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1

Sequential Versus Concurrent Trastuzumab in Adjuvant Chemotherapy for Breast Cancer  

PubMed Central

Purpose NCCTG (North Central Cancer Treatment Group) N9831 is the only randomized phase III trial evaluating trastuzumab added sequentially or used concurrently with chemotherapy in resected stages I to III invasive human epidermal growth factor receptor 2–positive breast cancer. Patients and Methods Patients received doxorubicin and cyclophosphamide every 3 weeks for four cycles, followed by paclitaxel weekly for 12 weeks (arm A), paclitaxel plus sequential trastuzumab weekly for 52 weeks (arm B), or paclitaxel plus concurrent trastuzumab for 12 weeks followed by trastuzumab for 40 weeks (arm C). The primary end point was disease-free survival (DFS). Results Comparison of arm A (n = 1,087) and arm B (n = 1,097), with 6-year median follow-up and 390 events, revealed 5-year DFS rates of 71.8% and 80.1%, respectively. DFS was significantly increased with trastuzumab added sequentially to paclitaxel (log-rank P < .001; arm B/arm A hazard ratio [HR], 0.69; 95% CI, 0.57 to 0.85). Comparison of arm B (n = 954) and arm C (n = 949), with 6-year median follow-up and 313 events, revealed 5-year DFS rates of 80.1% and 84.4%, respectively. There was an increase in DFS with concurrent trastuzumab and paclitaxel relative to sequential administration (arm C/arm B HR, 0.77; 99.9% CI, 0.53 to 1.11), but the P value (.02) did not cross the prespecified O'Brien-Fleming boundary (.00116) for the interim analysis. Conclusion DFS was significantly improved with 52 weeks of trastuzumab added to adjuvant chemotherapy. On the basis of a positive risk-benefit ratio, we recommend that trastuzumab be incorporated into a concurrent regimen with taxane chemotherapy as an important standard-of-care treatment alternative to a sequential regimen.

Perez, Edith A.; Suman, Vera J.; Davidson, Nancy E.; Gralow, Julie R.; Kaufman, Peter A.; Visscher, Daniel W.; Chen, Beiyun; Ingle, James N.; Dakhil, Shaker R.; Zujewski, JoAnne; Moreno-Aspitia, Alvaro; Pisansky, Thomas M.; Jenkins, Robert B.

2011-01-01

2

Performance prediction of concurrent systems  

SciTech Connect

Concurrent systems are computers that use multiple processors to solve a single problem. A means to predict the application performance on these systems is a useful tool in many areas of concurrent system research. A computationally efficient and accurate method to predict performance for a class of parallel computations on concurrent systems is described. A parallel computation is modeled as a task system with precedence relationships expressed as a series parallel directed acyclic graph. Resources in concurrent systems are modeled as service centers in queueing network models. Using these two models as inputs, the method outputs predictions of both the time to complete the computation and the concurrent system utilization. The algorithm used is based on the approximate Mean Value Analysis in queueing network modeling with extensions to model concurrency in the computation. The new algorithm was validated against both detailed simulation and actual execution on a commercial multiprocessor.

Mak, V.W.K.

1987-12-01

3

Concurrent chemoradiotherapy followed by adjuvant chemotherapy in uterine cervical cancer patients with high-risk factors  

Microsoft Academic Search

ObjectivesTo determine whether concurrent chemoradiotherapy (CCRT) followed by adjuvant chemotherapy is better than CCRT alone in the management of FIGO stage bulky IB and IIB uterine cervical cancer.

Yong Bae Kim; Jae Ho Cho; Ki Chang Keum; Chang Geol Lee; Jinsil Seong; Chang Ok Suh; Gwi Eon Kim

2007-01-01

4

Concurrent adjuvant chemotherapy and immediate breast reconstruction with skin expanders after mastectomy for breast cancer  

Microsoft Academic Search

Background. Immediate breast reconstruction (IBR) by means of skin expander is currently one of the most widely used methods of breast reconstruction in mastectomized patients. However, given that many breast cancer patients usually receive adjuvant chemotherapy, the adoption of IBR raises new questions concerning possible cumulative toxicity. The present study reports our experience in the use of concurrent adjuvant chemotherapy

Orazio Caffo; Daniela Cazzolli; Alberto Scalet; Bruno Zani; Gianni Ambrosini; Maurizio Amichetti; Daniele Bernardi; Sonia Brugnara; Gianni Ciaghi; Antonio Lucenti; Ninoo Natale; Silvio Agugiaro; Claudio Eccher; Enzo Galligioni

2000-01-01

5

Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer  

SciTech Connect

Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical outcomes are encouraging. Prospective comparison with more traditional approach is warranted.

Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Guo Xiaomao [Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Palmer, Matthew [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-07-01

6

Breast cancer local recurrence under the form of inflammatory carcinoma, treated with concurrent radiation and chemotherapy, a case report.  

PubMed

The authors present a case report of a patient with breast cancer diagnosed in 2005, treated with conservative surgery, adjuvant chemotherapy and radiotherapy, followed by hormonal therapy until 2010, who relapsed under the form of inflammatory breast cancer in 2011. After tumor progression detected during primary systemic therapy, a concurrent radiation and radiosensitizing chemotherapy were proposed. There was a significant clinical response to this treatment, enabling curative chance with total mastectomy. The histological examination of the breast and regional lymph nodes revealed a complete response, since there was no evidence of residual tumor. There are few reports concerning concurrent radiotherapy and chemotherapy in locally advanced breast cancer, but it could be a suitable "loco regional rescue therapy" to further reduce tumor progression and allow curative surgery. Study of this treatment strategy in randomized clinical trials is warranted. PMID:24936322

Reis, Isabel; Pereira, Helena; Azevedo, Isabel; Conde, João; Bravo, Isabel; Craveiro, Rogéria; Pereira, Deolinda

2014-01-01

7

Automated Concurrent Blackboard System Generation in C++.  

National Technical Information Service (NTIS)

In his 1992 Ph.D. thesis, 'Design and Analysis Techniques for Concurrent Blackboard Systems', John McManus defined several performance metrics for concurrent blackboard systems and developed a suite of tools for creating and analyzing such systems. These ...

J. A. Kaplan J. W. McManus W. L. Bynum

1999-01-01

8

Concurrent ultrasonic weld evaluation system  

DOEpatents

A system for concurrent, non-destructive evaluation of partially completed welds for use in conjunction with an automated welder is disclosed. The system utilizes real time, automated ultrasonic inspection of a welding operation as the welds are being made by providing a transducer which follows a short distance behind the welding head. Reflected ultrasonic signals are analyzed utilizing computer based digital pattern recognition techniques to discriminate between good and flawed welds on a pass by pass basis. The system also distinguishes between types of weld flaws. 5 figs.

Hood, D.W.; Johnson, J.A.; Smartt, H.B.

1987-12-15

9

Concurrent ultrasonic weld evaluation system  

DOEpatents

A system for concurrent, non-destructive evaluation of partially completed welds for use in conjunction with an automated welder. The system utilizes real time, automated ultrasonic inspection of a welding operation as the welds are being made by providing a transducer which follows a short distance behind the welding head. Reflected ultrasonic signals are analyzed utilizing computer based digital pattern recognition techniques to discriminate between good and flawed welds on a pass by pass basis. The system also distinguishes between types of weld flaws.

Hood, Donald W. (Idaho Falls, ID); Johnson, John A. (Idaho Falls, ID); Smartt, Herschel B. (Idaho Falls, ID)

1987-01-01

10

Concurrent ultrasonic weld evaluation system  

DOEpatents

A system for concurrent, non-destructive evaluation of partially completed welds for use in conjunction with an automated welder. The system utilizes real time, automated ultrasonic inspection of a welding operation as the welds are being made by providing a transducer which follows a short distance behind the welding head. Reflected ultrasonic signals are analyzed utilizing computer based digital pattern recognition techniques to discriminate between good and flawed welds on a pass by pass basis. The system also distinguishes between types of weld flaws.

Hood, D.W.; Johnson, J.A.; Smartt, H.B.

1985-09-04

11

Concurrency Control and Recovery in Database Systems  

Microsoft Academic Search

This book is an introduction to the design and implementation of concurrency control and recovery mechanisms for transaction management in centralized and distributed database systems. Concurrency control and recovery have become increasingly important as businesses rely more and more heavily on their on-line data processing activities. For high performance, the system must maximize concurrency by multiprogramming transactions. But this can

Philip A. Bernstein; Vassos Hadzilacos; Nathan Goodman

1987-01-01

12

Concurrent chemotherapy inhibits Herpes simplex virus 1 replication and oncolysis  

PubMed Central

Herpes simplex virus 1 (HSV-1) replication in cancer cells leads to their destruction (viral oncolysis) and has been under investigation as an experimental cancer therapy in clinical trials as single agents, and as combinations with chemotherapy. Cellular responses to chemotherapy modulate viral replication, but these interactions are poorly understood. To investigate the effect of chemotherapy on HSV-1 oncolysis, viral replication in cells exposed to 5-fluorouracil (5-FU), irinotecan (CPT-11), methotrexate (MTX) or a cytokine (TNF-?) was examined. Exposure of colon and pancreatic cancer cells to 5-FU, CPT-11, or MTX in vitro significantly antagonizes both HSV-1 replication and lytic oncolysis. Nuclear factor-kappa B (NF-?B) activation is required for efficient viral replication, and experimental inhibition of this response with an I?B? dominant-negative repressor significantly antagonizes HSV-1 replication. Nonetheless cells exposed to 5-FU, CPT-11, TNF-? or HSV-1 activate NF-?B. Cells exposed to MTX do not activate NF-?B, suggesting a possible role for NF-?B inhibition in the decreased viral replication observed following exposure to MTX. The role of eukaryotic initiation factor 2 alpha (eIF-2?) dephosphorylation was examined; HSV-1 mediated eIF-2? dephosphorylation proceeds normally in HT29 cells exposed to 5-FU-, CPT-11-, or MTX. This report demonstrates that cellular responses to chemotherapeutic agents provide an unfavorable environment for HSV-1-mediated oncolysis, and these observations are relevant to the design of both preclinical and clinical studies of HSV-1 oncolysis.

Kulu, Yakup; Kawasaki, Hiroshi; Donahue, James M.; Kasuya, Hideki; Cusack, James C.; Choi, Enid W.; Kuruppu, Darshini K.; Fuchs, Bryan C.; Tanabe, Kenneth K.

2013-01-01

13

Resilient Concurrency Control in Distributed Database Systems  

Microsoft Academic Search

This paper presents the resiliency features of the optimistic approach to concurrency control and demonstrates how it lends itself to a design of a reliable distributed database system. The validation of concurrency control, integrity control, and atomicity control has been integrated. This integration provides a high degree of concurrency and continuity of operations in spite of failures of transactions, processors,

Bharat Bhargava

1983-01-01

14

Automated Concurrent Blackboard System Generation in C++  

NASA Technical Reports Server (NTRS)

In his 1992 Ph.D. thesis, "Design and Analysis Techniques for Concurrent Blackboard Systems", John McManus defined several performance metrics for concurrent blackboard systems and developed a suite of tools for creating and analyzing such systems. These tools allow a user to analyze a concurrent blackboard system design and predict the performance of the system before any code is written. The design can be modified until simulated performance is satisfactory. Then, the code generator can be invoked to generate automatically all of the code required for the concurrent blackboard system except for the code implementing the functionality of each knowledge source. We have completed the port of the source code generator and a simulator for a concurrent blackboard system. The source code generator generates the necessary C++ source code to implement the concurrent blackboard system using Parallel Virtual Machine (PVM) running on a heterogeneous network of UNIX(trademark) workstations. The concurrent blackboard simulator uses the blackboard specification file to predict the performance of the concurrent blackboard design. The only part of the source code for the concurrent blackboard system that the user must supply is the code implementing the functionality of the knowledge sources.

Kaplan, J. A.; McManus, J. W.; Bynum, W. L.

1999-01-01

15

[Thymic cancer effectively treated by combination chemotherapy of carboplatin and etoposide with concurrent radiotherapy].  

PubMed

A 63-year-old man was admitted to our hospital for acute heart failure. A chest CT scan revealed a large anterior mediastinal mass and pericardial effusion. Percutaneous needle biopsy showed that the mass was an advanced thymic cancer (squamous cell carcinoma). The patient was treated by combination chemotherapy of carboplatin and etoposide with concurrent radiotherapy (44 Gy). There was no severe toxicity except for grade 4 neutropenia. After 3 courses of chemotherapy, the mass showed an approximately 81% reduction in tumor size and disappearance of the pericardial effusion. Finally, the thymic cancer and small pulmonary metastatic lesions were all resected. This concurrent chemoradiotherapy can be effective against inoperable squamous cell carcinoma of the thymus. PMID:16282742

Kaira, Kyoichi; Watanabe, Rieko; Takise, Atsushi; Endou, Katsuaki; Kamiyoshihara, Mitsuhiro; Mori, Masatomo

2005-11-01

16

Acute Esophagus Toxicity in Lung Cancer Patients After Intensity Modulated Radiation Therapy and Concurrent Chemotherapy  

SciTech Connect

Purpose: The purpose of this study was to investigate the dose-effect relation between acute esophageal toxicity (AET) and the dose-volume parameters of the esophagus after intensity modulated radiation therapy (IMRT) and concurrent chemotherapy for patients with non-small cell lung cancer (NSCLC). Patients and Methods: One hundred thirty-nine patients with inoperable NSCLC treated with IMRT and concurrent chemotherapy were prospectively analyzed. The fractionation scheme was 66 Gy in 24 fractions. All patients received concurrently a daily dose of cisplatin (6 mg/m Superscript-Two ). Maximum AET was scored according to Common Toxicity Criteria 3.0. Dose-volume parameters V5 to V70, D{sub mean} and D{sub max} of the esophagus were calculated. A logistic regression analysis was performed to analyze the dose-effect relation between these parameters and grade {>=}2 and grade {>=}3 AET. The outcome was compared with the clinically used esophagus V35 prediction model for grade {>=}2 after radical 3-dimensional conformal radiation therapy (3DCRT) treatment. Results: In our patient group, 9% did not experience AET, and 31% experienced grade 1 AET, 38% grade 2 AET, and 22% grade 3 AET. The incidence of grade 2 and grade 3 AET was not different from that in patients treated with CCRT using 3DCRT. The V50 turned out to be the most significant dosimetric predictor for grade {>=}3 AET (P=.012). The derived V50 model was shown to predict grade {>=}2 AET significantly better than the clinical V35 model (P<.001). Conclusions: For NSCLC patients treated with IMRT and concurrent chemotherapy, the V50 was identified as most accurate predictor of grade {>=}3 AET. There was no difference in the incidence of grade {>=}2 AET between 3DCRT and IMRT in patients treated with concurrent chemoradiation therapy.

Kwint, Margriet [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Uyterlinde, Wilma [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Nijkamp, Jasper; Chen, Chun; Bois, Josien de; Sonke, Jan-Jakob [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Heuvel, Michel van den [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Thoracic Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Knegjens, Joost; Herk, Marcel van [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Belderbos, Jose, E-mail: j.belderbos@nki.nl [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)] [Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

2012-10-01

17

Modification of the effects of continuous low dose rate irradiation by concurrent chemotherapy infusion  

SciTech Connect

The combined effects of continuous low dose rate irradiation (CLDRI) and concurrent infusion of bleomycin, cyclophosphamide, cis-platinum, 5-fluorouracil, actinomycin D, and mitomycin C were studied in the SCC VII/SF tumor, a squamous cell carcinoma and the jejunal crypt cells in the mouse. For the SCC VII/SF tumor, enhanced cell killing was seen with each of the six drugs when infused concurrently with CLDRI; the greatest enhancement was seen with mitomycin C and cis-platinum. For the jejunal crypt cells, enhanced cell killing was seen primarily with bleomycin. The authors results suggest a therapeutic gain with concurrent CLDRI and chemotherapy infusion for five of the six chemotherapeutic drugs studied with the exception of bleomycin.

Fu, K.K.; Rayner, P.A.; Lam, K.N.

1984-08-01

18

Specifying the behavior of concurrent systems  

NASA Technical Reports Server (NTRS)

A framework for rigorously specifying the behavior of concurrent systems is proposed. It is based on the view of a concurrent system as a collection of interacting processes but no assumptions are made about the mechanisms for process synchronization and communication. A formal language is described that permits the expression of a broad range of logical and timing dependencies.

Furtek, F. C.

1984-01-01

19

The rapid uptake of concurrent chemotherapy for cervix cancer patients treated with curative radiation  

SciTech Connect

Purpose: In 1999, a series of clinical trials along with a clinical announcement from the National Cancer Institute (NCI) suggested that chemotherapy should be used concurrently with pelvic radiation in the management of cervical cancer. The purpose of this study is to examine the rate of chemotherapy use, in the province of Ontario, before and after these publications. Methods: All incident cases of cervix cancer diagnosed between January 1, 1995, and March 31, 2001, were identified using the provincial cancer registry. These records were electronically linked to billing claims data and inpatient discharge abstract data. Patients receiving brachytherapy within 6 months of diagnosis were identified. The proportion receiving at least one injection of chemotherapy before brachytherapy was identified and compared in the 'pre' and 'post' publication group (April 1, 1999, cutoff). Results: We identified 1039 cases as receiving curative radiation. In the pre cohort, 9.4% of patients received chemotherapy (95% CI, 7.3-11.4%) vs. 67.4% in the post cohort (95% CI, 61.8-73.0%). The change occurred abruptly in the first quarter of 1999. Conclusion: There was a significant increase in chemotherapy use after the publication of the NCI alert and related trials. Reasons for rapid uptake are discussed.

Barbera, Lisa [Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada) and Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada) and Institute for Clinical Evaluative Studies, Toronto, Ontario (Canada)]. E-mail: lisa.barbera@sw.ca; Paszat, Lawrence [Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Institute for Clinical Evaluative Studies, Toronto, Ontario (Canada); Thomas, Gillian [Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Covens, Al [Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario (Canada); Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario (Canada); Fyles, Anthony [Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Princess Margaret Hospital, University Health Network, Toronto, Ontario (Canada); Elit, Laurie [Hamilton Regional Cancer Centre, Hamilton, Ontario (Canada); Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario (Canada); Qiu Feng [Institute for Clinical Evaluative Studies, Toronto, Ontario (Canada)

2006-04-01

20

High-dose Helical Tomotherapy With Concurrent Full-dose Chemotherapy for Locally Advanced Pancreatic Cancer  

SciTech Connect

Purpose: To improve poor therapeutic outcome of current practice of chemoradiotherapy (CRT), high-dose helical tomotherapy (HT) with concurrent full-dose chemotherapy has been performed on patients with locally advanced pancreatic cancer (LAPC), and the results were analyzed. Methods and Materials: We retrospectively reviewed 39 patients with LAPC treated with radiotherapy using HT (median, 58.4 Gy; range, 50.8-59.9 Gy) and concomitant chemotherapy between 2006 and 2009. Radiotherapy was directed to the primary tumor with a 0.5-cm margin without prophylactic nodal coverage. Twenty-nine patients (79%) received full-dose (1000 mg/m{sup 2}) gemcitabine-based chemotherapy during HT. After completion of CRT, maintenance chemotherapy was administered to 37 patients (95%). Results: The median follow-up was 15.5 months (range, 3.4-43.9) for the entire cohort, and 22.5 months (range, 12.0-43.9) for the surviving patients. The 1- and 2-year local progression-free survival rates were 82.1% and 77.3%, respectively. Eight patients (21%) were converted to resectable status, including 1 with a pathological complete response. The median overall survival and progression-free survival were 21.2 and 14.0 months, respectively. Acute toxicities were acceptable with no gastrointestinal (GI) toxicity higher than Grade 3. Severe late GI toxicity ({>=}Grade 3) occurred in 10 patients (26%); 1 treatment-related death from GI bleeding was observed. Conclusion: High-dose helical tomotherapy with concurrent full-dose chemotherapy resulted in improved local control and long-term survival in patients with LAPC. Future studies are needed to widen the therapeutic window by minimizing late GI toxicity.

Chang, Jee Suk [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)] [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Wang, Michael L.C. [Department of Radiation Oncology, National Cancer Centre (Singapore)] [Department of Radiation Oncology, National Cancer Centre (Singapore); Koom, Woong Sub; Yoon, Hong In; Chung, Yoonsun [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)] [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of); Song, Si Young [Department of Internal Medicine, Yonsei University College of Medicine, Seoul (Korea, Republic of)] [Department of Internal Medicine, Yonsei University College of Medicine, Seoul (Korea, Republic of); Seong, Jinsil, E-mail: jsseong@yuhs.ac [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)] [Department of Radiation Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)

2012-08-01

21

Phase I/II study of induction chemotherapy plus concurrent chemotherapy and SMART-IMRT-based radiotherapy in locoregionally-advanced nasopharyngeal cancer  

PubMed Central

This study aimed to evaluate the efficacy, toxicity and tolerability of simultaneous modulated accelerated radiation therapy (SMART)-intensity modulated radiotherapy (IMRT) plus cisplatin and 5-fluorouracil (5-FU) chemotherapy for patients with advanced nasopharyngeal cancer (NPC). Forty-five patients with stage II–IV NPC, determined by the American Joint Committee on Cancer system, were treated with prescribed doses of 72 Gy total to the gross tumor volume, 60 Gy to the clinical target volume and metastatic nodal station, and 54 Gy to the clinically-negative neck region. Before radiotherapy, two cycles of cisplatin (30 mg/m2/day on days 1–3) plus 5-FU (400 mg/m2/day on days 1–5) were delivered every three weeks for two cycles. Patients received two cycles of cisplatin (30 mg/m2 day on days 1–3) every three weeks during radiotherapy. In addition, two cycles of cisplatin and 5-FU were given after radiation. All patients completed the prescribed radiotherapy and all scheduled cycles of chemotherapy. Thirty of the 45 patients (66.6%) had a complete response at the end of treatment. Grade 3 mucositis occurred in 4/45 patients (8.8%) and grade 3 dermatitis occurred in 5/45 (11.1%) during radiotherapy. Grade 3 neutropenia occurred in 6/45 (13.3%) during concurrent chemotherapy. There was no treatment-related mortality. After a median follow-up time of 51 months, only three patients’ treatments had failed. Local and distant failure rates were 1.5 and 3.0%, respectively. SMART-IMRT plus cisplatin and 5-FU chemotherapy showed promising activity with manageable toxicity. It is a feasible regimen and improves locoregional disease control.

FAN, TING-YONG; XING, JUN; LU, JIE; LIU, TONG-HAI; XU, MIN; ZHANG, YING-JIE; SHAO, QIAN; LI, JIAN-BIN; YU, JIN-MING

2013-01-01

22

Phase II Study of Consolidation Chemotherapy After Concurrent Chemoradiation in Cervical Cancer: Preliminary Results  

SciTech Connect

Purpose: Our aim was to determine the efficacy of consolidation chemotherapy after concurrent chemoradiation (CCRT) using high-dose-rate brachytherapy in patients with locally advanced cervical carcinoma. Methods and Materials: Patients with cervical carcinoma (FIGO stage IB2-IVA) were treated with external beam radiation therapy to the whole pelvis (50.4 Gy) and high-dose-rate brachytherapy (24 Gy to point A). Cisplatin 60 mg/m{sup 2} (Day 1) and 5-fluorouracil 1000 mg/m{sup 2} (Days 1-5) were given every 3 weeks starting concurrently with the radiation and followed by 3 more cycles of consolidation for a total of 6 cycles. Results: Thirty patients (94%) received 3 more cycles of post-CCRT consolidation chemotherapy and were evaluable for the toxicity and efficacy of consolidation. The most common toxicities of Grade 2 or higher were nausea or vomiting (47%) and anemia (33%). Late complications of the rectum and bladder occurred in 13% and 6% of the patients, respectively. The clinical complete response rate was 87% (95% CI, 75%-99%). During a median follow-up of 27 months (range, 6-58 months), 5 patients (17%) had recurrence; the sites of failure were 3 (10%) inside the radiation field and 2 (7%) outside the radiation field. The estimated 3-year progression-free survival rate was 83% (95% CI, 67%-99%) and overall survival rate was 91% (95% CI, 79%-100%). Conclusions: Consolidation chemotherapy after CCRT is well tolerated and effective in patients with locally advanced cervical carcinoma. A prospective randomized trial to compare this treatment strategy with standard CCRT seems to be worthwhile.

Choi, Chel Hun [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Jeong-Won [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Tae-Joong [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Woo Young [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Nam, Hee Rim [Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Byoung-Gie [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)]. E-mail: huna0@naver.com; Huh, Seung Jae [Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Je-Ho [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Bae, Duk-Soo [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2007-07-01

23

Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma  

PubMed Central

Rituximab plus intravenous bolus chemotherapy is a standard treatment for immunocompetent patients with B-cell non-Hodgkin lymphoma (NHL). Some studies have suggested that rituximab is associated with excessive toxicity in HIVassociated NHL, and that infusional chemotherapy may be more effective. We performed a randomized phase 2 trial of rituximab (375 mg/m2) given either concurrently before each infusional etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (EPOCH) chemotherapy cycle or sequentially (weekly for 6 weeks) after completion of all chemotherapy in HIV-associated NHL. EPOCH consisted of a 96-hour intravenous infusion of etoposide, doxorubicin, and vincristine plus oral prednisone followed by intravenous bolus cyclophosphamide given every 21 days for 4 to 6 cycles. In the concurrent arm, 35 of 48 evaluable patients (73%; 95% confidence interval, 58%-85%) had a complete response. In the sequential arm, 29 of 53 evaluable patients (55%; 95% confidence interval, 41%-68%) had a complete response. The primary efficacy endpoint was met for the concurrent arm only. Toxicity was comparable in the 2 arms, although patients with a baseline CD4 count less than 50/?L had a high infectious death rate in the concurrent arm. We conclude that concurrent rituximab plus infusional EPOCH is an effective regimen for HIV-associated lymphoma. This study is registered at http://clinicaltrials.gov as NCT00049036.

Lee, Jeannette Y.; Kaplan, Lawrence D.; Levine, Alexandra M.; Ramos, Juan Carlos; Ambinder, Richard F.; Wachsman, William; Aboulafia, David; Noy, Ariela; Henry, David H.; Von Roenn, Jamie; Dezube, Bruce J.; Remick, Scot C.; Shah, Manisha H.; Leichman, Lawrence; Ratner, Lee; Cesarman, Ethel; Chadburn, Amy; Mitsuyasu, Ronald

2010-01-01

24

A simple approach to specifying concurrent systems  

Microsoft Academic Search

Over the past few years, I have developed an approach to the formal specification of concurrent systems that I now call the transition axiom method. The basic formalism has already been described in [12] and [1], but the formal details tend to obscure the important concepts. Here, I attempt to explain these concepts without discussing the details of the underlying

Leslie Lamport

1989-01-01

25

Concurrent Cyclophosphamide, Methotrexate, and 5-Fluorouracil Chemotherapy and Radiotherapy for Early Breast Carcinoma  

SciTech Connect

Purpose: The optimal sequencing of adjuvant chemotherapy (CT) and radiation therapy (RT) in patients with early-stage breast cancer remains unclear. Patients and Methods: We retrospectively compared 485 patients treated with conservative breast surgery and postoperative whole-breast RT and six courses of CMF (cyclophosphamide 600 mg/m{sup 2}, methotrexate 40 mg/m{sup 2}, and 5-fluorouracil 600 mg/m{sup 2}) with 300 patients who received postoperative CMF only and with 509 patients treated with postoperative whole-breast RT only. The mean radiation dose delivered was 50 Gy (range, 46-52 Gy) with standard fractionation. The boost dose was 6-16 Gy according to resection margins and at the discretion of the radiation oncologist. Acute and late RT toxicity were scored using respectively the Radiation Therapy Oncology Group and the Late Effects in Normal Tissues Subjective, Objective, Management and Analytic scale. Results: A slightly higher Grade 2 acute skin toxicity was recorded in the concurrent group (21.2% vs. 11.2% of the RT only group, p < 0.0001). RT was interrupted more frequently in the CMF/RT group respective to the RT group (8.5% vs. 4.1%; p = 0.006). There was no difference in late toxicity between the two groups. All patients in the concurrent group successfully received the planned dose of RT and CT. Local recurrence rate was 7.6% in CT/RT group and 9.8% in RT group; this difference was not statistically significant at univariate analysis (log-rank test p = 0.98). However, at multivariate analysis adjusted also for pathological tumor, pathological nodes, and age, the CT/RT group showed a statistically lower rate of local recurrence (p = 0.04). Conclusions: Whole-breast RT and concurrent CMF are a safe adjuvant treatment in terms of toxicity.

Livi, Lorenzo [Department of Radiotherapy, University of Florence, Florence (Italy)], E-mail: l.livi@dfc.unifi.it; Saieva, Calogero [Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Centre (CSPO), Scientific Institute of Tuscany, Florence (Italy); Borghesi, Simona; Paoletti, Lisa; Meattini, Icro; Rampini, Andrea; Petrucci, Alessia; Scoccianti, Silvia; Paiar, Fabiola [Department of Radiotherapy, University of Florence, Florence (Italy); Cataliotti, Luigi [Department of Surgery, University of Florence, Florence (Italy); Leonulli, Barbara Grilli [Department of Radiotherapy, University of Florence, Florence (Italy); Bianchi, Simonetta [Department of Pathology, University of Florence, Florence (Italy); Biti, Gian Paolo [Department of Radiotherapy, University of Florence, Florence (Italy)

2008-07-01

26

Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study.  

PubMed

Local recurrence represents a significant challenge in the management of patients with glioblastoma multiforme. Salvage treatment options are limited by lack of clinical efficacy. Recent studies have demonstrated a significant response rate and acceptable toxicity with the use of fractionated stereotactic radiosurgery in this patient population. Our primary objective was to determine the efficacy and toxicity of fractionated stereotactic radiosurgery combined with concurrent temozolomide chemotherapy as a salvage treatment for recurrent glioblastoma multiforme. We prospectively collected treatment and outcome data for patients having fractionated stereotactic radiosurgery for locally recurrent glioblastoma multiforme after radical radiotherapy. Eligible patients had a maximum recurrence diameter of 60 mm without causing significant mass effect. The gross tumor volume was defined as the enhancing lesion on an enhanced fine-slice T1 (spin-lattice) magnetic resonance imaging, and a circumferential setup margin of 1 mm was used to define the planning target volume. All patients were treated using robotic radiosurgery with three dose/fractionation schedules ranging from 25 to 35 Gy in five fractions, depending on the maximum tumor diameter. Concurrent temozolomide 75 mg/m(2) was prescribed to all patients. Tumor response was judged using the Macdonald criteria, and toxicity was assessed using the CTCAE (Common Terminology Criteria for Adverse Events). A total of 31 patients were enrolled in this study. The median overall survival was 9 months, and progression-free survival was 7 months. The 6-month progression-free survival was 60% with a 95% confidence interval of 43%-77%. The a priori stratification factor of small tumor diameter was shown to predict overall survival, while time to recurrence was not predictive of progression-free or overall survival. Three patients experienced grade 3 acute toxicity that responded to increased steroid dosing. One patient experienced a grade 4 acute toxicity that did not respond to increased steroids but did respond to anti-angiogenic therapy. Fractionated stereotactic radiosurgery with concurrent temozolomide has shown good short-term clinical and radiologic control with manageable acute toxicity. This regimen appears to provide superior efficacy to either temozolomide or fractionated radiosurgery alone. The results of this study support the continued evaluation of this regimen. PMID:24711705

Greenspoon, Jeffrey Noah; Sharieff, Waseem; Hirte, Holger; Overholt, Andrew; Devillers, Rocco; Gunnarsson, Thorsteinn; Whitton, Anthony

2014-01-01

27

Concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone for the treatment of locally advanced nasopharyngeal carcinoma: a retrospective controlled study  

PubMed Central

Objective We evaluated the survival benefit of providing concurrent chemoradiotherapy (ccrt) plus adjuvant chemotherapy compared with ccrt alone to patients with locally advanced nasopharyngeal carcinoma. Methods This retrospective study included 130 patients with nasopharyngeal carcinoma treated with ccrt plus adjuvant chemotherapy from June 2005 to December 2010. Another 130 patients treated with ccrt alone during the same period were matched on age, sex, World Health Organization histology, T stage, N stage, and technology used for radiotherapy. The endpoints included overall survival, locoregional failure-free survival, distant metastasis failure-free survival, and failure-free survival. Results At a mean follow-up of 42.1 months (range: 8–85 months), the observed hazard ratios for the group receiving ccrt plus adjuvant chemotherapy compared with the group receiving ccrt alone were: for overall survival, 0.77 [95% confidence interval (ci): 0.37 to 1.57]; for locoregional failure-free survival, 1.00 (95% ci: 0.37 to 2.71); for distant metastasis failure-free survival, 1.15 (95% ci: 0.56 to 2.37); and for failure-free survival, 1.26 (95% ci: 0.69 to 2.28). There were no significant differences in survival between the groups. After stratification by disease stage, ccrt plus adjuvant chemotherapy provided a borderline significant benefit for patients with N2–3 disease (hazard ratio: 0.35; 95% ci: 0.11 to 1.06; p = 0.052). Multivariate analyses indicated that only tumour stage was a prognostic factor for overall survival. Conclusions Patients with locally advanced nasopharyngeal carcinoma received no significant survival benefit from the addition of adjuvant chemotherapy to ccrt. However, patients with N2–3 disease might benefit from the addition of adjuvant chemotherapy to ccrt.

Liang, Z.; Zhu, X.; Li, L.; Qu, S.; Liang, X.; Liang, Z.; Su, F.; Li, Y.; Zhao, W.

2014-01-01

28

Phase II Trial of Primary Radiation Therapy and Concurrent Chemotherapy for Patients with Locally Advanced Pancreatic Cancer  

Microsoft Academic Search

Objectives: Primary chemoradiotherapy for locally advanced pancreatic cancer (LAPC) may improve local control, curative resection rate and long-term survival. We performed a phase II study to evaluate toxicity and activity of primary radiation therapy and concurrent chemotherapy with gemcitabine (GEM) twice weekly in patients (pts) with LAPC. Methods: From 6\\/1999 to 6\\/2003, 23 LAPC pts received GEM 100 mg\\/m2 twice

A. Magnino; M. Gatti; P. Massucco; E. Sperti; R. Faggiuolo; D. Regge; L. Capussotti; P. Gabriele; M. Aglietta

2005-01-01

29

Concurrent Radiotherapy and Gemcitabine for Unresectable Pancreatic Adenocarcinoma: Impact of Adjuvant Chemotherapy on Survival  

SciTech Connect

Purpose: To retrospectively analyze results of concurrent chemoradiotherapy (CCRT) using gemcitabine (GEM) for unresectable pancreatic adenocarcinoma. Methods and Materials: Records of 108 patients treated with concurrent external beam radiotherapy (EBRT) and GEM were reviewed. The median dose of EBRT in all 108 patients was 50.4 Gy (range, 3.6-60.8 Gy), usually administered in conventional fractionations (1.8-2 Gy/day). During radiotherapy, most patients received GEM at a dosage of 250 to 350 mg/m{sup 2} intravenously weekly for approximately 6 weeks. After CCRT, 59 patients (54.6%) were treated with adjuvant chemotherapy (AC), mainly with GEM. The median follow-up for all 108 patients was 11.0 months (range, 0.4-37.9 months). Results: Initial responses after CCRT for 85 patients were partial response: 26 patients, no change: 51 patients and progressive disease: 8 patients. Local progression was observed in 35 patients (32.4%), and the 2-year local control (LC) rate in all patients was 41.9%. Patients treated with total doses of 50 Gy or more had significantly more favorable LC rates (2-year LC rate, 42.9%) than patients treated with total doses of less than 50 Gy (2-year LC rate, 29.6%). Regional lymph node recurrence was found in only 1 patient, and none of the 57 patients with clinical N0 disease had regional lymph node recurrence. The 2-year overall survival (OS) rate and the median survival time in all patients were 23.5% and 11.6 months, respectively. Patients treated with AC had significantly more favorable OS rates (2-year OS, 31.8%) than those treated without AC (2-year OS, 12.4%; p < 0.0001). On multivariate analysis, AC use and clinical T stage were significant prognostic factors for OS. Conclusions: CCRT using GEM yields a relatively favorable LC rate for unresectable pancreatic adenocarcinoma, and CCRT with AC conferred a survival benefit compared to CCRT without AC.

Ogawa, Kazuhiko, E-mail: kogawa@med.u-ryukyu.ac.jp [Department of Radiology, University of the Ryukyus, Okinawa (Japan); Ito, Yoshinori [Department of Radiation Oncology, National Cancer Center, Tokyo (Japan); Hirokawa, Naoki [Department of Radiology, Sapporo Medical University, Sapporo (Japan); Shibuya, Keiko [Department of Radiation Oncology and Image-Applied Therapy, Kyoto University, Kyoto (Japan); Kokubo, Masaki [Department of Radiation Oncology, Institute of Biomedical Research and Innovation Hospital, Kobe (Japan); Ogo, Etsuyo [Department of Radiation Oncology, Kurume University, Kurume (Japan); Shibuya, Hitoshi [Department of Radiology, Tokyo Medical and Dental University, Tokyo (Japan); Saito, Tsutomu [Department of Radiation Oncology, Nihon University Itabashi Hospital, Tokyo (Japan); Onishi, Hiroshi [Department of Radiology, Yamanashi University, Yamanashi (Japan); Karasawa, Katsuyuki [Department of Radiation Oncology, Tokyo Metropolitan Komagome Hospital, Tokyo (Japan); Nemoto, Kenji [Department of Radiation Oncology, Yamagata University, Yamagata (Japan); Nishimura, Yasumasa [Department of Radiation Oncology, Kinki University School of Medicine, Osaka (Japan)

2012-06-01

30

Salivary Gland Tumors Treated With Adjuvant Intensity-Modulated Radiotherapy With or Without Concurrent Chemotherapy  

SciTech Connect

Purpose: To analyze the recent single-institution experience of patients with salivary gland tumors who had undergone adjuvant intensity-modulated radiotherapy (IMRT), with or without concurrent chemotherapy. Patients and Methods: We performed a retrospective analysis of 35 salivary gland carcinoma patients treated primarily at the Dana-Farber Cancer Institute between 2005 and 2010 with surgery and adjuvant IMRT. The primary endpoints were local control, progression-free survival, and overall survival. The secondary endpoints were acute and chronic toxicity. The median follow-up was 2.3 years (interquartile range, 1.2-2.8) among the surviving patients. Results: The histologic types included adenoid cystic carcinoma in 15 (43%), mucoepidermoid carcinoma in 6 (17%), adenocarcinoma in 3 (9%), acinic cell carcinoma in 3 (9%), and other in 8 (23%). The primary sites were the parotid gland in 17 (49%), submandibular glands in 6 (17%), tongue in 4 (11%), palate in 4 (11%), and other in 4 (11%). The median radiation dose was 66 Gy, and 22 patients (63%) received CRT. The most common chemotherapy regimen was carboplatin and paclitaxel (n = 14, 64%). A trend was seen for patients undergoing CRT to have more adverse prognostic factors, including Stage T3-T4 disease (CRT, n = 12, 55% vs. n = 4, 31%, p = .29), nodal positivity (CRT, n = 8, 36% vs. n = 1, 8%, p = .10), and positive margins (n = 13, 59% vs. n = 5, 38%, p = .30). One patient who had undergone CRT developed an in-field recurrence, resulting in an overall actuarial 3-year local control rate of 92%. Five patients (14%) developed distant metastases (1 who had undergone IMRT only and 4 who had undergone CRT). Acute Grade 3 mucositis, esophagitis, and dermatitis occurred in 8%, 8%, and 8% (1 each) of IMRT patients and in 18%, 5%, and 14% (4, 1, and 3 patients) of the CRT group, respectively. No acute Grade 4 toxicity occurred. The most common late toxicity was Grade 1 xerostomia (n = 8, 23%). Conclusions: Treatment of salivary gland malignancies with postoperative IMRT was well tolerated with a high rate of local control. Chemoradiotherapy resulted in excellent local control in a subgroup of patients with adverse prognostic factors and might be warranted in select patients.

Schoenfeld, Jonathan D., E-mail: jdschoenfeld@partners.org [Department of Radiation Oncology, Harvard Radiation Oncology Program, Boston, MA (United States); Sher, David J. [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States); Norris, Charles M. [Department of Surgery, Division of Otolaryngology, Brigham and Women's Hospital, Boston, MA (United States); Haddad, Robert I.; Posner, Marshall R. [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Department of Medicine, Brigham and Women's Hospital, Boston, MA (United States); Balboni, Tracy A.; Tishler, Roy B. [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA (United States)

2012-01-01

31

Concurrency control in trusted database management systems: a survey  

Microsoft Academic Search

Recently several algorithms have been proposed for concurrency control in a Trusted Database Management System (TDBMS). The various research efforts are examining the concurrency control algorithms developed for DBMSs and adapting them for a multilevel environment. This paper provides a survey of the concurrency control algorithms for a TDBMS and discusses future directions.

Bhavani M. Thuraisingham; Hai-Ping Ko

1993-01-01

32

Integrating Concurrency Control into an Object-Oriented Database System  

Microsoft Academic Search

In this paper, we describe the problems involved in integrating concurrency control into object-oriented database systems. The object-oriented approach places specific constraints on concurrency between transactions, which we discuss. We then propose an adaptation of the locking technique to satisfy them, without unnecessarily restricting concurrency. Finally, we analyse in detail the impacts of both the transaction model and the locking

Michèle Cart; Jean Ferrié

1990-01-01

33

Topotecan and ifosfamide systemic chemotherapy for CNS involvement of solid tumors  

Microsoft Academic Search

The prognosis of patients with CNS involvement of solid tumors is poor. In these patients, systemic chemotherapy has a theoretical\\u000a advantage of concurrent treatment of systemic disease and reduced risk of neurotoxicity. Here, we report on the efficacy and\\u000a toxicity of topotecan\\/ifosfamide (TOPO\\/IFO) combination chemotherapy in patients treated for CNS involvement of different\\u000a solid malignancies. Fourteen patients with CNS manifestations

Philipp Kiewe; Eckhard Thiel; Mark Reinwald; Agnieszka Korfel

2011-01-01

34

Prospective Pilot Study of Consolidation Chemotherapy With Docetaxel and Cisplatin After Concurrent Chemoradiotherapy for Advanced Head and Neck Cancer  

SciTech Connect

Purpose: With the improvement concurrent chemoradiotherapy (CCRT) in the management of patients with locoregionally advanced head and neck squamous cell carcinoma (HNSCC), distant failures have become a more relevant problem in terms of survival. The primary objective of this Phase II study is to assess the feasibility of docetaxel and cisplatin consolidation after primary CCRT for patients with HNSCC. Methods and Materials: Patients with locoregionally advanced HNSCC received chemotherapy with three cycles of cisplatin, 100 mg/m{sup 2}, on Days 1, 22, and 43. Concurrent radiotherapy to the primary tumor and neck was given in a daily dose of 2 Gy to a total dose of 70-70.2 Gy over 7 weeks. After completion of CCRT, patients without evidence of disease progression received an additional four cycles of consolidation chemotherapy with docetaxel, 75 mg/m{sup 2}, and cisplatin, 75 mg/m{sup 2}, every 3 weeks. Results: Of 33 patients, 27 (81%) completed CCRT. After CCRT, three complete and 19 partial responses were recorded, giving an overall response rate of 67%. Of 19 patients who went to the consolidation phase, only 4 (21%) received all four cycles of docetaxel and cisplatin. Causes of failure of consolidation chemotherapy were toxicity in 11 patients, including three treatment-related deaths, and progression in 4 patients. Three patients died of sepsis during the consolidation phase. Median survival was 11 months for all patients and 8 months for those treated with consolidation chemotherapy. Conclusion: The poor compliance and high incidence of severe toxicities prompted no further evaluation of this consolidation chemotherapy after CCRT.

Lee, Kyun Chan; Lee, Seok Ho [Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Lee, Yuna [Department of Internal Medicine, Division of Hematology and Oncology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Park, Se Hoon [Department of Internal Medicine, Division of Hematology and Oncology, Gachon University Gil Medical Center, Incheon (Korea, Republic of)], E-mail: hematoma@gilhospital.com; Park, Jinny; Cho, Eun Kyung; Shin, Dong Bok; Lee, Jae Hoon [Department of Internal Medicine, Division of Hematology and Oncology, Gachon University Gil Medical Center, Incheon (Korea, Republic of); Kim, Dong Young; Kim, Seon Tae [Department of Otolaryngology, Gachon University Gil Medical Center, Incheon (Korea, Republic of)

2008-05-01

35

Concurrent vs Sequential Adjuvant Chemotherapy and Hormone Therapy in Breast Cancer: A Multicenter Randomized Phase III Trial  

PubMed Central

Background The most appropriate timing of chemotherapy and hormone therapy administration is a critical issue in early breast cancer patients. The purpose of our study was to compare the efficacy of concurrent vs sequential administration of adjuvant chemotherapy and tamoxifen. Methods Women with node-positive primary breast cancer were randomly assigned to receive tamoxifen (20 mg/d for 5 years) during (concurrent arm) or after (sequential arm) adjuvant chemotherapy. Chemotherapy consisted of alternating regimens of cyclophosphamide, epidoxorubicin, and 5-fluorouracil and cyclophosphamide, methotrexate, and 5-fluorouracil every 21 days for a total of 12 cycles. The primary endpoint was overall survival (OS), and secondary endpoints were toxic effects and disease-free survival (DFS). No provision for interim analyses was made in the original study protocol. Survival curves were estimated by the Kaplan–Meier method. Multivariable Cox regression models, adjusted for age, menopausal status, tumor stage, and lymph node and hormone receptor status, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results From 1985 to 1992, 431 patients were randomly assigned and studied according to the intention-to-treat principle. After a maximum of 15.4 years of follow-up (median 12.3 years), the estimated actuarial 10-year OS was equivalent for the two study arms (concurrent arm: 111 patients, 66%, 95% CI = 59% to 72%; sequential arm: 114 patients, 65%, 95% CI = 59% to 72%, P = .86). No differences in DFS and toxic effects were evident. Four interim analyses were performed, but no alpha error adjustment was necessary because of the largely negative results of this final analysis (sequential vs concurrent arm: HR of death = 1.06, 95% CI = 0.78 to 1.44, P = .76; HR of relapse = 1.16, 95% CI = 0.88 to 1.52, P = .36). Conclusions No statistically significant differences in OS, DFS, and toxic effects between concurrent and sequential adjuvant chemo- and hormone therapies were observed. Our study does not support the superiority of one schedule of chemo- and hormone-therapy administration over the other. However, because of the limited statistical power of the study, these results must be considered with caution.

Sertoli, Mario Roberto; Pronzato, Paolo; Del Mastro, Lucia; Venturini, Marco; Taveggia, Paola; Zanardi, Elisa; Siffredi, Guido; Pastorino, Simona; Queirolo, Paola; Gardin, Giovanni; Wang, Ena; Monzeglio, Clara; Boccardo, Francesco; Bruzzi, Paolo

2011-01-01

36

Anthracycline-based induction chemotherapy followed by concurrent cyclophosphamide, methotrexate and 5-fluorouracil and radiation therapy in surgically resected axillary node-positive breast cancer  

PubMed Central

The present study aimed to determine the toxicity and efficacy of 4 courses of anthracyclines-taxane (AT) chemotherapy followed by radiation therapy (XRT) concurrent with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in surgically resected axillary node-positive (N+) breast cancer. A total of 200 women with N+ breast cancer were treated with adriamycin and docetaxel followed by XRT concurrent with six courses of CMF. Two courses of dose-dense chemotherapy with ifosfamide, carboplatin and etoposide, supported by pegfilgrastim, were administered to patients with >5 histologically confirmed axillary lymph node metastases and patients with triple-negative disease. Additional treatments included 1 year of trastuzumab in human epidermal growth factor receptor 2-positive patients, 5 years of a luteinizing hormone-releasing hormone analogue in premenopausal women and 5 years of an aromatase inhibitor (AI) in estrogen receptor-positive (ER+) patients. The mean number of positive axillary lymph nodes was 4.4 (range, 2–37), 52% of the patients were premenopausal, 74% were ER+ and 26% had triple-negative disease. After a median follow-up of 73 months, grade 2 and 3 hematological toxicity was observed in 20% of the patients. The 10-year disease-free survival (DFS) and overall survival (OS) rates were 73 and 77%, respectively. There was no significant difference in DFS between ER+ and estrogen receptor-negative (ER?) patients (P>0.05), whereas the OS was better in ER+ vs. ER? patients (P<0.05) and in premenopausal vs. postmenopausal patients (P<0.005). In conclusion, induction AT concurrent CMF and XRT and dose-dense chemotherapy followed by AI in N+ high-risk breast cancer was associated with a low level of systemic and late cardiac toxicity and excellent local control, DFS and OS.

RECCHIA, FRANCESCO; CANDELORO, GIAMPIERO; CESTA, ALISIA; DI STASO, MARIO; BONFILI, PIERLUIGI; GRAVINA, GIOVANNI LUCA; DI CESARE, ERNESTO; NECOZIONE, STEFANO; REA, SILVIO

2014-01-01

37

Concurrency Control in Distributed Database Systems  

Microsoft Academic Search

In this paper we survey, consolidate, and present the state of the art in distributed database concurrency control. The heart of our analysts is a decomposition of the concurrency control problem into two major subproblems: read-write and write-write synchronization. We describe a series of synchromzation techniques for solving each subproblem and show how to combine these techniques into algorithms for

Philip A. Bernstein; Nathan Goodman

1981-01-01

38

Maintainability Analysis in Concurrent Engineering of Mechanical Systems  

Microsoft Academic Search

Maintainability of the mechanical system should be considered from early stages of the design process to reduce its total life-cycle cost A computer-aided engineering environment that supports maintainability analysis of an evolving mechanical system design in a concurrent engineering environment is presented Its communication with the underlying concurrent engineering environment and capabilities to evaluate maintainability of the mechanical system are

Ranko Vujosevic

1995-01-01

39

System level concurrency control for distributed database systems  

Microsoft Academic Search

A distributed database system is one in which the database is spread among several sites and application programs “move” from site to site to access and update the data they need. The concurrency control is that portion of the system that responds to the read and write requests of the application programs. Its job is to maintain the global consistency

Daniel J. Rosenkrantz; Richard Edwin Stearns; Philip M. Lewis II

1978-01-01

40

A Matched-Case Comparison to Explore the Role of Consolidation Chemotherapy After Concurrent Chemoradiation in Cervical Cancer  

SciTech Connect

Purpose: The aim of this study was to compare the efficacy and toxicity of consolidation chemotherapy after concurrent chemoradiation (CCRT) and CCRT alone in patients with locally advanced cervical carcinoma. Methods and Materials: Using medical records from January 2001 to December 2007, 39 patients treated with consolidation chemotherapy after CCRT (Group 1) were matched to 39 patients treated with CCRT alone (Group 2). Consolidation chemotherapy consisted of three additional cycles of chemotherapy with cisplatin 60 mg/m{sup 2} (Day 1) and 5-fluorouracil 1,000 mg/m{sup 2} per day (Days 1-5) given every 3 weeks. The primary endpoint was overall survival. Results: During a median follow-up period of 35 months (range, 8-96 months), 10 (25.6%) and 16 (41.0%) patients showed disease progression in Groups 1 and 2, respectively. Distant recurrence with or without locoregional/lymphogenous recurrence occurred more frequently in Group 2 than in Group 1 (23.1% vs. 7.7%, p = 0.06). By contreast, there was no difference in locoregional or lymphogenous recurrence between the two groups. The rate of overall survival was higher in Group 1 than in Group 2 (92.7% vs. 69.9%, p = 0.042), whereas the difference in progression-free survival between the groups was not statistically significant (70.1% vs. 55.1%, p = 0.079). Although the difference was not statistically significant, neutropenia was more common in Group 1 than in Group 2 (10.9% vs. 4.7%, p = 0.07). Conclusions: Consolidation chemotherapy after CCRT may improve survival and reduce distant recurrence without additional toxicity compared to CCRT alone in patients with locally advanced cervical carcinoma.

Choi, Chel Hun; Lee, Yoo-Young; Kim, Min Kyu; Kim, Tae-Joong; Lee, Jeong-Won [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Nam, Hee Rim; Huh, Seung Jae [Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Je-Ho; Bae, Duk-Soo [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Byoung-Gie, E-mail: bksong.kim@samsung.com [Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2011-12-01

41

A System of Patterns for Concurrent Request Processing Servers  

Microsoft Academic Search

This paper addresses architectures of concurrent request processing servers, which are typically implemented using multitasking capabilities of an underlying operating system. Request processing servers should respond quickly to concurrent requests of an open number of clients without wasting server resources. This paper describes a small sys- tem of patterns for request processing servers, covering a relative wide range of architectures.

Bernhard Gröne; Peter Tabeling

42

Bounded Concurrent Time-Stamp Systems Are Constructible.  

National Technical Information Service (NTIS)

Concurrent time stamping is at the heart of the solutions to some of the most fundamental problems in distributed computing. Based on concurrent-time-stamp-systems, elegant and simple solutions to core problems such as fcfs-mutual-exclusion, construction ...

D. Dolev N. Shavit

1989-01-01

43

Automated Analysis of Concurrent Systems With the Constrained Expression Toolset  

Microsoft Academic Search

The constrained expression approach to analysis of concurrent softwaresystems has several attractive features, including the facts that itcan be used with a variety of design and programming languages and thatit does not require a complete enumeration of the set of reachable statesof the concurrent system. This paper reports on the construction of atoolset automating the main constrained expression analysis techniquesand

George S. Avrunin; Ugo A. Buy; James C. Corbett; Laura K. Dillon; Jack C. Wileden

1991-01-01

44

Verification of Concurrent Programs: A Temporal Proof System.  

National Technical Information Service (NTIS)

A proof system based on temporal logic is presented for proving properties of concurrent programs based on the shared-variables computation model. The system consists of three parts: the general uninterpreted part, the domain dependent part and the progra...

Z. Manna A. Pnueli

1983-01-01

45

Chemotherapy  

MedlinePLUS

... common side effects of chemotherapy are: Vomiting Diarrhea Fatigue Fetal injury Your doctor can provide more information about the specific side effects associated with a particular type of chemotherapy. Potential Risks Like any treatment, chemotherapy carries risks. Some of ...

46

Treatment of Locally Advanced Cervical Cancer with Concurrent Radiation and Intra-arterial Chemotherapy  

Microsoft Academic Search

The purpose of this study was to determine the maximum tolerated dose (MTD) and feasibility of treatment with sequential intra-arterial FUDR and cisplatin administered with concurrent whole pelvis radiation (XRT) to women with advanced cervical cancer. Sixteen patients with squamous carcinoma of the cervix were prospectively treated in a Phase I study. All tumors were stages IIb, IIIb, or IVa

Mitchell Morris; Patricia J. Eifel; Thomas W. Burke; Mary M. McNamara; Charles Levenback; John J. Kavanagh; David M. Gershenson

1995-01-01

47

Radiotherapy With or Without Concurrent Chemotherapy for Lymph Node Recurrence After Radical Surgery of Thoracic Esophageal Squamous Cell Carcinoma  

SciTech Connect

Purpose: To retrospectively compare the outcomes of patients with lymph node recurrence after radical surgery of esophageal cancer, when given radiotherapy with or without concurrent chemotherapy. Methods and Materials: Between January 1996 and December 2005, the data from 73 patients with lymph node recurrence after radical surgery of thoracic esophageal squamous cell carcinoma were retrospectively reviewed. The patients were separated into two groups: radiochemotherapy (RC, 31 patients) and radiotherapy alone (RA, 42 patients). Patients in the RC group received at least two cycles of 5-fluorouracil/cisplatin chemotherapy concurrently with radiotherapy. Results: The median duration of follow-up was 11 months (range, 2-48). The overall survival rate for all patients was 46.7% and 4.7% at 1 and 3 years, respectively. The median overall survival time was 9 months (95% confidence interval, 6.96-11.04) and 17 months (95% confidence interval, 13.61-20.39) for RA and RC groups, respectively. The survival rate at 1 and 3 years was 62.5% and 10.5% in the RC group and 33.8% and 0% in the RA group (p = .0049, log-rank test; hazard ratio for death, 0.52; 95% confidence interval, 0.30-0.92). Acute toxicities were more frequent in the RC group than in the RA group. No significant differences were found in the late toxicity profiles between the two groups. Conclusion: The results of the present retrospective analysis suggest that RC should be considered an effective and well-tolerated treatment of patients with thoracic esophageal squamous cell carcinoma and postoperative lymph node recurrence.

Lu Jincheng, E-mail: lujincheng@msn.co [Department of Radiotherapy, Jiangsu Cancer Hospital, Nanjing (China); Kong Cheng; Tao Hua [Department of Radiotherapy, Jiangsu Cancer Hospital, Nanjing (China)

2010-11-01

48

PACT: An Experiment in Integrating Concurrent Engineering Systems  

Microsoft Academic Search

The Palo Alto Collaborative Testbed (PACT) is a laboratory for joint experimentation incomputer-aided concurrent engineering being pursued by research groups at Stanford University,Lockheed, Hewlett-Packard, and Enterprise Integration Technologies. The current prototypeintegrates four preexisting concurrent engineering systems into a common framework. Eachindividual system is used to model different aspects of a small robotic manipulator, and toreason about them from a different...

Mark R. Cutkosky; Robert S. Engelmore; Richard E. Fikes; Michael R. Genesereth; Thomas R. Gruber; William S. Mark; Jay M. Tenenbaum; Jay C. Weber

1993-01-01

49

Database Concurrency Control in Multilevel Secure Database Management Systems  

Microsoft Academic Search

Concurrent execution of transactions in database management systems (DBMSs) may lead to contention for access to data, which in a multilevel secure DBMS (MLS\\/DBMS) may lead to insecurity. Security issues involved in database concurrency control for MLS\\/DBMSs are examined, and it is shown how a scheduler can affect security. Data conflict security, (DC-security), a property that implies a system is

Thomas F. Keefe; Wei-tek Tsai; Jaideep Srivastava

1993-01-01

50

A Concurrent Distributed System for Aircraft Tactical Decision Generation  

NASA Technical Reports Server (NTRS)

A research program investigating the use of artificial intelligence (AI) techniques to aid in the development of a Tactical Decision Generator (TDG) for Within Visual Range (WVR) air combat engagements is discussed. The application of AI programming and problem solving methods in the development and implementation of a concurrent version of the Computerized Logic For Air-to-Air Warfare Simulations (CLAWS) program, a second generation TDG, is presented. Concurrent computing environments and programming approaches are discussed and the design and performance of a prototype concurrent TDG system are presented.

McManus, John W.

1990-01-01

51

Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy  

SciTech Connect

The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerologia de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

Herrera, Higmar; Yanez, Elvia; Lopez, Jesus [Centro Estatal de Cancerologia de Durango, Victoria de Durango, Durango (Mexico); ISSSTE General Hospital Dr. Santiago Ramon y Cajal, Victoria de Durango, Durango (Mexico)

2012-10-23

52

A Phase II Study of Radiotherapy and Concurrent Paclitaxel Chemotherapy in Breast-Conserving Treatment for Node-Positive Breast Cancer  

SciTech Connect

Purpose: Administering adjuvant chemotherapy before breast radiotherapy decreases the risk of systemic recurrence, but delays in radiotherapy could yield higher local failure. We assessed the feasibility and efficacy of placing radiotherapy earlier in the breast-conserving treatment course for lymph node-positive breast cancer. Methods and Materials: Between June 2000 and December 2004, 44 women with node-positive Stage II and III breast cancer were entered into this trial. Breast-conserving surgery and 4 cycles of doxorubicin (60 mg/m{sup 2})/cyclophosphamide (600 mg/m{sup 2}) were followed by 4 cycles of paclitaxel (175 mg/m{sup 2}) delivered every 3 weeks. Radiotherapy was concurrent with the first 2 cycles of paclitaxel. The breast received 39.6 Gy in 22 fractions with a tumor bed boost of 14 Gy in 7 fractions. Regional lymphatics were included when indicated. Functional lung volume was assessed by use of the diffusing capacity for carbon monoxide as a proxy. Breast cosmesis was evaluated with the Harvard criteria. Results: The 5-year actuarial rate of disease-free survival is 88%, and overall survival is 93%. There have been no local failures. Median follow-up is 75 months. No cases of radiation pneumonitis developed. There was no significant change in the diffusing capacity for carbon monoxide either immediately after radiotherapy (p = 0.51) or with extended follow-up (p = 0.63). Volume of irradiated breast tissue correlated with acute cosmesis, and acute Grade 3 skin toxicity developed in 2 patients. Late cosmesis was not adversely affected. Conclusions: Concurrent paclitaxel chemotherapy and radiotherapy after breast-conserving surgery shortened total treatment time, provided excellent local control, and was well tolerated.

Chen, William C. [Department of Radiation Oncology, University Hospitals Case Medical Center, Cleveland, OH (United States); Kim, Janice [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA (United States); Kim, Edward [Department of Radiation Oncology, Ohio State University Medical Center, Columbus, OH (United States); Silverman, Paula [Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH (United States); Overmoyer, Beth [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Cooper, Brenda W. [Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH (United States); Anthony, Sue [Department of Radiation Oncology, University Hospitals Case Medical Center, Cleveland, OH (United States); Shenk, Robert; Leeming, Rosemary [Department of Surgery, University Hospitals Case Medical Center, Cleveland, OH (United States); Hanks, Shelli H. [Arizona Institute of Urology, Tucson, AZ (United States); Lyons, Janice A., E-mail: janice.lyons@uhhospitals.org [Department of Radiation Oncology, University Hospitals Case Medical Center, Cleveland, OH (United States)

2012-01-01

53

Granularity of modules in object-based concurrent systems  

Microsoft Academic Search

We examine the interaction of abstraction, distribution, and synchronization in determining the granularity of modules in object-based concurrent systems. The relation between linearizability and serializability as correctness criteria for processes with internal concurrency is explored.Module granularity in object-based programming languages depends on the following factors:the abstraction boundary (unit of encapsulation) the information-hiding interface a module presents to its users or

Peter Wegner

1989-01-01

54

Early Clinical Outcome With Concurrent Chemotherapy and Extended-Field, Intensity-Modulated Radiotherapy for Cervical Cancer  

SciTech Connect

Purpose: To assess the early clinical outcomes with concurrent cisplatin and extended-field intensity-modulated radiotherapy (EF-IMRT) for carcinoma of the cervix. Methods and Materials: Thirty-six patients with Stage IB2-IVA cervical cancer treated with EF-IMRT were evaluated. The pelvic lymph nodes were involved in 19 patients, and of these 19 patients, 10 also had para-aortic nodal disease. The treatment volume included the cervix, uterus, parametria, presacral space, upper vagina, and pelvic, common iliac, and para-aortic nodes to the superior border of L1. Patients were assessed for acute toxicities according to the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 3.0. All late toxicities were scored with the Radiation Therapy Oncology Group late toxicity score. Results: All patients completed the prescribed course of EF-IMRT. All but 2 patients received brachytherapy. Median length of treatment was 53 days. The median follow-up was 18 months. Acute Grade {>=}3 gastrointestinal, genitourinary, and myelotoxicity were seen in 1, 1, and 10 patients, respectively. Thirty-four patients had complete response to treatment. Of these 34 patients, 11 developed recurrences. The first site of recurrence was in-field in 2 patients (pelvis in 1, pelvis and para-aortic in 1) and distant in 9 patients. The 2-year actuarial locoregional control, disease-free survival, overall survival, and Grade {>=}3 toxicity rates for the entire cohort were 80%, 51%, 65%, and 10%, respectively. Conclusion: Extended-field IMRT with concurrent chemotherapy was tolerated well, with acceptable acute and early late toxicities. The locoregional control rate was good, with distant metastases being the predominant mode of failure. We are continuing to accrue a larger number of patients and longer follow-up data to further extend our initial observations with this approach.

Beriwal, Sushil [Department of Radiation Oncology, Pittsburgh, PA (United States)]. E-mail: beriwals@upmc.edu; Gan, Gregory N. [University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Heron, Dwight E. [Department of Radiation Oncology, Pittsburgh, PA (United States); Selvaraj, Raj N. [Department of Radiation Oncology, Pittsburgh, PA (United States); Kim, Hayeon [Department of Radiation Oncology, Pittsburgh, PA (United States); Lalonde, Ron [D3 Advanced Radiation Planning, Pittsburgh, PA (United States); Kelley, Joseph L. [Division of Gynecologic Oncology, Department of Gynecology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Edwards, Robert P. [Division of Gynecologic Oncology, Department of Gynecology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States)

2007-05-01

55

Induction chemotherapy followed by concurrent chemoradiation for patients with non-operable stage III non-small-cell lung cancer.  

PubMed

Combined modality treatment with chemotherapy (CT) and radiotherapy (RT) in stage III non-small-cell lung cancer is considered as standard therapy. As concomitant CT appears to be beneficial, the choice of anticancer agents and the role of induction chemotherapy is still unresolved. We present our experience based on an induction CT scheme with carboplatin plus paclitaxel followed by RT and concomitant CT. 31 patients with non-operable stage IIIA or IIIB NSCLC without pleural effusion were included in this study: 30 males, 1 female; median age 66 years (range: 50-81); 32% with non-operable stage IIIA and 68% with stage IIIB without pleural effusion; 61% squamous cell carcinoma, 32% adenocarcinoma and 7% other histologies. Regarding performance status (PS), 9.7% PS 0 and 90% PS 1 were included. Patients received 3 courses of induction CT with carboplatin AUC=6 and paclitaxel 175 mg/m(2), administrated i.v. on day 1 of each 21-day cycle, followed by thoracic irradiation (total dose 60-65 Gy, daily fractions 1.8-2 Gy) with two concurrent courses of carboplatin/paclitaxel. 16.2% of the patients achieved complete response, 48.4% partial response, 25.8% stable disease and 9.6% progression of disease. Median progression-free and overall survival was 12 and 18 months, respectively. The most frequent haematological toxicities were grade (G) 3 anaemia in 19.3%, G3 neutropenia in 9.6% and G4 neutropenia in 12.9%. Esophageal G2 toxicity (RTOG) was observed in 28.1% of cases. The induction CT followed by concomitant chemoradiation used in this study appears feasible, safe and effective when administered to an unselected inoperable NSCLC stage III patient cohort in the everyday routine clinical practice. Further, our results are comparable to previously published phase III studies. PMID:18550204

Iranzo, Vega; Bremnes, Roy M; Almendros, Piedad; Gavilá, Joaquín; Blasco, Ana; Sirera, Rafael; Camps, Carlos

2009-01-01

56

Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma  

SciTech Connect

Purpose: To define favorable pretreatment characteristics for overall survival (OS), progression-free survival (PFS), locoregional control, and freedom from distant metastasis for patients with recurrent and second primary head-and-neck cancer treated with concomitant chemotherapy and reirradiation. Methods and Materials: Our study population comprised a subset of 115 previously irradiated patients without overt metastases from 304 poor-prognosis head-and-neck cancer patients treated in seven consecutive phase I-II protocols. Of the 115 patients, 49, who had undergone surgical resection, were treated with a median of four cycles of concurrent chemotherapy and reirradiation and 66, who had not undergone surgical resection, were treated with a median of five cycles. The following regimens were used: 5-fluorouracil and hydroxyurea concurrent with reirradiation (FHX) (n = 14), cisplatin plus FHX (n = 23), paclitaxel plus FHX (n = 42), gemcitabine plus paclitaxel and 5-fluorouracil concurrent with reirradiation (n = 26), and irinotecan plus FHX (n = 10). Results: The median lifetime radiation dose was 131 Gy. The median follow-up for surviving patients was 67.4 months (range, 18.5-158.7). The median OS and PFS was 11 and 7 months (range, 0.2-158.7), respectively. The 3-year OS, PFS, locoregional control, and freedom from distant metastasis rate was 22%, 33%, 51%, and 61%, respectively. Multivariate analysis identified reirradiation dose, triple agent (cisplatin-, paclitaxel-, or gemcitabine-containing chemotherapy), and surgery before protocol treatment as independently prognostic for OS, PFS, and locoregional control. Triple-agent chemotherapy was prognostic for freedom from distant metastasis. Nineteen patients died of treatment-related toxicity, five of these of carotid hemorrhage. Conclusion: For recurrent and second primary head-and-neck cancer, trimodality therapy with surgery, concurrent chemotherapy, and reirradiation for a full second dose offers potential for long-term survival. Owing to the substantial toxicity and lack of an optimal regimen, reirradiation of recurrent head-and-neck cancer should be limited to clinical trials.

Salama, Joseph K. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Vokes, Everett E. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Section of Hematology/Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Cancer Research Center, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Chmura, Steven J. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Milano, Michael T. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Kao, Johnny [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Stenson, Kirsten M. [Cancer Research Center, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Section of Otolaryngology/Head and Neck Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Witt, Mary Ellyn R.N. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Haraf, Daniel J. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States) and Cancer Research Center, University of Chicago Pritzker School of Medicine, Chicago, IL (United States)]. E-mail: dharaf@radonc.uchicago.edu

2006-02-01

57

Visual Programming of Concurrent Object-Oriented Systems  

Microsoft Academic Search

In order to be able to understand the functionality of even small concurrent systems, visual and formally based notations for their description are needed. The handling of complex systems additionally demands for notations of- fering adequate structuring capabilities. From a theoreti- cal point of view the combination of Petri-Nets and object- oriented concepts is a promising approach in this area.

Stephan Philippi

2001-01-01

58

Treatment of locally advanced cervical cancer with concurrent radiation and intra-arterial chemotherapy.  

PubMed

The purpose of this study was to determine the maximum tolerated dose (MTD) and feasibility of treatment with sequential intra-arterial FUDR and cisplatin administered with concurrent whole pelvis radiation (XRT) to women with advanced cervical cancer. Sixteen patients with squamous carcinoma of the cervix were prospectively treated in a Phase I study. All tumors were stages IIb, IIIb, or IVa with diameters of > or = 7 cm. Patients underwent surgical staging with pelvic and paraortic lymphadenectomy with placement of bilateral intra-arterial catheters in the anterior division of the internal iliac arteries. The catheters terminated in separate subcutaneous ports. No patient had metastasis in the high common iliac or paraortic nodes. Patients received a planned course of 40-50 Gy whole pelvis XRT followed by indicated brachytherapy. During the first 2 weeks of whole pelvis XRT, patients received a 1-hr infusion of FUDR and during the second 2 weeks a 1-hr infusion of cisplatin, each delivered daily by external pump with the daily whole pelviS XRT fraction. Additional cisplatin was infused during brachytherapy. Five dose levels ranging from 6.5 to 27 mg/m2 daily for FUDR and from 2 to 8 mg/m2 daily for cisplatin were used. The MTD of FUDR and CDDP was dose level 4 (22.5 and 6.75 mg/m2, respectively). Dose-limiting toxicity was grade 3/4 nausea seen in three of four patients at dose level 5. No patient had neuro- or ototoxicity. There was no grade 4 myelosuppression. Eight patients had a complete response, and six had a partial response. Disease progressed in two. Mean follow-up was 22.4 months. At this writing, 10 patients had no evidence of disease, 2 were alive with disease, and 4 had died of disease. Median survival has not been reached. This is a well-tolerated regimen with significant activity that warrants further investigation at dose level 4. PMID:7705704

Morris, M; Eifel, P J; Burke, T W; McNamara, M M; Levenback, C; Kavanagh, J J; Gershenson, D M

1995-04-01

59

Phase II Selection Design Trial of Concurrent Chemotherapy and Cetuximab Versus Chemotherapy Followed by Cetuximab in Advanced-Stage Non-Small-Cell Lung Cancer: Southwest Oncology Group Study S0342  

PubMed Central

Purpose Randomized clinical trials failed to show a survival benefit for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors plus concurrent chemotherapy in patients with metastatic non–small-cell lung cancer (NSCLC), with preclinical data suggesting potential negative interactions. In contrast, pilot trials of the EGFR-targeted antibody, cetuximab, plus chemotherapy suggested enhanced antitumor activity. This randomized phase II trial was designed to select a cetuximab plus chemotherapy regimen for phase III evaluation. Patients and Methods Treatment-naive patients with advanced-stage NSCLC were randomly assigned to receive paclitaxel (225 mg/m2) and carboplatin (area under the curve, 6) every 3 weeks plus concurrent cetuximab (400 mg/m2 loading dose followed by 250 mg/m2 weekly) for four cycles followed by maintenance cetuximab or sequential paclitaxel-carboplatin for four cycles followed by cetuximab. Results Of 242 patients enrolled, 224 were eligible and assessable for response (106 and 118 patients in the concurrent and sequential arms, respectively). With a median follow-up time of 32 months, the median overall survival was 10.9 months (95% CI, 9.2 to 13.0 months) for patients receiving concurrent therapy and 10.7 months (95% CI, 8.5 to 12.8 months) for patients receiving sequential therapy (P = .57); 1-year survival rates were 45% (95% CI, 36% to 54%) and 44% (95% CI, 35% to 53%), respectively. Response rates and progression-free survival times were similar in both arms, as was grade 3 rash, whereas sensory neuropathy was higher in the concurrent arm (15% v 5% in the sequential arm; P = .036). Conclusion Although both regimens met the efficacy criterion for continued evaluation, the concurrent regimen of paclitaxel/carboplatin plus cetuximab was chosen.

Herbst, Roy S.; Kelly, Karen; Chansky, Kari; Mack, Philip C.; Franklin, Wilbur A.; Hirsch, Fred R.; Atkins, James N.; Dakhil, Shaker R.; Albain, Kathy S.; Kim, Edward S.; Redman, Mary; Crowley, John J.; Gandara, David R.

2010-01-01

60

Concurrency Control in Hierarchical Multidatabase Systems  

Microsoft Academic Search

Over the past decade, significant research has been done towards developing transaction management al- gorithms for multidatabase systems. Most of this work as- sumes a monolithic architecture of the multidatabase system with a single software module that follows a single trans- action management algorithm to ensure the consistency of data stored in the local databases. This monolithic architec- ture is

Sharad Mehrotra; Henry F. Korth; Abraham Silberschatz

1997-01-01

61

Concurrent Certifications by Intervals of Timestamps in Distributed Database Systems  

Microsoft Academic Search

This paper introduces, as an optimistic concurrency control method, a new certification method by means of intervals of timestamps, usable in a distributed database system. The main advantage of this method is that it allows a chronological commit order which differs from the serialization one (thus avoiding rejections or delays of transactions which occur in usual certification methods or in

Claude Boksenbaum; Michèle Cart; Jean Ferrié; Jean-françois Pons

1987-01-01

62

ACTORS: A model of concurrent computation in distributed systems  

Microsoft Academic Search

The transition from sequential to parallel computation is an area of critical concern in today's computer technology, particularly in architecture, programming languages, systems, and artificial intelligence. This book addresses issues in concurrency, and by producing both a syntactic definition and a denotational model of Hewitt's actor paradigm - a model of computation specifically aimed at constructing and analyzing distributed large-scale

G. Agha

1986-01-01

63

Radiation Therapy in the Management of Head-and-Neck Cancer of Unknown Primary Origin: How Does the Addition of Concurrent Chemotherapy Affect the Therapeutic Ratio?  

SciTech Connect

Purpose: To determine how the addition of cisplatin-based concurrent chemotherapy to radiation therapy influences outcomes among a cohort of patients treated for head-and-neck cancer of unknown primary origin. Methods and Materials: The medical records of 60 consecutive patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Thirty-two patients (53%) were treated by concurrent chemoradiation, and 28 patients (47%) were treated by radiation therapy alone. Forty-five patients (75%) received radiation therapy after surgical resection, and 15 patients (25%) received primary radiation therapy. Thirty-five patients (58%) were treated by intensity-modulated radiotherapy. Results: The 2-year estimates of overall survival, local-regional control, and progression-free survival were 89%, 89%, and 79%, respectively, among patients treated by chemoradiation, compared to 90%, 92%, and 83%, respectively, among patients treated by radiation therapy alone (p > 0.05, for all). Exploratory analysis failed to identify any subset of patients who benefited from the addition of concurrent chemotherapy to radiation therapy. The use of concurrent chemotherapy was associated with a significantly increased incidence of Grade 3+ acute and late toxicity (p < 0.001, for both). Conclusions: Concurrent chemoradiation is associated with significant toxicity without a clear advantage to overall survival, local-regional control, and progression-free survival in the treatment of head-and-neck cancer of unknown primary origin. Although selection bias cannot be ignored, prospective data are needed to further address this question.

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.edu [Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Farwell, D. Gregory [Department of Otolaryngology-Head and Neck Surgery, University of California Davis School of Medicine, Sacramento, CA (United States); Lau, Derick H. [Department of Medical Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Li Baoqing [Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA (United States); Luu, Quang; Donald, Paul J. [Department of Otolaryngology-Head and Neck Surgery, University of California Davis School of Medicine, Sacramento, CA (United States)

2011-10-01

64

Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).  

PubMed

The best strategy for incorporating imatinib in front-line treatment of Ph+ acute lymphoblastic leukemia (ALL) has not been established. We enrolled 92 patients with newly diagnosed Ph+ ALL in a prospective, multicenter study to investigate sequentially 2 treatment schedules with imatinib administered concurrent to or alternating with a uniform induction and consolidation regimen. Coadministration of imatinib and induction cycle 2 (INDII) resulted in a complete remission (CR) rate of 95% and polymerase chain reaction (PCR) negativity for BCR-ABL in 52% of patients, compared with 19% in patients in the alternating treatment cohort (P = .01). Remarkably, patients with and without a CR after induction cycle 1 (INDI) had similar hematologic and molecular responses after concurrent imatinib and INDII. In the concurrent cohort, grades III and IV cytopenias and transient hepatotoxicity necessitated interruption of induction in 87% and 53% of patients, respectively; however, duration of induction was not prolonged when compared with patients receiving chemotherapy alone. No imatinib-related severe hematologic or nonhematologic toxicities were noted with the alternating schedule. In each cohort, 77% of patients underwent allogeneic stem cell transplantation (SCT) in first CR (CR1). Both schedules of imatinib have acceptable toxicity and facilitate SCT in CR1 in the majority of patients, but concurrent administration of imatinib and chemotherapy has greater antileukemic efficacy. PMID:16638934

Wassmann, Barbara; Pfeifer, Heike; Goekbuget, Nicola; Beelen, Dietrich W; Beck, Joachim; Stelljes, Matthias; Bornhäuser, Martin; Reichle, Albrecht; Perz, Jolanta; Haas, Rainer; Ganser, Arnold; Schmid, Mathias; Kanz, Lothar; Lenz, Georg; Kaufmann, Martin; Binckebanck, Anja; Brück, Patrick; Reutzel, Regina; Gschaidmeier, Harald; Schwartz, Stefan; Hoelzer, Dieter; Ottmann, Oliver G

2006-09-01

65

Radiation and concurrent chemotherapy for the treatment of Lewis lung tumor and B16 melanoma tumor in C57/BL mice  

SciTech Connect

C57/BL mice bearing either Lewis lung tumor or B16 melanoma tumor were treated with radiation and concurrent chemotherapy. The treatment results were determined in vivo by tumor regrowth delay assay. When continuous infusion of either Cyclophosphamide (CYCLO) or 5-Fluorouracil (5-FU) or Adriamycin (ADRIA) or Mitomycin-C (MITO-C) was used in combination with continuous radiation at 1 cGy/min, no increase in tumor regrowth delay was observed over that of radiation alone. When multiple drug chemotherapy, FAM (5-FU, ADRIA, MITO-C) was administered in combination with radiation at 80 cGy/min, no increase in tumor regrowth delay was observed over that of radiation alone. In these two murine tumor models, when clinically relevant concentrations of commonly used chemotherapy agents were combined with radiation, no therapeutic advantage was observed.

Pedersen, J.E.; Barron, G.

1984-08-01

66

Three-dimensional conformal radiotherapy with concurrent chemotherapy for postoperative recurrence of esophageal squamous cell carcinoma: clinical efficacy and failure pattern  

PubMed Central

Background To assess the therapeutic outcome and failure pattern of three-dimensional conformal radiotherapy (3D-CRT)-based concurrent chemoradiotherapy (CCRT) for recurrence of esophageal squamous cell carcinoma (SCC) after radical surgery. Methods Treatment outcome and failure pattern were retrospectively evaluated in 83 patients with localized cervical and thoracic recurrences after radical surgery for thoracic esophageal SCC. All patients were treated with 3DCRT-based CCRT (median radiation dose 60 Gy), in which 39 received concurrent cisplatin plus 5-fluorouracil (PF), and 44 received concurrent docetaxel plus cisplatin (TP). Treatment response was evaluated at 1–3 months after CCRT. Results With a median follow-up of 34 months (range, 2–116 months), the 3-year overall survival (OS) of all the patients was 51.8% and the median OS time was 43.0 months. The overall tumor response rate was 75.9% (63/83), with a complete remission (CR) rate of 44.6% (37/83). In univariate analysis, tumor response after CCRT (p?=?0.000), recurrence site (p?=?0.028) and concurrent chemotherapy (p?=?0.090) showed a trend favoring better OS. Multivariate analysis revealed that tumor response after CCRT (p?=?0.000) and concurrent chemotherapy (p?=?0.010) were independent predictors of OS. Forty-seven patients had progressive diseases after CCRT, 27 had local failure (27/47, 57.4%), 18 had distant metastasis (18/47, 38.3%) and 2 had both local and distant failures (2/47, 4.3%). Conclusions 3DCRT-based CCRT is effective in postoperatively recurrent esophageal SCC. Patients that obtained complete remission after CCRT appeared to achieve long-term OS and might benefit from concurrent TP regimen. Local and distant failures remained high and prospective studies are needed to validate these factors.

2013-01-01

67

The evolution of the PVM concurrent computing system  

SciTech Connect

Concurrent and distributed computing, using portable software systems or environments on general purpose networked computing platforms, has recently gained widespread attention. Many such systems have been developed, and several are in production use. This paper describes the evolution of the PVM system, a software infrastructure for concurrent computing in networked environments. PVM has evolved over the past years; it is currently in use at several hundred institutions worldwide for applications ranging from scientific supercomputing to high performance computations in medicine, discrete mathematics, and databases, and for learning parallel programming. We describe the historical evolution of the PVM system, outline the programming model and supported features, present results gained from its use, list representative applications from a variety of disciplines that PVM has been used for, and comment on future trends and ongoing research projects.

Giest, G.A. [Oak Ridge National Lab., TN (United States); Sunderam, V.S. [Emory Univ., Atlanta, GA (United States). Dept. of Mathematics and Computer Science

1993-07-01

68

Hybrid Concurrent Constraint Simulation Models of Several Systems  

NASA Technical Reports Server (NTRS)

This distribution contains several simulation models created for the hybrid simulation language, Hybrid Concurrent Constraint (HCC). An HCC model contains the information specified in the widely-accepted academic definition of a hybrid system: this includes expressions for the modes of the systems to be simulated and the differential equations that apply in each mode. These expressions are written in the HCC syntax. The models included here were created by either applying basic physical laws or implementing equations listed in previously published papers.

Sweet, Adam

2003-01-01

69

Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial  

PubMed Central

Background Imatinib, given concurrently or alternating with chemotherapy, has improved the response and survival of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) but relapses are still frequent. The aim of this study was to evaluate the feasibility and results of giving imatinib concurrently with intensive chemotherapy, stem cell transplantation and post-transplant imatinib maintenance therapy in patients with newly diagnosed Ph+ ALL. Design and Methods This was a phase II study of patients with newly diagnosed Ph+ ALL given standard chemotherapy, together with imatinib (400 mg/day) until stem cell transplantation, followed by imatinib maintenance therapy for all patients regardless of the molecular status of the disease. Results Of the 30 patients included, 27 (90%) achieved complete remission, one was resistant to treatment and two died during induction therapy. The percentages of major and complete molecular responses were 86% and 21% after induction, and 81% and 65% after consolidation, respectively. Similar results were observed assessing minimal residual disease by flow cytometry. Of the 27 patients who achieved complete remission, 21 underwent stem cell transplantation (16 allogeneic, 5 autologous). Imatinib (400 mg/day) could be administered after transplantation for a median of 3.9 months in 12 patients, although it was interrupted in 10 patients (in 2 cases because of side effects of the drug). Nine patients relapsed, four before and five after stem cell transplantation and eight patients died of transplant-related causes. With a median follow-up of 4.1 years, the probabilities (95% CI) of disease-free and overall survival were 30% (15% to 45%) and 30% (16% to 45%), respectively. Conclusions These results confirm that imatinib is an effective first-line treatment for adult Ph+ ALL when given concurrently with chemotherapy, making stem cell transplantation feasible in a high proportion of patients. However, post-transplantation imatinib administration was limited, mainly because of transplantation-derived complications rather than drug-specific toxicity.

Ribera, Josep-Maria; Oriol, Albert; Gonzalez, Marcos; Vidriales, Belen; Brunet, Salut; Esteve, Jordi; del Potro, Eloy; Rivas, Concepcion; Moreno, Maria-Jose; Tormo, Mar; Martin-Reina, Victoria; Sarra, Josep; Parody, Ricardo; de Oteyza, Jaime Perez; Bureo, Encarna; Bernal, Maria-Teresa

2010-01-01

70

A concurrent distributed system for aircraft tactical decision generation  

NASA Technical Reports Server (NTRS)

A research program investigating the use of AI techniques to aid in the development of a tactical decision generator (TDG) for within visual range (WVR) air combat engagements is discussed. The application of AI programming and problem-solving methods in the development and implementation of a concurrent version of the computerized logic for air-to-air warfare simulations (CLAWS) program, a second-generation TDG, is presented. Concurrent computing environments and programming approaches are discussed, and the design and performance of prototype concurrent TDG system (Cube CLAWS) are presented. It is concluded that the Cube CLAWS has provided a useful testbed to evaluate the development of a distributed blackboard system. The project has shown that the complexity of developing specialized software on a distributed, message-passing architecture such as the Hypercube is not overwhelming, and that reasonable speedups and processor efficiency can be achieved by a distributed blackboard system. The project has also highlighted some of the costs of using a distributed approach to designing a blackboard system.

Mcmanus, John W.

1990-01-01

71

Primary systemic chemotherapy of breast cancer: indication and predictive factors  

Microsoft Academic Search

Primary systemic chemotherapy has become a standard of care for operable breast cancer patients who are candidates for adjuvant\\u000a chemotherapy. Induction of pathological complete response (pCR) is one of the main goals of primary systemic chemotherapy\\u000a because patients with pCR have shown a better prognosis. The definition of pCR has varied across clinical trials. It would\\u000a be ideal for all

Hiromitsu Jinno; Michio Sakata; Tetsu Hayashida; Maiko Takahashi; Tomomi Sato; Hirohito Seki; Yuko Kitagawa

2011-01-01

72

Randomized Clinical Trial of Weekly vs. Triweekly Cisplatin-Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Locally Advanced Cervical Cancer  

SciTech Connect

Purpose: To compare compliance, toxicity, and outcome of weekly and triweekly cisplatin administration concurrent with radiotherapy in locally advanced cervical cancer. Methods and Materials: In this open-label, randomized trial, 104 patients with histologically proven Stage IIB-IVA cervical cancer were randomly assigned by a computer-generated procedure to weekly (weekly cisplatin 40 mg/m{sup 2}, six cycles) and triweekly (cisplatin 75 mg/m{sup 2} every 3 weeks, three cycles) chemotherapy arms during concurrent radiotherapy. The difference of compliance and the toxicity profiles between the two arms were investigated, and the overall survival rate was analyzed after 5 years. Results: All patients tolerated both treatments very well, with a high completion rate of scheduled chemotherapy cycles. There was no statistically significant difference in compliance between the two arms (86.3% in the weekly arm, 92.5% in the triweekly arm, p > 0.05). Grade 3-4 neutropenia was more frequent in the weekly arm (39.2%) than in the triweekly arm (22.6%) (p = 0.03). The overall 5-year survival rate was significantly higher in the triweekly arm (88.7%) than in the weekly arm (66.5%) (hazard ratio 0.375; 95% confidence interval 0.154-0.914; p = 0.03). Conclusions: Triweekly cisplatin 75-mg/m{sup 2} chemotherapy concurrent with radiotherapy is more effective and feasible than the conventional weekly cisplatin 40-mg/m{sup 2} regimen and may be a strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer.

Ryu, Sang-Young, E-mail: ryu@kcch.re.kr [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Won-Moo; Kim, Kidong [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Park, Sang-Il [Department of Gynecologic Oncology, Dongnam Institute of Radiological and Medical Sciences, Busan (Korea, Republic of); Kim, Beob-Jong; Kim, Moon-Hong; Choi, Seok-Cheol [Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Cho, Chul-Koo [Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Nam, Byung-Ho [Cancer Biostatistics Branch, Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Lee, Eui-Don [Department of Gynecologic Oncology, Dongnam Institute of Radiological and Medical Sciences, Busan (Korea, Republic of)

2011-11-15

73

Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control  

SciTech Connect

Purpose: The impact of concurrent chemotherapy on the local control in patients with T2N0 laryngeal cancer who receive radiation therapy (RT) was evaluated. Methods and Materials: Sixty-three patients with T2N0 laryngeal cancer who were treated by definitive RT were analyzed. The primary site of the cancer was the glottis in 50 patients, the supraglottis in 9 patients, and the subglottis in 4 patients. Thirty-six patients were treated by RT alone and the remaining 27 patients received concurrent chemoradiotherapy (CRT). Results: Complete response (CR) was obtained in 92% of the patients who received RT alone and 100% of the patients who received CRT. Voice preservation in the group who received CRT (89%) was significantly higher than that in the group treated by RT alone (61%). The 5-year disease-free survival rates in those who received concurrent CRT was significantly superior to that in the patients who received RT alone, although no significant difference was seen in the cause-specific survival rate between the 2 groups. The multivariate analysis revealed that the treatment method (RT alone vs. CRT) was the most significant risk factor that predicted recurrence after RT. Conclusion: Concurrent CRT had a positive impact on the local control of T2N0 laryngeal cancer.

Akimoto, Tetsuo [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan)]. E-mail: takimoto@showa.gunma-u.ac.jp; Nonaka, Tetsuo [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Kitamoto, Yoshizumi [Department of Radiology, Gunma Prefectural Gunma Cancer Center, Gunma (Japan); Ishikawa, Hitoshi [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Ninomiya, Hiroshi [Department of Otolaryngology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Chikamatsu, Kazuaki [Department of Otolaryngology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Furuya, Nobuhiko [Department of Otolaryngology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan); Hayakawa, Kazushige [Department of Radiology, Kitasato University, Kitasato (Japan); Mitsuhashi, Norio [Department of Radiology, Tokyo Women's Medical University, Tokyo (Japan); Nakano, Takashi [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma (Japan)

2006-03-15

74

Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study  

PubMed Central

This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study.

Chen, Ming; Bao, Yong; Ma, Hong-Lian; Wang, Jin; Wang, Yan; Peng, Fang; Zhou, Qi-Chao; Xie, Cong-Hua

2013-01-01

75

Involved-field radiotherapy versus elective nodal irradiation in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer: a prospective randomized study.  

PubMed

This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study. PMID:23762840

Chen, Ming; Bao, Yong; Ma, Hong-Lian; Hu, Xiao; Wang, Jin; Wang, Yan; Peng, Fang; Zhou, Qi-Chao; Xie, Cong-Hua

2013-01-01

76

Induction chemotherapy with docetaxel, Cisplatin and Fluorouracil followed by surgery and concurrent chemoradiotherapy improves outcome of recurrent advanced head and neck squamous cell carcinoma.  

PubMed

Background: Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. Patients and Methods: We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with cisplatin and 5'-fluorouracil (TPF) group and the remaining twenty-nine patients are in the cisplatin and 5'-fluorouracil (PF) group. Results: The overall response rate was better in the TPF group (p=0.005) than the PF group. Patients who received induction chemotherapy, TPF, followed by surgery and concurrent chemoradiotherapy (CRT) had better overall survival (OS) (p=0.012) and progression-free survival (PFS) (p=0.038), while patients with prior intra-arterial-infusion-chemotherapy had an adverse impact on OS (p=0.039). Conclusion: We showed that induction chemotherapy with TPF, followed by surgery and consolidation CRT, is the ideal choice for recurrent advanced HNSCC with improving response rates and survival. However, prior intra-arterial-infusion-chemotherapy showed an adverse impact. PMID:24982400

Yang, Wen-Chi; Chen, Chung-Ho; Tang, Jen-Yang; Wu, Chih-Fung; Liu, Yi-Chang; Sun, Youping; Lin, Sheng-Fung

2014-07-01

77

Transurethral resection, neoadjuvant chemotherapy and accelerated hyperfractionated radiotherapy (concomitant boost), with or without concurrent cisplatin, for patients with invasive bladder cancer - clinical outcome  

PubMed Central

Aim of the study To evaluate the toxicity, clinical effectiveness and survival rate of transurethral resection, neoadjuvant chemotherapy and accelerated hyperfractionated radiotherapy (concomitant boost), with or without concurrent cisplatin in patients with muscle invasive bladder cancer. Material and methods Between March 2004 and December 2009, 35 patients with histologically proven invasive carcinoma of the bladder (T2-4a, N0-1, M0), who were fit for combined radiochemotherapy and refused radical surgery or were medically or surgically inoperable, were selected for the bladder-sparing protocol. Results In this study, twenty-five patients (25/35; 72%) received two cycles of neoadjuvant chemotherapy, and ten of them (10/35; 28%) only one, because of treatment-related toxicity. In twenty-one patients (21/35; 60%) chemotherapy consisting of gemcitabine with cisplatin and in fourteen patients (14/35; 40%) gemcitabine with carboplatin were applied. Only 13 patients (13/35; 37%) received combined irradiation with cisplatin. All patients completed their planned course of radiation therapy. Complete response (CR) occurred in 26/35 (74%) patients, partial response (PR) in 2/35(6%), and stable disease (SD) in 7/35 (20%). The overall actuarial survival rates at 3 and 5 years were 75% and 66%, respectively. Disease-specific actuarial survival rates at 3 and 5 years were 81% and 71%, respectively. Conclusions Conservative treatment of patients with muscle-invasive bladder cancer by transurethral resection, neoadjuvant chemotherapy, and accelerated hyperfractionated radiotherapy with concomitant boost, with or without concurrent cisplatin, provides a high probability of local and distal response with acceptable toxicity in properly selected patients.

Jakubowicz, Jerzy; Skora, Tomasz; Pudelek, Katarzyna

2013-01-01

78

Manufacturing Advisory Service System for Concurrent and Collaborative Design of MEMS Devices  

Microsoft Academic Search

This chapter first presents a concurrent collaborative design strategy for Micro-Electro-Mechanical Systems (MEMS). Then,\\u000a it presents the development of a knowledge intensive approach and system to select suitable manufacturing processes and materials\\u000a for MEMS devices a concurrent collaborative design environment. Fundamental issues on concurrent collaborative design for\\u000a manufacturability of MEMS and MEMS manufacturing process and material selection such as concurrent

Xuan F Zha

79

Systemes de Transitions Etiquetes Causaux: Une Novvelle Approche pour la Description du Comportement Evenementiel de Systemes Concurrents (Causal Labeled Transition Systems: A New Approach for Describing the Behavior of Concurrent Systems).  

National Technical Information Service (NTIS)

Causal labeled transition systems are proposed. This consists of a model of concurrent systems which has the same degree of simplicity as conventional labeled transition systems but permits concurrency among events to be expressed by causal independency. ...

R. J. Coelhodacosta

1993-01-01

80

Multiprocessor system with multiple concurrent modes of execution  

DOEpatents

A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

Ahn, Daniel; Ceze, Luis H; Chen, Dong; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

2013-12-31

81

Concurrent design of an RTP chamber and advanced control system  

SciTech Connect

A concurrent-engineering approach is applied to the development of an axisymmetric rapid-thermal-processing (RTP) reactor and its associated temperature controller. Using a detailed finite-element thermal model as a surrogate for actual hardware, the authors have developed and tested a multi-input multi-output (MIMO) controller. Closed-loop simulations are performed by linking the control algorithm with the finite-element code. Simulations show that good temperature uniformity is maintained on the wafer during both steady and transient conditions. A numerical study shows the effect of ramp rate, feedback gain, sensor placement, and wafer-emissivity patterns on system performance.

Spence, P. [Sandia National Labs., Livermore, CA (United States); Schaper, C. [Microelectronics Control and Sensing, Inc., Mountain View, CA (United States); Kermani, A. [CVC Products, Inc., Fremont, CA (United States)

1995-12-31

82

Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer  

SciTech Connect

Purpose: Pretreatment anemia is an adverse prognostic variable in squamous cell head-and-neck cancer (HNC) patients treated with radiotherapy (RT) alone. Tumor hypoxia is an adverse parameter for treatment with RT alone or with RT and concurrent chemotherapy (CCT). Tumor hypoxia is more prevalent in patients who present with pretreatment hemoglobin (Hgb) concentrations less than 13 g/dL. RT/CCT improves survival over RT alone in advanced HNC, and its use is becoming more widespread. This study was performed to evaluate whether pretreatment Hgb less than 13 g/dL was correlated with treatment outcome in patients with advanced HNC treated with a uniform regimen of RT/CCT. Methods and materials: The study population consisted of patients with AJCC Stage III or IV, M0 HNC who were treated with 70 to 72.5 Gy accelerated hyperfractionated RT (1.25 Gy b.i.d.) and CCT consisting of 2 cycles of CDDP (12-20 mg/m{sup 2}/d x 5 days) and continuous infusion 5-FU (600 mg/m{sup 2}/d x 5 days) during Week 1 and Week 6. A planned break in RT occurred during Week 4. These patients were enrolled on the experimental arm of a prospective randomized trial that compared this regimen to hyperfractionated irradiation alone from 1990 to 1996. RT/CCT was delivered as standard therapy from 1996 to 2000. The primary endpoint was failure-free survival (FFS). Secondary endpoints included local-regional control and overall survival. Results: One hundred and fifty-nine patients were treated from 1990 to 2000. The median (25-75%) pretreatment Hgb was 13.6 (12.2-13.5) g/dL. Hgb was 13 g/dL or higher in 105 patients and less than 13 g/dL in 54 patients. Primary tumor sites included oropharynx (43%), hypopharynx/larynx (36%), oral cavity (9%), and nasopharynx (6%). Seventy-eight percent of the patients with Hgb 13 g/dL or higher and 92% of the patients with Hgb less than 13 g/dL had a primary tumor stage of T3 or T4 (p = 0.01). Node-positive disease was present in 74 of 105 (70%) of patients with Hgb 13 g/dL or higher patients and in 36/54 (67%) of patients with Hgb less than 13 g/dL patients. Median follow-up of surviving patients was 42 months (range, 4-128 months). Five-year FFS was 75% for patients with Hgb 13 g/dL or higher vs. 50% for patients with Hgb less than 13 g/dL had a (p < 0.01). A total of 49 failures occurred in both patient cohorts. The median (25-75%) decrease in Hgb during RT/CCT was 2.2 (1.3-3.1) g/dL, both in patients who failed and in those who remained disease-free. Conclusion: Pretreatment Hgb less than 13 g/dL is correlated with adverse outcomes in advanced HNC patients treated with RT/CCT. Whether anemia actually causes poor outcomes remains unknown. The therapeutic effect of anemia correction is being evaluated in prospective trials.

Prosnitz, Robert G. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)]. E-mail: robert.prosnitz@duke.edu; Yao, Bin M.S. [Amgen, Inc. Thousand Oaks, CA (United States); Farrell, Catherine L. [Amgen, Inc. Thousand Oaks, CA (United States); Clough, Robert [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Brizel, David M. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)

2005-03-15

83

SystemCSP : a graphical language for designing concurrent component-based embedded control systems  

Microsoft Academic Search

The main contribution of this thesis is the introduction of SystemCSP, a novel graphical design language for specification of interactions in concurrent component based embedded control systems. SystemCSP was developed in the scope of the embedded control systems application area. However, SystemCSP is intended to be used in any kind of software\\/hardware development dealing with interaction of concurrent components.

Bojan Orlic

2007-01-01

84

Partial Orderings of Event Sets and Their Application to Prototyping Concurrent, Timed Systems  

Microsoft Academic Search

Rapide is a concurrent, object-oriented language specifically designed for prototypinglarge concurrent systems. One of the principle design goals has been to adopt a computationmodel in which the synchronization, concurrency, dataflow, and timing aspects ofa prototype are explicitly represented and easily accessible both to the prototype itselfand to the prototyper. This paper describes the partially ordered event set (poset) computationmodel, and

David C. Luckham; James Vera; Doug Bryan

1992-01-01

85

A modified Phase I trial of radiation dose escalation in 3D conformal radiation therapy with concurrent vinorelbine and carboplatin chemotherapy for non-small-cell lung cancer  

PubMed Central

The Radiation Therapy Oncology Group reported a maximum tolerated dose of 74 Gy for patients with non-small cell lung cancer (NSCLC); however, it was unclear whether this dose could be safely administered to Asian patients due to differences in their physique compared to Western patients. We therefore conducted a modified Phase I trial to determine whether 70 Gy could be safely delivered to Chinese patients with NSCLC undergoing 3D-conformal radiation therapy (3D-CRT) with concurrent chemotherapy. Previously untreated NSCLC patients received 3D-CRT (2 Gy/day, 5 fractions per week). Three dose levels were examined: 62, 66 and 70 Gy. Two cycles of concurrent chemotherapy (vinorelbine and carboplatin) were started on the first day of radiation therapy. Dose-limiting toxicity (DLT) was defined as severe or life-threatening side effects that altered the continued implementation of chemoradiotherapy. Among the 19 patients recruited in this study, most of the haematologic and non-haematologic toxicities were mild to moderate and clinically manageable. Only one patient, in the 70 Gy cohort, experienced a DLT of Grade 3 radiation-induced pneumonia. The overall response rate was 77.8% (14/18). The median progression-free survival (PFS) was 12 months, and the 1-year PFS was 37.6%. Our results support both the feasibility of incorporating 3D-CRT with concurrent vinorelbine and carboplatin and a dose escalation to 70 Gy for Chinese patients with NSCLC, based on the acceptable toxicity and encouraging overall response and survival rates. A further evaluation of this regimen in a prospective Phase II trial is ongoing.

Lin, Qiang; Liu, Yue'e; Wang, Na; Huang, Yuehua; Ge, Xiaohui; Ren, Xiaocang; Chen, Xueji; Hu, Jing; Guo, Zhijun; Zhao, Yannan; Asaumi, Junichi

2013-01-01

86

Radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for N2-3 nasopharyngeal cancer: a multicenter trial of the Forum for Nuclear Cooperation in Asia  

PubMed Central

The purpose of this study was to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for the treatment of N2–3 nasopharyngeal cancer (NPC) in Asian countries, especially regions of South and Southeast Asian countries where NPC is endemic. Between 2005 and 2009, 121 patients with NPC (T1–4 N2–3 M0) were registered from Vietnam, Malaysia, Indonesia, Thailand, The Philippines, China and Bangladesh. Patients were treated with 2D radiotherapy concurrently with weekly cisplatin (30 mg/m 2), followed by adjuvant chemotherapy, consisting of cisplatin (80 mg/m2 on Day 1) and fluorouracil (800 mg/m2 on Days 1–5) for 3 cycles. Of the 121 patients, 56 patients (46%) required interruption of RT. The reasons for interruption of RT were acute non-hematological toxicities such as mucositis, pain and dermatitis in 35 patients, hematological toxicities in 11 patients, machine break-down in 3 patients, poor general condition in 2 patients, and others in 8 patients. Of the patients, 93% completed at least 4 cycles of weekly cisplatin during radiotherapy, and 82% completed at least 2 cycles of adjuvant chemotherapy. With a median follow-up time of 46 months for the surviving 77 patients, the 3-year locoregional control, distant metastasis-free survival and overall survival rates were 89%, 74% and 66%, respectively. No treatment-related deaths occurred. Grade 3–4 toxicities of mucositis, nausea/vomiting and leukopenia were observed in 34%, 4% and 4% of the patients, respectively. In conclusion, further improvement in survival and locoregional control is necessary, although our regimen showed acceptable toxicities.

Ohno, Tatsuya; Thinh, Dang Huy Quoc; Kato, Shingo; Devi, C.R. Beena; Tung, Ngo Thanh; Thephamongkhol, Kullathorn; Calaguas, Miriam Joy C.; Zhou, Juying; Chansilpa, Yaowalak; Supriana, Nana; Erawati, Dyah; Banu, Parvin Akhter; Koo, Cho Chul; Kobayashi, Kunihiko; Nakano, Takashi; Tsujii, Hirohiko

2013-01-01

87

Factors Associated With Severe Acute Esophagitis From Hyperfractionated Radiotherapy With Concurrent Chemotherapy for Limited-Stage Small-Cell Lung Cancer  

SciTech Connect

Purpose: To describe incidence and identify factors associated with development of severe acute esophagitis during hyperfractionated radiotherapy with concurrent chemotherapy (BID-CRT) in patients with limited-stage small-cell lung cancer (SCLC). Methods and Materials: Retrospective cohort analysis of patient-, tumor-, and treatment-related variables was performed to identify factors associated with Radiation Therapy Oncology Group (RTOG) Grade 3 acute esophagitis. Twice-daily chemoradiotherapy (BID-CRT) involved 45 Gy at 1.5 Gy per fraction, treated twice daily with concurrent platinum-based chemotherapy. Logistic regression analyses were used to identify factors associated with esophagitis. Results: Between June 1999 and June 2007, 48 patients underwent curative intent BID-CRT for SCLC and were included in the analysis. Median radiotherapy dose was 45 Gy (range, 42-51 Gy) delivered with a median 4 cycles of chemotherapy (range, 2-6). RTOG Grade 3 acute esophagitis developed in 11 patients. No patient developed Grade 4 or 5 esophagitis. Simple logistic regression analyses demonstrated a highly significant association between Grade 3 acute esophagitis and mean esophageal dose (p = 0.002) as well as relative volume dosimetric area under curve (RV-AUC; p = 0.004). Using multiple regression analysis, RV-AUC was identified as the only factor associated with Grade 3 esophagitis (p = 0.004). The most strongly associated dosimetric volume was the V15 (Grade 3 esophagitis rates of 15% vs. 64% for V15 <60% versus {>=}60%, respectively). Conclusions: RV-AUC is the factor most associated with development of Grade 3 acute esophagitis in limited stage SCLC patients receiving BID-CRT.

Watkins, John M. [Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina (United States); Wahlquist, Amy E. M.S. [Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina (United States); Shirai, Keisuke [Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina (United States); Garrett-Mayer, Elizabeth [Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina (United States); Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina (United States); Aguero, Eric G.; Fortney, John A. [Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina (United States); Sherman, Carol A. [Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina (United States); Sharma, Anand K. [Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina (United States)], E-mail: sharmaak@musc.edu

2009-07-15

88

Concurrent validity of vertical jump performance assessment systems.  

PubMed

The aim of this study was to examine the concurrent validity of 2 portable systems for vertical jump (VJ) assessment under field conditions. The VJ flight times assessed using an optical mat (Optojump) and an accelerometer-based (Myotest) system were compared with that of a force platform. The flight times recorded during a countermovement jump (CMJ) were collected from 20 rugby players (n = 86 jumps) concurrently using the 3 tracking systems. Significant bias between the Force platform and either the Optojump (bias = 0.006 ± 0.007; 95% confidence interval [CI] 0.004-0.007 seconds) and Myotest (bias = -0.031 ± 0.021; 95% CI 0.035 to -0.026s; p < 0.0001) occurred. A nearly perfect correlation was found between force platform and Optojump (r = 0.99; 95% CI 0.098-0.99; p < 0.0001). Force platform and Myotest (r = 0.89; 95% CI 0.084-0.93; p < 0.0001) flight times showed very large association. Difference between Optojump and Myotest systems was significant (-0.036 ± 0.021 seconds; 95% CI -0.041 to -0.032; p < 0.0001), which results in Myotest mean flight time being approximately 7.2% longer than the Optojump flight time. The association between Optojump and Myotest was nearly perfect (r = 0.91, 95% CI 0.86-0.94; p < 0.0001). This study showed that the Optojump and Myotest systems possess convergent validity and can be successfully used under field conditions to assess VJ while performing a CMJ. However, caution should be exercised when interpreting data obtained from different portable systems for field measurement. PMID:22648140

Castagna, Carlo; Ganzetti, Marco; Ditroilo, Massimiliano; Giovannelli, Marco; Rocchetti, Alessandro; Manzi, Vincenzo

2013-03-01

89

MACHINE PROTECTION SYSTEM FOR CONCURRENT OPERATION OF RHIC AND BLIP.  

SciTech Connect

The Brookhaven 200MeV linac is a multipurpose machine used to inject low intensity polarized protons for RHIC (Relativistic Heavy Ion Collider), as well as to inject high intensity protons to BLIP (Brookhaven Linac Isotope Producer), a medical isotope production facility. If high intensity protons were injected to RHIC by mistake, administrative radiation limits could be exceeded or sensitive electronics could be damaged. In the past, the changeover from polarized proton to high intensity proton operation has been a lengthy process, thereby never allowing the two programs to run simultaneously. To remedy this situation and allow concurrent operation of RHIC and BLIP, an active interlock system has been designed to monitor current levels in the AGS using two current transformers with fail safe circuitry and associated electronics to inhibit beam to RHIC if high intensity currents are detected.

WILINSKI, M.; BELLAVIA, S.; GLENN, J.W.; MAUSNER, L.F.; UNGER, K.L.

2005-05-16

90

Heuristic networks for concurrent pursuit-evasion systems  

Microsoft Academic Search

We consider briefly the linguistic geometry tools and their application to solving 2D optimization problem for autonomous robotic vehicles participating in the aerospace pursuit-evasion game. In this problem we allow the agents to move simultaneously if necessary. A comparison of the searches for aerial and concurrent cases shows that search reduction achieved in the concurrent case is even more dramatic

Boris Stilman

1995-01-01

91

Concurrent multi-lingual use in data processing systems  

SciTech Connect

This patent describes a method of providing a distributed, interactive data processing system with concurrent multi-lingual use by many users. The data processing system includes a message composition service. The method consists of establishing a message model data collection by storing message models. The message models are stored with a message identifier primary key that is common for all usage and a secondary key that is a national language index, establishing for each user who signs onto the system a national language index corresponding to the secondary key, requesting the message composition service to compose a message for use by an interactive program run on the system. The message is identified by the primary key for the specific message requested and the secondary key established for the user for which the message is intended, retrieving from the message model data collection message models using the primary and secondary keys in response to a request to compose a message, composing the message from the message models retrieved from the message model data collection, and storing the composed message so that it can be used by the interactive program to communicate the message to the user.

Crabtree, P.R.

1986-01-21

92

Integrated Information Systems for Electronic Chemotherapy Medication Administration  

PubMed Central

Introduction: Chemotherapy administration is a highly complex and distributed task in both the inpatient and outpatient infusion center settings. The American Society of Clinical Oncology and the Oncology Nursing Society (ASCO/ONS) have developed standards that specify procedures and documentation requirements for safe chemotherapy administration. Yet paper-based approaches to medication administration have several disadvantages and do not provide any decision support for patient safety checks. Electronic medication administration that includes bar coding technology may provide additional safety checks, enable consistent documentation structure, and have additional downstream benefits. Methods: We describe the specialized configuration of clinical informatics systems for electronic chemotherapy medication administration. The system integrates the patient registration system, the inpatient order entry system, the pharmacy information system, the nursing documentation system, and the electronic health record. Results: We describe the process of deploying this infrastructure in the adult and pediatric inpatient oncology, hematology, and bone marrow transplant wards at Vanderbilt University Medical Center. We have successfully adapted the system for the oncology-specific documentation requirements detailed in the ASCO/ONS guidelines for chemotherapy administration. However, several limitations remain with regard to recording the day of treatment and dose number. Conclusion: Overall, the configured systems facilitate compliance with the ASCO/ONS guidelines and improve the consistency of documentation and multidisciplinary team communication. Our success has prompted us to deploy this infrastructure in our outpatient chemotherapy infusion centers, a process that is currently underway and that will require a few unique considerations.

Levy, Mia A.; Giuse, Dario A.; Eck, Carol; Holder, Gwen; Lippard, Giles; Cartwright, Julia; Rudge, Nancy K.

2011-01-01

93

High-dose Extended-Field Irradiation and High-Dose-Rate Brachytherapy With Concurrent Chemotherapy for Cervical Cancer With Positive Para-Aortic Lymph Nodes  

SciTech Connect

Purpose: To determine the efficacy and toxicity of extended-field radiotherapy (RT) with concurrent platinum-based chemotherapy in patients with uterine cervical carcinoma and positive para-aortic nodes. Methods and Materials: We retrospectively reviewed the results for 33 women with Stage IB-IVB cervical cancer. Each patient had received 59.4 Gy, including a three-dimensional conformal boost to the para-aortic lymph nodes and 41.4-50.4 Gy of external beam radiotherapy to the pelvis. Each patient also underwent six or seven applications of high-dose-rate brachytherapy (median, 5 Gy to point A at each session). Results: The median follow-up period of surviving patients was 39 months. The most common acute toxicity was hematologic, observed in 23 women. Severe acute and late gastrointestinal toxicity was observed in 3 and 4 patients, respectively. More than three-quarters of patients showed a complete response, encompassing the primary mass, metastatic pelvic, and para-aortic lymph nodes. Of the 33 women, 15 had no evidence of disease, 6 had persistent disease, 4 developed in-field failures, and 6 developed distant failures. The 5-year overall and disease-free survival rate was 47% and 42%, respectively. Conclusion: Concurrent chemoradiotherapy with extended-field radiotherapy is feasible in women with uterine cervical carcinoma and positive para-aortic lymph nodes, with acceptable late morbidity and a high survival rate, although it was accompanied by substantial acute toxicity.

Kim, Young Seok; Kim, Jong Hoon; Ahn, Seung Do; Lee, Sang-wook; Shin, Seong Soo [Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Nam, Joo-Hyun; Kim, Young-Tak; Kim, Yong-Man; Kim, Jong-Hyeok [Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Choi, Eun Kyung [Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)], E-mail: ekchoi@amc.seoul.kr

2009-08-01

94

Real time groupware as a distributed system: concurrency control and its effect on the interface  

Microsoft Academic Search

This paper exposes the concurrency control problem in groupware when it is implemented as a distributed system. Traditional concurrency control methods cannot be applied directly to groupware because system interactions include people as well as computers. Methods, such as locking, serialization, and their degree of optimism, are shown to have quite different impacts on the interface and how operations are

Saul Greenberg; David Marwood

1994-01-01

95

A meta-analysis of randomized controlled trials comparing early and late concurrent thoracic radiotherapy with etoposide and cisplatin/carboplatin chemotherapy for limited-disease small-cell lung cancer  

PubMed Central

The aim of the present study was to determine the optimal time for concurrent thoracic radiotherapy (TRT) with etoposide and cisplatin/carboplatin (EP/EC) chemotherapy for the treatment of limited-disease small-cell lung cancer (LD SCLC). Randomized controlled trials comparing early and late concurrent TRT with EP/EC chemotherapy for the treatment of patients with LD SCLC were identified through searching databases such as MEDLINE, the Cochrane Central Register of Controlled Trials and Embase. Early thoracic radiotherapy (ERT) was defined as initiating irradiation within 30 days after chemotherapy initiation. A total of 3 eligible randomized controlled trials were identified. No significant differences in the objective response rate were detected between early and late concurrent TRT [risk ratio (RR)=1.01; 95% confidence interval (CI): 0.86–1.18; P=0.90]. Similar results were observed in the 1-, 2-, 3- and 5-year survival rates between early and late concurrent TRT (RR=1.06, 95% CI: 0.88–1.27, P=0.56; RR=1.15, 95% CI: 0.77–1.71, P=0.49; RR=0.90, 95% CI: 0.66–1.22, P=0.49; and RR=1.18, 95% CI: 0.64–2.16, P=0.60, respectively). The total incidence of grade 3–4 adverse events, including anemia, leukopenia, neutropenia, thrombocytopenia, nausea and vomiting, infection, esophageal toxicity, pulmonary toxicity, alopecia and hemorrhage with early concurrent TRT was significantly higher compared to that with late concurrent TRT (RR=1.21, 95% CI: 1.03–1.43, P=0.02). Thus, the results of our study indicated that the prognosis of LD SCLC treated with late concurrent TRT and EP/EC chemotherapy is similar to that with early concurrent TRT, although the incidence of grade 3–4 adverse events was lower in LD SCLC patients treated with late concurrent TRT combined with EP/EC chemotherapy.

LU, HONGYANG; FANG, LUO; WANG, XIAOJIA; CAI, JUFEN; MAO, WEIMIN

2014-01-01

96

Postoperative Radiation Therapy With or Without Concurrent Chemotherapy for Node-Positive Thoracic Esophageal Squamous Cell Carcinoma  

SciTech Connect

Purpose: To retrospectively compare the efficacy of radiation therapy (RT) and chemotherapy plus RT (CRT) for the postoperative treatment of node-positive thoracic esophageal squamous cell carcinoma (TESCC) and to determine the incidence and severity of toxic reactions. Methods and Materials: We retrospectively reviewed data from 304 patients who had undergone esophagectomy with 3-field lymph node dissection for TESCC and were determined by postoperative pathology to have lymph node metastasis without distant hematogenous metastasis. Of these patients, 164 underwent postoperative chemotherapy (cisplatin 80 mg/m{sup 2}, average days 1-3, plus paclitaxel 135 mg/m{sup 2}, day 1; 21-day cycle) plus RT (50 Gy), and 140 underwent postoperative RT alone. Results: The 5-year overall survival rates for the CRT and RT groups were 47.4% and 38.6%, respectively (P=.030). The distant metastasis rate, the mixed (regional lymph node and distant) metastasis rate, and the overall recurrence rate were significantly lower in the CRT group than in the RT group (P<.05). However, mild and severe early toxic reactions, including neutropenia, radiation esophagitis, and gastrointestinal reaction, were significantly more common in the CRT group than in the RT group (P<.05). No significant differences in incidence of late toxic reactions were found between the 2 groups. Conclusions: Our results show that in node-positive TESCC patients, postoperative CRT is significantly more effective than RT alone at increasing the overall survival and decreasing the rates of distant metastasis, mixed metastasis, and overall recurrence. Severe early toxic reactions were more common with CRT than with RT alone, but patients could tolerate CRT.

Chen, Junqiang; Pan, Jianji [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Liu, Jian, E-mail: liujianfj@yahoo.com.cn [Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fuzhou (China); Li, Jiancheng [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Zhu, Kunshou [Department of Surgery, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Surgery, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Zheng, Xiongwei [Department of Pathology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Pathology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Chen, Mingqiang [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Chen, Ming [School of Graduate, Fujian University of Traditional Chinese Medicine, Fuzhou (China)] [School of Graduate, Fujian University of Traditional Chinese Medicine, Fuzhou (China); Liao, Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2013-07-15

97

Deadlock avoidance in flexible manufacturing systems with concurrently competing process flows  

Microsoft Academic Search

The concurrent flow of multiple jobs through a FMS can lead to deadlock conditions due to competition for limited resources in the system. The authors develop a Petri net (PN) model of concurrent job flow and dynamic resource allocation in an FMS and define deadlock in terms of transition enabling in the PN model. The problem of deadlock avoidance is

Z. A. Banaszak; B. H. Krogh

1990-01-01

98

Dose Escalation of Total Marrow Irradiation With Concurrent Chemotherapy in Patients With Advanced Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation  

SciTech Connect

Purpose: We have demonstrated that toxicities are acceptable with total marrow irradiation (TMI) at 16 Gy without chemotherapy or TMI at 12 Gy and the reduced intensity regimen of fludarabine/melphalan in patients undergoing hematopoietic cell transplantation (HCT). This article reports results of a study of TMI combined with higher intensity chemotherapy regimens in 2 phase I trials in patients with advanced acute myelogenous leukemia or acute lymphoblastic leukemia (AML/ALL) who would do poorly on standard intent-to-cure HCT regimens. Methods and Materials: Trial 1 consisted of TMI on Days -10 to -6, etoposide (VP16) on Day -5 (60 mg/kg), and cyclophosphamide (CY) on Day -3 (100 mg/kg). TMI dose was 12 (n=3 patients), 13.5 (n=3 patients), and 15 (n=6 patients) Gy at 1.5 Gy twice daily. Trial 2 consisted of busulfan (BU) on Days -12 to -8 (800 {mu}M min), TMI on Days -8 to -4, and VP16 on Day -3 (30 mg/kg). TMI dose was 12 (n=18) and 13.5 (n=2) Gy at 1.5 Gy twice daily. Results: Trial 1 had 12 patients with a median age of 33 years. Six patients had induction failures (IF), and 6 had first relapses (1RL), 9 with leukemia blast involvement of bone marrow ranging from 10%-98%, 5 with circulating blasts (24%-85%), and 2 with chloromas. No dose-limiting toxicities were observed. Eleven patients achieved complete remission at Day 30. With a median follow-up of 14.75 months, 5 patients remained in complete remission from 13.5-37.7 months. Trial 2 had 20 patients with a median age of 41 years. Thirteen patients had IF, and 5 had 1RL, 2 in second relapse, 19 with marrow blasts (3%-100%) and 13 with peripheral blasts (6%-63%). Grade 4 dose-limiting toxicities were seen at 13.5 Gy (stomatitis and hepatotoxicity). Stomatitis was the most frequent toxicity in both trials. Conclusions: TMI dose escalation to 15 Gy is possible when combined with CY/VP16 and is associated with acceptable toxicities and encouraging outcomes. TMI dose escalation is not possible with BU/VP16 due to dose-limiting toxicities. Future efforts will focus on whether further dose escalation with CY/VP16 is safe, with the goal of improving disease control in this high-risk population.

Wong, Jeffrey Y.C., E-mail: jwong@coh.org [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States); Forman, Stephen; Somlo, George [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)] [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States); Rosenthal, Joseph [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States) [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States); Department of Pediatrics, City of Hope National Medical Center, Duarte, California (United States); Liu An; Schultheiss, Timothy; Radany, Eric [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States)] [Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California (United States); Palmer, Joycelynne [Department of Biostatistics, City of Hope National Medical Center, Duarte, California (United States)] [Department of Biostatistics, City of Hope National Medical Center, Duarte, California (United States); Stein, Anthony [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)] [Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California (United States)

2013-01-01

99

PVM system: Supercomputer level concurrent computation on a network of IBM RS/6000 power stations.  

National Technical Information Service (NTIS)

The PVM (Parallel Virtual Machine) system enables supercomputer level concurrent computations to be performed on interconnected networks of heterogeneous computer systems. Specifically, a network of 13 IBM RS/6000 powerstations has been successfully used ...

V. S. Sunderam G. A. Geist

1991-01-01

100

Elective lymph node irradiation late course accelerated hyper-fractionated radiotherapy plus concurrent cisplatin-based chemotherapy for esophageal squamous cell carcinoma: a phase II study  

PubMed Central

Background In this phase II study, we evaluated the efficacy, toxicity, and patterns of failure of elective lymph node irradiation (ENI) late course accelerated hyper-fractionated radiotherapy (LCAHRT) concurrently with cisplatin-based chemotherapy (CHT) for esophageal squamous cell carcinoma (ESCC). Methods Patients with clinical stage II-IVa (T1-4N0-1M0 or M1a) ESCC were enrolled between 2004 and 2011. Radiation therapy (RT) comprised two courses: The first course of radiation covered the primary and metastatic regional tumors and high risk lymph nodal regions, given at 2 Gy per fraction for a dose of 40 Gy. In the second course, LCAHRT was delivered to the boost volume twice a day for an additional 19.6 Gy in 7 treatment days, using 1.4 Gy per fraction. Two cycles of CHT were given at the beginning of RT. Results The median age and Karnofsky performance status were 63 years and 80, respectively. The American Joint Committee on Cancer stage was II in 14 (20.6%) patients, III in 32 (47.1%), and IVa in 22 (32.3%). With a median follow-up of 18.5 months, the overall survival at 1-, 3-, 5-year were 75.5%, 46.5%, 22.7% for whole group patients, versus 78.6%, 49.4%, 39.9% for patients with stage II–III. The patterns of first failure from local recurrence, regional failure, and distant metastasis were seen in 20.6%, 17.6%, and 19.1%, respectively. The most frequent acute high-grade (? 3) toxicities were esophagitis and leucopenia, occurred in 26.4% and 32.4%. Conclusions ENI LCAHRT concurrently with CHT was appeared to be an effective regimen for ESCC patient with a favorable and tolerated profile. Further observation with longer time and randomized phase III trial is currently underway. Trial registration ChiCTR-TRC-09000568

2013-01-01

101

Bortezomib and Chemotherapy for Systemic Light-Chain Amyloidosis  

Cancer.gov

In this trial, patients with previously untreated systemic light-chain amyloidosis will be randomly assigned to receive melphalan and dexamethasone with or without bortezomib. Doctors will assess the overall hematologic response rates to these chemotherapy regimens, as well as organ responses.

102

HPV Genotypes Predict Survival Benefits From Concurrent Chemotherapy and Radiation Therapy in Advanced Squamous Cell Carcinoma of the Cervix  

SciTech Connect

Purpose: To study the prognostic value of human papillomavirus (HPV) genotypes in patients with advanced cervical cancer treated with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). Methods and Materials: Between August 1993 and May 2000, 327 patients with advanced squamous cell carcinoma of the cervix (International Federation of Gynecology and Obstetrics stage III/IVA or stage IIB with positive lymph nodes) were eligible for this study. HPV genotypes were determined using the Easychip Registered-Sign HPV genechip. Outcomes were analyzed using Kaplan-Meier survival analysis and the Cox proportional hazards model. Results: We detected 22 HPV genotypes in 323 (98.8%) patients. The leading 4 types were HPV16, 58, 18, and 33. The 5-year overall and disease-specific survival estimates for the entire cohort were 41.9% and 51.4%, respectively. CCRT improved the 5-year disease-specific survival by an absolute 9.8%, but this was not statistically significant (P=.089). There was a significant improvement in disease-specific survival in the CCRT group for HPV18-positive (60.9% vs 30.4%, P=.019) and HPV58-positive (69.3% vs 48.9%, P=.026) patients compared with the RT alone group. In contrast, the differences in survival with CCRT compared with RT alone in the HPV16-positive and HPV-33 positive subgroups were not statistically significant (P=.86 and P=.53, respectively). An improved disease-specific survival was observed for CCRT treated patients infected with both HPV16 and HPV18, but these differenced also were not statistically significant. Conclusions: The HPV genotype may be a useful predictive factor for the effect of CCRT in patients with advanced squamous cell carcinoma of the cervix. Verifying these results in prospective trials could have an impact on tailoring future treatment based on HPV genotype.

Wang, Chun-Chieh [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, School of Medicine, Taoyuan, Taiwan (China); Lai, Chyong-Huey [Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China)] [Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China); Huang, Yi-Ting [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China)] [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China); Chao, Angel; Chou, Hung-Hsueh [Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China)] [Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China); Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, School of Medicine, Taoyuan, Taiwan (China)

2012-11-15

103

Report on the feasibility of hypercube concurrent processing systems in computational fluid dynamics  

NASA Astrophysics Data System (ADS)

The feasibility of using hypercube-connected concurrent processor systems for problems in computational fluid dynamics is studied. Both explicit and implicit numerical methods are considered and several alternative implementations of these methods are evaluated on concurrent processor systems. A Lax-Wendroff explicit method was designed and implemented for the Navier-Stokes equations. The code runs on the Intel iPSC concurrent processor system. Tests of this code show that it is reasonably efficient. The Beam and Warming implicit factored method was designed and implemented for Berger's equation. Preliminary tests show that the efficiency of code is poor.

Bruno, J.

1986-03-01

104

The use of nanoparticulate delivery systems in metronomic chemotherapy.  

PubMed

Metronomic chemotherapy aiming at inhibiting tumor angiogenesis with conventional chemotherapeutics is a promising strategy for antiangiogenic cancer therapy. However, current metronomic chemotherapy mainly focuses on free small-molecule drugs, without any effort to achieve tumor-specific biodistribution, which may lead to long-term toxicity concerns. Metronomic chemotherapy using nanoparticulate drug delivery system (DDS) offers significant upside to reduce off-target side effects, decrease accumulated dose, and enhance the efficacy of tumor vessel targeting without compromising antitumor efficacy; but there has been a lack of thorough experimental data describing the targeted metronomic chemotherapy. Here, we develop a new nanoparticulate DDS, SP5.2 peptide conjugated, Flt-1 (VEGFR-1) targeted nanoparticles for docetaxel (SP5.2-DTX-NP), as a model for the investigation of targeted metronomic chemotherapy with respect to both antitumor efficacy and toxicity. The results demonstrate that metronomic SP5.2-DTX-NP exerts antitumor activity mainly through the antiangiogenic effect of docetaxel, which is specifically delivered into the tumor vascular endothelial cells through the nanoparticle internalization mediated by the interaction of SP5.2 and over-expressed Flt-1 receptors on tumor vessels. Moreover, the antitumor efficacy of targeted metronomic chemotherapy is better than that of the treatment with the DDS given in the maximum tolerated dose (MTD) regimen, which is shown in significantly prolonged mice survival and minimal drug-associated toxicity (bone marrow suppression, hematological toxicity, and mucosal injury of small intestine). The present research reveals and highlights the significance of targeted metronomic therapy with nanoparticulate DDS in antiangiogenic cancer therapy. PMID:23465835

Yu, De-Hong; Ban, Fu-Qiang; Zhao, Mei; Lu, Qin; Lovell, Jonathan F; Bai, Fan; Wang, Chao; Guan, Ying-Yun; Luan, Xin; Liu, Ya-Rong; Fang, Chao; Chen, Hong-Zhuan

2013-05-01

105

A specification-based approach to concurrent structure verification in multiprocessor systems  

NASA Technical Reports Server (NTRS)

A recently initiated research project concerned with the concurrent detection of software errors and errors due to physical failures in the hardware of multiprocessor systems is described in this paper. An approach to error detection is described, which is specification based and relies on the structural verification of program control flow and data structure integrity. The techniques discussed utilize the hardware redundancy inherent in parallel processing systems to provide verification of both program structure and data concurrently with program execution.

Fuchs, W. Kent

1986-01-01

106

The Concert system - Compiler and runtime technology for efficient concurrent object-oriented programming  

NASA Technical Reports Server (NTRS)

Concurrent object-oriented languages, particularly fine-grained approaches, reduce the difficulty of large scale concurrent programming by providing modularity through encapsulation while exposing large degrees of concurrency. Despite these programmability advantages, such languages have historically suffered from poor efficiency. This paper describes the Concert project whose goal is to develop portable, efficient implementations of fine-grained concurrent object-oriented languages. Our approach incorporates aggressive program analysis and program transformation with careful information management at every stage from the compiler to the runtime system. The paper discusses the basic elements of the Concert approach along with a description of the potential payoffs. Initial performance results and specific plans for system development are also detailed.

Chien, Andrew A.; Karamcheti, Vijay; Plevyak, John; Sahrawat, Deepak

1993-01-01

107

Hypothyroidism as a Consequence of Intensity-Modulated Radiotherapy With Concurrent Taxane-Based Chemotherapy for Locally Advanced Head-and-Neck Cancer  

SciTech Connect

Purpose: To conduct a retrospective review of 168 consecutively treated locally advanced head-and-neck cancer (LAHNC) patients treated with intensity-modulated radiotherapy (IMRT)/chemotherapy, to determine the rate and risk factors for developing hypothyroidism. Methods and Materials: Intensity-modulated radiotherapy was delivered in 33 daily fractions to 69.3 Gy to gross disease and 56.1 Gy to clinically normal cervical nodes. Dose-volume histograms (DVHs) of IMRT plans were used to determine radiation dose to thyroid and were compared with DVHs using conventional three-dimensional radiotherapy (3D-RT) in 10 of these same patients randomly selected for replanning and with DVHs of 16 patients in whom the thyroid was intentionally avoided during IMRT. Weekly paclitaxel (30 mg/m{sup 2}) and carboplatin area under the curve-1 were given concurrently with IMRT. Results: Sixty-one of 128 evaluable patients (47.7%) developed hypothyroidism after a median of 1.08 years after IMRT (range, 2.4 months to 3.9 years). Age and volume of irradiated thyroid were associated with hypothyroidism development after IMRT. Compared with 3D-RT, IMRT with no thyroid dose constraints resulted in significantly higher minimum, maximum, and median dose (p < 0.0001) and percentage thyroid volume receiving 10, 20, and 60 Gy (p < 0.05). Compared with 3D-RT, IMRT with thyroid dose constraints resulted in lower median dose and percentage thyroid volume receiving 30, 40, and 50 Gy (p < 0.005) but higher minimum and maximum dose (p < 0.005). Conclusions: If not protected, IMRT for LAHNC can result in higher radiation to the thyroid than with conventional 3D-RT. Techniques to reduce dose and volume of radiation to thyroid tissue with IMRT are achievable and recommended.

Diaz, Roberto; Jaboin, Jerry J.; Morales-Paliza, Manuel [Department of Radiation Oncology, Nashville, TN (United States); Koehler, Elizabeth [Division of Cancer Biostatistics, Department of Biostatistics, Nashville, TN (United States); Phillips, John G.; Stinson, Scott [Department of Radiation Oncology, Nashville, TN (United States); Gilbert, Jill; Chung, Christine H.; Murphy, Barbara A. [Section of Hematology/Oncology, Department of Medicine, Nashville, TN (United States); Yarbrough, Wendell G. [Department of Otorynolaryngology, Vanderbilt University Medical Center, Nashville, TN (United States); Murphy, Patrick B. [Tennessee Oncology, Franklin, TN (United States); Shyr, Yu [Division of Cancer Biostatistics, Department of Biostatistics, Nashville, TN (United States); Cmelak, Anthony J., E-mail: anthony.cmelak@vanderbilt.ed [Department of Radiation Oncology, Nashville, TN (United States)

2010-06-01

108

Sequential chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in patients with stage I/II extranodal natural killer/T-cell lymphoma, nasal type  

PubMed Central

Background The purpose of this report is to summarize our clinical experience of patients with stage I/II extranodal natural killer (NK)/T-cell lymphoma, nasal type, treated using sequential chemotherapy followed by radiotherapy (SCRT) or concurrent chemoradiotherapy (CCRT). Methods Forty-three patients with stage I/II extranodal NK/T-cell lymphoma, nasal type, who received SCRT (16 patients) or CCRT (27 patients) were included in the present analysis. Results The median follow-up time was 39 months (range, 4-171 months) for all patients, 77 months (range, 4-171 months) for the SCRT group, and 31 months (range, 6-132 months) for the CCRT group. There were no statistically significant differences between the SCRT and CCRT groups with regard to the 3-year progression-free survival (PFS) (56% vs. 41%, P=0.823) and 3-year overall survival (OS) (75% vs. 59%, P=0.670). Univariate analysis revealed that patients with tumors confined to the nasal cavity and patients achieved complete remission had better PFS and OS rates, regardless of the treatment sequence. Multivariate analysis revealed that patients with tumors confined to the nasal cavity and patients aged ?60 years had better OS rates. Conclusion The effect of SCRT and CCRT are similar in terms of survival outcomes of patients with stage I/II extranodal NK/T-cell lymphoma, nasal type. Our results show that tumors confined to the nasal cavity and an age ?60 years were associated with a better prognosis.

Lee, Jieun; Park, Young Je; Lee, Nam Kwon

2013-01-01

109

Phase II study of induction chemotherapy with gemcitabine and vinorelbine followed by concurrent chemoradiotherapy with oral etoposide and cisplatin in patients with inoperable stage III non-small-cell lung cancer  

SciTech Connect

Purpose: For locoregionally advanced inoperable non-small-cell lung cancer (NSCLC), concurrent chemoradiotherapy has become a standard therapy. We conducted a Phase II trial to examine the efficacy and toxicity of adding gemcitabine and vinorelbine induction chemotherapy to concurrent chemoradiotherapy with oral etoposide and cisplatin. Methods and Materials: Eligibility included inoperable clinical Stage III NSCLC without pleural effusion, ECOG performance status 0-1, and weight loss {<=}5%. Induction chemotherapy consisted of three cycles of gemcitabine 1,000 mg/m{sup 2} and vinorelbine 30 mg/m{sup 2}, each given i.v. on Days 1 and 8, every 3 weeks. During once-daily thoracic radiotherapy (1.8 Gy/day, total 63 Gy), two cycles of oral etoposide (100 mg on Days 1-5 and 8-12) plus cisplatin (50 mg/m{sup 2} on Days 1 and 8) were given concurrently 4 weeks apart. Results: Between April 2002 and November 2003, 42 patients were enrolled and 40 were included in response and toxicity evaluation. The median age was 59 years and 13 patients had IIIA and 27 had IIIB; 24 had squamous ca, 12 had adenocarcinoma, and 4 had others. Objective tumor responses were obtained in 29 patients (72.5%), including 18 (45.0%) after induction chemotherapy. After a median follow-up of 23.8 months, the median survival time and progression-free survival was 23.2 months and 10.9 months, respectively, with 2-year survival rate of 43.9%. For the patients with supraclavicular nodal involvement, the median survival time was 11.8 months with 2-year survival rate of 16.7%, whereas the corresponding figures were 27.8 months and 52.0%, respectively, for those without supraclavicular nodal involvement. Toxicity of induction chemotherapy was mild and well tolerated. However, concurrent chemoradiotherapy was associated with G3/4 hematologic toxicity in 75.7%, G3 esophagitis in 24.2%, and two treatment-related deaths. There were nonlife-threatening late toxicities in additional 6 patients. Conclusions: Induction chemotherapy with gemcitabine and vinorelbine followed by concurrent chemoradiotherapy with etoposide and cisplatin showed very promising survival in patients with Stage III NSCLC, especially in those without supraclavicular nodal involvement, which warrants further evaluation.

Lee, Dae Ho [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Han, Ji-Youn [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Cho, Kwan Ho [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Pyo, Hong Ryull [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kim, Hyae Young [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Yoon, Sung Jin B.S. [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Lee, Jin Soo [Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of)]. E-mail: jslee@ncc.re.kr

2005-11-15

110

Semantics of concurrent systems: a modular fixed-point trace approach  

Microsoft Academic Search

A method for finding the set of processes generated by a concurrent system (the behaviour of a system) in modular way is presented. A system is decomposed into modules with behaviours assumed to be known and then the behaviours are successively put together giving finally the initial system behaviour. It is shown that there is much of freedom in choice

Antoni W. Mazurkiewicz; Warszawa Poland

1984-01-01

111

Perioperative Systemic Chemotherapy for Appendiceal Mucinous Carcinoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy  

PubMed Central

Background The role of systemic chemotherapy (SC) in conjunction with cytoreductive surgery (CS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in appendiceal mucinous carcinoma peritonei (MCP) is unknown. Methods A retrospective review (1999–2011) of MCP patients who had undergone CS/HIPEC with or without perioperative SC. Results Twenty-two low-grade MCP patients treated with CS/HIPEC and SC were matched to patients who received CS/HIPEC alone. Median overall survival (OS) was 107 months for patients treated with perioperative SC compared to 72 without (P = 0.46). CS/HIPEC was performed on 109 patients with high-grade MCP: 70 were treated with perioperative SC, while 39 were not. Median OS (22.1 vs. 19.6 months, P = 0.74) and progression-free survival (PFS) (10.9 vs. 7.0 months, P = 0.47) were similar in patients treated with SC compared to CS/HIPEC alone. Progression while on pre-operative SC was seen in eight patients (17%), while four (8%) had a partial response. Treatment with postoperative SC was associated with longer PFS (13.6 months) compared to pre-operative SC (6.8 months, P < 0.01) and CS/HIPEC alone (7.0 months, P = 0.03). Conclusions Post-operative SC appears to improve PFS in patients with high-grade appendiceal MCP treated with CS/HIPEC. In contrast, there is no evidence to support the routine use of perioperative SC in low-grade disease.

Blackham, Aaron U.; Swett, Katrina; Eng, Cathy; Sirintrapun, Joseph; Bergman, Simon; Geisinger, Kim R; Votanopoulos, Konstantinos; Stewart, John H.; Shen, Perry; Levine, Edward A.

2014-01-01

112

Formalism to Describe Concurrent Nondeterministic Systems and an Application of It by Analyzing Systems for Danger of Deadlock.  

National Technical Information Service (NTIS)

A formalism is introduced to describe the behavior of systems built out of concurrently running mechanisms. The central notion in this formalism is called process. It is used to specify the behavior of these systems. Criteria to differentiate between spec...

R. J. Huisintveld

1988-01-01

113

Renormalization of concurrence: The application of the quantum renormalization group to quantum-information systems  

SciTech Connect

We have combined the idea of renormalization group and quantum-information theory. We have shown how the entanglement or concurrence evolve as the size of the system becomes large, i.e., the finite size scaling is obtained. Moreover, we introduce how the renormalization-group approach can be implemented to obtain the quantum-information properties of a many-body system. We have obtained the concurrence as a measure of entanglement, its derivatives and their scaling behavior versus the size of system for the one-dimensional Ising model in transverse field. We have found that the derivative of concurrence between two blocks each containing half of the system size diverges at the critical point with the exponent, which is directly associated with the divergence of the correlation length.

Kargarian, M. [Physics Department, Sharif University of Technology, Tehran 11155-9161 (Iran, Islamic Republic of); Jafari, R. [Institute for Advanced Studies in Basic Sciences, Zanjan 45195-1159 (Iran, Islamic Republic of); Institute for Studies in Theoretical Physics and Mathematics, Tehran 19395-5531 (Iran, Islamic Republic of); Langari, A. [Physics Department, Sharif University of Technology, Tehran 11155-9161 (Iran, Islamic Republic of); Institute for Studies in Theoretical Physics and Mathematics, Tehran 19395-5531 (Iran, Islamic Republic of)

2007-12-15

114

Integrated System-Level Optimization for Concurrent Engineering With Parametric Subsystem Modeling  

NASA Technical Reports Server (NTRS)

The introduction of concurrent design practices to the aerospace industry has greatly increased the productivity of engineers and teams during design sessions as demonstrated by JPL's Team X. Simultaneously, advances in computing power have given rise to a host of potent numerical optimization methods capable of solving complex multidisciplinary optimization problems containing hundreds of variables, constraints, and governing equations. Unfortunately, such methods are tedious to set up and require significant amounts of time and processor power to execute, thus making them unsuitable for rapid concurrent engineering use. This paper proposes a framework for Integration of System-Level Optimization with Concurrent Engineering (ISLOCE). It uses parametric neural-network approximations of the subsystem models. These approximations are then linked to a system-level optimizer that is capable of reaching a solution quickly due to the reduced complexity of the approximations. The integration structure is described in detail and applied to the multiobjective design of a simplified Space Shuttle external fuel tank model. Further, a comparison is made between the new framework and traditional concurrent engineering (without system optimization) through an experimental trial with two groups of engineers. Each method is evaluated in terms of optimizer accuracy, time to solution, and ease of use. The results suggest that system-level optimization, running as a background process during integrated concurrent engineering sessions, is potentially advantageous as long as it is judiciously implemented.

Schuman, Todd; DeWeck, Oliver L.; Sobieski, Jaroslaw

2005-01-01

115

Usefulness of Interim FDG-PET After Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Sequential Induction Chemotherapy Followed by Concurrent Chemoradiotherapy  

SciTech Connect

Purpose: Induction chemotherapy (ICT) has been used to select patients for organ preservation and determine subsequent treatments in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Still, the clinical outcomes of LASCCHN patients who showed response to ICT are heterogeneous. We evaluated the efficacy of interim 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) after ICT in this specific subgroup of LASCCHN patients who achieved partial response (PR) after ICT to predict clinical outcomes after concurrent chemoradiotherapy (CCRT). Methods and Materials: Twenty-one patients with LASCCHN who showed PR to ICT by Response Evaluation Criteria In Solid Tumors before definitive CCRT were chosen in this retrospective analysis. FDG-PET was performed before and 2-4 weeks after ICT to assess the extent of disease at baseline and the metabolic response to ICT, respectively. We examined the correlation of the metabolic response by the percentage decrease of maximum standardized uptake value (SUVmax) on the primary tumor or lymph node after ICT or a specific threshold of SUVmax on interim FDG-PET with clinical outcomes including complete response (CR) rate to CCRT, progression-free survival (PFS), and overall survival (OS). Results: A SUVmax of 4.8 on interim FDG-PET could predict clinical CR after CCRT (100% vs. 20%, p = 0.001), PFS (median, not reached vs. 8.5 mo, p < 0.001), and OS (median, not reached vs. 12.0 months, p = 0.001) with a median follow-up of 20.3 months in surviving patients. A 65% decrease in SUVmax after ICT from baseline also could predict clinical CR after CCRT (100% vs. 33.3%, p = 0.003), PFS (median, not reached vs. 8.9 months, p < 0.001) and OS (median, not reached vs. 24.4 months, p = 0.001) of the patients. Conclusion: These data suggest that interim FDG-PET after ICT might be a useful determinant to predict clinical outcomes in patients with LASCCHN receiving sequential ICT followed by CCRT.

Yoon, Dok Hyun; Cho, Yoojin [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Sang Yoon; Nam, Soon Yuhl; Choi, Seung-Ho; Roh, Jong-Lyel [Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Lee, Sang-wook; Song, Si Yeol [Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Lee, Jeong Hyun [Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Jae Seung [Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Cho, Kyung-Ja [Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Kim, Sung-Bae, E-mail: sbkim3@amc.seoul.kr [Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

2011-09-01

116

Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy  

PubMed Central

Background To evaluate the association between the clinical, dosimetric factors and severe acute radiation pneumonitis (SARP) in patients with locally advanced non-small cell lung cancer (LANSCLC) treated with concurrent chemotherapy and intensity-modulated radiotherapy (IMRT). Methods We analyzed 94 LANSCLC patients treated with concurrent chemotherapy and IMRT between May 2005 and September 2006. SARP was defined as greater than or equal 3 side effects and graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. The clinical and dosimetric factors were analyzed. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between clinical, dosimetric factors and SARP. Results Median follow-up was 10.5 months (range 6.5-24). Of 94 patients, 11 (11.7%) developed SARP. Univariate analyses showed that the normal tissue complication probability (NTCP), mean lung dose (MLD), relative volumes of lung receiving more than a threshold dose of 5-60 Gy at increments of 5 Gy (V5-V60), chronic obstructive pulmonary disease (COPD) and Forced Expiratory Volume in the first second (FEV1) were associated with SARP (p < 0.05). In multivariate analysis, NTCP value (p = 0.001) and V10 (p = 0.015) were the most significant factors associated with SARP. The incidences of SARP in the group with NTCP > 4.2% and NTCP ?4.2% were 43.5% and 1.4%, respectively (p < 0.01). The incidences of SARP in the group with V10 ?50% and V10 >50% were 5.7% and 29.2%, respectively (p < 0.01). Conclusions NTCP value and V10 are the useful indicators for predicting SARP in NSCLC patients treated with concurrent chemotherapy and IMRT.

2010-01-01

117

Temporal predicate transition nets—a new formalism for specifying and verifying concurrent systems  

Microsoft Academic Search

In this paper, a new type of high-level Petri nets is defined, which is a combination of predicate transition nets and first order temporal logic. By combining these two formalisms together, we can explicitly specify the structure, and specify and verify various properties of concurrent systems in the same framework, which we cannot achieve by using either one of the

Xudong He

1992-01-01

118

Scheduling Support for Concurrency and Parallelism in the Mach Operating System  

Microsoft Academic Search

Changes in the use of multiprocessors are placing new demands on operating system schedulers. This article describes some of the new challenges posed by parallel and concurrent applications, and introduces techniques developed by the Mach project to meet these challenges. An overview of the techniques of timesharing scheduling and a description of the Mach scheduler are also included. This article

David L. Black

1990-01-01

119

Designing for operations: Towards a sociotechnical systems and cognitive engineering approach to concurrent engineering  

Microsoft Academic Search

In the practice of concurrent engineering, the factors that are considered early in the product design process include manufacturability, assembly, and cost. A set of issues that are not typically considered revolve around the operational requirements for human workers in the manufacturing system. What tasks will human workers accomplish? How will these tasks be organized and coordinated? What information and

Patricia M. Jones

1995-01-01

120

Intelligent quality function deployment system in concurrent engineering environment  

NASA Astrophysics Data System (ADS)

This paper describes work being undertaken in the development of an intelligent distributed quality function deployment (IDQFD) system, which supports product design team to transfer and deployment the `Voice of Customer' through `House of Quality' into the various stages of product planning, engineering and manufacturing. The requirement modeling of products, the optimization in QFD are indicated. The framework of the system, including QFD tools and platform for distributed collaborative work in QFD, is described. The strategy and methods for the collaboration processing in QFD process are presented. It shows promise for application in practice.

Lin, Zhi-Hang; Che, Ada

1998-10-01

121

Dynamic data structures and concurrency in a real-time data acquisition system  

SciTech Connect

We report on our efforts in developing an innovative real-time data acquisition system that makes extensive use of dynamic data structures, concurrency and state machine features. The Data Acquisition Command Language developed at the Los Alamos Weapons Neutron Research (WNR) Facility is a Pascal-based system that incorporates these features to maximize system performance, reliability and adapability while supporting a consistent, familiar and comfortable user interface. The details and benefits of the implementation philosophy and underlying structures are discussed.

Cort, G.; Goldstone, J.A.; Nelson, R.O.; Poore, R.V.; Miller, L.; Barrus, D.M.

1985-01-01

122

Concurrent synaptic and systems memory consolidation during sleep.  

PubMed

Memories are consolidated during sleep by two apparently antagonistic processes: (1) reinforcement of memory-specific cortical interactions and (2) homeostatic reduction in synaptic efficiency. Using fMRI, we assessed whether episodic memories are processed during sleep by either or both mechanisms, by comparing recollection before and after sleep. We probed whether LTP influences these processes by contrasting two groups of individuals prospectively recruited based on BDNF rs6265 (Val66Met) polymorphism. Between immediate retrieval and delayed testing scheduled after sleep, responses to recollection increased significantly more in Val/Val individuals than in Met carriers in parietal and occipital areas not previously engaged in retrieval, consistent with "systems-level consolidation." Responses also increased differentially between allelic groups in regions already activated before sleep but only in proportion to slow oscillation power, in keeping with "synaptic downscaling." Episodic memories seem processed at both synaptic and systemic levels during sleep by mechanisms involving LTP. PMID:23761912

Mascetti, Laura; Foret, Ariane; Schrouff, Jessica; Muto, Vincenzo; Dideberg, Vinciane; Balteau, Evelyne; Degueldre, Christian; Phillips, Christophe; Luxen, André; Collette, Fabienne; Bours, Vincent; Maquet, Pierre

2013-06-12

123

A Federated UDDI System for Concurrent Access to Service Data  

Microsoft Academic Search

With service-oriented environments, the real-time acquisition of new software functions relies on dynamic service discovery with the Universal Description, Discovery and Integration (UDDI) protocol. Both the fluidity of services and updates in service offerings affect service users via access operations of service data in registry repositories conformed to the protocol. One valuable usage of UDDI-specific systems is to guarantee real

Qianhui Liang; Jen-Yao Chung

2008-01-01

124

TwoTowers: A Tool Integrating Functional and Performance Analysis of Concurrent Systems  

Microsoft Academic Search

We present TwoTowers, a tool for analyzing functional and performance properties of concurrent systems expressed as terms in the s tochastically timed reward process algebra EMPA . TwoTowers builds on two existing tools, CWB-NC and MarCA, that have been retargeted to carry out functional and perfor mance analysis (respectively) of EMPA system specifications. As an example, we describe the applic

Marco Bernardo; Steve Sims; W. Stewart

1998-01-01

125

Concurrent Prolog  

SciTech Connect

This book discusses Concurrent Prolog which is a logic programming language designed for concurrent programming and parallel execution. The contributions in this book summarize the development of the language and present techniques, applications, and implementation. Some of the topics covered include: programming techniques; systolic programming; object oriented programming in Concurrent Prolog; merge operators; bounded buffers; distributed programming, applications; and quadtrees in Concurrent Prolog.

Shapiro, E.Y.

1986-01-01

126

Dose escalation of accelerated hypofractionated three-dimensional conformal radiotherapy (at 3 Gy/fraction) with concurrent vinorelbine and carboplatin chemotherapy in unresectable stage III non-small-cell lung cancer: a phase I trial  

PubMed Central

Background Accelerated hypofractionated radiotherapy can shorten total treatment time and overcome the accelerated repopulation of tumour cells during radiotherapy. This therapeutic approach has demonstrated good efficacy in the treatment of locally advanced non-small-cell lung cancer (NSCLC). However, the optimal fractionation scheme remains uncertain. The purpose of this phase I trial was to explore the maximum tolerated dose (MTD) of accelerated hypofractionated three-dimensional conformal radiotherapy (3-DCRT) (at 3 Gy/fraction) administered in combination with concurrent vinorelbine (NVB) and carboplatin (CBP) chemotherapy for unresectable stage III NSCLC. Methods Previously untreated cases of unresectable stage III NSCLC received accelerated hypofractionated 3-DCRT, delivered at 3 Gy per fraction, once daily, with five fractions per week. The starting dose was 66 Gy and an increment of 3 Gy was utilized. Higher doses continued to be tested in patient groups until the emergence of dose-limiting toxicity (DLT). The MTD was regarded as the dose that was one step below the dose at which DLT occurred. Patients received at least one cycle of a concurrent two-drug chemotherapy regimen of NVB and CBP. Results A total of 13 patients were enrolled and progressed through three dose escalation groups: 66 Gy, 69 Gy, and 72 Gy. No treatment-related deaths occurred. The major adverse events included radiation oesophagitis, radiation pneumonitis, and neutropenia. Nausea, fatigue, and anorexia were commonly observed, although the magnitude of these events was typically relatively minor. Among the entire group, four instances of DLT were observed, including two cases of grade 3 radiation oesophagitis, one case of grade 3 radiation pneumonitis, and one case of grade 4 neutropenia. All of these cases of DLT occurred in the 72 Gy group. Therefore, 72 Gy was designated as the DLT dose level, and the lower dose of 69 Gy was regarded as the MTD. Conclusions For unresectable stage III NSCLC 69 Gy (at 3 Gy/fraction) was the MTD of accelerated hypofractionated 3-DCRT administered in combination with concurrent NVB and CBP chemotherapy. The toxicity of this chemoradiotherapy regimen could be tolerated. A phase II trial is recommended to further evaluate the efficacy and safety of this regimen.

2013-01-01

127

Sequential versus concurrent computation of complex model systems for medical decision support.  

PubMed

Medical Decision Support Systems employ mathematical models to optimize therapy settings. The mathematical models are used to predict patient reactions towards alteration in the therapy regime. This prediction should not be limited to one detail but should feature a broad picture. A previously proposed framework is able to dynamically combine submodels of three model families (respiratory mechanics, gas exchange and cardiovascular dynamics) to form a complex, interacting model system. When concurrent computation of the combined submodels is employed, tests exhibited high computing costs. Therefore, a sequential computing approach is introduced. Thereby, direct interaction between the submodels is not applicable as all submodels are computed individually. To simulate submodel interaction, interface signals that are normally present in the concurrent approach were precalculated using reduced models of respiratory mechanics and cardiovascular dynamics. Evaluation of the new approach showed that results feature a discrepancy lower than 2.5% compared to the results computed by the concurrent approach. Simulation error could be decreased to 2% by improving the precalculation of the interface signals. Computing costs have been decreased by a factor of 17. PMID:22254268

Kretschmer, Joern; Moeller, Knut

2011-01-01

128

A Phase I/II trial of radiotherapy concurrent with TS-1 plus cisplatin in patients with clinically resectable type 4 or large type 3 gastric cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group OGSG1205.  

PubMed

A Phase I/II trial of radiotherapy administered concurrently with TS-1 plus cisplatin has been initiated in Japanese patients with clinical resectable type 4 or large type 3 gastric cancer. The aim of this trial is to determine the recommended dose of TS-1 and cisplatin combined with radiotherapy at a fixed dose in the Phase I study, and to evaluate the efficacy and safety in the Phase II study. The primary endpoint for Phase II is the pathological complete response rate, assessed using surgically resected specimens. Secondary endpoints are the response rate, progression-free survival, overall survival, operation transitional rate, R0 resection rate, rate of treatment completion, rate of down-staging and rates of postoperative complications and adverse events. In Phase II, a total of 30 patients will be enrolled in the Osaka Gastrointestinal Cancer Chemotherapy Study Group trial over a period of 6 years. PMID:23447812

Imano, Motohiro; Furukawa, Hiroshi; Yokokawa, Masaki; Nishimura, Yasumasa; Kurokawa, Yukinori; Satoh, Taroh; Sakai, Daisuke; Yasuda, Takushi; Imamoto, Haruhiko; Tujinaka, Toshimasa; Shimokawa, Toshio; Shiozaki, Hitoshi

2013-04-01

129

Prognosis of non-small cell lung cancer patients with bone oligometastases treated concurrently with thoracic three-dimensional radiotherapy and chemotherapy  

PubMed Central

Background To evaluate the efficacy of three-dimensional radiotherapy for non-small cell lung cancer (NSCLC) patients with bone metastases. Methods Clinical data for 95 NSCLC patients with bone metastases were collected and prognostic factors were analyzed. All patients received radiation to their thoracic primary tumor and ?2 cycles of chemotherapy. Results Of these 95 patients, 47 patients had only bone metastases and 48 had both bone metastases and other organ metastases. Univariate analysis showed that factors that statistically significantly contributed to patients having longer overall survival (OS) included receiving a radiation dose to the primary tumor ?63 Gy, responding to treatment and receiving ?4 cycles of chemotherapy (p?=?0.001, p?=?0.037 and p?=?0.009, respectively). A radiation dose to the primary tumor ?63 Gy remained significant for patients with bone metastases only as well as those with bone and other organ metastases when they were analyzed separately (p?=?0.045 and p?=?0.012, respectively). For patients with bone metastases only, those with T1-2 tumors had longer OS than those with T3-4 (p?=?0.048); and patients who received ?4 cycles chemotherapy compared with those who received <4 cycles had similar OS (p?=?0.385). On multivariate analysis, only a radiation dose ?63 Gy (p?=?0.028) and having only bone metastases (p?=?0.006) were independent prognostic factors for better OS. Conclusions A radiation dose to the primary tumor ?63 Gy and having only bone metastases were associated with better OS in NSCLC patients with bone metastases. For patients with bone metastases only, besides radiation dose, T status was also correlated with OS, whereas the number of chemotherapy cycles was not. Therefore, aggressive thoracic radiation may play an important role in improving OS.

2014-01-01

130

Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.  

PubMed

Systemic chemotherapy has been relatively ineffective in the treatment of malignant brain tumors even though systemic chemotherapy drugs are small molecules that can readily extravasate across the porous blood-brain tumor barrier of malignant brain tumor microvasculature. Small molecule systemic chemotherapy drugs maintain peak blood concentrations for only minutes, and therefore, do not accumulate to therapeutic concentrations within individual brain tumor cells. The physiologic upper limit of pore size in the blood-brain tumor barrier of malignant brain tumor microvasculature is approximately 12 nanometers. Spherical nanoparticles ranging between 7 nm and 10 nm in diameter maintain peak blood concentrations for several hours and are sufficiently smaller than the 12 nm physiologic upper limit of pore size in the blood-brain tumor barrier to accumulate to therapeutic concentrations within individual brain tumor cells. Therefore, nanoparticles bearing chemotherapy that are within the 7 to 10 nm size range can be used to deliver therapeutic concentrations of small molecule chemotherapy drugs across the blood-brain tumor barrier into individual brain tumor cells. The initial therapeutic efficacy of the Gd-G5-doxorubicin dendrimer, an imageable nanoparticle bearing chemotherapy within the 7 to 10 nm size range, has been demonstrated in the orthotopic RG-2 rodent malignant glioma model. Herein I discuss this novel strategy to improve the effectiveness of systemic chemotherapy for the treatment of malignant brain tumors and the therapeutic implications thereof. PMID:19723323

Sarin, Hemant

2009-01-01

131

Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study  

SciTech Connect

Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m{sup 2}, and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade {>=}3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade {>=}3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

Saitoh, Jun-Ichi, E-mail: junsaito@sannet.ne.jp [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Sakai, Hiroshi; Kurimoto, Futoshi [Division of Respiratory Disease, Saitama Cancer Center, Saitama (Japan); Kato, Shingo [Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Shibuya, Kei [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma (Japan)

2012-04-01

132

Concurrent Mission and Systems Design at NASA Glenn Research Center: The Origins of the COMPASS Team  

NASA Technical Reports Server (NTRS)

Established at the NASA Glenn Research Center (GRC) in 2006 to meet the need for rapid mission analysis and multi-disciplinary systems design for in-space and human missions, the Collaborative Modeling for Parametric Assessment of Space Systems (COMPASS) team is a multidisciplinary, concurrent engineering group whose primary purpose is to perform integrated systems analysis, but it is also capable of designing any system that involves one or more of the disciplines present in the team. The authors were involved in the development of the COMPASS team and its design process, and are continuously making refinements and enhancements. The team was unofficially started in the early 2000s as part of the distributed team known as Team JIMO (Jupiter Icy Moons Orbiter) in support of the multi-center collaborative JIMO spacecraft design during Project Prometheus. This paper documents the origins of a concurrent mission and systems design team at GRC and how it evolved into the COMPASS team, including defining the process, gathering the team and tools, building the facility, and performing studies.

McGuire, Melissa L.; Oleson, Steven R.; Sarver-Verhey, Timothy R.

2012-01-01

133

Penn researchers repair immune system in leukemia patients following chemotherapy:  

Cancer.gov

A new treatment using leukemia patients’ own infection-fighting cells appears to protect them from infections and cancer recurrence following treatment with fludarabine-based chemotherapy, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

134

Central nervous system as sanctuary site of relapse in patients treated with chemotherapy for metastatic testicular cancer  

Microsoft Academic Search

Isolated central nervous system relapse in patients treated successfully with cisplatin-based chemotherapy for testicular cancer has been described infrequently. In a retrospective analysis we identified this complication in six of 417 patients. Five of the six patients had advanced pulmonary dissemination at onset of chemotherapy, and post-chemotherapy surgery did not reveal viable tumour tissue in any of these cases. All

Arthur Gerl; Christoph Clemm; Peter Kohl; Andreas Schalhorn; Wolfgang Wilrnanns

1994-01-01

135

Methods for design and evaluation of integrated hardware/software systems for concurrent computation  

NASA Technical Reports Server (NTRS)

Two testbed programming environments to support the evaluation of a large range of parallel architectures have been implemented under the program Parallel Implementation of Scientific Computing Environments (PISCES). The PISCES 1 environment was applied to two areas of aerospace interest: a sparse matrix iterative equation solver and a dynamic scene analysis system. Currently, the NICE/SPAR testbed system for structural analysis is being modified for parallel operation under PISCES 2; the PISCES 1 applications are also being adapted for PISCES 2. A new formal model of concurrent computation has been developed, based on the mathematical system known as H graph semantics together with a timed Petri net model of the parallel aspects of a system.

Pratt, Terrence W.

1987-01-01

136

Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system.  

PubMed

Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer. PMID:24792568

Zhou, Lin; Zhou, Lin; Wei, Shaohua; Ge, Xuefeng; Zhou, Jiahong; Jiang, Huijun; Li, Fuyou; Shen, Jian

2014-06-01

137

System front-end design for concurrent acquisition of electroencephalograms and EIT data  

NASA Astrophysics Data System (ADS)

There is recently considerable interest in medical imaging to combine recording of bioelectrical signals with imaging procedures. For example, electroencephalograms (EEGs) recorded during functional magnetic resonance imaging are increasingly being used for neurological and behavioural research. Concurrent acquisition of EEGs and electrical impedance tomography (EIT) data have been suggested as a non invasive technique that could help localize the area of the brain responsible for seizures in epileptic patients awaiting resective surgery. Despite reasonably distinct spectra, EEGs and EIT signals are difficult to record simultaneously because of their very different amplitudes. In this paper, we describe the front-end of a 24-channel system designed to acquire both signals from the same set of scalp electrodes using time-division multiplexing. We have developped a 10-layer 20×15 cm printed circuit board of the front-end and are currently performing circuit characterization tests. System performance parameters and in vivo images will be presented at the conference.

Guardo, R.; Jehanne-Lacasse, J.; Moumbe, A. P.; Gagnon, H.

2010-04-01

138

Correctness of Concurrent Executions of Closed Nested Transactions in Transactional Memory Systems  

NASA Astrophysics Data System (ADS)

A generally agreed upon requirement for correctness of concurrent executions in Transactional Memory systems is that all transactions including the aborted ones read consistent values. Opacity is a recently proposed correctness criterion that satisfies the above requirement. Our first contribution in this paper is extending the opacity definition for closed nested transactions. Secondly, we define conflicts appropriate for optimistic executions which are commonly used in Software Transactional Memory systems. Using these conflicts, we define a restricted, conflict-preserving, class of opacity for closed nested transactions the membership of which can be tested in polynomial time. As our third contribution, we propose a correctness criterion that defines a class of schedules where aborted transactions do not affect consistency of the other transactions. We define a conflict-preserving subclass of this class as well. Both the class definitions and the conflict definition are new for nested transactions.

Peri, Sathya; Vidyasankar, Krishnamurthy

139

Post-game analysis: An initial experiment for heuristic-based resource management in concurrent systems  

NASA Technical Reports Server (NTRS)

In concurrent systems, a major responsibility of the resource management system is to decide how the application program is to be mapped onto the multi-processor. Instead of using abstract program and machine models, a generate-and-test framework known as 'post-game analysis' that is based on data gathered during program execution is proposed. Each iteration consists of (1) (a simulation of) an execution of the program; (2) analysis of the data gathered; and (3) the proposal of a new mapping that would have a smaller execution time. These heuristics are applied to predict execution time changes in response to small perturbations applied to the current mapping. An initial experiment was carried out using simple strategies on 'pipeline-like' applications. The results obtained from four simple strategies demonstrated that for this kind of application, even simple strategies can produce acceptable speed-up with a small number of iterations.

Yan, Jerry C.

1987-01-01

140

Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study.  

PubMed

PURPOSE We started a phase II trial of induction chemotherapy and concurrent hyperfractionated chemoradiotherapy followed by either surgery or boost chemoradiotherapy in patients with advanced, stage III disease. The purpose is to achieve better survival in the surgery group with minimum morbidity and mortality. PATIENTS AND METHODS Patients treated from 1998 to 2002 with neoadjuvant chemoradiotherapy and surgical resection for stage III NSCLC were analyzed. The treatment consisted of four cycles of induction chemotherapy with carboplatin/paclitaxel followed by chemoradiotherapy with a reduced dose of carboplatin/paclitaxel and accelerated hyperfractionated radiotherapy with 1.5 Gy twice daily up to 45 Gy. After restaging, operable patients underwent thoracotomy. Inoperable patients received chemoradiotherapy up to 63 Gy. Study end points included resectability, pathologic response, and survival. Results One hundred twenty patients were enrolled; 25% patients had stage IIIA, 73% had stage IIIB, and 2% stage IV. After treatment, 47.5% had downstaging, 29.2% had stable disease, and 23.3% had progressive disease. Thirty patients (25%) were not eligible for operation because of progressive disease, stable disease, and/or functional deterioration with one treatment-related death. The 30-day mortality was 5% in patients who underwent operation. The 5-year survival rate for 120 patients was 21.7%, and it was 43.1% in patients with complete resection. In postoperative patients with stage N0 disease, 5-year survival was 53.3%; if stage N2 or N3 disease was still present, 5-year survival was 33.3%. CONCLUSION Staging and treatment with chemoradiotherapy and complete resection performed in experienced centers achieve acceptable morbidity and mortality. PMID:20100967

Friedel, Godehard; Budach, Wilfried; Dippon, Juergen; Spengler, Werner; Eschmann, Susanne Martina; Pfannenberg, Christina; Al-Kamash, Fawaz; Walles, Thorsten; Aebert, Hermann; Kyriss, Thomas; Veit, Stefanie; Kimmich, Martin; Bamberg, Michael; Kohlhaeufl, Martin; Steger, Volker; Hehr, Thomas

2010-02-20

141

Preoperative Concurrent Radiation Therapy and Chemotherapy for Bulky Stage IB2, IIA, and IIB Carcinoma of the Uterine Cervix With Proximal Parametrial Invasion  

SciTech Connect

Purpose: To evaluate toxicity, local tumor control, and survival after preoperative chemoradiation for operable bulky cervical carcinoma. Methods and Materials: Between December 1991 and July 2006, 92 patients with operable bulky stage IB2, IIA, and IIB cervical carcinoma without pelvic or para-aortic nodes on pretreatment imaging were treated. Treatment consisted of preoperative external beam pelvic radiation therapy (EBRT) and concomitant chemotherapy (CT) during the first and fourth weeks of radiation combining 5-fluorouracil and cisplatin. The pelvic radiation dose was 40.5 Gy over 4.5 weeks. EBRT was followed by low-dose rate uterovaginal brachytherapy with a total dose of 20 Gy in 62 patients. After a median rest period of 44 days, all patients underwent Class II modified radical hysterectomy with bilateral pelvic lymphadenectomy. Thirty patients who had not received preoperative uterovaginal brachytherapy underwent postoperative low-dose-rate vaginal brachytherapy at a dose of 20 Gy. The mean follow-up was 46 months. Results: Pathologic residual tumor was observed in 43 patients. After multivariate analysis, additional preoperative uterovaginal brachytherapy was the single significant predictive factor for pathologic complete response rate (p = 0.019). The 2- and 5-year disease-free survival (DFS) rates were 80.4% and 72.2%, respectively. Pathologic residual cervical tumor was the single independent factor decreasing the probability of DFS (p = 0.020). Acute toxicities were moderate. Two severe ureteral complications requiring surgical intervention were observed. Conclusions: Concomitant chemoradiation followed by surgery for operable bulky stage I-II cervical carcinoma without clinical lymph node involvement can be used with acceptable toxicity. Pathologic complete response increases the probability of DFS.

Huguet, Florence; Cojocariu, Oana-Maria [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Cancerest, GHU Est, Paris VI University, Paris (France); Levy, Pierre [Department of Public Health, Tenon Hospital A.P.-H.P., Cancerest, GHU Est, Paris VI University, Paris (France); Lefranc, Jean-Pierre [Department of Gynecologic Surgery, Pitie-Salpetriere Hospital A.P.-H.P., Paris (France); Darai, Emile [Department of Gynecology and Obstetrics, Tenon Hospital A.P.-H.P., Cancerest, GHU Est, Paris VI University, Paris (France); Jannet, Denis; Ansquer, Yan [Department of Gynecology and Obstetrics, Saint-Antoine Hospital A.P.-H.P., Paris (France); Lhuillier, Pierre-Eugene [Department of Gynecology and Obstetrics, Fontainebleau Hospital, Fontainebleau (France); Benifla, Jean-Louis [Department of Gynecology and Obstetrics, Rothschild Hospital A.P.-H.P., Paris (France); Seince, Nathalie [Department of Gynecology and Obstetrics, Jean Verdier Hospital, Bondy (France); Touboul, Emmanuel [Department of Radiation Oncology, Tenon Hospital A.P.-H.P., Cancerest, GHU Est, Paris VI University, Paris (France)], E-mail: emmanuel.touboul@tnn.aphp.fr

2008-12-01

142

Improving the Hadoop map\\/reduce framework to support concurrent appends through the BlobSeer BLOB management system  

Microsoft Academic Search

Hadoop is a reference software framework supporting the Map\\/Reduce programming model. It relies on the Hadoop Distributed File System (HDFS) as its primary storage system. Although HDFS does not offer support for concurrently appending data to existing files, we argue that Map\\/Reduce applications as well as other classes of applications can benefit from such a functionality. We provide support for

Diana Moise; Gabriel Antoniu; Luc Bougé

2010-01-01

143

Concurrent cost estimation as a tool for enhanced producibility—System development and applicability for producibility studies  

Microsoft Academic Search

The paper aims at presenting the thoughts behind concurrent cost estimation as a tool for engineering companies to obtain enhanced producibility for their products by the possibility of performing producibility studies. The two main parts of the paper are: the presentation of a method for system development, focusing on a number of general criteria of system development; and how such

Fredrik Elgh; Mikael Cederfeldt

2007-01-01

144

Independent Checkpointing and Concurrent Rollback for Recovery in Distributed Systems - An Optimistic Approach  

Microsoft Academic Search

A checkpoint algorithm is presented that benefits from the research in concurrency control, commit, and site recovery algorithms in transaction processing. In the authors' approach a number of checkpointing processes, a number of rollback processes, and computations on operational processes can proceed concurrently while tolerating the failure of an arbitrary number of processes. Each process takes checkpoints independently. During recovery

Bharat K. Bhargava; Shy-renn Lian

1988-01-01

145

Phase II Study of Accelerated High-Dose Radiotherapy With Concurrent Chemotherapy for Patients With Limited Small-Cell Lung Cancer: Radiation Therapy Oncology Group Protocol 0239  

SciTech Connect

Purpose: To investigate whether high-dose thoracic radiation given twice daily during cisplatin-etoposide chemotherapy for limited small-cell lung cancer (LSCLC) improves survival, acute esophagitis, and local control rates relative to findings from Intergroup trial 0096 (47%, 27%, and 64%). Patients and Methods: Patients were accrued over a 3-year period from 22 US and Canadian institutions. Patients with LSCLC and good performance status were given thoracic radiation to 61.2 Gy over 5 weeks (daily 1.8-Gy fractions on days 1-22, then twice-daily 1.8-Gy fractions on days 23-33). Cisplatin (60 mg/m{sup 2} IV) was given on day 1 and etoposide (120 mg/m{sup 2} IV) on days 1-3 and days 22-24, followed by 2 cycles of cisplatin plus etoposide alone. Patients who achieved complete response were offered prophylactic cranial irradiation. Endpoints included overall and progression-free survival; severe esophagitis (Common Toxicity Criteria v 2.0) and treatment-related fatalities; response (Response Evaluation Criteria in Solid Tumors); and local control. Results: Seventy-two patients were accrued from June 2003 through May 2006; 71 were evaluable (median age 63 years; 52% female; 58% Zubrod 0). Median survival time was 19 months; at 2 years, the overall survival rate was 36.6% (95% confidence interval [CI] 25.6%-47.7%), and progression-free survival 19.7% (95% CI 11.4%-29.6%). Thirteen patients (18%) experienced severe acute esophagitis, and 2 (3%) died of treatment-related causes; 41% achieved complete response, 39% partial response, 10% stable disease, and 6% progressive disease. The local control rate was 73%. Forty-three patients (61%) received prophylactic cranial irradiation. Conclusions: The overall survival rate did not reach the projected goal; however, rates of esophagitis were lower, and local control higher, than projected. This treatment strategy is now one of three arms of a prospective trial of chemoradiation for LSCLC (Radiation Therapy Oncology Group 0538/Cancer and Leukemia Group B 30610).

Komaki, Ritsuko, E-mail: rkomaki@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Paulus, Rebecca [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Ettinger, David S. [Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland (United States); Videtic, Gregory M.M. [Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio (United States); Bradley, Jeffrey D. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Glisson, Bonnie S. [Department of Thoracic/Head and Neck Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Langer, Corey J. [Thoracic Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Sause, William T. [Radiation Center, LDS Hospital, Salt Lake City, Utah (United States); Curran, Walter J. [Department of Radiation Oncology, Jefferson Medical College, Philadelphia, Pennsylvania (United States); Choy, Hak [Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas (United States)

2012-07-15

146

A handheld chemotherapy symptom management system: results from a preliminary outpatient field trial  

Microsoft Academic Search

A symptom management system was developed and implemented on personal digital assistants (PDAs) for use by cancer outpatients in their daily management of chemotherapy symptoms. The system allowed patients to record their symptoms at home and send these data to their cancer centre. Patients could view personalized self-care advice and more general medical information. In addition, cancer care nurses were

Marilyn Rose Mcgee; Philip D. Gray

2005-01-01

147

Bi-Level Integrated System Synthesis (BLISS) for Concurrent and Distributed Processing  

NASA Technical Reports Server (NTRS)

The paper introduces a new version of the Bi-Level Integrated System Synthesis (BLISS) methods intended for optimization of engineering systems conducted by distributed specialty groups working concurrently and using a multiprocessor computing environment. The method decomposes the overall optimization task into subtasks associated with disciplines or subsystems where the local design variables are numerous and a single, system-level optimization whose design variables are relatively few. The subtasks are fully autonomous as to their inner operations and decision making. Their purpose is to eliminate the local design variables and generate a wide spectrum of feasible designs whose behavior is represented by Response Surfaces to be accessed by a system-level optimization. It is shown that, if the problem is convex, the solution of the decomposed problem is the same as that obtained without decomposition. A simplified example of an aircraft design shows the method working as intended. The paper includes a discussion of the method merits and demerits and recommendations for further research.

Sobieszczanski-Sobieski, Jaroslaw; Altus, Troy D.; Phillips, Matthew; Sandusky, Robert

2002-01-01

148

Fault tolerant matrix arithmetic and signal processing on highly concurrent VLSI systems  

SciTech Connect

In the first part of this research, a very general matrix encoding scheme is proposed for achieving fault tolerance with low cost in matrix arithmetic and signal processing systems using linear arrays and fixed point number representation. Such arrays are believed to hold the most promise in VLSI computing structures for their flexibility, low cost, and applicability to many interesting algorithms. In floating point systems, roundoff errors may destroy the error correction capability of this encoding scheme. However, the encoding scheme combined with a data retry technique is shown to be useful and cost-effective for floating point systems. The Fast Fourier Transform (FFT) has long been a major analytical tool in such diverse fields as system analysis, digital filtering, power spectrum analysis, and communication theory. In this second part of this research, a concurrent error detection (CED) scheme with small hardware overhead is proposed for FFT networks that consist of (N/2-log/sub 2/N 2-point butterfly modules. A time redundancy method is used to locate the faulty modules. Finally multiplexer-demultiplexer type of switches incorporated in the design are used to effect reconfiguration.

Jou, J.Y.

1985-01-01

149

Effects of Neoadjuvant Intraperitoneal/Systemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer  

PubMed Central

Novel multidisciplinary treatment combined with neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS) and peritonectomy was developed. Ninety-six patients were enrolled. Peritoneal wash cytology was performed before and after NIPS through a port system. Patients were treated with 60?mg/m2 of oral S-1 for 21 days, followed by a 1-week rest. On days 1, 8, and 15, 30?mg/m2 of Taxotere and 30?mg/m2 of cisplatin with 500?mL of saline were introduced through the port. NIPS is done 2 cycles before surgery. Three weeks after NIPS, 82 patients were eligible to intend cytoreductive surgery (CRS) by gastrectomy + D2 dissection + periotnectomy to achieve complete cytoreduction. Sixty-eight patients showed positice cytology before NIPS, and the positive cytology results became negative in 47 (69%) patients after NIPS. Complete pathologic response on PC after NIPS was experienced in 30 (36.8%) patients. Stage migration was experienced in 12 patients (14.6%). Complete cytoreduction was achieved in 58 patients (70.7%). By the multivariate analysis, complete cytoreduction and pathologic response became a significantly good survival. However the high morbidity and mortality, stringent patient selection is important. The best indications of the therapy are patients with good pathologic response and PCI ? 6, which are supposed to be removed completely by peritonectomy.

Yonemura, Yutaka; Elnemr, Ayman; Endou, Yoshio; Ishibashi, Haruaki; Mizumoto, Akiyoshi; Miura, Masahiro; Li, Yan

2012-01-01

150

Concurrent replication of active logic blocks: A core solution for online testing and logic space defragmentation in reconfigurable systems  

Microsoft Academic Search

Partial and dynamically reconfigurable SRAM-based FPGAs (Field Programmable Gate Arrays) enable the implementation of reconfigurable systems hosting several applications simultaneously, which share the available resources according to the functional requirements that are present at any given moment. Time and space sharing strategies enabled the concept of virtual hardware, supporting the concurrent implementation of applications which would otherwise require far more

Manuel G. Gericota; Gustavo R. Alves; Miguel L. Silva; José M. Ferreira

151

A concurrent diagnosis of microbiological food safety output and food safety management system performance: Cases from meat processing industries  

Microsoft Academic Search

Stakeholder requirements force companies to analyse their food safety management system (FSMS) performance to improve food safety. Performance is commonly analysed by checking compliance against preset requirements via audits\\/inspections, or actual food safety (FS) output is analysed by microbiological testing. This paper discusses the usefulness of a concurrent diagnosis of FSMS performance and FS output using new tools; illustrated for

P. A. Luning; L. Jacxsens; J. Rovira; S. M. Osés; M. Uyttendaele; W. J. Marcelis

2011-01-01

152

Integrating Predicate Transition Nets with First Order Temporal Logic in the Specification and Verification of Concurrent Systems  

Microsoft Academic Search

This paper presents some results of integrating predicate transition nets with first order temporal logic in the specification and verification of concurrent systems. The intention of this research is to use predicate transition nets as a specification method and to use first order temporal logic as a verification method so that their strengths — the easy comprehension of predicate transition

Xudong He; John A. N. Lee

1990-01-01

153

Phase I Trial Using Patupilone (Epothilone B) and Concurrent Radiotherapy for Central Nervous System Malignancies  

SciTech Connect

Purpose: Based on preclinical data indicating the radiosensitizing potential of epothilone B, the present study was designed to evaluate the toxicity and response rate of patupilone, an epothilone B, with concurrent radiotherapy (RT) for the treatment of central nervous system malignancies. Methods and Materials: The present Phase I study evaluated the toxicities associated with patupilone combined with RT to establish the maximal tolerated dose. Eligible patients had recurrent gliomas (n = 10) primary (n = 5) or metastatic (n = 17) brain tumors. Dose escalation occurred if no dose-limiting toxicities, defined as any Grade 4-5 toxicity or Grade 3 toxicity requiring hospitalization, occurred during treatment. Results: Of 14 patients, 5 were treated with weekly patupilone at 1.5 mg/m{sup 2}, 4 at 2.0 mg/m{sup 2}, 4 at 2.5 mg/m{sup 2}, and 1 at 4 mg/m{sup 2}. Of 18 patients, 7 were treated in the 6-mg/m{sup 2} group, 6 in the 8-mg/m{sup 2} group, and 5 in the 10-mg/m{sup 2} group. Primary central nervous system malignancies received RT to a median dose of 60 Gy. Central nervous system metastases received whole brain RT to a median dose of 37.4 Gy, and patients with recurrent gliomas underwent stereotactic RT to a median dose of 37.5 Gy. One dose-limiting toxicity (pneumonia) was observed in group receiving 8-mg/m{sup 2} every 3 weeks. At the subsequent dose level (10 mg/m{sup 2}), two Grade 4 dose-limiting toxicities occurred (renal failure and pulmonary hemorrhage); thus, 8 mg/m{sup 2} every 3 weeks was the maximal tolerated dose and the recommended Phase II dose. Conclusion: Combined with a variety of radiation doses and fractionation schedules, concurrent patupilone was well tolerated and safe, with a maximal tolerated dose of 8 mg/m{sup 2} every 3 weeks.

Fogh, Shannon; Machtay, Mitchell; Werner-Wasik, Maria; Curran, Walter J.; Bonanni, Roseann [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA (United States); Axelrod, Rita [Department of Medical Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA (United States); Andrews, David [Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA (United States); Dicker, Adam P., E-mail: adam.dicker@jeffersonhospital.or [Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA (United States)

2010-07-15

154

Development of figurative language skills following central nervous system-directed chemotherapy delivered in early childhood.  

PubMed

Central nervous system (CNS)-directed chemotherapy is delivered for the treatment of childhood acute lymphoblastic leukaemia (ALL). Figurative language deficits have been described in children following CNS-directed chemotherapy; however, comprehensive analysis of figurative interpretation errors, potentially providing clinical utility to assist with intervention planning, has never been performed. The present study aimed to compare the figurative language skills of seven children treated with CNS-directed chemotherapy for ALL before the age of 6 years (mean age at diagnosis 3 years 10 months) and a matched control group of children, using the Test of Language Competence-Expanded Edition (TLC-E) Figurative Language sub-test. It was hypothesised that the children treated with CNS-directed chemotherapy would demonstrate a decreased performance in and an alternative method of interpreting figurative language. The results suggest no negative effects of CNS-directed chemotherapy on figurative language. There were no statistically significant differences between groups for TLC-E Figurative Language sub-test composite scores and picture component errors, nor were there clinically significant differences observed from descriptive comparisons of individual case data and error analysis. As these skills continue to emerge beyond childhood, the need to monitor skill development in ALL survivors beyond childhood is highlighted. PMID:23607904

Dowling, Emma K; Lewis, Fiona M; Murdoch, Bruce E

2014-04-01

155

Ophthalmic vasculature alterations following systemic chemotherapy and periocular Carboplatin treatment of advanced retinoblastoma.  

PubMed

The purpose of this study was to report significant alterations in orbital vasculature following combined systemic chemoreduction/laser ablation and periocular carboplatin treatment and to discuss treatment implications in two cases of advanced retinoblastoma. Assessment of orbital and ophthalmic vasculature was done following nine cycles of systemic chemotherapy. Intra-arterial chemotherapy was provided 6 months following completion of systemic chemoreduction, when the tumor was clearly active and progressive. Orbital angiography of both eyes, performed prior to the intra-arterial melphalan injection, documented sclerosis of the ophthalmic artery vasculature with delayed transit time, decreased choroidal blush, and anomalous vessels in the eye receiving periocular carboplatin injections. The orbital vasculature in the contralateral eye was not affected. Orbital and ophthalmic vascular alterations may occur with the use of combined systemic chemotherapy and periocular carboplatin. Systemic chemotherapy and focal transpupillary laser tumor ablation, alone, did not appear to impact the orbital and ophthalmic vascular supply. Impaired vascular supply may have significant influence on the impact of the efficacy of standard and future experimental therapeutic options. PMID:20886809

Piña, Yolanda; Boutrid, Hinda; Murray, Timothy G; Wolfe, Stacey Quintero; Schefler, Amy C; Houston, Samuel K; Moftakhar, Roham; Fernandes, Cristina E; Reichbach, Jennifer; Aziz, Hassan A; Markoe, Arnold M; Aziz-Sultan, Mohammad Ali

2010-01-01

156

Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma.  

PubMed

The majority of the available data on primary central nervous system lymphoma (PCNSL) derive from small unicentric or oligocentric studies. In this multicentre study, we evaluated the response, survival and toxicity in PCNSL patients after carmustine, methotrexate 1.5 g/m2, procarbazine and dexamethasone (BMPD) chemotherapy and searched for prognostic factors. Fifty-six patients received the BMPD protocol (dexamethasone was given only in course 1). The overall complete response rate to chemotherapy was 61% (34/56). Ten complete responders received whole-brain irradiation and 24 were not irradiated. Responders to chemotherapy had significantly longer median overall survival than non-responders (18.2 vs. 9.9 months, P = 0.02). Median survival was significantly longer at institutions accruing at least four patients than at those with fewer patients (31.5 vs. 9.5 months, P = 0.03). PMID:15638851

Korfel, Agnieszka; Martus, Peter; Nowrousian, Mohammad R; Hossfeld, Dieter K; Kirchen, Heinz; Brücher, Joachim; Stelljes, Matthias; Birkmann, Josef; Peschel, Christian; Pasold, Rita; Fischer, Lars; Jahnke, Kristoph; Thiel, Eckhard

2005-01-01

157

Multidisciplinary treatment including systemic chemotherapy for a malignant phyllodes tumour of the prostate  

PubMed Central

A 22-year-old man was referred to our hospital with macroscopic hematuria and consistent anal pain. Magnetic resonance imaging revealed an enlarged prostate tumour invading the bladder and rectum. A biopsy revealed an unclassified spindle cell sarcoma. Subsequently, radical cystoprostatectomy and resection of the rectum were performed. A histopathological examination revealed a prostatic malignant phyllodes tumour with a negative surgical margin. However, a local recurrence was identified 2 months after surgery. Induction therapy included 4 cycles of systemic chemotherapy comprising etoposide with ifosfamide and cisplatin. Although a partial response was observed at the local site, lung metastasis developed. Second-line chemotherapy with ifosfamide and doxorubicin with radiotherapy to the pelvis was administered and led to complete regression; however, its efficacy was transient. Although additional chemotherapy was administered, the patient eventually died due to the rapidly growing, recurrent tumour.

Murakami, Yasukiyo; Tabata, Ken-ichi; Sugita, Atsushi; Mochizuki, Kohei; Maeyama, Ryota; Okazaki, Miyoko; Nishi, Morihiro; Matsumoto, Kazumasa; Fujita, Tetsuo; Satoh, Takefumi; Jiang, Shi-Xu; Saegusa, Makoto; Iwamura, Masatsugu

2014-01-01

158

Long-term Follow-up of the RTOG 9501/Intergroup Phase III Trial: Postoperative Concurrent Radiation Therapy and Chemotherapy in High-Risk Squamous Cell Carcinoma of the Head and Neck  

SciTech Connect

Purpose: Previous analysis of this Intergroup trial demonstrated that with a median follow-up among surviving patients of 45.9 months, the concurrent postoperative administration of cisplatin and radiation therapy improved local-regional control and disease-free survival of patients who had high-risk resectable head-and-neck carcinomas. With a minimum of 10 years of follow-up potentially now available for all patients, these results are updated here to examine long-term outcomes. Methods and Materials: A total of 410 analyzable patients who had high-risk resected head-and-neck cancers were prospectively randomized to receive either radiation therapy (RT: 60 Gy in 6 weeks) or identical RT plus cisplatin, 100 mg/m{sup 2}i.v. on days 1, 22, and 43 (RT + CT). Results: At 10 years, the local-regional failure rates were 28.8% vs 22.3% (P=.10), disease-free survival was 19.1% vs 20.1% (P=.25), and overall survival was 27.0% vs 29.1% (P=.31) for patients treated by RT vs RT + CT, respectively. In the unplanned subset analysis limited to patients who had microscopically involved resection margins and/or extracapsular spread of disease, local-regional failure occurred in 33.1% vs 21.0% (P=.02), disease-free survival was 12.3% vs 18.4% (P=.05), and overall survival was 19.6% vs 27.1% (P=.07), respectively. Conclusion: At a median follow-up of 9.4 years for surviving patients, no significant differences in outcome were observed in the analysis of all randomized eligible patients. However, analysis of the subgroup of patients who had either microscopically involved resection margins and/or extracapsular spread of disease showed improved local-regional control and disease-free survival with concurrent administration of chemotherapy. The remaining subgroup of patients who were enrolled only because they had tumor in 2 or more lymph nodes did not benefit from the addition of CT to RT.

Cooper, Jay S., E-mail: jcooper@maimonidesmed.org [Maimonides Cancer Center, New York, New York (United States); Zhang Qiang; Pajak, Thomas F. [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States)] [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Forastiere, Arlene A. [Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland (United States)] [Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland (United States); Jacobs, John [Barbara Ann Karmanos Comprehensive Cancer Center, Wayne State University, Detroit, Michigan (United States)] [Barbara Ann Karmanos Comprehensive Cancer Center, Wayne State University, Detroit, Michigan (United States); Saxman, Scott B. [Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland (United States)] [Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland (United States); Kish, Julie A. [H. Lee Moffitt Cancer Center, Tampa, Florida (United States)] [H. Lee Moffitt Cancer Center, Tampa, Florida (United States); Kim, Harold E. [Wayne State University Medical Center, Detroit, Michigan (United States)] [Wayne State University Medical Center, Detroit, Michigan (United States); Cmelak, Anthony J. [Vanderbilt Cancer Center, Nashville, Tennessee (United States)] [Vanderbilt Cancer Center, Nashville, Tennessee (United States); Rotman, Marvin [SUNY Health Center at Brooklyn, Brooklyn, New York (United States)] [SUNY Health Center at Brooklyn, Brooklyn, New York (United States); Lustig, Robert [Hospital of University of Pennsylvania, Philadelphia, Pennsylvania (United States)] [Hospital of University of Pennsylvania, Philadelphia, Pennsylvania (United States); Ensley, John F. [Barbara Ann Karmanos Comprehensive Cancer Center, Wayne State University, Detroit, Michigan (United States)] [Barbara Ann Karmanos Comprehensive Cancer Center, Wayne State University, Detroit, Michigan (United States); Thorstad, Wade [Washington University, St. Louis, Missouri (United States)] [Washington University, St. Louis, Missouri (United States); Schultz, Christopher J. [Medical College of Wisconsin, Milwaukee, Wisconsin (United States)] [Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Yom, Sue S. [University of California, San Francisco, California (United States)] [University of California, San Francisco, California (United States); Ang, K. Kian [University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-12-01

159

Long-Term Follow-Up of the RTOG 9501/Intergroup Phase III Trial: Postoperative Concurrent Radiation Therapy and Chemotherapy in High-Risk Squamous Cell Carcinoma of the Head & Neck  

PubMed Central

Purpose Previous analysis of this Intergroup trial demonstrated that with a median follow-up among surviving patients of 45.9 months, the concurrent postoperative administration of cisplatin and radiation therapy improved local-regional control and disease-free survival of patients who had high-risk resectable head and neck carcinomas. With a minimum of 10 years of follow-up potentially now available for all patients, these results are herein updated to examine long-term outcomes. Methods and Materials 410 analyzable patients who had high-risk resected head and neck cancers were prospectively randomized to receive either radiation therapy (RT: 60 Gy in 6 weeks) or identical RT plus cisplatin, 100 mg/m2 i.v. on days 1, 22, and 43 (RT + CT). Results At 10 years, the local-regional failure rates were 28.8% vs. 22.3% (p=0.10), disease-free survival was 19.1% vs. 20.1% (p=0.25) and overall survival was 27.0% vs. 29.1% (p=0.31) for patients treated by RT vs. RT + CT respectively. In the unplanned subset analysis limited to patients who had microscopically involved resection margins and/or extracapsular spread of disease, local-regional failure occurred in 33.1% vs. 21.0% (p=0.02), disease-free survival was 12.3% vs. 18.4% (p=0.05) and overall survival was 19.6% vs. 27.1% (p=0.07) respectively. Conclusion At a median follow-up of 9.4 years for surviving patients no significant differences in outcome were observed in the analysis of all randomized eligible patients. However, analysis of the subgroup of patients who had either microscopically involved resection margins and/or extracapsular spread of disease showed improved local-regional control and disease-free survival with concurrent administration of chemotherapy. The remaining subgroup of patients who were enrolled only because they had tumor in 2 or more lymph nodes did not benefit from the addition of CT to RT.

Cooper, Jay S.; Zhang, Qiang; Pajak, Thomas F.; Forastiere, Arlene A.; Jacobs, John; Saxman, Scott B.; Kish, Julie A.; Kim, Harold E.; Cmelak, Anthony J.; Rotman, Marvin; Lustig, Robert; Ensley, John F.; Thorstad, Wade; Schultz, Christopher J.; Yom, Sue S.; Ang, K. Kian

2012-01-01

160

Partial response after transcatheter arterial infusion chemotherapy in a patient with systemic chemotherapy-resistant unresectable colon cancer and hepatic metastasis: (case report).  

PubMed

We report here a case of partial response to hepatic arterial infusion chemotherapy in a patient who developed serious hepatic failure due to unresectable colorectal cancer and hepatic metastasis and showed resistance to systemic chemotherapy with molecular targeted drugs, mFOLFOX6, and FOLFIRI. The patient was a 60-year-old woman who underwent sigmoidectomy for sigmoid colon cancer, lateral posterior hepatic segmentectomy for metastatic liver cancer, and postoperative radiation therapy for metastatic lung cancer. As first-line systemic chemotherapy, mFOLFOX6 (oxaliplatin, 5-fluorouracil, and leucovorin), bevacizumab?+?FOLFIRI (irinotecan, 5-fluorouracil, leucovorin), and anti-epidermal growth factor receptor antibody ?+ irinotecan were administered, in that order. However, recurrent hepatic metastasis was exacerbated, which induced serious hepatic failure manifested by general malaise, jaundice, abnormal hepatic function, difficulty in walking due to bilateral lower extremity edema, and decreased appetite. The patient was admitted in a serious condition. After hospitalization, the patient received hepatic arterial infusion chemotherapy with 5-fluorouracil and l-leucovorin. After two complete courses, the symptoms improved. The patient's performance status also improved, and she was discharged from the hospital. Four months after discharge, the patient had continued outpatient chemotherapy and maintained excellent performance status. Although HAIC is not presently considered an alternative to systemic chemotherapy, it is sometimes effective in patients who show resistance to molecular targeted drug therapy, FOLFOX, and FOLFIRI, and in whom hepatic metastasis is a key factor in determining prognosis and serious hepatic failure. Further studies should be performed in the future to verify these findings. PMID:23957924

Sawai, Katsuji; Goi, Takanori; Koneri, Kenji; Katayama, Kanji; Yamaguchi, Akio

2013-01-01

161

A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer  

PubMed Central

Abstract Manganese superoxide dismutase (MnSOD) is a genetically engineered therapeutic DNA/liposome containing the human MnSOD transgene. Preclinical studies in mouse models have demonstrated that the expression of the human MnSOD transgene confers protection of normal tissues from ionizing irradiation damage. This is a phase I study of MnSOD plasmid liposome (PL) in combination with standard chemoradiation in surgically unresectable stage III non-small-cell lung cancer. Chemotherapy (carboplatin and paclitaxel) was given weekly (for 7 weeks), concurrently with radiation. MnSOD PL was swallowed twice a week (total 14 doses), at three dose levels: 0.3, 3, and 30?mg. Dose escalation followed a standard phase I design. Esophagoscopy was done at baseline, day 4, and 6 weeks after radiation with biopsies of the squamous lining cells. DNA was extracted and analyzed by PCR for the detection of the MnSOD transgene DNA. Ten patients with AJCC stage IIIA (three) and IIIB (seven) completed the course of therapy. Five had squamous histology, two adenocarcinoma, one large cell, and two not specified. Patients were treated in three cohorts at three dose levels of MnSOD PL: 0.3 (three patients), 3 (three patients), and 30?mg (four patients). The median dose of radiation was 77.7?Gy (range 63–79.10?Gy). Overall response rate for the standard chemoradiation regimen was 70% (n?=?10). There were no dose-limiting toxicities reported in all three dosing tiers. It is concluded that the oral administration of MnSOD PL is feasible and safe. The phase II recommended dose is 30?mg.

Belani, Chandra P.; Luketich, James D.; Argiris, Athanassios; Ramalingam, Suresh S.; Gooding, William; Pennathur, Arjun; Petro, Daniel; Kane, Kevin; Liggitt, Denny; ChampionSmith, Tony; Zhang, Xichen; Epperly, Michael W.

2011-01-01

162

Blood Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients with Colorectal Liver Metastases Treated with Systemic Chemotherapy  

Microsoft Academic Search

Background  Whether neutrophil-to-lymphocyte ratio (NLR) predicts survival of patients with colorectal liver metastases (CLM) treated\\u000a with systemic chemotherapy remains unclear.\\u000a \\u000a \\u000a \\u000a Methods  Clinicopathologic data were reviewed for patients with CLM treated with chemotherapy and resection (n = 200) or chemotherapy only (n = 90). Univariate and multivariate analyses for prognostic factors were performed. In the resection group, whether chemotherapy\\u000a normalizes high NLR and the effect of NLR

Yoji Kishi; Scott Kopetz; Yun Shin Chun; Martin Palavecino; Eddie K. Abdalla; Jean-Nicolas Vauthey

2009-01-01

163

Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer  

Microsoft Academic Search

BACKGROUND: Drug resistance in breast cancer is a major obstacle to successful chemotherapy. In this study we used cDNA microarray technology to examine gene expression profiles obtained from fine needle aspiration (FNA) of primary breast tumors before and after systemic chemotherapy. Our goal was to determine the feasibility of obtaining representative expression array profiles from limited amounts of tissue and

Christos Sotiriou; Trevor J Powles; Mitch Dowsett; Amir A Jazaeri; Andrew L Feldman; Laura Assersohn; Chandramouli Gadisetti; Steven K Libutti; Edison T Liu

2002-01-01

164

Concurrent-scene/alternate-pattern analysis for robust video-based docking systems  

NASA Technical Reports Server (NTRS)

A typical docking target employs a three-point design of retroreflective tape, one at each endpoint of the center-line, and one on the tip of the central post. Scenes, sensed via laser diode illumination, produce pictures with spots corresponding to desired reflection from the retroreflectors and other reflections. Control corrections for each axis of the vehicle can then be properly applied if the desired spots are accurately tracked. However, initial acquisition of these three spots (detection and identification problem) are non-trivial under a severe noise environment. Signal-to-noise enhancement, accomplished by subtracting the non-illuminated scene from the target scene illuminated by laser diodes, can not eliminate every false spot. Hence, minimization of docking failures due to target mistracking would suggest needed inclusion of added processing features pertaining to target locations. In this paper, we present a concurrent processing scheme for a modified docking target scene which could lead to a perfect docking system. Since the non-illuminated target scene is already available, adding another feature to the three-point design by marking two non-reflective lines, one between the two end-points and one from the tip of the central post to the center-line, would allow this line feature to be picked-up only when capturing the background scene (sensor data without laser illumination). Therefore, instead of performing the image subtraction to generate a picture with a high signal-to-noise ratio, a processed line-image based on the robust line detection technique (Hough transform) can be used to fuse with the actively sensed three-point target image to deduce the true locations of the docking target. This dual-channel confirmation scheme is necessary if a fail-safe system is to be realized from both the sensing and processing point-of-views. Detailed algorithms and preliminary results are presented.

Udomkesmalee, Suraphol

1991-01-01

165

Unresectable Locally Advanced Pancreatic Cancer: Concurrent Chemotherapy  

Microsoft Academic Search

Pancreatic cancer (PC) is one of the most troublesome solid tumors, and remains a major challenge to oncologists. Approximately\\u000a 40% of patients with PC present with locally advanced disease, and generally the treatment of this situation is not curative.\\u000a Locally advanced PC (LAPC) is commonly defined as the tumor invading the celiac axis, superior mesenteric artery, inferior\\u000a vena cava, aorta,

Ender Kurt; Meral Kurt; Turkkan Evrensel; Lutfi Ozkan; Osman Manavoglu

166

The TRIDEC System-of-Systems; Choreography of large-scale concurrent tasks in Natural Crisis Management  

NASA Astrophysics Data System (ADS)

The project Collaborative, Complex, and Critical Decision-Support in Evolving Crises (TRIDEC), co-funded by the European Commission in its Seventh Framework Programme aims at establishing a network of dedicated, autonomous legacy systems for large-scale concurrent management of natural crises utilising heterogeneous information resources. TRIDEC's architecture reflects the System-of- Systems (SoS) approach which is based on task-oriented systems, cooperatively interacting as a collective in a common environment. The design of the TRIDEC-SoS follows the principles of service-oriented and event-driven architectures (SOA & EDA) exceedingly focusing on a loose coupling of the systems. The SoS approach in combination with SOA and EDA has the distinction of being able to provide novel and coherent behaviours and features resulting from a process of dynamic self-organisation. Self-organisation is a process without the need for a central or external coordinator controlling it through orchestration. It is the result of enacted concurrent tasks in a collaborative environment of geographically distributed systems. Although the individual systems act completely autonomously, their interactions expose emergent structures of evolving nature. Particularly, the fact is important that SoS are inherently able to evolve on all facets of intelligent information management. This includes adaptive properties, e.g. seamless integration of new resource types or the adoption of new fields in natural crisis management. In the case of TRIDEC with various heterogeneous participants involved, concurrent information processing is of fundamental importance because of the achievable improvements regarding cooperative decision making. Collaboration within TRIDEC will be implemented with choreographies and conversations. Choreographies specify the expected behaviour between two or more participants; conversations describe the message exchange between all participants emphasising their logical relation. The TRIDEC choreography will be based on the definition of Behavioural Interfaces and Service Level Agreements, which describe the interactions of all participants involved in the collaborative process by binding the tasks of dedicated systems to high-level business processes. All methods of a Behavioural Interfaces can be assigned dynamically to the activities of a business process. This allows it to utilise a system during the run-time of a business process and thus, for example enabling task balancing or the delegation of responsibilities. Since the individual parts of a SoS are normally managed independently and operate autonomously because of their geographical distribution it is of vital importance to ensure the reliability (robustness and correctness) of their interactions which will be achieved by applying the Design by Contract (DbC) approach to the TRIDEC architecture. Key challenge for TRIDEC is establishing a reliable adaptive system which exposes an emergent behaviour, for example intelligent monitoring strategies or dynamic system adaptions even in case of partly system failures. It is essential for TRIDEC that for example redundant parts of the system can take over tasks from defect components in a process of re-organising its network.

Häner, R.; Wächter, J.

2012-04-01

167

A web-based advisory system for process and material selection in concurrent product design for a manufacturing environment  

Microsoft Academic Search

This paper reports the work of selecting suitable manufacturing processes and materials in concurrent design for manufacturing environment. In the paper, a fuzzy knowledge-based decision support method is proposed for multi-criteria decision-making in evaluating and selecting possible manufacturing process\\/material combinations in terms of the total production cost. Based on the proposed method, a prototype Web-based knowledge-intensive manufacturing consulting service system

Xuan F. Zha

2005-01-01

168

Request Order Linked List (ROLL): A Concurrency Control Object for Centralized and Distributed Database Systems  

Microsoft Academic Search

A database concurrency control object called ROLL (request order linked list), which is a linked list of bit vectors, is introduced together with three simple operations available to transactions: POST, CHECK and RELEASE. POST is used to establish serialization order. CHECK is used to determine current resource availability. RELEASE is used to relinquish resources. ROLL is based on the serialization

William Perrizo; Fargo ND

1991-01-01

169

An Object Versioning System to Support Collaborative Design within a Concurrent Engineering Context  

Microsoft Academic Search

Engineering design is a collaborative and evolutionary process, involving designers from many disciplines. It is traditionally performed as a series of consecutive tasks, with any failures causing control to be passed back to the preceding task. If some or all of the design phases are able to be executed concurrently instead of sequentially, major improvements can be achieved. This approach

I. Santoyridis; Tom W. Carnduff; W. A. Gray; John C. Miles

1997-01-01

170

Benchmarking an interdisciplinary concurrent design methodology for electronic\\/mechanical systems  

Microsoft Academic Search

The paper describes the evolution of an Interdisciplinary Concurrent Design Methodology (ICDM) and the metrics used to compare four generations of wearable computer artifacts produced by the methodology at each stage of ICDM's growth. The product cycle is defined, its phases, and the design informa- tion representation for each phase. Six generic axes of design activity are defined, and the

Asim Smailagic; Daniel P. Siewiorek; Drew Anderson; Chris Kasaback; Thomas L. Martin; John Stivoric

1995-01-01

171

Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy.  

PubMed

We have previously reported that a burst of vascular endothelial growth factor (VEGF) signaling to tumor-associated endothelium induces a proviral state, during which systemically delivered oncolytic reovirus can replicate in endothelium, thereby inducing immune-mediated vascular collapse and significant antitumor therapy. Using chimeric receptors, we show here that induction of the proviral state proceeds through VEGFR2, but not VEGFR1, signaling in endothelial cells. In contrast, innate immune activation by reovirus-exposed endothelial cells was predominantly through VEGFR1. By screening conventional chemotherapies for their ability to induce similar effects in combination with reovirus both in vitro and in vivo, we observed that the proviral state could also be induced in endothelial cells exposed to VEGF during rebound from paclitaxel-mediated inhibition of VEGF signaling. We translated these in vitro findings in vivo by careful scheduling of paclitaxel chemotherapy with systemic virotherapy, neither of which alone had therapeutic effects against B16 tumors. Systemic availability of reovirus during endothelial cell recovery from paclitaxel treatment allowed for endothelial replication of the virus, immune-mediated therapy, and tumor cures. Therefore, careful scheduling of combination viro- and chemotherapies, which preclinical testing suggests are individually ineffective against tumor cells, can lead to rational new clinical protocols for systemic treatments with oncolytic viruses. PMID:21792179

Kottke, Timothy; Chester, John; Ilett, Elizabeth; Thompson, Jill; Diaz, Rosa; Coffey, Matt; Selby, Peter; Nuovo, Gerard; Pulido, Jose; Mukhopadhyay, Debabrata; Pandha, Hardev; Harrington, Kevin; Melcher, Alan; Vile, Richard

2011-10-01

172

Advances and directions in chemotherapy using implantable port systems for colorectal cancer: a historical review.  

PubMed

With the recent advances in chemotherapy for colorectal cancer, the prognosis for patients with metastatic colorectal cancer has been significantly improved. The development of the implantable port system has also enabled patients to receive multiagent chemotherapy with a more satisfactory quality of life. Historically, chemotherapy using implantable port systems was begun to obtain an oncological benefit in the treatment of locoregional cancer. In the 1950s, there was an increasing interest in perfusion techniques for the application of chemotherapeutic agents, such as nitrogen mustard, in the locoregional treatment of metastatic cancer. Among them, the treatment of liver metastasis has interested oncologists for many years. On the other hand, implantable devices were developed during the intervening decades that have enabled patients with colorectal cancer with liver metastases to be treated effectively using hepatic arterial infusion; which became more common in the 1980s. The treatment of metastatic colorectal cancer increasingly requires a multimodal approach and multiple treatment options based not on convenience, but in terms of personalization and efficacy. Therefore, it is important to optimize the pharmacokinetics of chemotherapeutic agents. Implantable port systems for colorectal cancer patients have been essential for oncological practice, and the importance of these systems will remain unchanged in the near future. PMID:23893159

Inoue, Yasuhiro; Kusunoki, Masato

2014-08-01

173

Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study  

PubMed Central

The objective was to evaluate response rate, response duration, and toxicity after systemic and intraventricular chemotherapy in primary CNS lymphoma (PCNSL).? From September 1995 to September 1998, 20 consecutive patients with PCNSL (median age 64, range 27 to 71 years) were enrolled in a pilot study evaluating chemotherapy without radiotherapy. A high dose methotrexate (MTX) (cycles 1, 2, 4, 5) and cytarabine (ara-C) (cycles 3, 6) based systemic therapy (including dexamethasone, vinca alkaloids, ifosfamide, and cyclophosphamide) was combined with intraventricular MTX, prednisolone, and ara-C.? Complete response was achieved in 11 and partial remission in two patients; in one response could not be determined. Four patients showed progressive disease and two (70, 71 years) died from treatment related complications. Observation time was 2 to 59 months (median 31.5 months). Kaplan-Meier estimate for median time to treatment failure (TTF) was 20.5 months, and for median survival 54 months. Systemic toxicity was mainly hematological. Ommaya reservoir infection occurred in four patients and acute transient MTX induced encephalopathy in two (subacute in another). Cognitive dysfunction possibly due to treatment was seen in only one patient after relapse and after a total of 12 cycles (six at relapse).? In conclusion, primary chemotherapy based on high dose MTX and ara-C is highly efficient in PCNSL. Toxicity is manageable in patients younger than 70years.??

Schlegel, U; Pels, H; Glasmacher, A; Kleinschmidt, R; Schmidt-Wolf, I; Helmstaedter, C; Fliessbach, K; Deckert, M; Van Roost, D; Fimmers, R; Bode, U; Klockgether, T

2001-01-01

174

Dynamic programming methods for concurrent design and dynamic allocation of vehicles embedded in a system-of-systems  

NASA Astrophysics Data System (ADS)

Recent developments indicate a changing perspective on how systems or vehicles should be designed. Such transition comes from the way decision makers in defense related agencies address complex problems. Complex problems are now often posed in terms of the capabilities desired, rather than in terms of requirements for a single systems. As a result, the way to provide a set of capabilities is through a collection of several individual, independent systems. This collection of individual independent systems is often referred to as a "System of Systems'' (SoS). Because of the independent nature of the constituent systems in an SoS, approaches to design an SoS, and more specifically, approaches to design a new system as a member of an SoS, will likely be different than the traditional design approaches for complex, monolithic (meaning the constituent parts have no ability for independent operation) systems. Because a system of system evolves over time, this simultaneous system design and resource allocation problem should be investigated in a dynamic context. Such dynamic optimization problems are similar to conventional control problems. However, this research considers problems which not only seek optimizing policies but also seek the proper system or vehicle to operate under these policies. This thesis presents a framework and a set of analytical tools to solve a class of SoS problems that involves the simultaneous design of a new system and allocation of the new system along with existing systems. Such a class of problems belongs to the problems of concurrent design and control of a new systems with solutions consisting of both optimal system design and optimal control strategy. Rigorous mathematical arguments show that the proposed framework solves the concurrent design and control problems. Many results exist for dynamic optimization problems of linear systems. In contrary, results on optimal nonlinear dynamic optimization problems are rare. The proposed framework is equipped with the set of analytical tools to solve several cases of nonlinear optimal control problems: continuous- and discrete-time nonlinear problems with applications on both optimal regulation and tracking. These tools are useful when mathematical descriptions of dynamic systems are available. In the absence of such a mathematical model, it is often necessary to derive a solution based on computer simulation. For this case, a set of parameterized decision may constitute a solution. This thesis presents a method to adjust these parameters based on the principle of stochastic approximation simultaneous perturbation using continuous measurements. The set of tools developed here mostly employs the methods of exact dynamic programming. However, due to the complexity of SoS problems, this research also develops suboptimal solution approaches, collectively recognized as approximate dynamic programming solutions, for large scale problems. The thesis presents, explores, and solves problems from an airline industry, in which a new aircraft is to be designed and allocated along with an existing fleet of aircraft. Because the life cycle of an aircraft is on the order of 10 to 20 years, this problem is to be addressed dynamically so that the new aircraft design is the best design for the fleet over a given time horizon.

Nusawardhana

175

Self-healing components in robust software architecture for concurrent and distributed systems  

Microsoft Academic Search

This paper describes an approach to designing self-healing components for robust, concurrent and distributed software architecture. A self-healing component is able to detect object anomalies inside of the component, reconfigure inter-component and intra-components before and after repairing the sick object, repair it, and then test the healed object. For this, each self-healing component is structured to the layered architecture with

Michael E. Shin

2005-01-01

176

Concurrency, latency, or system overhead: which has the largest impact on uniprocessor DRAM-system performance?  

Microsoft Academic Search

Given a fixed CPU architecture and a fixed DRAM timing specifica- tion, there is still a large design space for a DRAM system organiza- tion. Parameters include the number of memory channels, the bandwidth of each channel, burst sizes, queue sizes and organiza- tions, turnaround overhead, memory-controller page protocol, algo- rithms for assigning request priorities and scheduling requests dynamically, etc.

Vinodh Cuppu; Bruce L. Jacob

2001-01-01

177

Online chemotherapy symptom care and patient management system: an evaluative study.  

PubMed

Health delivery practices are shifting toward home care, because of better possibilities for managing chronic care, controlling health delivery costs, and increasing the quality of life and quality of health services, and the distinct possibility of predicting and thus avoiding serious complications. The study aimed to explore the benefits of an online Symptom Care and Management System in the home for patients receiving chemotherapy. A single-group experimental design was used. Thirty patients aged between 37 and 77 years undergoing their first or commencing a new course of chemotherapy treatment were recruited from November 2010 and December 2012 at a cancer center in Singapore. All patients used the Symptom Care and Management System to send daily symptom reports to the cancer center and received symptom management advice from the oncology nurse via teleconferencing during the first four chemotherapy treatment cycles. Patients' perceptions of the use of the Symptom Care and Management System were evaluated. All participants perceived the Symptom Care and Management System as a user-friendly interface and believed that they felt more involved in their care, and the system made it easier to understand some of the problems they experienced and helped them manage the symptoms more easily during the treatment. In addition, 29 participants (96.7%) felt that the nurse could contact them better via the Symptom Care and Management System, the Symptom Care and Management System helped them explain their symptoms to the nurse, and that it was simple to understand. The results presented in this study suggested that the Symptom Care and Management System has the potential to enhance remote monitoring and provides a feasible and acceptable way for a specific group of cancer patients to manage their symptoms at home. PMID:24378370

Chan, Moon Fai; Ang, Neo Kim Emily; Cho, Aye Aye; Chow, Ying Leng; Taylor, Beverly

2014-02-01

178

[A case of AFP-producing gastric cancer responding to the combination of systemic chemotherapy, transcatheter arterial embolization and hepatic infusion chemotherapy].  

PubMed

We report a case of a 64-year-old male with a-fetoprotein(AFP)-producing gastric cancer accompanied by large liver metastases and multiple lymph node metastases. The patient's serum AFP level was 42,307 ng/mL and a biopsy specimen showed AFP-positive tumor cells immunohistochemically. Systemic chemotherapy by tegafur gimeracil oteracil potassium(S-1)and local therapy for the hepatic metastases consisting of transcatheter arterial embolization (TAE)and infusion of epirubicin(EPI)to the hepatic arteries decreased the serum AFP level and reduced the gastric cancer and metastases. Due to the increase of AFP and lymph node metastases, we had to successively change the regimen to paclitaxel(PTX), a combination of cisplatin(CDDP)/irinotecan(CPT-11)and S-1. Continuous systemic chemotherapy in combination with various drugs for gastric cancer treatment followed by TAE and hepatic infusion chemotherapy for hepatic metastases proved effective. The patient survived for 3 years and 2 months. PMID:19461191

Shiochi, Hideki; Yamada, Minoru; Kishina, Manabu; Murawaki, Yoshiyuki; Miura, Masahiko; Azumi, Takane; Yuuki, Takafumi; Tanaka, Shinsuke; Kono, Michimori; Yoshimura, Teiji; Yoshida, Manabu; Shabana, Masanobu

2009-05-01

179

The Concurrency Column  

Microsoft Academic Search

Process calculi like ACP, CCS, CSP and various flavours of the ?-calculus are popular specification formalisms for concurrent, distribu ted and possibly mo- bile systems. The semantic theory of process calculi has been the subject of extensive investigation for about twenty five years now, and several robust, general principles and results applying to a variety of different formalisms have been

Luca Aceto

180

Sensors 2000! Program: Advanced Biosensor and Measurement Systems Technologies for Spaceflight Research and Concurrent, Earth-Based Applications  

NASA Technical Reports Server (NTRS)

Sensors 2000! (S2K!) is a specialized, integrated projects team organized to provide focused, directed, advanced biosensor and bioinstrumentation systems technology support to NASA's spaceflight and ground-based research and development programs. Specific technology thrusts include telemetry-based sensor systems, chemical/ biological sensors, medical and physiological sensors, miniaturized instrumentation architectures, and data and signal processing systems. A concurrent objective is to promote the mutual use, application, and transition of developed technology by collaborating in academic-commercial-govemment leveraging, joint research, technology utilization and commercialization, and strategic partnering alliances. Sensors 2000! is organized around three primary program elements: Technology and Product Development, Technology infusion and Applications, and Collaborative Activities. Technology and Product Development involves development and demonstration of biosensor and biotelemetry systems for application to NASA Space Life Sciences Programs; production of fully certified spaceflight hardware and payload elements; and sensor/measurement systems development for NASA research and development activities. Technology Infusion and Applications provides technology and program agent support to identify available and applicable technologies from multiple sources for insertion into NASA's strategic enterprises and initiatives. Collaborative Activities involve leveraging of NASA technologies with those of other government agencies, academia, and industry to concurrently provide technology solutions and products of mutual benefit to participating members.

Hines, J.

1999-01-01

181

Sensing materials with a concurrent sensitivity: design, synthesis and application in multisensory systems  

NASA Astrophysics Data System (ADS)

A series of novel sensing materials with concurrent sensitivity, namely the porphyrins [free-base, Mn(III) and Fe(III) complexes], functionalized with crown-ether or aza-crown (cyclam) pendant groups, were synthesized and tested as ionophores for polymeric membrane electrodes. Several aspects were studied in order to evaluate the functionality and the desired sensitivity of resulting crown-porphyrins hyphenated ionophores, among them the nature and the size of crown fragment cavity, the length of the alkyl pendant incorporating the crown-ether unit, the presence and the nature of central metal ion both in porphyrin and crown macrocycles.

Lvova, Larisa; Pomarico, Giuseppe; Spiridonov, Igor; Mednova, Olga; Kirsanov, Dmitry; Legin, Andrey; di Natale, Corrado; D'Amico, Arnaldo; Paolesse, Roberto

2011-09-01

182

High-dose chemotherapy with hematopoietic stem cell transplantation for the treatment of primary central nervous system lymphoma  

Microsoft Academic Search

Primary central nervous system lymphoma (PCNSL) is a rare B-cell lymphoid neoplasm for which current regimens utilizing standard-dose\\u000a chemotherapy and\\/or radiation therapy lead to high relapse rates and\\/or unacceptable neurologic sequelae. High-dose chemotherapy\\u000a followed by hematopoietic stem cell transplantation may overcome limitations of current treatment schemas. A search was performed\\u000a of all English-language literature (1968 to June 2009) within the

Christopher J. Campen; Rebecca L. Tombleson; Myke R. Green

2011-01-01

183

On Optimistic Methods for Concurrency Control  

Microsoft Academic Search

Most current approaches to concurrency control in database systems rely on locking of data objects as a control mechanism. In this paper, two families of nonlocking concurrency controls are presented. The methods used are \\

H. T. Kung; John T. Robinson

1979-01-01

184

Optimistic Concurrency Control for Distributed Databases.  

National Technical Information Service (NTIS)

One of the most important considerations in developing a distributed data-base system is the concurrency control mechanism. Recently, many arguments have been advanced in favor of the optimistic solution to concurrency control. This work reviews two algor...

W. P. McElyea

1982-01-01

185

CURARE. Restructuring Lisp Programs for Concurrent Execution.  

National Technical Information Service (NTIS)

This paper describes the techniques used by CURARE, a program transformer, to restructure Lisp programs for concurrent execution in shared-memory multi-processor Lisp systems. CURARE tries to eliminate control and data-dependencies that prevent concurrent...

J. R. Larus

1987-01-01

186

Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy on Systemic Toxicity  

Microsoft Academic Search

Introduction  The purpose of this study was to analyze the postoperative systemic toxicity and procedure-related mortality (PRM) of cytoreductive\\u000a surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal surface malignancies (PSMs).\\u000a \\u000a \\u000a \\u000a Patients and methods  A total of 242 (84 males\\/158 females) patients with PSM underwent 247 consecutive procedures. The mean age was 52 years (range\\u000a 22–79). CRS was performed

Shigeki Kusamura; Dario Baratti; Rami Younan; Barbara Laterza; Grazia Daniela Oliva; Pasqualina Costanzo; Myriam Favaro; Cecilia Gavazzi; Federica Grosso; Marcello Deraco

2007-01-01

187

Concurrent Quantification of Proteome and Phosphoproteome to Reveal System-wide Association of Protein Phosphorylation and Gene Expression*  

PubMed Central

Reversible phosphorylation of proteins is an important process modulating cellular activities from upstream, which mainly involves sequential phosphorylation of signaling molecules, to downstream where phosphorylation of transcription factors regulates gene expression. In this study, we combined quantitative labeling with multidimensional liquid chromatography-mass spectrometry to monitor the proteome and phosphoproteome changes in the initial period of adipocyte differentiation. The phosphorylation level of a specific protein may be regulated by a kinase or phosphatase without involvement of gene expression or as a phenomenon that accompanies the alteration of its gene expression. Concurrent quantification of phosphopeptides and non-phosphorylated peptides makes it possible to differentiate cellular phosphorylation changes at these two levels. Furthermore, on the system level, certain proteins were predicted as the targeted gene products regulated by identified transcription factors. Among them, several proteins showed significant expression changes along with the phosphorylation alteration of their transcription factors. This is to date the first work to concurrently quantify proteome and phosphoproteome changes during the initial period of adipocyte differentiation, providing an approach to reveal the system-wide association of protein phosphorylation and gene expression.

Wu, Yi-Bo; Dai, Jie; Yang, Xing-Lin; Li, Su-Jun; Zhao, Shi-Lin; Sheng, Quan-Hu; Tang, Jia-Shu; Zheng, Guang-Yong; Li, Yi-Xue; Wu, Jia-Rui; Zeng, Rong

2009-01-01

188

Treatment of a primary intracranial germ cell tumor with systemic chemotherapy  

SciTech Connect

Primary germ cell neoplasms of the central nervous system (CNS) are rare tumors which generally respond to radiotherapy. Experience is limited in managing the refractory patient. We report a patient whose suprasellar dysgerminoma responded completely to 5,000 rad. Seven years later, disease recurrence was refractory to an additional 4,000 rad. Theorizing that the ''blood-brain barrier'' was no longer intact after extensive radiotherapy and tumor involvement of the ventricular system, the patient was treated with systemic bleomycin, cisplatin, and vinblastine. Pharmacokinetic studies revealed that the bleomycin and cisplatin entered the cerebrospinal fluid. Serial CT scans and CSF levels of beta-HCG confirmed the clinical impression of a partial remission. Subsequent tumor progression was refractory to therapy with intraventricular bleomycin. It is concluded that systemic chemotherapy may be beneficial in certain cases of CNS germ cell neoplasms.

Kirshner, J.J.; Ginsberg, S.J.; Fitzpatrick, A.V.; Comis, R.L.

1981-01-01

189

Radiation Therapy Oncology Group Protocol 02-29: A Phase II Trial of Neoadjuvant Therapy With Concurrent Chemotherapy and Full-Dose Radiation Therapy Followed by Surgical Resection and Consolidative Therapy for Locally Advanced Non-small Cell Carcinoma of the Lung  

SciTech Connect

Purpose: To evaluate mediastinal nodal clearance (MNC) rates after induction chemotherapy and concurrent, full-dose radiation therapy (RT) in a phase II trimodality trial (Radiation Therapy Oncology Group protocol 0229). Patients and Methods: Patients (n=57) with stage III non-small cell lung cancer (pathologically proven N2 or N3) were eligible. Induction chemotherapy consisted of weekly carboplatin (AUC = 2.0) and paclitaxel 50 mg/m{sup 2}. Concurrent RT was prescribed, with 50.4 Gy to the mediastinum and primary tumor and a boost of 10.8 Gy to all gross disease. The mediastinum was pathologically reassessed after completion of chemoradiation. The primary endpoint of the study was MNC, with secondary endpoints of 2-year overall survival and postoperative morbidity/mortality. Results: The grade 3/4 toxicities included hematologic 35%, gastrointestinal 14%, and pulmonary 23%. Forty-three patients (75%) were evaluable for the primary endpoint. Twenty-seven patients achieved the primary endpoint of MNC (63%). Thirty-seven patients underwent resection. There was a 14% incidence of grade 3 postoperative pulmonary complications and 1 30-day, postoperative grade 5 toxicity (3%). With a median follow-up of 24 months for all patients, the 2-year overall survival rate was 54%, and the 2-year progression-free survival rate was 33%. The 2-year overall survival rate was 75% for those who achieved nodal clearance, 52% for those with residual nodal disease, and 23% for those who were not evaluable for the primary endpoint (P=.0002). Conclusions: This multi-institutional trial confirms the ability of neoadjuvant concurrent chemoradiation with full-dose RT to sterilize known mediastinal nodal disease.

Suntharalingam, Mohan, E-mail: msuntha@umm.edu [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States)] [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States); Paulus, Rebecca [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States)] [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Edelman, Martin J. [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States)] [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States); Krasna, Mark [Cancer Center at St. Joseph Medical Center, Towson, Maryland (United States)] [Cancer Center at St. Joseph Medical Center, Towson, Maryland (United States); Burrows, Whitney [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States)] [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland (United States); Gore, Elizabeth [Dept of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States)] [Dept of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin (United States); Wilson, Lynn D. [Dept of Radiation Oncology, Yale School of Medicine, New Haven, Connecticut (United States)] [Dept of Radiation Oncology, Yale School of Medicine, New Haven, Connecticut (United States); Choy, Hak [Dept of Radiation Oncology, University of Texas Southwestern, Dallas, Texas (United States)] [Dept of Radiation Oncology, University of Texas Southwestern, Dallas, Texas (United States)

2012-10-01

190

Concurrent chemoradiotherapy in adjuvant treatment of breast cancer  

Microsoft Academic Search

BACKGROUND: The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. METHODS: Two hundred forty four women having breast cancer were

Nabil Ismaili; Nawfel Mellas; Ouafae Masbah; Sanaa Elmajjaoui; Samia Arifi; Imane Bekkouch; Samir Ahid; Zakaria Bazid; Mohammed Adnane Tazi; Abdelouahed Erraki; Omar El Mesbahi; Noureddine Benjaafar; Brahim El Gueddari; Mohammed Ismaili; Said Afqir; Hassan Errihani

2009-01-01

191

Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas.  

PubMed

The prognosis of patients with central nervous system relapse of aggressive lymphoma is very poor with no therapy established so far. In a prospective multicenter phase II study, we evaluated a potentially curative chemotherapy-only regimen in these patients. Adult immunocompetent patients 65 years of age or under received induction chemotherapy with MTX/IFO/DEP (methotrexate 4 g/m(2) intravenously (i.v.) Day 1, ifosfamide 2 g/m(2) i.v. Days 3- 5 and liposomal cytarabine 50 mg intrathecally (i.th) Day 6) and AraC/TT/DEP (cytarabine 3g/m(2) i.v. Days 1-2, thiotepa 40 mg/m(2) i.v. Day 2 and i.th. liposomal cytarabine 50 mg i.th. Day 3) followed by high-dose chemotherapy with carmustine 400 mg/m(2) i.v. Day -5, thiotepa 2×5 mg/kg i.v. Days -4 to -3 and etoposide 150 mg/m(2) i.v. Days -5 to -3, and autologous stem cell transplantation Day 0 (HD-ASCT). Thirty eligible patients (median age 58 years) were enrolled. After HD-ASCT (n=24), there was a complete remission in 15 (63%), partial remission in 2 (8%) and progressive disease in 7 (29%) patients. Myelotoxicity was the most adverse event with CTC grade 3/4 infections in 12% of MTX/IFO/DEP courses, 21% of AraC/TT/DEP courses and 46% of HD-ASCT courses. The 2-year time to treatment failure was 49%±19 for all patients and 58%±22 for patients completing HD-ASCT. The protocol assessed proved feasible and highly active with long-lasting remissions in a large proportion of patients. (ClinicalTrials.govIdentifier NCT01148173). PMID:23242601

Korfel, Agnieszka; Elter, Thomas; Thiel, Eckhard; Hänel, Matthias; Möhle, Robert; Schroers, Roland; Reiser, Marcel; Dreyling, Martin; Eucker, Jan; Scholz, Christian; Metzner, Bernd; Röth, Alexander; Birkmann, Josef; Schlegel, Uwe; Martus, Peter; Illerhaus, Gerard; Fischer, Lars

2013-03-01

192

Understanding Chemotherapy  

MedlinePLUS

... in together. This will help you share what you learn with family and friends. What is chemotherapy? Chemotherapy is a cancer treatment that uses drugs to destroy cancer cells. It is also called “chemo.” Today, ...

193

Effects of long-term combination chemotherapy on the reticuloendothelial system  

SciTech Connect

The phagocytic and metabolic functions of the reticuloendothelial system (RES) were studied in 20 postoperative cancer patients undergoing long-term combination chemotherapy. Each course included vincristine, methyl-CCNU (day 1) and 5-fluorouracil (days 1-5) every sixth week. The RES-test was performed prior to each course, using /sup 125/I-labeled microaggregated human serum albumin. Total leukocytes, mononuclear cells and platelets were monitored before, during and after each treatment. A significant, initial impairment of the catabolic function of the RES was found (2P . 0.006). A similar, nonsignificant trend was observed in the phagocytic function. The normalization may mirror the large metabolic capacity of the RES. This is further demonstrated by the fact that splenectomized (N . 9) and nonsplenectomized patients did not differ. A significant decrease was also found in total leukocytes and mononuclear cells (2P less than 0.001). Combination chemotherapy induced a similar myelosuppression in both groups, but did not further reduce the mobile RES in asplenic individuals.

Domelloef, L.; Athlin, L.; Berghem, L.

1984-05-15

194

[A case of peritoneal dissemination that exhibited a complete response to systemic chemotherapy following the resection of primary colon cancer].  

PubMed

In June 2010, a 62-year-old man underwent right hemicolectomy with transverse colostomy for advanced ascending colon cancer with peritoneal dissemination(pSE, pN3H0P3M0, fStage IV, R2). One month after surgery, systemic chemotherapy (combination regimen of oxaliplatin injection and S-1 per os; SOX regimen) was introduced for the residual lesion. After completing 4 courses of the SOX regimen, peritoneal dissemination was not detected by abdominal computed tomography. In the same month, laparotomy was performed to close the temporary stoma, in which the lack of peritoneal dissemination was confirmed. After the stoma was closed, although no chemotherapy was administered because of patient preference, he has been free from relapse of the peritoneal dissemination, according to his latest follow-up examinations in June 2012. In this case, resection of the primary lesion immediately followed by a short period of systemic chemotherapy resulted in good control of peritoneal dissemination. Because the effect of these therapies allowed him to undergo stoma closure and to refuse further chemotherapy, he has been able to maintain his quality of life. In cases of reduction surgery for advanced colorectal cancer with unresectable peritoneal dissemination, a minimal resection including the primary lesion to avoid perioperative complications, which could permit the immediate start of systemic chemotherapy, could result in good control of peritoneal dissemination. PMID:23268046

Okamura, Shu; Murata, Kohei; Wada, Yuma; Kato, Ryo; Makino, Shunichiro; Ohwada, Yoshiyuki; Nishigaki, Takahiko; Murakami, Masahiro; Okada, Kazuyuki; Yanagisawa, Tetsu; Ebisui, Chikara; Yokouchi, Hideoki; Kinuta, Masakatsu

2012-11-01

195

Hepatic perfusion abnormalities during treatment with hepatic arterial infusion chemotherapy: Value of CT arteriography using an implantable port system  

Microsoft Academic Search

The purpose of this study was to evaluate CT arteriography (CTA) using an implantable port system in the detection of perfusion abnormalities occurring during hepatic arterial infusion chemotherapy (HAIC). In 51 patients with unresectable primary and metastatic liver tumors, who had implanted port systems for HAIC, CTA examinations through the infusion pump were performed. When perfusion abnormalities were found, selective

Hiroshi Seki; Motomasa Kimura; Takeshi Kamura; Tsutomu Miura

1996-01-01

196

Regional Alterations in the Endocannabinoid System in an Animal Model of Depression: Effects of Concurrent Antidepressant Treatment  

PubMed Central

It has been suggested that disturbances in endocannabinoid signaling contribute to the development of depressive illness; however, at present there is insufficient evidence to allow for a full understanding of this role. To further this understanding, we performed an analysis of the endocannabinoid system in an animal model of depression. Male rats exposed to chronic, unpredictable stress (CUS) for 21 days exhibited a reduction in sexual motivation, consistent with the hypothesis that CUS in rats induces depression-like symptoms. We determined the effects of CUS, with or without concurrent treatment with the antidepressant imipramine (10 mg/kg), on CP55940 binding to the cannabinoid CB1 receptor; whole tissue endocannabinoid content; and fatty acid amide hydrolase (FAAH) activity in the prefrontal cortex, hippocampus, hypothalamus, amygdala, midbrain and ventral striatum. Exposure to CUS resulted in a significant increase in CB1 receptor binding site density in the prefrontal cortex and a decrease in CB1 receptor binding site density in the hippocampus, hypothalamus and ventral striatum. Except in the hippocampus, these CUS-induced alterations in CB1 receptor binding site density were attenuated by concurrent antidepressant treatment. CUS alone produced a significant reduction in N-arachidonylethanolamine (anandamide) content in every brain region examined, which was not reversed by antidepressant treatment. These data suggest that the endocannabinoid system in cortical and subcortical structures is differentially altered in an animal model of depression and that the effects of CUS on CB1 receptor binding site density are attenuated by antidepressant treatment while those on endocannabinoid content are not.

Hill, Matthew N.; Carrier, Erica J.; McLaughlin, Ryan J.; Morrish, Anna C.; Meier, Sarah E.; Hillard, Cecilia J.; Gorzalka, Boris B.

2008-01-01

197

Chemotherapy-induced mucositis: the role of mucin secretion and regulation, and the enteric nervous system.  

PubMed

Alimentary mucositis is a severe, dose-limiting, toxic side effect of cytotoxic chemotherapy and radiotherapy. Patients with mucositis often have reductions or breaks imposed on cytotoxic therapy, which may lead to reduced survival. Furthermore, there is an increased risk of infection and hospitalization, compounding the cost of treatment. There are currently limited therapeutic options for mucositis, and no effective prevention available. Mucin expression and secretion have been shown to be associated with mucositis. Furthermore, mucins exhibit protective effects on the alimentary tract through reducing mechanical and chemical stress, preventing bacterial overgrowth and penetration, and digestion of the mucosa. Additionally, a number of studies have implicated some key neurotransmitters in both mucositis and mucin secretion, suggesting that the enteric nervous system may also play a key role in the development of mucositis. PMID:23827812

Thorpe, Daniel; Stringer, Andrea; Butler, Ross

2013-09-01

198

Central nervous system lesions due to juvenile myelomonocytic leukemia progressed in a boy undergoing first line chemotherapy.  

PubMed

Juvenile myelomonocytic leukemia is a rare malignancy that occurs in pediatric patients. Previous reports, have described leukemic cells may infiltrate many organs, such as the lungs, skin, liver, spleen, and intestines, but not the central nervous system, although central nervous system infiltration remains a point of concern in every patient with acute leukemia. Here, we present one case of a boy with juvenile myelomonocytic leukemia who developed multiple lesions in the brain while undergoing chemotherapy with 6-mercaptopurine and cytarabine. We diagnosed the central nervous system involvement by magnetic resonance imaging, cerebrospinal fluid cytology, and the patient's clinical course. He was treated with a high dose of cytarabine and intrathecal chemotherapy, then with unrelated cord blood stem cell transplantation. He has been in a first complete remission for more than 18 months after cord blood stem cell transplantation without any neurological sequelae. In conclusion, we encountered a boy with juvenile myelomonocytic leukemia who developed central nervous system lesions under standard chemotherapy. We subsequently switched treatment to central nervous system-oriented chemotherapy, which resulted in a good clinical condition and successful cord blood stem cell transplantation. PMID:22461033

Fukushima, Hiroko; Fukushima, Takashi; Hiraki, Akiyoshi; Suzuki, Ryoko; Mahmoud, Shaza S A; Yoshimi, Ai; Nakao, Tomohei; Kato, Keisuke; Kobayashi, Chie; Koike, Kazutoshi; Fukasawa, Masakatsu; Morishita, Yukio; Doisaki, Sayoko; Muramatsu, Hideki; Sumazaki, Ryo

2012-05-01

199

Efficacy and tolerance of a scalp-cooling system for prevention of hair loss and the experience of breast cancer patients treated by adjuvant chemotherapy  

Microsoft Academic Search

The applicability and efficacy of a scalp cooling system were studied in 105 breast cancer patients receiving four cycles of adjuvant chemotherapy with mitoxantrone + cyclophosphamide (NC chemotherapy). Women accepting the scalp-cooling system were compared for alopecia both against those who refused and against a \\

Christel Protière; Katrin Evans; Jacques Camerlo; Marie-Pierre d'Ingrado; Geneviève Macquart-Moulin; Patrice Viens; Dominique Maraninchi; Dominique Genre

2002-01-01

200

Using Attributed Variables in the Implementation of Concurrent and Parallel Logic Programming Systems  

Microsoft Academic Search

Incorporating the possibility of attaching attributes to variables in a logic program- ming system has been shown to allow the addition of general constraint solving capabilities to it. This approach is very attractive in that by adding a few primi- tives any logic programming system can be turned into a generic constraint logic programming system in which constraint solving can

Manuel V. Hermenegildo; Daniel Cabeza Gras; Manuel Carro

1995-01-01

201

Response, toxicity, failure patterns, and survival in five radiation therapy oncology group (RTOG) trials of sequential and\\/or concurrent chemotherapy and radiotherapy for locally advanced non–small-cell carcinoma of the lung  

Microsoft Academic Search

Purpose: The purpose of this study was to assess response, toxicity, failure patterns, and survival differences in three chemotherapy (ChT)\\/radiation therapy (RT) sequencing strategies for locally advanced non-small cell lung cancer (NSCLC).Methods and Materials: Five completed Radiation Therapy Oncology Group (RTOG) trials for Stage II-IIIA\\/B inoperable NSCLC patients employed one of the three following strategy groupings: 1) sequential ChT followed

R. W Byhardt; C Scott; W. T Sause; B Emami; R Komaki; B Fisher; J. S Lee; C Lawton

1998-01-01

202

Concurrent Computing  

NSDL National Science Digital Library

* a preliminary introduction to essential networking concepts, * parallel computing and types of parallel computers, * basics of message-passing parallel computing,* embarrassingly parallel computations,* partitioning and divide-and-conquer strategies,* pipelined computations, * synchronous computations,* programming with shared memory, pthreads,* parallel sorting algorithms,* numerical algorithms,* searching and optimization,* distributed computing using grids,* networks for high-performance cluster computing, and * parallel I/O and parallel file systems.

Apon, Amy

203

Symbolically Modeling Concurrent MCAPI Executions  

NASA Technical Reports Server (NTRS)

Improper use of Inter-Process Communication (IPC) within concurrent systems often creates data races which can lead to bugs that are challenging to discover. Techniques that use Satisfiability Modulo Theories (SMT) problems to symbolically model possible executions of concurrent software have recently been proposed for use in the formal verification of software. In this work we describe a new technique for modeling executions of concurrent software that use a message passing API called MCAPI. Our technique uses an execution trace to create an SMT problem that symbolically models all possible concurrent executions and follows the same sequence of conditional branch outcomes as the provided execution trace. We check if there exists a satisfying assignment to the SMT problem with respect to specific safety properties. If such an assignment exists, it provides the conditions that lead to the violation of the property. We show how our method models behaviors of MCAPI applications that are ignored in previously published techniques.

Fischer, Topher; Mercer, Eric; Rungta, Neha

2011-01-01

204

Regional combined with systemic chemotherapy in unresectable biliary tract cancers: a phase II study.  

PubMed

Unresectable biliary tract cancers have a very poor prognosis. No good systemic chemotherapeutic regimen is available. This study aimed to evaluated the activity and toxicity of a novel approach of combined loco-regional and systemic chemotherapy. Twenty four patients with advanced or metastatic biliary tumors were treated with epiadriamycin 50 mg/m2 and cisplatin 60 mg/m2 administered bolus in proper hepatic artery on day 1, combined with systemic continuous infusion of 5-fluorouracil 200 mg/m2/day, from day 1 to day 14, every 3 weeks. The overall response rate was 8/24 (33%), including one complete response and 7 partial responses (stable disease 46%, progression 21%). The treatment was well tolerated with a minimal hematological toxicity; the major clinical problem was the deep venous thrombosis related to central venous catheter, that occurred in 5 patients (21%). Median overall survival was 14,6 months and 1-year and 2-year survival were 54% and 38% respectively. Performance status improved in 33% of patients and weight gain more than 7% was observed in 17%. This novel combined loco-regional and systemic chemotherapeutic regimen is active and safe for advanced biliary tract cancer patients. PMID:16767908

Cantore, M; Fiorentini, G; Mambrini, A; Rabbi, C; Zamagni, D; Carlone, N; Manni, A; Caudana, R; Torri, T

2003-12-01

205

A design space for multimodal systems: concurrent processing and data fusion  

Microsoft Academic Search

Multimodal interaction enables the user to employ different modalities such as voice, gesture and typing for communicating with a computer. This paper presents an analysis of the integration of multiple communication modalities within an interactive system. To do so, a software engineering perspective is adopted. First, the notion of “multimodal system” is clarified. We aim at proving that two main

Laurence Nigay; Joëlle Coutaz

1993-01-01

206

Tornado: Maximizing Locality and Concurrency in a Shared Memory Multiprocessor Operating System  

Microsoft Academic Search

We describe the design and implementation of Tornado, a new operating system designed from the ground up specifically for today's shared memory multiprocessors. The need for im- proved locality in the operating system is growing as multipro- cessor hardware evolves, increasing the costs for cache misses and sharing, and adding complications due to NUMAness. Tor- nado is optimized so that

Benjamin Gamsa; Orran Krieger; Jonathan Appavoo; Michael Stumm

1999-01-01

207

Systems for Offering Concurrent Enrollment at High Schools and Community Colleges. New Directions for Community Colleges, Number 113. The Jossey-Bass Higher and Adult Education Series.  

ERIC Educational Resources Information Center

The spring 2001 issue of "New Directions for Community Colleges" discusses concurrent enrollment programs and the challenges and issues associated with developing and maintaining such programs. Chapters include: (1) "State Policy and Postsecondary Enrollment Options: Creating Seamless Systems" (Katherine Boswell); (2) "A Model for Implementing a…

Robertson, Piedad F., Ed.; Chapman, Brian G., Ed.; Gaskin, Fred, Ed.

2001-01-01

208

Prognosis of patients with primary central nervous system lymphoma after high-dose chemotherapy followed by autologous stem cell transplantation  

PubMed Central

High-dose chemotherapy followed by autologous stem cell transplantation has been shown to be feasible and highly effective in newly diagnosed primary central nervous system lymphoma. In this retrospective multicenter study, we investigated prognosis and baseline risk factors in patients with primary central nervous system lymphoma who underwent this treatment approach. We retrospectively analyzed 105 immunocompetent patients with primary central nervous system lymphoma who underwent high-dose chemotherapy followed by autologous stem cell transplantation with or without whole brain radiotherapy as first-line consolidation treated at 12 German centers between 1997 and 2011. We estimated survival rates and investigated the impact of age, performance status, serum lactate dehydrogenase level, and deep brain involvement on overall and progression-free survival. Patients were additionally categorized into three prognostic groups according to the Memorial Sloan Kettering Cancer Center prognostic model. After a median follow up of 47 months, median progression-free survival and overall survival was reached after 85 and 121 months; 2- and 5-year survival rates were 82% and 79%, respectively. The Memorial Sloan Kettering Cancer Center prognostic model did not predict survival. Only age revealed some evidence of prognostic relevance. Overall response rate was 95%; of those patients with progressive disease before high-dose chemotherapy, 7 of 20 achieved ongoing complete remission after therapy without whole brain radiation therapy. Transplantation-associated mortality was 2.8%. High-dose chemotherapy followed by autologous stem cell transplantation is a highly effective and safe treatment modality for selected primary central nervous system lymphoma patients. Superiority compared to standard chemotherapy still warrants further investigation.

Schorb, Elisabeth; Kasenda, Benjamin; Atta, Johannes; Kaun, Stephan; Morgner, Anke; Hess, Georg; Elter, Thomas; von Bubnoff, Nikolas; Dreyling, Martin; Ringhoffer, Mark; Krause, Stefan W.; Derigs, Gunter; Klimm, Beate; Niemann, D.; Fritsch, Kristina; Finke, Jurgen; Illerhaus, Gerald

2013-01-01

209

Synthesis and evaluation of folate-based chlorambucil delivery systems for tumor-targeted chemotherapy.  

PubMed

The development of tumor-targeting drug delivery systems, able to selectively transport cytotoxic agents into the tumor site by exploiting subtle morphological and physiological differences between healthy and malignant cells, currently stands as one of the most attractive anticancer strategies used to overcome the selectivity problems of conventional chemotherapy. Owing to frequent overexpression of folate receptors (FRs) on the surface of malignant cells, conjugation of cytotoxic agents to folic acid (FA) via suitable linkers have demonstrated to enhance selective drug delivery to the tumor site. Herein, the chemical synthesis and biological evaluation of two novel folate-conjugates bearing the anticancer agent chlorambucil (CLB) tethered to either an aminoether (4,7,10-trioxa-1,13-tridecanediamine) or a pseudo-?-dipeptide (?-Ala-ED-?-Ala) linker is reported. The two drug delivery systems have been prepared in high overall yields (54% and 34%) through straightforward and versatile synthetic routes. Evaluation of cell specificity was examined using three leukemic cell lines, undifferentiated U937 (not overexpressing FRs, FR(-)), TPA-differentiated U937 (overexpressing FRs, FR(+)), and TK6 (FR(+)) cells. Both conjugates exhibited high specificity only to FR(+) cells (particularly TK6), demonstrating comparable antitumor activity to CLB in its free form. These data confirm the reliability of folate-based drug delivery systems for targeted antitumor therapy; likewise, they lay the foundations for the development of other folate-conjugates with antitumor potential. PMID:22121907

Guaragna, Annalisa; Chiaviello, Angela; Paolella, Concetta; D'Alonzo, Daniele; Palumbo, Giuseppe; Palumbo, Giovanni

2012-01-18

210

Reduced systemic toxicity from superselective chemoembolization compared with systemic chemotherapy in patients with high-risk metastatic gestational trophoblastic disease  

SciTech Connect

Purpose. The efficacy of chemoembolization of primary and metastatic gestational trophoblastic neoplasms was studied. Methods. Six female patients, 19-33 years old, with high-risk trophoblastic disease were subjected to one to five chemoembolizations in 3-week intervals. Three of the patients had metastases to the liver, 2 had local tumor extension to the pelvic wall, and all 5 had failed initial systemic chemotherapy. The sixth patient was treated for a trophoblastic remnant following surgical expression of a tubal pregnancy. For follow-up, beta hCG levels in urine and serum and dynamic or angiocomputed tomograms were obtained in biweekly to 6-month intervals. Results. Two of 3 patients with liver metastases are alive and free of disease 6 and 7 years after initial chemoembolization. The third is alive at 3 years but with evidence of recurrent disease. Two patients treated for locally invasive trophoblastic disease died 3 months and 4 years, respectively, after initial chemoembolization. One had a 21/2-year remission. The patient treated for a trophoblastic remnant in the tube is alive and free of disease at 6-year follow-up. Hematologic toxicity occurred in only one. Conclusion. Selective chemoembolization in our small series of patients with high-risk trophoblastic disease was equally effective as results reported for multi-drug systemic chemotherapy but had markedly lower renal, liver, and hematologic toxicity.

Lang, Erich K. [L.S.U. Medical Center, Department of Radiology (United States)

1997-07-15

211

A laser/EMAT (electromagnetic-acoustic transducer) concurrent weld inspection system  

SciTech Connect

A noncontacting ultrasonic sensor system is being developed for on-line inspection of thick section welds made by a robotic gas metal arc welding (GMAW) system. The sensor system consists of a pulsed laser for generating the ultrasound and an electromagnetic-acoustic transducer (EMAT) for receiving it. The sensor will follow closely behind the weld head and inspect the solidified weld bead for flaws. The main advantage of this technique is that flaws can be found and repaired before they are covered by subsequent welding passes. This is expected to be much simpler and less likely to induce further flaws than current practice since a large amount of otherwise good weld metal need not be removed to reach and repair a flaw. The system also monitors the welding process, i.e., detection of a large number of flaws indicates that the process is no longer operating as planned. In this paper, the technique for detecting incomplete sidewall penetration is demonstrated and methods for improving the system are discussed. 12 refs., 3 figs., 1 tab.

Johnson, J.A.; Carlson, N.M.

1990-01-01

212

Object-oriented concurrent programming  

SciTech Connect

This book deals with a major theme of the Japanese Fifth Generation Project, which emphasizes logic programming, parallelism, and distributed systems. It presents a collection of tutorials and research papers on a new programming and design methodology in which the system to be constructed is modeled as a collection of abstract entities called ''objects'' and concurrent messages passing among objects. The book includes proposals for programming languages that support this methodology, as well as the applications of object-oriented concurrent programming to such areas as artificial intelligence, software engineering, music synthesis, office information systems, and system programming.

Yonezawa, A.; Tokoro, M.

1986-01-01

213

Concurrent systemic AA amyloidosis can discriminate primary sclerosing cholangitis from IgG4-associated cholangitis.  

PubMed

Chronic hepatobiliary inflammatory diseases are not widely acknowledged as underlying disorders of systemic AA amyloidosis, except epidemic schistosomiasis. Among them, primary sclerosing cholangitis (PSC) might initiate amyloid A protein deposition in diverse tissues, giving rise to systemic amyloidosis, due to a progressive and unresolved inflammatory process, and its possible association with inflammatory bowel diseases. Nevertheless, only one such case has been reported in the literature to date. We report a 69-year-old Japanese woman with cirrhosis who was diagnosed with PSC complicated with systemic AA amyloidosis, without any evidence of other inflammatory disorders. As a result of cholestasis in conjunction with biliary strictures and increased serum IgG4, the presence of IgG4(+) plasma cells was examined systemically, resulting in unexpected documentation of Congo-red-positive amyloid deposits, but not IgG4(+) plasma cells, in the liver, stomach and salivary glands. Elevated serum IgG4 is the hallmark of IgG4-related disease, including IgG4-associated cholangitis, but it has also been demonstrated in certain patients with PSC. Amyloid A deposits in multiple organs associated with an indolent clinical course that progresses over many years might have a diagnostic value in discriminating PSC from IgG4-associated cholangitis. PMID:22253527

Kato, Takehiro; Komori, Atsumasa; Bae, Sung-Kwan; Migita, Kiyoshi; Ito, Masahiro; Motoyoshi, Yasuhide; Abiru, Seigo; Ishibashi, Hiromi

2012-01-14

214

Scalable Concurrent Programming Project.  

National Technical Information Service (NTIS)

The Scalable concurrent Programming Project is intended to provide significant advances in scalable, high-performance, concurrent programming technology. This is to be achieved through innovations in compiler technology and programming methods. The resear...

S. Taylor

1993-01-01

215

The ADAPTIVE Service Executive: An Object-Oriented Architecture for Configuring Concurrent Distributed Communications Systems  

Microsoft Academic Search

The ADAPTIVE Service eXecutive ( ASX) is an object- oriented framework that enhance the d evelopment of dis- tributed applications across a range of operating system platforms. The components inASX were developed using object-oriented design techniques and C++ language fea- tures in order to simplify the use of OS mechanisms that pro- vide interprocess communication, communication port de- multiplexing, explicit

Douglas C. Schmidt; Tatsuya Suda

1994-01-01

216

The Effects of Mobile Pedestrian Navigation Systems on the Concurrent Acquisition of Route and Survey Knowledge  

Microsoft Academic Search

In this paper we report results of an experiment that investigates the effects of mobile pedestrian navigation systems on the development of route and survey knowledge acquired by the users. In the experiment directions were presented incrementally step-by-step in different modalities (i.e. audio, graph- ics) and through different media (PDA, clip-on display). The experiment has been carried out in the

Antonio Krüger; Ilhan Aslan; Hubert D. Zimmer

2004-01-01

217

Knowledge-based hand tool selection in concurrent design of mechanical systems  

Microsoft Academic Search

Selection of hand tools for cost-effective assembly and maintenance of a mechanical system has a significant impact on its life-cycle cost. A knowledge-based automated procedure for the selection of hand tools needed to efficiently carry out fastening operations in a mechanical assembly is presented. The objective is to select a tool that is applicable to a particular fastening operation, minimizes

Nagarjun V. Yetukuri; Ranko Vujosevic

1995-01-01

218

Global warming and concurrent reorganization of fluvial systems: cautionary tales from the PETM  

NASA Astrophysics Data System (ADS)

Under ice-free climatic conditions of the Paleogene there were several episodes of brief and rapid warming that are termed 'hyperthermals', the largest of which is the Paleocene Eocene Thermal Maximum (PETM). Often considered as analogs to present-day warming, it is important to study and understand the response of climatic, hydrologic and sedimentary systems to hyperthermal temperature changes. Here we investigate the response of fluvial systems in western North America to the PETM. This study is based on terrestrial sections from Laramide basins where the PETM can be identified on the basis of biostratigraphic indicators and carbon isotope excursions (Bighorn, Piceance Creek, Powder River and Williston Basins), and where the PETM can be inferred based on carbon isotope data alone (Denver, Huerfano, Tornillo, and Wind River Basins). Each PETM section occupies a different approximate position along the hypothetical longitudinal profile of the basin river system (e.g. headland, alluvial fan, braided river, meandering river, etc.), and in this manner the response of fluvial responses to PETM climate change can be considered at the watershed scale. Localities closest to the paleorange front are characterized by coarse sediment deposition on an unconformity, suggesting that sediment through-flow occurred prior to the PETM but high-energy flow and sediment deposition took place during the PETM. Closer to the axis of the watershed there is no obvious unconformity, but a change from fine to coarse lithofacies are observed. At localities furthest from the paleorange front it is much more difficult to discern any sedimentological response to the PETM. Thus overall the response of fluvial systems to the PETM does not appear uniform, but dependent on location relative to highlands. In order for fluvial systems to display this spatial variability, a large amount of coarse sediment must have been mobilized in the highlands and transported basinward during the PETM. This increased sediment mobilization in turn is indicative of a change to more seasonal precipitation, as indicated by the onset of paleosol/redbed formation in many of the PETM sections. Considered together, the inference that (1) rapid global warming may be expressed as more seasonal precipitation, and that (2) this change in watershed hydrology can have profound influences on fluvial sediment transport and deposition, may have important predictive power when considering the impact to warming now and in the near future.

Fricke, H. C.; Foreman, B. Z.

2012-12-01

219

Slicing Concurrent Java Programs  

Microsoft Academic Search

Although many slicing algorithms have been proposed for object-oriented programs, no slicing algorithm has been proposed which can be used to handle the problem of slicing concurrent Java programs correctly. In this paper, we propose a slicing algorithm for concurrent Java programs. To slice concurrent Java programs, we present a dependence-based representation called multithreaded dependence graph, which extends previous dependence

Jianjun Zhao

1999-01-01

220

Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study  

Microsoft Academic Search

Brain gray matter alterations have been reported in cross-sectional magnetic resonance imaging (MRI) studies of breast cancer\\u000a patients after cancer treatment. Here we report the first prospective MRI study of women undergoing treatment for breast cancer,\\u000a with or without chemotherapy, as well as healthy controls. We hypothesized that chemotherapy-associated changes in gray matter\\u000a density would be detectable 1 month after treatment,

Brenna C. McDonaldSusan; Susan K. Conroy; Tim A. Ahles; John D. West; Andrew J. Saykin

2010-01-01

221

Explicit modeling and concurrent processing in the simulation of multibody dynamic systems  

NASA Technical Reports Server (NTRS)

The objective is to present the activities at TRW in developing the capability to simulate the behavior of large flexible multibody space structures. The features of the simulation tools are: (1) to accommodate all rigid/flexible body degrees-of-freedom which incorporate the control system models and external forces, (2) to provide the flexibility to incorporate engineering-defined models and to retain parameters of significance to the engineer, (3) to reduce the computation cost by one order of magnitude (two orders of magnitude compared to a CRAY 1S), and (4) to keep it versatile so that radical variations in anticipated space structures can be accommodated. The current computer tools to simulate multibody systems appear not only to be very costly and time consuming, but also do not produce the desired fidelity of the mathematical models. In summary, a multibody simulation tool will be developed in the near future which will allow solution of the dynamics and controls of the deployment of the LDR backup structure, or the problem associated with the robotic assembly of the structure. The tools will allow the engineer to define the modeling technique and solve problems in less time and at reduced cost.

Gluck, R.

1988-01-01

222

Concurrent Graph and Term Graph Rewriting  

Microsoft Academic Search

Graph Rewriting Systems are a powerful formalism for the specification of parallel and distributed systems, and the corresponding theory is rich of results concerning parallelism and concurrency. I will review the main results of the theory of concurrency for the algebraic approach to graph rewriting, emphasizing the relationship with the theory of Petri nets. In fact, graph rewriting systems can

Andrea Corradini

1996-01-01

223

High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system.  

PubMed

Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood. Median survival with surgery and standard chemotherapy is less than 12 months. In an attempt to improve outcome, patients were treated with aggressive surgical resection and multi-agent chemotherapy, followed by high dose chemotherapy with autologous stem cell rescue. Nine consecutive children (median age 21 months) were diagnosed with AT/RT at the University of California San Francisco Childrens Hospital from 1997 to 2007 and treated with this aggressive approach. Diagnosis was confirmed using molecular markers. There are two long-term survivors (78 and 98 months from diagnosis). One additional patient is alive with disease. Three patients died of disease during therapy. Three patients died of disease after therapy was complete. There were no toxic deaths. Two of nine patients treated for AT/RT at our institution with high dose chemotherapy and autologous bone marrow transplant are long-term survivors, suggesting that a subset of patients can be cured with this approach. PMID:19936623

Nicolaides, Theodore; Tihan, Tarik; Horn, Biljana; Biegel, Jaclyn; Prados, Michael; Banerjee, Anuradha

2010-05-01

224

IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses.  

PubMed

Central nervous system (CNS) autoimmunity such as uveitis and multiple sclerosis is accompanied by Th1 and Th17 responses. In their corresponding animal models, experimental autoimmune uveitis (EAU) and experimental autoimmune encephalomyelitis (EAE), both responses are induced and can drive disease independently. Because immune responses have inherent plasticity, therapeutic targeting of only one pathway could promote the other, without reducing pathology. IL-27p28 antagonizes gp130, required for signaling by IL-27 and IL-6, which respectively promote Th1 and Th17 responses. We therefore examined its ability to protect the CNS by concurrently targeting both effector responses. Overexpression of IL-27p28 in vivo ameliorated EAU as well as EAE pathology and reduced tissue infiltration by Th1 and Th17 cells in a disease prevention, as well as in a disease reversal protocol. Mechanistic studies revealed inhibition of Th1 and Th17 commitment in vitro and decreased lineage stability of pre-formed effectors in vivo, with reduction in expression of gp130-dependent transcription factors and cytokines. Importantly, IL-27p28 inhibited polarization of human T cells to the Th1 and Th17 effector pathways. The ability of IL-27p28 to inhibit generation as well as function of pathogenic Th1 and Th17 effector cells has therapeutic implications for controlling immunologically complex autoimmune diseases. PMID:24021664

Chong, Wai Po; Horai, Reiko; Mattapallil, Mary J; Silver, Phyllis B; Chen, Jun; Zhou, Ru; Sergeev, Yuri; Villasmil, Rafael; Chan, Chi-Chao; Caspi, Rachel R

2014-05-01

225

A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.  

PubMed

Biochemical analysis of central nervous system proteins and nucleic acids requires fresh-tissue homogenates, whereas immunohistochemistry usually is performed in sections prepared from perfusion-fixed tissue. Post-mortem immersion-fixation is possible, but largely impairs morphological preservation and protein antigenicity. Here, we present a simple, fast and versatile protocol allowing concurrent biochemical and immunohistochemical analysis, including pre-embedding immunoelectron microscopy, using tissue from the same animal. The protocol includes a brief transcardiac perfusion with ice-cold, oxygenated and glucose-supplemented artificial cerebrospinal fluid to maintain brain tissue alive, prior to isolation of regions of interest, followed by homogenisation for biochemistry or immersion-fixation for immunohistochemistry. We provide several examples demonstrating that this protocol allows optimal biochemical and morphological analysis, characterised with optimal sensitivity and preservation of tissue structure, along with a reduction of artefacts typically seen in perfusion-fixed tissue. This protocol should find widespread applications for combining analytical methods in tissue from the same animal, thereby reducing the number of mice required for a given experiment. PMID:24325300

Notter, Tina; Panzanelli, Patrizia; Pfister, Sandra; Mircsof, Dennis; Fritschy, Jean-Marc

2014-01-01

226

Concurrent Use of an Audience Response System at a Multi-Campus College of Pharmacy  

PubMed Central

Objective. To assess the impact of an audience response system (ARS) on student engagement at a multi-campus college of pharmacy. Methods. An online questionnaire was designed and administered to measure the impact of an ARS on student engagement, distance education, projected use, and satisfaction among pharmacy students for a course delivered across 3 sites via synchronous video transmission. Results. Students reported that use of the ARS made it easier to participate (85.3%) and helped them to focus (75.7%) in classes when the lecturer was physically at a different site. They also valued that the ARS allowed them to respond anonymously (93.2%). A minority of students indicated that use of the ARS was distracting (11.8%). Conclusions. Implementation of an ARS was associated with positive student perceptions of engagement and may improve feelings of connectedness among students at schools with multiple sites. Use of ARSs could also represent a cognitive intercession strategy to help reduce communication apprehension.

Alkhateeb, Fadi M.; Singh-Franco, Devada

2012-01-01

227

Alternating hepatic arterial infusion and systemic chemotherapy for stage IV colorectal cancer with synchronous liver metastasis.  

PubMed

Among 41 patients with synchronous liver metastases of colorectal cancer, 15 patients underwent synchronous resection of their liver metastases and achieved a median survival time (MST) of 1,441 days (versus 748 days for the 26 patients without resection, p=0.038), a median relapse-free survival time of 652 days (MST not reached), and a recurrence rate in the residual liver of 20% (3/15 patients). The alternating hepatic arterial infusion and systemic chemotherapy showed partial response (PR) in 6 cases, stable disease (SD) in 8 cases, and progressive disease (PD) in 1 case (n=15/26). They had an objective response rate of 40% (6/15), tumor control rate (>/= SD) of 93.3% (14/15), one-year progression-free survival rate of 35.7%, 50% time to progression of 270 days, one-year survival rate of 76.2%, and two-year survival rate of 50.8% (MST not reached). Grade 3 leucopenia was observed in 2/15 patients (13.3%). These results suggest that the present alternating therapy may become a standard regimen for patients in whom synchronous resection of liver metastases is impossible and patients who have stage IV colorectal cancer with a risk of recurrence in the remnant liver and/or at extrahepatic sites such as the lungs. PMID:16969507

Mukai, Masaya; Oida, Yasuhisa; Tajima, Takayuki; Kishima, Kyoko; Ninomiya, Hiromi; Sato, Shinkichi; Nakamura, Masato; Nakasaki, Hisao; Makuuchi, Hiroyasu

2006-10-01

228

Anticancer chemotherapy  

SciTech Connect

Despite troubled beginnings, anticancer chemotherapy has made significant contribution to the control of cancer in man, particularly within the last two decades. Early conceptual observations awakened the scientific community to the potentials of cancer chemotherapy. There are now more than 50 agents that are active in causing regression of clinical cancer. Chemotherapy's major conceptual contributions are two-fold. First, there is now proof that patients with overt metastatic disease can be cured, and second, to provide a strategy for control of occult metastases. In man, chemotherapy has resulted in normal life expectancy for some patients who have several types of metastatic cancers, including choriocarcinoma, Burkitt's lymphomas, Wilm's tumor, acute lymphocytic leukemia, Hodgkins disease, diffuse histiocytic lymphoma and others. Anticancer chemotherapy in Veterinary medicine has evolved from the use of single agents, which produce only limited remissions, to the concept of combination chemotherapy. Three basic principles underline the design of combination chemotherapy protocols; the fraction of tumor cell killed by one drug is independent of the fraction killed by another drug; drugs with different mechanisms of action should be chosen so that the antitumor effects will be additive; and since different classes of drugs have different toxicities the toxic effects will not be additive.

Weller, R.E.

1988-10-01

229

The impact of systemic chemotherapy on testicular FDG activity in young men with Hodgkin's lymphoma  

PubMed Central

Purpose Based on prior reports suggesting a positive correlation between fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/CT and total sperm count and concentration, we sought to identify changes in testicular FDG uptake over the course of chemotherapy in young men with Hodgkin’s lymphoma. Methods Fifty-two patients with a mean age of 24.2 years (range 15.5–44.4) at diagnosis monitored with FDG PET/CT to assess treatment response for Hodgkin’s lymphoma were selected for this retrospective analysis under an Institutional Review Board waiver. Of the patients, 26 were treated with a chemotherapy regimen known to cause prolonged and sometimes permanent azoospermia (BEACOPP—bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone) and 26 with a regimen known to have a much milder effect on gonadal function (ABVD—doxorubicin, bleomycin, vincristine, and dacarbazine). Each patient underwent one FDG PET/CT before treatment and at least one FDG PET/CT after start of chemotherapy. In all examinations, FDG activity was measured in the testes with different quantification metrics: maximum standardized uptake value (SUVmax), SUVmean, functional volume (FV) and total testicular glycolysis (TTG), and blood pool activity determined (SUVmean). Results Testicular FDG uptake (SUVmax) was significantly associated with blood pool activity (p<0.001). Furthermore, testicular FDG uptake metrics incorporating volume (e.g., FV and TTG) were associated with age. There was no significant change in SUVmax, SUVmean, FV, and TTG from the PET/CT at baseline to the PET/CTs over the course of chemotherapy either for patients treated with BEACOPP or for patients treated with ABVD. Conclusion For patients undergoing chemotherapy for Hodgkin’s lymphoma, there is a significant association between testicular FDG uptake and blood pool activity, but no significant changes in FDG uptake over the course of chemotherapy. Therefore, FDG uptake may not be a feasible surrogate marker for fertility monitoring in patients with Hodgkin’s lymphoma undergoing chemotherapy.

Burger, Irene A.; Vargas, Hebert Alberto; Goldman, Debra A.; Gonen, Mithat; Kumar, Anita; Zelenetz, Andrew D.; Schoder, Heiko; Hricak, Hedvig

2014-01-01

230

The programming language concurrent pascal  

Microsoft Academic Search

The paper describes a new programming language for structured program- ming of computer operating systems. It extends the sequential programming language Pascal with concurrent programming tools called processes and moni- tors. Part I explains these concepts informally by means of pictures illustrating a hierarchical design of a simple spooling system. Part II uses the same exam- ple to introduce the

Per Brinch Hansen

1975-01-01

231

Relaxed Concurrency Control in Software Transactional Memory  

Microsoft Academic Search

Some of today's TM systems implement the two-phase-locking (2PL) algorithm which aborts transactions every time a conflict occurs. 2PL is a simple algorithm that provides fast transactional operations. However, it limits concurrency in benchmarks with high contention because it increases the rate of aborts. We propose the use of a more relaxed concurrency control algorithm to provide better concurrency. This

Utku Aydonat; Tarek S. Abdelrahman

2012-01-01

232

Surviving Chemotherapy  

NSDL National Science Digital Library

Lecture outlinne, with embedded notes, to serve as a starting point for in-class discussion, student research and presentation. Lecture provides a review of cancer, chemotherapy, risk factors for cancer, and correlations between all and nutrition.

Dr. Margaret A McMichael (Baton Rouge Community College Biological Sciences)

2008-08-15

233

MCM/Chip Concurrent Engineering Validation.  

National Technical Information Service (NTIS)

We report on the MOSTsoftware system, which implements a concurrent physical design environment for Multi-Chip Modules. The system integrates the work of design teams distributed across a network and using different CAD systems. At present the following s...

H. Moreno, S. Stark

1992-01-01

234

MCM/Chip Concurrent Engineering Validation.  

National Technical Information Service (NTIS)

We report on the MOST software system, which implements a concurrent physical design environment for Multi-Chip Modules. The system integrates the work of design teams distributed across a network and using different CAD systems. At present the following ...

H. Moreno, S. Stark

1992-01-01

235

The effect of rice-seeding rate and fish stocking on the floodwater ecology of the trench of a concurrent, direct-seeded rice-fish system  

Microsoft Academic Search

Concurrent rice-fish systems in the Mekong Delta, Vietnam, are characterized by a rice field surrounded by a trench (on average 1000 m2, covering 15–20% of the field surface). Rice is direct seeded and fish are reared in polyculture. The most common species for polyculture are silver barb Barbodes gonionotus (Bleeker), common carp Cyprinus carpio L. and Nile tilapia Oreochromis niloticus

Nico Vromant; Nguyen T. H. Chau; Frans Ollevier

2001-01-01

236

The effect of rice seeding rate and fish stocking on the floodwater ecology of the rice field in direct-seeded, concurrent rice-fish systems  

Microsoft Academic Search

Concurrent, rice-fish systems in the Mekong Delta, Vietnam, are characterized by a rice field surrounded by a trench. Rice is direct seeded and fish are reared in polyculture. The most common species for polyculture are silver barb Barbodes gonionotus (Bleeker), common carp Cyprinus carpio L. and Nile tilapia Oreochromis niloticus (L.). In a 1996–97 rice-fish experiment, the effects of (1)

Nico Vromant; Nguyen T. H. Chau; Frans Ollevier

2001-01-01

237

Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified According to the Retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin.  

National Technical Information Service (NTIS)

Background: We evaluate the long-term survival of patients with peritoneal carcinomatosis (PC) treated with systemic chemotherapy regimens, and the impact of the of the retrospective peritoneal disease severity score (PSDSS) on outcomes. Methods: One hund...

A. Stojadinovic J. Doerfer J. Esquivel J. O. Pelz T. C. Chua

2010-01-01

238

Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents.  

PubMed

Involvement of the central nervous system (CNS) in multiple myeloma (MM) is a rare complication, with reported survival of <6 months. This report describes 37 MM patients with leptomeningeal and/or parenchymal brain involvement treated at our institution and identifies factors associated with long-term survival. From January 1999 to December 2010, 37 patients with CNS MM were evaluated at our institution. Clinical characteristics, treatment and survival were retrospectively collected. CNS disease was present at MM diagnosis in 24% and at relapse in 76%. Plasma cell leukemia (40%) and skull plasmacytomas (65%) were common, suggesting haematological and contiguous spread. Intrathecal (IT) chemotherapy was used in 81%, cranial and/or spinal irradiation in 78%, and various systemic therapies [immunomodulatory agents (IMiDs) (51%), cisplatin-based (DPACE; cisplatin, doxorubicin, cyclophosphamide, etoposide) (27%), bortezomib (19%), alkylators (11%), dexamethasone alone (8%), auto-transplant (5%)]. Median survival from CNS disease was only 4·6 months [95% confidence interval (CI): 2·8-6·7]; however, nine patients had prolonged survival (median: 17·1 months, 95% CI: 13·2-67·4). In general, these long-term survivors were treated with radiotherapy, multi-dosing IT chemotherapy, and IMiD-containing therapy. CNS MM is a highly aggressive disease but in our experience, long-term survival can be achieved with the combination of multi-dosing IT chemotherapy, radiation and IMiD-based therapy. PMID:23772701

Chen, Christine I; Masih-Khan, Esther; Jiang, Haiyan; Rabea, Ahmed; Cserti-Gazdewich, Christine; Jimenez-Zepeda, Victor H; Chu, Chia-Min; Kukreti, Vishal; Trudel, Suzanne; Tiedemann, Rodger; Tsang, Richard; Reece, Donna E

2013-08-01

239

Keeping Pace With Oral Chemotherapy  

PubMed Central

Purpose: Although the rising number of oral chemotherapy agents offers many patients with cancer a more convenient and less invasive treatment option compared with infusion therapy, multiple risks and challenges have been identified with the oral regimen, including dosing errors, drug interactions, and nonadherence or overadherence. Until recently, cancer care providers had maintained a considerable amount of control, including the certainty that the right drug was being administered in the right dose, via the right route, at the right time, and to the right patient—all of which were meticulously documented in patient records. In contrast, oral chemotherapy takes much of the control out of the clinician's hands and places tremendous responsibility on the patient, raising a number of adherence and control issues. Studies regarding oral hormonal therapy for breast cancer have described adherence rates ramping down from 83% to 77% within the first 2 years of therapy. These figures continue to decrease over time to a range of 50% to 64% within 4 to 5 years. On the basis of these data and a literature review, we developed a program to promote adherence to oral anticancer protocols. Methods: Our team took a proactive, team-focused approach and established protocols at a time when oral chemotherapies were still at a low volume. In addition to infrastructures, policies, and procedures promoting collaborative communications among physicians, nurses, and pharmacists, we developed an in-depth educational component that provides the linchpin for ensuring an effective oral chemotherapy program. Our program focuses on three key pillars: education, communication, and follow-up. Our project team first conducted an inclusive review of available literature, with the objective of designing processes that would help our program directly address existing risks and challenges. Then we introduced concepts for the formalized program to our cancer center physicians, whose support was paramount to successful implementation. The next step was to start the program with a mandatory in-service for all clinical staff, which included a presentation of the research evidence that prompted the creation of this model for oral chemotherapy. To enhance patient understanding, our team provides printed materials, individualized calendars, and in some cases preloaded pillboxes to assist patients. Concurrently, our nurses provide weekly telephone intervention for the second and third months and monthly phone interventions thereafter. Communication is key to the success of the program. This includes the use of a translation service to ensure effective communication with all non–English-speaking patients. We intervene early for those patients with financial barriers and offer a variety of referrals and resources for emotional, nutritional, and patient support services, including transportation issues. Results: Since the inception of the program, the in-service has been incorporated into our new employee orientation. At the same time, a growing number of cancer center physicians are embracing the program. The program has received the attention of the Oncology Roundtable, which developed a Webinar around the topic, and been described in a feature article in an oncology journal. Finally, our team has been tapped to educate other pharmacists regarding oral agents, toxicity profiles, and safe handling. Conclusion: By combining safeguards, patient education strategies, intensive follow-up, and a system of effective checks and balances, our center is taking significant steps to maximize patient safety and oral chemotherapy treatment effectiveness, while keeping pace with the rapidly occurring changes in oncology practice.

Barefoot, Jeanette; Blecher, Carol S.

2012-01-01

240

STU attractors from vanishing concurrence  

SciTech Connect

Concurrence is an entanglement measure characterizing the mixed state bipartite correlations inside of a pure state of an n-qubit system. We show that after organizing the charges and the moduli in the STU model of N=2, d=4 supergravity to a three-qubit state, for static extremal spherically symmetric Bogomolny-Prasad-Sommerfield (BPS) black-hole solutions the vanishing condition for all of the bipartite concurrences on the horizon is equivalent to the attractor equations. As a result of this, the macroscopic black hole entropy given by the three-tangle can be reinterpreted as a linear entropy characterizing the pure state entanglement for an arbitrary bipartite split. Both for the BPS and non-BPS cases, explicit expressions for the concurrences are obtained, with their vanishing on the horizon is demonstrated.

Levay, Peter; Szalay, Szilard [Department of Theoretical Physics, Institute of Physics, Budapest University of Technology and Economics, H-1521 Budapest (Hungary)

2011-02-15

241

Scalp hypothermia to prevent chemotherapy-induced alopecia is effective and safe: A pilot study of a new digitized scalp-cooling system used in 74 patients  

Microsoft Academic Search

Goals. The aim of this study was to examine the efficacy and safety of a new digitized, controlled, scalp-cooling system to prevent chemotherapy-induced alopecia.Method. Seventy-four female cancer patients who received 13 varying chemotherapy regimens were included in a nonrandomized pilot study. The Digni 2–3 with Dignicap system consists of a refrigerator unit and a control unit integrated into a mobile

Mona Ridderheim; Maria Bjurberg; Anita Gustavsson

2003-01-01

242

Adjuvant Systemic Chemotherapy with Gemcitabine for Stage IV Pancreatic Cancer: A Preliminary Report of Initial Experience  

Microsoft Academic Search

Background: The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. Patients and Methods: Nineteen patients with stage IV pancreatic cancer who had pancreatic resection with curative intent during the 5 years up to February 2003 were enrolled

Isao Kurosaki; Katsuyoshi Hatakeyama

2005-01-01

243

Carcinoembryonic antigen in monitoring of response to systemic chemotherapy in patients with metastatic colorectal cancer  

Microsoft Academic Search

The response to chemotherapy of solid tumors is generally assessed by measuring tumors visualized by imaging. However, the response assessment based on imaging is not always feasible because patients often have disease not measurable by imaging, such as diffuse peritoneal dissemination. We evaluated the correlation between the change on imaging and change in CEA levels for assessing chemotherapeutic response of

Wei-Shu Wang; Jen-Kou Lin; Tzu-Chen Lin; Tzeon-Jye Chiou; Jin-Hwang Liu; Frank S. Fan; Chueh-Chuan Yen; Wei-Shone Chen; Jeng-Kae Jiang; Shung-Haur Yang; Huann-Sheng Wang; Po-Min Chen

2001-01-01

244

The concurrent language, Shared Prolog  

Microsoft Academic Search

Shared Prolog is a new concurrent logic language. A Shared Prolog system is composed of a set of parallel agents that are Prolog programs extended by a guard mechanism. The programmer controls the granularity of parallelism, coordinating communication and synchronization of the agents via a centralized data structure. The communication mechanism is inherited from the blackboard model of problem solving.

Antonio Brogi

1991-01-01

245

Controlling concurrency using locking protocols  

Microsoft Academic Search

This paper is concerned with the problem of developing locking protocols for ensuring the consistency of database systems that are accessed concurrently by a number of independent transactions. It is assumed that the database is modelled by a directed acyclic graph whose vertices correspond to the database entities, and whose arcs correspond to certain locking restrictions. Several locking protocols are

Zvi Kedem; Abraham Silberschatz

1979-01-01

246

Investigating Concurrency in Weapons Programs.  

National Technical Information Service (NTIS)

Concurrency in a weapons program -- the actual production of the weapons system while some portions of the design are still being completed -- has been a topic of debate for decades. While there have been some investigations into certain programs that poi...

D. Birchler E. Groo G. Christle

2010-01-01

247

Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: Updated results of a randomized multicentric trial in advanced head-and-neck cancer  

SciTech Connect

Purpose: To prove an expected benefit of concurrent radiochemotherapy (RCT), a two-arm randomized multicentric study was performed. In a subgroup analysis the influence of pretherapeutical hemoglobin level (p-Hb) on survival under locoregional control (SLC) was tested. Patients and Methods: The study included primarily untreated Stage III/IV (International Union Against Cancer [UICC]) oropharyngeal and hypopharyngeal carcinomas. Patients were randomized to receive either hyperfractionated (hf) and accelerated (acc) RCT with two cycles 5-fluorouracil (600 mg/m{sup 2}/day) and carboplatin (70 mg/m{sup 2}/day) on Days 1-5 and 29-33 or hf-acc radiotherapy (RT) alone. Total RT dose in both arms was 69.9 Gy in 38 days in concomitant boost technique. Results: After a median follow-up time of 57 months, SLC is significantly better in RCT than in RT (p = 0.01), with median SLC of 17 months and 11 months, respectively. Also overall survival (OS) shows a benefit for RCT (p 0.016), with a median survival of 23 months for RCT and 16 months for RT. However, the benefit in SLC and OS is not seen in hypopharyngeal carcinomas. In a multivariate analysis of oropharyngeal cancer patients, p-Hb levels lower than 12.7 g/dL resulted in lower SLC compared with higher p-Hb levels up to 13.8 g/dL. P-Hb levels >13.8 g/dL did not further improve SLC. Conclusions: Hyperfractionated-accelerated RCT is superior to hf-acc RT in oropharyngeal carcinomas. P-Hb levels >13.8 g/dL do not further improve SLC.

Semrau, Robert [Department of Radiation Oncology, University of Cologne, Cologne (Germany)]. E-mail: Robert.Semrau@uk-koeln.de; Mueller, Rolf-Peter [Department of Radiation Oncology, University of Cologne, Cologne (Germany); Stuetzer, Hartmut [Department of Medical Statistics and Epidemiology, University of Cologne, Cologne (Germany); Staar, Susanne [Department of Radiation Oncology, Krankenhaus-St-Juergens, Bremen (Germany); Schroeder, Ursula [ENT Department, University of Cologne, Cologne (Germany); Guntinas-Lichius, Orlando [ENT Department, University of Cologne, Cologne (Germany); Kocher, Martin [Department of Radiation Oncology, University of Cologne, Cologne (Germany); Eich, Hans Theodor [Department of Radiation Oncology, University of Cologne, Cologne (Germany); Dietz, Andreas [ENT Department, University of Leipzig, Leipzig (Germany); Flentje, Michael [Department of Radiation Oncology, University of Wuerzburg, Wuerzburg (Germany); Rudat, Volker [Department of Radiation Oncology, University of Hamburg, Hamburg (Germany); Volling, Peter [ENT Department, Evangelisches Krankenhaus Oldenburg, Oldenburg (Germany); Schroeder, Michael [ENT Department, Klinikum Kassel, Kassel (Germany); Eckel, Hans Edmund [ENT Department, Landeskrankenhaus Klagenfurt, Klagenfurt (Austria)

2006-04-01

248

Improving Electronic Oral Chemotherapy Prescription: Can We Build a Safer System?  

PubMed Central

Introduction: To prevent oral chemotherapy prescription errors, we enhanced a prescription-writing module in an ambulatory electronic medical record. We sought to describe the enhancement, examine its performance to date, and identify opportunities for improvement. Methods: Enhancements to the oral chemotherapy writing module included weight- and body surface area–based dosing, fields for cancer diagnosis and intent of therapy (curative v palliative), and dose-limit warnings. We studied all prescriptions for 18 oral chemotherapies generated by oncology clinicians during the first 17 months after the safe prescribing enhancements were introduced, from May 1, 2010, to October 1, 2011. We examined the frequency with which clinicians used the new features, the number and type of alerts generated, and clinician actions in response to alerts. Results: Six hundred clinicians generated 6,673 prescriptions for 2,043 patients. Six drugs—temozolomide, capecitabine, lenalidomide, hydroxyurea, imatinib, and erlotinib—accounted for 5,512 of all oral chemotherapy prescriptions (83%). Prescribers indicated the intent of therapy 13% of the time and listed the patient's cancer diagnosis 46% of the time. Prescribers customized their instructions using a free-text field in 64% of prescriptions. Clinicians' 6,673 prescription attempts triggered 395 dose-limit warnings (5%), mostly for temozolomide. Clinicians ignored most (96%) warnings, because current dosing recommendations exceeded the dose-limit warnings for the alerted medications. Conclusion: Oncology clinicians readily accepted features designed to enhance oral chemotherapy safety. Additional enhancements are needed to facilitate prescriptions with complex dosing regimens and to provide dose-limit warnings that reflect current clinical practice.

Weingart, Saul N.; Mattsson, Thea; Zhu, Junya; Shulman, Lawrence N.; Hassett, Michael

2012-01-01

249

Concurrent engineering research center  

NASA Technical Reports Server (NTRS)

The projects undertaken by The Concurrent Engineering Research Center (CERC) at West Virginia University are reported and summarized. CERC's participation in the Department of Defense's Defense Advanced Research Project relating to technology needed to improve the product development process is described, particularly in the area of advanced weapon systems. The efforts committed to improving collaboration among the diverse and distributed health care providers are reported, along with the research activities for NASA in Independent Software Verification and Validation. CERC also takes part in the electronic respirator certification initiated by The National Institute for Occupational Safety and Health, as well as in the efforts to find a solution to the problem of producing environment-friendly end-products for product developers worldwide. The 3M Fiber Metal Matrix Composite Model Factory Program is discussed. CERC technologies, facilities,and personnel-related issues are described, along with its library and technical services and recent publications.

Callahan, John R.

1995-01-01

250

On Optimistic Methods for Concurrency Control.  

National Technical Information Service (NTIS)

Most current approaches to concurrency control in database systems rely on locking of a data objects as a control mechanism. In this paper, two families of non-locking concurrency controls are presented. The methods used are ('optimistic' in the sense tha...

H. T. Kung J. T. Robinson

1979-01-01

251

Optimistic concurrency control for abstract data types  

Microsoft Academic Search

A concurrency control technique is optimistic if it allows transactions to execute without synchronization, relying on commit-time validation to ensure serializability. This paper describes several new optimistic concurrency control techniques for objects in distributed systems, proves their correctness and optimality properties, and characterizes the circumstances under which each is likely to be useful. These techniques have the following novel aspects.

Maurice Herlihy

1986-01-01

252

The family of concurrent logic programming languages  

Microsoft Academic Search

Concurrent logic languages are high-level programming languages for parallel and distributed systems that offer a wide range of both known and novel concurrent programming techniques. Being logic programming languages, they preserve many advantages of the abstract logic programming model, including the logical reading of programs and computations, the convenience of representing data structures with logical terms and manipulating them using

Ehud Y. Shapiro

1989-01-01

253

Neoadjuvant chemotherapy or chemoradiotherapy for locally advanced esophageal cancer.  

PubMed

In patients with operable esophageal cancer, there is evidence supporting the use of preoperative chemotherapy or preoperative chemoradiation. The addition of radiotherapy to chemotherapy seems more relevant for the more locally advanced cancers. There is a need to examine in trials more modern chemotherapy combinations with and without concurrent radiation and for research into assessing methods for predicting outcomes from neoadjuvant therapy as part of the paradigm of therapy for this disease. PMID:24199701

Smithers, B Mark; Thomson, Iain

2013-11-01

254

Concurrent Software Engineering Project  

ERIC Educational Resources Information Center

Concurrent engineering or overlapping activities is a business strategy for schedule compression on large development projects. Design parameters and tasks from every aspect of a product's development process and their interdependencies are overlapped and worked on in parallel. Concurrent engineering suffers from negative effects such as excessive…

Stankovic, Nenad; Tillo, Tammam

2009-01-01

255

Concurrent multiple target tracking  

Microsoft Academic Search

A concurrent algorithm for multiple target tracking is presented. The underlying tracking formalism is first described by way of a sequential program, and the issues in generalizing the tracker for efficient concurrent implementations are discussed in detail. Typical tracking results on the Mark III hypercube are presented.

Thomas D. Gottschalk

1988-01-01

256

36 CFR 14.56 - Concurrence by Federal Highway Administration.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Concurrence by Federal Highway Administration. 14.56 Section 14...23, U.S.C. (Interstate and Defense Highway System) § 14.56 Concurrence by Federal Highway Administration. The appropriate...

2013-07-01

257

Integration of Systemic Chemotherapy in the Management of Primary Breast Cancer  

Microsoft Academic Search

Breast cancer cells can metastasize early in the devel- opment of primary tumors. Adjuvant chemotherapy improves disease-free survival and overall survival (OS) in patients with early-stage breast cancer, both in pre- menopausal and postmenopausal women. Tamoxifen improves OS in patients whose tumors are estrogen-recep- tor-positive, regardless of age. Although the relative risk reduction with these interventions is the same for

FRANCISCO J. ESTEVA; G ABRIEL N. HORTOBAGYI

258

Dynamic programming methods for concurrent design and dynamic allocation of vehicles embedded in a system-of-systems  

Microsoft Academic Search

Recent developments indicate a changing perspective on how systems or vehicles should be designed. Such transition comes from the way decision makers in defense related agencies address complex problems. Complex problems are now often posed in terms of the capabilities desired, rather than in terms of requirements for a single systems. As a result, the way to provide a set

Nusawardhana

2007-01-01

259

RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck  

Microsoft Academic Search

Purpose: Patients with recurrent squamous cell cancer of the head and neck (SCH&N) are generally treated with systemic chemotherapy. Improvement in survival has not occurred, despite an increased objective response rate. This study was undertaken to explore the feasibility and toxicity, and estimate the therapeutic impact of, reirradiation (RRT) with concurrent hydroxyurea and 5-fluorouracil.Methods and Materials: The eligibility requirements included

S. A Spencer; J Harris; R. H Wheeler; M Machtay; C Schultz; W Spanos; M Rotman; R Meredith

2001-01-01

260

[Successful treatment of intrapericardial administration of carboplatin following systemic chemotherapy in a case of advanced thymic cancer with cardiac tamponade].  

PubMed

A 72-year-old woman developed cardiac tamponade due to direct invasion of thymic cancer. Carboplatin was administered into the pericardial cavity two times with a total dose of 600 mg. Pericardial effusion disappeared without any toxicities. Following four cycles of systemic chemotherapy by carboplatin, doxorubicin, vincristine, cyclophosphamide (ADOC), partial response was obtained. She is alive 10 month after being given a diagnosis of cardiac tamponade. Intrapericardial administration of carboplatin is a useful therapy for control of pericardial effusion and chemosensitive cases should de identified among patients with thymic cancer. PMID:17233396

Okada, Mitsuyo; Koizumi, Tomonobu; Yasuo, Masanori; Tsushima, Kenji; Urushihata, Kazuhisa; Yamaguchi, Shinji; Hanaoka, Masayuki; Fujimoto, Keisaku; Kubo, Keishi

2006-12-01

261

Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapy.  

PubMed

U.S. SEER (Surveillance Epidemiology and End Results) data for age-adjusted mortality rates for all cancers combined for all races show only a modest overall 13% decline over the past 35 years. Moreover, the greatest contributor to cancer mortality is treatment-resistant metastatic disease. The accepted therapeutic paradigm for the past half-century for the treatment of advanced cancers has involved the use of systemic chemotherapy drugs cytotoxic for cycling cells (both normal and malignant) during DNA synthesis and/or mitosis. The failure of this therapeutic modality to achieve high-level, consistent rates of disease-free survival for some of the most common cancers, including tumors of the lung, colon breast, brain, melanoma, and others is the focus of this paper. A retrospective assessment of critical milestones in cancer chemotherapy indicates that most successful therapeutic regimens use cytotoxic cell cycle inhibitors in combined, maximum tolerated, dose-dense acute treatment regimens originally developed to treat acute lymphoblastic leukemia and some lymphomas. Early clinical successes in this area led to their wholesale application to the treatment of solid tumor malignancies that, unfortunately, has not produced consistent, long-term high cure rates for many common cancers. Important differences in therapeutic sensitivity of leukemias/lymphomas versus solid tumors can be explained by key biological differences that define the treatment-resistant solid tumor phenotype. A review of these clinical outcome data in the context of recent developments in our understanding of drug resistance mechanisms characteristic of solid tumors suggests the need for a new paradigm for the treatment of chemotherapy-resistant cancers. In contrast to reductionist approaches, the systemic approach targets both microenvironmental and systemic factors that drive and sustain tumor progression. These systemic factors include dysregulated inflammatory and oxidation pathways shown to be directly implicated in the development and maintenance of the cancer phenotype. The paradigm stresses the importance of a combined preventive/therapeutic approach involving adjuvant chemotherapies that incorporate anti-inflammatory and anti-oxidant therapeutics. PMID:23805101

Crawford, Sarah

2013-01-01

262

Colonic stenosis caused by infection of an intraperitoneal access port system: a rare complication of intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis  

PubMed Central

Background Intraperitoneal (IP) chemotherapy is garnering attention as an effective treatment for gastric cancer with peritoneal metastasis. We report the case of a patient who developed colonic stenosis caused by infection of an IP access port system during IP chemotherapy. It was difficult to differentiate whether the extrinsic colonic stenosis arose from a catheter infection or peritoneal metastasis of the gastric cancer. Case presentation A 66-year-old Japanese man underwent total gastrectomy for gastric cancer. Because the intraoperative findings revealed peritoneal metastasis, a port system was implanted for subsequent IP chemotherapy. Two months after initiation of chemotherapy, he complained of vomiting and abdominal pain. A computed tomography scan revealed marked thickening of the sigmoid colon wall adjacent to the catheter of the IP access port system. A barium enema demonstrated extrinsic irregular stenosis of the sigmoid colon. Although it was difficult to distinguish whether infection or peritoneal metastasis had caused the colonic stenosis, we removed the port system to obtain a therapeutic diagnosis. Coagulase-negative staphylococci were detected by catheter culture. The wall thickening and stenosis of the sigmoid colon completely resolved after removal of the port system. Conclusions We report the case of a rare complication in association with an IP access port system. Infection of the port system should be considered as a differential diagnosis when colonic stenosis adjacent to the catheter is observed during IP chemotherapy.

2014-01-01

263

Book Reviews: The New Wave--Concurrent Programming  

Microsoft Academic Search

Until now, concurrent programming has been widely used primarily on systems that do a lot of processing - for example, Web servers. With the advent of dual-core processors, however, concurrent programming is becoming the name of the game, even for PC applications. Creating Components: Object Oriented, Concurrent, and Distributed Computing in Java by Charles W. Kann is a good reference

Milan Lathia

2006-01-01

264

Towards concrete concurrency: occam-pi on the LEGO mindstorms  

Microsoft Academic Search

In a world of ad-hoc networks, highly interconnected mobile devices and increasingly large supercomputer clusters, students need models of computation that help them think about dynamic and concurrent systems. Many of the tools currently available for introducing students to concurrency are difficult to use and are not intrinsically motivating. To provide an authentic, hands-on, and enjoyable introduction to concurrency, we

Christian L. Jacobsen; Matthew C. Jadud

2005-01-01

265

Serialization of concurrent operations in a distributed collaborative environment  

Microsoft Academic Search

In a distributed groupware system, objects shared by users are subject to concurrency and real-time constraints. In order to satisfy these, various concurrency control algorithms 141 [ 1 l] have been proposed that exploit the semantic properties of operations. By ordering concurrent operations, they guarantee consistency of the different copies of each object. The drawback of these algorithms is that

Maher Suleiman; Michèle Cart; Jean Ferrié

1997-01-01

266

Concurrence in collective models  

SciTech Connect

We review the entanglement properties in collective models and their relationship with quantum phase transitions. Focusing on the concurrence, which characterizes the two-spin entanglement, we show that for first-order transitions, this quantity is singular but continuous at the transition point, contrary to the common belief. We also propose a conjecture for the concurrence of arbitrary symmetric states which connects it with a recently proposed criterion for bipartite entanglement.

Vidal, Julien [Laboratoire de Physique Theorique de la Matiere Condensee, CNRS UMR 7600, Universite Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05 (France)

2006-06-15

267

A pilot study of an automated voice response system and nursing intervention to monitor adherence to oral chemotherapy agents.  

PubMed

This study was designed to develop and test a system to monitor adherence with nonhormonal oral chemotherapeutic agents using an automated voice response (AVR) system plus nursing intervention. Participants were patients diagnosed with solid tumor cancers, primarily breast, colon, and lung cancers, who received the Symptom Management Toolkit and participated in an interview for symptom severity, satisfaction, and beliefs about oral agents. Patients received weekly AVR calls, which assessed adherence to oral agents and severity of 15 symptoms. Patients who reported adherence of below 100% of the prescribed oral agents or symptoms of 4 or greater (0-10 scale) for 3 consecutive weeks were called by a nurse for assistance with symptom management and adherence to oral chemotherapy medications. After the 8 weekly AVR calls, patients participated in a follow-up interview and medical record review. Participants were 30 oncology patients who were ambulatory and treated at 2 cancer centers in Midwest United States. The results indicate 23.3% nonadherence rate to oral chemotherapy medications due to symptoms and forgetting to take the medication. An association between symptom management and adherence was found. Symptom severity and beliefs about medications were not significantly different between adherent and nonadherent patients. This pilot study demonstrated the ability to accrue patients for a longitudinal trial and informed intervention design while providing guidance for future interventions and research studies. PMID:19816160

Decker, Veronica; Spoelstra, Sandra; Miezo, Emily; Bremer, Renee; You, Mei; Given, Charles; Given, Barbara

2009-01-01

268

Fatal Candida septic shock during systemic chemotherapy in lung cancer patient receiving corticosteroid replacement therapy for hypopituitarism: a case report.  

PubMed

Invasive candidiasis has increased as nosocomial infection recently in cancer patients who receive systemic chemotherapy, and the timely risk assessment for developing such specific infection is crucial. Especially in those concomitantly with hypopituitarism, febrile neutropenia with candidiasis can cause severe stress and lead potentially to sudden fatal outcome when the temporal steroid coverage for the adrenal insufficiency is not fully administered. We report a 72-year-old male case diagnosed as non-small-cell lung cancer, Stage IIIA. He had received a steroid replacement therapy for the prior history of hypophysectomy due to pituitary adenoma with hydrocortisone of 3.3 mg/day, equivalent to prednisolone of 0.8 mg/day. This very small dosage of steroid was hardly supposed to weaken his immune system, but rather potentially led to an inappropriate supplementation of his adrenal function, assuming that the serum sodium and chlorine levels decreased. On Day 6 of second cycle of chemotherapy with carboplatin and paclitaxel, he developed sudden febrile neutropenia, septic shock and ileus, leading to death. After his death, the venous blood culture on Day 7 detected Candida albicans. Autopsy findings showed a massive necrotizing enterocolitis with extensive Candida invasion into submucous tissue. In conclusion, this case may suggest that (i) immediate initiation of antifungal therapy soon after the careful risk assessment of Candida infection and (ii) adequate administration of both basal steroid replacement therapy and temporal steroid coverage for febrile neutropenia might have improved his fatal outcome. PMID:24646812

Morichika, Daisuke; Sato-Hisamoto, Akiko; Hotta, Katsuyuki; Takata, Katsuyoshi; Iwaki, Noriko; Uchida, Koji; Minami, Daisuke; Kubo, Toshio; Tanimoto, Mitsune; Kiura, Katsuyuki

2014-05-01

269

Hyperthermia as Adjunct to Intravesical Chemotherapy for Bladder Cancer  

PubMed Central

Nonmuscle invasive bladder cancer remains a very costly cancer to manage because of high recurrence rates requiring long-term surveillance and treatment. Emerging evidence suggests that adjunct and concurrent use of hyperthermia with intravesical chemotherapy after transurethral resection of bladder tumor further reduces recurrence risk and progression to advanced disease. Hyperthermia has both direct and immune-mediated cytotoxic effect on tumor cells including tumor growth arrest and activation of antitumor immune system cells and pathways. Concurrent heat application also acts as a sensitizer to intravesical chemotherapy agents. As such the ability to deliver hyperthermia to the focus of tumor while minimizing damage to surrounding benign tissue is of utmost importance to optimize the benefit of hyperthermia treatment. Existing chemohyperthermia devices that allow for more localized heat delivery continue to pave the way in this effort. Current investigational methods involving heat-activated drug delivery selectively to tumor cells using temperature-sensitive liposomes also offer promising ways to improve chemohyperthermia efficacy in bladder cancer while minimizing toxicity to benign tissue. This will hopefully allow more widespread use of chemohyperthermia to all bladder cancer patients, including metastatic bladder cancer.

Owusu, Richmond A.; Abern, Michael R.; Inman, Brant A.

2013-01-01

270

Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review  

PubMed Central

Until now only intravenous and oral formulations of 5HT3 receptor antagonists have been available. Recently a new formulation of a 5HT3 receptor antagonist, transdermal granisetron, has been developed, and approved by the FDA. Three phase I studies to evaluate its pharmacokinetic profile have shown that granisetron administered by a transdermal delivery system is absorbed by passive diffusion and maximal concentration is reached 48 hours after patch application. The patch of 52 cm2, which contains 34.3 mg of granisetron, releases 3.3 mg of the drug every day and maintains a stable average plasma concentration of 2.2 ng/mL over 6 days, similar to levels obtained with 2 mg of oral granisetron, administered every day during the same period of time. Two randomized as yet unpublished clinical trials (phase II/III) have been conducted to evaluate the antiemetic efficacy of transdermal granisetron in chemotherapy-induced nausea and vomiting, in patients receiving moderately and highly emetogenic chemotherapy, compared with 2 mg of oral granisetron. More than 800 cancer patients were included in the trials. The rate of complete control of acute emesis was 49% for the phase II trial and 60% for the phase III trial. Neither trial showed a statistically significant difference between transdermal and oral granisetron. The control of delayed emesis was observed in 46% of patients, and there were no statistically significant differences between transdermal and oral granisetron. The most common adverse effects in both trials were constipation (<7%) and headache (<1%); there were no statistically significant differences between transdermal and oral granisetron. These data show that transdermal granisetron is effective and safe in controlling acute emesis induced by chemotherapy with both moderate and high emetogenic potential. Efficacy and safety of transdermal granisetron are fully comparable with that of oral granisetron. More clinical trials using regimens of 2 or 3 drugs, including dexamethasone and/or aprepitant, are needed to confirm the place of transdermal granisetron in the control of chemotherapy-induced nausea and vomiting.

Tuca, Albert

2010-01-01

271

Targeted cancer therapy--are the days of systemic chemotherapy numbered?  

PubMed

Targeted therapy or molecular targeted therapy has been defined as a type of treatment that blocks the growth of cancer cells by interfering with specific cell molecules required for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells as with traditional chemotherapy. There is a growing number of FDA approved monoclonal antibodies and small molecules targeting specific types of cancer suggestive of the growing relevance of this therapeutic approach. Targeted cancer therapies, also referred to as "Personalized Medicine", are being studied for use alone, in combination with other targeted therapies, and in combination with chemotherapy. The objective of personalized medicine is the identification of patients that would benefit from a specific treatment based on the expression of molecular markers. Examples of this approach include bevacizumab and olaparib, which have been designated as promising targeted therapies for ovarian cancer. Combinations of trastuzumab with pertuzumab, or T-DM1 and mTOR inhibitors added to an aromatase inhibitor are new therapeutic strategies for breast cancer. Although this approach has been seen as a major step in the expansion of personalized medicine, it has substantial limitations including its high cost and the presence of serious adverse effects. The Cancer Genome Atlas is a useful resource to identify novel and more effective targets, which may help to overcome the present limitations. In this review we will discuss the clinical outcome of some of these new therapies with a focus on ovarian and breast cancer. We will also discuss novel concepts in targeted therapy, the target of cancer stem cells. PMID:24128673

Joo, Won Duk; Visintin, Irene; Mor, Gil

2013-12-01

272

HIV chemotherapy  

NASA Astrophysics Data System (ADS)

The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced reductions in illness and death have been achieved and healthcare utilization has diminished. HIV therapy has also provided many new insights into the pathogenesis and the viral and cellular dynamics of HIV infection. But challenges remain. Treatment does not suppress HIV replication in all patients, and the emergence of drug-resistant virus hinders subsequent treatment. Chronic therapy can also result in toxicity. These challenges prompt the search for new drugs and new therapeutic strategies to control chronic viral replication.

Richman, Douglas D.

2001-04-01

273

Evaluation of the Efficacy of Combined Continuous Arterial Infusion and Systemic Chemotherapy for the Treatment of Advanced Pancreatic Carcinoma  

SciTech Connect

Purpose. To evaluate the effects of combined continuous transcatheter arterial infusion (CTAI) and systemic chemotherapy in patients with advanced pancreatic carcinoma. Methods. CTAI was performed in 17 patients with stage IV pancreatic cancer with (n = 11) or without (n = 6) liver metastasis. The reservoir was transcutaneously implanted with the help of angiography. The inferior pancreatic artery (IPA) was embolized to achieve delivery of the pancreatic blood supply through only the celiac artery. The systemic administration of gemcitabine was combined with the infusion of 5-fluorouracil via the reservoir. Treatment effects were evaluated based on the primary tumor size, liver metastasis, and survival time and factors such as tumor size, tumor location, and stage of pancreatic carcinoma; the embolized arteries were analyzed with respect to treatment effects and prognosis. Results. A catheter was fixed in the gastroduodenal artery and splenic artery in 10 and 7 patients, respectively. Complete peripancreatic arterial occlusion was successful in 10 patients. CT showed a decrease in tumor size in 6 of 17 (35%) patients and a decrease in liver metastases in 6 of 11 (55%) patients. The survival time ranged from 4 to 18 months (mean {+-} SD, 8.8 {+-} 1.5 months). Complete embolization of arteries surrounding the pancreas was achieved in 10 patients; they manifested superior treatment effects and prognoses (p < 0.05). Conclusion. In patients with advanced pancreatic cancer, long-term CTAI with systemic chemotherapy appeared to be effective not only against the primary tumor but also against liver metastases. Patients with successfully occluded peripancreatic arteries tended to survive longer.

Ikeda, O., E-mail: osamu-3643ik@do9.enjoy.ne.jp; Kusunoki, S.; Kudoh, K. [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, H.; Tsuji, T.; Kanemitsu, K. [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Gastroenterological Surgery (Japan); Yamashita, Y. [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan)

2006-06-15

274

Very high level concurrent programming  

SciTech Connect

The MODEL approach reported in this paper allows human designers to have a nonprocedural implementation-independent view of a concurrent system. The designers specify the problem to be solved through representing problem concepts by variables and composing equations which define the variables. They partition the overall problem into modules, which are candidates for being computed concurrently. Each module consists of a subset of the equations. Excluded are such dynamic implementation concepts as sequences of program events, synchronization, exchanges of messages and relative timing. The translation from the specification into a respective computation by an object computer architecture is performed by the language processors. The methodology supports independence in specifying and testing individual modules. The language processors detect inconsistency and incompleteness errors in both the individual modules and in the global system. The automatic implementation of a specified system is performed by the MODEL system on two levels. On the global level, the Configurator accepts as input a graph of the network of subsystems, modules, and files and their interconnections. It verifies the validity of interfaces and implements the network by generating command language programs that set up communications, optimize concurrency of modules and oversee execution of the overall system. On the local level, the Compiler accepts as input an individual module specification. It performs checking of completeness and consistency of variables and equations and generates an optimized sequential program in a high level language. The overall methodology is described through the dining philosophers which represents resource allocation, widely used in operating systems and real-time systems. Brief description of the operation of the Configurator and the Compiler are also given.

Shi, Y.; Prywes, N.; Szymanski, B.; Pnueli, A.

1987-09-01

275

Interpretive model for a ''a concurrency method''  

SciTech Connect

''A Concurrency Method'' is a language embodying the data flow characteristics of data-drive and single-assignment. The interpreter for ''A Concurrency Method'' models a physical machine with an architecture directed toward this language. The interpreter is a complete system with scheduler, editor, load balancer and message handler. This model embraces some architectural features in other data flow machines and models and combines these features in a manner most conducive to this language. 9 refs., 5 figs.

Carter, C.L.

1986-06-01

276

DREAMS and IMAGE: A Model and Computer Implementation for Concurrent, Life-Cycle Design of Complex Systems  

NASA Technical Reports Server (NTRS)

Computing architectures are being assembled that extend concurrent engineering practices by providing more efficient execution and collaboration on distributed, heterogeneous computing networks. Built on the successes of initial architectures, requirements for a next-generation design computing infrastructure can be developed. These requirements concentrate on those needed by a designer in decision-making processes from product conception to recycling and can be categorized in two areas: design process and design information management. A designer both designs and executes design processes throughout design time to achieve better product and process capabilities while expanding fewer resources. In order to accomplish this, information, or more appropriately design knowledge, needs to be adequately managed during product and process decomposition as well as recomposition. A foundation has been laid that captures these requirements in a design architecture called DREAMS (Developing Robust Engineering Analysis Models and Specifications). In addition, a computing infrastructure, called IMAGE (Intelligent Multidisciplinary Aircraft Generation Environment), is being developed that satisfies design requirements defined in DREAMS and incorporates enabling computational technologies.

Hale, Mark A.; Craig, James I.; Mistree, Farrokh; Schrage, Daniel P.

1995-01-01

277

Long-term survival in patients with newly diagnosed primary central nervous system lymphoma treated with dexamethasone, etoposide, ifosfamide and carboplatin chemotherapy and whole-brain radiation therapy.  

PubMed

In the present study, we aimed to evaluate the safety and efficacy of DeVIC (dexamethasone, etoposide, ifosfamide and carboplatin) chemotherapy for the treatment of patients with primary central nervous system lymphoma (PCNSL). We retrospectively examined 21 patients with newly diagnosed PCNSL who received DeVIC chemotherapy followed by whole-brain radiation therapy (WBRT). The median progression-free survival (PFS) in all patients was 37.4 months and the median duration of overall survival (OS) was 47.8 months. Notably, the median duration of OS was significantly longer in patients who achieved a complete response (CR) after DeVIC chemotherapy (49.0 months) than in those without CR (12.8 months). Furthermore, we found that the overall response rate to the initial DeVIC chemotherapy was 95.2%. No treatment-related deaths were observed. Our study investigated the efficacy of DeVIC chemotherapy in PCNSL patients, and found it to result in favorable survival outcomes in these patients, thus warranting further investigation of it as a therapeutic measure against PCNSL. PMID:21745167

Motomura, Kazuya; Natsume, Atsushi; Fujii, Masazumi; Ito, Motokazu; Momota, Hiroyuki; Wakabayashi, Toshihiko

2011-11-01

278

The tipping point for combination therapy: cancer vaccines with radiation, chemotherapy, or targeted small molecule inhibitors.  

PubMed

Therapeutic cancer vaccines are a unique treatment modality in that they initiate a dynamic process of activating the host immune system, which can then be exploited by concurrent or subsequent therapies. The addition of immunotherapy to standard-of-care cancer therapies has shown evidence of efficacy in preclinical models and in the clinical setting. This review examines the preclinical and clinical interactions between vaccine-mediated tumor-specific immune responses and local radiation, systemic chemotherapy, or select small molecule inhibitors, as well as the potential synergy between these modalities. PMID:22595055

Hodge, James W; Ardiani, Andressa; Farsaci, Benedetto; Kwilas, Anna R; Gameiro, Sofia R

2012-06-01

279

Concurrent Reading While Writing  

Microsoft Academic Search

The problem of asynchronous processes reading shared data while the data are being modified by another process is considered. This problem differs from the standard readers\\/writers problem in that concurrent reading while writing is allowed. The model used here strongly limits the use and size of the shared variables. If multiple copies of the shared data are allowed, then simple,

Gary L. Peterson

1983-01-01

280

Concurrent Engineering for Composites.  

National Technical Information Service (NTIS)

The Total Quality Design (TQD) approach serves as a facilitation tool for the coupled decision making that is necessary for composites. The approach serves as a means of enabling the concurrent engineering of composites through the use of a composites des...

D. J. Wilkins J. M. Henshaw V. M. Karbhari

1991-01-01

281

Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: a case report  

PubMed Central

Introduction Basaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma. Basaloid squamous cell carcinoma is mostly seen in the upper aerodigestive tract and has a propensity for lymph node spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy. To the best of our knowledge, treatment of nasal basaloid squamous cell carcinoma with proton beam therapy and cisplatin has not been described in the literature. Case presentation We report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue. He underwent proton beam therapy concurrent with cisplatin. Acute and late side effects did not exceed grade 3. At 24-month follow up, he remains in complete remission. Conclusion Proton beam therapy concurrent with cisplatin may be one choice for locally invasive basaloid squamous cell carcinoma.

2014-01-01

282

Barriers in Concurrent Separation Logic  

NASA Astrophysics Data System (ADS)

We develop and prove sound a concurrent separation logic for Pthreads-style barriers. Although Pthreads barriers are widely used in systems, and separation logic is widely used for verification, there has not been any effort to combine the two. Unlike locks and critical sections, Pthreads barriers enable simultaneous resource redistribution between multiple threads and are inherently stateful, leading to significant complications in the design of the logic and its soundness proof. We show how our logic can be applied to a specific example program in a modular way. Our proofs are machine-checked in Coq.

Hobor, Aquinas; Gherghina, Cristian

283

Concurrent engineering: success stories in instrumentation, communications  

Microsoft Academic Search

Four case histories of the successful use of concurrent engineering (CE) to develop instrumentation and communications products are presented. They are the development of an oscilloscope at Hewlett-Packard, the development of internetworking products by Cisco Systems, large-scale systems development at Raytheon, and making one-of-a-kind products at ITEK optical systems.

R. Wheeler; R. W. Burnett; A. Rosenblatt

1991-01-01

284

Tumor Specific Gene Expression and Tumor Specific Vector Replication for Systemic Chemotherapy Sensitization Treatment of Breast Cancer.  

National Technical Information Service (NTIS)

Once breast cancer recurs after initial surgery or radiation therapy and is found to be incompletely responsive to salvage chemotherapy, there is no established treatment that can prolong survival. To address this problem, the Deisseroth laboratory has de...

A. B. Deisseroth

2002-01-01

285

3D Radiotherapy Can Be Safely Combined With Sandwich Systemic Gemcitabine Chemotherapy in the Management of Pancreatic Cancer: Factors Influencing Outcome  

SciTech Connect

Purpose: The aim of this Phase II study was to examine whether concurrent continuous infusion 5-fluorouracil (CI 5FU) plus three-dimensional conformal planning radiotherapy sandwiched between gemcitabine chemotherapy is effective, tolerable, and safe in the management of pancreatic cancer. Methods and Materials: Patients were enrolled in two strata: (1) resected pancreatic cancer at high risk of local relapse (postsurgery arm, n = 22) or (2) inoperable pancreatic cancer in head or body without metastases (locally advanced arm, n = 41). Gemcitabine was given at 1,000 mg/m{sup 2} weekly for 3 weeks followed by 1 week rest then 5-6 weeks of radiotherapy and concurrent CI 5FU (200 mg/m{sup 2}/day). After 4 weeks' rest, gemcitabine treatment was reinitiated for 12 weeks. Results: For the two arms combined, treatment-related Grade 3 and 4 toxicities were reported by 25 (39.7%) and 7 (11.1%) patients, respectively. No significant late renal or hepatic toxicity was observed. In the postsurgery arm (R1 54.5%), median time to progressive disease from surgery was 11.0 months, median time to failure of local control was 32.9 months, and median survival time was 15.6 months. The 1- and 2-year survival rates were 63.6% and 31.8%. No significant associations between outcome and mutations in K-ras or TP53 or microsatellite instability were identified. Post hoc investigation of cancer antigen 19-9 levels found baseline levels and increases postbaseline were associated with shorter survival (p = 0.0061 and p < 0.0001, respectively). Conclusions: This three-dimensional chemoradiotherapy regimen is safe and promising, with encouraging local control for a substantial proportion of patients, and merits testing in a randomized trial.

Spry, Nigel [Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA (Australia)], E-mail: Nigel.Spry@health.wa.gov.au; Harvey, Jennifer [Department of Radiation Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland (Australia); MacLeod, Craig [Department of Radiation Oncology, Murray Valley Private Hospital, Wodonga, Victoria (Australia); Borg, Martin [Adelaide Radiotherapy Centre, Adelaide, SA (Australia); Ngan, Samuel Y. [Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Millar, Jeremy L. [Department of Radiation Oncology, The Alfred, Prahran, Victoria (Australia); Graham, Peter [Department of Radiation Oncology, St. George Hospital, Kogarah, NSW (Australia); Zissiadis, Yvonne [Department of Radiation Oncology, Royal Perth Hospital, Perth, WA (Australia); Kneebone, Andrew [Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW (Australia); Carroll, Susan [Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW (Australia); Davies, Terri; Reece, William H.H. [Eli Lilly Australia, West Ryde, NSW (Australia); Iacopetta, Barry [School of Surgery and Pathology, University of Western Australia, Nedlands, WA (Australia); Goldstein, David [Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW (Australia)

2008-04-01

286

Concurrent Operations in a Distributed and Mobile Collaborative Environment  

Microsoft Academic Search

In a distributed groupware system, objects shared by users are subject to concurrency and real time constraints. In order to satisfy these, various concurrency control algorithms have been proposed that exploit the semantic properties of operations (C.A. Ellis and S.J. Gibbs, 1989; A. Karsenty and M. Beaudouin-Lafon, 1993; C. Sun et al., 1996). By ordering concurrent operations, they generally guarantee

Maher Suleiman; Michèle Cart; Jean Ferrié

1998-01-01

287

Malaria Parasitemia Associated with Febrile Neutropenia in African Patients Undergoing Chemotherapy for Haematological Malignancies  

Microsoft Academic Search

Background: Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. Methods: This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemotherapy who developed febrile neutropenia and malaria parasitemia concurrently. Results: Three patients infected with documented malaria during a febrile

Bernardo L. Rapoport; Almarie Uys

2008-01-01

288

Multi-targeting cancer chemotherapy using temperature-responsive drug carrier systems  

Microsoft Academic Search

Recently, a growing number of nano-scale drug carrier systems (e.g., drug–polymer conjugates, liposomes, and polymeric micelles) attract great attention for targeting cancer therapy due to a passively selective accumulation at solid tumor tissues and a subsequent anti-cancer activity. However, for the present drug targeting carrier systems, the target-selective delivery and release of loaded drugs are incapable to control completely. To

Masamichi Nakayama; Teruo Okano

2011-01-01

289

Data Flow Analysis for Checking Properties of Concurrent Java Programs  

Microsoft Academic Search

ABSTRACT In this paper we show how the FLAVERS data flow anal - ysis technique, originally formulated for systems using a rendezvous concurrency model, can be applied to the vari - ous concurrency models used in Java programs The gen - eral approach of FLAVERS is based on modeling a concur - rent system as a flow graph and, using

George S. Avrunin; Gleb Naumovich; Lori A. Clarke

1998-01-01

290

A System for Concurrently Delivering a Stream of Powdered Fuel and a Stream of Powdered Oxidizer to a Combustion Chamber for a Reaction Motor.  

National Technical Information Service (NTIS)

A propellant delivery subsystem adapted to concurrently supply streams of powdered fuel and fluidized oxidizer includes one reservoir for powdered fuel and a second for powdered oxidizer. The particle size for the powdered fuel and powdered oxidizer is su...

L. M. Delionback R. M. Stein

1978-01-01

291

Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma  

Microsoft Academic Search

The purpose of this study is to evaluate the efficacy and toxicity of radiation therapy (RT) with concurrent temozolomide\\u000a (TMZ) chemotherapy followed by adjuvant TMZ in children with diffuse intrinsic pontine glioma (DIPG). Newly diagnosed patients\\u000a younger than 18 years with histologically proven DIPG were treated with focal radiotherapy to a dose of 54 Gy in 30 fractions\\u000a along with concurrent daily

Andrea Chassot; Sandra Canale; Pascale Varlet; Stephanie Puget; Thomas Roujeau; Laura Negretti; Frederic Dhermain; Xavier Rialland; Marie Anne Raquin; Jacques Grill; Christelle Dufour

292

Management of chemotherapy-induced peripheral neuropathy  

Microsoft Academic Search

Recent advances in the development and administration of chemotherapy for malignant diseases have been rewarded with prolonged\\u000a survival rates. The cost of progress has come at a price and the nervous system is frequently the target of chemotherapy-induced\\u000a neurotoxicity. Unlike more immediate toxicities that effect the gastrointestinal tract and bone marrow, chemotherapy-induced\\u000a neurotoxicity is frequently delayed in onset and may

Mark Stillman; Juan P. Cata

2006-01-01

293

Development of concept for concurrent biocide generation and water system purification. [with application to Skylab water tanks  

NASA Technical Reports Server (NTRS)

An attempt was made to construct an electrochemical system, using iodine, for water purification in Skylab. Data cover measurements of iodine production rates, effect of electrode size and geometry on iodine production rates, and feasibility of using stainless steels as reference electrodes.

1974-01-01

294

A Hybrid Model for Optimal Concurrent Design of Solid Oxide Fuel Cell System Considering Functional Performance and Production Cost  

Microsoft Academic Search

This research addresses the issues to identify the optimal design of solid oxide fuel cell (SOFC) system considering functional performance and production cost. In this research, modeling of the relations between design parameters and evaluation parameters is first discussed. Due to uncertainties of parameter relations, a hybrid model is introduced in this work to describe two types of parameter relations,

Dong Zhao; Wei Dong; Deyi Xue

2008-01-01

295

Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy  

SciTech Connect

Purpose: To identify dosimetric parameters associated with acute hematologic toxicity (HT) and chemotherapy delivery in cervical cancer patients undergoing concurrent chemotherapy and intensity-modulated pelvic radiotherapy. Methods and Materials: We analyzed 37 cervical cancer patients receiving concurrent cisplatin (40 mg/m{sup 2}/wk) and intensity-modulated pelvic radiotherapy. Pelvic bone marrow (BM) was contoured for each patient and divided into three subsites: lumbosacral spine, ilium, and lower pelvis. The volume of each region receiving 10, 20, 30, and {>=}40 Gy (V{sub 1}, V{sub 2}, V{sub 3}, and V{sub 4}, respectively) was calculated. HT was graded according to Radiation Therapy Oncology Group system. Multivariate regression models were used to test associations between dosimetric parameters and HT and chemotherapy delivery. Results: Increased pelvic BM V{sub 1} (BM-V{sub 1}) was associated with an increased Grade 2 or worse leukopenia and neutropenia (odds ratio [OR], 2.09; 95% confidence interval [CI], 1.24-3.53; p = 0.006; and OR, 1.41; 95% CI, 1.02-1.94; p = 0.037, respectively). Patients with BM-V{sub 1} {>=}90% had higher rates of Grade 2 or worse leukopenia and neutropenia than did patients with BM-V{sub 1} <90% (11.1% vs. 73.7%, p < 0.01; and 5.6% vs. 31.6%, p = 0.09) and were more likely to have chemotherapy held on univariate (16.7% vs. 47.4%, p = 0.08) and multivariate (OR, 32.2; 95% CI, 1.67-622; p = 0.02) analysis. No associations between HT and V{sub 3} and V{sub 4} were observed. Dosimetric parameters involving the lumbosacral spine and lower pelvis had stronger associations with HT than did those involving the ilium. Conclusion: The volume of pelvic BM receiving low-dose radiation is associated with HT and chemotherapy delivery in cervical cancer patients undergoing concurrent chemoradiotherapy.

Mell, Loren K. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States) and Department of Radiation and Cellular Oncology, University of Illinois at Chicago, Chicago, IL (United States)]. E-mail: lmell@radonc.uchicago.edu; Kochanski, Joel D. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Department of Radiation and Cellular Oncology, University of Illinois at Chicago, Chicago, IL (United States); Roeske, John C. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Department of Radiation and Cellular Oncology, University of Illinois at Chicago, Chicago, IL (United States); Haslam, Josh J. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Department of Radiation and Cellular Oncology, University of Illinois at Chicago, Chicago, IL (United States); Mehta, Neil [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Department of Radiation and Cellular Oncology, University of Illinois at Chicago, Chicago, IL (United States); Yamada, S. Diane [Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Hurteau, Jean A.; Collins, Yvonne C. [Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Illinois at Chicago, Chicago, IL (United States); Lengyel, Ernst [Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Mundt, Arno J. [Department of Radiation Oncology, University of California, San Diego, School of Medicine, La Jolla, CA (United States)

2006-12-01

296

[A case of bladder cancer producing granulocyte colony-stimulating factor and interleukin-6 causing respiratory failure treated with neoadjuvant systemic chemotherapy along with sivelestat].  

PubMed

A 67-year-old man visited an urological clinic with a chief complaint of urination pain. Cystourethroscopy and magnetic resonance imaging (MRI) examination revealed a bladder tumor (cT3bN0M0). Marked leukocytosis and respiratory distress with pleural effusion appeared. Pulse steroid therapy improved the general condition partially. The patient was sent to our hospital for further examination. Serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) were high and the pathological findings of bladder tumor obtained by transurethral resection (TUR) revealed an urothelial carcinoma that produced G-CSF and IL-6. Neoadjuvant systemic chemotherapy was performed along with use of steroid and sivelestat, which ameliorated the respiratory distress. After three courses of systemic chemotherapy, serum G-CSF and IL-6 normalized and cystoprostatectomy was performed. The patient has been in good health at 20 months after the surgery with no evidence of recurrence. PMID:23945326

Matsuzaki, Kyosuke; Okumi, Masayoshi; Kishimoto, Nozomu; Yazawa, Koji; Miyagawa, Yasushi; Uchida, Kinya; Nonomura, Norio

2013-07-01

297

Virchow lymph node metastatic recurrence of sigmoid colon cancer with severe lymph node metastases successfully treated using systemic chemotherapy combined with radiotherapy.  

PubMed

Metastatic recurrence of colon cancer in the left supraclavicular lymph node (Virchow lymph node) is rare, and to date there are no reports on radiotherapy as treatment. We report on a case of metastatic recurrence of sigmoid colon cancer in the Virchow lymph node with severe lymph node metastases successfully treated with a combined modality therapy of systemic chemotherapy and radiotherapy. The case is of a 58-year-old man, who underwent sigmoid excision and lymph node excision, and subsequently received systemic chemotherapy. After left supraclavicular lymph node recurrence appeared he later received radiotherapy. Complete response was achieved, and there has been no further recurrence, to date, 10 months after the radiotherapy. Radiotherapy was effective as a local treatment, and local control of distant metastasis of colonic cancer may lead to a good prognosis. PMID:23780983

Ohchi, Takafumi; Akagi, Yoshito; Kinugasa, Tetsushi; Ishibashi, Yoshiaki; Tanaka, Natsuki; Fujino, Shinya; Kibe, Shiro; Yuge, Kotaro; Sasatomi, Teruo; Mizobe, Tomoaki; Oka, Yosuke; Hong, Kawang Dae; Shirouzu, Kazuo

2013-07-01

298

[Systemic treatment of brain metastases from breast cancer: cytotoxic chemotherapy and targeted therapies].  

PubMed

Prevalence of brain metastases is increasing in breast cancer. Brain metastases represent a poor-prognosis disease for which local treatments continue to play a major role. In spite of the presence of a physiological blood-brain barrier limiting their activity, some systemic treatments may display a significant antitumor activity at the central nervous system level. In HER2-positive metastatic breast cancer with brain metastases not previously treated with whole brain radiotherapy, capecitabine and lapatinib combination obtains a volumetric reponse in two thirds of patients (LANDSCAPE study). If confirmed, these results could modify in selected patients the layout of therapeutic strategies. Promoting novel targeted approaches and innovative therapeutic combinations is a critical need to improve survival of breast cancer patients with brain metastases. PMID:23305997

Bachelot, Thomas; Le Rhun, Emilie; Labidi-Gally, Intidar; Heudel, Pierre; Gilabert, Marine; Bonneterre, Jacques; Pierga, Jean-Yves; Gonçalves, Anthony

2013-01-01

299

Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals  

DOEpatents

A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

Gardner, Shea Nicole (San Leandro, CA)

2007-10-23

300

Multidisciplinary Concurrent Design Optimization via the Internet  

NASA Technical Reports Server (NTRS)

A methodology is presented which uses commercial design and analysis software and the Internet to perform concurrent multidisciplinary optimization. The methodology provides a means to develop multidisciplinary designs without requiring that all software be accessible from the same local network. The procedures are amenable to design and development teams whose members, expertise and respective software are not geographically located together. This methodology facilitates multidisciplinary teams working concurrently on a design problem of common interest. Partition of design software to different machines allows each constituent software to be used on the machine that provides the most economy and efficiency. The methodology is demonstrated on the concurrent design of a spacecraft structure and attitude control system. Results are compared to those derived from performing the design with an autonomous FORTRAN program.

Woodard, Stanley E.; Kelkar, Atul G.; Koganti, Gopichand

2001-01-01

301

Paradoxical progression of tuberculous lesions during chemotherapy of central nervous system tuberculosis. Report of four cases.  

PubMed

The peculiar phenomenon of paradoxical progression during the treatment of central nervous system tuberculosis is discussed. A few cases with this phenomenon were reported in the past, and the authors have treated four such cases. During the treatment for tuberculous meningitis, the four patients developed new lesions, mainly in the form of tuberculomas, which progressed for some time and later regressed. In all these cases the initial drug regimen was not changed, except for the addition of steroids for a short period at the time of deterioration. All four patients underwent ventriculoperitoneal shunt insertion during the course of treatment. The authors discuss the significance of the changes in the lesions and management of such cases, and review the literature. PMID:7616286

Rao, G P; Nadh, B R; Hemaratnan, A; Srinivas, T V; Reddy, P K

1995-08-01

302

Chemotherapy and Pregnancy  

MedlinePLUS

... you. I had chemotherapy as a child. I am now pregnant. Will my previous exposure to these ... specific treatment. If I undergo chemotherapy while I am pregnant, can it have delayed adverse effects on ...

303

Enhancement of Aerosol Cisplatin Chemotherapy with Gene Therapy Expressing ABC10 protein in Respiratory System  

PubMed Central

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. We included the following groups to our work: a) control, b) aerosol vector, c) aerosol vector plus cisplatin, d) aerosol cisplatin, e) intratumoral cisplatin administration, f) intratumoral vector plus cisplatin administration. The results indicate that the aerosol cisplatin group had a long term survival with the intratumoral cisplatin group following. The enhancement of the ABCA family locally to the respiratory system prior to the aerosol cisplatin administration can be used safely and efficiently. Future treatment design of local therapies should include the investigation of local transporters and genes.

Hohenforst-Schmidt, Wolfgang; Zarogoulidis, Paul; Linsmeier, Bernd; Kioumis, Ioannis; Li, Qiang; Huang, Haidong; Sachpatzidou, Despoina; Lampaki, Sofia; Organtzis, John; Domvri, Kalliopi; Sakkas, Leonidas; Zachariadis, George A.; Archontas, Konstantinos N.; Kallianos, Anastasios; Rapti, Aggeliki; Yarmus, Lonny; Zarogoulidis, Konstantinos; Brachmann, Johannes

2014-01-01

304

Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria  

PubMed Central

SUMMARY Despite the overlapping distribution of Schistosoma haematobium and Plasmodium falciparum infections, few studies have investigated early immune responses to both parasites in young children resident in areas co-endemic for the parasites. This study measures infection levels of both parasites and relates them to exposure and immune responses in young children. Levels of IgM, IgE, IgG4 directed against schistosome cercariae, egg and adult worm and IgM, IgG directed against P. falciparum schizonts and the merozoite surface proteins 1 and 2 together with the cytokines IFN-?, IL-4, IL-5, IL-10 and TNF-? were measured by ELISA in 95 Zimbabwean children aged 1–5 years. Schistosome infection prevalence was 14·7% and that of Plasmodium infection was 0% in the children. 43. 4% of the children showed immunological evidence of exposure to schistosome parasites and 13% showed immunological evidence of exposure to Plasmodium parasites. Schistosome–specific responses, indicative of exposure to parasite antigens, were positively associated with cercariae-specific IgE responses, while Plasmodium-specific responses, indicative of exposure to parasite antigens, were negatively associated with responses associated with protective immunity against Plasmodium. There was no significant association between schistosome-specific and Plasmodium-specific responses. Systemic cytokine levels rose with age as well as with schistosome infection and exposure. Overall the results show that (1) significantly more children are exposed to schistosome and Plasmodium infection than those currently infected and; (2) the development of protective acquired immunity commences in early childhood, although its effects on infection levels and pathology may take many years to become apparent.

IMAI, NATSUKO; RUJENI, NADINE; NAUSCH, NORMAN; BOURKE, CLAIRE D.; APPLEBY, LAURA J.; COWAN, GRAEME; GWISAI, REGGIS; MIDZI, NICHOLAS; CAVANAGH, DAVID; MDULUZA, TAKAFIRA; TAYLOR, DAVID; MUTAPI, FRANCISCA

2011-01-01

305

Concurrent C++: Concurrent Programming with Class(es)  

Microsoft Academic Search

ion and Concurrent ProgrammingAll the advantages of using data abstraction facilities for sequential programming also apply to concurrentprogramming. Specifically, with regard to concurrent programming, data abstraction facilities can providea better, higher-level and more robust interface for the services provided by one or more processes. Classescan be used to ensure that the protocol for interacting with a process is properly observed

Narain H. Gehani; William D. Roome

1988-01-01

306

Bufalin loaded biotinylated chitosan nanoparticles: An efficient drug delivery system for targeted chemotherapy against breast carcinoma.  

PubMed

Bufalin is a traditional oriental medicine which is known to induce apoptosis in many tumor cells, and it is thus considered as a new anticancer therapeutic. By now, most of the studies of bufalin are in vitro, however in vivo evaluations of its therapeutic efficacy are less and are in great demand for its development toward anticancer drug. One of the problems probably hampering the development of bufalin is the lack of tumor selectivity, which may reduce the therapeutic effect as well as showing side effects. To overcome this drawback, in this study, we designed a tumor-targeted drug delivery system of bufalin based on enhanced permeability and retention (EPR) effect, by using biotinylated chitosan, resulting in bufalin encapsulating nanoparticles (Bu-BCS-NPs) with mean hydrodynamic size of 171.6nm, as evidenced by dynamic light scattering and transmission electron microscope. Bu-BCS-NPs showed a relative slow and almost linear release of bufalin, and about 36.8% of bufalin was released in 24h when dissolved in sodium phosphate buffer. Compared to native bufalin, Bu-BCS-NPs exhibited a stronger cytotoxicity against breast cancer MCF-7 cells (IC50 of 0.582?g/ml vs 1.896?g/ml of native bufalin). Similar results were also obtained in intracellular reactive oxygen species production, apoptosis induction, and decrease in mitochondria membrane potential. These results may contribute to the rapid intracellular uptake of nanoparticles, partly benefiting from the highly expressed biotin receptors in tumor cells. In vivo studies using MCF-7 tumor models in nude mice confirmed the remarkable therapeutic effect of Bu-BCS-NPs. These findings suggest the potential of Bu-BCS-NPs as an anticancer drug with tumor targeting property. PMID:24846793

Tian, Xin; Yin, Hongzhuan; Zhang, Shichen; Luo, Ying; Xu, Kai; Ma, Ping; Sui, Chengguang; Meng, Fandong; Liu, Yunpeng; Jiang, Youhong; Fang, Jun

2014-08-01

307

Intraarterial Chemotherapy or Chemoembolization for Locally Advanced and/or Recurrent Hepatic Tumors: Evaluation of the Feeding Artery with an Interventional CT System  

SciTech Connect

Purpose: To evaluate the utility of an interventional CT system for intraarterial chemotherapy or chemoembolization for locally advanced and/or recurrent hepatic tumors.Methods: Thirty-eight patients with locally advanced or recurrent hepatic tumors underwent 73 intraarterial contrast-enhanced CT (IA-CECT) examinations immediately before chemotherapy or chemoembolization. The degree of tumor vascularity on angiography and enhancement on IA-CECT was classified into three grades: no, mild, or marked vascularity. The IA-CECT grades were compared with the angiographic grades.Results: Twenty-nine (69%) of 42 examinations that were interpreted as having no or mild vascularity on angiography were classified as marked enhancement on IA-CECT. Based on IA-CECT findings, the position of the catheter was changed in 14 (19%) of 73 CT examinations. The reasons for the reposition were as follows: weak or no enhancement of the tumor (n = 11) or strong enhancement of the gallbladder wall (n = 3). The treatment strategy was changed in three patients (8%). No major complications relating to the interventional procedures were observed.Conclusions: IA-CECT is a reliable method when evaluating the perfusion of the tumor and adjacent normal tissues. The interventional CT system is useful for performing safe and effective intraarterial chemotherapy or chemoembolization in patients with locally advanced and/or recurrent hepatic tumors.

Hirai, Toshinori [Department of Radiology, Amakusa Medical Center, 854-1 Kameba, Hondo, Kumamoto 863-0046 (Japan); Korogi, Yukunori [Department of Radiology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556 (Japan); Ono, Ken; Maruoka, Kousei [Department of Radiology, Amakusa Medical Center, 854-1 Kameba, Hondo, Kumamoto 863-0046 (Japan); Harada, Kazunori [Department of Surgery, Amakusa Medical Center, 854-1 Kameba, Hondo, Kumamoto 863-0046 (Japan); Aridomi, Satoshi [Department of Internal Medicine, Amakusa Medical Center, 854-1 Kameba, Hondo, Kumamoto 863-0046 (Japan); Takahashi, Mutsumasa [Department of Radiology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556 (Japan)

2001-05-15

308

Long-Term Follow-Up of Dose-Adapted and Reduced-Field Radiotherapy With or Without Chemotherapy for Central Nervous System Germinoma  

SciTech Connect

Purpose: To update our institutional experience with neoadjuvant chemotherapy and minimized radiotherapy vs. radiation monotherapy for intracranial germinoma. Methods and Materials: We retrospectively reviewed records of 59 patients with diagnosis of primary intracranial germinoma between 1977 and 2007. Treatment was irradiation alone or neoadjuvant platinum-based chemotherapy and local irradiation (initial tumor plus margin) for patients with localized complete response and reduced-dose craniospinal irradiation for others. Results: For the chemoradiotherapy group (n = 28), median follow-up was 7 years. No patient died. The freedom from progression (FFP) rate was 88% at 5 years and 80% at 10 years. In 4 patients, disease recurred 1.1 to 6.8 years after diagnosis. All were young male patients who received 30.6 Gy to local fields after complete response to chemotherapy. The FFP rate was 88% for local irradiation vs. 100% for more extensive fields (p = .06). For the radiotherapy-alone group (n = 31), median follow-up was 15 years. Overall and disease-free survival rates were 93% and 93% at 5 years and 90% and 87% at 15 years. In 5 patients, disease recurred 1.1 to 4.9 years after diagnosis. Most patients in this group were young men 18 to 23 years of age with suprasellar primary disease treated with about 50 Gy to local fields. The FFP rate was 44% for local irradiation vs. 100% for more extensive fields (p < .01). Conclusions: The addition of neoadjuvant chemotherapy to local-field radiotherapy reduced central nervous system cancer recurrence when high-risk patients were excluded by thorough pretreatment staging. There was trend toward improved central nervous system tumor control when larger fields (whole brain, whole ventricle, or craniospinal axis) were used.

Jensen, Ashley W. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Issa Laack, Nadia N., E-mail: laack.nadia@mayo.ed [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Buckner, Jan C. [Department of Oncology, Mayo Clinic, Rochester, MN (United States); Schomberg, Paula J. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Wetmore, Cynthia J. [Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN (United States); Brown, Paul D. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)

2010-08-01

309

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine  

PubMed Central

Our understanding of the mitochondrial or intrinsic apoptosis pathway and its role in chemotherapy resistance has increased significantly in recent years by a combination of experimental studies and mathematical modelling. This combined approach enhanced the quantitative and kinetic understanding of apoptosis signal transduction, but also provided new insights that systems-emanating functions (i.e., functions that cannot be attributed to individual network components but that are instead established by multi-component interplay) are crucial determinants of cell fate decisions. Among these features are molecular thresholds, cooperative protein functions, feedback loops and functional redundancies that provide systems robustness, and signalling topologies that allow ultrasensitivity or switch-like responses. The successful development of kinetic systems models that recapitulate biological signal transduction observed in living cells have now led to the first translational studies, which have exploited and validated such models in a clinical context. Bottom-up strategies that use pathway models in combination with higher-level modelling at the tissue, organ and whole body-level therefore carry great potential to eventually deliver a new generation of systems-based diagnostic tools that may contribute to the development of personalised and predictive medicine approaches. Here we review major achievements in the systems biology of intrinsic apoptosis signalling, discuss challenges for further model development, perspectives for higher-level integration of apoptosis models and finally discuss requirements for the development of systems medical solutions in the coming years.

Wurstle, M L; Zink, E; Prehn, J H M; Rehm, M

2014-01-01

310

Supportive care considerations during concurrent chemoradiotherapy for pancreatic adenocarcinoma: lessons learned from clinical experience.  

PubMed

Concurrent chemotherapy and radiotherapy (chemoradiotherapy) for the management of pancreatic adenocarcinoma in either adjuvant or locally regional advanced settings produces predictable acute toxicities that are proportional in severity to the intensity and type of systemic therapy and to the parameters of radiotherapy. In addition, relevant to the adjuvant setting, surgery for pancreatic cancer often produces physiologic alterations that may impact a patient's ability to tolerate chemoradiotherapy. Failures to anticipate, monitor, and proactively manage the effects of surgery and toxicities of chemoradiotherapy can result in the need for unplanned treatment interruptions and/or inability to complete all planned therapy. In this review, complications of pancreatic cancer itself and of pancreatic resection as well as toxicities of chemoradiotherapy are delineated, and approaches to their management before, during, and after chemoradiotherapy are presented. Planning for the treatment of side effects before the anticancer therapy begins facilitates therapy administration and improves patient tolerance. PMID:22237148

Wang-Gillam, Andrea; Abrams, Ross A; Posner, Mitchell C; Pisters, Peter W T; Picozzi, Vincent J

2013-12-01

311

Neoadjuvant chemotherapy for gastric cancer: Update  

Microsoft Academic Search

Neoadjuvant chemotherapy has recently received increasing attention in an attempt to increase the rate of complete tumor resections, combat systemic metastases, and prolong survival in patients with gastric cancer. The available data indicate that neoadjuvant chemotherapy is feasible and does not increase postoperative morbidity and mortality. Compared to the results that can today be obtained with primary resection and lymphadenectomy,

U. Fink; H. J. Stein; C. Schuhmacher; H. J. Wilke

1995-01-01

312

SCOOP: Concurrent Programming Made Easy  

Microsoft Academic Search

The SCOOP model (Simple Concurrent Object-Oriented Programming) provides a simple yet very powerful mechanism for parallel computation. The model takes advantage of the inherent concurrency implicit in object-oriented programming to provide programmers with a simple extension enabling them to produce parallel applications with little more effort than sequential ones. SCOOP is applicable to many different physical setups, from multiprocessing to

Piotr Nienaltowski; Volkan Arslan; Bertrand Meyer

313

Concurrent Prolog: A progress report  

Microsoft Academic Search

Concurrent Prolog is a logic programming language designed for concurrent programming and parallel execution. A process-oriented language, it embodies dataflow synchronization and guarded-command indeterminacy as its basic control mechanism. This article outlines the basic concepts and definition of the language, and surveys the major programming techniques that emerged out of three years of its use. The history of the language

E. Shapiro

1986-01-01

314

Concurrent Planning: Benefits and Pitfalls.  

ERIC Educational Resources Information Center

Examines the benefits and pitfalls of large-scale concurrent planning--working with families toward reunification while developing alternative permanency plans. Notes that as large-scale programs begin to develop nationally, those implementing concurrent planning must be aware of pitfalls that can undermine effectiveness, while keeping in mind its…

Katz, Linda

1999-01-01

315

Effectiveness of concurrent radiation therapy with UFT or TS-1 for T2N0 glottic cancer in Japan.  

PubMed

The aim of this retrospective study was to compare concurrent radiation therapy (RT) combined with peroral chemotherapy (UFT or TS-1) with conventional RT for T2N0 glottic cancer. Between 1974 and 2005, 153 patients with T2N0 glottic cancer were treated with radiation alone or radiation combined with peroral (UFT or TS-1) or intravenous chemotherapy. All except one patient were treated with 2 Gy per fraction, 5 fractions per week, totaling 60 Gy; and the remaining patient was treated with 1.8 Gy per fraction, 5 fractions per week, totaling 61.2 Gy. Eighty-three patients were concurrently given UFT, 24 were given TS-1, 23 intravenous chemotherapy (mainly cisplatin; the Pt Group), and 23 had no chemotherapy. The 5-year local control rate was 83.4%. Stratified by RT alone (the RT group) and concurrent chemoradiation therapy (the CCRT group), 5-year local control rates of the RT and CCRT groups were 82.7% and 83.4%, respectively (p=NS). Stratified by chemotherapy regimens of the CCRT group, 3-year local control rates of the UFT, TS-1 and Pt groups were 90.1%, 100.0% and 73.4%, respectively. Concurrent chemoradiation therapy using UFT or TS-1 for T2N0 glottic cancer is one of the standard treatments in Japan. Concurrent use of TS-1 could be a breakthrough treatment for T2N0 glottic cancer. PMID:17972507

Niibe, Yuzuru; Nakayama, Meijin; Matsubayashi, Takashi; Takahashi, Hiroomi; Kitano, Masahi; Okamoto, Makito; Hayakawa, Kazushige

2007-01-01

316

Thalidomide Combined with Neoadjuvant Chemotherapy in Angiosarcoma of the Breast with Complete Pathologic Response: Case Report and Review of Literature  

PubMed Central

Summary Background Primary angiosarcoma of the breast is a rare malignancy. Case Report We report on a 41-year-old female patient who initially presented with locally advanced disease. Core biopsy showed angiosarcoma of the breast, grade 1, CD31-positive. The patient was treated with neoadjuvant systemic chemotherapy based on cisplatin, doxorubicin, and paclitaxel, given concurrently with thalidomide. After treatment completion, the patient underwent radical mastectomy. Pathologic complete response in the breast and axillary lymph nodes was achieved. The patient has no evidence of disease recurrence 6 months after her initial diagnosis. Conclusion Anti-angiogenic therapy may be considered as part of the management of primary angiosarcoma of the breast.

Alvarado-Miranda, Alberto; Bacon-Fonseca, Ludwing; Ulises Lara-Medina, Fernando; Maldonado-Martinez, Hector; Arce-Salinas, Claudia

2013-01-01

317

Metronomics: towards personalized chemotherapy?  

PubMed

Since its inception in 2000, metronomic chemotherapy has undergone major advances as an antiangiogenic therapy. The discovery of the pro-immune properties of chemotherapy and its direct effects on cancer cells has established the intrinsic multitargeted nature of this therapeutic approach. The past 10 years have seen a marked rise in clinical trials of metronomic chemotherapy, and it is increasingly combined in the clinic with conventional treatments, such as maximum-tolerated dose chemotherapy and radiotherapy, as well as with novel therapeutic strategies, such as drug repositioning, targeted agents and immunotherapy. We review the latest advances in understanding the complex mechanisms of action of metronomic chemotherapy, and the recently identified factors associated with disease resistance. We comprehensively discuss the latest clinical data obtained from studies performed in both adult and paediatric populations, and highlight ongoing clinical trials. In this Review, we foresee the future developments of metronomic chemotherapy and specifically its potential role in the era of personalized medicine. PMID:24913374

André, Nicolas; Carré, Manon; Pasquier, Eddy

2014-07-01

318

Intensive chemotherapy with thiotepa, busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases  

PubMed Central

Background Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a large multicenter retrospective analysis of intensive chemotherapy followed by hematopoietic stem cell rescue in immunocompetent adult patients with primary central nervous system lymphoma or intraocular lymphoma after the failure of high-dose methotrexate-based treatment. Design and Methods Patients were included if they received intensive chemotherapy with a combination of thiotepa, busulfan and cyclophosphamide. Seventy-nine patients (median age 52.4 years, range 23-67 years) were identified. All of the patients except 5 received a salvage treatment after the failure of high-dose methotrexate. After salvage treatment and just before intensive chemotherapy followed by hematopoietic stem cell rescue, 32 patients were in complete response, 26 patients were in partial response, 2 patients had stable disease and 19 patients had progressive disease. Results With a median follow up of 56 months, the 5-year overall survival probability was 51% in the whole population and 62% among patients who were chemosensitive to the salvage treatment. The 5-year event-free survival probability was 37.8% in the whole population and 43.7% in the chemosensitive subpopulation. Neurocognitive assessments in a subset of patients suggest no evidence of intensive chemotherapy-induced neurocognitive decline. Conclusions Thiotepa, busulfan and cyclophosphamide-based intensive chemotherapy is an effective treatment for refractory and recurrent primary central nervous system lymphoma in chemosensitive patients up to 65 years of age. The role of intensive chemotherapy followed by hematopoietic stem cell rescue in chemorefractory patients needs to be more accurately defined.

Soussain, Carole; Choquet, Sylvain; Fourme, Emmanuelle; Delgadillo, Daniel; Bouabdallah, Krimo; Ghesquieres, Herve; Damaj, Gandhi; Dupriez, Brigitte; Vargaftig, Jacques; Gonzalez, Alberto; Houillier, Caroline; Taillandier, Luc; Hoang-Xuan, Khe; Leblond, Veronique

2012-01-01

319

Five Years' Experience Treating Locally Advanced Cervical Cancer With Concurrent Chemoradiotherapy and High-Dose-Rate Brachytherapy: Results From a Single Institution  

SciTech Connect

Purpose: To assess the clinical outcomes after concurrent cisplatin chemotherapy and radiotherapy (RT) followed by high-dose-rate brachytherapy for locally advanced carcinoma of the cervix and perform a multivariate analysis of the prognostic factors. Methods and Materials: The outcomes were analyzed for all women treated between 1999 and 2004 with concurrent cisplatin chemotherapy and RT followed by high-dose-rate brachytherapy. Kaplan-Meier analysis was used for overall survival (OS), local control (LC), and distant control (DC). The Cox proportional hazards model was used to perform multivariate analysis of the prognostic variables. Results: The standard regimen comprised whole pelvic external RT 45 Gy in 25 fractions with concurrent weekly cisplatin 40 mg/m{sup 2}, followed by four high-dose-rate brachytherapy insertions of 6 Gy. Patients with radiologically enlarged para-aortic lymph nodes underwent extended-field RT. Of 92 patients, the OS rate was 72% at 2 years and 55% at 5 years. The LC rate was 76% at 2 years and 67% at 5 years. The DC rate was 68% at 2 years and 48% at 5 years. The most important prognostic factor for OS, LC, and DC was the pretreatment hemoglobin. For OS, the tumor size and the presence of enlarged lymph nodes were also important. For LC, the number of brachytherapy insertions was important; and for DC, the number of chemotherapy treatments was important. Of the patients, 4% experienced late Grade 3 or 4 toxicity. Conclusion: The results of our study have shown that the regimen is effective, with acceptable long-term side effects. In this cohort, the most important prognostic factor was the pretreatment hemoglobin level, a disease-related factor. However, more effective systemic treatments are needed.

Parker, Kate; Gallop-Evans, Eve [Velindre Cancer Centre, Whitchurch, Cardiff (United Kingdom); Hanna, Louise [Velindre Cancer Centre, Whitchurch, Cardiff (United Kingdom)], E-mail: louise.hanna@velindre-tr.wales.nhs.uk; Adams, Malcolm [Velindre Cancer Centre, Whitchurch, Cardiff (United Kingdom)

2009-05-01

320

Chemotherapy-induced alopecia.  

PubMed

Chemotherapy-induced alopecia is a distressing side effect common to certain treatment regimens in oncology. Unfortunately, chemotherapy-induced alopecia is an often overlooked or minor factor among our current research priorities and thus advances in amelioration have been minimal. This review offers a comprehensive examination of the clinically relevant basic science, clinical research, and current management options for chemotherapy-induced alopecia. We emphasize that hair loss secondary to chemotherapy is not as random or nonspecific in patterns or extent of disease, as one would initially perceive. Patient support and education information and templates are provided to facilitate patient treatment. PMID:22178150

Chon, Susan Y; Champion, Rachel W; Geddes, Elizabeth R; Rashid, Rashid M

2012-07-01

321

Research on Green design of complex product based on concurrent engineering  

Microsoft Academic Search

Green design of complex product based on concurrent engineering is a complex systems engineering. It can share the information resources of concurrent engineering and green design, shorten the development period of the products, lower the cost of the products' life cycle and develop the quality of the products which is required by the concurrent engineering and green design. This paper

Xi Junjie; Jia Xiaolan; Wu Zhong; Chen Huahui

2006-01-01

322

Concurrent Prolog: A Progress Report  

Microsoft Academic Search

Concurrent Prolog is a logic programming language designed for concurrent programming and parallel execution. It is a process oriented language, which embodies dataflow synchronization and guarded-command indeterminacy as its basic control mechanisms.\\u000a The paper outlines the basic concepts and definition of the language, and surveys the major programming techniques that emerged out of three years of its use. The history

Ehud Y. Shapiro

1985-01-01

323

Concurrent Prolog: A progress report  

SciTech Connect

Concurrent Prolog is a logic programming language designed for concurrent programming and parallel execution. A process-oriented language, it embodies dataflow synchronization and guarded-command indeterminacy as its basic control mechanism. This article outlines the basic concepts and definition of the language, and surveys the major programming techniques that emerged out of three years of its use. The history of the language development, implementation, and applications are reviewed.

Shapiro, E.

1986-08-01

324

Comparison of Fusion Imaging Using a Combined SPECT/CT System and Intra-arterial CT: Assessment of Drug Distribution by an Implantable Port System in Patients Undergoing Hepatic Arterial Infusion Chemotherapy  

SciTech Connect

Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinoma of the liver. We compared the perfusion patterns of HAI chemotherapy on intra-arterial port-catheter computed tomography (iapc-CT) and fused images obtained with a combined single-photon emission computed tomography/computed tomography (SPECT/CT) system. We studied 28 patients with primary or metastatic carcinoma of the liver who bore an implantable HAI port system. All underwent abdominal SPECT using Tc-99m-MAA (185 Mbq); the injection rate was 1 mL/min, identical to the chemotherapy infusion rate, and 0.5 mL/sec for iapc-CT. Delivery was through an implantable port. We compared the intrahepatic perfusion (IHP) and extrahepatic perfusion (EHP) patterns of HAI chemotherapy on iapc-CT images and fused images obtained with a combined SPECT/CT system. In 23 of 28 patients (82%), IHP patterns on iapc-CT images and fused images were identical. In 5 of the 28 patients (18%), IHP on fusion images was different from IHP on iapc-CT images. EHP was seen on fused images in 12 of the 28 patients (43%) and on iapc-CT images in 8 patients (29%). In 17 patients (61%), upper gastrointestinal endoscopy revealed gastroduodenal mucosal lesions. EHP was revealed on fused images in 10 of these patients; 9 of them manifested gastroduodenal toxicity at the time of subsequent HAI chemotherapy. Fusion imaging using the combined SPECT/CT system reflects the actual distribution of the infused anticancer agent. This information is valuable not only for monitoring adequate drug distribution but also for avoiding potential extrahepatic complications.

Ikeda, Osamu, E-mail: osamu-3643ik@do9.enjoy.ne.jp; Kusunoki, Shinichiroh; Nakaura, Takeshi; Shiraishi, Shinya; Kawanaka, Kouichi; Tomiguchi, Seiji; Yamashita, Yasuyuki [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Department of Diagnostic Radiology (Japan); Takamori, Hiroshi; Chikamoto, Akira; Kanemitsu, Keiichiro [Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Gastroenterological Surgery (Japan)

2006-06-15

325

Dynamic Real-Time Optimistic Concurrency Control  

Microsoft Academic Search

In a recent study, we have shown that in real-time database systems that discard late transactions, optimistic concurrency control outperforms locking. Although the optimistic algorithm used in that study, OPT-BC, did not factor in transaction dead- lines in making data conflict resolution decisions, it still outper- formed a deadline-cognizant locking algorithm. In this paper, we discuss why adding deadline information

Jayant R. Haritsa; Michael J. Carey; Miron Livny

1990-01-01

326

Real-Time Index Concurrency Control  

Microsoft Academic Search

Real-time database systems are expected to rely heavily on indexes to speed up data access and, thereby, help more transactions meet their deadlines. Accordingly, high-performance index concurrency control (ICC) protocols are required to prevent contention for the index from becoming a bottleneck. In this paper, we develop real-time variants of a representative set of classical B-tree ICC protocols and, using

Jayant R. Haritsa; S. Seshadri

2000-01-01

327

Role of systemic chemotherapy in the management of resected or resectable colorectal liver metastases: a systematic review and meta-analysis of randomized controlled trials.  

PubMed

Liver metastases are a common event in patients with colorectal cancer. Surgical resection, if feasible, produces a survival benefit. We performed a systematic review of randomized clinical trials (RCT) and meta-analysis to address the question if current available studies support the use of systemic chemotherapy as an adjunct to surgery in resected/resectable patients. The search was based on major databases (Pubmed, CancerLit, Embase, Medscape and Cochrane) of published literature and selecting abstracts from major cancer meetings. We performed a literature for the January 1982-May 2010 time frame. The hazard ratios (HRs), with confidence intervals, as presented in retrieved studies, referred to the disease- and/or progression-free (DFS and/or PFS) and overall survival (OS) were extracted. The meta-analysis was carried out by the fixed-effect and the random-effects model. Three studies randomizing combined treatment vs. surgery alone for a total of 666 patients (642 evaluable for survival analysis) were selected and included in the final analysis. Evidence for chemotherapy-induced benefit in terms of both DFS (pooled HR, 0.71; CI, 0.582-0.878; p=0.001) and PFS (pooled HR, 0.75; CI, 0.620-0.910; p=0.003) was demonstrated. However, our meta-analysis failed to demonstrate a significant advantage of combined treatment in terms of OS (pooled HR, 0.743; CI, 0.527-1.045; p=0.088). Chemotherapy combined with surgical resection of colorectal liver metastases improves DFS and PFS whereas the benefit in OS is not demonstrated on the basis of the available results of RCTs. New prospective trials in the era of targeted therapy are eagerly awaited on this specific topic. PMID:22446591

Ciliberto, Domenico; Prati, Ubaldo; Roveda, Laura; Barbieri, Vito; Staropoli, Nicoletta; Abbruzzese, Alberto; Caraglia, Michele; Di Maio, Massimo; Flotta, Domenico; Tassone, Pierfrancesco; Tagliaferri, Pierosandro

2012-06-01

328

Consolidation Radiotherapy in Primary Central Nervous System Lymphomas: Impact on Outcome of Different Fields and Doses in Patients in Complete Remission After Upfront Chemotherapy  

SciTech Connect

Purpose: Avoidance radiotherapy or reduction of irradiation doses in patients with primary central nervous system lymphoma (PCNSL) in complete remission (CR) after high-dose methotrexate (HD-MTX)-based chemotherapy has been proposed to minimize the neurotoxicity risk. Nevertheless, no study has focused on the survival impact of radiation parameters, as far as we know, and the optimal radiation schedule remains to be defined. Methods and Materials: The impact on outcome and neurologic performance of different radiation fields and doses was assessed in 33 patients with PCNSL who achieved CR after MTX-containing chemotherapy and were referred to consolidation whole-brain irradiation (WBRT). Patterns of relapse were analyzed on computed tomography-guided treatment planning, and neurologic impairment was assessed by the Mini Mental Status Examination. Results: At a median follow-up of 50 months, 21 patients are relapse-free (5-year failure-free survival [FFS], 51%). WBRT doses {>=}40 Gy were not associated with improved disease control in comparison with a WBRT dose of 30 to 36 Gy (relapse rate, 46% vs. 30%; 5-year FFS, 51% vs. 50%; p = 0.26). Disease control was not significantly different between patients irradiated to the tumor bed with 45 to 54 Gy or with 36 to 44 Gy, with a 5-year FFS of 35% and 44% (p = 0.43), respectively. Twenty patients are alive (5-year overall survival, 54%); WB and tumor bed doses did not have an impact on survival. Impairment as assessed by the Mini Mental Status Examination was significantly more common in patients treated with a WBRT dose {>=}40 Gy. Conclusion: Consolidation with WBRT 36 Gy is advisable in patients with PCNSL in CR after HD-MTX-based chemotherapy. Higher doses do not change the outcome and could increase the risk of neurotoxicity.

Ferreri, Andres Jose Maria, E-mail: andres.ferreri@hsr.i [Unit of Lymphoid Malignancies, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Verona, Chiara [Unit of Lymphoid Malignancies, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Internal Medicine Unit, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Politi, Letterio Salvatore [Neuroradiology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Chiara, Anna [Unit of Radiotherapy and Tomotherapy, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Perna, Lucia [Medical Physics Unit, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy); Villa, Eugenio; Reni, Michele [Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan (Italy)

2011-05-01

329

What's New in Chemotherapy Research?  

MedlinePLUS

... about chemotherapy Next Topic To learn more What’s new in chemotherapy research? Over the years, many people ... control, and some will come back. Several exciting new uses of chemotherapy and other agents hold even ...

330

[A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy].  

PubMed

Goblet cell carcinoid of the appendix is a rare neoplasm and clinically tends to take a malignant course. Most cases are young and early stage, and the surgical strategy is available. But appropriate chemotherapy for inoperable cases with peritoneal dissemination is not established. A 77-year-old woman with a past history of appendectomy was admitted to our hospital complaining of abdominal fullness. Abdominal computed tomography showed massive ascites and slight contrast enhancement of appendix. A tumor was found by colonoscopic examination at the orifice of vermiform and was diagnosed pathologically as goblet cell carcinoid of the appendix. Laparoscopy showed multiple peritoneal dissemination. We performed intraperitoneal paclitaxel(PTX)administration at 70 mg/m(2) week without any resection of the tumor. Ascites were reduced immediately, but drug-induced interstitial pneumonia occurred due to PTX. After steroid therapy, we switched to systemic S-1 therapy. For about one year, her tumor was controlled but became worse thirteen months after diagnosis and died. It is thought that intraabdominal paclitaxel administration and systemic S-1 therapy can be one of appropriate forms of chemotherapy for inoperable peritoneal carcinomatosis from goblet cell carcinoid of appendix. PMID:19098416

Nakamura, Shingen; Kimura, Shigeaki; Kashima, Masahiro; Shichijo, Kana; Yoshida, Sumiko; Harada, Eiji; Matsushita, Takaya; Oshima, Yasushi; Tamaki, Yasutami; Horiuchi, Noriaki; Takeichi, Toshiaki; Fujimoto, Hiroshi; Masuda, Kazuhiko; Iwasaka, Naohito; Shinomiya, Sadao

2008-12-01

331

Design of the Detector II: A CMOS Gate Array for the Study of Concurrent Error Detection Techniques.  

National Technical Information Service (NTIS)

For some applications of computer systems, errors have to be detected concurrently with normal operation. This is typically done by concurrent error detection (CED) circuits. Since about 90% of errors in computer systems are caused by temporary failures, ...

H. A. Goosen M. L. Cortes E. J. McCluskey

1987-01-01

332

On the impact of concurrent downloads  

Microsoft Academic Search

Concurrent downloads accelerate information access speed for individual web users. The speed-up comes from multiple connections launched for one subject download, which leads to unfairness at user level. In this paper, we study the impact of concurrent downloads on the network. Particularly, we investigate the fairness between users who employ different downloading concurrency. We also discuss how concurrent downloads affect

Yong Liu; Weibo Gong; Prashant J. Shenoy

2001-01-01

333

Dynamics of the bounds of squared concurrence  

NASA Astrophysics Data System (ADS)

The dynamics of the quantum entanglement is a fundamental characteristic for various quantum systems. Since the computable entanglement measure for higher dimensional quantum states itself is absent, the dynamics of the entanglement expressed in an operational method will be of interest. We study the dynamics of ? , an analytical lower bound of squared concurrence, of a bipartite d?d quantum state when one party goes through an arbitrary noisy channel. For a pure input state, the range of ? is obtained explicitly. For a mixed input state, an upper bound of ? is found. Interestingly, the tangle ?' , as an upper bound of squared concurrence, also has a similar dynamical property. Our results are similar to that of Konrad and can help the estimation of high-dimension bipartite entanglement in experiments.

Liu, Zhao; Fan, Heng

2009-03-01

334

Symbolic Analysis of Concurrent Programs with Polymorphism  

NASA Technical Reports Server (NTRS)

The current trend of multi-core and multi-processor computing is causing a paradigm shift from inherently sequential to highly concurrent and parallel applications. Certain thread interleavings, data input values, or combinations of both often cause errors in the system. Systematic verification techniques such as explicit state model checking and symbolic execution are extensively used to detect errors in such systems [7, 9]. Explicit state model checking enumerates possible thread schedules and input data values of a program in order to check for errors [3, 9]. To partially mitigate the state space explosion from data input values, symbolic execution techniques substitute data input values with symbolic values [5, 7, 6]. Explicit state model checking and symbolic execution techniques used in conjunction with exhaustive search techniques such as depth-first search are unable to detect errors in medium to large-sized concurrent programs because the number of behaviors caused by data and thread non-determinism is extremely large. We present an overview of abstraction-guided symbolic execution for concurrent programs that detects errors manifested by a combination of thread schedules and data values [8]. The technique generates a set of key program locations relevant in testing the reachability of the target locations. The symbolic execution is then guided along these locations in an attempt to generate a feasible execution path to the error state. This allows the execution to focus in parts of the behavior space more likely to contain an error.

Rungta, Neha Shyam

2010-01-01

335

Is concurrent chemoradiation the standard of care for locally advanced non-small cell lung cancer? A review of guidelines and evidence.  

PubMed

In the past 15 years, the treatment of locally advanced non-small cell lung cancer (NSCLC) has shifted from radiotherapy alone. There are now schedules using induction chemotherapy, concurrent chemoradiation using either radiosensitising doses of chemotherapy or full-dose chemotherapy, consolidation chemotherapy after radiation or combinations of these options. There is no consensus on the optimal chemotherapy regimen and its scheduling and the issue of radiation dose and optimal fractionation equally remains unresolved. This overview is in two sections. First, we have evaluated a selection of international guidelines on the management of locally advanced NSCLC. We assessed the methodology by which individual guidelines were produced and the levels of evidence quoted in support of the recommendations. Second, we have updated the literature search of the 2004 Cochrane review on concurrent chemoradiation. Trials were identified that compared sequential with concurrent chemoradiation using median survival as the primary outcome measure. Two-year survival and toxicity were evaluated as secondary outcome measures. Eleven trials were identified, of which six fulfilled criteria for inclusion. The median survival for concurrent treatment was 16-17 months compared with 13-15 months with sequential treatment. Treatment-related mortality was 3% for concurrent treatment and 1.7% for sequential treatment. The rate of grade 3 or worse oesophagitis was 19% in concurrent treatment compared with 3% for sequential treatment. In conclusion, chemotherapy adds benefit to radiotherapy treatment of locally advanced NSCLC. Concurrent chemoradiation is associated with significant toxicity. The evidence to support concurrent chemoradiation as the standard of care is not robust, in spite of its recommendation within a number of guidelines. Further trials should be supported. PMID:20427167

O'Rourke, N; Macbeth, F

2010-06-01

336

Molecular adsorbent recirculating system treatment for acute hepatic failure in patients with hepatitis B undergoing chemotherapy for non-Hodgkin's lymphoma.  

PubMed

Hepatitis B virus (HBV) is a serious cause of morbidity and mortality in hepatitis B surface (HBsAg) antigen-positive patients treated with chemotherapy. Because the hepatitis is related to HBV virological reactivation, application of effective antiviral therapy, such as Lamivudine, has been attempted. Despite the use of these antiviral agents at the time of clinical hepatitis, some HBsAg-positive patients still develop hepatic failure and die. We used the Molecular Adsorbent Recirculating System (MARS) (MARS Monitor; Teraklin AG, Rostock, Germany) to treat 5 HBsAg-positive lymphoma patients with acute hepatic failure due to chemotherapy despite lamivudine treatment. Before and after each treatment we monitored the parameters of neurological status (EEG, cerebral CT and Glasgow coma score), hemodynamic parameters, acid-base equilibrium and blood gases as well as hepatic and renal function. The inclusion criteria were these of the King's College Hospital. Statistical analysis by Student t method showed significant results (P < .01). Three of 5 patients are alive without signs of reactivation of viral or hematological diseases at 1 year follow-up. The 2 patients died because MARS treatment was started too late, with Glascow coma score grade IV, hemodynamic instability, and mechanical ventilator assistance. Despite the limited number of cases, we believe that MARS can be applied to patients with a high tolerance and yield good results, but the treatment has to start at the first signs of hepatic failure. PMID:16182743

Novelli, G; Rossi, M; Ferretti, G; Nudo, F; Bussotti, A; Mennini, G; Novelli, L; Ferretti, S; Antonellis, F; Martelli, S; Berloco, P B

2005-01-01

337

Learning from Mistakes --- A Comprehensive Study on Real World Concurrency Bug Characteristics. In the proceedings of the 13th International Conference on Architecture Support for Programming Languages and Operating Systems (ASPLOS'08), March 2008  

SciTech Connect

The reality of multi-core hardware has made concurrent programs pervasive. Unfortunately, writing correct concurrent programs is dif#2;cult. Addressing this challenge requires advances in multiple directions, including concurrency bug detection, concurrent program testing, concurrent programming model design, etc. Designing effective techniques in all these directions will signi#2;cantly bene#2;t from a deep understanding of real world concurrency bug characteristics. This paper provides the #2;rst (to the best of our knowledge) comprehensive real world concurrency bug characteristic study. Specifically, we have carefully examined concurrency bug patterns, manifestation, and #2;x strategies of 105 randomly selected real world concurrency bugs from 4 representative server and client opensource applications (MySQL, Apache, Mozilla and OpenOf#2;ce). Our study reveals several interesting #2;ndings and provides useful guidance for concurrency bug detection, testing, and concurrent programming language design. Some of our #2;ndings are as follows: (1) Around one third of the examined non-deadlock concurrency bugs are caused by violation to programmers' order intentions, which may not be easily expressed via synchronization primitives like locks and transactional memories; (2) Around 34% of the examined non-deadlock concurrency bugs involve multiple variables, which are not well addressed by existing bug detection tools; (3) About 92% of the examined concurrency bugs can be reliably triggered by enforcing certain orders among no more than 4 memory accesses. This indicates that testing concurrent programs can target at exploring possible orders among every small groups of memory accesses, instead of among all memory accesses; (4) About 73% of the examined non-deadlock concurrency bugs were not #2;xed by simply adding or changing locks, and many of the #2;xes were not correct at the #2;rst try, indicating the dif#2;culty of reasoning concurrent execution by programmers.

Yuanyuan Zhou Shan Lu Soyeon Park

2008-03-01

338

Hardware Support for Relaxed Concurrency Control in Transactional Memory  

Microsoft Academic Search

Today's transactional memory systems implement the two-phase-locking (2PL) algorithm which aborts transactions every time a conflict happens. 2PL is a simple algorithm that provides fast transactional operations. However, it limits concurrency in applications with high contention by increasing the rate of aborts. More relaxed algorithms that can commit conflicting transactions have recently been shown to provide better concurrency both in

Utku Aydonat; Tarek S. Abdelrahman

2010-01-01

339

Fuzzy simulation in concurrent engineering  

NASA Technical Reports Server (NTRS)

Concurrent engineering is becoming a very important practice in manufacturing. A problem in concurrent engineering is the uncertainty associated with the values of the input variables and operating conditions. The problem discussed in this paper concerns the simulation of processes where the raw materials and the operational parameters possess fuzzy characteristics. The processing of fuzzy input information is performed by the vertex method and the commercial simulation packages POLYMATH and GEMS. The examples are presented to illustrate the usefulness of the method in the simulation of chemical engineering processes.

Kraslawski, A.; Nystrom, L.

1992-01-01

340

Acupuncture as a complementary treatment for cancer patients receiving chemotherapy.  

PubMed

Background: Medical treatment for eliminating the side effects of cancer therapy may not always be efficacious. Acupuncture is one of the most widely accepted alternative and complementary therapies in use today. In this study, we investigated the efficacy of acupuncture in patients experiencing cancer treatment side effects, including nausea, vomiting, pain, poor sleep quality and anxiety. Materials and Methods: A total of 45 inpatients who underwent chemotherapy between February and April 2013 in the Oncology Department of Numune Hospital were included in our study. Acupuncture was administered to the patients one day prior to chemotherapy, on the day of chemotherapy and one day after chemotherapy. The patients were evaluated on nausea, vomiting, pain, sleep quality and anxiety before the chemotherapy and on the 4th day of chemotherapy. Results: Of the 45 patients included in the study, 18 (40%) were female and 27 (60%) were male. A total of 25 (55.6%) had an elementary school education; 32 patients (71%) had stage 4 cancer and were treated with palliative chemotherapy (the patient characteristics are shown in Table 1). Statistically significant decreases (p<0.001) in pain, nausea, vomiting, insomnia and anxiety scores were observed after the acupuncture treatment compared to baseline. There were no differences in the age, gender, education level, stage or metastasis levels between the patient groups whose symptoms improved or were unchanged. Conclusions: Our study showed that acupuncture has positive effects in cancer treatment patients who experience nausea, vomiting, pain, poor sleep quality and anxiety as side effects of chemotherapy. Chemotherapy-related side effects in cancer patients could be decreased by the concurrent use of acupuncture. PMID:24815460

Tas, Demet; Uncu, Dogan; Sendur, Mehmet Ali; Koca, Nuran; Zengin, Nurullah

2014-01-01

341

An MCM/chip concurrent engineering validation  

NASA Astrophysics Data System (ADS)

We report on the MOST software system, which implements a concurrent physical design environment for Multi-Chip Modules. The system integrates the work of design teams distributed across a network and using different CAD systems. At present the following systems have been integrated: Cadence's Edge 2.1, Cadence's Allegro 6.1, AutoDesk's AutoCad 12.0, and Harris' Finesse. Software links were established allowing data from those systems to be shared through a ROSE (Rensselaer Object Storage Environment) database management developed under the sponsorship of the DICE program. The code was written in C++ and uses various methods to feed the information in and obtain it out of the design systems: IGES for Allegro, SKILL for Edge and dfile for Finesse, while the AutoCad link is a direct one. The DDR2 (Digital Drop Receiver, version 2) multi-chip module from Harris was entered into the system and routed utilizing a redundant route scheme. The exercise used a concurrent approach, the data defining parts and placement entered through Finesse, the parts modified in Edge, the route done in Allegro and the final merge and verification performed with the Edge tool.

Moreno, Hector; Stark, Shuane

1992-12-01

342

Chemotherapy (For Parents)  

MedlinePLUS

... using sunscreen. Back Continue Common Side Effects (continued) Hair Loss and Scalp Sensitivity Because chemotherapy often kills the ... or have a sensitive scalp. Hair thinning and hair loss may occur all over the body during treatment, ...

343

Chemotherapy of Rodent Malaria.  

National Technical Information Service (NTIS)

This report summarises the activities of the chemotherapy group for 13 months (12 months initial contract plus one month's extension). The work reported on also includes results obtained from the completion of studies commenced in Liverpool under the cont...

W. Peters

1981-01-01

344

Chemotherapy for Gallbladder Cancer  

MedlinePLUS

... not a barrier to getting chemotherapy. Hepatic artery infusion: Because giving chemo into a vein is not ... the hepatic artery. This is called hepatic artery infusion or HAI. Since the hepatic artery supplies most ...

345

Prostate Cancer: Chemotherapy  

MedlinePLUS

... Lorem ipsum dolor sit amet, consectetur adipiscing elit. Prostate Cancer: Chemotherapy Prostate cancer is the third leading cause of cancer ... pain control and survival for patients with advanced prostate cancer, who have progressed despite hormonal therapy. What ...

346

Chemotherapy for Bone Cancer  

MedlinePLUS

... will order lab tests to be sure your liver, kidney, and bone marrow (which produces the cells in ... Some drugs used in chemotherapy can damage the kidneys and liver. If a drug can damage hearing, the doctor ...

347

Synthesis of VHDL concurrent processes  

Microsoft Academic Search

This paper presents two methoals for synthesis of VHDL siecijications containing concurrent processes. Our main objective is to preserve simulation\\/synthesis correspondence during high-level synthesis and to produce hardware that operates with a high degree of parallelism. The first method supports an unrestricted use of signals and wait statements and synthesizes synchronous hardware with global control of process synchronization for signal

Petru Eles; Marius Minea; Krzysztof Kuchcinski; Zebo Peng

1994-01-01

348

Concurrent Flow Lanes. Phase I.  

National Technical Information Service (NTIS)

This report provides the findings from an effort to gain a comprehensive understanding of the state-of-the-practice and state-of-the-art in modeling of nonbarrier separated electronic/high occupancy toll (HOT) lane and other concurrent flow lane operation...

C. Chou E. Miller-Hooks P. Tarnoff X. Chen

2007-01-01

349

Orchestrating concurrency in robot swarms  

Microsoft Academic Search

A functional approach to programming robot swarms brings with it well-defined properties that allow for automated concurrency and distributed execution. Further, the particular expressiveness of a pure functional language with first-class closures captures so cleanly certain biologically- inspired behaviors that program specification often becomes compact enough to allow a programmer to visually inspect the program code for the entire swarm.

Anthony Cowley; Camillo J. Taylor

2007-01-01

350

Distributed Optimistic Concurrency Control with Reduced Rollback  

Microsoft Academic Search

Concurrency control algorithms have traditionally been based on locking and timestamp ordering mechanisms. Recently, optimistic schemes have been proposed. In this paper a distributed, multi-version, optimistic concurrency control

Divyakant Agrawal; Arthur J. Bernstein; Pankaj Gupta; Soumitra Sengupta

1987-01-01

351

Concurrent algorithms for transient FE analysis  

NASA Technical Reports Server (NTRS)

Information on concurrent algorithms for transient finite element analysis is given in viewgraph form. Information is given on concurrent dynamic algorithms, interprocessor communication, the performance of the BAR problem on the 32 Processor Hypercube, computational efficiency and accuracy analysis.

Ortiz, M.; Nour-Omid, B.

1989-01-01

352

Concurrence classes for general pure multipartite states  

NASA Astrophysics Data System (ADS)

We propose concurrence classes for general pure multipartite states based on an orthogonal complement of a positive operator-valued measure on quantum phase. In particular, we construct Wm class, GHZm, and GHZm-1 class concurrences for general pure m-partite states. We give explicit expressions for W3 and GHZ3 class concurrences for general pure three-partite states and for W4, GHZ4 and GHZ3 class concurrences for general pure four-partite states.

Heydari, Hoshang

2005-10-01

353

Concurrent Prime Number Test Model  

NSDL National Science Digital Library

The Concurrent Prime Number Test Model uses the trial division algorithm to decide if a number is prime.  The prime division algorithm is inefficient and we use it here only to test the EJS implementation of the Parallel Region Element in EJS.  A parallel region executes independent code in threads that execute simultaneously on a multi-core processor.  The screen capture shows that the total execution time for four computations on a quad-core processor is only one millisecond longer than the execution time for the longest single computation.  This linear speedup is close to the theoretical maximum. The Concurrent Prime Number Test Model was created using the Easy Java Simulations (EJS) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the model's jar file will run the simulation if Java is installed.

Christian, Wolfgang

2012-01-19

354

Spontaneous remission of acute myeloid leukemia in a patient with concurrent Pneumocystis carinii pneumonia.  

PubMed

We present a case of acute myeloid leukemia which went into complete remission during the course of concurrent interstitial pneumonia caused by Pneumocystis carinii. As no antileukemic, cytostatic chemotherapy had been given, it is assumed that the infection played a major role in inducing this remission, which was however of only 6 months duration. Brief reference is made to the literature concerning the effects of infections on the course of leukemia. PMID:1803326

Fassas, A; Sakellari, I; Anagnostopoulos, A; Saloum, R

1991-01-01

355

Chemotherapy in Ewing's sarcoma  

PubMed Central

Ewing’s sarcoma constitutes three per cent of all pediatric malignancies. Ewing’s sarcoma has generally been more responsive to chemotherapy than adult-type sarcomas, and chemotherapy is now recommended for all patients with this disease. It is essential to integrate local control measures in the form of surgery and/or radiotherapy at the appropriate time, along with chemotherapy to eradicate the disease. This approach has improved the survival substantially to the tune of 70% in localized disease, although outcome for metastatic disease remains dismal. Newer therapeutic approaches are required to improve outcome for metastatic and recurrent or refractory Ewing’s sarcoma in organized co-operative group trials.

Jain, Sandeep; Kapoor, Gauri

2010-01-01

356

Neurologic complications of chemotherapy and other newer and experimental approaches.  

PubMed

Neurologic complications of conventional cytototxic agents as well as those from monoclonal antibodies and targeted therapies are increasingly observed in patients with cancer. The major categories are represented by alkylating agents (platinum compounds, ifosfamide, procarbazine, thiotepa), mitotic spindle inhibitors (vinca alkaloids, taxanes, etoposide, teniposide), proteasome inhibitors (bortezomib), antibiotics, antimetabolites, thalidomide, lenalidomide, topoisomerase inhibitors, interferon-?, hormones, bevacizumab, trastuzumab, and small tyrosine kinase inhibitors. Peripheral neuropathy is a common adverse effect of a number of chemotherapeutic drugs and often represents a critical factor limiting an adequate dose-intensity of chemotherapy. Regarding the central nervous system (CNS), it is vulnerable to many forms of toxicity from chemotherapeutic agents, including encephalopathy syndromes and confusional states, seizures, headache, cerebrovascular complications, visual loss, cerebellar syndromes, and myelopathy. For a given drug, the occurrence of CNS toxicity depends on several factors, including the total dose, route of administration, presence of structural brain lesions, exposure to prior or concurrent irradiation, and interactions with other drugs. However, many of the neurotoxic reactions are rare and idiosyncratic, and remain unpredictable. Several forms of neuroprotection and rehabilitation are being investigated. Last, the so-called "chemobrain" is an emerging issue, as it is a model of a subtle of and long-lasting damage to neuronal structures from some antineoplastic agents. PMID:24365412

Soffietti, Riccardo; Trevisan, Elisa; Rudà, Roberta

2014-01-01

357

Development of a New Subclavian Arterial Infusion Chemotherapy Method for Locally or Recurrent Advanced Breast Cancer Using an Implanted Catheter-Port System After Redistribution of Arterial Tumor Supply  

SciTech Connect

Locally or recurrent advanced breast cancers can receive arterial blood supply from various arteries, such as the internal thoracic artery (ITA), the lateral thoracic artery, and the other small arterial branches originating from the subclavian artery. Failure to catheterize and subsequent formation of collateral arterial blood supply from various arteries are some of the reasons why the response to conventional selective transarterial infusion chemotherapy is limited and variable. To overcome this problem, we developed a new subclavian arterial infusion chemotherapy method using an implanted catheter-port system after redistribution of arterial tumor blood supply by embolizing the ITA. We named this technique ('redistributed subclavian arterial infusion chemotherapy' (RESAIC)). Using RESAIC, patients can be treated on an outpatient basis for extended periods of time. Eleven patients underwent RESAIC, and the complete remission and partial response rate in 10 evaluable patients was 90%: complete remission [CR] n = 4, partial remission n = 4, stable disease n = 1, and not evaluable n = 1. Three of four patients with CR had no distant metastasis, and modified radical mastectomy was performed 1 month after conclusion of RESAIC. The resected specimens showed no residual cancer cells, and pathologically confirmed complete remission was diagnosed in each of these cases. Although temporary grade-3 myelosuppression was seen in three patients who were previously treated by systemic chemotherapy, there was no other drug-induced toxicity or procedure-related complications. RESAIC produced a better response and showed no major complications compared with other studies despite the advanced stage of the cancers.

Takizawa, Kenji, E-mail: taki-lrl@vy.catv.ne.jp; Shimamoto, Hiroshi, E-mail: hshima@k8.dion.ne.jp; Ogawa, Yukihisa, E-mail: yukky-p406c@nifty.com; Yoshimatsu, Misako, E-mail: misako_yosh@yahoo.co.jp; Yagihashi, Kunihiro, E-mail: yagiku@hotmail.com; Nakajima, Yasuo, E-mail: y3naka@marianna-u.ac.j [St. Marianna University School of Medicine, Department of Radiology (Japan); Kitanosono, Takashi, E-mail: tkita1@mac.co [University of Rochester Medical Center, Department of Vascular/Interventional Radiology (United States)

2009-09-15

358

A concurrent processing implementation for structural vibration analysis  

NASA Technical Reports Server (NTRS)

A concurrent processing algorithm for analysis of large aerospace structures is presented. A general description of the implementation criteria for the algorithm is given, and the results from applications to two vibration test problems are discussed. The test problems included a flexural vibration analysis of a long beam with 16 uniformly spaced supports, and a torsional vibration analysis. The computer system used to implement the algorithm was an experimental MIND system. The concurrent processing speedups for the test problems are given in a table.

Bostic, S. W.; Fulton, R. E.

1985-01-01

359

Induction chemotherapy in head and neck cancer: a new paradigm.  

PubMed

Five hundred and fifty thousand new head and neck cancer cases are diagnosed each year worldwide. They are mostly locally advanced squamous cell carcinoma with a poor prognosis in terms of locoregional and distant failure. A major challenge for patients with locally advanced squamous cell carcinoma is to achieve a high cure rate while preserving functions. Treatment strategies are designed according to the disease stage, primary site, operable status, patient age, and performance status. Surgery, radiation therapy, chemotherapy, and more recently molecular-targeted therapies are part of these strategies, but their sequence remains to be defined. Over the last 30 years, induction chemotherapy has attained an important position in the management of patients with locally advanced squamous cell carcinoma, particularly since the introduction of taxanes. The decision to deliver induction chemotherapy (and its intensification) must be considered in the light of other treatments aiming at better locoregional control (normofractioned radiotherapy, accelerated or hyperfractionated radiotherapy, addition of concurrent chemotherapy, or of targeted therapy) with or without adjuvant treatment. This review summarizes the rationale, these data, and perspectives on induction chemotherapy-based strategies. PMID:21160420

Pointreau, Yoann; Atean, Ibrahim; Fayette, Jérôme; Calais, Gilles; Lefebvre, Jean Louis

2011-08-01

360

Obtaining consent for chemotherapy  

Microsoft Academic Search

Purpose of the guideline Consent is a complex issue, which has received much attention of late, from both its medical and legal standpoints. This document sets out guidelines specifically addressing the issues which surround obtaining consent for the administra- tion of chemotherapy in the haemato-oncology setting, although most of the points considered are of relevance in all the other areas

J. Treleaven; J. O. Cullis; R. Maynard; E. Bishop; I. Ainsworth-Smith; A. Roques; A. Webb; J. Favre; D. Milligan

2006-01-01

361

Chemotherapy for gastric cancer  

PubMed Central

Metastatic gastric cancer remains a non-curative disease. Palliative chemotherapy has been demonstrated to prolong survival without quality of life compromise. Many single-agents and combinations have been confirmed to be active in the treatment of metastatic disease. Objective response rates ranged from 10-30% for single-agent therapy and 30-60% for polychemotherapy. Results of phase II and III studies are reviewed in this paper as well as the potential efficacy of new drugs. For patients with localized disease, the role of adjuvant and neoadjuvant chemotherapy and radiation therapy is discussed. Most studies on adjuvant chemotherapy failed to demonstrate a survival advantage, and therefore, it is not considered as standard treatment in most centres. Adjuvant immunochemotherapy has been developed fundamentally in Korea and Japan. A meta-analysis of phase III trials with OK-432 suggested that immunochemotherapy may improve survival of patients with curatively resected gastric cancer. Based on the results of US Intergroup 0116 study, postoperative chemoradiation has been accepted as standard care in patients with resected gastric cancer in North America. However, the results are somewhat confounded by the fact that patients underwent less than a recommended D1 lymph node dissection and the pattern of recurrence suggested a positive effect derived from local radiotherapy without any effect on micrometastatic disease. Neoadjuvant chemotherapy or chemoradiation therapy remains experimental, but several phase II studies are showing promising results. Phase III trials are needed.

Sastre, Javier; Garcia-Saenz, Jose Angel; Diaz-Rubio, Eduardo

2006-01-01

362

Manufacturing process and material selection in concurrent collaborative design of MEMS devices  

Microsoft Academic Search

In this paper we present knowledge of an intensive approach and system for selecting suitable manufacturing processes and materials for microelectromechanical systems (MEMS) devices in concurrent collaborative design environment. In the paper, fundamental issues on MEMS manufacturing process and material selection such as concurrent design framework, manufacturing process and material hierarchies, and selection strategy are first addressed. Then, a fuzzy

Xuan F. Zha; H. Du

2003-01-01

363

Quality of Life Assessment After Concurrent Chemoradiation for Invasive Bladder Cancer: Results of a Multicenter Prospective Study (GETUG 97-015)  

Microsoft Academic Search

Purpose: To evaluate bladder preservation and functional quality after concurrent chemoradiotherapy for muscle-invasive cancer in 53 patients included in a Phase II trial. Patient and Methods: Pelvic irradiation delivered 45Gy, followed by an 18-Gy boost. Concurrent chemotherapy with cisplatin and 5-fluorouracil by continuous infusion was performed at Weeks 1, 4, and 7 during radiotherapy. Patients initially suitable for surgery were

Jean-Léon Lagrange; Caroline Bascoul-Mollevi; Lionnel Geoffrois; Véronique Beckendorf; Jean-Marc Ferrero; Florence Joly; Nedjila Allouache; Jean-Marc Bachaud; Christine Chevreau; Andrew Kramar; Bruno Chauvet

2011-01-01

364

ASSOCIATION BETWEEN BONE MARROW DOSIMETRIC PARAMETERS ANDACUTE HEMATOLOGIC TOXICITY IN ANAL CANCER PATIENTS TREATED WITH CONCURRENT CHEMOTHERAPYAND INTENSITY-MODULATED RADIOTHERAPY  

Microsoft Academic Search

Purpose: To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10 and 20 Gy or more (PBM-V10 and PBM-V20) is associated with acute hematologic toxicity (HT) in anal cancer patients treated with concurrent chemoradiotherapy. Methods and Materials: We analyzed 48 consecutive anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiation therapy. The median radiation dose

LOREN K. MELL; DAVID A. SCHOMAS; JOSEPH K. SALAMA; HEDY L. KINDLER; ARNO J. MUNDT; JOHN C. ROESKE; STEVEN J. CHMURA

2008-01-01

365

Preparing HEP software for concurrency  

NASA Astrophysics Data System (ADS)

The necessity for thread-safe experiment software has recently become very evident, largely driven by the evolution of CPU architectures towards exploiting increasing levels of parallelism. For high-energy physics this represents a real paradigm shift, as concurrent programming was previously only limited to special, well-defined domains like control software or software framework internals. This paradigm shift, however, falls into the middle of the successful LHC programme and many million lines of code have already been written without the need for parallel execution in mind. In this paper we have a closer look at the offline processing applications of the LHC experiments and their readiness for the many-core era. We review how previous design choices impact the move to concurrent programming. We present our findings on transforming parts of the LHC experiment reconstruction software to thread-safe code, and the main design patterns that have emerged during the process. A plethora of parallel-programming patterns are well known outside the HEP community, but only a few have turned out to be straightforward enough to be suited for non-expert physics programmers. Finally, we propose a potential strategy for the migration of existing HEP experiment software to the many-core era.

Clemencic, M.; Hegner, B.; Mato, P.; Piparo, D.

2014-06-01

366

Prevalence and risk factors of cataract after chemotherapy with or without central nervous system irradiation for childhood acute lymphoblastic leukaemia: an LEA study.  

PubMed

Corticosteroid and central nervous system (CNS) irradiation can induce cataract in childhood lymphoblastic leukaemia survivors. Few prospective studies with systematic ophthalmological evaluation have been published. Cataract was prospectively assessed by serial slip lamp tests in 517 patients. All had acute lymphoblastic leukaemia, all had been treated by chemotherapy with or without CNS irradiation, and none had received haematopoietic stem cell transplantation. Median ages at last evaluation and follow-up duration from leukaemia diagnosis were 16·8 and 10·9 years, respectively. Cataract was observed in 21/517 patients (4·1%). Cumulative incidence was 4·5 ± 1·2% at 15 years and reached 26 ± 8·1% at 25 years. CNS irradiation was the only risk factor: prevalence was 11·1% in patients who had received irradiation and 2·8% in those who did not. We did not detect any steroid dose effect: cumulative dose was 5133 and 5190 mg/m(2) in patients with and without cataract, respectively. Cataract occurrence did not significantly impact quality of life. We conclude that, in the range of steroid dose reported here, the cataract risk proves very low 15 years after treatment without CNS irradiation but an even more prolonged follow-up is required because of potential very late occurrence. PMID:24116693

Alloin, Anne-Lise; Barlogis, Vincent; Auquier, Pascal; Contet, Audrey; Poiree, Maryline; Demeocq, François; Herrmann, Iris; Villes, Virginie; Bertrand, Yves; Plantaz, Dominique; Kanold, Justyna; Chastagner, Pascal; Chambost, Hervé; Sirvent, Nicolas; Michel, Gérard

2014-01-01

367

Concurrence of superpositions of many states  

SciTech Connect

In this paper, we use the concurrence vector as a measure of entanglement, and investigate lower and upper bounds on the concurrence of a superposition of bipartite states as a function of the concurrence of the superposed states. We show that the amount of entanglement quantified by the concurrence vector is exactly the same as that quantified by I concurrence, so that our results can be compared to those given in Phys. Rev. A 76, 042328 (2007). We obtain a tighter lower bound in the case in which the two superposed states are orthogonal. We also show that when the two superposed states are not necessarily orthogonal, both lower and upper bounds are, in general, tighter than the bounds given in terms of the I concurrence. An extension of the results to the case with more than two states in the superpositions is also given.

Akhtarshenas, Seyed Javad [Department of Physics, University of Isfahan, Isfahan, Iran and Quantum Optics Group, University of Isfahan, Isfahan (Iran, Islamic Republic of)

2011-04-15

368

[Soft tissue sarcoma: postoperative chemotherapy].  

PubMed

In high-grade musculoskeletal sarcomas, adjuvant chemotherapy is often performed to prevent distant metastases. The efficacy of chemotherapy varies according to the histological type of sarcoma. Prognoses are poor in patients with osteosarcoma, Ewing's sarcoma, or rhabdomyosarcoma, when surgery alone is performed. However, because these sarcomas are chemosensitive, their prognoses are improved with adjuvant chemotherapy. On the other hand, the efficacy of chemotherapy is not statistically demonstrated in non-round cell sarcomas, e. g., malignant fibrous histiocytoma. Nowadays, several kinds of antitumor agents are usually used for adjuvant chemotherapy, and many authors have reported various kinds of regimens and their clinical results. Commonly used drugs include adriamycin, ifosfamide, cisplatin, methotrexate, cyclophosphamide, dacarbazine, vincristine, and actinomycin-D. Recently, high-dose chemotherapy combined with autologous peripheral blood or bone marrow stem cell transplantation has been begun in patients who do not respond to standard chemotherapy, and a better prognosis is expected. PMID:15446551

Goto, Takahiro; Kosaku, Hidemi; Kobayashi, Hiroshi; Hozumi, Takahiro; Kondo, Taiji

2004-09-01

369

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation  

Microsoft Academic Search

BACKGROUND: The objective of this retrospective study is to investigate laryngeal preservation and long-term treatment results in hypopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) combined with chemotherapy. METHODS: Twenty-seven patients with hypopharyngeal carcinoma (stage II-IV) were enrolled and underwent concurrent chemoradiotherapy. The chemotherapy regimens were monthly cisplatin and 5-fluorouracil for six patients and weekly cisplatin for 19 patients. All patients

Wen-Shan Liu; Chung-Han Hsin; Ying-Hsiang Chou; Jung-Tung Liu; Ming-Fang Wu; Szu-Wen Tseng; Jong-Kang Lee; Hsien-Chun Tseng; Tzu-Hwei Wang; Mao-Chang Su; Huei Lee

2010-01-01

370

Altered Cerebral Blood Flow One Month after Systemic Chemotherapy for Breast Cancer: A Prospective Study Using Pulsed Arterial Spin Labeling MRI Perfusion  

PubMed Central

Cerebral structural and functional alterations have been reported after chemotherapy for non-CNS cancers, yet the causative mechanism behind these changes remains unclear. This study employed a novel, non-invasive, MRI-based neuroimaging measure to provide the first direct longitudinal measurement of resting cerebral perfusion in breast cancer patients, which was tested for association with changes in cognitive function and gray matter density. Perfusion was measured using pulsed arterial spin labeling MRI in women with breast cancer treated with (N?=?27) or without (N?=?26) chemotherapy and matched healthy controls (N?=?26) after surgery before other treatments (baseline), and one month after chemotherapy completion or yoked intervals. Voxel-based analysis was employed to assess perfusion in gray matter; changes were examined in relation to overall neuropsychological test performance and frontal gray matter density changes measured by structural MRI. Baseline perfusion was not significantly different across groups. Unlike control groups, chemotherapy-treated patients demonstrated significantly increased perfusion post-treatment relative to baseline, which was statistically significant relative to controls in the right precentral gyrus. This perfusion increase was negatively correlated with baseline overall neuropsychological performance, but was not associated with frontal gray matter density reduction. However, decreased frontal gray matter density was associated with decreased perfusion in bilateral frontal and parietal lobes in the chemotherapy-treated group. These findings indicate that chemotherapy is associated with alterations in cerebral perfusion which are both related to and independent of gray matter changes. This pattern of results suggests the involvement of multiple mechanisms of chemotherapy-induced cognitive dysfunction. Additionally, lower baseline cognitive function may be a risk factor for treatment-associated perfusion dysregulation. Future research is needed to clarify these mechanisms, identify individual differences in susceptibility to treatment-associated changes, and further examine perfusion change over time in survivors.

McDonald, Brenna C.; Conroy, Susan K.; Smith, Dori J.; West, John D.; O'Neill, Darren P.; Schneider, Bryan P.; Saykin, Andrew J.

2014-01-01

371

Concurrence classes for general pure multipartite states  

Microsoft Academic Search

We propose concurrence classes for general pure multipartite states based on an orthogonal complement of a positive operator-valued measure on quantum phase. In particular, we construct Wm class, GHZm, and GHZm-1 class concurrences for general pure m-partite states. We give explicit expressions for W3 and GHZ3 class concurrences for general pure three-partite states and for W4, GHZ4 and GHZ3 class

Hoshang Heydari

2005-01-01

372

Multiversion Concurrency Control for Multidimensional Index Structures  

Microsoft Academic Search

Prevailing concurrency control mechanisms for multidimensional index structures, such as the Generalized Search Tree (GiST),\\u000a are based on locking techniques. These approaches may cause significant overhead in settings where the indexed data is rarely\\u000a updated and read access is highly concurrent. In this paper we present the Multiversion-GiST (MVGiST), which extends the GiST\\u000a with Multiversion Concurrency Control. Beyond enabling lock-free

Walter Binder; Samuel Spycher; Ion Constantinescu; Boi Faltings

2007-01-01

373

Chemotherapy in pregnancy.  

PubMed

One in 1000 pregnancies is complicated with cancer with the most common tumors being breast cancer, cervical cancer, thyroid, leukemia, lymphoma, and ovarian cancer. It is often assumed that cancer during pregnancy necessitates sacrificing the well-being of the fetus but in most cases appropriate treatment can be offered to the mother without placing the fetus at serious risk. The care of a pregnant woman with cancer involves evaluation of competing maternal and fetal risks and benefits. Although it is rare to administer chemotherapy during pregnancy, the risks depend on the drugs used and the gestational age of the fetus. During the period of organogenesis (4 to 13 wk), administration of cytotoxic drugs carries an increased risk of fetal malformations and fetal loss. Chemotherapy in the second or third trimester is associated with intrauterine growth retardation, prematurity, and low birth weight and bone marrow toxicity in many exposed infants. PMID:22031250

Brewer, Molly; Kueck, Angela; Runowicz, Carolyn D

2011-12-01

374

Chemotherapy-Induced Neuropathy  

Microsoft Academic Search

Opinion Statement  Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most severe and unpredictable side effects of modern anticancer\\u000a treatment. In recent years, a clear understanding of the importance of an integrated approach to CIPN has become evident,\\u000a and efforts are increasing to better characterize its features and to identify more accurate methods to report and grade its\\u000a occurrence. The clinically

Guido Cavaletti; Paola Alberti; Barbara Frigeni; Marialuisa Piatti; Emanuela Susani

2011-01-01

375

The role of product safety and liability in concurrent engineering  

Microsoft Academic Search

This paper explores the role of product safety and liability in the early stages of product design in a concurrent engineering environment. The paper presents an overview of literature pertaining to the significance of product liability for manufacturers. Further, the paper presents a system approach to product safety, a conceptual framework for design for safety and liability, and a product

S Dowlatshahi

2001-01-01

376

PWR steamline break analysis assuming concurrent steam generator tube rupture  

SciTech Connect

Results are presented for a steamline break analysis for a typical, two-loop, 2560 MW(t) pressurized water reactor. The calculations were performed using the IRT reactor system transient analysis code. Included are the analyses of steamline break transients assuming concurrent steam generator tube rupture (up to 30 steam generator tubes). Graphical and tabular results are presented.

Shier, W.G.; Levine, M.M.

1980-01-01

377

A multi-version concurrency scheme with no rollbacks  

Microsoft Academic Search

The multi-version data item concept is a method for increasing concurrency in a database system. All previously proposed schemes utilizing this concept relied on transaction rollback as a means for preserving consistency. These rollbacks require a considerable amount of overhead which degrades performance. In this paper we develop a new scheme that utilizes the multi-version data item concept. Our proposed

Abraham Silberschatz

1982-01-01

378

Factorization law for two lower bounds of concurrence  

SciTech Connect

We study the dynamics of two lower bounds of concurrence in bipartite quantum systems when one party goes through an arbitrary channel. We show that these lower bounds obey the factorization law similar to that of [Konrad et al., Nat. Phys. 4, 99 (2008)]. We also discuss the application of this property in an example.

Mirafzali, Sayyed Yahya; Sargolzahi, Iman; Ahanj, Ali; Javidan, Kurosh; Sarbishaei, Mohsen [Department of Physics, Ferdowsi University of Mashhad, Mashhad (Iran, Islamic Republic of); Khayyam Institute of Higher Education, Mashhad, Iran and School of Physics, Institute for Research in Fundamental Science (IPM), P. O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Department of Physics, Ferdowsi University of Mashhad, Mashhad (Iran, Islamic Republic of)

2010-09-15

379

Efficient Optimistic Concurrency Control Using Loosely Synchronized Clocks  

Microsoft Academic Search

This paper describes an efficient optimistic concurrency control scheme for use in distributed database systems in which objects are cached and manipulated at client machines while persistent storage and transactional support are provided by servers. The scheme provides both serializability and external consistency for committed transactions; it uses loosely synchronized clocks to achieve global serialization. It stores only a single

Atul Adya; Robert Gruber; Barbara Liskov; Umesh Maheshwari

1995-01-01

380

Scalable nonblocking concurrent objects for mission critical code  

Microsoft Academic Search

The high degree of complexity and autonomy of future robotic space missions, such as Mars Science Laboratory (MSL), poses serious challenges in assuring their reliability and efficiency. Pro- viding fast and safe concurrent synchronization is of critical im- portance to such autonomous embedded software systems. The ap- plication of nonblocking synchronization is known to help elimi- nate the hazards of

Damian Dechev; Bjarne Stroustrup

2009-01-01

381

[Chemotherapy of urologic metastases].  

PubMed

Antiblastic chemotherapy of the urological tumors proves to be effective in germ-cell testicular tumor, in bladder cancer and in penis cancer, while a real effective anti-cancer therapy for prostatic and renal cell cancer has not found yet. There is not a significant difference between BVP and BEP regimens as first-line treatments of the good risk germ-cell testicular tumors. On the contrary BEP showed a lower toxicity and an higher efficacy in the treatment of the poor risk patients. Considering salvage therapies, PEI regimen proves to be as the most effective, also in the management of patients pretreated with BEP; high dose chemotherapy with autologous bone marrow transplant is currently examined as third-line therapy. In the treatment of bladder cancer the most effective drugs are Methotrexate, Adriamycin, Vinblastine and Cyclophosphamide, that, when combined, are sensitively more efficacious. The different chemotherapies achieved elevated percentage of Complete and Partial Responses (CR+PR): however these results are maintained in only 10% of the cases. So far the aim of the last studies is to improve the results both with a modification of posology and of the schedule of administration, and with the employ of growth-factors to reduce toxicity. An appreciable improvement in the treatment of locally advanced penis cancer has been achieved employing VBM regimen as adjuvant therapy, especially for patients with extrinsic lymph-nodal metastases, who underwent bilateral inguinal and iliac lymphadenectomy.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1570524

Zanoni, F; Piva, L; Milani, A; Salvioni, R; Faustini, M; Nicolai, N; Mangiarotti, B; Pizzocaro, G

1992-03-01

382

Exclusive Alternating Chemotherapy and Radiotherapy in Nonmetastatic Inflammatory Breast Cancer: 20 Years of Follow-Up  

SciTech Connect

Background: Locoregional treatment of inflammatory breast cancer (IBC) is crucial because local relapses may be highly symptomatic and are commonly associated with distant metastasis. With a median follow-up of 20 years, we report here the long-term results of a monocentric clinical trial combining primary chemotherapy (CT) with a schedule of anthracycline-based CT and an alternating split-course of radiotherapy (RT Asterisk-Operator CT) without mastectomy. Methods and Materials: From September 1983 to December 1989, 124 women with nonmetastatic IBC (T4d M0) were treated with three cycles of primary AVCMF chemotherapy (anthracycline, vincristine, cyclophosphamide, methotrexate, and 5-fluorouracil) and then an alternating RT Asterisk-Operator CT schedule followed by three cycles of FAC. Hormonal therapy was systematically administered: ovarian irradiation (12 Gy in four fractions) or tamoxifen 20 mg daily. Results: Local control was achieved in 82% of patients. The 10- and 20-year local relapse rates were 26% and 33%, respectively, but only 10% of locally controlled cases were not associated with concurrent distant metastasis. The 10- and 20-year overall survival rates were 39% and 19%, respectively. Severe fibrosis occurred in 54% of patients, grade 3 brachial plexus neuropathy in 4%, grade 2 pneumonitis in 9%. Grade 1, 2 and 3 cardiac toxicity was observed in 3.8%, 3.8% and 1.2% of cases respectively. Conclusions: This combined regimen allowed good long-term local control without surgery. Survival rates were similar to those obtained with conventional regimens (primary chemotherapy, total mastectomy, and adjuvant radiotherapy). Since IBC continues to be an entity with a dismal prognosis, this approach, safely combining preoperative or postoperative radiation therapy and systemic treatments, should be reassessed when suitable targeted agents are available.

Bourgier, Celine, E-mail: bourgier@igr.fr [Department of Radiation Oncology, Breast Unit, Institut Gustave Roussy, Villejuif (France); Pessoa, Eduardo Lima [Department of Radiation Oncology, Breast Unit, Institut Gustave Roussy, Villejuif (France); Dunant, Ariane [Biostatistics and Epidemiology Unit, Institut Gustave Roussy, Villejuif (France); Heymann, Steve [Department of Radiation Oncology, Breast Unit, Institut Gustave Roussy, Villejuif (France); Spielmann, Marc [Department of Medical Oncology, Institut Gustave Roussy, Villejuif (France); Uzan, Catherine [Department of Breast Surgery, Institut Gustave Roussy, Villejuif (France); Mathieu, Marie-Christine [Department of Pathology, Institut Gustave Roussy, Villejuif (France); Arriagada, Rodrigo [Department of Radiation Oncology, Breast Unit, Institut Gustave Roussy, Villejuif (France); Department of Radiation Oncology, Karolinska Institutet, Stockholm (Sweden); Marsiglia, Hugo [Department of Radiation Oncology, Breast Unit, Institut Gustave Roussy, Villejuif (France); Radiation Department University of Florence, Florence (Italy)

2012-02-01

383

Management of chemotherapy-induced peripheral neuropathy.  

PubMed

Recent advances in the development and administration of chemotherapy for malignant diseases have been rewarded with prolonged survival rates. The cost of progress has come at a price and the nervous system is frequently the target of chemotherapy-induced neurotoxicity. Unlike more immediate toxicities that effect the gastrointestinal tract and bone marrow, chemotherapy-induced neurotoxicity is frequently delayed in onset and may progress over time. In the peripheral nervous system, the major brunt of the toxicity is directed against the peripheral nerve, resulting in chemotherapy-induced peripheral neuropathy (CIPN). Chemotherapeutic agents used to treat hematologic and solid tumors target a variety of structures and functions in the peripheral nervous system, including the neuronal cell body, the axonal transport system, the myelin sheath, and glial support structures. Each agent exhibits a spectrum of toxic effects unique to its mechanism of toxic injury, and recent study in this field has yielded clearer ideas on how to mitigate injury. Combined with the call for a greater recognition of the potentially devastating ramifications of CIPN on quality of life, basic and clinical researchers have begun to investigate therapy to prevent neurotoxic injury. Preliminary studies have shown promise for some agents including glutamine, glutathione, vitamin E, acetyl-L-carnitine, calcium, and magnesium infusions, but final recommendations await prospective confirmatory studies. PMID:16834943

Stillman, Mark; Cata, Juan P

2006-08-01

384

Long-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma  

PubMed Central

Background/Aims Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more effective than PDT alone. Methods In total, 161 patients with cholangiocarcinoma diagnosed between February 1999 and September 2009 were evaluated. Sixteen patients were treated with PDT and chemotherapy (group A), and 58 were treated with PDT (group B). Results The median survival was 538 days (95% confidence interval [CI], 475.3 to 600.7) in group A and 334 days (95% CI, 252.5 to 415.5) in group B (p=0.05). Lymph node metastasis status, serum bilirubin of pretreatment, tumor node metastasis stage, treatment method (PDT with chemotherapy vs PDT alone), time to PDT and the number of PDT sessions were prognostic factors with statistical significance in the univariate analysis. A multivariate analysis showed that PDT with chemotherapy and more than two sessions of PDT were significant independent predictors of longer survival in advanced cholangiocarcinoma (hazard ratio [HR], 2.23; 95% CI, 1.18 to 4.20; p=0.013 vs HR, 1.79; 95% CI, 1.044 to 3.083; p=0.034). Conclusions PDT with chemotherapy results in longer survival than PDT alone.

Hong, Mi Jin; Lee, Eung Jun; Lee, Tae Yoon; Shim, Chan Sup

2014-01-01

385

The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses  

Microsoft Academic Search

Major mechanisms underlying poor im- mune responses to autologous tumor- associated antigens are overwhelming tu- mor kinetics and the absence of effective T-cell costimulation by antigen-present- ing cells. To address these issues, leuke- mia and lymphoma mice were treated with the combination of chemotherapy and systemic immunotherapy with recom- binant soluble murine B7-immunoglobu- lin G (IgG) molecules. In this report,

Kathlene Runyon; Kwang Lee; Krystyna Zuberek; Mary Collins; John P. Leonard; Kyriaki Dunussi-Joannopoulos

2001-01-01

386

Concurrent Macular Corneal Dystrophy and Keratoconus  

PubMed Central

A 21-year-old female presented with progressive bilateral visual loss for the past 8 years. The patient had no history of systemic disease, surgery or medications. Complete ophthalmologic examination and topography were performed. On ophthalmic examination, uncorrected visual acuity was counting fingers at 2.5 m (20/50 with pinhole) in the right and left eyes. Both corneas appeared hazy on gross examination. On slit-lamp biomicroscopy, focal grayish-white opacities with indistinct borders were noted in the superficial and deep corneal stroma of both eyes. Both corneas were thin and bulging. Corneal topography showed a pattern consistent with keratoconus. The patient underwent penetrating keratoplasty (PKP). Histopathologic studies after PKP confirmed the diagnosis of macular corneal dystrophy and keratoconus in the same eye. The patient was clinically diagnosed as a case of concurrent macular dystrophy and keratoconus, which is a very rare presentation.

Mohammad-Rabei, Hossein; Shojaei, Ahmad; Aslani, Mehdi

2012-01-01

387

99mTc-Sestamibi Using a Direct Conversion Molecular Breast Imaging System to Assess Tumor Response to Neoadjuvant Chemotherapy in Women With Locally Advanced Breast Cancer  

PubMed Central

Purpose The objective of this study was to determine the ability of breast imaging with 99mTc-sestamibi and a direct conversion–molecular breast imaging (MBI) system to predict early response to neoadjuvant chemotherapy (NAC). Methods Patients undergoing NAC for breast cancer were imaged with a direct conversion–MBI system before (baseline), at 3 to 5 weeks after onset, and after completion of NAC. Tumor size and tumor-to-background (T/B) uptake ratio measured from MBI images were compared with extent of residual disease at surgery using the residual cancer burden. Results Nineteen patients completed imaging and proceeded to surgical resection after NAC. Mean reduction in T/B ratio from baseline to 3 to 5 weeks for patients classified as RCB-0 (no residual disease), RCB-1 and RCB-2 combined, and RCB-3 (extensive residual disease) was 56% (SD, 0.20), 28% (SD, 0.20), and 4% (SD, 0.15), respectively. The reduction in the RCB-0 group was significantly greater than in RCB-1/2 (P = 0.036) and RCB-3 (P = 0.001) groups. The area under the receiver operator characteristic curve for determining the presence or absence of residual disease was 0.88. Using a threshold of 50% reduction in T/B ratio at 3 to 5 weeks, MBI predicted presence of residual disease at surgery with a diagnostic accuracy of 89.5% (95% confidence interval [CI], 0.64%–0.99%), sensitivity of 92.3% (95% CI, 0.74%–0.99%), and specificity of 83.3% (95% CI, 0.44%–0.99%). The reduction in tumor size at 3 to 5 weeks was not statistically different between RCB groups. Conclusions Changes in T/B ratio on MBI images performed at 3 to 5 weeks following initiation of NAC were accurate at predicting the presence or absence of residual disease at NAC completion.

Mitchell, David; Hruska, Carrie B.; Boughey, Judy C.; Wahner-Roedler, Dietlind L.; Jones, Katie N.; Tortorelli, Cindy; Conners, Amy Lynn; O'Connor, Michael K.

2014-01-01

388

Treatment of small cell carcinoma of lung with combined high dose mediastinal irradiation, whole brain prophylaxis and chemotherapy  

SciTech Connect

Survival of patients with small cell carcinoma of lung, treated on a new combined radiotherapy-chemotherapy protocol, compares favorably with other regimens in the literature and our own previous combined approaches. Radiation, given after induction chemotherapy, consisted of whole brain prophylaxis in all 44 evaluable patients. Patients with limited disease were also treated to the primary and mediastinum to a high dose (5000 rad equivalent) using multiple fields. The new chemotherapy regimen consisted of induction with cyclophosphamide, doxorubicin, and vincristine alternated with cis-platinum and VP-16 (an epipodophyllotoxin) for two cycles, followed by consolidation with low dose cyclophosphamide and vincristine concurrent with irradiation. Patients with limited disease who achieved less than complete response, and all patients with extensive disease were not continued on maintenance chemotherapy. Out of 24 evaluable patients with limited disease, there was 73% survival at 1 year by life-table analysis, measured from treatment initiation. After induction, 16/24 of these limited disease patients were CR (complete responders): 20/24 were CR at completion of their irradiation. Out of 20 evaluable patients with extensive disease, there was 59% survival at 1 year by life-table analysis. Only 4/44 (9%) brain parenchymal relapses occurred, one at 3 months and one at 6 months after local failure and two in patients who did not become CRs, implicating a possible re-seeding mechanism. Five patients had central nervous system relapses outside of brain parenchyma (spinal epidural and leptomeningeal); in three patients this was the initial site of failure. Significant complications included leukopenia (50%) and thrombocytopenia (24%) primarily during induction, and chronic pulmonary fibrosis (25%), possibly contributing to two deaths.

Shank, B.; Natale, R.B.; Hilaris, B.S.; Wittes, R.E.

1981-04-01

389

Apologizing versus asking permission: optimistic concurrency control for abstract data types  

Microsoft Academic Search

An optimistic concurrency control technique is one that allows transactions to execute without synchronization, relying on commit-time validation to ensure serializability. Several new optimistic concurrency control techniques for objects in decentralized distributed systems are described here, their correctness and optimality properties are proved, and the circumstances under which each is likely to be useful are characterized.Unlike many methods that classify

Maurice Herlihy

1990-01-01

390

Using Viewpoints and CG for the Representation and Management of a Corporate Memory in Concurrent Engineering  

Microsoft Academic Search

. In Concurrent Engineering, several participants (designers, managers,...) stemmingfrom different specialities, collaborate in order to build a system. In this paper, we propose a representationwith the Conceptual Graph formalism to keep a trace of the design process in ConcurrentEngineering as a project memory. Such design process is a cycle of individual design andcollaborative evaluation. In order to facilitate knowledge extraction

Myriam Ribière

1998-01-01

391

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.  

PubMed

Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin. A critical challenge for translating this therapeutic network rewiring into clinical practice is the design of optimal drug delivery systems. We report the generation of a nanoparticle delivery vehicle that contained more than one therapeutic agent and produced a controlled sequence of drug release. Liposomes, representing the first clinically approved nanomedicine systems, are well-characterized, simple, and versatile platforms for the manufacture of functional and tunable drug carriers. Using the hydrophobic and hydrophilic compartments of liposomes, we effectively incorporated both hydrophobic (erlotinib) and hydrophilic (doxorubicin) small molecules, through which we achieved the desired time sequence of drug release. We also coated the liposomes with folate to facilitate targeting to cancer cells. When compared to the time-staggered application of individual drugs, staggered release from tumor-targeted single liposomal particles enhanced dynamic rewiring of apoptotic signaling pathways, resulting in improved tumor cell killing in culture and tumor shrinkage in animal models. PMID:24825919

Morton, Stephen W; Lee, Michael J; Deng, Zhou J; Dreaden, Erik C; Siouve, Elise; Shopsowitz, Kevin E; Shah, Nisarg J; Yaffe, Michael B; Hammond, Paula T

2014-01-01

392

Concurrency revisited: increasing and compelling epidemiological evidence  

PubMed Central

Multiple sexual partnerships must necessarily lie at the root of a sexually transmitted epidemic. However, that overlapping or concurrent partnerships have played a pivotal role in the generalized epidemics of sub-Saharan Africa has been challenged. Much of the original proposition that concurrent partnerships play such a role focused on modelling, self-reported sexual behaviour data and ethnographic data. While each of these has definite merit, each also has had methodological limitations. Actually, more recent cross-national sexual behaviour data and improved modelling have strengthened these lines of evidence. However, heretofore the epidemiologic evidence has not been systematically brought to bear. Though assessing the epidemiologic evidence regarding concurrency has its challenges, a careful examination, especially of those studies that have assessed HIV incidence, clearly indicates a key role for concurrency. Such evidence includes: 1) the early and dramatic rise of HIV infection in generalized epidemics that can only arise from transmission through rapid sequential acute infections and thereby concurrency; 2) clear evidence from incidence studies that a major portion of transmission in the population occurs via concurrency both for concordant negative and discordant couples; 3) elevation in risk associated with partner's multiple partnering; 4) declines in HIV associated with declines in concurrency; 5) bursts and clustering of incident infections that indicate concurrency and acute infection play a key role in the propagation of epidemics; and 6) a lack of other plausible explanations, including serial monogamy and non-sexual transmission. While other factors, such as sexually transmitted infections, other infectious diseases, biological factors and HIV sub-type, likely play a role in enhancing transmission, it appears most plausible that these would amplify the role of concurrency rather than alter it. Additionally, critics of concurrency have not proposed plausible alternative explanations for why the explosive generalized epidemics occurred. Specific behaviour change messaging bringing the concepts of multiple partnering and concurrency together appears salient and valid in promoting safer individual behaviour and positive social norms.

2011-01-01

393

Intraoperative intraperitoneal chemotherapy with cisplatin in epithelial ovarian cancer  

PubMed Central

Objective To assess retrospectively the feasibility of intraoperative intraperitoneal (IP) chemotherapy with cisplatin in epithelial ovarian cancer. Methods IP chemotherapy during optimal staging surgery was performed in 10 patients who were diagnosed with primary epithelial ovarian cancers between April 2008 and February 2011. Cisplatin (70 mg/m2 in 1 L normal saline solution) was administered in the abdominal cavity for 24 hours postoperatively and then adjuvant chemotherapy was started 2-4 weeks after surgery. Perioperative toxicity of the combined treatment was evaluated until the initiation of postoperative adjuvant chemotherapy. Results A total of 23 adverse events were observed in 9 of 10 patients (grade 1, 7; grade 2, 13; grade 3, 3; grade 4, 0). In descending order of frequency, adverse events affected the gastrointestinal system (n=14), hematologic system (n=6), pulmonary system (n=2), and genito-urinary system (n=1). The adverse events did not affect adjuvant systemic chemotherapy schedules. One patient experienced disease recurrence in the liver 16 months after surgery. The remaining 9 patients have been well controlled by chemotherapy and/or observation during the follow-up period of 4 to 39 months after surgery. Conclusion Intraoperative IP chemotherapy with cisplatin during surgical procedures is considered feasible for the treatment of primary epithelial ovarian cancer. Further studies, including long-term, prospective and comparative trials, are needed to validate the efficacy of this combined therapy.

Kim, Myung Joo; Jung, Yong Wook; Yoon, Bo Sung; Kim, Mi La; Joo, Won Deok; Song, Tae Jong

2012-01-01

394

Leukoencephalopathy and Disseminated Necrotizing Leukoencephalopathy Following Intrathecal Methotrexate Chemotherapy and Radiation Therapy for Central Nerve System Lymphoma or Leukemia  

PubMed Central

Objective Intrathecal methotrexate (MTX) therapy combined with whole brain radiotherapy (WBRT) is one of the major treatment modalities for leukemia and lymphoma involving the central nervous system (CNS). The purpose of this study was to retrospectively determine the incidences of leukoencephalopathy and disseminated necrotizing leukoencephalopathy (DNL) following intrathecal MTX therapy for CNS lymphoma or leukemia and to assess the potential risk factors. Methods Between January 2000 and August 2009, 143 patients with CNS lymphoma or leukemia received intrathecal MTX therapy alone or in combination with WBRT at a single institution. Patients were followed up clinically and radiologically at regular two- or three-month intervals. Medical records were reviewed to obtain information regarding the patients' demographics, medical histories, radiologic characteristics, treatments, and clinical courses. Results On follow-up MR images, leukoencephalopathy was found in 95 of 143 patients (66.4%). The median time to develop leukoencephalopathy was 6.6 months. Among those with leukoencephalopathy, four patients showed seven extensive white-matter changes with strongly enhancing lesions demonstrating DNL. Histological confirmation was done in six lesions of three patients and radiological diagnosis alone in one patient. Four lesions spontaneously disappeared on MR images without any treatment, with a mean duration of 14 months before disappearance of DNL. Conclusion Leukoencephalopathy is a common phenomenon that occurs following intrathecal MTX therapy; however, DNL occurs at a very low incidence. For newly developed enhancing lesions, consideration for the occurrence of DNL should be taken to avoid unnecessary invasive procedures or therapies.

Kim, Ji Yeon; Kim, Sung Tae; Nam, Do-Hyun; Lee, Jung-Il; Park, Kwan

2011-01-01

395

Almost free concurrency! (using GOF patterns)  

Microsoft Academic Search

We present a framework that provides concurrency-enhanced versions of the GOF object-oriented design patterns. The main benefit of our work is that if programmers improve program modularity by applying standard GOF design patterns while using the reusable pattern implementations from our framework, they receive implicit concurrency for free.

Sean L. Mooney; Hridesh Rajan; Steven M. Kautz; Wayne Rowcliffe

2010-01-01

396

Finite-grain message passing concurrent computers  

Microsoft Academic Search

Fine-grain concurrent computers, by operating at a fine grain, increase the amount of concurrency that can be efficiently exploited in a given problem. Programming is simplified because programs may be partitioned into natural units of methods and objects and these objects are addressed uniformly whether they are local or remote. The construction of these machines poses challenging problems in reducing

William J. Dally

1988-01-01

397

Concurrent objects in a process calculus  

Microsoft Academic Search

A programming style based on concurrent objects arises almost inevitably in languages where processes communicate by exchanging data on channels. Using the pict language as an experimental testbed, we introduce a simple object-based programming style and compare three techniques for controlling concurrency between methods in this setting: explicit locking, a standard choice operator, and a more refined replicated choice operator.

Benjamin C. Pierce; David N. Turner

398

Concurrence control for transactions with priorities  

NASA Technical Reports Server (NTRS)

Priority inversion occurs when a process is delayed by the actions of another process with less priority. With atomic transactions, the concurrency control mechanism can cause delays, and without taking priorities into account can be a source of priority inversion. Three traditional concurrency control algorithms are extended so that they are free from unbounded priority inversion.

Marzullo, Keith

1989-01-01

399

Aircraft composites components concurrent design process management  

Microsoft Academic Search

Airplane industry is emerging to a large scale inter-discipline co-operation among different department of the industry. Within this circumstance, design processes of the composite product have been progressed through the concept of concurrent engineering. The concurrent engineering enable high quality product with major reduction of costs and lead times. This research work describes a technique to efficiently manage the current

Peiyong Cong; Muhammad Younus; Fan Yuqing

2010-01-01

400

Concurrency control for transactions with priorities  

NASA Technical Reports Server (NTRS)

Priority inversion occurs when a process is delayed by the actions of another process with less priority. With atomic transations, the concurrency control mechanism can cause delays, and without taking priorities into account can be a source of priority inversion. In this paper, three traditional concurrency control algorithms are extended so that they are free from unbounded priority inversion.

Marzullo, Keith

1989-01-01

401

Concurrent partnerships and HIV: an inconvenient truth  

PubMed Central

The strength of the evidence linking concurrency to HIV epidemic severity in southern and eastern Africa led the Joint United Nations Programme on HIV/AIDS and the Southern African Development Community in 2006 to conclude that high rates of concurrent sexual partnerships, combined with low rates of male circumcision and infrequent condom use, are major drivers of the AIDS epidemic in southern Africa. In a recent article in the Journal of the International AIDS Society, Larry Sawers and Eileen Stillwaggon attempt to challenge the evidence for the importance of concurrency and call for an end to research on the topic. However, their "systematic review of the evidence" is not an accurate summary of the research on concurrent partnerships and HIV, and it contains factual errors concerning the measurement and mathematical modelling of concurrency. Practical prevention-oriented research on concurrency is only just beginning. Most interventions to raise awareness about the risks of