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Sample records for conejos norfolk oryctolagus

  1. Las Manas de Tio Conejo (Uncle Conejo's Tricks).

    ERIC Educational Resources Information Center

    Kennedy, James H.

    A lesson is presented that is designed to assist intermediate and advanced students of Spanish in both language proficiency and cultural understanding. Entirely in Spanish, the lesson focuses on the character of Tio Conejo, a well-known figure in Latin American folklore, offering insight into the significant contribution made to Hispanic…

  2. 78 FR 16816 - Television Broadcasting Services; Hampton-Norfolk, Virginia; Norfolk, Virginia-Elizabeth City...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; Hampton-Norfolk, Virginia; Norfolk, Virginia..., North Carolina, and to modify its television station, WHRO-TV's license to specify Norfolk,...

  3. EXTERIOR ELEVATION, LOOKING SOUTH, ALSO SHOWING THE NORFOLK SOUTHERN STEAM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR ELEVATION, LOOKING SOUTH, ALSO SHOWING THE NORFOLK SOUTHERN STEAM RESTORATION FLOOR INTERIOR WITH A DRILL PRESS (LEFT) AND BORING MILL (RIGHT). - Norfolk & Southern Steam Locomotive No. 1218, Norris Yards, East of Ruffner Road, Irondale, Jefferson County, AL

  4. 33 CFR 334.300 - Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia. 334.300 Section 334.300 Navigation and... RESTRICTED AREA REGULATIONS § 334.300 Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval...

  5. 33 CFR 334.300 - Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia. 334.300 Section 334.300 Navigation and... RESTRICTED AREA REGULATIONS § 334.300 Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval...

  6. 33 CFR 334.300 - Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia. 334.300 Section 334.300 Navigation and... RESTRICTED AREA REGULATIONS § 334.300 Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval...

  7. 78 FR 49920 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Norfolk Southern 5 Railroad Bridge, across the Elizabeth River Eastern Branch, mile 1.1, at Norfolk, VA... operating schedule, the Norfolk Southern 5 Railroad Bridge, mile 1.1, in Norfolk, VA, the draw must open... maintenance. The Norfolk Southern 5 railroad Bridge, at mile 1.1, across the Elizabeth River (Eastern...

  8. SIGN: Science, Inclusion and Growth in Norfolk.

    ERIC Educational Resources Information Center

    Lefever, David; Symonds, Lynne

    2000-01-01

    Science, Inclusion, and Growth in Norfolk (SIGN) is a Public Understanding of Science project that seeks to use the understanding of plant and soil science to demonstrate that people with severe learning difficulties can find the scientific method of inquiry a relevant and rewarding route to self-confidence and an understanding of the events that…

  9. 76 FR 70345 - Drawbridge Operation Regulations; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... operation of the Norfolk Southern 5 Railroad Bridge, mile 1.1, Norfolk, VA. Under this temporary deviation... for train crossings or periodic maintenance. The Norfolk Southern 5 Bridge, at mile 1.1, across...

  10. Norfolk and environs: A land use perspective

    USGS Publications Warehouse

    Alexander, Robert H.; Buzzanell, Peter J.; Fitzpatrick, Katherine A.; Lins, Harry F.; McGinty, Herbert K., III

    1975-01-01

    The Norfolk-Portsmouth Standard Metropolitan Statistical Area (SMSA) in southeastern Virginia was the site of intensive testing of a number of land resources assessment methods, built around the availability of remotely sensed data from the Earth Resources Technology Satellite (ERTS-I), later renamed LANDSAT I. The Norfolk tests were part of a larger experiment known as the Central Atlantic Regional Ecological Test Site (CARETS), designed to test the extent to which LANDSAT and associated high-altitude aircraft data could be used as cost-effective inputs to a regional land use information system. The Norfolk SMSA contains a variety of land uses typical of the urbanized eastern seaboard, along with typical associated problems: rapid urbanization; heavy recreational, commercial, and residential demands on fragile beaches and coastal marsh environments; industrial, transportation, and governmental land and water uses impacting on residential and agricultural areas; drainage and land stability difficulties affecting construction and other uses; and increasing difficulties in maintaining satisfactory air and water quality.

  11. 76 FR 54189 - Television Broadcasting Services; Hampton-Norfolk, Virginia; Norfolk, Virginia-Elizabeth City, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Association (``HRETA''), the licensee of noncommercial educational television station WHRO-TV, channel *16... City, North Carolina, as Elizabeth City's first local TV service. HRETA also requests modification of station WHRO-TV's license to specify Norfolk, Virginia-Elizabeth City, North Carolina as its community...

  12. Authentic Intellectual Work on School Desegregation: The Digital History of Massive Resistance in Norfolk, Virginia

    ERIC Educational Resources Information Center

    Manfra, Meghan McGlinn

    2009-01-01

    This year marks the fiftieth anniversary of the integration of Norfolk Public Schools. On February 2, 1959, the "Norfolk 17" integrated the formerly all-white public middle and high schools in Norfolk, Virginia. Less known than their counterparts in Little Rock, Arkansas, the stories of the Norfolk 17 underscore the struggle schools faced after…

  13. 78 FR 34892 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... the Norfolk Southern 5 Railroad Bridge, across the Elizabeth River Eastern Branch, mile 1.1, Norfolk... navigation position. DATES: This deviation is effective from 11 a.m. on July 8, 2013 to 1 p.m. July 16, 2013... Norfolk Southern 5 Railroad Bridge, mile 1.1, in Norfolk, VA, the draw must open promptly and fully...

  14. Radiological survey of the Norfolk Naval Station, the Norfolk Naval Shipyard, and Newport News Shipbuilding

    SciTech Connect

    Sensintaffar, E.L.; Blanchard, R.L.

    1988-10-01

    Since 1963, the Eastern Environmental Radiation Facility (EERF), US Environmental Protection Agency (USEPA), in cooperation with the US Naval Sea Systems Command (NAVSEA) has surveyed facilities serving nuclear-powered warships on the Atlantic and Pacific coasts and the Gulf of Mexico. These surveys assess whether the operation of nuclear-powered warships, during construction, maintenance, overhaul, or refueling, have created elevated levels of radioactivity. The surveys emphasize sampling those areas and pathways that could expose the public. In 1984, NAVSEA requested that EPA survey all active facilities servicing nuclear-powered warships over the next three years. This report contains the results of surveys conducted at Norfolk Naval Shipyard, Norfolk Naval Station and Newport News Shipbuilding during the period July 28 to August 1, 1986. Some of these same areas were previously surveyed by EERF personnel (at that time US Public Health Service) in January 1968. 1 ref., 4 figs., 5 tabs.

  15. VIEW OF ELM DRIVE WITH NORFOLK PINE ON RIGHT. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF ELM DRIVE WITH NORFOLK PINE ON RIGHT. VIEW FACING WEST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

  16. Applications of satellite snow cover in computerized short-term streamflow forecasting. [Conejos River, Colorado

    NASA Technical Reports Server (NTRS)

    Leaf, C. F.

    1975-01-01

    A procedure is described whereby the correlation between: (1) satellite derived snow-cover depletion and (2) residual snowpack water equivalent, can be used to update computerized residual flow forecasts for the Conejos River in southern Colorado.

  17. 75 FR 61835 - Jackson & Lansing Railroad Company-Trackage Rights Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Surface Transportation Board Jackson & Lansing Railroad Company--Trackage Rights Exemption-- Norfolk Southern Railway Company Pursuant to a written Assignment of Trackage Rights and Other Joint Facility Agreements (Trackage Agreement) dated September 16, 2010, Norfolk Southern Railway Company (NSR) has...

  18. 77 FR 74586 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ...The Coast Guard has issued a temporary deviation from the operating schedule that governs the operation of the Norfolk Southern V2.8 Railroad Bridge across the Elizabeth River (Eastern Branch), mile 2.7, at Norfolk, VA. This deviation is necessary to facilitate replacing bearings on the Norfolk Southern V2.8 Railroad Bridge. This temporary deviation will allow the drawbridge......

  19. Atmospheric particulate measurements in Norfolk, Virginia

    NASA Technical Reports Server (NTRS)

    Storey, R. W., Jr.; Sentell, R. J.; Woods, D. C.; Smith, J. R.; Harris, F. S., Jr.

    1975-01-01

    Characterization of atmospheric particulates was conducted at a site near the center of Norfolk, Virginia. Air quality was measured in terms of atmospheric mass loading, particle size distribution, and particulate elemental composition for a period of 2 weeks. The objectives of this study were (1) to establish a mean level of air quality and deviations about this mean, (2) to ascertain diurnal changes or special events in air quality, and (3) to evaluate instrumentation and sampling schedules. Simultaneous measurements were made with the following instruments: a quartz crystal microbalance particulate monitor, a light-scattering multirange particle counter, a high-volume air sampler, and polycarbonate membrane filters. To assess the impact of meteorological conditions on air quality variations, continuous data on temperature, relative humidity, wind speed, and wind direction were recorded. Particulate elemental composition was obtained from neutron activation and scanning electron microscopy analyses of polycarbonate membrane filter samples. The measured average mass loading agrees reasonably well with the mass loadings determined by the Virginia State Air Pollution Control Board. There are consistent diurnal increases in atmospheric mass loading in the early morning and a sample time resolution of 1/2 hour seems necessary to detect most of the significant events.

  20. Boron movement in a Norfolk loamy sand

    SciTech Connect

    Pinyerd, C.A.; Odom, J.W.; Long, F.L.; Dane, J.H.

    1984-06-01

    The authors studied the movement of B in a Norfolk loamy sand (Typic Paleudult) and its uptake by soybeans (Glycine max, (L.) Merr.) after 0 to 10 kg/ha B with and without 1000 kg/ha gypsum had been applied. Boron movement was monitored by periodic profile sampling and in situ soil solution sampling. Water movement was monitored by tensiometers, neutron moisture probe, and daily rainfall measurements. Boron application resulted in a linear increase in leaf tissue B and a linear decrease in yield. Gypsum application did not alleviate B toxicity or affect soil B movement. A linear relationship was found between cumulative rainfall and loss of hot-water-soluble B from the Ap and its accumulation in the BA and Btl horizons. Soil solution B collected in the Btl horizon was not affected by treatments, although we noted an increase in hot-water-soluble B in this horizon during the period of soil solution sampling. This constant soil solution B concentration with leaching suggests precipitation from a saturated solution. During a 393-d period, 85% of the B lost from the Ap was recovered in the BA and Btl horizons. This indicates that applied B may not be completely lost from the rooting zone of an Ultisol during the first year following application, even though hot-water-soluble B in the Ap horizon may be little different from areas not treated with B. 26 references, 4 figures, 2 tables.

  1. An Analysis of the Dropout Problem in Norfolk Secondary Schools.

    ERIC Educational Resources Information Center

    Spencer, Edwin C.

    The Norfolk, Virginia, city school system had the highest secondary school dropout rate in the State for the 1975-76 academic year. In the study discussed in this paper student dropouts are described from data in their academic files. The wish is expressed that by characterizing dropout prone students, something can be done to save them before…

  2. 9. Boston & Providence Railroad: Canton Viaduct. Canton, Norfolk Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Boston & Providence Railroad: Canton Viaduct. Canton, Norfolk Co., MA. (Not on NEC). (See HAER No. MA-27 for further documentation on this site). - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  3. 7. BOSTON & PROVIDENCE RAILROAD: CANTON VIADUCT. CANTON, NORFOLK CO., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. BOSTON & PROVIDENCE RAILROAD: CANTON VIADUCT. CANTON, NORFOLK CO., MA. (Not on NEC). (See HAER No. MA-27 for further documentation on this site.) - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  4. 8. BOSTON & PROVIDENCE RAILROAD: CANTON VIADUCT. CANTON, NORFOLK CO., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. BOSTON & PROVIDENCE RAILROAD: CANTON VIADUCT. CANTON, NORFOLK CO., MA. (Not on NEC). (See HAER No. MA-27 for further documentation on this site.) - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  5. Conejo Valley Unified School District Master Plan for an Educational Results Information System.

    ERIC Educational Resources Information Center

    Maloney, Dorothy

    The Conejo Valley (CA) Unified School District Educational Results Information System (ERIS), a generalized District master program assessment plan to obtain results information for decision-makers at all levels, has been developed. This plan establishes guidelines, evaluates the current status of the use of educational results information and…

  6. 78 FR 66265 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ...The Coast Guard has issued a temporary deviation from the operating schedule that governs the draw of the Norfolk Southern 5 Railroad Bridge, across the Elizabeth River Eastern Branch, mile 1.1, at Norfolk, VA. This deviation is necessary to facilitate replacing the broken tread plates and milling the top of the plates and webs to create a flat surface on the Norfolk Southern......

  7. Quaternary geology and waste disposal in South Norfolk, England

    NASA Astrophysics Data System (ADS)

    Gray, J. M.

    South Norfolk is dominated by the till plain of the Anglian Glaciation in eastern England, and therefore there are very few disused gravel pits and quarries suitable for the landfilling of municipal waste. Consequently, in May 1991, Norfolk County Council applied for planning permission to develop an above ground or 'landraise' waste disposal site at a disused U.S. World War II Airfield at Hardwick in South Norfolk. The proposal involved excavating a pit 2-4 m deep into the Lowestoft Till and overfilling it to create a hill of waste up to 10 m above the existing till plain. In general, leachate containment was to be achieved by utilising the relatively low permeability till on the floor of the site, but with reworking of the till around the site perimeter because of sand lenses in the upper part of the till. This paper examines three aspects of the proposal and the wider issues relating to Quaternary geology and waste disposal planning in South Norfolk: (i) the suitability of the till as a natural leachate containment system; (ii) the appropriateness of the landraise landform; and (iii) alternative sites. A Public Inquiry into the proposals was held in January/February 1993 and notification of refusal of planning permission was published in August 1993. Among the grounds for refusal were an inadequate knowledge of the site's geology and hydrogeology and the availability of alternative sites. The paper concludes by stressing that a knowledge of Quaternary geology is crucial to both the planning and design of landfill sites in areas of glacial/Quaternary sediments.

  8. 78 FR 79726 - Norfolk Southern Railway Company-Abandonment Exemption-in Gaston County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Gaston County, NC Norfolk Southern Railway Company (NSR) has filed a verified notice of exemption under 49 CFR part 1152 subpart F-Exempt Abandonments...

  9. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - U.S. NAVAL BASE, NORFOLK NAVAL AIR STATION

    EPA Science Inventory

    Under the Chesapeake Bay Agreement, Naval Base Norfolk is a member of the Tidewater interagency Pollution Prevention Program (TIPPP). t Norfolk, the Navy and the EPA have evaluated techniques and technologies to reduce waste generation from cooling tower operations. POA was condu...

  10. 76 FR 47645 - CSX Transportation, Inc.-Trackage Rights Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board CSX Transportation, Inc.--Trackage Rights Exemption--Norfolk Southern Railway Company Pursuant to a written trackage rights agreement, Norfolk Southern Railway Company (NSR) has agreed to grant approximately 3,290...

  11. 78 FR 2719 - BNSF Railway Company-Lease Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... TRANSPORTATION Surface Transportation Board BNSF Railway Company--Lease Exemption--Norfolk Southern Railway.... 11323-25 for BNSF Railway Company (BNSF) to lease from Norfolk Southern Railway Company approximately 1... approximately 600 feet north of the Chicago SAG Canal on the southern end in Chicago, Ill. Under the lease,...

  12. 75 FR 47461 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Register (74 FR 52143) and a notice of proposed rulemaking (NPRM) entitled ``Drawbridge Operation Regulations; Elizabeth River, Eastern Branch, Norfolk, VA'' in the Federal Register (74 FR 52158). We received..., Eastern Branch, Norfolk, VA'' in the Federal Register (75 FR 9521) and a supplemental notice of...

  13. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - UNITED STATES NAVAL BASE NORFOLK NAVAL AIR STATION

    EPA Science Inventory

    This report summarizes work conducted at the U.S. Navy's Naval Base Norfolk, Naval Air Station (NAS) located at Sewells Point in Norfolk, Virginia, under the U.S. Environmental Protection Agency's (EPA) Waste Reduction Evaluations at Federal Sites (WREAFS) Program. This project w...

  14. 75 FR 63540 - Norfolk Southern Railway Company-Trackage Rights Exemption-Illinois Central Railroad Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... Surface Transportation Board Norfolk Southern Railway Company--Trackage Rights Exemption-- Illinois Central Railroad Company Pursuant to a written trackage rights agreement dated August 17, 2010, Illinois Central Railroad Company (IC) has agreed to grant overhead trackage rights to Norfolk Southern...

  15. 76 FR 24084 - Atlantic and Western Railway, Limited Partnership-Trackage Rights Exemption-Norfolk Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Atlantic and Western Railway, Limited Partnership--Trackage Rights Exemption--Norfolk Southern Railway Company Pursuant to a written trackage rights agreement, Norfolk Southern Railway Company (NSR) has agreed to...

  16. 77 FR 47922 - CSX Transportation, Inc.-Trackage Rights Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board CSX Transportation, Inc.--Trackage Rights Exemption--Norfolk Southern Railway Company Pursuant to a written trackage rights agreement dated May 18, 2012, Norfolk Southern Railway Company (NSR) has agreed to...

  17. NORSTAR Project: Norfolk public schools student team for acoustical research

    NASA Technical Reports Server (NTRS)

    Fortunato, Ronald C.

    1987-01-01

    Development of the NORSTAR (Norfolk Public Student Team for Acoustical Research) Project includes the definition, design, fabrication, testing, analysis, and publishing the results of an acoustical experiment. The student-run program is based on a space flight organization similar to the Viking Project. The experiment will measure the scattering transfer of momentum from a sound field to spheres in a liquid medium. It is hoped that the experimental results will shed light on a difficult physics problem - the difference in scattering cross section (the overall effect of the sound wave scattering) for solid spheres and hollow spheres of differing wall thicknesses.

  18. Novel picornavirus in domestic rabbits (Oryctolagus cuniculus var. domestica).

    PubMed

    Pankovics, Péter; Boros, Ákos; Bíró, Hunor; Horváth, Katalin Barbara; Phan, Tung Gia; Delwart, Eric; Reuter, Gábor

    2016-01-01

    Picornaviruses (family Picornaviridae) are small, non-enveloped viruses with positive sense, single-stranded RNA genomes. The numbers of the novel picornavirus species and genera are continuously increasing. Picornaviruses infect numerous vertebrate species from fish to mammals, but have not been identified in a member of the Lagomorpha order (pikas, hares and rabbits). In this study, a novel picornavirus was identified in 16 (28.6%) out of 56 faecal samples collected from clinically healthy rabbits (Oryctolagus cuniculus var. domestica) in two (one commercial and one family farms) of four rabbit farms in Hungary. The 8364 nucleotide (2486 amino acid) long complete genome sequence of strain Rabbit01/2013/HUN (KT325852) has typical picornavirus genome organization with type-V IRES at the 5'UTR, encodes a leader (L) and a single 2A(H-box/NC) proteins, contains a hepatitis-A-virus-like cis-acting replication element (CRE) in the 2A, but it does not contain the sequence forming a "barbell-like" secondary structure in the 3'UTR. Rabbit01/2013/HUN has 52.9%, 52% and 57.2% amino acid identity to corresponding proteins of species Aichivirus A (genus Kobuvirus): to murine Kobuvirus (JF755427) in P1, to canine Kobuvirus (JN387133) in P2 and to feline Kobuvirus (KF831027) in P3, respectively. The sequence and phylogenetic analysis indicated that Rabbit01/2013/HUN represents a novel picornavirus species possibly in genus Kobuvirus. This is the first report of detection of picornavirus in rabbit. Further study is needed to clarify whether this novel picornavirus plays a part in any diseases in domestic or wild rabbits. PMID:26588888

  19. 33 CFR 334.300 - Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., longitude 76°20′02″ W; thence northwesterly to latitude 36°56′00″ N, longitude 76°20′08″ W; thence northerly along the eastern limit of Norfolk Harbor Channel to latitude 36°57′52″ N, longitude 76°20′00″ W; thence easterly to latitude 36°57′52″ N, longitude 76°19′35″ W; thence to latitude 36°57′47.7″ N, 76°18′57″...

  20. 33 CFR 334.300 - Hampton Roads and Willoughby Bay, Norfolk Naval Base, naval restricted area, Norfolk, Virginia.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., longitude 76°20′02″ W; thence northwesterly to latitude 36°56′00″ N, longitude 76°20′08″ W; thence northerly along the eastern limit of Norfolk Harbor Channel to latitude 36°57′52″ N, longitude 76°20′00″ W; thence easterly to latitude 36°57′52″ N, longitude 76°19′35″ W; thence to latitude 36°57′47.7″ N, 76°18′57″...

  1. Flows in the Tasman Front south of Norfolk Island

    NASA Astrophysics Data System (ADS)

    Sutton, Philip J. H.; Bowen, Melissa

    2014-05-01

    The Tasman Front is a narrow band of eastward flowing subtropical water crossing the Tasman Sea from Australia to North Cape, New Zealand. It is the link between the two subtropical western boundary currents of the South Pacific, the East Australian Current (EAC) off eastern Australia, and the East Auckland Current (EAUC) off northeastern New Zealand. Here we report the first direct measurements of flow in the Tasman Front from a moored array deployed across gaps in the submarine ridges south of Norfolk Island and hydrographic and ADCP measurements during the deployment and recovery voyages. The mean flow through the array over July 2003 to August 2004 was found to be eastward only in the upper 800 m with a transport of ˜6 Sv. Below 800 m a weak westward mean flow (˜1.5 Sv) was measured, associated with Antarctic Intermediate Water (AAIW). Using sea surface height to account for additional transport south of the moored array results in a total mean eastward transport between Norfolk Island and North Cape, New Zealand of ˜8 Sv, varying between -4 and 18 Sv. The measurements show that the Tasman Front is much shallower than either the EAC or EAUC, both of which extend below 2000 m depth, has less transport than either the EAC or EAUC and has instances of flow reversal. Thus, the Tasman Front is a weaker connection between the EAC and EAUC than the paradigm of a contiguous South Pacific western boundary current system would suggest.

  2. Digestive utilization of ozone-exposed forage by rabbits (Oryctolagus cuniculus)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A mixture of common Southern Piedmont (USA) grassland species (Lolium arundinacea, Paspalum dilatatum, Cynodon dactylon and Trifolium repens) was exposed to ozone [ambient (non-filtered; NF) and twice-ambient (2X) concentrations] and fed to individually caged New Zealand white rabbits (Oryctolagus c...

  3. 54. Virginia Route 615/Norfolk Southern Railroad. This example of a ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    54. Virginia Route 615/Norfolk Southern Railroad. This example of a prestressed concrete girder grade separation structure was built in 1959. View to the west. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  4. 75 FR 12594 - Norfolk Southern Railway Company-Discontinuance of Service Exemption in Hamilton County, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Hamilton County, OH On February 24, 2010, Norfolk Southern Railway Company (NSR) filed with the Surface... discontinue service over 5.70 miles of railroad between milepost CT 2.10 and milepost CT 7.80, in...

  5. The Medicines of Katherine, Duchess of Norfolk, 1463–71

    PubMed Central

    Kleineke, Hannes

    2015-01-01

    This article discusses the medicinal remedies consumed at the court of the Yorkist kings of England in the light of a lawsuit in the court of common pleas (edited in an appendix) between John Clerk, king’s apothecary to Edward IV, and Katherine Neville, Duchess of Norfolk, over the partial non-payment of the apothecary’s bills. It argues that the consumption of apothecaries’ wares in large quantities was not merely a direct result of the excessive diet of the late medieval aristocracy, but in itself represented a facet of the conspicuous consumption inherent in the lifestyle of this particular social class. The remedies supplied by Clerk over a period of several years and listed in the legal record are set in the context of contemporary collections of medical recipes, particularly a ‘dispensary’ in the British Library’s Harleian collection generally attributed to the king’s apothecary. PMID:26352302

  6. The Medicines of Katherine, Duchess of Norfolk, 1463-71.

    PubMed

    Kleineke, Hannes

    2015-10-01

    This article discusses the medicinal remedies consumed at the court of the Yorkist kings of England in the light of a lawsuit in the court of common pleas (edited in an appendix) between John Clerk, king's apothecary to Edward IV, and Katherine Neville, Duchess of Norfolk, over the partial non-payment of the apothecary's bills. It argues that the consumption of apothecaries' wares in large quantities was not merely a direct result of the excessive diet of the late medieval aristocracy, but in itself represented a facet of the conspicuous consumption inherent in the lifestyle of this particular social class. The remedies supplied by Clerk over a period of several years and listed in the legal record are set in the context of contemporary collections of medical recipes, particularly a 'dispensary' in the British Library's Harleian collection generally attributed to the king's apothecary. PMID:26352302

  7. Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.

    PubMed

    Magalhães, Vanessa; Abrantes, Joana; Munõz-Pajares, Antonio Jesús; Esteves, Pedro J

    2015-10-01

    The European rabbit (Oryctolagus cuniculus) natural populations within the species native region, the Iberian Peninsula, are considered a reservoir of genetic diversity. Indeed, the Iberia was a Pleistocene refuge to the species and currently two subspecies are found in the peninsula (Oryctolagus cuniculus cuniculus and Oryctolagus cuniculus algirus). The genes of the major histocompatibility complex (MHC) have been substantially studied in wild populations due to their exceptional variability, believed to be pathogen driven. They play an important function as part of the adaptive immune system affecting the individual fitness and population viability. In this study, the MHC variability was assessed by analysing the exon 2 of the DQA gene in several European rabbit populations from Portugal, Spain and France and in domestic breeds. Twenty-eight DQA alleles were detected, among which 18 are described for the first time. The Iberian rabbit populations are well differentiated from the French population and domestic breeds. The Iberian populations retained the higher allelic diversity with the domestic breeds harbouring the lowest; in contrast, the DQA nucleotide diversity was higher in the French population. Signatures of positive selection were detected in four codons which are putative peptide-binding sites and have been previously detected in other mammals. The evolutionary relationships showed instances of trans-species polymorphism. Overall, our results suggest that the DQA in European rabbits is evolving under selection and genetic drift. PMID:26307416

  8. Norfolk QOL-DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy.

    PubMed

    Vinik, Etta J; Vinik, Aaron I; Paulson, James F; Merkies, Ingemar S J; Packman, Jeff; Grogan, Donna R; Coelho, Teresa

    2014-06-01

    The Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) questionnaire is an instrument to assess QOL in diabetic polyneuropathy. The objective of this observational, cross-sectional study in 61 patients with V30M transthyretin familial amyloid polyneuropathy (TTR-FAP) and 16 healthy volunteers was to validate the Norfolk QOL-DN for assessment of QOL in TTR-FAP. Comparisons were conducted to identify the best items to discriminate disease stages and assess which individual Norfolk domains (symptoms, large fiber, small fiber, autonomic, and activities of daily living) would be most affected by disease stage. Analysis of individual items revealed a significant pattern of discrimination among disease stages (p < 0.001). Total QOL scores increased (indicating worsening) with duration of symptoms, with a steeper increase observed earlier in the course of disease. Significant correlations were observed between each Norfolk domain and other measures of neurological function. Limitations include cross-sectional study design, low patient numbers in this rare disease, and the ordinal-based character of the metric used; future areas to explore include item response theory approaches such as Rasch analysis. These results suggest the Norfolk QOL-DN is a reliable indicator of the impact of disease severity on QOL in patients with TTR-FAP. PMID:24738700

  9. Australian and Pacific contributions to the genetic diversity of Norfolk Island feral chickens

    PubMed Central

    2013-01-01

    Background Norfolk Island has a population of feral chickens which could be the result of domestic stock introduced onto the island by British settlers in 1788. However, there is ongoing debate about their origins because multiple human arrivals to the island may have brought chickens with them. Here we investigate the genetic origins of these feral chickens by sequencing their mitochondrial control region. We infer their phylogenetic relationships using a large dataset of novel sequences from Australian mainland domestic chickens and published sequences from around the world. Results Eleven control region haplotypes were found among the Norfolk Island feral and Australian mainland domestic chickens. Six of the Norfolk Island haplotypes fall within haplogroup E, but given the worldwide distribution of this haplogroup, the putative European origin of these chickens requires further investigation. One haplotype common among Norfolk Island and Australian samples belonged to a subgroup of haplogroup D, which appears to be restricted to chickens from Indonesia, Vanuatu and Guam. Conclusions Our data show that at least two mitochondrial DNA haplogroups (D and E) have contributed to the genetic make-up of Norfolk Island feral chickens. In addition, we have provided insights into the discrete geographical distribution and diversity of the chicken haplogroup D. In view of the worldwide interest in the characterisation of poultry resources, further assessment of chicken populations of Island Southeast Asia and the Pacific region is warranted. PMID:24063717

  10. 76 FR 39978 - Virginia Port Authority-Acquisition Exemption-Norfolk and Portsmouth Belt Line Railroad Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Virginia Port Authority--Acquisition Exemption--Norfolk and Portsmouth Belt... exemption under 49 CFR 1150.31 to acquire from the Norfolk and Portsmouth Belt Line Railroad Company...

  11. 77 FR 25229 - Adams-Warnock Railway, Inc.-Lease and Operation Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... Surface Transportation Board Adams-Warnock Railway, Inc.--Lease and Operation Exemption-- Norfolk Southern... exemption under ] 49 CFR 1150.31 to lease from Norfolk Southern Railway Company (NSR), and to operate, a... the lease agreement that is expected to be completed prior to the effective date of the...

  12. 78 FR 76192 - Norfolk Southern Railway Company-Discontinuance of Service Exemption-in Isle of Wight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Discontinuance of Service Exemption--in Isle of Wight, Southampton, Greensville, and Brunswick Counties, VA. On November 26, 2013, Norfolk Southern Railway Company (NSR) filed with...

  13. 75 FR 64392 - Norfolk Southern Railway Company-Abandonment Exemption-in Polk County, IA; Iowa Interstate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Polk County, IA; Iowa Interstate Railroad--Discontinuance of Service Exemption--in Polk County, IA Norfolk Southern... Interstate Railroad, Ltd., 5900 6th Street, SW., Cedar Rapids, IA 52404. If the verified notice...

  14. 75 FR 32839 - Norfolk Southern Railway Company-Trackage Rights Exemption-The West Tennessee Railroad, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... Surface Transportation Board Norfolk Southern Railway Company--Trackage Rights Exemption--The West Tennessee Railroad, LLC Pursuant to a written trackage rights agreement, The West Tennessee Railroad, LLC (WTNN) has agreed to grant overhead trackage rights to Norfolk Southern Railway Company (NSR) \\1\\...

  15. 76 FR 12224 - Autauga Northern Railroad, L.L.C.-Lease and Operation Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Surface Transportation Board Autauga Northern Railroad, L.L.C.--Lease and Operation Exemption--Norfolk Southern Railway Company Autauga Northern Railroad, L.L.C. (ANRR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to acquire by lease from Norfolk Southern Railway Company...

  16. 75 FR 7537 - Elkhart & Western Railroad Co.-Lease and Operation Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Surface Transportation Board Elkhart & Western Railroad Co.--Lease and Operation Exemption-- Norfolk Southern Railway Company Elkhart & Western Railroad Co. (EWR), a Class III rail carrier,\\1\\ has filed a... (Agreement) \\2\\ with Norfolk Southern Railway Company (NSR), approximately 23.0 miles of NSR's rail...

  17. 75 FR 71487 - Norfolk Southern Railway Company-Abandonment Exemption-in Crawford County, GA; Georgia Midland...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Crawford County, GA; Georgia Midland Railroad, Inc.\\1\\--Discontinuance of Service Exemption--in Crawford County... discontinuing railroad-- not Georgia Midland Railroad Company, as indicated in the notice. Norfolk...

  18. 77 FR 17122 - Indiana Southern Railroad, LLC-Temporary Trackage Rights Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... Surface Transportation Board Indiana Southern Railroad, LLC--Temporary Trackage Rights Exemption--Norfolk Southern Railway Company Norfolk Southern Railway Company (NSR), pursuant to a written trackage rights agreement (Agreement), has agreed to grant overhead temporary trackage rights to Indiana Southern...

  19. 76 FR 75602 - Hilton & Albany Railroad, Inc.-Lease and Operation Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... TRANSPORTATION Surface Transportation Board Hilton & Albany Railroad, Inc.--Lease and Operation Exemption-- Norfolk Southern Railway Company Hilton & Albany Railroad, Inc. (HAL), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 to lease from Norfolk Southern Railway Company (NSR) and...

  20. 78 FR 49605 - Norfolk Southern Railway Company-Discontinuance of Service Exemption-in Ontario, Seneca, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Discontinuance of Service Exemption--in Ontario, Seneca, and Wayne Counties, NY Norfolk Southern Railway Company (NSR) has filed a verified...

  1. A new, rare type of oceanic islands: The case of Norfolk Island

    NASA Astrophysics Data System (ADS)

    Nebel, O.; Whan, T.; Arculus, R. J.; O'Neill, H. S.; Yaxley, G. M.; McAlpine, S.; Smith, I. E.

    2014-12-01

    Most intra-plate oceanic islands are considered to be expressions of partial melting of hot, ascending mantle plumes. Mantle plume activity is often evident by progressively-aged volcanic island chains, early flood basalts, or elevated mantle temperatures (hot-spots). However, some isolated volcanic islands lack these characteristics. Their mantle sources, causes of melting, and geodynamic settings remain elusive. Here we present petrologic and geochemical data for an example of this type of ocean island: Norfolk Island and neighbouring Phillip Island. These islands are only 7 km apart and are located in the Southwest Pacific. They are the only sub-aerial volcanic islands on the Norfolk Ridge, which extends roughly linearly south from New Caledonia and north from New Zealand. The Norfolk Ridge is a continental slice rifted from the eastern Australian margin during opening of the Tasman Sea and the on-going break-up of Gondwana. There are a few isolated, unexplored volcanic edifices trending NNW from the Norfolk Ridge north of Norfolk Island that may be a hot spot trace. Norfolk and Phillip islands are both composed of young (ca. 2-3 Ma), primitive basalts and basaltic andesites containing abundant phenocrysts of olivine and rare pyroxene and feldspar. Major element systematics are unique among the global spectrum of ocean island basalts, with low CaO, high Al2O3, and high Na/Ti indicating that melting processes and/or the mantle source differs from that of any other OIB. However, Fe/Mn are high, similar to other OIB, and REE patterns carry the typical OIB garnet signature. The highest MgO contents approach 9 wt%. The unusual major-element chemistry results in olivine-dominated crystallization extending to low MgO (ca. 6-7 wt%), hence little increase of incompatible elements with decreasing MgO, but surprisingly Ni and Cr also remain nearly constant with MgO. Isotopic compositions (Sr-Nd-Hf) indicate either a primitive mantle source composition (ɛNd=6

  2. Norfolk State University Research Experience in Earth System Science

    NASA Technical Reports Server (NTRS)

    Chaudhury, Raj

    2002-01-01

    The truly interdisciplinary nature of Earth System Science lends itself to the creation of research teams comprised of people with different scientific and technical backgrounds. In the annals of Earth System Science (ESS) education, the lack of an academic major in the discipline might be seen as a barrier to the involvement of undergraduates in the overall ESS-enterprise. This issue is further compounded at minority-serving institutions by the rarity of departments dedicated to Atmospheric Science, Oceanography or even the geosciences. At Norfolk State University, a Historically Black College, a six week, NASA-supported, summer undergraduate research program (REESS - Research Experience in Earth System Science) is creating a model that involves students with majors in diverse scientific disciplines in authentic ESS research coupled with a structured education program. The project is part of a wider effort at the University to enhance undergraduate education by identifying specific areas of student weaknesses regarding the content and process of science. A pre- and post-assessment test, which is focused on some fundamental topics in global climate change, is given to all participants as part of the evaluation of the program. Student attitudes towards the subject and the program's approach are also surveyed at the end of the research experience. In 2002, 11 undergraduates participated in REESS and were educated in the informed use of some of the vast remote sensing resources available through NASA's Earth Science Enterprise (ESE). The program ran from June 3rd through July 12, 2002. This was the final year of the project.

  3. Geologic Map of the San Luis Hills Area, Conejos and Costilla Counties, Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Machette, Michael N.

    1989-01-01

    This report is a digital image of the U.S. Geological Survey Miscellaneous Investigations Series Map I-1906, 'Geologic map of the San Luis Hills area, Conejos and Costilla Counties, Colorado,' which was published in 1989 by Thompson and Machette, scale 1:50,000 but has been unavailable in a digital version. The map area represents the southwestern portion of the Alamosa 30' x 60' quadrangle, which is currently being remapped by the U.S. Geological Survey. The northern and eastern margins of the San Luis Hills area have been remapped at greater detail and thus small portions of the map area have been updated. The northern margin is shown on U.S. Geological Survey Open-File Report 2005-1392, the northeastern portion is shown on U.S. Geological Survey Open-File Report 2008-1124, and the eastern margin is shown on U.S. Geological Survey Open-File Report 2007-1074. The most significant changes to the 1989 map area are recognition of Lake Alamosa and its deposits (Alamosa Formation), remapping of bedrock in the northeastern San Luis Hills, and redating of volcanic units in the San Luis Hills. Although unpublished, new 40Ar/39Ar ages for volcanic units in the Conejos and Hinsdale Formations add precision to the previous K/Ar-dated rocks, but do not change the basic chronology of the units. The digital version of this map was prepared by Theodore R. Brandt by scanning the original map at 300 pixels per inch, prior to creating the press-quality (96 Mb) and standard (5 Mb) .pdf files.

  4. Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)

    PubMed Central

    Vogiatzoglou, Anna; Mulligan, Angela A.; Bhaniani, Amit; Lentjes, Marleen A.H.; McTaggart, Alison; Luben, Robert N.; Heiss, Christian; Kelm, Malte; Merx, Marc W.; Spencer, Jeremy P.E.; Schroeter, Hagen; Khaw, Kay-Tee; Kuhnle, Gunter G.C.

    2015-01-01

    Dietary intervention studies suggest that flavan-3-ol intake can improve vascular function and reduce the risk of cardiovascular diseases (CVD). However, results from prospective studies failed to show a consistent beneficial effect. Associations between flavan-3-ol intake and CVD risk in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) were investigated. Data were available from 24,885 (11,252 men; 13,633 women) participants, recruited between 1993 and 1997 into the EPIC-Norfolk study. Flavan-3-ol intake was assessed using 7-day food diaries and the FLAVIOLA Flavanol Food Composition database. Missing data for plasma cholesterol and vitamin C were imputed using multiple imputation. Associations between flavan-3-ol intake and blood pressure at baseline were determined using linear regression models. Associations with CVD risk were estimated using Cox regression analyses. Median intake of total flavan-3-ols was 1034 mg/d (range: 0–8531 mg/d) for men and 970 mg/d (0–6695 mg/d) for women, median intake of flavan-3-ol monomers was 233 mg/d (0–3248 mg/d) for men and 217 (0–2712 mg/d) for women. There were no consistent associations between flavan-3-ol monomer intake and baseline systolic and diastolic blood pressure (BP). After 286,147 person-years of follow-up, there were 8463 cardiovascular events and 1987 CVD related deaths; no consistent association between flavan-3-ol intake and CVD risk (HR 0.93, 95% CI: 0.87; 1.00; Q1 vs Q5) or mortality was observed (HR 0.93, 95% CI: 0.84; 1.04). Flavan-3-ol intake in EPIC-Norfolk is not sufficient to achieve a statistically significant reduction in CVD risk. PMID:25795512

  5. Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk).

    PubMed

    Vogiatzoglou, Anna; Mulligan, Angela A; Bhaniani, Amit; Lentjes, Marleen A H; McTaggart, Alison; Luben, Robert N; Heiss, Christian; Kelm, Malte; Merx, Marc W; Spencer, Jeremy P E; Schroeter, Hagen; Khaw, Kay-Tee; Kuhnle, Gunter G C

    2015-07-01

    Dietary intervention studies suggest that flavan-3-ol intake can improve vascular function and reduce the risk of cardiovascular diseases (CVD). However, results from prospective studies failed to show a consistent beneficial effect. Associations between flavan-3-ol intake and CVD risk in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) were investigated. Data were available from 24,885 (11,252 men; 13,633 women) participants, recruited between 1993 and 1997 into the EPIC-Norfolk study. Flavan-3-ol intake was assessed using 7-day food diaries and the FLAVIOLA Flavanol Food Composition database. Missing data for plasma cholesterol and vitamin C were imputed using multiple imputation. Associations between flavan-3-ol intake and blood pressure at baseline were determined using linear regression models. Associations with CVD risk were estimated using Cox regression analyses. Median intake of total flavan-3-ols was 1034mg/d (range: 0-8531mg/d) for men and 970mg/d (0-6695mg/d) for women, median intake of flavan-3-ol monomers was 233mg/d (0-3248mg/d) for men and 217 (0-2712mg/d) for women. There were no consistent associations between flavan-3-ol monomer intake and baseline systolic and diastolic blood pressure (BP). After 286,147 person-years of follow-up, there were 8463 cardiovascular events and 1987 CVD related deaths; no consistent association between flavan-3-ol intake and CVD risk (HR 0.93, 95% CI: 0.87; 1.00; Q1 vs Q5) or mortality was observed (HR 0.93, 95% CI: 0.84; 1.04). Flavan-3-ol intake in EPIC-Norfolk is not sufficient to achieve a statistically significant reduction in CVD risk. PMID:25795512

  6. 77 FR 63920 - New Jersey Transit Corporation-Acquisition Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... Surface Transportation Board New Jersey Transit Corporation--Acquisition Exemption--Norfolk Southern Railway Company The New Jersey Transit Corporation (NJ Transit), a noncarrier, has filed a verified notice..., N.J., from milepost 8.616 to milepost 9.905 (the Line). NJ Transit states that, under the...

  7. 78 FR 67216 - Norfolk Southern Railway Company-Abandonment Exemption-in Lake County, Ind.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Lake County, Ind... Munster and the City of Schererville), in Lake County, Ind. (the Line). The Line traverses United...

  8. 78 FR 41993 - Ann Arbor Railroad, Inc.-Lease Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... Surface Transportation Board Ann Arbor Railroad, Inc.--Lease Exemption--Norfolk Southern Railway Company... authority to determine whether to issue notices of exemption under 49 U.S.C. 10502 for lease and operation... for lease and operation of the rail line at issue in this case. The Board determines that this...

  9. 78 FR 40268 - Norfolk Southern Railway Company-Lease Exemption-BNSF Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... Surface Transportation Board Norfolk Southern Railway Company--Lease Exemption--BNSF Railway Company... Part 1121 for exemption from the provisions of 49 U.S.C. 11323(a)(2) to lease from BNSF Railway Company....\\1\\ \\1\\ NSR has requested expedited handling, asserting that the proposed lease and upgrade of...

  10. 75 FR 9557 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... Register (74 FR 52143) and a notice of proposed rulemaking (NPRM) entitled ``Drawbridge Operation Regulations; Elizabeth River, Eastern Branch, Norfolk, VA, in the Federal Register (74 FR 52158). We received... dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not...

  11. 75 FR 44728 - Safety Zone; Elizabeth River Private Fireworks, Elizabeth River, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Elizabeth River Private Fireworks, Elizabeth River, Norfolk, VA AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY:...

  12. 78 FR 66801 - Norfolk Southern Railway Company-Abandonment Exemption-in St. Joseph County, Ind.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in St. Joseph County... 1152 subpart F-Exempt Abandonments to abandon a total of approximately 1.5 miles of rail line located in the City of ] South Bend, St. Joseph County, Ind., extending easterly from milepost PY 1.90...

  13. 78 FR 57681 - Norfolk Southern Railway Company-Abandonment Exemption-in Polk County, Iowa

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... Surface Transportation Board Norfolk Southern Railway Company--Abandonment Exemption--in Polk County, Iowa... line segments either is pending with the Surface Transportation Board (Board) or with any U.S. District... filed by October 9, 2013, with the Surface Transportation Board, 395 E Street SW., Washington, DC...

  14. 78 FR 76382 - Notice of Cancellation of Environmental Impact Statement for the Norfolk International Airport...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ...) and hold a Public Scoping Meeting at Norfolk International Airport (Volume 66, Number 125, FR 34508..., runway safety area construction, new airfield lighting, improvements to existing lighting, relocation of the VORTAC facility, installation of a Medium Intensity Approach Lighting System with Runway...

  15. 75 FR 34367 - Safety Zone; Shore Thing & Independence Day Fireworks, Chesapeake Bay, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... Register (75 FR 26155). We received no comments on the proposed rule. No public meeting was requested, and... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Shore Thing & Independence Day Fireworks... Park, Norfolk, VA in support of the Shore Thing & Independence Day Fireworks event. This action...

  16. 76 FR 27967 - Safety Zone; Shore Thing and Independence Day Fireworks, Chesapeake Bay, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ..., 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Shore Thing and Independence Day Fireworks... View Beach Park, Norfolk, VA in support of the Shore Thing and Independence Day Fireworks event....

  17. 75 FR 26155 - Safety Zone; Shore Thing & Independence Day Fireworks, Chesapeake Bay, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Shore Thing & Independence Day Fireworks... View Beach Park, Norfolk, VA in support of the Shore Thing & Independence Day Fireworks event....

  18. New species of Nuuanu (Amphipoda: Nuuanuidae) from Norfolk Island, Torres Strait and the Cocos (Keeling) Islands.

    PubMed

    Hughes, L E; Bopiah, A

    2013-01-01

    Three new species of Nuuanu, N. quintalana sp. nov., N. stuckeyorun sp. nov. and N. titaseyi sp. nov. are described from Norfolk Island, Tasman Sea; Cocos (Keeling) Islands, Indian Ocean and the Torres Strait, Australia, respectively. There are currently 17 described species of Nuuanu with the genus distributed world-wide. PMID:26287075

  19. Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.

    PubMed

    Cox, Hannah C; Lea, Rod A; Bellis, Claire; Nyholt, Dale R; Dyer, Thomas D; Haupt, Larisa M; Charlesworth, Jac; Matovinovic, Elizabeth; Blangero, John; Griffiths, Lyn R

    2012-02-15

    Migraine is a common neurovascular disorder with a complex envirogenomic aetiology. In an effort to identify migraine susceptibility genes, we conducted a study of the isolated population of Norfolk Island, Australia. A large portion of the permanent inhabitants of Norfolk Island are descended from 18th Century English sailors involved in the infamous mutiny on the Bounty and their Polynesian consorts. In total, 600 subjects were recruited including a large pedigree of 377 individuals with lineage to the founders. All individuals were phenotyped for migraine using International Classification of Headache Disorders-II criterion. All subjects were genotyped for a genome-wide panel of microsatellite markers. Genotype and phenotype data for the pedigree were analysed using heritability and linkage methods implemented in the programme SOLAR. Follow-up association analysis was performed using the CLUMP programme. A total of 154 migraine cases (25%) were identified indicating the Norfolk Island population is high-risk for migraine. Heritability estimation of the 377-member pedigree indicated a significant genetic component for migraine (h(2)=0.53, P=0.016). Linkage analysis showed peaks on chromosome 13q33.1 (P=0.003) and chromosome 9q22.32 (P=0.008). Association analysis of the key microsatellites in the remaining 223 unrelated Norfolk Island individuals showed evidence of association, which strengthen support for the linkage findings (P≤0.05). In conclusion, a genome-wide linkage analysis and follow-up association analysis of migraine in the genetic isolate of Norfolk Island provided evidence for migraine susceptibility loci on chromosomes 9q22.22 and 13q33.1. PMID:22197687

  20. Prenatal ultrasound heating impacts on fluctuations in haematological analysis of Oryctolagus cuniculus

    PubMed Central

    Md. Dom, Sulaiman; Abdul Razak, Hairil Rashmizal; Hassan, Hamzah Fansuri

    2013-01-01

    Prenatal Ultrasound (US) is commonly used as a routine procedure on pregnant women. It is generally perceived as a safe procedure due to the use of non-ionizing radiation. However, the neurotoxicity of diagnostic prenatal US was detected to have a correlation with high susceptibility to early developing fetus. This research involved in vivo experimental model by using 3rd trimester pregnant Oryctolagus cuniculus and exposing them to US exposures for 30, 60, and 90 minutes at their gestational day (GD) 28-29. The output power and intensities, spatial peak temporal average intensity (ISPTA) of US were varied from 0.4 to 0.7 W and 0.13 to 0.19 W/cm2 respectively were tested initially in free-field, water. Haematological analysis was carried out to detect any changes in blood constituents. Statistically significant differences were detected in red blood cell (RBC) count (P<0.001), haemoglobin (Hb) concentration (P<0.001) and also platelet (PLT) count (P<0.001) in newborn of Oryctolagus cuniculus. These findings indicate the possibility of US heating in causing defects on studied animal. PMID:24273744

  1. CARETS: A prototype regional environmental information system. Volume 7: Land use information and air quality planning. [Norfolk and Portsmouth, Virginia

    NASA Technical Reports Server (NTRS)

    Alexander, R. H. (Principal Investigator); Reed, W. E.; Lewis, J. E.

    1975-01-01

    The author has identified the following significant results. The pilot air quality system provided data for updating information on the sources of point and area emissions of SO2 and particulate matter affecting the Norfolk-Portsmouth area of Virginia for 1971-72 winter and the annual 1972 period. During the 1971-72 winter, estimated SO2 amounts over an area with a SW-NE axis in the central section of Norfolk exceeded both primary and secondary levels.

  2. Spontaneous Extraskeletal Osteosarcoma in a Rabbit (Oryctolagus cuniculus): Histopathological and Immunohistochemical Findings

    PubMed Central

    Wijesundera, Kavindra Kumara; Izawa, Takeshi; Fujita, Daisuke; Denda, Yuki; Seto, Eiko; Sasai, Hiroshi; Kuwamura, Mitsuru; Yamate, Jyoji

    2013-01-01

    A spontaneously occurring subcutaneous mass in the left forelimb of a nine-year-old rabbit (Oryctolagus cuniculus) was examined histopathologically and immunohistochemically. Clinically, edema and hemorrhage were seen around the mass. No connection of the tumor mass to the appendicular skeleton was found. The tumor was arranged in a solid growth pattern and irregular bundles, and neoplastic cells were polygonal to spindle-shape. Osteoid (positive for osteocalcin) and multinucleated giant cells were diffusely or focally seen. Neoplastic cells were positive for vimentin, osterix and Ki-67, indicating the nature of osteoblasts with proliferating activity, but negative for α-smooth muscle actin, desmin or CD204. Based on these findings, a diagnosis of extraskeletal osteosarcoma was made, a very rare tumor both in laboratory and pet rabbits. PMID:24155564

  3. Factors affecting the seroprevalence of lagovirus infection in wild rabbits (Oryctolagus cuniculus) in Southern Spain.

    PubMed

    García-Bocanegra, Ignacio; Astorga, Rafael J; Napp, Sebastián; Huerta, Belén; Carbonero, Alfonso; Perea, Anselmo; Arenas, Antonio

    2011-07-01

    Cross-sectional studies were carried out on wild rabbit (Oryctolagus cuniculus) populations in Southern Spain to assess the prevalence of lagovirus infection and to identify potentially associated risk factors. A total of 619 blood and 487 liver samples from wild rabbits were collected from seven hunting areas with different Mediterranean ecosystems. Logistic regression analysis was used to assess associations between seropositivity and an extensive set of variables. The seroprevalence was 29.2% (95% CI: 25.6-32.8) and lagoviruses were not detected in liver samples. Logistic regression indicated that seropositivity to lagoviruses was associated with seropositivity to myxomatosis, wild rabbit density, the existence of artificial feeding sites, mean maximum monthly temperatures of 20-30 °C, and annual accumulated rainfall of >600 mm. PMID:20643566

  4. Seroprevalence of Encephalitozoon cuniculi and Toxoplasma gondii in domestic rabbits (Oryctolagus cuniculus) in China

    PubMed Central

    Meng, Qing-Feng; Wang, Wei-Lin; Ni, Xiao-Ting; Li, Hai-Bin; Yao, Gui-Zhe; Sun, Xiao-Lin; Wang, Wei-Li; Cong, Wei

    2015-01-01

    The breeding of domestic rabbits (Oryctolagus cuniculus) for human consumption has a long tradition in China. Infections that can affect the production of meat or even be transmitted from animals to humans are important to monitor, especially for public health reasons as well as for their impact on animal health. Thus, a total of 1,132 domestic rabbit sera from 4 regions in China were collected for serological screening for Encephalitozoon cuniculi and for Toxoplasma gondii by ELISA and modified agglutination test (MAT), respectively. Antibodies to E. cuniculi were detected in 248/1,132 (21.9%) sera tested while antibodies against T. gondii revealed a seroprevalence of 51/1,132 (4.5%). We believe that the present results are of epidemiological implications and public health importance due to the acknowledged susceptibility of humans to E. cuniculi and T. gondii infections. Therefore, routine screening tests of domestic rabbits are proposed considering the zoonotic potential of these parasites. PMID:26797446

  5. 76 FR 38300 - Safety Zone; Shore Thing and Independence Day Fireworks, Chesapeake Bay, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ...The Coast Guard is establishing a temporary safety zone on the Chesapeake Bay in the vicinity of Ocean View Beach Park, Norfolk, VA in support of the Shore Thing and Independence Day Fireworks event. This action is necessary to provide for the safety of life on navigable waters during the Shore Thing and Independence Day Fireworks show. This action is intended to restrict vessel traffic......

  6. Linkage Mapping of CVD Risk Traits in the Isolated Norfolk Island Population

    PubMed Central

    Bellis, C.; Cox, H.C; Dyer, T. D.; Charlesworth, J. C.; Begley, K.N; Quinlan, S.; Lea, R.A; Heath, S.C; Blangero, J.; Griffiths, L.R

    2009-01-01

    To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377 individuals from the Norfolk Island population. The central aim of this research focused on the utilization of a genetically and geographically isolated population of individuals from Norfolk Island for the purposes of variance component linkage analysis to identify QTLs involved in CVD risk traits. Substantial evidence supports the involvement of traits such as systolic and diastolic blood pressures (SBP and DBP), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and triglycerides (TG) as important risk factors for CVD pathogenesis. In addition to the environmental influences of poor diet, reduced physical activity, increasing age, cigarette smoking and alcohol consumption, many studies have illustrated a strong involvement of genetic components in the CVD phenotype through family and twin studies. We undertook a genome scan using 400 markers spaced approximately 10cM in 600 individuals from Norfolk Island. Genotype data was analyzed using the variance components methods of SOLAR. Our results gave a peak LOD score of 2.01 localizing to chromosome 1p36 for systolic blood pressure and replicated previously implicated loci for other CVD relevant QTLs. PMID:18975005

  7. Neogene-Quaternary depositional history of the eastern US continental rise seaward of the Washington-Norfolk Canyon systems

    SciTech Connect

    Locker, S.D.; Laine, E.P.

    1985-01-01

    High quality, digitally recorded and processed, water gun and air gun seismic reflection data collected seaward of the present position of the Washington-Norfolk canyon systems reveals new information on the development of the continental rise. This includes insight into the depositional history of the Washington-Norfolk fan system and the relative importance of gravity flow depositional processes versus abyssal bottom current reworking during rise development. Three major post-Horizon A/sup u/ accretionary sequences describe major changes in depositional processes and history within the region. Accretionary sequence I (early to middle Miocene) is characterized by the initial development of a depositional bulge seaward of the Washington-Norfolk canyon systems which is modified by bottom currents on the lower-most rise to form a proto-Hatteras Outer Ridge. The predominance of chaotic and hummocky seismic facies suggests widespread reworking by abyssal bottom currents. Accretionary sequence II (middle Miocene to late Pliocene) in this area is characterized by sediment waves (lower rise) and smooth, southward dipping, parallel reflectors associated with a thick central rise drift(.) deposit off the Hudson system to the North. Washington-Norfolk fan development appears less important during this time. Bottom currents are active, but more depositional in nature than during accretionary sequence I. Accretionary sequence III (late Pliocene to Present) is marked by gravity flow processes and distinct development of the Washington-Norfolk fan on the central rise.

  8. Could wild rabbits (Oryctolagus cuniculus) be reservoirs for Leishmania infantum in the focus of Madrid, Spain?

    PubMed

    Jiménez, Maribel; González, Estela; Martín-Martín, Inés; Hernández, Sonia; Molina, Ricardo

    2014-05-28

    Xenodiagnosis has previously proved that hares (Lepus granatensis) from a focus of leishmaniasis in the southwestern Madrid region (Spain) are infective to Phlebotomus perniciosus, the only vector in the area, thus playing a probable role as active reservoirs in a sylvatic transmission cycle linked to the usual domestic one. Although actions have been taken to reduce the population of this lagomorph, a high population of wild rabbits (Oryctolagus cuniculus) is present in the area, which shows detectable anti-Leishmania infantum antibodies and a large number of individuals with DNA of this parasite. With the aim to elucidate the role of this lagomorph in the focus, xenodiagnostic studies carried out with wild rabbits captured in the area demonstrate that they are able to transmit L. infantum to P. perniciosus. Moreover, the study of blood meal preferences of P. perniciosus caught in the focus during and entomological survey shows strong evidence that rabbits are contributing to the maintenance of a high sand fly population in the area. These findings suggest that wild rabbits could play some role in Leishmania transmission. PMID:24774435

  9. Evidence of Leishmania infantum infection in rabbits (Oryctolagus cuniculus) in a natural area in Madrid, Spain.

    PubMed

    García, Nerea; Moreno, Inmaculada; Alvarez, Julio; de la Cruz, María Luisa; Navarro, Alejandro; Pérez-Sancho, Marta; García-Seco, Teresa; Rodríguez-Bertos, Antonio; Conty, María Luisa; Toraño, Alfredo; Prieto, Antonio; Domínguez, Lucas; Domínguez, Mercedes

    2014-01-01

    Leishmaniasis is one of the most important neglected zoonosis and remains endemic in at least 88 developing countries in the world. In addition, anthropogenic environmental changes in urban areas are leading to its emergency world wide. Zoonotic leishmaniasis control might only be achieved by an integrated approach targeting both the human host and the animal reservoirs, which in certain sylvatic cycles are yet to be identified. Recently, hares have been pointed out as competent reservoirs of Leishmania infantum in Spain, but the role of other lagomorphs has not been clarified. Here, 69 rabbits (Oryctolagus cuniculus) from a natural area in Madrid in which a high density was present were analyzed using indirect (immunofluorescence antibody test, IFAT) and direct (PCR, culture) techniques. Fifty-seven (82.6%) of the animals were positive to at least one technique, with IFAT yielding the highest proportion of positive samples. L. infantum was isolated in 13% animals demonstrating the occurrence of infection in this setting. Our results suggest that rabbits could play a role of competent reservoir of L. infantum and demonstrate that the prevalence of infection is high in the analyzed area. PMID:24724079

  10. Evidence of Leishmania infantum Infection in Rabbits (Oryctolagus cuniculus) in a Natural Area in Madrid, Spain

    PubMed Central

    Navarro, Alejandro; Pérez-Sancho, Marta; García-Seco, Teresa; Rodríguez-Bertos, Antonio; Conty, María Luisa; Toraño, Alfredo; Prieto, Antonio; Domínguez, Lucas; Domínguez, Mercedes

    2014-01-01

    Leishmaniasis is one of the most important neglected zoonosis and remains endemic in at least 88 developing countries in the world. In addition, anthropogenic environmental changes in urban areas are leading to its emergency world wide. Zoonotic leishmaniasis control might only be achieved by an integrated approach targeting both the human host and the animal reservoirs, which in certain sylvatic cycles are yet to be identified. Recently, hares have been pointed out as competent reservoirs of Leishmania infantum in Spain, but the role of other lagomorphs has not been clarified. Here, 69 rabbits (Oryctolagus cuniculus) from a natural area in Madrid in which a high density was present were analyzed using indirect (immunofluorescence antibody test, IFAT) and direct (PCR, culture) techniques. Fifty-seven (82.6%) of the animals were positive to at least one technique, with IFAT yielding the highest proportion of positive samples. L. infantum was isolated in 13% animals demonstrating the occurrence of infection in this setting. Our results suggest that rabbits could play a role of competent reservoir of L. infantum and demonstrate that the prevalence of infection is high in the analyzed area. PMID:24724079

  11. Experimental Infection of New Zealand White Rabbits (Oryctolagus cuniculi) with Leporid herpesvirus 4

    PubMed Central

    Sunohara-Neilson, Janet R; Brash, Marina; Carman, Susy; Nagy, Éva; Turner, Patricia V

    2013-01-01

    Leporid herpesvirus 4 (LHV4) is a novel alphaherpesvirus recently identified in domestic rabbits (Oryctolagus cuniculi). Little is known about the pathogenesis or time course of disease induced by this virus. We therefore intranasally inoculated 22 female New Zealand white rabbits with 8.4 × 104 CCID50 of a clinical viral isolate. Rabbits were monitored for clinical signs, viral shedding in oculonasal secretions, and development and persistence of serum antibodies. Rabbits were euthanized at 3, 5, 7, 14, and 22 d postinfection (dpi) to evaluate gross and microscopic changes. Clinical signs were apparent between 3 to 8 dpi, and included oculonasal discharge, respiratory distress, and reduced appetite, and viral shedding occurred between 2 and 8 dpi. Seroconversion was seen at 11 dpi and persisted to the end of the study (day 22). Severe necrohemorrhagic bronchopneumonia and marked pulmonary edema were noted by 5 dpi and were most severe at 7 dpi. Pulmonary changes largely resolved by 22 dpi. In addition, multifocal splenic necrosis was present at 5 dpi and progressed to submassive necrosis by 7 dpi. Eosinophilic herpesviral intranuclear inclusion bodies were detected in the nasal mucosa, skin, spleen, and lung between 3 to 14 dpi. LHV4 is a pathogen that should be considered for rabbits that present with acute respiratory disease. LHV4 infection can be diagnosed based on characteristic microscopic changes in the lungs and spleen and by virus isolation. Serum antibody levels may be used to monitor viral prevalence in colonies. PMID:24210019

  12. Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus)

    PubMed Central

    Campos, R; Storz, J F; Ferrand, N

    2012-01-01

    Comparative genomic studies have revealed that mammals typically possess two or more tandemly duplicated copies of the α-globin (HBA) gene. The domestic rabbit represents an exception to this general rule, as this species was found to possess a single HBA gene. Previous electrophoretic surveys of HBA polymorphism in natural populations of the European rabbit (Oryctolagus cuniculus) revealed extensive geographic variation in the frequencies of three main electromorphs. The variation in frequency of two electromorphs is mainly partitioned between two distinct subspecies of European rabbit, and a third is restricted to the hybrid zone between the two rabbit subspecies in Iberia. Here we report the results of a survey of nucleotide polymorphism, which revealed HBA copy number polymorphism in Iberian populations of the European rabbit. By characterizing patterns of HBA polymorphism in populations from the native range of the European rabbit, we were able to identify the specific amino-acid substitutions that distinguish the previously characterized electromorphs. Within the hybrid zone, we observed the existence of a second HBA gene duplicate, named HBA2, that mostly represents a novel sequence haplotype, which occurs in higher frequency within the hybrid zone, and thus appears to have arisen in hybrids of the two distinct subspecies. Although this novel gene is also present in other wild Iberian populations, it is almost absent from French populations, which suggest a recent ancestry, associated with the establishment of the post-Pleistocene contact zone between the two European rabbit subspecies. PMID:22146981

  13. Enzymatic Modification of Soluble Cyanophycin Using the Type II Peptidyl Arginine Deiminase from Oryctolagus cuniculus.

    PubMed

    Wiefel, Lars; Steinbüchel, Alexander

    2016-07-01

    An increased structural variety expands the number of putative applications for cyanophycin (multi-l-arginyl-poly-[l-aspartic acid], CGP). Therefore, structural modifications of CGP are of major interest; these are commonly obtained by modification and optimization of the bacterial producing strain or by chemical modification. In this study, an enzymatic modification of arginine side chains from lysine-rich CGP is demonstrated using the peptidyl arginine deiminase from Oryctolagus cuniculus, purified from Escherichia coli after heterologous expression. About 10% of the arginine side chains are converted to citrulline which corresponds to 4% of the polymer's total side chains. An inhibition of the reaction in the presence of small amounts of l-citrulline is observed, thereby explaining the low conversion rate. CGP dipeptides can be modified with about 7.5 mol% of the Asp-Arg dipeptides being converted to Asp-Cit. These results show that the enzymatic modification of CGP is feasible, opening up a whole new area of possible CGP modifications for further research. PMID:26953800

  14. Neuropathological observation of rabbits (Oryctolagus cuniculus) affected with raccoon roundworm (Baylisascaris procyonis) larva migrans in Japan.

    PubMed

    Furuoka, Hidefumi; Sato, Hiroshi; Kubo, Midori; Owaki, Shigeo; Kobayashi, Yoshiyasu; Matsui, Takane; Kamiya, Haruo

    2003-06-01

    Larvae of the raccoon roundworm, Baylisascaris procyonis (B. procyonis) are a known cause of cerebrospinal larva migrans in animals and humans. The present paper described details of the central nervous lesion in the rabbits (Oryctolagus cuniculus) affected with B. procyonis larva migrans in Japan. Clinically affected animals showed neurological signs including circling, torticollis, tremor of head, or ataxic gait. The most characteristic pathological alterations were large malacic lesions associated with an activated astroglial proliferation which was seen at the corpus medullare in the cerebellum including the cerebellar peduncle. Moreover, focal malacic lesions with perivascular cuffing and infiltration by lymphocytes and heterophiles were scattered everywhere throughout the brain. In these lesions or normal-appearing areas away from obvious lesions, ascarid larvae, about a maximum 65-75 micro m in diameter, were recognized. Other prominent features were minute lesions (we call them migration tract-like lesions) composed of lymphocytes, hemosiderin-laden macrophages and reactive astrocytes scattering throughout the cerebrum. In this study, we demonstrated ascarid larvae in only eight out of 23 animals diagnosed as B. procyonis larva migrans. Since it is not always possible to detect the larvae, the possibility of B. procyonis larva migrans must be given serious consideration to the characteristic lesions described above. PMID:12867729

  15. Computational identification and microarray-based validation of microRNAs in Oryctolagus cuniculus.

    PubMed

    Liu, Guiming; Fang, Yongjun; Zhang, Hongming; Li, Yan; Li, Xingang; Yu, Jun; Wang, Xumin

    2010-10-01

    MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that play important roles in complex biological processes through degradation of target mRNAs or repression of their translation. We exploited cross-species comparison to predict miRNAs and identified 266 genes encoding 274 mature miRNAs in Oryctolagus cuniculus. Comparative analyses among mammalian genomes demonstrated that most of the identified miRNAs and their clusters are ancient in origin and conserved among mammals but a few clades as well as some species-specific miRNAs exhibit an ongoing evolutionary process where gain and loss of individual miRNAs have occurred through tandem duplications and random mutations. Our microarray- and RT-PCR-based analyses and target prediction reveal specific expression patterns in brain, spleen, muscle, heart, and ovary, and significant over-representations in certain GO categories as regarded to their mRNA targets include genes that play key roles in signal transduction and transcriptional regulation. PMID:20213505

  16. Comparison of side effects between buprenorphine and meloxicam used postoperatively in Dutch belted rabbits (Oryctolagus cuniculus).

    PubMed

    Cooper, Coreen S; Metcalf-Pate, Kelly A; Barat, Christopher E; Cook, Judith A; Scorpio, Diana G

    2009-05-01

    One of the challenges facing veterinarians and investigators who use rabbits (Oryctolagus cuniculus) as a surgical model in biomedical research is choosing an appropriate and efficacious postoperative analgesic without systemic complications and side effects. The objective of this study was to evaluate the gastrointestinal side effects associated with the postoperative use of buprenorphine in Dutch Belted rabbits. We also evaluated the analgesic meloxicam as an alternative to opioid administration during the postoperative period. Rabbits were assigned to 1 of 3 treatment groups during the postoperative period after routine ovariohysterectomy: buprenorphine (n = 10), meloxicam (n = 10), and incisional infiltration with bupivicaine (no treatment control; n = 10). Feed intake, fecal production, weight loss, urine output, and other physiologic parameters were monitored and behavior and pain assessments were performed for 7 d after surgery and compared with baseline values collected before surgery. All rabbits showed decreased pellet consumption, fecal production, and weight on day 1 after surgery. This effect was severe in some rabbits that received bupivicaine; therefore treatment of this entire group with metoclopramide, fluids, and hay was instituted to reverse gut stasis. No significant difference in feed consumption and fecal production was present between the buprenorphine- and meloxicam-treated groups. On the basis of these results, meloxicam appears to be a suitable alternative or adjunct to buprenorphine for alleviating postoperative pain with minimal risk of anorexia and gastrointestinal ileus. PMID:19476717

  17. A case of interscapular fibrosarcoma in a dwarf rabbit (Oryctolagus cuniculus).

    PubMed

    Petterino, Claudio; Modesto, Paola; Strata, Daniela; Vascellari, Marta; Mutinelli, Franco; Ferrari, Angelo; Ratto, Alessandra

    2009-11-01

    A 1-year-old, intact, male dwarf rabbit (Oryctolagus cuniculus) was vaccinated against myxomatosis and rabbit viral hemorrhagic disease in February 1999, and a localized reaction appeared in the same anatomic site within a few days. No regression was observed after subcutaneous antibiotic treatment. The rabbit was kept under observation, and the swelling apparently disappeared in 3 months. The owner then decided to avoid any further subcutaneous drug administration. The referring veterinarian examined the animal on July 2006 for the sudden appearance of a nodular, 4.5 cm x 3.5 cm x 2.0 cm, subcutaneous mass located over the interscapular space. Fine-needle aspiration was performed, and a population of neoplastic spindle cells, rare pleomorphic multinucleated cells, and rare leukocytes were observed. The mass was surgically removed, fixed in 10% neutral buffered formalin, and routinely processed for histologic, histochemical, and immunohistochemical diagnostic investigation. The neoplastic tissue exhibited fascicles composed of malignant spindle-shaped cells with elongated to oval hyperchromatic nuclei and scant cytoplasm. Occasional multinucleated cells were also observed. The neoplastic cells were immunoreactive for vimentin but did not stain for smooth muscle actin, desmin, myoglobin, and cytokeratins (AE1/AE3). Moreover, the histochemical stain for aluminum was positive. The diagnosis was fibrosarcoma based on morphologic and immunohistochemical results. The histologic features of this neoplasm were remarkably similar to feline injection-site sarcoma. PMID:19901300

  18. Vaccination of free-living juvenile wild rabbits (Oryctolagus cuniculus) against myxomatosis improved their survival.

    PubMed

    Guitton, Jean-Sébastien; Devillard, Sébastien; Guénézan, Michel; Fouchet, David; Pontier, Dominique; Marchandeau, Stéphane

    2008-04-17

    For several decades, the populations of the European wild rabbit (Oryctolagus cuniculus) have declined, which is partly due to myxomatosis. Vaccination against this disease is expected to contribute to restoration of rabbit populations but the actual impact of myxomatosis is not well known and vaccination might have some negative effects. We analyzed the capture-mark-recapture data obtained in a 4-year field experiment (1991-1994) in a park near Paris, France wherein 300 out of 565 seronegative juvenile rabbits were vaccinated at first capture against myxomatosis with the nontransmissible Dervaximyxo SG33 vaccine. After accounting for weight at first capture, age-class (juvenile/adult), "trap-happiness" and season (spring/autumn) of the capture event, vaccinated rabbits had 1.8-fold greater odds of surviving than the unvaccinated rabbits. The average summer survival risk for vaccinated juveniles was 0.63 (+/-0.08 S.E.) whereas it was 0.48 (+/-0.08 S.E.) for unvaccinated juvenile rabbits. PMID:18045714

  19. An individual-based model of rabbit viral haemorrhagic disease on European wild rabbits (Oryctolagus cuniculus)

    USGS Publications Warehouse

    Fa, John E.; Sharples, Colin M.; Bell, Diana J.; DeAngelis, Donald L.

    2001-01-01

    We developed an individual-based model of Rabbit Viral Hemorrhagic Disease (RVHD) for European wild rabbits (Oryctolagus cuniculus L.), representing up to 1000 rabbits in four hectares. Model output for productivity and recruitment matched published values. The disease was density-dependent and virulence affected outcome. Strains that caused death after several days produced greater overall mortality than strains in which rabbits either died or recovered very quickly. Disease effect also depended on time of year. We also elaborated a larger scale model representing 25 km2 and 100,000+ rabbits, split into a number of grid-squares. This was a more traditional model that did not represent individual rabbits, but employed a system of dynamic equations for each grid-square. Disease spread depended on probability of transmission between neighboring grid-squares. Potential recovery from a major population crash caused by the disease relied on disease virulence and frequency of recurrence. The model's dependence on probability of disease transmission between grid-squares suggests the way that the model represents the spatial distribution of the population affects simulation. Although data on RVHD in Europe are lacking, our models provide a basis for describing the disease in realistic detail and for assessing influence of various social and spatial factors on spread.

  20. Pollution prevention opportunity assessment United States Naval Base Norfolk Naval Air Station. Project summary

    SciTech Connect

    Bowman, D.; DeWaters, J.

    1995-09-01

    The purposes of the WREAFS Program are to identify new technologies and techniques for reducing wastes from process operations and other activities at Federal sites, and to enhance the implementation of pollution prevention/waste minimization through technology transfer. New techniques and technologies for reducing waste generation are identified through waste minimization opportunity assessments and may be further evaluated through joint research, development, and demonstration projects. A cooling tower is an enclosed device designed for the evaporative cooling of water by direct contact with air. Cooling towers are used in conjunction with air conditioning and industrial process equipment, acting as the heat sink for these systems by providing a continuous source of cool water for process operations. Open-system recirculating cooling towers are typically chosen for operation with air conditioning and refrigeration equipment because they are relatively inexpensive and minimize heat rejection costs while conserving water. All of the cooling towers at the Norfolk Naval Air Station identified in this PPOA are of the recirculating, open-system type. The Navy and EPA are currently evaluating techniques and technologies to reduce wastes generated from cooling tower operations within the Norfolk NAS. Approximately 28 open-system recirculating cooling towers are currently operated at 18 buildings within the NAS. These units range in size from 5 to 300 tons, and are all associated with comfort cooling systems that operate on a seasonal basis (approximately 6 mo/yr).

  1. Endemics and adventives: Thysanoptera (Insecta) biodiversity of Norfolk, a tiny Pacific Island.

    PubMed

    Mound, Laurence A; Wells, Alice

    2015-01-01

    The thrips fauna of Norfolk Island is a curious mix of endemics and adventives, with notable absences that include one major trophic group. A brief introduction is provided to the history of human settlement and its ecological impact on this tiny land mass in the western Pacific Ocean. The Thysanoptera fauna comprises about 20% endemic and almost 50% widespread invasive species, and shows limited faunal relationships to the nearest territories, Australia, New Caledonia and New Zealand. This fauna, comprising 66 species, includes among named species 29 Terebrantia and 33 Tubulifera, with four Tubulifera remaining undescribed. At least 12 species are endemics, of which 10 are mycophagous, and up to 10 further species are possibly native to the island. As with the thrips fauna of most Pacific islands, many species are widespread invasives. However, most of the common thrips of eastern Australia have not been found on Norfolk Island, and the complete absence of leaf-feeding Phlaeothripinae is notable. The following new taxa are described: in the Phlaeothripidae, Buffettithrips rauti gen. et sp. n. and Priesneria akestra sp. n.; and in the Thripidae, Scirtothrips araucariae sp. n. and Thrips merae sp. n. PMID:26249431

  2. 77 FR 58909 - Norfolk Southern Railway Company-Abandonment and Discontinuance of Service Exemption-In Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... Exemption--In Lake County, Ind., and Cook County, Ill. Norfolk Southern Railway Company (NSR) has filed a... Lake County, Ind., and Cook County, Ill., and to discontinue service over a contiguous line segment of approximately 1.2 miles (the Western Line Segment) located in Cook County, Ill.\\1\\ The roughly 6.30-mile...

  3. 76 FR 42163 - East Penn Railroad, L.L.C.; Lease and Operation Exemption; Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Surface Transportation Board East Penn Railroad, L.L.C.; Lease and Operation Exemption; Norfolk Southern... delegated the authority to determine whether to issue notices of exemption for lease transactions under 49 U... has determined that this lease and operation notice of exemption should be issued, and does so...

  4. 77 FR 43557 - Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ...The Coast Guard proposes establishing a safety zone on the navigable waters of the Elizabeth River in Norfolk, Portsmouth, and Chesapeake, VA. This action is necessary to provide for the safety of life on navigable waters during the Gilmerton Bridge Center Span Float- in and bridge construction of span placement. This action is intended to restrict vessel traffic movement to protect mariners......

  5. 77 FR 44544 - Safety Zone; Gilmerton Bridge Center Span Float-In, Elizabeth River; Norfolk, Portsmouth, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Gilmerton Bridge Center Span Float-In... notice of proposed rulemaking entitled ``Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and Chesapeake, Virginia'' in the Federal Register (77 FR 43557)....

  6. The Norfolk Decision: The Effects of Converting from a Unitary Educational System to a Dual Educational System upon Academic Achievement.

    ERIC Educational Resources Information Center

    Ikpa, Vivian W.

    As a means of achieving a unitary school system, a mandated busing policy was implemented by the Norfolk, Virginia, public school system in 1986. This study examined the extent to which individual characteristics, school characteristics, and busing affected the student achievement gap between the busing and postbusing years. Methodology involved…

  7. 75 FR 61817 - Jackson & Lansing Railroad Company-Lease and Operation Exemption-Norfolk Southern Railway Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Surface Transportation Board Jackson & Lansing Railroad Company--Lease and Operation Exemption--Norfolk Southern Railway Company Under 49 CFR 1011.7(b)(10), the Director of the Office of Proceedings (Director... & Lansing Railroad Company (JAIL), a noncarrier, has filed a verified notice of exemption under 49 CFR...

  8. 76 FR 65319 - Norfolk Southern Railway Company-Discontinuance of Service Exemption-in Forsyth County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... Surface Transportation Board Norfolk Southern Railway Company--Discontinuance of Service Exemption--in... over approximately 10.0 miles of rail line between mileposts L-0.0 (near Trade Street in Winston-Salem) and L-10.0 (near the intersection of Hampton Road and Idols Road in Clemmons), in Forsyth County,...

  9. Sarcocystis and related organisms in Australian Wildlife: IV. Studies on Sarcocystis cuniculi in European rabbits (Oryctolagus cuniculus).

    PubMed

    Munday, B L; Smith, D D; Frenkel, J K

    1980-04-01

    The role of the cat (Felis domestica) as a definitive host for Sarcocystis cuniculi of European rabbits (Oryctolagus cuniculus) was confirmed. It was shown that after dosing with sporocysts from cats, rabbits developed sarcocysts and these became infective for cats at not less than 93 days post-infection (p.i.). The earliest infection detected was at 142 days p.i. Infected muscle from an experimental rabbit did not transmit Sarcocystis when fed to other rabbits. Microscopically, sarcocysts in European rabbits (O. cuniculus) were morphologically indistinguishable from those in cottontail rabbits (Sylvilagus floridanus). PMID:6776293

  10. Measuring Rabbit (Oryctolagus cuniculus) Tooth Growth and Eruption by Fluorescence Markers and Bur Marks.

    PubMed

    Wyss, Fabia; Müller, Jacqueline; Clauss, Marcus; Kircher, Patrick; Geyer, Hans; von Rechenberg, Brigitte; Hatt, Jean-Michel

    2016-03-01

    Rabbits (Oryctolagus cuniculus) and rodents possess continuously growing teeth, and dental problems are a major health issue in these species. Knowledge of tooth growth characteristics is required to adequately treat dental problems and advise owners concerning diets. Most research was performed using bur marks and measuring eruption and wear manually. However, this method cannot be applied to teeth less rostral than the first premolar; therefore, for evaluation of molars, other methods are needed. We evaluated the use of fluorochromes xylenol orange and calcein green to measure growth rates of rabbit teeth and compared this method to results obtained by manually measuring the distance between a bur mark and the gingival margin of the same tooth (eruption) and by measuring the distance between the bur mark and the apex of the same tooth on computed tomography scans (growth). Apical fluorochrome measurements correlated well with eruption and growth rates obtained with bur marks, whereas measurements coronal to the pulp cavity did not. Growth rates were approximately 1.9 mm/wk for maxillary and 2.2 mm/wk for mandibular incisors. Growth rates of premolars were 2.14 ± 0.28 mm/wk in rabbits on a grass/rice hulls/sand pelleted diet and 0.93 ± 0.18 mm/wk in rabbits on a hay diet. Growth of molars could only be assessed using the measurement in dentin on the wall of the pulp cavity, which does not account for the real growth. However, being similar to this measurement in premolars, one could hypothesize similar growth in molars as in premolars. We conclude that the application of fluorochrome staining can be used to measure tooth growth in teeth that are not accessible for bur marks or in animals that are too small to assess tooth eruption or growth by bur marks. PMID:27487654

  11. Strontium calcium phosphate for the repair of leporine (Oryctolagus cuniculus) ulna segmental defect.

    PubMed

    Mohan, Beena G; Shenoy, Sachin J; Babu, Suresh S; Varma, H K; John, Annie

    2013-01-01

    Scaffolds to aid in repair, replacement, or regeneration of bony tissues have been developed using a wide spectra of materials. Under clinical conditions, assessment of healing and implant placement is guided radiographically. In this context, strontium's role in osteostimulation and its relevance in radio-opacity are known. Therefore to aid in assessment and to ensure tissue regeneration, a bone mimetic porous strontium calcium phosphate (SrCaPO(4) ) was synthesized in-house, which was non-cytotoxic (ISO 10993 (Part V) and subsequently characterized for its crystallinity, functional groups, and 3D porous topography. Furthermore, to assess the feasibility of the bioactive ceramic scaffolds in bone repair, SrCaPO(4) and hydroxyapatite (HA-Control) scaffolds were implanted in the segmental ulna bone critical-sized defect (1.5 cm) of New Zealand White Rabbits (leporine model-Oryctolagus cuniculus) for a period of 4 and 12 weeks, respectively. Healing of the defects was uneventful without any inflammation or infection. Radio-opacity of SrCaPO(4) within the defect site enabled easy assessment of implant placement and osteointegration. Again, histological evaluation coupled with micro-CT and histomorphometrical analysis indicated that SrCaPO(4) favored significant de novo bone formation in par with material degradation at 4 and 12 weeks post-implantation compared to HA at 4 and 12 weeks. Investigations on this radio-opaque SrCaPO(4) established its role in the repair of critical-sized segmental defects, proposing it as a suitable bone substitute for clinical reconstructive surgery with easy radiographic evaluation. PMID:22941787

  12. Organic matter and macromineral digestibility in domestic rabbits (Oryctolagus cuniculus) as compared to other hindgut fermenters.

    PubMed

    Hagen, K B; Tschudin, A; Liesegang, A; Hatt, J-M; Clauss, M

    2015-12-01

    It is generally assumed that animal species differ in physiological characteristics of their digestive tract. Because investigating digestive processes is often labour-intensive, requiring lengthy adaptation and collection periods, comparisons are often made on the basis of data collated from different studies. We added a new data set on dietary crude fibre (CF) and macromineral (Na, K, Ca, P, Mg) composition and apparent digestibility (aD) of organic matter (OM) and macrominerals in rabbits (Oryctolagus cuniculus; a total of 180 measurements with 12 individuals and 10 different diets) to a literature data collection for rodents and domestic horses (Equus caballus). Significant negative relationships between dietary CF and aD OM were obtained, but the significant difference in digestive efficiency between rabbits and guinea pigs (Cavia porcellus) reported from studies where both species had been investigated under identical conditions were not detectable in the larger data collection. However, the 95% confidence interval of the negative slope of the CF-aD OM relationship did not overlap between domestic horses on the one hand, and rabbits and guinea pigs on the other hand, indicating a less depressing effect of CF in horses. Akaike's information criterion indicated that aD of a macromineral did not only depend on its concentration in the diet, but also on the individual and various other diet characteristics and the presence of other macrominerals, indicating complex interactions. The data indicate similar mechanisms in the absorption of macrominerals amongst rabbits, rodents and horses, with the exception of Na and K in guinea pigs and Ca in chinchillas (Chinchilla laniger) that should be further corroborated. In particular, the occurrence of high aD Ca in hindgut fermenters, regardless of whether they employ a digestive strategy of coprophagy or whether they have fossorial habits, suggests that this peculiarity might represent an adaptation to hindgut

  13. Widespread exposure to Sarcoptes scabiei in wild European rabbits (Oryctolagus cuniculus) in Spain.

    PubMed

    Millán, J; Casáis, R; Delibes-Mateos, M; Calvete, C; Rouco, C; Castro, F; Colomar, V; Casas-Díaz, E; Ramírez, E; Moreno, S; Prieto, J M; Villafuerte, R

    2012-02-10

    Sarcoptic mange was recently described in the wild European rabbit (Oryctolagus cuniculus) in north-eastern Mediterranean Spain, the first such infection reported in this species anywhere in the world. This finding has created concern in conservationists and game managers given that an outbreak of mange after a translocation would have catastrophic consequences for naïve rabbit populations in other parts of Spain. A retrospective serosurvey using an 'in house' ELISA test based on the use of a recombinant antigen aimed at determining the rates of contact with Sarcoptes scabiei was carried out on sera from 966 rabbits collected between 1993 and 2010 in Spain. Antibodies were found in 13% of wild rabbits in 60% of the 53 areas surveyed, as well as in 16 of the 17 Spanish provinces and islands studied. Seropositive rabbits were found amongst the oldest samples analyzed and in all studied years. Antibodies were also detected in 36% of rabbits from the protected island of Dragonera, where rabbits have probably not been released since the 1970s. On Mallorca, where 89 rabbits were inspected for both lesions and antibodies, the prevalence of lesions (5.6%) was much lower than the seroprevalence (22.5%), indicating that rabbits often survive infection or that ELISA detects infected rabbits before they develop visible lesions. Seroprevalence was higher in areas with medium levels of rabbit abundance, no restocking and high rainfall. The results show that mange is widespread in rabbits and that the mite is not a recent introduction. Thus, sarcoptic mange could be considered as an enzootic disease in the wild rabbit and so prophylactic measures implemented during rabbit translocations are to be encouraged to avoid local outbreaks in naïve populations. PMID:21852039

  14. Evidence for Widespread Positive and Purifying Selection Across the European Rabbit (Oryctolagus cuniculus) Genome

    PubMed Central

    Carneiro, Miguel; Albert, Frank W.; Melo-Ferreira, José; Galtier, Nicolas; Gayral, Philippe; Blanco-Aguiar, Jose A.; Villafuerte, Rafael; Nachman, Michael W.; Ferrand, Nuno

    2012-01-01

    The nearly neutral theory of molecular evolution predicts that the efficacy of both positive and purifying selection is a function of the long-term effective population size (Ne) of a species. Under this theory, the efficacy of natural selection should increase with Ne. Here, we tested this simple prediction by surveying ∼1.5 to 1.8 Mb of protein coding sequence in the two subspecies of the European rabbit (Oryctolagus cuniculus algirus and O. c. cuniculus), a mammal species characterized by high levels of nucleotide diversity and Ne estimates for each subspecies on the order of 1 × 106. When the segregation of slightly deleterious mutations and demographic effects were taken into account, we inferred that >60% of amino acid substitutions on the autosomes were driven to fixation by positive selection. Moreover, we inferred that a small fraction of new amino acid mutations (<4%) are effectively neutral (defined as 0 < Nes < 1) and that this fraction was negatively correlated with a gene’s expression level. Consistent with models of recurrent adaptive evolution, we detected a negative correlation between levels of synonymous site polymorphism and the rate of protein evolution, although the correlation was weak and nonsignificant. No systematic X chromosome–autosome difference was found in the efficacy of selection. For example, the proportion of adaptive substitutions was significantly higher on the X chromosome compared with the autosomes in O. c. algirus but not in O. c. cuniculus. Our findings support widespread positive and purifying selection in rabbits and add to a growing list of examples suggesting that differences in Ne among taxa play a substantial role in determining rates and patterns of protein evolution. PMID:22319161

  15. Potential geothermal energy use at the Naval Air Rework Facilities, Norfolk, Virginia and Jacksonville, Florida, and at the naval shipyard, Charleston, South Carolina

    SciTech Connect

    Costain, J.K.; Glover, L. III; Newman, R.W.

    1984-05-01

    The feasibility of geothermal energy use at naval installations in Norfolk, VA, Jacksonville, FL, and Charleston, SC was assessed. Geophysical and geological studies of the above areas were performed. Engineering and economic factors, affecting potential energy use, were evaluated. The Norfolk and Jacksonville facilities are identified as candidates for geothermal systems. System costs are predicted. Economic benefits of the proposed geothermal systems are forecast, using the net present value method of predicting future income.

  16. Shoreline responses to storm impacts: North Norfolk coast, southern North Sea

    NASA Astrophysics Data System (ADS)

    Brooks, Sue; Spencer, Thomas

    2016-04-01

    Recent phases of enhanced mid-latitude storminess (e.g. NW European winter of 2013 - 14) have led to a growing awareness of the considerable impacts of storms on coastal landscapes and their communities. Using aerial photography, bi-annual cross-shore profiles, detailed alongshore ground survey, and offshore/inshore wave buoy and regional tide gauge datasets, this paper considers storm impacts on the barrier coastline of North Norfolk, UK. Firstly, at Scolt Head Island, we show that the barrier dune crest has been progressively set back landwards since 2006 in three storm-related phases, with each shoreline translation being of the order of 5-8 m. However, a fourth storm produced no significant shoreline change, demonstrating that the threshold for morphological change is a function of the combined effects of still water level and wave height at the shore, the magnitude and duration of these components, and the timing of their interaction. Secondly, we consider recovery times in the system against periods of quiescence and heightened storm activity on this coast. Thirdly, it has been argued that future changes in extreme water level will be governed by mean sea level rise. Long-term rates of North Norfolk barrier retreat (1.15 m a-1, 1891-2013) have occurred under a regional rate of relative sea level rise over the 20th century of 2.7 ± 0.4 mm a-1 (Lowestoft tide gauge, 1900-2014). If there is a broad correlation between rates of barrier retreat and sea level rise, then recent increases in the rate of regional sea level rise (4.4 ± 1.1 mm a-1, 1993-2011) imply a considerable acceleration in the rate of barrier migration over the remainder of the 21st century.

  17. Uncorrected refractive error in older British adults: the EPIC-Norfolk Eye Study

    PubMed Central

    Sherwin, Justin C; Khawaja, Anthony P; Broadway, David; Luben, Robert; Hayat, Shabina; Dalzell, Nichola; Wareham, Nicholas J; Khaw, Kay-Tee; Foster, Paul J

    2015-01-01

    Aim To investigate the prevalence of, and demographic associations with, uncorrected refractive error (URE) in an older British population. Methods Data from 4428 participants, aged 48–89 years, who attended an eye examination in the third health check of the European Prospective Investigation into Cancer-Norfolk study and had also undergone an ophthalmic examination were assessed. URE was defined as ≥1 line improvement of visual acuity with pinhole-correction in the better eye in participants with LogMar presenting visual acuity (PVA) <0.3 (PVA <6/12). Refractive error was measured using an autorefractor without cycloplegia. Myopia was defined as spherical equivalent ≤−0.5 dioptre, and hypermetropia ≥0.5 dioptre. Results Adjusted to the 2010 midyear British population, the prevalence of URE in this Norfolk population was 1.9% (95% CI 0.6% to 3.1%). Lower self-rated distance vision was correlated with higher prevalence of URE (ptrend<0.001). In a multivariate logistic regression model adjusting for age, gender, retirement status, educational level and social class, independent significant associations with URE were increasing age (ptrend<0.001) and having hypermetropic or myopic refractive error. Wearing distance spectacles was inversely associated with URE (OR 0.34, 95% CI 0.21 to 0.55, p<0.001). There were 3063 people (69.2%) who wore spectacles/contact lenses for distance vision. Spectacle wear differed according to type of refractive error (p<0.001), and use rose with increasing severity of refractive error (ptrend<0.001). Conclusion Although refractive error is common, the prevalence of URE was found to be low in this population reflecting a low prevalence of PVA<0.3. PMID:22535330

  18. Geologic map and digital database of the Conejo Well 7.5 minute quadrangle, Riverside County, Southern California

    USGS Publications Warehouse

    Powell, Robert E.

    2001-01-01

    This data set maps and describes the geology of the Conejo Well 7.5 minute quadrangle, Riverside County, southern California. The quadrangle, situated in Joshua Tree National Park in the eastern Transverse Ranges physiographic and structural province, encompasses part of the northern Eagle Mountains and part of the south flank of Pinto Basin. It is underlain by a basement terrane comprising Proterozoic metamorphic rocks, Mesozoic plutonic rocks, and Mesozoic and Mesozoic or Cenozoic hypabyssal dikes. The basement terrane is capped by a widespread Tertiary erosion surface preserved in remnants in the Eagle Mountains and buried beneath Cenozoic deposits in Pinto Basin. Locally, Miocene basalt overlies the erosion surface. A sequence of at least three Quaternary pediments is planed into the north piedmont of the Eagle Mountains, each in turn overlain by successively younger residual and alluvial deposits. The Tertiary erosion surface is deformed and broken by north-northwest-trending, high-angle, dip-slip faults in the Eagle Mountains and an east-west trending system of high-angle dip- and left-slip faults. In and adjacent to the Conejo Well quadrangle, faults of the northwest-trending set displace Miocene sedimentary rocks and basalt deposited on the Tertiary erosion surface and Pliocene and (or) Pleistocene deposits that accumulated on the oldest pediment. Faults of this system appear to be overlain by Pleistocene deposits that accumulated on younger pediments. East-west trending faults are younger than and perhaps in part coeval with faults of the northwest-trending set. The Conejo Well database was created using ARCVIEW and ARC/INFO, which are geographical information system (GIS) software products of Envronmental Systems Research Institute (ESRI). The database consists of the following items: (1) a map coverage showing faults and geologic contacts and units, (2) a separate coverage showing dikes, (3) a coverage showing structural data, (4) a point coverage

  19. SeepC: Preliminary Characterization of Atlantic Margin Seep Ecosystems from Norfolk Canyon to New England Seep Sites.

    NASA Astrophysics Data System (ADS)

    Turner, P. J.; Ball, B.; Cole, E.; LaBella, A.; Wagner, J.; Van Dover, C. L.; Skarke, A. D.; Ruppel, C. D.

    2015-12-01

    Since 2013, more than 500 seep sites have been located along the continental margin of the eastern US using acoustic signals of gas plumes in the water column. During a July 2015 R/V Atlantis expedition, scientists used the submersible Alvin to explore seep sites at depths of 300 to 1500 m. Study sites ranged from Norfolk Canyon north to New England Seep 2 and included Baltimore, Veatch, and Shallop Canyon sites, as well as new unnamed sites between Norfolk and Baltimore Canyons. Mussels dominated the seep sites (cf ''Bathymodiolus'' childressi) but only small populations (<10s of individuals) were observed at seep sites associated with Shallop Canyon. B. heckerae, the dominant mussel at the Blake Ridge and Cape Fear seep sites (sites associated with salt diapirs off the Carolinas), appear to be present at only one of the Atlantic Margin seeps. At the Norfolk Canyon site, dead B. heckerae shells were observed and live individuals may be within the explored area. The abundant vesicomyid clam of Blake Ridge and Cape Fear sites was absent at the continental margin seeps. Apart from B. childressi, the most conspicuous megafaunal invertebrate species at the newly explored seeps was the red crab, Chaceon sp. and the rock crab, Cancer sp. These crabs are not seep endemic but they were especially abundant at the seeps and were observed to feed and mate on the seep grounds. Molecular tools will be used to explore the genetic structure of mussel populations from Norfolk to New England seeps, and stable isotope methods will be used to test for differences among sites in the source of carbon used by mussels. Alvin video transects and photo-mosaics will be used to collect data on macrofauna associated with seeps and to test the hypothesis that shallow seeps (300-500m) support more diverse assemblages than deep sites (1000-1500m).

  20. Petrogenesis of the Conejo volcanic suite, southern California: Evidence for mid-ocean ridge continental margin interactions

    NASA Astrophysics Data System (ADS)

    Hurst, Richard W.

    1982-05-01

    The evolution of the southern California Borderland during mid-Miocene time was dependent on the interactions between the North American continent and the converging East Pacific Rise. Evidence from geological and geochemical investigations of the Conejo volcanic suite, whose petrogenesis is linked to these interactions, suggests an intimate relation between the subducting ridge and the volcanic rocks. The whole-rock chemistry of this suite (K2O < 0.4%; 87Sr/86Sr = 0.70248 0.70372, average = 0.70306; TiO2 = 1.2% 1.8%) and restricted range of pyroxene and plagioclase compositions support a model in which active ridge volcanism, fractionation, and mixing of primitive liquids with later differentiates can account for the observed petrologic evolution. The interaction of the ridge with the subduction zone may result in the cessation of subduction, the preferential subduction of the trenchward ridge flank, or localized volcanism in the vicinity of the ridge subduction zone intersection.

  1. The effect of single and concomitant pathogen infections on condition and fecundity of the wild rabbit (Oryctolagus cuniculus).

    PubMed

    Lello, J; Boag, B; Hudson, P J

    2005-12-01

    We assessed the effect of two pathogens (myxoma virus and Eimeria stiedae) and five macroparasites (gastrointestinal helminth species) of the wild rabbit (Oryctolagus cuniculus) upon total host body mass and abdominal fat level. Additionally, we assessed the effects of these organisms on the number of foetuses in adult females during the peak breeding period. Both mass of abdominal fat and total body mass of the rabbit were negatively associated with myxoma virus infection and increasing helminth species richness. Total body mass was also negatively associated with the protozoan parasite E. steidae. No relationship was found between any of the parasites/pathogens and the number of foetuses in adult females, although only relatively small sample sizes were available for this section of the analysis. Increasing host body mass was positively associated with number of foetuses and we propose that mass reduction caused by the pathogen and parasite species could also have the consequence of reducing foetal number. PMID:16051247

  2. Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.

    PubMed

    Lemos de Matos, Ana; McFadden, Grant; Esteves, Pedro J

    2014-01-01

    One of the most severe European rabbit (Oryctolagus cuniculus) pathogens is myxoma virus (MYXV), a rabbit-specific leporipoxvirus that causes the highly lethal disease myxomatosis. Other leporid genera, Sylvilagus and Lepus, encompass species with variable susceptibilities to MYXV, but these do not develop the lethal form of the disease. The protective role of the retinoic acid-inducible gene-I (RIG-I/DDX58) in sensing MYXV in nonpermissive human myeloid cells prompted the study of the RIG-I-like receptor (RLR) family evolution in the three leporid genera. This viral-sensor family also includes the melanoma differentiation-associated factor 5 (MDA5/IFIH1), and the laboratory of genetics and physiology 2 (LGP2/DHX58). Considering specifically the MYXV susceptible host (European rabbit) and one of the virus natural long-term hosts (Sylvilagus bachmani, brush rabbit), the amino acid differences of positively selected sites in RIG-I between the two species were located in the protein region responsible for viral RNA recognition and binding, the repressor domain. Such differences might play a determinant role in how MYXV is sensed. When looking for episodic selection on MDA5 and LGP2 of the eastern cottontail (Sylvilagus floridanus), we also uncovered evidence of selective pressures that might be exerted by a species-specific leporipoxvirus, the Shope fibroma virus. Finally, a putative alternative splicing case was identified in Oryctolagus and Lepus MDA5 isoforms, corresponding to the deletion of one specific exon. This study provided the first insights into the evolution of the leporid RLR gene family that helps illuminate the origins of the species-specific innate responses to pathogens and more specifically to MYXV. PMID:24220721

  3. GRM crustal magnetic anomalies: Separating the Lord Howe Rise and Norfolk Ridge submarine structures

    NASA Technical Reports Server (NTRS)

    Frey, H.

    1985-01-01

    Multiple source bodies often lie within the resolution element of the MAGSAT and POGO data. Small weak sources lying near larger stronger sources will tend to be missed, although they do contribute to the total observed anomaly. Lower elevation magnetic anomaly surveys such as GRM alleviate this problem through the combined effects of significantly greater resolution and stronger signal amplitude. This permits the detection of smaller source bodies, and analysis of their structure and nature. The improvement a GRM will provide is demonstrated in the Lord Howe Rise/Norfolk Ridge area east of Australia, between the Tasman Sea and south Fiji Basin. The submarine features origin have important plate tectonic implications. The Lord Howe Rise (LHR) is a continental fragment broken off from Australia by the opening of the Tasman Sea. It is a wide, shallow structure lying between 160 and 165 deg longitude at 23 to 37 deg S latitude. Seismic refraction data show the LHR crust extending to depths in excess of 20 km.

  4. Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study

    PubMed Central

    Yip, Jennifer L.Y.; Khawaja, Anthony P.; Chan, Michelle P.Y.; Broadway, David C.; Peto, Tunde; Luben, Robert; Hayat, Shabina; Bhaniani, Amit; Wareham, Nick; Foster, Paul J.; Khaw, Kay-Tee

    2015-01-01

    Objectives To investigate the relationship between area deprivation, individual socio-economic status (SES) and age related macular degeneration (AMD). Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by trained nurses, using standardized protocols and lifestyle questionnaires. The English Index of multiple deprivation 2010 (IMD) was derived from participants' postcodes. AMD was identified from standardized grading of fundus photographs. Logistic regression was used to examine associations between IMD, SES and AMD. Results 5344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD. Of 5182 participants with complete data, AMD was identified in 653 participants (12.60%, 95%CI = 11.7–13.5%). Multivariable logistic regression showed that people living in the most affluent 5% of areas had nearly half the odds of AMD compared to those living in comparatively more deprived areas (OR = 0.56, 95% CI = 0.36–0.89, P = 0.02), after adjusting for age, sex, education, social class and smoking. Conclusions The authors found that living in the most affluent areas exerted a protective effect on AMD, independently of education and social class. Further investigation into underlying mechanisms will inform potential interventions to reduce health inequalities relating to AMD. PMID:25687711

  5. A land use and environmental impact analysis of the Norfolk-Portsmouth SMSA

    NASA Technical Reports Server (NTRS)

    Mitchel, W. B.; Berlin, G. L.

    1973-01-01

    The feasibility of using remote sensing techniques for land use and environmental assessment in the Norfolk-Portsmouth area is discussed. Data cover the use of high altitude aircraft and satellite remote sensing data for: (1) identifying various heirarchial levels of land use, (2) monitoring land use changes for repetitive basis, (3) assessing the impact of competing land uses, and (4) identifying areas of potential environmental deterioration. High altitude aircraft photographs (scale 1:120,000) acquired in 1959, 1970, and 1972, plus Earth Resources Technology Satellite (ERTS-1) color composite images acquired in 1972 were used for the land use and environmental assessments. The high altitude aircraft photography, as expected, was successfully used to map Level 1, Level 2, as well as some urban Level 3 land use categories. However, the detail of land use analysis obtainable from the ERTS imagery exceeded the expectations for the U.S. Geological Survey's land use classification scheme. Study results are consistent with the initial investigation which determined Level 1 land use change to be 16.7 square km per year.

  6. Visual acuity, self-reported vision and falls in the EPIC-Norfolk Eye study

    PubMed Central

    Yip, Jennifer L Y; Khawaja, Anthony P; Broadway, David; Luben, Robert; Hayat, Shabina; Dalzell, Nichola; Bhaniani, Amit; Wareham, Nicholas; Khaw, Kay-Tee; Foster, Paul J

    2014-01-01

    Purpose To examine the relationship between visual acuity (VA) and self-reported vision (SRV) in relation to falls in 8317 participants of the European Prospective Investigation into Cancer-Norfolk Eye study. Methods All participants completed a health questionnaire that included a question regarding SRV and questions regarding the number of falls in the past year. Distance VA was measured using a logMAR chart for each eye. Poor SRV was defined as those reporting fair or poor distance vision. The relationship between VA and SRV and self-rated falls was analysed by logistic regression, adjusting for age, sex, physical activity, body mass index, chronic disease, medication use and grip strength. Results Of 8317 participants, 26.7% (95% CI 25.7% to 27.7%) had fallen in the past 12 months. Worse VA and poorer SRV were associated with one or more falls in multivariable analysis (OR for falls=1.31, 95% CI 1.04 to 1.66 and OR=1.32, 95% CI 1.09 to 1.61, respectively). Poorer SRV was significantly associated with falls even after adjusting for VA (OR=1.28, 95% CI 1.05 to 1.57). Conclusions SRV was associated with falls independently of VA and could be used as a simple proxy measure for other aspects of visual function to detect people requiring vision-related falls interventions. PMID:24338086

  7. Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island

    PubMed Central

    Macgregor, Stuart; Bellis, Claire; Lea, Rod A; Cox, Hannah; Dyer, Tom; Blangero, John; Visscher, Peter M; Griffiths, Lyn R

    2010-01-01

    The population of Norfolk Island, located off the eastern coast of Australia, possesses an unusual and fascinating history. Most present-day islanders are related to a small number of the ‘Bounty' mutineer founders. These founders consisted of Caucasian males and Polynesian females and led to an admixed present-day population. By examining a single large pedigree of 5742 individuals, spanning >200 years, we analyzed the influence of admixture and founder effect on various cardiovascular disease (CVD)-related traits. On account of the relative isolation of the population, on average one-third of the genomes of present-day islanders (single large pedigree individuals) is derived from 17 initial founders. The proportion of Polynesian ancestry in the present-day individuals was found to significantly influence total triglycerides, body mass index, systolic blood pressure and diastolic blood pressure. For various cholesterol traits, the influence of ancestry was less marked but overall the direction of effect for all CVD-related traits was consistent with Polynesian ancestry conferring greater CVD risk. Marker-derived homozygosity was computed and agreed with measures of inbreeding derived from pedigree information. Founder effect (inbreeding and marker-derived homozygosity) significantly influenced height. In conclusion, both founder effect and extreme admixture have substantially influenced the genetic architecture of a variety of CVD-related traits in this population. PMID:19584896

  8. Infectious gastroenteritis in Norfolk Island and recovery of viruses from drinking water.

    PubMed Central

    Murphy, A. M.; Grohmann, G. S.; Sexton, M. F.

    1983-01-01

    A high incidence of gastroenteritis in both islanders and tourists has been recorded in recent years on Norfolk Island--a popular tourist resort for Australians and New Zealanders. No bacterial cause has been found. However, electron microscopic examination of 28 faecal specimens revealed viruses associated with gastroenteritis in 21 (75%). No viruses were isolated in cell cultures. Bore water is used for drinking purposes on the island and 32 samples from 15 bores were examined for viruses by electron microscopy and culture as well as for bacterial contamination. Seven polioviruses (all type 1 vaccine strain) and adenoviruses 1 and 5 were isolated in cell cultures. In addition one rotavirus, one adenovirus and two small round viruses were detected by electron microscopy. Six of 21 samples tested showed unacceptably high levels of bacteria for drinking water. The deep ground water has apparently become contaminated with sewage effluent and is almost certainly the main cause of the high level of gastroenteritis on the island. Images Plate 1 PMID:6309956

  9. Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus), but not in species of Cottontail rabbit (Sylvilagus) and Hare (Lepus)

    PubMed Central

    2012-01-01

    Background Recent studies in human have highlighted the importance of the monocyte chemotactic proteins (MCP) in leukocyte trafficking and their effects in inflammatory processes, tumor progression, and HIV-1 infection. In European rabbit (Oryctolagus cuniculus) one of the prime MCP targets, the chemokine receptor CCR5 underwent a unique structural alteration. Until now, no homologue of MCP-2/CCL8a, MCP-3/CCL7 or MCP-4/CCL13 genes have been reported for this species. This is interesting, because at least the first two genes are expressed in most, if not all, mammals studied, and appear to be implicated in a variety of important chemokine ligand-receptor interactions. By assessing the Rabbit Whole Genome Sequence (WGS) data we have searched for orthologs of the mammalian genes of the MCP-Eotaxin cluster. Results We have localized the orthologs of these chemokine genes in the genome of European rabbit and compared them to those of leporid genera which do (i.e. Oryctolagus and Bunolagus) or do not share the CCR5 alteration with European rabbit (i.e. Lepus and Sylvilagus). Of the Rabbit orthologs of the CCL8, CCL7, and CCL13 genes only the last two were potentially functional, although showing some structural anomalies at the protein level. The ortholog of MCP-2/CCL8 appeared to be pseudogenized by deleterious nucleotide substitutions affecting exon1 and exon2. By analyzing both genomic and cDNA products, these studies were extended to wild specimens of four genera of the Leporidae family: Oryctolagus, Bunolagus, Lepus, and Sylvilagus. It appeared that the anomalies of the MCP-3/CCL7 and MCP-4/CCL13 proteins are shared among the different species of leporids. In contrast, whereas MCP-2/CCL8 was pseudogenized in every studied specimen of the Oryctolagus - Bunolagus lineage, this gene was intact in species of the Lepus - Sylvilagus lineage, and was, at least in Lepus, correctly transcribed. Conclusion The biological function of a gene was often revealed in situations of

  10. Plant uptake and soil retention of phthalic acid applied to Norfolk sandy loam

    SciTech Connect

    Dorney, J.R.; Weber, J.B.; Overcash, M.R.; Strek, H.J.

    1985-01-01

    Plant uptake and soil retention of /sup 14/C carboxyl-labeled phthalic acid were studied at application rates of 0.6, 6.0, 60.0, and 600.0 ppm (soil dry weight) to Norfolk sandy loam (Typic Paleudult, fine loamy, kaolinitic, thermic). Height and dry weight of corn (Zea mays L. Pioneer 3368A) (21 day), tall fescue (Festuca arundinacea Schreb. Kentucky 31) (45 day) immature soybean (Glycine max (L.) Merr. Altoona) (21 day) plant, mature soybean plant, and mature wheat (Triticum aestivum L. Butte) straw were not affected by phthalic acid applied to soil. In addition, soybean seed and wheat seed dry weight were unaffected. Immature wheat (40 day) height decreased at the 600 ppm rate. Plant uptake of phthalic acid ranged from 0 to 23 ppm and was significantly above background for all plants and plant materials except soybean pods. Fescue and immature plants exhibited the highest concentration of phthalic acid while mature wheat plants and wheat seeds exhibited the least. Most of the phthalic acid volatilized or was decomposed from the soil by the end of the study; an average of only 5.7% of the originally applied chemical was recovered in both soil or plants. An average of 0.02% of the originally applied phthalic acid leached out of the treated zone. Considering the low toxicity of phthalic acid and its relatively rapid disappearance from soil, it is unlikely to become a health hazard from contaminated plants. However, plant uptake of other toxic organics could potentially become a hazard on soils treated with sludge containing significant quantities of these substances.

  11. Management and valuation of an environmentally sensitive area: Norfolk Broadland, England, case study

    NASA Astrophysics Data System (ADS)

    Turner, R. Kerry; Brooke, Jan

    1988-03-01

    Wetlands, like any other environmentally sensitive resource, require very careful evaluation. While it is accepted that all wetlands may be equally valuable in terms of maintaining global life-support systems, individual areas may be ranked according to their uniqueness or the irreplaceability of the resource should the wetland be developed. The various techniques available for evaluating the wetland resource in the development versus conservation conflict situation are critically assessed. Indirect appraisal via the opportunity cost method can generate valuable data which have contributed to the mitigation of such conflict situations. The Broadland, in Norfolk, England, recently designated an environmentally sensitive area (ESA), provides a case study example of wetland management. The search for an “acceptable” flood alleviation strategy for the ESA is examined in detail. The economic and environmental asset structure of the study area is examined at two levels. A basic “screening” system is applied to each of the identified flood protection planning units to enable the rank ordering of the units. A more detailed appraisal is then made of the value of selected units so that the cost-effectiveness of any planned expenditure on flood protection works can be assessed. Specific management issues and their likely effect on the environment, in terms of land use for example, are also addressed. The 1986 Agriculture Act marks a potential watershed in British conservation policy. The ESA policy encompasses a dual management strategy that attempts to stimulate compatible agricultural and conservation practices and activities. Other countries that still retain significant unspoiled wetland resources may find that preemptive regulatory government intervention in favor of conservation would help to avoid the worst aspects of the British experience.

  12. Principal Component and Linkage Analysis of Cardiovascular Risk Traits in the Norfolk Isolate

    PubMed Central

    Cox, Hannah C.; Bellis, Claire; Lea, Rod A.; Quinlan, Sharon; Hughes, Roger; Dyer, Thomas; Charlesworth, Jac; Blangero, John; Griffiths, Lyn R.

    2009-01-01

    Objective(s) An individual's risk of developing cardiovascular disease (CVD) is influenced by genetic factors. This study focussed on mapping genetic loci for CVD-risk traits in a unique population isolate derived from Norfolk Island. Methods This investigation focussed on 377 individuals descended from the population founders. Principal component analysis was used to extract orthogonal components from 11 cardiovascular risk traits. Multipoint variance component methods were used to assess genome-wide linkage using SOLAR to the derived factors. A total of 285 of the 377 related individuals were informative for linkage analysis. Results A total of 4 principal components accounting for 83% of the total variance were derived. Principal component 1 was loaded with body size indicators; principal component 2 with body size, cholesterol and triglyceride levels; principal component 3 with the blood pressures; and principal component 4 with LDL-cholesterol and total cholesterol levels. Suggestive evidence of linkage for principal component 2 (h2 = 0.35) was observed on chromosome 5q35 (LOD = 1.85; p = 0.0008). While peak regions on chromosome 10p11.2 (LOD = 1.27; p = 0.005) and 12q13 (LOD = 1.63; p = 0.003) were observed to segregate with principal components 1 (h2 = 0.33) and 4 (h2 = 0.42), respectively. Conclusion(s): This study investigated a number of CVD risk traits in a unique isolated population. Findings support the clustering of CVD risk traits and provide interesting evidence of a region on chromosome 5q35 segregating with weight, waist circumference, HDL-c and total triglyceride levels. PMID:19339786

  13. Long-term mortality of hospitalized pneumonia in the EPIC-Norfolk cohort.

    PubMed

    Myint, P K; Hawkins, K R; Clark, A B; Luben, R N; Wareham, N J; Khaw, K-T; Wilson, A M

    2016-03-01

    Little is known about cause-specific long-term mortality beyond 30 days in pneumonia. We aimed to compare the mortality of patients with hospitalized pneumonia compared to age- and sex-matched controls beyond 30 days. Participants were drawn from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study. Hospitalized pneumonia cases were identified from record linkage (ICD-10: J12-J18). For this study we excluded people with hospitalized pneumonia who died within 30 days. Each case identified was matched to four controls and followed up until the end June 2012 (total 15 074 person-years, mean 6·1 years, range 0·08-15·2 years). Cox regression models were constructed to examine the all-cause, respiratory and cardiovascular mortality using date of pneumonia onset as baseline with binary pneumonia status as exposure. A total of 2465 men and women (503 cases, 1962 controls) [mean age (s.d.) 64·5 (8·3) years] were included in the study. Between a 30-day to 1-year period, hazard ratios (HRs) of all-cause and cardiovascular mortality were 7·3 [95% confidence interval (CI) 5·4-9·9] and 5·9 (95% CI 3·5-9·7), respectively (with very few respiratory deaths within the same period) in cases compared to controls after adjusting for age, sex, asthma, smoking status, pack years, systolic and diastolic blood pressure, diabetes, physical activity, waist-to-hip ratio, prevalent cardiovascular and respiratory diseases. All outcomes assessed also showed increased risk of death in cases compared to controls after 1 year; respiratory cause of death being the most significant during that period (HR 16·4, 95% CI 8·9-30·1). Hospitalized pneumonia was associated with increased all-cause and specific-cause mortality beyond 30 days. PMID:26300532

  14. Habitat use for warren building by European rabbits ( Oryctolagus cuniculus) in relation to landscape structure in a sand dune system

    NASA Astrophysics Data System (ADS)

    Dellafiore, Claudia M.; Gallego Fernández, Juan B.; Vallés, Sara Muñoz

    2008-05-01

    Several conservation efforts are being made to recover European rabbit populations ( Oryctolagus cuniculus) on the Iberian Peninsula. Some of them focus on burrow management; others involve building different types of warren. A few studies have examined site selection for warren building, and these studies have considered only warren placement within sites and not the broader area surrounding these locations. The objective of this study was to evaluate how landscape pattern determines habitat selection by rabbits for warren building at different spatial scales. Landscape, home range scale, and microhabitat were the spatial scales used in this study. Warrens were not uniformly distributed over the study area but, rather were concentrated in areas with a high abundance and cover of Retama monosperma and high vegetation cover. Rabbits preferred digging warrens in areas with low fragmentation and where patches are few, large, and contiguous. Based on our results, we suggest that a study of landscape structure should be carried out before design habitat management, recovery or translocation programs. Such studies will need to take into account the physiognomy and size, shape, and continuity of patches in fragmented landscapes. Rabbit conservation programs must address areas that provide not only the maximum potential rate of intake, but also good soil and vegetation cover conditions for warren building and suitable surrounding areas.

  15. Cod Liver Oil Supplement Consumption and Health: Cross-sectional Results from the EPIC-Norfolk Cohort Study

    PubMed Central

    Lentjes, Marleen A.H.; Welch, Ailsa A.; Mulligan, Angela A.; Luben, Robert N.; Wareham, Nicholas J.; Khaw, Kay-Tee

    2014-01-01

    Supplement users (SU) make healthy lifestyle choices; on the other hand, SU report more medical conditions. We hypothesised that cod liver oil (CLO) consumers are similar to non-supplement users, since CLO use might originate from historical motives, i.e., rickets prevention, and not health consciousness. CLO consumers were studied in order to identify possible confounders, such as confounding by indication. The European Prospective Investigation into Cancer (EPIC) investigates causes of chronic disease. The participants were 25,639 men and women, aged 40–79 years, recruited from general practices in Norfolk, East-Anglia (UK). Participants completed questionnaires and a health examination between 1993 and 1998. Supplement use was measured using 7-day diet diaries. CLO was the most common supplement used, more prevalent among women and associated with not smoking, higher physical activity level and more favourable eating habits. SU had a higher occurrence of benign growths and bone-related diseases, but CLO was negatively associated with cardiovascular-related conditions. Although the results of SU characteristics in EPIC-Norfolk are comparable with studies worldwide, the CLO group is different from SU in general. Confounding by indication takes place and will need to be taken into account when analysing prospective associations of CLO use with fracture risk and cardiovascular diseases. PMID:25325252

  16. Cod liver oil supplement consumption and health: cross-sectional results from the EPIC-Norfolk cohort study.

    PubMed

    Lentjes, Marleen A H; Welch, Ailsa A; Mulligan, Angela A; Luben, Robert N; Wareham, Nicholas J; Khaw, Kay-Tee

    2014-10-01

    Supplement users (SU) make healthy lifestyle choices; on the other hand, SU report more medical conditions. We hypothesised that cod liver oil (CLO) consumers are similar to non-supplement users, since CLO use might originate from historical motives, i.e., rickets prevention, and not health consciousness. CLO consumers were studied in order to identify possible confounders, such as confounding by indication. The European Prospective Investigation into Cancer (EPIC) investigates causes of chronic disease. The participants were 25,639 men and women, aged 40-79 years, recruited from general practices in Norfolk, East-Anglia (UK). Participants completed questionnaires and a health examination between 1993 and 1998. Supplement use was measured using 7-day diet diaries. CLO was the most common supplement used, more prevalent among women and associated with not smoking, higher physical activity level and more favourable eating habits. SU had a higher occurrence of benign growths and bone-related diseases, but CLO was negatively associated with cardiovascular-related conditions. Although the results of SU characteristics in EPIC-Norfolk are comparable with studies worldwide, the CLO group is different from SU in general. Confounding by indication takes place and will need to be taken into account when analysing prospective associations of CLO use with fracture risk and cardiovascular diseases. PMID:25325252

  17. The Content Validation and Resource Development For a Course in Materials and Processes of Industry Through the Use of NASA Experts at Norfolk State College. Final Report.

    ERIC Educational Resources Information Center

    Jacobs, James A.

    In an effort to develop a course in materials and processes of industry at Norfolk State College using Barton Herrscher's model of systematic instruction, a group of 12 NASA-Langley Research Center's (NASA-LRC) research engineers and technicians were recruited. The group acted as consultants in validating the content of the course and aided in…

  18. Selected Papers & Abstracts from the Annual International Conference of the Association for Experiential Education (32nd, Norfolk, Virginia, November 4-7, 2004)

    ERIC Educational Resources Information Center

    Roberts, Nina S., Ed.; Galloway, Shayne, Ed.

    2005-01-01

    In an effort to persist with providing members--and interested others--with the content of workshops from the 32nd Annual Conference held in Norfolk, the Association for Experiential Education (AEE) has decided to develop a hybrid publication that has materialized in two parts. Part I includes 11 papers: (1) Adventure Coaching (Doug Gray); (2)…

  19. Anthropogenic contribution to the geological and geomorphological record: A case study from Great Yarmouth, Norfolk, UK

    NASA Astrophysics Data System (ADS)

    Jordan, Hannah; Hamilton, Ken; Lawley, Russell; Price, Simon James

    2016-01-01

    Reconstruction of artificial or anthropogenic topographies, sediment thicknesses and volumes provides a mechanism for quantifying anthropogenic changes to sedimentary systems in the context of the proposed Anthropocene epoch. We present a methodology for determining the volumetric contribution of anthropogenic deposits to the geological and geomorphological record and apply it to the Great Yarmouth area of Norfolk, UK. 115 boreholes, drilled to a maximum depth of 6 m below ground level, were used to determine the thickness and distribution of seven geo-archaeological units comprising natural and anthropogenic deposits in the central Great Yarmouth area. This was supplemented by additional depth information derived from 467 existing ground investigation boreholes and published 1:50 000 scale geological maps. The top and base of each geo-archaeological unit were modelled from elevations recorded in the borehole data. Grids were produced using a natural neighbour analysis with a 25 m cell size using MapInfo 8.0 Vertical Mapper 3.1 to produce palaeotopographical surfaces. Maximum, minimum and average elevations for each geo-archaeological unit generally increase with decreasing age with the exception of the Early-Medieval palaeotopographical surface which locally occurs at higher elevations than that of the younger Late-Medieval unit. The total sediment volume for the combined Modern, Post-Medieval, Late-Medieval and Early-Medieval geo-archaeological units is 10.91 × 105 m3. The total sediment volume for the Aeolian, River Terrace and Marine geo-archaeological units combined is 65.58 × 105 m3. Anthropogenic sedimentation rates were calculated to increase from ~ 590 m3/yr during the Early-Medieval period, ~ 1500 m3/yr during the Post-Medieval period and ~ 2300 m3/yr during the Modern period. It is estimated that the combined anthropogenic geo-archaeological units contribute approximately 15% of the total volume of sediments that would have been traditionally

  20. Composition, distribution and regional affinities of the deepwater ichthyofauna of the Lord Howe Rise and Norfolk Ridge, south-west Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Zintzen, Vincent; Roberts, Clive D.; Clark, Malcolm R.; Williams, Alan; Althaus, Franziska; Last, Peter R.

    2011-04-01

    Fishes were collected from seamounts and insular slopes of the northern Tasman and southern Coral Seas in the environs of the Reinga Ridge, Norfolk Ridge and Lord Howe Rise, at depths ranging from 49 to 1927 m. A total of 348 demersal fish species in 99 families, which were collected from 135 samples taken with a variety of sampling gear, greatly improved taxonomic knowledge of this poorly known area. Twenty five percent of the fish sampled are considered to be potentially new species. Relatively high levels of regional endemicity and diversity are attributed to geological history, and the complexity of contemporary climatology, hydrography and habitat diversity of the region. Fish assemblages were highly structured by depth, but across regions, deep-water fish faunas showed stronger taxonomic affinities than shallower faunas. Although less pronounced, spatial differences pointed towards distinct faunas between the southern and northern parts of the area. The distribution patterns and affinities to regions adjacent to the survey area indicate that (1) the fish fauna on the Lord Howe Rise near Lord Howe Island and further north is distinct from the rest of the survey regions, and exhibits eastern Australian and northern (Coral Sea) affinities, (2) the Northern Norfolk Ridge fauna is distinct from the other regions and has strong affinities with New Caledonia, (3) fishes on the Southern Norfolk Ridge, Western Norfolk Ridge and Lord Howe Plateau have more shared species compared to the other regions indicating a high level of connectedness and affinities with New Zealand fauna, and (4) some species have a wide distribution along the Norfolk Ridge providing a possible deepwater pathway between New Caledonia and New Zealand. Survey data is also useful for assessing the regions' conservation values by identifying rare or unusual components of the fauna, those with very limited distributions, those with low productivity that may be vulnerable to human disturbance (fishing

  1. High-throughput SNP discovery in the rabbit (Oryctolagus cuniculus) genome by next-generation semiconductor-based sequencing.

    PubMed

    Bertolini, F; Schiavo, G; Scotti, E; Ribani, A; Martelli, P L; Casadio, R; Fontanesi, L

    2014-04-01

    The European rabbit (Oryctolagus cuniculus) is a domesticated species with one of the broadest ranges of economic and scientific applications and fields of investigation. Rabbit genome information and assembly are available (oryCun2.0), but so far few studies have investigated its variability, and massive discovery of polymorphisms has not been published yet for this species. Here, we sequenced two reduced representation libraries (RRLs) to identify single nucleotide polymorphisms (SNPs) in the rabbit genome. Genomic DNA of 10 rabbits belonging to different breeds was pooled and digested with two restriction enzymes (HaeIII and RsaI) to create two RRLs which were sequenced using the Ion Torrent Personal Genome Machine. The two RRLs produced 2 917 879 and 4 046 871 reads, for a total of 280.51 Mb (248.49 Mb with quality >20) and 417.28 Mb (360.89 Mb with quality >20) respectively of sequenced DNA. About 90% and 91% respectively of the obtained reads were mapped on the rabbit genome, covering a total of 15.82% of the oryCun2.0 genome version. The mapping and ad hoc filtering procedures allowed to reliably call 62 491 SNPs. SNPs in a few genomic regions were validated by Sanger sequencing. The Variant Effect Predictor Web tool was used to map SNPs on the current version of the rabbit genome. The obtained results will be useful for many applied and basic research programs for this species and will contribute to the development of cost-effective solutions for high-throughput SNP genotyping in the rabbit. PMID:24444082

  2. Combined effect of health behaviours and risk of first ever stroke in 20 040 men and women over 11 years’ follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study

    PubMed Central

    Luben, Robert N; Wareham, Nicholas J; Bingham, Sheila A; Khaw, Kay-Tee

    2009-01-01

    Objective To quantify the potential combined impact of four health behaviours on incidence of stroke in men and women living in the general community. Design Population based prospective study (EPIC-Norfolk). Setting Norfolk, United Kingdom. Participants 20 040 men and women aged 40-79 with no known stroke or myocardial infarction at baseline survey in 1993-7, living in the general community, and followed up to 2007. Main outcome measure Participants scored one point for each health behaviour: current non-smoking, physically not inactive, moderate alcohol intake (1-14 units a week), and plasma concentration of vitamin C ≥50 µmol/l, indicating fruit and vegetable intake of at least five servings a day, for a total score ranging from 0 to 4. Results There were 599 incident strokes over 229 993 person years of follow-up; the average follow-up was 11.5 years. After adjustment for age, sex, body mass index (BMI), systolic blood pressure, cholesterol concentration, history of diabetes and aspirin use, and social class, compared with people with the four health behaviours the relative risks for stroke for men and women were 1.15 (95% confidence interval 0.89 to 1.49) for three health behaviours, 1.58 (1.22 to 2.05) for two, 2.18 (1.63 to 2.92) for one, and 2.31 (1.33 to 4.02) for none (P<0.001 for trend). The relations were consistent in subgroups stratified by sex, age, body mass index, and social class, and after exclusion of deaths within two years. Conclusion Four health behaviours combined predict more than a twofold difference in incidence of stroke in men and women. PMID:19228771

  3. Pollution prevention opportunity assessment United States Naval Base Norfolk Naval Air Station. Project report, 20 June-30 September 1994

    SciTech Connect

    Bowman, D.; DeWaters, J.; Smith, J.; Snow, S.; Thomas, R.

    1995-08-01

    The approach for conducting a Pollution Prevention Opportunity Assessment (PPOA) at the Norfolk NAS is described along with background information about the site. Section 2 provides background information related to cooling tower operations and water treatment processes. Section 3 describes the current cooling tower activities and operations that were observed during the NAS site visit. Possible alternative practices for minimizing these wastes are discussed in Section 4. Recommendations on potential follow-up activities are also included in Section 4. Appendices include PPOA worksheets (Appendix A), National Pollutant Discharge Elimination Systems (NPDES) discharge limits (Appendix B), discharge data (Appendix C), material safety data sheets (MSDS) (Appendix D), the Hampton Roads Sanitation District Cooling Tower Waste Discharge Policy with Industrial Wastewater Pollutant Limitations and Discharge Requirements (Appendix E), and the MSDS for DIAS-Aid Tower Treatment XP-300 (Appendix F).

  4. A new species of lithistid sponge hiding within the Isabella mirabilis species complex (Porifera: Demospongiae: Tetractinellida) from seamounts of the Norfolk Ridge.

    PubMed

    Ekins, Merrick; Erpenbeck, Dirk; Wörheide, Gert; Hooper, John N A

    2016-01-01

    A population level study of the lithistid ('rock') sponge, Isabella mirabilis, revealed a new species, Isabella tanoa sp. nov., living on five seamounts on the Norfolk Ridge, SW Pacific, and representing the third species to be discovered since the genus was first described in 2005. Comparisons between the three species showed significant differences in morphological characters that corresponded to differences in their respective CO1 barcoding sequences. Conversely, three of the four genotypes of Isabella mirabilis remain unresolved using morphological markers. PMID:27395728

  5. Geology and mineral resources of the Florence, Beaufort, Rocky Mount, and Norfolk 1/sup 0/ x 2/sup 0/ NTMS quadrangles. National Uranium Resource Evaluation program

    SciTech Connect

    Harris, W.B.

    1982-08-01

    This document provides geologic and mineral resources data for previously-issued Savannah River Laboratory hydrogeochemical and stream sediment reports of the Beaufort, Florence, Norfolk, and Rocky Mount 1/sup 0/ x 2/sup 0/ National Topographic Map Series quadrangles in the southeastern United States. This report is issued in draft form, without detailed technical and copy editing. This was done to make the report available to the public before the end of the National Uranium Resource Evaluation program.

  6. A case of antibacterial-responsive mucocutaneous disease in a seven-year-old dwarf lop rabbit (Oryctolagus cuniculus) resembling mucocutaneous pyoderma of dogs.

    PubMed

    Benato, L; Stoeckli, M R; Smith, S H; Dickson, S; Thoday, K L; Meredith, A

    2013-04-01

    A seven-year-old, ovariohysterectomised female dwarf lop rabbit (Oryctolagus cuniculus) was referred with severe swelling and erythema of the mucocutaneous junctions of the lips, nares and vulva. Bilateral, severe periocular dermatitis was also present. Heavy pure growths of a member of the Staphylococcus intermedius group were cultured from nasal and aural swabs and skin biopsies. Other possible differential diagnoses were eliminated by standard tests. The clinical features and histopathological characteristics of the biopsies were most consistent with mucocutaneous pyoderma, a dermatosis previously reported in dogs but not in rabbits. Treatment of the bacterial infection with oral marbofloxacin and topical ofloxacin eye drops together with supportive therapy resulted in resolution of the lesions. To the authors' knowledge, this is the first report of mucocutaneous bacterial pyoderma, similar to mucocutaneous pyoderma of dogs, in a rabbit. PMID:23346925

  7. CARETS: A prototype regional environmental information system. Volume 2, parts A and B: Norfolk and environs; a land use perspective

    NASA Technical Reports Server (NTRS)

    Alexander, R. H. (Principal Investigator); Buzzanell, P. J.; Fitzpatrick, K. A.; Lins, H. F., Jr.; Mcginty, H. K., III

    1975-01-01

    The author has identified the following significant results. The Norfolk-Portsmouth metropolitan statistical area in southeastern Virginia was the site of intensive testing of a number of land resources assessment methods. Land use and land cover data at three levels of detail were derived by manual image interpretation from both aircraft and satellite sources and used to characterize the 1,766 sq km (682 sq mi) area from the perspective of its various resource-related activities and problems. Measurements at level 1 from 1:100, 000 scale maps revealed 42 percent of the test area (excluding bays and estuaries) to be forest, 28 percent agriculture, 23 percent urban and built-up, 4 percent nonforested wetlands, and 2 percent water. At the same scale and level of detail, 10 percent of the area underwent change from one land use category to another in the period 1959-70, 62 percent of which involved the relatively irreversible change from forest or agriculture to urban uses.

  8. Dietary intake measurement using 7 d diet diaries in British men and women in the European Prospective Investigation into Cancer-Norfolk study: a focus on methodological issues.

    PubMed

    Lentjes, Marleen A H; McTaggart, Alison; Mulligan, Angela A; Powell, Natasha A; Parry-Smith, David; Luben, Robert N; Bhaniani, Amit; Welch, Ailsa A; Khaw, Kay-Tee

    2014-02-01

    The aim of the present study was to describe the energy, nutrient and crude v. disaggregated food intake measured using 7 d diet diaries (7dDD) for the full baseline Norfolk cohort recruited for the European Prospective Investigation into Cancer (EPIC-Norfolk) study, with emphasis on methodological issues. The first data collection took place between 1993 and 1998 in Norfolk, East Anglia (UK). Of the 30,445 men and women, aged 40-79 years, registered with a general practitioner invited to participate in the study, 25,639 came for a health examination and were asked to complete a 7dDD. Data from diaries with data recorded for at least 1 d were obtained for 99% members of the cohort; 10,354 (89·8%) of the men and 12,779 (91·5%) of the women completed the diet diaries for all 7 d. Mean energy intake (EI) was 9·44 (SD 2·22) MJ/d and 7·15 (SD 1·66) MJ/d, respectively. EI remained approximately stable across the days, but there was apparent under-reporting among the participants, especially among those with BMI >25 kg/m². Micronutrient density was higher among women than among men. In conclusion, under-reporting is an issue, but not more so than that found in national surveys. How foods were grouped (crude or disaggregated) made a difference to the estimates obtained, and comparison of intakes showed wide limits of agreement. The choice of variables influences estimates obtained from the food group data; while this may not alter the ranking of individuals within studies, this issue may be relevant when comparing absolute food intakes between studies. PMID:24041116

  9. Self-Rated Health and Cardiovascular Disease Incidence: Results from a Longitudinal Population-Based Cohort in Norfolk, UK

    PubMed Central

    van der Linde, Rianne M.; Mavaddat, Nahal; Luben, Robert; Brayne, Carol; Simmons, Rebecca K.; Khaw, Kay Tee; Kinmonth, Ann Louise

    2013-01-01

    Introduction Self-rated health (SRH) predicts chronic disease morbidity including cardiovascular disease (CVD). In a population-based cohort, we examined the association between SRH and incident CVD and whether this association was independent of socio-demographic, clinical and behavioural participant characteristics. Methods Population-based prospective cohort study (European Prospective Investigation of Cancer-Norfolk). 20,941 men and women aged 39–74 years without prevalent CVD attended a baseline health examination (1993–1998) and were followed for CVD events/death until March 2007 (mean 11 years). We used a Cox proportional hazards model to quantify the association between baseline SRH (reported on a four point scale – excellent, good, fair, poor) and risk of developing CVD at follow-up after adjusting for socio-demographic, clinical and behavioural risk factors. Results Baseline SRH was reported as excellent by 17.8% participants, good by 65.1%, fair by 16.0% and poor by 1.2%. During 225,508 person-years of follow-up, there were 55 (21.2%) CVD events in the poor SRH group and 259 (7.0%) in the excellent SRH group (HR 3.7, 95% CI 2.8–4.9). The HR remained significant after adjustment for behavioural risk factors (HR 2.6, 95% CI 1.9–3.5) and after adjustment for all socio-demographic, clinical and behavioural risk factors (HR 3.3, 95% CI 2.4–4.4). Associations were strong for both fatal and non-fatal events and remained strong over time. Conclusions SRH is a strong predictor of incident fatal and non-fatal CVD events in this healthy, middle-aged population. Some of the association is explained by lifestyle behaviours, but SRH remains a strong predictor after adjustment for socio-demographic, clinical and behavioural risk factors and after a decade of follow-up. This easily accessible patient-centred measure of health status may be a useful indicator of individual and population health for those working in primary care and public health. PMID

  10. Selected water-quality characteristics and flow of ground water in the San Luis basin, including the Conejos River subbasin, Colorado and New Mexico

    USGS Publications Warehouse

    Williams, R.S., Jr.; Hammond, S.E.

    1989-01-01

    Chemical analyses of water from 99 wells and 19 springs in the San Luis basin in Colorado and New Mexico were evaluated to determine selected water quality characteristics as an aid in understanding the flow of groundwater in the basin. The evaluation shows that the distribution of chemical water types in the basin is consistent with chemical changes to be expected along flow paths in rocks typical of those in the basin. The San Luis basin area is underlain by a surficial (< 100-ft-thick) unconfined aquifer and, in turn, by a confining bed and a deeper confined aquifer. Previous studies have indicated that the groundwater system is recharged around the edges of the basin and that groundwater then moves toward discharge areas in the topographically closed part of the basin and along principal streams. The evaluation of water quality data showed that groundwater at the perimeter of the San Luis basin is primarily a calcium bicarbonate type, which is typical in recharge areas. Groundwater near the center of the basin is primarily a sodium bicarbonate type, which is typical of groundwater in downgradient areas. The change in principal cation from calcium to sodium indicates chemical evolution of the water along the groundwater flow path and supports previously developed concepts of groundwater movement in the basin. The exchange of calcium for sodium along the flow path also is assumed to occur in the Conejos River subbasin. Upgradient wells yield calcium bicarbonate type water, whereas downgradient wells yield sodium bicarbonate type water. However, an exception to this relation is found at McIntire Spring, which yields calcium bicarbonate type water from a downgradient location. The source of water discharging from the spring may be the confined aquifer, with hydraulic connection along the Manassa fault. The concentration of dissolved solids in water from both the unconfined and confined aquifers increases downgradient. The increase is dramatic in the closed basin

  11. Preliminary Geologic Map of the North-Central Part of the Alamosa 30' x 60' Quadrangle, Alamosa, Conejos and Costilla Counties, Colorado

    USGS Publications Warehouse

    Machette, Michael N.; Thompson, Ren A.; Brandt, Theodore R.

    2008-01-01

    This geologic map presents new polygon (geologic map unit contacts) and line (terrace and lacustrine spit/barrier bar) vector data for a map comprised of four 7.5' quadrangles in the north-central part of the Alamosa, Colorado, 30' x 60' quadrangle. The quadrangles include Baldy, Blanca, Blanca SE, and Lasauses. The map database, compiled at 1:50,000 scale from new 1:24,000-scale mapping, provides geologic coverage of an area of current hydrogeologic, tectonic, and stratigraphic interest. The mapped area is located primarily in Costilla County, but contains portions of Alamosa and Conejos Counties, and includes the town of Blanca in its northeastern part. The map area is mainly underlain by surficial geologic materials (fluvial and lacustrine deposits, and eolian sand), but Tertiary volcanic and volcaniclastic rocks crop out in the San Luis Hills, which are in the central and southern parts of the mapped area. The surficial geology of this area has never been mapped at any scale greater than 1:250,000 (broad reconnaissance), so this new map provides important data for ground-water assessments, engineering geology, and the Quaternary geologic history of the San Luis Basin. Newly discovered shoreline deposits are of particular interest (sands and gravels) that are associated with the high-water stand of Lake Alamosa, a Pliocene to middle Pleistocene lake that occupied the San Luis basin prior to its overflow and cutting of a river gorge through the San Luis Hills. After the lake drained, the Rio Grande system included Colorado drainages for the first time since the Miocene (>5.3 Ma). In addition, Servilleta Basalt, which forms the Basaltic Hills on the east margin of the map area, is dated at 3.79+or-0.17 Ma, consistent with its general age range of 3.67-4.84 Ma. This map provides new geologic information for better understanding ground-water flow paths in and adjacent to the Rio Grande system. The map abuts U.S. Geological Survey Open File Report 2005-1392 (a map of

  12. Primary and secondary experimental infestation of rabbits (Oryctolagus cuniculus) with Sarcoptes scabiei from a wild rabbit: factors determining resistance to reinfestation.

    PubMed

    Casais, Rosa; Dalton, Kevin P; Millán, Javier; Balseiro, Ana; Oleaga, Alvaro; Solano, Paloma; Goyache, Félix; Prieto, José Miguel; Parra, Francisco

    2014-06-16

    Studies of sarcoptic mange and immunity are hampered by lack of mite sources and natural infestation models. We have investigated the clinical and pathological signs, specific IgG response and acquired immunity in naïve New Zealand White rabbits (Oryctolagus cuniculus) experimentally infested with Sarcoptes scabiei originally isolated from a clinically affected free-living European wild rabbit. Twenty rabbits were infested using two methods, direct contact for a 24 h period with a seeder rabbit simulating the natural process of infestation and application of a dressing holding approximately 1800 live mites on each hind limb (foot area) for a 24h period. Eight weeks post infestation, rabbits were treated with ivermectin and infestation cleared. Eight weeks later seventeen previously infested and four uninfested naïve controls were then re-exposed to the same S. scabiei variety using the same methods and followed for another 8 weeks. The progress of the disease was markedly more virulent in the animals infested by contact, indicating that the effective dose of mites managing to thrive and infest each rabbit by this method was higher. Nevertheless, infestation by contact resulted in partial protection to reexposure, rabbits developed high non-protective antibody titres upon reinfestation and presented severe clinical signs. However, rabbits reinfested by dressing developed lower IgG titres, and presented high levels of resistance to reinfestation, which might be due to induction of a strong local cellular response in the inoculation point that killed the mites and resulted in a lower mite effective dose, with subsequent reduced lesion development. Statistical analysis showed that sex, method of infestation and previous exposure are key factors determining the ability of rabbits to develop immunity to this disease. The rabbit-mange model developed will allow the further study of immunity and resistance to this neglected pathogen using a natural host system. PMID

  13. Assessing Animal Welfare Impacts in the Management of European Rabbits (Oryctolagus cuniculus), European Moles (Talpa europaea) and Carrion Crows (Corvus corone).

    PubMed

    Baker, Sandra E; Sharp, Trudy M; Macdonald, David W

    2016-01-01

    Human-wildlife conflict is a global issue. Attempts to manage this conflict impact upon wild animal welfare, an issue receiving little attention until relatively recently. Where human activities harm animal welfare these effects should be minimised where possible. However, little is known about the welfare impacts of different wildlife management interventions, and opinions on impacts vary widely. Welfare impacts therefore need to be assessed objectively. Our objectives were to: 1) establish whether an existing welfare assessment model could differentiate and rank the impacts of different wildlife management interventions (for decision-making purposes); 2) identify and evaluate any additional benefits of making formal welfare assessments; and 3) illustrate issues raised by application of the model. We applied the welfare assessment model to interventions commonly used with rabbits (Oryctolagus cuniculus), moles (Talpa europaea) and crows (Corvus corone) in the UK. The model ranked interventions for rabbits (least impact first: fencing, head shot, chest shot) and crows (shooting, scaring, live trapping with cervical dislocation). For moles, managing molehills and tunnels scored least impact. Both spring trapping, and live trapping followed by translocation, scored greater impacts, but these could not be compared directly as they scored on different axes of the model. Some rankings appeared counter-intuitive, highlighting the need for objective formal welfare assessments. As well as ranking the humaneness of interventions, the model highlighted future research needs and how Standard Operating Procedures might be improved. The model is a milestone in assessing wildlife management welfare impacts, but our research revealed some limitations of the model and we discuss likely challenges in resolving these. In future, the model might be developed to improve its utility, e.g. by refining the time-scales. It might also be used to reach consensus among stakeholders about

  14. Intake, selection, digesta retention, digestion and gut fill of two coprophageous species, rabbits (Oryctolagus cuniculus) and guinea pigs (Cavia porcellus), on a hay-only diet.

    PubMed

    Franz, R; Kreuzer, M; Hummel, J; Hatt, J-M; Clauss, M

    2011-10-01

    A colonic separation mechanism (CSM) is the prerequisite for the digestive strategy of coprophagy. Two different CSM are known in small herbivores, the 'wash-back' CSM of lagomorphs and the 'mucous-trap' CSM of rodents. Differences between these groups in their digestive pattern when fed exclusively hay were investigated in six rabbits (Oryctolagus cuniculus) and six guinea pigs (Cavia porcellus). Intake, digestibility (by total faecal collection), solute and particle mean retention times (MRT, using Co-EDTA and Cr-mordanted fibres) were measured. Rabbits selected less fibrous parts of the hay than guinea pigs, leaving orts with higher content of neutral detergent fibre [NDF; 721 ± 21 vs. 642 ± 31 g/kg dry matter (DM) in guinea pigs]. They also expressed a lower NDF digestibility (0.44 ± 0.10 vs. 0.55 ± 0.05 of total), a similar particle MRT (15 ± 3 vs. 18 ± 6 h), a longer solute MRT (51 ± 9 vs. 16 ± 4 h), and a lower calculated dry matter gut fill (19.6 ± 4.7 vs. 29.7 ± 4.1 g DM/kg body mass) than guinea pigs (p < 0.05 for each variable). These results support the assumption that the 'wash-back' CSM, exhibited in the rabbits, is more efficient in extracting bacterial matter from the colonic digesta plug than the 'mucous-trap' CSM found in the guinea pigs. Related to metabolic body mass, rabbits therefore need a less capacious colon for their CSM where a more efficient bacteria wash-out is reflected in the lower fibre digestibility. A lighter digestive tract could contribute to a peculiarity of lagomorphs: their ability to run faster than other similar-sized mammals. PMID:21091550

  15. Successful eradication of the European rabbit (Oryctolagus cuniculus) and house mouse (Mus musculus) from the island of Selvagem Grande (Macaronesian archipelago), in the Eastern Atlantic.

    PubMed

    Olivera, Paulo; Menezes, Dilia; Trout, Roger; Buckle, Alan; Geraldes, Pedro; Jesus, José

    2010-03-01

    The Portuguese island of Selvagem Grande (Great Salvage) in Macaronesia is an important seabird breeding station in the eastern Atlantic. Significant populations of Cory's shearwater Calonectris diomedea (Scopoli, 1769), Bulwer's petrel Bulweria bulweria (Jardine & Selby, 1828) and little shearwater Puffinus assimilis baroli (Bonaparte, 1857) are present, and white-faced storm-petrel Pelagodroma marina (Latham, 1790) and Madeiran storm-petrel Oceanodroma castro (Harcourt, 1851) populations are of global significance. Selvagem Grande also provides diverse habitats for an extensive flora, including 11 endemic species. The 270-ha island was also inhabited by two alien invasive mammals: the European rabbit Oryctolagus cuniculus (Linnaeus, 1758) and the house mouse Mus musculus (Linnaeus, 1758). Both are known to have had adverse impacts on breeding seabirds and island vegetation. In 2002, the Natural Park of Madeira conducted a program using brodifacoum bait formulations aimed at rabbit and mouse eradication. Approximately 17 000 individual baiting points were established on a 12.5 × 12.5 m grid. Baits were also applied by hand "seeding" on steep slopes and cliffs where bait stations could not be placed. Rabbits were removed after a month. However, mice persisted for considerably longer and strategic bait applications against them continued for a further six months. Subsequent assessments by trapping, bait takes and systematic observation of signs over three years, has confirmed the removal of both alien invasive species. This paper presents information on these operations, on measures adopted to mitigate adverse impacts of the eradication program on important vertebrate non-target species, including Berthelot's pipit Anthus berthelotii Bolle, 1862 and a species of gecko Tarentola bischoffi Joger, 1984 and on the initial response of the island's ecosystem to the eradication of rabbits and mice. PMID:21392324

  16. Assessing Animal Welfare Impacts in the Management of European Rabbits (Oryctolagus cuniculus), European Moles (Talpa europaea) and Carrion Crows (Corvus corone)

    PubMed Central

    Baker, Sandra E.; Sharp, Trudy M.; Macdonald, David W.

    2016-01-01

    Human-wildlife conflict is a global issue. Attempts to manage this conflict impact upon wild animal welfare, an issue receiving little attention until relatively recently. Where human activities harm animal welfare these effects should be minimised where possible. However, little is known about the welfare impacts of different wildlife management interventions, and opinions on impacts vary widely. Welfare impacts therefore need to be assessed objectively. Our objectives were to: 1) establish whether an existing welfare assessment model could differentiate and rank the impacts of different wildlife management interventions (for decision-making purposes); 2) identify and evaluate any additional benefits of making formal welfare assessments; and 3) illustrate issues raised by application of the model. We applied the welfare assessment model to interventions commonly used with rabbits (Oryctolagus cuniculus), moles (Talpa europaea) and crows (Corvus corone) in the UK. The model ranked interventions for rabbits (least impact first: fencing, head shot, chest shot) and crows (shooting, scaring, live trapping with cervical dislocation). For moles, managing molehills and tunnels scored least impact. Both spring trapping, and live trapping followed by translocation, scored greater impacts, but these could not be compared directly as they scored on different axes of the model. Some rankings appeared counter-intuitive, highlighting the need for objective formal welfare assessments. As well as ranking the humaneness of interventions, the model highlighted future research needs and how Standard Operating Procedures might be improved. The model is a milestone in assessing wildlife management welfare impacts, but our research revealed some limitations of the model and we discuss likely challenges in resolving these. In future, the model might be developed to improve its utility, e.g. by refining the time-scales. It might also be used to reach consensus among stakeholders about

  17. Area deprivation and the food environment over time: A repeated cross-sectional study on takeaway outlet density and supermarket presence in Norfolk, UK, 1990–2008

    PubMed Central

    Maguire, Eva R.; Burgoine, Thomas; Monsivais, Pablo

    2015-01-01

    Socioeconomic disparities in the food environment are known to exist but with little understanding of change over time. This study investigated the density of takeaway food outlets and presence of supermarkets in Norfolk, UK between 1990 and 2008. Data on food retail outlet locations were collected from telephone directories and aggregated within electoral wards. Supermarket presence was not associated with area deprivation over time. Takeaway food outlet density increased overall, and was significantly higher in more deprived areas at all time points; furthermore, socioeconomic disparities in takeaway food outlet density increased across the study period. These findings add to existing evidence and help assess the need for environmental interventions to reduce disparities in the prevalence of unhealthy food outlets. PMID:25841285

  18. A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers

    PubMed Central

    Benton, Miles C.; Lea, Rodney A.; Macartney-Coxson, Donia; Hanna, Michelle; Eccles, David A.; Carless, Melanie A.; Chambers, Geoffrey K.; Bellis, Claire; Goring, Harald H.; Curran, Joanne E.; Harper, Jacquie L.; Gibson, Gregory; Blangero, John; Griffiths, Lyn R.

    2015-01-01

    Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced phenotypes for GWAS analysis. In this study we performed a principal component analysis (PCA), heritability (h2) estimation and pedigree-based GWAS of 37 cardiovascular disease -related phenotypes in 330 related individuals forming a large pedigree from the Norfolk Island genetic isolate. PCA revealed 13 components explaining >75% of the total variance. Nine components yielded statistically significant h2 values ranging from 0.22 to 0.54 (P<0.05). The most heritable component was loaded with 7 phenotypic measures reflecting metabolic and renal dysfunction. A GWAS of this composite phenotype revealed statistically significant associations for 3 adjacent SNPs on chromosome 1p22.2 (P<1x10-8). These SNPs form a 42kb haplotype block and explain 11% of the genetic variance for this renal function phenotype. Replication analysis of the tagging SNP (rs1396315) in an independent US cohort supports the association (P = 0.000011). Blood transcript analysis showed 35 genes were associated with rs1396315 (P<0.05). Gene set enrichment analysis of these genes revealed the most enriched pathway was purine metabolism (P = 0.0015). Overall, our findings provide convincing evidence for a major pleiotropic effect locus on chromosome 1p22.2 influencing risk of renal dysfunction via purine metabolism pathways in the Norfolk Island population. Further studies are now warranted to interrogate the functional relevance of this locus in terms of renal pathology and cardiovascular disease risk. PMID:26474483

  19. Demersal fish distribution and habitat use within and near Baltimore and Norfolk Canyons, U.S. Middle Atlantic Slope

    USGS Publications Warehouse

    Ross, Steve W.; Rhode, Mike; Quattrini, Andrea M.

    2015-01-01

    Numerous submarine canyons along the United States middle Atlantic continental margin support enhanced productivity, diverse and unique habitats, active fisheries, and are vulnerable to various anthropogenic disturbances. During two cruises (15 Aug–2 Oct 2012 and 30 Apr–27 May 2013), Baltimore and Norfolk canyons and nearby areas (including two cold seeps) were intensively surveyed to determine demersal fish distributions and habitat associations. Overall, 34 ROV dives (234–1612 m) resulted in 295 h of bottom video observations and numerous collections. These data were supplemented by 40, 30-min bottom trawl samples. Fish observations were assigned to five general habitat designations: 1) sand-mud (flat), 2) sloping sand-mud with burrows, 3) low profile gravel, rock, boulder, 4) high profile, canyon walls, rocks or ridges, and 5) seep-mixed hard and soft substrata, the later subdivided into seven habitats based on amounts of dead mussel and rock cover. The influence of corals, sponges and live mussels (seeps only) on fish distributions was also investigated. Both canyon areas supported abundant and diverse fish communities and exhibited a wide range of habitats, including extensive areas of deep-sea corals and sponges and two nearby methane seeps (380–430 m, 1455–1610 m). All methods combined yielded a total of 123 species of fishes, 12 of which are either new records for this region or have new range data. Depth was a major factor that separated the fish faunas into two zones with a boundary around 1400 m. Fishes defining the deeper zone included Lycodes sp.,Dicrolene introniger, Gaidropsaurus ensis, Hydrolagus affinis, Antimora rostrata, andAldrovandia sp. Fishes in the deep zone did not exhibit strong habitat affinities, despite the presence of a quite rugged, extensive methane seep. We propose that habitat specificity decreases with increasing depth. Fishes in the shallower zone, characterized by Laemonema sp., Phycis chesteri, Nezumia bairdii, Brosme

  20. NORFOLK'S VENTURE INTO EMPATHY.

    ERIC Educational Resources Information Center

    STEVENS, WILLIAM K.

    IN 1962, 43 FIRST-GRADE NEGRO CHILDREN IN AN INNER CITY SCHOOL WERE ENROLLED IN A SPECIAL EDUCATIONAL PROGRAM. TEACHERS VISITED PUPILS' HOMES, LEARNED THEIR SPECIAL INTERESTS, AND DEVELOPED CLOSE PERSONAL RELATIONSHIPS WITH THEM. THE PUPILS ENGAGED IN VARIOUS ENRICHMENT ACTIVITIES AND LEARNED LANGUAGE SKILLS. THEY WERE TAUGHT IN "FLUID" GROUPS,…

  1. Insights into the European rabbit (Oryctolagus cuniculus) innate immune system: genetic diversity of the toll-like receptor 3 (TLR3) in wild populations and domestic breeds

    PubMed Central

    2013-01-01

    Background Toll-like receptors (TLRs) belong to the innate immune system and are a major class of pattern recognition receptors representing the first line of the innate immune response. The TLR molecule is structurally composed by an ectodomain that contains leucine rich repeats (LRRs) that interact with pathogen associated molecular patterns (PAMPs), a transmembrane domain and a conserved cytoplasmic domain designated TIR (Toll-IL1 receptor) that is responsible for the intracellular signaling. TLR3 has been associated with the direct recognition of double-stranded viral RNA resulting from viral replication, while TLR7 and TLR8 target single-stranded viral RNA. In the European rabbit (Oryctolagus cuniculus), TLR7 and TLR8 were reported to be absent and pseudogenised, respectively, making TLR3 the only available TLR for the recognition of viral RNA. Thus, the levels of diversity of TLR3 were evaluated in the European rabbit by analysing different genetic backgrounds and exposure to pathogen pressures. Results We detected 41 single nucleotide polymorphisms (SNPs) in the coding sequence of TLR3. The highest diversity was observed in the wild populations of Iberian Peninsula, between 22–33 polymorphic positions. In the French population, 18 SNPs were observed and only 4 polymorphic positions were detected in the domestic breeds. 14 non-synonymous substitutions were observed, most of them in the LRR molecules. The remaining were scattered across the transmembrane and TIR domains. Conclusion The study of TLR3 in European rabbit populations might be relevant to understand the interplay between RNA viruses and innate immunity. Wild rabbit populations presented more diversity than domestic breeds and other mammals previously studied. This might be linked to the absence of population bottlenecks during their evolution and to the almost inexistence of man-mediated selection. The observed variability might have also been potentiated by the contact of the wild populations

  2. Geothermal energy development in the eastern United States: technical assistance report no. 5. Geothermal space heating-naval air rework facility, Norfolk, Virginia. [Aircraft hangers

    SciTech Connect

    Hill, F.K.; Henderson, R.W.

    1980-06-01

    The electronic integration hangar, designated LP-167, was selected for study, as it was a single-story building with a large floor area. Because of the high ceiling and the sliding doors necessary to admit aircraft, the heat loss rate, based on floor area, was about twice that of commercial buildings. It was furnished with an oil-fired hot water heating system capable of high thermal output to meet heating requirements in the coldest weather. On the basis of the known characteristics of geothermal sources for the Atlantic Coastal Plain, and wells drilled and assayed in the Norfolk area, a reasonable estimate of the parameters of a well drilled at NARF was made. This included a low temperature output from the well of only 107/sup 0/F, so that direct transfer of warm water between the wellhead heat exchanger (HX) and the hot water radiating system in the building was not practical. Four design options are explored and calculations are presented on each one.

  3. Digital data and derivative products from a high-resolution aeromagnetic survey of the central San Luis basin, covering parts of Alamosa, Conejos, Costilla, and Rio Grande counties, Colorado, and Taos county, New Mexico

    USGS Publications Warehouse

    Bankey, Viki; Grauch, V.J.S.; Webbers, Ank; PRJ, Inc

    2005-01-01

    This report describes data collected from a high-resolution aeromagnetic survey flown over the central San Luis basin during October, 2004, by PRJ, Inc., on contract to the U.S. Geological Survey (USGS). The survey extends from just north of Alamosa, Colorado, southward to just northwest of Taos, New Mexico. It covers large parts of the San Luis Valley in Alamosa, Conejos, Costilla, and Rio Grande Counties, southern Colorado, and the Taos Plateau in Taos County, northern New Mexico. The survey was designed to complement two surveys previously acquired along the eastern borders of the San Luis Basin over the vicinities of Taos, New Mexico (Bankey and others, 2004a) and Blanca, Colorado (Bankey and others, 2004b). Our overall objective in conducting these surveys is to improve knowledge of the subsurface geologic framework in order to understand ground-water systems in populated alluvial basins along the Rio Grande. These USGS efforts are conducted in collaboration with other federal, state, and local governmental entities where possible.

  4. Predictors and outcomes of sustained, intermittent or never achieving remission in patients with recent onset inflammatory polyarthritis: results from the Norfolk Arthritis Register

    PubMed Central

    Cook, Michael J.; Diffin, Janet; Scirè, Carlo A.; Lunt, Mark; MacGregor, Alex J.; Symmons, Deborah P. M.

    2016-01-01

    Objectives. Early remission is the current treatment strategy for patients with inflammatory polyarthritis (IP) and RA. Our objective was to identify baseline factors associated with achieving remission: sustained (SR), intermittent (IR) or never (NR) over a 5-year period in patients with early IP. Methods. Clinical and demographic data of patients with IP recruited to the Norfolk Arthritis Register (NOAR) were obtained at baseline and years 1, 2, 3 and 5. Remission was defined as no tender or swollen joints (out of 51). Patients were classified as NR or PR, respectively, if they were in remission at: no assessment or ⩾3 consecutive assessments after baseline, and IR otherwise. Ordinal regression and a random effects model, respectively, were used to examine the association between baseline factors, remission group and HAQ scores over time. Results. A total of 868 patients (66% female) were included. Of these, 54%, 34% and 12% achieved NR, IR and SR, respectively. In multivariate analysis, female sex (odds ratio, OR 0.47, 95% CI: 0.35, 0.63), higher tender joint count (OR = 0.94, 95% CI: 0.93, 0.96), higher HAQ (OR = 0.59, 95% CI: 0.48, 0.74), being obese (OR = 0.70, 95% CI: 0.50, 0.99), hypertensive (OR = 0.67, 95% CI: 0.50, 0.90) or depressed (OR = 0.74, 95% CI: 0.55, 1.00) at baseline were independent predictors of being in a lower remission group. IR and SR were associated with lower HAQ scores over time and lower DAS28 at year 5. Conclusion. Women with higher tender joint count and disability at baseline, depression, obesity and hypertension were less likely to achieve remission. This information could help when stratifying patients for more aggressive therapy. PMID:27220594

  5. Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study.

    PubMed

    Verbeek, Rutger; Boekholdt, S Matthijs; Stoekenbroek, Robert M; Hovingh, G Kees; Witztum, Joseph L; Wareham, Nicholas J; Sandhu, Manjinder S; Khaw, Kay-Tee; Tsimikas, Sotirios

    2016-04-01

    Variable agreement exists between different lipoprotein (a) [Lp(a)] measurement methods, but their clinical relevance remains unclear. The predictive value of Lp(a) measured by two different assays [Randox and University of California, San Diego (UCSD)] was determined in 623 coronary artery disease (CAD) cases and 948 controls in a case-control study within the EPIC-Norfolk Prospective Population Study. Participants were divided into sex-specific quintiles, and by Lp(a) <50 versus ∼50 mg/dl, which represents the 80th percentile in northern European subjects. Randox and UCSD Lp(a) levels were strongly correlated; Spearman's correlation coefficients for men, women, and sexes combined were 0.905, 0.915, and 0.909, respectively (P< 0.001 for each). The >80th percentile cutoff values, however, were 36 mg/dl and 24 mg/dl for the Randox and UCSD assays, respectively. Despite this, Lp(a) levels were significantly associated with CAD risk, with odds ratios of 2.18 (1.58-3.01) and 2.35 (1.70-3.26) for people in the top versus bottom Lp(a) quintile for the Randox and UCSD assays, respectively. This study demonstrates that CAD risk is present at lower Lp(a) levels than the currently suggested optimal Lp(a) level of <50 mg/dl. Appropriate thresholds may need to be population and assay specific until Lp(a) assays are standardized and Lp(a) thresholds are evaluated broadly across all populations at risk for CVD and aortic stenosis. PMID:26828068

  6. Cross Sectional and Longitudinal Associations between Cardiovascular Risk Factors and Age Related Macular Degeneration in the EPIC-Norfolk Eye Study

    PubMed Central

    Yip, Jennifer L. Y.; Khawaja, Anthony P.; Chan, Michelle P. Y.; Broadway, David C.; Peto, Tunde; Tufail, Adnan; Luben, Robert; Hayat, Shabina; Bhaniani, Amit; Wareham, Nicholas J.; Khaw, Kay-Tee; Foster, Paul J.

    2015-01-01

    Purpose To examine the cross sectional and longitudinal relationship between cardiovascular risk factors and age-related macular degeneration (AMD) in a large British cohort study. Methods The EPIC Norfolk Eye study is nested in a larger prospective cohort study. Data on cardiovascular risk factors were collected at baseline (1993-1997) and follow up (2006-2011) via clinical examination, validated lifestyle questionnaires and serum blood samples. AMD was ascertained using standardised grading of fundus photographs at the follow up. Logistic regression was used to examine associations between baseline and follow up risk factors with AMD. Results 5,344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD in participants with mean age of 67.4 years old (range 44-91) at diagnosis. There were 28 cases of late AMD (0.5%, 95% confidence interval (CI)=0.3-0.8%) and 645 cases of early AMD (12.1%, 95%CI=11.2-13.0.%). In multivariable analysis, older people with higher levels of baseline high density lipoprotein- cholesterol (HDL-C ) and C-reactive protein (CRP) were more likely to have any signs of AMD, after adjusting for sex, education, smoking, and systolic blood pressure. In cross sectional analysis, only older age and higher HDL were significantly associated with AMD. Conclusions We have found that older age and higher levels of CRP and HDL-C were associated with increased odds of AMD in this population in the longitudinal analysis, but older age and HDL-C, not CRP was significantly associated with AMD in the cross sectional analysis. The prevalence of AMD in this cohort was low compared to other cohorts in Europe, the US and Australia, and probably reflects the some selection biases in follow up participation as well as the low rate of smoking among our healthy participants. PMID:26176222

  7. Parapercis nigrodorsalis (Perciformes: Pinguipedidae), a new species of sandperch from northern New Zealand and the Norfolk Ridge, Tasman Sea and remarks on P. binivirgata (Waite, 1904).

    PubMed

    Johnson, Jeffrey W; Struthers, Carl D; Wilmer, Jessica Worthington

    2014-01-01

    A new species of pinguipedid fish, Parapercis nigrodorsalis, is described from 17 specimens collected off the North Island of New Zealand and Wanganella Bank, Norfolk Ridge, Tasman Sea, in depths of 56-280 m. The species has also been photographed underwater off the Poor Knights Islands Reserve and Burgess Island, Mokohinau Group, in New Zealand. It is most similar to Parapercis binivirgata (Waite, 1904) in morphology, coloration and meristic values, but is unique among the genus in having a combination of dorsal-fin rays V, 23, anal-fin rays I, 19, lateral-line scales 57-63, vomer with 1-2 irregular rows of robust conical teeth, palatines with 1-2 rows of small teeth, angle of subopercle smooth, 10 abdominal and 22 caudal vertebrae, and coloration, including seven broad reddish-brown bands on the upper body between the spinous dorsal-fin and the caudal peduncle, most bands bifurcated into close-set double bars with black smudge-like blotches below, and membrane of the spinous dorsal fin black. Comparison of the mitochondrial cytochrome c oxidase subunit 1 (CO 1) genetic marker utilised in DNA barcoding produced a genetic divergence of 5.38% and 7.63% between the new species and its two closest sampled congeners. The holotype of P. binivirgata is identified from two specimens previously regarded as syntypes, some revisions are made to meristic data in the original description of the latter, and a detailed description of the revised geographic range of P. binivirgata is provided.   PMID:25284671

  8. Predicting admissions and time spent in hospital over a decade in a population-based record linkage study: the EPIC-Norfolk cohort

    PubMed Central

    Hayat, Shabina; Khaw, K T

    2016-01-01

    Objective To quantify hospital use in a general population over 10 years follow-up and to examine related factors in a general population-based cohort. Design A prospective population-based study of men and women. Setting Norfolk, UK. Participants 11 228 men and 13 786 women aged 40–79 years in 1993–1997 followed between 1999 and 2009. Main outcomes measures Number of hospital admissions and total bed days for individuals over a 10-year follow-up period identified using record linkage; five categories for admissions (from zero to highest ≥7) and hospital bed days (from zero to highest ≥20 nights). Results Over a period of 10 years, 18 179 (72.7%) study participants had at least one admission to hospital, 13.8% with 7 or more admissions and 19.9% with 20 or more nights in hospital. In logistic regression models with outcome ≥7 admissions, low education level OR 1.14 (1.05 to 1.24), age OR per 10-year increase 1.75 (1.67 to 1.82), male sex OR 1.32 (1.22 to 1.42), manual social class 1.22 (1.13 to 1.32), current cigarette smoker OR 1.53 (1.37 to 1.71) and body mass index >30 kg/m² OR 1.41 (1.28 to 1.56) all independently predicted the outcome with p<0.0001. Results were similar for those with ≥20 hospital bed days. A risk score constructed using male sex, manual social class, no educational qualifications; current smoker and body mass index >30 kg/m², estimated percentages of the cohort in the categories of admission numbers and hospital bed days in stratified age bands with twofold to threefold differences in future hospital use between those with high-risk and low-risk scores. Conclusions The future probability of cumulative hospital admissions and bed days appears independently related to a range of simple demographic and behavioural indicators. The strongest of these is increasing age with high body mass index and smoking having similar magnitudes for predicting risk of future hospital usage. PMID:26792216

  9. Marital transitions and associated changes in fruit and vegetable intake: Findings from the population-based prospective EPIC-Norfolk cohort, UK

    PubMed Central

    Vinther, Johan L.; Conklin, Annalijn I.; Wareham, Nicholas J.; Monsivais, Pablo

    2016-01-01

    Background Diet is critical to health and social relationships are an important determinant of diet. We report the association between transitions in marital status and healthy eating behaviours in a UK population. Methods Longitudinal study of middle-age and older adults 39−78y (n = 11 577) in EPIC-Norfolk, a population-based cohort, who completed food frequency questionnaires in 1993–97 and 1998–2002. Multivariable linear regression analyses assessed gender-specific associations between five categories of marital transitions and changes in quantity (g/d), and variety (no/month) of fruits or vegetables. Results In 3.6 years of follow-up and relative to men who stayed married, widowed men showed significant declines (mean difference, 95% CI) in all four indicators of healthy eating including fruit quantity (−47.7, −80.6 to −14.9 g/d), fruit variety (−0.6, −1.1 to −0.2 no/month), vegetable quantity (−27.7, −50.5 to −4.9 g/d), and vegetable variety (−1.6, −2.2 to −0.9 no/month). Men who were separated or divorced or who remained single also showed significant declines in three of the indicators. Among women, only those who became separated/divorced or stayed single showed declines in one indicator, vegetable variety. Conclusion Unhealthy changes to diet accompanying divorce, separation and becoming widowed may be more common among men than women. Moreover, deterioration in fruit and vegetable intakes was more apparent for variety rather than quantity consumed. Programmes to promote healthy eating among older adults need to recognise these social determinants of diet and consider prioritising people who live alone and in particular men who have recently left relationships or who have been widowed. PMID:27082023

  10. Genetic variation at chemokine receptor CCR5 in leporids: alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus, but not in Sylvilagus and Lepus species.

    PubMed

    Carmo, C R; Esteves, P J; Ferrand, N; van der Loo, W

    2006-06-01

    Whereas in its natural host (Sylvilagus sps.) the effects of myxoma virus infections are benign, in European rabbit (Oryctolagus cuniculus), it causes a highly infectious disease with very high mortality rate, known as myxomatosis. There is evidence that, as with HIV-1 virus in human, myxoma virus may use chemokine receptors such as CCR5 of the host target cell for entry and activation of pathways of immune avoidance. We have characterized and compared CCR5 genes of leporid species with different susceptibility levels to myxomatosis. The CCR5 protein of O. cuniculus differs markedly from all those known from other species. The most striking was the replacement of a specific peptide motif of the second extracellular loop (ECL2) by a motif, which in other species characterizes the CCR2 molecules. While absent in Sylvilagus and Lepus species, this CCR2 imposed CCR5-ECL2 alteration was observed in all genomes of 25 European rabbits, representing the subspecies O. cuniculus algirus and O. cuniculus cuniculus. Allelic variation at the rabbit CCR5 locus confirmed that the gene conversion predates the subspecies split (1-2 Ma). PMID:16596402

  11. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. III. Release, persistence and rate of spread of an identifiable strain of myxoma virus.

    PubMed

    Merchant, J C; Kerr, P J; Simms, N G; Hood, G M; Pech, R P; Robinson, A J

    2003-02-01

    An identifiable strain of myxoma virus was introduced into four local populations of wild rabbits Oryctolagus cuniculus on the southern tablelands of New South Wales (NSW) and its spread in the presence of other field strains was monitored for 6 months. The main vector in this region was considered to be the European rabbit flea Spilopsyllis cuniculi. Each population of rabbits was of a high density and living in groups of warrens covering areas from 59 to 87 hectares. Rabbits occupying centrally located warrens were inoculated with the virus in late September or early October (spring) and the subsequent appearance of myxomatosis across the sites monitored by trapping, shooting and visual observations. Samples, taken from rabbits with myxomatosis, were examined by polymerase chain reaction (PCR) that allowed identification of the introduced strain. On all four sites the introduced virus spread from the inoculated rabbits in the centrally located warrens to rabbits in surrounding warrens. On Sites 1 and 3, this spread continued across the entire site persisting for at least 118 and 174 days respectively. On Sites 2 and 4, the virus was detected for 78 and 62 days respectively and the subsequent inability to detect the introduced virus correlated with the appearance of an unrelated field strain. Using three different methods of calculation, rates of spread ranged from 3.7 to 17.8 m d(-1). PMID:12613755

  12. Flood-inundation maps for Peachtree Creek from the Norfolk Southern Railway bridge to the Moores Mill Road NW bridge, Atlanta, Georgia

    USGS Publications Warehouse

    Musser, Jonathan W.

    2012-01-01

    Digital flood-inundation maps for a 5.5-mile reach of the Peachtree Creek from the Norfolk Southern Railway bridge to the Moores Mill Road NW bridge, were developed by the U.S. Geological Survey (USGS) in cooperation with the City of Atlanta, Georgia. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Peachtree Creek at Atlanta, Georgia (02336300) and the USGS streamgage at Chattahoochee River at Georgia 280, near Atlanta, Georgia (02336490). Current water level (stage) at these USGS streamgages may be obtained at http://waterdata.usgs.gov/ and can be used in conjunction with these maps to estimate near real-time areas of inundation. The National Weather Service (NWS) is incorporating results from this study into the Advanced Hydrologic Prediction Service (AHPS) flood warning system (http:/water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that commonly are collocated at USGS streamgages. The forecasted peak-stage information for the USGS streamgage at Peachtree Creek, which is available through the AHPS Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. A one-dimensional step-backwater model was developed using the U.S. Army Corps of Engineers HEC–RAS software for a 6.5-mile reach of Peachtree Creek and was used to compute flood profiles for a 5.5-mile reach of the creek. The model was calibrated using the most current stage-discharge relations at the Peachtree Creek at Atlanta, Georgia, streamgage (02336300), and the Chattahoochee River at Georgia 280, near Atlanta, Georgia, streamgage (02336490) as well as high water marks collected during the 2010 annual peak flow event. The hydraulic model was then used to determine 50 water

  13. A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus)

    PubMed Central

    2010-01-01

    Background In the domestic rabbit (Oryctolagus cuniculus), classical genetic studies have identified five alleles at the Extension locus: ED (dominant black), ES (steel, weaker version of ED), E (wild type, normal extension of black), eJ(Japanese brindling, mosaic distribution of black and yellow) and e (non-extension of black, yellow/red with white belly). Sequencing almost the complete coding sequence (CDS) of the rabbit MC1R gene, we recently identified two in-frame deletions associated with dominant black (c.280_285del6; alleles ED or ES) and recessive red (c.304_333del30; allele e) coat colours. It remained to characterize the eJallele whose phenotypic effect is similar to the Orange and Sex-linked yellow loci of cat and Syrian hamster. Results We sequenced the whole CDS in 25 rabbits of different coat colours including 10 Japanese and 10 Rhinelander (tricolour) rabbits and identified another 6 bp-in frame deletion flanked by a G > A transition in 5' (c.[124G>A;125_130del6]) that was present in all animals with Japanese brindling coat colour and pattern. These mutations eliminate two amino acids in the first transmembrane domain and, in addition, cause an amino acid substitution at position 44 of the wild type sequence. Genotyping 371 rabbits of 31 breeds with different coat colour this allele (eJ) was present in homozygous state in Japanese, Rhinelander and Dutch tricolour rabbits only (except one albino rabbit). Rabbits with eJ/eJ genotype were non fixed at the non-agouti mutation we previously identified in the ASIP gene. Segregation in F1 and F2 families confirmed the order of dominance already determined by classical genetic experiments with a possible dose effect evident comparing eJ/eJ and eJ/e animals. MC1R mRNA was expressed in black hair skin regions only. Conclusions The c.[124A;125_130del6] allele may be responsible for a MC1R variant determining eumelanin production in the black areas. However, the mechanism determining the presence of both red

  14. Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study.

    PubMed

    Ravandi, Amir; Boekholdt, S Matthijs; Mallat, Ziad; Talmud, Philippa J; Kastelein, John J P; Wareham, Nicholas J; Miller, Elizabeth R; Benessiano, Joelle; Tedgui, Alain; Witztum, Joseph L; Khaw, Kay-Tee; Tsimikas, Sotirios

    2011-10-01

    Levels of IgG and IgM autoantibodies (AA) to malondialdehyde (MDA)-LDL and apoB-immune complexes (ICs) were measured in 748 cases and 1,723 controls in the EPIC-Norfolk cohort and their association to coronary artery disease (CAD) events determined. We evaluated whether AA and IC modify CAD risk associated with secretory phospholipase A(2) (sPLA(2)) type IIA mass and activity, lipoprotein-associated PLA(2) activity, lipoprotein (a) [Lp(a)], oxidized phospholipids on apoB-100 (OxPL/apoB), myeloperoxidase, and high sensitivity C-reactive protein. IgG ICs were higher in cases versus controls (P = 0.02). Elevated levels of IgM AA and IC were inversely associated with Framingham Risk Score and number of metabolic syndrome criteria (p range 0.02-0.001). In regression analyses adjusted for age, smoking, diabetes, LDL-cholesterol, HDL-cholesterol, and systolic blood pressure, the highest tertiles of IgG and IgM AA and IC were not associated with higher risk of CAD events compared with the lowest tertiles. However, elevated levels of IgM IC reduced the risk of Lp(a) (P = 0.006) and elevated IgG MDA-LDL potentiated the risk of sPLA(2) mass (P = 0.018). This epidemiological cohort of initially healthy subjects shows that IgG and IgM AA and IC are not independent predictors of CAD events but may modify CAD risk associated with elevated levels of oxidative biomarkers. PMID:21821825

  15. Paracoccidioides brasiliensis infection in domestic rabbits (Oryctolagus cuniculus).

    PubMed

    Belitardo, Donizeti Rodrigues; Calefi, Atilio Sersun; Sbeghen, Mônica Raquel; de Oliveira, Gabriela Gonçalves; Watanabe, Maria Angelica Ehara; de Camargo, Zoilo Pires; Ono, Mario Augusto

    2014-04-01

    The objective of this study was to evaluate the infection of domestic rabbits by Paracoccidioides brasiliensis. Initially two rabbits were experimentally infected with P. brasiliensis and the humoral immune response was evaluated by ELISA using gp43 as antigen. The two animals showed IgG response against gp43 although no signs of disease were observed. The seroepidemiological study was carried out in 170 rabbits (free range n = 81 and caged n = 89) living in an endemic area for human paracoccidioidomycosis and a positivity of 27% was observed in the ELISA using gp43 as antigen. The free-range rabbits showed a significantly higher positivity (34.6-51.7%) than the caged animals (11.1%). Sentinel rabbits exposed to natural infection with P. brasiliensis were followed up for 6 months and a seroconversion rate of 83.3% was observed. This is the first report of paracoccidioidomycosis in rabbits and suggests that this species can be useful sentinels for P. brasiliensis presence in the environment. PMID:24125519

  16. Health survey of 167 pet rabbits (Oryctolagus cuniculus) in Finland.

    PubMed

    Mäkitaipale, J; Harcourt-Brown, F M; Laitinen-Vapaavuori, O

    2015-10-24

    Only a limited amount of information is available about health status of pet rabbits. The aim of this study was to obtain data about the health status of pet rabbits considered healthy by the owners in Finland. Physical examination and lateral abdominal and lateral skull radiography were performed on 167 pet rabbits of which 118 (70.7 per cent) had abnormal findings in at least one examination. The most common findings were acquired dental disease (n=67, 40.1 per cent), vertebral column deformities and degenerative lesions (n=52, 31.1 per cent), skin disorders (n=28, 16.8 per cent) and eye disorders (n=12, 7.2 per cent). Vertebral column angulating deformities were significantly more common in dwarf lop rabbits (P≤0.001). The prevalence of health disorders was significantly higher in rabbits over three years of age of which 51 (82.3 per cent) had findings in at least one examination (P<0.05). Rabbits as prey animals hide their illness, which cause difficulties to owners to recognise health problems. Because of the high prevalence of clinical and radiological findings in apparently healthy pet rabbits, regular physical examinations are advised, especially for animals over three years old. PMID:26475828

  17. Deliberate introduction of the European rabbit, Oryctolagus cuniculus, into Australia.

    PubMed

    Fenner, F

    2010-04-01

    The European rabbit was brought to Australia as a companion animal by early settlers. It sometimes escaped, but failed to survive in the Australian bush. In 1879 wild rabbits were deliberately sent to Victoria to provide game for wealthy settlers to shoot. They soon spread all over Australia, except in the tropics, and became Australia's major animal pest. After careful testing in Australian wildlife and in humans, control by myxoma virus was introduced at various sites between 1937 and 1950, spreading all over the Murray-Darling Basin in 1950. Within one year mutations in the virus had led to slightly less virulence, and these continued for the next 50 years. In the early 21st Century testing viruses obtained from wild rabbits showed that the majority of these viruses were more virulent than the virus used to initiate the epidemic. In 1995 another virus specific for European rabbits, rabbit haemorrhagic disease virus, escaped from areas in which field trials were being carried out and spread around Australia. It was more successful than myxomatosis for rabbit control in arid regions. PMID:20617651

  18. Herpes simplex encephalitis in a domestic rabbit (Oryctolagus cuniculus).

    PubMed

    Grest, P; Albicker, P; Hoelzle, L; Wild, P; Pospischil, A

    2002-05-01

    An adult domestic rabbit showing neurological signs was subjected to euthanasia. At necropsy, macroscopical lesions were absent. Histopathologically, extensive lesions were seen, particularly in the cerebral cortex. Non-suppurative meningitis was present and there was lymphocytic and plasmacytic perivascular cuffing in the neuropil. The cerebral cortex showed extensive segmental neuronal and glial necrosis. Within the necrotic areas, large amphophilic intranuclear inclusion bodies were present in neurons and glial cells. Immunohistochemically, neurons and glial cells in the affected areas were labelled by polyclonal antibodies against both herpes simplex virus-1 (HSV-1) and HSV-2. The agent was classified as HSV-1 by polymerase chain reaction analysis. This is only the second reported natural case of herpes simplex infection in a rabbit. PMID:12056779

  19. Welfare Impacts of Pindone Poisoning in Rabbits (Oryctolagus cuniculus)

    PubMed Central

    Fisher, Penny; Brown, Samantha; Arrow, Jane

    2016-01-01

    Simple Summary The nature and duration of the effects of pindone poisoning in rabbits were evaluated through observational monitoring of affected animals and necropsy. Using the resulting data in a formal assessment framework, the welfare impacts of pindone poisoning were ranked as relatively higher than other vertebrate toxic agents currently used for rabbit control. Abstract Control methods used to manage unwanted impacts of the European rabbit in Australia and New Zealand include the use of toxic bait containing the anticoagulant pindone. Towards increased certainty in evaluating the animal welfare impacts of pindone poisoning in rabbits, we recorded behavioral and post-mortem data from rabbits which ingested lethal quantities of pindone bait in a laboratory trial. Pindone poisoning in rabbits resulted in welfare compromise, primarily through functional impairments related to internal haemorrhage over a maximum duration of 7 days. Applying this data to a formal assessment framework for ranking animal welfare impacts indicated that pindone had relatively high severity and also duration of welfare impacts in comparison to other rabbit control methods. PMID:26927192

  20. Cutaneous lymphomas in European pet rabbits (Oryctolagus cuniculus).

    PubMed

    Ritter, J M; von Bomhard, W; Wise, A G; Maes, R K; Kiupel, M

    2012-09-01

    Cutaneous lymphoma is a common skin neoplasm of pet rabbits in Europe but is rarely reported in pet rabbits in North America. These neoplasms have not been previously characterized, nor has the cause for the apparent predilection for cutaneous lymphoma in European pet rabbits compared with North American pet rabbits been investigated. In this retrospective study, the authors morphologically and immunohistochemically characterized 25 cutaneous lymphomas in European pet rabbits according to the World Health Organization classification. Tumors were classified as diffuse large B cell lymphomas, with 14 lymphomas exhibiting a centroblastic/centrocytic subtype and 11 tumors exhibiting a T cell-rich B cell subtype. To investigate a potential viral etiology of these lymphomas, 3 diffuse large B cell and 3 T cell-rich B cell lymphomas were evaluated by polymerase chain reaction for retroviral and herpesviral genes. Neither virus was detected. In contrast to other domestic animals, cutaneous lymphomas in European pet rabbits were highly pleomorphic and frequently contained multinucleated giant cells. Unexpectedly, the second most common subtype was T cell-rich B cell lymphoma, a subtype that is rare in species other than horses. Based on a limited number of samples, there was no support for a viral etiology that would explain the higher incidence of lymphoma in European pet rabbits compared with American pet rabbits. Further investigation into genetic and extrinsic factors associated with the development of these tumors is warranted. PMID:22308233

  1. Multiple Complex Congenital Malformations in a Rabbit Kit (Oryctolagus cuniculi)

    PubMed Central

    Booth, Jennifer L; Peng, Xuwen; Baccon, Jennifer; Cooper, Timothy K

    2013-01-01

    Congenital malformations may occur during early embryogenesis in cases of genetic abnormalities or various environmental factors. Affected subjects most often have only one or 2 abnormalities; subjects rarely have several unrelated congenital defects. Here we describe a case of a stillborn New Zealand white rabbit with multiple complex congenital malformations, including synophthalmia, holoprosencephaly, gastroschisis, and a supernumerary hindlimb, among other anomalies. There was no historical exposure to teratogens or other known environmental causes. Although not confirmed, this case was most likely a rare spontaneous genetic event. PMID:24209970

  2. 78 FR 34151 - Notice of Public Hearing: Norfolk Southern Corporation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... issued a public notice seeking comments from interested parties. See 77 FR 74736 (December 17, 2012... hearing will be conducted at the Moon Township Building, 1000 Beaver Grade Road, Moon Township, PA...

  3. 27 CFR 9.203 - Saddle Rock-Malibu.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Conejo land grant, section 3, T1S/R19W; then (3) Proceed straight east-southeast along the El Conejo land... mile along the El Conejo land grant boundary line to its second intersection with the...

  4. Physical and chemical characteristics of Terrace Reservoir, Conejos County, Colorado, May 1994 through May 1995

    USGS Publications Warehouse

    Stogner, Robert W.; Edelmann, Patrick; Walton-Day, Katherine

    1997-01-01

    Terrace Reservoir receives drainage of low-pH, metal-enriched water from mineralized areas, including the Summitville Mine, within the AlamosaRiver Basin. Drainage from the Summitville Mine has contributed a substantial part of the metal load to Terrace Reservoir. From May 1994 through May 1995, a study was done by the U.S. Geological Survey, in cooperation with the U.S. Environmental Protection Agency, to evaluate the physical and chemical characteristics of Terrace Reservoir.Terrace Reservoir was thermally stratified from about mid-May through August 1994. Thermal stratification was absent from September\\x111994through March 1995. During periods of stratification, underflow of the Alamosa River was predominant, and residence times of the underflow were shortened by 40 to 75\\x11percent of the theoretical residence times for a well-mixed reservoir. Transport and deposition of suspended solids in Terrace Reservoir varied spatially and temporally. Most of the suspended solids were deposited in Terrace Reservoir. The concentration of dissolved oxygen in the reservoir varied little spatially or temporally and generally was within a few tenths of the dissolved-oxygen concentration of the inflow. The pH of water in the reservoir generally ranged from about 4.0 to about 7.0, depending on date, depth, and location. The largest pH values were measured during May. A markeddecrease of about 1.5\\x11pH units occurred at site T5 in the reservoir about mid-June. The pH of the reservoir remained at or below 5.5 from mid-June through November. Dissolved-metal concentrations varied spatially and temporally in response to several factors, which included inflow characteristics, reservoir stratification and mixing, inflow-routing and flow-through patterns, residence times, sedimentation, dissolved oxygen, and pH.Inflow chemistry is the dominant controlling factor of metal chemistry within Terrace Reservoir.During periods of stratification, large vertical variations in metal concentrations occurred. The highest metal concentrations in the reservoir generally were measured in the hypolimnion between June and August. During June, epilimnetic water of the reservoir had pH values greater than 6.0, and metal concentrations were lower than hypolimnetic concentrations. In the hypolimnion, pH values were less than 5.5. The difference between the chemistry of the epilimnion and the hypolimnion was due to differences in flow routing and residence times of water in those respective layers. The dissolved-metal concentrations were larger during July and August than during June.During September, small vertical variations in metalconcentrations occurred, and the dissolved-metal concentrations were nearly equivalent to the average August metal concentrations, indicatingthat the metal concentrations measured during September resulted largely from reservoir mixing.During March, the largest metal concentrationsoccurred in the epilimnion, where pH was about 5.5; in the hypolimnion, where the pH was about 6.0, dissolved-metal concentrations were substantially lower and reflected inflow concentrations.

  5. 78 FR 45495 - Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ..., 2013. Andrea Jones, District Ranger. [FR Doc. 2013-17968 Filed 07/26/2013 at 8:45 a.m.; Publication... habitat structural needs of the local populati on of Canada Lynx, a Threatened species, and their...

  6. Perineal striated muscles: Anatomy, spinal motoneurons, and participation on copulatory behavior in male rabbits (Oryctolagus cuniculus).

    PubMed

    Zempoalteca, R; Lucio, R A; Eguibar, J R

    2008-09-01

    Despite the importance of rabbits in reproductive studies, little information is available on the anatomy and participation of the striated-perineal muscles in male copulatory behavior. In our study, we describe the gross anatomy of two striated-perineal muscles: the ischiocavernosus (ICm) and the bulbospongiosus (BSm). Both muscles have their origin at the ischiadic arc, but the ICm is inserted into the penile crura and the BSm onto the ligamentum suspensorium of the penis. The motoneurons of both muscles were identified using retrograde labeling with horseradish peroxidase coupled to wheat-germ agglutinin. Motoneurons were dispersed in the lower-lumbar and upper-sacral spinal-cord segments, instead of being aggregated in the neuronal nucleus as in other species: the rat, mouse, gerbil, cat, and man. Bilateral dennervation of the ICm or BSm or both in sexually experienced male rabbits did not affect copulatory variables measured at 10, 20, and 30 days after surgery. However, muscular dennervation produced extravaginal ejaculations in 42% of copulatory tests and no ejaculation in 7% of tests, although male pelvic thrusting occurred. These results suggest the participation of the ICm and BSm perineal muscles in penile orientation during copulation but not in seminal emission as described in other mammalian species. PMID:18563835

  7. A Three-Dimensional Reconstructive Study of Pelvic Cavity in the New Zealand Rabbit (Oryctolagus cuniculus)

    PubMed Central

    Eken, Emrullah; Kalaycı, İbrahim

    2014-01-01

    The present study has been performed to reveal biometrical aspects and diameter-related differences in terms of sexes regarding pelvic cavity via three-dimensional (3D) reconstruction by using multidetector computed tomography (MDCT) images of pelvic cavity of the New Zealand rabbit. A total of 16 adult New Zealand rabbits, including 8 males and 8 females, were used in this study. Under anesthesia, the images obtained from MDCT were stacked and overlaid to reconstruct the 3D model of the pelvic cavity using 3D modeling software (Mimics 13.1). Measurements, such as the conjugate, transverse, and vertical diameters of the pelvic cavity, and the pelvic inclination were calculated and analyzed statistically. Biometrical differences of the pelvic diameters in New Zealand rabbits of both sexes were shown clearly. It was concluded that the pelvic diameters revealed by 3D modeling techniques can shed light on medical students who take both anatomy training and gynecological applications. The authors hope that the synchronization of medical approaches may give rise to novel diagnostic and therapeutic developments related to pelvic cavity. PMID:25379534

  8. Molecular Characterization of Enterocytozoon bieneusi in Domestic Rabbits (Oryctolagus cuniculus) in Northeastern China.

    PubMed

    Zhang, Xiao-Xuan; Jiang, Jing; Cai, Ya-Nan; Wang, Chun-Feng; Xu, Peng; Yang, Gui-Lian; Zhao, Quan

    2016-02-01

    A study of 426 rabbits from 3 cities in Jilin province (Changchun City and Jilin City) and Liaoning province (Shenyang City) was conducted between May and June 2015. The overall prevalence of E. bieneusi in rabbits was 0.94% (4/426), with 0% (0/116), 1.72% (3/174), and 0.74% (1/136) in Jilin, Changchun, and Shenyang City, respectively. Only 3 farms (farm 1 and farm 3 in Changchun City, farm 8 in Shenyang City) were PCR-positive for E. bieneusi. Moreover, rabbits of more than 6 months (1.72%) had the highest E. bieneusi prevalence, followed by rabbits of 4-6 months (1.26%), 2-3 months (0.58%), and less than 1 month (0%). Analysis of ITS gene of E. bieneusi suggested that all 4 E. bieneusi isolates were genotype D, and were classified as group 1a. The present results first demonstrated the existence of zoonotic E. bieneusi in domestic rabbits in China. Effective control measures should be implemented to prevent E. bieneusi infection in domestic rabbits, other animals, and humans. PMID:26951984

  9. Molecular Characterization of Enterocytozoon bieneusi in Domestic Rabbits (Oryctolagus cuniculus) in Northeastern China

    PubMed Central

    Zhang, Xiao-Xuan; Jiang, Jing; Cai, Ya-Nan; Wang, Chun-Feng; Xu, Peng; Yang, Gui-Lian; Zhao, Quan

    2016-01-01

    A study of 426 rabbits from 3 cities in Jilin province (Changchun City and Jilin City) and Liaoning province (Shenyang City) was conducted between May and June 2015. The overall prevalence of E. bieneusi in rabbits was 0.94% (4/426), with 0% (0/116), 1.72% (3/174), and 0.74% (1/136) in Jilin, Changchun, and Shenyang City, respectively. Only 3 farms (farm 1 and farm 3 in Changchun City, farm 8 in Shenyang City) were PCR-positive for E. bieneusi. Moreover, rabbits of more than 6 months (1.72%) had the highest E. bieneusi prevalence, followed by rabbits of 4-6 months (1.26%), 2-3 months (0.58%), and less than 1 month (0%). Analysis of ITS gene of E. bieneusi suggested that all 4 E. bieneusi isolates were genotype D, and were classified as group 1a. The present results first demonstrated the existence of zoonotic E. bieneusi in domestic rabbits in China. Effective control measures should be implemented to prevent E. bieneusi infection in domestic rabbits, other animals, and humans. PMID:26951984

  10. Timing and Cue Competition in Conditioning of the Nictitating Membrane Response of the Rabbit ("Oryctolagus Cuniculus")

    ERIC Educational Resources Information Center

    Kehoe, E. James; Ludvig, Elliot A.; Sutton, Richard S.

    2013-01-01

    Rabbits were classically conditioned using compounds of tone and light conditioned stimuli (CSs) presented with either simultaneous onsets (Experiment 1) or serial onsets (Experiment 2) in a delay conditioning paradigm. Training with the simultaneous compound reduced the likelihood of a conditioned response (CR) to the individual CSs ("mutual…

  11. Control of Tick Infestations in Oryctolagus cuniculus (Lagomorpha: Leporidae) With Spinosad Under Laboratory and Field Conditions.

    PubMed

    ValcÁrcel, Félix; SÁnchez, J L Pérez; Jaime, J M Tercero; Basco-Basco, P I; Guajardo, S C Cota; Cutuli, M T; GonzÁlez, J; Olmeda, A S

    2015-03-01

    Because of great economic loss in the world's livestock industry, and the serious risks to human health, the control of ticks and tick-borne diseases is one of the most important health management issues today. Current methodology involves integrated tick control for preventing the development of resistance. Rabbits are hosts for immature stages of the three-host tick Hyalomma lusitanicum Koch; so, we focus on this host as a strategy to interrupt the tick life cycle. Spinosad is an insecticide-acaricide, produced by the fermentation of metabolites of the actinomycete bacterium Saccharopolyspora spinosa. We administered spinosad orally by force-feeding naturally and artificially infested rabbits, and under field conditions by administering treated food via a hopper during the period of peak infestation and reinfestation risk for rabbits. No living larvae were recovered from treated laboratory rabbits. In naturally infested rabbits, the number of live ticks collected from treated rabbits (mean = 0.62 ticks per ear) was significantly lower than those recovered from untreated rabbits (mean = 7.27; P < 0.001), whereas the number of dead ticks collected from untreated rabbits (mean = 6.53) was significantly lower than those recovered from treated rabbits (mean = 18.62; P < 0.001). In addition, free and continually reinfested rabbits freely ingested low doses of spinosad, reducing the tick burden from 48.00 (Day 0) to 26.09 ticks per ear in treated rabbits (Day 16), whereas controls maintained the infection (46.64). This strategy could be useful as an alternative or supplement to traditional acaricides in tick control programs. PMID:26336305

  12. Genetics of a tissue esterase polymorphism (Est-6) in the rabbit (Oryctolagus cuniculus).

    PubMed

    van Zutphen, L F; den Bieman, M G; von Deimling, O; Fox, R R

    1987-06-01

    Genetic analysis of a polymorphic tissue esterase revealed a new locus (Est-6) with two alleles (Est-6a and Est-6b) on linkage group VI of the rabbit. Est-6 is closely linked to the Est-1,2,4 cluster. Esterase of Est-6 is found in many organs, particularly in liver and small intestine, but not in erythrocytes and serum. Est-6 esterase hydrolyzes alpha-naphthyl acetate and butyrate, naphthol AS-D acetate, indoxyl acetate, and butyrate as well as 5-bromoindoxyl acetate, N-acetyl-L-alanine-alpha-naphthyl ester but not 4-methylumbelliferyl acetate and fluorescein diacetate. The enzyme is inhibited by bis-p-nitrophenyl phosphate and eserine but not by p-chloromercuribenzoate. It was classified as a carboxylesterase (EC 3.1.1.1). Based on chromosomal localization, tissue distribution, substrate specificity, inhibitor sensitivity, and range of pI's, rabbit Est-6 is assumed to be homologous with mouse Es-7. PMID:3619880

  13. [Peripheral keratinizing ameloblastoma in a dwarf rabbit (Oryctolagus cuniculus f. dom.)].

    PubMed

    Völker, I; Kammeyer, P; Hinzmann, B; Lüerssen, D; Baumgärtner, W; Wohlsein, P

    2014-01-01

    A 3.5-year-old, male, neutered dwarf rabbit was presented with a history of a fast-growing gingival mass at the maxilla. The neoplasm was surgically completely excised. Histopathologically, an expansively growing, multilobulated, partially cystic, peripheral, keratinizing ameloblastoma was diagnosed. The immunohistochemical phenotyping of the tumour cells resulted in cytoplasmic labelling with various pan-cytokeratin antibodies. The cytokeratins 5/6, 7, 10 and 14 were expressed variably. Cytokeratin 20 was not detected. Vimentin was expressed in the cytoplasm of mesenchymal cells of the tumour stroma. In addition, in the nuclei of approximately 10% of the tumour cells the protein of the tumour suppressor gene p53 was expressed while in approximately 5% the proliferation marker Ki67 was expressed. Odontogenic tumours should be considered as a differential diagnosis of oral masses in rabbits. PMID:25323216

  14. Classification and Epidemiology of Mammary Tumours in Pet Rabbits (Oryctolagus cuniculus).

    PubMed

    Baum, B; Hewicker-Trautwein, M

    2015-05-01

    Mammary tumours are common in pet rabbits; however, published studies are predominantly derived from laboratory and meat rabbits. This study reports basic data on type and location of 119 separate tumours from 109 pet rabbits. The animals were aged 2-14 years (mean 5.5 years) and all 90 rabbits of known gender were female. Cranial and caudal mammary glands were affected equally. The majority of lesions (n = 105) were classified as carcinomas with 32 tubular, 16 papillary, 12 tubulopapillary, 11 solid, nine adenosquamous, nine comedo type, five complex, four ductal, three cribriform, three anaplastic and one spindle -cell carcinoma. Twelve percent of the lesions were benign, with eight intraductal papillary adenomas, three simple tubular adenomas and one complex adenoma. One non-neoplastic lesion was found in the form of cystic duct ectasia. PMID:25840882

  15. Seroprevalence and Risk Factors of Chlamydia Infection in Domestic Rabbits (Oryctolagus cuniculus) in China

    PubMed Central

    Ni, Xiaoting; Qin, Siyuan; Lou, Zhilong; Ning, Hongrui; Sun, Xiaolin

    2015-01-01

    Chlamydia spp. are obligate intracellular bacteria distributed all over the world, known to cause various forms of diseases in animals and humans. In the present study, a serological survey was conducted to detect the seroprevalence and risk factors associated with rabbit chlamydiosis in northeast China, including Liaoning province, Jilin province, Heilongjiang province, and Inner Mongolia Autonomous Region. Antibodies to Chlamydia were determined by indirect hemagglutination assay (IHA). The overall seroprevalence was estimated at 17.88% in total of 800 blood samples. The Chlamydia seroprevalence varied in domestic rabbits from different factors, and genders of domestic rabbits were considered as major risk factors associated with Chlamydia infection. Our study revealed a widespread and high prevalence of Chlamydia infection in domestic rabbits in northeast China, with higher exposure risk in female domestic rabbits. These findings suggested the potential importance of domestic rabbits in the transmission of zoonotic Chlamydia infection, and thus Chlamydia should be taken into consideration in diagnosing rabbit diseases. To our knowledge, there is no report of Chlamydia infection in domestic rabbits in China and the results extend the host range for Chlamydia, which has important implications for public health and the local economy. PMID:25945336

  16. An Incidence of Pseudopregnancy Associated with the Social Enrichment of Rabbits (Oryctolagus cuniculi)

    PubMed Central

    Carter, Christopher L; Adams, Joleen K; Czarra, Jane A; Coan, Patricia N

    2016-01-01

    Here we describe a case of pseudopregnancy in a New Zealand White rabbit as a result of pair housing with an aggressive conspecific. Clinical signs included fur pulling and nest building that developed shortly after separation from the aggressor. An ovariohysterectomy was performed, and histopathologic findings support the diagnosis of pseudopregnancy. When introducing adult female rabbits to pair housing, stable pairs may be difficult to achieve because of the dominance-associated behavior that can occur as hierarchal relationships are formed. Does that are pair-housed after puberty should be monitored for aggressive behavior. PMID:26817987

  17. 78 FR 21006 - Consolidated Rail Corporation, CSX Transportation, Inc., and Norfolk Southern Railway Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... this condition adequately protects affected employees, a petition for partial revocation under 49 U.S.C. 10502(d) must be filed. Provided no formal expression of intent to file an offer of financial...

  18. 77 FR 55898 - Norfolk Southern Railway Company-Abandonment Exemption-in Beaufort County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... affected employees, a petition for partial revocation under 49 U.S.C. 10502(d) must be filed. ] Provided no formal expression of intent to file an offer of financial assistance (OFA) has been received,...

  19. 75 FR 34530 - Nittany & Bald Eagle Railroad Company-Temporary Trackage Rights Exemption-Norfolk Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Nittany & Bald Eagle Railroad Company--Temporary Trackage Rights Exemption... rights to Nittany & Bald Eagle Railroad Company (N&BE), between Lock Haven and Driftwood, Pa.,...

  20. 76 FR 24084 - Nittany & Bald Eagle Railroad Company-Temporary Trackage Rights Exemption-Norfolk Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Nittany & Bald Eagle Railroad Company--Temporary Trackage Rights Exemption... rights to Nittany & Bald Eagle Railroad Company (N&BE) over a portion of NSR's line of railroad...

  1. 77 FR 18881 - Nittany & Bald Eagle Railroad Company-Temporary Trackage Rights Exemption-Norfolk Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Nittany & Bald Eagle Railroad Company--Temporary Trackage Rights Exemption... rights to Nittany & Bald Eagle Railroad Company (N&BE), between Lock Haven, Pa. (milepost BR 194.2)...

  2. A Successful Transition from Mini- to Microcomputer-Assisted Instruction: The Norfolk Experience.

    ERIC Educational Resources Information Center

    Gull, Randall L.

    1980-01-01

    Reviews reasons for the decision to change from a timeshare minicomputer to microcomputers, financial considerations involved, the purchase of hardware, the problem posed by the lack of compatible software for the microcomputers, and the development of the Assisted Instructional Development System (AIDS) for adapting minicomputer software and…

  3. 76 FR 56874 - CSX Transportation, Inc.-Trackage Rights Exemption-Norfolk Southern Railway Company, Pennsylvania...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... milepost QAA 10.8 at Jenkin (also known as Jenkintown) and milepost QAA 21.1 at Neshaminy (also known as... follows: (1) Overhead and local trackage rights on the Stony Creek Branch between milepost QAC 3.0 near West Point and milepost QAC 5.0 at Belfrey, (2) overhead trackage rights on the Blue Line Branch...

  4. Influence of pecan-derived biochar on chemical properties of a Norfolk loamy sand soil

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sandy, Coastal Plain soils in the Southeastern USA are low (0.3 to 2%) in soil organic carbon contents (SOC) due to high soil temperatures, abundant rainfall, and a low physico-chemical protection of organic substances. Consequently, the soils have poor soil fertility characteristics. A strategy to ...

  5. Health-Hazard Evaluation Report HETA 85-195-1768, Dale Electronics, Incorporated, Norfolk, Nebraska

    SciTech Connect

    Lee, S.A.

    1987-01-01

    An evaluation was made of exposure to butyl cellosolve, epichlorohydrin, nickel, chromium, antimony, and total particulates for workers in an electronic resistor manufacturing process. No exposure to butyl cellosolve was detected among liquid coaters and no epichlorohydrin was detected in the process area air samples. No exposure to nickel or chromium was detected among mechanical-grinding spirallers. One laser spiraller was exposed to 8 micrograms/m/sup 3/ of nickel and 8 microg/m/sup 3/ chromium. Trace amounts of nickel were noted in the breathing zones of one plating lab worker and one calibrator. Total particulate exposures ranged from 0.1 to 0.9 mg/m/sup 3/. The author concludes that there were no known overexposures to contaminants at this facility and recommends further checking.

  6. Acoustic Modal Patterns and Striations (AMPS) experiment G-325, Norfolk Public Schools

    NASA Technical Reports Server (NTRS)

    Young, Joy W.

    1995-01-01

    This paper will describe how high school students with the guidance of volunteer mentors were able to successfully complete an acoustics space experiment. Some of the NORSTAR program strategies used to effectively accomplish this goal will be discussed. The experiment and present status of results will be explained.

  7. Effects of Polyacrylamide and Organic Matter on Microbes associated to Soil Aggregation of Norfolk Loamy Sand

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Polyacrylamide (PAM, anionic formulation of molecular size 12 MDa and 35% charge density) has been reported to increase aggregation and improve soil physical properties in United States southeastern Coastal Plain loamy sand soils, but nothing is known about the effects of PAM on microbes associated ...

  8. 77 FR 74739 - Norfolk Southern Railway Company-Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... constructed and began operation on a rail line in Roanoke County, Va., which has been an active line since... line. According to NS, operations on its rail line predate the development of the neighborhood. APCO's property is adjacent to the rail line and lies between plaintiffs' properties and NS's rail line....

  9. A Description of the Computer Assisted Assessment Program in University Elementary Algebra at Norfolk State University

    ERIC Educational Resources Information Center

    White, Ronald L.; Myers, Shadana; Earl, Archie W., Sr.

    2008-01-01

    Many colleges and universities today are faced with the problem of low student academic achievement in math. Some of them are trying to improve student academic achievement through the use of technology. Their proposed solution is to teach children how to use the technological tools available to them and integrate that technology into the…

  10. 77 FR 52599 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ..., the Berkley Bridge experienced a seven percent (or 23,560-car) increase in vehicular traffic flow. The... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). 4. Public Meeting We... Register (74 FR 52143) and a notice of proposed rulemaking (NPRM) entitled ``Drawbridge...

  11. 78 FR 17090 - Drawbridge Operation Regulation; Elizabeth River, Eastern Branch, Norfolk, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ..., the Berkley Bridge experienced a seven percent (or 23,560-car) increase in vehicular traffic flow. The... FR Federal Register U.S.C. United States Code VDOT Virginia Department of Transportation VMA Virginia... the Federal Register (77 FR 52599). We received 545 comments on the proposed rule. No public...

  12. Proceedings of NECC/2 National Educational Computing Conference 1980 (Norfolk, Virginia, June 23-25, 1980).

    ERIC Educational Resources Information Center

    Harris, Diana, Ed.; Collison, Beth, Ed.

    This proceedings, which includes 52 papers and abstracts of 13 invited and nine tutorial sessions, provides an overview of the current status of computer usage in education and offers substantive forecasts for academic computing. Papers are presented under the following headings: Business--Economics, Tools and Techniques for Instruction, Computers…

  13. GOES Satellite Data Validation Via Hand-held 4 LED Sun Photometer at Norfolk State University

    NASA Technical Reports Server (NTRS)

    Reynolds, Arthur, Jr.; Jackson, Tyrone; Reynolds, Kevin; Davidson, Cassy; Coope-Pabis, Barbara

    2005-01-01

    Sun photometry is a passive means of measuring a quantity of light radiation. The GIFTS- IOMI/GLOBE Water Vapor/Haze Sun photometer contains four light emitting diodes (LEDs), which are used to convert photocurrent to voltage. The intensity of the incoming and outgoing radiation as detected on the Earth s surface can be affected by aerosols and gases in the atmosphere. The focus of this research is primarily on aerosol and water vapor particles that absorb and reemit energy. Two LEDs in the photometer correspond to light scattered at 530 nm (green spectrum) and 620 nm (red spectrum). They collect data pertaining to aerosols that scatter light. The other two LEDs detect the light scattered by water vapor at wavelengths of 820 nm and 920 nm. The water vapor measurements will be compared to data collected by the Geostationary Observation Environmental Satellite (GOES). Before a comparison can be made, the extraterrestrial constant (ET), which is intrinsic to each sun photometer, must be measured. This paper will present determination of the ET constant, from which the aerosol optical thickness (AOT) can be computed for comparison to the GOES satellite to ascertain the reliability of the sun photometer.

  14. Nanostructured materials for multifunctional applications under NSF-CREST research at Norfolk State University

    NASA Astrophysics Data System (ADS)

    Pradhan, A. K.; Mundle, R.; Zhang, K.; Holloway, T.; Amponsah, O.; Biswal, D.; Konda, R.; White, C.; Dondapati, H.; Santiago, K.; Birdsong, T.; Arslan, M.; Peeples, B.; Shaw, D.; Smak, J.; Samataray, C.; Bahoura, M.

    2012-04-01

    Magnetic nanoparticles of CoFe2O4 have been synthesized under an applied magnetic field through a co-precipitation method followed by thermal treatments at different temperatures, producing nanoparticles of varying size. The magnetic behavior of these nanoparticles of varying size was investigated. As-grown nanoparticles demonstrate superparamagnetism above the blocking temperature, which is dependent on the particle size. The anomalous magnetic behavior is attributed to the preferred Co ions and vacancies arrangements when the CoFe2O4 nanoparticles were synthesized under applied magnetic field. Furthermore, this magnetic property is strongly dependent on the high temperature heat treatments, which produce Co ions and vacancies disorder. We performed the fabrication of condensed and mesoporous silica coated CoFe2O4 magnetic nanocomposites. The CoFe2O4 magnetic nanoparticles were encapsulated with well-defined silica layer. The mesopores in the shell were fabricated as a consequence of removal of organic group of the precursor through annealing. The NiO nanoparticles were loaded into the mesoporous silica. The mesoporous silica coated magnetic nanostructure loaded with NiO as a final product may have potential use in the field of biomedical applications. Growth mechanism of ZnO nanorod arrays on ZnO seed layer investigated by electric and Kelvin probe force microscopy. Both electric and Kelvin force probe microscopy was used to investigate the surface potentials on the ZnO seed layer, which shows a remarkable dependence on the annealing temperature. The optimum temperature for the growth of nanorod arrays normal to the surface was found to be at 600 °C, which is in the range of right surface potentials and energy measured between 500 °C and 700 °C. We demonstrated from both EFM and Kelvin force probe microscopy studies that surface potential controls the growth of ZnO nanorods. This study will provide important understanding of growth of other nanostructures. ZnO nanolayers were also grown by atomic layer deposition techniques. These nanolayers of ZnO demonstrate remarkable optical and electrical properties. These nanolayers were patterned by the Electron Beam Lithography (EBL) technique. A major goal of nanotechnology is to couple the self-assembly of molecular nanostructures with conventional lithography, using either or both bottom-up and top-down fabrication methods, that would enable us to register individual molecular nanostructures onto the functional devices. However, combining the nanofabrication technique with high resolution Electron Beam Lithography, we can achieve 3D bimolecular or/and DNA origami that will be able to identify nucleic acid sequences, antigen targets, and other molecules, as for a perfect nano-biosensor. We have explored some of the nanopatterning using EBL in order to fabricate biomolecule sensing on a single chip with sub nm pitch. The applications are not limited for the bioactivity, but for enhancing immunoreactions, cell culture dishes, and tissue engineering applications.

  15. 78 FR 49603 - Norfolk Southern Railway Company-Abandonment Exemption-in Marengo County, Ala

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... 241.3 N (east of the line's crossing of the mouth of Devil's Run Slough where the slough joins the... railroad bridge over the mouth of Devil's Run Slough at the request of the United States Coast Guard...

  16. Artificial recharge to a freshwater-sensitive brackish-water sand aquifer, Norfolk, Virginia

    USGS Publications Warehouse

    Brown, Donald L.; Silvey, William Dudley

    1977-01-01

    Fresh water was injected into a brackish-water sand for storage and retrieval. The initial injection rate of 400 gpm decreased to 70 gpm during test 3. The specific capacity of the well decreased also, from 15.4 to 0.93 gpm. Current-meter surveys indicated uniform reduction in hydraulic conductivity of all contributing zones in the aquifer. Hydraulic and chemical data indicate this was caused by dispersion of the interstitial clay upon introduction of the calcium bicarbonate water into the sodium chloride bearing sand aquifer. The clay dispersion also caused particulate rearrangement and clogging of well screen. A pre-flush of 0.2 N calcium chloride solution injected in front of the fresh water at the start of test 4 stabilized the clay. However, it did not reverse the particulate clogging that permanently reduced permeability and caused sanding during redevelopment. Clogging can be prevented by stabilization of the clay using commercially available trivalent aluminum compounds. Test 1 and test 2 showed that 85 percent of the water injected can be recovered, and the water meets U.S. Public Health Standards. Storage of fresh water in a brackish-water aquifer appears feasible provided proper control measures are used. (Woodard-USGS)

  17. Amino acid geochronology of the type Cromerian of West Runton, Norfolk, UK.

    PubMed

    Penkman, K E H; Preece, R C; Keen, D H; Collins, M J

    2010-12-01

    Aminostratigraphic studies of continental deposits in the UK have hitherto relied almost exclusively on data from the aragonitic shells of non-marine molluscs for dating Pleistocene sequences. This is usually based on the d/l value of a single amino acid, d-alloisoleucine/l-isoleucine (A/I), in the total shell proteins. Two genera of freshwater gastropods (Valvata and Bithynia) are used to explore the value of using multiple amino acids from the intra-crystalline fraction, which should be more protected from the effects of diagenesis than the inter-crystalline component. Results are compared from both the aragonitic shells and opercula composed of calcite, a more stable form of calcium carbonate. In order to put the amino acid data from the West Runton Freshwater Bed into perspective, statistical analyses are used to compare them with results from the Hoxnian (MIS 11) site at Clacton-on-Sea, Essex. Twelve protein decomposition indicators revealed that the results from the shells were not as clear-cut as those from the opercula. Five indicators from the Valvata shell suggest that West Runton is older than Clacton (at a 95% significance level), but two actually suggested a younger age. Seven indicators show that the Bithynia shells from West Runton are older than congeneric shells from Clacton. In marked contrast, all 12 indicators isolated from the opercula demonstrate that West Runton is significantly older than Clacton. The data are also compared with results from Waverley Wood, an important archaeological site in the English Midlands falling within the 'Cromerian Complex'. Contrary to earlier interpretations, the new amino acid data from Bithynia opercula indicate that West Runton is older than Waverley Wood, a relationship now consistent with the available biostratigraphy. PMID:21217810

  18. Physical and chemical characteristics of Terrace Reservoir, Conejos County, Colorado, May 1994 through May 1995; interim report

    USGS Publications Warehouse

    Stogner, Robert W.; Edelmann, Patrick; Walton-Day, Katherine

    1996-01-01

    Terrace Reservoir receives drainage of low-pH, metal-enriched water from mineralized areas, including the Summitville Mine, within the AlamosaRiver Basin. Drainage from the Summitville Mine has contributed a substantial part of the metal load to Terrace Reservoir. From May 1994 through May 1995, a study was done by the U.S. Geological Survey, in cooperation with the U.S. Environmental Protection Agency, to evaluate the physical and chemical characteristics of Terrace Reservoir.Terrace Reservoir was thermally stratified from about mid-May through August 1994. Thermal stratification was absent from September\\x111994through March 1995. During periods of stratification, underflow of the Alamosa River was predominant, and residence times of the underflow were shortened by 40 to 75\\x11percent of the theoretical residence times for a well-mixed reservoir. Transport and deposition of suspended solids in Terrace Reservoir varied spatially and temporally. Most of the suspended solids were deposited in Terrace Reservoir. The concentration of dissolved oxygen in the reservoir varied little spatially or temporally and generally was within a few tenths of the dissolved-oxygen concentration of the inflow. The pH of water in the reservoir generally ranged from about 4.0 to about 7.0, depending on date, depth, and location. The largest pH values were measured during May. A markeddecrease of about 1.5\\x11pH units occurred at site T5 in the reservoir about mid-June. The pH of the reservoir remained at or below 5.5 from mid-June through November. Dissolved-metal concentrations varied spatially and temporally in response to several factors, which included inflow characteristics, reservoir stratification and mixing, inflow-routing and flow-through patterns, residence times, sedimentation, dissolved oxygen, and pH.Inflow chemistry is the dominant controlling factor of metal chemistry within Terrace Reservoir.During periods of stratification, large vertical variations in metal concentrations occurred. The highest metal concentrations in the reservoir generally were measured in the hypolimnion between June and August. During June, epilimnetic water of the reservoir had pH values greater than 6.0, and metal concentrations were lower than hypolimnetic concentrations. In the hypolimnion, pH values were less than 5.5. The difference between the chemistry of the epilimnion and the hypolimnion was due to differences in flow routing and residence times of water in those respective layers. The dissolved-metal concentrations were larger during July and August than during June.During September, small vertical variations in metalconcentrations occurred, and the dissolved-metal concentrations were nearly equivalent to the average August metal concentrations, indicatingthat the metal concentrations measured during September resulted largely from reservoir mixing.During March, the largest metal concentrationsoccurred in the epilimnion, where pH was about 5.5; in the hypolimnion, where the pH was about 6.0, dissolved-metal concentrations were substantially lower and reflected inflow concentrations.

  19. Assessment of metal transport into and out of Terrace Reservoir, Conejos County, Colorado, April 1994 through March 1995; interim report

    USGS Publications Warehouse

    Ferguson, Sheryl; Edelmann, Patrick

    1996-01-01

    Terrace Reservoir is the primary source of water for crops and livestock in the southwestern part of the San Luis Valley in southern Colorado. Mining activities have occurred in the basin for more than 100 years, and substantial mining of gold has occurred intermittently at the Summitville Mine.Historically, the Summitville Mine site has produced highly acidic, metal-enriched water that drained from the mine site into Wightman Fork and flowed to the Alamosa River and Terrace Reservoir. In 1994, a study was begun as part of risk-assessment and remediation efforts and to evaluate metal transport into and out of Terrace Reservoir. During the study period, the pH immediately upstream from Terrace Reservoir ranged from 4.3 to 7.8. The highest pH occurred during the pre-peak snowmelt period; the lowest pH occurred during storm runoff during summer. Downstream from Terrace Reservoir, the pH ranged from 4.6 to 7.6. The highest pH occurred during the pre-peak snowmelt period, and the lowest pH occurred during summer in mid-July. A comparison of the streamflow hydrographs upstream and downstream from Terrace Reservoir indicated that there was only a small difference between the annual volume of water that entered the reservoir and the annual volume of water that was released from the reservoir. Large spatial and temporal variations in concentrations of the metals of concern occurred during the study.The median and maximum concentrations of dissolved and total aluminum, iron, copper, cadmium, manganese, and zinc were larger upstream from the reservoir than downstream from the reservoir. The largest concentrations of dissolved aluminum, iron, copper, cadmium, manganese, and zinc generally occurred between mid-June and November. Throughout the study, aluminum was transported into the reservoir predominantly in the particulate or suspended form. Downstream from the reservoir, the suspended-aluminum fraction was predominant only during the pre-peak snowmelt and peak snowmelt periods. The temporal variations in the percentage of dissolved and suspended fraction of iron and copper downstream from Terrace Reservoir were similar to the temporal variations that occurred upstream from the reservoir. During the study period, cadmium, manganese, and zinc generally were transported into and out of the reservoir predominantly in the dissolved form. Metal loads varied considerably as a result of changes in streamflow or changes in metal concentrations, or both. The largest daily loads of aluminum, iron, and manganese were transported into and out of Terrace Reservoir during the peak snowmelt period.The reservoir was a sink for an estimated 294 tons of aluminum and 596 tons of iron. However, about 68.5 tons of total aluminum and about 194 tons of total iron were transported out of the reservoir during the study period. During the study period, about 22\\x11tons of total copper remained in the reservoir, and 39 tons was transported downstream from the reservoir. About 47 tons of total manganese and 18 tons of total-zinc loads were transported out of the reservoir; the reservoir was a sink for only a small fraction of total-manganese and -zinc.

  20. Geologic map of the Ute Mountain 7.5' quadrangle, Taos County, New Mexico, and Conejos and Costilla Counties, Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.

    2014-01-01

    The Ute Mountain 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Ute Mountain has the distinction of being one of the largest intermediate composition eruptive centers of the Taos Plateau, a largely volcanic tableland occupying the southern portion of the San Luis Basin. Ute Mountain rises to an elevation in excess of 3,000 m, nearly 700 m above the basaltic plateau at its base, and is characterized by three distinct phases of Pliocene eruptive activity recorded in the stratigraphy exposed on the flanks of the mountain and in the Rio Grande gorge. Unconformably overlain by largely flat-lying lava flows of Servilleta Basalt, the area surrounding Ute Mountain records a westward thickening of basin-fill volcanic deposits interstratified in the subsurface with Pliocene basin-fill sedimentary deposits derived from older Tertiary and Precambrian sources to the east. Superimposed on this volcanic stratigraphy are alluvial and colluvial deposits derived from the flanks of Ute Mountain and more distally-derived alluvium from the uplifted Sangre de Cristo Mountains to the east, that record a complex temporal and stratigraphic succession of Quaternary basin deposition and erosion. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens. These poorly exposed fault scarps cutting lava flows of Ute Mountain volcano. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2) the relative youth of the deposits has resulted in only modest displacements on most faults, and (3) some of the faults may have significant strike-slip components that do not result in large vertical offsets that are readily apparent in offset of sub-horizontal contacts. Those faults characterized as “certain” either have distinct offset of map units or had slip planes that were directly observed in the field. Lineaments defined from magnetic anomalies form an additional constraint on potential fault locations and are indicated as such on the map sheet.

  1. Increased virulence of Rabbit Haemorrhagic Disease Virus associated with genetic resistance in wild Australian rabbits (Oryctolagus cuniculus)

    PubMed Central

    Elsworth, Peter; Cooke, Brian D.; Kovaliski, John; Sinclair, Ronald; Holmes, Edward C.; Strive, Tanja

    2015-01-01

    The release of myxoma virus (MYXV) and Rabbit Haemorrhagic Disease Virus (RHDV) in Australia with the aim of controlling overabundant rabbits has provided a unique opportunity to study the initial spread and establishment of emerging pathogens, as well as their co-evolution with their mammalian hosts. In contrast to MYXV, which attenuated shortly after its introduction, rapid attenuation of RHDV has not been observed. By studying the change in virulence of recent field isolates at a single field site we show, for the first time, that RHDV virulence has increased through time, likely because of selection to overcome developing genetic resistance in Australian wild rabbits. High virulence also appears to be favoured as rabbit carcasses, rather than diseased animals, are the likely source of mechanical insect transmission. These findings not only help elucidate the co-evolutionary interaction between rabbits and RHDV, but reveal some of the key factors shaping virulence evolution. PMID:25146599

  2. Electrocardiograms corresponding to the development of myocardial infarction in anesthetized WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia.

    PubMed

    Kobayashi, Tsutomu; Ito, Takashi; Yamada, Satoshi; Kuniyoshi, Nobue; Shiomi, Masashi

    2012-10-01

    The aim of this study was to determine whether features indicative of myocardial ischemia occur in the electrocardiograms (ECG) in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits, an animal model for human familial hypercholesterolemia. ECG were recorded in 110 anesthetized WHHLMI rabbits (age, 10 to 39 mo) by using unipolar and bipolar limb leads with or without chest leads. We noted the following electrocardiographic changes: T wave inversion (37.4%), ST segment depression (31.8%), deep Q wave (16.3%), reduced R wave amplitude (7.3%), ST segment elevation (2.7%), and high T wave (1.8%). These ECG changes resembled those in human patients with coronary heart disease. Histopathologic examination revealed that the left ventricular wall showed acute myocardial lesions, including loss of cross-striations, vacuolar degeneration, coagulation necrosis of cardiac myocytes, and edema between myofibrils, in addition to chronic myocardial lesions such as myocardial fibrosis. The coronary arteries that caused these ECG changes were severely stenosed due to atherosclerotic lesions. Ischemic ECG changes corresponded to the locations of the myocardial lesions. Normal ECG waveforms were similar between WHHLMI rabbits and humans, in contrast to the large differences between rabbits and mice or rats. In conclusion, ischemic ECG changes in WHHLMI rabbits reflect the location of myocardial lesions, making this model useful for studying coronary heart disease. PMID:23114045

  3. Development of the Lacrimal Apparatus in the Rabbit (Oryctolagus cuniculus) and Its Potential Role as an Animal Model for Humans

    PubMed Central

    Rehorek, S. J.; Holland, J. R.; Johnson, J. L.; Caprez, J. M.; Cray, J.; Mooney, M. P.; Hillenius, W. J.; Smith, T. D.

    2011-01-01

    Rabbits have been proposed as a model organism for the human lacrimal apparatus (LA), including the nasolacrimal duct (NLD), based principally on comparative studies of adult morphology; however, little is known about its development. The NLD first appears as an incomplete primordium in the subcutaneous region of the primordial eyelid and subsequently elongates to reach the naris. One posterior and three anterior orbital glands are present fetally although one of the anterior glands is soon lost. The NLD follows a tortuous path and passes through a bony canal consisting of lacrimal, maxilla, and maxilloturbinal bones at different regions. Although early developmental similarities exist to haplorhine primates, the narial opening of the NLD resembles strepsirrhines. This distinction, along with the ductal and glandular differences at the orbital end of the NLD, indicates that rabbits may be a poor model for LA drainage in primates, specifically humans. PMID:22567296

  4. Exogenous and endogenous stages of Eimeria perforans naturally infected domestic rabbit (Oryctolagus cuniculus) in Saudi Arabia: Light microscopic study

    PubMed Central

    Al-Quraishy, Saleh

    2011-01-01

    Exogenous and endogenous stages of Eimeria perforans naturally infected rabbits in Saudi Arabia were described. The prevalence of infection was 75%. Oocysts were ovoid to elliptical and measured 16 × 10 μm. The four dizoic sporocysts were ovoid and measured 7 × 5 μm. Endogenous stages were restricted to the duodenum. Meronts, microgamonts, macrogamonts and young oocysts were recorded and described. PMID:23961159

  5. Hormonal and behavioral changes induced by acute and chronic experimental infestation with Psoroptes cuniculi in the domestic rabbit Oryctolagus cuniculus

    PubMed Central

    2013-01-01

    Background Parasitic diseases are important in animal production because they cause high economic losses. Affected animals often exhibit stereotypical behavioral alterations such as anorexia and inactivity, among others. Among the diseases that commonly affect domestic rabbits is mange, which is caused by the mite Psoroptes cuniculi. Therefore, within the context of the host-parasite relationship, it is critical to understand the mechanisms involved in the alteration of host behavior, in order to better utilize sick animal behavior as a strategy for diagnosis and treatment of disease. Methods Rabbits were infested placing mites in the ear conduct. We characterized changes in exploratory behavior and scent marking evoked by acute (1-9 days) and chronic (25-33 days) experimental infestation. Behavior was recorded during ten minutes while the animals were in a 120 cm × 120 cm open field arena divided into 9 squares. Serum cortisol was measured individually using radioimmunoassay kits. Locomotor activity, chinning, rearing and body weight were compared using a Friedman test, the effect of treatment (infested versus non-infested) across time was analyzed using a repeated measures ANOVA, and the Pearson test was used to determine whether chinning and ambulation scores were significantly correlated. Serum cortisol levels and food consumption were analyzed with a Kruskal-Wallis test and body temperature was analyzed with an ANOVA test. Results We observed a significant decrease in rearing behavior as early as two days post-infestation, while chinning and locomotor activity were significantly decreased four days post-infestation. Chronic infestation was associated with decreased food intake, significant weight loss, and a trend toward increased serum cortisol levels, while no changes were observed in body temperature. Conclusions The presence of visible lesions within the ear canal is commonly used to detect mite infestation in rabbits, but this is possible only after chronic infestation. The behaviors described here may be a useful and economic tool in guiding the early diagnosis of parasitic infestation by P. cuniculi, allowing for early treatment and the application of control measures before significant weight loss occurs, thereby avoiding economic losses. PMID:24354923

  6. Molecular characterization of antimicrobial resistance in enterococci and Escherichia coli isolates from European wild rabbit (Oryctolagus cuniculus).

    PubMed

    Silva, Nuno; Igrejas, Gilberto; Figueiredo, Nicholas; Gonçalves, Alexandre; Radhouani, Hajer; Rodrigues, Jorge; Poeta, Patrícia

    2010-09-15

    A total of 44 Escherichia coli and 64 enterococci recovered from 77 intestinal samples of wild European rabbits in Portugal were analyzed for resistance to antimicrobial agents. Resistance in E. coli isolates was observed for ampicillin, tetracycline, sulfamethoxazole/trimethoprim, streptomycin, gentamicin, tobramycin, nalidixic acid, ciprofloxacin and chloramphenicol. None of the E. coli isolates produced extended-spectrum beta-lactamases (ESBLs). The bla(TEM), aadA, aac(3)-II, tet(A) and/or tet(B), and the catA genes were demonstrated in all ampicillin, streptomycin, gentamicin, tetracycline, and chloramphenicol-resistant isolates respectively, and the sul1 and/or sul2 and/or sul3 genes in 4 of 5 sulfamethoxazole/trimethoprim resistant isolates. Of the enterococcal isolates, Enterococcus faecalis was the most prevalent detected species (39 isolates), followed by E. faecium (21 isolates) and E. hirae (4 isolates). More than one-fourth (29.7%) of the isolates were resistant to tetracycline; 20.3% were resistant to erythromycin, 14.1% were resistant to ciprofloxacin and 10.9% were resistant to high-level-kanamycin. Lower level of resistance (<10%) was detected for ampicillin, quinupristin/dalfopristin and high-level-gentamicin, -streptomycin. No vancomycin-resistance was detected in the enterococci isolates. Resistance genes detected included aac(6')-aph(2''), ant(6)-Ia, tet(M) and/or tet(L) in all gentamicin, streptomycin and tetracycline-resistant isolates respectively. The aph(3')-IIIa gene was detected in 6 of 7 kanamycin-resistant isolates, the erm(B) gene in 11 of 13 erythromycin-resistant isolates and the vat(D) gene in the quinupristin/dalfopristin-resistant E. faecium isolate. This survey showed that faecal bacteria such as E. coli and enterococci of wild rabbits could be a reservoir of antimicrobial resistance genes. PMID:20624632

  7. One-trial object recognition memory in the domestic rabbit (Oryctolagus cuniculus) is disrupted by NMDA receptor antagonists.

    PubMed

    Hoffman, Kurt Leroy; Basurto, Enrique

    2013-08-01

    The spontaneous response to novelty is the basis of one-trial object recognition tests for the study of object recognition memory (ORM) in rodents. We describe an object recognition task for the rabbit, based on its natural tendency to scent-mark ("chin") novel objects. The object recognition task comprised a 15min sample phase in which the rabbit was placed into an open field arena containing two similar objects, then removed for a 5-360min delay, and then returned to the same arena that contained one object similar to the original ones ("Familiar") and one that differed from the original ones ("Novel"), for a 15min test phase. Chin-marks directed at each of the objects were registered. Some animals received injections (sc) of saline, ketamine (1mg/kg), or MK-801 (37μg/kg), 5 or 20min before the sample phase. We found that chinning decreased across the sample phase, and that this response showed stimulus specificity, a defining characteristic of habituation: in the test phase, chinning directed at the Novel, but not Familiar, object was increased. Chinning directed preferentially at the novel object, which we interpret as novelty-induced sensitization and the behavioral correlate of ORM, was promoted by tactile/visual and spatial novelty. ORM deficits were induced by pre-treatment with MK-801 and, to a lesser extent, ketamine. Novel object discrimination was not observed after delays longer than 5min. These results suggest that short-term habituation and sensitization, not long-term memory, underlie novel object discrimination in this test paradigm. PMID:23651879

  8. Molecular analysis of the microbiota in hard feces from healthy rabbits (Oryctolagus cuniculus) medicated with long term oral meloxicam

    PubMed Central

    2014-01-01

    Background Analgesia is often indicated in rabbits undergoing surgical procedures or suffering from various painful conditions and the most common adverse effects associated with NSAIDs occur in the gastrointestinal tract (GIT). The objective of this study was to determine the potential effect of long-term (21 days) meloxicam administration on the fecal bacterial microbiota in healthy rabbits. Samples of hard feces were collected from six rabbits treated with meloxicam (1 mg/kg orally once every 24 h) on days 0,6,14 and 21. Next generation sequencing of V4 16S rRNA gene products was performed. Results A total of 2589912 V4 rRNA gene sequences passed all quality control filters. Firmicutes predominated (82.0 ± 6.2%). Sixteen other phyla were also identified but other than Verrucomicrobia (4.4 ± 4.9%), all accounted for less than 1% of the identified sequences. Within Firmicutes, Clostridia was the dominant class, accounting for 76% of operational taxon units (OTUs). In general, there were only few differences observed between time points and different rabbits at the phylum level. A significant change was observed in the relative abundance of Proteobacteria over the 4 time points (P = 0.02). Conclusions The gastrointestinal tract of rabbits harbors dense and diverse microbiota. Significant alteration of the hard fecal microbiota does not appear to be a considerable adverse effect expected in rabbits treated for 21 days with oral meloxicam at a dose of 1 mg/kg. PMID:24618207

  9. Timing in Trace Conditioning of the Nictitating Membrane Response of the Rabbit ("Oryctolagus Cuniculus"): Scalar, Nonscalar, and Adaptive Features

    ERIC Educational Resources Information Center

    Kehoe, E. James; Ludvig, Elliot A.; Sutton, Richard S.

    2010-01-01

    Using interstimulus intervals (ISIs) of 125, 250, and 500 msec in trace conditioning of the rabbit nictitating membrane response, the offset times and durations of conditioned responses (CRs) were collected along with onset and peak latencies. All measures were proportional to the ISI, but only onset and peak latencies conformed to the criterion…

  10. Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus).

    PubMed

    Mentré, V; Bulliot, C; Linsart, A; Ronot, P

    2014-06-28

    The purpose of this study was to establish reference intervals for prothrombin time (PT) and activated partial prothrombin time (aPTT) in healthy rabbits using two different point-of-care analysers (Idexx Coag DX and MS Quick Vet Coag Combo). These intervals would be useful in the diagnosis of coagulopathies and in the determination of coagulation status in critical patients. We are unaware of reports of coagulation values in pet rabbits. Blood samples were analysed from 81 clinically healthy pet rabbits under three years of age (49 females and 32 males). The reference intervals were as follows (non-parametric method for the MS Quick Vet Coag Combo and Box-Cox Robust method for the Idexx Coag DX, p<0.05 limit for statistical significance): PT (MS Quick Vet Coag Combo)=N=33, 17.2-28.5; PT (Idexx Coag DX)=N=48, 10.0-14.8, aPTT (MS Quick Vet Coag Combo)=N=33, 103.2-159.2 and aPTT (Idexx Coag DX)=N=48, 104.2-159.1. PT was significantly longer using the MS Quick Vet Coag Combo. aPTT was significantly shorter with the MS Quick Vet Coag Combo. On each type of analyser, there was no significant difference between sexes and blood sampling sites. A significant difference was present for the use or not of anaesthesia with the MS Quick Vet Coag Combo analyser. This study on healthy pet rabbits will be useful in point-of-care diagnosis of coagulopathies. PMID:24722233

  11. 78 FR 16913 - Norfolk Southern Railway Company-Temporary Trackage Rights Exemption-Grand Trunk Western Railroad...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... ] trackage rights to expire 24 months after the commencement date of the agreement, or the date that the Gary City Track Connection, which is located at or near Gary, Ind., is completed and in use, whichever comes...; and (2) between milepost 36.1 in Griffith and CN's Kirk Yard at or near milepost 45.4 in Gary on...

  12. 78 FR 60375 - Norfolk Southern Railway Company-Discontinuance of Service Exemption-in Claiborne County, TN, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... adequately protects affected employees, a petition for partial revocation under 49 U.S.C. 10502(d) must be filed. Provided no formal expression of intent to file an offer of financial assistance (OFA)...

  13. 78 FR 67215 - Norfolk Southern Railway Company-Abandonment Exemption-in Fayette and Wayne Counties, Ind.; C&NC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... protects affected employees, a petition for partial revocation under 49 U.S.C. 10502(d) must be filed. Provided no formal expression of intent to file an offer of financial assistance (OFA) has been...

  14. Symposium on Parallel Computational Methods for Large-scale Structural Analysis and Design, 2nd, Norfolk, VA, US

    NASA Technical Reports Server (NTRS)

    Storaasli, Olaf O. (Editor); Housner, Jerrold M. (Editor)

    1993-01-01

    Computing speed is leaping forward by several orders of magnitude each decade. Engineers and scientists gathered at a NASA Langley symposium to discuss these exciting trends as they apply to parallel computational methods for large-scale structural analysis and design. Among the topics discussed were: large-scale static analysis; dynamic, transient, and thermal analysis; domain decomposition (substructuring); and nonlinear and numerical methods.

  15. Geothermal energy development in the eastern United States geothermal space heating - Naval Air Rework Facility, Norfolk, Virginia

    NASA Astrophysics Data System (ADS)

    Hill, F. K.; Henderson, R. W.

    1980-06-01

    The technical and economic feasibility of using geothermal energy for space heating the Naval Air Rework Facility (NARF) electronic integration hangar was evaluated. The warm water output from a single well was used in several modes: to heat via a floor radiation system or via heat pumps, with and without a ground water reservoir to store heat in off hours.

  16. 78 FR 18677 - Nittany and Bald Eagle Railroad Company-Temporary Trackage Rights Exemption-Norfolk Southern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Nittany and Bald Eagle Railroad Company--Temporary Trackage Rights Exemption... Nittany and Bald Eagle Railroad Company (N&BE) over NS's line of railroad between milepost BR 194.2,...

  17. Understanding 2H/1H systematics of leaf wax n-alkanes in coastal plants at Stiffkey saltmarsh, Norfolk, UK

    NASA Astrophysics Data System (ADS)

    Eley, Yvette; Dawson, Lorna; Black, Stuart; Andrews, Julian; Pedentchouk, Nikolai

    2014-03-01

    Interpretation of sedimentary n-alkyl lipid δ2H data is complicated by a limited understanding of factors controlling interspecies variation in biomarker 2H/1H composition. To distinguish between the effects of interrelated environmental, physical and biochemical controls on the hydrogen isotope composition of n-alkyl lipids, we conducted linked δ2H analyses of soil water, xylem water, leaf water and n-alkanes from a range of C3 and C4 plants growing at a UK saltmarsh (i) across multiple sampling sites, (ii) throughout the 2012 growing season, and (iii) at different times of the day. Soil waters varied isotopically by up to 35‰ depending on marsh sub-environment, and exhibited site-specific seasonal shifts in δ2H up to a maximum of 31‰. Maximum interspecies variation in xylem water was 38‰, while leaf waters differed seasonally by a maximum of 29‰. Leaf wax n-alkane 2H/1H, however, consistently varied by over 100‰ throughout the 2012 growing season, resulting in an interspecies range in the ɛwax/leaf water values of -79‰ to -227‰. From the discrepancy in the magnitude of these isotopic differences, we conclude that mechanisms driving variation in the 2H/1H composition of leaf water, including (i) spatial changes in soil water 2H/1H, (ii) temporal changes in soil water 2H/1H, (iii) differences in xylem water 2H/1H, and (iv) differences in leaf water evaporative 2H-enrichment due to varied plant life forms, cannot explain the range of n-alkane δ2H values we observed. Results from this study suggests that accurate reconstructions of palaeoclimate regimes from sedimentary n-alkane δ2H require further research to constrain those biological mechanisms influencing species-specific differences in 2H/1H fractionation during lipid biosynthesis, in particular where plants have developed biochemical adaptations to water-stressed conditions. Understanding how these mechanisms interact with environmental conditions will be crucial to ensure accurate interpretation of hydrogen isotope signals from the geological record.

  18. Newcomers health in Brantford and the counties of Brant, Haldimand and Norfolk: perspectives of newcomers and service providers.

    PubMed

    Sethi, Bharati

    2013-10-01

    The Canadian government's plan to support a balanced distribution of immigrants throughout the nation has contributed to newcomers' dispersion to small town communities and rural areas. However, very little work has examined the health experiences of immigrants settling in smaller urban and rural regions. Even less literature exists on the perspectives of service providers working with newcomers in Canada's urban-rural communities. This paper focuses on a part of a larger Community-based study on 'Newcomer Settlement and Integration in Education, Training, Employment, Health and Social Support' in Brantford--a middle-sized urban/rural region in Ontario, Canada--and discusses the findings in the health domain. Data were generated from 212 service providers and 237 newcomers using both qualitative and quantitative research tools. Newcomers identified several barriers in accessing mental and/or physical health services including lack of culturally appropriate services and discrimination. The striking differences between newcomers' and service providers' responses to the survey questionnaires bring to light cultural variations between the newcomers' and the service providers' perceptions of 'health'. The findings reinforce the need for including newcomers in developing more inclusive and culturally-appropriate health services and programs. PMID:22773073

  19. Chirp seismic-reflection data from the Baltimore, Washington, and Norfolk Canyons, U.S. mid-Atlantic margin

    USGS Publications Warehouse

    Obelcz, Jeffrey B.; Brothers, Daniel S.; ten Brink, Uri S.; Chaytor, Jason D.; Worley, Charles R.; Moore, Eric M.

    2014-01-01

    A large number of high-resolution geophysical surveys between Cape Hatteras and Georges Bank have been conducted by federal, state, and academic institutions since the turn of the century. A major goal of these surveys is providing a continuous view of bathymetry and shallow stratigraphy at the shelf edge in order to assess levels of geological activity during the current sea level highstand. In 2012, chirp seismic-reflection data was collected by the U.S. Geologial Survey aboard the motor vessel Tiki XIV near three United States mid-Atlantic margin submarine canyons. These data can be used to further our understanding of passive continental margin processes during the Holocene, as well as providing valuable information regarding potential submarine geohazards.

  20. 33 CFR 110.72aa - Elizabeth River Spectator Vessel Anchorage Areas, between Norfolk and Portsmouth, Virginia.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... line drawn between Hospital Point at latitude Latitude 36°50′50.5″ North, longitude 76°18′09.0″ West, and the tip of the channelside pier at the Holiday Inn Marina at latitude 36°50′29.5″ North, longitude... the Elizabeth River, bounded by the shore and a line drawn between Hospital Point at latitude...

  1. 33 CFR 110.72aa - Elizabeth River Spectator Vessel Anchorage Areas, between Norfolk and Portsmouth, Virginia.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... line drawn between Hospital Point at latitude Latitude 36°50′50.5″ North, longitude 76°18′09.0″ West, and the tip of the channelside pier at the Holiday Inn Marina at latitude 36°50′29.5″ North, longitude... the Elizabeth River, bounded by the shore and a line drawn between Hospital Point at latitude...

  2. 33 CFR 110.72aa - Elizabeth River Spectator Vessel Anchorage Areas, between Norfolk and Portsmouth, Virginia.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... line drawn between Hospital Point at latitude Latitude 36°50′50.5″ North, longitude 76°18′09.0″ West, and the tip of the channelside pier at the Holiday Inn Marina at latitude 36°50′29.5″ North, longitude... the Elizabeth River, bounded by the shore and a line drawn between Hospital Point at latitude...

  3. 33 CFR 110.72aa - Elizabeth River Spectator Vessel Anchorage Areas, between Norfolk and Portsmouth, Virginia.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... line drawn between Hospital Point at latitude Latitude 36°50′50.5″ North, longitude 76°18′09.0″ West, and the tip of the channelside pier at the Holiday Inn Marina at latitude 36°50′29.5″ North, longitude... the Elizabeth River, bounded by the shore and a line drawn between Hospital Point at latitude...

  4. 33 CFR 110.72aa - Elizabeth River Spectator Vessel Anchorage Areas, between Norfolk and Portsmouth, Virginia.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... line drawn between Hospital Point at latitude Latitude 36°50′50.5″ North, longitude 76°18′09.0″ West, and the tip of the channelside pier at the Holiday Inn Marina at latitude 36°50′29.5″ North, longitude... the Elizabeth River, bounded by the shore and a line drawn between Hospital Point at latitude...

  5. 77 FR 75016 - Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... around the Gilmerton Bridge center span barge (77 FR 73541). Inadvertently, this rule included an error... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone: Gilmerton Bridge Center Span Float-in... Federal Register an interim temporary final rule establishing a safety zone around the Gilmerton...

  6. 77 FR 73541 - Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Gilmerton Bridge Area (77 FR 43557) on September 5-9, 2012. We received no comments on the proposed rule... CFR Part 165 RIN 1625-AA00 Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River...-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR...

  7. 77 FR 35900 - Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Gilmerton Bridge Center Span Float-in... provide for the safety of life on navigable waters during the Gilmerton Bridge Center Span Float- in and... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of...

  8. 77 FR 22389 - State of Michigan Department of Transportation-Acquisition Exemption-Certain Assets of Norfolk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board State of Michigan Department of Transportation--Acquisition Exemption... milepost 7.60 at Townline in Wayne County, Mich. to approximately milepost 119.60 at CP Baron in...

  9. 78 FR 57682 - Norfolk Southern Railway Company-Discontinuance of Service Exemption-in Monroe County, Mich.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... service over an approximately 1.7-mile line of railroad extending between milepost XV 0.0 and milepost XV 1.7, in Monroe County, Mich. (the Line). The Line traverses United States Postal Service Zip Code 48161. NSR has certified that: (1) No local traffic has moved over the Line for at least two years;...

  10. Toward a Theory of Historically Black College and University (HBCU) Distinctiveness: A Case Study of Norfolk State University

    ERIC Educational Resources Information Center

    Arroyo, Andrew Thomas

    2010-01-01

    Research into Historically Black Colleges and Universities (HBCUs) tends to be repetitive, anecdotal, and derivative. A need exists for new lines of research into these institutions. One way to facilitate this is by using social scientific mechanisms to develop HBCU-specific theoretical models to describe, explain, and predict the full range of…