all cancer patients receive radiation therapy during their course of illness. Although radiation damages both cancer and normal cells, the goal of radiation therapy is to maximize the radiation dose to abnormal cancer cells while minimizing exposure to normal cells, which is adjacent to cancer cells or in the path of radiation. In recent years, life expectancy increases among cancer patients and this increase is due to the results of early diagnosis, screening efforts, improved treatments and with less late effects mostly secondary cancer development. Therefore, cancer survivorship issues have been gaining prominence in the area of radiation oncology research. Understanding the tradeoff between the expected decreases in normal tissue toxicity resulting from an improved radiation dose distribution to the targeted site is an increasingly pertinent, yet needed attention and research in the area of radiation oncology. In recent years, a number of potential molecular targets that involve either with radiation increased tumor cell killing or protecting normal cells have been identified. For clinical benefits, translating these findings to maximize the toxicity of radiation on tumor cells while safeguarding early or late normal cell toxicities using molecular targeted radioprotectors will be useful in radiation treatment. PMID:22860229

  13. [Effectiveness of transcranial magnetic therapy in the complex treatment of alcohol abstinent syndrome].

    PubMed

    Staroverov, A T; Zhukov, O B; Ra?gorodski?, Iu M

    2008-01-01

    Fifty-four abstinent alcohol-dependent patients have been studied. Twenty-nine patients (a main group) received, along with basic therapy, a physiotherapeutic treatment (transcranial dynamic magnetic therapy) and 25 patients (a control group) received only basic therapy. The comparison of the efficacy of treatment in patients of the main and control groups revealed the benefits of transcranial dynamic magnetic therapy in CNS function, performance on memory and attention tests, state of autonomic nervous system and psychoemotional state of patients (the reduction of anxiety and depression). PMID:18833174

  14. Efficacy of second line antiepileptic drugs in the treatment of patients with medically refractive complex partial seizures.

    PubMed

    Dasheiff, R M; McNamara, D; Dickinson, L

    1986-01-01

    The efficacy of second-line antiepileptic drugs (AEDs) was evaluated in the treatment of 66 patients with complex partial seizures who had previously failed first-line AEDs. Methsuximide, valproate, or clorazepate had eliminated seizures in 11% of the patients at the end of the study. However, these good results deteriorated on longer follow-up and were not expected to be permanent. It is recommended that suitable patients with partial epilepsy be referred for surgical evaluation after failing the first-line AEDs, and that second-line AEDs be reserved for nonsurgical candidates. PMID:3082621

  15. Treatment of complex dissociative disorders: a comparison of interventions reported by community therapists versus those recommended by experts.

    PubMed

    Myrick, Amie C; Chasson, Gregory S; Lanius, Ruth A; Leventhal, Barry; Brand, Bethany L

    2015-01-01

    There is a paucity of empirical data to assist clinicians in choosing interventions to use with patients with complex dissociative disorder (DD; i.e., dissociative identity disorder and dissociative disorder not otherwise specified) at different stages in treatment. This study compared interventions used by a sample of international outpatient therapists treating DD clients in the 1st 2 stages of treatment with those recommended by expert DD therapists. There were many similarities between therapists' and experts' interventions, including the use of several emotion regulation and dissociation-focused interventions. However, community therapists reported significantly less focus on relationally oriented interventions, teaching and using grounding and containment skills, and stabilizing patients after revictimization by alleged perpetrators. This study has important implications for the development and implementation of training opportunities for DD therapists. PMID:25365637

  16. Semantic complexity in treatment of naming deficits in aphasia: Evidence from well-defined categories

    PubMed Central

    Kiran, Swathi; Johnson, Lauren

    2009-01-01

    Purpose Our previous work on manipulating typicality of category exemplars during treatment of naming deficits has shown that training atypical examples generalizes to untrained typical examples but not vice versa. In contrast to natural categories that consist of fuzzy boundaries, well-defined categories (e.g., shapes) have rigid category boundaries. Whether these categories illustrate typicality effects similar to natural categories is under debate. The present study addressed this question in the context of treatment for naming deficits in aphasia. Methods Using a single subject experiment design, three participants with aphasia received a semantic feature treatment to improve naming of either typical or atypical items of shapes, while generalization was tested to untrained items of the category. Results For two of the three participants, training naming of atypical examples of shapes resulted in improved naming of untrained typical examples. Training typical examples in one participant did not improve naming of atypical examples. All three participants, however, showed weak acquisition trends. Conclusions Results of the present study show equivocal support for manipulating typicality as a treatment variable within well defined categories. Instead, these results indicate that acquisition and generalization effects within well defined categories such as shapes are overshadowed by their inherent abstractness. PMID:18845698

  17. Copper complexing properties of dissolved organic matter: PARAFAC treatment of fluorescence quenching

    Microsoft Academic Search

    Stéphane Mounier; Huiyu Zhao; Cédric Garnier; Roland Redon

    Fluorescence quenching of the fluorescence is a useful method to determine copper complexing properties of the dissolved organic\\u000a matter. This technique provides express results often by choosing one or two excitation-emission fluorescence measurement\\u000a for a straight range of concentration. That why it is not representative of the whole sample. On another hand, using total\\u000a luminescence spectra gives lots of information

  18. Respirometric Evaluation of Strong Wastewater Activated Sludge Treatment for a Complex Chemical Industry

    Microsoft Academic Search

    E. Ubay Cokgor; G. Insel; E. Aydin; S. Ozdemir; D. Orhon

    \\u000a This study deals with respirometric modeling of biodegradation of complex organic matter generated from a chemical industry.\\u000a Evaluation with a multi-degradation model indicated that organic matter in raw wastewater has four types of biodegradable\\u000a components having different biodegradation characteristics. The model evaluation of batch respirogram indicated that the acclimated\\u000a biomass exhibited a delayed response after the addition of raw wastewater

  19. Density functional treatment of water-carbon dioxide van der Waals complex

    SciTech Connect

    Abashkin, Y.; Mele, F.; Russo, N.; Toscano, M. [Universita della Calabria, Arcavacata di Rende (Italy)

    1994-12-31

    LCGTO-LSD and LCGTO-NLSD methods have been tested for the study of water-carbon dioxide weakly bound binary complex. Different local and nonlocal exchange-correlation energy functionals and many grid radial points have been used. Results show that both nonlocal corrections and a large number of radial points in the grid are mandatory for well reproducing then experimental data. 19 refs., 1 fig., 2 tabs.

  20. TREATMENT OF ALCOHOLIC POLYNEUROPATHY WITH VITAMIN B COMPLEX: A RANDOMISED CONTROLLED TRIAL

    Microsoft Academic Search

    T. J. PETERS; J. KOTOWICZ; W. NYKA; W. KOZUBSKI; V. KUZNETSOV; F. VANDERBIST; S. DE NIET; D. MARCEREUIL; M. COFFINER

    2006-01-01

    Aims: To evaluate the therapeutic efficacy and safety of BEFACTForte 'new formulation' and BEFACTForte 'old formulation' in the treatment of sensory symptoms of alcoholic polyneuropathy. Methods: A multi-centre, randomised, double- blind, placebo-controlled study was conducted on 325 patients with sensory symptoms and signs of alcoholic polyneuropathy. Patients were randomised to the 'old formulation' (i.e. vitamins B1 ,B 2 ,B 6,

  1. Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment

    Microsoft Academic Search

    SA Holden; BA Teicher; K Boeheim; RR Weichselbaum; TJ Ervin

    1987-01-01

    The SCC-25 cell line is a well-established line derived from a human squamous carcinoma of the head and neck. The capacity of this cell line for recovery from potentially lethal damage following X-ray treatment has been documented. The survival curve of stationary phase SCC-25 cells exposed to various concentrations of bleomycin is biphasic with an initial sensitive phase and a

  2. Optimizing Treatment for Complex Cases of Childhood Obsessive Compulsive Disorder: A Preliminary Trial

    PubMed Central

    Peris, Tara S.; Piacentini, John

    2012-01-01

    Objective Family factors such as conflict, blame, and poor cohesion have been found to attenuate response to cognitive behavior therapy (CBT) for pediatric obsessive compulsive disorder (OCD). This study examined the feasibility and acceptability of a brief, personalized intervention for cases of pediatric OCD complicated by these family features. Method Twenty youth with a primary DSM-IV diagnosis of OCD (mean age = 12.50 years; 55% male; 60% Caucasian) and their families participated. To be included in the study, families were required to evidence poor functioning on measures of blame, conflict, and/or cohesion. Eligible families were randomly assigned to either standard treatment (ST) with 12 weeks of individual child CBT that included weekly parent check ins and psychoeducation or to Positive Family Interaction Therapy (PFIT), which consisted of 12 weeks of individual child CBT plus an additional six sessions of family treatment aimed at shifting family dynamics. Clinical outcomes were determined by blind independent evaluators using the Clinician's Global Impressions-Improvement (CGI-I) scale. Results All families completed the study. High levels of satisfaction were reported among participants in both arms of the study, despite the added burden of attending the PFIT sessions. Both mothers and fathers attended 95% of the PFIT family sessions. Families in the ST condition demonstrated a 40% response rate on the CGI-I; families in the PFIT condition demonstrated a 70% response rate. Treatment gains were maintained in both conditions at 3-month follow-up. Conclusions Preliminary data suggest that PFIT is acceptable and feasible. Further testing and treatment development are needed to optimize outcomes for complicated cases of pediatric OCD. PMID:22548378

  3. Metal complexes as photochemical nitric oxide precursors: potential applications in the treatment of tumors.

    PubMed

    Ostrowski, Alexis D; Ford, Peter C

    2009-12-28

    The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a gamma-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent. PMID:20023893

  4. Alternative Techniques for Treatment of Complex Below-the Knee Arterial Occlusions in Diabetic Patients With Critical Limb Ischemia

    SciTech Connect

    Gandini, Roberto [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy); Uccioli, Luigi [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy); Spinelli, Alessio; Del Giudice, Costantino, E-mail: costantino.delgiudice@yahoo.it; Ros, Valerio Da; Volpi, Tommaso [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy); Meloni, Marco [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Internal Medicine (Italy); Simonetti, Giovanni [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)] [IRCCS Policlinico di Tor Vergata, Department of Diagnostic Imaging, Interventional Radiology, Radiotherapy, and Nuclear Medicine (Italy)

    2013-02-15

    The purpose of this study was to describe alternative endovascular (EV) techniques and assess their feasibility and efficacy in minimizing failure rates in limb salvage for the treatment of complex below-the knee (BTK) occlusions that could not be crossed with a conventional antegrade access. Between December 2007 and November 2010, 1,035 patients (557 male) underwent EV treatment for critical limb ischemia in our institution. In 124 (12% [83 male], mean age 68.2 {+-} 0.5 years) patients, transfemoral antegrade revascularization attempt failed, and an alternative approach was used. Follow-up was performed at 1 and 6 months. Results were compared with 56 patients treated between November 2002 and November 2007, in whom conventional technique was unsuccessful and unconventional techniques were not adopted. Technical success was achieved in 119 (96%) patients. The limb-salvage rates were 96.8% and 83% at 1- and 6-month follow-up, respectively. Sixteen (12.9%) and 33 (26.6%) patients underwent reintervention at 1- and 6-month follow-up, respectively. Transcutaneous oxygen tension increased at 1 month (44.7 {+-} 1.1 vs. 15.7 {+-} 0.8 mmHg; p < 0.001) and remained stable at follow-up. Twenty (16.1%) patients required major amputation. Thirteen (10.4%) patients died during follow-up. In our previous experience, percutaneous transluminal angioplasty failure, amputation, and death rates were 10.9, 39.2, and 23.2%, respectively. Alternative techniques allowed a significant decrease of major amputation and death rates (p = 0.0001 and p = 0.02, respectively). The use of alternative techniques seems feasible in case of a failed antegrade BTK revascularization attempt and could minimize failure rates in the treatment of complex occlusions while providing satisfying clinical success rates at 6 months.

  5. Direct access to the middle meningeal artery for embolization of complex dural arteriovenous fistula: a hybrid treatment approach.

    PubMed

    Lin, Ning; Brouillard, Adam M; Mokin, Maxim; Natarajan, Sabareesh K; Snyder, Kenneth V; Levy, Elad I; Siddiqui, Adnan H

    2014-01-01

    Endovascular embolization has become increasingly favored over microsurgical resection for treatment of complex dural arteriovenous fistulas (DAVFs). However, endovascular treatment can be restricted by tortuous transarterial access and a transvenous approach is not always feasible. We present a Borden III DAVF treated by direct access to the middle meningeal artery (MMA) and Onyx embolization performed in a hybrid operating room-angiography suite. A middle-aged patient with pulsatile headaches was found to have left transverse sinus occlusion and DAVF with retrograde cortical venous drainage fed by multiple external carotid artery (ECA) feeders. Endovascular attempts via conventional transvenous and transarterial routes were unsuccessful, and the major MMA feeder was accessed directly after temporal craniotomy was performed under neuronavigation. Onyx embolization was performed; complete occlusion of the fistula was achieved. Three-month follow-up angiography showed no residual filling; the patient remains complication-free. A combined surgical-endovascular technique in a hybrid operating room-angiography suite can be an effective treatment for DAVFs complicated by inaccessible arterial and transvenous approaches. PMID:24903968

  6. Direct access to the middle meningeal artery for embolization of complex dural arteriovenous fistula: a hybrid treatment approach.

    PubMed

    Lin, Ning; Brouillard, Adam M; Mokin, Maxim; Natarajan, Sabareesh K; Snyder, Kenneth V; Levy, Elad I; Siddiqui, Adnan H

    2015-07-01

    Endovascular embolization has become increasingly favored over microsurgical resection for treatment of complex dural arteriovenous fistulas (DAVFs). However, endovascular treatment can be restricted by tortuous transarterial access and a transvenous approach is not always feasible. We present a Borden III DAVF treated by direct access to the middle meningeal artery (MMA) and Onyx embolization performed in a hybrid operating room-angiography suite. A middle-aged patient with pulsatile headaches was found to have left transverse sinus occlusion and DAVF with retrograde cortical venous drainage fed by multiple external carotid artery (ECA) feeders. Endovascular attempts via conventional transvenous and transarterial routes were unsuccessful, and the major MMA feeder was accessed directly after temporal craniotomy was performed under neuronavigation. Onyx embolization was performed; complete occlusion of the fistula was achieved. Three-month follow-up angiography showed no residual filling; the patient remains complication-free. A combined surgical-endovascular technique in a hybrid operating room-angiography suite can be an effective treatment for DAVFs complicated by inaccessible arterial and transvenous approaches. PMID:24916414

  7. Psychophysiological predictors of working alliance among treatment-seeking women with complex trauma exposure.

    PubMed

    Doukas, Ashley; D'Andrea, Wendy; Doran, Jennifer; Pole, Nnamdi

    2014-12-01

    Research has established that trauma-related symptoms may impede the formation of a strong working alliance (i.e., interpersonal connection, trust, and shared goals between therapist and client). As the alliance is critical in trauma-focused therapy, we studied how clients' pretherapy factors, including symptoms and psychophysiological arousal, predict treatment alliance. We examined symptoms and physiological responses in 27 women who had exposure to extreme interpersonal violence; all of whom were enrolled in therapy. All had symptoms consistent with a diagnosis of posttraumatic stress disorder. Clients completed measures of working alliance and were assessed before and after treatment on measures of symptoms and autonomic arousal. Autonomic assessment included measures of skin conductance and respiratory sinus arrhythmia (RSA), taken during baseline, while viewing positive and then trauma-related slides, and during recovery. Higher alliance ratings were predicted by lower pretherapy skin conductance during trauma slides (r = -.41, p = .049) and recovery (r = -.44, p = .047) and higher RSA during baseline (r = .47, p = .027) and positive slides (r = .43, p = .044). Findings remained significant even after partialling pretherapy symptoms. These data on a high-need but understudied population suggest that sympathetic and parasympathetic arousal may help traumatized clients effectively engage in therapy, further supporting the role of parasympathetic activity in social engagement. PMID:25522730

  8. [Transcranial magnetic therapy in the complex treatment of affective disorders in patients with alcoholism].

    PubMed

    Staroverov, A T; Vil'ianov, V B; Ra?gorodski?, Iu M; Rogozina, M A

    2008-01-01

    A main group--32 patients receiving transcranial magnetic therapy (TMT) in addition to the basic treatment (nootrops, hepatoprotectors, vitamins/minerals etc)--was compared to a control group (30 patients) receiving placebo instead of TMT. All patients, aged from 35 to 64 years, had the second stage of alcoholism with illness duration from 4 to 12 years and were in the postabstinent state at the moment of treatment. The TMT course included 10 daily sessions with a 10-20 min exposure. A somatic, neurological and instrumental study, including cardiointervalography, electroencephalography, assessment of autonomic system state and psychometric scales for depression and anxiety, was conducted before, during and after the therapy. The improvement of health, mood and sleep, increase of tolerability to physical loading and reduction of alcohol craving were observed after TMT in 75% of patients in the main group and in 30% in the control one. The improvement of patient's state was correlated with the data of the paraclinical study (electrophysiological parameters of the autonomic nervous system and psychometric scales scores). PMID:18454095

  9. Complex PTSD: research directions for nosology/assessment, treatment, and public health

    PubMed Central

    Ford, Julian D.

    2015-01-01

    Complex posttraumatic stress disorder (CPTSD) in children and adolescents extends beyond the core PTSD symptoms to dysregulation in three psychobiological domains: (1) emotion processing, (2) self-organization (including bodily integrity), and (3) relational functioning. CPTSD research directions for the next decade and beyond are identified in three areas: (1) diagnostic classification (establishing the empirical integrity of CPTSD as a distinct form of psychopathology) and psychometric assessment [validation and refinement of measures of childhood polyvictimization and developmental trauma disorder (DTD)], (2) rigorous evaluation and refinement of interventions (and algorithms for their delivery) developed or adapted for CPTSD and DTD, and (3) the epidemiology of CPTSD and DTD, and their public health and safety impact, across the lifespan and intergenerationally, for populations, nations, and cultures. PMID:25994023

  10. New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.

    PubMed

    Liu, Joyce; Matulonis, Ursula A

    2014-10-15

    An improved understanding of the genomics of ovarian cancer and the separation of ovarian cancer into histologically and molecularly defined subgroups have affected drug development and clinical trial design in ovarian cancer. Active therapies that have been tested in ovarian cancer include agents that inhibit angiogenesis and poly (ADP-ribose) polymerase inhibitors (PARPi). However, no FDA drug approvals for ovarian cancer have been granted since 2006, and overall survival improvements have been difficult to achieve with new agents. The genomic complexity of ovarian cancer and modest single-agent activity of many biologic agents in this disease have led to testing of biologic agent combinations. In this article, we review recent advances in the understanding of the molecular diversity of ovarian cancer as well as emerging therapeutic strategies such as new agents and biologic combinations that attempt to target multiple aberrant pathways in this cancer. PMID:25320365

  11. Complex PTSD: research directions for nosology/assessment, treatment, and public health.

    PubMed

    Ford, Julian D

    2015-01-01

    Complex posttraumatic stress disorder (CPTSD) in children and adolescents extends beyond the core PTSD symptoms to dysregulation in three psychobiological domains: (1) emotion processing, (2) self-organization (including bodily integrity), and (3) relational functioning. CPTSD research directions for the next decade and beyond are identified in three areas: (1) diagnostic classification (establishing the empirical integrity of CPTSD as a distinct form of psychopathology) and psychometric assessment [validation and refinement of measures of childhood polyvictimization and developmental trauma disorder (DTD)], (2) rigorous evaluation and refinement of interventions (and algorithms for their delivery) developed or adapted for CPTSD and DTD, and (3) the epidemiology of CPTSD and DTD, and their public health and safety impact, across the lifespan and intergenerationally, for populations, nations, and cultures. PMID:25994023

  12. Multimodal treatment strategies for complex pediatric cerebral arteriovenous fistulas: contemporary case series at Barrow Neurological Institute.

    PubMed

    Zaidi, Hasan A; Kalani, M Yashar S; Spetzler, Robert F; McDougall, Cameron G; Albuquerque, Felipe C

    2015-06-01

    OBJECT Pediatric cerebral arteriovenous fistulas (AVFs) are rare but potentially lethal vascular lesions. Management strategies for these lesions have undergone considerable evolution in the last decade with the advent of new endovascular, surgical, and radiosurgical technologies. This study sought to review current treatment strategies and long-term clinical outcomes at a high-volume cerebrovascular institute. METHODS A retrospective chart review was performed on patients with a diagnosis of cerebral AVF from 1999 to 2012. Patients with carotid-cavernous fistulas, vein of Galen malformations, and age > 18 years were excluded from final analysis. Medical history, surgical and nonsurgical treatment, and clinical outcomes were documented. Pre- and postoperative angiograms were analyzed to assess for obliteration of the fistula. RESULTS Seventeen patients with pial AVFs (29.4%), dural AVFs (64.7%), or mixed pial/dural AVFs (5.9%) were identified. The majority of lesions were paramedian (70.6%) and supratentorial (76.5%). The study population had a mean age of 6.4 years, with a slight male predominance (52.9%), and the most common presenting symptoms were seizures (23.5%), headaches (17.6%), congestive heart failure (11.7%), and enlarging head circumference (11.7%). Among patients who underwent intervention (n = 16), 56.3% were treated with endovascular therapy alone, 6.3% were treated with open surgery alone, and 37.5% required a multimodal approach. Overall, 93.8% of the treated patients received endovascular treatment, 43.8% received open surgery, and 12.5% received radiosurgery. Endovascular embolysates included Onyx (n = 5), N-butyl cyanoacrylate (NBCA; n = 4), or coil embolization (n = 7) with or without balloon assistance (n = 2). Complete angiographic obliteration was achieved in 87.5% at the last follow-up evaluation (mean follow-up 3.1 years). One infant with incomplete AVF obliteration died of congestive heart failure, and 1 patient with complete obliteration died of acute sinus thrombosis, with an overall complication rate of 18.8%. CONCLUSIONS Pediatric cerebral AVFs are challenging neurosurgical lesions. Although advancements in endovascular therapy in the last decade have greatly changed the natural course of this disease, a multidisciplinary approach remains necessary for a large subset of patients. Surgeon experience with a thorough analysis of preoperative imaging is paramount to achieving acceptable clinical outcomes. PMID:25815632

  13. Transvenous treatment of complex cavernous dural arteriovenous fistulae with Onyx and coils.

    PubMed

    Li, Liang; Cui, Jin-Guo; Liang, Zhi-Hui; Xu, Shu-Bin; Li, Jia; Tian, Hui-Qin; Fan, Yu-Hong

    2011-01-01

    Transvenous embolization has become the treatment of choice for such lesions We evaluated Onxy for patients with cavernous dural arteriovenous fistulae (CDAVFs) who underwent transvenous embolization via different transvenous approaches. Case records of six patients with symptomatic CDAVFs, treated between October 2006 and November 2007 were reviewed. A total of seven transvenous procedures were performed in the six patients with CDAVFs. All the patients with CDAVFs of the cavernous sinus were symptom free following embolization. The approach via the internal jugular vein and the inferior petrosal sinus was possible in four of the six patients, with complete occlusion of the fistula. In the remaining two patients, the approach was via the facial vein. Transient bradyarrythmia without morbidity was the only complication in two patients. PMID:21339671

  14. A boundary collocation meshfree method for the treatment of Poisson problems with complex morphologies

    NASA Astrophysics Data System (ADS)

    Soghrati, Soheil; Mai, Weijie; Liang, Bowen; Buchheit, Rudolph G.

    2015-01-01

    A new meshfree method based on a discrete transformation of Green's basis functions is introduced to simulate Poisson problems with complex morphologies. The proposed Green's Discrete Transformation Method (GDTM) uses source points that are located along a virtual boundary outside the problem domain to construct the basis functions needed to approximate the field. The optimal number of Green's functions source points and their relative distances with respect to the problem boundaries are evaluated to obtain the best approximation of the partition of unity condition. A discrete transformation technique together with the boundary point collocation method is employed to evaluate the unknown coefficients of the solution series via satisfying the problem boundary conditions. A comprehensive convergence study is presented to investigate the accuracy and convergence rate of the GDTM. We will also demonstrate the application of this meshfree method for simulating the conductive heat transfer in a heterogeneous materials system and the dissolved aluminum ions concentration in the electrolyte solution formed near a passive corrosion pit.

  15. A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.

    PubMed

    Dasanu, Constantin A; Wiernik, Peter H; Vaillant, Juan; Alexandrescu, Doru T

    2007-01-01

    A 53-year-old black man was diagnosed with poorly differentiated adenocarcinoma of the lung and treated initially with 4 cycles of paclitaxel in combination with carboplatin and external-beam radiation therapy with a good clinicoradiologic response. The patient tolerated the chemotherapy well and did not develop any skin or nail changes during that period of time. His lung cancer recurred 10 months later, when he was found to have bone metastases. Second-line chemotherapy with pemetrexed 500 mg/m2 intravenously every 3 weeks was commenced. A week prior, the patient was started on folic acid 1 mg orally daily and given an injection of vitamin B12 1000 microg intramuscularly that was continued every 3 cycles thereafter. Dexamethasone 4 mg orally twice daily was given around the time of chemotherapy administration to prevent the dermatitis associated with the drug. The patient denied taking other drugs. Two months into his second-line chemotherapy, he developed multiple, concomitant, transverse and longitudinal black lines in all of his fingernails and toenails. After an interval of 3 months, he presented a complex pattern of nail hyperpigmentation, from combined dense horizontal and longitudinal streaks in some nails to diffuse black discoloration in others (Figure). Other associated changes included koilonychia, dystrophy, and friability of nail plates. Along with normal results of a hepatorenal panel and normal serum vitamin B12 and folate levels, no metabolic or endocrinologic alterations were present to explain the nail pigmentation and dystrophic changes. Results of his mycologic examination and cultures came back negative. When questioned, he denied taking any other drugs including other alternative medicine approaches or vitamin supplements, particularly retinoids, well known for causing severe nail dystrophy. PMID:17366681

  16. Midterm Results of a Combined Biological and Mechanical Approach for the Treatment of a Complex Knee Lesion

    PubMed Central

    Filardo, G.; Di Martino, A.; Delcogliano, M.; Marcacci, M.

    2012-01-01

    Objective: Complex fractures of the tibial plateau are difficult to treat and present a high complication rate. The goal of this report is to describe a combined biological and mechanical approach to restore all morphological and functional knee properties. Methods: We treated a 50-year-old woman, who was affected by a posttraumatic osteochondral lesion and depression of the lateral tibial plateau with knee valgus deviation. The mechanical axis was corrected with a lateral tibial plateau elevation osteotomy, the damaged joint surface was replaced by a recently developed biomimetic osteochondral scaffold, and a hinged dynamic external fixator was applied to protect the graft and at the same time to allow postoperative joint mobilization. Results: A marked clinical improvement was documented at 12 months and further improved up to 5 years, with pain-free full range of motion and return to previous activities. The MRI evaluation at 12 and 24 months showed that the implant remained in site with a hyaline-like signal and restoration of the articular surface. Conclusion: This case report describes a combined surgical approach for complex knee lesions that could represent a treatment option to avoid or at least delay posttraumatic osteoarthritis and more invasive procedures.

  17. Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation.

    PubMed

    Pua, Min Ley; Yoshitomi, Toru; Chonpathompikunlert, Pennapa; Hirayama, Aki; Nagasaki, Yukio

    2013-12-28

    Reactive oxygen species (ROS) scavengers have not been widely used for treatment of local inflammatory reactions such as arthritis and periodontal disease because they are rapidly eliminated from the inflamed site, which results in a low therapeutic effect. Therefore, to enhance the local retention time of ROS scavengers, we developed a redox-active injectable gel (RIG) system by using poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene]-b-poly(ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene] (PMNT-PEG-PMNT) triblock copolymer, which possesses ROS scavenging nitroxide radicals as side chains of the PMNT segment. Cationic PMNT segment in PMNT-PEG-PMNT forms polyion complexes with anionic poly(acrylic acid) (PAAc) to form a flower-like micelle (ca. 79 nm), which exhibits in situ thermo-irreversible gelation under physiological conditions. We confirmed the prolonged site-specific retention time of RIG by performing in vivo noninvasive electron spin resonance imaging and quantitative evaluation. In contrast to low-molecular-weight nitroxide radical compounds that disappeared from injection sites in less than 1h after subcutaneous injection, 40% of the RIG remained even at 3 days. We also found that RIG inhibits neutrophil infiltration and cytokine production, which leads to suppression of hyperalgesia. These findings indicate the potential of RIG as an innovative approach for treatment of local inflammation. PMID:24157475

  18. [Effectiveness of 3-hydroxypyridine and succinic acid derivatives in complex treatment of primary open-angle glaucoma].

    PubMed

    Volchegorski?, I A; Tur, E V; Soliannikova, O V; Rykun, V S; Sumina, M S; Dmitrienko, V N; Berdnikova, E V

    2012-01-01

    Prospective, placebo-controlled, single-blind, randomized clinical investigation of the influence of domestic 3-hydroxypyridine and succinic acid derivatives (emoxipin, reamberin, mexidol) on the effectiveness of a complex treatment of primary open-angle glaucoma (POAG) has been performed in a group of patients. It is established that intravenous infusion of 3-hydroxypyridine derivatives (emoxipin and mexidol) for two weeks, beginning 14 days after the start of POAG treatment, produced a retinoprotective action, with three months postponed changes in the central retinal artery (CRA) blood velocity. The retinoprotective effect of emoxipin (single dose, 150 mg) was manifested by reduction in the horizontal size of blind spot in two weeks, with the subsequent reduction of the CRA end-diastolic blood velocity observed three months after finish of the infusion therapy. The administration of mexidol (single dose, 300 mg) after 14 days of treatment led to widening of the summarized field of vision (test-object square, 16 mm), accompanied by a decrease in the electrosensitivity threshold of the optic nerve and the intensity of POAG-associated hypothymia. All indices of CRA blood velocity increased three months after termination of mexidol infusions. Reamberin (single dose, 400 ml 1,5% solution of reamberine, containing polyelectrolyte and meglumine succinate mixture) did not show retinoprotective action, but caused proatherogenic changes of blood lipids and 3 months postponed CRA end-diastolic blood velocity increase. The effect of mexidol (which is a derivative of both 3- hydroxypyridine and succinic acid) exceeds that of separate 3-hydroxypyridine (emoxipin) and succinic acid (reamberin) derivatives in the degree of retinoprotection and positive effect on the optic nerve condition and mood of POAG patients. PMID:23025048

  19. Bortezomib (PS-341) Treatment Decreases Inflammation and Partially Rescues the Expression of the Dystrophin-Glycoprotein Complex in GRMD Dogs

    PubMed Central

    Araujo, Karla P. C.; Bonuccelli, Gloria; Duarte, Caio N.; Gaiad, Thais P.; Moreira, Dayson F.; Feder, David; Belizario, José E.; Miglino, Maria A.; Lisanti, Michael P.; Ambrosio, Carlos E.

    2013-01-01

    Golden retriever muscular dystrophy (GRMD) is a genetic myopathy corresponding to Duchenne muscular dystrophy (DMD) in humans. Muscle atrophy is known to be associated with degradation of the dystrophin-glycoprotein complex (DGC) via the ubiquitin-proteasome pathway. In the present study, we investigated the effect of bortezomib treatment on the muscle fibers of GRMD dogs. Five GRMD dogs were examined; two were treated (TD- Treated dogs) with the proteasome inhibitor bortezomib, and three were control dogs (CD). Dogs were treated with bortezomib using the same treatment regimen used for multiple myeloma. Pharmacodynamics were evaluated by measuring the inhibition of 20S proteasome activity in whole blood after treatment and comparing it to that in CD. We performed immunohistochemical studies on muscle biopsy specimens to evaluate the rescue of dystrophin and dystrophin-associated proteins in the muscles of GRMD dogs treated with bortezomib. Skeletal tissue from TD had lower levels of connective tissue deposition and inflammatory cell infiltration than CD as determined by histology, collagen morphometry and ultrastructural analysis. The CD showed higher expression of phospho-NF?B and TGF-?1, suggesting a more pronounced activation of anti-apoptotic factors and inflammatory molecules and greater connective tissue deposition, respectively. Immunohistochemical analysis demonstrated that dystrophin was not present in the sarcoplasmic membrane of either group. However, bortezomib-TD showed higher expression of ?- and ?-dystroglycan, indicating an improved disease histopathology phenotype. Significant inhibition of 20S proteasome activity was observed 1 hour after bortezomib administration in the last cycle when the dose was higher. Proteasome inhibitors may thus improve the appearance of GRMD muscle fibers, lessen connective tissue deposition and reduce the infiltration of inflammatory cells. In addition, proteasome inhibitors may rescue some dystrophin-associated proteins in the muscle fiber membrane. PMID:23579193

  20. Thoracic sympathetic block for the treatment of complex regional pain syndrome type I: a double-blind randomized controlled study.

    PubMed

    de Oliveira Rocha, Roberto; Teixeira, Manoel Jacobsen; Yeng, Lin Tchia; Cantara, Mirlene Gardin; Faria, Viviane Gentil; Liggieri, Victor; Loduca, Adrianna; Müller, Barbara Maria; Souza, Andrea C M S; de Andrade, Daniel Ciampi

    2014-11-01

    Pain relief in complex regional pain syndrome (CRPS) remains a major challenge, in part due to the lack of evidence-based treatment trials specific for this condition. We performed a long-term randomized, double-blinded active-control study to evaluate the efficacy of thoracic sympathetic block (TSB) for upper limb type I CRPS. The study objective was to evaluate the analgesic effect of TSB in CRPS. Patients with CRPS type I were treated with standardized pharmacological and physical therapy and were randomized to either TSB or control procedure as an add-on treatment. Clinical data, pain intensity, and interference (Brief Pain Inventory), pain dimensions (McGill Pain Questionnaire [MPQ]), neuropathic characteristics (Neuropathic Pain Symptom Inventory [NPSI]), mood, upper limb function (Disabilities of Arm, Shoulder and Hand), and quality of life were assessed before, and at 1 month and 12 months after the procedure. Thirty-six patients (19 female, 44.7 ± 11.1 years of age) underwent the procedure (17 in the TSB group). Average pain intensity at 1 month was not significantly different after TSB (3.5 ± 3.2) compared to control procedure (4.8 ± 2.7; P=0.249). At 12 months, however, the average pain item was significantly lower in the TSB group (3.47 ± 3.5) compared to the control group (5.86 ± 2.9; P=0.046). Scores from the MPQ, evoked-pain symptoms subscores (NPSI), and depression scores (Hospital Anxiety and Depression Scale) were significantly lower in the TSB group compared to the control group at 1 and at 12 months. Other measurements were not influenced by the treatment. Quality of life was only slightly improved by TSB. No major adverse events occurred. Larger, multicentric trials should be performed to confirm these original findings. PMID:25149143

  1. Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.

    PubMed

    Sakae, Kensaku; Yanagisawa, Hiroyuki

    2014-06-01

    Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patients with stage II-IV pressure ulcers for ? 8 weeks received 150 mg/day polaprezinc (containing 116 mg L-carnosine and 34 mg zinc) per os for a maximum of 8 weeks. We measured the severity of pressure ulcers weekly using the Pressure Ulcer Scale for Healing (PUSH) score and monitored blood biochemistry. Fourteen patients (nine men; 68.4?±?11.8 years) were enrolled. Pressure ulcer stages were II (one patient; 7 %), III (nine; 64 %), and IV (four; 29 %). The PUSH score improved significantly from 8.1 [95 % CI, 6.0-10.3] at baseline to -1.4 [-4.0 to 1.1] after 8 weeks (P?treatment of pressure ulcers and could be a candidate for their oral treatment. PMID:24691900

  2. Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species.

    PubMed

    Van Acker, Heleen; Sass, Andrea; Bazzini, Silvia; De Roy, Karen; Udine, Claudia; Messiaen, Thomas; Riccardi, Giovanna; Boon, Nico; Nelis, Hans J; Mahenthiralingam, Eshwar; Coenye, Tom

    2013-01-01

    The presence of persister cells has been proposed as a factor in biofilm resilience. In the present study we investigated whether persister cells are present in Burkholderia cepacia complex (Bcc) biofilms, what the molecular basis of antimicrobial tolerance in Bcc persisters is, and how persisters can be eradicated from Bcc biofilms. After treatment of Bcc biofilms with high concentrations of various antibiotics often a small subpopulation survived. To investigate the molecular mechanism of tolerance in this subpopulation, Burkholderia cenocepacia biofilms were treated with 1024 µg/ml of tobramycin. Using ROS-specific staining and flow cytometry, we showed that tobramycin increased ROS production in treated sessile cells. However, approximately 0.1% of all sessile cells survived the treatment. A transcriptome analysis showed that several genes from the tricarboxylic acid cycle and genes involved in the electron transport chain were downregulated. In contrast, genes from the glyoxylate shunt were upregulated. These data indicate that protection against ROS is important for the survival of persisters. To confirm this, we determined the number of persisters in biofilms formed by catalase mutants. The persister fraction in ?katA and ?katB biofilms was significantly reduced, confirming the role of ROS detoxification in persister survival. Pretreatment of B. cenocepacia biofilms with itaconate, an inhibitor of isocitrate lyase (ICL), the first enzyme in the glyoxylate shunt, reduced the persister fraction approx. 10-fold when the biofilms were subsequently treated with tobramycin. In conclusion, most Bcc biofilms contain a significant fraction of persisters that survive treatment with high doses of tobramycin. The surviving persister cells downregulate the TCA cycle to avoid production of ROS and at the same time activate an alternative pathway, the glyoxylate shunt. This pathway may present a novel target for combination therapy. PMID:23516582

  3. Effects of iron polymaltose complex, ferrous fumarate and ferrous sulfate treatments in anemic pregnant rats, their fetuses and placentas.

    PubMed

    Toblli, Jorge E; Cao, Gabriel; Oliveri, Leda; Angerosa, Margarita

    2013-06-01

    Although oral iron preparations are widely prescribed to prevent and to treat iron deficiency anemia in pregnancy, comparative data on their effects to the mother, fetus and placenta are limited. In this study, the effects of oral iron polymaltose complex (IPC), ferrous fumarate (FF) and ferrous sulfate (FS) were compared in anemic pregnant rats, their fetuses and placentas. Hematological variables and oxidative stress markers in the liver, heart and kidneys of the dams and fetuses as well as the markers for oxidative stress, inflammation and hypoxia in placentas were assessed. Pregnancy outcome was measured by number of fetuses, and by neonate and placental weight. All therapies were comparably effective in correcting anemia. FS and FF, but not IPC, resulted in liver damage in dams and oxidative stress in dams, fetuses and placentas. FS group presented the highest catalase and GPx levels in dams, fetuses and placentas. IPC, but not FF or FS, restored normal TNF-? and IL6 expression levels in placentas whereas FS-treated animals presented the highest cytokine levels, suggesting a local inflammatory reaction. Anemia-induced high levels of HIF-1? were partially lowered by IPC and FF but further elevated by FS. Most of the negative effects associated with IDA were resolved by IPC treatment. Especially FS treatment was found to elicit hepatic damage in the dams, oxidative stress in the dams, fetuses and placenta as well as inflammation and high levels of HIF-1? in the placenta. Pregnancy outcome of FFand FS-treated animals was worse than that of IPC-treated animals. PMID:23547731

  4. Adiabatic eigenfunction-based approach for coherent excitation transfer: An almost analytical treatment of the Fenna-Matthews-Olson complex

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Pallavi; Sebastian, K. L.

    2013-06-01

    We suggest a method of studying coherence in finite-level systems coupled to the environment and use it for the Hamiltonian that has been used to describe the light-harvesting pigment-protein complex. The method works with the adiabatic states and transforms the Hamiltonian to a form in which the terms responsible for decoherence and population relaxation are separated out. Decoherence is then accounted for nonperturbatively and population relaxation using a Markovian master equation. Almost analytical results can be obtained for the seven-level system, and the calculations are very simple for systems with more levels. We apply the treatment to the seven-level system, and the results are in excellent agreement with the exact numerical results of Nalbach [Nalbach, Braun, and Thorwart, Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.84.041926 84, 041926 (2011)]. Our approach is able to account for decoherence and population relaxation separately. It is found that decoherence causes only damping of oscillations and does not lead to transfer to the reaction center. Population relaxation is necessary for efficient transfer to the reaction center, in agreement with earlier findings. Our results show that the transformation to the adiabatic basis followed by a Redfield type of approach leads to results in good agreement with exact simulation.

  5. Comparing Two Service Delivery Models for Homeless Individuals With Complex Behavioral Health Needs: Preliminary Data From Two SAMHSA Treatment for Homeless Studies

    Microsoft Academic Search

    M. Scott Young; Colleen Clark; Kathleen Moore; Blake Barrett

    2009-01-01

    Assertive Community Treatment (ACT) and the Comprehensive, Continuous, Integrated System of Care (CCISC) are two models for delivering services to homeless persons with complex behavioral health needs. This quasi-experimental study presents preliminary data comparing these two programs. The first program was based out of a community mental health center and utilized the ACT model of care with supported housing (ACT-SH),

  6. Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice.

    PubMed

    Keller, Benjamin; García-Sevilla, Jesús A

    2015-12-01

    Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-inducing signaling complex (DISC) in the hippocampus (marked changes) and cerebral cortex (modest changes) of KA-treated mice. KA (45mg/kg) induced a severe behavioral syndrome with recurrent motor seizures (scores; maximal at 60-90min; minimal at 72h) with activation of hippocampal pro-apoptotic JNK (+2.5 fold) and increased GFAP (+57%) and nuclear PARP-1 fragmentation (+114%) 72h post-treatment (delayed neurotoxicity). In the extrinsic apoptotic pathway (hippocampus), KA (72h) reduced Fas ligand (-92%) and Fas receptor aggregates (-24%). KA (72h) also altered the contents of major DISC components: decreased FADD adaptor (-44%), reduced activation of initiator caspase-8 (-47%) and increased survival FLIP-S (+220%). Notably, KA (72h) upregulated the content of anti-apoptotic p-Ser191 FADD (+41%) and consequently the expression of p-FADD/FADD ratio (+1.9-fold), a neuroplastic index. Moreover, the p-FADD dependent transcription factor NF-?B was also increased (+61%) in the hippocampus after KA (72h). The convergent adaptation of the extrinsic apoptotic machinery 72h after KA in mice (with otherwise normal gross behavior) is a novel finding which suggests the induction of survival mechanisms to partly counteract the delayed neuronal death in the hippocampus. PMID:26044520

  7. [Modern methods of diagnosis of thrombophylic states and complex treatment of patients with thrombotic complications of severe forms of varicose disease].

    PubMed

    Shchukin, S P

    2014-11-01

    Actual issues of surgical treatment of patients, suffering complications of severe forms of varicose disease of the lower extremities (VDLE) are discussed. The causes of unsatisfactory results of treatment in patients, suffering varicothrombophlebitis (VTHPH), the main of which--absence of the only one tactics for operative treatment and anticoagulant therapy, were analyzed. The results of patients examination, suffering thrombotic complications of severe forms of VDLE, while its recurrent course, in conjunction of VTHPH and thrombosis of deep veins of the lower extremities, using diagnostic complex "PLR genetics thrombophilia", are adduced. Differential tactics of treatment in patients, suffering severe forms of VDLE, while various localization of thrombotic process, concerning the presence of thrombophilic states, is proposed. PMID:25675742

  8. Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-Infected Individuals

    PubMed Central

    Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Khoo, Saye; Merry, Concepta; Van geertruyden, Jean-Pierre

    2011-01-01

    Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for treatment of malaria. The drug combination is highly efficacious against sensitive and multidrug resistant falciparum malaria. Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment. Coadministration of NNRTIs and PIs with AL could potentially cause complex pharmacokinetic drug interactions. NNRTI by inducing CYP450 3A4 enzyme and PIs by inhibiting CYP450 3A4 enzymes could influence both artemether and lumefantrine concentrations and their active metabolites dihydroartemisinin and desbutyl-lumefantrine, predisposing patients to poor treatment response, toxicity, and risk for development of resistance. There are scanty data on these interactions and their consequences. Pharmacokinetic studies to evaluate these interactions in the target populations are urgently needed. PMID:22312573

  9. The sweet spot of forward osmosis: Treatment of produced water, drilling wastewater, and other complex and difficult liquid streams

    E-print Network

    The sweet spot of forward osmosis: Treatment of produced water, drilling wastewater, and other treated by forward osmosis. · Forward osmosis treatment of drilling mud and produced water was evaluated November 2013 Accepted 6 November 2013 Available online xxxx Keywords: Forward osmosis Wastewater treatment

  10. Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study

    SciTech Connect

    Brunetti, A.; Berg, G.; Di Chiro, G.; Cohen, R.M.; Yarchoan, R.; Pizzo, P.A.; Broder, S.; Eddy, J.; Fulham, M.J.; Finn, R.D.

    1989-05-01

    Brain glucose metabolism was evaluated in four patients with acquired immunodeficiency syndrome (AIDS) dementia complex using (/sup 18/F)fluorodeoxyglucose (FDG) and positron emission tomography (PET) scans at the beginning of therapy with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine), and later in the course of therapy. In two patients, baseline, large focal cortical abnormalities of glucose utilization were reversed during the course of therapy. In the other two patients, the initial PET study did not reveal pronounced focal alterations, while the post-treatment scans showed markedly increased cortical glucose metabolism. The improved cortical glucose utilization was accompanied in all patients by immunologic and neurologic improvement. PET-FDG studies can detect cortical metabolic abnormalities associated with AIDS dementia complex, and may be used to monitor the metabolic improvement in response to AZT treatment.

  11. Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis

    Microsoft Academic Search

    Yu-Jeong Kim; Su Young Chae; Cheng-Hao Jin; M. Sivasubramanian; Sohee Son; Ki Young Choi; Dong-Gyu Jo; Kwangmeyung Kim; Ick Chan Kwon; Kang Choon Lee; Jae Hyung Park

    2010-01-01

    The clinical applications of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), an emerging therapeutic protein for cancer and rheumatoid arthritis (RA), are limited by its instability and short biological half-life. In this study, efficient therapeutic modalities for RA treatment were developed in the form of nano-sized complexes (nanocomplexes) based on hyaluronic acid (HA) and polyethylene glycol (PEG)–derivatized TRAIL (PEG–TRAIL)

  12. Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): A Pragmatic Trial of Complex Treatment for a Complex Disorder

    PubMed Central

    Nierenberg, Andrew A.; Sylvia, Louisa G.; Leon, Andrew C.; Reilly-Harrington, Noreen; Shesler, Leah W.; McElroy, Susan L.; Friedman, Edward S.; Thase, Michael E.; Shelton, Richard C.; Bowden, Charles; Tohen, Mauricio; Singh, Vivek; Deckersbach, Thilo; Ketter, Terence; Kocsis, James; McInnis, Melvin G.; Schoenfeld, David; Bobo, William V.; Calabrese, Joseph R.

    2015-01-01

    Background Classic and second generation antipsychotic mood stabilizers are recommended for treatment of bipolar disorder, yet there are no randomized comparative effectiveness studies that have examined the “real-world” advantages and disadvantages of these medications Purpose We describe the strategic decisions in the design of the Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE). This paper outlines the key issues and solutions the investigators faced in designing a clinical trial that would maximize generalizability and inform real-world clinical treatment of bipolar disorder. Methods Bipolar CHOICE was a 6-month, multi-site, prospective, randomized clinical trial of outpatients with bipolar disorder. This study compares the effectiveness of quetiapine versus lithium, each with adjunctive personalized treatments. The co-primary outcomes selected are the overall benefits and harms of the study medications (as measured by the Clinical Global Impression-Efficacy Index) and the Necessary Clinical Adjustments (a measure of the number of medication changes). Secondary outcomes are continuous measures of mood, the Framingham General Cardiovascular Risk Score and the Longitudinal Interval Follow up Evaluation Range of Impaired Functioning Tool. Results The final study design consisted of a single-blind, randomized comparative effectiveness trial of quetiapine versus lithium, plus adjunctive personalized treatment (APT), across ten sites. Other important study considerations included limited exclusion criteria to maximize generalizability, flexible dosing of APT medications to mimic real-world treatment, and an intent-to-treat analysis plan. 482 participants were randomized to the study and 364 completed. Limitations The potential limitations of the study include the heterogeneity of APT, selection of study medications, lack of a placebo-control group, and participants’ ability to pay for study medications. Conclusion We expect that this study will inform our understanding of the benefits and harms of lithium, a classic mood stabilizer, compared to quetiapine, a second generation antipsychotic with broad-spectrum activity in bipolar disorder and will provide an example of a well-designed and well-conducted randomized comparative effectiveness clinical trial. PMID:24346608

  13. Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: A randomized comparison of a simple versus complex strategy

    Microsoft Academic Search

    Manuel Pan; José Suárez de Lezo; Alfonso Medina; Miguel Romero; José Segura; Djordje Pavlovic; Antonio Delgado; Soledad Ojeda; Francisco Melián; Juan Herrador; Isabel Ureńa; Luis Burgos

    2004-01-01

    BackgroundRapamycin-eluting stents (RES) have been shown to reduce restenosis in many types of lesions. However, the ideal strategy for the treatment of coronary bifurcated lesions has not been established to date. This randomized study compares 2 strategies for the RES treatment of bifurcation lesions: a simple approach (stenting the main vessel and balloon dilatation for the side branch [SB]) versus

  14. Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding

    PubMed Central

    2009-01-01

    Introduction Prothrombin complex concentrates are recommended for rapid reversal of vitamin K anticoagulants. As they normalize levels of vitamin K dependent clotting factors and re-establish hemostasis, they may also be used as adjunctive therapy in patients with major bleeding. The aim of this study was to retrospectively evaluate the efficacy of prothrombin complex concentrates in the surgical setting. Methods The case notes of 50 patients requiring urgent oral anticoagulation reversal (n = 12) or with severe perioperative coagulopathic bleeding (n = 38) who received an infusion of prothrombin complex concentrate (Beriplex P/N(R) 500) at the surgical department of the University of Munich Hospital, Germany were retrospectively reviewed. Efficacy of prothrombin complex concentrate application was evaluated using the Quick test, reported as an international normalized ratio, hemodynamic measurements and requirement for blood products. Safety assessments included whole blood hemoglobin levels and specific parameters of organ dysfunction. Results Baseline characteristics were comparable, except that mean baseline international normalized ratio and hemoglobin levels were significantly higher (P < 0.01) in anticoagulation reversal than in bleeding patients. In anticoagulation reversal, the international normalized ratio was significantly reduced (from 2.8 +/- 0.2 at baseline to 1.5 +/- 0.1, P < 0.001) after one prothrombin complex concentrate infusion (median dose 1500 IU; lower quartile 1,000, upper quartile 2,000). No major bleeding was observed during surgery after prothrombin complex concentrate administration. Only one patient received platelets and red blood cell transfusion after prothrombin complex concentrate administration. In bleeding patients, infusion of prothrombin complex concentrate (median dose 2,000 IU; lower quartile 2,000, upper quartile 3,000) significantly reduced the INR from 1.7 +/- 0.1 at baseline to 1.4 +/- 0.1 (P < 0.001). This decrease was unrelated to fresh frozen plasma or vitamin K administration. Bleeding stopped after prothrombin complex concentrate administration in 4/11 (36%) patients with surgical bleeding and 26/27 (96%) patients with diffuse bleeding. Hemoglobin levels increased significantly from baseline in bleeding patients (P < 0.05) and mean arterial pressure stabilized (P < 0.05). No thrombotic events or changes in organ function were reported in any patient. Conclusions Prothrombin complex concentrate application effectively reduced international normalized ratios in anticoagulation reversal, allowing surgical procedures and interventions without major bleeding. In bleeding patients, the improvement in coagulation after prothrombin complex concentrate administration was judged to be clinically significant. PMID:19948037

  15. Colletotrichum truncatum species complex: Treatment considerations and review of the literature for an unusual pathogen causing fungal keratitis and endophthalmitis.

    PubMed

    Squissato, Victoria; Yucel, Yeni H; Richardson, Susan E; Alkhotani, Alaa; Wong, David T; Nijhawan, Navdeep; Chan, Clara C

    2015-09-01

    We present a case of Colletotrichum truncatum species complex fungal keratitis and endophthalmitis in an 87-year-old immunocompetent male in whom oral triazole antifungals were contraindicated. The patient had recently returned from 4 months in Jamaica with a one month history of progressively increasing pain and inflammation in his left eye. Corneal samples grew a filamentous fungus and internal transcribed spacer sequencing polymerase chain reaction confirmed the presence of C. truncatum species complex. Samples showed no microbial growth. PMID:26137437

  16. Colletotrichum truncatum species complex: Treatment considerations and review of the literature for an unusual pathogen causing fungal keratitis and endophthalmitis

    PubMed Central

    Squissato, Victoria; Yucel, Yeni H.; Richardson, Susan E.; Alkhotani, Alaa; Wong, David T.; Nijhawan, Navdeep; Chan, Clara C.

    2015-01-01

    We present a case of Colletotrichum truncatum species complex fungal keratitis and endophthalmitis in an 87-year-old immunocompetent male in whom oral triazole antifungals were contraindicated. The patient had recently returned from 4 months in Jamaica with a one month history of progressively increasing pain and inflammation in his left eye. Corneal samples grew a filamentous fungus and internal transcribed spacer sequencing polymerase chain reaction confirmed the presence of C. truncatum species complex. Samples showed no microbial growth.

  17. Ab initio treatment of the chemical reaction precursor complex Cl(P-2)HF. 2 : Bound states and infrared spectrum

    Microsoft Academic Search

    Anna V. Fishchuk; Gerrit C. Groenenboom; Ad van der Avoird

    2006-01-01

    Bound energy levels and properties of the Cl((2)p)-HF complex were obtained from full three-dimensional (3D) calculations, with the use of the ab initio computed diabatic potential surfaces from the preceding paper and the inclusion of spin-orbit coupling. For a better understanding of the dynamics of this complex we also computed a 21) model in which the HF bond length r

  18. Efficacies of Amphotericin B (AMB) Lipid Complex, AMB Colloidal Dispersion, Liposomal AMB, and Conventional AMB in Treatment of Murine Coccidioidomycosis

    PubMed Central

    González, Gloria M.; Tijerina, Rolando; Najvar, Laura K.; Bocanegra, Rosie; Rinaldi, Michael G.; Graybill, John R.

    2004-01-01

    The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (P < 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (P < 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis. PMID:15155212

  19. Analysis of lignin-carbohydrate and lignin-lignin linkages after hydrolase treatment of xylan-lignin, glucomannan-lignin and glucan-lignin complexes from spruce wood.

    PubMed

    Du, Xueyu; Pérez-Boada, Marta; Fernández, Carmen; Rencoret, Jorge; del Río, José C; Jiménez-Barbero, Jesús; Li, Jiebing; Gutiérrez, Ana; Martínez, Angel T

    2014-05-01

    Xylan-lignin (XL), glucomannan-lignin (GML) and glucan-lignin (GL) complexes were isolated from spruce wood, hydrolyzed with xylanase or endoglucanase/?-glucosidase, and analyzed by analytical pyrolysis and 2D-NMR. The enzymatic hydrolysis removed most of the polysaccharide moieties in the complexes, and the lignin content and relative abundance of lignin-carbohydrate linkages increased. Analytical pyrolysis confirmed the action of the enzymatic hydrolysis, with strong decreases of levoglucosane and other carbohydrate-derived products. Unexpectedly it also revealed that the hydrolase treatment alters the pattern of lignin breakdown products, resulting in higher amounts of coniferyl alcohol. From the anomeric carbohydrate signals in the 2D-NMR spectra, phenyl glycoside linkages (undetectable in the original complexes) could be identified in the hydrolyzed GML complex. Lower amounts of glucuronosyl and benzyl ether linkages were also observed after the hydrolysis. From the 2D-NMR spectra of the hydrolyzed complexes, it was concluded that the lignin in GML is less condensed than in XL due to its higher content in ?-O-4' ether substructures (62 % of side chains in GML vs 53 % in XL) accompanied by more coniferyl alcohol end units (16 vs 13 %). In contrast, the XL lignin has more pinoresinols (11 vs 6 %) and dibenzodioxocins (9 vs 2 %) than the GML (and both have ~13 % phenylcoumarans and 1 % spirodienones). Direct 2D-NMR analysis of the hydrolyzed GL complex was not possible due to its low solubility. However, after sample acetylation, an even less condensed lignin than in the GML complex was found (with up to 72 % ?-O-4' substructures and only 1 % pinoresinols). The study provides evidence for the existence of structurally different lignins associated to hemicelluloses (xylan and glucomannan) and cellulose in spruce wood and, at the same time, offers information on some of the chemical linkages between the above polymers. PMID:24531838

  20. Tautomerism and metal complexation of 2-acylmethyl-2-oxazolines: a combined synthetic, spectroscopic, crystallographic and theoretical treatment.

    PubMed

    Jones, Roderick C; Herasymchuk, Khrystyna; Mahdi, Tayseer; Petrov, Anna; Resanovi?, Sanja; Vaughan, Douglas G; Lough, Alan J; Quail, J Wilson; Koivisto, Bryan D; Wylie, R Stephen; Gossage, Robert A

    2013-06-01

    A synthetic, structural and theoretical investigation into the solid-state, solution and gas phase structure(s) of six 2-acylmethyl-4,4-dimethyl-2-oxazolines is reported. Four of these materials, viz.?-[(4,5-dihydro-4,4-dimethyl-2-oxazolyl)methylene]benzenemethanol (3a), ?-[(4,5-dihydro-4,4-dimethyl-2-oxazolyl)methylene]-(4-nitrobenzene)methanol (3b), 1-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-3,3-dimethyl-1-buten-2-ol (3d) and (E)-1-phenyl-2-((3aR)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d]oxazol-2-ylidene)ethanone (3f) have been characterised in the solid-state by single crystal X-ray diffraction studies. These data represent the first solid-state structural studies of this class of compounds and details the first synthesis and full characterisation of chiral derivative 3f. All four of these materials are shown to exist in the solid phase in the enamine tautomeric form (e.g., 3a is best described as 2-[4,4-dimethyl-2-oxazolidinylidene]-1-phenylethanone) and it is suggested (NMR, IR) that this isomeric form is likely also retained in solution (e.g., CDCl3) as the more stable isomer. An investigation of the relative gas phase stabilities of the three possible (i.e., the (Z)-enol, keto and enamine) isomers of all five compounds by DFT at the B3LYP/6-311G(d) level of theory confirms the latter as the most stable form. The energy differences between the enamine and keto tautomers have been calculated to be the lowest for derivative 3d. These results are compared and contrasted with the previously reported NMR studies of such compounds which have identified the keto form as being a minor (albeit solution) tautomer. Equilibrium solution tautomer distributions for 3d are found to be solvent dependent. The protonated form of 3a, isolated as the HSO4(-) salt (i.e.4a), has been further characterised in the solid state by single crystal X-ray diffraction. These data represent the first example of a protonated oxazoline to be structurally elucidated and confirms that upon protonation, the keto (oxazoline) tautomer is the energetically favoured form in the solid-state. This observation is further supported by DFT studies for the gas phase protonated forms of such materials. Further DFT (B3LYP/6-311G(d)) calculations employing the SM8 or SMD solvation models were then applied to address the observed solution isomeric distribution for 3d; these results corroborate the gas phase theoretical treatment and also yield values that predict the higher solution stability of the enamine form as observed, although they fail to account for the existence of the keto form as a minor solution state tautomer. To access the availability of an enol-form, via hypothetical de-protonation to the enolate, compound 3a was treated with hydrated Cu(NO3)2 in EtOH solution. The resulting isolated green-coloured product (5), the first metal derivative of this entire class of ligands, is best described (IR, X-ray diffraction) as a coordinated enolate complex, i.e., Cu(3a-H)2. Complex 5 crystallizes in the P21/c space group with four molecules in the unit cell. The coordination geometry around the formal Cu(2+) metal centre is determined to be highly distorted square planar in nature (?4 = 0.442). TD-DFT is used to give a reasonable explanation for the intensity of the absorbance band observed in the visible region for solutions of 5. These latter experiments strongly suggest that the title class of compounds may have considerable potential as ligands in coordination chemistry and/or metal-mediated catalysis. PMID:23591452

  1. Comparative effectiveness of a complex Ayurvedic treatment and conventional standard care in osteoarthritis of the knee – study protocol for a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Traditional Indian Ayurvedic medicine uses complex treatment approaches, including manual therapies, lifestyle and nutritional advice, dietary supplements, medication, yoga, and purification techniques. Ayurvedic strategies are often used to treat osteoarthritis (OA) of the knee; however, no systematic data are available on their effectiveness in comparison with standard care. The aim of this study is to evaluate the effectiveness of complex Ayurvedic treatment in comparison with conventional methods of treating OA symptoms in patients with knee osteoarthritis. Methods and design In a prospective, multicenter, randomized controlled trial, 150 patients between 40 and 70 years, diagnosed with osteoarthritis of the knee, following American College of Rheumatology criteria and an average pain intensity of ?40 mm on a 100 mm visual analog scale in the affected knee at baseline will be randomized into two groups. In the Ayurveda group, treatment will include tailored combinations of manual treatments, massages, dietary and lifestyle advice, consideration of selected foods, nutritional supplements, yoga posture advice, and knee massage. Patients in the conventional group will receive self-care advice, pain medication, weight-loss advice (if overweight), and physiotherapy following current international guidelines. Both groups will receive 15 treatment sessions over 12 weeks. Outcomes will be evaluated after 6 and 12 weeks and 6 and 12 months. The primary endpoint is a change in the score on the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) after 12 weeks. Secondary outcome measurements will use WOMAC subscales, a pain disability index, a visual analog scale for pain and sleep quality, a pain experience scale, a quality-of-life index, a profile of mood states, and Likert scales for patient satisfaction, patient diaries, and safety. Using an adapted PRECIS scale, the trial was identified as lying mainly in the middle of the efficacy-effectiveness continuum. Discussion This trial is the first to compare the effectiveness of a complex Ayurvedic intervention with a complex conventional intervention in a Western medical setting in patients with knee osteoarthritis. During the trial design, aspects of efficacy and effectiveness were discussed. The resulting design is a compromise between rigor and pragmatism. Trial registration NCT01225133 PMID:23701973

  2. Treatment of simple and complex endometrial non-atypical hyperplasia with natural progesterone: response rate to different doses.

    PubMed

    Marra, Chiara; Penati, Cristina; Ferrari, Luisa; Cantů, Maria Grazia; Bargossi, Lorena; Fruscio, Robert

    2014-08-11

    Abstract The aim of this study is to evaluate the response rate to natural progesterone in non-atypical endometrial hyperplasia and to identify the lowest effective dose. A total of 197 patients of childbearing age with simple or complex hyperplasia were retrospectively identified. The women were treated with a cyclic administration of progesterone at different dosages (100 versus 200 versus 300?mg daily). Endometrial biopsies were performed at 6, 12, 18 months. In comparing progesterone to a regimen of no therapy, a significantly higher remission rate was observed in the progesterone group than in the latter (95 versus 75%, p?=?0.05 for simple hyperplasia; 89 versus 35%, p?complex hyperplasia). Out of 60 women with simple hyperplasia, remission was observed in 9/11 (81.8%), 40/41 (97.5%) and 8/8 (100%) patients treated, respectively, with progesterone 100, 200 and 300?mg daily. Out of 72 women with complex hyperplasia, remission was observed in 3/5 (60%), 49/53 (92.4%) and 12/14 (85.7%) patients treated with progesterone 100, 200 and 300?mg daily, respectively. There was no statistically significant difference in the response rate in the two groups, neither with simple nor with complex hyperplasia. In conclusion, progesterone increased the regression rate of both simple and complex hyperplasia. PMID:25111756

  3. Complex decongestive physical therapy and low-level laser therapy for the treatment of pediatric congenital lymphedema: a case report

    PubMed Central

    Hwang, Woon Taek; Chung, Sin Ho; Lee, Ju Sang

    2015-01-01

    [Purpose] We report the case of a pediatric patient with congenital lymphedema treated with complex decongestive physical therapy and low-level laser therapy. [Subjects and Methods] The patient was a 2?year-old girl who had lymphedema in the left upper limb since birth. Complex decongestive physical therapy and low-level laser therapy were administered for 7 sessions. [Results] The circumferences of the middle of the forearm, elbow joint, wrist, and hand of the left upper limb decreased 0.5, 3, 0.5, and 2?cm, respectively. The moisture content of the left upper limb decreased 70?mL (6.66%), while moisture ratio increased by 0.007%. [Conclusion] Complex decongestive physical therapy and low-level laser therapy are effective for reducing lymphedema in pediatric patients. PMID:26180372

  4. A complete mass balance of a complex combined anaerobic/aerobic municipal source-separated waste treatment plant.

    PubMed

    Pognani, Michele; Barrena, Raquel; Font, Xavier; Sánchez, Antoni

    2012-05-01

    In this study a combined anaerobic/aerobic full-scale treatment plant designed for the treatment of the source-separated organic fraction of municipal solid waste (OFMSW) was monitored over a period of one year. During this period, full information was collected about the waste input material, the biogas production, the main rejects and the compost characteristics. The plant includes mechanical pre-treatment, dry thermophilic anaerobic digestion, tunnel composting system and a curing phase to produce compost. To perform the monitoring of the entire plant and the individual steps, traditional chemical methods were used but they present important limitations in determining the critical points and the efficiency of the stabilization of the organic matter. Respiration indices (dynamic and cumulative) allowed for the quantitative calculation of the efficiency of each treatment unit. The mass balance was calculated and expressed in terms of Mgy(-1) of wet (total) matter, carbon, nitrogen and phosphorus. Results show that during the pre-treatment step about 32% of the initial wet matter is rejected without any treatment. This also reduces the biodegradability of the organic matter that continues to the treatment process. About 50% of the initial nitrogen and 86.4% of the initial phosphorus are found in the final compost. The final compost also achieves a high level of stabilization with a dynamic respiration index of 0.3±0.1g O(2) per kg of total solids per hour, which implies a reduction of 93% from that of the raw OFMSW, without considering the losses of biodegradable organic matter in the refuse (32% of the total input). The anaerobic digestion process is the main contributor to this stabilization. PMID:22261421

  5. [Chemotherapy and biological treatment in the complex management of large intestinal and rectal carcinomas. When, why, how?].

    PubMed

    Kubala, E; Petruzelka, L; Sedlácková, E

    2009-06-01

    The colorectal cancer treatment has significantly changed in last few years. Use of new drugs such as oxaliplatin, irinotecan, or capecitabine improved long term survival of patient with this disease. Research of biologic and genetic behavior of CRC has brought new ways in therapy called "biologic therapy". Standard today's treatment consist of three drugs: bevacizumab (antiVEGF antibody), cetuximab and panitumimab (anti EGFR antibodies). Biology therapy should be used simultaneously with chemotherapy only and after genetic examination of the cancer (K ras mutation). For patients with stage III the adjuvant therapy with combination of FOLFOX (oxaliplatin, fluorouracil, and leukovorin) is recommended to reduce the probability of recurrence and improve survival. In stage IIB there is a clear need to determine further risks which classify the high risk patients who should be enrolled in adjuvant chemotherapy. In palliative treatment of colorectal cancer there are several chemotherapy combinations (FUFA, FOLFOX, FOLFIRI, XELOX, XELIRI) used with biologic therapy. International recommendation for the biologic therapy is in the first line treatment bevacizumab and cetuximab or panitumumab in the second line is recommended. The new discoveries in biology of colorectal cancer show the need of tailoring. PMID:19642320

  6. COMPLEX ANALYTICAL PROCEDURE FOR THE CHARACTERIZATON OF MODIFIED ZEOLIZE AND FOR THE ASSESSMENT ITS EFFECTS ON BIOLOGICAL WASTEWATER TREATMENT

    Microsoft Academic Search

    Peter Princz; József Oláh; Scot Smith; Kirk Hatfield

    Under a joint US-Hungarian R&D project financed by the NATO Science for Peace Programme an innovative zeolite modification method and a wastewater treatment technology based on the application of zeolite modified with cation active polyelectrolyte (CAP) were developed between 1999 and 2002 (1). In order to determine the chemical composition and the stability of the CAP modified zeolite (SMZ), as

  7. Comparison of Wallgraft and Wallstent for treatment of complex iliac artery stenosis and occlusion. Preliminary results of a prospective randomized study.

    PubMed Central

    Krajcer, Z; Sioco, G; Reynolds, T

    1997-01-01

    We performed a prospective randomized study to compare the use of a bare metal stent (WALLSTENT Endoprosthesis) with use of a covered stent (WALLGRAFT Endoprosthesis)-both made by Schneider, Inc.; Minneapolis, Minn-for the treatment of complex iliac artery stenosis and occlusion. We report the preliminary results of a study performed at our institution from 1 February 1997 through 31 April 1997. The patient group was composed of 6 women and 4 men, with a mean age of 61.8 years (range, 47 to 73 years). Six WALLGRAFT endoprostheses (4 in the left iliac artery and 2 in the right) and 9 WALLSTENT endoprostheses (5 in the left iliac artery and 4 in the right) were implanted. The mean percent stenosis before treatment was similar in both groups (84.17% in the WALLGRAFT group and 82.14% in the WALLSTENT group). The post-treatment stenosis and peak systolic gradients were negligible or zero in both groups. The devices were safely deployed and technical success (< 30% residual stenosis) was achieved in both groups. The mean thigh-brachial index was similar in the 2 groups, both before treatment (0.65 in the WALLGRAFT group and 0.64 in the WALLSTENT group) and after treatment (1.12 in the WALLGRAFT group and 1.12 in the WALLSTENT group). Evaluation of clinical success revealed that symptoms of intermittent claudication improved markedly in 4 of 5 patients who received the WALLGRAFT Endoprosthesis. In the WALLSTENT group, 1 patient had symptomatic improvement, another had 1 limb improve and the other worsen, and the rest had no improvement. Clinical complications were observed in only 1 patient in the WALLGRAFT group and in 2 patients in the WALLSTENT group. These preliminary results indicate very good technical and early success at the 1-month follow-up with the use of the WALLGRAFT Endoprosthesis in complex iliac artery stenosis and occlusion. Despite these promising preliminary results, a longer follow-up study with a larger number of patients is needed to determine the benefits of the WALLGRAFT Endoprosthesis in patients with complex iliac artery stenosis or occlusion. Images PMID:9339507

  8. Thermal treatment effects imposed on solid DNA cationic lipid complex with hexadecyltrimethylammonium chloride, observed by variable angle spectroscopic ellipsometry

    NASA Astrophysics Data System (ADS)

    Nizio?, Jacek

    2014-12-01

    DNA cationic lipid complexes are materials of properties required for applications in organic electronics and optoelectronics. Often, their thermal stability demonstrated by thermogravimetry is cited in the literature as important issue. However, little is known about processes occurring in heated solid DNA cationic lipid complexes. In frame of this work, thin films of Deoxyribonucleic acid-hexadecyltrimethylammonium chloride (DNA-CTMA) were deposited on silicon wafers. Samples were thermally annealed, and simultaneously, their optical functions were measured by spectroscopic ellipsometry. At lower temperatures, thermal expansion coefficient of solid DNA-CTMA was negative, but at higher temperatures positive. Thermally induced modification of absorption spectrum in UV-vis was observed. It occurred at a range of temperatures higher than this of DNA denaturation in solution. The observed phenomenon was irreversible, at least in time scale of the experiment (one day).

  9. Minimization of round-off error and treatment of single phase and separated components in conventional and complex columns 

    E-print Network

    Weisenfelder, Andrew J

    1961-01-01

    . . . . . . . 28 30 ENTHALPY BAIANCES 31 ILLUSTRATIVE EXAMPLES . 32 CONCLUSIONS 35 TABLE OF NOTATION 36 BIBLIOGRAPHY APPENDIX . 40 42 LIST OF ILLUSTRATIONS Figure Page 1. Diagram of a Complex Column with Two Feed Plates and Two Side Streams... Specifications for Examples 1 Through 12. . . . . . . . . . . . 47 V Results of 8-Method and Bubble Points for Feeds Containing Large Percentages of Light Components. 49 VI Solution of Example 9 Which Contained a Single Phase Light Component 50 VII Solution...

  10. Lapita Burial Practices: Evidence for Complex Body and Bone Treatment at the Teouma Cemetery, Vanuatu, Southwest Pacific

    Microsoft Academic Search

    Frédérique Valentin; Stuart Bedford; Hallie R. Buckley; Matthew Spriggs

    2010-01-01

    Excavation of the 3,000-year-old Lapita cemetery of Teouma (Efate, Central Vanuatu) has allowed the first detailed investigation of mortuary practices of these initial colonizers of the Vanuatu archipelago. Focusing on one component of funerary practice: the adult corpse and bone treatment of 25 mortuary contexts recovered at the site during excavations in 2004 and 2005, the present study reveals that

  11. Application of the upflow anaerobic sludge bed (UASB) process for treatment of complex wastewaters at low temperatures

    SciTech Connect

    Koster, I.W.; Lettinga, G.

    1985-10-01

    The feasibility of the upflow anaerobic sludge bed (UASB) process for the treatment of potato starch wastewater at low ambient temperatures was demonstrated by operating two 5.65 l reactors at 14 degrees C and 20 degrees C, respectively. The organic space loading rates achieved in these laboratory-scale reactors were 3 kg COD/cubic m/day at 14 degrees C and 4-5 kg COD/cubic m/day at 20 degrees C. The corresponding sludge loading rates were 0.12 kg COD/kg VSS/day at 14 degrees C and 0.16-0.18 kg COD/kg VSS/day at 20 degrees C. These findings are of considerable practical importance because application of anaerobic treatment at low ambient temperatures will lead to considerable savings in energy needed for operating the process. As compared with various other anaerobic wastewater treatment processes, a granular sludge upflow process represents one of the best options developed so far. Although the overall sludge yield under psychrophilic conditions is slightly higher than under optimal mesophilic conditions, this doesn't seriously hamper the operation of the process. The extra sludge yield, due to accumulation of slowly hydrolyzing substrate ingredients, was 4.75% of the COD input at 14 degrees C and 1.22% of the COD input at 20 degrees C. 26 references.

  12. Vanadium and cancer treatment: antitumoral mechanisms of three oxidovanadium(IV) complexes on a human osteosarcoma cell line.

    PubMed

    León, I E; Butenko, N; Di Virgilio, A L; Muglia, C I; Baran, E J; Cavaco, I; Etcheverry, S B

    2014-05-01

    We report herein the antitumor actions of three oxidovanadium(IV) complexes on MG-63 human osteosarcoma cell line. The three complexes: VO(oda), VO(oda)bipy and VO(oda)phen (oda=oxodiacetate), caused a concentration dependent inhibition of cell viability. The antiproliferative action of VO(oda)phen could be observed in the whole range of concentrations (at 2.5 ?M), while VO(oda)bipy and VO(oda) showed a decrease of cell viability only at higher concentrations (at 50 and 75 ?M, respectively) (p<0.01). Moreover, VO(oda)phen caused a decrease of lysosomal and mitochondrial activities at 2.5 ?M, while VO(oda) and VO(oda)bipy affected neutral red uptake and mitochondrial metabolism at 50 ?M (p<0.01). On the other hand, no DNA damage studied by the Comet assay could be observed in MG-63 cells treated with VO(oda) at 2.5-10 ?M. Nevertheless, VO(oda)phen and VO(oda)bipy induced DNA damage at 2.5 and 10 ?M, respectively (p<0.01). The generation of reactive oxygen species increased at 10 ?M of VO(oda)phen and only at 100 ?M of VO(oda) and VO(oda)bipy (p<0.01). Besides, VO(oda)phen and VO(oda)bipy triggered apoptosis as determined by externalization of the phosphatidylserine. The determination of DNA cleavage by agarose gel electrophoresis showed that the ability of VO(oda)(bipy) is similar to that of VO(oda), while VO(oda)(phen) showed the highest nuclease activity in this series. Overall, our results showed a good relationship between the bioactivity of the complexes and their structures since VO(oda)phen presented the most potent antitumor action in human osteosarcoma cells followed by VO(oda)bipy and then by VO(oda) according to the number of intercalating heterocyclic moieties. PMID:24199985

  13. Ab initio treatment of the chemical reaction precursor complex Cl(2P)-HF. 2. Bound states and infrared spectrum.

    PubMed

    Fishchuk, Anna V; Groenenboom, Gerrit C; van der Avoird, Ad

    2006-04-27

    Bound energy levels and properties of the Cl(2P)-HF complex were obtained from full three-dimensional (3D) calculations, with the use of the ab initio computed diabatic potential surfaces from the preceding paper and the inclusion of spin-orbit coupling. For a better understanding of the dynamics of this complex we also computed a 2D model in which the HF bond length r was frozen at the vibrationally averaged values r0 and r1 and a 2 + 1D model in which the 3D potentials were averaged over the v(HF) = 0 and v(HF) = 1 vibrational wave functions of free HF. Also 1D calculations were made in which both r and the Cl-HF distance R were frozen. The complex is found to have the linear hydrogen bonded Cl-HF structure, with ground-state quantum numbers J = 3/2 for the overall angular momentum and /omega/ = 3/2 for its projection on the intermolecular axis R. The binding energy is D0 = 432.25 cm(-1) for v(HF) = 0 and D0 = 497.21 cm(-1) for v(HF) = 1. Bending modes with /omega/ = 1/2 and /omega/ = 5/2 are split by the Renner-Teller effect, since the electronic ground state is a degenerate 2pi state. A series of intermolecular (R) stretch modes was identified. Rotational constants and e-f parity splittings were extracted from the levels computed for J = 1/2 to 7/2. The computed red shift of the HF stretch frequency of 64.96 cm(-1) and the 35Cl-37Cl isotope shift of 0.033 cm(-1) are in good agreement with the values of 68.77 and 0.035 cm(-1) obtained from the recent experiment of Merritt et al. (Phys. Chem. Chem. Phys. 2005, 7, 67), after correction for the effect of the He nanodroplet matrix in which they were measured. PMID:16623453

  14. New fly ash TiO2 composite for the sustainable treatment of wastewater with complex pollutants load

    NASA Astrophysics Data System (ADS)

    Visa, Maria; Isac, Luminita; Duta, Anca

    2015-06-01

    The goal of this paper was to develop a new composite obtained in mild hydrothermal conditions starting from fly ash (a waste raising significant environmental problems), and TiO2. The composite was characterized through XRD, SEM/EDX, AFM, and BET surface measurements. The composite was further used for the advanced treatment of wastewaters with multiple-pollutants load. The photocatalytic efficiency of the powder composite was tested on synthetic solutions containing a heavy metal cation (copper), a dye (methyl orange), and a surfactant (sodium dodecylbenzenesulfonate), under UV and simulated solar radiation. Comparative experiments were done in systems with and without H2O2 showing a significant increase in efficiency for methyl orange removal from mono-, bi-, and tri-pollutants solutions. The process parameters were optimized and the adsorption mechanisms are discussed, outlining that adsorption is the limiting step. Experiments also outlined that homogeneous photocatalysis (using H2O2) is less efficient then the heterogeneous process using the novel composite, both under UV and simulated solar radiation.

  15. Advanced monitoring and supervision of biological treatment of complex dairy effluents in a full-scale plant.

    PubMed

    Carrasco, Eugenio F; Omil, Francisco; Garrido, Juan M; Arrojo, Belén; Méndez, Ramón

    2004-01-01

    The operation of a wastewater treatment plant treating effluents from a dairy laboratory was monitored by an advanced system. This plant comprises a 12 m(3) anaerobic filter (AF) reactor and a 28 m(3) sequential batch reactor (SBR) coupled in series and is equipped with the following on-line measurement devices: biogas flow meter, feed and recycling flow meters, temperature sensor, dissolved oxygen analyzer, and redox meter. Other parameters such as chemical oxygen demand (COD), volatile fatty acids (VFA), etc. were determined off-line. The plant has been in operation for 634 days, the influent flow rate being 6-8 m(3)/d. COD concentration of the influent ranged between 8 and 12 kg COD/m(3), resulting in COD values in the effluent around 50-200 mg/L. The behavior of the system was studied using the set of measurements collected by the data acquisition program especially developed for this purpose. Monitoring of variables such as anaerobic reactor temperature permitted the detection and prevention of several failures such as temperature shocks in the AF reactor. Besides, off-line measurements such as the alkalinity or the VFA content, together with the on-line measurements, provided immediate information about the state of the plant and the detection of several anomalies, such as organic overloads in the SBR, allowing the implementation of several fast control actions. PMID:15176911

  16. The Ilizarov method for the treatment of complex tibial fractures and non-unions in a mass casualty setting: the 2005 earthquake in Pakistan.

    PubMed

    Tilkeridis, Konstantinos; Chari, Basavraj; Cheema, Nusrat; Tryfonidis, Marios; Khaleel, Arshad

    2015-04-01

    We report our experience in treating victims of the recent earthquake disaster in Pakistan. Our experience was based on two humanitarian missions to Islamabad: one in October 2005, 10 days after the earthquake, and the second in January 2006. The mission consisted of a team of orthopaedic surgeons and a second team of plastic surgeons. The orthopaedic team bought all the equipment for application of Ilizarov external fixators. We treated patients who had already received basic treatment in the region of the disaster and subsequently had been evacuated to Islamabad. During the first visit, we treated 12 injured limbs in 11 patients. Four of these patients were children. All cases consisted of complex multifragmentary fractures associated with severe crush injuries. All fractures involved the tibia, which were treated with Ilizarov external fixators. Nine fractures were type 3b open injuries. Eight were infected requiring debridement of infected bone and acute shortening. During a second visit, we reviewed all patients treated during our first mission. In addition, we treated 13 new patients with complex non-unions. Eight of these patients were deemed to be infected. All patients had previous treatment with monolateral fixators as well as soft tissue coverage procedures, except one patient who had had an IEF applied by another team. All these patients had revision surgery with circular frames. All patients from both groups were allowed to fully weight-bear post-operatively, after a short period of elevation to allow the flaps to take. Overall, all fractures united except one case who eventually had an amputation. Four patients had a corticotomy and lengthening, and three of them had a successful restoration of limb length. The fourth patient was the one with the eventual amputation. PMID:25764152

  17. Constructing a Theory- and Evidence-Based Treatment Rationale for Complex eHealth Interventions: Development of an Online Alcohol Intervention Using an Intervention Mapping Approach

    PubMed Central

    Johansen, Ayna; Nesvĺg, Sverre; Kok, Gerjo; Duckert, Fanny

    2013-01-01

    Background Due to limited reporting of intervention rationale, little is known about what distinguishes a good intervention from a poor one. To support improved design, there is a need for comprehensive reports on novel and complex theory-based interventions. Specifically, the emerging trend of just-in-time tailoring of content in response to change in target behavior or emotional state is promising. Objective The objective of this study was to give a systematic and comprehensive description of the treatment rationale of an online alcohol intervention called Balance. Methods We used the intervention mapping protocol to describe the treatment rationale of Balance. The intervention targets at-risk drinking, and it is delivered by email, mobile phone text messaging, and tailored interactive webpages combining text, pictures, and prerecorded audio. Results The rationale of the current treatment was derived from a self-regulation perspective, and the overarching idea was to support continued self-regulation throughout the behavior change process. Maintaining the change efforts over time and coping adaptively during critical moments (eg, immediately before and after a lapse) are key factors to successful behavior change. Important elements of the treatment rationale to achieving these elements were: (1) emotion regulation as an inoculation strategy against self-regulation failure, (2) avoiding lapses by adaptive coping, and (3) avoiding relapse by resuming the change efforts after a lapse. Two distinct and complementary delivery strategies were used, including a day-to-day tunnel approach in combination with just-in-time therapy. The tunnel strategy was in accordance with the need for continuous self-regulation and it functions as a platform from which just-in-time therapy was launched. Just-in-time therapy was used to support coping during critical moments, and started when the client reports either low self-efficacy or that they were drinking above target levels. Conclusions The descriptions of the treatment rationale for Balance, the alcohol intervention reported herein, provides an intervention blueprint that will aid in interpreting the results from future program evaluations. It will ease comparisons of program rationales across interventions, and may assist intervention development. By putting just-in-time therapy within a complete theoretical and practical context, including the tunnel delivery strategy and the self-regulation perspective, we have contributed to an understanding of how multiple delivery strategies in eHealth interventions can be combined. Additionally, this is a call for action to improve the reporting practices within eHealth research. Possible ways to achieve such improvement include using a systematic and structured approach, and for intervention reports to be published after peer-review and separately from evaluation reports. PMID:23612478

  18. Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening.

    PubMed

    Trelinska, Joanna; Dachowska, Iwona; Kotulska, Katarzyna; Fendler, Wojciech; Jozwiak, Sergiusz; Mlynarski, Wojciech

    2015-04-01

    The aim of this study was to evaluate the most common adverse events (AEs) linked to everolimus therapy, a mammalian target of rapamycin (mTOR) inhibitor, in children and adolescents with tuberous sclerosis complex (TSC) hospitalized in one medical center. The study group included 18 patients with a diagnosis of subependymal giant cell astrocytoma or renal angiomyolipoma related to TSC. The median duration of therapy was 15 months. All clinical symptoms and laboratory abnormalities including complete blood count, fasting lipid profile, glucose level, and liver and kidney function tests were analyzed as potential AEs. The most common AEs of everolimus therapy were laboratory abnormalities (100% of patients) and infection complications (83 episodes in 15 patients). Infectious episodes of pharyngitis (67%), diarrhea (44%), stomatitis (39%), and bronchitis (39%) were the most common infections. They were mostly mild or moderate in severity (grade 1-2). In two cases, life-threatening conditions related to mTOR inhibitor treatment were encountered. The first was classified as grade 4 pleuropneumonia and Streptococcus pneumoniae sepsis, whereas the second was classified as death related to AE (grade 5) Escherichia coli sepsis. The most common laboratory abnormalities were hypercholesterolemia (13/18 patients - 72%) and hypertriglyceridemia (12/18 patients - 66%). Neutropenia (12/18 patents - 66%) and anemia (8/18 patients - 44%) were the most common hematologic toxicities. Everolimus treatment in TSC patients may lead to life-threatening outcomes, including sepsis and death. Long-lasting effects of everolimus treatment in the context of high incidences of different laboratory abnormalities found in TSC patients are another subject that should be researched further. PMID:25719621

  19. Pilot Quasi-Randomized Controlled Study of Herbal Medicine Hochuekkito as an Adjunct to Conventional Treatment for Progressed Pulmonary Mycobacterium avium Complex Disease

    PubMed Central

    Enomoto, Yasunori; Hagiwara, Eri; Komatsu, Shigeru; Nishihira, Ryuichi; Baba, Tomohisa; Kitamura, Hideya; Sekine, Akimasa; Nakazawa, Atsuhito; Ogura, Takashi

    2014-01-01

    Introduction Hochuekkito, a traditional herbal medicine, is occasionally prescribed in Japan to treat patients with a poor general condition. We aimed to examine whether this medicine was beneficial and tolerable for patients with progressed pulmonary Mycobacterium avium complex (MAC) disease. Methods This pilot open-label quasi-randomized controlled trial enrolled 18 patients with progressed pulmonary MAC disease who had initiated antimycobacterial treatment over one year ago but were persistently culture-positive or intolerant. All patients continued their baseline treatment regimens with (n?=?9) or without (n?=?9) oral Hochuekkito for 24 weeks. Results Baseline characteristics were generally similar between the groups. Most patients were elderly (median age 70 years), female, had a low body mass index (<20 kg/m2), and a long-term disease duration (median approximately 8 years). After the 24-week treatment period, no patient achieved sputum conversion. Although the number of colonies in sputum tended to increase in the control group, it generally remained stable in the Hochuekkito group. Radiological disease control was frequently observed in the Hochuekkito group than the control group (8/9 vs. 3/9; p?=?0.05). Patients in the Hochuekkito group tended to experience increase in body weight and serum albumin level compared with those in the control group (median body weight change: +0.4 kg vs. ?0.8 kg; median albumin change: +0.2 g/dl vs. ±0.0 g/dl). No severe adverse events occurred. Conclusions Hochuekkito could be an effective, feasible adjunct to conventional therapy for patients with progressed pulmonary MAC disease. Future study is needed to explore this possibility. Trial Registration UMIN Clinical Trials Registry UMIN000009920 PMID:25093868

  20. Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion: A Drug Complex of Natural Extracts and Inorganic Compounds

    PubMed Central

    Lupfer, Christopher; Besnouin, Didier; Tepper, Samuel E.; Maselko, Maciej; Patton, Kristin M.; Pastey, Manoj

    2011-01-01

    Ekybion is a drug complex of 16 natural extracts and inorganic compounds designed to treat a variety of respiratory pathogens of bacterial and viral origin. It is licensed throughout Europe for the treatment of respiratory tract infections from equine parainfluenza type 3 and equine herpes virus type 1 in equine stables. The purpose of this paper was to test the efficacy of Ekybion on a well-developed animal model of influenza A infection and determine a mode of action. Experiments were performed with Balb/c mice infected with a lethal dose of influenza A/PR/8/34 H1N1 virus and treated with nebulized Ekybion every 8?h in a time-dependant or dose-dependant fashion. These experiments showed that mice treated prior to infection with Ekybion had a higher survival rates (~46%) compared with untreated animals (~0%). Paradoxically, these mice showed no significant difference in lung virus titer or weight loss. There was, however, a decrease in the level of GM-CSF, IL-6, and G-CSF cytokines in the lungs of Ekybion-treated, infected mice. It is possible that decreases in proinflammatory cytokines may have contributed to increased survivorship in Ekybion-treated influenza-infected mice. PMID:20981272

  1. Fast and accurate Monte Carlo modeling of a kilovoltage X-ray therapy unit using a photon-source approximation for treatment planning in complex media.

    PubMed

    Zeinali-Rafsanjani, B; Mosleh-Shirazi, M A; Faghihi, R; Karbasi, S; Mosalaei, A

    2015-01-01

    To accurately recompute dose distributions in chest-wall radiotherapy with 120 kVp kilovoltage X-rays, an MCNP4C Monte Carlo model is presented using a fast method that obviates the need to fully model the tube components. To validate the model, half-value layer (HVL), percentage depth doses (PDDs) and beam profiles were measured. Dose measurements were performed for a more complex situation using thermoluminescence dosimeters (TLDs) placed within a Rando phantom. The measured and computed first and second HVLs were 3.8, 10.3 mm Al and 3.8, 10.6 mm Al, respectively. The differences between measured and calculated PDDs and beam profiles in water were within 2 mm/2% for all data points. In the Rando phantom, differences for majority of data points were within 2%. The proposed model offered an approximately 9500-fold reduced run time compared to the conventional full simulation. The acceptable agreement, based on international criteria, between the simulations and the measurements validates the accuracy of the model for its use in treatment planning and radiobiological modeling studies of superficial therapies including chest-wall irradiation using kilovoltage beam. PMID:26170553

  2. In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model

    PubMed Central

    2010-01-01

    Background Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. Methods Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. Results We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. Conclusion The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies. PMID:20338038

  3. Fast and accurate Monte Carlo modeling of a kilovoltage X-ray therapy unit using a photon-source approximation for treatment planning in complex media

    PubMed Central

    Zeinali-Rafsanjani, B.; Mosleh-Shirazi, M. A.; Faghihi, R.; Karbasi, S.; Mosalaei, A.

    2015-01-01

    To accurately recompute dose distributions in chest-wall radiotherapy with 120 kVp kilovoltage X-rays, an MCNP4C Monte Carlo model is presented using a fast method that obviates the need to fully model the tube components. To validate the model, half-value layer (HVL), percentage depth doses (PDDs) and beam profiles were measured. Dose measurements were performed for a more complex situation using thermoluminescence dosimeters (TLDs) placed within a Rando phantom. The measured and computed first and second HVLs were 3.8, 10.3 mm Al and 3.8, 10.6 mm Al, respectively. The differences between measured and calculated PDDs and beam profiles in water were within 2 mm/2% for all data points. In the Rando phantom, differences for majority of data points were within 2%. The proposed model offered an approximately 9500-fold reduced run time compared to the conventional full simulation. The acceptable agreement, based on international criteria, between the simulations and the measurements validates the accuracy of the model for its use in treatment planning and radiobiological modeling studies of superficial therapies including chest-wall irradiation using kilovoltage beam. PMID:26170553

  4. In vivo formation of sigma-methyl- and sigma-phenyl-ferric complexes of hemoglobin and liver-cytochrome P-450 upon treatment of rats with methyl- and phenylhydrazine.

    PubMed

    Delaforge, M; Battioni, P; Mahy, J P; Mansuy, D

    1986-10-15

    Ferric sigma-phenyl complexes of hemoglobin and liver cytochrome P-450 are formed in vivo upon administration of C6H5NHNH2 to rats. Small amounts of the sigma-methyl complex of hemoglobin were also detected in vivo upon treatment of rats with CH3NHNH2. At the doses used for CH3NHNH2 (25 and 50 mg/kg) the states and levels of hemoglobin in the blood and spleen, and of cytochrome P-450 in the liver were almost unchanged. On the contrary, C6H5NHNH2 (25-100 mg/kg) led to a decrease of the HbO2 blood level (10-50%), together with an increase in the HbFe(III) level and the appearance of the HbFe(III)-C6H5 complex. The concentration of this complex reaches its maximum value (2 mM) 1 h after C6H5NHNH2 administration (20% of total hemoglobin). At the same time large amounts of HbO2, HbFe(III) and HbFe(III)-C6H5 appeared in the spleen, and remained high up to 24 h after treatment. Treatment of rats with C6H5NHNH2 (25-100 mg/kg) led to a significant decrease in the level of liver cytochrome P-450 (a 70% decrease 2 h after treatment with 100 mg/kg C6H5NHNH2). About 15% of the remaining cytochrome P-450 existed as a cyt.-P-450-Fe(III)-C6H5 complex, a new example of cytochrome P-450-Fe-metabolite complex which is stable in vivo. PMID:3779881

  5. Wastewater treatment

    SciTech Connect

    Liu, D.H.F.; Liptak, B.G. [eds.

    2000-07-01

    An exhaustive compilation, ``Wastewater Treatment'' covers subjects that run the gamut from wastewater sources, characteristics, and monitoring to chemical treatments and nutrient removal. The wealth of easy-to-use tables and illustrations provides quick and clear references, making it indispensable. Schematic drawings of equipment and devices explain the technology and techniques. With the level of detail included, one can count on finding both introductory material and very technical answers to complex questions.

  6. Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: implications for second-line therapy.

    PubMed

    Raugi, Dana N; Smith, Robert A; Ba, Selly; Toure, Macoumba; Traore, Fatou; Sall, Fatima; Pan, Charlotte; Blankenship, Lindsey; Montano, Alexandra; Olson, Julia; Dia Badiane, Ndeye Mery; Mullins, James I; Kiviat, Nancy B; Hawes, Stephen E; Sow, Papa Salif; Gottlieb, Geoffrey S

    2013-06-01

    Protease inhibitor (PI)-based antiretroviral therapy (ART) can effectively suppress HIV-2 plasma load and increase CD4 counts; however, not all PIs are equally active against HIV-2, and few data exist to support second-line therapy decisions. To identify therapeutic options for HIV-2 patients failing ART, we evaluated the frequency of PI resistance-associated amino acid changes in HIV-2 sequences from a cohort of 43 Senegalese individuals receiving unboosted indinavir (n = 18 subjects)-, lopinavir/ritonavir (n = 4)-, or indinavir and then lopinavir/ritonavir (n = 21)-containing ART. Common protease substitutions included V10I, V47A, I54M, V71I, I82F, I84V, L90M, and L99F, and most patients harbored viruses containing multiple changes. Based on genotypic data, we constructed a panel of 15 site-directed mutants of HIV-2ROD9 containing single- or multiple-treatment-associated amino acid changes in the protease-encoding region of pol. We then quantified the susceptibilities of the mutants to the HIV-2 "active" PIs saquinavir, lopinavir, and darunavir using a single-cycle assay. Relative to wild-type HIV-2, the V47A mutant was resistant to lopinavir (6.3-fold increase in the mean 50% effective concentration [EC50]), the I54M variant was resistant to darunavir and lopinavir (6.2- and 2.7-fold increases, respectively), and the L90M mutant was resistant to saquinavir (3.6-fold increase). In addition, the triple mutant that included I54M plus I84V plus L90M was resistant to all three PIs (31-, 10-, and 3.8-fold increases in the mean EC50 for darunavir, saquinavir, and lopinavir, respectively). Taken together, our data demonstrate that PI-treated HIV-2 patients frequently harbor viruses that exhibit complex patterns of PI cross-resistance. These findings suggest that sequential PI-based regimens for HIV-2 treatment may be ineffective. PMID:23571535

  7. Nonoperative, dynamic treatment of acute achilles tendon rupture: influence of early weightbearing on biomechanical properties of the plantar flexor muscle-tendon complex-a blinded, randomized, controlled trial.

    PubMed

    Barfod, Kristoffer Weisskirchner; Bencke, Jesper; Lauridsen, Hanne Bloch; Dippmann, Christian; Ebskov, Lars; Troelsen, Anders

    2015-01-01

    Acute Achilles tendon rupture alters the biomechanical properties of the plantar flexor muscle-tendon complex that can affect functional performance and the risk of repeat injury. The purpose of the present study was to compare the biomechanical properties of the plantar flexor muscle-tendon complex in patients randomized to early weightbearing or non-weightbearing in the nonoperative treatment of Achilles tendon rupture. A total of 60 patients were randomized to full weightbearing from day 1 of treatment or non-weightbearing for 6 weeks. After 6 and 12 months, the peak passive torque at 20° dorsiflexion, the stiffness during slow stretching, and the maximal strength were measured in both limbs. The stiffness of the plantar flexor muscle-tendon complex in the terminal part of dorsiflexion was significantly increased (p = .024) in the non-weightbearing group at 12 months. The peak passive torque was significantly lower for the affected limb at 6 months (91%; p = .01), and the stiffness was significantly lower for the affected limb during the early part of dorsiflexion at 6 (67%; p < .001) and 12 (77%; p < .001) months. In conclusion, an increased stiffness of the plantar flexor muscle-tendon complex in the terminal part of dorsiflexion was found in the non-weightbearing group. The altered stiffness and strength in the affected limb could affect the coordination of gait and running. PMID:25618802

  8. Use of the Boomerang catalyst advantage closure device to facilitate complex multistaged percutaneous revascularization procedures for the treatment of critical limb ischemia.

    PubMed

    Garcia, Joel A; Casserly, Ivan P

    2009-07-01

    An increasing spectrum of complex peripheral arterial disease may be successfully treated using percutaneous revascularization techniques. A pair of challenging peripheral revascularization procedures in patients with critical limb ischemia is presented, where an array of interventional tools and techniques were required, and the off-label use of the Boomerang catalyst system closure device was important in managing a variety of complex arterial access issues and ultimately allowing procedural success. PMID:19530181

  9. Reduction of viral load and immune complex load on CD4+ lymphocytes as a consequence of highly active antiretroviral treatment (HAART) in HIV-infected hemophilia patients

    Microsoft Academic Search

    Volker Daniel; Caner Süsal; Anette Melk; Rolf Weimer; Marianne Kröpelin; Rainer Zimmermann; Angela Huth-Kühne; Christian Uhle; Gerhard Opelz

    1999-01-01

    Background and Objectives: Human immunodeficiency virus (HIV)-induced immune complex load on circulating CD4+ blood lymphocytes is associated with dysfunction and depletion of CD4+ lymphocytes and with increased monocyte\\/macrophage function. It was investigated whether HAART reduces both the viral load in plasma and the number of immune complex-coated CD4+ lymphocytes in the blood, and whether CD4+ counts are associated with viral

  10. Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins—a single cohort 4-year follow-up study

    PubMed Central

    Hefter, Harald; Hartmann, Christian; Kahlen, Ulrike; Moll, Marek; Bigalke, Hans

    2012-01-01

    Objectives In long-term botulinum neurotoxin treatment, loss of therapeutic efficacy may occur due to neutralising antibody formation. Preliminary results with incobotulinumtoxinA, a preparation free of complexing/accessory proteins, have indicated a low antigenicity. We hypothesised that continuous treatment with this botulinum neurotoxin preparation would not result in an increase in neutralising antibody titres (NABTs) in patients with pre-existing NABTs. Design Prospective, blinded cohort study. Setting Single centre in Germany. Participants Thirty-seven cervical dystonia patients with NABTs and partial secondary non-responsiveness to their previous botulinum neurotoxin type A treatment. Intervention Three-monthly intramuscular injections of incobotulinumtoxinA with a constant dose of 200?MU per injection during the first year; thereafter up to 500?MU for the next 36?months. Outcome measures Primary outcome measure: number of patients in whom NABTs declined below the initial titre after 48?months of incobotulinumtoxinA treatment or in whom titres had become negative within the 48?months. Secondary outcome measure: steepness of changes in NABT. NABTs were determined by mouse hemidiaphragm assay. Findings were compared to long-term data from 24 cervical dystonia patients who had developed NABTs and in whom treatment had been discontinued. Results Following a transient increase in the first 24?months under incobotulinumtoxinA treatment in some patients, NABTs declined well below the initial titre in the majority of patients. Test assay results were negative in most of the patients followed for more than 36?months. NABTs seemed to decline into the negative detection range as rapidly under incobotulinumtoxinA treatment as after cessation of botulinum neurotoxin therapy. Conclusions The reduction of NABTs despite continuous treatment with incobotulinumtoxinA indicates low antigenicity of incobotulinumtoxinA. This might have implications on restrictions such as minimum injection intervals of ?10?weeks currently in place for maintaining successful long-term application of botulinum neurotoxin. PMID:22864418

  11. Principles of Treatment Addiction treatment must assist the individual with

    E-print Network

    Polly, David

    TREATMENT Principles of Treatment Addiction treatment must assist the individual with 1. stopping in the family, at work and in society. Guidelines of Effective Treatment Viewing addiction as a complex of using a variety of approaches in addiction treatment. Behavioral therapies such as individual and group

  12. EXAFS, XPS and electrochemical studies on oxygen reduction catalysts obtained by heat treatment of iron phenanthroline complexes supported on high surface area carbon black

    Microsoft Academic Search

    M Bron; J Radnik; M Fieber-Erdmann; P Bogdanoff; S Fiechter

    2002-01-01

    Oxygen reduction catalysts have been prepared on the basis of heat-treated, carbon supported iron phenanthroline complexes. The activity of the catalyst towards oxygen reduction depends on the surface area of the carbon used in the synthesis. It is higher than the activity of other alternative oxygen reduction catalysts based on ruthenium. Related to the amount of metal, the activity is

  13. Treatment of Patients With Complex Regional Pain Syndrome Type I With Mannitol: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Study

    Microsoft Academic Search

    Roberto S. Perez; Elien Pragt; José Geurts; Wouter W. Zuurmond; Jaap Patijn; Maarten van Kleef

    2008-01-01

    To assess the effects of intravenous administration of the free radical scavenger mannitol 10% on complaints associated with complex regional pain syndrome Type I (CRPS I), a randomized, placebo-controlled, double-blinded trial was performed. Forty-one CRPS I patients according to the Bruehl et al diagnostic criteria, were included in 2 outpatient pain clinics of 2 university medical centers and randomly assigned

  14. Ab initio treatment of the chemical reaction precursor complex Br(2P)-HCN. 2. Bound-state calculations and infrared spectra.

    PubMed

    Fishchuk, Anna V; Merritt, Jeremy M; Groenenboom, Gerrit C; Avoird, Ad van der

    2007-08-01

    Rovibronic energy levels and properties of the Br(2P)-HCN complex were obtained from three-dimensional calculations, with HCN kept linear and the CN bond frozen. All diabatic states that correlate to the 2P3/2 and 2P1/2 states of the Br atom were included and spin-orbit coupling was taken into account. The 3 x 3 matrix of diabatic potential surfaces was taken from the preceding paper (paper 1). In agreement with experiment, we found two linear isomers, Br-NCH and Br-HCN. The calculated binding energies are very similar: D0 = 352.4 cm(-1) and D0 = 349.1 cm(-1), respectively. We established, also in agreement with experiment, that the ground electronic state of Br-NCH has |Omega| = (1/2) and that Br-HCN has a ground state with |Omega| = (3/2), where the quantum number, Omega, is the projection of the total angular momentum, J, of the complex on the intermolecular axis R. This picture can be understood as being caused by the electrostatic interaction between the quadrupole of the Br(2P) atom and the dipole of HCN, combined with the very strong spin-orbit coupling in Br. We predicted the frequencies of the van der Waals modes of both isomers and found a direct Renner-Teller splitting of the bend mode in Br-HCN and a smaller, indirect, splitting in Br-NCH. The red shift of the CH stretch frequency in the complex, relative to free HCN, was calculated to be 1.98 cm(-1) for Br-NCH and 23.11 cm(-1) for Br-HCN, in good agreement with the values measured in helium nanodroplets. Finally, with the use of the same potential surfaces, we modeled the Cl(2P)-HCN complex and found that the experimentally observed linear Cl-NCH isomer is considerably more stable than the (not observed) Cl-HCN isomer. This was explained mainly as an effect of the substantially smaller spin-orbit coupling in Cl, relative to Br. PMID:17567109

  15. Land Treatment Digital Library

    USGS Publications Warehouse

    Pilliod, David S.; Welty, Justin L.

    2013-01-01

    The Land Treatment Digital Library (LTDL) was created by the U.S. Geological Survey to catalog legacy land treatment information on Bureau of Land Management lands in the western United States. The LTDL can be used by federal managers and scientists for compiling information for data-calls, producing maps, generating reports, and conducting analyses at varying spatial and temporal scales. The LTDL currently houses thousands of treatments from BLM lands across 10 states. Users can browse a map to find information on individual treatments, perform more complex queries to identify a set of treatments, and view graphs of treatment summary statistics.

  16. A psychological intervention for smoking cessation delivered as treatment for smokers with chronic obstructive pulmonary disease: Multiple needs of a complex group and recommendations for novel service development.

    PubMed

    Yap, Su Yin; Lunn, Sarah; Pang, Elizabeth; Croft, Carla; Stern, Myra

    2015-08-01

    This pilot study investigated the benefits of adjunctive psychological intervention for smokers accessing standard smoking cessation interventions. Chronic obstructive pulmonary disease (COPD) smokers attending a smoking cessation service were offered up to 12 adjunctive clinical psychology sessions. Baseline data included demographics, smoking history, and disease severity. Outcomes included attendance and quit rate. In all, 59 patients with moderate COPD were referred. Of the 20 patients who attended training sessions, 7 (35%) were relapse prevention referrals and 13 (65%) were current smokers. Of the seven relapse prevention referrals, six (86%) maintained their quit, 2 of 13 (15%) of the current smoker group maintained a 28-day quit and 3 of 13 (23%) of current smokers reduced their tobacco intake. For COPD smokers with a heavy smoking history and multiple past quit attempts, there was insufficient evidence to show that additional psychological intervention leads to higher quit rates. Significant barriers to quitting and complex medical and psychosocial needs were identified in this group, suggesting that the current 'one-size-fits-all' approach to smoking cessation may not be sufficient to meet the needs of such a complex group. PMID:25990130

  17. An effective pre-treatment method for the determination of short-chain fatty acids in a complex matrix by derivatization coupled with headspace single-drop microextraction.

    PubMed

    Chen, Yuan; Li, Yun; Xiong, Yongqiang; Fang, Chenchen; Wang, Xiaotao

    2014-01-17

    We have developed a sample preparation method involving derivatization combined with headspace single-drop microextraction (HS-SDME) for the determination of short-chain fatty acids (SCFAs) in complex matrices. The derivatization of SCFAs was conducted using the BF3/ethanol method prior to HS-SDME. The HS-SDME extraction conditions for the derivatization products (ethyl esters) of SCFAs were optimized using 1.0?L of dibutylphthalate (DBP), 1000rpm stirring speed, 30% (w/v) NaCl, 20min extraction time, and 7mL of sample solution in a 12mL vial. Quantitative determination of ethyl esters was performed using gas chromatography (GC). Linear calibration curves and excellent reproducibility were obtained using these optimized extraction conditions. Compared with our previous work, the significantly lower detection limits (0.11, 0.017, 0.0060, and 0.0024?g/mL for C2 to C5 SCFAs, respectively) indicate that this new method is suitable for quantitative analysis of SCFAs in complex matrices, such as the RuO4 oxidation products of kerogen or asphaltene. PMID:24388413

  18. The complex role of personality in cancer treatment: impact of dependency-detachment on health status, distress, and physician-patient relationship.

    PubMed

    Porcerelli, John H; Bornstein, Robert F; Porcerelli, Daniel; Arterbery, V Elayne

    2015-04-01

    Personality traits have been associated with positive and negative adjustment to a cancer diagnosis. No studies have assessed trait dependency and detachment and their relationship to health, distress, and the doctor-patient relationship in patients undergoing radiation treatment for cancer. Fifty adults (32 women; mean [SD], 60.32 [12.74] years) undergoing radiation treatment for a variety of cancers completed measures of dependency and detachment, doctor-patient relationship, physical health, somatization, anxiety, and depression. Overdependence scores were positively and significantly correlated with patients' anxiety and negatively and significantly correlated with the physician-patient relationship. Detachment scores were positively and significantly correlated with pain, somatization, depression, and anxiety and marginally associated with lower health-related quality of life. These preliminary findings support the construct validity and clinical utility of trait dependency and detachment testing with oncology patients and suggest that detachment is associated with poorer quality of life and higher psychological distress, whereas dependency is associated with poorer doctor-patient relationships after a cancer diagnosis. PMID:25756708

  19. Packaged Waste Treatment

    NASA Technical Reports Server (NTRS)

    1977-01-01

    This Jacksonville, Florida, apartment complex has a wastewater treatment system which clears the water, removes harmful microorganisms and reduces solid residue to ash. It is a spinoff from spacecraft waste management and environmental control technology.

  20. Neurotoxicity, haemostatic disturbances and haemolytic anaemia after a bite by a Tunisian saw-scaled or carpet viper (Echis 'pyramidum'-complex): failure of antivenom treatment.

    PubMed

    Gillissen, A; Theakston, R D; Barth, J; May, B; Krieg, M; Warrell, D A

    1994-08-01

    A young man in Germany was bitten by a large captive saw-scaled viper (Echis 'pyramidum'-complex) of Tunisian origin. During the first few hours after the bite he developed evidence of disseminated intravascular coagulation and fibrinolysis, and bled spontaneously. Despite being given a total of 310 ml of three different Echis-specific antivenoms (together with large amounts of fresh frozen plasma and concentrated clotting factors), venom antigenaemia (measured by enzyme immunoassay) and coagulopathy persisted for more than 10 days, and he developed a haemolytic anaemia and mild renal dysfunction. Transient bilateral ptosis was attributed to envenoming. The venom of the snake responsible for the bite was immunologically distinct from that of Nigerian E. ocellatus and was clearly not neutralised by the three monospecific antivenoms which had been administered. This case is another illustration of the geographical variation in snake venoms and the need for pooling venoms from snakes from different parts of the geographical range in the preparation of antivenoms. Envenoming by North African Echis species may not be reversible by available antivenoms. PMID:7985198

  1. Toward a 3D Cellular Model for Studying In Vitro the Outcome of Photodynamic Treatments: Accounting for the Effects of Tissue Complexity

    PubMed Central

    Alemany-Ribes, Mireia; García-Díaz, María; Busom, Marta; Nonell, Santi

    2013-01-01

    Clinical therapies have traditionally been developed using two-dimensional (2D) cell culture systems, which fail to accurately capture tissue complexity. Therefore, three-dimensional (3D) cell cultures are more attractive platforms to integrate multiple cues that arise from the extracellular matrix and cells, closer to an in vivo scenario. Here we report the development of a 3D cellular model for the in vitro assessment of the outcome of oxygen- and drug-dependent therapies, exemplified by photodynamic therapy (PDT). Using a synthetic self-assembling peptide as a cellular scaffold (RAD16-I), we were able to recreate the in vivo limitation of oxygen and drug diffusion and its biological effect, which is the development of cellular resistance to therapy. For the first time, the production and decay of the cytotoxic species singlet oxygen could be observed in a 3D cell culture. Results revealed that the intrinsic mechanism of action is maintained in both systems and, hence, the dynamic mass transfer effects accounted for the major differences in efficacy between the 2D and 3D models. We propose that this methodological approach will help to improve the efficacy of future oxygen- and drug-dependent therapies such as PDT. PMID:23442191

  2. [Clinical guidelines as part of total quality management. Analysis of heterogenous treatment concepts of sepsis in various clinics with computer assisted generation, logical testing and complexity assessment of clinical algorithms].

    PubMed

    Sitter, H; Dietz, W; Stinner, B; Geks, J; Bauhofer, A; Celik, I; Prünte, H; Lorenz, W

    1999-01-01

    Generation, local tailoring, implementation and evaluation of clinical guidelines is an integral part of quality management. Clinical guidelines are intimately related to the independency of physicians' decisions. By this the physicians should be responsible for guideline development and guarantee the use of adequate methods of total quality management and outcome assessment. Formal consensus finding and transparency of evidence are necessary to guarantee the use of guidelines. Clinical algorithms are highly formalized and they are well suited for generation and analysis by the software ALGO. Determination of complexity and comparison of the clinical contents of algorithms is done by the scores CASA (Clinical Algorithm Structural Analysis) and CAPA (Clinical Algorithm Patient Abstraction). In a study of 22 clinical departments on treatment management concepts in sepsis following anastomotic insufFiciency in colorectal carcinoma a considerable heterogeneity was shown using this program. PMID:10355087

  3. Anti-N-methyl-d-aspartate receptor encephalitis in a patient with a 7-year history of being diagnosed as schizophrenia: complexities in diagnosis and treatment

    PubMed Central

    Huang, Chaohua; Kang, Yukun; Zhang, Bo; Li, Bin; Qiu, Changjian; Liu, Shanming; Ren, Hongyan; Yang, Yanchun; Liu, Xiehe; Li, Tao; Guo, Wanjun

    2015-01-01

    Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a form of autoimmune encephalitis associated with antibodies against the NR1 subunits of NMDARs. Although new-onset acute prominent psychotic syndromes in patients with NMDAR encephalitis have been well documented, there is a lack of case studies on differential diagnosis and treatment of anti-NMDAR encephalitis after a long-term diagnostic history of functional psychotic disorders. The present study reports an unusual case of anti-NMDAR encephalitis. The patient had been diagnosed with schizophrenia 7 years earlier, and was currently hospitalized for acute-onset psychiatric symptoms. The diagnosis became unclear when the initial psychosis was confounded with considerations of other neurotoxicities (such as neuroleptic malignant syndrome). Finally, identification of specific immunoglobulin G NR1 autoantibodies in the cerebrospinal fluid and greater effectiveness of immunotherapy over antipsychotics alone (which has been well documented in anti-NMDAR encephalitis) indicated the diagnosis of anti-NMDAR encephalitis in this case. Based on the available evidence, however, the relationship between the newly diagnosed anti-NMDAR encephalitis and the seemingly clear, long-term history of schizophrenia in the preceding 7 years is uncertain. This case report illustrates that psychiatrists should consider anti-NMDAR encephalitis and order tests for specific immunoglobulin G NR1 autoantibodies in patients presenting with disorientation, disturbance of consciousness, cognitive deficit, dyskinesia, autonomic disturbance, or rapid deterioration, even with a seemingly clear history of a psychiatric disorder and no specific findings on routine neuroimaging, electroencephalography, or cerebrospinal fluid tests in the early stage of the illness.

  4. A Phase I Trial of Samarium-153-Lexidronam Complex for Treatment of Clinically Nonmetastatic High-Risk Prostate Cancer: First Report of a Completed Study

    SciTech Connect

    Valicenti, Richard K., E-mail: richard.valicenti@ucdmc.ucdavis.ed [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Trabulsi, Edouard [Department of Urology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Intenzo, Charles [Department of Radiology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States); Lavarino, Jorosali [Department Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Xu Yihuan; Chervoneva, Inna [Department of Pharmacology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA (United States)

    2011-03-01

    Purpose: We completed a Phase I trial to determine the maximum tolerated dose of samarium-153 EDTMP ({sup 153}Sm) with hormonal therapy (HT) and radiation therapy (RT) in high-risk clinically nonmetastatic prostate cancer. Methods and Materials: High-risk M0 prostate cancer patients (prostate-specific antigen >20 ng/mL, Gleason score >7, or >T3) were eligible for this prospective trial of dose-escalated radioactive {sup 153}Sm-EDTMP (.25-2.0 mCi/kg) as primary or postoperative therapy. After 1 month of HT, we administered {sup 153}Sm-EDTMP followed by 4 more months of HT, 46.8 Gy to the pelvic region and 23.4 Gy to the prostate target (TD = 70.2 Gy). The primary endpoint was Grade III toxicity or higher by the National Cancer Institute Common Toxicity Criteria. Results: Twenty-nine patients enrolled (median prostate-specific antigen = 8.2 ng/mL, 27/29 (93%) T stage {>=}T2b, 24/29 (83%) had Gleason >7) and received {sup 153}Sm-EDTMP (.25 mCi/kg, 4 patients; 0.5 mCi/kg, 4 patients; 0.75 mCi/kg, 6 patients; 1.0 mCi/kg, 6 patients; 1.5 mCi/kg, 5 patients; 2.0mCi/kg, 4 patients). Twenty-eight patients underwent all planned therapy without delays (1 patient required surgery before the start of RT). With a median follow-up time of 23 months, there were 2 patients (7 %) experiencing Grade III hematologic toxicity. There were no other Grade III or IV side effects. Conclusions: Our trial demonstrates that 2 mCi/kg {sup 153}Sm -EDTMP with HT and RT was safe and feasible in men with high-risk M0 prostate cancer. A Phase II study to test this treatment is currently underway by the Radiation Therapy Oncology Group.

  5. Carney Complex

    MedlinePLUS

    ... Ephelides (freckles) LAMB syndrome – Lentigines, Atrial Myxoma, and Blue nevi What causes Carney complex? Carney complex is ... melanotic schwannoma, meaning tumors that grow on nerves Blue nevi, which are blue-black moles Osteochondromyxoma (bone ...

  6. Cultural Complexity

    Microsoft Academic Search

    Wolfgang Fikentscher

    1998-01-01

    This paper is divided into four parts. The first section (I.) consists of definitions which center on the concept of complexity. As a minimum, the terms, system, complexity, and adaptation as used in this paper need an explanation. The second section (II.) is a sketch of cultural complexity in the real world. I will use Pueblo tribal laws and other

  7. Complexity and Catalytic Efficiency of Hepatitis C Virus (HCV) NS3 and NS4A Protease Quasispecies Influence Responsiveness to Treatment with Pegylated Interferon plus Ribavirin in HCV/HIV-Coinfected Patients?†

    PubMed Central

    Aparicio, Ester; Franco, Sandra; Parera, Mariona; Andrés, Cristina; Tural, Cristina; Clotet, Bonaventura; Martínez, Miguel Angel

    2011-01-01

    The role of the hepatitis C virus (HCV) NS3/4A protease in ablating the signaling pathway involved in the production of alpha/beta interferon (IFN-?/?) suggests a relationship between NS3/4A proteolytic activity and a patient's response to IFN-based therapy. To identify viral factors associated with the HCV treatment response, we analyzed the pretreatment NS3/4A protease gene quasispecies composition of 56 HCV genotype 1–HIV-1-coinfected patients treated in our clinic with pegylated IFN (pegIFN) plus ribavirin (RBV). The catalytic efficiency of the dominant (i.e., the most abundant) quasispecies was also assayed for Cardif cleavage and correlated with treatment outcome. A total of 1,745 clones were isolated and sequenced. Significantly less nucleotide quasispecies heterogeneity and lower Shannon entropy values were detected within the responder group (P < 0.05). A correlation was also found between the efficiency of NS3/4A protease Cardif cleavage and therapy outcome. Proteases from sustained responder patients were more efficient at processing Cardif (mean ± standard error of the mean [SEM], 0.8960 ± 0.05568; n = 19) than proteases from nonresponders (mean ± SEM, 0.7269 ± 0.05306; n = 37; P < 0.05). Finally, the amino acid p distance (the proportion [p] of nucleotide sites at which two sequences being compared are different) was significantly shorter in patients with an interleukin-28B (IL-28B) risk allele (P < 0.01), suggesting that IL-28B risk allele carriers exert a lower positive selection pressure on the NS3/4A protease. NS3/4A protease efficiency in cleaving Cardif may be associated with the pegIFN-RBV treatment response, as shown in our cohort of HIV-HCV-coinfected patients. Greater NS3/4A nucleotide heterogeneity and higher Shannon entropy values in nonresponders suggest that less HCV quasispecies complexity may favor a better response to pegIFN-RBV. PMID:21471227

  8. Hyperbaric treatment

    NASA Technical Reports Server (NTRS)

    Amoroso, Michael T.

    1990-01-01

    Viewgraphs on hyperbaric treatment are presented. Topics covered include: hyperbaric treatment - purpose; decompression sickness; sources of decompression sickness; physical description; forms of decompression sickness; hyperbaric treatment of decompression sickness; and duration of treatment.

  9. Complexe oplossingen

    Microsoft Academic Search

    Margot Scholte

    2010-01-01

    Samenvatting  Ik ben al enige tijd gefascineerd door ‘complexe oplossingen’. Complexe oplossingen zijn oplossingen die qua complexiteit\\u000a niet in verhouding staan tot het ervaren probleem. Denk aan de paarse krokodil: je ziet je verloren opblaasbeest achter glas,\\u000a maar je mag hem niet meenemen, voordat je aan alle procedures hebt voldaan.

  10. Complex derivatives

    NASA Astrophysics Data System (ADS)

    Battiston, Stefano; Caldarelli, Guido; Georg, Co-Pierre; May, Robert; Stiglitz, Joseph

    2013-03-01

    The intrinsic complexity of the financial derivatives market has emerged as both an incentive to engage in it, and a key source of its inherent instability. Regulators now faced with the challenge of taming this beast may find inspiration in the budding science of complex systems.

  11. Designing Complexity

    ERIC Educational Resources Information Center

    Glanville, Ranulph

    2007-01-01

    This article considers the nature of complexity and design, as well as relationships between the two, and suggests that design may have much potential as an approach to improving human performance in situations seen as complex. It is developed against two backgrounds. The first is a world view that derives from second order cybernetics and radical…

  12. Dorsal capsuloplasty for dorsal instability of the distal ulna.

    PubMed

    Kouwenhoven, S T P; de Jong, T; Koch, A R

    2013-05-01

    Background?Dorsal instability of the distal ulna can lead to chronic wrist pain and loss of function. Structural changes to the dorsal radioulnar ligaments (DRUL) of the triangular fibrocartilage complex (TFCC) and the dorsal capsule around the ulnar head with or without foveal detachment can lead to volar subluxation of the distal radius e.g., dorsal instability of the distal ulna. Purpose?Is to evaluate the post-operative results of reinstituting distal radioulnar joint (DRUJ) stability through reefing of the dorsal capsule and dorsal radioulnar ligaments, with and without a foveal reattachment of the TFCC. Methods?A total of 37 patients were included in this retrospective study. Diagnosis and treatment was based strictly on dry wrist arthroscopy. In 17 patients isolated reefing of the DRUL and their collateral tissue extension was performed. In 20 patients an additional foveal reinsertion was performed. Postoperative results were evaluated with the DASH questionnaire, VAS scores, grip strength and range of motion. These findings were extrapolated in the Mayo wrist score. The two subgroups were compared. Results?Mayo wrist scores of the whole population had a mean of 73. There was no difference between the group that was treated with reefing of the DRUL only and the group that was treated with a combined foveal reinsertion. Conclusion?This relatively simple 'dorsal reefing' procedure, with foveal reinsertion when indicated, is a reliable method to restore volar-dorsal DRUJ stability with a significant decrease in pain sensation, good DASH scores and restoration of functional grip strength and ROM. Type of Study/Level of Evidence?Therapeutic, Level IV. PMID:24436811

  13. Dorsal Capsuloplasty for Dorsal Instability of the Distal Ulna

    PubMed Central

    Kouwenhoven, S.T.P.; de Jong, T.; Koch, A.R.

    2013-01-01

    Background?Dorsal instability of the distal ulna can lead to chronic wrist pain and loss of function. Structural changes to the dorsal radioulnar ligaments (DRUL) of the triangular fibrocartilage complex (TFCC) and the dorsal capsule around the ulnar head with or without foveal detachment can lead to volar subluxation of the distal radius e.g., dorsal instability of the distal ulna. Purpose?Is to evaluate the post-operative results of reinstituting distal radioulnar joint (DRUJ) stability through reefing of the dorsal capsule and dorsal radioulnar ligaments, with and without a foveal reattachment of the TFCC. Methods?A total of 37 patients were included in this retrospective study. Diagnosis and treatment was based strictly on dry wrist arthroscopy. In 17 patients isolated reefing of the DRUL and their collateral tissue extension was performed. In 20 patients an additional foveal reinsertion was performed. Postoperative results were evaluated with the DASH questionnaire, VAS scores, grip strength and range of motion. These findings were extrapolated in the Mayo wrist score. The two subgroups were compared. Results?Mayo wrist scores of the whole population had a mean of 73. There was no difference between the group that was treated with reefing of the DRUL only and the group that was treated with a combined foveal reinsertion. Conclusion?This relatively simple 'dorsal reefing' procedure, with foveal reinsertion when indicated, is a reliable method to restore volar-dorsal DRUJ stability with a significant decrease in pain sensation, good DASH scores and restoration of functional grip strength and ROM. Type of Study/Level of Evidence?Therapeutic, Level IV. PMID:24436811

  14. Feline respiratory disease complex.

    PubMed

    Cohn, Leah A

    2011-11-01

    Feline respiratory disease complex (FRDC) refers to the characteristic acute presentation of a contagious respiratory or ocular disease caused by one or multiple pathogens. Environmental and host factors impact the transmission, clinical presentation, preventive strategy, and treatment of affected cats. The FRDC is especially problematic in settings where large numbers of cats cohabit, including animal shelters, catteries, and semi-feral colonies. Although elimination of FRDC is an unrealistic goal, improved understanding can lead to strategies to minimize disease impact. PMID:22041216

  15. HIFU: Local Treatment of Prostate Cancer

    Microsoft Academic Search

    H. Azzouz; J. J. M. C. H. de la Rosette

    2006-01-01

    ObjectiveTreatment of carcinoma of the prostate (CaP) begs some complex questions. Different disease stages call for different treatment modalities and no universally ‘gold standard’ treatment has yet been agreed upon. In the present work we will present the results, indications and limitations of HIFU in the treatment of CaP.

  16. Treatment of Mitochondrial Disorders

    PubMed Central

    Avula, Sreenivas; Parikh, Sumit; Demarest, Scott; Kurz, Jonathan; Gropman, Andrea

    2014-01-01

    Opinion statement While numerous treatments for mitochondrial disorders have been suggested, relatively few have undergone controlled clinical trials. Treatment of these disorders is challenging, as only symptomatic therapy is available. In this review we will focus on newer drugs and treatment trials in mitochondrial diseases, with a special focus on medications to avoid in treating epilepsy and ICU patient with mitochondrial disease, which has not been included in such a review. Readers are also referred to the opinion statement in A Modern Approach to the Treatment of Mitochondrial Disease published in Current Treatment Options in Neurology 2009. Many of the supplements used for treatment were reviewed in the previous abstract, and dosing guidelines were provided. The focus of this review is on items not previously covered in depth, and our discussion includes more recently studied compounds as well as any relevant updates on older compounds. We review a variety of vitamins and xenobiotics, including dichloroacetate (DCA), arginine, coenzyme Q10, idebenone, EPI-743, and exercise training. Treatment of epilepsy, which is a common feature in many mitochondrial phenotypes, warrants special consideration due to the added toxicity of certain medications, and we provide a discussion of these unique treatment challenges. Interesting, however, with only a few exceptions, the treatment strategies for epilepsy in mitochondrial cytopathies are the same as for epilepsy without mitochondrial dysfunction. We also discuss intensive care management, building upon similar reviews, adding new dimensions, and demonstrating the complexity of overall care of these patients. PMID:24700433

  17. Radiographic and Arthroscopic Assessment of DRUJ Instability Due to Foveal Avulsion of the Radioulnar Ligament in Distal Radius Fractures.

    PubMed

    Nakamura, Toshiyasu; Iwamoto, Takuji; Matsumura, Noboru; Sato, Kazuki; Toyama, Yoshiaki

    2014-02-01

    Background?As the triangular fibrocartilage complex (TFCC) anchors the distal radius to the ulna via the radioulnar ligament (RUL), a severely displaced distal fragment of the radius may be associated with a foveal avulsion of the TFCC. The purpose of this retrospective study was to assess, radiographically and arthroscopically, the relationship between displacement of the radius, the ulnar styloid, and avulsion of the RUL resulting in distal radioulnar joint (DRUJ) instability. Materials and Methods?Twenty-nine wrists of 29 patients with intra- and extra-articular distal radius fractures/malunion who underwent reduction or a corrective osteotomy of the displaced/malunited fracture, and/or wrist arthroscopy, were assessed radiographically and arthroscopically. Radial translation, radial inclination, radial shortening, volar or dorsal tilt, and the presence of an ulnar styloid fracture with more than 4?mm of displacement were measured from the initial films. Radiocarpal arthroscopy was used to assess peripheral lesions of the TFCC, while DRUJ arthroscopy was used to assess the foveal attachment. The relationship between displacement of the distal radius or the ulnar styloid fracture and the TFCC injury, including avulsion of the RUL, was recorded. Results?Univariate analysis revealed that increased radial translation, decreased radial inclination, increased radial shortening, and an ulnar styloid fragment radially displaced by more than 4?mm were significant predictors of RUL avulsion at the fovea. Volar or dorsal tilt of the radius and ulnar variance did not correlate with RUL avulsion or TFCC injuries. Multiple logistic regression analysis revealed that radial translation was an independent risk factor of foveal avulsion of the RUL. Conclusions?Increased radial translation and radial shortening and decreased radial inclination of the distal fragment can be associated with a foveal avulsion of the RUL. Radial translation can be an independent risk factor of foveal avulsion of the RUL. PMID:24533240

  18. Radiographic and Arthroscopic Assessment of DRUJ Instability Due to Foveal Avulsion of the Radioulnar Ligament in Distal Radius Fractures

    PubMed Central

    Nakamura, Toshiyasu; Iwamoto, Takuji; Matsumura, Noboru; Sato, Kazuki; Toyama, Yoshiaki

    2014-01-01

    Background?As the triangular fibrocartilage complex (TFCC) anchors the distal radius to the ulna via the radioulnar ligament (RUL), a severely displaced distal fragment of the radius may be associated with a foveal avulsion of the TFCC. The purpose of this retrospective study was to assess, radiographically and arthroscopically, the relationship between displacement of the radius, the ulnar styloid, and avulsion of the RUL resulting in distal radioulnar joint (DRUJ) instability. Materials and Methods?Twenty-nine wrists of 29 patients with intra- and extra-articular distal radius fractures/malunion who underwent reduction or a corrective osteotomy of the displaced/malunited fracture, and/or wrist arthroscopy, were assessed radiographically and arthroscopically. Radial translation, radial inclination, radial shortening, volar or dorsal tilt, and the presence of an ulnar styloid fracture with more than 4?mm of displacement were measured from the initial films. Radiocarpal arthroscopy was used to assess peripheral lesions of the TFCC, while DRUJ arthroscopy was used to assess the foveal attachment. The relationship between displacement of the distal radius or the ulnar styloid fracture and the TFCC injury, including avulsion of the RUL, was recorded. Results?Univariate analysis revealed that increased radial translation, decreased radial inclination, increased radial shortening, and an ulnar styloid fragment radially displaced by more than 4?mm were significant predictors of RUL avulsion at the fovea. Volar or dorsal tilt of the radius and ulnar variance did not correlate with RUL avulsion or TFCC injuries. Multiple logistic regression analysis revealed that radial translation was an independent risk factor of foveal avulsion of the RUL. Conclusions?Increased radial translation and radial shortening and decreased radial inclination of the distal fragment can be associated with a foveal avulsion of the RUL. Radial translation can be an independent risk factor of foveal avulsion of the RUL. PMID:24533240

  19. fimbriata complex

    Microsoft Academic Search

    Jason A. Johnson; Thomas C. Harrington; C. J. B. Engelbrecht

    Ceratocystis fimbriata is a widely distributed, plant pathogenic fungus that causes wilts and cankers on many woody hosts. Earlier phylogenetic analyses of DNA sequences revealed three geographic clades within the C. fimbriata complex that are centered respectively in North America, Latin America and Asia. This study looked for cryptic species within the North American clade. The internal transcribed spacer regions

  20. Researching Complexity.

    ERIC Educational Resources Information Center

    Sumara, Dennis J.

    2000-01-01

    Discusses what Complexity Theory (presented as a rubric that collects theoretical understandings from a number of domains such as ecology, biology, neurology, and education) suggests about mind, selfhood, intelligence, and practices of reading, and the import of these reconceptualizations to reader-response researchers. Concludes that developing…

  1. Palindrome complexity

    Microsoft Academic Search

    Jean-paul Allouche; Michael Baake; Julien Cassaigne; David Damanik

    2003-01-01

    We study the palindrome complexity of infinite sequences on finite alphabets, i.e., the number of palindromic factors (blocks) of given length occurring in a given se- quence. We survey the known results and obtain new results for some sequences, in particular for Rote sequences and for fixed points of primitive morphisms of constant length belonging to \\

  2. COMPLEX NUMBERS 1. Definition of complex numbers

    E-print Network

    La Rosa, Andres H.

    COMPLEX NUMBERS 1. Definition of complex numbers Complex conjugate, Magnitude Operations Addition, multiplication, reciprocal number 2. Representation of complex numbers in polar complex variable #12;2.2.A Complex numbers #12;#12;3 #12;4 #12;In short, Anytime we write Ae j we

  3. [Treatment of fistulizing Crohn's disease].

    PubMed

    Tonki?, Ante; Borzan, Vladimir

    2013-04-01

    The treatment of fistulating Crohn's disease should include a combined medical and surgical approach and should be defined on an individual basis. Asymptomatic enteroenteric fistulas usually require no treatment, but internal fistulas (gastrocolic, duodenocolic, enterovesical) that cause severe or persistent symptoms require surgical intervention. While low asymptomatic anal-introital fistula may not need surgical treatment, in case of a symptomatic enterovaginal fistula surgery is usually required. There are no controlled-randomized trials to assess the effect of medical treatment for non-perianal fistulating Crohn's disease. The incidence of perianal fistulae varies according to the location of the disease, with its occurrence varying between 21-23%. The diagnostic approach should include an examination under anesthesia, endoscopy, and either MRI or EUS before the treatment begins. Asymptomatic simple perianal fistulas require no treatment. The presence of a perianal abscess should be ascertained and if present should be drained urgently. In case of a complex perianal disease, seton placement should also be recommended. Antibiotics (metronidazole and ciprofloxacine) are useful for treating complex perianal disease, however, when discontinued, most of the fistulas relapse. The current consensus suggests that azathioprine/6-mercaptopurine is the first line medical therapy for complex perianal disease, which is always given in combination with surgical therapy (seton, fistulotomy/fistulectomy). Anti TNF-alpha agents (infliximab and adalimumab) should be used as a second choice medical treatment. In refractory and extensive complex perianal disease a diverting stoma or proctectomy should be performed. PMID:24471302

  4. Complexed iron removal from groundwater

    SciTech Connect

    Munter, R.; Ojaste, H.; Sutt, J. [Tallinn Technical University, Tallinn (Estonia). Dept. of Environmental & Chemical Technology

    2005-07-01

    The paper demonstrates an intensive work carried out and results obtained on the pilot plant of the City of Kogalym Water Treatment Station (Tjumen, Siberia, Russian Federation) to elaborate on a contemporary nonreagent treatment technology for the local iron-rich groundwater. Several filter materials (Birm, Pyrolox, hydroanthracite, Everzit, granulated activated carbon) and chemical oxidants (ozone, chlorine, hydrogen peroxide, oxygen, and potassium permanganate) were tested to solve the problem with complexed iron removal from groundwater. The final elaborated technology consists of raw water intensive aeration in the gas-degas treatment unit followed by sequential filtration through hydroanthracite and the special anthracite Everzit.

  5. Complex posterior urethral injury

    PubMed Central

    Kulkarni, Sanjay B.; Joshi, Pankaj M.; Hunter, Craig; Surana, Sandesh; Shahrour, Walid; Alhajeri, Faisal

    2015-01-01

    Objective To assess treatment strategies for seven different scenarios for treating complex pelvic fracture urethral injury (PFUI), categorised as repeat surgery for PFUI, ischaemic bulbar urethral necrosis (BUN), repair in boys and girls aged ?12 years, in patients with a recto-urethral fistula, or bladder neck incontinence, or with a double block at the bulbomembranous urethra and bladder neck/prostate region. Patients and methods We retrospectively reviewed the success rates and surgical procedures of these seven complex scenarios in the repair of PFUI at our institution from 2000 to 2013. Results In all, >550 PFUI procedures were performed at our centre, and 308 of these patients were classified as having a complex PFUI, with 225 patients available for follow-up. The overall success rates were 81% and 77% for primary and repeat procedures respectively. The overall success rate of those with BUN was 76%, using various methods of novel surgical techniques. Boys aged ?12 years with PFUI required a transpubic/abdominal approach 31% of the time, compared to 9% in adults. Young girls with PFUI also required a transpubic/abdominal urethroplasty, with a success rate of 66%. In patients with a recto-urethral fistula the success rate was 90% with attention to proper surgical principles, including a three-stage procedure and appropriate interposition. The treatment of bladder neck incontinence associated with the tear-drop deformity gave a continence rate of 66%. Children with a double block at the bulbomembranous urethra and at the bladder neck-prostate junction were all continent after a one-stage transpubic/abdominal procedure. Conclusion An understanding of complex pelvic fractures and their appropriate management can provide successful outcomes. PMID:26019978

  6. Leishmaniasis Treatment

    MedlinePLUS

    ... message, please visit this page: About CDC.gov . Parasites - Leishmaniasis Parasites Home Share Compartir Treatment Before considering treatment, the ... applies to some (not all) types of the parasite found in parts of Latin America: certain types ...

  7. Managing Complexity

    SciTech Connect

    Chassin, David P.; Posse, Christian; Malard, Joel M.

    2004-08-01

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today’s most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically-based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This paper explores the state of the art in the use physical analogs for understanding the behavior of some econophysical systems and to deriving stable and robust control strategies for them. In particular we review and discussion applications of some analytic methods based on the thermodynamic metaphor according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood.

  8. Water Treatment

    NSDL National Science Digital Library

    2013-12-18

    Water treatment on a large scale enables the supply of clean drinking water to communities. In this activity, learners develop methods to clean a polluted water sample, describe components of a water treatment process, and learn how humans impact Earth's freshwater supply. The activity simulates methods used in real water treatment including aeration, coagulation, sedimentation, filtration and disinfection. This activity would be an excellent adjunct to a guided tour of a local water treatment plant.

  9. Bimetallic complexes

    Microsoft Academic Search

    Wolfdieter A. Schenk; Thomas Gutmann

    1998-01-01

    The synthesis and reactions of bimetallic Zr(II)–Mo(0) complexes with bridging C5H4PPh2 ligands (henceforth abbreviated as Cp?) are described. Reaction of Cp2?ZrCl2 (1) with n-butyllithium in THF produces a metastable material tentatively formulated as Cp2?Zr·2 LiCl·4 THF (2). Diphenyldisulfide instantaneously converts 2 into the Zr(IV) dithiolate Cp2?Zr(SPh)2 (3). When 2 is treated with [Mo(CO)4(norbornadiene)], an unstable intermediate is formed which can

  10. PROCESS SIMULATOR FOR WASTEWATER TREATMENT PLANT

    Microsoft Academic Search

    Rimvydas Simutis

    Dynamic models and process simulators can be very useful in creation of effective control systems for wastewater treatment processes. They also allow seizing procedures of designing of technological processes, helping to estimate and to pick up successfully technological parameters, which influence stability and efficiency of processes. Modern wastewater treatment is a quite complex process, which includes several treatment steps before

  11. 3. Complex Numbers 17 3 Complex Numbers

    E-print Network

    Givental, Alexander

    3. Complex Numbers 17 3 Complex Numbers Law and Order Life is unfair: The quadratic equation x2 - 1 solutions to the equation. This is how complex numbers could have been invented. More formally, complex numbers a and b are called respectively the real part and imagi- nary part of the complex number z

  12. Psychodynamic treatment of depression.

    PubMed

    Luyten, Patrick; Blatt, Sidney J

    2012-03-01

    Findings reviewed in this article show that PT should be included in treatment guidelines for depression. BPT in particular has been found to be superior to control conditions, equally effective as other active psychological treatments, with treatment effects that are often maintained in the long run, conferring resistance to relapse. Moreover, BPT is as effective as pharmacotherapy in the acute treatment of mild to moderate depression, and, either as monotherapy or combined with medication, BPT is associated with better long-term outcome compared with pharmacotherapy alone. PT is accepted by many depressed patients as a viable and preferred treatment. Furthermore, LTPT and PA have shown promise in treating patients with complex psychological disorders characterized by mood problems, often with comorbid personality problems. Finally, although studies suggest that effects of PT may be achieved somewhat slower compared with other forms of psychotherapy as well as medication in the acute treatment of depression, LTPT appears to be more clinically effective and perhaps more cost effective in the long run, particularly for chronically depressed patients. As noted, these conclusions need to be interpreted within the context of important limitations. Compared with other treatments, the evidence base for PT in depression remains relatively small, despite a respectable research tradition supporting psychodynamic assumptions with regard to the causation of depression. Moreover, and perhaps most importantly, although more studies now include longer follow-up assessments, our knowledge about the long-term effects of so-called evidence-based treatments of depression remains sketchy at best. In this context, the growing evidence for the efficacy and effectiveness of LTPT is promising. Overall, it is clear that the future of the treatment of depression may lie in a combined disorder- and person-centered, tailored-made approach, which takes into account, particularly in chronic depression, the broader interpersonal context and life history of the individual. It is clear that psychodynamic therapies have an important role to play in this respect. PMID:22370494

  13. Neural Networks and Dynamic Complex Systems

    Microsoft Academic Search

    Geoffrey Fox; W. Funnanski; Alex Ho; Jeff Koller; Petar Simic; Isaac Wong

    1989-01-01

    We describe the use of neural networks for optimization and inference associated with a variety of complex systems. We show how a string formalism can be used for parallel computer decomposition, message routing and sequential optimizing compilers. We extend these ideas to a general treatment of spatial assessment and distributed artificial intelligence. 1: Introduction We study a variety of complex

  14. [Principles of wound treatment].

    PubMed

    Bruhin, A; Metzger, J

    2007-09-01

    New techniques and devices have revolutionized the treatment of wounds during the last years. For the treatment of wounds we have nowadays a great variety of new gadgets, tools and methods. Complex wounds require specific skills, given the fact that a great number of different promising methods are on the market to enable an optimal wound management. Well educated "wound experts" are required to overcome the problems of very complicated and chronic wound problems. The importance of an interdisciplinary team increases while facing the problems of special wound disorders such as a diabetic food, food ulcers or the problems of open abdomen in case of severe peritonitis. In this overview the main principles of modern wound treatment are outlined. The aim of this article is to present a good summary of wound judgement and treatment for the practioner. Increasingly important is it to point out the situation of complexe wounds which should be judgded and treated with the help of a "wound expert". PMID:18075140

  15. SCFA lead lab technical assistance at Oak Ridge Y-12 nationalsecurity complex: Evaluation of treatment and characterizationalternatives of mixed waste soil and debris at disposal area remedialaction DARA solids storage facility (SSF)

    SciTech Connect

    Hazen, Terry

    2002-08-26

    On July 17-18, 2002, a technical assistance team from the U.S. Department of Energy (DOE) Subsurface Contaminants Focus Area (SCFA) met with the Bechtel Jacobs Company Disposal Area Remedial Action (DARA) environmental project leader to review treatment and characterization options for the baseline for the DARA Solids Storage Facility (SSF). The technical assistance request sought suggestions from SCFA's team of technical experts with experience and expertise in soil treatment and characterization to identify and evaluate (1) alternative treatment technologies for DARA soils and debris, and (2) options for analysis of organic constituents in soil with matrix interference. Based on the recommendations, the site may also require assistance in identifying and evaluating appropriate commercial vendors.

  16. Inhibition by Woodchuck Hepatitis Virus of Class I Major Histocompatibility Complex Presentation on Hepatocytes Is Mediated by Virus Envelope Pre-S2 Protein and Can Be Reversed by Treatment with Gamma Interferon

    Microsoft Academic Search

    Jinguo Wang; Tomasz I. Michalak

    2006-01-01

    Presentation of class I major histocompatibility complex (MHC) is severely down-regulated on hepatocytes in chronic hepatitis caused by woodchuck hepatitis virus (WHV). To determine which of the viral proteins mediates class I MHC antigen suppression, cultured normal woodchuck hepatocytes were transfected with the complete WHV genome, sequences encoding individual virus proteins, or whole virus genomes in which transcription of selected

  17. Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases

    PubMed Central

    Gumilar, Fernanda; Boeris, Mónica; Toso, Ricardo; Minetti, Alejandra

    2014-01-01

    Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole). A therapeutic dose of 28?mg/kg was tested for [Cu(fen)2(im)2] and 21?mg/kg was employed for Fenoprofen calcium, administered by oral gavage in female mice to compare the therapeutic properties of the new entity. The acetic acid induced writhing test was employed to study visceral pain. The percentage of inhibition in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] and Fenoprofen calcium, respectively. This result indicates that the complex could be more effective in diminishing visceral pain. The formalin test was evaluated to study the impact of the drugs over nociceptive and inflammatory pain. The complex is a more potent analgesic on inflammatory pain than the parent drug. Ulcerogenic effects were evaluated using a model of gastric lesions induced by hypothermic-restraint stress. Fenoprofen calcium salt caused an ulcer index of about 79?mm2 while the one caused by [Cu(fen)2(im)2] was 22?mm2. The complex diminished the development of gastric mucosal ulcers in comparison to the uncomplexed drug. Possible mechanisms of action related to both therapeutic properties have been discussed. PMID:25050353

  18. [Tuberculosis treatment].

    PubMed

    Ben Amar, J; Dhahri, B; Aouina, H; Azzabi, S; Baccar, M A; El Gharbi, L; Bouacha, H

    2015-01-01

    The aim of this article is to give practicing physicians a practical approach to the treatment of latent and active tuberculosis. Most patients follow TB standard treatment recommended by WHO that depend on category of patient. It is a combination of four essential tuberculosis drugs of the first group: isoniazid, rifampicin, pyrazinamid and ethambutol; in some cases streptomycin can replace ethambutol. This initial phase of intensive treatment is followed by a consolidation phase. Drugs should be administered in the morning on an empty stomach one hour before meals. Treatment of latent tuberculosis (TB) infection is an important component of TB control programs. Preventive treatment can reduce the risk of developing active TB. PMID:25434510

  19. The crystal structure of 4-methyl-2,6-dibenzoylphenol and its conversion into a mononuclear cobalt(III) complex by treatment with cobalt(II) chloride and propane-1,3-diamine

    Microsoft Academic Search

    Sushil K Gupta; Peter B Hitchcock; Yogendra S Kushwah

    2002-01-01

    The mononuclear cobalt(III) complex [Co(L)2]Cl (1) (where HL is H2N(CH2)3NC(Ph)C6H2(Me)(OH)COPh) has been synthesized by condensation of 4-methyl-2,6-dibenzoylphenol (mdbp) I and propane-1,3-diamine in the presence of CoCl2·6H2O. Compound 1 has been characterized by mass, IR, electronic, 1H and 13C NMR spectroscopy, conductivity measurements, elemental analysis, TGA, cyclic voltammetry and an X-ray structure determination of the solid complex 1·2EtOH·H2NCH2CH2CH2NH2. The cobalt(III) coordination

  20. Water Treatment

    NSDL National Science Digital Library

    This web site showcases Lenntech's Complete Water treatment and Air filtration solutions. This company designs, manufactures and installs complete air and water treatment system solutions. Lenntech proclaims, "Our wide range of technologies and extended know-how in all water-related sectors will guarantee you a cost-efficient solution meeting your water quality requirements." Whether or not you're looking to purchase one of these fine water treatment systems, the site will still provide beneficial resources about how said systems operate.

  1. Sewage Treatment

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A million gallon-a-day sewage treatment plant in Huntington Beach, CA converts solid sewage to activated carbon which then treats incoming waste water. The plant is scaled up 100 times from a mobile unit NASA installed a year ago; another 100-fold scale-up will be required if technique is employed for widespread urban sewage treatment. This unique sewage-plant employed a serendipitous outgrowth of a need to manufacture activated carbon for rocket engine insulation. The process already exceeds new Environmental Protection Agency Standards Capital costs by 25% compared with conventional secondary treatment plants.

  2. Repair of complex parastomal hernias.

    PubMed

    Hwang, G S; Hanna, M H; Carmichael, J C; Mills, S D; Pigazzi, A; Stamos, M J

    2015-03-01

    Development of parastomal hernias (PH) is very common after stoma formation and carries a risk of subsequent bowel incarceration, obstruction and strangulation. The management of PH remains a challenge for the colorectal surgeon, and there are currently no standardized guidelines for the treatment of PH. Even more difficult is the management of complex parastomal hernias (CPH). We conducted a review of the literature to identify recent developments in the treatment of CPH, including analysis of the use of synthetic and biologic mesh prostheses, method of mesh placement and surgical approach. PMID:25732736

  3. Therapeutic Doll Making in Art Psychotherapy for Complex Trauma

    ERIC Educational Resources Information Center

    Stace, Sonia M.

    2014-01-01

    Therapeutic doll making can hold diverse functions for clients in therapy, particularly for those clients who are working through complex trauma histories. Recent literature pertaining to the treatment of complex trauma suggests that talking treatments have their limits; supplementary therapeutic approaches that focus on sensory, physical,…

  4. Salmonellosis Treatment

    MedlinePLUS

    ... Content Marketing Share this: Main Content Area Treatment Salmonella infections usually resolve in 5-7 days and ... can treat it with antibiotics. Some strains of Salmonella have become resistant to several antibiotics normally used ...

  5. Systemic treatment.

    PubMed

    Reig, Maria; Gazzola, Alessia; Di Donato, Roberto; Bruix, Jordi

    2014-10-01

    In the last years the management of patients with liver cancer has been improved. The BCLC staging/treatment strategy identifies the optimal candidates for each treatment option and sorafenib is the only effective systemic treatment. Others (sunitinib, brivanib, linifanib, everolimus, ramucirumab) have failed in terms of safety/survival benefit. Some patients at intermediate/early stage, may be considered for systemic therapy when options of higher priority may have failed or not be feasible. The 800 mg/day is the recommended starting dose. Close follow-up and easy access for the patients so that they can report any adverse event and implement dose adjustments is the key point in the management of them. Development of early dermatologic adverse events has been correlated with better outcome and the pattern of radiologic progression characterizes better the prognosis/outcome of these patients. Treatment beyond progression may be considered if there is no option for a second line research trial. PMID:25260318

  6. Norovirus Treatment

    MedlinePLUS

    ... Norovirus Infection, National Institutes of Health NoroCORE Food Virology Treatment Recommend on Facebook Tweet Share Compartir There ... Norovirus Infection, National Institutes of Health NoroCORE Food Virology File Formats Help: How do I view different ...

  7. Treatment Options

    MedlinePLUS

    ... with this treatment: since the concentration of each coagulation factor in FFP is low, a large volume ... concentrations than FFP of some (but not all) coagulation factors, so less volume is needed. It is ...

  8. Scabies: Treatment

    MedlinePLUS

    ... message, please visit this page: About CDC.gov . Parasites - Scabies Parasites Home Share Compartir Treatment On This Page Suggested ... Cases Publications Information For: Institutions Travelers Related Links Parasites A-Z Index Parasites Glossary Neglected Tropical Diseases ...

  9. HPV Treatment

    MedlinePLUS

    ... Links Sexually Transmitted Diseases HPV-Associated Cancers Gynecologic Cancers ... but there are treatments for the problems that HPV can cause: Visible genital warts may remain the same, grow more numerous, or ...

  10. Wastewater Treatment.

    ERIC Educational Resources Information Center

    Zoltek, J., Jr.; Melear, E. L.

    1978-01-01

    Presents the 1978 literature review of wastewater treatment. This review covers: (1) process application; (2) coagulation and solids separation; (3) adsorption; (4) ion exchange; (5) membrane processes; and (6) oxidation processes. A list of 123 references is also presented. (HM)

  11. Wastewater Treatment

    NSDL National Science Digital Library

    Bianca Pedersen

    Before this activity the students will have heard about groundwater and water resources through lecture to give them a background on where our drinking water comes from. The activity involves a tour of the local wastewater treatment plant where the students told about the treatment processes and shown the treatment facility. They are also introduced to the water quality testing done at the plans and they learn about the energy usage/management at the plant. As part of the activity they write up a paper on the processes in the treatment process from the time water enters the plant until it exits. The students are encouraged before hand to ask questions to ensure that they gather the needed information. This always means that each tour has a slightly different content based on these questions.

  12. Antitumor effects of electrochemical treatment

    PubMed Central

    González, Maraelys Morales; Zamora, Lisset Ortíz; Cabrales, Luis Enrique Bergues; Sierra González, Gustavo Victoriano; de Oliveira, Luciana Oliveira; Zanella, Rodrigo; Buzaid, Antonio Carlos; Parise, Orlando; Brito, Luciana Macedo; Teixeira, Cesar Augusto Antunes; Gomes, Marina das Neves; Moreno, Gleyce; Feo da Veiga, Venicio; Telló, Marcos; Holandino, Carla

    2013-01-01

    Electrochemical treatment is an alternative modality for tumor treatment based on the application of a low intensity direct electric current to the tumor tissue through two or more platinum electrodes placed within the tumor zone or in the surrounding areas. This treatment is noted for its great effectiveness, minimal invasiveness and local effect. Several studies have been conducted worldwide to evaluate the antitumoral effect of this therapy. In all these studies a variety of biochemical and physiological responses of tumors to the applied treatment have been obtained. By this reason, researchers have suggested various mechanisms to explain how direct electric current destroys tumor cells. Although, it is generally accepted this treatment induces electrolysis, electroosmosis and electroporation in tumoral tissues. However, action mechanism of this alternative modality on the tumor tissue is not well understood. Although the principle of Electrochemical treatment is simple, a standardized method is not yet available. The mechanism by which Electrochemical treatment affects tumor growth and survival may represent more complex process. The present work analyzes the latest and most important research done on the electrochemical treatment of tumors. We conclude with our point of view about the destruction mechanism features of this alternative therapy. Also, we suggest some mechanisms and strategies from the thermodynamic point of view for this therapy. In the area of Electrochemical treatment of cancer this tool has been exploited very little and much work remains to be done. Electrochemical treatment constitutes a good therapeutic option for patients that have failed the conventional oncology methods. PMID:23592904

  13. The effects of infrared laser therapy and weightbath traction hydrotherapy as components of complex physical treatment in disorders of the lumbar spine: a controlled pilot study with follow-up

    NASA Astrophysics Data System (ADS)

    Oláh, Csaba; Oláh, Mihály; Demeter, Béla; Jancsó, Zoltán; Páll, Valéria; Bender, Tamás

    2010-02-01

    Introduction: The therapeutic modalities available for the conservative management of chronic lumbar pain included infrared laser therapy and underwater traction, which usefulness is not universally acknowledged. This study was intended to ascertain any beneficial impact of infrared laser therapy and weightbath treatment on the clinical parameters and quality of life of patients with lumbar discopathy. Material and methods: The study population comprised 54 randomised subjects. I. group of 18 patents received only infrared laser therapy to lumbar region and painful Valley points. II. group of 18 subjects each received underwater traction therapy of lumbar spine with add-on McKenzie exercise and iontophoresis. The remaining III. group treated with exercise and iontophoresis, served as control. VAS, Oswestry index, SF36 scores, range of motion, neurological findings and thermography were monitored to appraise therapeutic afficacy in lumbar discopathy. A CT or MRI scan was done at baseline and after 3 months follow-up. Result:Infrared laser therapy and underwater traction for discopathy achieved significant improvement of all study parameters, which was evident 3 months later. Among the controls, significant improvement of only a single parameter was seen in patients with lumbar discopathy. Conclusions: Infrared laser therapy and underwater traction treatment effectively mitigate pain, muscle spasms, enhance joint flexibility, and improve the quality of life of patients with lumbar discopathy.

  14. [Pharmaceutical treatment of bipolar depression. Evidence from clinical guidelines and treatment recommendations].

    PubMed

    Köhler, S; Bauer, M; Bschor, T

    2014-09-01

    Treatment of bipolar depression requires complex treatment decisions in daily routine care. The best evidence for pharmacological treatment is given for quetiapine and with limitations also in off-label use for lamotrigine, especially in combination with lithium, carbamazepine and olanzapine. Effectiveness and recommendation of antidepressants in treatment of bipolar depression remain controversial because of insufficient data. Initially, in depressive episodes a phase prophylactic treatment should be initiated or (if already existing) optimized and more severe episodes should be treated with the substances described before. In case of non-response, the combination of lithium and lamotrigine or antidepressants in combination with lithium, antiepileptics or atypical antipsychotics may be necessary. If depressive episodes occur in the course of pharmacological treatment with prophylactic agents, combination therapies of different substances, even with antidepressants, are necessary. In case of treatment-resistant depressive episodes, complex treatment strategies (e.g. combination therapies and MAO inhibitors) should be considered. PMID:24170252

  15. Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5

    PubMed Central

    Kitanovic, Ana; Bonowski, Felix; Heigwer, Florian; Ruoff, Peter; Kitanovic, Igor; Ungewiss, Christin; Wölfl, Stefan

    2012-01-01

    Metabolic pathways play an indispensable role in supplying cellular systems with energy and molecular building blocks for growth, maintenance and repair and are tightly linked with lifespan and systems stability of cells. For optimal growth and survival cells rapidly adopt to environmental changes. Accumulation of acetic acid in stationary phase budding yeast cultures is considered to be a primary mechanism of chronological aging and induction of apoptosis in yeast, which has prompted us to investigate the dependence of acetic acid toxicity on extracellular conditions in a systematic manner. Using an automated computer controlled assay system, we investigated and model the dynamic interconnection of biomass yield- and growth rate-dependence on extracellular glucose concentration, pH conditions and acetic acid concentration. Our results show that toxic concentrations of acetic acid inhibit glucose consumption and reduce ethanol production. In absence of carbohydrates uptake, cells initiate synthesis of storage carbohydrates, trehalose and glycogen, and upregulate gluconeogenesis. Accumulation of trehalose and glycogen, and induction of gluconeogenesis depends on mitochondrial activity, investigated by depletion of the Hap2-3-4-5 complex. Analyzing the activity of glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), pyruvate kinase (PYK), and glucose-6-phosphate dehydrogenase (G6PDH) we found that while high acetic acid concentration increased their activity, lower acetic acids concentrations significantly inhibited these enzymes. With this study we determined growth and functional adjustment of metabolism to acetic acid accumulation in a complex range of extracellular conditions. Our results show that substantial acidification of the intracellular environment, resulting from accumulation of dissociated acetic acid in the cytosol, is required for acetic acid toxicity, which creates a state of energy deficiency and nutrient starvation. PMID:23050242

  16. Sewage Treatment

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Stennis Space Center's aquaculture research program has led to an attractive wastewater treatment for private homes. The system consists of a septic tank or tanks for initial sewage processing and a natural secondary treatment facility for further processing of septic tanks' effluent, consisting of a narrow trench, which contains marsh plants and rocks, providing a place for microorganisms. Plants and microorganisms absorb and digest, thus cleansing partially processed wastewater. No odors are evident and cleaned effluent may be discharged into streams or drainage canals. The system is useful in rural areas, costs about $1,900, and requires less maintenance than mechanical systems.

  17. On State Complexes and Special Cube Complexes

    ERIC Educational Resources Information Center

    Peterson, Valerie J.

    2009-01-01

    This thesis presents the first steps toward a classification of non-positively curved cube complexes called state complexes. A "state complex" is a configuration space for a "reconfigurable system," i.e., an abstract system in which local movements occur in some discrete manner. Reconfigurable systems can be used to describe, for example,…

  18. Managing epilepsy in tuberous sclerosis complex.

    PubMed

    Thiele, Elizabeth Anne

    2004-09-01

    Epilepsy is very common in tuberous sclerosis complex and occurs in 80 to 90% of affected individuals during their lifetime. Onset usually occurs during childhood, and up to one third of children with tuberous sclerosis complex will develop infantile spasms. Although not completely understood, the incidence of epilepsy is thought to relate to the neuropathologic features of the disorder, including cortical tubers and other dysgenetic features. Individuals with tuberous sclerosis complex frequently have epileptiform features to their electroencephalograms. Treatment of epilepsy in tuberous sclerosis complex is similar to epilepsy resulting from other causes and includes anticonvulsant medications, the vagus nerve stimulator, and the ketogenic diet. Vigabatrin has been shown to be particularly effective in treating infantile spasms in the setting of tuberous sclerosis complex. Epilepsy surgery has a very important role in the management of children and adults with pharmacoresistant epilepsy in tuberous sclerosis complex. PMID:15563014

  19. Anaerobic treatment

    Microsoft Academic Search

    E. R. Witt; W. J. Humphrey; J. P. Cave

    1982-01-01

    This invention provides for the anaerobic treatment of acidic petrochemical wastes in an anaerobic filter at high loadings and high recycle rates. The effluent from the top of the filter passes into a gas-disengaging\\/solids-settling zone containing a quiescent body of the effluent liquid. The settled solids are withdrawn and recycled to the base of the filter together with fresh acidic

  20. Wastewater Treatment

    NSDL National Science Digital Library

    Water-technology.net web site for the water industry contains links to many sites for detailed information on industrial and municipal wastewater treatment plants as well as water supply and transmission. Also find information on current news releases, expos, conferences and much more.

  1. Implications of the IFRS goodwill accounting treatment

    Microsoft Academic Search

    Graeme Wines; Ron Dagwell; Carolyn Windsor

    2007-01-01

    Purpose – This paper aims to critically examine the change in accounting treatment for goodwill pursuant to international financial reporting standards (IFRSs) by reference to the Australian reporting regime. Design\\/methodology\\/approach – The paper discusses and compares the former Australian and the new IFRS treatments for goodwill. This comparison focuses on the advantages and potential complexities of the new method, with

  2. Fluoroquinolone-Gyrase-DNA Complexes

    PubMed Central

    Mustaev, Arkady; Malik, Muhammad; Zhao, Xilin; Kurepina, Natalia; Luan, Gan; Oppegard, Lisa M.; Hiasa, Hiroshi; Marks, Kevin R.; Kerns, Robert J.; Berger, James M.; Drlica, Karl

    2014-01-01

    DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex DNA through the break, and then resealing the break. This process is subject to reversible corruption by fluoroquinolones, antibacterials that form drug-enzyme-DNA complexes in which the DNA is broken. The complexes, called cleaved complexes because of the presence of DNA breaks, have been crystallized and found to have the fluoroquinolone C-7 ring system facing the GyrB/ParE subunits. As expected from x-ray crystallography, a thiol-reactive, C-7-modified chloroacetyl derivative of ciprofloxacin (Cip-AcCl) formed cross-linked cleaved complexes with mutant GyrB-Cys466 gyrase as evidenced by resistance to reversal by both EDTA and thermal treatments. Surprisingly, cross-linking was also readily seen with complexes formed by mutant GyrA-G81C gyrase, thereby revealing a novel drug-gyrase interaction not observed in crystal structures. The cross-link between fluoroquinolone and GyrA-G81C gyrase correlated with exceptional bacteriostatic activity for Cip-AcCl with a quinolone-resistant GyrA-G81C variant of Escherichia coli and its Mycobacterium smegmatis equivalent (GyrA-G89C). Cip-AcCl-mediated, irreversible inhibition of DNA replication provided further evidence for a GyrA-drug cross-link. Collectively these data establish the existence of interactions between the fluoroquinolone C-7 ring and both GyrA and GyrB. Because the GyrA-Gly81 and GyrB-Glu466 residues are far apart (17 ?) in the crystal structure of cleaved complexes, two modes of quinolone binding must exist. The presence of two binding modes raises the possibility that multiple quinolone-enzyme-DNA complexes can form, a discovery that opens new avenues for exploring and exploiting relationships between drug structure and activity with type II DNA topoisomerases. PMID:24497635

  3. Fixation of atmospheric carbon dioxide by ruthenium complexes bearing an NHC-based pincer ligand: formation of a methylcarbonato complex and its methylation.

    PubMed

    Arikawa, Yasuhiro; Nakamura, Takuo; Ogushi, Shinji; Eguchi, Kazushige; Umakoshi, Keisuke

    2015-03-28

    A methylcarbonato ruthenium complex was prepared by capture of CO2 from air using the (CNC)(bpy)Ru scaffold. The methylcarbonato complex was relatively inert to decarboxylation. Treatments with methylating reagents released dimethylcarbonate. PMID:25711491

  4. Complex-scaling Fourier-grid Hamiltonian method. III. Oscillatory behavior of complex quasienergies and the stability of negative ions in very intense laser fields

    E-print Network

    Chu, Shih-I; Yao, Guanhua

    1992-05-01

    A complex-scaling Fourier-grid Hamiltonian (CSFGH) method in momentum representation along with Floquet formalism is presented and applied to the nonperturbative treatment of the complex quasienergies of a one-dimensional-model ...

  5. On the use of explicitly correlated treatment methods for the generation of accurate polyatomic -He/H2 interaction potential energy surfaces: The case of C3-He complex and generalization.

    PubMed

    Al Mogren, M M; Denis-Alpizar, O; Ben Abdallah, D; Stoecklin, T; Halvick, P; Senent, M-L; Hochlaf, M

    2014-07-28

    Through the study of the C3(X1?g (+)) (1)?g (+)) + He((1)S) astrophysical relevant system using standard (CCSD(T)) and explicitly correlated (CCSD(T)-F12) coupled cluster approaches, we show that the CCSD(T)-F12/aug-cc-pVTZ level represents a good compromise between accuracy and low computational cost for the generation of multi-dimensional potential energy surfaces (PESs) over both intra- and inter-monomer degrees of freedom. Indeed, the CCSD(T)-F12/aug-cc-pVTZ 2D-PES for linear C3 and the CCSD(T)-F12/aug-cc-pVTZ 4D-PES for bent C3 configurations gently approach those mapped at the CCSD(T)/aug-cc-pVXZ (X = T,Q) + bond functions level, whereas a strong reduction of computational effort is observed. After exact dynamical computations, the pattern of the rovibrational levels of the intermediate C3-He complex and the rotational and rovibrational (de-) excitation of C3 by He derived using both sets of PESs agree quite well. Since C3 shows a floppy character, the interaction PES is defined in four dimensions to obtain realistic collisional parameters. The C-C-C bending mode, which fundamental lies at 63 cm(-1) and can be excited at very low temperatures is explicitly considered as independent coordinate. Our work suggests hence that CCSD(T)-F12/aug-cc-pVTZ methodology is the key method for the generation of accurate polyatomic - He/H2 multi-dimensional PESs. PMID:25084911

  6. Bench-to-bedside review: The evaluation of complex interventions in critical care

    Microsoft Academic Search

    Anthony Delaney; Derek C Angus; Rinaldo Bellomo; Peter Cameron; D James Cooper; Simon Finfer; David A Harrison; David T Huang; John A Myburgh; Sandra L Peake; Michael C Reade; Steve AR Webb; Donald M Yealy

    2008-01-01

    Complex interventions, such as the introduction of medical emergency teams or an early goal-directed therapy protocol, are developed from a number of components that may act both independently and inter-dependently. There is an emerging body of literature advocating the use of integrated complex interventions to optimise the treatment of critically ill patients. As with any other treatment, complex interventions should

  7. Early treatment

    Microsoft Academic Search

    G. Comi

    2006-01-01

    Class I clinical trials demonstrated that immunomodulatory treatments (interferon-? and glatiramer acetate) reduce the disease\\u000a activity and the accumulation of disability in relapsing–remitting multiple sclerosis (MS). Moreover, interferon-?-1b had\\u000a similar positive effects also in secondary progressive MS. The magnitude of these clinical effects was modest, but the reduction\\u000a of inflammatory activity, as revealed by magnetic resonance imaging, was marked. There

  8. Treatment Time

    Microsoft Academic Search

    C. Chazot; G. Jean

    2008-01-01

    The session duration for hemodialysis (HD) patients has become an old-fashioned issue since the blooming debate on dialysis frequency. However, all over the dialysis community, the most frequent scheme of HD treatment remains three-weekly sessions. Pursuing long dialysis strategy 3 times\\/week for ESRD patients in Tassin after the retirement of the historical leaders relies on the wisdom pillars of dialysis

  9. Novel wastewater treatment processes

    SciTech Connect

    Saber, D.L. [Inst. of Gas Technology, Des Plaines, IL (United States)

    1996-12-31

    Few fermentation processes are as versatile as anaerobic digestion in terms of utility, application and capability to handle feeds of varied chemical complexity and physical characteristics. The anaerobic digestion process has served the pollution control industry in the US for over 100 years in stabilizing organic sludges and wastewaters; treatment of these high-moisture-content and high-strength aqueous wastes by alternative thermal or aerobic biological processes requires much higher energy inputs than that needed to conduct anaerobic digestion. The anaerobic digestion process has taken on new importance and emphasis in recent years because of its potential application for energy and chemical production from various types of renewable-carbon resources, and because it can be coupled with certain electrochemical, thermochemical and biochemical processes to generate electric power, hydrocarbons, methanol and other high-value products. A number of initiatives have been taken to improve the anaerobic digestion process in keeping with the increasing appreciation for its utility and versatility of application in municipal, industrial and rural settings. Using processes based upon the anaerobic digestion of organic wastes, the Institute of Gas Technology has developed technologies applicable for the treatment of a wide variety of organic wastes. Increased methane gas production and enhanced waste reduction can be achieved through the ACIMET, SOLCON and HIMET Processes, depending upon concentration and characteristics of the incoming organic waste stream. These proprietary IGT waste treatment systems are described.

  10. Evaluating Software Complexity Measures

    Microsoft Academic Search

    Elaine J. Weyuker

    1988-01-01

    A set of properties of syntactic software complexity measures is proposed to serve as a basis for the evaluation of such measures. Four known complexity measures are evaluated and compared using these criteria. This formalized evaluation clarifies the strengths and weaknesses of the examined complexity measures, which include the statement count, cyclomatic number, effort measure, and data flow complexity measures.

  11. Bypasses and Reconstruction for Complex Brain Aneurysms

    PubMed Central

    da Silva, Harley Brito; Messina-Lopez, Mario; Sekhar, Laligam N.

    2014-01-01

    Microsurgery for brain aneurysms is a current relevant technique, as advances in endovascular and stent-assisted coiling have not solved many of the difficulties inherent in the management of complex brain aneurysms. The following review highlights the importance of microsurgical bypass techniques for the management of complex cerebrovascular aneurysms and emphasizes, through two clinical cases, the technical difficulties and indications for bypass surgery. These cases demonstrate that in selected scenarios, bypass microsurgery still offers the only viable treatment for complex aneurysms. PMID:25624977

  12. Sewage Treatment

    NASA Technical Reports Server (NTRS)

    1984-01-01

    In the early 1970's, National Space Technology Laboratories discovered that water hyacinths literally thrive on sewage; they absorb and digest nutrients and minerals from wastewater, converting sewage effluents to clean water. They offer a means of purifying water at a fraction of the cost of a conventional sewage treatment plant, and provide a bonus value in byproducts. Hyacinths must be harvested at intervals; the harvested plants are used as fertilizers, high-protein animal feed and a source of energy. Already serving a number of small towns, the "aquaculture" technique has significantly advanced with its adoption by a major U.S. city.

  13. Protein Complexes in Bacteria

    PubMed Central

    Caufield, J. Harry; Abreu, Marco; Wimble, Christopher; Uetz, Peter

    2015-01-01

    Large-scale analyses of protein complexes have recently become available for Escherichia coli and Mycoplasma pneumoniae, yielding 443 and 116 heteromultimeric soluble protein complexes, respectively. We have coupled the results of these mass spectrometry-characterized protein complexes with the 285 “gold standard” protein complexes identified by EcoCyc. A comparison with databases of gene orthology, conservation, and essentiality identified proteins conserved or lost in complexes of other species. For instance, of 285 “gold standard” protein complexes in E. coli, less than 10% are fully conserved among a set of 7 distantly-related bacterial “model” species. Complex conservation follows one of three models: well-conserved complexes, complexes with a conserved core, and complexes with partial conservation but no conserved core. Expanding the comparison to 894 distinct bacterial genomes illustrates fractional conservation and the limits of co-conservation among components of protein complexes: just 14 out of 285 model protein complexes are perfectly conserved across 95% of the genomes used, yet we predict more than 180 may be partially conserved across at least half of the genomes. No clear relationship between gene essentiality and protein complex conservation is observed, as even poorly conserved complexes contain a significant number of essential proteins. Finally, we identify 183 complexes containing well-conserved components and uncharacterized proteins which will be interesting targets for future experimental studies. PMID:25723151

  14. Complex emergencies in Indonesia.

    PubMed

    Bradt, D A; Drummond, C M; Richman, M

    2001-01-01

    Recently, Indonesia has experienced six major provincial, civil, armed conflicts. Underlying causes include the transmigration policy, sectarian disputes, the Asian economic crisis, fall of authoritarian rule, and a backlash against civil and military abuses. The public health impact involves the displacement nationwide of > 1.2 million persons. Violence in the Malukus, Timor, and Kalimantan has sparked the greatest population movements such that five provinces in Indonesia each now harbor > 100,000 internally displaced persons. With a background of government instability, hyperinflation, macroeconomic collapse, and elusive political solutions, these civil armed conflicts are ripe for persistence as complex emergencies. Indonesia has made substantial progress in domestic disaster management with the establishment of central administrative authority, strategic planning, and training programs. Nevertheless, the Indonesian experience reveals recurrent issues in international humanitarian health assistance. Clinical care remains complicated by absences of treatment protocols, inappropriate drug use, high procedural complication rates, and variable referral practices. Epidemiological surveillance remains complicated by unsettled clinical case definitions, non-standardized case management of diseases with epidemic potential, variable outbreak management protocols, and inadequate epidemiological analytic capacity. International donor support has been semi-selective, insufficient, and late. The militia murders of three UN staff in West Timor prompted the withdrawal of UN international staff from West Timor for nearly a year to date. Re-establishing rules of engagement for humanitarian health workers must address security, public health, and clinical threats. PMID:12090212

  15. Hip dislocations--epidemiology, treatment, and outcomes.

    PubMed

    Clegg, Travis E; Roberts, Craig S; Greene, Joseph W; Prather, Brad A

    2010-04-01

    Traumatic dislocations of the hip appear to be on the rise in North America. Multidetector CT, hip arthroscopy, and high field MRI have further defined the pathoanatomy of hip dislocations. They can be divided into simple and complex dislocations. At the University of Louisville, an algorithm has been developed to facilitate rapid and accurate diagnosis and treatment of simple hip dislocations. In contrast to the treatment of simple hip dislocations, the treatment of complex hip dislocations (fracture-dislocations) is generally predicated on specific treatments of the associated fracture (e.g., femoral head fracture, femoral neck fracture, acetabular fracture, etc.). This review includes the mechanism of injury, epidemiology, associated injuries, evaluation, treatment, and functional outcomes of simple hip dislocations. PMID:19796765

  16. Complex networks analysis of language complexity

    E-print Network

    Amancio, Diego R; Oliveira, Osvaldo N; Costa, Luciano da F; 10.1209/0295-5075/100/58002

    2013-01-01

    Methods from statistical physics, such as those involving complex networks, have been increasingly used in quantitative analysis of linguistic phenomena. In this paper, we represented pieces of text with different levels of simplification in co-occurrence networks and found that topological regularity correlated negatively with textual complexity. Furthermore, in less complex texts the distance between concepts, represented as nodes, tended to decrease. The complex networks metrics were treated with multivariate pattern recognition techniques, which allowed us to distinguish between original texts and their simplified versions. For each original text, two simplified versions were generated manually with increasing number of simplification operations. As expected, distinction was easier for the strongly simplified versions, where the most relevant metrics were node strength, shortest paths and diversity. Also, the discrimination of complex texts was improved with higher hierarchical network metrics, thus point...

  17. Integration methods for complex plastic constitutive equations

    Microsoft Academic Search

    J. L. Chaboche; G. Cailletaud

    1996-01-01

    This paper shows new results concerning the Finite Element computations with complex plastic and viscoplastic constitutive equations. The integration procedure then needs special numerical treatments when a large number of internal variables are present, or for stiff non-linearities. Implicit and explicit integration methods are compared. The general solution proposed can be applied either in plasticity or in viscoplasticity, for isotropic

  18. Anaerobic treatment

    SciTech Connect

    Witt, E.R.; Humphrey, W.J.; Cave, J.P.

    1982-12-28

    This invention provides for the anaerobic treatment of acidic petrochemical wastes in an anaerobic filter at high loadings and high recycle rates. The effluent from the top of the filter passes into a gas-disengaging/solids-settling zone containing a quiescent body of the effluent liquid. The settled solids are withdrawn and recycled to the base of the filter together with fresh acidic waste and an inorganic alkaline material (preferably magnesium oxide or carbonate) to maintain a neutral pH. The liquid portion of the effluent is sent to an aerobic digester to remove the rest of the organic material, which is used to support the growth of bacteria and fed back to the anaerobic system.

  19. MRSA (treatment)

    PubMed Central

    2006-01-01

    Introduction Methicillin-resistant Staphylococcus aureus (MRSA) has a gene that makes it resistant to methicillin as well as to other beta lactam antibiotics including flucloxacillin, b-lactam/b-lactamase inhibitor combinations, cephalosporins, and carbapenems. MRSA can be part of the normal body flora (colonisation), especially in the nose, but can cause infection, especially in people with prolonged hospital admissions, with underlying disease, or after antibiotic use. About 40% of S aureus in blood cultures in the UK is resistant to methicillin. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatment for MRSA infections at any body site? What are the effects of treatment for MRSA nasal or extra-nasal colonisation? We searched: Medline, Embase, The Cochrane Library and other important databases up to July 2005 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 16 systematic reviews, RCTs, or observational studies that met our inclusion criteria. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiseptic body washes, chlorhexidine-neomycin nasal cream, clindamycin, daptomycin, fusidic acid, glycopeptides (teicoplanin, vancomycin), linezolid, macrolides (azithromycin, clarithromycin, erythromycin), mupirocin nasal ointment, quinolones (ciprofloxacin, levofloxacin, moxifloxacin), quinupristin-dalfopristin, rifampicin, systemic antimicrobials, tea tree preparations, tetracyclines (doxycycline, minocycline, oxytetracycline), trimethoprim, and trimethoprim-sulfamethoxazole.

  20. Assessment and Treatment of Personality Disorders: A Behavioral Perspective

    ERIC Educational Resources Information Center

    Nelson-Gray, Rosemery O.; Lootens, Christopher M.; Mitchell, John T.; Robertson, Christopher D.; Hundt, Natalie E.; Kimbrel, Nathan A.

    2009-01-01

    Personality disorders are complex and highly challenging to treatment providers; yet, for clients with these problems, there exist very few treatment options that have been supported by research. Given the lack of empirically-supported therapies for personality disorders, it can be difficult to make treatment decisions for this population. The…

  1. Causal Inference for Time-Varying Instructional Treatments

    Microsoft Academic Search

    Guanglei Hong; Stephen W. Raudenbush

    2008-01-01

    The authors propose a strategy for studying the effects of time-varying instructional treatments on repeatedly observed student achievement. This approach responds to three challenges: (a) The yearly reallocation of students to classrooms and teachers creates a complex structure of dependence among responses; (b) a child’s learning outcome under a certain treatment may depend on the treatment assignment of other children,

  2. Osteopathic Manipulative Treatment

    PubMed Central

    Campbell, Shannon M.; Walkowski, Stevan

    2012-01-01

    Dermatological diseases, such as dysesthesia syndromes, stasis dermatoses, and hyperhidrosis are difficult to treat due to their complex etiologies. Current theories suggest these diseases are caused by physiological imbalances, such as nerve impingement, localized tissue congestion, and impaired autonomic regulation. Osteopathic manipulative therapy targets these physiological dysfunctions and may serve as a beneficial therapeutic option. Osteopathic manipulative therapy techniques include high velocity low amplitude, muscle energy, counterstrain, myofascial release, craniosacral, and lymphatic drainage. An osteopathic manipulative therapy technique is chosen based on its physiological target for a particular disease. Osteopathic manipulative therapy may be useful alone or in combination with standard therapeutic options. However, due to the lack of standardized trials supporting the efficacy of osteopathic manipulative therapy treatment for dermatological disease, randomized, well-controlled studies are necessary to confirm its therapeutic value. PMID:23125887

  3. Complex Elliptic Pendulum

    E-print Network

    Carl M. Bender; Daniel W. Hook; Karta Kooner

    2009-12-31

    This paper briefly summarizes previous work on complex classical mechanics and its relation to quantum mechanics. It then introduces a previously unstudied area of research involving the complex particle trajectories associated with elliptic potentials.

  4. Oligocyclopentadienyl transition metal complexes

    SciTech Connect

    de Azevedo, Cristina G.; Vollhardt, K. Peter C.

    2002-01-18

    Synthesis, characterization, and reactivity studies of oligocyclopentadienyl transition metal complexes, namely those of fulvalene, tercyclopentadienyl, quatercyclopentadienyl, and pentacyclopentadienyl(cyclopentadienyl) are the subject of this account. Thermal-, photo-, and redox chemistries of homo- and heteropolynuclear complexes are described.

  5. Software complexity measurement

    Microsoft Academic Search

    Joseph P. Kearney; Robert L. Sedlmeyer; William B. Thompson; Michael A. Gray; Michael A. Adler

    1986-01-01

    Inappropriate use of software complexity measures can have large, damaging effects by rewarding poor programming practices and demoralizing good programmers. Software complexity measures must be critically evaluated to determine the ways in which they can best be used.

  6. Imprinted Polymers in Wastewater Treatment

    SciTech Connect

    Eastman, Christopher; Goodrich, Scott; Gartner, Isabelle; Mueller, Anja

    2004-03-31

    In wastewater treatment, a method that specifically recognizes a variety of impurities in a flexible manner would be useful for treatment facilities with varying needs. Current purification techniques (i.e. bacteria, oxidation, reduction, precipitation and filtration) are nonspecific and difficult to control in complex mixtures. Heavy metal removal is particularly important in improving the efficiency of wastewater treatment, as they inhibit or even destroy the bacteria used for filtration. Imprinting polymerization is a technique that allows for the efficient removal of specific compounds and has been used in purification of enantiomers. It has potential to be applied in wastewater systems with the impurities acting as the template for the imprinting polymerization. The polymer with the bound impurities intact can then be removed via precipitation. After removal of the impurity the polymer can be reused. Data for the imprinting polymerization of polyacrylates and polyacrylamides for several metal complexes will be presented. Imprinting polymerization in combination with emulsion polymerization to improve the removal of hydrophobic contaminants will be described. Removal efficiencies will be presented and compared with conventional wastewater treatment methods.

  7. Complex numbers Quaternions

    E-print Network

    Complex numbers Quaternions Imaginary numbers and Quaternions Katrin Leschke University of Leicester June 29, 2010 Katrin Leschke Imaginary numbers and Quaternions #12;Complex numbers Quaternions Imaginary numbers and Quaternions #12;Complex numbers Quaternions Vectors in 2d­space A vector in 2d

  8. Quaternionic Complexes Andreas Cap

    E-print Network

    Drmota, Michael

    Quaternionic Complexes Andreas Cap University of Vienna Berlin, March 2007 Andreas Cap (University of Vienna) Quaternionic Complexes Berlin, March 2007 1 / 19 #12;based on the joint article math.DG/0508534 with V. Soucek (Prague) Andreas Cap (University of Vienna) Quaternionic Complexes Berlin, March 2007 2

  9. A Complexity Measure

    Microsoft Academic Search

    Thomas J. McCabe

    1976-01-01

    This paper describes a graph-theoretic complexity measure and illustrates how it can be used to manage and control program complexity. The paper first explains how the graph theory concepts apply and gives an intuitive explanation of the graph concepts in programming terms. The control graphs of several actual FORTRAN programs are then presented to illustrate the correlation between intuitive complexity

  10. Simple lessons from complexity

    PubMed

    Goldenfeld; Kadanoff

    1999-04-01

    The complexity of the world is contrasted with the simplicity of the basic laws of physics. In recent years, considerable study has been devoted to systems that exhibit complex outcomes. This experience has not given us any new laws of physics, but has instead given us a set of lessons about appropriate ways of approaching complex systems. PMID:10102823

  11. Software complexity and maintainability

    Microsoft Academic Search

    Rajiv D. Banker; Srikant M. Datar; Dani Zweig

    1989-01-01

    This paper examines the relationships between software complexity and software maintainability in commercial software environments. Models are proposed for estimating the economic impacts of software complexity and for identifying the factors which affect a system's complexity. Empirical work currently under way has shown these models to be implementable.

  12. Profiling software complexity

    Microsoft Academic Search

    Patricia A. Mcquaid

    1995-01-01

    This paper deals with a new perspective on complexity metrics and their uses during the testing phase of software development. In keeping with traditional viewpoints, the complexity of a code fragment is assumed to be correlated with its error-proneness or its maintenance difficulty, so that the higher the complexity, the more likely the existence of errors. While the theories advocated

  13. Minimal atomic complexes

    Microsoft Academic Search

    A. J. Baker; J. P. May

    2004-01-01

    We define minimal atomic complexes and irreducible complexes, and we prove that they are the same. The irreducible complexes admit homological characterizations that make them easy to recognize. These concepts apply both to spaces and to spectra. On the spectrum level, our characterizations allow us to show that such familiar spectra as ko, eo2, and BoP at the prime 2,

  14. Posterior crossbite - treatment and stability

    PubMed Central

    de ALMEIDA, Renato Rodrigues; de ALMEIDA, Marcio Rodrigues; OLTRAMARI-NAVARRO, Paula Vanessa Pedron; CONTI, Ana Cláudia de Castro Ferreira; NAVARRO, Ricardo de Lima; MARQUES, Henry Victor Alves

    2012-01-01

    Posterior crossbite is defined as an inadequate transversal relationship of maxillary and mandibular teeth. Even when eliminating the etiologic factors, this malocclusion does not have a spontaneous correction, and should be treated with maxillary expansion as early as possible. This treatment aims at providing a better tooth/skeletal relationship, thereby improving masticatory function, and establishing a symmetrical condyle/fossa relationship. Should posterior crossbite not be treated early, it may result in skeletal changes, demanding a more complex approach. Additionally, an overcorrection expansion protocol should be applied in order to improve the treatment stability. Although the literature has reported a high rate of relapse after maxillary expansion, the goal of this study was to demonstrate excellent stability of the posterior crossbite correction 21 years post treatment. PMID:22666850

  15. A consistent modelling methodology for secondary settling tanks in wastewater treatment

    E-print Network

    Bürger, Raimund

    A consistent modelling methodology for secondary settling tanks in wastewater treatment Stefan on a consistent modelling methodology (CMM) of complex real processes in wastewater treatment by utilizing both as a case since this is one of the most complex processes in a wastewater treatment plant and the simulation

  16. Periodontal Treatments and Procedures

    MedlinePLUS

    ... Procedures Non-Surgical Periodontal Treatments Gum Graft Surgery Laser Treatment for Gum Disease Regenerative Procedures Dental Crown Lengthening ... dental implants. Non-Surgical Treatments Gum Graft Surgery Laser Treatment Regenerative Procedures Dental Crown Lengthening Dental Implants Pocket ...

  17. Amblyopia: Lazy Eye Treatment

    MedlinePLUS

    ... Sun Eye Health News Consumer Alerts Amblyopia: Lazy Eye Treatment Tweet Lazy eye correction or treatment should ... Lazy Eye Diagnosis Amblyopia: Lazy Eye Treatment Lazy eye patch treatment If refractive amblyopia is a problem, ...

  18. Endodontic Treatment in Children

    MedlinePLUS

    ... Baby) Teeth Primary Teeth: Root Canal Treatment vs. Extraction After Endodontic Treatment Endodontic treatment involves the pulp ... one visit. Primary Teeth: Root Canal Treatment vs. Extraction Your dentist will give you information so you ...

  19. Complex-I-ty in aging.

    PubMed

    Hur, Jae H; Stork, Devon A; Walker, David W

    2014-08-01

    The role of mitochondrial complex I in aging has been studied in both C. elegans and Drosophila, where RNAi knock down of specific complex I subunits has been shown to extend lifespan. More recently, studies in Drosophila have shown that an increase in mitochondrial activity, including complex I-like activity, can also slow aging. In this review, we discuss this apparent paradox. Improved maintenance of mitochondrial activity, mitochondrial homeostasis, may be responsible for lifespan extension in both cases. Decreased electron transport chain activity caused by reducing complex I subunit expression prompts an increase in stress response signaling that leads to enhanced mitochondrial homeostasis during aging. Increased complex I activity, as well as mitochondrial biogenesis, is expected to both directly counteract the decline in mitochondrial health that occurs during aging and may also increase cellular NAD(+) levels, which have been linked to mitochondrial homeostatic mechanisms through activation of sirtuins. We suggest that manipulations that increase or decrease complex I activity both converge on improved mitochondrial homeostasis during aging, resulting in prolonged lifespan. PMID:24961226

  20. Trauma-focused CBT for youth with complex trauma

    PubMed Central

    Mannarino, Anthony P.; Kliethermes, Matthew; Murray, Laura A.

    2013-01-01

    Objectives Many youth develop complex trauma, which includes regulation problems in the domains of affect, attachment, behavior, biology, cognition, and perception. Therapists often request strategies for using evidence-based treatments (EBTs) for this population. This article describes practical strategies for applying Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for youth with complex trauma. Methods TF-CBT treatment phases are described and modifications of timing, proportionality and application are described for youth with complex trauma. Practical applications include a) dedicating proportionally more of the model to the TF-CBT coping skills phase; b) implementing the TF-CBT Safety component early and often as needed throughout treatment; c) titrating gradual exposure more slowly as needed by individual youth; d) incorporating unifying trauma themes throughout treatment; and e) when indicated, extending the TF-CBT treatment consolidation and closure phase to include traumatic grief components and to generalize ongoing safety and trust. Results Recent data from youth with complex trauma support the use of the above TF-CBT strategies to successfully treat these youth. Conclusions The above practical strategies can be incorporated into TF-CBT to effectively treat youth with complex trauma. Practice implications Practical strategies include providing a longer coping skills phase which incorporates safety and appropriate gradual exposure; including relevant unifying themes; and allowing for an adequate treatment closure phase to enhance ongoing trust and safety. Through these strategies therapists can successfully apply TF-CBT for youth with complex trauma. PMID:22749612

  1. NORDIC WASTE WATER TREATMENT SLUDGE TREATMENT

    E-print Network

    -Norway treats source separated household waste (food waste), organic industrial waste (food processingNORDIC WASTE WATER TREATMENT SLUDGE TREATMENT SWEDEN·FINLAND·DENMARK·NORWAY #12;SLUDGE TREATMENT TECHNOLOGY 19 #12;3 Sludge originates from the process of treatment of waste water. Due to the physical

  2. Surprising Titanium Complexes Bearing 2-Pyrazolato Ligands: Synthesis, Structure, and

    E-print Network

    Schlegel, H. Bernhard

    Surprising Titanium Complexes Bearing 2-Pyrazolato Ligands: Synthesis, Structure, and Molecular the synthesis and characterization of several homoleptic pz com- plexes of titanium(IV). These species complexes should be common in early to middle transition metals. Treatment of tetrakis(dimethylamido)titanium

  3. Clinical pathway implementation improves outcomes for complex biliary surgery

    Microsoft Academic Search

    Henry A. Pitt; Kevin P. Murray; Helen M. Bowman; JoAnn Coleman; Toby A. Gordon; Charles J. Yeo; Keith D. Lillemoe; John L. Cameron

    1999-01-01

    Background: Complex biliary surgery is associated with significant morbidity, prolonged hospital stay, and high cost. Clinical pathway implementation has the potential to standardize treatment and improve outcomes. Therefore the aim of this analysis was to determine whether clinical pathway implementation and\\/or feedback of outcome data would alter hospital stay, charges, and mortality rates for complex biliary surgery at an academic

  4. The Oriented Graph Complexes

    NASA Astrophysics Data System (ADS)

    Willwacher, Thomas

    2015-03-01

    The oriented graph complexes are complexes of directed graphs without directed cycles. They govern, for example, the quantization of Lie bialgebras and infinite dimensional deformation quantization. Similar to the ordinary graph complexes GC n introduced by Kontsevich they come in two essentially different versions, depending on the parity of n. It is shown that, surprisingly, the oriented graph complex is quasi-isomorphic to the ordinary commutative graph complex of opposite parity GC n-1, up to some known classes. This yields in particular a combinatorial description of the action of on Lie bialgebras, and shows that a cycle-free formality morphism in the sense of Shoikhet can be constructed rationally without reference to configuration space integrals. Curiously, the obstruction class in the oriented graph complex found by Shoikhet corresponds to the well known theta graph in the ordinary graph complex.

  5. Definitions Algebra of complex numbers

    E-print Network

    Lega, Joceline

    Definitions Algebra of complex numbers Polar coordinates form of complex numbers Check your knowledge Review of Complex Numbers Definitions, Algebra of complex numbers, Polar coordinates Review of Complex Numbers #12;Definitions Algebra of complex numbers Polar coordinates form of complex numbers Check

  6. Visual computing for medical diagnosis and treatment

    Microsoft Academic Search

    Jan Klein; Ola Friman; Markus Hadwiger; Bernhard Preim; Felix Ritter; Anna Vilanova; Gabriel Zachmann; Dirk Bartz

    2009-01-01

    Diagnostic algorithms and efficient visualization techniques are of major importance for preoperative decisions, intra-operative imaging and image-guided surgery. Complex diagnostic decisions are characterized by a high information flow and fast decisions, requiring efficient and intuitive presentation of complex medical data and precision in the visualization. For intra-operative medical treatment, the pre-operative visualization results of the diagnostic systems have to be

  7. B Plant complex treatment, storage, and disposal units inspection plan

    SciTech Connect

    Beam, T.G.

    1994-10-01

    Owners or operators of facilities that treat, store, and/or dispose of dangerous waste and/or mixed waste as defined by WAC 173-303, {open_quotes}Dangerous Waste Regulations,{close_quotes} must inspect their facilities to prevent malfunctions and deteriorations, operator errors, and discharges that may cause or lead to the release of hazardous waste constituents to the environment and/or cause a threat to human health. The WAC regulations require a written inspection schedule be developed, implemented, and kept at the facility.

  8. Exact replica treatment of non-Hermitean complex random matrices

    Microsoft Academic Search

    Eugene Kanzieper

    2003-01-01

    Recently discovered exact integrability of zero-dimensional replica field theories [E. Kanzieper, Phys. Rev. Lett. 89, 250201 (2002)] is examined in the context of Ginibre Unitary Ensemble of non-Hermitean random matrices (GinUE). In particular, various nonperturbative fermionic replica partition functions for this random matrix model are shown to belong to a positive, semi-infinite Toda Lattice Hierarchy which, upon its Painleve reduction,

  9. Hospital treatment of HIV patients.

    PubMed

    Ola, Samuel Olawale

    2006-12-01

    Treatment of patients with HIV/AIDS in Nigeria has progressed from the stage of inactivity, unconcern, abandonment and neglect to the present stage of holistic care involving treatment of the infection with Highly Active Anti Retroviral Agents, complications of the disease and side effects of antiretroviral therapy as well as that of human behavioural responses towards the disease with hope and promising outcome. The goal of the treatment is to prolong the patient's life while maintaining the best possible quality of health and life. It is now a continuum of care between the hospital and the different sectors of the community. Hospital treatment of patients with HIV-AIDS is complex and yet a simple task if there is healthy interaction of the patients and health care providers in a milieu of well equipped hospital setting with available treatment facilities for proper management of diseases. Similarly, for the care to achieve its goal, it requires a joint participation of the community and the commitment of the government not only on curtailment of the reservoir of HIV infection by antiretroviral therapy but total eradication of diseases, poverty and ignorance in all its entirety. PMID:18050774

  10. Formation of interpolymer complexes

    Microsoft Academic Search

    Eishun Tsuchida; Yoshihito Osada; Hiroyuki Ohno

    1980-01-01

    Interpolymer complex formations of poly(methacrylic acid) (PMAA) or poly(acrylic acid) (PAA) with oligocations as well as poly(ethylene oxide) (PEO), and poly-(N-vinyl-2-pyrrolidone of various chain lengths were studied. For the case of complexation between PMAA and oligocations, the standard free energy change for the complexation ?G° was found to be linearly dependent on the number of interacting sites, n. The stability

  11. The Complexity of Distributions

    Microsoft Academic Search

    Emanuele Viola

    2010-01-01

    Complexity theory typically studies the complexity of computing a function h(x) : {0, 1}m ? {0,1}n of a given input x. We advocate the study of the complexity of generating the distribution h(x) for uniform x, given random bits. Our main results are: (1) Any function f : {0, 1}? ? {0,1}n such that (i) each output bit fi depends

  12. Acute Migraine Treatment in Adults.

    PubMed

    Becker, Werner J

    2015-06-01

    There are many options for acute migraine attack treatment, but none is ideal for all patients. This study aims to review current medical office-based acute migraine therapy in adults and provides readers with an organized approach to this important facet of migraine treatment. A general literature review includes a review of several recent published guidelines. Acetaminophen, 4 nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, acetylsalicylic acid [ASA], naproxen sodium, and diclofenac potassium), and 7 triptans (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan) have good evidence for efficacy and form the core of acute migraine treatment. NSAID-triptan combinations, dihydroergotamine, non-opioid combination analgesics (acetaminophen, ASA, and caffeine), and several anti-emetics (metoclopramide, domperidone, and prochlorperazine) are additional evidence-based options. Opioid containing combination analgesics may be helpful in specific patients, but should not be used routinely. Clinical features to be considered when choosing an acute migraine medication include usual headache intensity, usual rapidity of pain intensity increase, nausea, vomiting, degree of disability, patient response to previously used medications, history of headache recurrence with previous attacks, and the presence of contraindications to specific acute medications. Available acute medications can be organized into 4 treatment strategies, including a strategy for attacks of mild to moderate severity (strategy one: acetaminophen and/or NSAIDs), a triptan strategy for patients with severe attacks and for attacks not responding to strategy one, a refractory attack strategy, and a strategy for patients with contraindications to vasoconstricting drugs. Acute treatment of migraine attacks during pregnancy, lactation, and for patients with chronic migraine is also discussed. In chronic migraine, it is particularly important that medication overuse is eliminated or avoided. Migraine treatment is complex, and treatment must be individualized and tailored to the patient's clinical features. Clinicians should make full use of available medications and formulations in an organized approach. PMID:25877672

  13. Underground Coal Thermal Treatment

    SciTech Connect

    P. Smith; M. Deo; E. Eddings; A. Sarofim; K. Gueishen; M. Hradisky; K. Kelly; P. Mandalaparty; H. Zhang

    2011-10-30

    The long-term objective of this work is to develop a transformational energy production technology by insitu thermal treatment of a coal seam for the production of substitute natural gas (SNG) while leaving much of the coalâ??s carbon in the ground. This process converts coal to a high-efficiency, low-GHG emitting gas fuel. It holds the potential of providing environmentally acceptable access to previously unusable coal resources. This topical report discusses the development of experimental capabilities, the collection of available data, and the development of simulation tools to obtain process thermo-chemical and geo-thermal parameters in preparation for the eventual demonstration in a coal seam. It also includes experimental and modeling studies of CO{sub 2} sequestration. Efforts focused on: â?˘ Constructing a suite of three different coal pyrolysis reactors. These reactors offer the ability to gather heat transfer, mass transfer and kinetic data during coal pyrolysis under conditions that mimic in situ conditions (Subtask 6.1). â?˘ Studying the operational parameters for various underground thermal treatment processes for oil shale and coal and completing a design matrix analysis for the underground coal thermal treatment (UCTT). This analysis yielded recommendations for terms of targeted coal rank, well orientation, rubblization, presence of oxygen, temperature, pressure, and heating sources (Subtask 6.2). â?˘ Developing capabilities for simulating UCTT, including modifying the geometry as well as the solution algorithm to achieve long simulation times in a rubblized coal bed by resolving the convective channels occurring in the representative domain (Subtask 6.3). â?˘ Studying the reactive behavior of carbon dioxide (CO{sub 2}) with limestone, sandstone, arkose (a more complex sandstone) and peridotite, including mineralogical changes and brine chemistry for the different initial rock compositions (Subtask 6.4). Arkose exhibited the highest tendency of participating in mineral reactions, which can be attributed to the geochemical complexity of its initial mineral assemblage. In experiments with limestone, continuous dissolution was observed with the release of CO{sub 2} gas, indicated by the increasing pressure in the reactor (formation of a gas chamber). This occurred due to the lack of any source of alkali to buffer the solution. Arkose has the geochemical complexity for permanent sequestration of CO{sub 2} as carbonates and is also relatively abundant. The effect of including NH{sub 3} in the injected gas stream was also investigated in this study. Precipitation of calcite and trace amounts of ammonium zeolites was observed. A batch geochemical model was developed using Geochemists Workbench (GWB). Degassing effect in the experiments was corrected using the sliding fugacity model in GWB. Experimental and simulation results were compared and a reasonable agreement between the two was observed.

  14. Psychosocial Treatment for Schizophrenia

    Microsoft Academic Search

    Alan S. Bellack; Kim T. Mueser

    1993-01-01

    This article addresses issues affecting the progress of research on the psychological treatment of schizophrenia, including the need for comprehensive and long-term treatment, individual differences in treatment needs, the role of the patient in the treatment process, and the limitations imposed by information-processing deficits. Despite these issues, research on psychological treatment has made significant progress over the last decade. Controlled

  15. Use of a Coupled Biological System to Treat a Chemically Complex Air Stream

    Microsoft Academic Search

    M. R. Manninen; B. A. Niemi; G. T. Kleinheinz

    2003-01-01

    The use of biological systems to remove contaminants from waste streams has been well documented. However, when dealing with complex waste streams, the use of one biological treatment system may not be the best alternative. When treating a complex waste stream, the use of “treatment trains” or “coupled systems” may be advantageous compared with any single biological technology. This article

  16. OPTIMIZING THE SCENARIO POSITIONS FOR ROBUST RADIATION THERAPY TREATMENT PLANNING

    E-print Network

    Forsgren, Anders

    OPTIMIZING THE SCENARIO POSITIONS FOR ROBUST RADIATION THERAPY TREATMENT PLANNING Albin FREDRIKSSON Royal Institute of Technology October 10, 2012 Abstract Complex external beam radiation therapy scenario positions. 1. Introduction In external beam radiation therapy, misalignment of the patient

  17. The complexity gap

    Microsoft Academic Search

    L. B. S. Raccoon

    1995-01-01

    The Complexity Gap defines a new way to think about software development. We have all heard that developers need to be more productive and to work harder. But what does this mean exactly? The Complexity Gap defines a structure in which to explore concepts of process and productivity and to show how these concepts relate to conventional software development issues

  18. North Campus Recreation Complex

    E-print Network

    North Carolina at Chapel Hill, University of

    Recreation Complex Kenan Stadium Field Bryson Field Hooker Fields Fetzer Field Henry Stadium Field Navy Field Navy Field Ehringhaus Field South Campus Recreation Complex Sciences Peabody Craige Center Jones Graham Phillips F Teague South NC Women's and Children's Education Center Taylor Undergrad Steam

  19. Complex systems: Network thinking

    Microsoft Academic Search

    Melanie Mitchell

    2006-01-01

    Like arti?cial intelligence in its earlier years, the ?eld of complex systems has received a lot of press in the last two decades, both positive and negative, breezily hyped and unjustly derogatory. As in the early years of AI, complex systems scientists have at times made promises and set up expectations that are hard for any young science to ful?ll.

  20. Einstein's Light Complex

    Microsoft Academic Search

    Dragan Redzic; Janez Strnad

    2004-01-01

    The light complex introduced by A. Einstein in his first relativity paper has the characteristics of a provisional concept and was soon abandoned. Nevertheless, it was crucial for Einstein's derivation of the equivalence of mass and energy. The discussion of various forms of the light complex strictly within Maxwell's electrodynamics leads to interesting insight.

  1. Performance Improvement Assuming Complexity

    ERIC Educational Resources Information Center

    Rowland, Gordon

    2007-01-01

    Individual performers, work teams, and organizations may be considered complex adaptive systems, while most current human performance technologies appear to assume simple determinism. This article explores the apparent mismatch and speculates on future efforts to enhance performance if complexity rather than simplicity is assumed. Included are…

  2. INFORMATIONSOURCES KSC Visitor Complex

    E-print Network

    Waliser, Duane E.

    INFORMATIONSOURCES KSC Visitor Complex The Kennedy Space Center Visitor Complex will be streaming Theatres. Entrance fees will apply (excluding KSC badged and NASA employees). Be advised that attendance it will be recovered by NASA and U.S. Navy teams. SP-2014-11-356-KSC #12;

  3. Complex Adaptive Systems

    Microsoft Academic Search

    JASON BROWNLEE

    The field of Complex Adaptive Systems (CAS) is approximately 20 years old, having been established by physicists, economists, and others studying complexity at the Santa Fe Institute in New Mexico, USA. The field has spawned much work, such as Holland's contributions of genetic algorithms, classifier systems, and his ecosystem simulator, which assisted in provoking the fields of evolutionary computation and

  4. Complex systems and valuation

    Microsoft Academic Search

    Karin E. Limburg; Robert V. O'neill; Robert Costanza; Stephen Farber

    2002-01-01

    Ecological and economic systems are undeniably complex. Whereas a goal of delineating ‘ecosystem services’ is to make readily apparent some of the important ways in which ecosystems underpin human welfare, insights are also gained by appreciating the nonlinear dynamic properties of ecosystems. In this paper, we review some of the relevant characteristics of complex systems. Ecosystems and economic systems share

  5. Visual Complexity: A Review

    ERIC Educational Resources Information Center

    Donderi, Don C.

    2006-01-01

    The idea of visual complexity, the history of its measurement, and its implications for behavior are reviewed, starting with structuralism and Gestalt psychology at the beginning of the 20th century and ending with visual complexity theory, perceptual learning theory, and neural circuit theory at the beginning of the 21st. Evidence is drawn from…

  6. U1A Complex

    ScienceCinema

    None

    2015-01-09

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  7. Complexity in Picture Books

    ERIC Educational Resources Information Center

    Sierschynski, Jarek; Louie, Belinda; Pughe, Bronwyn

    2015-01-01

    One of the key requirements of Common Core State Standards (CCSS) in English Language Arts is that students are able to read and access complex texts across all grade levels. The CCSS authors emphasize both the limitations and lack of accuracy in the current CCSS model of text complexity, calling for the development of new frameworks. In response…

  8. Ankle Sprain Treatment

    MedlinePLUS

    ... Issues Listen Espańol Text Size Email Print Share Ankle Sprain Treatment Article Body Acute ankle and foot injuries are common in athletes and ... Pediatrics summarizing the treatment phases of rehabilitation for ankle sprain. Phase Summary Description I Phase I treatment ...

  9. Treatment of acute gout.

    PubMed

    Schlesinger, Naomi

    2014-05-01

    This article presents an overview of the treatment of acute gout. Nonpharmacologic and pharmacologic treatments, monotherapy versus combination therapy, suggested recommendations, guidelines for treatment, and drugs under development are discussed. PMID:24703350

  10. ICDF Complex Remedial Action Report

    SciTech Connect

    W. M. Heileson

    2007-09-26

    This Idaho CERCLA Disposal Facility (ICDF) Remedial Action Report has been prepared in accordance with the requirements of Section 6.2 of the INEEL CERCLA Disposal Facility Remedial Action Work Plan. The agency prefinal inspection of the ICDF Staging, Storage, Sizing, and Treatment Facility (SSSTF) was completed in June of 2005. Accordingly, this report has been developed to describe the construction activities completed at the ICDF along with a description of any modifications to the design originally approved for the facility. In addition, this report provides a summary of the major documents prepared for the design and construction of the ICDF, a discussion of relevant requirements and remedial action objectives, the total costs associated with the development and operation of the facility to date, and identification of necessary changes to the Agency-approved INEEL CERCLA Disposal Facility Remedial Action Work Plan and the ICDF Complex Operations and Maintenance Plan.

  11. Complexity and behavioral economics.

    PubMed

    Rosser, J Barkley; Rosser, Marina V

    2015-04-01

    This paper will consider the relationship between complexity economics and behavioral economics. A crucial key to this is to understand that Herbert Simon was both the founder of explicitly modern behavioral economics as well as one of the early developers of complexity theory. Bounded rationality was essentially derived from Simon's view of the impossibility of full rationality on the part of economic agents. Modern complexity theory through such approaches as agent-based modeling offers an approach to understanding behavioral economics by allowing for specific behavioral responses to be assigned to agents who interact within this context, even without full rationality. Other parts of modern complexity theory are considered in terms of their relationships with behavioral economics. Fundamentally, complexity provides an ultimate foundation for bounded rationality and hence the need to use behavioral economics in a broader array of contexts than most economists have thought appropriate. PMID:25783044

  12. Effective Treatment for Addicted Criminal Justice Clients

    Microsoft Academic Search

    Harvey Weiner; Arlin Silberman; Peter Glowacki; W. Charles Folks

    1997-01-01

    Addicted criminal justice clients present unique challenges because of the complex biopsychosocial problems which frequently accompany their addiction. An overview of the current understanding of addictive disease is presented, including the important distinction between abstinence and sobriety.In the Eagleville Recovery Program, each client's medical, psy-chosocial, educational, vocational and psychiatric assessments arc used to develop an individualized treatment plan. Group therapy

  13. Water Treatment Process

    NSDL National Science Digital Library

    In this activity students can follow a drop of water from the source through the treatment process. Stop at each treatment point and unscramble the words to show where the water is along the treatment path. Click on each treatment point on the image to view the unscrambled answer and a little information about that treatment point. The treatment points are: coagulation, sedimentation, filtration, disinfection, and storage.

  14. Monitoring treatment and managing adherence in schizophrenia.

    PubMed

    Marder, Stephen R

    2013-10-01

    The majority of patients with schizophrenia will be nonadherent at some point during their treatment, which is why clinicians must assess adherence at each visit and promptly address any barriers. Treatment adherence can be negatively impacted by substance use, cognitive impairment, complex treatment regimens, and antipsychotic-induced adverse effects. Clinicians must monitor these risk factors, particularly metabolic, neurologic, and other side effects, not only to improve adherence but also to protect patients from dangerous health conditions. Interventions that can address some barriers to treatment adherence include adjusting medications as necessary, implementing lifestyle changes, using long-acting injectable antipsychotics, educating patients and their families, and implementing psychosocial therapy. With the appropriate interventions and support, patients with schizophrenia can maintain their treatment regimens and avoid relapse. PMID:24229761

  15. Characterization and electrochemical treatment of landfill leachate.

    PubMed

    Orescanin, Visnja; Kollar, Robert; Ruk, Damir; Nad, Karlo

    2012-01-01

    A combined treatment approach using advanced oxidation, electrochemical methods and microwaves was developed and applied for the treatment of landfill leachate taken from Piskornica (Koprivnica, Croatia) sanitary landfill. Due to the complex nature of the effluent and extremely low bio-degradability (BOD(5)/COD ratio = 0.01) the purification of the leachate started with pre-treatment with ozone followed by simultaneous ozonation and electrocoagulation/electrooxidation using the set of iron and aluminum electrodes, and finally, the degradation of organic residue and ammonia with microwaves. Applied treatment approach resulted in clear, colorless and odorless effluent with the values of all measured parameters significantly lower compared to the upper permissible limit for discharge into the environment. The removal percentages of the parameters: color, turbidity, suspended solids, ammonia, COD and iron following the combined treatment were 98.43%, 99.48%, 98.96%, 98.80%, 94.17% and 98.56%, respectively. PMID:22320699

  16. The Trimeric Model: A New Model of Periodontal Treatment Planning

    PubMed Central

    Tarakji, Bassel

    2014-01-01

    Treatment of periodontal disease is a complex and multidisciplinary procedure, requiring periodontal, surgical, restorative, and orthodontic treatment modalities. Several authors attempted to formulate models for periodontal treatment that orders the treatment steps in a logical and easy to remember manner. In this article, we discuss two models of periodontal treatment planning from two of the most well-known textbook in the specialty of periodontics internationally. Then modify them to arrive at a new model of periodontal treatment planning, The Trimeric Model. Adding restorative and orthodontic interrelationships with periodontal treatment allows us to expand this model into the Extended Trimeric Model of periodontal treatment planning. These models will provide a logical framework and a clear order of the treatment of periodontal disease for general practitioners and periodontists alike. PMID:25177662

  17. Geoengineering treatment of methane

    NASA Astrophysics Data System (ADS)

    Lockley, Andrew; Gardian, Alan

    2010-05-01

    Methane is a significant GHG, and substantial reservoirs are vulnerable to instability due to AGW. Excursions, from permafrost and clathrates especially, act a positive feedback to AGW. Existing concentrations of well-mixed atmospheric methane substantially exceed pre-industrial levels. Various geoengineering methods are herein proposed for containment of methane, and/or accelerated oxidation to CO2 (a gas with a lower GWP over all timescales). A basic qualitative analysis of each technique is undertaken, to direct further study. Consideration is also given to the potential capacity of each technique to treat the total likely excursions of methane expected as a result of AGW. Proposed techniques: Section 0 SRM (comparison option) Section 1 Pre-emptive treatment of methane reservoirs Soil heating (polytunnels, heat pumps); Soil aeration; Mining of clathrates; Burning of clathrates Section 2 Remediation of aquatic methane excursions Lake sealing; Mixing of aquatic strata; Bubble capture; Lake aeration; Biological oxidation in aquatic environments Section 3 Remediation of concentrated atmospheric methane Regenerative thermal oxidation; Electrical ignition; Thermal ignition; Using incendiary munitions Section 4 Remediation of diffuse atmospheric methane Thermal oxidation by concentrated solar power; Compression ignition; Chemical degradation Assessment criteria: Infrastructure/implementation cost; Energy cost; Expected efficacy; Complexity/development path; Environmental impacts; Potential for CCS

  18. Collagen-DNA complex.

    PubMed

    Svintradze, David V; Mrevlishvili, George M; Metreveli, Nunu; Jariashvili, Ketevan; Namicheishvili, Luisa; Skopinska, Joana; Sionkowska, Alina

    2008-01-01

    Previously presented models of collagen-DNA (7) and collagen-siRNA (8) complexes point to a general description of delivery systems and indicate to what specific topology that system should be equipped with to effectively deliver the gene into the living body via in vivo and in vitro injection. We focused our interest on the nature of collagen-DNA complex structure and the molecular and environmental determinants of the self-association processes of collagen with the presence of DNA. In this aspect, the self-association of collagen-DNA complex offers an opportunity to characterize a unique system, which may be related to the general mechanisms of self-association of fiber macromolecules by water bridges. For characterizing the collagen-DNA interaction, we used FTIR-ATR, NMR, and AFM experiments done on a separate collagen film, DNA film, and on the peptide-DNA aqueous solution. We demonstrate that collagen-DNA spontaneously forms self-assembling complex systems in aqueous solution. Such self-association of the complex could be induced by electrostatic interactions between neutral collagen cylinders, having strong dipole moment, and negatively charged DNA cylinders. A final complex could be formed by hydrogen bonds between specified donor groups of collagen and phosphate acceptor groups of DNA. According to FTIR measurements, a collagen triple helix should not change global conformation during collagen-DNA complex formation. PMID:18052128

  19. Synchronization in complex dynamical networks coupled with complex chaotic system

    NASA Astrophysics Data System (ADS)

    Wei, Qiang; Xie, Cheng-Jun; Wang, Bo

    2015-11-01

    This paper investigates synchronization in complex dynamical networks with time delay and perturbation. The node of complex dynamical networks is composed of complex chaotic system. A complex feedback controller is designed to realize different component of complex state variable synchronize up to different scaling complex function when complex dynamical networks realize synchronization. The synchronization scaling function is changed from real field to complex field. Synchronization in complex dynamical networks with constant delay and time-varying coupling delay are investigated, respectively. Numerical simulations show the effectiveness of the proposed method.

  20. Selenophene transition metal complexes

    SciTech Connect

    White, C.J.

    1994-07-27

    This research shows that selenophene transition metal complexes have a chemistry that is similar to their thiophene analogs. Selenophene coordination has been demonstrated and confirmed by molecular structure in both the {eta}{sup 5}- and the {eta}{sup 1}(Se)-coordination modes. The reaction chemistry of selenophene complexes closely resembles that of the analogous thiophene complexes. One major difference, however, is that selenophene is a better donor ligand than thiophene making the selenophene complexes more stable than the corresponding thiophene complexes. The {sup 77}Se NMR chemical shift values for selenophene complexes fall within distinct regions primarily depending on the coordination mode of the selenophene ligand. In the final paper, the C-H bond activation of {eta}{sup 1}(S)-bound thiophenes, {eta}{sup 1}(S)-benzothiophene and {eta}{sup 1}(Se)-bound selenophenes has been demonstrated. The deprotonation and rearrangement of the {eta}{sup 1}(E)-bound ligand to the carbon bound L-yl complex readily occurs in the presence of base. Reprotonation with a strong acid gives a carbene complex that is unreactive towards nucleophilic attack at the carbene carbon and is stable towards exposure to air. The molecular structure of [Cp(NO)(PPh{sub 3})Re(2-benzothioenylcarbene)]O{sub 3}SCF{sub 3} was determined and contains a Re-C bond with substantial double bond character. Methyl substitution for the thienylcarbene or selenylcarbene gives a carbene that rearranges thermally to give back the {eta}{sup 1}(E)-bound complex. Based on these model reactions, a new mechanism for the H/D exchange of thiophene over the hydrodesulfurization catalyst has been proposed.

  1. Treatment Option Overview (Oropharyngeal Cancer)

    MedlinePLUS

    ... Cancer Treatment Paranasal Sinus & Nasal Cavity Cancer Treatment Salivary Gland Cancer Treatment Oral Cancer Prevention Oral Cancer ... Cancer Treatment Paranasal Sinus & Nasal Cavity Cancer Treatment Salivary Gland Cancer Treatment Oral Cancer Prevention Oral Cancer ...

  2. Process waste treatment system upgrades: Clarifier startup at the nonradiological wastewater treatment plant

    SciTech Connect

    Lucero, A.J.; McTaggart, D.R.; Van Essen, D.C.; Kent, T.E.; West, G.D.; Taylor, P.A.

    1998-07-01

    The Waste Management Operations Division at Oak Ridge National Laboratory recently modified the design of a reactor/clarifier at the Nonradiological Wastewater Treatment Plant, which is now referred to as the Process Waste Treatment Complex--Building 3608, to replace the sludge-blanket softener/clarifier at the Process Waste Treatment Plant, now referred to as the Process Waste Treatment Complex-Building 3544 (PWTC-3544). This work was conducted because periodic hydraulic overloads caused poor water-softening performance in the PWTC-3544 softener, which was detrimental to the performance and operating costs of downstream ion-exchange operations. Over a 2-month time frame, the modified reactor/clarifier was tested with nonradiological wastewater and then with radioactive wastewater to optimize softening performance. Based on performance to date, the new system has operated more effectively than the former one, with reduced employee radiological exposure, less downtime, lower costs, and improved effluent quality.

  3. Honors problem 1: Complex numbers. Arithmetic of complex numbers

    E-print Network

    Leininger, Christopher J.

    Honors problem 1: Complex numbers. Arithmetic of complex numbers Recall that the complex numbers identify the complex numbers with the set of linear polynomials with real coefficients). The numbers as a subset of the complex numbers by identifying the real number a with a+0i. The imaginary numbers

  4. Honors problem 1: Complex numbers. Arithmetic of complex numbers

    E-print Network

    Leininger, Christopher J.

    Honors problem 1: Complex numbers. Arithmetic of complex numbers Recall that the complex numbers we can identify the complex numbers with the set of linear polynomials with real coefficients as a subset of the complex numbers by identifying the real number a with a + 0i. The imaginary numbers

  5. Prospects for Geometric Complexity Theory Prospects for Geometric Complexity Theory

    E-print Network

    Bürgisser, Peter

    Prospects for Geometric Complexity Theory Prospects for Geometric Complexity Theory Peter B¨urgisser University of Paderborn 27th IEEE Conference on Computational Complexity Porto, June 28, 2012 #12;Prospects for Geometric Complexity Theory Two major problems Two major problems #12;Prospects for Geometric Complexity

  6. Complex formation between a nanoparticle and a weak polyelectrolyte chain: Monte Carlo simulations

    Microsoft Academic Search

    Serge Ulrich; Abohachem Laguecir; Serge Stoll

    2004-01-01

    Understanding the complexation processes between nanoparticles and polyelectrolytes is an essential aspect in many branches of nanotechnology, nanoscience, chemistry, and biology to describe processes such as nanoparticle stabilization\\/destabilization and dispersion, water treatment, microencapsulation, complexation with biomolecules for example, and evolution of the interface of many natural and synthetic systems. In view of the complexity of such processes, applications are often

  7. Toward In Vivo Disease Diagnosis and Treatment Using DNA

    Microsoft Academic Search

    Yuriy Brun; Manoj Gopalkrishnan

    2006-01-01

    We propose a technique to diagnose and treat individual cells in the human body. A virus-like system delivers a copy of a diagnosis and treatment DNA complex to each cell. The complex determines whether the cell has a specific disease based on the presence or absence of indicator mRNA molecules and, if the diagnosis is positive, releases a proper drug

  8. Children's right to treatment

    Microsoft Academic Search

    Gary B. Melton

    1978-01-01

    The courts have thus far narrowly defined the “right to treatment”; on due process grounds. However, a criterion of “protection from harm”; may form the basis of a broader right to treatment. On this basis, one may argue that the state should provide adequate treatment to children and that parents should not be able to prevent a minor's seeking treatment

  9. Pigment-protein complexes

    SciTech Connect

    Siegelman, H W

    1980-01-01

    The photosynthetically-active pigment protein complexes of procaryotes and eucaryotes include chlorophyll proteins, carotenochlorophyll proteins, and biliproteins. They are either integral components or attached to photosynthetic membranes. Detergents are frequently required to solubilize the pigment-protein complexes. The membrane localization and detergent solubilization strongly suggest that the pigment-protein complexes are bound to the membranes by hydrophobic interactions. Hydrophobic interactions of proteins are characterized by an increase in entropy. Their bonding energy is directly related to temperature and ionic strength. Hydrophobic-interaction chromatography, a relatively new separation procedure, can furnish an important method for the purification of pigment-protein complexes. Phycobilisome purification and properties provide an example of the need to maintain hydrophobic interactions to preserve structure and function.

  10. Complex System Classification

    E-print Network

    Magee, Christopher

    2004-07-24

    The use of terms such as “Engineering Systems”, “System of systems” and others have been coming into greater use over the past decade to denote systems of importance but with implied higher complexity than for the term ...

  11. Managing complexity (Advanced Perl)

    E-print Network

    Casavant, Tom

    Managing complexity (Advanced Perl) Using perl for specific tasks with help from Bioperl and CGI ­ And it was all free #12;Sources of modules/Information · www.CPAN.org · www.bioperl.org · www.perl.com · www

  12. Managing complexity (Advanced Perl)

    E-print Network

    Casavant, Tom

    1 Managing complexity (Advanced Perl) Using perl for specific tasks with help from Bioperl and CGI/Information · www.CPAN.org · www.bioperl.org · www.perl.com · www.cetus-links.org/oo_infos.html Howto: Making

  13. Carbene complexes in catalysis

    NASA Astrophysics Data System (ADS)

    Moiseev, Ilya I.

    1989-07-01

    The methods for forming carbene complexes in catalysis are analysed in the case of the catalytic conversions of hydrocarbons, acids, carbonyl compounds, carbon monoxide, and methanol. The bibliography includes 85 references.

  14. Observability of complex systems

    E-print Network

    Liu, Yang-Yu

    A quantitative description of a complex system is inherently limited by our ability to estimate the system’s internal state from experimentally accessible outputs. Although the simultaneous measurement of all internal ...

  15. Cytarabine Lipid Complex Injection

    MedlinePLUS

    ... type of cancer in the covering of the spinal cord and brain). Cytarabine lipid complex is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

  16. Volatile einsteinium hexafluoroacetylacetonate complexes

    Microsoft Academic Search

    E. V. Fedoseev; M. I. Aizenberg; S. S. Travnikov; A. V. Davydov; B. F. Myasoedov

    1987-01-01

    Volatile einsteinium hexafluoroacetylacetonate complexes have been syntehsized. Their sublimation and thermochromatographic behaviour has been studied in the presence of -diketone vapours. Interaction of einsteinium di-and trichloride with hexafluoracetylacetone vapours is discussed.

  17. Flow of complex suspensionsa)

    NASA Astrophysics Data System (ADS)

    Lindner, Anke

    2014-10-01

    The flow of complex suspensions is ubiquitous in nature and industrial applications. These suspensions are made of complex particles (anisotropic, deformable, or active) suspended in simple fluids. The macroscopic non-Newtonian properties of these suspensions depend on the nature of the suspended particles and their interaction with given flows. Here, we describe how one can make use of novel micro-fabrication techniques and microfluidic rheometers to determine their flow properties under well controlled experimental conditions. We discuss three different aspects important for the study of the flow of complex suspensions. First, we use a well known complex fluid to design a novel microfluidic rheometer. Then we measure the non-Newtonian shear viscosity of a dilute suspension of microswimmers adapting an existing microfluidic rheometer. And finally we use a micro-fabrication technique to produce well controlled model fibers inside microfluidic channels and give some examples of the flow dynamics when these model fiber suspensions are forced through constrictions.

  18. Complex Line Integrals I

    NSDL National Science Digital Library

    Moore, Lang

    Created by Lang More of the Connected Curriculum Project, the purpose of this module is to investigate the behavior of complex line integrals. This is one lesson within a much larger set of learning modules hosted by Duke University.

  19. Reconstruction Using Witness Complexes

    PubMed Central

    Oudot, Steve Y.

    2010-01-01

    We present a novel reconstruction algorithm that, given an input point set sampled from an object S, builds a one-parameter family of complexes that approximate S at different scales. At a high level, our method is very similar in spirit to Chew’s surface meshing algorithm, with one notable difference though: the restricted Delaunay triangulation is replaced by the witness complex, which makes our algorithm applicable in any metric space. To prove its correctness on curves and surfaces, we highlight the relationship between the witness complex and the restricted Delaunay triangulation in 2d and in 3d. Specifically, we prove that both complexes are equal in 2d and closely related in 3d, under some mild sampling assumptions. PMID:21643440

  20. Proteins and Complexity

    NASA Astrophysics Data System (ADS)

    Murray, Joelle; Gibbon, Dana; Runyon, Alissa; Bajracharya, Arun

    2015-03-01

    A protein's tertiary structure determines its function in living organisms. The different functions proteins serve necessitate variety in native structures. How is variation in tertiary structure created from a common set of amino acids and molecular forces? In other words, what generates complexity in structures across all types of native proteins? To explore this question, a simple HP model of protein folding was explored for evidence of self-organized criticality, a potential generator of complexity.

  1. Complex Numbers and Trigonometry

    NSDL National Science Digital Library

    Alexanderson, Gerald L.

    Complex numbers have applications in many applied sciences. This online text begins with an introduction to trigonometry, which serves as a starting point for additional discussion about complex numbers (also known as imaginary numbers). The drawings and figures are the only notable downside to this excellent resource, because many of them are somewhat crude; however, they are still fairly easy to follow. The book can be read online or downloaded for offline viewing.

  2. Complex/Symplectic Mirrors

    SciTech Connect

    Chuang, Wu-yen; Kachru, Shamit; /Stanford U., ITP /SLAC; Tomasiello, Alessandro; /Stanford U., ITP

    2005-10-28

    We construct a class of symplectic non-Kaehler and complex non-Kaehler string theory vacua, extending and providing evidence for an earlier suggestion by Polchinski and Strominger. The class admits a mirror pairing by construction. Comparing hints from a variety of sources, including ten-dimensional supergravity and KK reduction on SU(3)-structure manifolds, suggests a picture in which string theory extends Reid's fantasy to connect classes of both complex non-Kaehler and symplectic non-Kaehler manifolds.

  3. STRUCTURAL BIOLOGY: Complex II Is Complex Too

    NSDL National Science Digital Library

    Lars Hederstedt (Lund University; Department of Cell and Organism Biology)

    2003-01-31

    Access to the article is free, however registration and sign-in are required. In aerobic eukaryotic cells, the respiratory chain of enzymes in the inner mitochondrial membrane transfers electrons from NADH and succinate to molecular oxygen, in the process producing the energy-rich molecule ATP. Hederstedt explains in his Perspective that the crystal structure of bacterial SQR (equivalent to mitochondrial complex II) reveals how the arrangement of redox centers in this enzyme enables electrons to be transferred to ubiquinone while minimizing production of reactive oxygen species that could damage tissues (Yankovskaya et al.).

  4. Treatment of a Gastric Lactobezoar with N-Acetylcysteine

    PubMed Central

    2014-01-01

    Lactobezoars are a rare finding with potentially serious sequelae in pediatric patients with feeding intolerance. Aggressive treatment may be preferred to traditional treatments to avoid complications in medically complex patients. In our patient, N-acetylcysteine lavage was a safe and effective alternative that resulted in rapid resolution of his feeding intolerance. PMID:25505999

  5. Design approaches for taming complexity

    Microsoft Academic Search

    Rick Kazman; Philippe Kruchten

    2012-01-01

    We examine the essential characteristics of system complexity and simplicity and we describe a set of general design heuristics to address complexity. We distinguish inherent, irreducible complexity from perceived complexity. We illustrate a little theory of complexity with examples drawn from ultra-large-scale systems: telephony, the Internet, and the power grid. We then show how a toolkit of design approaches that

  6. Group 4 Metalloporphyrin diolato Complexes and Catalytic Application of Metalloporphyrins and Related Transition Metal Complexes

    SciTech Connect

    Guodong Du

    2004-12-19

    In this work, the first examples of group 4 metalloporphyrin 1,2-diolato complexes were synthesized through a number of strategies. In general, treatment of imido metalloporphyrin complexes, (TTP)M=NR, (M = Ti, Zr, Hf), with vicinal diols led to the formation of a series of diolato complexes. Alternatively, the chelating pinacolate complexes could be prepared by metathesis of (TTP)MCl{sub 2} (M = Ti, Hf) with disodium pinacolate. These complexes were found to undergo C-C cleavage reactions to produce organic carbonyl compounds. For titanium porphyrins, treatment of a titanium(II) alkyne adduct, (TTP)Ti({eta}{sup 2}-PhC{triple_bond}CPh), with aromatic aldehydes or aryl ketones resulted in reductive coupling of the carbonyl groups to produce the corresponding diolato complexes. Aliphatic aldehydes or ketones were not reactive towards (TTP)Ti({eta}{sup 2}-PhC{triple_bond}CPh). However, these carbonyl compounds could be incorporated into a diolato complex on reaction with a reactive precursor, (TTP)Ti[O(Ph){sub 2}C(Ph){sub 2}O] to provide unsymmetrical diolato complexes via cross coupling reactions. In addition, an enediolato complex (TTP)Ti(OCPhCPhO) was obtained from the reaction of (TTP)Ti({eta}{sup 2}-PhC{triple_bond}CPh) with benzoin. Titanium porphyrin diolato complexes were found to be intermediates in the (TTP)Ti=O-catalyzed cleavage reactions of vicinal diols, in which atmospheric oxygen was the oxidant. Furthermore, (TTP)Ti=O was capable of catalyzing the oxidation of benzyl alcohol and {alpha}-hydroxy ketones to benzaldehyde and {alpha}-diketones, respectively. Other high valent metalloporphyrin complexes also can catalyze the oxidative diol cleavage and the benzyl alcohol oxidation reactions with dioxygen. A comparison of Ti(IV) and Sn(IV) porphyrin chemistry was undertaken. While chelated diolato complexes were invariably obtained for titanium porphyrins on treatment with 1,2-diols, the reaction of vicinal diols with tin porphyrins gave a number of products, including mono-, bis-alkoxo, and chelating diolato complexes, depending on the identity of diols and the stoichiometry employed. It was also found that tin porphyrin complexes promoted the oxidative cleavage of vicinal diols and the oxidation of {alpha}-ketols to {alpha}-diketones with dioxygen. In extending the chemistry of metalloporphyrins and analogous complexes, a series of chiral tetraaza macrocyclic ligands and metal complexes were designed and synthesized. Examination of iron(II) complexes showed that they were efficient catalysts for the cyclopropanation of styrene by diazo reagents. Good yields and high diastereoselectivity were obtained with modest enantioselectivity. A rationalization of the stereoselectivity was presented on the basis of structural factors in a carbene intermediate.

  7. Updated treatment algorithm of pulmonary arterial hypertension.

    PubMed

    Galič, Nazzareno; Corris, Paul A; Frost, Adaani; Girgis, Reda E; Granton, John; Jing, Zhi Cheng; Klepetko, Walter; McGoon, Michael D; McLaughlin, Vallerie V; Preston, Ioana R; Rubin, Lewis J; Sandoval, Julio; Seeger, Werner; Keogh, Anne

    2013-12-24

    The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple and in some ways conflicting. The treatment algorithm usually includes different types of recommendations with varying degrees of scientific evidence. In addition, the algorithm is required to be comprehensive but not too complex, informative yet simple and straightforward. The type of information in the treatment algorithm are heterogeneous including clinical, hemodynamic, medical, interventional, pharmacological and regulatory recommendations. Stakeholders (or users) including physicians from various specialties and with variable expertise in PAH, nurses, patients and patients' associations, healthcare providers, regulatory agencies and industry are often interested in the PAH treatment algorithm for different reasons. These are the considerable challenges faced when proposing appropriate updates to the current evidence-based treatment algorithm.The current treatment algorithm may be divided into 3 main areas: 1) general measures, supportive therapy, referral strategy, acute vasoreactivity testing and chronic treatment with calcium channel blockers; 2) initial therapy with approved PAH drugs; and 3) clinical response to the initial therapy, combination therapy, balloon atrial septostomy, and lung transplantation. All three sections will be revisited highlighting information newly available in the past 5 years and proposing updates where appropriate. The European Society of Cardiology grades of recommendation and levels of evidence will be adopted to rank the proposed treatments. PMID:24355643

  8. Toward stratified treatments for bipolar disorders.

    PubMed

    Hasler, Gregor; Wolf, Andreas

    2015-03-01

    In bipolar disorders, there are unclear diagnostic boundaries with unipolar depression and schizophrenia, inconsistency of treatment guidelines, relatively long trial-and-error phases of treatment optimization, and increasing use of complex combination therapies lacking empirical evidence. These suggest that the current definition of bipolar disorders based on clinical symptoms reflects a clinically and etiologically heterogeneous entity. Stratification of treatments for bipolar disorders based on biomarkers and improved clinical markers are greatly needed to increase the efficacy of currently available treatments and improve the chances of developing novel therapeutic approaches. This review provides a theoretical framework to identify biomarkers and summarizes the most promising markers for stratification regarding beneficial and adverse treatment effects. State and stage specifiers, neuropsychological tests, neuroimaging, and genetic and epigenetic biomarkers will be discussed with respect to their ability to predict the response to specific pharmacological and psychosocial psychotherapies for bipolar disorders. To date, the most reliable markers are derived from psychopathology and history-taking, while no biomarker has been found that reliably predicts individual treatment responses. This review underlines both the importance of clinical diagnostic skills and the need for biological research to identify markers that will allow the targeting of treatment specifically to sub-populations of bipolar patients who are more likely to benefit from a specific treatment and less likely to develop adverse reactions. PMID:25595029

  9. Treatment Binds of Drug Treatment Personnel.

    ERIC Educational Resources Information Center

    Saxon, Steve; Blaine, Jack D.

    1978-01-01

    The person directly involved in providing drug treatment services is often caught in a bind of dual or multiple loyalties to his patient and his employer, as well as to various laws and regulations. The article explores the influence of these binds upon patients, counselors, and treatment outcomes. (LPG)

  10. Six Questions on Complex Systems

    NASA Astrophysics Data System (ADS)

    Symons, John F.; Sanayei, Ali

    2011-09-01

    This paper includes an interview with John F. Symons regarding some important questions in "complex systems" and "complexity". In addition, he has stated some important open problems concerning complex systems in his research area from a philosophical point of view.

  11. Manganese 2 -Complexes as Auxiliaries

    E-print Network

    Lepore, Salvatore D.

    reaction with methylcyclopentadienyl manganese tricarbonyl. This complex readily underwent aldol reactions by Franck-Neumann demonstrating that alkynyl esters 2 -complexed to methylcyclopentadienyl manganeseManganese 2 -Complexes as Auxiliaries for Stereoselective Aldol Synthesis of Allenyl Carbinols

  12. Complex Regional Pain Syndrome

    MedlinePLUS

    ... symptoms. Other treatments may include physical therapy, sympathetic nerve block, spinal cord stimulation, and intrathecal drug pumps to deliver opioids and local anesthetic agents via the spinal cord. What is the prognosis? ...

  13. Section 5.6 Complex Numbers1 Section 5.Section 5.Section 5.Section 5.6666 Complex NumbersComplex NumbersComplex NumbersComplex Numbers

    E-print Network

    Farlow, Jerry

    Section 5.6 Complex Numbers1 Section 5.Section 5.Section 5.Section 5.6666 Complex NumbersComplex NumbersComplex NumbersComplex Numbers Purpose of SectionPurpose of SectionPurpose of SectionPurpose of Section To introduce the field ( ), ,+ ×» of complex numbers and their Cartesian

  14. Catalytic organometallic anticancer complexes

    PubMed Central

    Dougan, Sarah J.; Habtemariam, Abraha; McHale, Sarah E.; Parsons, Simon; Sadler, Peter J.

    2008-01-01

    Organometallic complexes offer chemistry that is not accessible to purely organic molecules and, hence, potentially new mechanisms of drug action. We show here that the presence of both an iodido ligand and a ?-donor/?-acceptor phenylazopyridine ligand confers remarkable inertness toward ligand substitution on the half-sandwich “piano-stool” ruthenium arene complexes [(?6-arene)Ru(azpy)I]+ (where arene = p-cymene or biphenyl, and azpy = N,N-dimethylphenyl- or hydroxyphenyl-azopyridine) in aqueous solution. Surprisingly, despite this inertness, these complexes are highly cytotoxic to human ovarian A2780 and human lung A549 cancer cells. Fluorescence-trapping experiments in A549 cells suggest that the cytotoxicity arises from an increase in reactive oxygen species. Redox activity of these azopyridine RuII complexes was confirmed by electrochemical measurements. The first one-electron reduction step (half-wave potential ?0.2 to ?0.4 V) is assignable to reduction of the azo group of the ligand. In contrast, the unbound azopyridine ligands are not readily reduced. Intriguingly the ruthenium complex acted as a catalyst in reactions with the tripeptide glutathione (?-l-Glu-l-Cys-Gly), a strong reducing agent present in cells at millimolar concentrations; millimolar amounts of glutathione were oxidized to glutathione disulfide in the presence of micromolar ruthenium concentrations. A redox cycle involving glutathione attack on the azo bond of coordinated azopyridine is proposed. Such ligand-based redox reactions provide new concepts for the design of catalytic drugs. PMID:18687892

  15. Quantum Complexity in Graphene

    NASA Astrophysics Data System (ADS)

    Baskaran, G.

    Carbon has a unique position among elements in the periodic table. It produces an allotrope, graphene, a mechanically robust two dimensional semimetal. The multifarious properties that graphene exhibits has few parallels among elemental metals. From simplicity, namely carbon atoms connected by pure sp2 bonds, a wealth of novel quantum properties emerge. In classical complex systems such as a spin glass or a finance market, several competing agents or elements are responsible for unanticipated and difficult to predict emergent properties. The complex (sic) structure of quantum mechanics is responsbile for an unanticipated set of emergent properties in graphene. We call this quantum complexity. In fact, most quantum systems, phenomena and modern quantum field theory could be viewed as examples of quantum complexity. After giving a brief introduction to the quantum complexity we focus on our own work, which indicates the breadth in the type of quantum phenomena that graphene could support. We review our theoretical suggestions of, (i) spin-1 collective mode in netural graphene, (ii) relativistic type of phenomena in crossed electric and magnetic fields, (iii) room temperature superconductivity in doped graphene and (iv) composite Fermi sea in neutral graphene in uniform magnetic field and (v) two-channel Kondo effect. Except for the relativistic type of phenomena, the rest depend in a fundamental way on a weak electron correlation that exists in the broad two-dimensional band of graphene.

  16. Controllability of Complex Networks

    NASA Astrophysics Data System (ADS)

    Liu, Yang; Slotine, Jean-Jacques; Barabasi, Albert-Laszlo

    2011-03-01

    The ultimate proof of our understanding of natural or technological systems is reflected in our ability to control them. While control theory offers mathematical tools to steer engineered systems towards a desired state, we lack a general framework to control complex self-organized systems, like the regulatory network of a cell or the Internet. Here we develop analytical tools to study the controllability of an arbitrary complex directed network, identifying the set of driver nodes whose time-dependent control can guide the system's dynamics. We apply these tools to real and model networks, finding that sparse inhomogeneous networks, which emerge in many real complex systems, are the most difficult to control. In contrast, dense and homogeneous networks can be controlled via a few driver nodes. Counterintuitively, we find that in both model and real systems the driver nodes tend to avoid the hubs. We show that the robustness of control to link failure is determined by a core percolation problem, helping us understand why many complex systems are relatively insensitive to link deletion. The developed approach offers a framework to address the controllability of an arbitrary network, representing a key step towards the eventual control of complex systems.

  17. Hydridomethyl iridium complex

    DOEpatents

    Bergman, Robert G. (P.O. Box 7141, San Francisco, CA 94120-7141); Buchanan, J. Michael (P.O. Box 7141, San Francisco, CA 94120-7141); Stryker, Jeffrey M. (P.O. Box 7141, San Francisco, CA 94120-7141); Wax, Michael J. (P.O. Box 7141, San Francisco, CA 94120-7141)

    1989-01-01

    A process for functionalizing methane comprising: (a) reacting methane with a hydridoalkyl metal complex of the formula: CpIr[P(R.sub.1).sub.3 ]H(R.sub.2) wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical having from 1 to 5 carbon atoms; Ir represents an iridium atom; P represents a phosphorus atom; R.sub.1 represents an alkyl group; R.sub.2 represents an alkyl group having at least two carbon atoms; and H represents a hydrogen atom, in the presence of a liquid alkane R.sub.3 H having at least three carbon atoms to form a hydridomethyl complex of the formula: CpIr[P(R.sub.1).sub.3 ]HMe where Me represents a methyl radical. (b) reacting said hydridomethyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas: CX'X"X'"X"" or CHX'X"X'"; wherein X', X", X"', and X"" represent halogens selected from bromine, iodine and chlorine, to halomethyl complex of step (a) having the formula: CpIr[P(R.sub.1).sub.3 ]MeX: (c) reacting said halomethyl complex with a mercuric halide of the formula HgX.sub.2 to form a methyl mercuric halide of the formula HgMeX; and (d) reacting said methyl mercuric halide with a molecular halogen of the formula X.sub.2 to form methyl halide.

  18. BAF chromatin remodeling complex

    PubMed Central

    Tuoc, Tran Cong; Narayanan, Ramanathan; Stoykova, Anastassia

    2013-01-01

    The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size. PMID:23974113

  19. The 20S Proteasome as an Assembly Platform for the 19S Regulatory Complex

    Microsoft Academic Search

    Klavs B. Hendil; Franziska Kriegenburg; Keiji Tanaka; Shigeo Murata; Anne-Marie B. Lauridsen; Anders H. Johnsen; Rasmus Hartmann-Petersen

    2009-01-01

    26S proteasomes consist of cylindrical 20S proteasomes with 19S regulatory complexes attached to the ends. Treatment with high concentrations of salt causes the regulatory complexes to separate into two sub-complexes, the base, which is in contact with the 20S proteasome, and the lid, which is the distal part of the 19S complex. Here, we describe two assembly intermediates of the

  20. Pharmacologic treatment of paraphilias.

    PubMed

    Assumpçăo, Alessandra Almeida; Garcia, Frederico Duarte; Garcia, Heloise Delavenne; Bradford, John M W; Thibaut, Florence

    2014-06-01

    The treatment of paraphilias remains a challenge in the mental health field. Combined pharmacologic and psychotherapeutic treatment is associated with better efficacy. The gold standard treatment of severe paraphilias in adult males is antiandrogen treatment with cognitive behavioral therapy. Selective serotonin reuptake inhibitors have been used in mild types of paraphilia and in cases of sexual compulsions and juvenile paraphilias. Antiandrogen treatments seem to be effective in severe paraphilic subjects committing sexual offenses. In particular, gonadotropin-releasing hormone analogs have shown high efficacy working in a similar way to physical castration but being reversible at any time. Treatment recommendations, side effects, and contraindications are discussed. PMID:24877704

  1. In pursuit of homoleptic actinide alkyl complexes.

    PubMed

    Seaman, Lani A; Walensky, Justin R; Wu, Guang; Hayton, Trevor W

    2013-04-01

    This Forum Article describes the pursuit of isolable homoleptic actinide alkyl complexes, starting with the pioneering work of Gilman during the Manhattan project. The initial reports in this area suggested that homoleptic uranium alkyls were too unstable to be isolated, but Wilkinson demonstrated that tractable uranium alkyls could be generated by purposeful "ate" complex formation, which serves to saturate the uranium coordination sphere and provide the complexes with greater kinetic stability. More recently, we reported the solid-state molecular structures of several homoleptic uranium alkyl complexes, including [Li(THF)4][U(CH2(t)Bu)5], [Li(TMEDA)]2[UMe6], [K(THF)]3[K(THF)2][U(CH2Ph)6]2, and [Li(THF)4][U(CH2SiMe3)6], by employing Wilkinson's strategy. Herein, we describe our attempts to extend this chemistry to thorium. The treatment of ThCl4(DME)2 with 5 equiv of LiCH2(t)Bu or LiCH2SiMe3 at -25 °C in THF affords [Th(CH2(t)Bu)5] (1) and [Li(DME)2][Th(CH2SiMe3)5 (2), respectively, in moderate yields. Similarly, the treatment of ThCl4(DME)2 with 6 equiv of K(CH2Ph) produces [K(THF)]2[Th(CH2Ph)6] (3), in good yield. Complexes 1-3 have been fully characterized, while the structures of 1 and 3 were confirmed by X-ray crystallography. Additionally, the electronic properties of 1 and 3 were explored by density functional theory. PMID:22716022

  2. Split-step complex Padé-Fourier depth migration

    Microsoft Academic Search

    Linbin Zhang; James W. Rector; G. Michael Hoversten; Sergey Fomel

    2007-01-01

    We present a split-step complex Padé-Fourier migration method based on the one-way wave equation. The downward-continuation operator is split into two downward-continuation operators: one operator is a phase-shift operator and the other operator is a finite-difference operator. A complex treatment of the propagation operator is applied to mitigate inaccuracies and instabilities due to evanescent waves. It produces high-quality images of

  3. Magnetic Resonance Imaging Evaluation of Complex Congenital Heart Disease

    Microsoft Academic Search

    Adam L. Dorfman; Tal Geva

    Congenital heart disease (CHD) occurs in approximately 8 of every 1000 live births, half of whom require surgical or other\\u000a forms of treatment. Complex CHD has no precise acceptable definition. For the purposes of this chapter, we define complex\\u000a CHD to include conotruncal anomalies and single-ventricle heart disease. Conotruncal anomalies refer to a group of congenital heart defects involving the

  4. CO insertion in lithiated diene-tricarbonyliron complexes.

    PubMed

    Okauchi, Tatsuo; Teshima, Takao; Sadoshima, Mitsuru; Kawakubo, Hidekazu; Kagimoto, Kouta; Sugahara, Yoko; Kitamura, Mitsuru

    2010-07-21

    Lithiated 1,3-diene-iron complexes undergo a CO insertion in the presence of trimethyl phosphite via a ferrate intermediate to give 3-formyl or 3-acetyl-1,3-diene-Fe(CO)(2)P(OMe)(3) complexes. Formylation proceeds when the reaction is quenched by a strong Brřnsted acid, whereas the ketone is obtained after the treatment with iodomethane. PMID:20526499

  5. Emergy and ecosystem complexity

    NASA Astrophysics Data System (ADS)

    Ulgiati, Sergio; Brown, Mark T.

    2009-01-01

    The question "What drives complexity?" is addressed in this paper. To answer this question, we explore the way energy and material resources of different quality flow through ecosystems and support, directly and indirectly, ecosystems growth and development. Processes of resource transformation throughout the ecosystem build order, cycle materials, generate and sustain information. Energy drives all these processes and energetic principles explain much of what is observed, including energy degradation according to the laws of thermodynamics. Emergy, a quantitative measure of the global environmental work supporting ecosystem dynamics, is used here in order to provide a deeper understanding of complexity growth and decline in ecosystems. Ecosystem complexity is discussed in this paper in relation to changes in structure, organization and functional capacity, as explained by changes in emergy, empower, and transformity.

  6. Synchronization in complex networks

    NASA Astrophysics Data System (ADS)

    Arenas, Alex; Díaz-Guilera, Albert; Kurths, Jurgen; Moreno, Yamir; Zhou, Changsong

    2008-12-01

    Synchronization processes in populations of locally interacting elements are the focus of intense research in physical, biological, chemical, technological and social systems. The many efforts devoted to understanding synchronization phenomena in natural systems now take advantage of the recent theory of complex networks. In this review, we report the advances in the comprehension of synchronization phenomena when oscillating elements are constrained to interact in a complex network topology. We also take an overview of the new emergent features coming out from the interplay between the structure and the function of the underlying patterns of connections. Extensive numerical work as well as analytical approaches to the problem are presented. Finally, we review several applications of synchronization in complex networks to different disciplines: biological systems and neuroscience, engineering and computer science, and economy and social sciences.

  7. [Prevention and treatment of hypermotive syndromes in patients needing dental care. 2. Treatment].

    PubMed

    Antenucci, F; Giannoni, M; Chimenti, C; Condň, F

    1988-01-01

    In the present review the Authors describe the most common therapeutical protocols used in the treatment of the most complex cases of hyperreactivity and various therapeutical instrumental and pharmacological tools now available for the dentist to solve problems linked to hyperemotive patients undergoing odontoiatric therapy. PMID:2908541

  8. Abstract. Geometry and Complex Numbers GEOMETRY AND COMPLEX NUMBERS

    E-print Network

    Lee, Carl

    Abstract. Geometry and Complex Numbers GEOMETRY AND COMPLEX NUMBERS JERZY DYDAK Contents 1. Introduction 2 2. Solving equations 10 3. Geometric proofs 20 Key words and phrases. Complex numbers. 1 #12-Euclidean, Projective, and Discrete' by Michael Henle (2nd edition, Prentice Hall). (2) `Complex numbers and geometry

  9. Honors question 3: Complex numbers (revisited). Arithmetic of complex numbers

    E-print Network

    Leininger, Christopher J.

    Honors question 3: Complex numbers (revisited). Arithmetic of complex numbers Recall that the complex numbers are formally defined as C = {a + bi} where a and b can be any real numbers and i is treated as a variable (so we can identify the complex numbers with the set of linear polynomials with real

  10. Circuit Complexity and Multiplicative Complexity of Boolean Functions

    E-print Network

    Circuit Complexity and Multiplicative Complexity of Boolean Functions Arist Kojevnikov1 Proving lower bounds on the circuit complexity of explicitly defined Boolean functions is one of the most,kulikov}@logic.pdmi.ras.ru Abstract. In this note, we use lower bounds on Boolean multiplicative complexity to prove lower bounds

  11. Universality classes of complexity

    NASA Astrophysics Data System (ADS)

    Saakian, David B.

    We give several criteria of complexity and define different universality classes. According to our classification, at the lowest class of complexity are random graph, Markov Models and Hidden Markov Models. At the next level is Sherrington-Kirkpatrick spin glass, connected with neuron-network models. On a higher level are critical theories, spin glass phase of Random Energy Model, percolation, self organized criticality (SOC). The top level class involves HOT design, error threshold in optimal coding, language, and, maybe, financial market. Alive systems are also related with the last class.

  12. Planning Complex Projects Automatically

    NASA Technical Reports Server (NTRS)

    Henke, Andrea L.; Stottler, Richard H.; Maher, Timothy P.

    1995-01-01

    Automated Manifest Planner (AMP) computer program applies combination of artificial-intelligence techniques to assist both expert and novice planners, reducing planning time by orders of magnitude. Gives planners flexibility to modify plans and constraints easily, without need for programming expertise. Developed specifically for planning space shuttle missions 5 to 10 years ahead, with modifications, applicable in general to planning other complex projects requiring scheduling of activities depending on other activities and/or timely allocation of resources. Adaptable to variety of complex scheduling problems in manufacturing, transportation, business, architecture, and construction.

  13. Complex matrix model duality

    E-print Network

    T. W. Brown

    2011-10-10

    The same complex matrix model calculates both tachyon scattering for the c=1 non-critical string at the self-dual radius and certain correlation functions of half-BPS operators in N=4 super-Yang-Mills. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich-Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces.

  14. Complex matrix model duality

    SciTech Connect

    Brown, T. W. [DESY, Hamburg, Theory Group, Notkestrasse, 85, D-22603 Hamburg (Germany)

    2011-04-15

    The same complex matrix model calculates both tachyon scattering for the c=1 noncritical string at the self-dual radius and certain correlation functions of operators which preserve half the supersymmetry in N=4 super-Yang-Mills theory. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich-Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces.

  15. Complex Gaussian Multiplicative Chaos

    NASA Astrophysics Data System (ADS)

    Lacoin, Hubert; Rhodes, Rémi; Vargas, Vincent

    2015-07-01

    In this article, we study complex Gaussian multiplicative chaos. More precisely, we study the renormalization theory and the limit of the exponential of a complex log-correlated Gaussian field in all dimensions (including Gaussian Free Fields in dimension 2). Our main working assumption is that the real part and the imaginary part are independent. We also discuss applications in 2 D string theory; in particular we give a rigorous mathematical definition of the so-called Tachyon fields, the conformally invariant operators in critical Liouville Quantum Gravity with a c = 1 central charge, and derive the original KPZ formula for these fields.

  16. Varicose vein - noninvasive treatment

    MedlinePLUS

    ... vein. The vein will harden and then disappear. Laser treatment can be used on the surface of the ... uses a light under the skin to guide treatment. This may be done along ... energy. During these procedures: Your doctor will puncture ...

  17. Laser Acne Treatment

    MedlinePLUS

    ... problem that sometimes requires multiple combined approaches (eg, laser treatment plus topical medications). Laser is fairly successful; however, ... the skin and pulses of light are emitted. Laser treatment is usually fairly quick for a small- to ...

  18. The Treatment of Addiction

    ERIC Educational Resources Information Center

    Chapple, P. A. L.

    1970-01-01

    Describes sociological and medical treatment appropriate to young drug experimenters and addicts. Discusses role of teachers, probation officers, school medical services, and general practitioners. Indicates necessity for long treatment period. Considers whether dependence is a disease of delinquent behavior. (AL)

  19. Antimicrobial Treatments and Efficacy

    EPA Science Inventory

    To limit exposure to indoor biological contamination a risk-management approach which employs various antimicrobial treatments can effectively control contaminants and reduce exposure. Antimicrobial treatment of biological contaminants, especially mold in buildings, it is often n...

  20. [A treatment plan as method and compass].

    PubMed

    Wind, A W; Gussekloo, J

    2015-01-01

    For elderly people with complex care needs, working with a treatment plan is a method for offering personalized, proactive, integrated care. The treatment plan works as a 'compass' because it indicates the key points to focus on in the care for the elderly person. It can take personal wishes and preferences into account, improve the person's ability to cope independently and involve family and caregivers in the process. The treatment plan provides an overview of the most important problems in all domains and of the professional caregivers involved. In this article we describe the potential opportunities and action points within working with treatment plans. Opportunities include shared decision making, paying attention to functioning and independent coping, and stimulation of care in the community. Action points include organization of care, registration, education and privacy. Drawing up a treatment plan is not an end in itself, but a working method, which takes into account the diversity of the elderly population and the complexity of care giving. PMID:26058766

  1. Water Treatment Process

    NSDL National Science Digital Library

    This interactive diagram allows the user to follow a drop of water from the source through the treatment process. Water may be treated differently in different communities depending on the quality of the water which enters the plant. Groundwater is water located under ground and typically requires less treatment than water from lakes, rivers, and streams. Users are invited to click on each treatment point on the image to see a little information about that treatment point.

  2. Abdominal Aortic Aneurysms: Treatments

    MedlinePLUS

    ... Minimally Invasive Treatments Snapshots Multimedia Multimedia Archive Abdominal Aortic Aneurysms Interventional Radiologists Treat Abdominal Aneurysms Nonsurgically Interventional radiologists ...

  3. Treatment of Pediculosis Capitis

    PubMed Central

    Verma, Prashant; Namdeo, Chaitanya

    2015-01-01

    An endeavour to delineate the salient details of the treatment of head lice infestation has been made in the present article. Treatment modalities including over the counter permethrin and pyrethrin, and prescription medicines, including malathion, lindane, benzyl alcohol, spinosad are discussed. Salient features of alternative medicine and physical treatment modalities are outlined. The problem of resistance to treatment has also been taken cognizance of. PMID:26120148

  4. Onsite Wastewater Treatment Systems: Aerobic Treatment Unit 

    E-print Network

    Lesikar, Bruce J.

    2008-10-31

    Aerobic units treat wastewater using the same process, only scaled down, as municipal wastewater treatment systems. This publication explains how aerobic units work, what their design requirements are, and how to maintain them....

  5. Onsite Wastewater Treatment Systems: Aerobic Treatment Unit

    E-print Network

    Lesikar, Bruce J.

    2008-10-31

    Aerobic units treat wastewater using the same process, only scaled down, as municipal wastewater treatment systems. This publication explains how aerobic units work, what their design requirements are, and how to maintain them....

  6. [Modern treatment of malaria].

    PubMed

    Popov, A F; Nikiforov, N D; Sergiev, V P; Sanin, B I

    2003-01-01

    Ineffectiveness of malaria treatment is in many cases explained by chloroquine resistance (CR) of plasmodia (CRP) which dominates in some regions of Africa and South-East Asia. The authors present their experience in malaria treatment obtained during many years, analyse malaria treatment by new antimalaria drugs in "non-immune" persons temporarily living in endemic regions. PMID:12934303

  7. The Treatment Philosophy Snowballs.

    ERIC Educational Resources Information Center

    Hern, Matt

    1998-01-01

    Students who respond to the ludicrous environments of schooling with behaviors and demeanor that do not fit school criteria frequently are given a medical label and drug treatment. The fact that Ritalin is given to 2.8% of all American children reflects a "treatment philosophy" in which professionals define problems and prescribe treatments for a…

  8. Seed Treatment. Manual 92.

    ERIC Educational Resources Information Center

    Missouri Univ., Columbia. Agricultural Experiment Station.

    This training manual provides information needed to meet minimum EPA standards for certification as a commercial applicator of pesticides in the seed treatment category. The text discusses pests commonly associated with seeds; seed treatment pesticides; labels; chemicals and seed treatment equipment; requirements of federal and state seed laws;…

  9. North Campus Recreation Complex

    E-print Network

    North Carolina at Chapel Hill, University of

    Recreation Complex Kenan Stadium Field Bryson Field Hooker Fields Fetzer Field Henry Stadium Field Navy Field Navy Field Ehringhaus Field Tennis Court W. Tennis Court S. Tennis Court E. South Campus Recreation Women's and Children's Health Bell Tower South Brooks Computer Science Old Well South Gardner Play

  10. Coordination Complexes of Cobalt.

    ERIC Educational Resources Information Center

    Williams, Gregory M.; And Others

    1989-01-01

    Described is an experiment involving the synthesis and spectral studies of cobalt complexes that not only give general chemistry students an introduction to inorganic synthesis but allows them to conduct a systematic study on the effect of different ligands on absorption spectra. Background information, procedures, and experimental results are…

  11. Complexity in Math

    NSDL National Science Digital Library

    Ian Byrd

    2013-01-01

    In this 7-minute video Ian Byrd offers suggestions for increasing the complexity of math problems in order to provide an appropriate challenge level for gifted students. When confronted with tasks in their Zone of Proximal Development, students are forced to develop strategies and skills that they can apply to more challenging work.

  12. COMPLEX NETWORKS Thefragilityofinterdependency

    E-print Network

    Stanley, H. Eugene

    ranging from hurricanes to large-scale power outages and terrorist attacks have shown that the most phenomenonbydevisingexperimentsaimedat tracing its network structure and geographical distribution4,5 . Viewed from this perspective, critical infra- structures are complex systems for which it is generally impossible to abstract the global

  13. Shuttle Computer Complex

    Microsoft Academic Search

    A. E. Cooper; W. T. Chow

    1975-01-01

    The Shuttle Computer Complex provides the on-board data processing capability for Space Shuttle Orbiter avionics. It performs the data processing necessary for guidance, navigation, and control; pay-load handling and management; and performance monitoring functions. It is made up of five interconnected but independent general purpose computers to satisfy the overall avionics requirements in fault tolerance, partitioning, and functional isolation. Each

  14. A Complex Issue.

    ERIC Educational Resources Information Center

    Popke, Michael

    2002-01-01

    Describes the $17-million sports complex being constructed in Topeka, Kansas to serve the city's 3 high schools and 125,000 residents. Describes how the school district successfully "pitched" a major sports project by assuaging the concerns of special-interest groups and garnering the support of skeptical taxpayers. (EV)

  15. Negotiating complex contracts

    Microsoft Academic Search

    Mark Klein; Peyman Faratin; Hiroki Sayama; Yaneer Bar-Yam

    2002-01-01

    Work to date on computational models of negotiation has focused almost exclusively on defining contracts consisting of one or a few independent issues. Many real-world contracts, by contrast, consist of multiple inter-dependent issues. This paper describes a simulated annealing based approach appropriate for negotiating such complex contracts, evaluates its efficacy, and suggests potentially promising avenues for future work.

  16. Complex Characters Made Simple

    ERIC Educational Resources Information Center

    Kettle, Sidney F. A.

    2009-01-01

    The physical significance of complex characters is explored with particular reference to the C[subscript 4] point group. While a diagrammatic representation of these characters in this group is possible, the extension to higher groups C[subscript n], n greater than 4 is left as a problem for discussion. (Contains 3 tables, 8 figures, and 1 note.)

  17. METAL COMPLEXING SILOXANE POLYMERS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Novel silicone polymers containing pendant phosphonate groups have been synthesized. A new silicone monomer, (CH3O)2CH3Si(CH2)3P=O(OCH2CH3)2 has been copolymerized with dimethyldimethoxysilane to form polymers capable of binding metal salts. The viscous liquids can complex a variety of metals, inc...

  18. Complex Event Recognition Architecture

    NASA Technical Reports Server (NTRS)

    Fitzgerald, William A.; Firby, R. James

    2009-01-01

    Complex Event Recognition Architecture (CERA) is the name of a computational architecture, and software that implements the architecture, for recognizing complex event patterns that may be spread across multiple streams of input data. One of the main components of CERA is an intuitive event pattern language that simplifies what would otherwise be the complex, difficult tasks of creating logical descriptions of combinations of temporal events and defining rules for combining information from different sources over time. In this language, recognition patterns are defined in simple, declarative statements that combine point events from given input streams with those from other streams, using conjunction, disjunction, and negation. Patterns can be built on one another recursively to describe very rich, temporally extended combinations of events. Thereafter, a run-time matching algorithm in CERA efficiently matches these patterns against input data and signals when patterns are recognized. CERA can be used to monitor complex systems and to signal operators or initiate corrective actions when anomalous conditions are recognized. CERA can be run as a stand-alone monitoring system, or it can be integrated into a larger system to automatically trigger responses to changing environments or problematic situations.

  19. Complexity Science for Simpletons

    Microsoft Academic Search

    Craig Alan Feinstein

    2005-01-01

    In this article, we shall describe some of the most interesting topics in the subject of Complexity Science for a general audience. Anyone with a solid foundation in high school mathematics (with some calculus) and an elementary understanding of computer programming will be able to follow this article. First, we shall explain the significance of the P versus N P

  20. Tutorial on Computational Complexity

    Microsoft Academic Search

    Craig A. Tovey

    2002-01-01

    Computational complexity measures how much work is required to solve different problems. It provides a useful classification tool for OR\\/MS practitioners, especially when tackling dis- crete deterministic problems. Use it to tell, in advance, whether a problem is easy or hard. Knowing this won't solve your problem, but it will help you to decide what kind of solution method is

  1. Complexity of Quantum Computers

    Microsoft Academic Search

    Sherwin Algoe; Walter Hop; Robbert Klarenbeek; Giacomo Mores; Ali Niknam; Andreas Verhoeven

    A quantum computer uses quantum mechanical phenomena to perform calculations. This method of computation may enable us to solve certain problems faster than any classical computer. In this paper, we present an introduction to the theory of quantum computers and explore the complexity of quantum computation. We show that quantum computers can effi ciently solve a few problems known to

  2. Irreducible Complexity Revisited

    Microsoft Academic Search

    William A. Dembski

    2004-01-01

    Michael Behe's concept of irreducible complexity, and in particular his use of this concept to critique Darwinism, continues to come under heavy fire from the biological community. The problem with Behe, so Darwinists inform us, is that he has created a problem where there is no problem. Far from constituting an obstacle to the Darwinian mechanism of random variation and

  3. Minimal Atomic Complexes

    Microsoft Academic Search

    A. J. Baker; J. P. May

    2002-01-01

    Hu, Kriz and May recently reexamined ideas implicit in Priddy's elegant homotopy theoretic construction of the Brown-Peterson spectrum at a prime p. They discussed May's notions of nuclear complexes and of cores of spaces, spectra, and commutative S-algebras. Their most striking conclusions, due to Hu and Kriz, were negative: cores are not unique up to equivalence, and BP is not

  4. Surface complexation modeling

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Adsorption-desorption reactions are important processes that affect the transport of contaminants in the environment. Surface complexation models are chemical models that can account for the effects of variable chemical conditions, such as pH, on adsorption reactions. These models define specific ...

  5. Launching Complex Tasks

    ERIC Educational Resources Information Center

    Jackson, Kara J.; Shahan, Emily C.; Gibbons, Lynsey K.; Cobb, Paul A.

    2012-01-01

    Mathematics lessons can take a variety of formats. In this article, the authors discuss lessons organized around complex mathematical tasks. These lessons usually unfold in three phases. First, the task is introduced to students. Second, students work on solving the task. Third, the teacher "orchestrates" a concluding whole-class discussion in…

  6. Parameterized learning complexity

    Microsoft Academic Search

    Rodney G. Downey; Patricia A. Evans; Michael R. Fellows

    1993-01-01

    We describe three applications in computational learning theory of techniques and ideas recently introduced in the study of parameterized computational complexity. (1) Using paratneterized problem reducibilities, we show that P-sized DNF (CNF) formulas can be exactly learned in time polynomial in the number of variables by extended equivalence queries if and only if the dominating sets of a graph can

  7. Complexity of Approximating the

    E-print Network

    Fomin, Fedor V.

    Complexity of Approximating the Oriented Diameter of Chordal Graphs Fedor V. Fomin,1 Marti the diameters of strongly connected orientations of G. We study algorithmic aspects of determining the oriented chordal bcu graph G, finds a strongly connected orientation of G with diameter at most one plus twice

  8. Complex Networks Mark Jelasity

    E-print Network

    Jelasity, Márk

    -trivial network ­ Other networks Social relationships, food web, chemical reactions (DNA), etc Complex self important (not only interesting) ­ WWW, Internet, food web, metabolic nets, etc Some common aspects must of network depending on its structure ­ Design and engineering need to understand emergent properties

  9. Swarm Intelligence Complex Systems

    E-print Network

    SchĂĽler, Axel

    Intelligence is a field of optimization that is inspired by the behaviour of natural swarms. The groupKeywords Phylogeny Swarm Intelligence Complex Systems Parallel Computing » Prof. Dr. Martin phylogenetic trees. The research group of Prof. Dr. Martin Middendorf develops algorithms to find the most

  10. Statistical Factors in Complexation Reactions.

    ERIC Educational Resources Information Center

    Chung, Chung-Sun

    1985-01-01

    Four cases which illustrate statistical factors in complexation reactions (where two of the reactants are monodentate ligands) are presented. Included are tables showing statistical factors for the reactions of: (1) square-planar complexes; (2) tetrahedral complexes; and (3) octahedral complexes. (JN)

  11. Software Systems as Complex Networks

    Microsoft Academic Search

    Lian Wen; Diana Kirk; R. Geoff Dromey

    2007-01-01

    As software systems become larger and more complex, in order to understand, manage and evolve these systems, we need better ways of characterizing and controlling their macroscopic properties. We suggest complex network theory may be useful for these purposes. In recent years, researchers have shown that many complex systems from different disciplines can be investigated as complex networks and most

  12. Spatial measures of software complexity

    Microsoft Academic Search

    C. R. Douce; P. J. Layzell; J. Buckley

    This paper introduces a set of simple software complexity metrics that has been in- spired by developments within cognitive psychology. Complexity measures are con- structed by analysing the distance between components of a program. The greater the distance between program fragments, the greater the resulting spatial complexity of a program. Suggestions are made as to how spatial complexity measures can

  13. Complexity in Biological Signaling Systems

    NSDL National Science Digital Library

    Gezhi Weng (Mount Sinai School of Medicine; Department of Pharmacology)

    1999-04-02

    Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.

  14. RESEARCH ARTICLE Complexity by Subtraction

    E-print Network

    McShea, Daniel W.

    the history of life. Keywords Evolution Á Complexity Á Constructive neutral evolution Á Irreducible complexity;argument from design to the problem of ``irreducible complexity.'' For example, skeptics have chargedRESEARCH ARTICLE Complexity by Subtraction Daniel W. McShea · Wim Hordijk Received: 9 January 2013

  15. Simple treatment structure 3.1 Replication of control treatments

    E-print Network

    Bailey, R. A.

    Chapter 3 Simple treatment structure 3.1 Replication of control treatments Suppose that treatment 1 is a control treatment and that treatments 2, .. ., t are new treatments which we want to compare;42 Chapter 3. Simple treatment structure In practice we have to use approximate solutions to Equation (3

  16. Quantum Query Complexities

    NASA Astrophysics Data System (ADS)

    Iwama, Kazuo

    2005-08-01

    The study of quantum query complexities for black-box functions (oracles) plays a central role for design methods of efficient quantum algorithms. We consider a general framework called the oracle identification problem (OIP) for black-box oracles and analyze the quantum query complexity. The OIP is, given a set S of M Boolean black-box oracles out of 2N ones, to determine which oracle in S is the current black-box oracle. We can exploit the information that candidates of the current oracle is restricted to S. The OIP contains several concrete problems such as the Grover search problem and the Bernstein-Vazirani problem. Our interest is in the quantum query complexity, for which we present several upper bounds. They are quite general and almost optimal: (i) The upper bound of query complexity of OIP is O( {? {N log M log N} log log M} ; ) for any S such that M = |S| > N, which is better than the obvious bound N if M < 2N / log3 N and the lower bound is ? ( {? {N log M} log { - 1} N} ; ) . Thus, the bounds are tight up to a logarithmic factor. (ii) It is O( {? N } ; ) for any S if |S| = N, which includes the upper bound for the Grover search as a special case. One can see that this bound is tight by the well-known lower bound of the Grover search problem, which needs ? ( {? N } ; ) queries by any quantum algorithms. (iii) For a wide range of oracles (|S| = N) such as random oracles and balanced oracles, the query complexity is O( /line {N/K} ) , where K is a simple parameter determined by S. This is a joint work with Andris Ambainis, Akinori Kawachi, Hiroyuki Masuda, Raymond H. Putra, and Shigeru Yamashita.

  17. Easily Adaptable Complexity Measure for Finite Time Series

    E-print Network

    Da-Guan Ke; Qin-Ye Tong

    2008-11-25

    We present a complexity measure for any finite time series. This measure has invariance under any monotonic transformation of the time series, has a degree of robustness against noise, and has the adaptability of satisfying almost all the widely accepted but conflicting criteria for complexity measurements. Surprisingly, the measure is developed from Kolmogorov complexity, which is traditionally believed to represent only randomness and to satisfy one criterion to the exclusion of the others. For familiar iterative systems, our treatment may imply a heuristic approach to transforming symbolic dynamics into permutation dynamics and vice versa.

  18. Drinking Water Treatment

    NSDL National Science Digital Library

    Matt Laposata

    This lesson provides an introduction to the treatment of drinking water to remove harmful or distasteful substances. Topics include the history of treatment and a brief listing of treatment processes. Students can examine a selection of online resources for more detailed information on modern treatment methods and potential contaminants. The lesson includes an activity in which they construct a model treatment plant and treat water that they have 'contaminated' themselves in order to observe firsthand the steps involved in purifying water for human consumption.

  19. Drug Treatment of Infertility

    PubMed Central

    Corenblum, Bernard

    1989-01-01

    Diagnosis and treatment of infertility, once a purely empirical process, can now be based on rational exclusion of alternatives. The author reviews the drug treatment of infertility, emphasizing ovulation induction. He also discusses the endocrine treatment of men, drug treatment of endometriosis, and antibiotic treatment of infections. The author recommends referral to a specialist when more invasive drugs, such as gonadotrophins or gonadotrophin-releasing hormone or analogue, are indicated, if the couple continues to be infertile, or when the physician suspects endometriosis. PMID:21249096

  20. Treatment of non-IBD anal fistula.

    PubMed

    Lundby, Lilli; Hagen, Kikke; Christensen, Peter; Buntzen, Steen; Thorlacius-Ussing, Ole; Andersen, Jens; Krupa, Marek; Qvist, Niels

    2015-05-01

    The course of the fistula tract in relation to the anal sphincter is identified by clinical examination under general anaesthesia using a fistula probe and injection of fluid into the external fistula opening. In the event of a complex fistula or in the case of fistula recurrence, this should be supplemented with an endoluminal ultrasound scan and/or an MRI scan. St. Mark's fistula chart should be used for the description. Simple fistulas are amenable to fistulotomy, whereas treatment of complex fistulas requires special expertise and management of all available treatment modalities to tailor the right operation to the individual patient. The given levels of evidence and grades of recommendations are according to the Oxford Centre for Evidence-based Medicine (www.cemb.net). PMID:26050835

  1. Simple theories of complex lattices

    NASA Astrophysics Data System (ADS)

    Peyrard, Michel

    1998-11-01

    While the theory of solitons has been very successful for continuous systems, very few nonlinear discrete lattices are amenable to an exact analytical treatment. In these “complex lattices” discreteness can be hostile to the solitons, preventing them to move due to the lack of translational invariance or even to exist as localized excitations. On the other hand, lattice discreteness can sometimes be very helpful. It can stabilize solutions that otherwise would split apart as in the discrete sine-Gordon lattice, or even allow the existence of localized oscillatory modes as exact solutions in systems where they would decay in the continuum limit. It is interesting that many of these phenomena can be understood qualitatively, and sometimes quantitatively, with very simple theories that rely on the usual concepts of linear wave propagation, resonances, linear stability of waves, for instance. There are, however, phenomena specific to discrete nonlinear lattices which allow the build up of large amplitude localized excitations, sometimes out of thermal fluctuations, which are more resistant to simple approaches and could deserve further interest because they may be relevant for various physical systems.

  2. Nuclear pore complex: novel glycoprotein constituents

    SciTech Connect

    Davis, L.I.

    1987-01-01

    The author describes the production of anti-nuclear monoclonal antibodies, and their use in identifying some of the constituents of the nuclear pore complex. Studies are described using an antibody that recognizes predominantly a 62 kD protein (p62) of rat liver nuclei. This protein remains associated with the nuclear pore complex-lamina fraction that results from treatment of nuclei with DNase, RNase and nonionic detergent. Immunofluorescence microscopy revealed a strikingly punctate pattern of nuclear rim staining. Using immunogold electron microscopy, p62 was specifically localized to the pore complex. Pulse chase analysis of labelled tissue culture cells showed that p62 is synthesized as a soluble cytoplasmic precursor. Additionally, p62 is posttranslationally modified by the addition of GlcNAc residues. These proteins have been shown to contain O-linked monosaccharidic GlcNAc residues. Pulse chase labelling of tissue culture cells with /sup 35/S-methionine indicates that most of the sugar is added within 5 min of synthesis, when p62 is soluble and cytosolic. Tunicamycin does not prevent glycosylation and the M/sub r/ of p62 is not affected by endoglycosidase H. Thus, the addition of GlcNAc appears to be carried out by a cytoplasmically disposed transferase and is clearly distinct from the N- and O-linked glycosylation pathways in the endoplasmic reticulum and Golgi complex.

  3. Treatment of the acquired immune deficiency syndrome

    Microsoft Academic Search

    Sudhir Gupta; Michael S. Gottlieb

    1986-01-01

    The acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) are sequelae of immune system injury initiated by a novel human retrovirus [human T-lymphotrophic virus strain III\\/lymphadenopathy-associated virus (HTLV III\\/LAV)]. The resulting spectrum of immune deficiency sets the stage for opportunistic infection and malignancy. In this review, we consider progress made in the treatment and prevention of AIDS and HTLV

  4. Tuberous sclerosis complex; single center experience

    PubMed Central

    Erol, ?lknur; Sava?, Tülin; ?ekerci, Sevda; Yaz?c?, Nalan; Erbay, Ay?e; Demir, ?enay; Sayg?, Semra; Alkan, Özlem

    2015-01-01

    Aim: This study was planned with the aim of retrospectively reviewing the clinical and laboratory findings and therapies of our patients diagnosed with tuberous sclerosis and redefining the patients according to the diagnostic criteria revised by the 2012 International Tuberous Sclerosis Complex Consensus Group and comparing them with the literature. Materials and Method: Twenty patients diagnosed with tuberous sclerosis complex in the Pediatric Neurology Clinic were examined retrospectively in terms of clinical findings and therapies. The diagnoses were compared again according to 1998 and 2012 criteria. Results: It was observed that the complaint at presentation was seizure in 17 of 20 patients and hypopigmented spots on the skin in 3 of 20 patients. On the initial physical examination, findings related with the disease were found in the skin in 17 of the patients, in the eye in 5, in the kidneys in 7 and in the brain with imaging in 17. No cardiac involvement was observed in the patients. Infantile spasm was observed in 7 of the patients who presented because of seizure (n=17), partial seizure was observed in 7 and multiple seizure types were observed in 3. It was found that sirolimus treatment was given to 9 of 20 patients because of different reasons, 7 of these 9 patients had epileptic seizures and sirolimus treatment had no effect on epileptic seizures. According to 2012 diagnostic criteria, no marked change occured in the diagnoses of our patients. Conclusions: It was observed that the signs and symptoms of our patients were compatible with the literature. Molecular genetic examination was planned for the patients who were being followed up because of probable tuberous sclerosis complex. It was observed that sirolimus treatment had no marked effect on the seizure frequency of our patients.

  5. A consistent modelling methodology for secondary settling tanks in wastewater treatment

    E-print Network

    Bürger, Raimund

    A consistent modelling methodology for secondary settling tanks in wastewater treatment Raimund Bu in wastewater treatment by combining classical concepts with results from applied mathematics, and partly was chosen as a case since this is one of the most complex processes in a wastewater treatment plant

  6. Overactive Bladder: Pharmacologic Treatments in the Neurogenic Population

    PubMed Central

    Kennelly, Michael J; DeVoe, William B

    2008-01-01

    Patients with neurologic disease commonly develop overactive bladder (OAB) symptoms of urgency, frequency, and/or urge incontinence. Although treatment for idiopathic OAB has been extensively studied, therapy for those individuals with neurogenic-mediated OAB has not been thoroughly evaluated. Included in the present article is a description of micturition neurophysiology and a neurourologic evaluation scheme. The pharmacologic treatment options for neurogenic OAB, mainly antimuscarinics and chemical denervation, are reviewed and important studies are discussed. Management of OAB in the neurogenic population is a complex issue with no uniform treatment strategy, and individualized treatment with first-line pharmacologic therapy is often recommended. PMID:18836537

  7. Visualizing Immune System Complexity

    NSDL National Science Digital Library

    Michael L. Dustin (New York University; Skirball Institute of Biomolecular Medicine REV)

    2009-04-14

    The European Molecular Biology Organization (EMBO) meeting "Visualizing Immune System Complexity," held in January 2009, covered multiple scales, from imaging single molecules to imaging whole animals. In addition to experimental details, there was an emphasis on modeling both for data analysis and as a predictive tool to support experimental design. Imaging technologies discussed included total internal reflection fluorescence microscopy, fluorescence correlation spectroscopy, two-photon laser scanning microscopy, and magnetic resonance imaging. The biological systems included basic aspects of adaptive and innate immunity. The type 1 diabetes model was used to illustrate how a human disease was dissected at all the scales, from single-molecule analysis of the interactions of T cell receptors with peptide-loaded major histocompatibility complexes to dynamics of immune cell infiltrates by intravital microscopy, as well as the application of imaging diagnostics in humans.

  8. Compressively sensed complex networks.

    SciTech Connect

    Dunlavy, Daniel M.; Ray, Jaideep; Pinar, Ali

    2010-07-01

    The aim of this project is to develop low dimension parametric (deterministic) models of complex networks, to use compressive sensing (CS) and multiscale analysis to do so and to exploit the structure of complex networks (some are self-similar under coarsening). CS provides a new way of sampling and reconstructing networks. The approach is based on multiresolution decomposition of the adjacency matrix and its efficient sampling. It requires preprocessing of the adjacency matrix to make it 'blocky' which is the biggest (combinatorial) algorithm challenge. Current CS reconstruction algorithm makes no use of the structure of a graph, its very general (and so not very efficient/customized). Other model-based CS techniques exist, but not yet adapted to networks. Obvious starting point for future work is to increase the efficiency of reconstruction.

  9. Stable generalized complex structures

    E-print Network

    Cavalcanti, Gil R

    2015-01-01

    A stable generalized complex structure is one that is generically symplectic but degenerates along a real codimension two submanifold, where it defines a generalized Calabi-Yau structure. We introduce a Lie algebroid which allows us to view such structures as symplectic forms. This allows us to construct new examples of stable structures, and also to define period maps for their deformations in which the background three-form flux is either fixed or not, proving the unobstructedness of both deformation problems. We then use the same tools to establish local normal forms for the degeneracy locus and for Lagrangian branes. Applying our normal forms to the four-dimensional case, we prove that any compact stable generalized complex 4-manifold has a symplectic completion, in the sense that it can be modified near its degeneracy locus to produce a compact symplectic 4-manifold.

  10. Stable generalized complex structures

    E-print Network

    Gil R. Cavalcanti; Marco Gualtieri

    2015-03-21

    A stable generalized complex structure is one that is generically symplectic but degenerates along a real codimension two submanifold, where it defines a generalized Calabi-Yau structure. We introduce a Lie algebroid which allows us to view such structures as symplectic forms. This allows us to construct new examples of stable structures, and also to define period maps for their deformations in which the background three-form flux is either fixed or not, proving the unobstructedness of both deformation problems. We then use the same tools to establish local normal forms for the degeneracy locus and for Lagrangian branes. Applying our normal forms to the four-dimensional case, we prove that any compact stable generalized complex 4-manifold has a symplectic completion, in the sense that it can be modified near its degeneracy locus to produce a compact symplectic 4-manifold.

  11. Imitation switch complexes.

    PubMed

    Mellor, J

    2006-01-01

    The imitation switch (ISWI) family of chromatin remodelling ATPases is found in organisms ranging from yeast to mammals. ISWI ATPases assemble chromatin and slide and space nucleosomes, making the chromatin template fluid and allowing appropriate regulation of events such as transcription, DNA replication, recombination and repair. The site of action of the ATPases is determined, in part by the tissue type in which the enzyme is expressed and in part by the nature of the proteins associated with the enzyme. The ISWI complexes are generally conserved in composition and function across species. Roles in gene expression and DNA replication in heterochromatin, gene activation and repression in euchromatin, and functions related to maintaining chromosome architecture are associated with different complexes. Defects in ISWI-associated proteins may be associated with neurodegenerative disease, anencephaly, William's syndrome and melanotic tumours. Finally, the mechanism by which yeast Isw Ib influences gene transcription is discussed. PMID:16568949

  12. Hemostasis and irreducible complexity.

    PubMed

    Aird, W C

    2003-02-01

    Coagulation evolved as a means to stem the loss of blood and to defend against pathogens. The complexity of the clotting cascade has been cited as evidence for the existence of divine intervention. The objective of this review is to draw on the debate between creationists and evolutionary biologists to highlight important evolutionary principles that underlie the hemostatic mechanism. I propose the following: (a) as with all biological systems, the hemostatic mechanism displays non-linear complexity; (b) the cellular response represents primary hemostasis owing to its place in the evolutionary time scale and functional importance; and (c) the rapid evolution of the hemostatic mechanism in vertebrates is testimony to the power and versatility of gene duplications and exon shuffling. PMID:12871493

  13. Solid waste management complex site development plan

    SciTech Connect

    Greager, T.M.

    1994-09-30

    The main purpose of this Solid Waste Management Complex Site Development Plan is to optimize the location of future solid waste treatment and storage facilities and the infrastructure required to support them. An overall site plan is recommended. Further, a series of layouts are included that depict site conditions as facilities are constructed at the SWMC site. In this respect the report serves not only as the siting basis for future projects, but provides siting guidance for Project W-112, as well. The plan is intended to function as a template for expected growth of the site over the next 30 years so that future facilities and infrastructure will be properly integrated.

  14. Surgical treatment of pulmonary aspergilloma.

    PubMed

    Ruiz Júnior, Raul Lopes; de Oliveira, Frederico Henrique Sobral; Piotto, Bruno Luiz Burgos; Muniz, Felipe Antunes e Silva de Souza Lopes; Cataneo, Daniele Cristina; Cataneo, Antonio José Maria

    2010-01-01

    The objective of this study was to analyze the outcome of surgical treatment of pulmonary aspergilloma. To that end, we evaluated 14 adult patients so treated between 1981 and 2009 at the Botucatu School of Medicine University Hospital, in the city of Botucatu, Brazil. Data were collected from the medical records of the patients. Ten patients (71%) presented with simple pulmonary aspergilloma, and 4 (29%) presented with complex pulmonary aspergilloma. Hemoptysis was the most common symptom, and tuberculosis was the most prevalent preexisting lung disease. Two patients (14%) underwent surgery on more than one occasion. There were no intraoperative deaths. Half of the patients developed postoperative complications, prolonged air leak and empyema being the most common. PMID:21225182

  15. History of Complex Numbers

    Microsoft Academic Search

    Ravi P. Agarwal; Kanishka Perera; Sandra Pinelas

    \\u000a The problem of complex numbers dates back to the 1st century, when Heron of Alexandria (about 75 AD) attempted to find the\\u000a volume of a frustum of a pyramid, which required computing the square root of 81-144 (though negative numbers were not conceived in the Hellenistic world). We also have the following quotation from Bhaskara\\u000a Acharya (working in 486 AD),

  16. Engineering Complex Tissues

    PubMed Central

    MIKOS, ANTONIOS G.; HERRING, SUSAN W.; OCHAREON, PANNEE; ELISSEEFF, JENNIFER; LU, HELEN H.; KANDEL, RITA; SCHOEN, FREDERICK J.; TONER, MEHMET; MOONEY, DAVID; ATALA, ANTHONY; VAN DYKE, MARK E.; KAPLAN, DAVID; VUNJAK-NOVAKOVIC, GORDANA

    2010-01-01

    This article summarizes the views expressed at the third session of the workshop “Tissue Engineering—The Next Generation,” which was devoted to the engineering of complex tissue structures. Antonios Mikos described the engineering of complex oral and craniofacial tissues as a “guided interplay” between biomaterial scaffolds, growth factors, and local cell populations toward the restoration of the original architecture and function of complex tissues. Susan Herring, reviewing osteogenesis and vasculogenesis, explained that the vascular arrangement precedes and dictates the architecture of the new bone, and proposed that engineering of osseous tissues might benefit from preconstruction of an appropriate vasculature. Jennifer Elisseeff explored the formation of complex tissue structures based on the example of stratified cartilage engineered using stem cells and hydrogels. Helen Lu discussed engineering of tissue interfaces, a problem critical for biological fixation of tendons and ligaments, and the development of a new generation of fixation devices. Rita Kandel discussed the challenges related to the re-creation of the cartilage-bone interface, in the context of tissue engineered joint repair. Frederick Schoen emphasized, in the context of heart valve engineering, the need for including the requirements derived from “adult biology” of tissue remodeling and establishing reliable early predictors of success or failure of tissue engineered implants. Mehmet Toner presented a review of biopreservation techniques and stressed that a new breakthrough in this field may be necessary to meet all the needs of tissue engineering. David Mooney described systems providing temporal and spatial regulation of growth factor availability, which may find utility in virtually all tissue engineering and regeneration applications, including directed in vitro and in vivo vascularization of tissues. Anthony Atala offered a clinician’s perspective for functional tissue regeneration, and discussed new biomaterials that can be used to develop new regenerative technologies. PMID:17518671

  17. Modeling Complex Calorimeters

    NASA Technical Reports Server (NTRS)

    Figueroa-Feliciano, Enectali

    2004-01-01

    We have developed a software suite that models complex calorimeters in the time and frequency domain. These models can reproduce all measurements that we currently do in a lab setting, like IV curves, impedance measurements, noise measurements, and pulse generation. Since all these measurements are modeled from one set of parameters, we can fully describe a detector and characterize its behavior. This leads to a model than can be used effectively for engineering and design of detectors for particular applications.

  18. 40 CFR 133.105 - Treatment equivalent to secondary treatment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 2010-07-01 2010-07-01 false Treatment equivalent to secondary treatment. 133.105 Section 133.105 Protection...AGENCY (CONTINUED) WATER PROGRAMS SECONDARY TREATMENT REGULATION § 133.105 Treatment...

  19. The Hybrid Treatment Process for mixed radioactive and hazardous waste treatment

    SciTech Connect

    Ross, W.A.; Kindle, C.H.

    1992-06-01

    This paper describes a new process for treating mixed hazardous and radioactive waste, commonly called mixed waste. The process is called the Hybrid Treatment Process (HTP), so named because it is built on the 20 years of experience with vitrification of wastes in melters, and the 12 years of experience with treatment of wastes by the in situ vitrification (ISV) process. It also uses techniques from several additional technologies. Mixed wastes are being generated by both the US Department of Energy (DOE) and by commercial sources. The wastes are those that contain both a hazardous waste regulated under the US Environmental Protection Agency`s (EPA) Resource, Conservation, and Recovery Act (RCRA) regulations and a radioactive waste with source, special nuclear, or byproduct materials. The dual regulation of the wastes increases the complexity of the treatment, handling, and storage of the waste. The DOE is the largest holder and generator of mixed waste. Its mixed wastes are classified as either high-level, transuranic (TRU), or low-level waste (LLW). High-level mixed wastes will be treated in vitrification plants. Transuranic wastes may be disposed of without treatment by obtaining a no-migration variance from the EPA. Lowlevel wastes, however, will require treatment, but treatment systems with sufficient capacity are not yet available to DOE. Various facilities are being proposed for the treatment of low-level waste. The concept described in this paper represents one option for establishing that treatment capacity.

  20. The Hybrid Treatment Process for mixed radioactive and hazardous waste treatment

    SciTech Connect

    Ross, W.A.; Kindle, C.H.

    1992-06-01

    This paper describes a new process for treating mixed hazardous and radioactive waste, commonly called mixed waste. The process is called the Hybrid Treatment Process (HTP), so named because it is built on the 20 years of experience with vitrification of wastes in melters, and the 12 years of experience with treatment of wastes by the in situ vitrification (ISV) process. It also uses techniques from several additional technologies. Mixed wastes are being generated by both the US Department of Energy (DOE) and by commercial sources. The wastes are those that contain both a hazardous waste regulated under the US Environmental Protection Agency's (EPA) Resource, Conservation, and Recovery Act (RCRA) regulations and a radioactive waste with source, special nuclear, or byproduct materials. The dual regulation of the wastes increases the complexity of the treatment, handling, and storage of the waste. The DOE is the largest holder and generator of mixed waste. Its mixed wastes are classified as either high-level, transuranic (TRU), or low-level waste (LLW). High-level mixed wastes will be treated in vitrification plants. Transuranic wastes may be disposed of without treatment by obtaining a no-migration variance from the EPA. Lowlevel wastes, however, will require treatment, but treatment systems with sufficient capacity are not yet available to DOE. Various facilities are being proposed for the treatment of low-level waste. The concept described in this paper represents one option for establishing that treatment capacity.

  1. Trauma-Focused CBT for Youth with Complex Trauma

    ERIC Educational Resources Information Center

    Cohen, Judith A.; Mannarino, Anthony P.; Kliethermes, Matthew; Murray, Laura A.

    2012-01-01

    Objectives: Many youth develop complex trauma, which includes regulation problems in the domains of affect, attachment, behavior, biology, cognition, and perception. Therapists often request strategies for using evidence-based treatments (EBTs) for this population. This article describes practical strategies for applying Trauma-Focused Cognitive…

  2. Schoolchildren with Dysphagia Associated with Medically Complex Conditions

    ERIC Educational Resources Information Center

    Lefton-Greif, Maureen A.; Arvedson, Joan C.

    2008-01-01

    Purpose: This article reviews population trends and general characteristics of children with dysphagia in schools, provides an overview of dysphagia teams and the roles of the speech-language pathologist (SLP) in school and hospital settings, and describes assessment and treatment of swallowing and feeding problems in children with complex medical…

  3. Tourette's disorder and associated complex behaviors: a case report.

    PubMed Central

    McDougle, C. J.; Southwick, S. M.; Rohrbaugh, R. M.

    1990-01-01

    A case of a man with Tourette's disorder associated with obsessive-compulsive disorder, multiple sexual paraphilias, and aggressive behavior is described. Treatment with haloperidol led to improvement in the characteristic tics of Tourette's disorder as well as to improvement in these three complex-associated behaviors. After haloperidol was discontinued, an exacerbation of tics and the associated behaviors occurred. PMID:2238716

  4. The Complexity of Evidence-Based Practice: A Case Study

    Microsoft Academic Search

    Beverly M. Simmons

    2011-01-01

    In this article, the author addresses areas of complexity within evidence-based social work practice that she has encountered in her work with clients. The author offers an in-depth case study from her practice that involves the assessment and treatment of a client with a complicated diagnostic presentation. Clinical choices are discussed using a biopsychosocial framework that highlights the importance of

  5. The canine contagious respiratory disease complex (kennel cough).

    PubMed

    Appel, M; Bemis, D A

    1978-01-01

    Several infectious agents are involved in the kennel cough complex in dogs. They include canine parainfluenza virus (SV5), canine adenovirus 2, Bordetella bronchiseptica, and possibly several mycoplasma species. The importance of each of these agents in the disease syndrome is discussed as well as possible prevention or treatment. PMID:204455

  6. The structure of the Rous sarcoma virus glycoprotein complex

    Microsoft Academic Search

    G. Pauli; W. Rohde; E. Harms

    1978-01-01

    Summary The viral envelope glycoprotein gp85 is released from purified Rous sarcoma virus by treatment with 2-mercaptoethanol, while the second surface antigen gp35 remains associated with the membrane of intact virus particles. The data represented substantiate and extend previous observations on the Rous sarcoma virus glycoprotein complex.

  7. Proteasome Inhibitors: Complex Tools for a Complex Enzyme

    E-print Network

    Bogyo, Matthew

    Proteasome Inhibitors: Complex Tools for a Complex Enzyme M. BOGYOOGYO 1 and E.W. WANGANG 2 1 Initial Inhibitors Studies ± Characterizing the Catalytic Mechanism of the Proteasome . . . . 186 3 Synthetic Inhibitors of the Proteasome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 188 3

  8. Linking social complexity and vocal complexity: a parid perspective

    PubMed Central

    Krams, Indrikis; Krama, Tatjana; Freeberg, Todd M.; Kullberg, Cecilia; Lucas, Jeffrey R.

    2012-01-01

    The Paridae family (chickadees, tits and titmice) is an interesting avian group in that species vary in important aspects of their social structure and many species have large and complex vocal repertoires. For this reason, parids represent an important set of species for testing the social complexity hypothesis for vocal communication—the notion that as groups increase in social complexity, there is a need for increased vocal complexity. Here, we describe the hypothesis and some of the early evidence that supported the hypothesis. Next, we review literature on social complexity and on vocal complexity in parids, and describe some of the studies that have made explicit tests of the social complexity hypothesis in one parid—Carolina chickadees, Poecile carolinensis. We conclude with a discussion, primarily from a parid perspective, of the benefits and costs of grouping and of physiological factors that might mediate the relationship between social complexity and changes in signalling behaviour. PMID:22641826

  9. Complexity: an internet resource for analysis of DNA sequence complexity

    PubMed Central

    Orlov, Y. L.; Potapov, V. N.

    2004-01-01

    The search for DNA regions with low complexity is one of the pivotal tasks of modern structural analysis of complete genomes. The low complexity may be preconditioned by strong inequality in nucleotide content (biased composition), by tandem or dispersed repeats or by palindrome-hairpin structures, as well as by a combination of all these factors. Several numerical measures of textual complexity, including combinatorial and linguistic ones, together with complexity estimation using a modified Lempel–Ziv algorithm, have been implemented in a software tool called ‘Complexity’ (http://wwwmgs.bionet.nsc.ru/mgs/programs/low_complexity/). The software enables a user to search for low-complexity regions in long sequences, e.g. complete bacterial genomes or eukaryotic chromosomes. In addition, it estimates the complexity of groups of aligned sequences. PMID:15215465

  10. 11. Pitzer Ranch Complex on Padua Avenue facing southwest. Complex ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pitzer Ranch Complex on Padua Avenue facing southwest. Complex is in foreground; vacant property and condominiums are in background. - Pitzer Ranch, Bounded by Base Line Road, Paoua & Towne Avenues, Claremont, Los Angeles County, CA

  11. Training Pseudoword Reading in Acquired Dyslexia: A Phonological Complexity Approach

    PubMed Central

    Riley, Ellyn A.; Thompson, Cynthia K.

    2015-01-01

    Background Individuals with acquired phonological dyslexia experience difficulty associating written letters with corresponding sounds, especially in pseudowords. Previous studies have shown that reading can be improved in these individuals by training letter-sound correspondence, practicing phonological skills, or using combined approaches. However, generalization to untrained items is typically limited. Aims We investigated whether principles of phonological complexity can be applied to training letter-sound correspondence reading in acquired phonological dyslexia to improve generalization to untrained words. Based on previous work in other linguistic domains, we hypothesized that training phonologically “more complex” material (i.e., consonant clusters with small sonority differences) would result in generalization to phonologically “less complex” material (i.e., consonant clusters with larger sonority differences), but this generalization pattern would not be demonstrated when training the “less complex” material. Methods & Procedures We used a single-participant, multiple baseline design across participants and behaviors to examine phonological complexity as a training variable in five individuals. Based on participants' error data from a previous experiment, a “more complex” onset and a “less complex” onset were selected for training for each participant. Training order assignment was pseudo-randomized and counterbalanced across participants. Three participants were trained in the “more complex” condition and two in the “less complex” condition while tracking oral reading accuracy of both onsets. Outcomes & Results As predicted, participants trained in the “more complex” condition demonstrated improved pseudoword reading of the trained cluster and generalization to pseudowords with the untrained, “simple” onset, but not vice versa. Conclusions These findings suggest phonological complexity can be used to improve generalization to untrained phonologically related words in acquired phonological dyslexia. These findings also provide preliminary support for using phonological complexity theory as a tool for designing more effective and efficient reading treatments for acquired dyslexia.

  12. Electrotechnologies for water treatment

    SciTech Connect

    Douglas, J.

    1993-03-01

    Water and wastewater utilities face major changes in their treatment systems as a result of recent environmental regulations. Not only do these new rules specify reduction requirements for contaminants not previously regulated, they also target the by-products of chlorination, which has been the basic disinfection technique in this country since the early days of municipal water treatment. As a result, EPRI has been working with the American Water Works Association Research Foundation and the Water Environment Research Foundation to support the development of advanced treatment alternatives and improve energy efficiency at treatment facilities. The work has identified a number of innovative, electrically based treatment technologies that provide the additional capabilities required, promote higher efficiency in treatment processes, and serve electric utilities' demand-side management objectives. 5 refs.

  13. Lasers for the treatment of psoriasis

    NASA Astrophysics Data System (ADS)

    Piruzian, A.; Korsunskaya, I.; Goldenkova, I.; Hertsen, A.; Sarkisova, M.; Egorenkova, L.

    2005-08-01

    Psoriasis is a chronic, genetically-determined disease, characterized by an immuno-mediated pathogenesis. Treatment of psoriasis is often complicated and remains a challenge. Along with the many new immunomodulatory approaches, various laser systems have been employed for chronic plaque psoriasis treatment. Recently, it has been demonstrated that the light produced by xenon-chloride excimers (generated by sophisticated devices with peak emission of 308 nm) is effective in the treatment of several psoriasis forms. We treated patients, ranging in age from 35 to 55 years, affected by plaque-type psoriasis vulgaris with monochromatic excimer light (MEL). We used MEL in a complex with basic treatment. Therapy was administered three times a week. At the end of the 3th week of treatment all patients showed an improvement, as evidenced by flattening of plaques, decreased scaling and erythema, and decreased vesicle and pustule formation. Unwanted side effects such as pain, blistering was not observed. Minimal erythema and a hyperpigmentation were noted in some patients. It was concluded that the MEL therapy may be a valuable option for treatment of plaque-type psoriasis vulgaris in shorter time compare with traditional NB UVB, with exposure to lower cumulative doses

  14. [Does patient knowledge improve treatment outcome?].

    PubMed

    Mühlhauser, Ingrid; Lenz, Matthias

    2008-01-01

    Non-compliance in patients is rarely provoked by intention or laziness. Thus, patients should not be the first to be blamed for lack of therapeutic success. Non-compliance from health care providers to supply patients with necessary information and skills, though, is an important cause of insufficient treatment outcomes. Patient knowledge can improve health outcomes. But this knowledge must be evidence-based and relevant for the patient. In addition, knowledge must enable patients to assume an important part in disease control and treatment. Evaluation of patient information or self-management programmes should consider that knowledge is just one component of a complex intervention. Self-management programmes for type 1 diabetes or severe asthma are examples of where patient knowledge as part of a complex intervention may lead to substantially improved treatment outcomes. Disease-unspecific self-management programmes like the expert patient programme do not lead to important changes of relevant outcome measures. Patients and consumers want to participate in medical decision-making. However, there is a lack of evidence-based patient information for most indications. Informed decision-making by patients may lead to intelligent non-compliance and worsening of treatment outcome according to conventional assessment criteria. Direct-to-consumer advertising (DTCA) hits a public that lacks competencies in critical health literacy. Critical health literacy which combines the concept of evidence-based medicine and health literacy should be integrated into existing school curricula. PMID:19004360

  15. Cognitive-behavioral treatments

    Microsoft Academic Search

    Philip C. Kendall; Susan M. Panichelli-Mindel

    1995-01-01

    The present paper provides an overview of the guiding theory and descriptive features of the cognitive-behavioral approach to psychosocial interventions for youths. Cognitive-behavioral treatment has been applied to various disorders including anxiety, aggression, depression, attention deficit-hyperactivity disorder, pain, and learning disabilities. Research on the nature of these disorders, a description of related treatment strategies, and an illustrative review of treatment

  16. Not so Complex: Iteration in the Complex Plane

    ERIC Educational Resources Information Center

    O'Dell, Robin S.

    2014-01-01

    The simple process of iteration can produce complex and beautiful figures. In this article, Robin O'Dell presents a set of tasks requiring students to use the geometric interpretation of complex number multiplication to construct linear iteration rules. When the outputs are plotted in the complex plane, the graphs trace pleasing designs…

  17. APPENDIX F. TRANSFORMS, COMPLEX ANALYSIS 1 Transforms, Complex

    E-print Network

    Callen, James D.

    APPENDIX F. TRANSFORMS, COMPLEX ANALYSIS 1 Appendix F Transforms, Complex Analysis This appendix discusses Fourier and Laplace transforms as they are used in plasma physics and this book. Also, key properties of complex variable theory that are needed for understanding and inverting these transforms

  18. DESCRIPTION OF A COMPLEX DISEASE: CORN STUNT COMPLEX

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The corn stunt disease complex is considered to be caused by two or more of a complex of maize rayado fino virus, corn stunt spiroplasma, and maize bushy stunt phytoplasma, and is also known by the names achaparramiento, maize stunt, and red stunt, among others. This complex appears to be restricte...

  19. [Treatment of occipitocervical instability by SUMMIT].

    PubMed

    Milinkovi?, Z B; Krneta, O; Milickovi?, S; Basara, V; Dozi?, D; Jesi?, B; Poleksi?, Z; Lalosevi?, V

    2010-01-01

    The occipitocervical junction with its complex anatomy and biomechanics represents unique anatomical structure difficult for operative treatment. Biomechanics forces in this region need to be resisted with rigid metallic construction to facilitate bone fusion. Surgeon must be careful about close relations of the bone, vascular and neurologic structures and must have good skills and knowledge to avoid serious complications during operations. Before 2004 for instability treatment in this region of spine wires and pin construction for fixation of bone grafts were used. In our Institute rod constructions with screws have been used to get more rigid construction since 2004. In this paper we will present our early results in occipitocervical instability treatment by SUMMIT instrumentation. PMID:20681201

  20. Enterobiasis (Pinworm Infection): Treatment

    MedlinePLUS

    ... Contact CDC-INFO Pinworm Infection General Information Pinworm Infection FAQs Epidemiology & Risk Factors Biology Disease Diagnosis Treatment Prevention & Control Resources for Health Professionals Publications Information For: Travelers ...

  1. Treatment Approaches (Palliative Care)

    MedlinePLUS

    ... such as anxiety and depression, treatment includes supportive psychotherapy and the use of antidepressant or anti-anxiety drugs. Psychotherapy may include relaxation training, imagery, distraction, coping training, ...

  2. Warts: Diagnosis, Treatment, and Outcome

    MedlinePLUS

    ... dermatologist may use one of the following treatments: Laser treatment : Laser treatment is an option, mainly for warts that have not responded to other therapies. Before laser treatment, the dermatologist may numb the wart with ...

  3. Thermal treatment of magnetite nanoparticles

    PubMed Central

    Wykowska, Urszula; Satula, Dariusz; Nordblad, Per

    2015-01-01

    Summary This paper presents the results of a thermal treatment process for magnetite nanoparticles in the temperature range of 50–500 °C. The tested magnetite nanoparticles were synthesized using three different methods that resulted in nanoparticles with different surface characteristics and crystallinity, which in turn, was reflected in their thermal durability. The particles were obtained by coprecipitation from Fe chlorides and decomposition of an Fe(acac)3 complex with and without a core–shell structure. Three types of ferrite nanoparticles were produced and their thermal stability properties were compared. In this study, two sets of unmodified magnetite nanoparticles were used where crystallinity was as determinant of the series. For the third type of particles, a Ag shell was added. By comparing the coated and uncoated particles, the influence of the metallic layer on the thermal stability of the nanoparticles was tested. Before and after heat treatment, the nanoparticles were examined using transmission electron microscopy, IR spectroscopy, differential scanning calorimetry, X-ray diffraction and Mössbauer spectroscopy. Based on the obtained results, it was observed that the fabrication methods determine, to some extent, the sensitivity of the nanoparticles to external factors. PMID:26199842

  4. Plasma Treatments and Biomass Gasification

    NASA Astrophysics Data System (ADS)

    Luche, J.; Falcoz, Q.; Bastien, T.; Leninger, J. P.; Arabi, K.; Aubry, O.; Khacef, A.; Cormier, J. M.; Lédé, J.

    2012-02-01

    Exploitation of forest resources for energy production includes various methods of biomass processing. Gasification is one of the ways to recover energy from biomass. Syngas produced from biomass can be used to power internal combustion engines or, after purification, to supply fuel cells. Recent studies have shown the potential to improve conventional biomass processing by coupling a plasma reactor to a pyrolysis cyclone reactor. The role of the plasma is twofold: it acts as a purification stage by reducing production of tars and aerosols, and simultaneously produces a rich hydrogen syngas. In a first part of the paper we present results obtained from plasma treatment of pyrolysis oils. The outlet gas composition is given for various types of oils obtained at different experimental conditions with a pyrolysis reactor. Given the complexity of the mixtures from processing of biomass, we present a study with methanol considered as a model molecule. This experimental method allows a first modeling approach based on a combustion kinetic model suitable to validate the coupling of plasma with conventional biomass process. The second part of the paper is summarizing results obtained through a plasma-pyrolysis reactor arrangement. The goal is to show the feasibility of this plasma-pyrolysis coupling and emphasize more fundamental studies to understand the role of the plasma in the biomass treatment processes.

  5. Quantum Computing and Communication Complexity

    E-print Network

    ten Cate, Balder

    Quantum Computing and Communication Complexity Ronald de Wolf #12; #12; Quantum Computing: http://www.illc.uva.nl/ #12; Quantum Computing and Communication Complexity Academisch Proefschrift ter Quantum Computing 1 1.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1

  6. Complex Compound Chemical Heat Pumps

    E-print Network

    Rockenfeller, U.; Langeliers, J.; Horn, G.

    Complex-compound solid-vapor fluid pairs can be used in heat of reaction heat pumps for temperature amplifier (TA) as well as heat amplifier (HA) cycle configurations. This report describes the conceptual hardware design for complex compound...

  7. Genotoxicity of complex chemical mixtures

    E-print Network

    Phillips, Tracie Denise

    2009-05-15

    , distribution, metabolism or excretion of the components of a complex mixture. The research conducted for this dissertation has coupled chemical fractionation with in vitro and in vivo bioassays to assess the potential carcinogenic risk of complex mixtures. A...

  8. Complexity of Algorithms Lecture Notes

    E-print Network

    Grolmusz, Vince

    Access Machine . . . . . . . . . . . . . . . . . . . . . . . 22 1.4 Boolean functions and BooleanComplexity of Algorithms Lecture Notes László Lovász Eötvös Loránd University Institute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 3.2 Other complexity classes . . . . . . . . . . . . . . . . . . . . . . . . . . 66 3.3 General

  9. Complex-valued autoencoders.

    PubMed

    Baldi, Pierre; Lu, Zhiqin

    2012-09-01

    Autoencoders are unsupervised machine learning circuits, with typically one hidden layer, whose learning goal is to minimize an average distortion measure between inputs and outputs. Linear autoencoders correspond to the special case where only linear transformations between visible and hidden variables are used. While linear autoencoders can be defined over any field, only real-valued linear autoencoders have been studied so far. Here we study complex-valued linear autoencoders where the components of the training vectors and adjustable matrices are defined over the complex field with the L(2) norm. We provide simpler and more general proofs that unify the real-valued and complex-valued cases, showing that in both cases the landscape of the error function is invariant under certain groups of transformations. The landscape has no local minima, a family of global minima associated with Principal Component Analysis, and many families of saddle points associated with orthogonal projections onto sub-space spanned by sub-optimal subsets of eigenvectors of the covariance matrix. The theory yields several iterative, convergent, learning algorithms, a clear understanding of the generalization properties of the trained autoencoders, and can equally be applied to the hetero-associative case when external targets are provided. Partial results on deep architecture as well as the differential geometry of autoencoders are also presented. The general framework described here is useful to classify autoencoders and identify general properties that ought to be investigated for each class, illuminating some of the connections between autoencoders, unsupervised learning, clustering, Hebbian learning, and information theory. PMID:22622264

  10. Nonlocality and communication complexity

    NASA Astrophysics Data System (ADS)

    Buhrman, Harry; Cleve, Richard; Massar, Serge; de Wolf, Ronald

    2010-01-01

    Quantum information processing is the emerging field that defines and realizes computing devices that make use of quantum mechanical principles such as the superposition principle, entanglement, and interference. Until recently the common notion of computing was based on classical mechanics and did not take into account all the possibilities that physically realizable computing devices offer in principle. The field gained momentum after Shor developed an efficient algorithm for factoring numbers, demonstrating the potential computing powers that quantum computing devices can unleash. In this review the information counterpart of computing is studied. It was realized early on by Holevo that quantum bits, the quantum mechanical counterpart of classical bits, cannot be used for efficient transformation of information in the sense that arbitrary k -bit messages cannot be compressed into messages of k-1 qubits. The abstract form of the distributed computing setting is called communication complexity. It studies the amount of information, in terms of bits or in our case qubits, that two spatially separated computing devices need to exchange in order to perform some computational task. Surprisingly, quantum mechanics can be used to obtain dramatic advantages for such tasks. The area of quantum communication complexity is reviewed and it is shown how it connects the foundational physics questions regarding nonlocality with those of communication complexity studied in theoretical computer science. The first examples exhibiting the advantage of the use of qubits in distributed information-processing tasks were based on nonlocality tests. However, by now the field has produced strong and interesting quantum protocols and algorithms of its own that demonstrate that entanglement, although it cannot be used to replace communication, can be used to reduce the communication exponentially. In turn, these new advances yield a new outlook on the foundations of physics and could even yield new proposals for experiments that test the foundations of physics.

  11. Complex-Valued Autoencoders

    PubMed Central

    Baldi, Pierre; Lu, Zhiqin

    2012-01-01

    Autoencoders are unsupervised machine learning circuits, with typically one hidden layer, whose learning goal is to minimize an average distortion measure between inputs and outputs. Linear autoencoders correspond to the special case where only linear transformations between visible and hidden variables are used. While linear autoencoders can be defined over any field, only real-valued linear autoencoders have been studied so far. Here we study complex-valued linear autoencoders where the components of the training vectors and adjustable matrices are defined over the complex field with the L2 norm. We provide simpler and more general proofs that unify the real-valued and complex-valued cases, showing that in both cases the landscape of the error function is invariant under certain groups of transformations. The landscape has no local minima, a family of global minima associated with Principal Component Analysis, and many families of saddle points associated with orthogonal projections onto sub-space spanned by sub-optimal subsets of eigenvectors of the covariance matrix. The theory yields several iterative, convergent, learning algorithms, a clear understanding of the generalization properties of the trained autoencoders, and can equally be applied to the hetero-associative case when external targets are provided. Partial results on deep architecture as well as the differential geometry of autoencoders are also presented. The general framework described here is useful to classify autoencoders and identify general properties that ought to be investigated for each class, illuminating some of the connections between autoencoders, unsupervised learning, clustering, Hebbian learning, and information theory. PMID:22622264

  12. Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

    PubMed Central

    Chien, Wai Tong; Yip, Annie LK

    2013-01-01

    During the last three decades, an increasing understanding of the etiology, psychopathology, and clinical manifestations of schizophrenia spectrum disorders, in addition to the introduction of second-generation antipsychotics, has optimized the potential for recovery from the illness. Continued development of various models of psychosocial intervention promotes the goal of schizophrenia treatment from one of symptom control and social adaptation to an optimal restoration of functioning and/or recovery. However, it is still questionable whether these new treatment approaches can address the patients’ needs for treatment and services and contribute to better patient outcomes. This article provides an overview of different treatment approaches currently used in schizophrenia spectrum disorders to address complex health problems and a wide range of abnormalities and impairments resulting from the illness. There are different treatment strategies and targets for patients at different stages of the illness, ranging from prophylactic antipsychotics and cognitive–behavioral therapy in the premorbid stage to various psychosocial interventions in addition to antipsychotics for relapse prevention and rehabilitation in the later stages of the illness. The use of antipsychotics alone as the main treatment modality may be limited not only in being unable to tackle the frequently occurring negative symptoms and cognitive impairments but also in producing a wide variety of adverse effects to the body or organ functioning. Because of varied pharmacokinetics and treatment responsiveness across agents, the medication regimen should be determined on an individual basis to ensure an optimal effect in its long-term use. This review also highlights that the recent practice guidelines and standards have recommended that a combination of treatment modalities be adopted to meet the complex health needs of people with schizophrenia spectrum disorders. In view of the heterogeneity of the risk factors and the illness progression of individual patients, the use of multifaceted illness management programs consisting of different combinations of physical, psychological, and social interventions might be efficient and effective in improving recovery. PMID:24049446

  13. Exploring complex networks

    NASA Astrophysics Data System (ADS)

    Strogatz, Steven H.

    2001-03-01

    The study of networks pervades all of science, from neurobiology to statistical physics. The most basic issues are structural: how does one characterize the wiring diagram of a food web or the Internet or the metabolic network of the bacterium Escherichia coli? Are there any unifying principles underlying their topology? From the perspective of nonlinear dynamics, we would also like to understand how an enormous network of interacting dynamical systems - be they neurons, power stations or lasers - will behave collectively, given their individual dynamics and coupling architecture. Researchers are only now beginning to unravel the structure and dynamics of complex networks.

  14. Complex thermoelectric materials.

    PubMed

    Snyder, G Jeffrey; Toberer, Eric S

    2008-02-01

    Thermoelectric materials, which can generate electricity from waste heat or be used as solid-state Peltier coolers, could play an important role in a global sustainable energy solution. Such a development is contingent on identifying materials with higher thermoelectric efficiency than available at present, which is a challenge owing to the conflicting combination of material traits that are required. Nevertheless, because of modern synthesis and characterization techniques, particularly for nanoscale materials, a new era of complex thermoelectric materials is approaching. We review recent advances in the field, highlighting the strategies used to improve the thermopower and reduce the thermal conductivity. PMID:18219332

  15. Organization of complex networks

    NASA Astrophysics Data System (ADS)

    Kitsak, Maksim

    Many large complex systems can be successfully analyzed using the language of graphs and networks. Interactions between the objects in a network are treated as links connecting nodes. This approach to understanding the structure of networks is an important step toward understanding the way corresponding complex systems function. Using the tools of statistical physics, we analyze the structure of networks as they are found in complex systems such as the Internet, the World Wide Web, and numerous industrial and social networks. In the first chapter we apply the concept of self-similarity to the study of transport properties in complex networks. Self-similar or fractal networks, unlike non-fractal networks, exhibit similarity on a range of scales. We find that these fractal networks have transport properties that differ from those of non-fractal networks. In non-fractal networks, transport flows primarily through the hubs. In fractal networks, the self-similar structure requires any transport to also flow through nodes that have only a few connections. We also study, in models and in real networks, the crossover from fractal to non-fractal networks that occurs when a small number of random interactions are added by means of scaling techniques. In the second chapter we use k-core techniques to study dynamic processes in networks. The k-core of a network is the network's largest component that, within itself, exhibits all nodes with at least k connections. We use this k-core analysis to estimate the relative leadership positions of firms in the Life Science (LS) and Information and Communication Technology (ICT) sectors of industry. We study the differences in the k-core structure between the LS and the ICT sectors. We find that the lead segment (highest k-core) of the LS sector, unlike that of the ICT sector, is remarkably stable over time: once a particular firm enters the lead segment, it is likely to remain there for many years. In the third chapter we study how epidemics spread though networks. Our results indicate that a virus is more likely to infect a large area of a network if it originates at a node contained within k-core of high index k.

  16. Physics and complexity

    PubMed Central

    Sherrington, David

    2010-01-01

    This paper is concerned with complex macroscopic behaviour arising in many-body systems through the combinations of competitive interactions and disorder, even with simple ingredients at the microscopic level. It attempts to indicate and illustrate the richness that has arisen, in conceptual understanding, in methodology and in application, across a large range of scientific disciplines, together with a hint of some of the further opportunities that remain to be tapped. In doing so, it takes the perspective of physics and tries to show, albeit rather briefly, how physics has contributed and been stimulated. PMID:20123753

  17. Alcoholics' Evaluations of Alcoholism Treatment

    Microsoft Academic Search

    Alisdair Mackenzie; Richard P. Allen

    2003-01-01

    A sample of alcoholics who have considerable experience as participants in alcoholism treatment are interviewed for their recommendations and criticisms of treatment. Inpatient Milieu and Alcoholics Anonymous were the most frequent choices of treatments considered beneficial. Among treatments not recommended were specific inpatient facilities. Our subjects' evaluations are compared with published reviews of treatment outcome studies. The relationships between treatment

  18. Biopsychosocial Health Care Needs at the Emergency Room: Challenge of Complexity

    PubMed Central

    Matzer, Franziska; Wisiak, Ursula V.; Graninger, Monika; Söllner, Wolfgang; Stilling, Hans Peter; Glawischnig-Goschnik, Monika; Lueger, Andreas; Fazekas, Christian

    2012-01-01

    Background In an emergency room of internal medicine, triage and treatment of patients deserve first priority. However, biopsychosocial case complexity may also affect patient health outcome but has not yet been explored in this setting. Therefore, the aims of the study are (1) to estimate prevalence rates of complex patients in the emergency room (ER), (2) to describe biopsychosocial complexity in this population and (3) to evaluate possible correlations between patient profiles regarding case complexity and further clinical treatment. Methods During a study period of one week, all patients of an emergency room of internal medicine who were triaged to Manchester levels three to five were invited to participate in the study. Biopsychosocial case complexity was assessed by the INTERMED method. Psychosocial interventions were evaluated based on all documented interventions and recommendations given at the emergency room and during inpatient treatment. Results Study participants consisted of 167 patients with a subgroup of 19% (n?=?32) receiving subsequent inpatient-treatment at the department. High biopsychosocial case complexity was found in 12% (n?=?20) of the total sample (INTERMED score >20). This finding was paralleled by a cluster analysis suggesting three clusters with one highly complex patient group of 14%. These highly complex patients differed significantly from the other clusters as they had visited the emergency room more often within the last year and lived alone more frequently. In addition, admission rates were highest in this group. During ER treatment and subsequent inpatient treatment, 21% of highly complex patients received interventions addressing psychosocial factors as compared to 6% and 7%, respectively, in the other clusters. Conclusions A standardized screening of biopsychosocial case complexity among ‘frequent utilizers’ of the ER would be helpful to detect specific multidisciplinary health care needs among this particularly burdened patient group. PMID:22952586

  19. Image denoising with complex ridgelets

    Microsoft Academic Search

    Guangyi Chen; Balázs Kégl

    2007-01-01

    In this paper, we propose a novel image denoising method by incorporating the dual-tree complex wavelets into the ordinary ridgelet transform. The approximate shift invariant property of the dual-tree complex wavelet and the high directional sensitivity of the ridgelet transform make the new method a very good choice for image denoising. We apply the digital complex ridgelet transform to denoise

  20. Complex Ridgelets for Image Denoising

    Microsoft Academic Search

    G. Y. Chen

    In this paper, we propose a novel image denoising method by incorporating the dual-tree complex wavelets into the ordinary ridgelet transform. The approximate shift invariant property of the dual-tree complex wavelet and the high directional sensitivity of the ridgelet transform make the new method a very good choice for image denoising. We apply the digital complex ridgelet transform to the

  1. Complex Numbers First: Define i

    E-print Network

    Sands, Jonathan W.

    Complex Numbers First: Define i Solve the quadratic: Ryan Tarring Max Van Over Mike Diamond Mentor therefore, #12;The set of complex numbers is when we add real numbers to real multiples of this imaginary unit Complex numbers are written in the form: a +bi for real numbers a&b if b is not equal to 0 #12

  2. Euler's number II: Complex exponentials

    NSDL National Science Digital Library

    2013-06-21

    We express the exponential function of an imaginary variable in terms of sine and cosine. The "complex exponentials" that result trace out a circle in the complex plane. Pointing to one of the positions in the complex plane, we obtain the identity exp(i pi) = -1.

  3. MATROID COMPLEXITY AND NONSUCCINCT DESCRIPTIONS

    E-print Network

    Mayhew, Dillon

    MATROID COMPLEXITY AND NONSUCCINCT DESCRIPTIONS DILLON MAYHEW Abstract. We investigate an approach to matroid complexity that in- volves describing a matroid via a list of independent sets, bases, circuits to P. 1. Introduction The study of matroid-theoretical algorithmic problems and their complex- ity has

  4. COUNTING IRREDUCIBLE COMPONENTS OF COMPLEX

    E-print Network

    BĂĽrgisser, Peter

    COUNTING IRREDUCIBLE COMPONENTS OF COMPLEX ALGEBRAIC VARIETIES Peter B¨urgisser and Peter Scheiblechner Abstract. We present an algorithm for counting the irreducible com- ponents of a complex algebraic the irreducible components of the complex zero set of given polynomials f1, . . . , fr C[X1, . . . , Xn

  5. 6, 9811022, 2006 Radical complexes

    E-print Network

    Paris-Sud XI, Université de

    ACPD 6, 981­1022, 2006 Radical complexes and ozone loss processes B. Vogel et al. Title Page Discussions The potential impact of ClOx radical complexes on polar stratospheric ozone loss processes B Radical complexes and ozone loss processes B. Vogel et al. Title Page Abstract Introduction Conclusions

  6. Canberra Deep Dish Communications Complex

    NASA Technical Reports Server (NTRS)

    1990-01-01

    View of Canberra 70m (230 ft.) antenna with flags from the three Deep Space Network sites. The Canberra Deep Space Communications Complex, located outside Canberra, Australia, is one of the three complexes which comprise NASA's Deep Space Network. The other complexes are located in Goldstone, California, and Madrid, Spain.

  7. EXPANDED BED BIOLOGICAL TREATMENT

    EPA Science Inventory

    A three-year pilot-scale research investigation at the EPA Lebanon Pilot Plant was conducted to evaluate the feasibility of a unique biological secondary treatment process, designated the Expanded Bed Biological Treatment Process (EBBT). The EBBT process is a three-phase (oxygen/...

  8. Treatment of Alcohol Withdrawal

    Microsoft Academic Search

    Hugh Myrick; Raymond F. Anton

    Appropriate treatment of alcohol withdrawal (AW) can relieve the patient's discomfort, prevent the development of more serious symptoms, and forestall cumulative effects that might worsen future withdrawals. Hospital admission provides the safest setting for the treatment of AW, although many patients with mild to moderate symptoms can be treated successfully on an outpatient basis. Severe AW requires pharmacological intervention. Although

  9. Generic phytosanitary irradiation treatments

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The history of the development of generic phytosanitary irradiation (PI) treatments is discussed beginning with its initial proposal in 1986. Generic PI treatments in use today are 150 Gy for all hosts of Tephritidae, 250 Gy for all arthropods on mango and papaya shipped from Australia to New Zeala...

  10. Treatment of Evolution Inconsistent

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2005-01-01

    State standards for academic content vary enormously in how well they cover the topic of evolution, with many of those documents either ignoring or giving scant treatment to the core principles of that established scientific theory. This article presents the analysis of Education Week on state's standards treatment of evolution. Nearly all the…

  11. Emergency Medical Treatment Required

    E-print Network

    Sura, Philip

    or Chemical Exposure Occurs * Laboratory Employee Faculty, Post Doc, Technician, Graduate Student (whenEmergency Medical Treatment Required Non-Emergency Medical Treatment Required If possible, get help present if possible AmeriSys will complete the "First Report of Injury or Illness" and authorize medical

  12. Treatment of Essential Tremor

    MedlinePLUS

    ... other treatment options. Two types of brain surgery, deep brain stimulation (DBS) and thalamotomy, are used to treat essential tremor. Both treatments affect the thalamus. This is a cluster of nerve cells deep in the brain. In DBS, an electric probe ( ...

  13. Seed Treatment. Bulletin 760.

    ERIC Educational Resources Information Center

    Lowery, Harvey C.

    This manual gives a definition of seed treatment, the types of seeds normally treated, diseases and insects commonly associated with seeds, fungicides and insecticides used, types of equipment used for seed treatment, and information on labeling and coloring of treated seed, pesticide carriers, binders, stickers, and safety precautions. (BB)

  14. Treatment of urinary incontinence.

    PubMed

    Rovner, E S

    2000-10-01

    The treatment of urinary incontinence is a dynamic and evolving field. New therapies, techniques, and procedures, as well as some subtle refinements in treatments currently used, offer hope for the millions of people suffering from this condition. Recent attention has been directed toward reevaluating the efficacy and durability of some standard treatments for stress urinary incontinence, including pelvic floor exercise, bladder neck suspensions, and pubovaginal slings. Occlusive or supportive devices have evolved into a suitable alternative in some patients. Extracorporeal magnetic therapy and alternative periurethral injectable agents may offer additional treatment strategies for the relief of symptomatic stress urinary incontinence. New drugs for the treatment of overactive bladder and urge urinary incontinence have been introduced recently and, in combination with neuromodulation, offer the first new treatments for this condition in over 25 years. Yet, as rapidly as new therapies become available for the treatment of urinary incontinence, problems have become evident with some that were introduced just a short time ago. Thus, cautious skepticism regarding these "new and improved" treatments should be maintained until long-term data become available with respect to safety, efficacy, and durability. PMID:12084319

  15. Prosecution to Enhance Treatment.

    ERIC Educational Resources Information Center

    Goldsmith, Stephen

    1990-01-01

    Advocates the use of criminal prosecution of pregnant women who abuse illegal substances. Discusses the views that use of drugs is a form of illness and that pregnant women should be exempt from laws. Concludes that court supervision and sanctions can improve treatment. Argues that punishment and treatment need not be mutually exclusive and…

  16. Perinatal Substance Abuse Treatment

    Microsoft Academic Search

    Embry M Howell; Ira J Chasnoff

    1999-01-01

    Thirty-three focus groups were conducted with pregnant women in substance abuse treatment and their providers in order to identify factors in women's lives that facilitate and hamper their treatment process and successful program components to address the needs of this high-risk population. The focus groups were conducted as part of a larger evaluation of demonstrations funded by the Health Care

  17. Offenders: Characteristics and Treatment.

    ERIC Educational Resources Information Center

    Becker, Judith V.

    1994-01-01

    Reviews what is known about child sex offenders and their treatment. The author discusses the role of paraphilia in child molestation and reviews what is known about juvenile and incest offenders and recidivism rates. What is known about recidivism of untreated offenders and treatment practices is also summarized. Recommendations conclude the…

  18. Tyrosinaemia — treatment and outcome

    Microsoft Academic Search

    E. A. Kvittingen

    1995-01-01

    Tyrosinaemia type I is, untreated, a fatal disease: in the acute form from liver failure, in the chronic form often from hepatocellular carcinoma. Acute neurological crisis is also a cause of death. Traditionally the treatment has been with diet, but for a decade liver transplantation has been the ultimate treatment. The continuous production of the pathological metabolites in the kidneys

  19. Energy in wastewater treatment

    Microsoft Academic Search

    1982-01-01

    The purpose of this book is to examine the role of energy in wastewater treatment and to consolidate the information into a single document to provide a framework for future investigations in this area. Part I identifies the key factors that influence energy consumption in wastewater treatment and characterizes the relationship of energy use in wastewater processing to consumption in

  20. Plasma treatment of polydimethylsiloxane

    Microsoft Academic Search

    Michael J. Owen; Patrick J. Smith

    1994-01-01

    Plasma treatment of silicone surfaces is a useful way of increasing wettability to improve adhesion and a first step in producing various organosilicon thin-film composites. Despite numerous earlier studies, there is no consensus on the effect of plasma treatment nor on the mechanism of the subsequent hydrophobic recovery. X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) were used to