Sample records for conservation par irradiation

  1. EFFETS DES FAIBLES IRRADIATIONS SUR L'URANIUM Par Y. QUR,

    E-print Network

    Boyer, Edmond

    489. EFFETS DES FAIBLES IRRADIATIONS SUR L'URANIUM Par Y. QUÉRÉ, Centre d'Études Nucléaires de fragments de fission dans l'uranium, on présente quelques résultats de mesure de longueur et de résistivité modifiés. Abstract. 2014 After recalling Brinkman's model for the action of fission fragments on uranium

  2. Breast conservation treatment with perioperative interstitial irradiation

    SciTech Connect

    Krishnan, L.; Mansfield, C.M.; Jewell, W.R.; Reddy, E.K.; Thomas, J.H.; Krishnan, E.C.

    1987-10-01

    Limited resection of the breast combined with radiation has proved to be as effective as more radical surgery in treating early breast cancer. At the University of Kansas Medical Center, the radiotherapy consists of an interstitial implant at the time of lumpectomy to deliver an interstitial boost dose to the tumor bed with iridium-192 immediately following the surgical procedure. An axillary node dissection is also performed at the time of lumpectomy. A dose of 2000 cGy is delivered to the tumor bed between 40 and 60 h. Two to three weeks later, 4500-5000 cGy is delivered to the entire breast with external beam radiation over 5-5.5 weeks. One hundred breasts in 98 patients were so treated between June 1982 and February 1986, with 2 carcinomas in situ, 40 stage I, 51 stage II, and 7 stage III cancers, consisting of 2 TIS, 54 T1, 39 T2, and 5 T3 lesions. Locoregional control with a median follow-up of 31 months was 98%. One recurrence was in a different quadrant, and the other revealed predominantly the in situ component. Immediate implant did not compromise wound healing or cosmesis. The cosmetic result was graded as good to excellent in 88% of the breasts. Our preliminary results appear to suggest a better local control with immediate interstitial irradiation.

  3. Régulation de la production, par des cellules endothéliales, de cytokines pro-inflammatoires après irradiation

    NASA Astrophysics Data System (ADS)

    van der Meeren, A.; Lafont, H.; Mathé, D.

    1998-04-01

    Gamma irradiation leads to an increased production of interleukin- (IL)-6 and IL-8 by human endothelial cells. In order to regulate the radio-induced production of these pro-inflammatory cytokines, we used the immunoregulatory cytokines IL-4 and IL-10. These agents were added either before or after a 10 Gy-irradiation. Our results show that it is possible to decrease the radio-induced production of IL-6 and IL-8 with the use of IL-4 and IL-10. Differences in the intensity of the response have been observed according to the time of treatment. The anti-inflammatory potential of both IL-4 and IL-10 was more pronounced when added after irradiation. Après irradiation gamma, des cellules endothéliales humaines ont une production accrue des interleukines (IL-) -6 et -8. Dans le but de réguler la production de ces cytokines pro-inflammatoires, nous avons utilisé des cytokines dites anti-inflammatoires, l'IL-4 et l'IL-10. Ces agents ont été ajoutés soit avant soit après une irradiation de 10Gy. Nos résultats montrent qu'il est possible de diminuer les productions radio-induites d'IL-6 et d'IL-8 par l'IL-4 et l'IL-10. Des différences dans l'intensité de la réponse ont toutefois été observées selon que l'IL-4 ou l'IL-10 ont été ajoutées avant ou après irradiation; leur efficacité anti-inflammatoire étant plus marquée lorsque les cytokines sont ajoutées après l'irradiation.

  4. Perioperative interstitial irradiation in the conservative management of early breast cancer

    SciTech Connect

    Krishnan, L.; Jewell, W.R.; Mansfield, C.M.; Reddy, E.K.; Thomas, J.H.; Krishnan, E.C.

    1987-11-01

    Conservation of the breast in early breast cancer with limited resection and radiation is proving to be as effective as modified radical mastectomy in survival and in loco-regional control. Management at the University of Kansas Medical Center consists of an interstitial implant at the time of lumpectomy to facilitate perioperative irradiation with Iridium-192 to the tumor bed. An axillary node dissection is also performed at that time. Two to 3 weeks later external beam irradiation is delivered to the entire breast. One hundred and twenty-three breasts in 120 patients have been treated between June 1982 and June 1986. There were 49 pathological Stage I, 63 Stage II, 8 Stage III carcinomas, and 3 carcinomas in situ, consisting of 72 T1, 43 T2, 5 T3, and 3 TIS lesions. Patients have been followed for a median of 30 months. One patient had a ''true'' recurrence in the breast. Another patient developed recurrence in a different quadrant. Ninety percent of the patients had good to excellent cosmetic results, 7% were considered fair, and 3% had poor results. Seven patients developed mild arm edema, 4 were found to have moderate edema, and 1 had severe arm edema. Our preliminary results indicate that interstitial irradiation immediately after excision results in excellent local control, with very satisfactory cosmesis and no morbidity due to the simultaneous excision and irradiation.

  5. Endommagement produit dans des films de fer ? irradies a 77 K par different ions

    NASA Astrophysics Data System (ADS)

    Jaouen, C.; Riviere, J. P.; Fayoux, C.; Dinhut, J. F.; Delafond, J.

    1983-05-01

    Radiation damage in pure Fe is studied at 77 K during bombardment with ions of increasing energy and atomic mass, i.e. B, Ar, Fe, Xe. The film thickness and the beam energy are selected such that a central damaged layer of comparable relative width for the different incident ions is produced in the samples. The electrical resistivity variations of the specimens are continuously measured as a function of the ion fluence and interpreted in terms of defect production in displacement cascades. The experimental number of stable Frenkel pairs produced per incident ion is determined from the initial damage rates ??0 and compared with the calculated values based on a modified Kinchin-Pease model. It is found that the damage efficiency decreases as a function of the incident ion mass or deposited energy per atom. These results are compared on the one hand with similar studies done in f.c.c. metals (Au, Cu and Ag) and on the other hand with damage rate studies for other types of irradiation in pure Fe.

  6. Mecanismes de deformation de nanoparticules d'Au par irradiation ionique

    NASA Astrophysics Data System (ADS)

    Harkati Kerbouah, Chahineze

    2011-12-01

    In the present thesis, we study the anisotropic deformation of gold nanoparticles embedded in amorphous silica or crystalline aluminum arsenide, under ion bombardment. We try to comprehend the mechanism responsible for this deformation and to remove any ambiguity related to the explanation of this phenomenon. A hybrid process combining sputtering and plasma enhanced chemical vapour deposition was used to fabricate Au/SiO2 layers on fused silica substrates. Structures with single and multilayer were obtained. Heating during or after deposition activates the Au atom agglomeration and favours the growth of the nanoparticles. Also, a Au/AlAs nanocomposite was obtained by ion implantation of AlAs films, followed by rapid thermal annealing. The samples of the two nanocomposites, cooled with liquid nitrogen, were irradiated with 2 to 40 MeV Cu, Si, Au or In ion beams, at fluences ranging from 1x10 13 to 4x1015 ions/cm2, using a Tandem or Tandetron accelerator. The structural and morphological properties of the Au/SiO2 nanocomposite were extracted by optical means; the frequency and the width of surface plasmon resonance band depend on the nanoparticle shape and size, their concentration, the inter-particle distance and the dielectric properties of material in which the particles are embedded. The aluminum arsenide crystallinity was studied by two techniques: Raman spectroscopy and Rutherford backscattering spectrometry in channelling configuration (RBS/ channelling). The Au concentration in the nanocomposite layers was deducted from RBS results. The size distribution and metallic nanoparticles shape transformation in both nanocomposites were observed by electronic transmission microscopy. The results obtained within the framework of this work are the subject of three journal papers. The first publication shows the possibility of manipulating the width and spectral position of the gold nanoparticle absorption band in Au/SiO2 nanocomposites by modifying their structure (form, size and inter-particle distance). The obtained Au nanoparticles are nearly spherical. The surface plasmon (PS) absorption band corresponding to the distant particles is located at 520 nm. After ion irradiation, the spherical nanoparticles transform into ellipsoids aligned along the ion beam. The absorption band splits into two bands: transversal and longitudinal. The band corresponding to the ellipsoids small axis (transversal) is blue-shifted and that corresponding to the long axis (longitudinal) is red-shifted indicating the elongation of particles in the beam direction. The second paper is consecrated to the crucial role of the plastic deformation of the matrix and to the importance of the metal atomic mobility in the anisotropic nanoparticles deformation in Au/SiO 2 nanocomposites. Our measurements show that a threshold value of 2 keV/nm (electronic stopping power) is necessary for the deformation of Au nanoparticles. This value is close to that required for silica deformation. Mobility of the Au atoms at the time of the ion passage is confirmed by temperature calculation within the ionic track. The third paper treats the attempt of formation and deformation of Au nanoparticles in crystalline aluminum arsenide matrix known by its high resistance to amorphisation and deformation under ionic bombardment. The principal result of the last article confirms the essential role of the matrix. It proves that the anisotropic deformation of surrounding material is indispensable for gold nanoparticles deformation. The experimental results mentioned above and temperature calculations within ionic tracks allowed us to propose the following anisotropic deformation scenario of Au nanoparticles embedded in Au/SiO2 nanocomposite: (1) Each ion crossing the silica melts (very briefly) a narrow cylinder around its trajectory forming thus a latent track. This is consistent with the observed threshold value in the electronic stopping power. (2) The cumulative effect of many separate ion impacts leads to the anisotropic growth of the silica matrix which contracts in the direct

  7. Cosmetic outcome 1-5 years after breast conservative surgery, irradiation and systemic therapy.

    PubMed

    Kelemen, Gyöngyi; Varga, Zoltán; Lázár, György; Thurzó, László; Kahán, Zsuzsanna

    2012-04-01

    The late side-effects of the local therapy of early breast cancer depend on many patient- and therapy-related parameters. We aimed at investigating the factors that influence the cosmetic and functional outcomes among our breast cancer patients after breast-conserving surgery and conformal radiotherapy, with or without adjuvant systemic therapy. A study was made of the association of the cosmetic outcome after a median follow-up time of 2.4 years and the clinical data on 198 patients extracted from a prospectively compiled database. Breast tenderness occurred more frequently among patients ?50 years old (p?irradiated breast volume, while that of breast edema and breast fibrosis increased by 21% and 12%, respectively for every 10 cm(3) increase in the boost volume. Patients who received a photon boost were significantly more likely to develop breast edema and fibrosis than those who received electrons (p?irradiated breast (p?=?0.037). Dyspigmentation developed more often among patients older than 50 years, while smoking favoured both dyspigmentation and teleangiectasia. Breast edema was related to dyspigmentation (p?=?0.003), fibrosis (p?conserving surgery and postoperative radiotherapy. PMID:21984131

  8. Validation of a method to estimate direct normal irradiance of UVA and PAR bands from global horizontal measurements for cloudless sky conditions in Valencia, Spain, by a measurement campaign

    NASA Astrophysics Data System (ADS)

    Serrano, María-Antonia; Boscà, José V.

    2011-01-01

    A method is proposed to provide measurement of direct normal solar irradiance of bands with wavelength ranges (315-400 nm, 400-700 nm) from measurements of global horizontal band irradiance for cloudless sky conditions in Valencia. Global and normal direct irradiance data for every air mass were obtained by applying the SMART2 model to the atmosphere of Valencia. The direct normal to global irradiance ratio was parameterized versus the relative optical air mass. A measurement campaign of global horizontal and diffuse irradiance of UVA and PAR bands was carried out in Valencia, after which, the inferred direct normal irradiance was compared with those provided by the method. The result of the comparison shows that the method is acceptably accurate. The proposed model tends to underestimate the direct normal irradiance of the UVA band by 6%, although for values below 25 W/m2 the model overestimates the direct irradiance by 6%, while for values above 25 W/m2 the model underestimates it by 10%. The other two error estimators used ranging from 11% to 15% are similar in the defined interval measurements in relation to the whole UVA band. Regarding the PAR band, the model overestimates the direct normal irradiance of the PAR band by only 2.2%. With this, the results of the PAR band are more conclusive, as it has been found that for direct normal irradiance values higher than 280 W/m2 the MBE error is almost zero and the other two estimator errors are small, about 5%.

  9. Comparison of Electron and X-Ray Beams for Tumor Bed Boost Irradiation in Breast-Conserving Treatment

    PubMed Central

    Park, Shin-Hyung

    2013-01-01

    Purpose This study aimed to compare the dosimetric profiles of electron beams (EB) and X-ray beams (XB) for boosting irradiation in breast cancer patients who underwent breast-conserving surgery and postoperative radiotherapy. Methods For 131 breast cancer patients who underwent breast-conserving surgery, we compared plans for EB and XB boost irradiation after whole-breast irradiation. The organs at risk (OAR) included the cardiac chambers, coronary arteries, ipsilateral lung, and skin. The conformity index (CI), inhomogeneity index (IHI), and dose-volume parameters for the planning target volume (PTV), and OAR were calculated. Postradiotherapy chest computed tomography scans were performed to detect radiation pneumonitis. Results XB plans showed a significantly better CI and IHI for the PTVs, compared to the EB plans. Regarding OAR sparing, the XB reduced the high-dose volume at the expense of an increased low-dose volume. In 33 patients whose radiation fields included nipples, IHI was higher in the EB plans, whereas the presence of a nipple in the radiation field did not interfere with the XB. EB-treated patients developed more subclinical radiation pneumonitis. Conclusion XB plans were superior to EB plans in terms of PTV coverage (homogeneity and conformity) and high-dose volume sparing in OAR when used as boost irradiation after breast-conserving surgery. A disadvantage of the XB plan was an increased low-dose volume in the OAR, but this was offset by the increased electron energy. Consequently, tailored plans with either XB or EB are necessary to adapt to patient anatomic variance and tumor bed geometric properties. PMID:24155759

  10. Conservation.

    ERIC Educational Resources Information Center

    National Audubon Society, New York, NY.

    This set of teaching aids consists of seven Audubon Nature Bulletins, providing the teacher and student with informational reading on various topics in conservation. The bulletins have these titles: Plants as Makers of Soil, Water Pollution Control, The Ground Water Table, Conservation--To Keep This Earth Habitable, Our Threatened Air Supply,…

  11. Conservation surgery and irradiation for the treatment of favorable breast cancer. [Gamma radiation

    Microsoft Academic Search

    E. D. Montague; A. E. Gutierrez; J. L. Barker; N. D. Tapley; G. H. Fletcher

    1979-01-01

    The results in 162 patients with clinically favorable breast cancer treated with conservation surgery and radiation therapy are presented. The surgical procedures were simple excision with and without positive microscopic margins, segmental mastectomy, and segmental mastectomy with axillary dissection. Details of the radiation techniques are described with an explanation of the modifications in technique depending on the prior surgical procedure.

  12. Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Compliance to the Dosimetry Requirements of RTOG-0413

    SciTech Connect

    Wen Bixiu [Department of Radiation Oncology, New York University Medical Center, New York, New York (United States) [Department of Radiation Oncology, New York University Medical Center, New York, New York (United States); Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080 (China); Hsu, Howard; Formenti-Ujlaki, George F.; Lymberis, Stella; Magnolfi, Chiara; Zhao Xuan; Chang Jenghwa; DeWyngaert, J. Keith; Jozsef, Gabor [Department of Radiation Oncology, New York University Medical Center, New York, New York (United States)] [Department of Radiation Oncology, New York University Medical Center, New York, New York (United States); Formenti, Silvia C., E-mail: silvia.formenti@nyumc.org [Department of Radiation Oncology, New York University Medical Center, New York, New York (United States)

    2012-11-15

    Purpose: The dosimetric results from our institution's trials of prone accelerated partial breast irradiation are compared with the dosimetric requirements of RTOG-0413. Methods and Materials: Trial 1 and Trial 2 are 2 consecutive trials of prone-accelerated partial breast irradiation. Eligible for both trials were stage I breast cancer patients with negative margins after breast-conserving surgery. The planning target tumor volume (PTV) was created by extending the surgical cavity 2.0 cm for Trial 1 and 1.5 cm for Trial 2, respectively. Contralateral breast, heart, lungs, and thyroid were contoured. Thirty Gray was delivered in five daily fractions of 6 Gy by a three-dimensional conformal radiation therapy technique in Trial 1 and were by image-guided radiation therapy/intensity-modulated radiation therapy in Trial 2. Dosimetric results from the trials are reported and compared with RTOG 0413 requirements. Results: One hundred forty-six consecutive plans were analyzed: 67 left and 79 right breast cancers. The plans from the trials complied with the required >90% of prescribed dose covering 90% of PTV{sub E}VAL (=generated from the PTV by cropping 0.5 cm from the skin edge and excluding the chest wall): V90% was 98.1 {+-} 3.0% (with V100% and V95%, 89.4 {+-} 12.8%, 96.4 {+-} 5.1%, respectively). No significant difference between laterality was found (Student's t test). The dose constraints criteria of the RTOG-0413 protocol for ipsilateral and contralateral lung (V30 <15% and Dmax <3%), heart (V5 <40%), and thyroid (Dmax <3%) were satisfied because the plans showed an average V5% of 0.6% (range, 0-13.4) for heart, an average V30% of 0.6% (range, 0-9.1%) for ipsilateral lung, and <2% maximum dose to the thyroid. However, our partial breast irradiation plans demonstrated a higher dose to contralateral breast than that defined by RTOG constraints, with a median value of maximum doses of 4.1% (1.2 Gy), possibly as a result of contouring differences. Conclusions: Our technique for prone accelerated partial breast irradiation generally satisfied RTOG-0413 requirements.

  13. Treatment Techniques to Reduce Cardiac Irradiation for Breast Cancer Patients Treated with Breast-Conserving Surgery and Radiation Therapy: A Review

    PubMed Central

    Beck, Robert E.; Kim, Leonard; Yue, Ning J.; Haffty, Bruce G.; Khan, Atif J.; Goyal, Sharad

    2014-01-01

    Thousands of women diagnosed with breast cancer each year receive breast-conserving surgery followed by adjuvant radiation therapy. For women with left-sided breast cancer, there is risk of potential cardiotoxicity from the radiation therapy. As data have become available to quantify the risk of cardiotoxicity from radiation, strategies have also developed to reduce the dose of radiation to the heart without compromising radiation dose to the breast. Several broad categories of techniques to reduce cardiac radiation doses include breath hold techniques, prone positioning, intensity-modulated radiation therapy, and accelerated partial breast irradiation, as well as many small techniques to improve traditional three-dimensional conformal radiation therapy. This review summarizes the published scientific literature on the various techniques to decrease cardiac irradiation in women treated to the left breast for breast cancer after breast-conserving surgery. PMID:25452938

  14. Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

    Microsoft Academic Search

    Atsushi Suzuki; Tomoyuki Yamanaka; Tomonori Hirose; Naoyuki Manabe; Keiko Mizuno; Miki Shimizu; Kazunori Akimoto; Yasushi Izumi; Tetsuo Ohnishi; Shigeo Ohno

    2001-01-01

    We have previously shown that during early Caenorhabditis elegans embryogenesis PKC-3, a C. elegans atypical PKC (aPKC), plays critical roles in the establishment of cell polarity required for subse- quent asymmetric cleavage by interacting with PAR-3 (Tabuse, Y., Y. Izumi, F. Piano, K.J. Kemphues, J. Miwa, and S. Ohno. 1998. Development (Camb.). 125:3607- 3614). Together with the fact that aPKC

  15. Elaborating polarity: PAR proteins and the cytoskeleton

    PubMed Central

    Nance, Jeremy; Zallen, Jennifer A.

    2011-01-01

    Cell polarity is essential for cells to divide asymmetrically, form spatially restricted subcellular structures and participate in three-dimensional multicellular organization. PAR proteins are conserved polarity regulators that function by generating cortical landmarks that establish dynamic asymmetries in the distribution of effector proteins. Here, we review recent findings on the role of PAR proteins in cell polarity in C. elegans and Drosophila, and emphasize the links that exist between PAR networks and cytoskeletal proteins that both regulate PAR protein localization and act as downstream effectors to elaborate polarity within the cell. PMID:21303844

  16. ParB spreading requires DNA bridging

    PubMed Central

    Graham, Thomas G.W.; Wang, Xindan; Song, Dan; Etson, Candice M.; van Oijen, Antoine M.; Rudner, David Z.; Loparo, Joseph J.

    2014-01-01

    The parABS system is a widely employed mechanism for plasmid partitioning and chromosome segregation in bacteria. ParB binds to parS sites on plasmids and chromosomes and associates with broad regions of adjacent DNA, a phenomenon known as spreading. Although essential for ParB function, the mechanism of spreading remains poorly understood. Using single-molecule approaches, we discovered that Bacillus subtilis ParB (Spo0J) is able to trap DNA loops. Point mutants in Spo0J that disrupt DNA bridging are defective in spreading and recruitment of structural maintenance of chromosomes (SMC) condensin complexes in vivo. DNA bridging helps to explain how a limited number of Spo0J molecules per parS site (?20) can spread over many kilobases and suggests a mechanism by which ParB proteins could facilitate the loading of SMC complexes. We show that DNA bridging is a property of diverse ParB homologs, suggesting broad evolutionary conservation. PMID:24829297

  17. A Single parS Sequence from the Cluster of Four Sites Closest to oriC Is Necessary and Sufficient for Proper Chromosome Segregation in Pseudomonas aeruginosa

    PubMed Central

    Jecz, Paulina; Bartosik, Aneta A.; Glabski, Krzysztof; Jagura-Burdzy, Grazyna

    2015-01-01

    Among the mechanisms that control chromosome segregation in bacteria are highly-conserved partitioning systems comprising three components: ParA protein (a deviant Walker-type ATPase), ParB protein (a DNA-binding element) and multiple cis-acting palindromic centromere-like sequences, designated parS. Ten putative parS sites have been identified in the P. aeruginosa PAO1 genome, four localized in close proximity of oriC and six, diverged by more than one nucleotide from a perfect palindromic sequence, dispersed along the chromosome. Here, we constructed and analyzed P. aeruginosa mutants deprived of each single parS sequence and their different combinations. The analysis included evaluation of a set of phenotypic features, chromosome segregation, and ParB localization in the cells. It was found that ParB binds specifically to all ten parS sites, although with different affinities. The P. aeruginosa parS mutant with all ten parS sites modified (parSnull) is viable however it demonstrates the phenotype characteristic for parAnull or parBnull mutants: slightly slower growth rate, high frequency of anucleate cells, and defects in motility. The genomic position and sequence of parS determine its role in P. aeruginosa biology. It transpired that any one of the four parS sites proximal to oriC (parS1 to parS4), which are bound by ParB with the highest affinity, is necessary and sufficient for the parABS role in chromosome partitioning. When all these four sites are mutated simultaneously, the strain shows the parSnull phenotype, which indicates that none of the remaining six parS sites can substitute for these four oriC-proximal sites in this function. A single ectopic parS2 (inserted opposite oriC in the parSnull mutant) facilitates ParB organization into regularly spaced condensed foci and reverses some of the mutant phenotypes but is not sufficient for accurate chromosome segregation. PMID:25794281

  18. The influence of the use of CT-planning on the irradiated boost volume in breast conserving treatment

    Microsoft Academic Search

    Shafak Al Uwini; Ninja Antonini; Philip M. Poortmans; Liesbeth Boersma; Coen Hurkmans; Jan Willem Leer; Jean-Claude Horiot; Henk Struikmans; Harry Bartelink

    2009-01-01

    Background and purposeThe purpose of this study was to investigate the effect of CT-based delineation and planning on the irradiated boost volume. For this specific purpose we used the data as derived from 2 prospective phase III randomised trials.

  19. Excimer laser irradiation at 248 nm of wooden archaeological objects and polymeric consolidants used in conservation: a study of cone formation and optimum cleaning parameters

    NASA Astrophysics Data System (ADS)

    Belli, R.; Toniutti, L.; Miotello, A.; Mosaner, P.; Avi, D.

    2008-07-01

    Samples of a prehistoric consolidated vegetable basketry, coming from an important pile building in the North-East of Italy (Fiavé Carrera, Trento), had been irradiated with excimer laser pulses to remove the consolidant layer and restore the artifact. Some problems, related to the nature of the consolidant resin, were found in the preliminary laser cleaning process. The two main obstacles were related to the unknown composition of the polymeric resin and to the irregular surface morphology of the archaeological find. We observed that large numbers of laser pulses, for selected laser parameters, strongly modify the resin surface morphology with formation of a large number of cones. After cone formation, the surface was so irregular that it was almost impossible to complete the laser cleaning procedure. To find a solution to the problem, we here try to understand the mechanisms of cone formation in the present polymeric material. Scanning electron microscopy (SEM) and Fourier transformation infrared spectroscopy (FTIR) have been used to study surface morphology and chemical modification after selected irradiation processes. To understand the influence of laser irradiation on surface modifications and to establish a cleaning procedure for this specific application, investigations have been carried out separately on models of resin consolidants and wood (both dried and buried wood sample). The consolidants were commercial resins, typically used in archaeological conservation (Plexisol and Paraloid), deposited on a silicon substrate. Silicon was used because it is an appropriate substrate in FT-IR analysis. Finally, we chose wood because of its wide use in prehistoric artefact (Viburnum lantana).

  20. Review of PAR parameterizations in ocean ecosystem models

    NASA Astrophysics Data System (ADS)

    Byun, Do-Seong; Wang, Xiao Hua; Hart, Deirdre E.; Zavatarelli, Marco

    2014-12-01

    Commonly-used empirical equations for calculating downward 'photosynthetically available radiation' or PAR were reviewed in order to identify a more theoretically-sound parameterization for application to ocean biogeochemical models. Three different forms of broadband PAR parameterization are currently employed in biogeochemical models, each of them originating from the downward irradiance formulations normally applied to ocean circulation models, which produce poor attenuation estimates for PAR. Two of the PAR formulations, a single-exponential function and a double-exponential function, are parameterized by multiplying surface irradiance by a coefficient determining the portion of underwater PAR. The third formulation uses the second term of the double-exponential function. After elucidating the theoretical problems of modeling PAR using these parameterizations, we suggest an improved, R-modified double-exponential PAR formulation, including Paulson and Simpson's (1977) parameter values. We also newly estimate PAR penetration via least-squares fitting of values digitized from Jerlov's (1976) observations in different oceanic water types, and compare this PAR-observation derived parameterization with our new, theoretical, R-modified parameterization. Finally, we discuss a universal limitation inherent in current theoretical approaches to PAR parameterization.

  1. Relationships of photosynthetically active radiation and shortwave irradiance

    Microsoft Academic Search

    G. Papaioannou; N. Papanikolaou; D. Retalis

    1993-01-01

    Hourly measurements of solar irradiance in the wave band excluding photosynthetically active radiation (PAR) and solar irradiance (SI) were made over a 12-month period at the National Observatory of Athens, for obtaining the ratios of PAR to SI. These irradiance ratios exhibit dependence on sky conditions, with slightly larger values being observed under “cloudy” skies and seasonal variations, attributable to

  2. Prone Accelerated Partial Breast Irradiation After Breast-Conserving Surgery: Five-year Results of 100 Patients

    SciTech Connect

    Formenti, Silvia C., E-mail: silvia.formenti@nyumc.org [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States); Hsu, Howard; Fenton-Kerimian, Maria [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States)] [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States); Roses, Daniel; Guth, Amber [Department of Surgery, New York University School of Medicine and Langone Medical Center, New York, New York (United States)] [Department of Surgery, New York University School of Medicine and Langone Medical Center, New York, New York (United States); Jozsef, Gabor [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States)] [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States); Goldberg, Judith D. [Division of Biostastistics, Department of Environmental Medicine, New York University School of Medicine and Langone Medical Center, New York, New York (United States)] [Division of Biostastistics, Department of Environmental Medicine, New York University School of Medicine and Langone Medical Center, New York, New York (United States); DeWyngaert, J. Keith [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States)] [Department of Radiation Oncology, New York University School of Medicine and Langone Medical Center, New York, New York (United States)

    2012-11-01

    Purpose: To report the 5-year results of a prospective trial of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation in the prone position. Methods and Materials: Postmenopausal patients with Stage I breast cancer with nonpalpable tumors <2 cm, negative margins and negative nodes, positive hormone receptors, and no extensive intraductal component were eligible. The trial was offered only after eligible patients had refused to undergo standard whole-breast radiotherapy. Patients were simulated and treated on a dedicated table for prone setup. 3D-CRT was delivered at a dose of 30 Gy in five 6-Gy/day fractions over 10 days with port film verification at each treatment. Rates of ipsilateral breast failure, ipsilateral nodal failure, contralateral breast failure, and distant failure were estimated using the cumulative incidence method. Rates of disease-free, overall, and cancer-specific survival were recorded. Results: One hundred patients were enrolled in this institutional review board-approved prospective trial, one with bilateral breast cancer. One patient withdrew consent after simulation, and another patient elected to interrupt radiotherapy after receiving two treatments. Ninety-eight patients were evaluable for toxicity, and, in 1 case, both breasts were treated with partial breast irradiation. Median patient age was 68 years (range, 53-88 years); in 55% of patients the tumor size was <1 cm. All patients had hormone receptor-positive cancers: 87% of patients underwent adjuvant antihormone therapy. At a median follow-up of 64 months (range, 2-125 months), there was one local recurrence (1% ipsilateral breast failure) and one contralateral breast cancer (1% contralateral breast failure). There were no deaths due to breast cancer by 5 years. Grade 3 late toxicities occurred in 2 patients (one breast edema, one transient breast pain). Cosmesis was rated good/excellent in 89% of patients with at least 36 months follow-up. Conclusions: Five-year efficacy and toxicity of 3D-CRT delivered in prone partial breast irradiation are comparable to other experiences with similar follow-up.

  3. Dosimetric Comparison of the Simultaneous Integrated Boost in Whole-Breast Irradiation after Breast-Conserving Surgery: IMRT, IMRT plus an Electron Boost and VMAT

    PubMed Central

    Zhou, Yuan; Chen, Shanyu; Dai, Mingming; Zhou, Juan; Lin, Qin; Chi, Feng

    2015-01-01

    Objectives To compare the target volume coverage and doses to organs at risks (OARs) using three techniques that simultaneous integrated boost (SIB) in whole-breast irradiation (WBI) after breast-conserving surgery, including intensity-modulated radiation therapy (IMRT), IMRT plus an electron boost (IMRT-EB), and volumetric-modulated arc therapy (VMAT). Methods A total of 10 patients with early-stage left-sided breast cancer after breast-conserving surgery were included in this study. IMRT, IMRT-EB and VMAT plans were generated for each patient. Results The conformity index (CI) of the planning target volumes evaluation (PTV-Eval) of VMAT was significantly superior to those of IMRT and IMRT-EB (P < 0.05). The CI of the PTV Eval-boost of VMAT was better than that of IMRT (P = 0.018) and IMRT-EB (P < 0.001), while the CI of the PTV Eval-boost of IMRT was better than that of IMRT-EB (P = 0.002). The V5, V10 and Dmean in ipsilateral lung with VMAT were significantly higher than IMRT (P < 0.05) and IMRT-EB (P < 0.05). The Dmean, V5 and V10 in heart with VMAT were significantly greater than those of IMRT and IMRT-EB (P < 0.05). There was no significant difference in the OARs between IMRT and IMRT-EB (P > 0.05). Conclusions Considered the target volume coverage and radiation dose delivered to the OARs (especially the heart and lung), IMRT may be more suitable for the SIB in WBI than IMRT-EB and VMAT. Additional clinical studies with a larger sample size will be needed to assess the long-term feasibility and efficacy of SIB using different radiotherapy techniques. PMID:25781183

  4. Phosphorylation of Mycobacterium tuberculosis ParB Participates in Regulating the ParABS Chromosome Segregation System

    PubMed Central

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwi?ska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ?parB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis. PMID:25807382

  5. BERKELEY PAR LABBERKELEY PAR LAB Where we ended up

    E-print Network

    California at Berkeley, University of

    LAB Par Lab Timeline 2 Initial Meetings "Berkeley View" Techreport Win UPCRC Competition UPCRC PhaseBERKELEY PAR LABBERKELEY PAR LAB Par Lab: Where we ended up Krste Asanovic, Ras Bodik, Jim Demmel, David Wessel, and Kathy Yelick UC Berkeley Par Lab End-of-Project Party May 30, 2013 #12;BERKELEY PAR

  6. Utilisation de l'essai comete et du biomarqueur gamma-H2AX pour detecter les dommages induits a l'ADN cellulaire par le 5-bromodeoxyuridine post-irradiation

    NASA Astrophysics Data System (ADS)

    La Madeleine, Carole

    Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par le BrdU au niveau cellulaire. Notre hypothese (basee sur des resultats preliminaires effectues dans notre laboratoire) est que l'irradiation de l'ADN cellulaire en presence de BrdU augmentera le nombre de bris simple brin sans toutefois augmenter le nombre de bris double brin. Les resultats presentes dans ce memoire semblent corroborer cette hypothese. Les nouvelles methodes d'analyse, soient l'essai comete et la detection des foci gamma-H2AX remettent en question ce qui a ete dit sur le BrdU au sujet de l'induction des cassures double brin depuis plusieurs annees. L'ensemble de ces nouveaux resultats effectue a l'aide de cellules ayant incorporees du BrdU sont en correlation avec de precedents resultats obtenus dans notre laboratoire sur des oligonucleotides bromes. Ils reaffirment que l'irradiation combinee au BrdU augmente l'induction de bris simple brin mais pas de bris double brin. L'investigation approfondie des mecanismes d'action non elucides du BrdU au niveau cellulaire et son utilisation a des moments strategiques pendant le traitement de radiotherapie pourraient accroitre son efficacite a des fins d'utilisation clinique. Mots cles : 5-bromodeoxyuridine, dimeres interbrins, dommage a l'ADN, essai comete, H2AX, radiosensibilisateur, radiotherapie

  7. Mammographically detected ductal carcinoma in situ of the breast treated with breast-conserving surgery and definitive breast irradiation: long-term outcome and prognostic significance of patient age and margin status

    Microsoft Academic Search

    Lawrence J Solin; Alain Fourquet; Frank A Vicini; Bruce Haffty; Marie Taylor; Beryl McCormick; Marsha McNeese; Lori J Pierce; Christine Landmann; Ivo A Olivotto; Jacques Borger; Jung-Soo Kim; Anne de la Rochefordiere; Delray J Schultz

    2001-01-01

    Purpose: This study was performed to determine the long-term outcome for women with mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast treated with breast-conserving surgery followed by definitive breast irradiation.Methods and Materials: An analysis was performed of 422 mammographically detected intraductal breast carcinomas in 418 women from 11 institutions in North America and Europe. All patients

  8. [Accelerated partial breast irradiation with image-guided intensity-modulated radiotherapy following breast-conserving surgery - preliminary results of a phase II clinical study].

    PubMed

    Mészáros, Norbert; Major, Tibor; Stelczer, Gábor; Zaka, Zoltán; Mózsa, Emõke; Fodor, János; Polgár, Csaba

    2015-06-01

    The purpose of the study was to implement accelerated partial breast irradiation (APBI) by means of image-guided intensity-modulated radiotherapy (IG-IMRT) following breast-conserving surgery (BCS) for low-risk early invasive breast cancer. Between July 2011 and March 2014, 60 patients with low-risk early invasive (St I-II) breast cancer who underwent BCS were enrolled in our phase II prospective study. Postoperative APBI was given by means of step and shoot IG-IMRT using 4 to 5 fields to a total dose of 36.9 Gy (9×4.1 Gy) using a twice-a-day fractionation. Before each fraction, series of CT images were taken from the region of the target volume using a kV CT on-rail mounted in the treatment room. An image fusion software was used for automatic image registration of the planning and verification CT images. Patient set-up errors were detected in three directions (LAT, LONG, VERT), and inaccuracies were adjusted by automatic movements of the treatment table. Breast cancer related events, acute and late toxicities, and cosmetic results were registered and analysed. At a median follow-up of 24 months (range 12-44) neither locoregional nor distant failure was observed. Grade 1 (G1), G2 erythema, G1 oedema, and G1 and G2 pain occurred in 21 (35%), 2 (3.3%), 23 (38.3%), 6 (10%) and 2 (3.3%) patients, respectively. No G3-4 acute side effects were detected. Among late radiation side effects G1 pigmentation, G1 fibrosis, and G1 fat necrosis occurred in 5 (8.3%), 7 (11.7%), and 2 (3.3%) patients, respectively. No ?G2 late toxicity was detected. Excellent and good cosmetic outcome was detected in 45 (75%) and 15 (25%) patients. IG-IMRT is a reproducible and feasible technique for the delivery of APBI following conservative surgery for the treatment of low-risk, early-stage invasive breast carcinoma. Preliminary results are promising, early radiation side effects are minimal, and cosmetic results are excellent. PMID:26035158

  9. Prsente par Maxime DARNON

    E-print Network

    Paris-Sud XI, Université de

    OCH poreux nécessite de revoir les différents procédés par plasmas (gravure, traitements post-gravure) et les des matériaux poreux et hybrides par les plasmas post-gravure est également étudiée. Avec un plasma fluorocarboné, le matériau hybride présente des mécanismes de gravure similaires à ceux d'un SiOCH dense. Le Ti

  10. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Microsoft Academic Search

    Liangfu Chen; Yanhua Gao; Lei Yang; Qinhuo Liu; Xingfa Gu; Guoliang Tian

    2008-01-01

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan’s model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the

  11. Conservation Conservation ResourcesConservation Resources

    E-print Network

    Northwest Power and Conservation Council Conservation ResourcesConservation Resources in thein the Draft 5Draft 5thth Northwest Power PlanNorthwest Power Plan Tom EckmanTom Eckman Manager, Conservation ResourcesManager, Conservation Resources Northwest Power and Conservation CouncilNorthwest Power

  12. Both PHYTOCHROME RAPIDLY REGULATED1 (PAR1) and PAR2 Promote Seedling Photomorphogenesis in Multiple Light Signaling Pathways1[C][W][OPEN

    PubMed Central

    Zhou, Peng; Song, Meifang; Yang, Qinghua; Su, Liang; Hou, Pei; Guo, Lin; Zheng, Xu; Xi, Yulin; Meng, Fanhua; Xiao, Yang; Yang, Li; Yang, Jianping

    2014-01-01

    Arabidopsis (Arabidopsis thaliana) seedlings undergo photomorphogenesis in the light and etiolation in the dark. Light-activated photoreceptors transduce the light signals through a series of photomorphogenesis promoting or repressing factors to modulate many developmental processes in plants, such as photomorphogenesis and shade avoidance. CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is a conserved RING finger E3 ubiquitin ligase, which mediates degradation of several photomorphogenesis promoting factors, including ELONGATED HYPOCOTYL5 (HY5) and LONG HYPOCOTYL IN FAR-RED1 (HFR1), through a 26S proteasome-dependent pathway. PHYTOCHROME RAPIDLY REGULATED1 (PAR1) was first detected as an early repressed gene in both phytochrome A (phyA)-mediated far-red and phyB-mediated red signaling pathways, and subsequent studies showed that both PAR1 and PAR2 are negative factors of shade avoidance in Arabidopsis. However, the role of PAR1 and PAR2 in seedling deetiolation, and their relationships with other photomorphogenesis promoting and repressing factors are largely unknown. Here, we confirmed that both PAR1 and PAR2 redundantly enhance seedling deetiolation in multiple photoreceptor signaling pathways. Their transcript abundances are repressed by phyA, phyB, and cryptochrome1 under far-red, red, and blue light conditions, respectively. Both PAR1 and PAR2 act downstream of COP1, and COP1 mediates the degradation of PAR1 and PAR2 through the 26S proteasome pathway. Both PAR1 and PAR2 act in a separate pathway from HY5 and HFR1 under different light conditions, except for sharing in the same pathway with HFR1 under far-red light. Together, our results substantiate that PAR1 and PAR2 are positive factors functioning in multiple photoreceptor signaling pathways during seedling deetiolation. PMID:24335334

  13. Excimer laser irradiation at 248 nm of wooden archaeological objects and polymeric consolidants used in conservation: a study of cone formation and optimum cleaning parameters

    Microsoft Academic Search

    R. Belli; L. Toniutti; A. Miotello; P. Mosaner; D. Avi

    2008-01-01

    Samples of a prehistoric consolidated vegetable basketry, coming from an important pile building in the North-East of Italy\\u000a (Fiavé Carrera, Trento), had been irradiated with excimer laser pulses to remove the consolidant layer and restore the artifact.\\u000a Some problems, related to the nature of the consolidant resin, were found in the preliminary laser cleaning process. The two\\u000a main obstacles were

  14. Par Mohcine HASSAR Thse prsente

    E-print Network

    Paris-Sud XI, Université de

    Par Mohcine HASSAR Thèse présentée pour l'obtention du grade de Docteur de l'UTC Influence des nano;Université de Technologie de Compiègne THESE Présentée en vue d'obtenir le grade de DOCTEUR En Spécialité : Mécanique Avancée Par Mohcine HASSAR DOCTORAT DELIVRE PAR L'UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE Titre de

  15. DUALITY SOLUTIONS FOR PRESSURELESS GASES, MONOTONE SCALAR CONSERVATION LAWS,

    E-print Network

    d'Orléans, Université

    DUALITY SOLUTIONS FOR PRESSURELESS GASES, MONOTONE SCALAR CONSERVATION LAWS, AND UNIQUENESS Fran pressureless gases, the dynamics of sticky par­ ticles and nonlinear scalar conservation laws with monotone -- scalar conservation laws -- Hamilton­Jacobi equations -- entropy conditions Work partially supported

  16. Accelerated Partial Breast Irradiation: 5-Year Results of the German-Austrian Multicenter Phase II Trial Using Interstitial Multicatheter Brachytherapy Alone After Breast-Conserving Surgery

    SciTech Connect

    Strnad, Vratislav, E-mail: vratislav.strnad@uk-erlangen.d [Department of Radiation Oncology, University Hospital Erlangen, Erlangen (Germany); Hildebrandt, Guido [Department of Radiation Oncology, University Hospital Leipzig, Leipzig (Germany); Department of Radiation Oncology, University Hospital Rostock, Rostock (Germany); Poetter, Richard [Department of Radiation Oncology and Radiobiology, University Hospital AKH Vienna, Vienna (Austria); Hammer, Josef [Department of Radiation Oncology, Barmherzige Schwestern Hospital, Linz (Austria); Hindemith, Marion [Department of Radiation Oncology, University Hospital Leipzig, Leipzig (Germany); Resch, Alexandra [Department of Radiation Oncology and Radiobiology, University Hospital AKH Vienna, Vienna (Austria); Spiegl, Kurt [Department of Radiation Oncology, Barmherzige Schwestern Hospital, Linz (Austria); Lotter, Michael [Department of Radiation Oncology, University Hospital Erlangen, Erlangen (Germany); Uter, Wolfgang [Department for Medical Informatics, Biometry and Epidemiology, University Erlangen-Nuremberg, Erlangen (Germany); Bani, Mayada [Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen (Germany); Kortmann, Rolf-Dieter [Department of Radiation Oncology, University Hospital Leipzig, Leipzig (Germany); Beckmann, Matthias W. [Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen (Germany); Fietkau, Rainer; Ott, Oliver J. [Department of Radiation Oncology, University Hospital Erlangen, Erlangen (Germany)

    2011-05-01

    Purpose: To evaluate the impact of accelerated partial breast irradiation on local control, side effects, and cosmesis using multicatheter interstitial brachytherapy as the sole method for the adjuvant local treatment of patients with low-risk breast cancer. Methods and Materials: 274 patients with low-risk breast cancer were treated on protocol. Patients were eligible for the study if the tumor size was < 3 cm, resection margins were clear by at least 2 mm, no lymph node metastases existed, age was >35 years, hormone receptors were positive, and histologic grades were 1 or 2. Of the 274 patients, 175 (64%) received pulse-dose-rate brachytherapy (D{sub ref} = 50 Gy). and 99 (36%) received high-dose-rate brachytherapy (D{sub ref} = 32.0 Gy). Results: Median follow-up was 63 months (range, 9-103). Only 8 of 274 (2.9%) patients developed an ipsilateral in-breast tumor recurrence at the time of analysis. The 5-year actuarial local recurrence-free survival probability was 98%. The 5- year overall and disease-free survival probabilities of all patients were 97% and 96%, respectively. Contralateral in-breast malignancies were detected in 2 of 274 (0.7%) patients, and distant metastases occurred in 6 of 274 (2.2%). Late side effects {>=}Grade 3 (i.e., breast tissue fibrosis and telangiectasia) occurred in 1 patient (0.4%, 95%CI:0.0-2.0%) and 6 patients (2.2%, 95%CI:0.8-4.7%), respectively. Cosmetic results were good to excellent in 245 of 274 patients (90%). Conclusions: The long-term results of this prospective Phase II trial confirm that the efficacy of accelerated partial breast irradiation using multicatheter brachytherapy is comparable with that of whole breast irradiation and that late side effects are negligible.

  17. Results of a conservative treatment combining induction (neoadjuvant) and consolidation chemotherapy, hormonotherapy, and external and interstitial irradiation in 98 patients with locally advanced breast cancer (IIIA-IIIB)

    SciTech Connect

    Jacquillat, C.; Baillet, F.; Weil, M.; Auclerc, G.; Housset, M.; Auclerc, M.; Sellami, M.; Jindani, A.; Thill, L.; Soubrane, C.

    1988-05-15

    Ninety-eight patients with locally advanced breast cancer (Stage IIIA-IIIB) were entered into a pilot study combining intensive induction (neoadjuvant) chemotherapy (VTMFAP) with or without hormonochemotherapy, external and interstitial radiotherapy, and consolidation chemotherapy with or without hormonochemotherapy. Tumor regression over 50% was observed in 91% patients after chemotherapy, and complete clinical remission occurred in 100% patients after irradiation. The rate of local relapse is 13%. The 3-year disease-free survival is 62% and 3-year global survival is 77%. Initial chemotherapeutic tumor regression greater than 75% is the main predictive factor for disease-free survival.

  18. Conserving Energy.

    ERIC Educational Resources Information Center

    Ember, Lois R.

    1979-01-01

    A report on a recent Technology for Energy Conservation meeting. Topics of the meeting were the need for conservation measures, legistated economic incentives to encourage conservation, and the technology to accomplish this. (BB)

  19. A Conservation Practices for Conserving

    E-print Network

    Kaye, Jason P.

    A Conservation Catalog Practices for Conserving Pennsylvania's Natural Resources #12;#12;A Conservation Catalog 1 Introduction P ennsylvania is a land of great natural resources and Pennsylvania. The Pennsylvania Conservation Catalog is a cooperative effort of the Pennsylvania Conservation Partnership which

  20. Premiere observation de la production de ?0 dans la reaction d+d? ?+ ?0 interdite par la conservation de la symetrie de charge et mesure de la reaction d+d? ?+ ?

    NASA Astrophysics Data System (ADS)

    Goldzahl, L.; Banaigs, J.; Berger, J.; Fabbri, F. L.; Hüfner, J.; Satta, L.

    1991-11-01

    The reaction d+d? ?+ ?0 which is in clear violation of charge symmetry conservation, has been observed for the first time at a laboratory energy of 1.10 GeV in an experiment carried out at the Saturne synchroton at Saclay. The number of ?0's detected corresponds to a differential cross section {d? }/{d? ?(? 0) } = 0.97 ± 0.20 ± 0.15 pb/sr at a centre-of-mass angle of ?c. m. = 107°, where the first error bar refers to the statistical uncertainty and the second to the systematic. The reaction d+d? ?+ ? was measured simultaneously with the ?0 production, leading to a differential cross section of {d? }/{d? ?(?) } = 0.82±0.18±0.10 pb/sr at the slightly larger angle of ?c. m. = 110°. The available predictions of theoretical models of charge symmetry breaking, based upon ?/ ? mixing, fall an order of magnitude below our measurement. However, these predictions for the ?/ ? mixing level might be boosted by the ? threshold (1.121 GeV) proximity, where this experiment is performed.

  1. Brulures par Diluant

    PubMed Central

    Benbrahim, A.; Jerrah, H.; Diouri, M.; Bahechar, N.; Boukind, E.H.

    2009-01-01

    Summary La flamme de diluant est une cause non rare de brûlure dans le contexte marocain. Nous avons jugé intéressant de faire une étude épidémiologique sur la brûlure par flamme de diluant (BFD) au centre national des brûlés (CNB) du CHU Ibn-Rochd de Casablanca. Ce travail a été réalisé sur une période de 10 mois (septembre 2007/juin 2008). Le but du travail est de montrer les caractéristiques de ce type de brûlures pour les prévenir et ce par l'information sur le diluant, produit causant ces brûlures, et ses différents dangers, la brûlure notamment. Durant cette période, nous avons colligé 17 cas de BFD sur un total de 356 patients admis au CNB pour brûlures aiguës toute étiologie confondue. La moyenne d'age des patients concernés est de 32 ans. Ils sont presque tous de sexe masculin (16 hommes/1 femme) et ont des antécédents de toxicomanie et/ou de délinquance. Tous nos patients sont de bas niveau socio-économique et habitent dans des bidonvilles pour la plupart. La brûlure est souvent secondaire à une agression dans la rue (92% des cas). Concernant les caractéristiques de la brûlure, la surface cutanée brûlée moyenne est de 23%; elle est souvent profonde et siège surtout au niveau des membres supérieurs et du tronc. PMID:21991179

  2. The impact of the number of excised axillary nodes and of the percentage of involved nodes on regional nodal failure in patients treated by breast-conserving surgery with or without regional irradiation

    SciTech Connect

    Fortin, Andre [Department of Radiation Oncology, L'Hotel-Dieu de Quebec, Quebec City, Quebec (Canada)]. E-mail: afortin@videotron.ca; Dagnault, Anne [Department of Radiation Oncology, L'Hotel-Dieu de Quebec, Quebec City, Quebec (Canada); Blondeau, Lucie [Department of Radiation Oncology, L'Hotel-Dieu de Quebec, Quebec City, Quebec (Canada); Thi Trinh Thuc Vu [Department of Radiation Oncology, L'Hotel-Dieu de Quebec, Quebec City, Quebec (Canada); Larochelle, Marie [Department of Radiation Oncology, L'Hotel-Dieu de Quebec, Quebec City, Quebec (Canada)

    2006-05-01

    Purpose: After breast-conserving surgery, recommendations for regional nodal radiotherapy are usually based on the number of positive nodes. This number is dependent on the number of nodes removed during the axillary dissection. This study examines whether the percentage of positive nodes may help to select patients for regional radiotherapy. Methods and Materials: A retrospective study was conducted on 1,372 T1-T2 node-positive breast cancer patients treated at L'Hotel-Dieu de Quebec Hospital between 1972 and 1997. Results: Among the patients who did not receive regional radiotherapy, the percentage of involved nodes was significantly associated with axillary failure. Ten-year axillary control rates were 97% and 91% when the percentage of involved nodes was <50% and {>=}50%, respectively (p = 0.007). In addition, regional radiotherapy is always significantly associated with a decrease in overall regional failure (axillary and/or supraclavicular), regardless of the percentage of involved nodes. However, regional radiotherapy reduced the axillary failure rate (2% vs. 9%, p = 0.007) only when more than a specific percentage of nodes was involved ({>=}40% if N1-3 and {>=}50% if N>3 nodes). Conclusions: The percentage of involved nodes should be taken into consideration in selecting patients for regional radiotherapy. Irradiation of the axilla should be reserved for patients with a specific ratio: >40% involved nodes if N1-3 and {>=}50% involved nodes if N>3 nodes.

  3. Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis ?

    PubMed Central

    Lennerz, Jochen K.; Hurov, Jonathan B.; White, Lynn S.; Lewandowski, Katherine T.; Prior, Julie L.; Planer, G. James; Gereau, Robert W.; Piwnica-Worms, David; Schmidt, Robert E.; Piwnica-Worms, Helen

    2010-01-01

    Par-1 is an evolutionarily conserved protein kinase required for polarity in worms, flies, frogs, and mammals. The mammalian Par-1 family consists of four members. Knockout studies of mice implicate Par-1b/MARK2/EMK in regulating fertility, immune homeostasis, learning, and memory as well as adiposity, insulin hypersensitivity, and glucose metabolism. Here, we report phenotypes of mice null for a second family member (Par-1a/MARK3/C-TAK1) that exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal insulin sensitivity. Knockout mice were protected against high-fat diet-induced obesity and displayed attenuated weight gain, complete resistance to hepatic steatosis, and improved glucose handling with decreased insulin secretion. Overnight starvation led to complete hepatic glycogen depletion, associated hypoketotic hypoglycemia, increased hepatocellular autophagy, and increased glycogen synthase levels in Par-1a?/? but not in control or Par-1b?/? mice. The intercrossing of Par-1a?/? with Par-1b?/? mice revealed that at least one of the four alleles is necessary for embryonic survival. The severity of phenotypes followed a rank order, whereby the loss of one Par-1b allele in Par-1a?/? mice conveyed milder phenotypes than the loss of one Par-1a allele in Par-1b?/? mice. Thus, although Par-1a and Par-1b can compensate for one another during embryogenesis, their individual disruption gives rise to distinct metabolic phenotypes in adult mice. PMID:20733003

  4. THSE DE DOCTORAT Prsente par

    E-print Network

    Paris-Sud XI, Université de

    (Maître de Conférences HDR, Université de Toulon) Directeur de thèse Asma SAKKA HLAILI (Professeur desAvantAvantAvant----ProposProposProposPropos Cette thèse a été co-dirigée par une partie tunisienne et par une partie française. En Tunisie, Mme Asma impactées : Faouzi HERZI, Asma SAKKA HLAILI, Christophe LE POUPON, Hassine HADJ MABROUK, Stéphane MOUNIER

  5. A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer

    SciTech Connect

    Suh, W. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)]. E-mail: wsuh@lroc.harvard.edu; Pierce, Lori J. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States); Vicini, Frank A. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States); Hayman, James A. [Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)

    2005-07-01

    Purpose: To assess, if and for whom, there are cost savings associated with alternate breast radiotherapy (RT) techniques when compared with the conventional external beam-based whole-breast RT with a boost (WBRT-B). Methods and Materials: Treatment planning and delivery utilization data were modeled for eight different breast RT techniques: (1) WBRT-B: 60 Gy in 30 fractions; (2) WBRT: 50 Gy in 25 fractions; (3) WBRT-accelerated (AC): 42.5 Gy in 16 fractions; (4) WBRT-intensity-modulated RT (IMRT): 60 Gy in 30 fractions; (5) accelerated partial breast irradiation (APBI)-IC, MammoSite: 34 Gy in 10 twice-daily fractions; (6) APBI-IT, HDR interstitial: 34 Gy in 10 twice-daily fractions; (7) APBI three-dimensional conformal RT (3D-CRT): 38.5 Gy in 10 twice-daily fractions; or (8) APBI-IMRT: 38.5 Gy in 10 twice-daily fractions. Costs incurred by payer (i.e., direct medical costs; 2003 Medicare Fee Schedule) and patient (i.e., direct nonmedical costs; time and travel) were estimated. Total societal costs were then calculated for each treatment approach. Results: Not all efforts to reduce overall treatment time result in total cost savings. The least expensive partial breast-based RT approaches were the external beam techniques (APBI-3D-CRT, APBI-IMRT). Any reduced cost to patients for the HDR brachytherapy-based APBI regimens were overshadowed by substantial increases in cost to payers, resulting in higher total societal costs; the cost of HDR treatment delivery was primarily responsible for the increased direct medical cost. For the whole breast-based RT approaches, treating without a boost (WBRT) or with WBRT-AC reduced total costs. Overall, WBRT-AC was the least costly of all the regimens, in terms of costs to society; APBI approaches, in general, were favored over whole-breast techniques when only considering costs to patients. Conclusions: Based on societal cost considerations, WBRT-AC appears to be the preferred approach. If one were to pursue a partial-breast RT regimen to minimize patient costs, it would be more advantageous from a societal perspective to pursue external beam-based approaches such as APBI-3D-CRT or APBI-IMRT in lieu of the brachytherapy-based regimens.

  6. Conservation strategy: Making it conserve

    Microsoft Academic Search

    Frank Fisher

    1984-01-01

    Australian governments are currently developing conservation strategy. This paper seeks to raise critical awareness to the process. It suggests: 1. even the most diligent efforts (Victorian Government) treat conservation as a mechanical problem2. for conservation strategy to conserve it must recognise that our ways of life require fundamental change3. we might begin by using General Systems Theory to promote a

  7. Simultaneous Integrated Boost Irradiation After Breast-Conserving Surgery: Physician-Rated Toxicity and Cosmetic Outcome at 30 Months' Follow-Up

    SciTech Connect

    Bantema-Joppe, Enja J.; Schilstra, Cornelis [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Bock, Geertruida H. de [Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Dolsma, Wil V.; Busz, Dianne M.; Langendijk, Johannes A. [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands); Maduro, John H., E-mail: j.h.maduro@umcg.nl [Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen (Netherlands)

    2012-07-15

    Purpose: To evaluate toxicity and cosmetic outcome (CO) in breast cancer survivors treated with three-dimensional conformal radiotherapy with a hypofractionated, simultaneous integrated boost (3D-CRT-SIB) and to identify risk factors for toxicity, with special focus on the impact of age. Methods and Materials: Included were 940 consecutive disease-free patients treated for breast cancer (Stage 0-III) with 3D-CRT-SIB, after breast-conserving surgery, from 2005 to 2010. Physician-rated toxicity (Common Terminology Criteria for Adverse Events version 3.0) and CO were prospectively assessed during yearly follow-up, up to 5 years after radiotherapy. Multivariate logistic regression analyses using a bootstrapping method were performed. Results: At 3 years, toxicity scores of 436 patients were available. Grade {>=}2 fibrosis in the boost area was observed in 8.5%, non-boost fibrosis in 49.4%, pain to the chest wall in 6.7%, and fair/poor CO in 39.7% of cases. Radiotherapy before chemotherapy was significantly associated with grade {>=}2 boost fibrosis at 3 years (odds ratio [OR] 2.8, 95% confidence interval [CI] 1.3-6.0). Non-boost fibrosis was associated with re-resection (OR 2.2, 95% CI 1.2-4.0) and larger tumors (OR 1.1, 95% CI 1.0-1.1). At 1 year, chest wall pain was significantly associated with high boost dosage (OR 2.1, 95% CI 1.2-3.7) and younger age (OR 0.4, 95% CI 0.2-0.7). A fair/poor CO was observed more often after re-resection (OR 4.5, 95% CI 2.4-8.5), after regional radiotherapy (OR 2.9, 95% CI 1.2-7.1), and in larger tumors (OR 1.1, 95% CI 1.0-1.1). Conclusions: Toxicity and CO are not impaired after 3D-CRT-SIB. Fibrosis was not significantly associated with radiotherapy parameters. Independent risk factors for fibrosis were chemotherapy after radiotherapy, re-resection, and larger tumor size. Re-resection was most predictive for worse CO. Age had an impact on chest wall pain occurrence.

  8. Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin ?1/FAK Signaling in Medulloblastoma

    PubMed Central

    Nalla, Arun Kumar; Asuthkar, Swapna; Bhoopathi, Praveen; Gujrati, Meena; Dinh, Dzung H.; Rao, Jasti S.

    2010-01-01

    Background Despite effective radiotherapy for the initial stages of cancer, several studies have reported the recurrence of various cancers, including medulloblastoma. Here, we attempt to capitalize on the radiation-induced aggressive behavior of medulloblastoma cells by comparing the extracellular protease activity and the expression pattern of molecules, known to be involved in cell adhesion, migration and invasion, between non-irradiated and irradiated cells. Methodology/Principal Findings We identified an increase in invasion and migration of irradiated compared to non-irradiated medulloblastoma cells. RT-PCR analysis confirmed increased expression of uPA, uPAR, focal adhesion kinase (FAK), N-Cadherin and integrin subunits (e.g., ?3, ?5 and ?1) in irradiated cells. Furthermore, we noticed a ?2-fold increase in tyrosine phosphorylation of FAK in irradiated cells. Immunoprecipitation studies confirmed increased interaction of integrin ?1 and FAK in irradiated cells. In addition, our results show that overexpression of uPAR in cancer cells can mimic radiation-induced activation of FAK signaling. Moreover, by inhibiting FAK phosphorylation, we were able to reduce the radiation-induced invasiveness of the cancer cells. In this vein, we studied the effect of siRNA-mediated knockdown of uPAR on cell migration and adhesion in irradiated and non-irradiated medulloblastoma cells. Downregulation of uPAR reduced the radiation-induced adhesion, migration and invasion of the irradiated cells, primarily by inhibiting phosphorylation of FAK, Paxillin and Rac-1/Cdc42. As observed from the immunoprecipitation studies, uPAR knockdown reduced interaction among the focal adhesion molecules, such as FAK, Paxillin and p130Cas, which are known to play key roles in cancer metastasis. Pretreatment with uPAR shRNA expressing construct reduced uPAR and phospho FAK expression levels in pre-established medulloblastoma in nude mice. Conclusion/Significance Taken together, our results show that radiation enhances uPAR-mediated FAK signaling and by targeting uPAR we can inhibit radiation-activated cell adhesion and migration both in vitro and in vivo. PMID:20886051

  9. Conservative logic

    Microsoft Academic Search

    Edward Fredkin; Tommaso Toffoli

    1982-01-01

    Conservative logic is a comprehensive model of computation which explicitly reflects a number of fundamental principles of physics, such as the reversibility of the dynamical laws and the conservation of certainadditive quantities (among which energy plays a distinguished role). Because it more closely mirrors physics than traditional models of computation, conservative logic is in a better position to provide indications

  10. Evaluation of Single Nucleotide Polymorphisms (SNPs) in the p53 Binding Protein 1 (TP53BP1) Gene in Breast Cancer Patients Treated With Breast-Conserving Surgery and Whole-Breast Irradiation (BCS + RT)

    SciTech Connect

    Haffty, Bruce G., E-mail: hafftybg@umdnj.ed [Robert Wood Johnson Medical School-Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ (United States); Goyal, Sharad; Kulkarni, Diptee; Green, Camille; Vazquez, Alexi; Schiff, Devora [Robert Wood Johnson Medical School-Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ (United States); Moran, Meena S. [Yale University, New Haven, CT (United States); Yang Qifeng [Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan (China); Ganesan, Shridar; Hirsfield, Kim M. [Robert Wood Johnson Medical School-Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ (United States)

    2011-06-01

    Purpose: TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair. The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT). Methods and Materials: The population consisted of 176 premenopausal women treated with BCS + RT (median follow-up, 12 years). Genomic deoxyribonucleic acid was processed by use of TaqMan assays. Each allele for rs560191 was either C or G, so each patient was therefore classified as CC, CG, or GG. Patients were grouped as GG if they were homozygous for the variant G allele or CC-CG if they carried at least one copy of the common C allele (CC or CG). Results: Of the 176 women, 124 (71%) were CC-CG and 52 (29%) were GG. The mean age was 44 years for GG vs. 38 years for CC-CG (p < 0.001). GG was more common in African-American women than white women (69% vs. 13%, p < 0.001) and more commonly estrogen receptor negative (70% vs. 49%, p = 0.02). There were no significant correlations of rs560191 with other critical variables. Despite the fact that GG patients were older, the 10-year rate of local relapses was higher (22% for GG vs. 12% for CC-CG, p = 0.04). Conclusions: This novel avenue of investigation of polymorphisms in radiation repair/response genes in patients treated with BCS + RT suggests a correlation to local relapse. Additional evaluation is needed to assess the biological and functional significance of these single nucleotide polymorphisms, and larger confirmatory validation studies will be required to determine the clinical implications.

  11. Par Pond vegetation status 1996

    SciTech Connect

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned.

  12. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis.

    PubMed

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; Ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C Arnold

    2015-06-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is diminished in both PAR-1 and PAR-2 deficient mice. We thus have been suggested that combined inactivation of PAR-1 and PAR-2 would be more effective in blocking pulmonary fibrosis. Human and murine fibroblasts were stimulated with PAR-1 and PAR-2 agonists in the absence or presence of specific PAR-1 or PAR-2 antagonists after which fibrotic markers like collagen and smooth muscle actin were analysed by Western blot. Pulmonary fibrosis was induced by intranasal instillation of bleomycin into wild-type and PAR-2 deficient mice with or without a specific PAR-1 antagonist (P1pal-12). Fibrosis was assessed by hydroxyproline quantification and (immuno)histochemical analysis. We show that specific PAR-1 and/or PAR-2 activating proteases induce fibroblast migration, differentiation and extracellular matrix production. Interestingly, however, combined activation of PAR-1 and PAR-2 did not show any additive effects on these pro-fibrotic responses. Strikingly, PAR-2 deficiency as well as pharmacological PAR-1 inhibition reduced bleomycin-induced pulmonary fibrosis to a similar extent. PAR-1 inhibition in PAR-2 deficient mice did not further diminish bleomycin-induced pulmonary fibrosis. Finally, we show that the PAR-1-dependent pro-fibrotic responses are inhibited by the PAR-2 specific antagonist. Targeting PAR-1 and PAR-2 simultaneously is not superior to targeting either receptor alone in bleomycin-induced pulmonary fibrosis. We postulate that the pro-fibrotic effects of PAR-1 require the presence of PAR-2. PMID:25689283

  13. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    PubMed Central

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is diminished in both PAR-1 and PAR-2 deficient mice. We thus have been suggested that combined inactivation of PAR-1 and PAR-2 would be more effective in blocking pulmonary fibrosis. Human and murine fibroblasts were stimulated with PAR-1 and PAR-2 agonists in the absence or presence of specific PAR-1 or PAR-2 antagonists after which fibrotic markers like collagen and smooth muscle actin were analysed by Western blot. Pulmonary fibrosis was induced by intranasal instillation of bleomycin into wild-type and PAR-2 deficient mice with or without a specific PAR-1 antagonist (P1pal-12). Fibrosis was assessed by hydroxyproline quantification and (immuno)histochemical analysis. We show that specific PAR-1 and/or PAR-2 activating proteases induce fibroblast migration, differentiation and extracellular matrix production. Interestingly, however, combined activation of PAR-1 and PAR-2 did not show any additive effects on these pro-fibrotic responses. Strikingly, PAR-2 deficiency as well as pharmacological PAR-1 inhibition reduced bleomycin-induced pulmonary fibrosis to a similar extent. PAR-1 inhibition in PAR-2 deficient mice did not further diminish bleomycin-induced pulmonary fibrosis. Finally, we show that the PAR-1-dependent pro-fibrotic responses are inhibited by the PAR-2 specific antagonist. Targeting PAR-1 and PAR-2 simultaneously is not superior to targeting either receptor alone in bleomycin-induced pulmonary fibrosis. We postulate that the pro-fibrotic effects of PAR-1 require the presence of PAR-2. PMID:25689283

  14. Exploration of locomotion in the ParA/ParB system

    NASA Astrophysics Data System (ADS)

    Jindal, Lavisha; Emberly, Eldon

    2015-03-01

    In many bacteria the ParA/ParB system is responsible for actively segregating DNA during replication. ParB precessively moves by hydrolyzing DNA bound ParA-ATP forming a depleted ParA region in its wake. Recent in-vitro experiments have shown that a ParB covered bead can traverse a ParA bound DNA substrate. It has been suggested that the formation of a gradient in ParA leads to diffusion-ratchet like motion of the ParB bead but its origin and potential consequences requires investigation. We have developed a deterministic model for the in-vitro ParA/ParB system and show that any amount of spatial noise in ParA can lead to the spontaneous formation of its gradient. The velocity of the bead is independent of this noise but depends on the scale over which ParA exerts a force on the bead and the scale over which ParB hydrolyzes ParA from the substrate. There is a particular ratio of these scales at which the velocity is a maximum. We also explore the effects of cooperative vs independent rebinding of ParA to the substrate. Our model shows how the driving force for ParB originates and highlights necessary conditions for directed motion in the in-vitro system that may provide insight into the in-vivo behaviour of the ParA/ParB system.

  15. INTERACTION ENTRE DISLOCATIONS ET DFAUTS PONCTUELS CRS PAR BOMBARDEMENT LECTRONIQUE DANS L'ARGENT

    E-print Network

    Boyer, Edmond

    1978) Résumé. 2014 Le module élastique et le frottement intérieur de l'argent bombardé par des effect. Abstract. 2014 The elastic modulus and internal friction of silver irradiated by electrons [6], mais formellement, les équations qui donnent le frottement intérieur et le défaut de module

  16. Conservation Online

    NSDL National Science Digital Library

    Started as a germ of an idea back in 1987 (on a real, live bulletin board, as opposed to an electronic one), Conservation Online (CoOL) has been providing online resources for conservation professionals since 1993. As its website announces, it is a "full text library of conservation information," covering a wide array of topics ranging from digital imaging to reprographics, and quite a bit of material in between. By clicking on any given topic, visitors will receive a brief overview of the subject, its terminology, and then a list of general online resources for consideration. Another nice feature of the site is the mailing list archive, which contain the archives of various queries submitted to different professional conservation groups, such as the Association of Moving Image Archivists, the Textiles Conservation Discussion List, and the Conservation Framer's Mailing List. The site is rounded out by a timeline that traces the CoOL's history from the summer of 1987 to July 2003.

  17. The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae

    PubMed Central

    Attaiech, Laetitia; Minnen, Anita; Kjos, Morten; Gruber, Stephan

    2015-01-01

    ABSTRACT ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic human pathogen Streptococcus pneumoniae contains four parS sequences located close to the origin of replication which are bound by ParB. Using chromatin immunoprecipitation (ChIP), we found here that ParB spreads out from one of these parS sites, parS(?1.6°), for more than 5 kb and occupies the nearby comCDE operon, which drives competence development. Competence allows S. pneumoniae to take up DNA from its environment, thereby mediating horizontal gene transfer, and is also employed as a general stress response. Mutating parS(?1.6°) or deleting parB resulted in transcriptional up-regulation of comCDE and ssbB (a gene belonging to the competence regulon), demonstrating that ParB acts as a repressor of competence. However, genome-wide transcription analysis showed that ParB is not a global transcriptional regulator. Different factors, such as the composition of the growth medium and antibiotic-induced stress, can trigger the sensitive switch driving competence. This work shows that the ParB-parS chromosome segregation machinery also influences this developmental process. PMID:26126852

  18. Energy Conservation.

    ERIC Educational Resources Information Center

    Canadian Education Association, Toronto (Ontario).

    A questionnaire distributed in March 1977 to 71 Canadian school systems sought information on any energy conservation programs that the school boards might have undertaken. Based on the 43 replies received, a 60 percent response rate, the findings are reported and some suggestions are offered. The first section on energy conservation at the board…

  19. Energy Conservation.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Educational Management, Eugene, OR.

    This chapter of "The Best of the Best of ERIC" contains 14 annotations of documents and journal articles on energy conservation, all of which are indexed in the ERIC system. Materials on teaching energy conservation to students, the energy crisis and its impact on school finances, building heating and cooling, and other topics are annotated. (DS)

  20. Conservation Regional Conservation SavingsRegional Conservation Savings

    E-print Network

    1 Northwest Power and Conservation Council Regional Conservation SavingsRegional Conservation the Plan''s Targets?s Targets? March 14, 2008 slide 2 Northwest Power and Conservation Council 55thth Plan Conservation ResourcePlan Conservation Resource Acquisition TargetsAcquisition Targets 20052005 ­­ 2009 = 700 a

  1. Amorphization of ?-Quartz under Irradiation

    NASA Astrophysics Data System (ADS)

    Douillard, L.; Duraud, J. P.

    1996-12-01

    The course of radiation induced damage produced in ?-quartz by neutrons, ions, electrons or photons — commonly known as metamictization — has been re-analyzed by careful comparison of available experimental data. Specific interest was devoted to confront experimental metamict state features with current structural models. It comes out that the metamict state of irradiated quartz should exhibit some structural characteristics of the modulated structure proposed for vitreous silica. The metamictization process is consistent with a structural relaxation process of a highly defective quartz matrix. According to this new point defect analysis, structural relaxation should be triggered by a critical concentration of oxygen vacancy point defects likely to significantly lower the connectivity of the SiO{2} network. Various experimental results are interpreted by incorporating the influence of the SiO{2} crystalline polymorph and the influence of the nature of the irradiating particle to the point defect model. Nous avons étudié les modifications de propriétés et de structures de monocristaux de quartz ?, consécutives à une irradiation sévère par des neutrons, des ions, des électrons ou des photons. Ce phénomène d'altération du quartz sous irradiation porte le nom de métamictisation. Notre travail exploite les recoupements de travaux antérieurs. Une attention particulière a été portée à la confrontation entre les données structurales expérimentales disponibles sur l'état métamicte du quartz et les modèles structuraux proposés. L'état métamicte du quartz présente ainsi les caractéristiques structurales du modèle de structure modulée, avancé pour décrire la structure de la silice thermique. Le mécanisme de métamictisation procéderait par relaxation de la matrice cristalline fortement endommagée. Ce phénomène de relaxation serait initié par l'apparition de concentration critique de défauts ponctuels de type lacunes d'oxygène responsables d'une forte augmentation des degrés de liberté des tétraèdres élémentaires SiO{4} au sein du crystal. Ce modèle de défaut ponctuel permet, par la prise en compte de la nature de la forme cristalline du dioxyde de silicium et la nature du projectile utilisé, de rendre compte de l'essentiel des donnés expérimentales.

  2. Prsente par Adel EL OMRI

    E-print Network

    Paris-Sud XI, Université de

    THESE Présentée par Adel EL OMRI Pour l'obtention du GRADE DE DOCTEUR Spécialité : Génie Industriel, this dissertation would not be possible. Adel tel-00453322,version1-4Feb2010 #12;tel-00453322,version1-4Feb2010 #12

  3. Mmoire prsent par Franois Renard

    E-print Network

    Mémoire présenté par François Renard Laboratoire de Géophysique Interne et Tectonophysique presented by François Renard Laboratoire de Géophysique Interne et Tectonophysique Observatoire des Sciences mécaniques. D'autre part de nouveaux thèmes de recherche ont été initiés: étude expérimentale du frottement

  4. Water Conservation

    NSDL National Science Digital Library

    This activity was developed to get students thinking about the many ways that people use freshwater and how we can conserve this precious and fundamental natural resource. Students will watch a short documentary describing issues related to clean water availability, analyze water-use data and start to think about how they consume and can conserve water. This background knowledge will lead to students collecting data about their own water use and finding areas in their lives to conserve water. This activity uses the 5E instructional model and is part of the "Survivor Earth" series of one-hour lessons.

  5. PRECISION CONSERVATION

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Precision conservation utilizes a set of technologies and procedures that link mapped variables with analytical capabilities to appropriate management actions. It requires the integration of spatial technologies of global positioning systems, remote sensing and geographic information systems with t...

  6. Conservation Presentation.

    ERIC Educational Resources Information Center

    Friday, Gerald

    2001-01-01

    Introduces a project in which students teach about the importance of recycling and conservation by presenting demonstrations. Includes demonstrations on water, plastic, and other recycling products such as steel. (YDS)

  7. Energy Conservation

    ERIC Educational Resources Information Center

    Abelson, Philip H.

    1972-01-01

    Comments on The Potential for Energy Conservation,'' a study by the Office of Emergency Preparedness, emphasizing the coming dependence on foreign oil, and presses for government influence to encourage development of more efficient cars. (AL)

  8. Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway

    PubMed Central

    Yang, Rui; Kong, Eryan; Jin, Jing; Hergovich, Alexander; Püschel, Andreas W.

    2014-01-01

    ABSTRACT The morphology and polarized growth of cells depend on pathways that control the asymmetric distribution of regulatory factors. The evolutionarily conserved Ndr kinases play important roles in cell polarity and morphogenesis in yeast and invertebrates but it is unclear whether they perform a similar function in mammalian cells. Here, we analyze the function of mammalian Ndr1 and Ndr2 (also known as STK38 or STK38L, respectively) in the establishment of polarity in neurons. We show that they act downstream of the tumor suppressor Rassf5 and upstream of the polarity protein Par3 (also known as PARD3). Rassf5 and Ndr1 or Ndr2 are required during the polarization of hippocampal neurons to prevent the formation of supernumerary axons. Mechanistically, the Ndr kinases act by phosphorylating Par3 at Ser383 to inhibit its interaction with dynein, thereby polarizing the distribution of Par3 and reinforcing axon specification. Our results identify a novel Rassf5–Ndr–Par3 signaling cascade that regulates the transport of Par3 during the establishment of neuronal polarity. Their role in neuronal polarity suggests that Ndr kinases perform a conserved function as regulators of cell polarity. PMID:24928906

  9. Moessbauer spectroscopy study of aging and fast neutron irradiation effects in a copper-rich Cu Fe alloy

    Microsoft Academic Search

    T. H. Jr. Gould; D. H. Vincent

    1974-01-01

    RBsum6. - Les effets du recuit thermique et de l'irradiation par des neutrons rapides sur les pro- cessus de precipitation dans un alliage Cu-Fe (0,6 % at) ont Ctt ktudiks par spectroscopic Mossbauer ainsi que par mesures de rbistivitk. Les caractkristiques des spectres d'echantillons ayant subi un recuit en solution et d'kchantillons vieillis servent de base h l'interprktation des effets

  10. CARDIAC COUNTERCLOCKWISE ROTATION IS A RISK FACTOR FOR HIGH-DOSE IRRADIATION TO THE LEFT ANTERIOR DESCENDING CORONARY ARTERY IN PATIENTS WITH LEFT-SIDED BREAST CANCER WHO RECEIVING ADJUVANT RADIOTHERAPY AFTER BREAST-CONSERVING SURGERY

    PubMed Central

    TANAKA, HIDEKAZU; HAYASHI, SHINYA; HOSHI, HIROAKI

    2014-01-01

    ABSTRACT Patients irradiated for left-sided breast cancer have higher incidence of cardiovascular disease than those receiving irradiation for right-sided breast cancer. Most abnormalities were in the left anterior descending (LAD) coronary artery territory. We analyzed the relationships between preoperative examination results and irradiation dose to the LAD artery in patients with left-sided breast cancer. Seventy-one patients receiving breast radiotherapy were analyzed. The heart may rotate around longitudinal axis, showing either clockwise or counterclockwise rotation (CCWR). On electrocardiography, the transition zone (TZ) was judged in precordial leads. CCWR was considered to be present if TZ was at or to the right of V3. The prescribed dose was 50 Gy in 25 fractions. The maximum (Dmax) and mean (Dmean) doses to the LAD artery and the volumes of the LAD artery receiving at least 20 Gy, 30 Gy and 40 Gy (V20Gy, V30Gy and V40Gy, respectively) were significantly higher in CCWR than in the non-CCWR patients. On multivariate analysis, TZ was significantly associated with Dmax, Dmean, V20Gy, V30Gy, and V40Gy. CCWR is a risk factor for high-dose irradiation to the LAD artery. Electrocardiography is useful for evaluating the cardiovascular risk of high-dose irradiation to the LAD artery. PMID:25741035

  11. Water Conservation

    NSDL National Science Digital Library

    2005-01-01

    In this lesson, students study the availability of water on Earth and discuss methods that can be used to purify and conserve this critical resource. Using multimedia interactives, video, and classroom activities, they will identify sources of fresh water available for consumption, understand the need for water conservation, and compare the benefits and drawbacks of different water management techniques. They will also assess how much water they and their families typically use, and think about ways to reduce their water usage. Finally, students explore different techniques being employed for water management around the world, including the use of dams to create reservoirs.

  12. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes

    PubMed Central

    Lioy, Virginia S.; Volante, Andrea; Soberón, Nora E.; Lurz, Rudi; Ayora, Silvia; Alonso, Juan C.

    2015-01-01

    In Firmicutes, small homodimeric ParA-like (?2) and ParB-like (?2) proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (?:YFP)2 binding to parS facilitates plasmid clustering in the cytosol. (?:GFP)2 requires ATP binding but not hydrolysis to localize onto the cell’s nucleoid as a fluorescent cloud. The interaction of (?:CFP)2 or ?2 bound to the nucleoid with (?:YFP)2 foci facilitates plasmid capture, from a very broad distribution, towards the nucleoid and plasmid pairing. parS-bound ?2 promotes redistribution of (?:GFP)2, leading to the dynamic release of (?:GFP)2 from the nucleoid, in a process favored by ATP hydrolysis and protein-protein interaction. (?D60A:GFP)2, which binds but cannot hydrolyze ATP, also forms unstable complexes on the nucleoid. In the presence of ?2, (?D60A:GFP)2 accumulates foci or patched structures on the nucleoid. We propose that (?:GFP)2 binding to different nucleoid regions and to ?2-parS might generate (?:GFP)2 gradients that could direct plasmid movement. The iterative pairing and unpairing cycles may tether plasmids equidistantly on the nucleoid to ensure faithful plasmid segregation by a mechanism compatible with the diffusion-ratchet mechanism as proposed from in vitro reconstituted systems. PMID:26161642

  13. Colorful Conservation

    ERIC Educational Resources Information Center

    Skophammer, Karen

    2011-01-01

    Some people only think about conservation on Earth Day. Being in the "art business" however, this author is always conscious of the many products she thinks get wasted when they could be reused, recycled, and restored--especially in a school building and art room. In this article, she describes an art lesson that allows students to paint…

  14. [Conservation Units.

    ERIC Educational Resources Information Center

    Texas Education Agency, Austin.

    Each of the six instructional units deals with one aspect of conservation: forests, water, rangeland, minerals (petroleum), and soil. The area of the elementary school curriculum with which each correlates is indicated. Lists of general and specific objectives are followed by suggested teaching procedures, including ideas for introducing the…

  15. Widely Conserved Signaling Pathways in the Establishment of Cell Polarity

    PubMed Central

    McCaffrey, Luke Martin; Macara, Ian G.

    2009-01-01

    How are the asymmetric distributions of proteins, lipids, and RNAs established and maintained in various cell types? Studies from diverse organisms show that Par proteins, GTPases, kinases, and phosphoinositides participate in conserved signaling pathways to establish and maintain cell polarity. PMID:20066082

  16. Conservation pendant 5 ans de graines de peupliers noirs (Populus nigra L.)

    E-print Network

    Paris-Sud XI, Université de

    Conservation pendant 5 ans de graines de peupliers noirs (Populus nigra L.) Claudine MULLER * avec nigra peuvent se conserver pendant au moins 5 ans si leur teneur en eau est de 7 à 8 p. 100 et si elles nigra quelques précisions sont données par ZSUFFA en 1974 : les graines de cette espèce peuvent être

  17. Statistical treatment of the PAR variability and its application to willow coppice

    Microsoft Academic Search

    J Ross; M Sulev; P Saarelaid

    1998-01-01

    For characterization of spatial variability of the global photosynthetically active radiation (PAR) Q at different depths in a plant canopy a new statistical treatment has been developed. It is based on the use of the irradiance probability density function (IPDF) which is divided into three parts: IPDF for umbra fuQ, for penumbra fpQ and for sunflecks fsQ. In umbra, IPDF

  18. Soft tissue sarcoma of the extremity. Limb salvage after failure of combined conservative therapy

    Microsoft Academic Search

    Charles Catton; Aileen Davis; Robert Bell; Brian O'Sullivan; Victor Fornasier; Jay Wunder; Michael McLean

    1996-01-01

    Purpose: To assess the results of salvage therapy using surgery alone or surgery and re-irradiation for patients with locally recurrent extremity soft tissue sarcoma (STS) following conservative surgery and radiotherapy.Materials and methods: 25 patients with locally recurrent STS after conservative surgery and irradiation were assessed beteween 1990 and 1995. Two patients with concurrent systemic relapse were treated palliatively. Seven patients

  19. PAR and Supply Distribution System The PAR Program is administered by Materials Logistics (Central Distribution)

    E-print Network

    Oliver, Douglas L.

    Logistics (Central Distribution) Services, a division of Materials Management. · The PAR Program is focused#12;PAR and Supply Distribution System OVERVIEW · The PAR Program is administered by Materials of completing the services. · Provide supply distribution and replenishment services that met the needs

  20. PRODUCTION D'OSCILLATIONS PAR LES DIODES A EFFET TUNNEL Par REN MARCHANDEAU,

    E-print Network

    Paris-Sud XI, Université de

    101 A. PRODUCTION D'OSCILLATIONS PAR LES DIODES A EFFET TUNNEL Par RENÉ MARCHANDEAU, Laboratoire d'oscillations par une diode à effet tunnel, dans un circuit résonnant parallèle, est étudiée au moyen d'une méthode The generation of oscillations by a tunnel diode in a parallel tuned circuit is studied by means of a graphical

  1. MTHODE DE RALISATION DE COUCHES MINCES DE CdTe PAR TRANSPORT GAZEUX Par C. PIAGET,

    E-print Network

    Paris-Sud XI, Université de

    201. MÉTHODE DE RÉALISATION DE COUCHES MINCES DE CdTe PAR TRANSPORT GAZEUX Par C. PIAGET dépôt de couches minces de CdTe (transport par l'iode et évaporation sous vide) sont transposées des basses pressions à des pressions voisines de l'atmosphère. La dissociation et la cristallisation du CdTe

  2. PAR for the Course: A Congruent Pedagogical Approach for a PAR Methods Class

    ERIC Educational Resources Information Center

    Hammond, Joyce D.; Hicks, Maria; Kalman, Rowenn; Miller, Jason

    2005-01-01

    In the past two years, three graduate students and a senior faculty member have co-taught a participatory action research (PAR) course to undergraduate and graduate students. In this article the co-teachers advocate a set of pedagogical principles and practices in a PAR-oriented classroom that establishes congruency with community PAR projects in…

  3. COLLIMATION DU RAYONNEMENT GAMMA PAR UN CANAL CYLINDRIQUE CIRCULAIRE Par C. KELLERSHOHN et P. PELLERIN,

    E-print Network

    Paris-Sud XI, Université de

    81 A COLLIMATION DU RAYONNEMENT GAMMA PAR UN CANAL CYLINDRIQUE CIRCULAIRE Par C. KELLERSHOHN et P'apprécier le degré de collimation d'un rayonnement gamma par un canal cylindrique dans un matériau absorbant. Application au cas de la raie 364 KeV de 131I et d'un canal à parois de plomb. LE JOURNAL DE PHYSIQUE ET LE

  4. Irradiated foods

    MedlinePLUS

    ... and reduces the risk of food poisoning . Food irradiation is used in many countries. It was first approved in the U.S. to prevent sprouts on white potatoes and for the control of insects on wheat and in certain spices and seasonings.

  5. December 18, 2008 Conservation

    E-print Network

    1 December 18, 2008 Northwest Power and Conservation Council Northwest Power and Conservation Council Sixth Northwest Conservation & Electric Power Plan Wind Resource Assessment Jeff King Northwest Power and Conservation Council Generating Resources Advisory Committee Portland, OR December 18, 2008

  6. December 18, 2008 Conservation

    E-print Network

    1 December 18, 2008 Northwest Power and Conservation Council Northwest Power and Conservation Council Sixth Northwest Conservation & Electric Power Plan Resource Assessment Status and Remaining Work Jeff King Northwest Power and Conservation Council Generating Resources Advisory Committee Portland

  7. Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site†

    PubMed Central

    Nieman, Marvin T.; Schmaier, Alvin H.

    2008-01-01

    Investigations determined the critical amino acids for ?-thrombin’s interaction with protease activated receptors 1 and 4 (PAR1 and PAR4) at the thrombin cleavage site. Recombinant PAR1-wild type (wt) exodomain was cleaved by ?-thrombin with a Km of 28 ?M, a kcat of 340 s-1 and kcat/Km of 1.2×107. When the P4 or P2 position was mutated to alanine, PAR1-L38A or PAR1-P40A, respectively, the Km was unchanged, 29 or 23 ?M, respectively; however the kcat and kcat/Km were reduced in each case. In contrast, when Asp39 at P3 was mutated to alanine, PAR1-D39A, the Km and kcat were both reduced ~3-fold making the kcat/Km the same as PAR1-wt exodomain. Recombinant PAR4-wt exodomain was cleaved by ?-thrombin with a Km of 61 ?M, a kcat of 17 s-1 and kcat/Km of 2.8 ×105. When the P5 or P4 position was mutated to alanine PAR4-L43A or PAR4-P44A, respectively, there was no change in the Km (69 or 56 ?M, respectively) however; the kcat was lowered in each case (9.7 or 7.7 s-1, respectively). Mutation of the P2 position (PAR4-P46A) also had no effect on the Km but markedly lowered the kcat and kcat/Km ~35-fold. PAR1-wt exodomain and P4 and P3 mutants were noncompetitive inhibitors of ?-thrombin hydrolyzing Sar-Pro-Arg-pNA. However, PAR1-P40A displayed mixed type of inhibition. Mutation of P4, P3 or P2 had no effect on the Ki. All PAR4 exodomains were competitive inhibitors of ?-thrombin. Mutation of P5, P4 or P2 had no effect on the Ki. These investigations show that Leu at P4 in PAR1 or P5 in PAR4 critically influences the kinetics of ?-thrombin binding and cleavage of PAR1 and PAR4 exodomains. It also implies that factors other than the hirudin-like binding region on PAR1 exodomain predominate in influencing PAR1 cleavage on cells. PMID:17595115

  8. Par Pond vegetation status Summer 1995 -- Summary

    SciTech Connect

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned.

  9. Par Aziz EL TATAR Thse prsente

    E-print Network

    Paris-Sud XI, Université de

    les signaux après leur contamination par les artéfacts générés par les séquences d'imagerie. Il. We developed a device to allow a deep study of the contamination mechanism, which would assist, via an optical cable, the collected signal to a receiver box placed outside the MRI room. The receiver

  10. Irradiation Information

    NSDL National Science Digital Library

    The Food Safety Consortium (FSC) is a federally created consortium consisting of researchers from the University of Arkansas, Iowa State University and Kansas State University. The FSC conducts research in poultry, beef, and pork production. This site contains summary articles from the FDA, the Washington Times, the Los Angeles Times, the Chicago Tribune, and newsletter articles from the FSC. Previously approved for use on poultry and fruits and vegetables in the US, irradiation can kill disease-causing bacteria like Salmonella and Escherichia coli 0157:H7 (discussed in the Scout Report for Science and Engineering's In the News section, September 17, 1997), and molds and funguses that cause rot. With recent US Food and Drug Administration (FDA) approval, irradiation can now be used to process red meat (e.g., beef, pork, lamb, and byproducts). The process involves exposing food to a source of radiation such as gamma rays from radioactive cobalt 60, cesium 137, or x-rays. No radioactive material is added to the product, and the technique is routinely used on grains and spices, as well as for sterilizing disposable medical devices. In spite of a number of tests conducted over the last 30 years substantiating its safety, irradiation has not gained widespread public acceptance in the US. This is largely due to the public's general fear of processes utilizing radiation. Supporters of the technology claim that it will virtually eliminate food-borne illness in the US, while skeptics feel that technology such as steam treatment can accomplish adequate sterilization without the purported risks and public concern associated with irradiation.

  11. Enhancement effect of irradiation by methotrexate

    SciTech Connect

    Shehata, W.M.; Meyer, R.L.

    1980-09-15

    Three cases are described in which complications developed which were believed to be due to the enhancement effect of irradiation by methotrexate during the course of therapy for lung, kidney, and bladder cancer. These included esophageal and large bowel complications. In two of these cases, the patients improved with conservative therapy.

  12. Comparative analysis of a plant pseudoautosomal region (PAR) in Silene latifolia with the corresponding S. vulgaris autosome

    PubMed Central

    2012-01-01

    Background The sex chromosomes of Silene latifolia are heteromorphic as in mammals, with females being homogametic (XX) and males heterogametic (XY). While recombination occurs along the entire X chromosome in females, recombination between the X and Y chromosomes in males is restricted to the pseudoautosomal region (PAR). In the few mammals so far studied, PARs are often characterized by elevated recombination and mutation rates and high GC content compared with the rest of the genome. However, PARs have not been studied in plants until now. In this paper we report the construction of a BAC library for S. latifolia and the first analysis of a?>?100?kb fragment of a S. latifolia PAR that we compare to the homologous autosomal region in the closely related gynodioecious species S. vulgaris. Results Six new sex-linked genes were identified in the S. latifolia PAR, together with numerous transposable elements. The same genes were found on the S. vulgaris autosomal segment, with no enlargement of the predicted coding sequences in S. latifolia. Intergenic regions were on average 1.6 times longer in S. latifolia than in S. vulgaris, mainly as a consequence of the insertion of transposable elements. The GC content did not differ significantly between the PAR region in S. latifolia and the corresponding autosomal region in S. vulgaris. Conclusions Our results demonstrate the usefulness of the BAC library developed here for the analysis of plant sex chromosomes and indicate that the PAR in the evolutionarily young S. latifolia sex chromosomes has diverged from the corresponding autosomal region in the gynodioecious S. vulgaris mainly with respect to the insertion of transposable elements. Gene order between the PAR and autosomal region investigated is conserved, and the PAR does not have the high GC content observed in evolutionarily much older mammalian sex chromosomes. PMID:22681719

  13. AGirenPArTenAriAT despartenariats

    E-print Network

    la gestion des écosystèmes majeurs de la région1 . Le séminaire Les intérieurs du Maroc a par'Institut national de recherche halieutique au Maroc,l'Écolenationaled'ingénieursdeTunisoul'Institutnatio- nal

  14. Faits et phnomnes tudis par les OHM

    E-print Network

    van Tiggelen, Bart

    Faits et phénomènes étudiés par les OHM Anthropisation des écosystèmes.· Dynamiques de la biodiversité.· Dynamiques des pollutions et écotoxicologie.· Environnement et santé.· Modification des occupations humaines et impacts, résiliences· et ruptures, dégradations et réhabilitations. Adaptation aux

  15. Memoire de MASTER RECHERCHE presente par

    E-print Network

    Paris-Sud XI, Université de

    'augmentation de fr´equence allant de pair. Bien que la finesse de gravure continue de progresser, r´eduisant de composants, en utilisant notamment l'espace offert par une gravure plus fine pour ajou- ter des unit

  16. NOUVEAU SYSTME TLGRAPHIQUE; PAR M. ESTIENNE.

    E-print Network

    Paris-Sud XI, Université de

    conformément au code Morse. Le trait peut occuper, en hauteur, la largeur du ruban de papier, quelle que soit volume du Morse. L'avan- cement du papier se produit par un mécanisme analogue à celui de ce dernier

  17. Simulink/PARS Integration Support

    SciTech Connect

    Vacaliuc, B. [ORNL] [ORNL; Nakhaee, N. [Sundance DSP, Inc.] [Sundance DSP, Inc.

    2013-12-18

    The state of the art for signal processor hardware has far out-paced the development tools for placing applications on that hardware. In addition, signal processors are available in a variety of architectures, each uniquely capable of handling specific types of signal processing efficiently. With these processors becoming smaller and demanding less power, it has become possible to group multiple processors, a heterogeneous set of processors, into single systems. Different portions of the desired problem set can be assigned to different processor types as appropriate. As software development tools do not keep pace with these processors, especially when multiple processors of different types are used, a method is needed to enable software code portability among multiple processors and multiple types of processors along with their respective software environments. Sundance DSP, Inc. has developed a software toolkit called “PARS”, whose objective is to provide a framework that uses suites of tools provided by different vendors, along with modeling tools and a real time operating system, to build an application that spans different processor types. The software language used to express the behavior of the system is a very high level modeling language, “Simulink”, a MathWorks product. ORNL has used this toolkit to effectively implement several deliverables. This CRADA describes this collaboration between ORNL and Sundance DSP, Inc.

  18. Elevated CO2 alleviates high PAR and UV stress in the unicellular chlorophyte Dunaliella tertiolecta.

    PubMed

    García-Gómez, Candela; Gordillo, Francisco J L; Palma, Armando; Lorenzo, M Rosario; Segovia, María

    2014-09-01

    The effects of increased CO2 and irradiance on the physiological performance of the chlorophyte Dunaliella tertiolecta were studied at different PAR and UVR (UVA + UVB) irradiances, simulating the solar radiation at different depths, at present (390 ppmv, LC) and predicted CO2 levels for the year 2100 (1000 ppmv, HC). Elevated CO2 resulted in higher optimum and effective quantum yields (F(v)/F(m) and ?PSII, respectively), electron transport rates (ETR) and specific growth rates (?). Cell stress was alleviated in HC with respect to LC as evidenced by a decrease in reactive oxygen species (ROS) accumulation. DNA damage showed a 42-fold increase in cyclobutane-pyrimidine dimer (CPD) formation under the highest irradiance (1100 ?mol quanta m(-2) s(-1)) in LC with respect to the lowest irradiance (200 ?mol quanta m(-2) s(-1)). Photolyase (CII-PCD-PL) gene expression was upregulated under HC resulting in a drastic decrease in CPD accumulation to only 25% with respect to LC. Proliferating cell nuclear antigen (PCNA) accumulation was always higher in HC and the accumulation pattern indicated its involvement in repair or growth depending on the irradiance dose. The repressor of silencing (ROS1) was only marginally involved in the response, suggesting that photoreactivation was the most relevant mechanism to overcome UVR damage. Our results demonstrate that future scenarios of global change result in alleviation of irradiance stress by CO2-induced photoprotection in D. tertiolecta. PMID:25043601

  19. SUR UN NOUVEAU RHOSTAT; PAR M. CROVA.

    E-print Network

    Boyer, Edmond

    du rhéostat. Pour se servir à volonté d'un seul fil, et pour pouvoir les étudier séparément, on peut table de leurs résistances en divers points de lcur longueur. Enfin on peut encore se servir du rhéostat conducteur de résistance négligeable, et sort par la borne inférieure p. On peut se servir ainsi de trois

  20. Radioecological implications of the Par Pond drawdown

    SciTech Connect

    Hickey, H. [Westinghouse Savannah River Co., Aiken, SC (United States); Whicker, F.W. [Savannah River Ecology Lab., Aiken, SC (United States)

    1991-12-05

    The drawdown of the Par Pond reservoir created dramatic alterations in this formerly stable lentic ecosystem. In addition, the radiation environment at Par Pond has changed significantly because of the exposure of Cesium 137-contaminated sediments and the appearance of new transport pathways to the terrestrial environment. In response to this situation, SREL was asked to study the radioecological implications of the reservoir drawdown. This report contains the objectives, methods, and results of the SREL study.

  1. Céphalées par abus médicamenteux et addiction

    Microsoft Academic Search

    F. Radat; C. Creac'h; M. Lafitau; S. Irachabal; V. Dousset; P. Henry

    2005-01-01

    Résumé  \\u000a Objectifs: étude de la comorbidité pour les troubles liés à l’utilisation de substances psychoactives chez les patients souffrant de\\u000a céphalées par abus médicamenteux.Méthode: étude comparative de quarante et un migraineux (MIG) et quarante et un patients souffrant de céphalées par abus médicamenteux\\u000a issus de migraines (CAM).Résultats: les CAM ulilisant des médicaments contenant des substances psychoactives (caféine et codéine) remplissent

  2. Exploration de r eseaux par un robot

    E-print Network

    Ilcinkas, David

    Exploration de r â?? eseaux par un robot (Network exploration with a robot) P. Fraigniaud 1 , D Râ?? esumâ?? e. Cet article traite de l'exploration d'un râ??eseau par un agent mobile, ou robot, mod d'au plus K+1 noeuds que le robot ne râ??eussit pas â?? a explorer. Cette borne K+1 amâ??eliore toutes les

  3. Maladies émergentes transmises par les tiques

    Microsoft Academic Search

    Ingomar Mutz

    2009-01-01

    RésuméLes infections transmises par les tiques surviennent dans le monde entier et sont bien connues depuis plus d’un siècle. Certaines d’entre elles sont très courantes alors que d’autres sont extrêmement rares. Les techniques modernes de génétique moléculaire (dont une plus grande disponibilité de la réaction en chaîne par polymérase (PCR) (de l’anglais polymerase chain reaction) ont permis la découverte et

  4. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes

    PubMed Central

    Crespo, Carolina Lage; Vernieri, Claudio; Keller, Philipp J.; Garrè, Massimiliano; Bender, Jeffrey R.; Wittbrodt, Joachim; Pardi, Ruggero

    2014-01-01

    ABSTRACT Inflammatory cells acquire a polarized phenotype to migrate towards sites of infection or injury. A conserved polarity complex comprising PAR-3, PAR-6 and atypical protein kinase C (aPKC) relays extracellular polarizing cues to control cytoskeletal and signaling networks affecting morphological and functional polarization. However, there is no evidence that myeloid cells use PAR signaling to migrate vectorially in three-dimensional (3D) environments in vivo. Using genetically encoded bioprobes and high-resolution live imaging, we reveal the existence of F-actin oscillations in the trailing edge and constant repositioning of the microtubule organizing center (MTOC) to direct leukocyte migration in wounded medaka fish larvae (Oryzias latipes). Genetic manipulation in live myeloid cells demonstrates that the catalytic activity of aPKC and the regulated interaction with PAR-3 and PAR-6 are required for consistent F-actin oscillations, MTOC perinuclear mobility, aPKC repositioning and wound-directed migration upstream of Rho kinase (also known as ROCK or ROK) activation. We propose that the PAR complex coordinately controls cytoskeletal changes affecting both the generation of traction force and the directionality of leukocyte migration to sites of injury. PMID:25179599

  5. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

    PubMed

    Crespo, Carolina Lage; Vernieri, Claudio; Keller, Philipp J; Garrè, Massimiliano; Bender, Jeffrey R; Wittbrodt, Joachim; Pardi, Ruggero

    2014-10-15

    Inflammatory cells acquire a polarized phenotype to migrate towards sites of infection or injury. A conserved polarity complex comprising PAR-3, PAR-6 and atypical protein kinase C (aPKC) relays extracellular polarizing cues to control cytoskeletal and signaling networks affecting morphological and functional polarization. However, there is no evidence that myeloid cells use PAR signaling to migrate vectorially in three-dimensional (3D) environments in vivo. Using genetically encoded bioprobes and high-resolution live imaging, we reveal the existence of F-actin oscillations in the trailing edge and constant repositioning of the microtubule organizing center (MTOC) to direct leukocyte migration in wounded medaka fish larvae (Oryzias latipes). Genetic manipulation in live myeloid cells demonstrates that the catalytic activity of aPKC and the regulated interaction with PAR-3 and PAR-6 are required for consistent F-actin oscillations, MTOC perinuclear mobility, aPKC repositioning and wound-directed migration upstream of Rho kinase (also known as ROCK or ROK) activation. We propose that the PAR complex coordinately controls cytoskeletal changes affecting both the generation of traction force and the directionality of leukocyte migration to sites of injury. PMID:25179599

  6. Safer Food with Irradiation 

    E-print Network

    Thompson, Britta; Vestal, Andy; Van Laanen, Peggy

    2003-01-21

    This publication answers questions about food irradiation and how it helps prevent foodborne illnesses. Included are explanations of how irradiation works and its benefits. Irradiation is a safe method of preserving food quality and ensuring its...

  7. Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets

    PubMed Central

    Duvernay, Matthew; Young, Summer; Gailani, David; Schoenecker, Jonathan

    2013-01-01

    With the recent interest of protease-activated receptors (PAR) 1 and PAR4 as possible targets for the treatment of thrombotic disorders, we compared the efficacy of protease-activated receptor (PAR)1 and PAR4 in the generation of procoagulant phenotypes on platelet membranes. PAR4-activating peptide (AP)–stimulated platelets promoted thrombin generation in plasma up to 5 minutes earlier than PAR1-AP–stimulated platelets. PAR4-AP–mediated factor V (FV) association with the platelet surface was 1.6-fold greater than for PAR1-AP. Moreover, PAR4 stimulation resulted in a 3-fold greater release of microparticles, compared with PAR1 stimulation. More robust FV secretion and microparticle generation with PAR4-AP was attributable to stronger and more sustained phosphorylation of myosin light chain at serine 19 and threonine 18. Inhibition of Rho-kinase reduced PAR4-AP–mediated FV secretion and microparticle generation to PAR1-AP–mediated levels. Thrombin generation assays measuring prothrombinase complex activity demonstrated 1.5-fold higher peak thrombin levels on PAR4-AP–stimulated platelets, compared with PAR1-AP–stimulated platelets. Rho-kinase inhibition reduced PAR4-AP–mediated peak thrombin generation by 25% but had no significant effect on PAR1-AP–mediated thrombin generation. In conclusion, stimulation of PAR4 on platelets leads to faster and more robust thrombin generation, compared with PAR1 stimulation. The greater procoagulant potential is related to more efficient FV release from intracellular stores and microparticle production driven by stronger and more sustained myosin light chain phosphorylation. These data have implications about the role of PAR4 during hemostasis and are clinically relevant in light of recent efforts to develop PAR antagonists to treat thrombotic disorders. PMID:23307185

  8. Etude du vieillissement de la glace Ih par mesures de frottement interne et par observation en topographie aux rayons X

    E-print Network

    Paris-Sud XI, Université de

    1473 Etude du vieillissement de la glace Ih par mesures de frottement interne et par observation en par mesures de frottement interne et par des observations en topographie aux rayons X. Ces mesures défauts de réseau. En effet, nos études antérieures [11, 14, 17] portant sur le frottement interne de la

  9. Conservation Focus and Executive

    E-print Network

    Northwest Power and Conservation Council Focus and Executive Summary Background Power Committee Walla Walla May 12, 2009 #12;Northwest Power and Conservation Council Conditions Facing the Region and Conservation Council Resource Alternatives · Increased cost-effective efficiency potential ­ Technological

  10. MODEL CONSERVATION STANDARD INTRODUCTION

    E-print Network

    MODEL CONSERVATION STANDARD INTRODUCTION As directed by the Northwest Power Act, the Council has designed model conservation standards to produce all electricity savings that are cost believes the measures used to achieve the model conservation standards should provide reliable savings

  11. Water conservation programs

    SciTech Connect

    Darilek, A. [New Mexico State Engineer Office, Santa Fe, NM (United States). Water Conservation Program; Witherspoon, J. [City of Albuquerque, NM (United States). Public Works Dept.; Hutchinson, D.L. [Intel Corp., Rio Rancho, NM (United States)

    1995-12-31

    The paper discusses three water conservation programs: statewide water conservation efforts, a 5-point program of the City of Albuquerque, and the program for recycling wastewater by the Intel Corporation. Water conservation programs depend largely on public education programs. Albuquerque`s program, for example, includes development of a K-12th grade curriculum on water conservation, live theater performances promoting conservation for elementary school children, and collaboration with existing community organizations to promote water conservation.

  12. CFIP2006-POSTPRINT Prdiction de mobilit par le mobile ou par

    E-print Network

    Paris-Sud XI, Université de

    as guessing a mobile node's next access point as it moves through a wireless network. Those predictions help garantie de qualité de service (QoS) minimale. Lorsqu'un terminal mobile se déplace, une des causesCFIP2006-POSTPRINT Prédiction de mobilité par le mobile ou par le point d'accès : comparaison sur

  13. L'ABSORPTION DES ULTRASONS PAR CERTAINES CTONES Par S. PARTHASARATHY et V. NARASIMHAN,

    E-print Network

    Paris-Sud XI, Université de

    957. L'ABSORPTION DES ULTRASONS PAR CERTAINES CÉTONES Par S. PARTHASARATHY et V. NARASIMHAN coefficient d'absorption ont été mesurés dans plusieurs cétones à différentes températures et les résultats variation de l'absorption avec la température était positif dans l'intervalle considéré dans ce travail

  14. MRI Asymmetries of Broca's Area: The Pars Triangularis and Pars Opercularis

    Microsoft Academic Search

    Anne L. Foundas; Kathy F. Eure; Laura F. Luevano; Daniel R. Weinberger

    1998-01-01

    Broca's area, which includes the pars triangularis (PTR) and pars opercularis (POP), is a neuroanatomic region important in speech-language production. Previous data demonstrated that PTR asymmetries are highly correlated with language dominance determined by selective hemispheric anesthesia or Wada testing, suggesting that asymmetries of the PTR may, in part, predict language dominance. The POP, however, has not been measured on

  15. PREVENTIVE CONSERVATION: A CONCEPT SUITED TO THE CONSERVATION OF EARTHEN

    E-print Network

    Paris-Sud XI, Université de

    PREVENTIVE CONSERVATION: A CONCEPT SUITED TO THE CONSERVATION OF EARTHEN ARCHITECTURAL HERITAGE and Construction Key words: Preventive conservation, traditional conservation practices, risk reduction, heritage management Abstract The concept of "preventive conservation" is relatively old as it has already been

  16. Use of Irradiated Foods

    NASA Technical Reports Server (NTRS)

    Brynjolfsson, A.

    1985-01-01

    The safety of irradiated foods is reviewed. Guidelines and regulations for processing irradiated foods are considered. The radiolytic products formed in food when it is irradiated and its wholesomeness is discussed. It is concluded that food irradiation processing is not a panacea for all problems in food processing but when properly used will serve the space station well.

  17. Industrial energy conservation technology

    Microsoft Academic Search

    1983-01-01

    This book presents the papers given at a conference which examined energy conservation in industrial plants. Topics considered at the conference included the economics of cogeneration, energy conservation techniques, heat recovery systems, energy retrofits, energy management systems in buildings, energy conservation in the textile industry, energy conservation in the telecommunications industry, alternative energy sources, efficient techniques for heating and cooling

  18. December 9, 2008 Conservation

    E-print Network

    1 December 9, 2008 Northwest Power and Conservation Council Northwest Power and Conservation Council Sixth Northwest Conservation & Electric Power Plan Rankine-cycle Coal-fired Power Plant Resource Assessment Jeff King Northwest Power and Conservation Council Generating Resources Advisory Committee

  19. LAND & WATER CONSERVATION PROGRAM

    E-print Network

    New Hampshire, University of

    and resources in a geographic area Promote conservation of these natural features and resources Guide ________________________________________________________________________ Preparing a Conservation Plan INTRODUCTION Conservation of land, water and other natural features and resources is a priority for many New Hampshire communities. In order to implement conservation projects

  20. Non-convex entropies for conservation laws with involutions.

    PubMed

    Dafermos, Constantine M

    2013-12-28

    The paper discusses systems of conservation laws endowed with involutions and contingent entropies. Under the assumption that the contingent entropy function is convex merely in the direction of a cone in state space, associated with the involution, it is shown that the Cauchy problem is locally well posed in the class of classical solutions, and that classical solutions are unique and stable even within the broader class of weak solutions that satisfy an entropy inequality. This is on a par with the classical theory of solutions to hyperbolic systems of conservation laws endowed with a convex entropy. The equations of elastodynamics provide the prototypical example for the above setting. PMID:24249772

  1. Conservation and drought management

    E-print Network

    Finch, Calvin

    2012-01-01

    Fall 2012 tx H2O 5 Column by Dr. Calvin Finch, Water Conservation and Technology Center director Conservation and Drought Management WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future Water conservation and drought... management are related, but they are not the same. Water conservation is a long-term e#27;ort to reduce the amount of water it takes to manufacture goods, manage households and care for landscapes. Drought management is water-use rules initiated to deal...

  2. Conservation and drought management 

    E-print Network

    Finch, Calvin

    2012-01-01

    Fall 2012 tx H2O 5 Column by Dr. Calvin Finch, Water Conservation and Technology Center director Conservation and Drought Management WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future Water conservation and drought... management are related, but they are not the same. Water conservation is a long-term e#27;ort to reduce the amount of water it takes to manufacture goods, manage households and care for landscapes. Drought management is water-use rules initiated to deal...

  3. Frottement interne dans le zirconium irradie aux neutrons A 77 K

    Microsoft Academic Search

    R. Pichon; E. Bisognis; P. Mosek

    1973-01-01

    Le zirconium présente après irradiation neutronique à 77 K sept pics de frottement interne. Les deux premiers correspondent à la réorientation complexe de ?interstitiel libre migrant à trois dimensions en fin de stade I. Le dipole élastique créé par cet interstitiel est monoclinique et sa réorientation complexe donne lieu à un pic dissocié conforme aux prévisions de Nowick. Ce défaut

  4. Frottement interne dans le titane irradie ou ecroui A 77 K

    Microsoft Academic Search

    R. Pichon; E. Bisocni; P. Moser

    1974-01-01

    Après irradiation neutronique à 77 K, le titane présente quatre pics de frottement interne. Le premier, et un composant du second, correspondent à la rdorientation d'un interstitiel monoclinique disparaissant en fin de stade I par migration tridimensionnelle.Après écrouissage à tempirature ambiante, le titane employé préente un pic B 140 K analogue à celui que R. R. Hasiguti avait obscrvé. Ce

  5. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    SciTech Connect

    Kinney, Kathryn A [ORNL

    2009-10-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ({sup 252}Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for {sup 252}Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for {sup 252}Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and reliable Par manipulator arm is necessary for uninterrupted {sup 252}Cf operations; a fully-functioning bridge is needed for the system to function as intended.

  6. Kallikrein 6 Signals through PAR1 and PAR2 to Promote Neuron Injury and Exacerbate Glutamate Neurotoxicity

    PubMed Central

    Yoon, Hyesook; Radulovic, Maja; Wu, Jianmin; Blaber, Sachiko I.; Blaber, Michael; Fehlings, Michael G.; Scarisbrick, Isobel A.

    2014-01-01

    CNS trauma generates a proteolytic imbalance contributing to secondary injury, including axonopathy and neuron degeneration. Kallikrein 6 (Klk6) is a serine protease implicated in neurodegeneration and here we investigate the role of protease activated receptors 1 (PAR1) and PAR2 in mediating these effects. First we demonstrate Klk6 and the prototypical activator of PAR1, thrombin, as well as PAR1 and PAR2, are each elevated in murine experimental traumatic spinal cord injury (SCI) at acute or subacute time points. Recombinant Klk6 triggered ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line, in a PI3K and MEK-dependent fashion. Importantly, lipopeptide inhibitors of PAR1 or PAR2, and PAR1 genetic deletion, each reduced Klk6-ERK1/2 activation. In addition, Klk6 and thrombin promoted degeneration of cerebellar neurons and exacerbated glutamate neurotoxicity. Moreover, genetic deletion of PAR1 blocked thrombin-mediated cerebellar neurotoxicity and reduced the neurotoxic effects of Klk6. Klk6 also increased glutamate-mediated Bim signaling, PARP cleavage and lactate dehydrogenase (LDH) release in NSC34 motoneurons and these effects were blocked by PAR1 and PAR2 lipopeptide inhibitors. Taken together these data point to a novel Klk6-signaling axis in CNS neurons that is mediated by PAR1 and PAR2 and is positioned to contribute to neurodegeneration. PMID:23647384

  7. CDK-1 and Two B-Type Cyclins Promote PAR-6 Stabilization during Polarization of the Early C. elegans Embryo

    PubMed Central

    Rabilotta, Alexia; Desrosiers, Marianne; Labbé, Jean-Claude

    2015-01-01

    In the C. elegans embryo, formation of an antero-posterior axis of polarity relies on signaling by the conserved PAR proteins, which localize asymmetrically in two mutually exclusive groups at the embryonic cortex. Depletion of any PAR protein causes a loss of polarity and embryonic lethality. A genome-wide RNAi screen previously identified two B-type cyclins, cyb-2.1 and cyb-2.2, as suppressors of par-2(it5ts) lethality. We found that the loss of cyb-2.1 or cyb-2.2 suppressed the lethality and polarity defects of par-2(it5ts) mutants and that these cyclins act in cell polarity with their cyclin-dependent kinase partner, CDK-1. Interestingly, cyb-2.1; cyb-2.2 double mutants did not show defects in cell cycle progression or timing of polarity establishment, suggesting that they regulate polarity independently of their typical role in cell cycle progression. Loss of both cyclin genes or of cdk-1 resulted in a decrease in PAR-6 levels in the embryo. Furthermore, the activity of the cullin CUL-2 was required to achieve suppression of par-2 lethality when both cyclins were absent. Our results support a model in which CYB-2.1/2/CDK-1 antagonize CUL-2 activity to promote stabilization of PAR-6 levels during polarization of the early C. elegans embryo. They also suggest that CYB-2.1 and CYB-2.2 contribute to the coupling of cell cycle progression and asymmetric segregation of cell fate determinants. PMID:25658117

  8. Imagerie Resolue dans le Temps des Photons et Neutres Metastables Emis D'une Surface Par Stimulation Electronique

    Microsoft Academic Search

    Gregoire Leclerc

    1992-01-01

    L'appareil que nous presentons ici a ete mis au point pour permettre d'accumuler des images numeriques, resolues dans le temps, de la desorption par stimulation electronique (DSE) d'ions positifs et negatifs, de photons et de neutres metastables, tout en conservant des capacites de base de diffraction d'electrons lents (DEL) et de transmission d'electrons lents (TEL). Le spectrometre comporte un monochromateur

  9. The African Conservation Foundation

    NSDL National Science Digital Library

    Terry Harnwell

    2001-08-15

    This portal provides in-depth information about conservation issues and initiatives in Africa. The online searchable databases and forums showcase, promote and provide background information on almost 300 conservation organisations and protected area institutions across the continent. The African Conservation Foundation (ACF) is primarily concerned with education and capacity building in Africa in the areas of environment and conservation. Its mission is to support and link African conservation initiatives, groups and NGOs, with the aim of strengthening their capacity, building partnerships and promoting effective communication and co-ordination of conservation efforts.

  10. Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions.

    PubMed

    Luo, Yan; Fukuhara, Masayuki; Weitzman, Matthew; Rizzolo, Lawrence J

    2006-09-19

    The tight junctions of the endothelial and epithelial regions of the blood-brain barrier are regulated by interactions with the neighboring tissue. We examined how the neural retina regulates the assembly of tight junctions in the retinal pigment epithelium (RPE). The proteins JAM-A, AF-6, PAR-3 and PAR-6 have been implicated in the assembly of other epithelial tight junctions. Using chick embryos and primary cell culture, we examined gene expression of these proteins during embryonic development, and whether retinal secretions regulate their expression. Three highly conserved RNA splice sites of AF-6 were identified in chick ocular tissues, but only two were expressed in RPE. JAM-A and AF-6 were expressed at relatively high levels early in development when adherens junctions form, but before tight junctions form. Expression of JAM-A and the AF-6 isoforms actually decreased when tight junctions were forming and expanding. The expression of PAR-3 and PAR-6 was constant. Despite the expression of these proteins in vitro (along with claudins, occludin, ZO-1 and ZO-2), the tight junctional networks that form were discontinuous (Rahner, C., Fukuhara, M., Peng, S., Kojima, S., Rizzolo, L.J., 2004. The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. J. Cell Sci. 117, 3307-3318). The expression of these assembly proteins was unaffected by a retinal conditioned medium that induced the completion of tight junction formation. These data indicate that the early expression of the assembly proteins corresponds to the initial establishment of the adherens and tight junctions, but secretory products of the neural retina must induce the expression of additional proteins to complete the maturation process. PMID:16859655

  11. Parasitology http://journals.cambridge.org/PAR

    E-print Network

    Schnaufer, Achim

    Parasitology http://journals.cambridge.org/PAR Additional services for Parasitology: Email alerts Parasitology / Volume 139 / Special Issue 09 / August 2012, pp 1168 1177 DOI: 10.1017/S0031182012000443 brucei cytoskeleton: advances and opportunities. Parasitology, 139, pp 11681177 doi:10.1017/S

  12. Parasitology http://journals.cambridge.org/PAR

    E-print Network

    Paris-Sud XI, Université de

    Parasitology http://journals.cambridge.org/PAR Additional services for Parasitology: Email alerts. BELTRAN, R. POULIN and C. LAGRUE Parasitology / FirstView Article / October 2012, pp 1 9 DOI: 10.1017/S parvum (Trematoda) life history strategy, size and egg production. Parasitology, Available on CJO doi:10

  13. Prsent par Leonardo-Geo MANESCU

    E-print Network

    Paris-Sud XI, Université de

    THÈSE Présenté par Leonardo-Geo MANESCU Ingénieur de l'Université de Craiova / ROUMANIE Pour obtenir le titre de DOCTEUR de l'INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE et de l'UNIVERSITÉ DE CRAIOVA Laboratoire d'Électotechnique de Grenoble et de la Faculté d'Électrotechnique de l'Université de Craiova tel

  14. 235 -2010 Anne : 2010 Dlivre par

    E-print Network

    Sandrine ISOARD-GAUTHEUR LE BURNOUT SPORTIF CHEZ DES ADOLESCENTS(TES) EN POLE ESPOIR HANDBALL : APPROCHE tel-00842944,version1-9Jul2013 #12;Le Burnout Sportif chez des Adolescents(tes) en Pôle Espoir premier chapitre présente une revue de littérature sur le burnout sportif. Par la suite trois axes de

  15. Intramural Sports Par 3 Golf League

    E-print Network

    Escher, Christine

    Intramural Sports Par 3 Golf League Summer 2014 Intramural Sports Calendar of Events Summer 2014 Sports and Special Programs Office 111 Dixon Recreation Center (541)737-4083 Summer Office Hours: 1:00pm to 4:00pm M-F http://oregonstate.edu/recsports/intramural-sports Oregon State University

  16. suPAR and Team Nephrology

    PubMed Central

    2014-01-01

    Primary focal segmental glomerulosclerosis (FSGS) accounts for nearly 10 % of patients who require renal replacement therapy. Elevated circulating levels of soluble urokinase receptor (suPAR) have been identified as a biomarker to discriminate primary FSGS from other glomerulopathies. Subsequent reports have questioned the diagnostic utility of this test. In a study in BMC Medicine, Huang et al. demonstrate that urinary soluble urokinase receptor (suPAR) excretion assists in distinguishing primary FSGS from other glomerular diseases, and that high plasma suPAR concentrations are not directly linked to a decline in glomerular filtration rate (GFR). This observation suggests that further investigation of suPAR is warranted in patients with FSGS. It should be interpreted in light of a recent report that B7-1 is expressed in the podocytes of a subset of patients with FSGS, and that blocking this molecule may represent the first successful targeted intervention for this disease. These advances highlight the rapid pace of scientific progress in the field of nephrology. Nephrologists should work together, share resources, and expedite the design of protocols to evaluate these novel biomarkers in a comprehensive and scientifically valid manner. Please see related article http://www.biomedcentral.com/1741-7015/12/81. PMID:24885021

  17. Recherche dirigée par le dernier conflit

    Microsoft Academic Search

    Christophe Lecoutre; Lakhdar Sais; Sébastien Tabary; Vincent Vidal

    2006-01-01

    In this paper, we propose an approach to guide search to sources of conflicts. The principle is the fol- lowing: the last variable involved in the last conflict is selected in priority, as long as the constraint net- work can not be made consistent, in order to find the (most recent) culprit variable, following the current par- tial instantiation from

  18. Prsente par Pour obtenir le grade de

    E-print Network

    Paris-Sud XI, Université de

    Présentée par !" # $ Pour obtenir le grade de %&'"()"*& + , Apprentissage autonome de réseaux de neurones pour le pilotage en temps réel des systèmes de production basé sur l'optimisation via simulation, auront contribué à ce grand effort car, si l'épreuve est individuelle, ses implications sont sociales

  19. Conservation potential of agricultural water conservation subsidies

    Microsoft Academic Search

    Ray Huffaker

    2008-01-01

    A current policy subsidizes farmers to invest in improved on-farm irrigation efficiency, expecting water to be conserved off farm. Contrary to expectation, water has been increasingly depleted in some regions after such improvements. This paper investigates the policy's failure to conserve water consistently by (1) formulating an economic model of irrigated crop production to determine a profit-maximizing irrigator's range of

  20. Natural Resources Conservation Service: Backyard Conservation

    NSDL National Science Digital Library

    The Natural Resources Conservation Service, a division of the U.S. Department of Agriculture, has a feature on their website on backyard conservation. Conservation practices used on agricultural land throughout the country have been adapted for the smaller scale of backyards. Not only can visitors download and print out a 28-page booklet in English or Spanish, but they can also download and print out eight tip sheets on backyard conservation. Information on how to order the free above-mentioned material, through the mail, is also provided. Using the link in the middle of the page, "See More Tips and Topics on Backyard Conservation", visitors can read over 30 archived tips and topics, including "Invite a Toad to Dinner", "Selecting the Right Tree", and "Dream Yard". For teachers, the link "Backyard Conservation Lesson Plans" in the middle of the page provides a variety of lesson plans. Some of the lessons included are "Team Flight", which is about birds; "Growing Native", which is about native plant communities; and "Backyard Conservation and Local Laws", which is about how community laws may help or hinder backyard conservation efforts. A mock city council hearing is the final activity of the lesson.

  1. INFLUENCE DE L'IMMUNIT PASSIVE TRANSMISE PAR LE COLOSTRUM

    E-print Network

    Paris-Sud XI, Université de

    INFLUENCE DE L'IMMUNITÉ PASSIVE TRANSMISE PAR LE COLOSTRUM SUR L'ÉVOLUTION DE LA PESTE PORCINE transmise par le colostrum a permis de mettre en évidence chez r8 porcelets, de 20 à 25 kg, issus de truies transmise par le colostrum. Les applications qu'entraînent ces observations font l'objet de la discussion

  2. Rdig par Imane Hammouali Anne Scolaire 2009/2010 1

    E-print Network

    Sart, Remi

    Rédigé par Imane Hammouali Année Scolaire 2009/2010 1 Laboratoire de Météorologie Physique (La-parallèle homogène Réalisé par : Imane Hammouali Tuteurs de stage: Mr. Frédéric Szczap (LaMP) -Mr. Thierry Faure 31 Juillet 2010 #12;Rédigé par Imane Hammouali Année Scolaire 2009/2010 2 Remerciements Je tiens à

  3. Asservissement par PID Application du PWM au pont en H

    E-print Network

    Tardieu, Samuel

    Plan Asservissement par PID PWM Ponts en H Application du PWM au pont en H Bibliographie Asservissement par PID, PWM et Ponts en H Siwar, Cédric, Samuel Télécom Paristech 4 mars 2011 Siwar, Cédric, Samuel ROSE 1 / 33 4 mars 2011 #12;Plan Asservissement par PID PWM Ponts en H Application du PWM au pont

  4. Contrle de drones et robots par reconnaissance de mouvements complexes

    E-print Network

    Boyer, Edmond

    Contrôle de drones et robots par reconnaissance de mouvements complexes Anaïs Finzi, Bastien Tauran contexte du pilotage de drones et de robots par des mouvements de l'opérateur détectés par des applied to complex gesture recognition in the context of drones and robots control, when the human

  5. Amlioration de l'utilisation par les bovins des chaumes de Sorghum bicolor par le hachage et la complmentation

    E-print Network

    Boyer, Edmond

    Amélioration de l'utilisation par les bovins des chaumes de Sorghum bicolor par le hachage et la and Leng, 1986 ILCA/Addis Ababa). Un essai d'amélioration de pailles de Sorghum bicolor complémenté à l

  6. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain

    PubMed Central

    Kouzoukas, Dimitrios E.; Meyer-Siegler, Katherine L.; Ma, Fei; Westlund, Karin N.; Hunt, David E.; Vera, Pedro L.

    2015-01-01

    Introduction Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PAR1 or PAR4 receptors elicits release of urothelial MIF that acts on MIF receptors in the urothelium to mediate bladder inflammation and pain. Thus, we examined the effect of activation of specific bladder PAR receptors on MIF release, bladder pain, micturition and histological changes. Methods MIF release was measured in vitro after exposing immortalized human urothelial cells (UROtsa) to PAR1 or PAR4 activating peptides (AP). Female C57BL/6 mice received intravesical PAR1- or PAR4-AP for one hour to determine: 1) bladder MIF release in vivo within one hour; 2) abdominal hypersensitivity (allodynia) to von Frey filament stimulation 24 hours after treatment; 3) micturition parameters 24 hours after treatment; 4) histological changes in the bladder as a result of treatment; 5) changes in expression of bladder MIF and MIF receptors using real-time RT-PCR; 6) changes in urothelial MIF and MIF receptor, CXCR4, protein levels using quantitative immunofluorescence; 7) effect of MIF or CXCR4 antagonism. Results PAR1- or PAR4-AP triggered MIF release from both human urothelial cells in vitro and mouse urothelium in vivo. Twenty-four hours after intravesical PAR1- or PAR4-AP, we observed abdominal hypersensitivity in mice without changes in micturition or bladder histology. PAR4-AP was more effective and also increased expression of bladder MIF and urothelium MIF receptor, CXCR4. Bladder CXCR4 localized to the urothelium. Antagonizing MIF with ISO-1 eliminated PAR4- and reduced PAR1-induced hypersensitivity, while antagonizing CXCR4 with AMD3100 only partially prevented PAR4-induced hypersensitivity. Conclusions Bladder PAR activation elicits urothelial MIF release and urothelial MIF receptor signaling at least partly through CXCR4 to result in abdominal hypersensitivity without overt bladder inflammation. PAR-induced bladder pain may represent an interesting pre-clinical model of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) where pain occurs without apparent bladder injury or pathology. MIF is potentially a novel therapeutic target for bladder pain in IC/PBS patients. PMID:26020638

  7. Involvement of gibberellins in the stem elongation of sun and shade ecotypes of Stellaria longipes that is induced by low light irradiance.

    PubMed

    Kurepin, Leonid V; Pharis, Richard P; Reid, David M; Chinnappa, C C

    2006-07-01

    Plants from two ecotypes of Stellaria longipes, alpine (an open, sunny habitat) and prairie (where adjacent plants provide a shaded habitat), were grown under normal and reduced levels of photosynthetically active radiation (PAR). Growth under low PAR is significantly promoted in both ecotypes. When quantified by the stable isotope dilution method, endogenous gibberellins (GAs) (GA1, GA8, GA20, GA19) were significantly elevated under low PAR in both 'sun' and 'shade' ecotypes, as was GA53 in the shade ecotype. Changes in endogenous GA1 levels were significantly correlated with stem growth during a 28 d growth cycle and with relative growth rate (RGR) for height under low PAR for both ecotypes. Interestingly, under low irradiance PAR, changes (both increases and decreases) in GA8, the 2beta-hydroxylated 'inactive' catabolite of GA1, closely parallel bidaily stem growth changes for both ecotypes. Because the significantly greater stem elongation of both ecotypes in response to low irradiance PAR is associated with significant increases in the endogenous levels of five GAs (GA53, GA19, GA1, GA8) in the early 13-hydroxylation GA biosynthesis pathway (measured at days 7,14 and 21), we conclude that the low irradiance PAR has very likely induced an overall increase in GA biosynthesis. PMID:17080953

  8. Helicobacter pylori CagA Inhibits PAR1-MARK Family Kinases by Mimicking Host Substrates

    SciTech Connect

    Nesic, D.; Miller, M; Quinkert, Z; Stein, M; Chait, B; Stebbins, C

    2010-01-01

    The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2.

  9. The Conservator's Studio

    NSDL National Science Digital Library

    Seattle Art Museum

    Produced by the Seattle Art Museum, this online resource explores the Art Conservator's profession, showing you 4 paintings through a conservator's eyes. The exhibit begins with an overview of the profession.

  10. Conservation March 23, 2009

    E-print Network

    program information, technical sources, market information, and case studies on industrial energy Northwest Power Conservation Council and M a March 23, 2009 System ................................................................................................................................8 #12;March 23, 2009 Page 1 of 8 Introduction The Northwest Power and Conservation Council

  11. THORIE DE LA CAPTURE SLECTIVE DES NEUTRONS LENTS PAR CERTAINS NOYAUX Par FRANCIS PETRIN et WALTER M. ELSASSER.

    E-print Network

    Boyer, Edmond

    THÉORIE DE LA CAPTURE SÉLECTIVE DES NEUTRONS LENTS PAR CERTAINS NOYAUX Par FRANCIS PETRIN et WALTER neutrons lents observées pour quelques éléments par Fermi (plus de mille fois la section nucléaire), sans supposer d'action à distance entre les neutrons et les noyaux (1). Pour une interaction limitée au domaine

  12. Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types

    E-print Network

    Ahringe, Julie

    Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types David P kinase C (aPKC) plays a central role in cell polarisation. The small G protein Cdc42 also functions, it is not yet known whether Cdc42 and the Par3 complex widely function together in development or whether

  13. Critical Role for PAR1 in Kallikrein 6-Mediated Oligodendrogliopathy

    PubMed Central

    Burda, Joshua E.; Radulovic, Maja; Yoon, Hyesook; Scarisbrick, Isobel A.

    2014-01-01

    Kallikrein 6 (Klk6) is a secreted serine protease preferentially expressed by oligodendroglia in CNS white matter. Elevated levels of Klk6 occur in actively demyelinating multiple sclerosis (MS) lesions and in cases of spinal cord injury (SCI), stroke and glioblastoma. Taken with recent evidence establishing Klk6 as a CNS-endogenous activator of protease-activated receptors (PARs), we hypothesized that Klk6 activates a subset of PARs to regulate oligodendrocyte physiology and potentially pathophysiology. Here, primary oligodendrocyte cultures derived from wild type or PAR1-deficient mice and the murine oligodendrocyte cell line, Oli-neu, were used to demonstrate that Klk6 mediates loss of oligodendrocyte processes and impedes morphological differentiation of oligodendrocyte progenitor cells (OPCs) in a PAR1-dependent fashion. Comparable gliopathy was also elicited by the canonical PAR1 agonist, thrombin, as well as PAR1-activating peptides (PAR1-APs). Klk6 also exacerbated ATP-mediated oligodendrogliopathy in vitro, pointing to a potential role in augmenting excitotoxicity. In addition, Klk6 suppressed the expression of proteolipid protein (PLP) RNA in cultured oligodendrocytes by a mechanism involving PAR1-mediated Erk1/2 signaling. Microinjection of PAR1 agonists, including Klk6 or PAR1-APs, into the dorsal column white matter of PAR+/+ but not PAR?/? mice promoted vacuolating myelopathy and a loss of immunoreactivity for myelin basic protein (MBP) and CC-1+ oligodendrocytes. These results demonstrate a functional role for Klk6-PAR1 signaling in oligodendroglial pathophysiology and suggest that PAR1 or PAR1-agonists may represent new targets to moderate demyelination and to promote myelin regeneration in cases of CNS white matter injury or disease. PMID:23832758

  14. The Ocean Conservancy

    NSDL National Science Digital Library

    Learn about the Ocean Conservancy's conservation projects, the latest news in marine conservation, how to get involved, and more. Read over the current issues the Ocean Conservancy is working on, such as by catch, invasive species, and overfishing. Explore the "Fish and Wildlife" link for pictures and information on threatened and endangered animals; and read past and current issues of Blue Planet Magazine, OC's quarterly publication.

  15. Technology in water conservation

    E-print Network

    Finch, Dr. Calvin

    2013-01-01

    2 tx H2O Summer 2013 Column by Dr. Calvin Finch, Water Conservation and Technology Center director WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future It is not unusual for individuals to describe water conservation as a... through water conservation, introduction of new technology does not automati- cally result in water savings. #27;e new evapotrans- piration-based irrigation controllers illustrate the point. A lawn?s need for water is dependent on the weather...

  16. Nasopharyngeal Radium Irradiation (NRI)

    MedlinePLUS

    ... CDC to assess the health risks associated with nasopharyngeal radium irradiation. This treatment was an accepted medical ... a workshop on "The Public Health Response to Nasopharyngeal Radium Irradiation." It brought together a diverse group ...

  17. Conservation Overview of Draft

    E-print Network

    1 Northwest Power and Conservation Council Overview of Draft Sixth Power Plan Power Committee Web Conference May 19, 2009 Northwest Power and Conservation Council Conditions Facing the Region · Slower demand of variable resources · Uncertain, but likely, carbon control policies #12;2 Northwest Power and Conservation

  18. Multispecies Conservation Planning

    E-print Network

    CHAPTER 3 Multispecies Conservation Planning on U.S. Federal Lands Barry R. Noon, Kevin S. McKelvey, and Brett G. Dickson Numerous laws directly, or indirectly, mandate the conservation of all species that govern the use of these same lands that are in conflict with a goal of maximizing the conservation

  19. Introduction to Conservation Genetics

    Microsoft Academic Search

    R. Frankham; J. D. Ballou; D. A. Briscoe; Alec R. Lindsay

    2002-01-01

    Introduction to Conservation Genetics written by R. Frankham, J.D. Ballou, and D.A. Briscoe, is a comprehensive introductory text that provides an enlightening synthesis of data and theory from ecology, population genetics, evolution, and conservation biology. The book focuses on the science of conservation genetics and is appealing in its general lack of overt advocacy, while the final section provides meaningful

  20. Biodiversity and Conservation Research

    NSDL National Science Digital Library

    The Center for Biodiversity and Conservation (CBC) at the American Museum of Natural History aims to "integrate scientific research, education, and outreach so that people, themselves major catalysts in the rapid loss of biodiversity, will become participants in its conservation." The CBC currently conducts biodiversity conservation research in the Bahamas, Bolivia, Madagascar, Vietnam, and in metropolitan New York.

  1. Energy Conservation Renewable Energy

    E-print Network

    Delgado, Mauricio

    Energy Conservation Renewable Energy The Future at Rutgers University Facilities & Capital Planning Operations & Services Utilities Operations 6 Berrue Circle Piscataway, NJ 08854 #12;Energy Conservation Wh C ti ? R bl EWhy Conservation? Renewable Energy · Climate control reduces green house gases · Reduces

  2. Conservation in Physics.

    ERIC Educational Resources Information Center

    Finkel, Edward

    1991-01-01

    Discussed is the physical concept of conservation as it is framed within the laws of conservation of mass, of momentum, and of energy. The derivation of Ohm's Law as a generalization of the relationship between the observed measurements of voltage and current serves as the exemplar of how conservation theories are formed. (JJK)

  3. Natural Resources Conservation Service: Backyard Conservation

    NSDL National Science Digital Library

    The Natural Resources Conservation Service, a division of the U.S. Department of Agriculture, has a feature on their website on backyard conservation. Conservation practices used on agricultural land throughout the country have been adapted for the smaller scale of backyards. Not only can visitors download and print out a 28-page booklet in English or Spanish, but they can also download and print out eight tip sheets on backyard conversation. Information on how to order the free above-mentioned material, through the mail, is also provided. Using the link in the middle of the page, "See More Tips and Topics on Backyard Conservation", visitors can read over 30 archived tips and topics, including "Invite a Toad to Dinner", "Selecting the Right Tree", and "Dream Yard". For teachers, the link "Backyard Conservation Lesson Plans" in the middle of the page provides a variety of lesson plans. Some of the lessons included are "Team Flight", which is about birds; "Growing Native", which is about native plant communities; and "Backyard Conservation and Local Laws", which is about how community laws may help or hinder backyard conservation efforts. A mock city council hearing is the final activity of the lesson.

  4. The PAR Proteins: Fundamental Players in Animal Cell Polarization

    PubMed Central

    Goldstein, Bob; Macara, Ian G.

    2010-01-01

    The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning in the early embryo of C. elegans, and encode six different proteins required for asymmetric cell division by the worm zygote. Some of the PAR proteins are localized asymmetrically and form physical complexes with one another. Strikingly, the PAR proteins have been found to regulate cell polarization in many different contexts in diverse animals, suggesting they form part of an ancient and fundamental mechanism for cell polarization. Although the picture of how the PAR proteins function remains incomplete, cell biology and biochemistry are beginning to explain how PAR proteins polarize cells. PMID:17981131

  5. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2014-01-01 2014-01-01 false Conservation plans and conservation systems. 12.23 Section 12.23 Agriculture...Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Highly Erodible Land Conservation §...

  6. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2011-01-01 2011-01-01 false Conservation plans and conservation systems. 12.23 Section 12.23 Agriculture...Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Highly Erodible Land Conservation §...

  7. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2013-01-01 2013-01-01 false Conservation plans and conservation systems. 12.23 Section 12.23 Agriculture...Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Highly Erodible Land Conservation §...

  8. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2010-01-01 2010-01-01 false Conservation plans and conservation systems. 12.23 Section 12.23 Agriculture...Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Highly Erodible Land Conservation §...

  9. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2012-01-01 2012-01-01 false Conservation plans and conservation systems. 12.23 Section 12.23 Agriculture...Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION Highly Erodible Land Conservation §...

  10. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists.

    PubMed

    Compton, S J; Cairns, J A; Palmer, K J; Al-Ani, B; Hollenberg, M D; Walls, A F

    2000-12-15

    Protease-activated receptor 2 (PAR2) is a trypsin-activated member of a family of G-protein-coupled PARs. We have identified a polymorphic form of human PAR2 (PAR(2)F240S) characterized by a phenylalanine to serine mutation at residue 240 within extracellular loop 2, with allelic frequencies of 0.916 (Phe(240)) and 0.084 (Ser(240)) for the wild-type and mutant alleles, respectively. Elevations in intracellular calcium were measured in permanently transfected cell lines expressing the receptors. PAR(2)F240S displayed a significant reduction in sensitivity toward trypsin ( approximately 3.7-fold) and the PAR2-activating peptides, SLIGKV-NH(2) ( approximately 2.5-fold) and SLIGRL-NH(2) ( approximately 2.8-fold), but an increased sensitivity toward the selective PAR2 agonist, trans-cinnamoyl-LIGRLO-NH(2) ( approximately 4-fold). Increased sensitivity was also observed toward the selective PAR-1 agonist, TFLLR-NH(2) ( approximately 7-fold), but not to other PAR-1 agonists tested. Furthermore, we found that TLIGRL-NH(2) and a PAR4-derived peptide, trans-cinnamoyl-YPGKF-NH(2), were selective PAR(2)F240S agonists. By introducing the F240S mutation into rat PAR2, we observed shifts in agonist potencies that mirrored the human PAR(2)F240S, suggesting that Phe(240) is involved in determining agonist specificity of PAR2. Finally, differences in receptor signaling were paralleled in a cell growth assay. We suggest that the distinct pharmacological profile induced by this polymorphism will have important implications for the design of PAR-targeted agonists/antagonists and may contribute to, or be predictive of, an inflammatory disease. PMID:10995771

  11. Exactly conservative integrators

    SciTech Connect

    Shadwick, B.A.; Bowman, J.C.; Morrison, P.J.

    1995-07-19

    Traditional numerical discretizations of conservative systems generically yield an artificial secular drift of any nonlinear invariants. In this work we present an explicit nontraditional algorithm that exactly conserves invariants. We illustrate the general method by applying it to the Three-Wave truncation of the Euler equations, the Volterra-Lotka predator-prey model, and the Kepler problem. We discuss our method in the context of symplectic (phase space conserving) integration methods as well as nonsymplectic conservative methods. We comment on the application of our method to general conservative systems.

  12. Conservation: Toward firmer ground

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The following aspects of energy conservation were reviewed in order to place the problems in proper perspective: history and goals, conservation accounting-criteria, and a method to overcome obstacles. The effect of changing prices and available supplies of energy sources and their causes on consumption levels during the last few decades were described. Some examples of attainable conservation goals were listed and justified. A number of specific criteria applicable to conservation accounting were given. Finally, a discussion was presented to relate together the following aspects of energy conservation: widespread impact, involvement of government, industry, politics, moral and ethical aspects, urgency and time element.

  13. Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy.

    PubMed

    Burda, Joshua E; Radulovic, Maja; Yoon, Hyesook; Scarisbrick, Isobel A

    2013-09-01

    Kallikrein 6 (KLK6) is a secreted serine protease preferentially expressed by oligodendroglia in CNS white matter. Elevated levels of KLK6 occur in actively demyelinating multiple sclerosis (MS) lesions and in cases of spinal cord injury (SCI), stroke, and glioblastoma. Taken with recent evidence establishing KLK6 as a CNS-endogenous activator of protease-activated receptors (PARs), we hypothesized that KLK6 activates a subset of PARs to regulate oligodendrocyte physiology and potentially pathophysiology. Here, primary oligodendrocyte cultures derived from wild type or PAR1-deficient mice and the murine oligodendrocyte cell line, Oli-neu, were used to demonstrate that Klk6 (rodent form) mediates loss of oligodendrocyte processes and impedes morphological differentiation of oligodendrocyte progenitor cells (OPCs) in a PAR1-dependent fashion. Comparable gliopathy was also elicited by the canonical PAR1 agonist, thrombin, as well as PAR1-activating peptides (PAR1-APs). Klk6 also exacerbated ATP-mediated oligodendrogliopathy in vitro, pointing to a potential role in augmenting excitotoxicity. In addition, Klk6 suppressed the expression of proteolipid protein (PLP) RNA in cultured oligodendrocytes by a mechanism involving PAR1-mediated Erk1/2 signaling. Microinjection of PAR1 agonists, including Klk6 or PAR1-APs, into the dorsal column white matter of PAR1(+/+) but not PAR1(-/-) mice promoted vacuolating myelopathy and a loss of immunoreactivity for myelin basic protein (MBP) and CC-1(+) oligodendrocytes. These results demonstrate a functional role for Klk6-PAR1 signaling in oligodendroglial pathophysiology and suggest that antagonists of PAR1 or its protease agonists may represent new modalities to moderate demyelination and to promote myelin regeneration in cases of CNS white matter injury or disease. PMID:23832758

  14. NATURAL RESOURCES CONSERVATION Fisheries Ecology & Conservation

    E-print Network

    Schweik, Charles M.

    -ECON elective (SB) 4e NRC 390E Evolution & Conserv. 3f Physical Science elective 3g Total Credits 16 17 Junior credits to complete all university requirements and the requirements for Fish Biologists (GS-482 series

  15. American Bird Conservancy

    NSDL National Science Digital Library

    The American Bird Conservancy (ABC) is a nonprofit organization working to "conserve wild birds and their habitats throughout the Americas." The ABC website provides informative and useful features such as the Bird Conservation Directory, a searchable directory of contact information for professionals engaged in bird conservation throughout the Americas, and the downloadable Birdwatcher's Guide to Global Warming (last mentioned in the June 28, 2002 NSDL Scout Report for the Life Sciences). The site also provides information about ABC membership and a variety of conservation programs such as Partners in Flight, Cats Indoors, The North American Bird Conservation Initiative, and the Pesticides and Birds Campaign. Site visitors may also view past copies of the ABC newsletter; and sign up for free email bulletins containing conservation action alerts, information, and news.

  16. Allosteric activation of the Par-6 PDZ via a partial unfolding transition

    PubMed Central

    Whitney, Dustin S.; Peterson, Francis C.; Kovrigin, Evgenii L.; Volkman, Brian F.

    2013-01-01

    Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding or allosteric control. Par-6 regulates the Par polarity complex by transmitting a GTPase signal through the CRIB-PDZ module that alters PDZ lig-and binding. Allosteric activation of the PDZ is achieved by local rearrangement of the L164 and K165 side chains to stabilize the interdomain CRIB-PDZ interface and reposition a conserved element of the ligand binding pocket. However, microsecond to millisecond dynamics measurements revealed that L164/K165 exchange requires a larger rearrangement than expected. The margin of thermodynamic stability for the PDZ domain is modest (~3 kcal/mol) and further reduced by transient interactions with the disordered CRIB domain. Measurements of local structural stability revealed that tertiary contacts within the PDZ are disrupted by a partial unfolding transition that enables interconversion of the L/K switch. The unexpected participation of partial PDZ unfolding in the allosteric mechanism of Par-6 suggests that native-state unfolding may be essential for the function of other marginally stable proteins. PMID:23705660

  17. Les fréquences décrites par Paul Nogier

    Microsoft Academic Search

    Y. Rouxeville

    \\u000a Au début des années soixante-dix, nous utilisions l’EMS® avec la gamme des fréquences initiales décrites par Paul Nogier.\\u000a Ce sont des harmoniques : 2,5 Hz (A), 5 Hz (B), 10 Hz (C), 20 Hz (D), 40 Hz (E), 80 Hz (F), et 160 Hz (G). Tous les utilisateurs\\u000a en étaient fort satisfaits.

  18. Series chronologiques Prevision par lissage exponentiel

    E-print Network

    Lagnoux Renaudie, Agnès

    S´eries chronologiques - Pr´evision par lissage exponentiel Agn`es LAGNOUX lagnoux@univ-tlse2.fr pr´evision qui accordent plus ou moins d'importance aux valeurs du pass´e d'une s´erie temporelle + St + t. t Z, Xt = ZtSt + t. avec Zt une s´erie constante ou lin´eaire. #12;Le lissage exponentiel

  19. Microscopie en champ proche par réflexion

    NASA Astrophysics Data System (ADS)

    Spajer, M.; Courjon, D.; Sarayeddine, K.; Jalocha, A.; Vigoureux, J.-M.

    1991-01-01

    This communication presents two techniques for high resolution surface analysis. In the first one, the illumination beam is totally reflected under the object surface, which must be transparent. The evanescent wave confined on the surface is frustrated locally by a dielectric probe of nanometric dimension which scans the objetc. A horizontal resolution of 10 nm and a vertical one of 1 nm have been obtained. In the second one, more adapted to metallic objects, the surface is illuminated by the near-field of the stylus, in which the reflected beam is Partially launched. First results dealing with the characterization of the dielectric stylus are presented. Cette communication présente deux techniques permettant l'analyse de surface haute résolution. Dans la première, le faisceau d'éclairage est réfléchi totalement sous la surface de l'objet, nécessairement transparent. L'onde évanescente qui l'accompagne est frustrée localement par une pointe diélectrique de dimension nanométrique balayant la surface. Une résolution de 10 nm horizontalement et de 1nm verticalement a été obtenue. Dans la seconde, qui permet d'étudier un objet opaque, celui-ci est éclairé par le champ proche émis par la pointe, dans laquelle le faisceau réfléchi est partiellement réinjecté. Les premiers résultats concernant la caractérisation de la pointe sont présentés.

  20. Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32.

    PubMed

    Boeckstaens, Mélanie; Merhi, Ahmad; Llinares, Elisa; Van Vooren, Pascale; Springael, Jean-Yves; Wintjens, René; Marini, Anna Maria

    2015-07-01

    Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocytosis of amino-acid transporters. Ammonium is a ubiquitous compound playing key physiological roles in many, if not all, organisms. In yeast, it is a preferred nitrogen source transported by three Mep proteins which are orthologues of the mammalian Rhesus factors. By combining genetic, kinetic, biochemical and cell microscopy analyses, the current study reveals a novel mechanism enabling TORC1 to regulate the inherent activity of ammonium transport proteins, independently of arrestin-mediated endocytosis, identifying the still functional orphan Amu1/Par32 as a selective regulator intermediate. We show that, under poor nitrogen supply, the TORC1 effector kinase' Npr1' promotes phosphorylation of Amu1/Par32 which appears mainly cytosolic while ammonium transport proteins are active. Upon preferred nitrogen supplementation, like glutamine or ammonium addition, TORC1 upregulation enables Npr1 inhibition and Amu1/Par32 dephosphorylation. In these conditions, as in Npr1-lacking cells, hypophosphorylated Amu1/Par32 accumulates at the cell surface and mediates the inhibition of specific ammonium transport proteins. We show that the integrity of a conserved repeated motif of Amu1/Par32 is required for the interaction with these transport proteins. This study underscores the diversity of strategies enabling TORC1-Npr1 to selectively monitor cell permeability to nutrients by discriminating between transporters to be degraded or transiently inactivated and kept stable at the plasma membrane. This study further identifies the function of Amu1/Par32 in acute control of ammonium transport in response to variations in nitrogen availability. PMID:26172854

  1. Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32

    PubMed Central

    Boeckstaens, Mélanie; Merhi, Ahmad; Llinares, Elisa; Van Vooren, Pascale; Springael, Jean-Yves; Wintjens, René; Marini, Anna Maria

    2015-01-01

    Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocytosis of amino-acid transporters. Ammonium is a ubiquitous compound playing key physiological roles in many, if not all, organisms. In yeast, it is a preferred nitrogen source transported by three Mep proteins which are orthologues of the mammalian Rhesus factors. By combining genetic, kinetic, biochemical and cell microscopy analyses, the current study reveals a novel mechanism enabling TORC1 to regulate the inherent activity of ammonium transport proteins, independently of arrestin-mediated endocytosis, identifying the still functional orphan Amu1/Par32 as a selective regulator intermediate. We show that, under poor nitrogen supply, the TORC1 effector kinase' Npr1' promotes phosphorylation of Amu1/Par32 which appears mainly cytosolic while ammonium transport proteins are active. Upon preferred nitrogen supplementation, like glutamine or ammonium addition, TORC1 upregulation enables Npr1 inhibition and Amu1/Par32 dephosphorylation. In these conditions, as in Npr1-lacking cells, hypophosphorylated Amu1/Par32 accumulates at the cell surface and mediates the inhibition of specific ammonium transport proteins. We show that the integrity of a conserved repeated motif of Amu1/Par32 is required for the interaction with these transport proteins. This study underscores the diversity of strategies enabling TORC1-Npr1 to selectively monitor cell permeability to nutrients by discriminating between transporters to be degraded or transiently inactivated and kept stable at the plasma membrane. This study further identifies the function of Amu1/Par32 in acute control of ammonium transport in response to variations in nitrogen availability. PMID:26172854

  2. Peptide Binding Properties of the Three PDZ Domains of Bazooka (Drosophila Par-3)

    PubMed Central

    Yu, Cao Guo; Tonikian, Raffi; Felsensteiner, Corinna; Jhingree, Jacquelyn R.; Desveaux, Darrell; Sidhu, Sachdev S.; Harris, Tony J. C.

    2014-01-01

    The Par complex is a conserved cell polarity regulator. Bazooka/Par-3 is scaffold for the complex and contains three PDZ domains in tandem. PDZ domains can act singly or synergistically to bind the C-termini of interacting proteins. Sequence comparisons among Drosophila Baz and its human and C. elegans Par-3 counterparts indicate a divergence of the peptide binding pocket of PDZ1 and greater conservation for the pockets of PDZ2 and PDZ3. However, it is unclear whether the domains from different species share peptide binding preferences, or if their tandem organization affects their peptide binding properties. To investigate these questions, we first used phage display screens to identify unique peptide binding profiles for each single PDZ domain of Baz. Comparisons with published phage display screens indicate that Baz and C. elegans PDZ2 bind to similar peptides, and that the peptide binding preferences of Baz PDZ3 are more similar to C. elegans versus human PDZ3. Next we quantified the peptide binding preferences of each Baz PDZ domain using single identified peptides in surface plasmon resonance assays. In these direct binding studies, each peptide had a binding preference for a single PDZ domain (although the peptide binding of PDZ2 was weakest and the least specific). PDZ1 and PDZ3 bound their peptides with dissociation constants in the nM range, whereas PDZ2-peptide binding was in the µM range. To test whether tandem PDZ domain organization affects peptide binding, we examined a fusion protein containing all three PDZ domains and their normal linker regions. The binding strengths of the PDZ-specific peptides to single PDZ domains and to the PDZ domain tandem were indistinguishable. Thus, the peptide binding pockets of each PDZ domain in Baz are not obviously affected by the presence of neighbouring PDZ domains, but act as isolated modules with specific in vitro peptide binding preferences. PMID:24466078

  3. Conservation: Toward firmer ground

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The following aspects of energy conservation were discussed: conservation history and goals, conservation modes, conservation accounting-criteria, and a method to overcome obstacles. The conservation modes tested fall into one of the following categories: reduced energy consumption, increased efficiency of energy utilization, or substitution of one or more forms of energy for another which is in shorter supply or in some sense thought to be of more value. The conservation accounting criteria include net energy reduction, economic, and technical criteria. A method to overcome obstacles includes (approaches such as: direct personal impact (life style, income, security, aspiration), an element of crisis, large scale involvement of environmental, safety, and health issues, connections to big government, big business, big politics, involvement of known and speculative science and technology, appeal to moral and ethical standards, the transient nature of opportunities to correct the system.

  4. Society for Conservation Biology

    NSDL National Science Digital Library

    Founded in 1985, the "Society for Conservation Biology (SCB) is an international professional organization dedicated to promoting the scientific study of phenomena that affect the maintenance, loss, and restoration of biological diversity." Online services provided by SCB include a great conservation jobs database; a bulletin board for conservation-related postings; listings for educational resources, and academic programs in the field of Conservation Biology. Site visitors can also peruse SCB annual reports, archived online newsletters, and information about local chapters, committees, membership, and meetings.

  5. Solar ultraviolet-B and photosynthetically active irradiance in the urban sub-canopy: A survey of influences

    Microsoft Academic Search

    Richard H. Grant; Gordon M. Heisler

    1996-01-01

    Stratospheric ozone loss in mid-latitudes is expected to increase the ultraviolet-B (UVB) radiation at the earth's surface. Impacts of this expected increase will depend on many factors, including the distribution of light in other wavelengths. Measurements of the photosynthetically active radiation (PAR) and UVB irradiance were made under clear skies at an open field and under the canopy of scattered

  6. A new method for PAR reduction in baseband DMT systems

    Microsoft Academic Search

    Brian S. Krongold; Douglas L. Jones

    2001-01-01

    The high peak-to-average power ratio (PAR) in real-baseband discrete multitone modulation (DMT) systems can significantly limit performance. Tone reservation techniques use unavailable or reserved tones to design a peak-cancelling signal that lowers the PAR of a transmit data block. Previous methods converge very slowly to a good solution. Our new active-set method converges much faster toward a minimum-PAR solution at

  7. PRODUCTION DES GRANDES VITESSES ANGULAIRES (1); Par M. MAURICE LEBLANC.

    E-print Network

    Paris-Sud XI, Université de

    redresser l'arbre flexible et à ramener son axe neutre en coïncidence avec l'axe 00'. Supposons d'abord le rotor parfaitement équilibré, par rapport à son axe de figure uv, qui sera alors son axe naturel de rotation et se confondra avec l'axe x~ de la figure 7. Désignons par 1 le moment d'inertie du rotor, par

  8. Soft tissue sarcoma. Integration of brachytherapy, resection, and external irradiation

    SciTech Connect

    Schray, M.F.; Gunderson, L.L.; Sim, F.H.; Pritchard, D.J.; Shives, T.C.; Yeakel, P.D. (Mayo Clinic, Rochester, MN (USA))

    1990-08-01

    Between December 1981 and August 1988, 63 patients with clinically localized nonretroperitoneal soft tissue sarcomas underwent 65 brachytherapy procedures in conjunction with conservative resection with (61 tumors) or without (four tumors) external beam irradiation. Implant doses of 1500 to 2000 cGy were combined with 4500 to 5000 cGy of external irradiation. External irradiation was given preoperatively for larger lesions near bone or neurovascular structures, whereas it was used postoperatively for smaller, more resectable lesions or those that had previously been inadequately excised. There were 47 high-grade tumors, 34 tumors greater than 5 cm, and nine patients with recurrent lesions (five with previous irradiation). With mean follow-up of 20 months, conclusions on local control are tentative, but only two of 56 tumors (4%) with brachytherapy as part of initial management had recurred locally and three of nine recurrent tumors had re-recurred locally. Only one of five local recurrences was within the implanted volume. Only two of 40 implantations (5%) performed at initial resection followed by postoperative external irradiation led to wound complications, whereas four of 16 implantations (25%) performed at resection after preoperative external irradiation were associated with wound problems. This technique does not increase local morbidity and may enhance local tumor control in comparison with either external radiation or brachytherapy alone as an adjuvant to conservative resection. 15 references.

  9. Mechanism of DNA segregation in prokaryotes: Replicon pairing by parC of plasmid R1

    PubMed Central

    Jensen, Rasmus Bugge; Lurz, Rudi; Gerdes, Kenn

    1998-01-01

    Prokaryotic chromosomes and plasmids encode partitioning systems that are required for DNA segregation at cell division. The systems are thought to be functionally analogous to eukaryotic centromeres and to play a general role in DNA segregation. The parA system of plasmid R1 encodes two proteins ParM and ParR, and a cis-acting centromere-like site denoted parC. The ParR protein binds to parC in vivo and in vitro. The ParM protein is an ATPase that interacts with ParR specifically bound to parC. Using electron microscopy, we show here that parC mediates efficient pairing of plasmid molecules. The pairing requires binding of ParR to parC and is stimulated by the ParM ATPase. The ParM mediated stimulation of plasmid pairing is dependent on ATP hydrolysis by ParM. Using a ligation kinetics assay, we find that ParR stimulates ligation of parC-containing DNA fragments. The rate-of-ligation was increased by wild type ParM protein but not by mutant ParM protein deficient in the ATPase activity. Thus, two independent assays show that parC mediates pairing of plasmid molecules in vitro. These results are consistent with the proposal that replicon pairing is part of the mechanism of DNA segregation in prokaryotes. PMID:9671715

  10. Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa

    PubMed Central

    2013-01-01

    Background The ParS/ParR two component regulatory system plays critical roles for multidrug resistance in Pseudomonas aeruginosa. It was demonstrated that in the presence of antimicrobials, ParR enhances bacterial survival by distinct mechanisms including activation of the mexXY efflux genes, enhancement of lipopolysaccharide modification through the arn operon, and reduction of the expression of oprD porin. Results In this study, we report on transcriptomic analyses of P. aeruginosa PAO1 wild type and parS and parR mutants growing in a defined minimal medium. Our transcriptomic analysis provides the first estimates of transcript abundance for the 5570 coding genes in P. aeruginosa PAO1. Comparative transcriptomics of P. aeruginosa PAO1 and par mutants identified a total of 464 genes regulated by ParS and ParR. Results also showed that mutations in the parS/parR system abolished expression of the mexEF-oprN operon by down-regulating the regulatory gene mexS. In addition to the known effects on drug resistance genes, transcript abundances of the quorum sensing genes (rhlIR and pqsABCDE-phnAB) were higher in both parS and parR mutants. In accordance with these results, a significant portion of the ParS/ParR regulated genes belonged to the MexEF-OprN and quorum sensing regulons. Deletion of the par genes also led to increased phenazine production and swarming motility, consistent with the up-regulation of the phenazine and rhamnolipid biosynthetic genes, respectively. Conclusion Our results link the ParS/ParR two component signal transduction system to MexEF-OprN and quorum sensing systems in P. aeruginosa. These results expand our understanding of the roles of the ParS/ParR system in the regulation of gene expression in P. aeruginosa, especially in the absence of antimicrobials. PMID:24034668

  11. ParABS System in Chromosome Partitioning in the Bacterium Myxococcus xanthus

    PubMed Central

    Iniesta, Antonio A.

    2014-01-01

    Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster. PMID:24466283

  12. THROMBIN REGULATES METASTATIC POTENTIAL OF HUMAN RHABDOMYOSARCOMA CELLS – DISTINCT ROLE OF PAR1 AND PAR3 SIGNALING

    PubMed Central

    Wysoczynski, Marcin; Rui, Liu; Kucia, Magda; Drukala, Justyna; Ratajczak, Mariusz Z.

    2010-01-01

    We observed that human rhabdomyosarcoma (RMS) cells highly express a tissue factor (TF) that promotes thrombin formation, which indirectly and directly affects RMS progression. First, we found that thrombin activates platelets to generate microvesicles (PMVs), which transfer to RMS cells’ ?2?3 integrin and increase their adhesiveness to endothelial cells. Accordingly, RMS cells covered with PMVs showed higher metastatic potential after intravenous injection into immunodeficient mice. Furthermore, PMVs activate mitogen-activated protein kinase (MAPK)p42/44 and AKT to chemoattract RMS cells. We also found that RMS cells express functional protease-activated receptor-1 (PAR1) and PAR3 and respond to thrombin stimulation by MAPKp42/44 and MAPKp38 phosphorylation. To our surprise, thrombin did not affect RMS proliferation or survival; it inhibited RMS cells’ chemotactic and adhesive properties. However, when PAR1-specific agonist thrombin receptor-activating peptide (TRAP)6 was employed, which does not activate PAR3, selective PAR1 stimulation enhanced RMS proliferation. To learn more on the role of PAR1 and PAR3 antagonism in RMS proliferation and metastasis, we knocked down both receptors by employing a short hairpin (sh)RNA strategy. We found that while thrombin does not affect growth of PAR1?/? cells, it stimulated proliferation of PAR3?/? cells. More importantly, PAR3?/? cells, in contrast to PAR1?/? ones, formed larger tumors in immunodeficient mice. We conclude that thrombin is a novel; underappreciated modulator of RMS metastasis and that we have identified a novel role for PAR3 in thrombin signaling. PMID:20442298

  13. Conservation--Selected Bibliography.

    ERIC Educational Resources Information Center

    Australian Conservation Foundation, Parkville, Victoria.

    Developed by the Australian Conservation Foundation to meet the need for a general conservation bibliography, this booklet offers resources for a wide spectrum of possible users. Material selected is that which is relevant and helpful for conservationists in their various fields of activity and what is likely to be in print and obtainable without…

  14. Marine Conservation Resource overexploitation

    E-print Network

    'target species impact Non'target species: Bycatch · Gill net# pelagic: % N Pacific squid# tuna: ·!&! million % Bluefin tunas# Southern Ocean · )!& million hooks in peak year )1*& · Wandering albatrosses declined for the Conservation of Atlantic Tuna -ICCAT. % But Bluefin tuna down 1$+ since )10$ Marine conservation laws

  15. Conservation and Development.

    ERIC Educational Resources Information Center

    Salim, Emil

    1982-01-01

    Discusses conservation and development from Indonesian viewpoint, focusing on problems encountered in the process of development and reconciling development with conservation. Topics addressed include pressures of population growth, concern for man and eco-development, global considerations, trends after Stockholm conference (common responsibility…

  16. Fresh Water Conservation 

    E-print Network

    Huffman, L.

    2011-01-01

    , Texas, Nov. 7 ? 9, 2011 Central Texas is a model of conservation. ESL-KT-11-11-06 CATEE 2011, Dallas, Texas, Nov. 7 ? 9, 2011 Water conservation can be incentivized. ESL-KT-11-11-06 CATEE 2011, Dallas, Texas, Nov. 7 ? 9, 2011 Take care...

  17. Systematic conservation planning

    Microsoft Academic Search

    C. R. Margules; R. L. Pressey

    2000-01-01

    The realization of conservation goals requires strategies for managing whole landscapes including areas allocated to both production and protection. Reserves alone are not adequate for nature conservation but they are the cornerstone on which regional strategies are built. Reserves have two main roles. They should sample or represent the biodiversity of each region and they should separate this biodiversity from

  18. AVIAN ECOLOGY AND CONSERVATION

    E-print Network

    Fernández-Juricic, Esteban

    AVIAN ECOLOGY AND CONSERVATION IN AN URBANIZING WORLD edited by John M. Marzluff College of Forest...............................................................................49 4. Human perception and appreciation of birds: A motivation for wildlife conservation in urban and wildland Florida Scrub-Jays: Do physiologic measures reflect different environments? Stephan J. Schoech

  19. Global conservation strategy

    Microsoft Academic Search

    Talbot

    1981-01-01

    The World Conservation Strategy, prepared by the United Nations and other international groups, recognizes that conservation and development are related. This relationship was incorporated into the goals, priorities, and the framework for action set out in the strategy to optimize the management and use of world resources. A review of the results since the strategy was launched in world capitals

  20. On exactly conservative integrators

    SciTech Connect

    Bowman, J.C. [Max-Planck-Inst. fuer Plasmaphysik, Garching (Germany); Shadwick, B.A. [Univ. of California, Berkeley, CA (United States). Dept. of Physics; Morrison, P.J. [Texas Univ., Austin, TX (United States). Inst. for Fusion Studies

    1997-06-01

    Traditional explicit numerical discretizations of conservative systems generically predict artificial secular drifts of nonlinear invariants. These algorithms are based on polynomial functions of the time step. The authors discuss a general approach for developing explicit algorithms that conserve such invariants exactly. They illustrate the method by applying it to the truncated two-dimensional Euler equations.

  1. Outdoor Water Conservation

    E-print Network

    Balasundaram, Balabhaskar "Baski"

    L-438 Outdoor Water Conservation The City of OKLAHOMA CITY UTILITIES DEPARTMENT Oklahoma.JustinQ.Moss 1 #12;2 SEVEN PRINCIPLES FOR CREATING A WATER CONSERVING LANDSCAPE 1. GOOD LANDSCAPE PLANNING Cooperative Extension Service Division of Agricultural Sciences and Natural Resources Oklahoma State

  2. Take Action: Water Conservation

    NSDL National Science Digital Library

    Jessica Fries-Gaither

    In this regular column of the free, online magazine Beyond Weather and the Water Cycle, the author looks at the importance of conserving water and practicing good conservation habits daily. The column is designed for teachers in K-Grade 5 classrooms and presents concepts of climate literacy that are appropriate for young children. Identified online resources provide data collection activities, lessons, and games.

  3. Water Conservation Resource List.

    ERIC Educational Resources Information Center

    NJEA Review, 1981

    1981-01-01

    Alarmed by the growing water shortage, the New Jersey State Office of Dissemination has prepared this annotated list of free or inexpensive instructional materials for teaching about water conservation, K-l2. A tipsheet for home water conservation is appended. (Editor/SJL)

  4. Teaching Teachers Conservation.

    ERIC Educational Resources Information Center

    Meyers, N. L.; And Others

    1987-01-01

    Describes a two-week summer course for elementary and secondary teachers on soil and water conservation taught in Wisconsin. Discusses the efforts to recruit teachers for the course, the course content, the field trips, and the evaluation procedures. Stresses the cooperation between educators and conservation agencies in developing the course. (TW)

  5. Fresh Water Conservation

    E-print Network

    Huffman, L.

    2011-01-01

    , Texas, Nov. 7 ? 9, 2011 Central Texas is a model of conservation. ESL-KT-11-11-06 CATEE 2011, Dallas, Texas, Nov. 7 ? 9, 2011 Water conservation can be incentivized. ESL-KT-11-11-06 CATEE 2011, Dallas, Texas, Nov. 7 ? 9, 2011 Take care...

  6. Scanning the Conservation Horizon

    E-print Network

    Scanning the Conservation Horizon A Guide to Climate Change Vulnerability Assessment #12;Scanning Vulnerability Assessment. National Wildlife Federation, Washington, D.C. ISBN 978-0-615-40233-8 Financial.nwf.org #12;A Guide to Climate Change Vulnerability Assessment ii Scanning the Conservation Horizon A Guide

  7. Ecosystems emerging: 1. conservation

    Microsoft Academic Search

    Bernard C. Patten; Milan Straškraba; Sven E. Jørgensen

    1997-01-01

    This second paper in the series on Ecosystems Emerging treats some properties of ecosystems derivable from the single elementary principle of conservation. These go beyond the mere balancing out of the matter and forces of nature.A brief sketch of a conservationless world is given, followed by an elementary background review of energy, matter and information. The main conservative quantities are

  8. Global Biodiversity Conservation Priorities

    E-print Network

    Wilmers, Chris

    Global Biodiversity Conservation Priorities T. M. Brooks,1,2,3 * R. A. Mittermeier,1 G. A. B. da. Rodrigues5 The location of and threats to biodiversity are distributed unevenly, so prioritization is essential to minimize biodiversity loss. To address this need, biodiversity conservation organizations have

  9. Resource Conservation Glossary.

    ERIC Educational Resources Information Center

    Soil Conservation Society of America, Ankeny, IA.

    This glossary is a composite of terms selected from 13 technologies, and is the expanded revision of the original 1952 edition of "The Soil and Water Conservation Glossary." The terms were selected from these areas: agronomy, biology, conservation, ecology, economics, engineering, forestry, geology, hydrology, range, recreation, soils, and…

  10. The Candidates and Conservation

    ERIC Educational Resources Information Center

    Sierra Club Bulletin, 1976

    1976-01-01

    Information is provided on the 1976 Democratic and Republican presidential candidates' positions on issues related to conservation and the environment. This information was drawn from public statements, official administration positions (state and federal) and candidate questionnaires prepared by the National League of Conservation Voters. (BT)

  11. Fractional conservation of mass

    Microsoft Academic Search

    Stephen W. Wheatcraft; Mark M. Meerschaert

    2008-01-01

    The traditional conservation of mass equation is derived using a first-order Taylor series to represent flux change in a control volume, which is valid strictly for cases of linear changes in flux through the control volume. We show that using higher-order Taylor series approximations for the mass flux results in mass conservation equations that are intractable. We then show that

  12. Conservation of Momentum 1

    NSDL National Science Digital Library

    Michael Horton

    2009-05-30

    This lab introduces students to the idea of recoil and how conservation of momentum can be used to explain it. Many people use action/reaction to explain recoil, but conservation of momentum can be used equally well. Before shooting a gun, there is zero m

  13. NATURAL RESOURCES CONSERVATION Fisheries Ecology & Conservation

    E-print Network

    Schweik, Charles M.

    -ECON elective (SB) 4e NRC 390E Evolution & Conserv. 3f Physical Science elective 3g Total Credits 16 17 Junior and the requirements for Fish Biologists (GS-482 series) with the US Department of Interior. To qualify as an Associate

  14. Biodiversity Conservation and Conservation Biotechnology Tools

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This special issue is dedicated to the in vitro tools and methods used to conserve the genetic diversity of rare and threatened species from around the world. Species that are on the brink of extinction, due to the rapid loss of genetic diversity and habitat, come mainly from resource poor areas the...

  15. Springtime size-fractionated primary production across hydrographic and PAR-light gradients in Chilean Patagonia (41-50°S)

    NASA Astrophysics Data System (ADS)

    Jacob, Bárbara G.; Tapia, Fabián J.; Daneri, Giovanni; Iriarte, Jose L.; Montero, Paulina; Sobarzo, Marcus; Quiñones, Renato A.

    2014-12-01

    We combined on-deck and in situ measurements and satellite-derived data to study the spatial variability of springtime size-fractionated primary production and chlorophyll-a biomass along gradients of hydrographic conditions and surface PAR in central and northern Chilean Patagonia (41-50°S). This extensive and fragmented region encompasses numerous fjords and channels, as well as the northern and southern icefields (46-47°S, 48-52°S). Primary production displayed a latitudinal pattern decreasing southwards (6-fold lower), particularly toward areas influenced by rivers with a nival regime. Micro-phytoplankton (>20 ?m) dominated the primary production (57-93%) and chlorophyll-a (43-91%) of northern sites, where warmer and more saline surface waters exhibit greater PAR irradiance. Small phytoplankton cells (<2 ?m; 2-20 ?m) contributed > 50% of carbon fixation and chlorophyll-a in the southernmost sites, especially those located near glaciers and major rivers, where surface temperature, salinity, and PAR irradiance were lowest. The long-term (2002-2012) average field of springtime PAR derived from satellite imagery showed a southward increase in longitudinal gradients, which indicates that spatial changes in surface light attenuation along this region are largely driven by glacier-derived freshwater inputs. A principal component analysis of surface temperature, salinity, and PAR produced an ordination of sites that was consistent with spatial changes in the balance of oceanic versus riverine influence on surface conditions along this region. Total primary production was significantly correlated (r = 0.61, p = 0.007) with the first principal component, which explained 65% of joint variability in hydrographic conditions and PAR. The same principal component clearly separated sites in northern Patagonia where micro-phytoplankton dominated total primary production - along the Reloncavi fjord and Inner Sea of Chiloe - from those located further south where other size fractions were equally or more important. We stress the need to include spatial variability in nutrient concentrations, which together with the strong light attenuation induced by glacier-derived freshwater may further explain the spatial patterns in primary productivity, phytoplankton biomass, and carbon fluxes along Chilean Patagonia.

  16. Wilderness and biodiversity conservation

    NASA Astrophysics Data System (ADS)

    Mittermeier, R. A.; Mittermeier, C. G.; Brooks, T. M.; Pilgrim, J. D.; Konstant, W. R.; da Fonseca, G. A. B.; Kormos, C.

    2003-09-01

    Human pressure threatens many species and ecosystems, so conservation efforts necessarily prioritize saving them. However, conservation should clearly be proactive wherever possible. In this article, we assess the biodiversity conservation value, and specifically the irreplaceability in terms of species endemism, of those of the planet's ecosystems that remain intact. We find that 24 wilderness areas, all > 1 million hectares, are > 70% intact and have human densities of less than or equal to five people per km2. This wilderness covers 44% of all land but is inhabited by only 3% of people. Given this sparse population, wilderness conservation is cost-effective, especially if ecosystem service value is incorporated. Soberingly, however, most wilderness is not speciose: only 18% of plants and 10% of terrestrial vertebrates are endemic to individual wildernesses, the majority restricted to Amazonia, Congo, New Guinea, the Miombo-Mopane woodlands, and the North American deserts. Global conservation strategy must target these five wildernesses while continuing to prioritize threatened biodiversity hotspots.

  17. Wildlife Conservation Society

    NSDL National Science Digital Library

    Founded in 1895 as the New York Zoological Society, the re-named Wildlife Conservation Society (WCS) works "to save wildlife and wild lands throughout the world." WCS has five public facilities in New York City, where zoologists, veterinarians, zookeepers, teachers, health technicians, trainers, and others care for over 1,000 species of animals. These facilities promote "conservation education, breeding of endangered species, and understanding wildlife health and science." WCS also maintains an International Conservation program, overseeing (and funding) field conservation projects in 52 countries. Although the site targets the general public, several projects of interest to researchers are listed in the Science section, and conservation programs are outlined in In The Wild.

  18. Ecologically relevant UV-B dose combined with high PAR intensity distinctly affect plant growth and accumulation of secondary metabolites in leaves of Centella asiatica L. Urban.

    PubMed

    Müller, Viola; Albert, Andreas; Barbro Winkler, J; Lankes, Christa; Noga, Georg; Hunsche, Mauricio

    2013-10-01

    We investigated the effects of environmentally relevant dose of ultraviolet (UV)-B and photosynthetic active radiation (PAR) on saponin accumulation in leaves on the example of Centella asiatica L. Urban. For this purpose, plants were exposed to one of four light regimes i.e., two PAR intensities with or without UV-B radiation. The experiment was conducted in technically complex sun simulators under almost natural irradiance and climatic conditions. As observed, UV-B radiation increased herb and leaf production as well as the content of epidermal flavonols, which was monitored by non-destructive fluorescence measurements. Specific fluorescence indices also indicate an increase in the content of anthocyanins under high PAR; this increase was likewise observed for the saponin concentrations. In contrast, UV-B radiation had no distinct effects on saponin and sapogenin concentrations. Our findings suggest that besides flavonoids, also saponins were accumulated under high PAR protecting the plant from oxidative damage. Furthermore, glycosylation of sapogenins seems to be important either for the protective function and/or for compartmentalization of the compounds. Moreover, our study revealed that younger leaves contain higher amounts of saponins, while in older leaves the sapogenins were the most abundant constituents. Concluding, our results proof that ambient dose of UV-B and high PAR intensity distinctly affect the accumulation of flavonoids and saponins, enabling the plant tissue to adapt to the light conditions. PMID:24044900

  19. Safer Food with Irradiation (Spanish) 

    E-print Network

    Thompson, Britta; Vestal, Andy; Van Laanen, Peggy

    2003-01-21

    This publication answers questions about food irradiation and how it helps prevent foodborne illnesses. Included are explanations of how irradiation works and its benefits. Irradiation is a safe method of preserving food quality and ensuring its...

  20. Historic macrophyte development in Par Pond

    SciTech Connect

    Grace, J.B.

    1985-08-01

    Aerial photographs from 1975, 1980, and 1983 were examined to evaluate the changes that have occurred in the wetland vegetation of Par Pond, a reactor-cooling reservoir. Evaluation of the aerial photographs was based on comparisons with ground-level vegetation maps made during July 1984. Comparisons of photographs from August and December of 1983 revealed the main seasonal change in the aerial coverage of wetland vegetation to be the wintertime loss of non-persistent emergent species such as Nelumbo lutea and Nymphaea odorata. Comparisons between September 1980 and August 1983 revealed that the lakeward extent of non-persistent macrophytes has increased by an average of 8.2 m, though not all sites have changed equally. For persistent macrophytes (principally Typha), the average increase in lakeward extent between December 1975 and August 1983 was 3.48 m. The extensive development of wetland vegetation in Par Pond as well as the substantial spread of vegetation over only a few years time indicates the high suitability of this habitat for the growth of wetland plants.

  1. Entérite lupique récidivante améliorée par Azathioprine

    PubMed Central

    Marzouk, Sameh; Garbaa, Saida; Cherif, Yosra; Jallouli, Moez; Bahri, Fathi; Bahloul, Zouhir

    2015-01-01

    Les manifestations gastro-intestinales observées au cours du lupus érythémateux systémique sont fréquentes et peuvent intéresser n'importe quel segment du tractus digestif. L'entérite lupique constitue l'une des manifestations responsable de douleurs abdominales. Son traitement est basé essentiellement sur les corticoïdes. Le recours aux immunosuppresseurs est réservé aux formes récidivantes ou en cas d’échec des corticoïdes. Nous rapportons une nouvelle observation d'entérite lupique récidivante améliorée par azathioprine. Il s'agissait d'une femme âgée de 30 ans chez laquelle le diagnostic du lupus a été retenu en 2004. Un an après, elle a présenté des douleurs abdominales, des vomissements et des diarrhées. Les explorations ont conclu à une entérite lupique après élimination de toute autre cause notamment infectieuse. Elle a été traitée par des corticoïdes à forte dose. Cependant à chaque tentative de dégression, elle présentait la même symptomatologie. En 2010 l'azathioprine a été associé permettant de juguler la maladie et de diminuer la corticothérapie. PMID:26113946

  2. Review of Breast Conservation Therapy: Then and Now

    PubMed Central

    Hoover, Susan; Bloom, Elizabeth; Patel, Sunil

    2011-01-01

    Breast conservation therapy (BCT), which is the marriage of breast conserving surgery and radiation therapy to the breast, has revolutionized the treatment of breast cancer over the last few decades. Surgical direction had seen a heightened interest in the performance of cosmetically superior partial and segmental resections in breast conservation as well as increased demand by patients for breast preservation. The broadening of approaches to delivery of breast irradiation from whole breast to accelerated partial breast has allowed more patients to opt for breast conservation and allowed for what appears to be comparable measurable outcomes in emerging data. As well, the addition of state-of-the-art chemotherapeutic and hormonal therapies has allowed improved outcomes of patients from both local regional recurrence and overall survival standpoints. This paper will provide an overview of BCT and review some of the newest developments in optimizing this therapy for patients with breast cancer from a surgical-, medical-, and radiation-oncology standpoint. PMID:22229101

  3. Presentee par Marcin Z DROZDOWA BYSZEWSKI

    E-print Network

    Paris-Sud XI, Université de

    part describes the recently discovered intriguing properties of the 2DEG under microwave irradiation only specific fractional filling factors were observed. The present work reports on opti- cal detection interactions and the 2DEG ­ valence band hole interactions. The observed changes of the emission energy

  4. Condensation and localization of the partitioning protein ParB on the bacterial chromosome

    PubMed Central

    Broedersz, Chase P.; Wang, Xindan; Meir, Yigal; Loparo, Joseph J.; Rudner, David Z.; Wingreen, Ned S.

    2014-01-01

    The ParABS system mediates chromosome segregation and plasmid partitioning in many bacteria. As part of the partitioning mechanism, ParB proteins form a nucleoprotein complex at parS sites. The biophysical basis underlying ParB–DNA complex formation and localization remains elusive. Specifically, it is unclear whether ParB spreads in 1D along DNA or assembles into a 3D protein–DNA complex. We show that a combination of 1D spreading bonds and a single 3D bridging bond between ParB proteins constitutes a minimal model for a condensed ParB–DNA complex. This model implies a scaling behavior for ParB-mediated silencing of parS-flanking genes, which we confirm to be satisfied by experimental data from P1 plasmids. Furthermore, this model is consistent with experiments on the effects of DNA roadblocks on ParB localization. Finally, we show experimentally that a single parS site is necessary and sufficient for ParB–DNA complex formation in vivo. Together with our model, this suggests that ParB binding to parS triggers a conformational switch in ParB that overcomes a nucleation barrier. Conceptually, the combination of spreading and bridging bonds in our model provides a surface tension ensuring the condensation of the ParB–DNA complex, with analogies to liquid-like compartments such as nucleoli in eukaryotes. PMID:24927534

  5. Irradiation Creep in Graphite

    SciTech Connect

    Ubic, Rick; Butt, Darryl; Windes, William

    2014-03-13

    An understanding of the underlying mechanisms of irradiation creep in graphite material is required to correctly interpret experimental data, explain micromechanical modeling results, and predict whole-core behavior. This project will focus on experimental microscopic data to demonstrate the mechanism of irradiation creep. High-resolution transmission electron microscopy should be able to image both the dislocations in graphite and the irradiation-induced interstitial clusters that pin those dislocations. The team will first prepare and characterize nanoscale samples of virgin nuclear graphite in a transmission electron microscope. Additional samples will be irradiated to varying degrees at the Advanced Test Reactor (ATR) facility and similarly characterized. Researchers will record microstructures and crystal defects and suggest a mechanism for irradiation creep based on the results. In addition, the purchase of a tensile holder for a transmission electron microscope will allow, for the first time, in situ observation of creep behavior on the microstructure and crystallographic defects.

  6. L'ACTION INTERCATHODIQUE DANS LE CHAMP MAGNTIQUE (1) ; Par M. GOUY.

    E-print Network

    Paris-Sud XI, Université de

    continu et fourni par une batterie d'accu- mulateurs ou par une machine électrostatique, et le champ magné .000 gauss, courant 200 microampères, boules de 8 millimètres en aluminium. (2) On peut, par exemple

  7. Majoring in Forest Resources & Conservation

    E-print Network

    Watson, Craig A.

    Majoring in Forest Resources & Conservation Specialization: Protected Areas Management Protected Areas Management is for students interested in managing lands for conservation and restoration purposes, usually on lands owned by the government or by private conservation organizations. The program

  8. NEWS AND COMMENTARY Conservation genetics...............................................................

    E-print Network

    DeSalle, Rob

    NEWS AND COMMENTARY Conservation genetics doubt in the minds of conservation geneticists, first raised in the 1980s, that genetic considerations might be irrelevant to the conservation of species on the brink. What happens when a species goes

  9. MIDDLE PARK Conservation Action Plan

    E-print Network

    MIDDLE PARK Conservation Action Plan 2011 Update Plant Species of Focus: Kremmling milkvetch Conservation Initiative Workshop dates: June 26, 2008 and July 6, 2010 Report date: August 25, 2011 Middle Park................................................................................................................... 6 A. Conservation Targets

  10. Resource Management and Conservation Education

    ERIC Educational Resources Information Center

    Arey, David G.; Baumann, Duane D.

    1972-01-01

    The definition of conservation, the future of resource availability, the status of conservation education today are topics examined and suggestions are made on improving the content and emphasis of conservation courses. (Author)

  11. Prioritizing global conservation efforts.

    PubMed

    Wilson, Kerrie A; McBride, Marissa F; Bode, Michael; Possingham, Hugh P

    2006-03-16

    One of the most pressing issues facing the global conservation community is how to distribute limited resources between regions identified as priorities for biodiversity conservation. Approaches such as biodiversity hotspots, endemic bird areas and ecoregions are used by international organizations to prioritize conservation efforts globally. Although identifying priority regions is an important first step in solving this problem, it does not indicate how limited resources should be allocated between regions. Here we formulate how to allocate optimally conservation resources between regions identified as priorities for conservation--the 'conservation resource allocation problem'. Stochastic dynamic programming is used to find the optimal schedule of resource allocation for small problems but is intractable for large problems owing to the "curse of dimensionality". We identify two easy-to-use and easy-to-interpret heuristics that closely approximate the optimal solution. We also show the importance of both correctly formulating the problem and using information on how investment returns change through time. Our conservation resource allocation approach can be applied at any spatial scale. We demonstrate the approach with an example of optimal resource allocation among five priority regions in Wallacea and Sundaland, the transition zone between Asia and Australasia. PMID:16541073

  12. Simulation de l'accretion de glace sur un obstacle bidimensionnel par la methode des bissectrices et par la modelisation des ruisselets et des gouttes de surface

    NASA Astrophysics Data System (ADS)

    Fortin, Guy

    Le LIMA (Laboratoire International des Materiaux Antigivre) en collaboration avec le CIRA (Italian Aerospace Research Centre) a developpe un logiciel simulant l'accretion de la glace en regimes sec et humide sur un objet bidimensionnel fixe. L'approche utilisee s'appuie sur les travaux de Lozowski pour les bilans energetiques, sur une etude du comportement du film d'eau, des ruisselets et des gouttes de surface pour le calcul des rugosites et des masses d'eau residuelle, ainsi que sur une methode de bissectrice pour l'evolution de la surface de glace. La contribution du CIRA a ete de fournir le logiciel pour le calcul des ecoulements et de la captation. Le bilan energetique base sur la conservation de l'energie est la sommation de la chaleur latente de fusion, d'evaporation et de sublimation, du rechauffement adiabatique et cinetique, et des pertes de chaleur par convection et conduction, ainsi que de l'evolution thermodynamique de l'eau de son etat initial a son etat final. La densite de la glace, qui a un impact important sur la simulation, est calculee a partir d'une correlation empirique developpee avec les cylindres tournants. En se basant sur les travaux de Al-Khalil et Hansman, le comportement des gouttes en regimes sec et humide a ete decrit analytiquement, ce qui a mene a determiner la hauteur maximale que peuvent atteindre les gouttes avant mouvement. Cette hauteur, appelee hauteur de mouvement, permet de determiner l'etat de l'eau sur la surface (film, ruisselets ou gouttes), ainsi que la hauteur des rugosites lorsque l'eau existe sous forme de gouttes ou de ruisselets. La hauteur de mouvement est determinee par l'equilibre entre les forces de cisaillement, induites par les effets aerodynamiques et gravitationnels evalues pour une goutte non deformee, et la force de cisaillement, induite par la tension de surface et la deformation de la goutte. Elle a ete validee en laboratoire et la precision obtenue pour la partie aerodynamique et gravitationnelle est de 80%. L'etude de la vague qui se forme sur le film a permis de determiner la hauteur des rugosites lorsque l'eau existe sous forme de film. La masse d'eau residuelle est calculee a partir des modeles analytiques elabores selon l'etat de surface et la hauteur de mouvement. (Abstract shortened by UMI.)

  13. Article original Nombre optimal de ramets par clone

    E-print Network

    Paris-Sud XI, Université de

    Article original Nombre optimal de ramets par clone dans deux tests clonaux H Muranty, F Santi, LE 24 mai 1994 ; accepté le 13 avril 1995) Résumé — Le nombre optimal de ramets par clone dans des, de forme et de qualité du bois. Ces données provenaient d'un essai de 32 clones de merisier (Prunus

  14. Stganographie Adaptative par Oracle (ASO) Sarra Kouider2

    E-print Network

    Paris-Sud XI, Université de

    Stéganographie Adaptative par Oracle (ASO) Sarra Kouider2 Marc Chaumont1,2 William Puech2 1 continuité de ces travaux, nous proposons un algorithme de stéganographie adaptative par oracle (ASO : Adaptive Steganography by Oracle). Pour cela, nous définissons la carte de détectabi- lité en exploitant

  15. UNIVERSITE PARIS XIII Etudes de systmes atomiques par spectroscopie laser.

    E-print Network

    Paris-Sud XI, Université de

    . Les premières expériences réalisées avec un jet atomique thermique et des lasers à colorant sontUNIVERSITE PARIS XIII Etudes de systèmes atomiques par spectroscopie laser. Tests de physique fondamentale et développement d'un étalon de fréquence optique. Dossier de synthèse présenté par Mark David

  16. DE PROTECTION DE LA JEUNESSE: par Jacinthe MERCIERf

    E-print Network

    Spino, Claude

    DE PROTECTION DE LA JEUNESSE: par Jacinthe MERCIERf La procédure applicable en matière de Protection de la jeunesse soulève parfois des interrogations. Elle est régie par des dispositions qui se. Procedural matters relating to youth protection raise a number of diflculties due to the various legislative

  17. Utilisation des substrats glucoformateurs par les hpatocytes isols de mouton

    E-print Network

    Boyer, Edmond

    'activité de la pyruvate carboxylase. L'uréogenèse à partir de l'ammoniac (5 mM) est stimulée par le propiona lactate en pyruvate, soit d'une conversion très lente du pyru- vate en oxaloacétate. Le propionate est par

  18. MESURES ANGULAIRES PAR GYROMTRE LASER (*) ET PHNOMNES DE COUPLAGE

    E-print Network

    Paris-Sud XI, Université de

    résultats théoriques. Abstract. 2014 A theoretical analysis of coupling phenomena in a ring laser is given. Results of angular measurements are presented for a laser-gyro with Langmuir-Fizeau and Faraday effect737 MESURES ANGULAIRES PAR GYROMÈTRE LASER (*) ET PHÉNOMÈNES DE COUPLAGE par J. J. ROLAND et J. M

  19. EECSElectrical Engineering and Computer Sciences BERKELEY PAR LAB

    E-print Network

    California at Berkeley, University of

    -tuning is an automated, general system for performance portability across architectures, using domain-specific knowledge-level knowledge of the motif to optimize specific instantiations Where this fits in the ParLab ·ParLab is the interdisciplinary group at UC Berkeley investigating the impact of many-core parallelism ·Software stack is divided

  20. Par Pond vegetation status summer 1995 - July survey descriptive summary

    Microsoft Academic Search

    H. E. Jr. Mackey; R. S. Riley

    1995-01-01

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily

  1. Technology in water conservation 

    E-print Network

    Finch, Dr. Calvin

    2013-01-01

    2 tx H2O Summer 2013 Column by Dr. Calvin Finch, Water Conservation and Technology Center director WAT E R CONSERVATION & TECHNOLOGY CENTER Securing Our Water Future It is not unusual for individuals to describe water conservation as a... to increase the impact of rinsing and reduce water use. A homeowner who converts the plumbing in a typical pre-#29;#19;#19;#31;-built home to this technology can expect to save #31;#31;,#30;#30;#30; gallons per year in water use without a drop...

  2. Land & Water Conservation Fund

    NSDL National Science Digital Library

    In 1965, the US Congress created the Land and Water Conservation Fund (LWCF) "to preserve open space, develop recreation opportunities, and assure that all Americans have access to quality outdoor recreation." The Land and Water Conservation Fund receives $900 million annually, mainly from ocean oil drilling revenues. However, as much as 85 percent of each year's Fund is diverted for purposes other than conservation and recreation. The National Park Service provides this site, which gives technical information on the State and Federal components of the LWCF, with some historical information. For those interested in the future of natural places in this country, this site will be of great interest.

  3. Wildwatch: African Wildlife & Conservation

    NSDL National Science Digital Library

    "Wildwatch is an online publication created by CC Africa (Conservation Corporation Africa), one of Africa's most comprehensive eco-tourism companies." Visitors will find a number of interesting and informative features, such as CC Africa's monthly magazine and details of the company's six-point conservation and sustainable development model. Other items include first-hand accounts of wildlife sightings and an excellent image gallery. Some of the Web site is devoted to CC Africa's commercial ventures, but this does not detract from the overall focus on conservation and public education.

  4. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells.

    PubMed

    Sato, Yoshinori; Akitsu, Masashi; Amano, Yoshiko; Yamashita, Kazunari; Ide, Mariko; Shimada, Kyoko; Yamashita, Akio; Hirano, Hisashi; Arakawa, Noriaki; Maki, Takahisa; Hayashi, Ikuko; Ohno, Shigeo; Suzuki, Atsushi

    2013-10-15

    The establishment of epithelial polarity is tightly linked to the dramatic reorganization of microtubules (MTs) from a radial array to a vertical alignment of non-centrosomal MT bundles along the lateral membrane, and a meshwork under the apical and basal membranes. However, little is known about the underlying molecular mechanism of this polarity-dependent MT remodeling. The evolutionarily conserved cell polarity-regulating kinase PAR-1 (known as MARK in mammals), whose activity is essential for maintaining the dynamic state of MTs, has indispensable roles in promoting this process. Here, we identify a novel PAR-1-binding protein, which we call microtubule crosslinking factor 1 (MTCL1), that crosslinks MTs through its N-terminal MT-binding region and subsequent coiled-coil motifs. MTCL1 colocalized with the apicobasal MT bundles in epithelial cells, and its knockdown impaired the development of these MT bundles and the epithelial-cell-specific columnar shape. Rescue experiments revealed that the N-terminal MT-binding region was indispensable for restoring these defects of the knockdown cells. MT regrowth assays indicated that MTCL1 was not required for the initial radial growth of MTs from the apical centrosome but was essential for the accumulation of non-centrosomal MTs to the sublateral regions. Interestingly, MTCL1 recruited a subpopulation of PAR-1b (known as MARK2 in mammals) to the apicobasal MT bundles, and its interaction with PAR-1b was required for MTCL1-dependent development of the apicobasal MT bundles. These results suggest that MTCL1 mediates the epithelial-cell-specific reorganization of non-centrosomal MTs through its MT-crosslinking activity, and cooperates with PAR-1b to maintain the correct temporal balance between dynamic and stable MTs within the apicobasal MT bundles. PMID:23902687

  5. Quelques exercises 1. Soit la surface delimitee en dessous par l'axe des x au-dessus par la courbe

    E-print Network

    Katalin, Nagy

    Quelques exercises 1. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la engendr´e par la rotation de cette surface autour de l'axe des x. 2. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la courbe y = 1 x ln x , e x

  6. Quelques exercises 1. Soit la surface delimitee en dessous par l'axe des x au-dessus par la courbe

    E-print Network

    Katalin, Nagy

    Quelques exercises 1. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la surface autour de l'axe des x. 2. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la engendr´e par la rotation de cette surface autour de l'axe des x. 3. Soit la surface d´elimit´ee en

  7. Dissection of the region of Pseudomonas aeruginosa ParA that is important for dimerization and interactions with its partner ParB

    PubMed Central

    Bartosik, Aneta A.; Glabski, Krzysztof; Jecz, Paulina; Lasocki, Krzysztof; Mikosa, Malgorzata; Plochocka, Danuta; Thomas, Christopher M.

    2014-01-01

    Pseudomonas aeruginosa ParA belongs to a large subfamily of Walker-type ATPases acting as partitioning proteins in bacteria. ParA has the ability to both self-associate and interact with its partner ParB. Analysis of the deletion mutants defined the part of the protein involved in dimerization and interactions with ParB. Here, a set of ParA alanine substitution mutants in the region between E67 and L85 was created and analysed in vivo and in vitro. All mutants impaired in dimerization (substitutions at positions M74, H79, Y82 and L84) were also defective in interactions with ParB, suggesting that ParA–ParB interactions depend on the ability of ParA to dimerize. Mutants with alanine substitutions at positions E67, C68, L70, E72, F76, Q83 and L85 were not impaired in dimerization, but were defective in interactions with ParB. The dimerization interface partly overlapped the pseudo-hairpin, involved in interactions with ParB. ParA mutant derivatives tested in vitro showed no defects in ATPase activity. Two parA alleles (parA84, whose product can neither self-interact nor interact with ParB, and parA67, whose product is impaired in interactions with ParB, but not in dimerization) were introduced into the P. aeruginosa chromosome by homologous gene exchange. Both mutants showed defective separation of ParB foci, but to different extents. Only PAO1161 parA84 was visibly impaired in terms of chromosome segregation, growth rate and motility, similar to a parA-null mutant. PMID:25139949

  8. Recombination in the Human Pseudoautosomal Region PAR1

    PubMed Central

    Hinch, Anjali G.; Altemose, Nicolas; Noor, Nudrat; Donnelly, Peter; Myers, Simon R.

    2014-01-01

    The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome. PMID:25033397

  9. Surgical margins in breast conservation.

    PubMed

    Chiappa, Corrado; Rovera, Francesca; Corben, Adriana Dionigi; Fachinetti, Anna; De Berardinis, Valentina; Marchionini, Valentina; Rausei, Stefano; Boni, Luigi; Dionigi, Gianlorenzo; Dionigi, Renzo

    2013-01-01

    Breast cancer is the most common tumor affecting women worldwide. Breast-conserving therapy (BCT) followed by irradiation nowadays is the treatment of choice for early-stage disease; there is no difference in long-term survival between mastectomy and BCT combined with external radiotherapy. A positive margin is associated with increased risk of local recurrences after BCT for invasive breast cancer and ductal carcinoma in situ. The exact definition of an adequate surgical margin after breast cancer resection has long been debated among physicians and represents an area of considerable variation in clinical practice. There is a lack of standardization in the pathology methods of margin evaluation, which yields little consensus regarding what constitutes an adequate negative margin. As a consequence, patient management varies widely based on the threshold that surgeons accept for adequate margins and the subsequent need for re-excision. We analyze and discuss recent literature about this topic both from the pathological and from the surgical point of view. PMID:24380558

  10. Signal Processing 86 (2006) 38903903 A low complexity multicarrier PAR reduction approach based

    E-print Network

    Erdogan, Alper Tunga

    2006-01-01

    on subgradient optimization$ Alper Tunga Erdoganà Electrical-Electronics Engineering, Koc University power ratio (PAR); PAPR; PAR reduction; PMEPR; Subgradient; Subdifferential; Tone reservation; VDSL 1

  11. Irradiation-Induced Nanostructures

    SciTech Connect

    Birtcher, R.C.; Ewing, R.C.; Matzke, Hj.; Meldrum, A.; Newcomer, P.P.; Wang, L.M.; Wang, S.X.; Weber, W.J.

    1999-08-09

    This paper summarizes the results of the studies of the irradiation-induced formation of nanostructures, where the injected interstitials from the source of irradiation are not major components of the nanophase. This phenomena has been observed by in situ transmission electron microscopy (TEM) in a number of intermetallic compounds and ceramics during high-energy electron or ion irradiations when the ions completely penetrate through the specimen. Beginning with single crystals, electron or ion irradiation in a certain temperature range may result in nanostructures composed of amorphous domains and nanocrystals with either the original composition and crystal structure or new nanophases formed by decomposition of the target material. The phenomenon has also been observed in natural materials which have suffered irradiation from the decay of constituent radioactive elements and in nuclear reactor fuels which have been irradiated by fission neutrons and other fission products. The mechanisms involved in the process of this nanophase formation are discussed in terms of the evolution of displacement cascades, radiation-induced defect accumulation, radiation-induced segregation and phase decomposition, as well as the competition between irradiation-induced amorphization and recrystallization.

  12. COMPARAISON DE LA DTECTION DES FOYERS DE FASCIOLOSE PAR TEST ELISA SUR LACTOSRUM ET SRUM ET PAR COPROSCOPIE

    E-print Network

    Boyer, Edmond

    COMPARAISON DE LA DÉTECTION DES FOYERS DE FASCIOLOSE PAR TEST ELISA SUR LACTOSÉRUM ET SÉRUM ET PAR Cedex, France. Summary COMPARISON OF TECHNIQUES ELISA AND FECAL EXAMINATIONS TO DIAGNOSE HERDS INFEC and immunodiagnosis by ELISA technique were performed. Antibodies were searched for in the pooled milk of each herd

  13. SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation

    PubMed Central

    Liu, Xiufeng; Lan, Yan; Zhang, Di; Wang, Kai; Wang, Yao; Hua, Zi-Chun

    2014-01-01

    Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR with cytoplasm proteins. We previously used yeast two-hybrid screening to isolate several novel uPAR-interacting cytoplasmic proteins, including Sprouty1 (SPRY1), an inhibitor of the (Ras-mitogen-activated protein kinase) MAPK pathway. In this study, we show that SPRY1 interacts with uPAR and directs it toward lysosomal-mediated degradation. Overexpression of SPRY1 decreased the cell surface and cytoplasmic uPAR protein level. Moreover, SPRY1 overexpression augmented uPAR-induced cell adhesion to vitronectin as well as proliferation of cancer cells. Our results also further support the critical role of SPRY1 contribution to tumor growth. In a subcutaneous tumor model, overexpression of SPRY1 in HCT116 or A549 xenograft in athymic nude mice led to great suppression of tumor growth. These results show that SPRY1 may affect tumor cell function through direct interaction with uPAR and promote its lysosomal degradation. PMID:25520860

  14. INFECTION EXPRIMENTALE DU PORC A L'ENGRAIS PAR LE ROTAVIRUS: TUDE DE L'IMMUNIT LOCALE PAR LES

    E-print Network

    Paris-Sud XI, Université de

    INFECTION EXPÉRIMENTALE DU PORC A L'ENGRAIS PAR LE ROTAVIRUS: ÉTUDE DE L'IMMUNITÉ LOCALE PAR LES Porcine, 37380 Monnaie, France Summary EXPERIMENTAL INFECTION OF FATTENED PIGS WITH ROTAVIRUS: ANTIGENS in the faeces. Les rotavirus (reoviridae) sont associés à de nombreux syndromes entéritiques (Flewett et Woode

  15. Natural flavor conservation

    SciTech Connect

    Rothman, A.C.; Kang, K.

    1980-01-01

    It is shown that the fiats of Natural Flavor Conservation for an arbitrary U(1)-unbroken gauge theory require that all quarks of a given charge and helicity transform identically under the gauge group.

  16. Potential Conservation Laws

    E-print Network

    Michael Kunzinger; Roman O. Popovych

    2008-04-15

    We prove that potential conservation laws have characteristics depending only on local variables if and only if they are induced by local conservation laws. Therefore, characteristics of pure potential conservation laws have to essentially depend on potential variables. This statement provides a significant generalization of results of the recent paper by Bluman, Cheviakov and Ivanova [J. Math. Phys., 2006, V.47, 113505]. Moreover, we present extensions to gauged potential systems, Abelian and general coverings and general foliated systems of differential equations. An example illustrating possible applications of proved statements is considered. A special version of the Hadamard lemma for fiber bundles and the notions of weighted jet spaces are proposed as new tools for the investigation of potential conservation laws.

  17. Conservation Bentley Historical

    E-print Network

    Michigan, University of

    1981 fire of University of Michigan Economics Building #12;#12;Teaching and Outreach #12;Big Ten with compartments for map, original case and modern case #12;The Bentley Library's World Class Conservation Lab Head

  18. IUCN Conservation Programs

    ERIC Educational Resources Information Center

    Budowski, Gerardo

    1972-01-01

    Brief, but comprehensive, description of the International Union for Conservation of Nature and Natural Resources (IUCN), a non-governmental organization located in Morges, Switzerland. Presents its objectives, broad purpose and describes the specific activities of the organization. (LK)

  19. Conservation of wading birds

    USGS Publications Warehouse

    Kushlan, J.A.

    1996-01-01

    The conservation and management of wading birds has received considerable attention over the past twenty years, through research, population monitoring, habitat protection, and through activities of specialist groups devoted to all three groups, the herons, ibises and allies, and flamingos. While populations are best known in North America, greatest advances in knowledge may have come in Australasia. The status of most species and many populations is now sufficiently known to allow assessment of risk. Conservation and management techniques allow creation of global and regional action plans for conservation of many species. Global action plans are being developed, but few regional plans have been undertaken. Management of nesting sites is now particularly well appreciated. Although known in broad stroke, much remains to be learned about managing feeding habitat. Problems related to disturbance, conflict with humans, habitat loss, contaminants and other environmental stresses remain for some species and many populations. New challenges lie in creating conservation action that account for genetic stocks.

  20. Conserving Water at Home

    NSDL National Science Digital Library

    2005-12-17

    This video segment adapted from Last Oasis highlights the impact of a variety of water conservation efforts including installing low-flow toilets and planting grass that does not require a lot of water.

  1. The drought causes conservation

    NSDL National Science Digital Library

    Linda Cummer

    2007-12-12

    In this interdisciplinary, multi-day lesson students will use their knowledge of the importance of water to learn about the hydrosphere. The drought being experienced will be explored through graphs and a personal plan for water conservation.

  2. Conservation of Momentum 2

    NSDL National Science Digital Library

    Michael Horton

    2009-05-30

    This inquiry activity should be performed after students have learned about momentum, but before they learn about conservation of momentum. Students will discover that when two objects push off each other, the momentum must be equal but in opposite direct

  3. Potential For Energy Conservation

    E-print Network

    Kumar, A.

    1981-01-01

    The largest single area for industrial energy conservation is in the improvement of combustion efficiencies for heaters and boilers. A number of methods can be employed to recover heat. The most common are by use of recuperative air preheaters...

  4. Potential conservation laws

    SciTech Connect

    Kunzinger, Michael [Fakultaet fuer Mathematik, Universitaet Wien, Nordbergstrasse 15, A-1090 Wien (Austria); Popovych, Roman O. [Fakultaet fuer Mathematik, Universitaet Wien, Nordbergstrasse 15, A-1090 Wien (Austria); Institute of Mathematics, NAS of Ukraine, 3 Tereshchenkivska Str., Kyiv-4 (Ukraine)

    2008-10-15

    We prove that potential conservation laws have characteristics depending only on local variables if and only if they are induced by local conservation laws. Therefore, characteristics of pure potential conservation laws have to essentially depend on potential variables. This statement provides a significant generalization of results of the recent paper by Bluman et al. [J. Math. Phys. 47, 113505 (2006)]. Moreover, we present extensions to gauged potential systems, Abelian and general coverings, and general foliated systems of differential equations. An example illustrating possible applications of these results is given. A special version of the Hadamard lemma for fiber bundles and the notions of weighted jet spaces are proposed as new tools for the investigation of potential conservation laws.

  5. Conserving Madagascar's Freshwater Biodiversity

    NSDL National Science Digital Library

    JONATHAN P. BENSTEAD, PATRICK H. DE RHAM, JEAN-LUC GATTOLLIAT, FRANÃ?OIS-MARIE GIBON, PAUL V. LOISELLE, MICHEL SARTORI, JOHN S. SPARKS, and MELANIE L. J. STIASSNY (; )

    2003-11-01

    This peer-reviewed article from BioScience is about conserving freshwater diversity in Madagascar. The island nation of Madagascar, an international conservation priority, is now also recognized as a global hotspot for freshwater biodiversity. Three emerging characteristics of Madagascar's threatened freshwater biota deserve increased attention from the scientific and conservation communities. First, species richness is not low, as was once assumed for both the freshwater fishes and the invertebrates. Second, many species are restricted to a specific region or even to single river basins. Often these species are also limited to streams or rivers draining primary forest habitat. Finally, many of the island's freshwater fishes are basal taxa, having diverged earlier than any other extant members of their clade. As such, these taxa assume disproportional phylogenetic importance. In the face of ongoing environmental threats, links among microendemism, forest stream specialization, and basal phylogenetic position highlight the importance and vulnerability of these species and provide a powerful incentive for immediate conservation action.

  6. A time-resolved current method for the investigation of charging ability of insulators under electron beam irradiation

    Microsoft Academic Search

    Z. G. Song; C. K. Ong; H. Gong

    1996-01-01

    In the present article, a convenient method for the direct measurement of the displacement current caused by electron trapping is developed to measure the trapped charge in insulators under electron beam irradiation from a scanning electron microscope. The trapping process during electron beam irradiation can be directly observed by this method. By using the conservation of current, a macroscopic formula

  7. Gamma irradiation facilities

    NASA Astrophysics Data System (ADS)

    Tamura, Naoyuki

    A review is presented on the status and problem of gamma irradiation facilities for radiation processing. Requirements for the radioisotope source in the radiation processing and its comparison with electron accelerator are discussed. The gamma radioisotope source has speciality in the process of thicker products and source design, though it is inferior on the cost of radiation output. Problems on irradiation facilities such as storage and transportation of the source, the damage of materials used, and dosimetry are discussed. The gamma irradiation facilities for the radiation processing in Japan are introduced.

  8. Maladie de Horton révélée par une dyspnée

    PubMed Central

    Mahfoudhi, Madiha; Mamlouk, Habiba; Turki, Sami; Kheder, Adel

    2015-01-01

    Les manifestations pleuro-pulmonaires de la maladie de Horton sont rares et peu connues. Elles peuvent être inaugurales, à l'origine d'un retard à la prise en charge si elles sont méconnues. Il s'agissait d'un patient âgé de 75 ans, admis pour une dyspnée, une toux chronique et une fièvre. Il a reçu une antibiothérapie et a bénéficié d'une fibroscopie bronchique avec lavage broncho-alvéolaire à la recherche d'un germe, qui a révélé plutôt, une alvéolite lymphocytaire. L’évolution était marquée par la persistance des signes cliniques et du syndrome inflammatoire biologique. Un angio-scanner thoracique et une échographie cardiaque étaient sans anomalies. Une origine cardiaque, musculaire, hématologique, néoplasique, vasculaire ou métabolique de la dyspnée a été éliminée. Une maladie de Horton a été évoquée. La biopsie de l'artère temporale a confirmé le diagnostic d'une maladie de Horton. L’évolution sous corticothérapie était marquée par la disparition des signes cliniques et biologiques. Les manifestations pleuro-pulmonaires au cours de la maladie de Horton sont rares, et classiquement, rarement révélatrices de la maladie. La dyspnée peut initialement égarer le diagnostic vers d'autres étiologies notamment infectieuses. Le but de ce travail est d'insister sur le fait que la connaissance de ces différentes manifestations respiratoires au cours de la maladie de Horton (toux persistante, dyspnée, épanchement pleural) est utile au clinicien afin de prescrire une corticothérapie, chez un sujet le plus souvent âgé ayant un état fébrile et inflammatoire prolongé, permettant ainsi d’éviter l'apparition de complications. PMID:26161171

  9. Conservation Biology Institute

    NSDL National Science Digital Library

    The Conservation Biology Institute (CBI), a non-profit organization founded in 1997, is active in three primary areas related to conservation biology - applied research, education, and professional services. Through its research - alone or in collaboration with others - CBI actively seeks to develop new conservation tools, techniques, and analyses that can be used to better address a wide range of ecological concerns from endangered species protection to regional conservation planning. Based on a combination of field-based biology and computer mapping technologies (i.e., remote sensing and geographic information systems), CBIs primary research areas include: forest, aquatic, and watershed assessments, local and regional conservation planning, endangered species research and management, ecosystem monitoring, and carnivore conservation. Their formal education program, still in development, currently consists of five basic subdivisions (or program areas) including internships/ fellowships, education materials, college courses, short courses, and workshops/guest lectures. CBIs professional services are conducted alone or in collaboration with outside organizations and include: biological surveys and consulting, geographical information system (GIS) mapping services, as well as scientific reviews and white papers.

  10. SPECIAL OFFER Conservation Science Trade-offs in Conservation

    E-print Network

    SPECIAL OFFER Conservation Science Trade-offs in Conservation Deciding What to Save NIGEL LEADER that surround making decisions about which species and biogeographic areas to prioritise for conservation of the Conservation Science and Practice book series Also available online. For further information, visit: www

  11. Hyperbolic Conservation Laws The 1D conservation law

    E-print Network

    Gardner, Carl

    Hyperbolic Conservation Laws The 1D conservation law wt + f(w)x = 0 (where w and f have m of linearly independent eigenvectors). Then solutions to the conservation law can be viewed in terms to form a complete linearly independent set, and the conservation law is called strictly hyperbolic

  12. A CONSERVATIVE FRONT TRACKING HETHOD FOR HYPERBOLIC CONSERVATION LAWS

    E-print Network

    UCRL-97200 PREPRINT A CONSERVATIVE FRONT TRACKING HETHOD FOR HYPERBOLIC CONSERVATION LAWS I FRONT TRACKING METHOD FOR HYPERBOLIC CONSERVATION LAWS I-Liang Chern InstibJte of Mathematics Academia finite difference method for computing discontinuous solutions to systems of hyperbolic conservation laws

  13. Reconstituting ParA/ParB-mediated transport of DNA cargo.

    PubMed

    Vecchiarelli, Anthony G; Taylor, James A; Mizuuchi, Kiyoshi

    2015-01-01

    Protein gradients play key roles in subcellular spatial organization. In bacteria, ParA adenosine triphosphatases, or ATPases, form dynamic gradients on the nucleoid surface, which imparts positional information for the segregation, transport, and positioning of chromosomes, plasmids, and large protein assemblies. Despite the apparent simplicity of these minimal and self-organizing systems, the mechanism remains unclear. The small size of bacteria along with the number of physical and biochemical processes involved in subcellular organization makes it difficult to study these systems under controlled conditions in vivo. We developed a cell-free reconstitution technique that allows for the visualization of ParA-mediated cargo transport on a DNA carpet, which acts as a biomimetic of the nucleoid surface. Here, we present methods to express, purify, and visualize the dynamic properties of the SopABC system from F plasmid, considered a paradigm for the study of ParA-type systems. We hope similar cell-free studies will be used to address the biochemical and biophysical underpinnings of this ubiquitous transport scheme in bacteria. PMID:25997351

  14. Protection contre l'épilation par la cystamine après irradiation locale chez le rat

    Microsoft Academic Search

    P. Caneghem; E. GLAVA; T. TRAJKOV

    1964-01-01

    Zusammenfassung An Cystamin-injizierten Ratten (i.p.) wurde das Ausmass der Schutzwirkung, in zeitlicher Abhängigkeit, bei lokaler Röntgenbestrahlung, auf das Haarwachstum untersucht. Eine maximale Schutzwirkung wurde nach 10 min gefunden. Sie nimmt von da an langsam ab und ist selbst 60 min nach der Cystamininjektion noch nachweisbar.

  15. Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells.

    PubMed

    Shahab, Jaffer; Tiwari, Manu D; Honemann-Capito, Mona; Krahn, Michael P; Wodarz, Andreas

    2015-01-01

    Apico-basal polarity is the defining characteristic of epithelial cells. In Drosophila, apical membrane identity is established and regulated through interactions between the highly conserved Par complex (Bazooka/Par3, atypical protein kinase C and Par6), and the Crumbs complex (Crumbs, Stardust and PATJ). It has been proposed that Bazooka operates at the top of a genetic hierarchy in the establishment and maintenance of apico-basal polarity. However, there is still ambiguity over the correct sequence of events and cross-talk with other pathways during this process. In this study, we reassess this issue by comparing the phenotypes of the commonly used baz(4) and baz(815-8) alleles with those of the so far uncharacterized baz(XR11) and baz(EH747) null alleles in different Drosophila epithelia. While all these baz alleles display identical phenotypes during embryonic epithelial development, we observe strong discrepancies in the severity and penetrance of polarity defects in the follicular epithelium: polarity is mostly normal in baz(EH747) and baz(XR11) while baz(4) and baz(815) (-8) show loss of polarity, severe multilayering and loss of epithelial integrity throughout the clones. Further analysis reveals that the chromosomes carrying the baz(4) and baz(815-8) alleles may contain additional mutations that enhance the true baz loss-of-function phenotype in the follicular epithelium. This study clearly shows that Baz is dispensable for the regulation of polarity in the follicular epithelium, and that the requirement for key regulators of cell polarity is highly dependent on developmental context and cell type. PMID:25770183

  16. Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells

    PubMed Central

    Shahab, Jaffer; Tiwari, Manu D.; Honemann-Capito, Mona; Krahn, Michael P.; Wodarz, Andreas

    2015-01-01

    Apico-basal polarity is the defining characteristic of epithelial cells. In Drosophila, apical membrane identity is established and regulated through interactions between the highly conserved Par complex (Bazooka/Par3, atypical protein kinase C and Par6), and the Crumbs complex (Crumbs, Stardust and PATJ). It has been proposed that Bazooka operates at the top of a genetic hierarchy in the establishment and maintenance of apico-basal polarity. However, there is still ambiguity over the correct sequence of events and cross-talk with other pathways during this process. In this study, we reassess this issue by comparing the phenotypes of the commonly used baz4 and baz815-8 alleles with those of the so far uncharacterized bazXR11 and bazEH747 null alleles in different Drosophila epithelia. While all these baz alleles display identical phenotypes during embryonic epithelial development, we observe strong discrepancies in the severity and penetrance of polarity defects in the follicular epithelium: polarity is mostly normal in bazEH747 and bazXR11 while baz4 and baz815-8 show loss of polarity, severe multilayering and loss of epithelial integrity throughout the clones. Further analysis reveals that the chromosomes carrying the baz4 and baz815-8 alleles may contain additional mutations that enhance the true baz loss-of-function phenotype in the follicular epithelium. This study clearly shows that Baz is dispensable for the regulation of polarity in the follicular epithelium, and that the requirement for key regulators of cell polarity is highly dependent on developmental context and cell type. PMID:25770183

  17. Food irradiation in perspective

    NASA Astrophysics Data System (ADS)

    Henon, Y. M.

    1995-02-01

    Food irradiation already has a long history of hopes and disappointments. Nowhere in the world it plays the role that it should have, including in the much needed prevention of foodborne diseases. Irradiated food sold well wherever consumers were given a chance to buy them. Differences between national regulations do not allow the international trade of irradiated foods. While in many countries food irradiation is still illegal, in most others it is regulated as a food additive and based on the knowledge of the sixties. Until 1980, wholesomeness was the big issue. Then the "prerequisite" became detection methods. Large amounts of money have been spent to design and validate tests which, in fact, aim at enforcing unjustified restrictions on the use of the process. In spite of all the difficulties, it is believed that the efforts of various UN organizations and a growing legitimate demand for food safety should in the end lead to recognition and acceptance.

  18. Conservation Kickstart- Catalyzing Conservation Initiatives Worldwide

    NASA Astrophysics Data System (ADS)

    Treinish, G.

    2014-12-01

    Adventurers and Scientists for Conservation (ASC) is a nonprofit organization that collects environmental data to catalyze conservation initiatives worldwide. Adventure athletes have the skills and motivation to reach the most remote corners of the world. ASC utilizes those skills to provide the scientific community with data while providing the outdoor community with purpose beyond the personal high of reaching a summit or rowing across an ocean. We carefully select projects, choosing partnerships that will maximize the impact of ASC volunteers. Each project must have a clear path to a tangible conservation outcome and demonstrate a clear need for our brand of volunteers. We partner with government agencies, universities, and independant reseachers to kickstart data collection efforts around the world. Last year, through a partnership with the Olympic National Forest, 20 volunteers from the Seattle area set up and monitored camera traps in an effort to survey for costal Pacific marten. Our work led to the species' listing as "critically imperiled" with NatureServe. A partnership with the inaugural Great Pacific Race, engaging trans-Pacific rowing teams, searched for microplastics in the Pacific Ocean as part of our ongoing microplastics campaign. In a multi-year partnership with the American Prairie Reserve (APR), ASC volunteer crews live and work on the Reserve collecting wildlife data year round. The data we obtain directly informs the Reserve's wildlife management decisions. On this project, our crews have safely and effectively navigated temperature extremes from -30 degrees to 100+ degrees while traveling in a remote location. We are currently scouting projects in the Okavango Delta of Botswana and the rainforest of Suriname where we will be able to cover large amounts of area in a short periord of time. ASC is at the crossroads of the adventure and coservation science communities. Our approach of answering specific questions by using highly skilled and motivate volunteers ensures that we are able to collect quality data, cost effectively, and in a fraction of the traditional timeframe.

  19. Conservation Strategy for Sable Island

    E-print Network

    Jones, Ian L.

    Towards a Conservation Strategy for Sable Island Environment Canada, Canadian Wildlife Service, Atlantic Region #12;SABLE ISLAND CONSERVATION STRATEGY page - i March, 1998 A CONSERVATION STRATEGY FOR SABLE ISLAND PREPARED BY This Conservation Strategy for Sable Island was prepared for Environment Canada

  20. Conservation Issues Raised for the

    E-print Network

    Northwest Power and Conservation Council Issues Raised for the Sixth Power Plan Power Committee Web Meeting June 30, 2009 Northwest Power and Conservation Council Conservation Targets · Problem ­ Are 5-Year conservation targets too high? · Issue for Bonneville and the Public Utilities ­ Are targets being driven

  1. Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate.

    PubMed

    Vorhagen, Susanne; Niessen, Carien M

    2014-11-01

    Oriented cell division is a key regulator of tissue architecture and crucial for morphogenesis and homeostasis. Balanced regulation of proliferation and differentiation is an essential property of tissues not only to drive morphogenesis but also to maintain and restore homeostasis. In many tissues orientation of cell division is coupled to the regulation of differentiation producing daughters with similar (symmetric cell division, SCD) or differential fate (asymmetric cell division, ACD). This allows the organism to generate cell lineage diversity from a small pool of stem and progenitor cells. Division orientation and/or the ratio of ACD/SCD need to be tightly controlled. Loss of orientation or an altered ratio can promote overgrowth, alter tissue architecture and induce aberrant differentiation, and have been linked to morphogenetic diseases, cancer and aging. A key requirement for oriented division is the presence of a polarity axis, which can be established through cell intrinsic and/or extrinsic signals. Polarity proteins translate such internal and external cues to drive polarization. In this review we will focus on the role of the polarity complex aPKC/Par3/Par6 in the regulation of division orientation and cell fate in different mammalian epithelia. We will compare the conserved function of this complex in mitotic spindle orientation and distribution of cell fate determinants and highlight common and differential mechanisms in which this complex is used by tissues to adapt division orientation and cell fate to the specific properties of the epithelium. PMID:25128813

  2. Blood irradiation: Rationale and technique

    SciTech Connect

    Lewis, M.C. (Savannah Regional Center for Cancer Care, Memorial Medical Center, GA (USA))

    1990-01-01

    Upon request by the local American Red Cross, the Savannah Regional Center for Cancer Care irradiates whole blood or blood components to prevent post-transfusion graft-versus-host reaction in patients who have severely depressed immune systems. The rationale for blood irradiation, the total absorbed dose, the type of patients who require irradiated blood, and the regulations that apply to irradiated blood are presented. A method of irradiating blood using a linear accelerator is described.

  3. CCD fiber optic spectrometer for the measurement of spectral irradiance

    NASA Astrophysics Data System (ADS)

    Morley, J. U.; McArthur, L. J. B.; Halliwell, D.; Poissant, Y.; Pelland, S.

    2010-08-01

    Recent technological advancements have made CCD spectrometers an increasingly suitable alternative to traditional monochromator-based instrumentation. The authors have developed instrumentation for the near instantaneous measurement of spectral global, direct, diffuse, reflected and southward-tilted irradiances. The system uses an AvaSpec2048TEC-2 - a dual channel thermo-electric-cooled fiber optic spectrometer from Avantes Inc. Each channel has a 2048-pixel linear array detector and the system achieves a spectral resolution of 0.0007 ?m (FWHM) over the range 0.241-1.1 ?m. The system also includes sensor heads, fiber optic cables and a multiplexer. Two types of sensor heads have been developed: a pyrheliometer configuration for direct beam, and a pyranometer configuration for global, diffuse, reflected and tilted measurements. Calibration uses a system of standard light sources. Cosine errors inherent to the spectralon diffusers have been characterized and corrections are applied to data from each sensor head. Accuracy of global irradiance is examined by comparing measurements against global photosynthetically active radiation (PAR) (0.395 - 0.695 ?m) from Eppley red and green dome pyranometers. PAR daily totals (MJ/m2/day) and one minute averages (W/m2) are compared for 35 days in 2009 and daily totals are within +/- 10% from June to October.

  4. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    PubMed Central

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  5. The Data Conservancy

    NASA Astrophysics Data System (ADS)

    Choudhury, S.; Duerr, R. E.

    2009-12-01

    NSF's Sustainable Digital Data Preservation and Access Network Partners program is an ambitious attempt to integrate a wide variety of expertise and infrastructure into a network for providing "reliable digital preservation, access, integration, and analysis capabilities for science." One of the first two DataNet award recipients, the Data Conservancy, is itself a network of widely diverse partners led by the libraries at the Johns Hopkins University. The Data Conservancy is built on existing exemplar scientific projects, communities, and virtual organizations that have deep engagement with their user communities, and extensive experience with large-scale distributed system development. Data Conservancy members embrace a shared vision that data curation is not an end, but rather a means to collect, organize, validate, and preserve data needed to address the grand research challenges that face society. Data Conservancy members holdings encompass the entire range of earth, life, and space science data. New to the Data Conservancy is the concept that University libraries will be part of the distributed network of data centers and that data science will become a path in the library and information science curricula. As noted by Winston Tabb (JHU Dean of Libraries) "Data Centers are the new library stacks."

  6. Creative Conservation Communication

    NASA Astrophysics Data System (ADS)

    Houston, Jason

    2015-04-01

    I am a fellow with the International League of Conservation photographers (iLCP) and have been focused on photographing conservation dynamics at the intersection of social and environmental issues for a decade. Subjects have included traditional concerns such as deforestation, water conservation, endangered species, and fisheries. However, I rarely make photographs of the traditional nature, wildlife, landscapes, or environmental atrocities that most people think of when they think about environmentalism. Instead, I photograph people and how they live on the planet, as I believe passionately that without also considering social and cultural concerns, we will not be able to effectively and sustainably do conservation work or achieve positive environmental change. My presentation will share recent photography projects on forest conservation in Indonesian Borneo and fisheries management in Central America where I used a 'stakeholder profile-based' process to broadly survey the complexity of the issues while also making personal connections for these projects' diverse audiences. Through these case studies I will explore the opportunities and challenges of combining the authenticity, accuracy, and scientific validity of journalistic and documentary work with the emotional impact of the conventions of art and storytelling.

  7. Wilderness and biodiversity conservation

    PubMed Central

    Mittermeier, R. A.; Mittermeier, C. G.; Brooks, T. M.; Pilgrim, J. D.; Konstant, W. R.; da Fonseca, G. A. B.; Kormos, C.

    2003-01-01

    Human pressure threatens many species and ecosystems, so conservation efforts necessarily prioritize saving them. However, conservation should clearly be proactive wherever possible. In this article, we assess the biodiversity conservation value, and specifically the irreplaceability in terms of species endemism, of those of the planet's ecosystems that remain intact. We find that 24 wilderness areas, all > 1 million hectares, are > 70% intact and have human densities of less than or equal to five people per km2. This wilderness covers 44% of all land but is inhabited by only 3% of people. Given this sparse population, wilderness conservation is cost-effective, especially if ecosystem service value is incorporated. Soberingly, however, most wilderness is not speciose: only 18% of plants and 10% of terrestrial vertebrates are endemic to individual wildernesses, the majority restricted to Amazonia, Congo, New Guinea, the Miombo-Mopane woodlands, and the North American deserts. Global conservation strategy must target these five wildernesses while continuing to prioritize threatened biodiversity hotspots. PMID:12930898

  8. 77 FR 74167 - Information Collection Request: Highly Erodible Land Conservation and Wetland Conservation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ...Highly Erodible Land Conservation and Wetland Conservation AGENCIES: Farm Service Agency...Highly Erodible Land Conservation and Wetland Conservation certification requirements...Highly Erodible Land Conservation and Wetland Conservation Certification. OMB...

  9. Irradiance optimization of outdoor microalgal cultures using solar tracked photobioreactors.

    PubMed

    Hindersin, Stefan; Leupold, Marco; Kerner, Martin; Hanelt, Dieter

    2013-03-01

    Photosynthetic activity and temperature regulation of microalgal cultures (Chlorella vulgaris and Scenedesmus obliquus) under different irradiances controlled by a solar tracker and different cell densities were studied in outdoor flat panel photobioreactors. An automated process control unit regulated light and temperature as well as pH value and nutrient concentration in the culture medium. CO2 was supplied using flue gas from an attached combined block heat and power station. Photosynthetic activity was determined by pulse amplitude modulation fluorometry. Compared to the horizontal irradiance of 55 mol photons m(-2) d(-1) on a clear day, the solar tracked photobioreactors enabled a decrease and increase in the overall light absorption from 19 mol photons m(-2) d(-1) (by rotation out of direct irradiance) to 79 mol photons m(-2) d(-1) (following the position of the sun). At biomass concentrations below 1.1 g cell dry weight (CDW) L(-1), photoinhibition of about 35 % occurred at irradiances of ?1,000 ?mol photons m(-2) s(-1) photosynthetic active radiation (PAR). Using solar tracked photobioreactors, photoinhibition can be reduced and at optimum biomass concentration (?2.3 g CDW L(-1)), the culture was irradiated up to 2,000 ?mol photons m(-2) s(-1) to overcome light limitation with biomass yields of 0.7 g CDW mol photons(-1) and high photosynthetic activities indicated by an effective quantum yield of 0.68 and a maximum quantum yield of 0.80 (F v/F m). Overheating due to high irradiance was avoided by turning the PBR out of the sun or using a cooling system, which maintained the temperature close to the species-specific temperature optima. PMID:22847362

  10. EPA and Bird Conservation

    NSDL National Science Digital Library

    Although wildlife management is not the central focus of the Environmental Protection Agency's (EPA) mission, numerous EPA programs complement and support efforts to conserve birds and their habitats. To that end, the Office of Water at the EPA has launched this new Website to point interested users towards related EPA (and other) programs. From wetlands to water quality, the specific EPA sites highlighted here cover topics that are bird-relevant in subject (e.g., wetlands, coasts) or geographical (e.g., Great Lakes, Gulf of Mexico) context. Four main sections form the heart of the site: Overview, Bird Conservation Initiatives, Related EPA Programs, and What You Can Do. In each section, summary information and a careful selection of related resources are provided. Students of bird conservation will find this site particularly helpful, especially those interested in relevant federal programs.

  11. Solar radiation (PAR and UVA) and water temperature in relation to biochemical performance of Gelidium corneum (Gelidiales, Rhodophyta) in subtidal bottoms off the Basque coast

    NASA Astrophysics Data System (ADS)

    Quintano, Endika; Ganzedo, Unai; Díez, Isabel; Figueroa, Félix L.; Gorostiaga, José M.

    2013-10-01

    Gelidium corneum (Hudson) J.V. Lamouroux is a very important primary producer in the Cantabrian coastal ecosystem. Some local declines in their populations have been recently detected in the Basque coast. Occurrences of yellowing and an unusual branch breakdown pattern have also been reported for some G. corneum populations. In order to gain further insight into those environmental stressors operating at a local scale, here we investigate if shallow subtidal populations of G. corneum living under potentially different conditions of irradiance (PAR and UVA) and water temperature exhibit differences in some biochemical indicators of stress, namely C:N, antioxidant activity (radical cation of 2,2?-azino-bis (3-ethylbenzothiazoline-6-sulfonate); ABTS+ assay) and mycosporine-like amino acids (MAAs) (Asterine 330 and Palythine). We hypothesised that G. corneum subjected to higher ambient levels of irradiance and water temperature would show higher C:N ratios, lower antioxidant activity and higher MAA concentrations. Our results partially support this hypothesis. We found that G. corneum exposed to increased levels of irradiance (PAR, UVA) exhibited greater C:N ratios and lower antioxidant activity (higher IC50), whereas no relationship was found regarding MAAs. No differences in biochemical performance in relation to temperature were detected among G. corneum exposed to comparable high light. Similarly, G. corneum growing under lower UVA radiation levels showed no differences in any of the measured biochemical variables with regard to PAR and water temperature. These findings suggest that, among the environmental factors examined, UVA radiation may be an important driver in regulating the along-shore variation in G. corneum biochemical performance. Therefore, the role of irradiance, especially UV radiation, in potential future alterations in Cantabrian G. corneum populations cannot be ruled out as a potential underlying factor.

  12. 1 Cours de M.RUMIN rcrit par J.KULCSAR Chapitre IV

    E-print Network

    Rumin, Michel

    1 Cours de M.RUMIN réécrit par J.KULCSAR Chapitre IV Bases et dimension d'un espace vectoriel. Démonstration : () : est génératrice par hypothèse. est elle libre ? Soient tels que . #12;2 Cours de M.RUMIN vecteurs. #12;3 Cours de M.RUMIN réécrit par J.KULCSAR - Base d'un plan de défini par une équation

  13. Temprature de surface du Plateau Antarctique Cadre de simulations par le modle de neige Crocus

    E-print Network

    Ribes, Aurélien

    Température de surface du Plateau Antarctique Cadre de simulations par le modèle de neige Crocus BSRN (PNRA ENEA / ISAC-CNR) #12;5 Modèle de neige Crocus (Brun et al., 1992, Vionnet et al., 2012) Ts surface à Dôme C : - par Crocus forcé par les conditions météorologiques observées in-situ - par Crocus en

  14. The signaling adapter Gab1 regulates cell polarity by acting as a PAR protein scaffold

    PubMed Central

    Yang, Ziqiang; Xue, Bin; Umitsu, Masataka; Ikura, Mitsuhiko; Muthuswamy, Senthil K.; Neel, Benjamin G.

    2012-01-01

    Summary Cell polarity plays a key role in development and is disrupted in tumors, yet the molecules and mechanisms that regulate polarity remain poorly defined. We found that the scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. GAB1 binds PAR1 and enhances its kinase activity. GAB1 brings PAR1 and PAR3 into a transient complex, stimulating PAR3 phosphorylation by PAR1. GAB1 and PAR6 bind the PAR3 PDZ1 domain and thereby compete for PAR3 binding. Consequently, GAB1 depletion causes PAR3 hypo-phosphorylation and increases PAR3/PAR6 complex formation, resulting in accelerated and enhanced tight junction formation, increased trans-epithelial resistance and lateral domain shortening. Conversely, GAB1 over-expression, in a PAR1/PAR3-dependent manner, disrupts epithelial apical-basal polarity, promotes multi-lumen cyst formation, and enhances growth factor-induced epithelial cell scattering. Our results identify GAB1 as a novel negative regulator of epithelial cell polarity that functions as a scaffold for modulating PAR protein complexes on the lateral membrane. PMID:22883624

  15. JOURNAL DE PHYSIQUE Colloque C6, supplkment au no 12, Tome 38, Dkcembre 1977, page C6-35 EXPERIMENTS ON INTENSE LASER IRRADIATION OF PLASMAS

    E-print Network

    Paris-Sud XI, Université de

    made with respect to beam quality and reproducibility of lasers. With the Nd-glass laser self-focusing-35 EXPERIMENTS ON INTENSE LASER IRRADIATION OF PLASMAS R. SIGEL Projektgruppe fur Laserforschung der Max-Planck-Gesellschaft, D-8046 Garching, FRG Rhumb.-Avec son application possible a la fusion par laser, la production de

  16. Conservation of Mass

    NSDL National Science Digital Library

    Perkins School for the Blind

    2012-07-11

    This activity was designed for blind learners, but all types of learners can participate to learn about conservation of gas. This is one of the classic experiments using baking soda and vinegar. The expansion of a balloon with gas provides a tactile experience as the gas is captured rather than being released into the air. The evidence of conservation of mass is supported by the collection of data, by weighing the masses of the reactants before and after the experiment. Learners with visual impairments and sighted students can also learn that matter is neither created nor destroyed during a chemical change.

  17. Energy conservation in infants.

    PubMed

    Blass, Elliott

    2015-08-01

    Energy acquisition through suckling has been widely studied in rat and human infants. Processes mediating energy conservation, however, have not received the attention that they deserve. This essay, in honor of Professor Jerry Hogan, discusses parallel behaviors used by rat and human mothers to minimize energy loss in their offspring. Parallel mechanisms underlying energy preservation have been identified in rats and humans, suggesting phylogenetic conservation and possibly continuity. This article is part of a Special Issue entitled: In Honor of Jerry Hogan. PMID:25643950

  18. View from northeast to southwest of PAR site sentry station; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from northeast to southwest of PAR site sentry station; formerly the bachelor's enlisted men's quarter (BEQ) - Stanley R. Mickelsen Safeguard Complex, Sentry Station, North of Second Avenue & West of Electrical Switch Station No. 2, Nekoma, Cavalier County, ND

  19. View from southeast to northwest of PAR site bachelor officers' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from southeast to northwest of PAR site bachelor officers' quarters - Stanley R. Mickelsen Safeguard Complex, Bachelor Officers' Quarters, North of Second Avenue; South of Metal & Woodworking Shop No. 706, Nekoma, Cavalier County, ND

  20. PARS: Programs for Analysis and Resizing of Structures, user manual

    NASA Technical Reports Server (NTRS)

    Haftka, R. T.; Prasad, B.; Tsach, U.

    1979-01-01

    PARS processors and their use, flutter analysis, sensitivity analysis for stresses, and resizing are presented. Design variable definition and interface with finite element model, static constraints and their derivatives, flutter derivatives, and optimization are discussed.

  1. Ordonnancement de threads dirig par la mmoire sur architecture NUMA

    E-print Network

    Boyer, Edmond

    . Bien que la finesse de gravure continue de progresser, réduisant de plus en plus la taille des circuits'espace offert par une gravure plus fine pour ajouter des unités fonc- tionnelles ou des niveaux de caches

  2. Activation des cellules Natural Killer par les endocannabinodes

    E-print Network

    Activation des cellules Natural Killer par les endocannabinoïdes Anandamide et 2-Arachidonoyl Abréviations 6 Introduction 8 1. Les cellules Natural Killer 8 1.1. Les différents types de cellules NK : CD56

  3. Par Alain Ricard Explorateurs europens en Afrique noire

    E-print Network

    Paris-Sud XI, Université de

    ; les frères Lander n'ont pas découvert le Niger, mais ils ont situé son embouchure, établissant un lien entre un delta envahi par la mangrove et les " huiles " et un grand fleuve paresseux qui coulait en

  4. Un lymphangiome kystique rétropéritonéal révélé par des coliques néphrétiques

    PubMed Central

    El anzaoui, Jihad; Ghoundale, Omar; Touiti, Driss; El barni, Rachid; Mejdane, Abdelhadi; Fihri, Jawad Fassi; Lahkim, Mohammed; Achour, Abdsamad

    2015-01-01

    Résumé Le lymphangiome kystique (LK) est une tumeur rare des voies lymphatiques caractérisée par son évolution bénigne. La fréquence de la localisation rétropéritonéale est controversée. La découverte se fait le plus souvent dès l’enfance. L’évolution de la maladie peut être marquée par des complications graves, notamment compressives. Nous faisons état de l’observation médicale d’une femme de 30 ans chez qui l’on a découvert, à la suite de l’apparition de coliques néphrétiques récidivantes, un LK énorme occupant tout l’espace rétropéritonéal droit. Le diagnostic a été évoqué par l’urotomodensitométrie et confirmé par l’histologie. L’évolution après exérèse chirurgicale de la masse a été favorable, avec la disparition des coliques néphrétiques. PMID:25844099

  5. Les taxis pigs par 36 000 communes Richard Darbra

    E-print Network

    Paris-Sud XI, Université de

    non emergency patient transport or from adopting new technologies like smartphone malades ou d'adopter les nouvelles technologies de réservation par applications de téléphonie mobile. Abstract "The French taxis trapped by 36,000 local governments

  6. Discuss the testing problems of ultraviolet irradiance meters

    NASA Astrophysics Data System (ADS)

    Ye, Jun'an; Lin, Fangsheng

    2014-09-01

    Ultraviolet irradiance meters are widely used in many areas such as medical treatment, epidemic prevention, energy conservation and environment protection, computers, manufacture, electronics, ageing of material and photo-electric effect, for testing ultraviolet irradiance intensity. So the accuracy of value directly affects the sterile control in hospital, treatment, the prevention level of CDC and the control accuracy of curing and aging in manufacturing industry etc. Because the display of ultraviolet irradiance meters is easy to change, in order to ensure the accuracy, it needs to be recalibrated after being used period of time. By the comparison with the standard ultraviolet irradiance meters, which are traceable to national benchmarks, we can acquire the correction factor to ensure that the instruments working under accurate status and giving the accurate measured data. This leads to an important question: what kind of testing device is more accurate and reliable? This article introduces the testing method and problems of the current testing device for ultraviolet irradiance meters. In order to solve these problems, we have developed a new three-dimensional automatic testing device. We introduce structure and working principle of this system and compare the advantages and disadvantages of two devices. In addition, we analyses the errors in the testing of ultraviolet irradiance meters.

  7. cole doctorale EMMA Lorraine Nattribu par la bibliothque

    E-print Network

    Boyer, Edmond

    �cole doctorale EMMA Lorraine N°attribué par la bibliothèque THESE Présentée et soutenue Lorraine Spécialité "Mécanique et �nergétique" Par Nadhir LEBAAL Optimisation de la tête d'extrusion pour R&D Suisse. Institut National Polytechnique de Lorraine-INPL Nancy 2, Avenue de la Forêt de Haye

  8. StePar: an automatic code for stellar parameter determination

    NASA Astrophysics Data System (ADS)

    Tabernero, H. M.; González Hernández, J. I.; Montes, D.

    2013-05-01

    We introduce a new automatic code (StePar) for determinig stellar atmospheric parameters (T_{eff}, log{g}, ? and [Fe/H]) in an automated way. StePar employs the 2002 version of the MOOG code (Sneden 1973) and a grid of Kurucz ATLAS9 plane-paralell model atmospheres (Kurucz 1993). The atmospheric parameters are obtained from the EWs of 263 Fe I and 36 Fe II lines (obtained from Sousa et al. 2008, A&A, 487, 373) iterating until the excitation and ionization equilibrium are fullfilled. StePar uses a Downhill Simplex method that minimizes a quadratic form composed by the excitation and ionization equilibrium conditions. Atmospheric parameters determined by StePar are independent of the stellar parameters initial-guess for the problem star, therefore we employ the canonical solar values as initial input. StePar can only deal with FGK stars from F6 to K4, also it can not work with fast rotators, veiled spectra, very metal poor stars or Signal to noise ratio below 30. Optionally StePar can operate with MARCS models (Gustafson et al. 2008, A&A, 486, 951) instead of Kurucz ATLAS9 models, additionally Turbospectrum (Alvarez & Plez 1998, A&A, 330, 1109) can replace the MOOG code and play its role during the parameter determination. StePar has been used to determine stellar parameters for some studies (Tabernero et al. 2012, A&A, 547, A13; Wisniewski et al. 2012, AJ, 143, 107). In addition StePar is being used to obtain parameters for FGK stars from the GAIA-ESO Survey.

  9. Another application for trellis shaping: PAR reduction for DMT (OFDM)

    Microsoft Academic Search

    Werner Henkel; Björn Wagner

    2000-01-01

    A bound for the possible reduction of the peak-to-average ratio (PAR) dependent on the rate as well as possible practical procedures are presented. The idea of trellis shaping, originally used to minimize average transmit power in single-carrier systems, is applied to the problem of PAR reduction in multicarrier transmission. Its impact, as a function of code rate, as well as

  10. Par reduction in ofdm via active constellation extension

    Microsoft Academic Search

    Brian Scott Krongold; Douglas L. Jones

    2003-01-01

    The high peak-to-average power ratio (PAR) in orthogonal frequency division multiplexing (OFDM) modulation systems can significantly reduce power efficiency and performance. Methods exist which alter or introduce new signal constellations to combat large signal peaks. We present a new PAR-reduction method that dynamically extends outer constellation points in active (data-carrying) channels, within margin-preserving constraints, in order to minimize the peak

  11. Sixth Northwest Conservation and Electric Power Plan Chapter 4: Conservation Supply Assumptions

    E-print Network

    Sixth Northwest Conservation and Electric Power Plan Chapter 4: Conservation Supply Assumptions.............................................................................................. 4 Estimating the Cost of Conservation............................................................................................................... 13 Estimating the Availability of Conservation Over Time

  12. ORNL irradiation creep facility

    SciTech Connect

    Reiley, T.C.; Auble, R.L.; Beckers, R.M.; Bloom, E.E.; Duncan, M.G.; Saltmarsh, M.J.; Shannon, R.H.

    1980-09-01

    A machine was developed at ORNL to measure the rates of elongation observed under irradiation in stressed materials. The source of radiation is a beam of 60 MeV alpha particles from the Oak Ridge Isochronous Cyclotron (ORIC). This choice allows experiments to be performed which simulate the effects of fast neutrons. A brief review of irradiation creep and experimental constraints associated with each measurement technique is given. Factors are presented which lead to the experimental choices made for the Irradiation Creep Facility (ICF). The ICF consists of a helium-filled chamber which houses a high-precision mechanical testing device. The specimen to be tested must be thermally stabilized with respect to the temperature fluctuations imposed by the particle beam which passes through the specimen. Electrical resistance of the specimen is the temperature control parameter chosen. Very high precision in length measurement and temperature control are required to detect the small elongation rates relevant to irradiation creep in the test periods available (approx. 1 day). The apparatus components and features required for the above are presented in some detail, along with the experimental procedures. The damage processes associated with light ions are discussed and displacement rates are calculated. Recent irradiation creep results are given, demonstrating the suitability of the apparatus for high resolution experiments. Also discussed is the suitability of the ICF for making high precision thermal creep measurements.

  13. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells

    Microsoft Academic Search

    Sandra Iden; Daniela Rehder; Benjamin August; Atsushi Suzuki; Karen Wolburg-Buchholz; Hartwig Wolburg; Shigeo Ohno; Jürgen Behrens; Dietmar Vestweber; Klaus Ebnet

    2006-01-01

    A cell polarity complex consisting of partitioning defective 3 (PAR-3), atypical protein kinase C (aPKC) and PAR-6 has a central role in the development of cell polarity in epithelial cells. In vertebrate epithelial cells, this complex localizes to tight junctions. Here, we provide evidence for the existence of a distinct PAR protein complex in endothelial cells. Both PAR-3 and PAR-6

  14. Hearing Conservation Medical Program

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Background on hearing impairment is presented including causes and criteria for safe noise levels. The purpose of the Hearing Conservation Program at LeRC is outlined, and the specifics of the Medical Surveillance Program for Hearing Impairment at LeRC are discussed.

  15. Communities, Cameras, and Conservation

    ERIC Educational Resources Information Center

    Patterson, Barbara

    2012-01-01

    Communities, Cameras, and Conservation (CCC) is the most exciting and valuable program the author has seen in her 30 years of teaching field science courses. In this citizen science project, students and community volunteers collect data on mountain lions ("Puma concolor") at four natural areas and public parks along the Front Range of Colorado.…

  16. EVOLUTIONARY ECOLOGY Conservation Biology

    E-print Network

    Prestwich, Ken

    1 EVOLUTIONARY ECOLOGY 1 Conservation Biology Spring 2009 Evolutionary ecologists attempt of evolution on the different topics we have already discussed from a functional standpoint, namely, population competition in such an environment would favor those individuals who channel all their energy into producing

  17. Promoting household energy conservation

    Microsoft Academic Search

    Linda Steg

    2008-01-01

    It is commonly assumed that households must change their behaviour to reduce the problems caused by increasing levels of fossil energy use. Strategies for behaviour change will be more effective if they target the most important causes of the behaviour in question. Therefore, this paper first discusses the factors influencing household energy use. Three barriers to fossil fuel energy conservation

  18. Energy conservation standards

    Microsoft Academic Search

    F. S. Dubin; C. G. Jr. Long

    1982-01-01

    The purpose of this book is to present a framework for understanding energy flows in buildings. This book may be used to trace and measure energy flows in a building, to determine which conservation options are most suitable, and to choose materials, forms, systems, and design features. Other topics covered include the cross-influences of lighting, air conditioning and other internal

  19. Energy Conservation in GTR

    Microsoft Academic Search

    Carl Hoefer

    2000-01-01

    The topics of gravitational field energy and energy-momentum conservation in General Relativity theory have been unjustly neglected by philosophers. If the gravitational field in space free of ordinary matter, as represented by the metric gab itself, can be said to carry genuine energy and momentum, this is a powerful argument for adopting the substantivalist view of spacetime.This paper explores the

  20. Conservator Animal Facility

    E-print Network

    Orchids Conservator M. Jones Animal Facility Manager 1RS04 Research Faculty J. Creedon Research Dev. Research Compliance A.Rubenstein Radiation Safety Committee S. Sechrist Review Board G. Maihafer Applied Res. Center H. Elsayed-Ali Patents Committee M. Larrousi Dir. Research Development K. Eck Dir. Patents

  1. The Conservation Alternative 

    E-print Network

    Allaire, W. F.

    1979-01-01

    Of all of the issues involved in our national energy dilemma, the matter of conservation of energy has, without a doubt, received major attention. Much has been said on the subject and certainly a great deal has been written on the many facets...

  2. Marine Conservation Biology Institute

    NSDL National Science Digital Library

    Stay current with the latest marine conservation issues, plus find information on workshops and job and research opportunities. Access information on the latest research, legislation, and MCBI's latest publications. Learn about marine protected areas, destructive fishing practices, endangered species, and how MCBI is advancing marine science. Features include a photo gallery, links to an abundance of worldwide external resources, and several downloadable videos.

  3. The Getty Conservation Institute

    NSDL National Science Digital Library

    2008-01-01

    Started in 1985, The Getty Conservation Institute (GCI) "works internationally to advance conservation practice in the visual arts." Their mission is quite broad, as it includes conservation projects that involve architecture, individual objects, and site examinations. First-time visitors may wish to start by looking at the "What's New" area on the right-hand side of the homepage. Here they will find short videos on Asian orange colorants, information about Middle East heritage databases, and a direct link to the latest edition of the GCI's newsletter, "Conservation". Moving on, the "Free PDF Publications" area contains access to full-length books, reports, glossaries, and short papers published by the GCI. The "Videos and Audio" area contains a number of compelling talks, including a conversation with a panel of experts about long-term preservation plans for the bridges that span the Los Angeles River. Finally, the site also contains information for potential visiting scholars, graduate students, and interns within the "Public Programs" area of the site.

  4. Conservation in Conflict

    NSDL National Science Digital Library

    Wildlife Conservation Society

    What happens when war occurs in areas where there is war? Ecologist Peter Zahler who has worked in Afghanistan since 2002, talks about how conserving biodiversity may bring peace to the war-torn region. You can read more about Zahler's work in the article Nurturing Wildlife in War-Torn Afghanistan that appeared in the New Yorker Times in December, 2011.

  5. The vacuum conservation theorem

    E-print Network

    E. Minguzzi

    2015-02-28

    A version of the vacuum conservation theorem is proved which does not assume the existence of a time function nor demands stronger properties than the dominant energy condition. However, it is shown that a stronger stable version plays a role in the study of compact Cauchy horizons.

  6. Conservation Action Project (CAP)

    Microsoft Academic Search

    Peter Townsend

    1983-01-01

    The Peak National Park Study Centre, Losehill Hall has never been short of ideas. In its position close to, but just outside, the official educational system, it can attempt to objectively assess trends, formulate policies, and, in accordance with its own conservation objectives, make a positive contribution to curriculum development and innovation in environmental education. On Wednesday, 5th March 1980,

  7. Communication and Energy Conservation

    Microsoft Academic Search

    Jack M. McLeod; Carroll J. Glynn; Robert J. Griffin

    1987-01-01

    Surveys of homeowners in two Wisconsin communities examined the relationship of media use to a set of cognitive, attitudinal, and behavioral components of energy conservation. The perceived importance of the energy issue was associated with media use in both communities. In addition, this relationship was stronger the more energy related the communication variable. Communicaton did not, however, relate consistently to

  8. Kiwi Careers - Conservator

    NSDL National Science Digital Library

    Career Services KiwiCareers - Govt. of New Zeland

    Mark Stranage fixes photographs. He takes damaged photos and nurses them back to health. Read his profile to learn how he got this job and how he does his work. Check the other links at this site to find out what tasks a conservator generally performs, typical working conditions and pay.

  9. CPT conserving cosmological birefringence

    E-print Network

    C. Q. Geng; S. H. Ho; J. N. Ng

    2007-12-29

    We demonstrate that the cosmological birefringence can arise from CPT conserving effect, originated from the CPT-even dimension-six Chern-Simons-like term. We show that a sizable rotation polarization angle in the data of the cosmic microwave background radiation polarization can be induced.

  10. Water Conservation in Oman

    Microsoft Academic Search

    Hayder A. Abdel-Rahman; Isam Mohammed Abdel-Magid

    1993-01-01

    Limited resources and growing needs for water have triggered a nationwide campaign for water conservation in the Sultanate of Oman. A land and soil survey study of Oman shows the availability of more arable land than present water resources could support. Groundwater is the main source for agricultural production. Overpumping at rates higher than the natural recharge has resulted in

  11. Water conservation plan guidelines

    SciTech Connect

    NONE

    1998-08-06

    These Water Conservation Plan Guidelines are addressed to water system planners but use of the Guidelines is not required by federal law or regulation. The first part of the document introduces the Guidelines and provides information to the States about their nature and possible use. The second part of the document, written for water systems, is an overview to the organization, content, and the use of the Guidelines. The next three parts contain the water conservation plan Guidelines: Basic, Intermediate, and Advanced. The Basic Guidelines are designed for use by water systems serving populations of 10,000 or fewer; The Intermediate Guidelines are designed for water systems serving between 10,000 and 100,000 people; The Advanced Guidelines are designed for water systems serving more than 100,000 people. Six appendixes to the Guidelines provide supporting information: detailed descriptions of conservation measures (Appendix A), conservation benchmarks (Appendix B), acronyms and a glossary (Appendix C), information resources (Appendix D), funding sources (Appendix E), and state contacts (Appendix F).

  12. Foundry energy conservation workbook

    SciTech Connect

    Not Available

    1990-12-31

    This report discusses methods for promoting energy conservation in foundries. Use of electric power, natural gas, and coke are evaluated. Waste heat recovery systems are considered. Energy consumption in the specific processes of electric melting, natural gas melting, heat treatments, ladle melting, and coke fuel melting is described. An example energy analysis is included. (GHH)

  13. Foundry energy conservation workbook

    SciTech Connect

    none,

    1990-10-01

    This report discusses methods for promoting energy conservation in foundries. Use of electric power, natural gas, and coke are evaluated. Waste heat recovery systems are considered. Energy consumption in the specific processes of electric melting, natural gas melting, heat treatments, ladle melting, and coke fuel melting is described. An example energy analysis is included. (GHH)

  14. Marine Conservation Institute

    NSDL National Science Digital Library

    Stay current with the latest marine conservation issues, plus find information on workshops and job and research opportunities. Access information on the latest research, legislation, and MCI's latest publications. Learn about marine protected areas, destructive fishing practices, endangered species, and how MCI is advancing marine science. Features include a photo gallery, links to an abundance of worldwide external resources, and several downloadable videos.

  15. Conservation Directory, 1974.

    ERIC Educational Resources Information Center

    Clark, William E., Ed.

    The 1974 Conservation Directory is the 19th edition of a national comprehensive listing of organizations, agencies, and officials concerned with natural resources. It includes entries for about 1,400 organizations and over 7,000 individuals. Sections listing members of Congress, congressional committees, federal agencies, international, national,…

  16. Conservation Conflicts Across Africa

    Microsoft Academic Search

    Andrew Balmford; Joslin L. Moore; Thomas Brooks; Neil Burgess; Louis A. Hansen; Paul Williams; Carsten Rahbek

    2001-01-01

    There is increasing evidence that areas of outstanding conservation importance may coincide with dense human settlement or impact. We tested the generality of these findings using 1°-resolution data for sub-Saharan Africa. We find that human population density is positively correlated with species richness of birds, mammals, snakes, and amphibians. This association holds for widespread, narrowly endemic, and threatened species and

  17. Coastal Conservation Network (CCN)

    NSDL National Science Digital Library

    2012-01-01

    The Coastal Conservation Network, (CCN), is a non-profit organization founded by Garry Brown, summer 2011, with an objective to facilitate nonprofits to effectively communicate with the public, collaborate on programs and projects, and enhance the voice of the marine environmental community on a global scale through the use of new technology and the social media.

  18. December 18, 2008 Conservation

    E-print Network

    transfers energy to salt/water boiler; steam drives conventional steam turbine generator Molten salt thermal Council Northwest Power and Conservation Council Dish/Engine Heat-driven engine/generator (usually energy in an oil/water boiler; steam drives conventional steam turbine generator Oil thermal storage

  19. Creative Soil Conservation

    NSDL National Science Digital Library

    Martha Smith

    2010-02-01

    Take plant lessons outdoors with this engaging and inquiry-based activity in which third-grade students learn how to apply soil conservation methods to growing plants. They also collect data and draw conclusions about the effectiveness of their method of

  20. Many glitters of conservation

    Microsoft Academic Search

    Hall

    1980-01-01

    Some of the glitter and media-reported hoopla of energy conservation is discussed, and some facts to dull that glitter are described. On a natonal TV program in the US, the glitter of an electric car drive system and an airborne bicycle powered by solar photovoltaic cells was presented. But, analysis of the energy required to manufacture the electric batteries and

  1. Conservation and solar guidelines

    SciTech Connect

    Balcomb, J.D.

    1983-01-01

    Guidelines are given for selecting R-values and infiltration levels, and determining the size of the solar collection area for passive solar buildings. The guidelines are based on balancing the incremental cost/benefit of conservation and passive solar strategies. Tables are given for 90 cities in the US and the results are also displayed on maps. An example is included.

  2. Conservation Is Job One.

    ERIC Educational Resources Information Center

    Hatzai, Glen

    1998-01-01

    The University of Michigan, winner of a federal award for its campus energy conservation, has developed a building automation system that uses direct-digital-control technology to manage energy use. The project, undertaken in partnership with an energy management company, has saved over $10 million since its inception, and includes a revolving…

  3. Measuring biodiversity for conservation

    E-print Network

    Reynolds, John D.

    Measuring biodiversity for conservation Summary Policy document 10/03 May 2003 ISBN 0 85403 592 3 This report can be found at www.royalsoc.ac.uk #12;The reality of ongoing biodiversity loss The living world for assimilating data on the loss of biodiversity and for assessing its impact on society, does not exist. Losses

  4. Conservation of Library Materials.

    ERIC Educational Resources Information Center

    Illinois Libraries, 1985

    1985-01-01

    Twelve articles cover books as artifacts; workstations for conservation of library materials; care of scrapbooks, albums, and photographs; map preservation; library environment; flood recovery; disaster prevention and preparedness; incorporating preservation into library organization; and bibliography of Chester Public Library (Illinois) First…

  5. Course Syllabus Conservation Techniques

    E-print Network

    Chen, Kuang-Yu

    of communication between students throughout the class. Grading System This course utilizes student. 3. Final exam-The final exam comprises 15% of the overall grade. The exam is open notes, open in the application of conservation and management. This course is an introduction to the diverse ways information

  6. Energy conservation and sleep

    Microsoft Academic Search

    Ralph J. Berger; Nathan H. Phillips

    1995-01-01

    Phylogenetic and ontogenetic associations between sleep and endothermy are consistent with the hypothesis that sleep evolved in conjuction with endothermy to offset the high energetic cost of endothermy. The electrophysiological and thermoregulatory continuum of slow wave sleep, circadian torpor and hibernation substantiates a primordial link between sleep and energy conservation. Sleep constitutes a circadian and circannual rhythm of hypometabolic adaptation

  7. The vacuum conservation theorem

    NASA Astrophysics Data System (ADS)

    Minguzzi, E.

    2015-03-01

    A version of the vacuum conservation theorem is proved which does not assume the existence of a time function nor demands stronger properties than the dominant energy condition. However, it is shown that a stronger stable version plays a role in the study of compact Cauchy horizons.

  8. Campus energy conservation study

    Microsoft Academic Search

    J. S. Blossom; D. R. Bahnfleth

    1979-01-01

    Recommendations were made for improving a midwestern military academy's central heating plant as part of a program for conserving energy on campus and developing a multi-fuel capability after an energy management evaluation was made. The evaluating team's findings are summarized and corrective measures for immediate changes with little capital investment are listed. A solar hot water system would only be

  9. CONSERVATION NOTES WILD CHICKENS

    E-print Network

    ^-^ CONSERVATION NOTES AMERICA'S WILD CHICKENS Most natural environments in the United States once had at least one kind of Nature's wild chickens, the upland game birds. Just as there are many kinds, wild turkey, and chachalaca. Like domestic chickens they are ground dwellers. They scratch chickenlike

  10. Conservation of Matter Lab

    NSDL National Science Digital Library

    The phenomena are three examples that illustrate conservation of matter - dissolving salt in water, adding an effervescent tablet to water, and a change in state from ice to water. The resource describes a laboratory exercise that asks students to compare the mass before substances are combined or changed to the mass after substances are combined or changed.

  11. Invasive Species Conservation Biology

    E-print Network

    Gottgens, Hans

    Invasive Species Conservation Biology Dr. Philpott Thanks to Dr. Mayer for many images and text #12 · Bluegrass in Kentucky · Zebra mussels in Lake Erie #12;Invasive Species · Terminology · Routes of Invasion species · What is the difference between exotic, non-indigenous, non-native, alien, nuisance, and invasive

  12. A mathematical model of ParA filament-mediated chromosome movement in Caulobacter crescentus.

    PubMed

    Shtylla, Blerta; Keener, James P

    2012-08-21

    Caulobacter crescentus uses the dynamic interactions between ParA and ParB proteins to segregate copies of its circular chromosome. In this paper, we develop two mathematical models of the movement of the circular chromosome of this bacterium during division. In the first model, posed as a set of stochastic differential equations (SDE), we propose that a simple biased diffusion mechanism for ParB/ParA interactions can reproduce the observed patterns of ParB and ParA localization in the cell. The second model, posed as a set of nonlinear partial differential equations, is a continuous treatment of the problem where we use results from the SDE model to describe ParB/ParA interactions and we also track ParA monomer dynamics in the cytoplasm. For both models, we show that if ParB complexes bind weakly and nonspecifically to ParA filaments, then they can closely track and move with the edge of a shrinking ParA filament bundle. Unidirectional chromosome movement occurs when ParB complexes have a passive role in depolymerizing ParA filaments. Finally, we show that tight control of ParA filament dynamics is essential for proper segregation. PMID:22588023

  13. Supplementary Table 2 Conservation of helicase motifs. Conservation

    E-print Network

    Kowalczykowski, Stephen C.

    . The truncation is a conserved feature of SWI2/SNF2 proteins (Snf2 hmm of PlSTl), and the Rad54 structure/SNF2 family (Snf2 hmm TSYEl), and is part of the previously defined Snf-A motif. II Conserved in SF1 two residues that are highly conserved in the Snf2 hmm (DEgHrLKN; higher conservation in uppercase

  14. The retinal irradiance and spectral properties of the multiport illumination system for vitreous surgery.

    PubMed

    Koch, F H; Schmidt, H P; Mönks, T; Blumenröder, S H; Haller, A; Steinmetz, R L

    1993-10-15

    The multiport illumination system was developed as a fiberoptically illuminated pars plana cannula system for vitreous surgery. The retinal irradiance of the multiport illumination system and several other commonly used endoilluminators (light pipes) measured at 5 mm are comparable, ranging from 94 to 256 mW/cm2. In the actual surgical setting, however, the retinal irradiance of the multiport illumination system is far less (56 mW/cm2) because the end of the fiberoptic cables are fixated in the pars plana 16.5 mm away from the retinal surface. A reduction in the maximal intensity (100%) to 50% reduces the retinal irradiance by approximately two thirds to 3.7 mW/cm2. The light emitted by the multiport illumination system used in conjunction with a long-wave pass filter with a cutoff wavelength of 420 nm reduces the amount of short-wavelength light by one third to about 4% of the overall irradiance. PMID:8213981

  15. Quelques exercises 1. Soit la surface delimitee en dessous par l'axe des x au-dessus par la courbe

    E-print Network

    Katalin, Nagy

    Quelques exercises 1. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la surface autour de l'axe des x. 2. Soit la surface d´elimit´ee en dessous par l'axe des x au-dessus par la cette surface autour de l'axe des x. 3. Tracer la graphe de la courbe y = 1 - x et prendre l'arc fini

  16. MESURE DU NOMBRE MOYEN DE NEUTRONS MIS PAR FISSION INDUITE DANS 238U PAR DES NEUTRONS DE 14,2 MeV

    E-print Network

    Boyer, Edmond

    66. MESURE DU NOMBRE MOYEN DE NEUTRONS ÉMIS PAR FISSION INDUITE DANS 238U PAR DES NEUTRONS DE 14 avons mesuré le rapport 03BD/03BD', du nombre moyen de neutrons 03BD émis par fission de 238U avec des neutrons de 14,2 MeV, au nombre de neutrons v' émis par fission de 235U avec des neutrons thermiques

  17. Energy Conservation in the School Curriculum. Energy Conservation Guidelines 3.

    ERIC Educational Resources Information Center

    Peterson, Irving M., Ed.

    Third in a series of four publications on energy conservation, this booklet discusses the role of an energy conservation curriculum. The pamphlet outlines developing a curriculum, making goal statements, instilling an energy ethic in the minds of students, and effecting an interdisciplinary approach to energy conservation instruction. The…

  18. Conservation businesses and conservation planning in a biological diversity hotspot.

    PubMed

    Di Minin, Enrico; Macmillan, Douglas Craig; Goodman, Peter Styan; Escott, Boyd; Slotow, Rob; Moilanen, Atte

    2013-08-01

    The allocation of land to biological diversity conservation competes with other land uses and the needs of society for development, food, and extraction of natural resources. Trade-offs between biological diversity conservation and alternative land uses are unavoidable, given the realities of limited conservation resources and the competing demands of society. We developed a conservation-planning assessment for the South African province of KwaZulu-Natal, which forms the central component of the Maputaland-Pondoland-Albany biological diversity hotspot. Our objective was to enhance biological diversity protection while promoting sustainable development and providing spatial guidance in the resolution of potential policy conflicts over priority areas for conservation at risk of transformation. The conservation-planning assessment combined spatial-distribution models for 646 conservation features, spatial economic-return models for 28 alternative land uses, and spatial maps for 4 threats. Nature-based tourism businesses were competitive with other land uses and could provide revenues of >US$60 million/year to local stakeholders and simultaneously help meeting conservation goals for almost half the conservation features in the planning region. Accounting for opportunity costs substantially decreased conflicts between biological diversity, agricultural use, commercial forestry, and mining. Accounting for economic benefits arising from conservation and reducing potential policy conflicts with alternative plans for development can provide opportunities for successful strategies that combine conservation and sustainable development and facilitate conservation action. PMID:23565917

  19. Evaluation de l'exposition humaine au plomb par ingestion et inhalation de PM10 et PM2,5 mises par une usine de recyclage de batteries

    E-print Network

    Paris-Sud XI, Université de

    Evaluation de l'exposition humaine au plomb par ingestion et inhalation de PM10 et PM2,5 émises par plomb et autres métaux par deux voies d'exposition : l'inhalation et l'ingestion. Dans le but de : elles représentent non seulement la fraction inhalable mais contribuent probablement à une fraction non

  20. Diffusion par le deutrium des neutrons de 14,1 MeV dans une direction inclrne de 30 par rapport

    E-print Network

    Boyer, Edmond

    803 FIG. 5. - Diffusion par le deutérium des neutrons de 14,1 MeV dans une direction inclrnée de 30° par rapport à celle des neutrons incidents. quement utilise une méthode de temps de vol entre les neutrons dans le compteur à scintil- lation équipé d'un plastique. Les impulsions déli- vrées par ce

  1. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    PubMed Central

    Ebersbach, Gitte; Gerdes, Kenn

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All par-encoded ATPases belong to one of two protein superfamilies, Walker-type and actin-like ATPases. This property was recently used to divide par loci into Types I and II loci. We show here that the Escherichia coli virulence factor pB171 encodes a double par locus that consists of one Type I and one Type II locus. Separately, each locus stabilized a test-plasmid efficiently. Together, the two loci mediated even more efficient plasmid stabilization. The par loci have a unique genetic organization in that they share a common central region at which the two different DNA-binding proteins probably act. Interestingly, a fusion protein consisting of the Walker-type ParA ATPase and Gfp was functional and oscillated in nucleoid regions on a time scale of minutes. ParA-green fluorescent protein (Gfp) oscillation depended on both ParB and parC but was independent of minCDE. Point mutations in the Walker A box motif simultaneously abolished plasmid stabilization and ParA-Gfp oscillation. These observations raise the possibility that ParA oscillation is prerequisite for active plasmid segregation. PMID:11752455

  2. Irradiation Stability of Carbon Nanotubes 

    E-print Network

    Aitkaliyeva, Assel

    2010-01-14

    Ion irradiation of carbon nanotubes is a tool that can be used to achieve modification of the structure. Irradiation stability of carbon nanotubes was studied by ion and electron bombardment of the samples. Different ion ...

  3. Sagebrush Ecosystem Conservation and Management

    E-print Network

    Aldridge, Cameron

    Sagebrush Ecosystem Conservation and Management: Ecoregional Assessment Tools and Models SagebrushEcosystemConservationandManagement Hanser Leu Knick Aldridge Sagebrush Ecosystem Conservation of the remaining strongholds of the sagebrush ecosystem. However, like most sagebrush habitats, threats

  4. 76 FR 22785 - Wetland Conservation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ...NRCS-2011-0010] RIN 0578-AA58 Wetland Conservation AGENCY: Office of the Secretary...Paperwork Reduction Act. Background Existing wetland conservation provisions in 7 CFR part 12 require that NRCS' certification of a wetland determination be completed according...

  5. Intrinsic Value Can Help Conservation

    E-print Network

    Fuentes, Marcelino

    of humankind's anthropocentrism, no basis for conservation is likely to trump immediate human needs that "humankind's anthropocentrism" means that no basis for conservation is likely to be effective. It is also

  6. Biodiversity Conservation in Tropical Agroecosystems

    E-print Network

    Biodiversity Conservation in Tropical Agroecosystems A New Conservation Paradigm Ivette Perfectoa. This conclusion has major consequences for biodiversity con- servation in fragmented tropical forests the literature on biodiversity in tropical agricul- tural landscapes and present evidence that many tropical

  7. Cooling Tower Energy Conservation Optimization 

    E-print Network

    Burger, R.

    1985-01-01

    COOLING TOWER ENERGY CONSERVATION OPTIMIZATION Robert Burger Burger Associates, Inc. Dallas, Texas Energy conservation strategies involve more than examination of fan horsepower. Colder water and pumping head provide vast savings potentials...

  8. Cooling Towers, Energy Conservation Machines 

    E-print Network

    Burger, R.

    1980-01-01

    ------------~'l:~' COOLING TOWERS, ENERGY CONSERVATION MACHINES 1980 CONFERENCE ON INDUSTRIAL ENERGY CONSERVATION TECHNOLOGY Robert Burger B~rger Associates Dallas, Texas ABSTRACT Cooling towers, in all too many industrial plants, are often...

  9. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    SciTech Connect

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned.

  10. Generic phytosanitary irradiation treatments

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The history of the development of generic phytosanitary irradiation (PI) treatments is discussed beginning with its initial proposal in 1986. Generic PI treatments in use today are 150 Gy for all hosts of Tephritidae, 250 Gy for all arthropods on mango and papaya shipped from Australia to New Zeala...

  11. Update on meat irradiation

    SciTech Connect

    Olson, D.G. [Iowa State Univ., Ames, IA (United States)

    1997-12-01

    The irradiation of meat and poultry in the United States is intended to eliminate pathogenic bacteria from raw product, preferably after packaging to prevent recontamination. Irradiation will also increase the shelf life of raw meat and poultry products approximately two to three times the normal shelf life. Current clearances in the United States are for poultry (fresh or frozen) at doses from 1.5 to 3.0 kGy and for fresh pork at doses from 0.3 to 1.0 kGy. A petition for the clearance of all red meat was submitted to the Food and Drug Administration (FDA) in July 1994. The petition is for clearances of fresh meat at doses from 1.5 to 4.5 kGy and for frozen meat at {approximately}2.5 to 7.5 kGy. Clearance for red meat is expected before the end of 1997. There are 28 countries that have food irradiation clearances, of which 18 countries have clearances for meat or poultry. However, there are no uniform categories or approved doses for meat and poultry among the countries that could hamper international trade of irradiated meat and poultry.

  12. Uniform high irradiance source

    NASA Technical Reports Server (NTRS)

    Lunde, A. R.; Fortini, A.; Buchele, D. R.

    1975-01-01

    New 50 Kw xenon short arc lamp mounted within elliptical collector provides irradiance levels up to 4.4 x 10 to the 7th power watts/sq m with non-uniformity ratio of 3.30. Energy mixer or light pipe between lamp source and target improves non-uniformity to required ratio.

  13. Phytosanitary applications of irradiation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Phytosanitary treatments are used to disinfest agricultural commodities of quarantine pests so the commodities can be shipped across quarantine barriers to trade. Ionizing irradiation is a promising treatment that is increasing in use. Almost 19,000 tons of sweet potatoes and several fruits, plus ...

  14. Combination processes in food irradiation

    Microsoft Academic Search

    B. R. Thakur; R. K. Singh

    1995-01-01

    Irradiation is emerging as a potential method of food preservation. It is being used to extend the shelf life of raw and processed foods in many countries worldwide. Like all other methods of food preservation, irradiation has a number of limitations. Irradiation, when used alone, can cause the development of undesirable sensory and chemical changes in some foods, depending on

  15. Advanced energy conservation technology program

    Microsoft Academic Search

    Grey

    1976-01-01

    Effective energy conservation is an essential element in national policy. This Conference was assembled to consider the processes by which advanced energy conservation engineering knowledge and methods are introduced into practical end-product manufacture and use, and to examine the possibilities for accelerating these processes. The specific Conference goals were (a) to identify those energy conservation technical disciplines which offer the

  16. Conservation of tropical plant species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This book is designed to provide a review of the methods and current status of conservation of many tropical plant species. Future perspectives of conservation of tropical species will also be discussed. The section on methods covers the range of conservation techniques, in situ, seed banking, in vi...

  17. Majoring in Forest Resources & Conservation

    E-print Network

    Watson, Craig A.

    Majoring in Forest Resources & Conservation University of Florida/IFAS School of Forest Resources & Conservation www.sfrc.ufl.edu ~ 352-846-0847 ~ khaselier@ufl.edu Protected Areas Management is for students interested in managing lands for conservation and restoration purposes, usually on lands owned

  18. Genetic conservation of native trees

    E-print Network

    Genetic conservation of native trees Scott McG. Wilson1 and C. J. A. Samuel Over recent years, the genetic conservation of British native tree populations has become an increasingly important part policy-makers in the genetic basis of forest biodiversity conservation, both at the UK and, more

  19. LABORATORY IV CONSERVATION OF ENERGY

    E-print Network

    Minnesota, University of

    Lab IV - 1 LABORATORY IV CONSERVATION OF ENERGY In this lab you will begin to use the principle of conservation of energy to determine the motion resulting from interactions that are difficult to analyze using force concepts alone. You will explore how conservation of energy is applied to real interactions. Keep

  20. Discovering Conservation Rules Lukasz Golab #

    E-print Network

    Greenberg, Albert

    Discovering Conservation Rules Lukasz Golab # , Howard Karloff , Flip Korn , Barna Saha , Divesh a "conservation law" between related quantities. For example, in traffic monitoring, every incoming event outgoing counterpart. We propose a new class of constraints--Conservation Rules--that express the semantics

  1. Conservation Comparison of Plan, Current

    E-print Network

    Northwest Power and Conservation Council Comparison of Plan, Current Policy, and No-Policy Cases Power Committee Web Meeting June 30, 2009 Northwest Power and Conservation Council Definition of Cases, new plant emissions limits, and carbon price risk #12;Northwest Power and Conservation Council

  2. Energy Management and Conservation Plan

    E-print Network

    Energy Management and Conservation Plan December 2005 #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan Page 2 of 24 Table of Contents Section One: Executive: Reporting Progress #12;Texas Transportation Institute December 2005 Energy Management and Conservation Plan

  3. Total Conservation: Ethos or Pathos.

    ERIC Educational Resources Information Center

    Keith, William J. B.

    1987-01-01

    The United States and Canada are the world's top energy consumers. New approaches to establish a conservation ethic include (1) applying wartime strategies to energy conservation, (2) telling public figures of the importance of conservation, (3) lobbying governments, and (4) using the common sense of our forebearers. (MLF)

  4. Conservation systems in the Southeast

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This presentation describes how conservation systems that include non-inversion tillage and cover crops, a key component of conservation systems, are managed in the Southeast to maximize benefits. Benefits include weed suppression, moisture conservation, and increased organic matter contents. Mana...

  5. Estimating Conservation Thresholds on Rangelands

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Conservation Effects Assessment Project (CEAP) is a multi-agency effort designed to quantify the environmental and economic impacts of land conservation practices. One of USDA’s goals is to identify Conservation Thresholds, the point at which accelerated erosion occurs, and to examine the usefu...

  6. Saving Money Through Energy Conservation.

    ERIC Educational Resources Information Center

    Presley, Michael H.; And Others

    This publication is an introduction to personal energy conservation. The first chapter presents a rationale for conserving energy and points out that private citizens control about one third of this country's energy consumption. Chapters two and three show how to save money by saving energy. Chapter two discusses energy conservation methods in the…

  7. Approved Practices in Soil Conservation.

    ERIC Educational Resources Information Center

    Foster, Albert B.

    This book is written for individuals who wish to apply conservation practices, especially those of soil and water conservation, without technical assistance, to meet one's own conditions, and within his own capability to apply them. To meet these needs, the book includes a discussion and description of soil and water conservation methods for the…

  8. Water Savings Through Conservation Tillage

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Through a partnership with the University of Georgia – College of Agriculture and Environmental Sciences, USDA-Agricultural Research Service, USDA-Natural Resource Conservation Service, Soil and Water Conservation Society and Resource Conservation and Development Councils to name a few, research and...

  9. La dpense minima serait, dans des conditions moyennes, de ofr,002 par heure et par candie, soit environ of1',032 par heure

    E-print Network

    Boyer, Edmond

    dans le verre et dans le spath d'Islande avec la température); Wied. Ann., t. XXV, p. 87;I885. Dans le verre et le spath d'Islande, les indices croissent en même temps que la température. Les mesures celui que Fresnel a imaginé pour le quartz. Une longue auge de verre (0m,54 de long) fu t partagée par

  10. Herpetological Conservation & Biology

    NSDL National Science Digital Library

    2012-09-21

    In 2006, the Herpetological Conservation & Biology journal was started to offer a place for manuscripts in the field "that were descriptive or natural history oriented." This journal publishes original peer-reviewed research, reviews, and perspectives on the "ecology, natural history, management, and conservation biology of amphibians and reptiles." Recent articles have included "Population decline in Grassland Earless Lizards" and "Invasive shrub benefits a Sri Lankan lizard." Visitors can click on the Volumes tab to look over all of the past issues and search the entire archive here as well. The Photo Gallery is a real treat, featuring dozens of photos submitted by the editors and other users. Finally, visitors can also learn about how to submit material for possible publication, along with signing up for email updates.

  11. Northeast Document Conservation Center

    NSDL National Science Digital Library

    Founded in 1973, the Northeast Document Conservation Center (NDCC) was created to address the rapid deterioration of older paper-based documents in a number of institutions across New England. On their website, visitors can learn about their conservation and imaging services, and also examine some of their fine resources intended for members of the preservation community. The "Resources" area is a good place to start, as it contains a number of suggestions for preserving private and family collections and also contains a set of additional web-based resources and links. Beyond those materials, there are a number of digitized leaflets here, such as "Assessing Preservation Needs: A Self-Survey Guide" and "Preservation of Library and Archival Materials". The site is rounded out by an excellent disaster assistance section that includes an online disaster planning tool called "dPlan" and a set of general guidelines for archival institutions that may be coping with such situations.

  12. Environmental Conservation Online System

    NSDL National Science Digital Library

    The Environmental Conservation Online System (ECOS) is a gateway web site that provides access to data systems in the Endangered Species and Fisheries and Habitat Conservation program areas, as well as other FWS and Government data sources. ECOS provides a central point of access to assist FWS personnel in managing data and information as well as provide general public access to information from numerous FWS databases. ECOS allows users to view, query, and, in some cases, edit data. Some of the larger applications are: Threatened and Endangered Species System (TESS), Habitat Tracking Information System (HabITS), Fish Passage Decision Support System (FPDSS), Contaminant Assessment Program (CAP), and Environmental Contaminants Data Management System (ECDMS). Mapping capabilities are also available, utilizing spatially referenced data in these databases. The general mapping utility, Geotract, is an interactive tool that includes data relevant to many service personnel and the public. Other specialized mapping tools are available for specific project and end-user needs.

  13. Conservative entropic forces

    NASA Astrophysics Data System (ADS)

    Visser, Matt

    2011-10-01

    Entropic forces have recently attracted considerable attention as ways to reformulate, retrodict, and perhaps even "explain" classical Newtonian gravity from a rather specific thermodynamic perspective. In this article I point out that if one wishes to reformulate classical Newtonian gravity in terms of an entropic force, then the fact that Newtonian gravity is described by a conservative force places significant constraints on the form of the entropy and temperature functions. (These constraints also apply to entropic reinterpretations of electromagnetism, and indeed to any conservative force derivable from a potential.) The constraints I will establish are sufficient to present real and significant problems for any reasonable variant of Verlinde's entropic gravity proposal, though for technical reasons the constraints established herein do not directly impact on either Jacobson'sor Padmanabhan's versions of entropic gravity. In an attempt to resolve these issues, I will extend the usual notion of entropic force to multiple heat baths with multiple "temperatures" and multiple "entropies".

  14. Laser conservation paleontology

    NASA Astrophysics Data System (ADS)

    Asmus, John F.

    2001-10-01

    Just as lasers have found countless applications in science, industry, medicine, and entertainment, an array of real and potential uses for lasers in art-conservation analytes and practice have been investigated over the past thirty years. These include holographic recording, holographic recording, holographic nondestructive testing, laser-induced ultrasonic imaging, laser-scattering surface characterization, atomic and molecular analyses, photoacoustic spectroscopy, surface modification, as well as surface divestment and cleaning. The initial endeavors in exploring and assessing the utility of these tools for art conservation are recounted for investigations involving ruby, glass, ion, YAG, carbon dioxide, dye, and excimer lasers as well as high-intensity nonlaser light generators such as xenon flashlamps and argon pinchlamps. Initially, laser divestment/cleaning was, by general consensus, the least plausible laser application in art conservation. In the past ten years it has emerged to dominate all the other applications noted above. Today, at least a dozen firms supply user-friendly laser systems optimized for a range of art-conservation divestment applications. The first-generation laser-cleaning tools are essentially a laser, a beam-delivery device, and a debris- collection accessory. Advanced developmental work has turned in large measure to ancillary subsystems for more sophisticated process control. Of particular importance are acoustic, optical, spectral, EMP, and electronic-vision process control. Beam direction may be via manual, translational-scanner, or robotic beam positioning implemented by means of fiber optics, minors, or prisms and computer control. Substrate thermal alteration and debris redeposition may be minimized or avoided through the incorporation of a gas jet, fluid or fluid jet, or dry-ice blast.

  15. Jobs in Conservation Biology

    NSDL National Science Digital Library

    1999-01-01

    This searchable jobs listing, provided by the Society for Conservation Biology, is the place to start searching for positions at all levels from activitsts to field and laboratory assistants to professors. An excellent feature of this site is the collection of links to related jobs listing services including: The Chronicle of Higher Education,Science magazine, Environmental Careers World, Environmental Career Opportunities, Federal Job Opportunities Board (2), and several other agency jobs listings.

  16. Natural hybridization and conservation

    Microsoft Academic Search

    Meritxell Genovart

    2009-01-01

    This review deals with natural hybridization, an important subject in conservation biology. Natural hybridization is defined\\u000a as the secondary contact between two populations that have evolved separately over a long period of time. This process is\\u000a uncommon in terms of the total number of individuals involved, but is much less unusual if we consider the number of species\\u000a that hybridize.

  17. Wildlife Conservation Research Unit

    NSDL National Science Digital Library

    Oxford University has a very important website dedicated to its Wildlife Conservation Research Unit (WildCRU), that hopes to solve the "conflict between peoples' futures and wildlife conservation." There are several themes on the website, all of which can be found on the left hand menu. Visitors will find the following topics to explore: "Endangered Species", "Invasives", "Land Use & Biodiversity", "Fundamental Biology", "Wildlife Diseases", and "Wildlife as a Resource". The "Publications" link at the top right side of the page contains "Books", "Papers", "Reports", and "Theses" available to read online or find in a physical library. A multitude of animal issues are discussed in the documents here, including a paper called "The World Can't Have Wild Tigers and Eat Them, Too" and "State of Britain's Mammals 2008". The "Research" link near the top of the page, includes the dozens of research projects WildCRU is involved in, such as "Badger Genetic Research", "Transfrontier Conservation of Andean Cats" and "Towards Reducing the Total Environmental Impacts of Agriculture."

  18. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    SciTech Connect

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned.

  19. Image algebra preprocessor for the MasPar parallel computer

    NASA Astrophysics Data System (ADS)

    Meyer, Trevor E.; Davidson, Jennifer L.

    1991-07-01

    The development of a preprocessor for image algebra on the MasPar computer, a SIMD processor array, is discussed. One of the parallel languages used on the MasPar is MPL, a parallel version of the programming language C. This machine and language were chosen because of the close correspondence between MPL and image algebra and, as a result, MPL is easily extended to include image algebra. The preprocessor consists of three primary components: the lexical analyzer, the parser, and the code generator. The lexical analyzer converts the input stream into tokens the parser recognizes. The parser checks the program for syntax errors.The code generator produces MPL source code which is then compiled and run on the MasPar. The architecture of the MasPar computer is reviewed, and in particular the structures used for routing data through the array are examined. The parallel language MPL is also reviewed, with attention given to the methods in which the extensions to C in MPL interact with the MasPar architecture. The close correspondence between MPL and image algebra is specifically discussed. The authors present the structure and development of the image algebra preprocessor, including possible future extensions. Examples of image algebra preprocessor code and the corresponding MPL code produced by the preprocessor are given.

  20. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    SciTech Connect

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned.

  1. Expression and function of the leucine zipper protein Par-4 in apoptosis.

    PubMed Central

    Sells, S F; Han, S S; Muthukkumar, S; Maddiwar, N; Johnstone, R; Boghaert, E; Gillis, D; Liu, G; Nair, P; Monnig, S; Collini, P; Mattson, M P; Sukhatme, V P; Zimmer, S G; Wood, D P; McRoberts, J W; Shi, Y; Rangnekar, V M

    1997-01-01

    The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carboxy terminus. We have recently shown that the Par-4 protein binds, via its leucine zipper domain, to the zinc finger domain of Wilms' tumor protein WT1 (R. W. Johnstone et al., Mol. Cell. Biol. 16:6945-6956, 1996). In experiments aimed at determining the functional role of par-4 in apoptosis, an antisense par-4 oligomer abrogated par-4 expression and activator-driven apoptosis in rat prostate cancer cell line AT-3, suggesting that par-4 is required for apoptosis in these cells. Consistent with a functional role for par-4 in apoptosis, ectopic overexpression of par-4 in prostate cancer cell line PC-3 and melanoma cell line A375-C6 conferred supersensitivity to apoptotic stimuli. Transfection studies with deletion mutants of Par-4 revealed that full-length Par-4, but not mutants that lacked the leucine zipper domain of Par-4, conferred enhanced sensitivity to apoptotic stimuli. Most importantly, ectopic coexpression of the leucine zipper domain of Par-4 inhibited the ability of Par-4 to enhance apoptosis. Finally, ectopic expression of WT1 attenuated apoptosis, and coexpression of Par-4 but not a leucine zipperless mutant of Par-4 rescued the cells from the antiapoptotic effect of WT1. These findings suggest that the leucine zipper domain is required for the Par-4 protein to function in apoptosis. PMID:9199316

  2. Nanoparticle production by UV irradiation of combustion generated soot particles

    SciTech Connect

    Stipe, Christopher B.; Choi, Jong Hyun; Lucas, Donald; Koshland, Catherine P.; Sawyer, Robert F.

    2004-07-01

    Laser ablation of surfaces normally produce high temperature plasmas that are difficult to control. By irradiating small particles in the gas phase, we can better control the size and concentration of the resulting particles when different materials are photofragmented. Here, we irradiate soot with 193 nm light from an ArF excimer laser. Irradiating the original agglomerated particles at fluences ranging from 0.07 to 0.26 J/cm{sup 2} with repetition rates of 20 and 100 Hz produces a large number of small, unagglomerated particles, and a smaller number of spherical agglomerated particles. Mean particle diameters from 20 to 50 nm are produced from soot originally having a mean electric mobility diameter of 265nm. We use a non-dimensional parameter, called the photon/atom ratio (PAR), to aid in understanding the photofragmentation process. This parameter is the ratio of the number of photons striking the soot particles to the number of the carbon atoms contained in the soot particles, and is a better metric than the laser fluence for analyzing laser-particle interactions. These results suggest that UV photofragmentation can be effective in controlling particle size and morphology, and can be a useful diagnostic for studying elements of the laser ablation process.

  3. Animal Behavior Society Conservation Committee The Conservation Behaviorist, an electronic newsupdate, informs ABS

    E-print Network

    Grether, Gregory

    Animal Behavior Society Conservation Committee The Conservation, research trends in behavior and conservation, and relevant scientific news in conservation research where behavior plays an important role. www.animalbehavior.org/Committees/Conservation The ABS

  4. Energy conservation program guide for commercial buildings

    Microsoft Academic Search

    de Latour

    1975-01-01

    The following topics are discussed: the definition of the commercial building category, the purpose of the conservation program guide, energy conservation in existing buildings, energy conservation in new buildings, goals of the state energy conservation programs, and reports. (MHR)

  5. EVALUATING CONSERVATION EFFECTIVENESS AND ADAPTATION IN

    E-print Network

    Rissman, Adena

    EVALUATING CONSERVATION EFFECTIVENESS AND ADAPTATION IN DYNAMIC LANDSCAPES ADENA R. RISSMAN* I INTRODUCTION Despite the widespread use of conservation easements, their conservation outcomes are relatively unknown.1 Evaluating conservation easement effectiveness requires interdisciplinary research that reaches

  6. Soil and Water Conservation Spring 2014

    E-print Network

    Ma, Lena

    SWS 4233 Soil and Water Conservation Spring 2014 Instructor Susan Curry scurry@ufl.edu 352 equations and reduction practices, government conservation programs; water conservation, irrigation students with an understanding of the interconnectedness of soil and water conservation. The course

  7. Kootenai River Native Fish Conservation Aquaculture Master

    E-print Network

    Kootenai River Native Fish Conservation Aquaculture Master Plan Prepared by Kootenai Tribe of Idaho and experimental aquaculture program · 1989: Experimental aquaculture facility construction begins · 1990: First ­ conservation aquaculture listed as a priority action 1988 1996 Conservation aquaculture #12;Conservation

  8. Trends in Ocean Irradiance using a Radiative Model Forced with Terra Aerosols and Clouds

    NASA Technical Reports Server (NTRS)

    Gregg, Watson; Casey, Nancy; Romanou, Anastasia

    2010-01-01

    Aerosol and cloud information from MODIS on Terra provide enhanced capability to understand surface irradiance over the oceans and its variability. These relationships can be important for ocean biology and carbon cycles. An established radiative transfer model, the Ocean-Atmosphere Spectral Irradiance Model (OASIM) is used to describe ocean irradiance variability on seasonal to decadal time scales. The model is forced with information on aerosols and clouds from the MODIS sensor on Terra and Aqua. A 7-year record (2000-2006) showed no trends in global ocean surface irradiance or photosynthetic available irradiance (PAR). There were significant (P<0.05) negative trends in the Mediterranean Sea, tropical Pacific) and tropical Indian Oceans, of -7.0, -5.0 and -2.7 W/sq m respectively. Global interannual variability was also modest. Regional interannual variability was quite large in some ocean basins, where monthly excursions from climatology were often >20 W/sq m. The trends using MODIS data contrast with results from OASIM using liquid water path estimates from the International Satellite Cloud Climatology Project (ISCCP). Here, a global trend of -2 W/sq m was observed, largely dues to a large negative trend in the Antarctic -12 W/sq m. These results suggest the importance of the choice of liquid water path data sets in assessments of medium-length trends in ocean surface irradiance. The choices also impact the evaluation of changes in ocean biogeochemistry.

  9. Nanoparticules d'or: De l'imagerie par resonance magnetique a la radiosensibilisation

    NASA Astrophysics Data System (ADS)

    Hebert, Etienne M.

    Cette thèse approfondit l'étude de nanoparticules d'or de 5 nm de diamètre recouvertes de diamideéthanethioldiethylènetriaminepentacétate de gadolinium (DTDTPA:Gd), un agent de contraste pour l'imagerie par résonance magnétique (IRM). En guise de ciblage passif, la taille des nanoparticules a été contrôlée afin d'utiliser le réseau de néovaisseaux poreux et perméable des tumeurs. De plus les tumeurs ont un drainage lymphatique déficient qui permet aux nanoparticules de demeurer plus longtemps dans le milieu interstitiel de la tumeur. Les expériences ont été effectuées sur des souris Balb/c femelles portant des tumeurs MC7-L1. La concentration de nanoparticules a pu être mesurée à l'IRM in vivo. La concentration maximale se retrouvait à la fin de l'infusion de 10 min. La concentration s'élevait à 0.3 mM dans la tumeur et de 0.12 mM dans le muscle environnant. Les nanoparticules étaient éliminées avec une demi-vie de 22 min pour les tumeurs et de 20 min pour le muscle environnant. Les nanoparticules ont été fonctionnalisées avec le peptide Tat afin de leur conférer des propriétés de ciblage actif La rétention de ces nanoparticules a ainsi été augmentée de 1600 %, passant d'une demi-vie d'élimination de 22 min à 350 min. La survie des souris a été mesurée à l'aide de courbes Kaplan-Meier et d'un modèle mathématique évalue l'efficacité de traitements. Le modèle nous permet, à l'aide de la vitesse de croissance des tumeurs et de l'efficacité des traitements, de calculer la courbe de survie des spécimens. Un effet antagoniste a été observé au lieu de l'effet synergétique attendu entre une infusion de Au@DTDTPA:Gd et l'irradiation aux rayons X. L'absence d'effet synergétique a été attribuée à l'épaisseur du recouvrement de DTDTPA:Gd qui fait écran aux électrons produits par l'or. De plus, le moyen d'ancrage du recouvrement utilise des thiols qui peuvent s'avérer être des capteurs de radicaux. De plus, contrairement a ce qui était escompté, un effet chimiothérapeutique de ces nanoparticules a été observé in vitro et in vivo. Par contre, le mécanisme précis de cet effet est encore à être expliquer, mais on sait déjà que les nanoparticules d'or affectent les fonctions des macrophages ainsi que l'angiogenèse. MOTS-CLÉS : Radiosensibilisateur, Nanoparticules d'or, Agent de contraste pour l'IRM, Électrons de basses énergies, Kaplan-Meier, Effet chimiothérapeutique.

  10. Protease activated receptor-2 (PAR2): possible target of phytochemicals.

    PubMed

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-09-01

    The use of phytochemicals either singly or in combination with other anticancer drugs comes with an advantage of less toxicity and minimal side effects. Signaling pathways play central role in cell cycle, cell growth, metabolism, etc. Thus, the identification of phytochemicals with promising antagonistic effect on the receptor/s playing key role in single transduction may have better therapeutic application. With this background, phytochemicals were screened against protease-activated receptor 2 (PAR2). PAR2 belongs to the superfamily of GPCRs and is an important target for breast cancer. Using in silico methods, this study was able to identify the phytochemicals with promising binding affinity suggesting their therapeutic potential in the treatment of breast cancer. The findings from this study acquires importance as the information on the possible agonists and antagonists of PAR2 is limited due its unique mechanism of activation. PMID:25386994

  11. Identification of irradiated foods

    SciTech Connect

    Morehouse, K.M.

    1992-01-01

    A reliable method is needed to determine if foods have been irradiated and are in compliance with respect to the allowable absorbed radiation dose. Several approaches for the identification of irradiated foods are under development worldwide. These include measurement of o-tyrosine, radiolytically generated hydrocarbons from lipids and chemiluminescence or thermoluminescence, and the use of electron spin resonance (ESR) to measure free radicals trapped in calcified tissues. This paper describes the efforts being undertaken at the FDA to develop analytical procedures to monitor and identify foods that have been treated with ionizing radiation. In particular, it focuses on the use of an ESR approach to measure radiation-induced free radicals trapped in calcified tissues and the use of a capillary gas chromatography (GC)-based procedure to determine radiolytically generated hydrocarbons formed by the radiolysis of lipids in various foods.

  12. MSc Conservation The leading degree for aspiring

    E-print Network

    Jones, Peter JS

    MSc Conservation The leading degree for aspiring nature conservation professionals www.geog.ucl.ac.uk/conservation LONDON'S GLOBAL UNIVERSITY #12;Student fieldwork, Norfolk (Picture: Jan Axmacher) Conservation at UCL The UCL MSc Conservation is widely recognised as the leading course for aspiring nature conservation

  13. The centromere-like parC locus of plasmid R1.

    PubMed

    Breüner, A; Jensen, R B; Dam, M; Pedersen, S; Gerdes, K

    1996-05-01

    The parA partitioning system of plasmid R1 consists of three components: the cis-acting centromere-like parC locus, and two proteins, ParM and ParR. The parC locus contains two sets of five direct repeats (iterons) to which the ParR protein binds. The parA promoter is located in the core region between the two sets of iterons. Mini-R1 replicons carrying parC are stabilized by the simultaneous presence of ParM and ParR. The parC locus present on a co-resident plasmid leads to instability of the mini-R1 replicon (incompatibility). Here we present a genetic analysis of the stability and incompatibility phenotypes associated with parC. We show that all 10 iterons are required for maximum stabilization and incompatibility. Replacement of the core promoter region between the repeats by a foreign promoter region did not reduce stabilization. Thus, the only structural components in parC seem to be the two sets of iterons. The parA promoter, P parA, is repressed by ParR. We show that all 10 iterons are required for full repression of the promoter. The activity of the promoter was influenced by sequences located outside the core region. An A-rich region located upstream of the -35 element of PparA was found to increase promoter activity. The region encoding the parA mRNA leader region also strongly influenced the expression level of PparA- lacZ fusions. We show that this high expression (hex) element is a transcriptional antiterminator that prevents Rho-dependent termination. PMID:8736537

  14. Competing ParA Structures Space Bacterial Plasmids Equally over the Nucleoid

    PubMed Central

    Gerdes, Kenn; Howard, Martin

    2014-01-01

    Low copy number plasmids in bacteria require segregation for stable inheritance through cell division. This is often achieved by a parABC locus, comprising an ATPase ParA, DNA-binding protein ParB and a parC region, encoding ParB-binding sites. These minimal components space plasmids equally over the nucleoid, yet the underlying mechanism is not understood. Here we investigate a model where ParA-ATP can dynamically associate to the nucleoid and is hydrolyzed by plasmid-associated ParB, thereby creating nucleoid-bound, self-organizing ParA concentration gradients. We show mathematically that differences between competing ParA concentrations on either side of a plasmid can specify regular plasmid positioning. Such positioning can be achieved regardless of the exact mechanism of plasmid movement, including plasmid diffusion with ParA-mediated immobilization or directed plasmid motion induced by ParB/parC-stimulated ParA structure disassembly. However, we find experimentally that parABC from Escherichia coli plasmid pB171 increases plasmid mobility, inconsistent with diffusion/immobilization. Instead our observations favor directed plasmid motion. Our model predicts less oscillatory ParA dynamics than previously believed, a prediction we verify experimentally. We also show that ParA localization and plasmid positioning depend on the underlying nucleoid morphology, indicating that the chromosomal architecture constrains ParA structure formation. Our directed motion model unifies previously contradictory models for plasmid segregation and provides a robust mechanistic basis for self-organized plasmid spacing that may be widely applicable. PMID:25521716

  15. Detection of irradiated food

    Microsoft Academic Search

    W. G. Hein; T. J. Simat; H. Steinhart

    2000-01-01

    o-Tyrosine is proposed as a marker for the identification of irradiated protein-rich food. The disadvantages of most of the\\u000a published methods are insufficient selectivity and the relatively high values of o-tyrosine in unirradiated samples. A method for the analysis of non-protein-bound o-tyrosine in common shrimps is presented here. The procedure involves the homogenization of fresh shrimps followed by solvent\\u000a precipitation

  16. Modelling the Establishment of PAR Protein Polarity in the One-Cell C. elegans Embryo

    E-print Network

    Filipe Tostevin; Martin Howard

    2008-11-20

    At the one-cell stage, the C. elegans embryo becomes polarized along the anterior-posterior axis. The PAR proteins form complementary anterior and posterior domains in a dynamic process driven by cytoskeletal rearrangement. Initially, the PAR proteins are uniformly distributed throughout the embryo. Following a cue from fertilization, cortical actomyosin contracts towards the anterior pole. PAR-3/PAR-6/PKC-3 (the anterior PAR proteins) become restricted to the anterior cortex. PAR-1 and PAR-2 (the posterior PAR proteins) become enriched in the posterior cortical region. We present a mathematical model of this polarity establishment process, in which we take a novel approach to combine reaction-diffusion dynamics of the PAR proteins coupled to a simple model of actomyosin contraction. We show that known interactions between the PAR proteins are sufficient to explain many aspects of the observed cortical PAR dynamics in both wild-type and mutant embryos. However, cytoplasmic PAR protein polarity, which is vital for generating daughter cells with distinct molecular components, cannot be properly explained within such a framework. We therefore consider additional mechanisms that can reproduce the proper cytoplasmic polarity. In particular we predict that cytoskeletal asymmetry in the cytoplasm, in addition to the cortical actomyosin asymmetry, is a critical determinant of PAR protein localization.

  17. ParA-mediated plasmid partition driven by protein pattern self-organization

    PubMed Central

    Hwang, Ling Chin; Vecchiarelli, Anthony G; Han, Yong-Woon; Mizuuchi, Michiyo; Harada, Yoshie; Funnell, Barbara E; Mizuuchi, Kiyoshi

    2013-01-01

    DNA segregation ensures the stable inheritance of genetic material prior to cell division. Many bacterial chromosomes and low-copy plasmids, such as the plasmids P1 and F, employ a three-component system to partition replicated genomes: a partition site on the DNA target, typically called parS, a partition site binding protein, typically called ParB, and a Walker-type ATPase, typically called ParA, which also binds non-specific DNA. In vivo, the ParA family of ATPases forms dynamic patterns over the nucleoid, but how ATP-driven patterning is involved in partition is unknown. We reconstituted and visualized ParA-mediated plasmid partition inside a DNA-carpeted flowcell, which acts as an artificial nucleoid. ParA and ParB transiently bridged plasmid to the DNA carpet. ParB-stimulated ATP hydrolysis by ParA resulted in ParA disassembly from the bridging complex and from the surrounding DNA carpet, which led to plasmid detachment. Our results support a diffusion-ratchet model, where ParB on the plasmid chases and redistributes the ParA gradient on the nucleoid, which in turn mobilizes the plasmid. PMID:23443047

  18. Conserving Water at Home

    NSDL National Science Digital Library

    Humans depend on freshwater for drinking as well as for domestic, agricultural, and industrial uses. Careless and wasteful use of this renewable but high-demand natural resource contributes to water depletion. This video segment provides a look at a house in Tuscon, Arizona that is equipped with water conservation devices that cut its household water consumption in half. There is also discussion of xeriscape landscaping techniques and a program to install low-flow toilets in Los Angeles, California. The segment is two minutes fifty-seven seconds in length. A background essay and discussion questions are included.

  19. Water Conservation: Israel

    NSDL National Science Digital Library

    A recent report stated that in the next decade or so, nearly half of the world's population will live in countries whose water supplies are over-stressed. In parts of Africa, northern China, southern Asia, and the Middle East, water is already being pumped from aquifers faster than it is being replenished. In India, the water table is falling 1-3 m (3-10 ft) per year. This video segment, adapted from the television program 'Last Oasis', discusses how Israel has approached its water scarcity problem by developing innovative ways to conserve and reuse its supply.

  20. Water Conservation: Denver, CO

    NSDL National Science Digital Library

    Dams are widely distributed throughout the U.S. Their impact is perhaps most apparent in western cities, many of which lack a sufficient local water supply and thus rely on water diverted from far-away sources, particularly man-made lakes. This video segment shows how the city of Denver, Colorado, faced with a growing water crisis, developed and later abandoned a plan for a nearby dam and instead adopted policies consistent with a broader water-conservation strategy. The segment is three minutes forty-nine seconds in length.

  1. Conservation of Energy

    NSDL National Science Digital Library

    Stern, David P. (David Peter), 1931-

    This lesson plan, authored and curated by David P. Stern, introduces the concept of energy through the ideas of conservation and the ability to run machines. A series of both qualitative and quantitative examples are used to explore different forms of energy and transformations between them. Starting with and focusing on mechanical energy, examples regarding chemical energy, electrical energy, and heat are included. This is part of the larger site "From Stargazers to Starships", and includes a link to the Energy chapter in this online text.

  2. Integrating Agriculture and Conservation

    USGS Publications Warehouse

    Vandever, Mark W.

    2010-01-01

    The USGS produces the needed science-based information to guide management actions and policy decisions that support wildlife habitat and other environmental services compatible with USDA conservation goals and farm operations. The Policy Analysis and Science Assistance Branch of the Fort Collins Science Center (FORT) has conducted research involving a national landowner survey and numerous short- and long-term evaluations regarding vegetation responses to land management practices. This research helps land and resource managers to make informed decisions and resolve resource management conflicts.

  3. Identification and characterization of yeasts causing chalk mould defects on par-baked bread.

    PubMed

    Deschuyffeleer, N; Audenaert, K; Samapundo, S; Ameye, S; Eeckhout, M; Devlieghere, F

    2011-08-01

    Pichia anomala, Hyphopichia burtonii and Saccharomycopsis fibuligera are spoilage yeasts causing chalk mould defects on par-baked breads packaged under modified atmosphere. The first objective of this study was to identify yeasts isolated from spoiled par-baked breads by means of a RAPD protocol and to determine the dominant spoilers amongst identified strains. The second objective was to determine the effects of water activity (a(w)) and pH value on the growth rates and lag phase durations of P. anomala, H. burtonii and S. fibuligera. 95% of the yeasts tested were identified as P. anomala and 5% as S. fibuligera, H. burtonii was not detected. In order to investigate the effect of a(w) and pH the growth of the three yeasts was tested within an a(w) range of 0.88-0.98 and a pH range of 2.8-8.0. P. anomala was able to grow from pH 2.8 to 8 without a clear optimum. S. fibuligera and H. burtonii showed a pH optimum for growth of 5. The optimum water activity for growth was different for the three strains and varied between 0.96 and 0.98. These growth data were further used to develop secondary models that describe the relationship between a(w) and the radial or colony growth rate (g, mm/d) or the lag phase duration (?, d). The identification of the spoilage organisms and a good understanding of the effects of a(w) and pH on the growth behavior is essential for future development of adequate conservation strategies against chalk mould defects. PMID:21569947

  4. Reducing Second Breast Cancers: A Potential Role for Prophylactic Mammary Irradiation

    E-print Network

    Brenner, David Jonathan

    patients9-11 who underwent radiotherapy show large radiation-induced breast cancer risks at sites exposedReducing Second Breast Cancers: A Potential Role for Prophylactic Mammary Irradiation David J of California Berkeley, Berkeley, CA Breast-conserving surgery followed by radiotherapy is the standard of care

  5. Supply Curves of Conserved Energy

    SciTech Connect

    Meier, Alan Kevin

    1982-05-01

    Supply curves of conserved energy provide an accounting framework that expresses the potential for energy conservation. The economic worthiness of a conservation measure is expressed in terms of the cost of conserved energy, and a measure is considered economical when the cost of conserved energy is less than the price of the energy it replaces. A supply curve of conserved energy is independent of energy prices; however, the economical reserves of conserved energy will depend on energy prices. Double-counting of energy savings and error propagation are common problems when estimating conservation potentials, but supply curves minimize these difficulties and make their consequences predictable. The sensitivity of the cost of conserved energy is examined, as are variations in the optimal investment strategy in response to changes in inputs. Guidelines are presented for predicting the consequences of such changes. The conservation supply curve concept can be applied to peak power, water, pollution, and other markets where consumers demand a service rather than a particular good.

  6. FDA perspective on food irradiation

    SciTech Connect

    Pauli, G.H.

    1994-12-31

    The Center for Food Safety and Applied Nutrition (CFSAN) monitors the safety of food irradiation. A few limited uses are regulated, and occasionally CFSAN receives a petition for a new use. Despite extensive studies (more than 400) showing the safety of food irradiation, a cloud of suspicion continues to hang over this issue in the mind of the public. People perceive food irradiation and direct body irradiation as having similar implications. Food irradiation is banned in two states in the United States. Food is irradiated for the following purposes: delay of ripening, prevention of sprouting, eradication of pests and sterilization, and allowing commodities to be stored unrefrigerated for long periods of time. The dosage depends on the purpose of the irradiation. Radiolytic products are formed during irradiation and during storage afterward. Most of these products are also formed during conventional preservation. In 1980, CFSAN, then the Bureau of Foods, introduced the term unique radiolytic products for compounds not identified in foods after conventional processing. Although the existence of URPs was never proven chemically, the term has caused anxiety. Irradiation of foods in the commercially useful range does not generate radioactivity above natural background. Because radiolytic products formed from beef, chicken, and pork are primarily the same, irradiated foods of similar food groups may be evaluated generically.

  7. Energy conservation in museums

    SciTech Connect

    Ucar, M.; Doering, G.C.

    1980-07-01

    An overall assessment of energy conservation in museums in New York is made in view of the special environmental considerations involved. The special relative humidity, temperature, and lighting requirements of museums were studied extensively. An energy consumption data base was formed with actual energy use data obtained from over fifty institutions across the state. The computerized energy consumption data base compiled covers an extremely wide range of energy usage levels. On-site energy consumption ranged from approximately 20,000 to 400,000 Btu/ft/sup 2/ year. The data base includes small rural institutions and large metropolitan museums, historic and modern structures, seasonal and year-round museums, single buildings and collections of buildings, single-story buildings and multiple-story buildings, an aquarium, and a zoo. Thus, it is difficult to identify trends in the energy consumption data and to make correlations with such parameters as age, type, size, etc. Walk-through or mini energy audits were performed on ten museums located in various parts of New York State. This project also included a thorough study of all potential funding sources to which museums can apply for financing energy conservation measures. Sources of technical assistance and information were also identified. (MCW)

  8. Integrable viscous conservation laws

    NASA Astrophysics Data System (ADS)

    Arsie, Alessandro; Lorenzoni, Paolo; Moro, Antonio

    2015-06-01

    We propose an extension of the Dubrovin–Zhang perturbative approach to the study of normal forms for non-Hamiltonian integrable scalar conservation laws. The explicit computation of the first few corrections leads to the conjecture that such normal forms are parameterized by one single functional parameter, named the viscous central invariant. A constant valued viscous central invariant corresponds to the well-known Burgers hierarchy. The case of a linear viscous central invariant provides a viscous analog of the Camassa–Holm equation, that formerly appeared as a reduction of two-component Hamiltonian integrable systems. We write explicitly the negative and positive hierarchy associated with this equation and prove the integrability showing that they can be mapped respectively into the heat hierarchy and its negative counterpart, named the Klein–Gordon hierarchy. A local well-posedness theorem for periodic initial data is also proven. We show how transport equations can be used to effectively construct asymptotic solutions via an extension of the quasi-Miura map that preserves the initial datum. The method is alternative to the method of the string equation for Hamiltonian conservation laws and naturally extends to the viscous case. Using these tools we derive the viscous analog of the Painlevé I2 equation that describes the universal behaviour of the solution at the critical point of gradient catastrophe.

  9. Lyme disease and conservation

    USGS Publications Warehouse

    Ginsberg, H.

    1994-01-01

    Lyme disease is a tick-borne illness that is wide-spread in North America, especially in the northeastern and northcentral United States. This disease could negatively influence efforts to conserve natural populations in two ways: (1) the disease could directly affect wild animal health; and (2) tick control efforts could adversely affect natural populations and communities. Lyme disease affects several domestic animals, but symptoms have been reported in only a few wild species. Direct effects of Lyme disease on wild animal populations have not been reported, but the disease should be considered as a possible cause in cases of unexplained population declines in endemic areas. Methods available to manage ticks and Lyme disease include human self-protection techniques, manipulation of habitats and hosts species populations, biological control, and pesticide applications. The diversity of available techniques allows selection of approaches to minimize environmental effects by (1) emphasizing personal protection techniques, (2) carefully targeting management efforts to maximize efficiency, and (3) integrating environmentally benign techniques to improve management while avoiding broad-scale environmentally destructive approaches. The environmental effects of Lyme disease depend, to a large extent, on the methods chosen to minimize human exposure to infected ticks. Conservation biologists can help design tick management programs that effectively lower the incidence of human Lyme disease while simultaneously minimizing negative effects on natural populations.

  10. Redshift and Energy Conservation

    E-print Network

    Alasdair Macleod

    2004-08-06

    It has always been considered a serious error to treat the cosmological redshift as a Doppler velocity effect rather than the result of space expansion. It is demonstrated here that in practical terms this is not the case, and that the apparent distance - redshift relation derived from a Doppler interpretation is reasonably consistent with supernova data (though not as good as the standard model with dark energy). The normal Doppler effect is examined in detail and shown to conserve energy as expected. Because of the equivalence between the general relativistic space expansion paradigm and the Doppler effect (as demonstrated) the long-standing problem of energy loss associated with the expansion of the Universe is treated in a similar manner to the normal well-behaved Doppler effect. The mechanism by which energy is conserved with the normal Doppler shift is applied to the cosmological redshift and the energy violation disappears. However, an additional luminosity-dependent recession factor is introduced. The effect on astronomical objects is examined and it is found to add only a small additional redshift to a body generating power by nuclear means but can be very large for objects powered by gravity. A possible connection to the claimed anomalous redshift of quasars is considered.

  11. Subthalamic Stimulation-Induced Synaptic Responses in Substantia Nigra Pars Compacta Dopaminergic Neurons In Vitro

    E-print Network

    Tepper, James M.

    Subthalamic Stimulation-Induced Synaptic Responses in Substantia Nigra Pars Compacta Dopaminergic. Subthalamic stimulation-induced synaptic responses in sub- stantia nigra pars compacta dopaminergic neurons sources of excitatory glutamatergic input to dopaminer- gic neurons of the substantia nigra, yet

  12. PHNOMNES LECTRIQUES DES CRISTAUX HMIDRES A FACES INCLINES ; PAR MM. JACQUES ET PIERRE CURIE.

    E-print Network

    Paris-Sud XI, Université de

    par un exemple : les cris- taux de tourmaline ont un axe électrique qui coïncide avec l'axe principal'électricité sue les deux bases. Dans le cas de la tourmaline, les phénomènes électriques sont de même sens par

  13. Cette hypothse a t confirme par une srie d'essais. Des effets analogues

    E-print Network

    Paris-Sud XI, Université de

    provoqués par la vaseline au silicone, mais également par la lanoline. On n'a pas constaté de toxicité aiguë de la vaseline au silicone ou de la lanoline. Les abeilles transportent sur les rayons la graisse

  14. son tat molculaire primitif, par suite de l'existence de ce frotte-ment interne ;

    E-print Network

    Boyer, Edmond

    décrément logarithmique et par suite le frottement interne subissent des accroissements très rapides vers 55443 son état moléculaire primitif, par suite de l'existence de ce frotte- ment interne ; 2° Que le

  15. Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.

    PubMed

    Alvarez, James V; Pan, Tien-Chi; Ruth, Jason; Feng, Yi; Zhou, Alice; Pant, Dhruv; Grimley, Joshua S; Wandless, Thomas J; Demichele, Angela; Chodosh, Lewis A

    2013-07-01

    Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor recurrence and that Par-4 downregulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor response to neoadjuvant chemotherapy and an increased risk of relapse in patients with breast cancer, and Par-4 is downregulated in residual tumor cells that survive neoadjuvant chemotherapy. Our findings identify Par-4-induced multinucleation as a mechanism of cell death in oncogene-addicted cells and establish Par-4 as a negative regulator of breast cancer recurrence. PMID:23770012

  16. National Association of Conservation Districts

    NSDL National Science Digital Library

    The idea of creating conservation districts through the support of private landowners was one that had gestated for decades before the National Association of Conservation Districts (NACD) was formed in 1946. Currently, there are over 3000 conservation districts throughout the United States, and the NACD effectively acts as a unified voice that represents the interests of these districts and also helps develop national conservation policies and fruitful partnerships with other agencies and organizations. First-time visitors to the site will want to perhaps go to the directory section to learn more about the NACD and look through the site's interactive map to learn about where the various conservation districts are located. Students and practitioners may want to look through the electronic publications area, which includes such helpful materials as the organization's in-house weekly news briefs (called eNotes) and their publications produced through effective joint-partnerships, such as Forestry Notes and Conservation.

  17. The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments

    Microsoft Academic Search

    Jeanne Salje; Pananghat Gayathri; Jan Löwe

    2010-01-01

    The ParMRC plasmid partitioning apparatus is one of the best characterized systems for bacterial DNA segregation. Bundles of actin-like filaments are used to push plasmids to opposite poles of the cell, whereupon they are stably inherited on cell division. This plasmid-encoded system comprises just three components: an actin-like protein, ParM, a DNA-binding adaptor protein, ParR, and a centromere-like region, parC.

  18. gulires signales par Buttgenbach et Gaubert [5] et qui se dvelopperaient ici lorsque les invitables

    E-print Network

    Paris-Sud XI, Université de

    -optique, appelée r41 par Cady [3] et e,, par Pockels, est donnée par la formule ([2], p. 67). E = V/d désignant le champ électrique, -,ri' la suscep-d tibilité électrique à tension constante (que Pockels désigne par x, 37I). [2] POCKELS F. - Abhandl. der Gesell. Wiss. Göttingen, I893, 39, 40. [3] CADY

  19. Hes1 regulates formations of the hypophyseal pars tuberalis and the hypothalamus

    Microsoft Academic Search

    Minekatsu Akimoto; Toshiyuki Nishimaki; Yuta Arai; Eiju Uchinuma; Hiroshi Yamauchi; Yoko Kameda

    2010-01-01

    The hypophyseal pars tuberalis surrounds the median eminence and infundibular stalk of the hypothalamus as thin layers of\\u000a cells. The pars tuberalis expresses MT1 melatonin receptor and participates in mediating the photoperiodic secretion of pituitary\\u000a hormones. Both the rostral tip of Rathke’s pouch (pars tuberalis primordium) and the pars tuberalis expressed ?GSU mRNA, and\\u000a were immunoreactive for LH, chromogranin A,

  20. Impact of enhanced ultraviolet-B irradiance on maize yield formation and structure: a field evaluation

    NASA Astrophysics Data System (ADS)

    Gao, Wei; Zheng, Youfei; Slusser, James R.; He, Yuhong; Zhang, Ronggang

    2003-11-01

    Stratospheric ozone depletion and enhanced solar ultraviolet-B (UV-B) irradiance may have adverse impacts on the productivity of agricultural crops. Though only a small portion of the total solar electromagnetic spectrum, UV-B irradiance has a disproportionately large photobiological effect, largely because it is readily absorbed by important macromolecules such as proteins and nucleic acids. Numerous investigations have demonstrated that the effect of UV-B enhancements on plants includes a reduction in grain yield, alteration in species competition, susceptibility to disease, and changes in plant structure and pigmentation. Many experiments examining UV-B radiation effects on plants were conducted in growth chambers or greenhouses. It has been questioned if the effect of UV-B radiation on plants can be extrapolated to field responses from indoor studies because of the unnaturally high ratios of UV-B/UV-A and UV-B/PAR in many indoor studies. Field studies on UV-B radiation effect on plants have been recommended in order to use the UV and PAR irradiance provided by natural light. This study found the maize yield formation and yield structural elements responded to enhanced UV-B radiation under field conditions. Enhanced UV-B radiation caused a significant reduction of the dry matter accumulation and the maize grain yield in turn was affected. Analysis of yield structure indicates that the maize yield decreased with increased UV-B radiation and was evidently related to the decreased kernel weight and kernel number per ear.

  1. ALCALOSE INDUITE PAR LE NITRATE CHEZ LA POULE

    E-print Network

    Paris-Sud XI, Université de

    ALCALOSE INDUITE PAR LE NITRATE CHEZ LA POULE ET CARACTÉRISTIQUES DE L'ŒUF B. SAUVEUR Mme H'alcalose chez les Mammifères, exerce la même action chez la Poule et modifie les caractéristiques de l'oeuf. Ce'oeuf les réponses varient suivant le génotype des animaux : chez des poules White Leghorn, la restriction

  2. L'valuation du prix des actions par les fondamentaux

    E-print Network

    Paris-Sud XI, Université de

    L'évaluation du prix des actions par les fondamentaux : analyse du marché français Dominique Pépin(*) Depuis 1920, le prix des actions en France, comme partout dans le monde, a connu d'importantes variations des banques centrales, et à se demander si ces dernières ne devaient pas prendre en compte le prix des

  3. SUR LA FLUORESCENCE ROUGE DU VERRE Par L. BRUNINGHAUS.

    E-print Network

    Boyer, Edmond

    SUR LA FLUORESCENCE ROUGE DU VERRE Par L. BRUNINGHAUS. Sommaire. - Cette note est consacrée à l. - Ayant eu récemment l'occasion de lire un mémoire de H. Peters sur la fluorescence rouge du verre, j cathodiques lents, des parois de verre contenant de l'oxygène occlus. E. Goldstein (2) indiqua en 1906 qu

  4. OSCILLATION D'UN JET LIQUIDE Par GUY LITTAYE.

    E-print Network

    Boyer, Edmond

    à l'extrémité d'un tube de verre court. Le liquide, l'eau en l'espèce, est amené au tube de verre par un tube de caoutchouc. Le tube de verre est fixé sur une lame d'acier qui effectue des observer exception- nellement un aspect semblable du jet alors que le tube de verre était soigneusement

  5. Traumatismes Oculaires par Petards: Bilan sur Trois Annees

    PubMed Central

    Zouaoui-Kesraoui, N.; Derdour, A.

    2009-01-01

    Summary Les accidents dus aux pétards sont des accidents graves. Leur recrudescence ces dernières années en Algérie, essentiellement durant les fêtes du Mawlid Ennabaoui (fête de la naissance du prophète), mérite à notre sens d'entreprendre des bilans exhaustifs dont celui-ci dans le but d'une sensibilisation de toutes les compétences concernées. Nous avons réuni sur trois années consécutives (2002, 2003, 2004) 60 dossiers de malades ayant subi des accidents oculaires par pétards. Nos patients sont répartis en 42 consultations pour blessures légères et 18 hospitalisations pour blessures graves. Parmi ces derniers, neuf ont présenté des complications et séquelles graves (cinq cas de cécité par atrophie du globe oculaire, trois cas de cécité cornéenne et un cas de cécité par trou maculaire). Dans tous ces cas l'incapacité permanente partielle est au minimum de 30%. Au vu de ces données nous proposons des mesures d'éducation sanitaire et une sensibilisation du grand public aux traumatismes oculaires, par le biais de mé dias appropriés: radio, télévision, affiches. PMID:21991157

  6. INFECTION EXPRIMENTALE DU BLIER PAR SALMONELLA ABORTUS OVIS

    E-print Network

    Paris-Sud XI, Université de

    INFECTION EXPÉRIMENTALE DU BÉLIER PAR SALMONELLA ABORTUS OVIS R. SANCHIS P. PARDON2 Georgette, France Summary EXPERIMENTAL INFECTION OF RAM WITH SALMONELLA ABORTUS OVIS. - The susceptibility of rams to experimental challenge with Salmonella abortus ovis was investigated by subcutaneous, conjunctival or preputial

  7. Leucémie aigüe myélomonocytaire à éosinophiles révélée par une pancréatite aigüe

    PubMed Central

    Touaoussa, Aziz; Elhmadi, Khalid; El Youssi, Hind; Moncef, Hichameddou; Hassani, Moncef Amrani

    2015-01-01

    La leucémie aigüe myélomonocytaire à composante éosinophile (LAM4eo) est une hémopathie maligne rare, caractérisée par une prolifération blastique myéloïde avec présence d'une composante monocytaire et des éosinophiles anormaux. Elle est associée à l'inversion du chromosome 16, parfois à sa variante la translocation (16;16). Nous rapportons un cas de LAM4eo chez un patient de sexe masculin âgé de 51 ans, découverte au décours d'un bilan paraclinique pour pancréatite aiguë (PA) confirmée par la TDM. L'hémogramme a montré une hyperleucocytose à 123G/l faite de 60% de blastes, une monocytose à 5 G/L ainsi qu'une lignée éosinophile dystrophique. Le myélogramme a objectivé l'infiltration de la moelle par une population blastique estimée à 61% d'expression hétérogène à la Cytométrie de flux: Des blastes très immatures exprimant fortement les marqueurs CD117 et CD34; des blastes prédominants qui expriment les antigènes CD33, CD13, CD65 (myéloblastes). Et une partie des blastes, était positive pour le CD14, CD4, CD11c (monoblastes). Après une exploration étiologique approfondie n'ayant pas pu trouver un lien de cause à effet, l'association entre les deux pathologies a été considérée comme fortuite et la pancréatite a été rattachée à la prise de paroxétine. Le patient a été mis alors en condition, et a été traité par chimiothérapie avec bonne évolution clinique et biologique. PMID:26090060

  8. DCLENCHEMENT DE LA MASTICATION PAR DISTENSION ŒSOPHAGIENNE CHEZ LE MOUTON

    E-print Network

    Boyer, Edmond

    DÉCLENCHEMENT DE LA MASTICATION PAR DISTENSION ŒSOPHAGIENNE CHEZ LE MOUTON R. BOIVIN, J. BOST IN SHEEP. ― !sophageal wall disten- sion was performed on standing conscious sheep by inflating of the regurgitated bolus into the mouth. La mastication est, le plus souvent, un acte réflexe qui suit l

  9. AIMANTATION SPONTANE DES FERRITES Par REN PAUTHENET et L. BOCHIROL.

    E-print Network

    Paris-Sud XI, Université de

    également étudié la variation thermique de l'aimantation spontanée des ferrites de nickel, de cobalt et deAIMANTATION SPONTANÉE DES FERRITES Par RENÉ PAUTHENET et L. BOCHIROL. Sommaire. 2014 Les auteurs ont étudié les variations de l'aimantation à saturation des ferrites de magnésium et de cuivre en

  10. ANOMALIE DE LONGUEUR DES FERRITES Par LOUIS WEIL.

    E-print Network

    Paris-Sud XI, Université de

    ferrites de cuivre, de nickel, de cobalt, de zinc et de magnésium, entre la température ordinaire et 900° CANOMALIE DE LONGUEUR DES FERRITES Par LOUIS WEIL. Sommaire. - L'auteur a étudié la dilatation des étudié au dilatomètre Chevenard divers ferrites. Lorsqu'on fait varier la température assez lentement

  11. Histoire(de(l'Astronomie( par(Thomas(Widemann((

    E-print Network

    Demoulin, Pascal

    (ses(observations.(Dans(son(oeuvre,( "l'Almageste",(ainsi(dénommée(par(les( Arabes,(il(présente(son(système( géocentrique(du(centre(de(l'épicycle(est(uniforme.(( Almageste (grec, IXe siècle)! Almageste (latin, XIII-XIVe siècle)! L'astronomie(araboIislamique( ( Parmi

  12. The Pars Triangularis in Dyslexia and ADHD: A Comprehensive Approach

    ERIC Educational Resources Information Center

    Kibby, Michelle Y.; Kroese, Judith M.; Krebbs, Hillery; Hill, Crystal E.; Hynd, George W.

    2009-01-01

    Limited research has been conducted on the structure of the pars triangularis (PT) in dyslexia despite functional neuroimaging research finding it may play a role in phonological processing. Furthermore, research to date has not examined PT size in ADHD even though the right inferior frontal region has been implicated in the disorder. Hence, one…

  13. Clinical and immunopathological studies of pars planitis in a family.

    PubMed Central

    Wetzig, R P; Chan, C C; Nussenblatt, R B; Palestine, A G; Mazur, D O; Mittal, K K

    1988-01-01

    We examined a family in which two brothers with identical HLA typing have pars planitis with snowbanking. Immunopathological studies of one of their eyes showed that in the area of snowbanking over the pars plana there was mild to moderate inflammatory cell infiltration, consisting of mostly Pan T (Leu 4+) lymphocytes. The ratio of T helper/inducer to T suppressor/cytotoxic cells was approximately 10:1. Few macrophages (OKM1+) were identified. Very few B cells and no NK cells were observed. Some retinal vessels had a perivascular infiltration consisting of mostly T lymphocytes. Most of the inflammatory cells bore class II antigens (HLA-DR+), while T cells bore few IL-2 receptors (anti-TAC+). The snowbank consisted mainly of glial elements (GFAP+) and basement membrane components (type IV collagen and laminin) with the predominant cell the Müller cell (Mü+). A site of inflammation at the iris-ciliary body junction also stained for B cells (Leu 14+). These findings suggest that the snowbank could be formed by the glial elements of the peripheral retina. The chronic inflammation in pars planitis appears to consist of helper T cells, both in the pars plana, and the retinal vasculature. Images PMID:3257703

  14. Berkeley ParLab Ten Ways to Waste a Parallel

    E-print Network

    Moreno Maza, Marc

    2005 2010 Transistors (in Thousands) Data from Kunle Olukotun, Lance Hammond, Herb Sutter, Burton Smith, Lance Hammond, Herb Sutter, Burton Smith, Chris Batten, and Krste Asanoviç #12;Berkeley Par) Frequency (MHz) Power (W) Perf Cores Data from Kunle Olukotun, Lance Hammond, Herb Sutter, Burton Smith

  15. INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE N attribu par la bibliothque

    E-print Network

    Paris-Sud XI, Université de

    , Traitement du Signal présentée et soutenue publiquement par Luis ROLINDEZ le 23 février 2007 Titre : Technique d'auto test pour des convertisseurs de signal Sigma-Delta Directeur de thèse : Salvador MIR Co M. Andreas KAISER , Rapporteur M. Salvador MIR , Directeur de thèse M. Jean-Louis CARBONERO , Co

  16. Dtection de Pseudomonas phaseolicola (Burkh.) Dowson par la technique ELISA

    E-print Network

    Paris-Sud XI, Université de

    Détection de Pseudomonas phaseolicola (Burkh.) Dowson par la technique ELISA Marie-Renée BARZIC des feuilles contaminées de haricot. ELISA, Le test EusA a été réalisé selon la méthode sandwich d. phaseolicola comme ligand (fig. 1). Métabolites, ' Des études préalables ont montré que la technique ELISA

  17. Scheduling on the MasPar SIMD parallel computer

    E-print Network

    Perkins, Keith Douglas

    1995-01-01

    whose scheduling times are within 90% of optimal schedules 95% of the time. The highest level first algorithm was then modifies to handle the processor architecture on the Texas A&M University's MasPar parallel computer. These modifications included...

  18. Aqueous misdirection following pars plana vitrectomy and silicone oil injection

    PubMed Central

    Ghoraba, Hammouda H; Ghali, Ali Ahmed; Mansour, Hosam Othman

    2015-01-01

    Purpose To report a retrospective series of seven phakic eyes of seven patients suffering from a malignant glaucoma-like syndrome following pars plana vitrectomy and silicone oil (SO) injection. Materials and methods Seven eyes with retinal detachment treated with pars plana vitrectomy with or without scleral buckling with SO tamponade. This was followed by cataract extraction to manage the elevated intraocular pressure (IOP). Results This was a retrospective review of seven cases that received pars plana vitrectomy and SO with or without scleral buckling for different causes of retinal detachment (three were rhegmatogenous and four were tractional). After a period ranging from 1 week to 1 month, they presented with malignant glaucoma-like manifestations; high IOP, shallow axial anterior chamber, and remarkable decrease of visual acuity. Atropine eye drops and anti-glaucoma medical treatment (topical and systemic) had been tried but failed to improve the condition. Dramatic decrease of IOP and deepening of the axial anterior chamber was observed in all cases in the first postoperative day after phacoemulsification and posterior chamber foldable intraocular lens implantation with posterior capsulotomy. Conclusion Aqueous misdirection syndrome may be observed following pars plana vitrectomy and SO tamponade. This must be differentiated from other causes of post vitrectomy glaucoma. Cataract extraction with posterior capsulotomy controls the condition. PMID:26056429

  19. SUR LE PARAMAGNTISME DU MANGANSE Par Mlle A. SERRES.

    E-print Network

    Paris-Sud XI, Université de

    présentaient même un faible ferromagnétisme. Depuis les travaux de Miss Gayler (4) on sait pré- parer du) a vérifié que -le manganèse très pur obtenu par Miss Gayler ne présentait aucune trace de ferro- magnétisme, A .13~., p. 266. 1 (8) SHIMIZU. Sc. Rep. Tohoku Imp. 1930,19, p. 411. (7) GRUBE et WINKLER. Z

  20. Filtrage de bioprocede de depollution. Approche par convolution particulaire.

    E-print Network

    Rossi, Vivien

    ´erobie mod´elis´ee par une approche bilan-mati`ere. A. Mod´elisation de la bior´eaction Ce mod`ele est de´etis´ee, selon le sch´ema d'Eu- ler, de ce mod`ele d'EDO. B. Description des variables Toutes les variables d

  1. INSTITUT POLYTECHNIQUE DE GRENOBLE attribue par la biblioth`eque

    E-print Network

    Paris-Sud XI, Université de

    , pour son agr´eable compagnie et les courses `a pied qu'on a partag´ees. Mes co-bureaux, Jordi et Pepa, pour leur amiti´e et tous les discussions et repas par- tag´es. Nicolas, Julien, pour... le Roy Nock

  2. LES MOLCULES DANS UN CHAMP CENTRIFUGE INTENSE; par T. SVEDBERG.

    E-print Network

    Paris-Sud XI, Université de

    LES MOLÉCULES DANS UN CHAMP CENTRIFUGE INTENSE; par T. SVEDBERG. Université d'Upsala (Suède). Sommaire. 2014 De l'étude du comportement des molécules dans des champs centrifuges intenses on peut tirer exposée. L'auteur décrit la réalisation des champs centrifuges allant jusqu'à 200 000 fois la pesanteur

  3. Scheduling on the MasPar SIMD parallel computer 

    E-print Network

    Perkins, Keith Douglas

    1995-01-01

    whose scheduling times are within 90% of optimal schedules 95% of the time. The highest level first algorithm was then modifies to handle the processor architecture on the Texas A&M University's MasPar parallel computer. These modifications included...

  4. Signaling crosstalk between TGF? and Dishevelled/Par1b.

    PubMed

    Mamidi, A; Inui, M; Manfrin, A; Soligo, S; Enzo, E; Aragona, M; Cordenonsi, M; Wessely, O; Dupont, S; Piccolo, S

    2012-10-01

    Crosstalk of signaling pathways is critical during metazoan development and adult tissue homeostasis. Even though the transforming growth factor-beta (TGF?) transduction cascade is rather simple, in vivo responsiveness to TGF? ligands is tightly regulated at several steps. As such, TGF? represents a paradigm for how the activity of one signaling system is modulated by others. Here, we report an unsuspected regulatory step involving Dishevelled (Dvl) and Par1b (also known as MARK2). Dvl and Par1b cooperate to enable TGF?/bone morphogenetic protein (BMP) signaling in Xenopus mesoderm development and TGF? responsiveness in mammalian cells. Mechanistically, the assembly of the Par1b/Dvl3/Smad4 complex is fostered by Wnt5a. The association of Smad4 to Dvl/Par1 prevents its inhibitory ubiquitination by ectodermin (also known as transcriptional intermediary factor 1 gamma or tripartite motif protein 33). We propose that this crosstalk is relevant to coordinate TGF? responses with Wnt-noncanonical and polarity pathways. PMID:22576663

  5. Filtrage par Noyaux de Convolution Iteratif Yuting Chen 1

    E-print Network

    Paris-Sud XI, Université de

    - ficult to apply. Nevertheless, Convolution Particle Filtering (CPF) was shown to be an efficient approach to all kinds of dynamic models, and appears robust. Keywords. Hidden Markov models, Nonlinear filters´ethode est par ailleurs g´en´erique, robuste et facilement adaptable. Mots-cl´es. Mod`ele de Markov cach

  6. INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE N attribu par la bibliothque

    E-print Network

    Paris-Sud XI, Université de

    , pour le suivi de mon travail, ses conseils au cours de ces trois années et ses suggestions pour'Antony, qui a encadré ce travail de recherche. Il a su par ses idées, ses conseils, ses explications et ses et de la clairvoyance de ses opinions. La confiance qu'il m'a accordée et son soutien constant ont

  7. The pars intermedia of the mink, Mustela vison

    Microsoft Academic Search

    B. Weman; A. Nobin

    1973-01-01

    The pars intermedia of intact and experimental female minks has been studied by light, electron and fluorescence microscopy. The general structure of the mink intermediate lobe is described. Two main cell types are recognized. One, termed glandular cell, predominates in number and is characterized by the presence of electron-dense granules about 200 nm in diameter and numerous large vesicles up

  8. Proposition de thse Contribution la modlisation physique du dosage par

    E-print Network

    Demouchy, Sylvie

    Proposition de thèse Contribution à la modélisation physique du dosage par microanalyse'étude proposée consiste à revoir les paramètres physiques fondamentaux intégrés dans les modèles analytiques et physique analytique mais son aboutissement est très appliqué car il permettra de quantifier avec précision

  9. Cheminement par trimestre -Baccalaurat en informatique La passerelle DEC SIM

    E-print Network

    Montréal, Université de

    Cheminement par trimestre - Baccalauréat en informatique La passerelle DEC SIM Le baccalauréat en informatique Le baccalauréat en informatique mise sur les aspects fondamentaux de l'informatique, favorisant l en mathématiques appliquées à l'informatique et à l'optimisation. On y aborde les problèmes pratiques

  10. Cheminement par trimestre --Mineure en informatique La mineure en informatique

    E-print Network

    Montréal, Université de

    Cheminement par trimestre -- Mineure en informatique La mineure en informatique La mineure est informatique. Ce programme est conçu pour être suivi concurremment avec une majeure ou d'autres mineures, et il cheminement d'une mineure en informatique peut être complété en 3 trimestres, avec des études à temps plein

  11. Cheminement par trimestre --Baccalaurat en informatique La passerelle DEC informatique

    E-print Network

    Montréal, Université de

    Cheminement par trimestre -- Baccalauréat en informatique La passerelle DEC informatique Le baccalauréat en informatique Le baccalauréat en informatique mise sur les aspects fondamentaux de l'informatique program- mation et en mathématiques appliquées à l'informatique et à l'optimisation. On y aborde les

  12. Cheminement par trimestre Le Baccalaurat en mathmatiques et informatique

    E-print Network

    Montréal, Université de

    Cheminement par trimestre Le Baccalauréat en mathématiques et informatique Le baccalauréat Le baccalauréat en mathématiques et informatique assure une formation solide en mathéma- tiques tout en permettant l'accès à un bon nombre de cours d'informatique offerts au pro- gramme. Plusieurs cours de

  13. Cheminement par trimestre --Majeure en informatique La majeure en informatique

    E-print Network

    Montréal, Université de

    Cheminement par trimestre -- Majeure en informatique La majeure en informatique La majeure est destinée à ceux qui désirent acquérir une formation en informatique ainsi qu'une for- mation de base dans une autre discipline. Elle permet l'accès à presque tous les cours d'informatique offerts au

  14. Acetylcholinesterase in der Pars distalis von Zonotrichia leucophrys gambelii (Aves)

    Microsoft Academic Search

    Eberhard Haase; Donald S. Farner

    1969-01-01

    Photoperiodic stimulation of photosensitive male white-crowned sparrows, Zonotrichia leucophrys gambelii, causes the appearance of acetylcholinesterase activity in the cephalic and caudal lobes of the pars distalis. In photosensitive birds held on short daily photoperiods little or no activity can he demonstrated histochemically. The enzyme is restricted to PAS-positive cells. After attaining a maximum between 31 and 52 days after the

  15. The Nucleus mesencephalicus lateralis, pars dorsalis in Neotropical Passerines

    Microsoft Academic Search

    Michael K. Rylander

    1979-01-01

    The volume of the nucleus mesencephalicus lateralis, pars dorsalis and the optic lobe were determined in 8 species of neotropical birds in the order Passeriformes: Pyrocephalus rubinus, Pitangus sulphuratus, Atticora fasciata, Molothrus bonariensis, Tangara nigrocincta, Ramphocelus dimidiatus, Euphonia xanthogaster and Spinus magellanicus. The ratio of the volume of the nucleus to the volume of the optic lobe was calculated for

  16. APPLICATION DES PALIERS A GAZ AUX GYROSCOPES Par G. GOBERT,

    E-print Network

    Paris-Sud XI, Université de

    43 APPLICATION DES PALIERS A GAZ AUX GYROSCOPES Par G. GOBERT, Centre d'Études Nucléaires de Saclay gyroscope dont le rotor de 4 cm de diamètre pesant plusieurs centaines de grammes tourne à une vitesse to the construction of a gyroscope. The rotor is 4 cm in diameter and runs at 180 000 r. p. m. Its weight is 500 g. LE

  17. Priorities for global felid conservation.

    PubMed

    Dickman, Amy J; Hinks, Amy E; Macdonald, Ewan A; Burnham, Dawn; Macdonald, David W

    2015-06-01

    Conservation resources are limited, necessitating prioritization of species and locations for action. Most prioritization approaches are based solely on biologically relevant characteristics of taxa or areas and ignore geopolitical realities. Doing so risks a poor return on conservation investment due to nonbiological factors, such as economic or political instability. We considered felids, a taxon which attracts intense conservation attention, to demonstrate a new approach that incorporates both intrinsic species traits and geopolitical characteristics of countries. We developed conservation priority scores for wild felids based on their International Union for Conservation of Nature status, body mass, habitat, range within protected area, evolutionary distinctiveness, and conservation umbrella potential. We used published data on governance, economics and welfare, human population pressures, and conservation policy to assign conservation-likelihood scores to 142 felid-hosting countries. We identified 71 countries as high priorities (above median) for felid conservation. These countries collectively encompassed all 36 felid species and supported an average of 96% of each species' range. Of these countries, 60.6% had below-average conservation-likelihood scores, which indicated these countries are relatively risky conservation investments. Governance was the most common factor limiting conservation likelihood. It was the major contributor to below-median likelihood scores for 62.5% of the 32 felid species occurring in lower-likelihood countries. Governance was followed by economics for which scores were below median for 25% of these species. An average of 58% of species' ranges occurred in 43 higher-priority lower-likelihood countries. Human population pressure was second to governance as a limiting factor when accounting for percentage of species' ranges in each country. As conservation likelihood decreases, it will be increasingly important to identify relevant geopolitical limitations and tailor conservation strategies accordingly. Our analysis provides an objective framework for biodiversity conservation action planning. Our results highlight not only which species most urgently require conservation action and which countries should be prioritized for such action, but also the diverse constraints which must be overcome to maximize long-term success. PMID:25864434

  18. National Conservation Training Center - USFWS

    Science.gov Websites

    Green Meetings Federally Approved Library Resources Conservation Library Digital Media Literature Search Publications Training Resources Training References Training Roadmaps...

  19. The influence of mixed-phase clouds on surface shortwave irradiance during the Arctic spring

    NASA Astrophysics Data System (ADS)

    Lubin, Dan; Vogelmann, Andrew M.

    2011-01-01

    The influence of mixed-phase stratiform clouds on the surface shortwave irradiance is examined using unique spectral shortwave irradiance measurements made during the Indirect and Semi-Direct Aerosol Campaign (ISDAC), supported by the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) program. An Analytical Spectral Devices (ASD, Inc.) spectroradiometer measured downwelling spectral irradiance from 350 to 2200 nm in one-minute averages throughout April-May 2008 from the ARM Climate Research Facility's North Slope of Alaska (NSA) site at Barrow. This study examines spectral irradiance measurements made under single-layer, overcast cloud decks having geometric thickness < 3000 m. Cloud optical depth is retrieved from irradiance in the interval 1022-1033 nm. The contrasting surface radiative influences of mixed-phase clouds and liquid-water clouds are discerned using irradiances in the 1.6-?m window. Compared with liquid-water clouds, mixed-phase clouds during the Arctic spring cause a greater reduction of shortwave irradiance at the surface. At fixed conservative-scattering optical depth (constant optical depth for wavelengths ? < 1100 nm), the presence of ice water in cloud reduces the near-IR surface irradiance by an additional several watts-per-meter-squared. This additional reduction, or supplemental ice absorption, is typically ˜5 W m-2 near solar noon over Barrow, and decreases with increasing solar zenith angle. However, for some cloud decks this additional absorption can be as large as 8-10 W m-2.

  20. UTILISATION MTABOLIQUE DES ACIDES GRAS DU TISSU ADIPEUX PAR LA POULE EN PONTE

    E-print Network

    Paris-Sud XI, Université de

    UTILISATION MÉTABOLIQUE DES ACIDES GRAS DU TISSU ADIPEUX PAR LA POULE EN PONTE B. LECLERCQ Marie . Le tissu adipeux de huit poules pondeuses est marqué par l'acide palmitique-1-14C. On suit pendant z8 contribution des réserves pour la vitellogenèse varie beaucoup d'une poule à l'autre et ne peut s'expliquer par

  1. ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The small serine resolvase ParA from bacterial plasmids RK2 and RP4 catalyzes the recombination of two identical 133 bp recombination sites known as MRS. Previously, we reported that ParA is active in the fission yeast Schizosaccharomyces pombe. In this work, the parA recombinase gene was placed un...

  2. Recherche d'images par rgions d'intrt : segmentation grossire rapide

    E-print Network

    Fauqueur, Julien

    approximative car elle prend en compte toutes les parties d'images, y compris celles qui ne sont pas pertinentesRecherche d'images par régions d'intérêt : segmentation grossière rapide et description couleur.Fauqueur,Nozha.Boujemaa}@inria.fr RÉSUMÉ. Les deux problèmes posés par un système de recherche d'images par régions sont la définition et

  3. A New Method for PAR Reduction of OFDM Signal Based on Chaotic Encoder

    Microsoft Academic Search

    Yong Guo; Liang Huang

    2010-01-01

    In this paper, we propose using chaotic digital filter to encode the time domain signal xn to reduce peak-to-average power ratio (PAR) in OFDM system. The xn may have high PAR value, which is a main drawback of OFDM system. The time domain signal becomes chaotically distributed by chaotic encoding, so the PAR value can be reduced. Simulations are done

  4. TRANSLATIONAL PHYSIOLOGY Discharge Rate of Substantia Nigra Pars Reticulata Neurons Is Reduced In

    E-print Network

    Friedman, Nir

    TRANSLATIONAL PHYSIOLOGY Discharge Rate of Substantia Nigra Pars Reticulata Neurons Is Reduced. Discharge rate of substantia nigra pars reticulata neurons is reduced in non-parkinsonian monkeys in the activity of the substantia nigra pars reticulata (SNr) of non-parkinsonian (normal) monkeys

  5. Article original Quantits d'herbe ingres par les vaches laitires, les

    E-print Network

    Boyer, Edmond

    Article original Quantités d'herbe ingérées par les vaches laitières, les génisses et les moutons d'herbe de référence (dans le système français des unités d'encombrement) ingérées par des bovins de type très différent et les liaisons entre les quantités d'herbe ingérées par des ovins et des bovins

  6. Production maximale de matire sche et rayon-nement solaire intercept par un couvert vgtal

    E-print Network

    Paris-Sud XI, Université de

    ., 1982...) et a particulièrement mis en évidence l'importance de l'interception du rayonnement solaire absorbée par le couvert végétal est calculée à partir de Fi et du rayonnement solaire global G (PAR, = 0Production maximale de matière sèche et rayon- nement solaire intercepté par un couvert végétal

  7. Energy Conservation Guidelines - 1: District Level Plan for Conservation.

    ERIC Educational Resources Information Center

    Peterson, Irving M., Ed.; Colavita, Leon J., Ed.

    Presented are suggestions written to help local school districts develop an energy conservation program in order to minimize budget problems brought about by rising energy costs. Program areas covered include formation of the district energy conservation team, assignment of duties, operation of energy audit systems, and evaluation procedures. To…

  8. Prophylactic neck irradiation

    SciTech Connect

    Rabuzzi, D.D.; Chung, C.T.; Sagerman, R.H.

    1980-08-01

    Treatment of subclinical cervical metastases from advanced squamous carcinomas of the nasopharynx, oropharynx, oral cavity, hypopharynx, and larynx remains contentious. Watchful waiting, elective neck surgery, and more recently, neck irradiation all have their advocates. The possibility of sterilization of the neck showing no clinical signs of metastasis has been especially appealing in concept. With this in mind, and by use of an external high-dose megavoltage technique, radiation therapy was used in 152 patients with clinically negative necks at the Upstate Medical Center from 1968 to 1977. Lymph node failures were extremely low (4%) when wide-field radiation ports were used and the primary lesion controlled.

  9. GAIA Forest Conservation Archives

    NSDL National Science Digital Library

    GAIA Forest Conservation Archives: For the past five years, Glen Barry, the Director of Ecological Enterprises, has been gathering and disseminating information concerning Papua New Guinea's rainforests, biodiversity and the indigenous environmental movement. This was done through Ecological Enterprises' "PNG Rainforest Campaign News" - an internet mailing list distributed to several hundred activists and academics worldwide. As the amount of information on the Internet about efforts by NGO and local peoples to protect rainforests and biodiversity greatly increased another mailing list was started, the "Worldwide Biodiversity/Forest Campaign News." Archives of these rainforest and biodiversity materials have been posted on this site along with recent articles, a selection of the best of the articles, government effects on rainforests, and more.

  10. National energy conservation

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A set of energy conservation actions that cut across all sectors of the economy were analyzed so that all actions under consideration be analyzed systematically and as a whole. The actions considered were as follows: (1) roll back the price of newly discovered oil, (2) freeze gasoline production for 3 years at 1972 levels, (3) mandate automobile mileage improvements, (4) require industry to improve energy efficiency, (5) require manufacture of household appliances with greater efficiency, (6) force conversion of many power plants from gas and oil to coal. The results showed that considerable gas and oil would be saved by forcing switches to coal. However, the large scale switch to coal was shown to require greatly increased outputs from many other industries that in turn require more energy. It was estimated that nearly 2.5 quads of additional coal were needed to produce these additional requirements. Also, the indirect requirements would create more jobs.

  11. Biodiversity and Conservation

    NSDL National Science Digital Library

    Bryant, Peter J.

    Peter J. Bryant, Professor of Developmental and Cell Biology at the University of California, Irvine, provides this hypertext book as a learning aid for his Biological Conservation class. It is an excellent, comprehensive introduction to the topic. Divided into sixteen understandable chapters, it covers such topics as the history of life, depletion and extinction from over-exploitation, exotic introductions, and deforestation, among others. The content is supported by illustrations, photos, charts, and a webliography for each chapter (a work in progress which is also available in full at the end of the book). However, the features that add the greatest value to the site are the well thought out hyperlinks to other relevant resources. There are literally hundreds of these; they combine with the original content of the site to form a powerful resource for undergraduate students.

  12. Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers’ experience

    Microsoft Academic Search

    Bruno Cutuli; Christine Cohen-Solal-le Nir; Brigitte de Lafontan; Hervé Mignotte; Virginie Fichet; Renaud Fay; Véronique Servent; Sylvia Giard; Claire Charra-Brunaud; Claire Lemanski; Hugues Auvray; Stéphane Jacquot; Jean-Christophe Charpentier

    2002-01-01

    Purpose: To assess the long-term outcome for women with ductal carcinoma in situ of the breast treated in current clinical practice by conservative surgery with or without definitive breast irradiation.Methods and Materials: We analyzed 705 cases of ductal carcinoma in situ treated between 1985 and 1995 in nine French regional cancer centers; 515 underwent conservative surgery and radiotherapy (CS+RT) and

  13. Modification of magnetic properties of epitaxial Co\\/Cu multilayers by 1 MeV C{sup +} irradiation

    Microsoft Academic Search

    M. C. Sung; D. G. You; H. S. Park; J. C. Lee; S. Y. Ie; I. S. Kim; C. N. Whang; S. Im; K. Jeong

    2001-01-01

    Epitaxial [Co\\/Cu]ââ grown on Si (001) has been irradiated by 1 MeV C{sup +} with a dose of 1 x 10¹⁶\\/cm². The intrinsic characteristics of epitaxy, such as crystal structure and fourfold magnetic anisotropy, are conserved after ion irradiation. However, the extrinsic magnetic properties are changed such that the coercivity decreases and the squareness of the hysteresis loop is noticeably

  14. Quantitative CW Nd:YAG pars plana transscleral photocoagulation in postmortem eyes

    SciTech Connect

    Schubert, H.D.; Agarwala, A. (Retina Service and Research Division, Wills Eye Hospital, Philadelphia, PA (USA))

    1990-12-01

    The effect of different types of burns and numbers of lesions on, and the role of initial pressure head in, the rate of aqueous outflow was studied in enucleated human and porcine eyes. Noncontact and contact CW Nd:YAG laser applied to human eyes 3 mm posterior to the limbus produced a 34% and 51% increase, respectively, in outflow as compared with controls (P = .01). In porcine eyes, outflow increased directly with the number of noncontact burns as well as with the amount of perfusion pressure. Our results suggest that intraocular pressure and outflow are functions of both the intensity of irradiation and the surface area treated, and that each individual pressure head may require an optimal pars plana area of treatment of therapeutic degree to lower pressure and yet prevent overfiltration and phthisis. Our results also suggest that there may be a passive transneuroepithelial and transscleral outflow component in clinical laser cycloablation and, therefore, a need to grade laser treatments in order to prevent visual loss through unnecessary injury.

  15. Etudes par spectroscopie Raman et par RMN des verres du système B2O3SiO2Li2O

    Microsoft Academic Search

    Jean-Claude Brethous; Alain Levasseur; Gerard Villeneuve; Patrick Echegut; Paul Hagenmuller; Michel Couzi

    1981-01-01

    Une approche structurale par spectroscopie Raman des verres du système B2O3-SiO2-Li2O a été effectuée. D'autre part une étude de l'environment du bore par RMN a été entreprise. Les résultats obtenus semblent indiquer que ces verres sont constitués de deux phases vitreuses distinctes, respectivement boratée et silicatée. Des phénomènes de démixtion ont d'ailleurs été mis en évidence par microscopie électronique à

  16. PRODUCTION DE TRITIUM DANS LE THORIUM PAR DES PROTONS DE 135 MeV Par M. LEFORT, G. SIMONOFF et X. TARRAGO

    E-print Network

    Paris-Sud XI, Université de

    959 PRODUCTION DE TRITIUM DANS LE THORIUM PAR DES PROTONS DE 135 MeV Par M. LEFORT, G. SIMONOFF et Saclay. Résumé. 2014 On a mesuré la section efficace de production de tritium après bombardment de thorium par des protons de 135 MeV accélérés au synchro-cyclotron d'Orsay. Le tritium était extrait des

  17. Binding and Spreading of ParB on DNA Determine Its Biological Function in Pseudomonas aeruginosa?†

    PubMed Central

    Kusiak, Magdalena; Gapczy?ska, Anna; P?ochocka, Danuta; Thomas, Christopher M.; Jagura-Burdzy, Gra?yna

    2011-01-01

    ParB protein of Pseudomonas aeruginosa belongs to a widely represented ParB family of chromosomally and plasmid-encoded partitioning type IA proteins. Ten putative parS sites are dispersed in the P. aeruginosa chromosome, with eight of them localizing in the oriC domain. After binding to parS, ParB spreads on the DNA, causing transcriptional silencing of nearby genes (A. A. Bartosik et al., J. Bacteriol. 186:6983–6998, 2004). We have studied ParB derivatives impaired in spreading either due to loss of DNA-binding ability or oligomerization. We defined specific determinants outside of the helix-turn-helix motif responsible for DNA binding. Analysis confirmed the localization of the main dimerization domain in the C terminus of ParB but also mapped another self-interactive domain in the N-terminal domain. Reverse genetics were used to introduce five parB alleles impaired in spreading into the P. aeruginosa chromosome. The single amino acid substitutions in ParB causing a defect in oligomerization but not in DNA binding caused a chromosome segregation defect, slowed the growth rate, and impaired motilities, similarly to the pleiotropic phenotype of parB-null mutants, indicating that the ability to spread is vital for ParB function in the cell. The toxicity of ParB overproduction in Pseudomonas spp. is not due to the spreading since several ParB derivatives defective in oligomerization were still toxic for P. aeruginosa when provided in excess. PMID:21531806

  18. Cost of Conservation of Agrobiodiversity

    Microsoft Academic Search

    Anil K. Gupta; Saxena Sanjeev; Chandak Vikas; Gosh Shrabani B; Sinha Riya; Jain Neeru

    The cost of conservation of germplasm stored in gene banks i.e., ex-situ collections has been studied in other parts of the world to estimate direct and indirect contributions by various actors involved in conservation. This is the first study of its kind in India done in collaboration with National Bureau of Plant Genetic Resources, New Delhi. This was part of

  19. Conservation Biology Navjot S. Sodhi

    E-print Network

    Wisenden, Brian D.

    while the book was prepared) Paul R. Ehrlich Department of Biology, Stanford University 1 1 © Oxford Introduction Navjot S. Sodhi and Paul R. Ehrlich 1 Introduction Box 1: Human population and conservation (Paul R. Ehrlich) 2 Introduction Box 2: Ecoethics (Paul R. Ehrlich) 3 1: Conservation biology: past

  20. Conservation Area Networks Sahotra Sarkar

    E-print Network

    Sarkar, Sahotra

    assumption: that the appropriate spatial units of conservation interest were reserves such as national parks. As Indias Project Tiger demonstrated, lack of local support is a recipe for disaster for conservation that many types of human activity, for instance, the conversion of natural habitat to industrial parks