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Sample records for continuation-based global optimization

  1. Software for global optimization

    SciTech Connect

    Mockus, L.

    1994-12-31

    The interactive graphical software that implements numeric methods and other techniques to solve global optimization problems is presented. The Bayesian approach to the optimization is the underlying idea of numeric methods used. Software is designed to solve deterministic and stochastic problems of different complexity and with many variables. It includes global and local optimization methods for differentiable and nondifferentiable functions. Implemented numerical techniques for global optimization vary from simple Monte-Carlo simulation to Bayesian methods by J. Mockus and extrapolation theory based methods by Zilinskas. Local optimization techniques includes simplex method of Nelder and Mead method of nonlinear programming by Shitkowski, and method of stochastic approximation with Bayesian step size control by J. Mockus. Software is interactive, it allows user to start and stop chosen method of global or local optimization, define and change its parameters and examine the solution process. Out-put from solution process is both numerical and graphical. Currently available graphical features are the projection of the objective function on a chosen plane and convergence plot. Both these features let the user easily observe solution process and interactively modify it. More features can be added in a standard way. It is up to the user how many graphical and numerical output features activate or deactivate at any given time. Software is implemented in C++ using X Windows as graphical platform.

  2. Homotopy optimization methods for global optimization.

    SciTech Connect

    Dunlavy, Daniel M.; O'Leary, Dianne P.

    2005-12-01

    We define a new method for global optimization, the Homotopy Optimization Method (HOM). This method differs from previous homotopy and continuation methods in that its aim is to find a minimizer for each of a set of values of the homotopy parameter, rather than to follow a path of minimizers. We define a second method, called HOPE, by allowing HOM to follow an ensemble of points obtained by perturbation of previous ones. We relate this new method to standard methods such as simulated annealing and show under what circumstances it is superior. We present results of extensive numerical experiments demonstrating performance of HOM and HOPE.

  3. Enhancing Polyhedral Relaxations for Global Optimization

    ERIC Educational Resources Information Center

    Bao, Xiaowei

    2009-01-01

    During the last decade, global optimization has attracted a lot of attention due to the increased practical need for obtaining global solutions and the success in solving many global optimization problems that were previously considered intractable. In general, the central question of global optimization is to find an optimal solution to a given…

  4. Global optimality of extremals: An example

    NASA Technical Reports Server (NTRS)

    Kreindler, E.; Newman, F.

    1980-01-01

    The question of the existence and location of Darboux points is crucial for minimally sufficient conditions for global optimality and for computation of optimal trajectories. A numerical investigation is presented of the Darboux points and their relationship with conjugate points for a problem of minimum fuel, constant velocity, and horizontal aircraft turns to capture a line. This simple second order optimal control problem shows that ignoring the possible existence of Darboux points may play havoc with the computation of optimal trajectories.

  5. Bayesian approach to global discrete optimization

    SciTech Connect

    Mockus, J.; Mockus, A.; Mockus, L.

    1994-12-31

    We discuss advantages and disadvantages of the Bayesian approach (average case analysis). We present the portable interactive version of software for continuous global optimization. We consider practical multidimensional problems of continuous global optimization, such as optimization of VLSI yield, optimization of composite laminates, estimation of unknown parameters of bilinear time series. We extend Bayesian approach to discrete optimization. We regard the discrete optimization as a multi-stage decision problem. We assume that there exists some simple heuristic function which roughly predicts the consequences of the decisions. We suppose randomized decisions. We define the probability of the decision by the randomized decision function depending on heuristics. We fix this function with exception of some parameters. We repeat the randomized decision several times at the fixed values of those parameters and accept the best decision as the result. We optimize the parameters of the randomized decision function to make the search more efficient. Thus we reduce the discrete optimization problem to the continuous problem of global stochastic optimization. We solve this problem by the Bayesian methods of continuous global optimization. We describe the applications to some well known An problems of discrete programming, such as knapsack, traveling salesman, and scheduling.

  6. Global and Local Optimization Algorithms for Optimal Signal Set Design

    PubMed Central

    Kearsley, Anthony J.

    2001-01-01

    The problem of choosing an optimal signal set for non-Gaussian detection was reduced to a smooth inequality constrained mini-max nonlinear programming problem by Gockenbach and Kearsley. Here we consider the application of several optimization algorithms, both global and local, to this problem. The most promising results are obtained when special-purpose sequential quadratic programming (SQP) algorithms are embedded into stochastic global algorithms.

  7. Intervals in evolutionary algorithms for global optimization

    SciTech Connect

    Patil, R.B.

    1995-05-01

    Optimization is of central concern to a number of disciplines. Interval Arithmetic methods for global optimization provide us with (guaranteed) verified results. These methods are mainly restricted to the classes of objective functions that are twice differentiable and use a simple strategy of eliminating a splitting larger regions of search space in the global optimization process. An efficient approach that combines the efficient strategy from Interval Global Optimization Methods and robustness of the Evolutionary Algorithms is proposed. In the proposed approach, search begins with randomly created interval vectors with interval widths equal to the whole domain. Before the beginning of the evolutionary process, fitness of these interval parameter vectors is defined by evaluating the objective function at the center of the initial interval vectors. In the subsequent evolutionary process the local optimization process returns an estimate of the bounds of the objective function over the interval vectors. Though these bounds may not be correct at the beginning due to large interval widths and complicated function properties, the process of reducing interval widths over time and a selection approach similar to simulated annealing helps in estimating reasonably correct bounds as the population evolves. The interval parameter vectors at these estimated bounds (local optima) are then subjected to crossover and mutation operators. This evolutionary process continues for predetermined number of generations in the search of the global optimum.

  8. Global Design Optimization for Fluid Machinery Applications

    NASA Technical Reports Server (NTRS)

    Shyy, Wei; Papila, Nilay; Tucker, Kevin; Vaidyanathan, Raj; Griffin, Lisa

    2000-01-01

    Recent experiences in utilizing the global optimization methodology, based on polynomial and neural network techniques for fluid machinery design are summarized. Global optimization methods can utilize the information collected from various sources and by different tools. These methods offer multi-criterion optimization, handle the existence of multiple design points and trade-offs via insight into the entire design space can easily perform tasks in parallel, and are often effective in filtering the noise intrinsic to numerical and experimental data. Another advantage is that these methods do not need to calculate the sensitivity of each design variable locally. However, a successful application of the global optimization method needs to address issues related to data requirements with an increase in the number of design variables and methods for predicting the model performance. Examples of applications selected from rocket propulsion components including a supersonic turbine and an injector element and a turbulent flow diffuser are used to illustrate the usefulness of the global optimization method.

  9. Global optimization methods for engineering design

    NASA Technical Reports Server (NTRS)

    Arora, Jasbir S.

    1990-01-01

    The problem is to find a global minimum for the Problem P. Necessary and sufficient conditions are available for local optimality. However, global solution can be assured only under the assumption of convexity of the problem. If the constraint set S is compact and the cost function is continuous on it, existence of a global minimum is guaranteed. However, in view of the fact that no global optimality conditions are available, a global solution can be found only by an exhaustive search to satisfy Inequality. The exhaustive search can be organized in such a way that the entire design space need not be searched for the solution. This way the computational burden is reduced somewhat. It is concluded that zooming algorithm for global optimizations appears to be a good alternative to stochastic methods. More testing is needed; a general, robust, and efficient local minimizer is required. IDESIGN was used in all numerical calculations which is based on a sequential quadratic programming algorithm, and since feasible set keeps on shrinking, a good algorithm to find an initial feasible point is required. Such algorithms need to be developed and evaluated.

  10. Global source optimization for MEEF and OPE

    NASA Astrophysics Data System (ADS)

    Matsui, Ryota; Noda, Tomoya; Aoyama, Hajime; Kita, Naonori; Matsuyama, Tomoyuki; Flagello, Donis

    2013-04-01

    This work describes freeform source optimization considering mask error enhancement factor (MEEF), optical proximity effect (OPE), process window, and hardware-specific constraints. Our algorithm allows users to define maximum allowed MEEF and OPE error as constraints without defining weights among the metrics. We also consider hardware specific constraints, so that the optimized source is suitable to be realized in Nikon's Intelligent Illumination hardware. Our approach utilizes a global optimization procedure to arrive at a freeform source shape solution, and since each source grid-point is assigned as variable, the source solution encompasses the maximum amount of degrees of freedom.

  11. Electronic neural networks for global optimization

    NASA Technical Reports Server (NTRS)

    Thakoor, A. P.; Moopenn, A. W.; Eberhardt, S.

    1990-01-01

    An electronic neural network with feedback architecture, implemented in analog custom VLSI is described. Its application to problems of global optimization for dynamic assignment is discussed. The convergence properties of the neural network hardware are compared with computer simulation results. The neural network's ability to provide optimal or near optimal solutions within only a few neuron time constants, a speed enhancement of several orders of magnitude over conventional search methods, is demonstrated. The effect of noise on the circuit dynamics and the convergence behavior of the neural network hardware is also examined.

  12. Global Optimality of the Successive Maxbet Algorithm.

    ERIC Educational Resources Information Center

    Hanafi, Mohamed; ten Berge, Jos M. F.

    2003-01-01

    It is known that the Maxbet algorithm, which is an alternative to the method of generalized canonical correlation analysis and Procrustes analysis, may converge to local maxima. Discusses an eigenvalue criterion that is sufficient, but not necessary, for global optimality of the successive Maxbet algorithm. (SLD)

  13. A Novel Particle Swarm Optimization Algorithm for Global Optimization

    PubMed Central

    Wang, Chun-Feng; Liu, Kui

    2016-01-01

    Particle Swarm Optimization (PSO) is a recently developed optimization method, which has attracted interest of researchers in various areas due to its simplicity and effectiveness, and many variants have been proposed. In this paper, a novel Particle Swarm Optimization algorithm is presented, in which the information of the best neighbor of each particle and the best particle of the entire population in the current iteration is considered. Meanwhile, to avoid premature, an abandoned mechanism is used. Furthermore, for improving the global convergence speed of our algorithm, a chaotic search is adopted in the best solution of the current iteration. To verify the performance of our algorithm, standard test functions have been employed. The experimental results show that the algorithm is much more robust and efficient than some existing Particle Swarm Optimization algorithms. PMID:26955387

  14. A Novel Particle Swarm Optimization Algorithm for Global Optimization.

    PubMed

    Wang, Chun-Feng; Liu, Kui

    2016-01-01

    Particle Swarm Optimization (PSO) is a recently developed optimization method, which has attracted interest of researchers in various areas due to its simplicity and effectiveness, and many variants have been proposed. In this paper, a novel Particle Swarm Optimization algorithm is presented, in which the information of the best neighbor of each particle and the best particle of the entire population in the current iteration is considered. Meanwhile, to avoid premature, an abandoned mechanism is used. Furthermore, for improving the global convergence speed of our algorithm, a chaotic search is adopted in the best solution of the current iteration. To verify the performance of our algorithm, standard test functions have been employed. The experimental results show that the algorithm is much more robust and efficient than some existing Particle Swarm Optimization algorithms. PMID:26955387

  15. Global optimization algorithm for heat exchanger networks

    SciTech Connect

    Quesada, I.; Grossmann, I.E. )

    1993-03-01

    This paper deals with the global optimization of heat exchanger networks with fixed topology. It is shown that if linear area cost functions are assumed, as well as arithmetic mean driving force temperature differences in networks with isothermal mixing, the corresponding nonlinear programming (NLP) optimization problem involves linear constraints and a sum of linear fractional functions in the objective which are nonconvex. A rigorous algorithm is proposed that is based on a convex NLP underestimator that involves linear and nonlinear estimators for fractional and bilinear terms which provide a tight lower bound to the global optimum. This NLP problem is used within a spatial branch and bound method for which branching rules are given. Basic properties of the proposed method are presented, and its application is illustrated with several example problems. The results show that the proposed method only requires few nodes in the branch and bound search.

  16. Global optimization of bilinear engineering design models

    SciTech Connect

    Grossmann, I.; Quesada, I.

    1994-12-31

    Recently Quesada and Grossmann have proposed a global optimization algorithm for solving NLP problems involving linear fractional and bilinear terms. This model has been motivated by a number of applications in process design. The proposed method relies on the derivation of a convex NLP underestimator problem that is used within a spatial branch and bound search. This paper explores the use of alternative bounding approximations for constructing the underestimator problem. These are applied in the global optimization of problems arising in different engineering areas and for which different relaxations are proposed depending on the mathematical structure of the models. These relaxations include linear and nonlinear underestimator problems. Reformulations that generate additional estimator functions are also employed. Examples from process design, structural design, portfolio investment and layout design are presented.

  17. Competing intelligent search agents in global optimization

    SciTech Connect

    Streltsov, S.; Vakili, P.; Muchnik, I.

    1996-12-31

    In this paper we present a new search methodology that we view as a development of intelligent agent approach to the analysis of complex system. The main idea is to consider search process as a competition mechanism between concurrent adaptive intelligent agents. Agents cooperate in achieving a common search goal and at the same time compete with each other for computational resources. We propose a statistical selection approach to resource allocation between agents that leads to simple and efficient on average index allocation policies. We use global optimization as the most general setting that encompasses many types of search problems, and show how proposed selection policies can be used to improve and combine various global optimization methods.

  18. Solving global optimization problems on GPU cluster

    NASA Astrophysics Data System (ADS)

    Barkalov, Konstantin; Gergel, Victor; Lebedev, Ilya

    2016-06-01

    The paper contains the results of investigation of a parallel global optimization algorithm combined with a dimension reduction scheme. This allows solving multidimensional problems by means of reducing to data-independent subproblems with smaller dimension solved in parallel. The new element implemented in the research consists in using several graphic accelerators at different computing nodes. The paper also includes results of solving problems of well-known multiextremal test class GKLS on Lobachevsky supercomputer using tens of thousands of GPU cores.

  19. Global optimization of actively morphing flapping wings

    NASA Astrophysics Data System (ADS)

    Ghommem, Mehdi; Hajj, Muhammad R.; Mook, Dean T.; Stanford, Bret K.; Beran, Philip S.; Snyder, Richard D.; Watson, Layne T.

    2012-08-01

    We consider active shape morphing to optimize the flight performance of flapping wings. To this end, we combine a three-dimensional version of the unsteady vortex lattice method (UVLM) with a deterministic global optimization algorithm to identify the optimal kinematics that maximize the propulsive efficiency under lift and thrust constraints. The UVLM applies only to incompressible, inviscid flows where the separation lines are known a priori. Two types of morphing parameterization are investigated here—trigonometric and spline-based. The results show that the spline-based morphing, which requires specification of more design variables, yields a significant improvement in terms of propulsive efficiency. Furthermore, we remark that the average value of the lift coefficient in the optimized kinematics remained equal to the value in the baseline case (without morphing). This indicates that morphing is most efficiently used to generate thrust and not to increase lift beyond the basic value obtained by flapping only. Besides, our study gives comparable optimal efficiencies to those obtained from previous studies based on gradient-based optimization, but completely different design points (especially for the spline-based morphing), which would indicate that the design space associated with the flapping kinematics is very complex.

  20. On Global Optimal Sailplane Flight Strategy

    NASA Technical Reports Server (NTRS)

    Sander, G. J.; Litt, F. X.

    1979-01-01

    The derivation and interpretation of the necessary conditions that a sailplane cross-country flight has to satisfy to achieve the maximum global flight speed is considered. Simple rules are obtained for two specific meteorological models. The first one uses concentrated lifts of various strengths and unequal distance. The second one takes into account finite, nonuniform space amplitudes for the lifts and allows, therefore, for dolphin style flight. In both models, altitude constraints consisting of upper and lower limits are shown to be essential to model realistic problems. Numerical examples illustrate the difference with existing techniques based on local optimality conditions.

  1. LDRD Final Report: Global Optimization for Engineering Science Problems

    SciTech Connect

    HART,WILLIAM E.

    1999-12-01

    For a wide variety of scientific and engineering problems the desired solution corresponds to an optimal set of objective function parameters, where the objective function measures a solution's quality. The main goal of the LDRD ''Global Optimization for Engineering Science Problems'' was the development of new robust and efficient optimization algorithms that can be used to find globally optimal solutions to complex optimization problems. This SAND report summarizes the technical accomplishments of this LDRD, discusses lessons learned and describes open research issues.

  2. Global Optimization Techniques for Fluid Flow and Propulsion Devices

    NASA Technical Reports Server (NTRS)

    Shyy, Wei; Papila, Nilay; Vaidyanathan, Raj; Tucker, Kevin; Griffin, Lisa; Dorney, Dan; Huber, Frank; Tran, Ken; Turner, James E. (Technical Monitor)

    2001-01-01

    This viewgraph presentation gives an overview of global optimization techniques for fluid flow and propulsion devices. Details are given on the need, characteristics, and techniques for global optimization. The techniques include response surface methodology (RSM), neural networks and back-propagation neural networks, design of experiments, face centered composite design (FCCD), orthogonal arrays, outlier analysis, and design optimization.

  3. An approximation based global optimization strategy for structural synthesis

    NASA Technical Reports Server (NTRS)

    Sepulveda, A. E.; Schmit, L. A.

    1991-01-01

    A global optimization strategy for structural synthesis based on approximation concepts is presented. The methodology involves the solution of a sequence of highly accurate approximate problems using a global optimization algorithm. The global optimization algorithm implemented consists of a branch and bound strategy based on the interval evaluation of the objective function and constraint functions, combined with a local feasible directions algorithm. The approximate design optimization problems are constructed using first order approximations of selected intermediate response quantities in terms of intermediate design variables. Some numerical results for example problems are presented to illustrate the efficacy of the design procedure setforth.

  4. Global smoothing and continuation for large-scale molecular optimization

    SciTech Connect

    More, J.J.; Wu, Zhijun

    1995-10-01

    We discuss the formulation of optimization problems that arise in the study of distance geometry, ionic systems, and molecular clusters. We show that continuation techniques based on global smoothing are applicable to these molecular optimization problems, and we outline the issues that must be resolved in the solution of large-scale molecular optimization problems.

  5. Strategies for Global Optimization of Temporal Preferences

    NASA Technical Reports Server (NTRS)

    Morris, Paul; Morris, Robert; Khatib, Lina; Ramakrishnan, Sailesh

    2004-01-01

    A temporal reasoning problem can often be naturally characterized as a collection of constraints with associated local preferences for times that make up the admissible values for those constraints. Globally preferred solutions to such problems emerge as a result of well-defined operations that compose and order temporal assignments. The overall objective of this work is a characterization of different notions of global preference, and to identify tractable sub-classes of temporal reasoning problems incorporating these notions. This paper extends previous results by refining the class of useful notions of global temporal preference that are associated with problems that admit of tractable solution techniques. This paper also answers the hitherto open question of whether problems that seek solutions that are globally preferred from a Utilitarian criterion for global preference can be found tractably.

  6. Applications of parallel global optimization to mechanics problems

    NASA Astrophysics Data System (ADS)

    Schutte, Jaco Francois

    Global optimization of complex engineering problems, with a high number of variables and local minima, requires sophisticated algorithms with global search capabilities and high computational efficiency. With the growing availability of parallel processing, it makes sense to address these requirements by increasing the parallelism in optimization strategies. This study proposes three methods of concurrent processing. The first method entails exploiting the structure of population-based global algorithms such as the stochastic Particle Swarm Optimization (PSO) algorithm and the Genetic Algorithm (GA). As a demonstration of how such an algorithm may be adapted for concurrent processing we modify and apply the PSO to several mechanical optimization problems on a parallel processing machine. Desirable PSO algorithm features such as insensitivity to design variable scaling and modest sensitivity to algorithm parameters are demonstrated. A second approach to parallelism and improving algorithm efficiency is by utilizing multiple optimizations. With this method a budget of fitness evaluations is distributed among several independent sub-optimizations in place of a single extended optimization. Under certain conditions this strategy obtains a higher combined probability of converging to the global optimum than a single optimization which utilizes the full budget of fitness evaluations. The third and final method of parallelism addressed in this study is the use of quasiseparable decomposition, which is applied to decompose loosely coupled problems. This yields several sub-problems of lesser dimensionality which may be concurrently optimized with reduced effort.

  7. Modeling and Global Optimization of DNA separation

    PubMed Central

    Fahrenkopf, Max A.; Ydstie, B. Erik; Mukherjee, Tamal; Schneider, James W.

    2014-01-01

    We develop a non-convex non-linear programming problem that determines the minimum run time to resolve different lengths of DNA using a gel-free micelle end-labeled free solution electrophoresis separation method. Our optimization framework allows for efficient determination of the utility of different DNA separation platforms and enables the identification of the optimal operating conditions for these DNA separation devices. The non-linear programming problem requires a model for signal spacing and signal width, which is known for many DNA separation methods. As a case study, we show how our approach is used to determine the optimal run conditions for micelle end-labeled free-solution electrophoresis and examine the trade-offs between a single capillary system and a parallel capillary system. Parallel capillaries are shown to only be beneficial for DNA lengths above 230 bases using a polydisperse micelle end-label otherwise single capillaries produce faster separations. PMID:24764606

  8. Modeling and Global Optimization of DNA separation.

    PubMed

    Fahrenkopf, Max A; Ydstie, B Erik; Mukherjee, Tamal; Schneider, James W

    2014-05-01

    We develop a non-convex non-linear programming problem that determines the minimum run time to resolve different lengths of DNA using a gel-free micelle end-labeled free solution electrophoresis separation method. Our optimization framework allows for efficient determination of the utility of different DNA separation platforms and enables the identification of the optimal operating conditions for these DNA separation devices. The non-linear programming problem requires a model for signal spacing and signal width, which is known for many DNA separation methods. As a case study, we show how our approach is used to determine the optimal run conditions for micelle end-labeled free-solution electrophoresis and examine the trade-offs between a single capillary system and a parallel capillary system. Parallel capillaries are shown to only be beneficial for DNA lengths above 230 bases using a polydisperse micelle end-label otherwise single capillaries produce faster separations. PMID:24764606

  9. Global search algorithm for optimal control

    NASA Technical Reports Server (NTRS)

    Brocker, D. H.; Kavanaugh, W. P.; Stewart, E. C.

    1970-01-01

    Random-search algorithm employs local and global properties to solve two-point boundary value problem in Pontryagin maximum principle for either fixed or variable end-time problems. Mixed boundary value problem is transformed to an initial value problem. Mapping between initial and terminal values utilizes hybrid computer.

  10. Globally optimal trial design for local decision making.

    PubMed

    Eckermann, Simon; Willan, Andrew R

    2009-02-01

    Value of information methods allows decision makers to identify efficient trial design following a principle of maximizing the expected value to decision makers of information from potential trial designs relative to their expected cost. However, in health technology assessment (HTA) the restrictive assumption has been made that, prospectively, there is only expected value of sample information from research commissioned within jurisdiction. This paper extends the framework for optimal trial design and decision making within jurisdiction to allow for optimal trial design across jurisdictions. This is illustrated in identifying an optimal trial design for decision making across the US, the UK and Australia for early versus late external cephalic version for pregnant women presenting in the breech position. The expected net gain from locally optimal trial designs of US$0.72M is shown to increase to US$1.14M with a globally optimal trial design. In general, the proposed method of globally optimal trial design improves on optimal trial design within jurisdictions by: (i) reflecting the global value of non-rival information; (ii) allowing optimal allocation of trial sample across jurisdictions; (iii) avoiding market failure associated with free-rider effects, sub-optimal spreading of fixed costs and heterogeneity of trial information with multiple trials. PMID:18435429

  11. Nonlinear Global Optimization Using Curdling Algorithm

    Energy Science and Technology Software Center (ESTSC)

    1996-03-01

    An algorithm for performing curdling optimization which is a derivative-free, grid-refinement approach to nonlinear optimization was developed and implemented in software. This approach overcomes a number of deficiencies in existing approaches. Most notably, it finds extremal regions rather than only single external extremal points. The program is interactive and collects information on control parameters and constraints using menus. For up to four dimensions, function convergence is displayed graphically. Because the algorithm does not compute derivatives,more » gradients or vectors, it is numerically stable. It can find all the roots of a polynomial in one pass. It is an inherently parallel algorithm. Constraints are handled as being initially fuzzy, but become tighter with each iteration.« less

  12. Neural network training with global optimization techniques.

    PubMed

    Yamazaki, Akio; Ludermir, Teresa B

    2003-04-01

    This paper presents an approach of using Simulated Annealing and Tabu Search for the simultaneous optimization of neural network architectures and weights. The problem considered is the odor recognition in an artificial nose. Both methods have produced networks with high classification performance and low complexity. Generalization has been improved by using the backpropagation algorithm for fine tuning. The combination of simple and traditional search methods has shown to be very suitable for generating compact and efficient networks. PMID:12923920

  13. Dispositional optimism and terminal decline in global quality of life.

    PubMed

    Zaslavsky, Oleg; Palgi, Yuval; Rillamas-Sun, Eileen; LaCroix, Andrea Z; Schnall, Eliezer; Woods, Nancy F; Cochrane, Barbara B; Garcia, Lorena; Hingle, Melanie; Post, Stephen; Seguin, Rebecca; Tindle, Hilary; Shrira, Amit

    2015-06-01

    We examined whether dispositional optimism relates to change in global quality of life (QOL) as a function of either chronological age or years to impending death. We used a sample of 2,096 deceased postmenopausal women from the Women's Health Initiative clinical trials who were enrolled in the 2005-2010 Extension Study and for whom at least 1 global QOL and optimism measure were analyzed. Growth curve models were examined. Competing models were contrasted using model fit criteria. On average, levels of global QOL decreased with both higher age and closer proximity to death (e.g., M(score) = 7.7 eight years prior to death vs. M(score) = 6.1 one year prior to death). A decline in global QOL was better modeled as a function of distance to death (DtD) than as a function of chronological age (Bayesian information criterion [BIC](DtD) = 22,964.8 vs. BIC(age) = 23,322.6). Optimism was a significant correlate of both linear (estimate(DtD) = -0.01, SE(DtD) = 0.005; ρ = 0.004) and quadratic (estimate(DtD) = -0.006, SE(DtD) = 0.002; ρ = 0.004) terminal decline in global QOL so that death-related decline in global QOL was steeper among those with a high level of optimism than those with a low level of optimism. We found that dispositional optimism helps to maintain positive psychological perspective in the face of age-related decline. Optimists maintain higher QOL compared with pessimists when death-related trajectories were considered; however, the gap between those with high optimism and those with low optimism progressively attenuated with closer proximity to death, to the point that is became nonsignificant at the time of death. PMID:25938553

  14. Optimizing human activity patterns using global sensitivity analysis

    PubMed Central

    Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2014-01-01

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. We use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations. PMID:25580080

  15. Optimizing human activity patterns using global sensitivity analysis

    SciTech Connect

    Fairchild, Geoffrey; Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2013-12-10

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. Here we use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Finally, though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.

  16. Global optimization of multicomponent distillation configurations: 2. Enumeration based global minimization algorithm

    DOE PAGESBeta

    Nallasivam, Ulaganathan; Shah, Vishesh H.; Shenvi, Anirudh A.; Huff, Joshua; Tawarmalani, Mohit; Agrawal, Rakesh

    2016-02-10

    We present a general Global Minimization Algorithm (GMA) to identify basic or thermally coupled distillation configurations that require the least vapor duty under minimum reflux conditions for separating any ideal or near-ideal multicomponent mixture into a desired number of product streams. In this algorithm, global optimality is guaranteed by modeling the system using Underwood equations and reformulating the resulting constraints to bilinear inequalities. The speed of convergence to the globally optimal solution is increased by using appropriate feasibility and optimality based variable-range reduction techniques and by developing valid inequalities. As a result, the GMA can be coupled with already developedmore » techniques that enumerate basic and thermally coupled distillation configurations, to provide for the first time, a global optimization based rank-list of distillation configurations.« less

  17. Communication: Optimal parameters for basin-hopping global optimization based on Tsallis statistics

    SciTech Connect

    Shang, C. Wales, D. J.

    2014-08-21

    A fundamental problem associated with global optimization is the large free energy barrier for the corresponding solid-solid phase transitions for systems with multi-funnel energy landscapes. To address this issue we consider the Tsallis weight instead of the Boltzmann weight to define the acceptance ratio for basin-hopping global optimization. Benchmarks for atomic clusters show that using the optimal Tsallis weight can improve the efficiency by roughly a factor of two. We present a theory that connects the optimal parameters for the Tsallis weighting, and demonstrate that the predictions are verified for each of the test cases.

  18. Similarity-based global optimization of buildings in urban scene

    NASA Astrophysics Data System (ADS)

    Zhu, Quansheng; Zhang, Jing; Jiang, Wanshou

    2013-10-01

    In this paper, an approach for the similarity-based global optimization of buildings in urban scene is presented. In the past, most researches concentrated on single building reconstruction, making it difficult to reconstruct reliable models from noisy or incomplete point clouds. To obtain a better result, a new trend is to utilize the similarity among the buildings. Therefore, a new similarity detection and global optimization strategy is adopted to modify local-fitting geometric errors. Firstly, the hierarchical structure that consists of geometric, topological and semantic features is constructed to represent complex roof models. Secondly, similar roof models can be detected by combining primitive structure and connection similarities. At last, the global optimization strategy is applied to preserve the consistency and precision of similar roof structures. Moreover, non-local consolidation is adapted to detect small roof parts. The experiments reveal that the proposed method can obtain convincing roof models and promote the reconstruction quality of 3D buildings in urban scene.

  19. Global search acceleration in the nested optimization scheme

    NASA Astrophysics Data System (ADS)

    Grishagin, Vladimir A.; Israfilov, Ruslan A.

    2016-06-01

    Multidimensional unconstrained global optimization problem with objective function under Lipschitz condition is considered. For solving this problem the dimensionality reduction approach on the base of the nested optimization scheme is used. This scheme reduces initial multidimensional problem to a family of one-dimensional subproblems being Lipschitzian as well and thus allows applying univariate methods for the execution of multidimensional optimization. For two well-known one-dimensional methods of Lipschitz optimization the modifications providing the acceleration of the search process in the situation when the objective function is continuously differentiable in a vicinity of the global minimum are considered and compared. Results of computational experiments on conventional test class of multiextremal functions confirm efficiency of the modified methods.

  20. A Memetic Algorithm for Global Optimization of Multimodal Nonseparable Problems.

    PubMed

    Zhang, Geng; Li, Yangmin

    2016-06-01

    It is a big challenging issue of avoiding falling into local optimum especially when facing high-dimensional nonseparable problems where the interdependencies among vector elements are unknown. In order to improve the performance of optimization algorithm, a novel memetic algorithm (MA) called cooperative particle swarm optimizer-modified harmony search (CPSO-MHS) is proposed in this paper, where the CPSO is used for local search and the MHS for global search. The CPSO, as a local search method, uses 1-D swarm to search each dimension separately and thus converges fast. Besides, it can obtain global optimum elements according to our experimental results and analyses. MHS implements the global search by recombining different vector elements and extracting global optimum elements. The interaction between local search and global search creates a set of local search zones, where global optimum elements reside within the search space. The CPSO-MHS algorithm is tested and compared with seven other optimization algorithms on a set of 28 standard benchmarks. Meanwhile, some MAs are also compared according to the results derived directly from their corresponding references. The experimental results demonstrate a good performance of the proposed CPSO-MHS algorithm in solving multimodal nonseparable problems. PMID:26292352

  1. Optimizing human activity patterns using global sensitivity analysis

    DOE PAGESBeta

    Fairchild, Geoffrey; Hickmann, Kyle S.; Mniszewski, Susan M.; Del Valle, Sara Y.; Hyman, James M.

    2013-12-10

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule’s regularity for a population. We show how to tune an activity’s regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimizationmore » problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. Here we use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Finally, though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.« less

  2. Orbit design and optimization based on global telecommunication performance metrics

    NASA Technical Reports Server (NTRS)

    Lee, Seungwon; Lee, Charles H.; Kerridge, Stuart; Cheung, Kar-Ming; Edwards, Charles D.

    2006-01-01

    The orbit selection of telecommunications orbiters is one of the critical design processes and should be guided by global telecom performance metrics and mission-specific constraints. In order to aid the orbit selection, we have coupled the Telecom Orbit Analysis and Simulation Tool (TOAST) with genetic optimization algorithms. As a demonstration, we have applied the developed tool to select an optimal orbit for general Mars telecommunications orbiters with the constraint of being a frozen orbit. While a typical optimization goal is to minimize tele-communications down time, several relevant performance metrics are examined: 1) area-weighted average gap time, 2) global maximum of local maximum gap time, 3) global maximum of local minimum gap time. Optimal solutions are found with each of the metrics. Common and different features among the optimal solutions as well as the advantage and disadvantage of each metric are presented. The optimal solutions are compared with several candidate orbits that were considered during the development of Mars Telecommunications Orbiter.

  3. Application of clustering global optimization to thin film design problems.

    PubMed

    Lemarchand, Fabien

    2014-03-10

    Refinement techniques usually calculate an optimized local solution, which is strongly dependent on the initial formula used for the thin film design. In the present study, a clustering global optimization method is used which can iteratively change this initial formula, thereby progressing further than in the case of local optimization techniques. A wide panel of local solutions is found using this procedure, resulting in a large range of optical thicknesses. The efficiency of this technique is illustrated by two thin film design problems, in particular an infrared antireflection coating, and a solar-selective absorber coating. PMID:24663856

  4. A global optimization paradigm based on change of measures.

    PubMed

    Sarkar, Saikat; Roy, Debasish; Vasu, Ram Mohan

    2015-07-01

    A global optimization framework, COMBEO (Change Of Measure Based Evolutionary Optimization), is proposed. An important aspect in the development is a set of derivative-free additive directional terms, obtainable through a change of measures en route to the imposition of any stipulated conditions aimed at driving the realized design variables (particles) to the global optimum. The generalized setting offered by the new approach also enables several basic ideas, used with other global search methods such as the particle swarm or the differential evolution, to be rationally incorporated in the proposed set-up via a change of measures. The global search may be further aided by imparting to the directional update terms additional layers of random perturbations such as 'scrambling' and 'selection'. Depending on the precise choice of the optimality conditions and the extent of random perturbation, the search can be readily rendered either greedy or more exploratory. As numerically demonstrated, the new proposal appears to provide for a more rational, more accurate and, in some cases, a faster alternative to many available evolutionary optimization schemes. PMID:26587268

  5. Simple proof of the global optimality of the Hohmann transfer

    NASA Technical Reports Server (NTRS)

    Prussing, John E.

    1992-01-01

    The case of two-impulse transfer between coplanar circular orbits is considered. The global optimality of the Hohmann transfer among the class of two-impulse transfers is proved via ordinary calculus by using the familiar orbital elements, eccentricity e and parameter (semilatus rectum) p. It is noted that this proof is simpler than existing proofs in the literature.

  6. Global Optimal Trajectory in Chaos and NP-Hardness

    NASA Astrophysics Data System (ADS)

    Latorre, Vittorio; Gao, David Yang

    This paper presents an unconventional theory and method for solving general nonlinear dynamical systems. Instead of the direct iterative methods, the discretized nonlinear system is first formulated as a global optimization problem via the least squares method. A newly developed canonical duality theory shows that this nonconvex minimization problem can be solved deterministically in polynomial time if a global optimality condition is satisfied. The so-called pseudo-chaos produced by linear iterative methods are mainly due to the intrinsic numerical error accumulations. Otherwise, the global optimization problem could be NP-hard and the nonlinear system can be really chaotic. A conjecture is proposed, which reveals the connection between chaos in nonlinear dynamics and NP-hardness in computer science. The methodology and the conjecture are verified by applications to the well-known logistic equation, a forced memristive circuit and the Lorenz system. Computational results show that the canonical duality theory can be used to identify chaotic systems and to obtain realistic global optimal solutions in nonlinear dynamical systems. The method and results presented in this paper should bring some new insights into nonlinear dynamical systems and NP-hardness in computational complexity theory.

  7. A global optimization paradigm based on change of measures

    PubMed Central

    Sarkar, Saikat; Roy, Debasish; Vasu, Ram Mohan

    2015-01-01

    A global optimization framework, COMBEO (Change Of Measure Based Evolutionary Optimization), is proposed. An important aspect in the development is a set of derivative-free additive directional terms, obtainable through a change of measures en route to the imposition of any stipulated conditions aimed at driving the realized design variables (particles) to the global optimum. The generalized setting offered by the new approach also enables several basic ideas, used with other global search methods such as the particle swarm or the differential evolution, to be rationally incorporated in the proposed set-up via a change of measures. The global search may be further aided by imparting to the directional update terms additional layers of random perturbations such as ‘scrambling’ and ‘selection’. Depending on the precise choice of the optimality conditions and the extent of random perturbation, the search can be readily rendered either greedy or more exploratory. As numerically demonstrated, the new proposal appears to provide for a more rational, more accurate and, in some cases, a faster alternative to many available evolutionary optimization schemes. PMID:26587268

  8. Improved Particle Swarm Optimization for Global Optimization of Unimodal and Multimodal Functions

    NASA Astrophysics Data System (ADS)

    Basu, Mousumi

    2015-07-01

    Particle swarm optimization (PSO) performs well for small dimensional and less complicated problems but fails to locate global minima for complex multi-minima functions. This paper proposes an improved particle swarm optimization (IPSO) which introduces Gaussian random variables in velocity term. This improves search efficiency and guarantees a high probability of obtaining the global optimum without significantly impairing the speed of convergence and the simplicity of the structure of particle swarm optimization. The algorithm is experimentally validated on 17 benchmark functions and the results demonstrate good performance of the IPSO in solving unimodal and multimodal problems. Its high performance is verified by comparing with two popular PSO variants.

  9. Obstetricians’ Opinions of the Optimal Caesarean Rate: A Global Survey

    PubMed Central

    Cavallaro, Francesca L.; Cresswell, Jenny A.; Ronsmans, Carine

    2016-01-01

    Background The debate surrounding the optimal caesarean rate has been ongoing for several decades, with the WHO recommending an “acceptable” rate of 5–15% since 1997, despite a weak evidence base. Global expert opinion from obstetric care providers on the optimal caesarean rate has not been documented. The objective of this study was to examine providers’ opinions of the optimal caesarean rate worldwide, among all deliveries and within specific sub-groups of deliveries. Methods A global online survey of medical doctors who had performed at least one caesarean in the last five years was conducted between August 2013 and January 2014. Respondents were asked to report their opinion of the optimal caesarean rate—defined as the caesarean rate that would minimise poor maternal and perinatal outcomes—at the population level and within specific sub-groups of deliveries (including women with demographic and clinical risk factors for caesareans). Median reported optimal rates and corresponding inter-quartile ranges (IQRs) were calculated for the sample, and stratified according to national caesarean rate, institutional caesarean rate, facility level, and respondent characteristics. Results Responses were collected from 1,057 medical doctors from 96 countries. The median reported optimal caesarean rate was 20% (IQR: 15–30%) for all deliveries. Providers in private for-profit facilities and in facilities with high institutional rates reported optimal rates of 30% or above, while those in Europe, in public facilities and in facilities with low institutional rates reported rates of 15% or less. Reported optimal rates were lowest among low-risk deliveries and highest for Absolute Maternal Indications (AMIs), with wide IQRs observed for most categories other than AMIs. Conclusions Three-quarters of respondents reported an optimal caesarean rate above the WHO 15% upper threshold. There was substantial variation in responses, highlighting a lack of consensus around

  10. Hybrid methods using genetic algorithms for global optimization.

    PubMed

    Renders, J M; Flasse, S P

    1996-01-01

    This paper discusses the trade-off between accuracy, reliability and computing time in global optimization. Particular compromises provided by traditional methods (Quasi-Newton and Nelder-Mead's simplex methods) and genetic algorithms are addressed and illustrated by a particular application in the field of nonlinear system identification. Subsequently, new hybrid methods are designed, combining principles from genetic algorithms and "hill-climbing" methods in order to find a better compromise to the trade-off. Inspired by biology and especially by the manner in which living beings adapt themselves to their environment, these hybrid methods involve two interwoven levels of optimization, namely evolution (genetic algorithms) and individual learning (Quasi-Newton), which cooperate in a global process of optimization. One of these hybrid methods appears to join the group of state-of-the-art global optimization methods: it combines the reliability properties of the genetic algorithms with the accuracy of Quasi-Newton method, while requiring a computation time only slightly higher than the latter. PMID:18263027

  11. Automated parameterization of intermolecular pair potentials using global optimization techniques

    NASA Astrophysics Data System (ADS)

    Krämer, Andreas; Hülsmann, Marco; Köddermann, Thorsten; Reith, Dirk

    2014-12-01

    In this work, different global optimization techniques are assessed for the automated development of molecular force fields, as used in molecular dynamics and Monte Carlo simulations. The quest of finding suitable force field parameters is treated as a mathematical minimization problem. Intricate problem characteristics such as extremely costly and even abortive simulations, noisy simulation results, and especially multiple local minima naturally lead to the use of sophisticated global optimization algorithms. Five diverse algorithms (pure random search, recursive random search, CMA-ES, differential evolution, and taboo search) are compared to our own tailor-made solution named CoSMoS. CoSMoS is an automated workflow. It models the parameters' influence on the simulation observables to detect a globally optimal set of parameters. It is shown how and why this approach is superior to other algorithms. Applied to suitable test functions and simulations for phosgene, CoSMoS effectively reduces the number of required simulations and real time for the optimization task.

  12. Global optimization in systems biology: stochastic methods and their applications.

    PubMed

    Balsa-Canto, Eva; Banga, J R; Egea, J A; Fernandez-Villaverde, A; de Hijas-Liste, G M

    2012-01-01

    Mathematical optimization is at the core of many problems in systems biology: (1) as the underlying hypothesis for model development, (2) in model identification, or (3) in the computation of optimal stimulation procedures to synthetically achieve a desired biological behavior. These problems are usually formulated as nonlinear programing problems (NLPs) with dynamic and algebraic constraints. However the nonlinear and highly constrained nature of systems biology models, together with the usually large number of decision variables, can make their solution a daunting task, therefore calling for efficient and robust optimization techniques. Here, we present novel global optimization methods and software tools such as cooperative enhanced scatter search (eSS), AMIGO, or DOTcvpSB, and illustrate their possibilities in the context of modeling including model identification and stimulation design in systems biology. PMID:22161343

  13. Tabu search method with random moves for globally optimal design

    NASA Astrophysics Data System (ADS)

    Hu, Nanfang

    1992-09-01

    Optimum engineering design problems are usually formulated as non-convex optimization problems of continuous variables. Because of the absence of convexity structure, they can have multiple minima, and global optimization becomes difficult. Traditional methods of optimization, such as penalty methods, can often be trapped at a local optimum. The tabu search method with random moves to solve approximately these problems is introduced. Its reliability and efficiency are examined with the help of standard test functions. By the analysis of the implementations, it is seen that this method is easy to use, and no derivative information is necessary. It outperforms the random search method and composite genetic algorithm. In particular, it is applied to minimum weight design examples of a three-bar truss, coil springs, a Z-section and a channel section. For the channel section, the optimal design using the tabu search method with random moves saved 26.14 percent over the weight of the SUMT method.

  14. Globally Optimal Segmentation of Permanent-Magnet Systems

    NASA Astrophysics Data System (ADS)

    Insinga, A. R.; Bjørk, R.; Smith, A.; Bahl, C. R. H.

    2016-06-01

    Permanent-magnet systems are widely used for generation of magnetic fields with specific properties. The reciprocity theorem, an energy-equivalence principle in magnetostatics, can be employed to calculate the optimal remanent flux density of the permanent-magnet system, given any objective functional that is linear in the magnetic field. This approach, however, yields a continuously varying remanent flux density, while in practical applications, magnetic assemblies are realized by combining uniformly magnetized segments. The problem of determining the optimal shape of each of these segments remains unsolved. We show that the problem of optimal segmentation of a two-dimensional permanent-magnet assembly with respect to a linear objective functional can be reduced to the problem of piecewise linear approximation of a plane curve by perimeter maximization. Once the problem has been cast into this form, the globally optimal solution can be easily computed employing dynamic programming.

  15. Globally consistent registration of terrestrial laser scans via graph optimization

    NASA Astrophysics Data System (ADS)

    Theiler, Pascal Willy; Wegner, Jan Dirk; Schindler, Konrad

    2015-11-01

    In this paper we present a framework for the automatic registration of multiple terrestrial laser scans. The proposed method can handle arbitrary point clouds with reasonable pairwise overlap, without knowledge about their initial orientation and without the need for artificial markers or other specific objects. The framework is divided into a coarse and a fine registration part, which each start with pairwise registration and then enforce consistent global alignment across all scans. While we put forward a complete, functional registration system, the novel contribution of the paper lies in the coarse global alignment step. Merging multiple scans into a consistent network creates loops along which the relative transformations must add up. We pose the task of finding a global alignment as picking the best candidates from a set of putative pairwise registrations, such that they satisfy the loop constraints. This yields a discrete optimization problem that can be solved efficiently with modern combinatorial methods. Having found a coarse global alignment in this way, the framework proceeds by pairwise refinement with standard ICP, followed by global refinement to evenly spread the residual errors. The framework was tested on six challenging, real-world datasets. The discrete global alignment step effectively detects, removes and corrects failures of the pairwise registration procedure, finally producing a globally consistent coarse scan network which can be used as initial guess for the highly non-convex refinement. Our overall system reaches success rates close to 100% at acceptable runtimes < 1 h, even in challenging conditions such as scanning in the forest.

  16. Global Design Optimization for Aerodynamics and Rocket Propulsion Components

    NASA Technical Reports Server (NTRS)

    Shyy, Wei; Papila, Nilay; Vaidyanathan, Rajkumar; Tucker, Kevin; Turner, James E. (Technical Monitor)

    2000-01-01

    Modern computational and experimental tools for aerodynamics and propulsion applications have matured to a stage where they can provide substantial insight into engineering processes involving fluid flows, and can be fruitfully utilized to help improve the design of practical devices. In particular, rapid and continuous development in aerospace engineering demands that new design concepts be regularly proposed to meet goals for increased performance, robustness and safety while concurrently decreasing cost. To date, the majority of the effort in design optimization of fluid dynamics has relied on gradient-based search algorithms. Global optimization methods can utilize the information collected from various sources and by different tools. These methods offer multi-criterion optimization, handle the existence of multiple design points and trade-offs via insight into the entire design space, can easily perform tasks in parallel, and are often effective in filtering the noise intrinsic to numerical and experimental data. However, a successful application of the global optimization method needs to address issues related to data requirements with an increase in the number of design variables, and methods for predicting the model performance. In this article, we review recent progress made in establishing suitable global optimization techniques employing neural network and polynomial-based response surface methodologies. Issues addressed include techniques for construction of the response surface, design of experiment techniques for supplying information in an economical manner, optimization procedures and multi-level techniques, and assessment of relative performance between polynomials and neural networks. Examples drawn from wing aerodynamics, turbulent diffuser flows, gas-gas injectors, and supersonic turbines are employed to help demonstrate the issues involved in an engineering design context. Both the usefulness of the existing knowledge to aid current design

  17. Efficient global optimization of a limited parameter antenna design

    NASA Astrophysics Data System (ADS)

    O'Donnell, Teresa H.; Southall, Hugh L.; Kaanta, Bryan

    2008-04-01

    Efficient Global Optimization (EGO) is a competent evolutionary algorithm suited for problems with limited design parameters and expensive cost functions. Many electromagnetics problems, including some antenna designs, fall into this class, as complex electromagnetics simulations can take substantial computational effort. This makes simple evolutionary algorithms such as genetic algorithms or particle swarms very time-consuming for design optimization, as many iterations of large populations are usually required. When physical experiments are necessary to perform tradeoffs or determine effects which may not be simulated, use of these algorithms is simply not practical at all due to the large numbers of measurements required. In this paper we first present a brief introduction to the EGO algorithm. We then present the parasitic superdirective two-element array design problem and results obtained by applying EGO to obtain the optimal element separation and operating frequency to maximize the array directivity. We compare these results to both the optimal solution and results obtained by performing a similar optimization using the Nelder-Mead downhill simplex method. Our results indicate that, unlike the Nelder-Mead algorithm, the EGO algorithm did not become stuck in local minima but rather found the area of the correct global minimum. However, our implementation did not always drill down into the precise minimum and the addition of a local search technique seems to be indicated.

  18. New methods for large scale local and global optimization

    NASA Astrophysics Data System (ADS)

    Byrd, Richard; Schnabel, Robert

    1994-07-01

    We have pursued all three topics described in the proposal during this research period. A large amount of effort has gone into the development of large scale global optimization methods for molecular configuration problems. We have developed new general purpose methods that combine efficient stochastic global optimization techniques with several new, more deterministic techniques that account for most of the computational effort, and the success, of the methods. We have applied our methods to Lennard-Jones problems with up to 75 atoms, to water clusters with up to 31, molecules, and polymers with up to 58 amino acids. The results appear to be the best so far by general purpose optimization methods, and appear to be leading to some interesting chemistry issues. Our research on the second topic, tensor methods, has addressed several areas. We have designed and implemented tensor methods for large sparse systems of nonlinear equations and nonlinear least squares, and have obtained excellent test results on a wide range of problems. We have also developed new tensor methods for nonlinearly constrained optimization problem, and have obtained promising theoretical and preliminary computational results. Finally, on the third topic, limited memory methods for large scale optimization, we have developed and implemented new, extremely efficient limited memory methods for bound constrained problems, and new limited memory trust regions methods, both using our-recently developed compact representations for quasi-Newton matrices. Computational test results for both methods are promising.

  19. p-MEMPSODE: Parallel and irregular memetic global optimization

    NASA Astrophysics Data System (ADS)

    Voglis, C.; Hadjidoukas, P. E.; Parsopoulos, K. E.; Papageorgiou, D. G.; Lagaris, I. E.; Vrahatis, M. N.

    2015-12-01

    A parallel memetic global optimization algorithm suitable for shared memory multicore systems is proposed and analyzed. The considered algorithm combines two well-known and widely used population-based stochastic algorithms, namely Particle Swarm Optimization and Differential Evolution, with two efficient and parallelizable local search procedures. The sequential version of the algorithm was first introduced as MEMPSODE (MEMetic Particle Swarm Optimization and Differential Evolution) and published in the CPC program library. We exploit the inherent and highly irregular parallelism of the memetic global optimization algorithm by means of a dynamic and multilevel approach based on the OpenMP tasking model. In our case, tasks correspond to local optimization procedures or simple function evaluations. Parallelization occurs at each iteration step of the memetic algorithm without affecting its searching efficiency. The proposed implementation, for the same random seed, reaches the same solution irrespectively of being executed sequentially or in parallel. Extensive experimental evaluation has been performed in order to illustrate the speedup achieved on a shared-memory multicore server.

  20. A deterministic global optimization using smooth diagonal auxiliary functions

    NASA Astrophysics Data System (ADS)

    Sergeyev, Yaroslav D.; Kvasov, Dmitri E.

    2015-04-01

    In many practical decision-making problems it happens that functions involved in optimization process are black-box with unknown analytical representations and hard to evaluate. In this paper, a global optimization problem is considered where both the goal function f (x) and its gradient f‧ (x) are black-box functions. It is supposed that f‧ (x) satisfies the Lipschitz condition over the search hyperinterval with an unknown Lipschitz constant K. A new deterministic 'Divide-the-Best' algorithm based on efficient diagonal partitions and smooth auxiliary functions is proposed in its basic version, its convergence conditions are studied and numerical experiments executed on eight hundred test functions are presented.

  1. Imperialist competitive algorithm combined with chaos for global optimization

    NASA Astrophysics Data System (ADS)

    Talatahari, S.; Farahmand Azar, B.; Sheikholeslami, R.; Gandomi, A. H.

    2012-03-01

    A novel chaotic improved imperialist competitive algorithm (CICA) is presented for global optimization. The ICA is a new meta-heuristic optimization developed based on a socio-politically motivated strategy and contains two main steps: the movement of the colonies and the imperialistic competition. Here different chaotic maps are utilized to improve the movement step of the algorithm. Seven different chaotic maps are investigated and the Logistic and Sinusoidal maps are found as the best choices. Comparing the new algorithm with the other ICA-based methods demonstrates the superiority of the CICA for the benchmark functions.

  2. Global optimization using the y-ybar diagram

    NASA Astrophysics Data System (ADS)

    Brown, Daniel M.

    1991-12-01

    Software is under development at Teledyne Brown Engineering to represent a lens configuration as a y-ybar or Delano diagram. The program determines third-order Seidel and chromatic aberrations for each configuration. It performs a global search through all valid permutations of configuration space and determines, to within a step increment of the space, the configuration with smallest third-order aberrations. The program was developed to generate first-order optical layouts which promised to reach global minima during subsequent conventional optimization. Other operations allowed by the program are: add or delete surfaces, couple surfaces (for Mangin mirrors), shift the stop position, and display first-order properties and the optical layout (surface radii and thicknesses) for subsequent entry into a conventional lens-design program with automatic optimization. Algorithms for performing some of the key functions, not covered by previous authors, are discussed in this paper.

  3. Multi-fidelity global design optimization including parallelization potential

    NASA Astrophysics Data System (ADS)

    Cox, Steven Edward

    The DIRECT global optimization algorithm is a relatively new space partitioning algorithm designed to determine the globally optimal design within a designated design space. This dissertation examines the applicability of the DIRECT algorithm to two classes of design problems: unimodal functions where small amplitude, high frequency fluctuations in the objective function make optimization difficult; and multimodal functions where multiple local optima are formed by the underlying physics of the problem (as opposed to minor fluctuations in the analysis code). DIRECT is compared with two other multistart local optimization techniques on two polynomial test problems and one engineering conceptual design problem. Three modifications to the DIRECT algorithm are proposed to increase the effectiveness of the algorithm. The DIRECT-BP algorithm is presented which alters the way DIRECT searches the neighborhood of the current best point as optimization progresses. The algorithm reprioritizes which points to analyze at each iteration. This is to encourage analysis of points that surround the best point but that are farther away than the points selected by the DIRECT algorithm. This increases the robustness of the DIRECT search and provides more information on the characteristics of the neighborhood of the point selected as the global optimum. A multifidelity version of the DIRECT algorithm is proposed to reduce the cost of optimization using DIRECT. By augmenting expensive high-fidelity analysis with cheap low-fidelity analysis, the optimization can be performed with fewer high-fidelity analyses. Two correction schemes are examined using high- and low-fidelity results at one point to correct the low-fidelity result at a nearby point. This corrected value is then used in place of a high-fidelity analysis by the DIRECT algorithm. In this way the number of high-fidelity analyses required is reduced and the optimization became less expensive. Finally the DIRECT algorithm is

  4. Asynchronous global optimization techniques for medium and large inversion problems

    SciTech Connect

    Pereyra, V.; Koshy, M.; Meza, J.C.

    1995-04-01

    We discuss global optimization procedures adequate for seismic inversion problems. We explain how to save function evaluations (which may involve large scale ray tracing or other expensive operations) by creating a data base of information on what parts of parameter space have already been inspected. It is also shown how a correct parallel implementation using PVM speeds up the process almost linearly with respect to the number of processors, provided that the function evaluations are expensive enough to offset the communication overhead.

  5. Globally optimal surface mapping for surfaces with arbitrary topology.

    PubMed

    Li, Xin; Bao, Yunfan; Guo, Xiaohu; Jin, Miao; Gu, Xianfeng; Qin, Hong

    2008-01-01

    Computing smooth and optimal one-to-one maps between surfaces of same topology is a fundamental problem in computer graphics and such a method provides us a ubiquitous tool for geometric modeling and data visualization. Its vast variety of applications includes shape registration/matching, shape blending, material/data transfer, data fusion, information reuse, etc. The mapping quality is typically measured in terms of angular distortions among different shapes. This paper proposes and develops a novel quasi-conformal surface mapping framework to globally minimize the stretching energy inevitably introduced between two different shapes. The existing state-of-the-art inter-surface mapping techniques only afford local optimization either on surface patches via boundary cutting or on the simplified base domain, lacking rigorous mathematical foundation and analysis. We design and articulate an automatic variational algorithm that can reach the global distortion minimum for surface mapping between shapes of arbitrary topology, and our algorithm is sorely founded upon the intrinsic geometry structure of surfaces. To our best knowledge, this is the first attempt towards numerically computing globally optimal maps. Consequently, our mapping framework offers a powerful computational tool for graphics and visualization tasks such as data and texture transfer, shape morphing, and shape matching. PMID:18467756

  6. Multidisciplinary optimization of controlled space structures with global sensitivity equations

    NASA Technical Reports Server (NTRS)

    Padula, Sharon L.; James, Benjamin B.; Graves, Philip C.; Woodard, Stanley E.

    1991-01-01

    A new method for the preliminary design of controlled space structures is presented. The method coordinates standard finite element structural analysis, multivariable controls, and nonlinear programming codes and allows simultaneous optimization of the structures and control systems of a spacecraft. Global sensitivity equations are a key feature of this method. The preliminary design of a generic geostationary platform is used to demonstrate the multidisciplinary optimization method. Fifteen design variables are used to optimize truss member sizes and feedback gain values. The goal is to reduce the total mass of the structure and the vibration control system while satisfying constraints on vibration decay rate. Incorporating the nonnegligible mass of actuators causes an essential coupling between structural design variables and control design variables. The solution of the demonstration problem is an important step toward a comprehensive preliminary design capability for structures and control systems. Use of global sensitivity equations helps solve optimization problems that have a large number of design variables and a high degree of coupling between disciplines.

  7. Proposal of Evolutionary Simplex Method for Global Optimization Problem

    NASA Astrophysics Data System (ADS)

    Shimizu, Yoshiaki

    To make an agile decision in a rational manner, role of optimization engineering has been notified increasingly under diversified customer demand. With this point of view, in this paper, we have proposed a new evolutionary method serving as an optimization technique in the paradigm of optimization engineering. The developed method has prospects to solve globally various complicated problem appearing in real world applications. It is evolved from the conventional method known as Nelder and Mead’s Simplex method by virtue of idea borrowed from recent meta-heuristic method such as PSO. Mentioning an algorithm to handle linear inequality constraints effectively, we have validated effectiveness of the proposed method through comparison with other methods using several benchmark problems.

  8. Nonlinear Inertia Weighted Teaching-Learning-Based Optimization for Solving Global Optimization Problem

    PubMed Central

    Wu, Zong-Sheng; Fu, Wei-Ping; Xue, Ru

    2015-01-01

    Teaching-learning-based optimization (TLBO) algorithm is proposed in recent years that simulates the teaching-learning phenomenon of a classroom to effectively solve global optimization of multidimensional, linear, and nonlinear problems over continuous spaces. In this paper, an improved teaching-learning-based optimization algorithm is presented, which is called nonlinear inertia weighted teaching-learning-based optimization (NIWTLBO) algorithm. This algorithm introduces a nonlinear inertia weighted factor into the basic TLBO to control the memory rate of learners and uses a dynamic inertia weighted factor to replace the original random number in teacher phase and learner phase. The proposed algorithm is tested on a number of benchmark functions, and its performance comparisons are provided against the basic TLBO and some other well-known optimization algorithms. The experiment results show that the proposed algorithm has a faster convergence rate and better performance than the basic TLBO and some other algorithms as well. PMID:26421005

  9. Global structual optimizations of surface systems with a genetic algorithm

    SciTech Connect

    Chuang, Feng-Chuan

    2005-05-01

    Global structural optimizations with a genetic algorithm were performed for atomic cluster and surface systems including aluminum atomic clusters, Si magic clusters on the Si(111) 7 x 7 surface, silicon high-index surfaces, and Ag-induced Si(111) reconstructions. First, the global structural optimizations of neutral aluminum clusters Al{sub n} (n up to 23) were performed using a genetic algorithm coupled with a tight-binding potential. Second, a genetic algorithm in combination with tight-binding and first-principles calculations were performed to study the structures of magic clusters on the Si(111) 7 x 7 surface. Extensive calculations show that the magic cluster observed in scanning tunneling microscopy (STM) experiments consist of eight Si atoms. Simulated STM images of the Si magic cluster exhibit a ring-like feature similar to STM experiments. Third, a genetic algorithm coupled with a highly optimized empirical potential were used to determine the lowest energy structure of high-index semiconductor surfaces. The lowest energy structures of Si(105) and Si(114) were determined successfully. The results of Si(105) and Si(114) are reported within the framework of highly optimized empirical potential and first-principles calculations. Finally, a genetic algorithm coupled with Si and Ag tight-binding potentials were used to search for Ag-induced Si(111) reconstructions at various Ag and Si coverages. The optimized structural models of {radical}3 x {radical}3, 3 x 1, and 5 x 2 phases were reported using first-principles calculations. A novel model is found to have lower surface energy than the proposed double-honeycomb chained (DHC) model both for Au/Si(111) 5 x 2 and Ag/Si(111) 5 x 2 systems.

  10. A global optimization approach to multi-polarity sentiment analysis.

    PubMed

    Li, Xinmiao; Li, Jing; Wu, Yukeng

    2015-01-01

    Following the rapid development of social media, sentiment analysis has become an important social media mining technique. The performance of automatic sentiment analysis primarily depends on feature selection and sentiment classification. While information gain (IG) and support vector machines (SVM) are two important techniques, few studies have optimized both approaches in sentiment analysis. The effectiveness of applying a global optimization approach to sentiment analysis remains unclear. We propose a global optimization-based sentiment analysis (PSOGO-Senti) approach to improve sentiment analysis with IG for feature selection and SVM as the learning engine. The PSOGO-Senti approach utilizes a particle swarm optimization algorithm to obtain a global optimal combination of feature dimensions and parameters in the SVM. We evaluate the PSOGO-Senti model on two datasets from different fields. The experimental results showed that the PSOGO-Senti model can improve binary and multi-polarity Chinese sentiment analysis. We compared the optimal feature subset selected by PSOGO-Senti with the features in the sentiment dictionary. The results of this comparison indicated that PSOGO-Senti can effectively remove redundant and noisy features and can select a domain-specific feature subset with a higher-explanatory power for a particular sentiment analysis task. The experimental results showed that the PSOGO-Senti approach is effective and robust for sentiment analysis tasks in different domains. By comparing the improvements of two-polarity, three-polarity and five-polarity sentiment analysis results, we found that the five-polarity sentiment analysis delivered the largest improvement. The improvement of the two-polarity sentiment analysis was the smallest. We conclude that the PSOGO-Senti achieves higher improvement for a more complicated sentiment analysis task. We also compared the results of PSOGO-Senti with those of the genetic algorithm (GA) and grid search method. From

  11. A Global Optimization Approach to Multi-Polarity Sentiment Analysis

    PubMed Central

    Li, Xinmiao; Li, Jing; Wu, Yukeng

    2015-01-01

    Following the rapid development of social media, sentiment analysis has become an important social media mining technique. The performance of automatic sentiment analysis primarily depends on feature selection and sentiment classification. While information gain (IG) and support vector machines (SVM) are two important techniques, few studies have optimized both approaches in sentiment analysis. The effectiveness of applying a global optimization approach to sentiment analysis remains unclear. We propose a global optimization-based sentiment analysis (PSOGO-Senti) approach to improve sentiment analysis with IG for feature selection and SVM as the learning engine. The PSOGO-Senti approach utilizes a particle swarm optimization algorithm to obtain a global optimal combination of feature dimensions and parameters in the SVM. We evaluate the PSOGO-Senti model on two datasets from different fields. The experimental results showed that the PSOGO-Senti model can improve binary and multi-polarity Chinese sentiment analysis. We compared the optimal feature subset selected by PSOGO-Senti with the features in the sentiment dictionary. The results of this comparison indicated that PSOGO-Senti can effectively remove redundant and noisy features and can select a domain-specific feature subset with a higher-explanatory power for a particular sentiment analysis task. The experimental results showed that the PSOGO-Senti approach is effective and robust for sentiment analysis tasks in different domains. By comparing the improvements of two-polarity, three-polarity and five-polarity sentiment analysis results, we found that the five-polarity sentiment analysis delivered the largest improvement. The improvement of the two-polarity sentiment analysis was the smallest. We conclude that the PSOGO-Senti achieves higher improvement for a more complicated sentiment analysis task. We also compared the results of PSOGO-Senti with those of the genetic algorithm (GA) and grid search method. From

  12. Joint global optimization of tomographic data based on particle swarm optimization and decision theory

    NASA Astrophysics Data System (ADS)

    Paasche, H.; Tronicke, J.

    2012-04-01

    In many near surface geophysical applications multiple tomographic data sets are routinely acquired to explore subsurface structures and parameters. Linking the model generation process of multi-method geophysical data sets can significantly reduce ambiguities in geophysical data analysis and model interpretation. Most geophysical inversion approaches rely on local search optimization methods used to find an optimal model in the vicinity of a user-given starting model. The final solution may critically depend on the initial model. Alternatively, global optimization (GO) methods have been used to invert geophysical data. They explore the solution space in more detail and determine the optimal model independently from the starting model. Additionally, they can be used to find sets of optimal models allowing a further analysis of model parameter uncertainties. Here we employ particle swarm optimization (PSO) to realize the global optimization of tomographic data. PSO is an emergent methods based on swarm intelligence characterized by fast and robust convergence towards optimal solutions. The fundamental principle of PSO is inspired by nature, since the algorithm mimics the behavior of a flock of birds searching food in a search space. In PSO, a number of particles cruise a multi-dimensional solution space striving to find optimal model solutions explaining the acquired data. The particles communicate their positions and success and direct their movement according to the position of the currently most successful particle of the swarm. The success of a particle, i.e. the quality of the currently found model by a particle, must be uniquely quantifiable to identify the swarm leader. When jointly inverting disparate data sets, the optimization solution has to satisfy multiple optimization objectives, at least one for each data set. Unique determination of the most successful particle currently leading the swarm is not possible. Instead, only statements about the Pareto

  13. Solving Globally-Optimal Threading Problems in ''Polynomial-Time''

    SciTech Connect

    Uberbacher, E.C.; Xu, D.; Xu, Y.

    1999-04-12

    Computational protein threading is a powerful technique for recognizing native-like folds of a protein sequence from a protein fold database. In this paper, we present an improved algorithm (over our previous work) for solving the globally-optimal threading problem, and illustrate how the computational complexity and the fold recognition accuracy of the algorithm change as the cutoff distance for pairwise interactions changes. For a given fold of m residues and M core secondary structures (or simply cores) and a protein sequence of n residues, the algorithm guarantees to find a sequence-fold alignment (threading) that is globally optimal, measured collectively by (1) the singleton match fitness, (2) pairwise interaction preference, and (3) alignment gap penalties, in O(mn + MnN{sup 1.5C-1}) time and O(mn + nN{sup C-1}) space. C, the topological complexity of a fold as we term, is a value which characterizes the overall structure of the considered pairwise interactions in the fold, which are typically determined by a specified cutoff distance between the beta carbon atoms of a pair of amino acids in the fold. C is typically a small positive integer. N represents the maximum number of possible alignments between an individual core of the fold and the protein sequence when its neighboring cores are already aligned, and its value is significantly less than n. When interacting amino acids are required to see each other, C is bounded from above by a small integer no matter how large the cutoff distance is. This indicates that the protein threading problem is polynomial-time solvable if the condition of seeing each other between interacting amino acids is sufficient for accurate fold recognition. A number of extensions have been made to our basic threading algorithm to allow finding a globally-optimal threading under various constraints, which include consistencies with (1) specified secondary structures (both cores and loops), (2) disulfide bonds, (3) active sites, etc.

  14. PROSPECT: A Computer System for Globally-Optimal Threading

    SciTech Connect

    Xu, D.; Xu, Y.

    1999-08-06

    This paper presents a new computer system, PROSPECT, for protein threading. PROSPECT employs an energy function that consists of three additive terms: (1) a singleton fitness term, (2) a distance-dependent pairwise-interaction preference term, and (3) alignment gap penalty; and currently uses FSSP as its threading template database. PROSPECT uses a divide-and-conquer algorithm to find an alignment between a query protein sequence and a protein fold template, which is guaranteed to be globally optimal for its energy function. The threading algorithm presented here significantly improves the computational efficiency of our previously-published algorithm, which makes PROSPECT a practical tool even for large protein threading problems. Mathematically, PROSPECT finds a globally-optimal threading between a query sequence of n residues and a fold template of m residues and M core secondary structures in O(nm + MnN{sup 1.5C{minus}1}) time and O(nm + nN{sup C{minus}1}) space, where C, the topological complexity of the template fold as we term, is a value which characterizes the overall structure of the considered pairwise interactions in the fold; and N represents the maximum number of possible alignments between an individual core of the fold and the query sequence when its neighboring cores are already aligned. PROSPECT allows a user to incorporate known biological constraints about the query sequence during the threading process. For given constraints, the system finds a globally-optimal threading which satisfies the constraints. Currently PROSPECT can deal with constraints which reflect geometrical relationships among residues of disulfide bonds, active sites, or determined by the NOE constraints of (low-resolution) NMR spectral data.

  15. Global optimization of minority game by intelligent agents

    NASA Astrophysics Data System (ADS)

    Xie, Yan-Bo; Wang, Bing-Hong; Hu, Chin-Kun; Zhou, Tao

    2005-10-01

    We propose a new model of minority game with intelligent agents who use trail and error method to make a choice such that the standard deviation σ2 and the total loss in this model reach the theoretical minimum values in the long time limit and the global optimization of the system is reached. This suggests that the economic systems can self-organize into a highly optimized state by agents who make decisions based on inductive thinking, limited knowledge, and capabilities. When other kinds of agents are also present, the simulation results and analytic calculations show that the intelligent agent can gain profits from producers and are much more competent than the noise traders and conventional agents in original minority games proposed by Challet and Zhang.

  16. An Adaptive Unified Differential Evolution Algorithm for Global Optimization

    SciTech Connect

    Qiang, Ji; Mitchell, Chad

    2014-11-03

    In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the multiple mutation strate- gies proposed in conventional differential evolution algorithms, this algorithm employs a single equation unifying multiple strategies into one expression. It has the virtue of mathematical simplicity and also provides users the flexibility for broader exploration of the space of mutation operators. By making all control parameters in the proposed algorithm self-adaptively evolve during the process of optimization, it frees the application users from the burden of choosing appro- priate control parameters and also improves the performance of the algorithm. In numerical tests using thirteen basic unimodal and multimodal functions, the proposed adaptive unified algorithm shows promising performance in compari- son to several conventional differential evolution algorithms.

  17. A Unified Differential Evolution Algorithm for Global Optimization

    SciTech Connect

    Qiang, Ji; Mitchell, Chad

    2014-06-24

    Abstract?In this paper, we propose a new unified differential evolution (uDE) algorithm for single objective global optimization. Instead of selecting among multiple mutation strategies as in the conventional differential evolution algorithm, this algorithm employs a single equation as the mutation strategy. It has the virtue of mathematical simplicity and also provides users the flexbility for broader exploration of different mutation strategies. Numerical tests using twelve basic unimodal and multimodal functions show promising performance of the proposed algorithm in comparison to convential differential evolution algorithms.

  18. Optimizing a global alignment of protein interaction networks

    PubMed Central

    Chindelevitch, Leonid; Ma, Cheng-Yu; Liao, Chung-Shou; Berger, Bonnie

    2013-01-01

    Motivation: The global alignment of protein interaction networks is a widely studied problem. It is an important first step in understanding the relationship between the proteins in different species and identifying functional orthologs. Furthermore, it can provide useful insights into the species’ evolution. Results: We propose a novel algorithm, PISwap, for optimizing global pairwise alignments of protein interaction networks, based on a local optimization heuristic that has previously demonstrated its effectiveness for a variety of other intractable problems. PISwap can begin with different types of network alignment approaches and then iteratively adjust the initial alignments by incorporating network topology information, trading it off for sequence information. In practice, our algorithm efficiently refines other well-studied alignment techniques with almost no additional time cost. We also show the robustness of the algorithm to noise in protein interaction data. In addition, the flexible nature of this algorithm makes it suitable for different applications of network alignment. This algorithm can yield interesting insights into the evolutionary dynamics of related species. Availability: Our software is freely available for non-commercial purposes from our Web site, http://piswap.csail.mit.edu/. Contact: bab@csail.mit.edu or csliao@ie.nthu.edu.tw Supplementary information: Supplementary data are available at Bioinformatics online. PMID:24048352

  19. Spectral Approach to Optimal Estimation of the Global Average Temperature.

    NASA Astrophysics Data System (ADS)

    Shen, Samuel S. P.; North, Gerald R.; Kim, Kwang-Y.

    1994-12-01

    Making use of EOF analysis and statistical optimal averaging techniques, the problem of random sampling error in estimating the global average temperature by a network of surface stations has been investigated. The EOF representation makes it unnecessary to use simplified empirical models of the correlation structure of temperature anomalies. If an adjustable weight is assigned to each station according to the criterion of minimum mean-square error, a formula for this error can be derived that consists of a sum of contributions from successive EOF modes. The EOFs were calculated from both observed data and a noise-forced EBM for the problem of one-year and five-year averages. The mean square statistical sampling error depends on the spatial distribution of the stations, length of the averaging interval, and the choice of the weight for each station data stream. Examples used here include four symmetric configurations of 4 × 4, 6 × 4, 9 × 7, and 20 × 10 stations and the Angell-Korshover configuration. Comparisons with the 100-yr U.K. dataset show that correlations for the time series of the global temperature anomaly average between the full dataset and this study's sparse configurations are rather high. For example, the 63-station Angell-Korshover network with uniform weighting explains 92.7% of the total variance, whereas the same network with optimal weighting can lead to 97.8% explained total variance of the U.K. dataset.

  20. Spectral approach to optimal estimation of the global average temperature

    SciTech Connect

    Shen, S.S.P.; North, G.R.; Kim, K.Y.

    1994-12-01

    Making use of EOF analysis and statistical optimal averaging techniques, the problem of random sampling error in estimating the global average temperature by a network of surface stations has been investigated. The EOF representation makes it unnecessary to use simplified empirical models of the correlation structure of temperature anomalies. If an adjustable weight is assigned to each station according to the criterion of minimum mean-square error, a formula for this error can be derived that consists of a sum of contributions from successive EOF modes. The EOFs were calculated from both observed data a noise-forced EBM for the problem of one-year and five-year averages. The mean square statistical sampling error depends on the spatial distribution of the stations, length of the averaging interval, and the choice of the weight for each station data stream. Examples used here include four symmetric configurations of 4 X 4, 5 X 4, 9 X 7, and 20 X 10 stations and the Angell-Korshover configuration. Comparisons with the 100-yr U.K. dataset show that correlations for the time series of the global temperature anomaly average between the full dataset and this study`s sparse configurations are rather high. For example, the 63-station Angell-Korshover network with uniform weighting explains 92.7% of the total variance, whereas the same network with optimal weighting can lead to 97.8% explained total variance of the U.K. dataset. 27 refs., 5 figs., 4 tabs.

  1. New Algorithms for Global Optimization and Reaction Path Determination.

    PubMed

    Weber, D; Bellinger, D; Engels, B

    2016-01-01

    We present new schemes to improve the convergence of an important global optimization problem and to determine reaction pathways (RPs) between identified minima. Those methods have been implemented into the CAST program (Conformational Analysis and Search Tool). The first part of this chapter shows how to improve convergence of the Monte Carlo with minimization (MCM, also known as Basin Hopping) method when applied to optimize water clusters or aqueous solvation shells using a simple model. Since the random movement on the potential energy surface (PES) is an integral part of MCM, we propose to employ a hydrogen bonding-based algorithm for its improvement. We show comparisons of the results obtained for random dihedral and for the proposed random, rigid-body water molecule movement, giving evidence that a specific adaption of the distortion process greatly improves the convergence of the method. The second part is about the determination of RPs in clusters between conformational arrangements and for reactions. Besides standard approaches like the nudged elastic band method, we want to focus on a new algorithm developed especially for global reaction path search called Pathopt. We started with argon clusters, a typical benchmark system, which possess a flat PES, then stepwise increase the magnitude and directionality of interactions. Therefore, we calculated pathways for a water cluster and characterize them by frequency calculations. Within our calculations, we were able to show that beneath local pathways also additional pathways can be found which possess additional features. PMID:27497166

  2. GenMin: An enhanced genetic algorithm for global optimization

    NASA Astrophysics Data System (ADS)

    Tsoulos, Ioannis G.; Lagaris, I. E.

    2008-06-01

    A new method that employs grammatical evolution and a stopping rule for finding the global minimum of a continuous multidimensional, multimodal function is considered. The genetic algorithm used is a hybrid genetic algorithm in conjunction with a local search procedure. We list results from numerical experiments with a series of test functions and we compare with other established global optimization methods. The accompanying software accepts objective functions coded either in Fortran 77 or in C++. Program summaryProgram title: GenMin Catalogue identifier: AEAR_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAR_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 35 810 No. of bytes in distributed program, including test data, etc.: 436 613 Distribution format: tar.gz Programming language: GNU-C++, GNU-C, GNU Fortran 77 Computer: The tool is designed to be portable in all systems running the GNU C++ compiler Operating system: The tool is designed to be portable in all systems running the GNU C++ compiler RAM: 200 KB Word size: 32 bits Classification: 4.9 Nature of problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques are frequently trapped in local minima. Global optimization is hence the appropriate tool. For example, solving a nonlinear system of equations via optimization, employing a least squares type of objective, one may encounter many local minima that do not correspond to solutions (i.e. they are far from zero). Solution method: Grammatical evolution and a stopping rule. Running time: Depending on the

  3. GMG: A Guaranteed, Efficient Global Optimization Algorithm for Remote Sensing.

    SciTech Connect

    D'Helon, CD

    2004-08-18

    The monocular passive ranging (MPR) problem in remote sensing consists of identifying the precise range of an airborne target (missile, plane, etc.) from its observed radiance. This inverse problem may be set as a global optimization problem (GOP) whereby the difference between the observed and model predicted radiances is minimized over the possible ranges and atmospheric conditions. Using additional information about the error function between the predicted and observed radiances of the target, we developed GMG, a new algorithm to find the Global Minimum with a Guarantee. The new algorithm transforms the original continuous GOP into a discrete search problem, thereby guaranteeing to find the position of the global minimum in a reasonably short time. The algorithm is first applied to the golf course problem, which serves as a litmus test for its performance in the presence of both complete and degraded additional information. GMG is further assessed on a set of standard benchmark functions and then applied to various realizations of the MPR problem.

  4. GMG - A guaranteed global optimization algorithm: Application to remote sensing

    SciTech Connect

    D'Helon, Cassius; Protopopescu, Vladimir A; Wells, Jack C; Barhen, Jacob

    2007-01-01

    We investigate the role of additional information in reducing the computational complexity of the global optimization problem (GOP). Following this approach, we develop GMG -- an algorithm to find the Global Minimum with a Guarantee. The new algorithm breaks up an originally continuous GOP into a discrete (grid) search problem followed by a descent problem. The discrete search identifies the basin of attraction of the global minimum after which the actual location of the minimizer is found upon applying a descent algorithm. The algorithm is first applied to the golf course problem, which serves as a litmus test for its performance in the presence of both complete and degraded additional information. GMG is further assessed on a set of standard benchmark functions. We then illustrate the performance of the the validated algorithm on a simple realization of the monocular passive ranging (MPR) problem in remote sensing, which consists of identifying the range of an airborne target (missile, plane, etc.) from its observed radiance. This inverse problem is set as a GOP whereby the difference between the observed and model predicted radiances is minimized over the possible ranges and atmospheric conditions. We solve the GOP using GMG and report on the performance of the algorithm.

  5. Parallel global optimization with the particle swarm algorithm

    PubMed Central

    Schutte, J. F.; Reinbolt, J. A.; Fregly, B. J.; Haftka, R. T.; George, A. D.

    2007-01-01

    SUMMARY Present day engineering optimization problems often impose large computational demands, resulting in long solution times even on a modern high-end processor. To obtain enhanced computational throughput and global search capability, we detail the coarse-grained parallelization of an increasingly popular global search method, the particle swarm optimization (PSO) algorithm. Parallel PSO performance was evaluated using two categories of optimization problems possessing multiple local minima—large-scale analytical test problems with computationally cheap function evaluations and medium-scale biomechanical system identification problems with computationally expensive function evaluations. For load-balanced analytical test problems formulated using 128 design variables, speedup was close to ideal and parallel efficiency above 95% for up to 32 nodes on a Beowulf cluster. In contrast, for load-imbalanced biomechanical system identification problems with 12 design variables, speedup plateaued and parallel efficiency decreased almost linearly with increasing number of nodes. The primary factor affecting parallel performance was the synchronization requirement of the parallel algorithm, which dictated that each iteration must wait for completion of the slowest fitness evaluation. When the analytical problems were solved using a fixed number of swarm iterations, a single population of 128 particles produced a better convergence rate than did multiple independent runs performed using sub-populations (8 runs with 16 particles, 4 runs with 32 particles, or 2 runs with 64 particles). These results suggest that (1) parallel PSO exhibits excellent parallel performance under load-balanced conditions, (2) an asynchronous implementation would be valuable for real-life problems subject to load imbalance, and (3) larger population sizes should be considered when multiple processors are available. PMID:17891226

  6. A framework for parallelized efficient global optimization with application to vehicle crashworthiness optimization

    NASA Astrophysics Data System (ADS)

    Hamza, Karim; Shalaby, Mohamed

    2014-09-01

    This article presents a framework for simulation-based design optimization of computationally expensive problems, where economizing the generation of sample designs is highly desirable. One popular approach for such problems is efficient global optimization (EGO), where an initial set of design samples is used to construct a kriging model, which is then used to generate new 'infill' sample designs at regions of the search space where there is high expectancy of improvement. This article attempts to address one of the limitations of EGO, where generation of infill samples can become a difficult optimization problem in its own right, as well as allow the generation of multiple samples at a time in order to take advantage of parallel computing in the evaluation of the new samples. The proposed approach is tested on analytical functions, and then applied to the vehicle crashworthiness design of a full Geo Metro model undergoing frontal crash conditions.

  7. Global Optimization and Broadband Analysis Software for Interstellar Chemistry (GOBASIC)

    NASA Astrophysics Data System (ADS)

    Rad, Mary L.; Zou, Luyao; Sanders, James L.; Widicus Weaver, Susanna L.

    2016-01-01

    Context. Broadband receivers that operate at millimeter and submillimeter frequencies necessitate the development of new tools for spectral analysis and interpretation. Simultaneous, global, multimolecule, multicomponent analysis is necessary to accurately determine the physical and chemical conditions from line-rich spectra that arise from sources like hot cores. Aims: We aim to provide a robust and efficient automated analysis program to meet the challenges presented with the large spectral datasets produced by radio telescopes. Methods: We have written a program in the MATLAB numerical computing environment for simultaneous global analysis of broadband line surveys. The Global Optimization and Broadband Analysis Software for Interstellar Chemistry (GOBASIC) program uses the simplifying assumption of local thermodynamic equilibrium (LTE) for spectral analysis to determine molecular column density, temperature, and velocity information. Results: GOBASIC achieves simultaneous, multimolecule, multicomponent fitting for broadband spectra. The number of components that can be analyzed at once is only limited by the available computational resources. Analysis of subsequent sets of molecules or components is performed iteratively while taking the previous fits into account. All features of a given molecule across the entire window are fitted at once, which is preferable to the rotation diagram approach because global analysis is less sensitive to blended features and noise features in the spectra. In addition, the fitting method used in GOBASIC is insensitive to the initial conditions chosen, the fitting is automated, and fitting can be performed in a parallel computing environment. These features make GOBASIC a valuable improvement over previously available LTE analysis methods. A copy of the sofware is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/585/A23

  8. Adjusting process count on demand for petascale global optimization

    SciTech Connect

    Sosonkina, Masha; Watson, Layne T.; Radcliffe, Nicholas R.; Haftka, Rafael T.; Trosset, Michael W.

    2012-11-23

    There are many challenges that need to be met before efficient and reliable computation at the petascale is possible. Many scientific and engineering codes running at the petascale are likely to be memory intensive, which makes thrashing a serious problem for many petascale applications. One way to overcome this challenge is to use a dynamic number of processes, so that the total amount of memory available for the computation can be increased on demand. This paper describes modifications made to the massively parallel global optimization code pVTdirect in order to allow for a dynamic number of processes. In particular, the modified version of the code monitors memory use and spawns new processes if the amount of available memory is determined to be insufficient. The primary design challenges are discussed, and performance results are presented and analyzed.

  9. Two-level global optimization for image segmentation

    NASA Astrophysics Data System (ADS)

    Pan, He-Ping

    Domain-independent image segmentation is considered here as a global optimization problem: to seek the simplest description of a given input image in terms of coherent closed regions. The approach consists of two levels of processing: pixel-level and region-level, both based on the Minimum-Description-Length principle. Pixel-level processing leads to forming the atomic regions that are then labelled. In region-level processing neighbouring regions are merged into larger ones using an explicit attributed graph evolution mechanism. Both level processings are stopped automatically without using any heuristic control parameters. Experiments are carried out with a number of images of different scene types. Parallel implementation of region-level processing is the most difficult problem to be solved for the operational application of this approach.

  10. Gradient gravitational search: An efficient metaheuristic algorithm for global optimization.

    PubMed

    Dash, Tirtharaj; Sahu, Prabhat K

    2015-05-30

    The adaptation of novel techniques developed in the field of computational chemistry to solve the concerned problems for large and flexible molecules is taking the center stage with regard to efficient algorithm, computational cost and accuracy. In this article, the gradient-based gravitational search (GGS) algorithm, using analytical gradients for a fast minimization to the next local minimum has been reported. Its efficiency as metaheuristic approach has also been compared with Gradient Tabu Search and others like: Gravitational Search, Cuckoo Search, and Back Tracking Search algorithms for global optimization. Moreover, the GGS approach has also been applied to computational chemistry problems for finding the minimal value potential energy of two-dimensional and three-dimensional off-lattice protein models. The simulation results reveal the relative stability and physical accuracy of protein models with efficient computational cost. PMID:25779670

  11. WFH: closing the global gap--achieving optimal care.

    PubMed

    Skinner, Mark W

    2012-07-01

    For 50 years, the World Federation of Hemophilia (WFH) has been working globally to close the gap in care and to achieve Treatment for All patients, men and women, with haemophilia and other inherited bleeding disorders, regardless of where they might live. The WFH estimates that more than one in 1000 men and women has a bleeding disorder equating to 6,900,000 worldwide. To close the gap in care between developed and developing nations a continued focus on the successful strategies deployed heretofore will be required. However, in response to the rapid advances in treatment and emerging therapeutic advances on the horizon it will also require fresh approaches and renewed strategic thinking. It is difficult to predict what each therapeutic advance on the horizon will mean for the future, but there is no doubt that we are in a golden age of research and development, which has the prospect of revolutionizing treatment once again. An improved understanding of "optimal" treatment is fundamental to the continued evolution of global care. The challenges of answering government and payer demands for evidence-based medicine, and cost justification for the introduction and enhancement of treatment, are ever-present and growing. To sustain and improve care it is critical to build the body of outcome data for individual patients, within haemophilia treatment centers (HTCs), nationally, regionally and globally. Emerging therapeutic advances (longer half-life therapies and gene transfer) should not be justified or brought to market based only on the notion that they will be economically more affordable, although that may be the case, but rather more importantly that they will be therapeutically more advantageous. Improvements in treatment adherence, reductions in bleeding frequency (including microhemorrhages), better management of trough levels, and improved health outcomes (including quality of life) should be the foremost considerations. As part of a new WFH strategic plan

  12. Global time optimal motions of robotic manipulators in the presence of obstacles

    NASA Technical Reports Server (NTRS)

    Shiller, Zvi; Dubowsky, Steven

    1988-01-01

    A practical method to obtain the global time optimal motions of robotic manipulators is presented. This method takes into account the nonlinear manipulator dynamics, actuator constraints, joint limits, and obstacles. Previously developed methods of optimizing manipulator motions along given paths and a local path optimization are utilized. A set of best paths is obtained first in a global search over the manipulator workspace, using graph search and hierarchical pruning techniques. These paths are used as initial conditions for a continuous path optimization to yield the global optimal motion. Examples of optimized motions of a six-degree-of-freedom manipulator, operating in a three-dimensional space with obstacles, are presented.

  13. ABCluster: the artificial bee colony algorithm for cluster global optimization.

    PubMed

    Zhang, Jun; Dolg, Michael

    2015-10-01

    Global optimization of cluster geometries is of fundamental importance in chemistry and an interesting problem in applied mathematics. In this work, we introduce a relatively new swarm intelligence algorithm, i.e. the artificial bee colony (ABC) algorithm proposed in 2005, to this field. It is inspired by the foraging behavior of a bee colony, and only three parameters are needed to control it. We applied it to several potential functions of quite different nature, i.e., the Coulomb-Born-Mayer, Lennard-Jones, Morse, Z and Gupta potentials. The benchmarks reveal that for long-ranged potentials the ABC algorithm is very efficient in locating the global minimum, while for short-ranged ones it is sometimes trapped into a local minimum funnel on a potential energy surface of large clusters. We have released an efficient, user-friendly, and free program "ABCluster" to realize the ABC algorithm. It is a black-box program for non-experts as well as experts and might become a useful tool for chemists to study clusters. PMID:26327507

  14. Geophysical Inversion With Multi-Objective Global Optimization Methods

    NASA Astrophysics Data System (ADS)

    Lelièvre, Peter; Bijani, Rodrigo; Farquharson, Colin

    2016-04-01

    We are investigating the use of Pareto multi-objective global optimization (PMOGO) methods to solve numerically complicated geophysical inverse problems. PMOGO methods can be applied to highly nonlinear inverse problems, to those where derivatives are discontinuous or simply not obtainable, and to those were multiple minima exist in the problem space. PMOGO methods generate a suite of solutions that minimize multiple objectives (e.g. data misfits and regularization terms) in a Pareto-optimal sense. This allows a more complete assessment of the possibilities and provides opportunities to calculate statistics regarding the likelihood of particular model features. We are applying PMOGO methods to four classes of inverse problems. The first are discrete-body problems where the inversion determines values of several parameters that define the location, orientation, size and physical properties of an anomalous body represented by a simple shape, for example a sphere, ellipsoid, cylinder or cuboid. A PMOGO approach can determine not only the optimal shape parameters for the anomalous body but also the optimal shape itself. Furthermore, when one expects several anomalous bodies in the subsurface, a PMOGO inversion approach can determine an optimal number of parameterized bodies. The second class of inverse problems are standard mesh-based problems where the physical property values in each cell are treated as continuous variables. The third class of problems are lithological inversions, which are also mesh-based but cells can only take discrete physical property values corresponding to known or assumed rock units. In the fourth class, surface geometry inversions, we consider a fundamentally different type of problem in which a model comprises wireframe surfaces representing contacts between rock units. The physical properties of each rock unit remain fixed while the inversion controls the position of the contact surfaces via control nodes. Surface geometry inversion can be

  15. Optimizing global liver function in radiation therapy treatment planning

    NASA Astrophysics Data System (ADS)

    Wu, Victor W.; Epelman, Marina A.; Wang, Hesheng; Romeijn, H. Edwin; Feng, Mary; Cao, Yue; Ten Haken, Randall K.; Matuszak, Martha M.

    2016-09-01

    Liver stereotactic body radiation therapy (SBRT) patients differ in both pre-treatment liver function (e.g. due to degree of cirrhosis and/or prior treatment) and radiosensitivity, leading to high variability in potential liver toxicity with similar doses. This work investigates three treatment planning optimization models that minimize risk of toxicity: two consider both voxel-based pre-treatment liver function and local-function-based radiosensitivity with dose; one considers only dose. Each model optimizes different objective functions (varying in complexity of capturing the influence of dose on liver function) subject to the same dose constraints and are tested on 2D synthesized and 3D clinical cases. The normal-liver-based objective functions are the linearized equivalent uniform dose (\\ell \\text{EUD} ) (conventional ‘\\ell \\text{EUD} model’), the so-called perfusion-weighted \\ell \\text{EUD} (\\text{fEUD} ) (proposed ‘fEUD model’), and post-treatment global liver function (GLF) (proposed ‘GLF model’), predicted by a new liver-perfusion-based dose-response model. The resulting \\ell \\text{EUD} , fEUD, and GLF plans delivering the same target \\ell \\text{EUD} are compared with respect to their post-treatment function and various dose-based metrics. Voxel-based portal venous liver perfusion, used as a measure of local function, is computed using DCE-MRI. In cases used in our experiments, the GLF plan preserves up to 4.6 % ≤ft(7.5 % \\right) more liver function than the fEUD (\\ell \\text{EUD} ) plan does in 2D cases, and up to 4.5 % ≤ft(5.6 % \\right) in 3D cases. The GLF and fEUD plans worsen in \\ell \\text{EUD} of functional liver on average by 1.0 Gy and 0.5 Gy in 2D and 3D cases, respectively. Liver perfusion information can be used during treatment planning to minimize the risk of toxicity by improving expected GLF; the degree of benefit varies with perfusion pattern. Although fEUD model optimization is computationally inexpensive and

  16. Optimizing global liver function in radiation therapy treatment planning.

    PubMed

    Wu, Victor W; Epelman, Marina A; Wang, Hesheng; Edwin Romeijn, H; Feng, Mary; Cao, Yue; Ten Haken, Randall K; Matuszak, Martha M

    2016-09-01

    Liver stereotactic body radiation therapy (SBRT) patients differ in both pre-treatment liver function (e.g. due to degree of cirrhosis and/or prior treatment) and radiosensitivity, leading to high variability in potential liver toxicity with similar doses. This work investigates three treatment planning optimization models that minimize risk of toxicity: two consider both voxel-based pre-treatment liver function and local-function-based radiosensitivity with dose; one considers only dose. Each model optimizes different objective functions (varying in complexity of capturing the influence of dose on liver function) subject to the same dose constraints and are tested on 2D synthesized and 3D clinical cases. The normal-liver-based objective functions are the linearized equivalent uniform dose ([Formula: see text]) (conventional '[Formula: see text] model'), the so-called perfusion-weighted [Formula: see text] ([Formula: see text]) (proposed 'fEUD model'), and post-treatment global liver function (GLF) (proposed 'GLF model'), predicted by a new liver-perfusion-based dose-response model. The resulting [Formula: see text], fEUD, and GLF plans delivering the same target [Formula: see text] are compared with respect to their post-treatment function and various dose-based metrics. Voxel-based portal venous liver perfusion, used as a measure of local function, is computed using DCE-MRI. In cases used in our experiments, the GLF plan preserves up to [Formula: see text] more liver function than the fEUD ([Formula: see text]) plan does in 2D cases, and up to [Formula: see text] in 3D cases. The GLF and fEUD plans worsen in [Formula: see text] of functional liver on average by 1.0 Gy and 0.5 Gy in 2D and 3D cases, respectively. Liver perfusion information can be used during treatment planning to minimize the risk of toxicity by improving expected GLF; the degree of benefit varies with perfusion pattern. Although fEUD model optimization is computationally inexpensive and often

  17. On the performance of linear decreasing inertia weight particle swarm optimization for global optimization.

    PubMed

    Arasomwan, Martins Akugbe; Adewumi, Aderemi Oluyinka

    2013-01-01

    Linear decreasing inertia weight (LDIW) strategy was introduced to improve on the performance of the original particle swarm optimization (PSO). However, linear decreasing inertia weight PSO (LDIW-PSO) algorithm is known to have the shortcoming of premature convergence in solving complex (multipeak) optimization problems due to lack of enough momentum for particles to do exploitation as the algorithm approaches its terminal point. Researchers have tried to address this shortcoming by modifying LDIW-PSO or proposing new PSO variants. Some of these variants have been claimed to outperform LDIW-PSO. The major goal of this paper is to experimentally establish the fact that LDIW-PSO is very much efficient if its parameters are properly set. First, an experiment was conducted to acquire a percentage value of the search space limits to compute the particle velocity limits in LDIW-PSO based on commonly used benchmark global optimization problems. Second, using the experimentally obtained values, five well-known benchmark optimization problems were used to show the outstanding performance of LDIW-PSO over some of its competitors which have in the past claimed superiority over it. Two other recent PSO variants with different inertia weight strategies were also compared with LDIW-PSO with the latter outperforming both in the simulation experiments conducted. PMID:24324383

  18. Global and Local Sparse Subspace Optimization for Motion Segmentation

    NASA Astrophysics Data System (ADS)

    Yang, M. Ying; Feng, S.; Ackermann, H.; Rosenhahn, B.

    2015-08-01

    In this paper, we propose a new framework for segmenting feature-based moving objects under affine subspace model. Since the feature trajectories in practice are high-dimensional and contain a lot of noise, we firstly apply the sparse PCA to represent the original trajectories with a low-dimensional global subspace, which consists of the orthogonal sparse principal vectors. Subsequently, the local subspace separation will be achieved via automatically searching the sparse representation of the nearest neighbors for each projected data. In order to refine the local subspace estimation result, we propose an error estimation to encourage the projected data that span a same local subspace to be clustered together. In the end, the segmentation of different motions is achieved through the spectral clustering on an affinity matrix, which is constructed with both the error estimation and sparse neighbors optimization. We test our method extensively and compare it with state-of-the-art methods on the Hopkins 155 dataset. The results show that our method is comparable with the other motion segmentation methods, and in many cases exceed them in terms of precision and computation time.

  19. An Improved Teaching-Learning-Based Optimization with the Social Character of PSO for Global Optimization.

    PubMed

    Zou, Feng; Chen, Debao; Wang, Jiangtao

    2016-01-01

    An improved teaching-learning-based optimization with combining of the social character of PSO (TLBO-PSO), which is considering the teacher's behavior influence on the students and the mean grade of the class, is proposed in the paper to find the global solutions of function optimization problems. In this method, the teacher phase of TLBO is modified; the new position of the individual is determined by the old position, the mean position, and the best position of current generation. The method overcomes disadvantage that the evolution of the original TLBO might stop when the mean position of students equals the position of the teacher. To decrease the computation cost of the algorithm, the process of removing the duplicate individual in original TLBO is not adopted in the improved algorithm. Moreover, the probability of local convergence of the improved method is decreased by the mutation operator. The effectiveness of the proposed method is tested on some benchmark functions, and the results are competitive with respect to some other methods. PMID:27057157

  20. An Improved Teaching-Learning-Based Optimization with the Social Character of PSO for Global Optimization

    PubMed Central

    Zou, Feng; Chen, Debao; Wang, Jiangtao

    2016-01-01

    An improved teaching-learning-based optimization with combining of the social character of PSO (TLBO-PSO), which is considering the teacher's behavior influence on the students and the mean grade of the class, is proposed in the paper to find the global solutions of function optimization problems. In this method, the teacher phase of TLBO is modified; the new position of the individual is determined by the old position, the mean position, and the best position of current generation. The method overcomes disadvantage that the evolution of the original TLBO might stop when the mean position of students equals the position of the teacher. To decrease the computation cost of the algorithm, the process of removing the duplicate individual in original TLBO is not adopted in the improved algorithm. Moreover, the probability of local convergence of the improved method is decreased by the mutation operator. The effectiveness of the proposed method is tested on some benchmark functions, and the results are competitive with respect to some other methods. PMID:27057157

  1. Global optimization of fuel consumption in rendezvous scenarios by the method of interval analysis

    NASA Astrophysics Data System (ADS)

    Ma, Hongliang; Xu, Shijie

    2015-03-01

    To reduce the optimal but large Δv of the fixed-short-time two impulse Lambert rendezvous between two spacecrafts along two coplanar circular orbits, the three-impulse Lambert rendezvous optimized via the optimization algorithm-interval analysis (IA) is proposed in this paper. The purpose of optimization is to minimize the velocity increment of the fixed-short-time three-impulse Lambert rendezvous. The optimization algorithm IA is given for solving the rendezvous optimization problem with multiple uncertain variables, and strong nonlinearity and nonconvexity. Numerical examples of the time-open, coplanar-circular-orbit, multiple-revolution Lambert rendezvous with a parking time optimized via the optimization algorithm IA are firstly undertaken to validate the feasibility of the optimization algorithm IA by comparing the optimization results with those of the globally optimal Hohmann transfer. The results indicate that the globally optimal parameters of the time-open coplanar-circular-orbit multiple-revolution Lambert rendezvous can be obtained by the optimization algorithm IA, and the initial separation angle of two spacecrafts with different orbit radius can be adjusted to obtain the globally optimal and small Δv by distributing an optimal parking time. After that, for the fixed-short-time two-impulse Lambert rendezvous problem without sufficient time to adjust the separation angle by distributing a parking time like the open-time Lambert rendezvous problem, three-impulse Lambert rendezvous involving multiple optimization variables is given and the variables are optimized by the optimization algorithm IA to obtain an optimal and small Δv. Numerical simulation indicates that the optimal and small Δv of the fixed short time, three-impulse Lambert rendezvous can be obtained using the optimization algorithm IA.

  2. Optimizing molecular properties using a relative index of thermodynamic stability and global optimization techniques.

    PubMed

    Fournier, René; Mohareb, Amir

    2016-01-14

    We devised a global optimization (GO) strategy for optimizing molecular properties with respect to both geometry and chemical composition. A relative index of thermodynamic stability (RITS) is introduced to allow meaningful energy comparisons between different chemical species. We use the RITS by itself, or in combination with another calculated property, to create an objective function F to be minimized. Including the RITS in the definition of F ensures that the solutions have some degree of thermodynamic stability. We illustrate how the GO strategy works with three test applications, with F calculated in the framework of Kohn-Sham Density Functional Theory (KS-DFT) with the Perdew-Burke-Ernzerhof exchange-correlation. First, we searched the composition and configuration space of CmHnNpOq (m = 0-4, n = 0-10, p = 0-2, q = 0-2, and 2 ≤ m + n + p + q ≤ 12) for stable molecules. The GO discovered familiar molecules like N2, CO2, acetic acid, acetonitrile, ethane, and many others, after a small number (5000) of KS-DFT energy evaluations. Second, we carried out a GO of the geometry of CumSnn (+) (m = 1, 2 and n = 9-12). A single GO run produced the same low-energy structures found in an earlier study where each CumSnn (+) species had been optimized separately. Finally, we searched bimetallic clusters AmBn (3 ≤ m + n ≤ 6, A,B= Li, Na, Al, Cu, Ag, In, Sn, Pb) for species and configurations having a low RITS and large highest occupied Molecular Orbital (MO) to lowest unoccupied MO energy gap (Eg). We found seven bimetallic clusters with Eg > 1.5 eV. PMID:26772561

  3. Optimizing molecular properties using a relative index of thermodynamic stability and global optimization techniques

    NASA Astrophysics Data System (ADS)

    Fournier, René; Mohareb, Amir

    2016-01-01

    We devised a global optimization (GO) strategy for optimizing molecular properties with respect to both geometry and chemical composition. A relative index of thermodynamic stability (RITS) is introduced to allow meaningful energy comparisons between different chemical species. We use the RITS by itself, or in combination with another calculated property, to create an objective function F to be minimized. Including the RITS in the definition of F ensures that the solutions have some degree of thermodynamic stability. We illustrate how the GO strategy works with three test applications, with F calculated in the framework of Kohn-Sham Density Functional Theory (KS-DFT) with the Perdew-Burke-Ernzerhof exchange-correlation. First, we searched the composition and configuration space of CmHnNpOq (m = 0-4, n = 0-10, p = 0-2, q = 0-2, and 2 ≤ m + n + p + q ≤ 12) for stable molecules. The GO discovered familiar molecules like N2, CO2, acetic acid, acetonitrile, ethane, and many others, after a small number (5000) of KS-DFT energy evaluations. Second, we carried out a GO of the geometry of Cu m Snn + (m = 1, 2 and n = 9-12). A single GO run produced the same low-energy structures found in an earlier study where each Cu m S nn + species had been optimized separately. Finally, we searched bimetallic clusters AmBn (3 ≤ m + n ≤ 6, A,B= Li, Na, Al, Cu, Ag, In, Sn, Pb) for species and configurations having a low RITS and large highest occupied Molecular Orbital (MO) to lowest unoccupied MO energy gap (Eg). We found seven bimetallic clusters with Eg > 1.5 eV.

  4. Global Optimization of Low-Thrust Interplanetary Trajectories Subject to Operational Constraints

    NASA Technical Reports Server (NTRS)

    Englander, Jacob A.; Vavrina, Matthew A.; Hinckley, David

    2016-01-01

    Low-thrust interplanetary space missions are highly complex and there can be many locally optimal solutions. While several techniques exist to search for globally optimal solutions to low-thrust trajectory design problems, they are typically limited to unconstrained trajectories. The operational design community in turn has largely avoided using such techniques and has primarily focused on accurate constrained local optimization combined with grid searches and intuitive design processes at the expense of efficient exploration of the global design space. This work is an attempt to bridge the gap between the global optimization and operational design communities by presenting a mathematical framework for global optimization of low-thrust trajectories subject to complex constraints including the targeting of planetary landing sites, a solar range constraint to simplify the thermal design of the spacecraft, and a real-world multi-thruster electric propulsion system that must switch thrusters on and off as available power changes over the course of a mission.

  5. Nonlinear Global Optimization Using Curdling Algorithm in Mathematica Environmet

    Energy Science and Technology Software Center (ESTSC)

    1997-08-05

    An algorithm for performing optimization which is a derivative-free, grid-refinement approach to nonlinear optimization was developed and implemented in software as OPTIMIZE. This approach overcomes a number of deficiencies in existing approaches. Most notably, it finds extremal regions rather than only single extremal points. the program is interactive and collects information on control parameters and constraints using menus. For up to two (and potentially three) dimensions, function convergence is displayed graphically. Because the algorithm doesmore » not compute derivatives, gradients, or vectors, it is numerically stable. It can find all the roots of a polynomial in one pass. It is an inherently parallel algorithm. OPTIMIZE-M is a modification of OPTIMIZE designed for use within the Mathematica environment created by Wolfram Research.« less

  6. New Tabu Search based global optimization methods outline of algorithms and study of efficiency.

    PubMed

    Stepanenko, Svetlana; Engels, Bernd

    2008-04-15

    The study presents two new nonlinear global optimization routines; the Gradient Only Tabu Search (GOTS) and the Tabu Search with Powell's Algorithm (TSPA). They are based on the Tabu-Search strategy, which tries to determine the global minimum of a function by the steepest descent-mildest ascent strategy. The new algorithms are explained and their efficiency is compared with other approaches by determining the global minima of various well-known test functions with varying dimensionality. These tests show that for most tests the GOTS possesses a much faster convergence than global optimizer taken from the literature. The efficiency of the TSPA compares to the efficiency of genetic algorithms. PMID:17910004

  7. Optimization of cascade blade mistuning. II - Global optimum and numerical optimization

    NASA Technical Reports Server (NTRS)

    Nissim, E.; Haftka, R. T.

    1985-01-01

    The values of the mistuning which yield the most stable eigenvectors are analytically determined, using the simplified equations of motion which were developed in Part I of this work. It is shown that random mistunings, if large enough, may lead to the maximal stability, whereas the alternate mistunings cannot. The problem of obtaining maximum stability for minimal mistuning is formulated, based on numerical optimization techniques. Several local minima are obtained using different starting mistuning vectors. The starting vectors which lead to the global minimum are identified. It is analytically shown that all minima appear in multiplicities which are equal to the number of compressor blades. The effect of mistuning on the flutter speed is studied using both an optimum mistuning vector and an alternate mistuning vector. Effects of mistunings in elastic axis locations are shown to have a negligible effect on the eigenvalues. Finally, it is shown that any general two-dimensional bending-torsion system can be reduced to an equivalent uncoupled torsional system.

  8. Optimal Detection of Global Warming using Temperature Profiles

    NASA Technical Reports Server (NTRS)

    Leroy, Stephen S.

    1997-01-01

    Optimal fingerprinting is applied to estimate the amount of time it would take to detect warming by increased concentrations of carbon dioxide in monthly averages of temperature profiles over the Indian Ocean.

  9. On a global aerodynamic optimization of a civil transport aircraft

    NASA Technical Reports Server (NTRS)

    Savu, G.; Trifu, O.

    1991-01-01

    An aerodynamic optimization procedure developed to minimize the drag to lift ratio of an aircraft configuration: wing - body - tail, in accordance with engineering restrictions, is described. An algorithm developed to search a hypersurface with 18 dimensions, which define an aircraft configuration, is discussed. The results, when considered from the aerodynamic point of view, indicate the optimal configuration is one that combines a lifting fuselage with a canard.

  10. Global Optimization Using Mixed Surrogates and Space Elimination in Computationally Intensive Engineering Designs

    NASA Astrophysics Data System (ADS)

    Younis, Adel; Dong, Zuomin

    2012-07-01

    Surrogate-based modeling is an effective search method for global design optimization over well-defined areas using complex and computationally intensive analysis and simulation tools. However, indentifying the appreciate surrogate models and their suitable areas remains a challenge that requires extensive human intervention. In this work, a new global optimization algorithm, namely Mixed Surrogate and Space Elimination (MSSE) method, is introduced. Representative surrogate models, including Quadratic Response Surface, Radial Basis function, and Kriging, are mixed with different weight ratios to form an adaptive metamodel with best tested performance. The approach divides the field of interest into several unimodal regions; identifies and ranks the regions that likely contain the global minimum; fits the weighted surrogate models over each promising region using additional design experiment data points from Latin Hypercube Designs and adjusts the weights according to the performance of each model; identifies its minimum and removes the processed region; and moves to the next most promising region until all regions are processed and the global optimum is identified. The proposed algorithm was tested using several benchmark problems for global optimization and compared with several widely used space exploration global optimization algorithms, showing reduced computation efforts, robust performance and comparable search accuracy, making the proposed method an excellent tool for computationally intensive global design optimization problems.

  11. The Tunneling Method for Global Optimization in Multidimensional Scaling.

    ERIC Educational Resources Information Center

    Groenen, Patrick J. F.; Heiser, Willem J.

    1996-01-01

    A tunneling method for global minimization in multidimensional scaling is introduced and adjusted for multidimensional scaling with general Minkowski distances. The method alternates a local search step with a tunneling step in which a different configuration is sought with the same STRESS implementation. (SLD)

  12. Global stability and optimal control of an SIRS epidemic model on heterogeneous networks

    NASA Astrophysics Data System (ADS)

    Chen, Lijuan; Sun, Jitao

    2014-09-01

    In this paper, we consider an SIRS epidemic model with vaccination on heterogeneous networks. By constructing suitable Lyapunov functions, global stability of the disease-free equilibrium and the endemic equilibrium of the model is investigated. Also we firstly study an optimally controlled SIRS epidemic model on complex networks. We show that an optimal control exists for the control problem. Finally some examples are presented to show the global stability and the efficiency of this optimal control. These results can help in adopting pragmatic treatment upon diseases in structured populations.

  13. Quadruped Robot Locomotion using a Global Optimization Stochastic Algorithm

    NASA Astrophysics Data System (ADS)

    Oliveira, Miguel; Santos, Cristina; Costa, Lino; Ferreira, Manuel

    2011-09-01

    The problem of tuning nonlinear dynamical systems parameters, such that the attained results are considered good ones, is a relevant one. This article describes the development of a gait optimization system that allows a fast but stable robot quadruped crawl gait. We combine bio-inspired Central Patterns Generators (CPGs) and Genetic Algorithms (GA). CPGs are modelled as autonomous differential equations, that generate the necessar y limb movement to perform the required walking gait. The GA finds parameterizations of the CPGs parameters which attain good gaits in terms of speed, vibration and stability. Moreover, two constraint handling techniques based on tournament selection and repairing mechanism are embedded in the GA to solve the proposed constrained optimization problem and make the search more efficient. The experimental results, performed on a simulated Aibo robot, demonstrate that our approach allows low vibration with a high velocity and wide stability margin for a quadruped slow crawl gait.

  14. A reconciliation of local and global models for bone remodeling through optimization theory.

    PubMed

    Subbarayan, G; Bartel, D L

    2000-02-01

    Remodeling rules with either a global or a local mathematical form have been proposed for load-bearing bones in the literature. In the local models, the bone architecture (shape, density) is related to the strains/energies sensed at any point in the bone, while in the global models, a criterion believed to be applicable to the whole bone is used. In the present paper, a local remodeling rule with a strain "error" form is derived as the necessary condition for the optimum of a global remodeling criterion, suggesting that many of the local error-driven remodeling rules may have corresponding global optimization-based criteria. The global criterion proposed in the present study is a trade-off between the cost of metabolic growth and use, mathematically represented by the mass, and the cost of failure, mathematically represented by the total strain energy. The proposed global criterion is shown to be related to the optimality criteria methods of structural optimization by the equivalence of the model solution and the fully stressed solution for statically determinate structures. In related work, the global criterion is applied to simulate the strength recovery in bones with screw holes left behind after removal of fracture fixation plates. The results predicted by the model are shown to be in good agreement with experimental results, leading to the conclusion that load-bearing bones are structures with optimal shape and property for their function. PMID:10790832

  15. Optimal Estimates of Global Terrestrial GPP from Fluorescence and DGVMs

    NASA Astrophysics Data System (ADS)

    Parazoo, Nicholas; Bowman, Kevin; Fisher, Joshua; Frankenberg, Christian; Jones, Dylan; Cescatti, Alessandro; Perez-Priego, Oscar; Wohlfahrt, Georg; Montagnani, Leonardo

    2014-05-01

    Changes in the processes that control terrestrial carbon uptake are highly uncertain but likely to have a significant influence on future atmospheric CO2 levels. RECCAP aims to improve process understanding by reconciling fluxes from top-down CO2 inversions and bottom-up estimates from an ensemble of DGVMs. As these models are typically used in projections of climate change a key part of this effort is benchmarking models and evaluating drivers of net carbon exchange within the current climate. Of particular importance are the spatial distribution and time rate of change of GPP. Recent advances in the remote sensing of solar-induced chlorophyll fluorescence opens up a new possibility to directly measure planetary photosynthesis on spatially resolved scales. Here, we discuss a new methodology for estimating GPP and uncertainty from an optimal combination of an ensemble of DGVMs from the TRENDY project with satellite-based fluorescence observations from GOSAT. Prior uncertainty is estimated from the spread of DGVMs and updated through assimilation of fluorescence. We evaluate optimized fluxes against flux tower data in N. America, Europe, and S. America, benchmark TRENDY models using updated uncertainty estimates, and examine changes in the structure of the seasonal cycle. We find this methodology provides a novel way to evaluate models used in climate projections.

  16. A Global Optimization Methodology for Rocket Propulsion Applications

    NASA Technical Reports Server (NTRS)

    2001-01-01

    While the response surface method is an effective method in engineering optimization, its accuracy is often affected by the use of limited amount of data points for model construction. In this chapter, the issues related to the accuracy of the RS approximations and possible ways of improving the RS model using appropriate treatments, including the iteratively re-weighted least square (IRLS) technique and the radial-basis neural networks, are investigated. A main interest is to identify ways to offer added capabilities for the RS method to be able to at least selectively improve the accuracy in regions of importance. An example is to target the high efficiency region of a fluid machinery design space so that the predictive power of the RS can be maximized when it matters most. Analytical models based on polynomials, with controlled level of noise, are used to assess the performance of these techniques.

  17. Chaos optimization algorithms based on chaotic maps with different probability distribution and search speed for global optimization

    NASA Astrophysics Data System (ADS)

    Yang, Dixiong; Liu, Zhenjun; Zhou, Jilei

    2014-04-01

    Chaos optimization algorithms (COAs) usually utilize the chaotic map like Logistic map to generate the pseudo-random numbers mapped as the design variables for global optimization. Many existing researches indicated that COA can more easily escape from the local minima than classical stochastic optimization algorithms. This paper reveals the inherent mechanism of high efficiency and superior performance of COA, from a new perspective of both the probability distribution property and search speed of chaotic sequences generated by different chaotic maps. The statistical property and search speed of chaotic sequences are represented by the probability density function (PDF) and the Lyapunov exponent, respectively. Meanwhile, the computational performances of hybrid chaos-BFGS algorithms based on eight one-dimensional chaotic maps with different PDF and Lyapunov exponents are compared, in which BFGS is a quasi-Newton method for local optimization. Moreover, several multimodal benchmark examples illustrate that, the probability distribution property and search speed of chaotic sequences from different chaotic maps significantly affect the global searching capability and optimization efficiency of COA. To achieve the high efficiency of COA, it is recommended to adopt the appropriate chaotic map generating the desired chaotic sequences with uniform or nearly uniform probability distribution and large Lyapunov exponent.

  18. A Guiding Evolutionary Algorithm with Greedy Strategy for Global Optimization Problems

    PubMed Central

    Cao, Leilei; Xu, Lihong; Goodman, Erik D.

    2016-01-01

    A Guiding Evolutionary Algorithm (GEA) with greedy strategy for global optimization problems is proposed. Inspired by Particle Swarm Optimization, the Genetic Algorithm, and the Bat Algorithm, the GEA was designed to retain some advantages of each method while avoiding some disadvantages. In contrast to the usual Genetic Algorithm, each individual in GEA is crossed with the current global best one instead of a randomly selected individual. The current best individual served as a guide to attract offspring to its region of genotype space. Mutation was added to offspring according to a dynamic mutation probability. To increase the capability of exploitation, a local search mechanism was applied to new individuals according to a dynamic probability of local search. Experimental results show that GEA outperformed the other three typical global optimization algorithms with which it was compared. PMID:27293421

  19. A Guiding Evolutionary Algorithm with Greedy Strategy for Global Optimization Problems.

    PubMed

    Cao, Leilei; Xu, Lihong; Goodman, Erik D

    2016-01-01

    A Guiding Evolutionary Algorithm (GEA) with greedy strategy for global optimization problems is proposed. Inspired by Particle Swarm Optimization, the Genetic Algorithm, and the Bat Algorithm, the GEA was designed to retain some advantages of each method while avoiding some disadvantages. In contrast to the usual Genetic Algorithm, each individual in GEA is crossed with the current global best one instead of a randomly selected individual. The current best individual served as a guide to attract offspring to its region of genotype space. Mutation was added to offspring according to a dynamic mutation probability. To increase the capability of exploitation, a local search mechanism was applied to new individuals according to a dynamic probability of local search. Experimental results show that GEA outperformed the other three typical global optimization algorithms with which it was compared. PMID:27293421

  20. Method for using global optimization to the estimation of surface-consistent residual statics

    DOEpatents

    Reister, David B.; Barhen, Jacob; Oblow, Edward M.

    2001-01-01

    An efficient method for generating residual statics corrections to compensate for surface-consistent static time shifts in stacked seismic traces. The method includes a step of framing the residual static corrections as a global optimization problem in a parameter space. The method also includes decoupling the global optimization problem involving all seismic traces into several one-dimensional problems. The method further utilizes a Stochastic Pijavskij Tunneling search to eliminate regions in the parameter space where a global minimum is unlikely to exist so that the global minimum may be quickly discovered. The method finds the residual statics corrections by maximizing the total stack power. The stack power is a measure of seismic energy transferred from energy sources to receivers.

  1. Global and Local Optimization Methods for Calibration and Design of Computationally Expensive Hydrologic Models

    NASA Astrophysics Data System (ADS)

    Shoemaker, C. A.; Singh, A.

    2008-12-01

    This paper will describe some new optimization algorithms and their application to hydrologic models. The approaches include a parallel version of a new heuristic algorithm combined with tabu search and a mathematically derived global optimization method that is based on trust region methods. The goals of these methods are to find optimal solutions to calibration problems and to design problems with relatively few simulations or (in a parallel environment) relatively little wallclock time. This is important because currently it is not possible to apply global optimization methods like genetic algorithms to computationally expensive simulation models like partial differential equations (with many nodes in groundwater) because it is not feasible to do thousands of simulations to evaluate the objective/fitness function. Results of the application of the algorithms to some complex models of groundwater contamination and phosphorous transport in watersheds will be presented.

  2. Optimization of global model composed of radial basis functions using the term-ranking approach

    SciTech Connect

    Cai, Peng; Tao, Chao Liu, Xiao-Jun

    2014-03-15

    A term-ranking method is put forward to optimize the global model composed of radial basis functions to improve the predictability of the model. The effectiveness of the proposed method is examined by numerical simulation and experimental data. Numerical simulations indicate that this method can significantly lengthen the prediction time and decrease the Bayesian information criterion of the model. The application to real voice signal shows that the optimized global model can capture more predictable component in chaos-like voice data and simultaneously reduce the predictable component (periodic pitch) in the residual signal.

  3. An adaptive metamodel-based global optimization algorithm for black-box type problems

    NASA Astrophysics Data System (ADS)

    Jie, Haoxiang; Wu, Yizhong; Ding, Jianwan

    2015-11-01

    In this article, an adaptive metamodel-based global optimization (AMGO) algorithm is presented to solve unconstrained black-box problems. In the AMGO algorithm, a type of hybrid model composed of kriging and augmented radial basis function (RBF) is used as the surrogate model. The weight factors of hybrid model are adaptively selected in the optimization process. To balance the local and global search, a sub-optimization problem is constructed during each iteration to determine the new iterative points. As numerical experiments, six standard two-dimensional test functions are selected to show the distributions of iterative points. The AMGO algorithm is also tested on seven well-known benchmark optimization problems and contrasted with three representative metamodel-based optimization methods: efficient global optimization (EGO), GutmannRBF and hybrid and adaptive metamodel (HAM). The test results demonstrate the efficiency and robustness of the proposed method. The AMGO algorithm is finally applied to the structural design of the import and export chamber of a cycloid gear pump, achieving satisfactory results.

  4. Autonomous Modelling of X-ray Spectra Using Robust Global Optimization Methods

    NASA Astrophysics Data System (ADS)

    Rogers, Adam; Safi-Harb, Samar; Fiege, Jason

    2015-08-01

    The standard approach to model fitting in X-ray astronomy is by means of local optimization methods. However, these local optimizers suffer from a number of problems, such as a tendency for the fit parameters to become trapped in local minima, and can require an involved process of detailed user intervention to guide them through the optimization process. In this work we introduce a general GUI-driven global optimization method for fitting models to X-ray data, written in MATLAB, which searches for optimal models with minimal user interaction. We directly interface with the commonly used XSPEC libraries to access the full complement of pre-existing spectral models that describe a wide range of physics appropriate for modelling astrophysical sources, including supernova remnants and compact objects. Our algorithm is powered by the Ferret genetic algorithm and Locust particle swarm optimizer from the Qubist Global Optimization Toolbox, which are robust at finding families of solutions and identifying degeneracies. This technique will be particularly instrumental for multi-parameter models and high-fidelity data. In this presentation, we provide details of the code and use our techniques to analyze X-ray data obtained from a variety of astrophysical sources.

  5. Fast Gaussian kernel learning for classification tasks based on specially structured global optimization.

    PubMed

    Zhong, Shangping; Chen, Tianshun; He, Fengying; Niu, Yuzhen

    2014-09-01

    For a practical pattern classification task solved by kernel methods, the computing time is mainly spent on kernel learning (or training). However, the current kernel learning approaches are based on local optimization techniques, and hard to have good time performances, especially for large datasets. Thus the existing algorithms cannot be easily extended to large-scale tasks. In this paper, we present a fast Gaussian kernel learning method by solving a specially structured global optimization (SSGO) problem. We optimize the Gaussian kernel function by using the formulated kernel target alignment criterion, which is a difference of increasing (d.i.) functions. Through using a power-transformation based convexification method, the objective criterion can be represented as a difference of convex (d.c.) functions with a fixed power-transformation parameter. And the objective programming problem can then be converted to a SSGO problem: globally minimizing a concave function over a convex set. The SSGO problem is classical and has good solvability. Thus, to find the global optimal solution efficiently, we can adopt the improved Hoffman's outer approximation method, which need not repeat the searching procedure with different starting points to locate the best local minimum. Also, the proposed method can be proven to converge to the global solution for any classification task. We evaluate the proposed method on twenty benchmark datasets, and compare it with four other Gaussian kernel learning methods. Experimental results show that the proposed method stably achieves both good time-efficiency performance and good classification performance. PMID:24929345

  6. A comparison of two global optimization algorithms with sequential niche technique for structural model updating

    NASA Astrophysics Data System (ADS)

    Shabbir, Faisal; Omenzetter, Piotr

    2014-04-01

    Much effort is devoted nowadays to derive accurate finite element (FE) models to be used for structural health monitoring, damage detection and assessment. However, formation of a FE model representative of the original structure is a difficult task. Model updating is a branch of optimization which calibrates the FE model by comparing the modal properties of the actual structure with these of the FE predictions. As the number of experimental measurements is usually much smaller than the number of uncertain parameters, and, consequently, not all uncertain parameters are selected for model updating, different local minima may exist in the solution space. Experimental noise further exacerbates the problem. The attainment of a global solution in a multi-dimensional search space is a challenging problem. Global optimization algorithms (GOAs) have received interest in the previous decade to solve this problem, but no GOA can ensure the detection of the global minimum either. To counter this problem, a combination of GOA with sequential niche technique (SNT) has been proposed in this research which systematically searches the whole solution space. A dynamically tested full scale pedestrian bridge is taken as a case study. Two different GOAs, namely particle swarm optimization (PSO) and genetic algorithm (GA), are investigated in combination with SNT. The results of these GOA are compared in terms of their efficiency in detecting global minima. The systematic search enables to find different solutions in the search space, thus increasing the confidence of finding the global minimum.

  7. On computing the global time-optimal motions of robotic manipulators in the presence of obstacles

    NASA Technical Reports Server (NTRS)

    Shiller, Zvi; Dubowsky, Steven

    1991-01-01

    A method for computing the time-optimal motions of robotic manipulators is presented that considers the nonlinear manipulator dynamics, actuator constraints, joint limits, and obstacles. The optimization problem is reduced to a search for the time-optimal path in the n-dimensional position space. A small set of near-optimal paths is first efficiently selected from a grid, using a branch and bound search and a series of lower bound estimates on the traveling time along a given path. These paths are further optimized with a local path optimization to yield the global optimal solution. Obstacles are considered by eliminating the collision points from the tessellated space and by adding a penalty function to the motion time in the local optimization. The computational efficiency of the method stems from the reduced dimensionality of the searched spaced and from combining the grid search with a local optimization. The method is demonstrated in several examples for two- and six-degree-of-freedom manipulators with obstacles.

  8. Optimal Design of Grid-Stiffened Composite Panels Using Global and Local Buckling Analysis

    SciTech Connect

    Ambur, D.R.; Jaunky, N.; Knight, N.F. Jr.

    1996-04-01

    A design strategy for optimal design of composite grid-stiffened panels subjected to global and local buckling constraints is developed using a discrete optimizer. An improved smeared stiffener theory is used for the global buckling analysis. Local buckling of skin segments is assessed using a Rayleigh-Ritz method that accounts for material anisotropy and transverse shear flexibility. The local buckling of stiffener segments is also assessed. Design variables are the axial and transverse stiffener spacing, stiffener height and thickness, skin laminate, and stiffening configuration. The design optimization process is adapted to identify the lightest-weight stiffening configuration and pattern for grid stiffened composite panels given the overall panel dimensions, design in-plane loads, material properties, and boundary conditions of the grid-stiffened panel.

  9. Optimal Design of Grid-Stiffened Composite Panels Using Global and Local Buckling Analysis

    NASA Technical Reports Server (NTRS)

    Ambur, Damodar R.; Jaunky, Navin; Knight, Norman F., Jr.

    1996-01-01

    A design strategy for optimal design of composite grid-stiffened panels subjected to global and local buckling constraints is developed using a discrete optimizer. An improved smeared stiffener theory is used for the global buckling analysis. Local buckling of skin segments is assessed using a Rayleigh-Ritz method that accounts for material anisotropy and transverse shear flexibility. The local buckling of stiffener segments is also assessed. Design variables are the axial and transverse stiffener spacing, stiffener height and thickness, skin laminate, and stiffening configuration. The design optimization process is adapted to identify the lightest-weight stiffening configuration and pattern for grid stiffened composite panels given the overall panel dimensions, design in-plane loads, material properties, and boundary conditions of the grid-stiffened panel.

  10. Isolated particle swarm optimization with particle migration and global best adoption

    NASA Astrophysics Data System (ADS)

    Tsai, Hsing-Chih; Tyan, Yaw-Yauan; Wu, Yun-Wu; Lin, Yong-Huang

    2012-12-01

    Isolated particle swarm optimization (IPSO) segregates particles into several sub-swarms in order to improve the ability of the global optimization. In this study, particle migration and global best adoption (gbest adoption) are used to improve IPSO. Particle migration allows particles to travel among sub-swarms, based on the fitness of the sub-swarms. The use of gbest adoption allows sub-swarms to peep at the gbest proportionally or probably after a certain number of iterations, i.e. gbest replacing, and gbest sharing, respectively. Three well-known benchmark functions are utilized to determine the parameter settings of the IPSO. Then, 13 benchmark functions are used to study the performance of the designed IPSO. Computational experience demonstrates that the designed IPSO is superior to the original version of particle swarm optimization (PSO) in terms of the accuracy and stability of the results, when isolation phenomenon, particle migration and gbest sharing are involved.

  11. Chaotic Teaching-Learning-Based Optimization with Lévy Flight for Global Numerical Optimization.

    PubMed

    He, Xiangzhu; Huang, Jida; Rao, Yunqing; Gao, Liang

    2016-01-01

    Recently, teaching-learning-based optimization (TLBO), as one of the emerging nature-inspired heuristic algorithms, has attracted increasing attention. In order to enhance its convergence rate and prevent it from getting stuck in local optima, a novel metaheuristic has been developed in this paper, where particular characteristics of the chaos mechanism and Lévy flight are introduced to the basic framework of TLBO. The new algorithm is tested on several large-scale nonlinear benchmark functions with different characteristics and compared with other methods. Experimental results show that the proposed algorithm outperforms other algorithms and achieves a satisfactory improvement over TLBO. PMID:26941785

  12. Chaotic Teaching-Learning-Based Optimization with Lévy Flight for Global Numerical Optimization

    PubMed Central

    He, Xiangzhu; Huang, Jida; Rao, Yunqing; Gao, Liang

    2016-01-01

    Recently, teaching-learning-based optimization (TLBO), as one of the emerging nature-inspired heuristic algorithms, has attracted increasing attention. In order to enhance its convergence rate and prevent it from getting stuck in local optima, a novel metaheuristic has been developed in this paper, where particular characteristics of the chaos mechanism and Lévy flight are introduced to the basic framework of TLBO. The new algorithm is tested on several large-scale nonlinear benchmark functions with different characteristics and compared with other methods. Experimental results show that the proposed algorithm outperforms other algorithms and achieves a satisfactory improvement over TLBO. PMID:26941785

  13. A comparative study of expected improvement-assisted global optimization with different surrogates

    NASA Astrophysics Data System (ADS)

    Wang, Hu; Ye, Fan; Li, Enying; Li, Guangyao

    2016-08-01

    Efficient global optimization (EGO) uses the surrogate uncertainty estimator called expected improvement (EI) to guide the selection of the next sampling candidates. Theoretically, any modelling methods can be integrated with the EI criterion. To improve the convergence ratio, a multi-surrogate efficient global optimization (MSEGO) was suggested. In practice, the EI-based optimization methods with different surrogates show widely divergent characteristics. Therefore, it is important to choose the most suitable algorithm for a certain problem. For this purpose, four single-surrogate efficient global optimizations (SSEGOs) and an MSEGO involving four surrogates are investigated. According to numerical tests, both the SSEGOs and the MSEGO are feasible for weak nonlinear problems. However, they are not robust for strong nonlinear problems, especially for multimodal and high-dimensional problems. Moreover, to investigate the feasibility of EGO in practice, a material identification benchmark is designed to demonstrate the performance of EGO methods. According to the tests in this study, the kriging EGO is generally the most robust method.

  14. A Modified Differential Evolution Algorithm with Cauchy Mutation for Global Optimization

    NASA Astrophysics Data System (ADS)

    Ali, Musrrat; Pant, Millie; Singh, Ved Pal

    Differential Evolution (DE) is a powerful yet simple evolutionary algorithm for optimization of real valued, multi modal functions. DE is generally considered as a reliable, accurate and robust optimization technique. However, the algorithm suffers from premature convergence, slow convergence rate and large computational time for optimizing the computationally expensive objective functions. Therefore, an attempt to speed up DE is considered necessary. This research introduces a modified differential evolution (MDE), a modification to DE that enhances the convergence rate without compromising with the solution quality. In Modified differential evolution (MDE) algorithm, if an individual fails in continuation to improve its performance to a specified number of times then new point is generated using Cauchy mutation. MDE on a test bed of functions is compared with original DE. It is found that MDE requires less computational effort to locate global optimal solution.

  15. Efficient algorithms for multidimensional global optimization in genetic mapping of complex traits

    PubMed Central

    Ljungberg, Kajsa; Mishchenko, Kateryna; Holmgren, Sverker

    2010-01-01

    We present a two-phase strategy for optimizing a multidimensional, nonconvex function arising during genetic mapping of quantitative traits. Such traits are believed to be affected by multiple so called quantitative trait loci (QTL), and searching for d QTL results in a d-dimensional optimization problem with a large number of local optima. We combine the global algorithm DIRECT with a number of local optimization methods that accelerate the final convergence, and adapt the algorithms to problem-specific features. We also improve the evaluation of the QTL mapping objective function to enable exploitation of the smoothness properties of the optimization landscape. Our best two-phase method is demonstrated to be accurate in at least six dimensions and up to ten times faster than currently used QTL mapping algorithms. PMID:21918629

  16. Double global optimum genetic algorithm-particle swarm optimization-based welding robot path planning

    NASA Astrophysics Data System (ADS)

    Wang, Xuewu; Shi, Yingpan; Ding, Dongyan; Gu, Xingsheng

    2016-02-01

    Spot-welding robots have a wide range of applications in manufacturing industries. There are usually many weld joints in a welding task, and a reasonable welding path to traverse these weld joints has a significant impact on welding efficiency. Traditional manual path planning techniques can handle a few weld joints effectively, but when the number of weld joints is large, it is difficult to obtain the optimal path. The traditional manual path planning method is also time consuming and inefficient, and cannot guarantee optimality. Double global optimum genetic algorithm-particle swarm optimization (GA-PSO) based on the GA and PSO algorithms is proposed to solve the welding robot path planning problem, where the shortest collision-free paths are used as the criteria to optimize the welding path. Besides algorithm effectiveness analysis and verification, the simulation results indicate that the algorithm has strong searching ability and practicality, and is suitable for welding robot path planning.

  17. Orbit optimization of Chang'E-2 by global adjustment using images of the moon

    NASA Astrophysics Data System (ADS)

    Yan, Wei; Liu, Jianjun; Ren, Xin; Wang, Fenfei; Wang, Wenrui; Li, Chunlai

    2015-12-01

    The orbit accuracy of the Chang'E-2 (CE-2) lunar probe is one of the most critical factors for a seamless mosaic of the global lunar topographic map. During the production of the CE-2 global lunar topographic map, a maximum deviation of kilometers magnitude existed in the horizontal direction of homologous points between neighboring images, while the maximum height deviation of these points is up to several hundred meters. This phenomenon indicates that current orbit determination results of CE-2 cannot truly reflect the relative position relationship between probe and lunar surface features. Against this background, global adjustment using images of the moon should be carried out to solve this problem. In this paper, the influence of CE-2 current orbit accuracy on the production of a global lunar topographic map will be analyzed based on the introduction of CE-2 observation data, including images and orbit data. Additionally, key technologies and technical processes of global adjustment using CE-2 images with high-resolution and large amounts of data will be researched. Finally, orbit optimization of CE-2 after global adjustment is analyzed, as well as the accuracy of the CE-2 global lunar topographic map for validation verification.

  18. Global Optimization of Interplanetary Trajectories in the Presence of Realistic Mission Contraints

    NASA Technical Reports Server (NTRS)

    Hinckley, David, Jr.; Englander, Jacob; Hitt, Darren

    2015-01-01

    Interplanetary missions are often subject to difficult constraints, like solar phase angle upon arrival at the destination, velocity at arrival, and altitudes for flybys. Preliminary design of such missions is often conducted by solving the unconstrained problem and then filtering away solutions which do not naturally satisfy the constraints. However this can bias the search into non-advantageous regions of the solution space, so it can be better to conduct preliminary design with the full set of constraints imposed. In this work two stochastic global search methods are developed which are well suited to the constrained global interplanetary trajectory optimization problem.

  19. A hybrid approach using chaotic dynamics and global search algorithms for combinatorial optimization problems

    NASA Astrophysics Data System (ADS)

    Igeta, Hideki; Hasegawa, Mikio

    Chaotic dynamics have been effectively applied to improve various heuristic algorithms for combinatorial optimization problems in many studies. Currently, the most used chaotic optimization scheme is to drive heuristic solution search algorithms applicable to large-scale problems by chaotic neurodynamics including the tabu effect of the tabu search. Alternatively, meta-heuristic algorithms are used for combinatorial optimization by combining a neighboring solution search algorithm, such as tabu, gradient, or other search method, with a global search algorithm, such as genetic algorithms (GA), ant colony optimization (ACO), or others. In these hybrid approaches, the ACO has effectively optimized the solution of many benchmark problems in the quadratic assignment problem library. In this paper, we propose a novel hybrid method that combines the effective chaotic search algorithm that has better performance than the tabu search and global search algorithms such as ACO and GA. Our results show that the proposed chaotic hybrid algorithm has better performance than the conventional chaotic search and conventional hybrid algorithms. In addition, we show that chaotic search algorithm combined with ACO has better performance than when combined with GA.

  20. Efficient global optimization applied to wind tunnel evaluation-based optimization for improvement of flow control by plasma actuators

    NASA Astrophysics Data System (ADS)

    Kanazaki, Masahiro; Matsuno, Takashi; Maeda, Kengo; Kawazoe, Hiromitsu

    2015-09-01

    A kriging-based genetic algorithm called efficient global optimization (EGO) was employed to optimize the parameters for the operating conditions of plasma actuators. The aerodynamic performance was evaluated by wind tunnel testing to overcome the disadvantages of time-consuming numerical simulations. The proposed system was used on two design problems to design the power supply for a plasma actuator. The first case was the drag minimization problem around a semicircular cylinder. In this case, the inhibitory effect of flow separation was also observed. The second case was the lift maximization problem around a circular cylinder. This case was similar to the aerofoil design, because the circular cylinder has potential to work as an aerofoil owing to the control of the flow circulation by the plasma actuators with four design parameters. In this case, applicability to the multi-variant design problem was also investigated. Based on these results, optimum designs and global design information were obtained while drastically reducing the number of experiments required compared to a full factorial experiment.

  1. Lens Design: An Attempt to Use `Escape Function' as a Tool in Global Optimization

    NASA Astrophysics Data System (ADS)

    Isshiki, Masaki; Ono, Hiroki; Nakadate, Suezou

    1995-01-01

    In designing lenses with the damped least squares method, the solution obtained by optimization routine is a local minimum of the merit function. To get out of this and seek a different solution, we propose to use an ‘escape function’ as an additional operand of the lens system, to be controlled. Experiments were made on simple models of merit function and the advantage of this technique was ascertained. We also planted this algorithm into OSLO SIX (lens design software by Sinclair Optics) by means of CCL (C-compatible language) and applied it to actual lens design. Experiments convinced us that the method would be an effective tool for global optimization.

  2. The fully actuated traffic control problem solved by global optimization and complementarity

    NASA Astrophysics Data System (ADS)

    Ribeiro, Isabel M.; de Lurdes de Oliveira Simões, Maria

    2016-02-01

    Global optimization and complementarity are used to determine the signal timing for fully actuated traffic control, regarding effective green and red times on each cycle. The average values of these parameters can be used to estimate the control delay of vehicles. In this article, a two-phase queuing system for a signalized intersection is outlined, based on the principle of minimization of the total waiting time for the vehicles. The underlying model results in a linear program with linear complementarity constraints, solved by a sequential complementarity algorithm. Departure rates of vehicles during green and yellow periods were treated as deterministic, while arrival rates of vehicles were assumed to follow a Poisson distribution. Several traffic scenarios were created and solved. The numerical results reveal that it is possible to use global optimization and complementarity over a reasonable number of cycles and determine with efficiency effective green and red times for a signalized intersection.

  3. Multi-modulus algorithm based on global artificial fish swarm intelligent optimization of DNA encoding sequences.

    PubMed

    Guo, Y C; Wang, H; Wu, H P; Zhang, M Q

    2015-01-01

    Aimed to address the defects of the large mean square error (MSE), and the slow convergence speed in equalizing the multi-modulus signals of the constant modulus algorithm (CMA), a multi-modulus algorithm (MMA) based on global artificial fish swarm (GAFS) intelligent optimization of DNA encoding sequences (GAFS-DNA-MMA) was proposed. To improve the convergence rate and reduce the MSE, this proposed algorithm adopted an encoding method based on DNA nucleotide chains to provide a possible solution to the problem. Furthermore, the GAFS algorithm, with its fast convergence and global search ability, was used to find the best sequence. The real and imaginary parts of the initial optimal weight vector of MMA were obtained through DNA coding of the best sequence. The simulation results show that the proposed algorithm has a faster convergence speed and smaller MSE in comparison with the CMA, the MMA, and the AFS-DNA-MMA. PMID:26782395

  4. Multifactorial global search algorithm in the problem of optimizing a reactive force field

    NASA Astrophysics Data System (ADS)

    Stepanova, M. M.; Shefov, K. S.; Slavyanov, S. Yu.

    2016-04-01

    We present a new multifactorial global search algorithm ( MGSA) and check the operability of the algorithm on the Michalewicz and Rastrigin functions. We discuss the choice of an objective function and additional search criteria in the context of the problem of reactive force field ( ReaxFF) optimization and study the ranking of the ReaxFF parameters together with their impact on the objective function.

  5. Ringed Seal Search for Global Optimization via a Sensitive Search Model.

    PubMed

    Saadi, Younes; Yanto, Iwan Tri Riyadi; Herawan, Tutut; Balakrishnan, Vimala; Chiroma, Haruna; Risnumawan, Anhar

    2016-01-01

    The efficiency of a metaheuristic algorithm for global optimization is based on its ability to search and find the global optimum. However, a good search often requires to be balanced between exploration and exploitation of the search space. In this paper, a new metaheuristic algorithm called Ringed Seal Search (RSS) is introduced. It is inspired by the natural behavior of the seal pup. This algorithm mimics the seal pup movement behavior and its ability to search and choose the best lair to escape predators. The scenario starts once the seal mother gives birth to a new pup in a birthing lair that is constructed for this purpose. The seal pup strategy consists of searching and selecting the best lair by performing a random walk to find a new lair. Affected by the sensitive nature of seals against external noise emitted by predators, the random walk of the seal pup takes two different search states, normal state and urgent state. In the normal state, the pup performs an intensive search between closely adjacent lairs; this movement is modeled via a Brownian walk. In an urgent state, the pup leaves the proximity area and performs an extensive search to find a new lair from sparse targets; this movement is modeled via a Levy walk. The switch between these two states is realized by the random noise emitted by predators. The algorithm keeps switching between normal and urgent states until the global optimum is reached. Tests and validations were performed using fifteen benchmark test functions to compare the performance of RSS with other baseline algorithms. The results show that RSS is more efficient than Genetic Algorithm, Particles Swarm Optimization and Cuckoo Search in terms of convergence rate to the global optimum. The RSS shows an improvement in terms of balance between exploration (extensive) and exploitation (intensive) of the search space. The RSS can efficiently mimic seal pups behavior to find best lair and provide a new algorithm to be used in global

  6. Ringed Seal Search for Global Optimization via a Sensitive Search Model

    PubMed Central

    Saadi, Younes; Yanto, Iwan Tri Riyadi; Herawan, Tutut; Balakrishnan, Vimala; Chiroma, Haruna; Risnumawan, Anhar

    2016-01-01

    The efficiency of a metaheuristic algorithm for global optimization is based on its ability to search and find the global optimum. However, a good search often requires to be balanced between exploration and exploitation of the search space. In this paper, a new metaheuristic algorithm called Ringed Seal Search (RSS) is introduced. It is inspired by the natural behavior of the seal pup. This algorithm mimics the seal pup movement behavior and its ability to search and choose the best lair to escape predators. The scenario starts once the seal mother gives birth to a new pup in a birthing lair that is constructed for this purpose. The seal pup strategy consists of searching and selecting the best lair by performing a random walk to find a new lair. Affected by the sensitive nature of seals against external noise emitted by predators, the random walk of the seal pup takes two different search states, normal state and urgent state. In the normal state, the pup performs an intensive search between closely adjacent lairs; this movement is modeled via a Brownian walk. In an urgent state, the pup leaves the proximity area and performs an extensive search to find a new lair from sparse targets; this movement is modeled via a Levy walk. The switch between these two states is realized by the random noise emitted by predators. The algorithm keeps switching between normal and urgent states until the global optimum is reached. Tests and validations were performed using fifteen benchmark test functions to compare the performance of RSS with other baseline algorithms. The results show that RSS is more efficient than Genetic Algorithm, Particles Swarm Optimization and Cuckoo Search in terms of convergence rate to the global optimum. The RSS shows an improvement in terms of balance between exploration (extensive) and exploitation (intensive) of the search space. The RSS can efficiently mimic seal pups behavior to find best lair and provide a new algorithm to be used in global

  7. Economic optimization of a global strategy to address the pandemic threat.

    PubMed

    Pike, Jamison; Bogich, Tiffany; Elwood, Sarah; Finnoff, David C; Daszak, Peter

    2014-12-30

    Emerging pandemics threaten global health and economies and are increasing in frequency. Globally coordinated strategies to combat pandemics, similar to current strategies that address climate change, are largely adaptive, in that they attempt to reduce the impact of a pathogen after it has emerged. However, like climate change, mitigation strategies have been developed that include programs to reduce the underlying drivers of pandemics, particularly animal-to-human disease transmission. Here, we use real options economic modeling of current globally coordinated adaptation strategies for pandemic prevention. We show that they would be optimally implemented within 27 y to reduce the annual rise of emerging infectious disease events by 50% at an estimated one-time cost of approximately $343.7 billion. We then analyze World Bank data on multilateral "One Health" pandemic mitigation programs. We find that, because most pandemics have animal origins, mitigation is a more cost-effective policy than business-as-usual adaptation programs, saving between $344.0.7 billion and $360.3 billion over the next 100 y if implemented today. We conclude that globally coordinated pandemic prevention policies need to be enacted urgently to be optimally effective and that strategies to mitigate pandemics by reducing the impact of their underlying drivers are likely to be more effective than business as usual. PMID:25512538

  8. Optimal Design of General Stiffened Composite Circular Cylinders for Global Buckling with Strength Constraints

    NASA Technical Reports Server (NTRS)

    Jaunky, N.; Ambur, D. R.; Knight, N. F., Jr.

    1998-01-01

    A design strategy for optimal design of composite grid-stiffened cylinders subjected to global and local buckling constraints and strength constraints was developed using a discrete optimizer based on a genetic algorithm. An improved smeared stiffener theory was used for the global analysis. Local buckling of skin segments were assessed using a Rayleigh-Ritz method that accounts for material anisotropy. The local buckling of stiffener segments were also assessed. Constraints on the axial membrane strain in the skin and stiffener segments were imposed to include strength criteria in the grid-stiffened cylinder design. Design variables used in this study were the axial and transverse stiffener spacings, stiffener height and thickness, skin laminate stacking sequence and stiffening configuration, where stiffening configuration is a design variable that indicates the combination of axial, transverse and diagonal stiffener in the grid-stiffened cylinder. The design optimization process was adapted to identify the best suited stiffening configurations and stiffener spacings for grid-stiffened composite cylinder with the length and radius of the cylinder, the design in-plane loads and material properties as inputs. The effect of having axial membrane strain constraints in the skin and stiffener segments in the optimization process is also studied for selected stiffening configurations.

  9. Optimal Design of General Stiffened Composite Circular Cylinders for Global Buckling with Strength Constraints

    NASA Technical Reports Server (NTRS)

    Jaunky, Navin; Knight, Norman F., Jr.; Ambur, Damodar R.

    1998-01-01

    A design strategy for optimal design of composite grid-stiffened cylinders subjected to global and local buckling constraints and, strength constraints is developed using a discrete optimizer based on a genetic algorithm. An improved smeared stiffener theory is used for the global analysis. Local buckling of skin segments are assessed using a Rayleigh-Ritz method that accounts for material anisotropy. The local buckling of stiffener segments are also assessed. Constraints on the axial membrane strain in the skin and stiffener segments are imposed to include strength criteria in the grid-stiffened cylinder design. Design variables used in this study are the axial and transverse stiffener spacings, stiffener height and thickness, skin laminate stacking sequence, and stiffening configuration, where herein stiffening configuration is a design variable that indicates the combination of axial, transverse, and diagonal stiffener in the grid-stiffened cylinder. The design optimization process is adapted to identify the best suited stiffening configurations and stiffener spacings for grid-stiffened composite cylinder with the length and radius of the cylinder, the design in-plane loads, and material properties as inputs. The effect of having axial membrane strain constraints in the skin and stiffener segments in the optimization process is also studied for selected stiffening configuration.

  10. Efficient Methods for Bayesian Uncertainty Analysis and Global Optimization of Computationally Expensive Environmental Models

    NASA Astrophysics Data System (ADS)

    Shoemaker, Christine; Espinet, Antoine; Pang, Min

    2015-04-01

    Models of complex environmental systems can be computationally expensive in order to describe the dynamic interactions of the many components over a sizeable time period. Diagnostics of these systems can include forward simulations of calibrated models under uncertainty and analysis of alternatives of systems management. This discussion will focus on applications of new surrogate optimization and uncertainty analysis methods to environmental models that can enhance our ability to extract information and understanding. For complex models, optimization and especially uncertainty analysis can require a large number of model simulations, which is not feasible for computationally expensive models. Surrogate response surfaces can be used in Global Optimization and Uncertainty methods to obtain accurate answers with far fewer model evaluations, which made the methods practical for computationally expensive models for which conventional methods are not feasible. In this paper we will discuss the application of the SOARS surrogate method for estimating Bayesian posterior density functions for model parameters for a TOUGH2 model of geologic carbon sequestration. We will also briefly discuss new parallel surrogate global optimization algorithm applied to two groundwater remediation sites that was implemented on a supercomputer with up to 64 processors. The applications will illustrate the use of these methods to predict the impact of monitoring and management on subsurface contaminants.

  11. SU-E-J-130: Automating Liver Segmentation Via Combined Global and Local Optimization

    SciTech Connect

    Li, Dengwang; Wang, Jie; Kapp, Daniel S.; Xing, Lei

    2015-06-15

    Purpose: The aim of this work is to develop a robust algorithm for accurate segmentation of liver with special attention paid to the problems with fuzzy edges and tumor. Methods: 200 CT images were collected from radiotherapy treatment planning system. 150 datasets are selected as the panel data for shape dictionary and parameters estimation. The remaining 50 datasets were used as test images. In our study liver segmentation was formulated as optimization process of implicit function. The liver region was optimized via local and global optimization during iterations. Our method consists five steps: 1)The livers from the panel data were segmented manually by physicians, and then We estimated the parameters of GMM (Gaussian mixture model) and MRF (Markov random field). Shape dictionary was built by utilizing the 3D liver shapes. 2)The outlines of chest and abdomen were located according to rib structure in the input images, and the liver region was initialized based on GMM. 3)The liver shape for each 2D slice was adjusted using MRF within the neighborhood of liver edge for local optimization. 4)The 3D liver shape was corrected by employing SSR (sparse shape representation) based on liver shape dictionary for global optimization. Furthermore, H-PSO(Hybrid Particle Swarm Optimization) was employed to solve the SSR equation. 5)The corrected 3D liver was divided into 2D slices as input data of the third step. The iteration was repeated within the local optimization and global optimization until it satisfied the suspension conditions (maximum iterations and changing rate). Results: The experiments indicated that our method performed well even for the CT images with fuzzy edge and tumors. Comparing with physician delineated results, the segmentation accuracy with the 50 test datasets (VOE, volume overlap percentage) was on average 91%–95%. Conclusion: The proposed automatic segmentation method provides a sensible technique for segmentation of CT images. This work is

  12. Optimization of murine small intestine leukocyte isolation for global immune phenotype analysis.

    PubMed

    Goodyear, Andrew W; Kumar, Ajay; Dow, Steven; Ryan, Elizabeth P

    2014-03-01

    New efforts to understand complex interactions between diet, gut microbiota, and intestinal immunity emphasize the need for a standardized murine protocol that has been optimized for the isolation of lamina propria immune cells. In this study multiple mouse strains including BALB/c, 129S6/Sv/EvTac and ICR mice were utilized to develop an optimal protocol for global analysis of lamina propria leukocytes. Incubation temperature was found to significantly improve epithelial cell removal, while changes in media formulation had minor effects. Tissue weight was an effective method for normalization of solution volumes and incubation times. Collagenase digestion in combination with thermolysin was identified as the optimal method for release of leukocytes from tissues and global immunophenotyping, based on the criteria of minimizing marker cleavage, improving cell viability, and reagent cost. The effects of collagenase in combination with dispase or thermolysin on individual cell surface markers revealed diverse marker specific effects. Aggressive formulations cleaved CD8α, CD138, and B220 from the cell surface, and resulted in relatively higher expression levels of CD3, γδ TCR, CD5, DX5, Ly6C, CD11b, CD11c, MHC-II and CD45. Improved collagenase digestion significantly improved viability and reduced debris formation, eliminating the need for density gradient purification. Finally, we demonstrate that two different digestion protocols yield significant differences in detection of CD4(+) and CD8(+) T cells, NK cells, monocytes and interdigitating DC (iDC) populations, highlighting the importance and impact of cell collection protocols on assay outputs. The optimized protocol described herein will help assure the reproducibility and robustness of global assessment of lamina propria immune responses. Moreover, this technique may be applied to isolation of leukocytes from the entire gastrointestinal tract. PMID:24508527

  13. Global-Local Analysis and Optimization of a Composite Civil Tilt-Rotor Wing

    NASA Technical Reports Server (NTRS)

    Rais-Rohani, Masound

    1999-01-01

    This report gives highlights of an investigation on the design and optimization of a thin composite wing box structure for a civil tilt-rotor aircraft. Two different concepts are considered for the cantilever wing: (a) a thin monolithic skin design, and (b) a thick sandwich skin design. Each concept is examined with three different skin ply patterns based on various combinations of 0, +/-45, and 90 degree plies. The global-local technique is used in the analysis and optimization of the six design models. The global analysis is based on a finite element model of the wing-pylon configuration while the local analysis uses a uniformly supported plate representing a wing panel. Design allowables include those on vibration frequencies, panel buckling, and material strength. The design optimization problem is formulated as one of minimizing the structural weight subject to strength, stiffness, and d,vnamic constraints. Six different loading conditions based on three different flight modes are considered in the design optimization. The results of this investigation reveal that of all the loading conditions the one corresponding to the rolling pull-out in the airplane mode is the most stringent. Also the frequency constraints are found to drive the skin thickness limits, rendering the buckling constraints inactive. The optimum skin ply pattern for the monolithic skin concept is found to be (((0/+/-45/90/(0/90)(sub 2))(sub s))(sub s), while for the sandwich skin concept the optimal ply pattern is found to be ((0/+/-45/90)(sub 2s))(sub s).

  14. Optimizing rice yields while minimizing yield-scaled global warming potential.

    PubMed

    Pittelkow, Cameron M; Adviento-Borbe, Maria A; van Kessel, Chris; Hill, James E; Linquist, Bruce A

    2014-05-01

    To meet growing global food demand with limited land and reduced environmental impact, agricultural greenhouse gas (GHG) emissions are increasingly evaluated with respect to crop productivity, i.e., on a yield-scaled as opposed to area basis. Here, we compiled available field data on CH4 and N2 O emissions from rice production systems to test the hypothesis that in response to fertilizer nitrogen (N) addition, yield-scaled global warming potential (GWP) will be minimized at N rates that maximize yields. Within each study, yield N surplus was calculated to estimate deficit or excess N application rates with respect to the optimal N rate (defined as the N rate at which maximum yield was achieved). Relationships between yield N surplus and GHG emissions were assessed using linear and nonlinear mixed-effects models. Results indicate that yields increased in response to increasing N surplus when moving from deficit to optimal N rates. At N rates contributing to a yield N surplus, N2 O and yield-scaled N2 O emissions increased exponentially. In contrast, CH4 emissions were not impacted by N inputs. Accordingly, yield-scaled CH4 emissions decreased with N addition. Overall, yield-scaled GWP was minimized at optimal N rates, decreasing by 21% compared to treatments without N addition. These results are unique compared to aerobic cropping systems in which N2 O emissions are the primary contributor to GWP, meaning yield-scaled GWP may not necessarily decrease for aerobic crops when yields are optimized by N fertilizer addition. Balancing gains in agricultural productivity with climate change concerns, this work supports the concept that high rice yields can be achieved with minimal yield-scaled GWP through optimal N application rates. Moreover, additional improvements in N use efficiency may further reduce yield-scaled GWP, thereby strengthening the economic and environmental sustainability of rice systems. PMID:24115565

  15. Global optimization approaches for finding the atomic structure of surfaces and nanowires

    NASA Astrophysics Data System (ADS)

    Ciobanu, Cristian

    2007-03-01

    In the cluster structure community, global optimization methods are common tools for seeking the structure of molecular and atomic clusters. The large number of local minima of the potential energy surface (PES) of these clusters, and the fact that these local minima proliferate exponentially with the number of atoms in the cluster simply demands the use of fast stochastic methods to find the optimum atomic configuration. Therefore, most of the development work has come from (and mostly stayed within) the cluster structure community. Partly due to wide availability and landmark successes of scanning tunneling microscopy (STM) and other high resolution microscopy techniques, finding the structure of periodically reconstructed semiconductor surfaces was not generally posed as a problem of stochastic optimization until recently [1], when we have shown that high-index semiconductor surfaces can have a rather large number of local minima with such low surface energies that the identification of the global minimum becomes problematic. We have therefore set out to develop global optimization methods for systems other than clusters, focusing on periodic systems in one- and two- dimensions as such systems currently occupy a central place in the field of nanoscience. In this talk, we review some of our recent work on global optimization methods (the parallel-tempering Monte Carlo method [1] and the genetic algorithm [2]) and show examples/results from two main problem categories: (a) the two-dimensional problem of determining the atomic configuration of clean semiconductor surfaces [1,2], and (b) finding the structure of freestanding nanowires [3]. While focused on mainly on atomic structure, our account will show examples of how these development efforts contributed to elucidating several physical problems and we will attempt to make a case for widespread use of these methods for structural problems in one and two dimenstions. [1]C.V. Ciobanu and C. Predescu, Reconstruction

  16. Research on global path planning based on ant colony optimization for AUV

    NASA Astrophysics Data System (ADS)

    Wang, Hong-Jian; Xiong, Wei

    2009-03-01

    Path planning is an important issue for autonomous underwater vehicles (AUVs) traversing an unknown environment such as a sea floor, a jungle, or the outer celestial planets. For this paper, global path planning using large-scale chart data was studied, and the principles of ant colony optimization (ACO) were applied. This paper introduced the idea of a visibility graph based on the grid workspace model. It also brought a series of pheromone updating rules for the ACO planning algorithm. The operational steps of the ACO algorithm are proposed as a model for a global path planning method for AUV. To mimic the process of smoothing a planned path, a cutting operator and an insertion-point operator were designed. Simulation results demonstrated that the ACO algorithm is suitable for global path planning. The system has many advantages, including that the operating path of the AUV can be quickly optimized, and it is shorter, safer, and smoother. The prototype system successfully demonstrated the feasibility of the concept, proving it can be applied to surveys of unstructured unmanned environments.

  17. CH4 parameter estimation in CLM4.5bgc using surrogate global optimization

    NASA Astrophysics Data System (ADS)

    Müller, J.; Paudel, R.; Shoemaker, C. A.; Woodbury, J.; Wang, Y.; Mahowald, N.

    2015-10-01

    Over the anthropocene methane has increased dramatically. Wetlands are one of the major sources of methane to the atmosphere, but the role of changes in wetland emissions is not well understood. The Community Land Model (CLM) of the Community Earth System Models contains a module to estimate methane emissions from natural wetlands and rice paddies. Our comparison of CH4 emission observations at 16 sites around the planet reveals, however, that there are large discrepancies between the CLM predictions and the observations. The goal of our study is to adjust the model parameters in order to minimize the root mean squared error (RMSE) between model predictions and observations. These parameters have been selected based on a sensitivity analysis. Because of the cost associated with running the CLM simulation (15 to 30 min on the Yellowstone Supercomputing Facility), only relatively few simulations can be allowed in order to find a near-optimal solution within an acceptable time. Our results indicate that the parameter estimation problem has multiple local minima. Hence, we use a computationally efficient global optimization algorithm that uses a radial basis function (RBF) surrogate model to approximate the objective function. We use the information from the RBF to select parameter values that are most promising with respect to improving the objective function value. We show with pseudo data that our optimization algorithm is able to make excellent progress with respect to decreasing the RMSE. Using the true CH4 emission observations for optimizing the parameters, we are able to significantly reduce the overall RMSE between observations and model predictions by about 50 %. The methane emission predictions of the CLM using the optimized parameters agree better with the observed methane emission data in northern and tropical latitudes. With the optimized parameters, the methane emission predictions are higher in northern latitudes than when the default parameters are

  18. The L_infinity constrained global optimal histogram equalization technique for real time imaging

    NASA Astrophysics Data System (ADS)

    Ren, Qiongwei; Niu, Yi; Liu, Lin; Jiao, Yang; Shi, Guangming

    2015-08-01

    Although the current imaging sensors can achieve 12 or higher precision, the current display devices and the commonly used digital image formats are still only 8 bits. This mismatch causes significant waste of the sensor precision and loss of information when storing and displaying the images. For better usage of the precision-budget, tone mapping operators have to be used to map the high-precision data into low-precision digital images adaptively. In this paper, the classic histogram equalization tone mapping operator is reexamined in the sense of optimization. We point out that the traditional histogram equalization technique and its variants are fundamentally improper by suffering from local optimum problems. To overcome this drawback, we remodel the histogram equalization tone mapping task based on graphic theory which achieves the global optimal solutions. Another advantage of the graphic-based modeling is that the tone-continuity is also modeled as a vital constraint in our approach which suppress the annoying boundary artifacts of the traditional approaches. In addition, we propose a novel dynamic programming technique to solve the histogram equalization problem in real time. Experimental results shows that the proposed tone-preserved global optimal histogram equalization technique outperforms the traditional approaches by exhibiting more subtle details in the foreground while preserving the smoothness of the background.

  19. Simulated Stochastic Approximation Annealing for Global Optimization with a Square-Root Cooling Schedule

    SciTech Connect

    Liang, Faming; Cheng, Yichen; Lin, Guang

    2014-06-13

    Simulated annealing has been widely used in the solution of optimization problems. As known by many researchers, the global optima cannot be guaranteed to be located by simulated annealing unless a logarithmic cooling schedule is used. However, the logarithmic cooling schedule is so slow that no one can afford to have such a long CPU time. This paper proposes a new stochastic optimization algorithm, the so-called simulated stochastic approximation annealing algorithm, which is a combination of simulated annealing and the stochastic approximation Monte Carlo algorithm. Under the framework of stochastic approximation Markov chain Monte Carlo, it is shown that the new algorithm can work with a cooling schedule in which the temperature can decrease much faster than in the logarithmic cooling schedule, e.g., a square-root cooling schedule, while guaranteeing the global optima to be reached when the temperature tends to zero. The new algorithm has been tested on a few benchmark optimization problems, including feed-forward neural network training and protein-folding. The numerical results indicate that the new algorithm can significantly outperform simulated annealing and other competitors.

  20. Comparison of global optimization approaches for robust calibration of hydrologic model parameters

    NASA Astrophysics Data System (ADS)

    Jung, I. W.

    2015-12-01

    Robustness of the calibrated parameters of hydrologic models is necessary to provide a reliable prediction of future performance of watershed behavior under varying climate conditions. This study investigated calibration performances according to the length of calibration period, objective functions, hydrologic model structures and optimization methods. To do this, the combination of three global optimization methods (i.e. SCE-UA, Micro-GA, and DREAM) and four hydrologic models (i.e. SAC-SMA, GR4J, HBV, and PRMS) was tested with different calibration periods and objective functions. Our results showed that three global optimization methods provided close calibration performances under different calibration periods, objective functions, and hydrologic models. However, using the agreement of index, normalized root mean square error, Nash-Sutcliffe efficiency as the objective function showed better performance than using correlation coefficient and percent bias. Calibration performances according to different calibration periods from one year to seven years were hard to generalize because four hydrologic models have different levels of complexity and different years have different information content of hydrological observation. Acknowledgements This research was supported by a grant (14AWMP-B082564-01) from Advanced Water Management Research Program funded by Ministry of Land, Infrastructure and Transport of Korean government.

  1. A Globally Optimal Particle Tracking Technique for Stereo Imaging Velocimetry Experiments

    NASA Technical Reports Server (NTRS)

    McDowell, Mark

    2008-01-01

    An important phase of any Stereo Imaging Velocimetry experiment is particle tracking. Particle tracking seeks to identify and characterize the motion of individual particles entrained in a fluid or air experiment. We analyze a cylindrical chamber filled with water and seeded with density-matched particles. In every four-frame sequence, we identify a particle track by assigning a unique track label for each camera image. The conventional approach to particle tracking is to use an exhaustive tree-search method utilizing greedy algorithms to reduce search times. However, these types of algorithms are not optimal due to a cascade effect of incorrect decisions upon adjacent tracks. We examine the use of a guided evolutionary neural net with simulated annealing to arrive at a globally optimal assignment of tracks. The net is guided both by the minimization of the search space through the use of prior limiting assumptions about valid tracks and by a strategy which seeks to avoid high-energy intermediate states which can trap the net in a local minimum. A stochastic search algorithm is used in place of back-propagation of error to further reduce the chance of being trapped in an energy well. Global optimization is achieved by minimizing an objective function, which includes both track smoothness and particle-image utilization parameters. In this paper we describe our model and present our experimental results. We compare our results with a nonoptimizing, predictive tracker and obtain an average increase in valid track yield of 27 percent

  2. Vector direction of filled function method on solving unconstrained global optimization problem

    NASA Astrophysics Data System (ADS)

    Napitupulu, Herlina; Mohd, Ismail Bin

    2016-02-01

    Filled function method is one of deterministic methods for solving global minimization problems. Filled function algorithm method generally contains of two main phases. First phase is to obtain local minimizer of objective function, second is to obtain minimizer or saddle point of filled function. In the second phase, vector direction plays an important role on finding stationary point of filled function, by assist in escaping from neighborhood of current minimizer of objective function of the first phase. In this paper, we introduce parameter free filled function and some typical vector direction to be applied in filled function algorithm. The algorithm method is implemented into some benchmark test functions. General computational and numerical results are presented to show the performance of each vector direction on filled function method for solving two dimensional unconstrained global optimization problems.

  3. Global Optimization of N-Maneuver, High-Thrust Trajectories Using Direct Multiple Shooting

    NASA Technical Reports Server (NTRS)

    Vavrina, Matthew A.; Englander, Jacob A.; Ellison, Donald H.

    2015-01-01

    The performance of impulsive, gravity-assist trajectories often improves with the inclusion of one or more maneuvers between flybys. However, grid-based scans over the entire design space can become computationally intractable for even one deep-space maneuver, and few global search routines are capable of an arbitrary number of maneuvers. To address this difficulty a trajectory transcription allow-ing for any number of maneuvers is developed within a multi-objective, global optimization framework for constrained, multiple gravity-assist trajectories. The formulation exploits a robust shooting scheme and analytic derivatives for com-putational efficiency. The approach is applied to several complex, interplanetary problems, achieving notable performance without a user-supplied initial guess.

  4. Global Optimization of N-Maneuver, High-Thrust Trajectories Using Direct Multiple Shooting

    NASA Technical Reports Server (NTRS)

    Vavrina, Matthew A.; Englander, Jacob A.; Ellison, Donald H.

    2016-01-01

    The performance of impulsive, gravity-assist trajectories often improves with the inclusion of one or more maneuvers between flybys. However, grid-based scans over the entire design space can become computationally intractable for even one deep-space maneuver, and few global search routines are capable of an arbitrary number of maneuvers. To address this difficulty a trajectory transcription allowing for any number of maneuvers is developed within a multi-objective, global optimization framework for constrained, multiple gravity-assist trajectories. The formulation exploits a robust shooting scheme and analytic derivatives for computational efficiency. The approach is applied to several complex, interplanetary problems, achieving notable performance without a user-supplied initial guess.

  5. Deterministic global optimization algorithm based on outer approximation for the parameter estimation of nonlinear dynamic biological systems

    PubMed Central

    2012-01-01

    Background The estimation of parameter values for mathematical models of biological systems is an optimization problem that is particularly challenging due to the nonlinearities involved. One major difficulty is the existence of multiple minima in which standard optimization methods may fall during the search. Deterministic global optimization methods overcome this limitation, ensuring convergence to the global optimum within a desired tolerance. Global optimization techniques are usually classified into stochastic and deterministic. The former typically lead to lower CPU times but offer no guarantee of convergence to the global minimum in a finite number of iterations. In contrast, deterministic methods provide solutions of a given quality (i.e., optimality gap), but tend to lead to large computational burdens. Results This work presents a deterministic outer approximation-based algorithm for the global optimization of dynamic problems arising in the parameter estimation of models of biological systems. Our approach, which offers a theoretical guarantee of convergence to global minimum, is based on reformulating the set of ordinary differential equations into an equivalent set of algebraic equations through the use of orthogonal collocation methods, giving rise to a nonconvex nonlinear programming (NLP) problem. This nonconvex NLP is decomposed into two hierarchical levels: a master mixed-integer linear programming problem (MILP) that provides a rigorous lower bound on the optimal solution, and a reduced-space slave NLP that yields an upper bound. The algorithm iterates between these two levels until a termination criterion is satisfied. Conclusion The capabilities of our approach were tested in two benchmark problems, in which the performance of our algorithm was compared with that of the commercial global optimization package BARON. The proposed strategy produced near optimal solutions (i.e., within a desired tolerance) in a fraction of the CPU time required by

  6. Using support vector machine and dynamic parameter encoding to enhance global optimization

    NASA Astrophysics Data System (ADS)

    Zheng, Z.; Chen, X.; Liu, C.; Huang, K.

    2016-05-01

    This study presents an approach which combines support vector machine (SVM) and dynamic parameter encoding (DPE) to enhance the run-time performance of global optimization with time-consuming fitness function evaluations. SVMs are used as surrogate models to partly substitute for fitness evaluations. To reduce the computation time and guarantee correct convergence, this work proposes a novel strategy to adaptively adjust the number of fitness evaluations needed according to the approximate error of the surrogate model. Meanwhile, DPE is employed to compress the solution space, so that it not only accelerates the convergence but also decreases the approximate error. Numerical results of optimizing a few benchmark functions and an antenna in a practical application are presented, which verify the feasibility, efficiency and robustness of the proposed approach.

  7. Global inverse optimal tracking control of underactuated omni-directional intelligent navigators (ODINs)

    NASA Astrophysics Data System (ADS)

    Do, Khac Duc

    2015-03-01

    This paper presents a design of optimal controllers with respect to a meaningful cost function to force an underactuated omni-directional intelligent navigator (ODIN) under unknown constant environmental loads to track a reference trajectory in two-dimensional space. Motivated by the vehicle's steering practice, the yaw angle regarded as a virtual control plus the surge thrust force are used to force the position of the vehicle to globally track its reference trajectory. The control design is based on several recent results developed for inverse optimal control and stability analysis of nonlinear systems, a new design of bounded disturbance observers, and backstepping and Lyapunov's direct methods. Both state- and output-feedback control designs are addressed. Simulations are included to illustrate the effectiveness of the proposed results.

  8. A Game Theoretic Optimization Method for Energy Efficient Global Connectivity in Hybrid Wireless Sensor Networks.

    PubMed

    Lee, JongHyup; Pak, Dohyun

    2016-01-01

    For practical deployment of wireless sensor networks (WSN), WSNs construct clusters, where a sensor node communicates with other nodes in its cluster, and a cluster head support connectivity between the sensor nodes and a sink node. In hybrid WSNs, cluster heads have cellular network interfaces for global connectivity. However, when WSNs are active and the load of cellular networks is high, the optimal assignment of cluster heads to base stations becomes critical. Therefore, in this paper, we propose a game theoretic model to find the optimal assignment of base stations for hybrid WSNs. Since the communication and energy cost is different according to cellular systems, we devise two game models for TDMA/FDMA and CDMA systems employing power prices to adapt to the varying efficiency of recent wireless technologies. The proposed model is defined on the assumptions of the ideal sensing field, but our evaluation shows that the proposed model is more adaptive and energy efficient than local selections. PMID:27589743

  9. A genetic algorithm for first principles global structure optimization of supported nano structures

    SciTech Connect

    Vilhelmsen, Lasse B.; Hammer, Bjørk

    2014-07-28

    We present a newly developed publicly available genetic algorithm (GA) for global structure optimisation within atomic scale modeling. The GA is focused on optimizations using first principles calculations, but it works equally well with empirical potentials. The implementation is described and benchmarked through a detailed statistical analysis employing averages across many independent runs of the GA. This analysis focuses on the practical use of GA’s with a description of optimal parameters to use. New results for the adsorption of M{sub 8} clusters (M = Ru, Rh, Pd, Ag, Pt, Au) on the stoichiometric rutile TiO{sub 2}(110) surface are presented showing the power of automated structure prediction and highlighting the diversity of metal cluster geometries at the atomic scale.

  10. Inversion of seismological data using a controlled random search global optimization technique

    NASA Astrophysics Data System (ADS)

    Shanker, K.; Mohan, C.; Khattri, K. N.

    1991-11-01

    Inversion problems in seismology deal with the estimation of the location and the time of occurrence of an earthquake from observations of the arrival time of the body waves. These problems can be regarded as non-linear optimization problems in which the objective function to be minimized is the discrepancy between the recorded arrival times and the calculated arrival times at a prescribed set of observation stations, as a function of the hypocentral parameters and the wave speed structure of the Earth. The objective of the present paper is to demonstrate the effectiveness of a controlled random search algorithm of global optimization (Shanker and Mohan, 1987; Mohan and Shanker, 1988) in solving such types of inversion problems. The performance of the algorithm has been tested on earthquake arrival time data of earthquakes recorded in the vicinity of local networks in the Garhwal Kumaon region of the Himalayas.

  11. Global geometry optimization of silicon clusters described by three empirical potentials

    NASA Astrophysics Data System (ADS)

    Yoo, S.; Zeng, X. C.

    2003-07-01

    The "basic-hopping" global optimization technique developed by Wales and Doye is employed to study the global minima of silicon clusters Sin(3⩽n⩽30) with three empirical potentials: the Stillinger-Weber (SW), the modified Stillinger-Weber (MSW), and the Gong potentials. For the small-sized SW and Gong clusters (3⩽n⩽15), it is found that the global minima obtained based on the basin-hopping method are identical to those reported by using the genetic algorithm [Iwamatsu, J. Chem. Phys. 112, 10976 (2000)], as well as with those by using molecular dynamics and the steepest-descent quench (SDQ) method [Feuston, Kalia, and Vashishta, Phys. Rev. B 37, 6297 (1988)]. However, for the mid-sized SW clusters (16⩽n⩽20), the global minima obtained differ from those based on the SDQ method, e.g., the appearance of the endohedral atom with fivefold coordination starting at n=17, as opposed to n=19. For larger SW clusters (20⩽n⩽30), it is found that the "bulklike" endohedral atom with tetrahedral coordination starts at n=20. In particular, the overall structural features of SW Si21, Si23, Si25, and Si28 are nearly identical to the MSW counterparts. With the SW Si21 as the starting structure, a geometric optimization at the B3LYP/6-31G(d) level of density-functional theory yields an isomer similar to the ground-state- isomer of Si21 reported by Pederson et al. [Phys. Rev. B 54, 2863 (1996)].

  12. Electronic neural network for solving traveling salesman and similar global optimization problems

    NASA Technical Reports Server (NTRS)

    Thakoor, Anilkumar P. (Inventor); Moopenn, Alexander W. (Inventor); Duong, Tuan A. (Inventor); Eberhardt, Silvio P. (Inventor)

    1993-01-01

    This invention is a novel high-speed neural network based processor for solving the 'traveling salesman' and other global optimization problems. It comprises a novel hybrid architecture employing a binary synaptic array whose embodiment incorporates the fixed rules of the problem, such as the number of cities to be visited. The array is prompted by analog voltages representing variables such as distances. The processor incorporates two interconnected feedback networks, each of which solves part of the problem independently and simultaneously, yet which exchange information dynamically.

  13. Implementation of a near-optimal global set point control method in a DDC controller

    SciTech Connect

    Cascia, M.A.

    2000-07-01

    A near-optimal global set point control method that can be implemented in an energy management system's (EMS) DDC controller is described in this paper. Mathematical models are presented for the power consumption of electric chillers, hot water boilers, chilled and hot water pumps, and air handler fans, which allow the calculation of near-optimal chilled water, hot water, and coil discharge air set points to minimize power consumption, based on data collected by the EMS. Also optimized are the differential and static pressure set points for the variable speed pumps and fans. A pilot test of this control methodology was implemented for a cooling plant at a pharmaceutical manufacturing facility near Dallas, Texas. Data collected at this site showed good agreement between the actual power consumed by the chillers, chilled water pumps, and air handlers and that predicted by the models. An approximate model was developed to calculate real-time power savings in the DDC controller. A third-party energy accounting program was used to track savings due to the near-optimal control, and results show a monthly KWH reduction ranging from 3% to 14%.

  14. A Global Scale 30m Water Surface Detection Optimized and Validated for Landsat 8

    NASA Astrophysics Data System (ADS)

    Pekel, J. F.; Cottam, A.; Clerici, M.; Belward, A.; Dubois, G.; Bartholome, E.; Gorelick, N.

    2014-12-01

    Life on Earth as we know it is impossible without water. Its importance to biological diversity, human well-being and the very functioning of the Earth-system cannot be overstressed, but we have remarkably little detailed knowledge concerning the spatial and temporal distribution of this vital resource. Earth observing satellites operating with high temporal revisits yet moderate spatial resolution have provided global datasets documenting spatial and temporal changes to water bodies on the Earth's surface. Landsat 8 has a data acquisition strategy such that global coverage of all land surfaces now occurs more frequently than from any preceding Landsat mission and provides 30 m resolution data. Whilst not the last word in temporal sampling this presents a basis for mapping and monitoring changes to global surface water resources at unprecedented levels of spatial detail. In this paper we provide a first 30 m resolution global synthesis of surface water occurrence, we document permanent water surfaces, seasonal water surfaces and always-dry surfaces. These products have been derived by optimizing a methodology previously developed for use with moderate resolution MODIS imagery for use with Landsat 8. The approach is based on a transformation of RGB color space into HSV combined with a sequence of cloud, topographic and temperature masks. Analysis at the global scale used the Google Earth Engine platform applied to all Landsat 8 acquisitions between June 2013 and June 2014. Systematic validation is done and demonstrated our ability to map surface water. Our method can be applied to other Landsat missions offering the potential to document changes in surface water over three decades; our study shows examples illustrating the capacity to map new water surfaces and ephemeral water surfaces in addition to the three previous classes. Thanks to an optimized data acquisition strategy, a full-free and open data policy and the processing capacity of the GEE global land

  15. Hierarchical Grid-based Multi-People Tracking-by-Detection With Global Optimization.

    PubMed

    Chen, Lili; Wang, Wei; Panin, Giorgio; Knoll, Alois

    2015-11-01

    We present a hierarchical grid-based, globally optimal tracking-by-detection approach to track an unknown number of targets in complex and dense scenarios, particularly addressing the challenges of complex interaction and mutual occlusion. Frame-by-frame detection is performed by hierarchical likelihood grids, matching shape templates through a fast oriented distance transform. To allow recovery from misdetections, common heuristics such as nonmaxima suppression within observations is eschewed. Within a discretized state-space, the data association problem is formulated as a grid-based network flow model, resulting in a convex problem casted into an integer linear programming form, giving a global optimal solution. In addition, we show how a behavior cue (body orientation) can be integrated into our association affinity model, providing valuable hints for resolving ambiguities between crossing trajectories. Unlike traditional motion-based approaches, we estimate body orientation by a hybrid methodology, which combines the merits of motion-based and 3D appearance-based orientation estimation, thus being capable of dealing also with still-standing or slowly moving targets. The performance of our method is demonstrated through experiments on a large variety of benchmark video sequences, including both indoor and outdoor scenarios. PMID:26151936

  16. Global design optimization for an axial-flow tandem pump based on surrogate method

    NASA Astrophysics Data System (ADS)

    Li, D. H.; Zhao, Y.; Y Wang, G.

    2013-12-01

    Tandem pump, compared with multistage pump, goes without guide vanes between impellers. Better cavitation performance and significant reduction of the axial geometry scale is important for high-speed propulsion. This study presents a global design optimization method based on surrogated method for an axial-flow tandem pump to enhance trade-off performances: energy and cavitation performances. At the same time, interactions between impellers and impacts on the performances are analyzed. Fixed angle of blades in impellers and phase angle are performed as design variables. Efficiency and minimum average pressure coefficient (MAPC) on axial sectional surface in front impeller are the objective function, which can represent energy and cavitation performances well. Different surrogate models are constructed, and Global Sensitivity Analysis and Pareto Front method are used. The results show that, 1) Influence from phase angle on performances can be neglected compared with other two design variables, 2) Impact ratio of fixed angle of blades in two impellers on efficiency are the same as their designed loading distributions, which is 4:6, 3) The optimization results can enhance the trade-off performances well: efficiency is improved by 0.6%, and the MAPC is improved by 4.5%.

  17. CH4 parameter estimation in CLM4.5bgc using surrogate global optimization

    NASA Astrophysics Data System (ADS)

    Müller, J.; Paudel, R.; Shoemaker, C. A.; Woodbury, J.; Wang, Y.; Mahowald, N.

    2015-01-01

    Over the anthropocene methane has increased dramatically. Wetlands are one of the major sources of methane to the atmosphere, but the role of changes in wetland emissions is not well understood. The Community Land Model (CLM) of the Community Earth System Models contains a module to estimate methane emissions from natural wetlands and rice paddies. Our comparison of CH4 emission observations at 16 sites around the planet reveals, however, that there are large discrepancies between the CLM predictions and the observations. The goal of our study is to adjust the model parameters in order to minimize the root mean squared error (RMSE) between model predictions and observations. These parameters have been selected based on a sensitivity analysis. Because of the cost associated with running the CLM simulation (15 to 30 min on the Yellowstone Supercomputing Facility), only relatively few simulations can be allowed in order to find a near optimal solution within an acceptable time. Our results indicate that the parameter estimation problem has multiple local minima. Hence, we use a computationally efficient global optimization algorithm that uses a radial basis function (RBF) surrogate model to approximate the objective function. We use the information from the RBF to select parameter values that are most promising with respect to improving the objective function value. We show with pseudo data that our optimization algorithm is able to make excellent progress with respect to decreasing the RMSE. Using the true CH4 emission observations for optimizing the parameters, we are able to significantly reduce the overall RMSE between observations and model predictions by about 50%. The CLM predictions with the optimized parameters agree for northern and tropical latitudes more with the observed data than when using the default parameters and the emission predictions are higher than with default settings in northern latitudes and lower than default settings in the tropics.

  18. Export dynamics as an optimal growth problem in the network of global economy.

    PubMed

    Caraglio, Michele; Baldovin, Fulvio; Stella, Attilio L

    2016-01-01

    We analyze export data aggregated at world global level of 219 classes of products over a period of 39 years. Our main goal is to set up a dynamical model to identify and quantify plausible mechanisms by which the evolutions of the various exports affect each other. This is pursued through a stochastic differential description, partly inspired by approaches used in population dynamics or directed polymers in random media. We outline a complex network of transfer rates which describes how resources are shifted between different product classes, and determines how casual favorable conditions for one export can spread to the other ones. A calibration procedure allows to fit four free model-parameters such that the dynamical evolution becomes consistent with the average growth, the fluctuations, and the ranking of the export values observed in real data. Growth crucially depends on the balance between maintaining and shifting resources to different exports, like in an explore-exploit problem. Remarkably, the calibrated parameters warrant a close-to-maximum growth rate under the transient conditions realized in the period covered by data, implying an optimal self organization of the global export. According to the model, major structural changes in the global economy take tens of years. PMID:27530505

  19. Global optimization on set of mixed variables: continuous and discrete with unordered possible values

    NASA Astrophysics Data System (ADS)

    Mikhalev, A. S.; Rouban, A. I.

    2016-04-01

    The algorithms of global non-differentiable minimization of functions on set of the mixed variables: continuous and discrete with unordered specific possible values are constructed. The method of optimization is based on selective averaging of required variables, on adaptive reorganization of the sizes of admissible domain of trial movements and on use of relative values for minimised functions. Existence of discrete variables leads to solution of a sequence of global minimization problems of the functions in space of only continuous variables at the presence: 1) of their inequality restrictions for each problem; 2) of the general inequality restrictions for all problems (i.e. at the absence of dependence of functions fore inequality restrictions from discrete variables). In the first case, presence of discrete variables with unordered non-numeric possible values leads to solution of sequence of problems of global minimization of multiextreme functions on set only of continuous variables at the presence of their inequality restrictions. As a result, among the received optimum solutions the best is selected. In the second variant all minimized functions is convoluted in each sampling point in one multiextreme function and this function is minimised on continuous variables.

  20. Potential of Global Cropland Phytolith Carbon Sink from Optimization of Cropping System and Fertilization

    PubMed Central

    Song, Zhaoliang; Parr, Jeffrey F.; Guo, Fengshan

    2013-01-01

    The occlusion of carbon (C) by phytoliths, the recalcitrant silicified structures deposited within plant tissues, is an important persistent C sink mechanism for croplands and other grass-dominated ecosystems. By constructing a silica content-phytolith content transfer function and calculating the magnitude of phytolith C sink in global croplands with relevant crop production data, this study investigated the present and potential of phytolith C sinks in global croplands and its contribution to the cropland C balance to understand the cropland C cycle and enhance long-term C sequestration in croplands. Our results indicate that the phytolith sink annually sequesters 26.35±10.22 Tg of carbon dioxide (CO2) and may contribute 40±18% of the global net cropland soil C sink for 1961–2100. Rice (25%), wheat (19%) and maize (23%) are the dominant contributing crop species to this phytolith C sink. Continentally, the main contributors are Asia (49%), North America (17%) and Europe (16%). The sink has tripled since 1961, mainly due to fertilizer application and irrigation. Cropland phytolith C sinks may be further enhanced by adopting cropland management practices such as optimization of cropping system and fertilization. PMID:24066067

  1. Export dynamics as an optimal growth problem in the network of global economy

    PubMed Central

    Caraglio, Michele; Baldovin, Fulvio; Stella, Attilio L.

    2016-01-01

    We analyze export data aggregated at world global level of 219 classes of products over a period of 39 years. Our main goal is to set up a dynamical model to identify and quantify plausible mechanisms by which the evolutions of the various exports affect each other. This is pursued through a stochastic differential description, partly inspired by approaches used in population dynamics or directed polymers in random media. We outline a complex network of transfer rates which describes how resources are shifted between different product classes, and determines how casual favorable conditions for one export can spread to the other ones. A calibration procedure allows to fit four free model-parameters such that the dynamical evolution becomes consistent with the average growth, the fluctuations, and the ranking of the export values observed in real data. Growth crucially depends on the balance between maintaining and shifting resources to different exports, like in an explore-exploit problem. Remarkably, the calibrated parameters warrant a close-to-maximum growth rate under the transient conditions realized in the period covered by data, implying an optimal self organization of the global export. According to the model, major structural changes in the global economy take tens of years. PMID:27530505

  2. Time Resolved Temperature Measurement of Hypervelocity Impact Generated Plasma Using a Global Optimization Method

    NASA Astrophysics Data System (ADS)

    Hew, Y. M.; Linscott, I.; Close, S.

    2015-12-01

    Meteoroids and orbital debris, collectively referred to as hypervelocity impactors, travel between 7 and 72 km/s in free space. Upon their impact onto the spacecraft, the energy conversion from kinetic to ionization/vaporization occurs within a very brief timescale and results in a small and dense expanding plasma with a very strong optical flash. The radio frequency (RF) emission produced by this plasma can potentially lead to electrical anomalies within the spacecraft. In addition, space weather, such as solar activity and background plasma, can establish spacecraft conditions which can exaggerate the damages done by these impacts. During the impact, a very strong impact flash will be generated. Through the studying of this emission spectrum of the impact, we hope to study the impact generated gas cloud/plasma properties. The impact flash emitted from a ground-based hypervelocity impact test is long expected by many scientists to contain the characteristics of the impact generated plasma, such as plasma temperature and density. This paper presents a method for the time-resolved plasma temperature estimation using three-color visible band photometry data with a global pattern search optimization method. The equilibrium temperature of the plasma can be estimated using an optical model which accounts for both the line emission and continuum emission from the plasma. Using a global pattern search based optimizer, the model can isolate the contribution of the continuum emission versus the line emission from the plasma. The plasma temperature can thus be estimated. Prior to the optimization step, a Gaussian process is also applied to extract the optical emission signal out of the noisy background. The resultant temperature and line-to-continuum emission weighting factor are consistent with the spectrum of the impactor material and current literature.

  3. Region detection by minimizing intraclass variance with geometric constraints, global optimality, and efficient approximation.

    PubMed

    Wu, Xiaodong; Dou, Xin; Wahle, Andreas; Sonka, Milan

    2011-03-01

    Efficient segmentation of globally optimal surfaces in volumetric images is a central problem in many medical image analysis applications. Intraclass variance has been successfully utilized for object segmentation, for instance, in the Chan-Vese model, especially for images without prominent edges. In this paper, we study the optimization problem of detecting a region (volume) between two coupled smooth surfaces by minimizing the intraclass variance using an efficient polynomial-time algorithm. Our algorithm is based on the shape probing technique in computational geometry and computes a sequence of minimum-cost closed sets in a derived parametric graph. The method has been validated on computer-synthetic volumetric images and in X-ray CT-scanned datasets of plexiglas tubes of known sizes. Its applicability to clinical data sets was also demonstrated. In all cases, the approach yielded highly accurate results. We believe that the developed technique is of interest on its own. We expect that it can shed some light on solving other important optimization problems arising in medical imaging. Furthermore, we report an approximation algorithm which runs much faster than the exact algorithm while yielding highly comparable segmentation accuracy. PMID:21118766

  4. Determination of the Johnson-Cook Constitutive Model Parameters of Materials by Cluster Global Optimization Algorithm

    NASA Astrophysics Data System (ADS)

    Huang, Zhipeng; Gao, Lihong; Wang, Yangwei; Wang, Fuchi

    2016-06-01

    The Johnson-Cook (J-C) constitutive model is widely used in the finite element simulation, as this model shows the relationship between stress and strain in a simple way. In this paper, a cluster global optimization algorithm is proposed to determine the J-C constitutive model parameters of materials. A set of assumed parameters is used for the accuracy verification of the procedure. The parameters of two materials (401 steel and 823 steel) are determined. Results show that the procedure is reliable and effective. The relative error between the optimized and assumed parameters is no more than 4.02%, and the relative error between the optimized and assumed stress is 0.2% × 10-5. The J-C constitutive parameters can be determined more precisely and quickly than the traditional manual procedure. Furthermore, all the parameters can be simultaneously determined using several curves under different experimental conditions. A strategy is also proposed to accurately determine the constitutive parameters.

  5. Globally Optimal Base Station Clustering in Interference Alignment-Based Multicell Networks

    NASA Astrophysics Data System (ADS)

    Brandt, Rasmus; Mochaourab, Rami; Bengtsson, Mats

    2016-04-01

    Coordinated precoding based on interference alignment is a promising technique for improving the throughputs in future wireless multicell networks. In small networks, all base stations can typically jointly coordinate their precoding. In large networks however, base station clustering is necessary due to the otherwise overwhelmingly high channel state information (CSI) acquisition overhead. In this work, we provide a branch and bound algorithm for finding the globally optimal base station clustering. The algorithm is mainly intended for benchmarking existing suboptimal clustering schemes. We propose a general model for the user throughputs, which only depends on the long-term CSI statistics. The model assumes intracluster interference alignment and is able to account for the CSI acquisition overhead. By enumerating a search tree using a best-first search and pruning sub-trees in which the optimal solution provably cannot be, the proposed method converges to the optimal solution. The pruning is done using specifically derived bounds, which exploit some assumed structure in the throughput model. It is empirically shown that the proposed method has an average complexity which is orders of magnitude lower than that of exhaustive search.

  6. Searchlight Correlation Detectors: Optimal Seismic Monitoring Using Regional and Global Networks

    NASA Astrophysics Data System (ADS)

    Gibbons, Steven J.; Kværna, Tormod; Näsholm, Sven Peter

    2015-04-01

    The sensitivity of correlation detectors increases greatly when the outputs from multiple seismic traces are considered. For single-array monitoring, a zero-offset stack of individual correlation traces will provide significant noise suppression and enhanced sensitivity for a source region surrounding the hypocenter of the master event. The extent of this region is limited only by the decrease in waveform similarity with increasing hypocenter separation. When a regional or global network of arrays and/or 3-component stations is employed, the zero-offset approach is only optimal when the master and detected events are co-located exactly. In many monitoring situations, including nuclear test sites and geothermal fields, events may be separated by up to many hundreds of meters while still retaining sufficient waveform similarity for correlation detection on single channels. However, the traveltime differences resulting from the hypocenter separation may result in significant beam loss on the zero-offset stack and a deployment of many beams for different hypothetical source locations in geographical space is required. The beam deployment necessary for optimal performance of the correlation detectors is determined by an empirical network response function which is most easily evaluated using the auto-correlation functions of the waveform templates from the master event. The correlation detector beam deployments for providing optimal network sensitivity for the North Korea nuclear test site are demonstrated for both regional and teleseismic monitoring configurations.

  7. Selection of Thermal Worst-Case Orbits via Modified Efficient Global Optimization

    NASA Technical Reports Server (NTRS)

    Moeller, Timothy M.; Wilhite, Alan W.; Liles, Kaitlin A.

    2014-01-01

    Efficient Global Optimization (EGO) was used to select orbits with worst-case hot and cold thermal environments for the Stratospheric Aerosol and Gas Experiment (SAGE) III. The SAGE III system thermal model changed substantially since the previous selection of worst-case orbits (which did not use the EGO method), so the selections were revised to ensure the worst cases are being captured. The EGO method consists of first conducting an initial set of parametric runs, generated with a space-filling Design of Experiments (DoE) method, then fitting a surrogate model to the data and searching for points of maximum Expected Improvement (EI) to conduct additional runs. The general EGO method was modified by using a multi-start optimizer to identify multiple new test points at each iteration. This modification facilitates parallel computing and decreases the burden of user interaction when the optimizer code is not integrated with the model. Thermal worst-case orbits for SAGE III were successfully identified and shown by direct comparison to be more severe than those identified in the previous selection. The EGO method is a useful tool for this application and can result in computational savings if the initial Design of Experiments (DoE) is selected appropriately.

  8. Selection of optimal oligonucleotide probes for microarrays using multiple criteria, global alignment and parameter estimation

    PubMed Central

    Li, Xingyuan; He, Zhili; Zhou, Jizhong

    2005-01-01

    The oligonucleotide specificity for microarray hybridization can be predicted by its sequence identity to non-targets, continuous stretch to non-targets, and/or binding free energy to non-targets. Most currently available programs only use one or two of these criteria, which may choose ‘false’ specific oligonucleotides or miss ‘true’ optimal probes in a considerable proportion. We have developed a software tool, called CommOligo using new algorithms and all three criteria for selection of optimal oligonucleotide probes. A series of filters, including sequence identity, free energy, continuous stretch, GC content, self-annealing, distance to the 3′-untranslated region (3′-UTR) and melting temperature (Tm), are used to check each possible oligonucleotide. A sequence identity is calculated based on gapped global alignments. A traversal algorithm is used to generate alignments for free energy calculation. The optimal Tm interval is determined based on probe candidates that have passed all other filters. Final probes are picked using a combination of user-configurable piece-wise linear functions and an iterative process. The thresholds for identity, stretch and free energy filters are automatically determined from experimental data by an accessory software tool, CommOligo_PE (CommOligo Parameter Estimator). The program was used to design probes for both whole-genome and highly homologous sequence data. CommOligo and CommOligo_PE are freely available to academic users upon request. PMID:16246912

  9. GalaxyDock2: protein-ligand docking using beta-complex and global optimization.

    PubMed

    Shin, Woong-Hee; Kim, Jae-Kwan; Kim, Deok-Soo; Seok, Chaok

    2013-11-15

    In this article, an enhanced version of GalaxyDock protein-ligand docking program is introduced. GalaxyDock performs conformational space annealing (CSA) global optimization to find the optimal binding pose of a ligand both in the rigid-receptor mode and the flexible-receptor mode. Binding pose prediction has been improved compared to the earlier version by the efficient generation of high-quality initial conformations for CSA using a predocking method based on a beta-complex derived from the Voronoi diagram of receptor atoms. Binding affinity prediction has also been enhanced by using the optimal combination of energy components, while taking into consideration the energy of the unbound ligand state. The new version has been tested in terms of binding mode prediction, binding affinity prediction, and virtual screening on several benchmark sets, showing improved performance over the previous version and AutoDock, on which the GalaxyDock energy function is based. GalaxyDock2 also performs better than or comparable to other state-of-the-art docking programs. GalaxyDock2 is freely available at http://galaxy.seoklab.org/softwares/galaxydock.html. PMID:24108416

  10. Efficient Parallel Global Optimization for High Resolution Hydrologic and Climate Impact Models

    NASA Astrophysics Data System (ADS)

    Shoemaker, C. A.; Mueller, J.; Pang, M.

    2013-12-01

    High Resolution hydrologic models are typically computationally expensive, requiring many minutes or perhaps hours for one simulation. Optimization can be used with these models for parameter estimation or for analyzing management alternatives. However Optimization of these computationally expensive simulations requires algorithms that can obtain accurate answers with relatively few simulations to avoid infeasibly long computation times. We have developed a number of efficient parallel algorithms and software codes for optimization of expensive problems with multiple local minimum. This is open source software we are distributing. It runs in Matlab and Python, and has been run on Yellowstone supercomputer. The talk will quickly discuss the characteristics of the problem (e.g. the presence of integer as well as continuous variables, the number of dimensions, the availability of parallel/grid computing, the number of simulations that can be allowed to find a solution, etc. ) that determine which algorithms are most appropriate for each type of problem. A major application of this optimization software is for parameter estimation for nonlinear hydrologic models, including contaminant transport in subsurface (e.g. for groundwater remediation or multi-phase flow for carbon sequestration), nutrient transport in watersheds, and climate models. We will present results for carbon sequestration plume monitoring (multi-phase, multi-constiuent), for groundwater remediation, and for the CLM climate model. The carbon sequestration example is based on the Frio CO2 field site and the groundwater example is for a 50,000 acre remediation site (with model requiring about 1 hour per simulation). Parallel speed-ups are excellent in most cases, and our serial and parallel algorithms tend to outperform alternative methods on complex computationally expensive simulations that have multiple global minima.

  11. Genetically controlled random search: a global optimization method for continuous multidimensional functions

    NASA Astrophysics Data System (ADS)

    Tsoulos, Ioannis G.; Lagaris, Isaac E.

    2006-01-01

    A new stochastic method for locating the global minimum of a multidimensional function inside a rectangular hyperbox is presented. A sampling technique is employed that makes use of the procedure known as grammatical evolution. The method can be considered as a "genetic" modification of the Controlled Random Search procedure due to Price. The user may code the objective function either in C++ or in Fortran 77. We offer a comparison of the new method with others of similar structure, by presenting results of computational experiments on a set of test functions. Program summaryTitle of program: GenPrice Catalogue identifier:ADWP Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWP Program available from: CPC Program Library, Queen's University of Belfast, N. Ireland Computer for which the program is designed and others on which it has been tested: the tool is designed to be portable in all systems running the GNU C++ compiler Installation: University of Ioannina, Greece Programming language used: GNU-C++, GNU-C, GNU Fortran-77 Memory required to execute with typical data: 200 KB No. of bits in a word: 32 No. of processors used: 1 Has the code been vectorized or parallelized?: no No. of lines in distributed program, including test data, etc.:13 135 No. of bytes in distributed program, including test data, etc.: 78 512 Distribution format: tar. gz Nature of physical problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques are frequently trapped in local minima. Global optimization is hence the appropriate tool. For example, solving a nonlinear system of equations via optimization, employing a "least squares" type of objective, one may encounter many local minima that do not correspond to solutions, i.e. minima with values

  12. Optimizing Orbit-Instrument Configuration for Global Precipitation Mission (GPM) Satellite Fleet

    NASA Technical Reports Server (NTRS)

    Smith, Eric A.; Adams, James; Baptista, Pedro; Haddad, Ziad; Iguchi, Toshio; Im, Eastwood; Kummerow, Christian; Einaudi, Franco (Technical Monitor)

    2001-01-01

    Following the scientific success of the Tropical Rainfall Measuring Mission (TRMM) spearheaded by a group of NASA and NASDA scientists, their external scientific collaborators, and additional investigators within the European Union's TRMM Research Program (EUROTRMM), there has been substantial progress towards the development of a new internationally organized, global scale, and satellite-based precipitation measuring mission. The highlights of this newly developing mission are a greatly expanded scope of measuring capability and a more diversified set of science objectives. The mission is called the Global Precipitation Mission (GPM). Notionally, GPM will be a constellation-type mission involving a fleet of nine satellites. In this fleet, one member is referred to as the "core" spacecraft flown in an approximately 70 degree inclined non-sun-synchronous orbit, somewhat similar to TRMM in that it carries both a multi-channel polarized passive microwave radiometer (PMW) and a radar system, but in this case it will be a dual frequency Ku-Ka band radar system enabling explicit measurements of microphysical DSD properties. The remainder of fleet members are eight orbit-synchronized, sun-synchronous "constellation" spacecraft each carrying some type of multi-channel PMW radiometer, enabling no worse than 3-hour diurnal sampling over the entire globe. In this configuration the "core" spacecraft serves as a high quality reference platform for training and calibrating the PMW rain retrieval algorithms used with the "constellation" radiometers. Within NASA, GPM has advanced to the pre-formulation phase which has enabled the initiation of a set of science and technology studies which will help lead to the final mission design some time in the 2003 period. This presentation first provides an overview of the notional GPM program and mission design, including its organizational and programmatic concepts, scientific agenda, expected instrument package, and basic flight

  13. Automated reconstruction of dendritic and axonal trees by global optimization with geometric priors.

    PubMed

    Türetken, Engin; González, Germán; Blum, Christian; Fua, Pascal

    2011-09-01

    We present a novel probabilistic approach to fully automated delineation of tree structures in noisy 2D images and 3D image stacks. Unlike earlier methods that rely mostly on local evidence, ours builds a set of candidate trees over many different subsets of points likely to belong to the optimal tree and then chooses the best one according to a global objective function that combines image evidence with geometric priors. Since the best tree does not necessarily span all the points, the algorithm is able to eliminate false detections while retaining the correct tree topology. Manually annotated brightfield micrographs, retinal scans and the DIADEM challenge datasets are used to evaluate the performance of our method. We used the DIADEM metric to quantitatively evaluate the topological accuracy of the reconstructions and showed that the use of the geometric regularization yields a substantial improvement. PMID:21573886

  14. Multi-view stereo image synthesis using binocular symmetry-based global optimization

    NASA Astrophysics Data System (ADS)

    Kim, Hak Gu; Jung, Yong Ju; Yoon, Soo Sung; Ro, Yong Man

    2015-03-01

    This paper presents a new multi-view stereo image synthesis using binocular symmetric hole filling. In autostereoscopic displays, multi-view synthesis is needed to provide multiple perspectives of the same scene, as viewed from multiple viewing positions. In the warped image at a distant virtual viewpoint, it is difficult to generate visually plausible multi-view stereo images in multi-view synthesis since very large hole regions (i.e., disoccluded regions) could be induced. Also, binocular asymmetry between the synthesized left-eye and right-eye images is one of the critical factors, which leads to a visual discomfort in stereoscopic viewing. In this paper, we maintain the binocular symmetry using the already filled regions in an adjacent view. The proposed method introduces a binocular symmetric hole filling based on the global optimization for binocular symmetry in the synthesized multi-view stereo images. The experimental results showed that the proposed method outperformed those of the existing methods.

  15. Efficient and Optimal Attitude Determination Using Recursive Global Positioning System Signal Operations

    NASA Technical Reports Server (NTRS)

    Crassidis, John L.; Lightsey, E. Glenn; Markley, F. Landis

    1998-01-01

    In this paper, a new and efficient algorithm is developed for attitude determination from Global Positioning System signals. The new algorithm is derived from a generalized nonlinear predictive filter for nonlinear systems. This uses a one time-step ahead approach to propagate a simple kinematics model for attitude determination. The advantages of the new algorithm over previously developed methods include: it provides optimal attitudes even for coplanar baseline configurations; it guarantees convergence even for poor initial conditions; it is a non-iterative algorithm; and it is computationally efficient. These advantages clearly make the new algorithm well suited to on-board applications. The performance of the new algorithm is tested on a dynamic hardware simulator. Results indicate that the new algorithm accurately estimates the attitude of a moving vehicle, and provides robust attitude estimates even when other methods, such as a linearized least-squares approach, fail due to poor initial starting conditions.

  16. Globally optimal rotation alignment of spherical surfaces with associated scalar values

    NASA Astrophysics Data System (ADS)

    Pan, Rongjiang; Skala, Vaclav; Müller, Rolf

    2013-09-01

    We propose a new approach to global optimization algorithm based on controlled random search techniques for rotational alignment of spherical surfaces with associated scalar values. To reduce the distortion in correspondence and increase efficiency, the spherical surface is first re-sampled using a geodesic sphere. The rotation in space is represented using the modified Rodrigues parameters. Correspondence between two spherical surfaces is implemented in the parametric domain. We applied the methods to the alignment of beam patterns computed from the outer ear shapes of bats. The proposed method is compared with other approaches such as principal component analysis (PCA), exhaustive search in the discrete space of rotations defined by Euler angles and direct search using uniform samples over the special orthogonal group of rotations in 3D space. Experimental results demonstrate that the rotation alignment obtained using the proposed algorithm has a high degree of precision and gives the best results among the four approaches. [Figure not available: see fulltext.

  17. A Neurodynamic Optimization Method for Recovery of Compressive Sensed Signals With Globally Converged Solution Approximating to l0 Minimization.

    PubMed

    Guo, Chengan; Yang, Qingshan

    2015-07-01

    Finding the optimal solution to the constrained l0 -norm minimization problems in the recovery of compressive sensed signals is an NP-hard problem and it usually requires intractable combinatorial searching operations for getting the global optimal solution, unless using other objective functions (e.g., the l1 norm or lp norm) for approximate solutions or using greedy search methods for locally optimal solutions (e.g., the orthogonal matching pursuit type algorithms). In this paper, a neurodynamic optimization method is proposed to solve the l0 -norm minimization problems for obtaining the global optimum using a recurrent neural network (RNN) model. For the RNN model, a group of modified Gaussian functions are constructed and their sum is taken as the objective function for approximating the l0 norm and for optimization. The constructed objective function sets up a convexity condition under which the neurodynamic system is guaranteed to obtain the globally convergent optimal solution. An adaptive adjustment scheme is developed for improving the performance of the optimization algorithm further. Extensive experiments are conducted to test the proposed approach in this paper and the output results validate the effectiveness of the new method. PMID:25122603

  18. Local search for optimal global map generation using mid-decadal landsat images

    USGS Publications Warehouse

    Khatib, L.; Gasch, J.; Morris, R.; Covington, S.

    2007-01-01

    NASA and the US Geological Survey (USGS) are seeking to generate a map of the entire globe using Landsat 5 Thematic Mapper (TM) and Landsat 7 Enhanced Thematic Mapper Plus (ETM+) sensor data from the "mid-decadal" period of 2004 through 2006. The global map is comprised of thousands of scene locations and, for each location, tens of different images of varying quality to chose from. Furthermore, it is desirable for images of adjacent scenes be close together in time of acquisition, to avoid obvious discontinuities due to seasonal changes. These characteristics make it desirable to formulate an automated solution to the problem of generating the complete map. This paper formulates a Global Map Generator problem as a Constraint Optimization Problem (GMG-COP) and describes an approach to solving it using local search. Preliminary results of running the algorithm on image data sets are summarized. The results suggest a significant improvement in map quality using constraint-based solutions. Copyright ?? 2007, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

  19. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

    PubMed

    Sartelli, Massimo; Weber, Dieter G; Ruppé, Etienne; Bassetti, Matteo; Wright, Brian J; Ansaloni, Luca; Catena, Fausto; Coccolini, Federico; Abu-Zidan, Fikri M; Coimbra, Raul; Moore, Ernest E; Moore, Frederick A; Maier, Ronald V; De Waele, Jan J; Kirkpatrick, Andrew W; Griffiths, Ewen A; Eckmann, Christian; Brink, Adrian J; Mazuski, John E; May, Addison K; Sawyer, Rob G; Mertz, Dominik; Montravers, Philippe; Kumar, Anand; Roberts, Jason A; Vincent, Jean-Louis; Watkins, Richard R; Lowman, Warren; Spellberg, Brad; Abbott, Iain J; Adesunkanmi, Abdulrashid Kayode; Al-Dahir, Sara; Al-Hasan, Majdi N; Agresta, Ferdinando; Althani, Asma A; Ansari, Shamshul; Ansumana, Rashid; Augustin, Goran; Bala, Miklosh; Balogh, Zsolt J; Baraket, Oussama; Bhangu, Aneel; Beltrán, Marcelo A; Bernhard, Michael; Biffl, Walter L; Boermeester, Marja A; Brecher, Stephen M; Cherry-Bukowiec, Jill R; Buyne, Otmar R; Cainzos, Miguel A; Cairns, Kelly A; Camacho-Ortiz, Adrian; Chandy, Sujith J; Che Jusoh, Asri; Chichom-Mefire, Alain; Colijn, Caroline; Corcione, Francesco; Cui, Yunfeng; Curcio, Daniel; Delibegovic, Samir; Demetrashvili, Zaza; De Simone, Belinda; Dhingra, Sameer; Diaz, José J; Di Carlo, Isidoro; Dillip, Angel; Di Saverio, Salomone; Doyle, Michael P; Dorj, Gereltuya; Dogjani, Agron; Dupont, Hervé; Eachempati, Soumitra R; Enani, Mushira Abdulaziz; Egiev, Valery N; Elmangory, Mutasim M; Ferrada, Paula; Fitchett, Joseph R; Fraga, Gustavo P; Guessennd, Nathalie; Giamarellou, Helen; Ghnnam, Wagih; Gkiokas, George; Goldberg, Staphanie R; Gomes, Carlos Augusto; Gomi, Harumi; Guzmán-Blanco, Manuel; Haque, Mainul; Hansen, Sonja; Hecker, Andreas; Heizmann, Wolfgang R; Herzog, Torsten; Hodonou, Adrien Montcho; Hong, Suk-Kyung; Kafka-Ritsch, Reinhold; Kaplan, Lewis J; Kapoor, Garima; Karamarkovic, Aleksandar; Kees, Martin G; Kenig, Jakub; Kiguba, Ronald; Kim, Peter K; Kluger, Yoram; Khokha, Vladimir; Koike, Kaoru; Kok, Kenneth Y Y; Kong, Victory; Knox, Matthew C; Inaba, Kenji; Isik, Arda; Iskandar, Katia; Ivatury, Rao R; Labbate, Maurizio; Labricciosa, Francesco M; Laterre, Pierre-François; Latifi, Rifat; Lee, Jae Gil; Lee, Young Ran; Leone, Marc; Leppaniemi, Ari; Li, Yousheng; Liang, Stephen Y; Loho, Tonny; Maegele, Marc; Malama, Sydney; Marei, Hany E; Martin-Loeches, Ignacio; Marwah, Sanjay; Massele, Amos; McFarlane, Michael; Melo, Renato Bessa; Negoi, Ionut; Nicolau, David P; Nord, Carl Erik; Ofori-Asenso, Richard; Omari, AbdelKarim H; Ordonez, Carlos A; Ouadii, Mouaqit; Pereira Júnior, Gerson Alves; Piazza, Diego; Pupelis, Guntars; Rawson, Timothy Miles; Rems, Miran; Rizoli, Sandro; Rocha, Claudio; Sakakhushev, Boris; Sanchez-Garcia, Miguel; Sato, Norio; Segovia Lohse, Helmut A; Sganga, Gabriele; Siribumrungwong, Boonying; Shelat, Vishal G; Soreide, Kjetil; Soto, Rodolfo; Talving, Peep; Tilsed, Jonathan V; Timsit, Jean-Francois; Trueba, Gabriel; Trung, Ngo Tat; Ulrych, Jan; van Goor, Harry; Vereczkei, Andras; Vohra, Ravinder S; Wani, Imtiaz; Uhl, Waldemar; Xiao, Yonghong; Yuan, Kuo-Ching; Zachariah, Sanoop K; Zahar, Jean-Ralph; Zakrison, Tanya L; Corcione, Antonio; Melotti, Rita M; Viscoli, Claudio; Viale, Perluigi

    2016-01-01

    Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs. PMID:27429642

  20. Optimizing global CO concentrations and emissions based on DART/CAM-CHEM

    NASA Astrophysics Data System (ADS)

    Gaubert, B.; Arellano, A. F.; Barre, J.; Worden, H. M.; Emmons, L. K.; Wiedinmyer, C.; Anderson, J. L.; Deeter, M. N.; Mizzi, A. P.; Edwards, D. P.

    2014-12-01

    Atmospheric Carbon Monoxide (CO) is an important trace gas in tropospheric chemistry through its impact on the oxidizing capacity of the troposphere, as precursor of ozone, and as a good tracer of combustion from both anthropogenic sources and wildfires. We will investigate the potential of the assimilation of TERRA/MOPITT observations to constrain the regional to global CO budget using DART (Data assimilation Research Testbed) together with the global Community Atmospheric Model (CAM-Chem). DART/CAM-Chem is based on an ensemble adjustment Kalman filter (EAKF) framework which facilitates statistical estimation of error correlations between chemical states (CO and related species) and parameters (including sources) in the model using the ensemble statistics derived from dynamical and chemical perturbations in the model. Here, we estimate CO emissions within DART/CAM-Chem using a state augmentation approach where CO emissions are added to the CO state vector being analyzed. We compare these optimized emissions to estimates derived from a traditional Bayesian synthesis inversion using the CO analyses (assimilated CO states) as observational constraints. The spatio-temporal distribution of CO and other chemical species will be compared to profile measurements from aircraft and other satellite instruments (e.g., INTEX-B, ARCTAS).

  1. Optimal estimation for global ground-level fine particulate matter concentrations

    NASA Astrophysics Data System (ADS)

    Donkelaar, Aaron; Martin, Randall V.; Spurr, Robert J. D.; Drury, Easan; Remer, Lorraine A.; Levy, Robert C.; Wang, Jun

    2013-06-01

    We develop an optimal estimation (OE) algorithm based on top-of-atmosphere reflectances observed by the MODIS satellite instrument to retrieve near-surface fine particulate matter (PM2.5). The GEOS-Chem chemical transport model is used to provide prior information for the Aerosol Optical Depth (AOD) retrieval and to relate total column AOD to PM2.5. We adjust the shape of the GEOS-Chem relative vertical extinction profiles by comparison with lidar retrievals from the CALIOP satellite instrument. Surface reflectance relationships used in the OE algorithm are indexed by land type. Error quantities needed for this OE algorithm are inferred by comparison with AOD observations taken by a worldwide network of sun photometers (AERONET) and extended globally based upon aerosol speciation and cross correlation for simulated values, and upon land type for observational values. Significant agreement in PM2.5 is found over North America for 2005 (slope = 0.89; r = 0.82; 1-σ error = 1 µg/m3 + 27%), with improved coverage and correlation relative to previous work for the same region and time period, although certain subregions, such as the San Joaquin Valley of California are better represented by previous estimates. Independently derived error estimates of the OE PM2.5 values at in situ locations over North America (of ±(2.5 µg/m3 + 31%) and Europe of ±(3.5 µg/m3 + 30%) are corroborated by comparison with in situ observations, although globally (error estimates of ±(3.0 µg/m3 + 35%), may be underestimated. Global population-weighted PM2.5 at 50% relative humidity is estimated as 27.8 µg/m3 at 0.1° × 0.1° resolution.

  2. Need for coordinated programs to improve global health by optimizing salt and iodine intake.

    PubMed

    Campbell, Norm R C; Dary, Omar; Cappuccio, Francesco P; Neufeld, Lynnette M; Harding, Kim B; Zimmermann, Michael B

    2012-10-01

    High dietary salt is a major cause of increased blood pressure, the leading risk for death worldwide. The World Health Organization (WHO) has recommended that salt intake be less than 5 g/day, a goal that only a small proportion of people achieve. Iodine deficiency can cause cognitive and motor impairment and, if severe, hypothyroidism with serious mental and growth retardation. More than 2 billion people worldwide are at risk of iodine deficiency. Preventing iodine deficiency by using salt fortified with iodine is a major global public health success. Programs to reduce dietary salt are technically compatible with programs to prevent iodine deficiency through salt fortification. However, for populations to fully benefit from optimum intake of salt and iodine, the programs must be integrated. This review summarizes the scientific basis for salt reduction and iodine fortification programs, the compatibility of the programs, and the steps that need to be taken by the WHO, national governments, and nongovernmental organizations to ensure that populations fully benefit from optimal intake of salt and iodine. Specifically, expert groups must be convened to help countries implement integrated programs and context-specific case studies of successfully integrated programs; lessons learned need to be compiled and disseminated. Integrated surveillance programs will be more efficient and will enhance current efforts to optimize intake of iodine and salt. For populations to fully benefit, governments need to place a high priority on integrating these two important public health programs. PMID:23299289

  3. A hybrid cuckoo search algorithm with Nelder Mead method for solving global optimization problems.

    PubMed

    Ali, Ahmed F; Tawhid, Mohamed A

    2016-01-01

    Cuckoo search algorithm is a promising metaheuristic population based method. It has been applied to solve many real life problems. In this paper, we propose a new cuckoo search algorithm by combining the cuckoo search algorithm with the Nelder-Mead method in order to solve the integer and minimax optimization problems. We call the proposed algorithm by hybrid cuckoo search and Nelder-Mead method (HCSNM). HCSNM starts the search by applying the standard cuckoo search for number of iterations then the best obtained solution is passing to the Nelder-Mead algorithm as an intensification process in order to accelerate the search and overcome the slow convergence of the standard cuckoo search algorithm. The proposed algorithm is balancing between the global exploration of the Cuckoo search algorithm and the deep exploitation of the Nelder-Mead method. We test HCSNM algorithm on seven integer programming problems and ten minimax problems and compare against eight algorithms for solving integer programming problems and seven algorithms for solving minimax problems. The experiments results show the efficiency of the proposed algorithm and its ability to solve integer and minimax optimization problems in reasonable time. PMID:27217988

  4. Protein structure prediction using global optimization by basin-hopping with NMR shift restraints

    NASA Astrophysics Data System (ADS)

    Hoffmann, Falk; Strodel, Birgit

    2013-01-01

    Computational methods that utilize chemical shifts to produce protein structures at atomic resolution have recently been introduced. In the current work, we exploit chemical shifts by combining the basin-hopping approach to global optimization with chemical shift restraints using a penalty function. For three peptides, we demonstrate that this approach allows us to find near-native structures from fully extended structures within 10 000 basin-hopping steps. The effect of adding chemical shift restraints is that the α and β secondary structure elements form within 1000 basin-hopping steps, after which the orientation of the secondary structure elements, which produces the tertiary contacts, is driven by the underlying protein force field. We further show that our chemical shift-restraint BH approach also works for incomplete chemical shift assignments, where the information from only one chemical shift type is considered. For the proper implementation of chemical shift restraints in the basin-hopping approach, we determined the optimal weight of the chemical shift penalty energy with respect to the CHARMM force field in conjunction with the FACTS solvation model employed in this study. In order to speed up the local energy minimization procedure, we developed a function, which continuously decreases the width of the chemical shift penalty function as the minimization progresses. We conclude that the basin-hopping approach with chemical shift restraints is a promising method for protein structure prediction.

  5. Multistage and multiobjective formulations of globally optimal upgradable expansions for electric power distribution systems

    NASA Astrophysics Data System (ADS)

    Vaziri Yazdi Pin, Mohammad

    practices. Single criterion optimization algorithms using mathematical programming for globally optimal solutions have been developed for three objectives of cost, reliability, and the social/environmental impacts. Additional algorithms for inclusions of upgrade and optimal load assignment possibilities have been developed. Algorithms have been developed to handle the expansion as a multiobjective decision process. Typical data from both major investor owned and major municipal utilities operating in California USA, have been utilized to implement and test the algorithms on practical test cases. Results of the case studies and associated analyses indicate that the developed algorithms also perform efficiently in solving the multistage and multiobjective expansion problem.

  6. Pivot method for global optimization: A study of structures and phase changes in water clusters

    NASA Astrophysics Data System (ADS)

    Nigra, Pablo Fernando

    In this thesis, we have carried out a study of water clusters. The research work has been developed in two stages. In the first stage, we have investigated the properties of water clusters at zero temperature by means of global optimization. The clusters were modeled by using two well known pairwise potentials having distinct characteristics. One is the Matsuoka-Clementi-Yoshimine potential (MCY) that is an ab initio fitted function based on a rigid-molecule model, the other is the Sillinger-Rahman potential (SR) which is an empirical function based on a flexible-molecule model. The algorithm used for the global optimization of the clusters was the pivot method, which was developed in our group. The results have shown that, under certain conditions, the pivot method may yield optimized structures which are related to one another in such a way that they seem to form structural families. The structures in a family can be thought of as formed from the aggregation of single units. The particular types of structures we have found are quasi-one dimensional tubes built from stacking cyclic units such as tetramers, pentamers, and hexamers. The binding energies of these tubes form sequences that span smooth curves with clear asymptotic behavior; therefore, we have also studied the sequences applying the Bulirsch-Stoer (BST) algorithm to accelerate convergence. In the second stage of the research work, we have studied the thermodynamic properties of a typical water cluster at finite temperatures. The selected cluster was the water octamer which exhibits a definite solid-liquid phase change. The water octamer also has several low lying energy cubic structures with large energetic barriers that cause ergodicity breaking in regular Monte Carlo simulations. For that reason we have simulated the octamer using paralell tempering Monte Carlo combined with the multihistogram method. This has permited us to calculate the heat capacity from very low temperatures up to T = 230 K. We

  7. Recursive Ant Colony Global Optimization: a new technique for the inversion of geophysical data

    NASA Astrophysics Data System (ADS)

    Gupta, D. K.; Gupta, J. P.; Arora, Y.; Singh, U. K.

    2011-12-01

    We present a new method called Recursive Ant Colony Global Optimization (RACO) technique, a modified form of general ACO, which can be used to find the best solutions to inversion problems in geophysics. RACO simulates the social behaviour of ants to find the best path between the nest and the food source. A new term depth has been introduced, which controls the extent of recursion. A selective number of cities get qualified for the successive depth. The results of one depth are used to construct the models for the next depth and the range of values for each of the parameters is reduced without any change to the number of models. The three additional steps performed after each depth, are the pheromone tracking, pheromone updating and city selection. One of the advantages of RACO over ACO is that if a problem has multiple solutions, then pheromone accumulation will take place at more than one city thereby leading to formation of multiple nested ACO loops within the ACO loop of the previous depth. Also, while the convergence of ACO is almost linear, RACO shows exponential convergence and hence is faster than the ACO. RACO proves better over some other global optimization techniques, as it does not require any initial values to be assigned to the parameters function. The method has been tested on some mathematical functions, synthetic self-potential (SP) and synthetic gravity data. The obtained results reveal the efficiency and practicability of the method. The method is found to be efficient enough to solve the problems of SP and gravity anomalies due to a horizontal cylinder, a sphere, an inclined sheet and multiple idealized bodies buried inside the earth. These anomalies with and without noise were inverted using the RACO algorithm. The obtained results were compared with those obtained from the conventional methods and it was found that RACO results are more accurate. Finally this optimization technique was applied to real field data collected over the Surda

  8. Using R for Global Optimization of a Fully-distributed Hydrologic Model at Continental Scale

    NASA Astrophysics Data System (ADS)

    Zambrano-Bigiarini, M.; Zajac, Z.; Salamon, P.

    2013-12-01

    Nowadays hydrologic model simulations are widely used to better understand hydrologic processes and to predict extreme events such as floods and droughts. In particular, the spatially distributed LISFLOOD model is currently used for flood forecasting at Pan-European scale, within the European Flood Awareness System (EFAS). Several model parameters can not be directly measured, and they need to be estimated through calibration, in order to constrain simulated discharges to their observed counterparts. In this work we describe how the free software 'R' has been used as a single environment to pre-process hydro-meteorological data, to carry out global optimization, and to post-process calibration results in Europe. Historical daily discharge records were pre-processed for 4062 stream gauges, with different amount and distribution of data in each one of them. The hydroTSM, raster and sp R packages were used to select ca. 700 stations with an adequate spatio-temporal coverage. Selected stations span a wide range of hydro-climatic characteristics, from arid and ET-dominated watersheds in the Iberian Peninsula to snow-dominated watersheds in Scandinavia. Nine parameters were selected to be calibrated based on previous expert knowledge. Customized R scripts were used to extract observed time series for each catchment and to prepare the input files required to fully set up the calibration thereof. The hydroPSO package was then used to carry out a single-objective global optimization on each selected catchment, by using the Standard Particle Swarm 2011 (SPSO-2011) algorithm. Among the many goodness-of-fit measures available in the hydroGOF package, the Nash-Sutcliffe efficiency was used to drive the optimization. User-defined functions were developed for reading model outputs and passing them to the calibration engine. The long computational time required to finish the calibration at continental scale was partially alleviated by using 4 multi-core machines (with both GNU

  9. Global parameter optimization for maximizing radioisotope detection probabilities at fixed false alarm rates

    NASA Astrophysics Data System (ADS)

    Portnoy, David; Feuerbach, Robert; Heimberg, Jennifer

    2011-10-01

    Today there is a tremendous amount of interest in systems that can detect radiological or nuclear threats. Many of these systems operate in extremely high throughput situations where delays caused by false alarms can have a significant negative impact. Thus, calculating the tradeoff between detection rates and false alarm rates is critical for their successful operation. Receiver operating characteristic (ROC) curves have long been used to depict this tradeoff. The methodology was first developed in the field of signal detection. In recent years it has been used increasingly in machine learning and data mining applications. It follows that this methodology could be applied to radiological/nuclear threat detection systems. However many of these systems do not fit into the classic principles of statistical detection theory because they tend to lack tractable likelihood functions and have many parameters, which, in general, do not have a one-to-one correspondence with the detection classes. This work proposes a strategy to overcome these problems by empirically finding parameter values that maximize the probability of detection for a selected number of probabilities of false alarm. To find these parameter values a statistical global optimization technique that seeks to estimate portions of a ROC curve is proposed. The optimization combines elements of simulated annealing with elements of genetic algorithms. Genetic algorithms were chosen because they can reduce the risk of getting stuck in local minima. However classic genetic algorithms operate on arrays of Booleans values or bit strings, so simulated annealing is employed to perform mutation in the genetic algorithm. The presented initial results were generated using an isotope identification algorithm developed at Johns Hopkins University Applied Physics Laboratory. The algorithm has 12 parameters: 4 real-valued and 8 Boolean. A simulated dataset was used for the optimization study; the "threat" set of spectra

  10. Optimizing global health experiences in emergency medicine residency programs: a consensus statement from the Council of Emergency Medicine Residency Directors 2011 Academic Assembly global health specialty track

    PubMed Central

    2012-01-01

    Background An increasing number of emergency medicine (EM) residency training programs have residents interested in participating in clinical rotations in other countries. However, the policies that each individual training program applies to this process are different. To our knowledge, little has been done in the standardization of these experiences to help EM residency programs with the evaluation, administration and implementation of a successful global health clinical elective experience. The objective of this project was to assess the current status of EM global health electives at residency training programs and to establish recommendations from educators in EM on the best methodology to implement successful global health electives. Methods During the 2011 Council of Emergency Medicine Residency Directors (CORD) Academic Assembly, participants met to address this issue in a mediated discussion session and working group. Session participants examined data previously obtained via the CORD online listserve, discussed best practices in global health applications, evaluations and partnerships, and explored possible solutions to some of the challenges. In addition a survey was sent to CORD members prior to the 2011 Academic Assembly to evaluate the resources and processes for EM residents’ global experiences. Results Recommendations included creating a global health working group within the organization, optimizing a clearinghouse of elective opportunities for residents and standardizing elective application materials, site evaluations and resident assessment/feedback methods. The survey showed that 71.4% of respondents have global health partnerships and electives. However, only 36.7% of programs require pre-departure training, and only 20% have formal competency requirements for these global health electives. Conclusions A large number of EM training programs have global health experiences available, but these electives and the trainees may benefit from

  11. Climate, Agriculture, Energy and the Optimal Allocation of Global Land Use

    NASA Astrophysics Data System (ADS)

    Steinbuks, J.; Hertel, T. W.

    2011-12-01

    The allocation of the world's land resources over the course of the next century has become a pressing research question. Continuing population increases, improving, land-intensive diets amongst the poorest populations in the world, increasing production of biofuels and rapid urbanization in developing countries are all competing for land even as the world looks to land resources to supply more environmental services. The latter include biodiversity and natural lands, as well as forests and grasslands devoted to carbon sequestration. And all of this is taking place in the context of faster than expected climate change which is altering the biophysical environment for land-related activities. The goal of the paper is to determine the optimal profile for global land use in the context of growing commercial demands for food and forest products, increasing non-market demands for ecosystem services, and more stringent GHG mitigation targets. We then seek to assess how the uncertainty associated with the underlying biophysical and economic processes influences this optimal profile of land use, in light of potential irreversibility in these decisions. We develop a dynamic long-run, forward-looking partial equilibrium framework in which the societal objective function being maximized places value on food production, liquid fuels (including biofuels), timber production, forest carbon and biodiversity. Given the importance of land-based emissions to any GHG mitigation strategy, as well as the potential impacts of climate change itself on the productivity of land in agriculture, forestry and ecosystem services, we aim to identify the optimal allocation of the world's land resources, over the course of the next century, in the face of alternative GHG constraints. The forestry sector is characterized by multiple forest vintages which add considerable computational complexity in the context of this dynamic analysis. In order to solve this model efficiently, we have employed the

  12. Optimizing Virtual Land and Water Resources Flow Through Global Trade to Meet World Food and Biofuel Demand

    NASA Astrophysics Data System (ADS)

    Zhang, X.; Cai, X.; Zhu, T.

    2013-12-01

    Biofuels is booming in recent years due to its potential contributions to energy sustainability, environmental improvement and economic opportunities. Production of biofuels not only competes for land and water with food production, but also directly pushes up food prices when crops such as maize and sugarcane are used as biofuels feedstock. Meanwhile, international trade of agricultural commodities exports and imports water and land resources in a virtual form among different regions, balances overall water and land demands and resource endowment, and provides a promising solution to the increasingly severe food-energy competition. This study investigates how to optimize water and land resources uses for overall welfare at global scale in the framework of 'virtual resources'. In contrast to partial equilibrium models that usually simulate trades year-by-year, this optimization model explores the ideal world where malnourishment is minimized with optimal resources uses and trade flows. Comparing the optimal production and trade patterns with historical data can provide meaningful implications regarding how to utilize water and land resources more efficiently and how the trade flows would be changed for overall welfare at global scale. Valuable insights are obtained in terms of the interactions among food, water and bioenergy systems. A global hydro-economic optimization model is developed, integrating agricultural production, market demands (food, feed, fuel and other), and resource and environmental constraints. Preliminary results show that with the 'free market' mechanism and land as well as water resources use optimization, the malnourished population can be reduced by as much as 65%, compared to the 2000 historical value. Expected results include: 1) optimal trade paths to achieve global malnourishment minimization, 2) how water and land resources constrain local supply, 3) how policy affects the trade pattern as well as resource uses. Furthermore, impacts of

  13. GOSIM: A multi-scale iterative multiple-point statistics algorithm with global optimization

    NASA Astrophysics Data System (ADS)

    Yang, Liang; Hou, Weisheng; Cui, Chanjie; Cui, Jie

    2016-04-01

    Most current multiple-point statistics (MPS) algorithms are based on a sequential simulation procedure, during which grid values are updated according to the local data events. Because the realization is updated only once during the sequential process, errors that occur while updating data events cannot be corrected. Error accumulation during simulations decreases the realization quality. Aimed at improving simulation quality, this study presents an MPS algorithm based on global optimization, called GOSIM. An objective function is defined for representing the dissimilarity between a realization and the TI in GOSIM, which is minimized by a multi-scale EM-like iterative method that contains an E-step and M-step in each iteration. The E-step searches for TI patterns that are most similar to the realization and match the conditioning data. A modified PatchMatch algorithm is used to accelerate the search process in E-step. M-step updates the realization based on the most similar patterns found in E-step and matches the global statistics of TI. During categorical data simulation, k-means clustering is used for transforming the obtained continuous realization into a categorical realization. The qualitative and quantitative comparison results of GOSIM, MS-CCSIM and SNESIM suggest that GOSIM has a better pattern reproduction ability for both unconditional and conditional simulations. A sensitivity analysis illustrates that pattern size significantly impacts the time costs and simulation quality. In conditional simulations, the weights of conditioning data should be as small as possible to maintain a good simulation quality. The study shows that big iteration numbers at coarser scales increase simulation quality and small iteration numbers at finer scales significantly save simulation time.

  14. Global localization of 3D anatomical structures by pre-filtered Hough forests and discrete optimization.

    PubMed

    Donner, René; Menze, Bjoern H; Bischof, Horst; Langs, Georg

    2013-12-01

    The accurate localization of anatomical landmarks is a challenging task, often solved by domain specific approaches. We propose a method for the automatic localization of landmarks in complex, repetitive anatomical structures. The key idea is to combine three steps: (1) a classifier for pre-filtering anatomical landmark positions that (2) are refined through a Hough regression model, together with (3) a parts-based model of the global landmark topology to select the final landmark positions. During training landmarks are annotated in a set of example volumes. A classifier learns local landmark appearance, and Hough regressors are trained to aggregate neighborhood information to a precise landmark coordinate position. A non-parametric geometric model encodes the spatial relationships between the landmarks and derives a topology which connects mutually predictive landmarks. During the global search we classify all voxels in the query volume, and perform regression-based agglomeration of landmark probabilities to highly accurate and specific candidate points at potential landmark locations. We encode the candidates' weights together with the conformity of the connecting edges to the learnt geometric model in a Markov Random Field (MRF). By solving the corresponding discrete optimization problem, the most probable location for each model landmark is found in the query volume. We show that this approach is able to consistently localize the model landmarks despite the complex and repetitive character of the anatomical structures on three challenging data sets (hand radiographs, hand CTs, and whole body CTs), with a median localization error of 0.80 mm, 1.19 mm and 2.71 mm, respectively. PMID:23664450

  15. Global search and optimization for free-return Earth-Mars cyclers

    NASA Astrophysics Data System (ADS)

    Russell, Ryan Paul

    A planetary cycler trajectory is a periodic orbit that shuttles a spaceship indefinitely between two or more planets, ideally using no powered maneuvers. Recently, the cycler concept has been revived as an alternative to the more traditional human-crewed Mars missions. This dissertation investigates a class of idealized Earth-Mars cyclers that are composed of Earth to Earth free-returns trajectories patched together with gravity-assisted flybys. A systematic method is presented to identify all feasible free-return trajectories following an arbitrary gravity-assisted flyby. The multiple-revolution Lambert's Problem is solved in the context of half-rev, full-rev, and generic returns. The solutions are expressed geometrically, and the resulting velocity diagram is a mission-planning tool with applications including but not limited to Earth-Mars cyclers. Two different global search methods are then developed and applied, taking advantage of all three types of free-return solutions. The first method results in twenty-four ballistic cyclers with periods of two to four synodic periods, ninety-two ballistic cyclers with periods of five or six synodic periods, and hundreds of near-ballistic cyclers. Most of the solutions are previously undocumented. The second and more generalized method only searches for the more practical cyclers with repeat times of three-synodic periods or less. This global approach uses combinatorial analysis and minimax optimization to identify 203 promising ballistic or near-ballistic mostly new cyclers. Finally, the feasibility of accurate ephemeris versions of the promising idealized cyclers is demonstrated. An efficient optimization method that utilizes analytic gradients is developed for long duration, ballistic, patched-conic trajectories with multiple flybys. The approach is applied at every step of a continuation method that transitions the simple model solutions to accurate ephemeris solutions. Hundreds of ballistic launch opportunities for

  16. Covariance and crossover matrix guided differential evolution for global numerical optimization.

    PubMed

    Li, YongLi; Feng, JinFu; Hu, JunHua

    2016-01-01

    Differential evolution (DE) is an efficient and robust evolutionary algorithm and has wide application in various science and engineering fields. DE is sensitive to the selection of mutation and crossover strategies and their associated control parameters. However, the structure and implementation of DEs are becoming more complex because of the diverse mutation and crossover strategies that use distinct parameter settings during the different stages of the evolution. A novel strategy is used in this study to improve the crossover and mutation operations. The crossover matrix, instead of a crossover operator and its control parameter CR, is proposed to implement the function of the crossover operation. Meanwhile, Gaussian distribution centers the best individuals found in each generation based on the proposed covariance matrix, which is generated between the best individual and several better individuals. Improved mutation operator based on the crossover matrix is randomly selected to generate the trial population. This operator is used to generate high-quality solutions to improve the capability of exploitation and enhance the preference of exploration. In addition, the memory population is randomly chosen from previous generation and used to control the search direction in the novel mutation strategy. Accordingly, the diversity of the population is improved. Thus, CCDE, which is a novel efficient and simple DE variant, is presented in this paper. CCDE has been tested on 30 benchmarks and 5 real-world optimization problems from the IEEE Congress on Evolutionary Computation (CEC) 2014 and CEC 2011, respectively. Experimental and statistical results demonstrate the effectiveness of CCDE for global numerical and engineering optimization. CCDE can solve the test benchmark functions and engineering problems more successfully than the other DE variants and algorithms from CEC 2014. PMID:27512635

  17. Efficiency of Pareto joint inversion of 2D geophysical data using global optimization methods

    NASA Astrophysics Data System (ADS)

    Miernik, Katarzyna; Bogacz, Adrian; Kozubal, Adam; Danek, Tomasz; Wojdyła, Marek

    2016-04-01

    Pareto joint inversion of two or more sets of data is a promising new tool of modern geophysical exploration. In the first stage of our investigation we created software enabling execution of forward solvers of two geophysical methods (2D magnetotelluric and gravity) as well as inversion with possibility of constraining solution with seismic data. In the algorithm solving MT forward solver Helmholtz's equations, finite element method and Dirichlet's boundary conditions were applied. Gravity forward solver was based on Talwani's algorithm. To limit dimensionality of solution space we decided to describe model as sets of polygons, using Sharp Boundary Interface (SBI) approach. The main inversion engine was created using Particle Swarm Optimization (PSO) algorithm adapted to handle two or more target functions and to prevent acceptance of solutions which are non - realistic or incompatible with Pareto scheme. Each inversion run generates single Pareto solution, which can be added to Pareto Front. The PSO inversion engine was parallelized using OpenMP standard, what enabled execution code for practically unlimited amount of threads at once. Thereby computing time of inversion process was significantly decreased. Furthermore, computing efficiency increases with number of PSO iterations. In this contribution we analyze the efficiency of created software solution taking under consideration details of chosen global optimization engine used as a main joint minimization engine. Additionally we study the scale of possible decrease of computational time caused by different methods of parallelization applied for both forward solvers and inversion algorithm. All tests were done for 2D magnetotelluric and gravity data based on real geological media. Obtained results show that even for relatively simple mid end computational infrastructure proposed solution of inversion problem can be applied in practice and used for real life problems of geophysical inversion and interpretation.

  18. Deterministic global optimization using space-filling curves and multiple estimates of Lipschitz and Hölder constants

    NASA Astrophysics Data System (ADS)

    Lera, Daniela; Sergeyev, Yaroslav D.

    2015-06-01

    In this paper, the global optimization problem miny∈S F (y) with S being a hyperinterval in RN and F (y) satisfying the Lipschitz condition with an unknown Lipschitz constant is considered. It is supposed that the function F (y) can be multiextremal, non-differentiable, and given as a 'black-box'. To attack the problem, a new global optimization algorithm based on the following two ideas is proposed and studied both theoretically and numerically. First, the new algorithm uses numerical approximations to space-filling curves to reduce the original Lipschitz multi-dimensional problem to a univariate one satisfying the Hölder condition. Second, the algorithm at each iteration applies a new geometric technique working with a number of possible Hölder constants chosen from a set of values varying from zero to infinity showing so that ideas introduced in a popular DIRECT method can be used in the Hölder global optimization. Convergence conditions of the resulting deterministic global optimization method are established. Numerical experiments carried out on several hundreds of test functions show quite a promising performance of the new algorithm in comparison with its direct competitors.

  19. Optimal estimation of regional N2O emissions using a three-dimensional global model

    NASA Astrophysics Data System (ADS)

    Huang, J.; Golombek, A.; Prinn, R.

    2004-12-01

    In this study, we use the MATCH (Model of Atmospheric Transport and Chemistry) model and Kalman filtering techniques to optimally estimate N2O emissions from seven source regions around the globe. The MATCH model was used with NCEP assimilated winds at T62 resolution (192 longitude by 94 latitude surface grid, and 28 vertical levels) from July 1st 1996 to December 31st 2000. The average concentrations of N2O in the lowest four layers of the model were then compared with the monthly mean observations from six national/global networks (AGAGE, CMDL (HATS), CMDL (CCGG), CSIRO, CSIR and NIES), at 48 surface sites. A 12-month-running-mean smoother was applied to both the model results and the observations, due to the fact that the model was not able to reproduce the very small observed seasonal variations. The Kalman filter was then used to solve for the time-averaged regional emissions of N2O for January 1st 1997 to June 30th 2000. The inversions assume that the model stratospheric destruction rates, which lead to a global N2O lifetime of 130 years, are correct. It also assumes normalized emission spatial distributions from each region based on previous studies. We conclude that the global N2O emission flux is about 16.2 TgN/yr, with {34.9±1.7%} from South America and Africa, {34.6±1.5%} from South Asia, {13.9±1.5%} from China/Japan/South East Asia, {8.0±1.9%} from all oceans, {6.4±1.1%} from North America and North and West Asia, {2.6±0.4%} from Europe, and {0.9±0.7%} from New Zealand and Australia. The errors here include the measurement standard deviation, calibration differences among the six groups, grid volume/measurement site mis-match errors estimated from the model, and a procedure to account approximately for the modeling errors.

  20. Signatures of a globally optimal searching strategy in the three-dimensional foraging flights of bumblebees.

    PubMed

    Lihoreau, Mathieu; Ings, Thomas C; Chittka, Lars; Reynolds, Andy M

    2016-01-01

    Simulated annealing is a powerful stochastic search algorithm for locating a global maximum that is hidden among many poorer local maxima in a search space. It is frequently implemented in computers working on complex optimization problems but until now has not been directly observed in nature as a searching strategy adopted by foraging animals. We analysed high-speed video recordings of the three-dimensional searching flights of bumblebees (Bombus terrestris) made in the presence of large or small artificial flowers within a 0.5 m(3) enclosed arena. Analyses of the three-dimensional flight patterns in both conditions reveal signatures of simulated annealing searches. After leaving a flower, bees tend to scan back-and forth past that flower before making prospecting flights (loops), whose length increases over time. The search pattern becomes gradually more expansive and culminates when another rewarding flower is found. Bees then scan back and forth in the vicinity of the newly discovered flower and the process repeats. This looping search pattern, in which flight step lengths are typically power-law distributed, provides a relatively simple yet highly efficient strategy for pollinators such as bees to find best quality resources in complex environments made of multiple ephemeral feeding sites with nutritionally variable rewards. PMID:27459948

  1. Signatures of a globally optimal searching strategy in the three-dimensional foraging flights of bumblebees

    PubMed Central

    Lihoreau, Mathieu; Ings, Thomas C.; Chittka, Lars; Reynolds, Andy M.

    2016-01-01

    Simulated annealing is a powerful stochastic search algorithm for locating a global maximum that is hidden among many poorer local maxima in a search space. It is frequently implemented in computers working on complex optimization problems but until now has not been directly observed in nature as a searching strategy adopted by foraging animals. We analysed high-speed video recordings of the three-dimensional searching flights of bumblebees (Bombus terrestris) made in the presence of large or small artificial flowers within a 0.5 m3 enclosed arena. Analyses of the three-dimensional flight patterns in both conditions reveal signatures of simulated annealing searches. After leaving a flower, bees tend to scan back-and forth past that flower before making prospecting flights (loops), whose length increases over time. The search pattern becomes gradually more expansive and culminates when another rewarding flower is found. Bees then scan back and forth in the vicinity of the newly discovered flower and the process repeats. This looping search pattern, in which flight step lengths are typically power-law distributed, provides a relatively simple yet highly efficient strategy for pollinators such as bees to find best quality resources in complex environments made of multiple ephemeral feeding sites with nutritionally variable rewards. PMID:27459948

  2. Signatures of a globally optimal searching strategy in the three-dimensional foraging flights of bumblebees

    NASA Astrophysics Data System (ADS)

    Lihoreau, Mathieu; Ings, Thomas C.; Chittka, Lars; Reynolds, Andy M.

    2016-07-01

    Simulated annealing is a powerful stochastic search algorithm for locating a global maximum that is hidden among many poorer local maxima in a search space. It is frequently implemented in computers working on complex optimization problems but until now has not been directly observed in nature as a searching strategy adopted by foraging animals. We analysed high-speed video recordings of the three-dimensional searching flights of bumblebees (Bombus terrestris) made in the presence of large or small artificial flowers within a 0.5 m3 enclosed arena. Analyses of the three-dimensional flight patterns in both conditions reveal signatures of simulated annealing searches. After leaving a flower, bees tend to scan back-and forth past that flower before making prospecting flights (loops), whose length increases over time. The search pattern becomes gradually more expansive and culminates when another rewarding flower is found. Bees then scan back and forth in the vicinity of the newly discovered flower and the process repeats. This looping search pattern, in which flight step lengths are typically power-law distributed, provides a relatively simple yet highly efficient strategy for pollinators such as bees to find best quality resources in complex environments made of multiple ephemeral feeding sites with nutritionally variable rewards.

  3. Optimal Stomatal Behaviour Around the World: Synthesis of a Global Stomatal Conductance Database and Scaling from Leaf to Ecosystem

    NASA Astrophysics Data System (ADS)

    Lin, Y. S.; Medlyn, B. E.; Duursma, R.; Prentice, I. C.; Wang, H.

    2014-12-01

    Stomatal conductance (gs) is a key land surface attribute as it links transpiration, the dominant component of global land evapotranspiration and a key element of the global water cycle, and photosynthesis, the driving force of the global carbon cycle. Despite the pivotal role of gs in predictions of global water and carbon cycles, a global scale database and an associated globally applicable model of gs that allow predictions of stomatal behaviour are lacking. We present a unique database of globally distributed gs obtained in the field for a wide range of plant functional types (PFTs) and biomes. We employed a model of optimal stomatal conductance to assess differences in stomatal behaviour, and estimated the model slope coefficient, g1, which is directly related to the marginal carbon cost of water, for each dataset. We found that g1 varies considerably among PFTs, with evergreen savanna trees having the largest g1 (least conservative water use), followed by C3 grasses and crops, angiosperm trees, gymnosperm trees, and C4 grasses. Amongst angiosperm trees, species with higher wood density had a higher marginal carbon cost of water, as predicted by the theory underpinning the optimal stomatal model. There was an interactive effect between temperature and moisture availability on g1: for wet environments, g1 was largest in high temperature environments, indicated by high mean annual temperature during the period when temperature above 0oC (Tm), but it did not vary with Tm across dry environments. We examine whether these differences in leaf-scale behaviour are reflected in ecosystem-scale differences in water-use efficiency. These findings provide a robust theoretical framework for understanding and predicting the behaviour of stomatal conductance across biomes and across PFTs that can be applied to regional, continental and global-scale modelling of productivity and ecohydrological processes in a future changing climate.

  4. A GPS-Based Pitot-Static Calibration Method Using Global Output-Error Optimization

    NASA Technical Reports Server (NTRS)

    Foster, John V.; Cunningham, Kevin

    2010-01-01

    Pressure-based airspeed and altitude measurements for aircraft typically require calibration of the installed system to account for pressure sensing errors such as those due to local flow field effects. In some cases, calibration is used to meet requirements such as those specified in Federal Aviation Regulation Part 25. Several methods are used for in-flight pitot-static calibration including tower fly-by, pacer aircraft, and trailing cone methods. In the 1990 s, the introduction of satellite-based positioning systems to the civilian market enabled new inflight calibration methods based on accurate ground speed measurements provided by Global Positioning Systems (GPS). Use of GPS for airspeed calibration has many advantages such as accuracy, ease of portability (e.g. hand-held) and the flexibility of operating in airspace without the limitations of test range boundaries or ground telemetry support. The current research was motivated by the need for a rapid and statistically accurate method for in-flight calibration of pitot-static systems for remotely piloted, dynamically-scaled research aircraft. Current calibration methods were deemed not practical for this application because of confined test range size and limited flight time available for each sortie. A method was developed that uses high data rate measurements of static and total pressure, and GPSbased ground speed measurements to compute the pressure errors over a range of airspeed. The novel application of this approach is the use of system identification methods that rapidly compute optimal pressure error models with defined confidence intervals in nearreal time. This method has been demonstrated in flight tests and has shown 2- bounds of approximately 0.2 kts with an order of magnitude reduction in test time over other methods. As part of this experiment, a unique database of wind measurements was acquired concurrently with the flight experiments, for the purpose of experimental validation of the

  5. Optimal global value of information trials: better aligning manufacturer and decision maker interests and enabling feasible risk sharing.

    PubMed

    Eckermann, Simon; Willan, Andrew R

    2013-05-01

    Risk sharing arrangements relate to adjusting payments for new health technologies given evidence of their performance over time. Such arrangements rely on prospective information regarding the incremental net benefit of the new technology, and its use in practice. However, once the new technology has been adopted in a particular jurisdiction, randomized clinical trials within that jurisdiction are likely to be infeasible and unethical in the cases where they would be most helpful, i.e. with current evidence of positive while uncertain incremental health and net monetary benefit. Informed patients in these cases would likely be reluctant to participate in a trial, preferring instead to receive the new technology with certainty. Consequently, informing risk sharing arrangements within a jurisdiction is problematic given the infeasibility of collecting prospective trial data. To overcome such problems, we demonstrate that global trials facilitate trialling post adoption, leading to more complete and robust risk sharing arrangements that mitigate the impact of costs of reversal on expected value of information in jurisdictions who adopt while a global trial is undertaken. More generally, optimally designed global trials offer distinct advantages over locally optimal solutions for decision makers and manufacturers alike: avoiding opportunity costs of delay in jurisdictions that adopt; overcoming barriers to evidence collection; and improving levels of expected implementation. Further, the greater strength and translatability of evidence across jurisdictions inherent in optimal global trial design reduces barriers to translation across jurisdictions characteristic of local trials. Consequently, efficiently designed global trials better align the interests of decision makers and manufacturers, increasing the feasibility of risk sharing and the expected strength of evidence over local trials, up until the point that current evidence is globally sufficient. PMID:23529209

  6. Geometric and electronic structure of mixed metal-semiconductor clusters from global optimization.-

    NASA Astrophysics Data System (ADS)

    Hagelberg, Frank; Wu, Jianhua

    2006-03-01

    In addition to pure metal and semiconductor clusters, hybrid species that contain both types of constituents occur at the metal-semiconductor interface. Thus, clusters of the form Cu(x)Si(y) were detected by mass spectrometry [1]. In this contribution, the geometric and energetic features of Me(m)Si(7-m) (Me=Cu and Li) clusters are discussed. The choice of these systems is motivated by the structural similarity of the pure Si(7), Li(7), and Cu(7) systems which all stabilize in D(5h) symmetry. On the other hand, Li and Cu, representing the alkali group (IA) and the noble metal group (IB) of the periodic system, are expected to display strongly differing behavior when integrated into a Si(n) cluster, resulting in different ground state geometries for the cases Me = Li and Me = Cu. Addressing this problem by means of geometry optimization requires, in view of the large number of possible atomic permutations for Me(m)Si(7-m) with 0 < m < 7, the use of a global search algorithm. Equilibrium geometries are obtained by simulated annealing within the Nose' thermostat frame. It is observed that Cu(m)Si(7-m) clusters with m < 6 tend towards ground state geometries derived from the D(5h) prototype. For Li(m)Si(7-m), the Li(m) subsystem is found to adsorb on the framework of the Si(7-m) dianion. [1] J.J. Scherer, J.B. Pau, C.P. Collier, A. O'Keefe, and R.J. Saykally, J. Chem. Phys. 103, 9187 (1995).

  7. Developments of global greenhouse gas retrieval algorithm based on Optimal Estimation Method

    NASA Astrophysics Data System (ADS)

    Kim, W. V.; Kim, J.; Lee, H.; Jung, Y.; Boesch, H.

    2013-12-01

    After the industrial revolution, atmospheric carbon dioxide concentration increased drastically over the last 250 years. It is still increasing and over than 400ppm of carbon dioxide was measured at Mauna Loa observatory for the first time which value was considered as important milestone. Therefore, understanding the source, emission, transport and sink of global carbon dioxide is unprecedentedly important. Currently, Total Carbon Column Observing Network (TCCON) is operated to observe CO2 concentration by ground base instruments. However, the number of site is very few and concentrated to Europe and North America. Remote sensing of CO2 could supplement those limitations. Greenhouse Gases Observing SATellite (GOSAT) which was launched 2009 is measuring column density of CO2 and other satellites are planned to launch in a few years. GOSAT provide valuable measurement data but its low spatial resolution and poor success rate of retrieval due to aerosol and cloud, forced the results to cover less than half of the whole globe. To improve data availability, accurate aerosol information is necessary, especially for East Asia region where the aerosol concentration is higher than other region. For the first step, we are developing CO2 retrieval algorithm based on optimal estimation method with VLIDORT the vector discrete ordinate radiative transfer model. Proto type algorithm, developed from various combinations of state vectors to find best combination of state vectors, shows appropriate result and good agreement with TCCON measurements. To reduce calculation cost low-stream interpolation is applied for model simulation and the simulation time is drastically reduced. For the further study, GOSAT CO2 retrieval algorithm will be combined with accurate GOSAT-CAI aerosol retrieval algorithm to obtain more accurate result especially for East Asia.

  8. Use of information on the manufacture of samples for the optical characterization of multilayers through a global optimization.

    PubMed

    Sancho-Parramon, Jordi; Ferré-Borrull, Josep; Bosch, Salvador; Ferrara, Maria Christina

    2003-03-01

    We present a procedure for the optical characterization of thin-film stacks from spectrophotometric data. The procedure overcomes the intrinsic limitations arising in the numerical determination of many parameters from reflectance or transmittance spectra measurements. The key point is to use all the information available from the manufacturing process in a single global optimization process. The method is illustrated by a case study of solgel applications. PMID:12638889

  9. Implementing the Global Plan to Stop TB, 2011–2015 – Optimizing Allocations and the Global Fund’s Contribution: A Scenario Projections Study

    PubMed Central

    Korenromp, Eline L.; Glaziou, Philippe; Fitzpatrick, Christopher; Floyd, Katherine; Hosseini, Mehran; Raviglione, Mario; Atun, Rifat; Williams, Brian

    2012-01-01

    Background The Global Plan to Stop TB estimates funding required in low- and middle-income countries to achieve TB control targets set by the Stop TB Partnership within the context of the Millennium Development Goals. We estimate the contribution and impact of Global Fund investments under various scenarios of allocations across interventions and regions. Methodology/Principal Findings Using Global Plan assumptions on expected cases and mortality, we estimate treatment costs and mortality impact for diagnosis and treatment for drug-sensitive and multidrug-resistant TB (MDR-TB), including antiretroviral treatment (ART) during DOTS for HIV-co-infected patients, for four country groups, overall and for the Global Fund investments. In 2015, China and India account for 24% of funding need, Eastern Europe and Central Asia (EECA) for 33%, sub-Saharan Africa (SSA) for 20%, and other low- and middle-income countries for 24%. Scale-up of MDR-TB treatment, especially in EECA, drives an increasing global TB funding need – an essential investment to contain the mortality burden associated with MDR-TB and future disease costs. Funding needs rise fastest in SSA, reflecting increasing coverage need of improved TB/HIV management, which saves most lives per dollar spent in the short term. The Global Fund is expected to finance 8–12% of Global Plan implementation costs annually. Lives saved through Global Fund TB support within the available funding envelope could increase 37% if allocations shifted from current regional demand patterns to a prioritized scale-up of improved TB/HIV treatment and secondly DOTS, both mainly in Africa − with EECA region, which has disproportionately high per-patient costs, funded from alternative resources. Conclusions/Significance These findings, alongside country funding gaps, domestic funding and implementation capacity and equity considerations, should inform strategies and policies for international donors, national governments and disease

  10. Lithological and Surface Geometry Joint Inversions Using Multi-Objective Global Optimization Methods

    NASA Astrophysics Data System (ADS)

    Lelièvre, Peter; Bijani, Rodrigo; Farquharson, Colin

    2016-04-01

    surfaces are set to a priori values. The inversion is tasked with calculating the geometry of the contact surfaces instead of some piecewise distribution of properties in a mesh. Again, no coupling measure is required and joint inversion is simplified. Both of these inverse problems involve high nonlinearity and discontinuous or non-obtainable derivatives. They can also involve the existence of multiple minima. Hence, one can not apply the standard descent-based local minimization methods used to solve typical minimum-structure inversions. Instead, we are applying Pareto multi-objective global optimization (PMOGO) methods, which generate a suite of solutions that minimize multiple objectives (e.g. data misfits and regularization terms) in a Pareto-optimal sense. Providing a suite of models, as opposed to a single model that minimizes a weighted sum of objectives, allows a more complete assessment of the possibilities and avoids the often difficult choice of how to weight each objective. While there are definite advantages to PMOGO joint inversion approaches, the methods come with significantly increased computational requirements. We are researching various strategies to ameliorate these computational issues including parallelization and problem dimension reduction.

  11. The Influence of Pump-and-Treat Problem Formulation on the Performance of a Hybrid Global-Local Optimizer

    NASA Astrophysics Data System (ADS)

    Matott, L. S.; Gray, G. A.

    2011-12-01

    Pump-and-treat systems are a common strategy for groundwater remediation, wherein a system of extraction wells is installed at an affected site to address pollutant migration. In this context, the likely performance of candidate remedial systems is often assessed using groundwater flow modeling. When linked with an optimizer, these models can be utilized to identify a least-cost system design that nonetheless satisfies remediation goals. Moreover, the resulting design problems serve as important tools in the development and testing of optimization algorithms. For example, consider EAGLS (Evolutionary Algorithm Guiding Local Search), a recently developed derivative-free simulation-optimization code that seeks to efficiently solve nonlinear problems by hybridizing local and global search techniques. The EAGLS package was designed to specifically target mixed variable problems and has a limited ability to intelligently adapt its behavior to given problem characteristics. For instance, to solve problems in which there are no discrete or integer variables, the EAGLS code defaults to a multi-start asynchronous parallel pattern search. Therefore, to better understand the behavior of EAGLS, the algorithm was applied to a representative dual-plume pump-and-treat containment problem. A series of numerical experiments were performed involving four different formulations of the underlying pump-and-treat optimization problem, namely: (1) optimization of pumping rates, given fixed number of wells at fixed locations; (2) optimization of pumping rates and locations of a fixed number of wells; (3) optimization of pumping rates and number of wells at fixed locations; and (4) optimization of pumping rates, locations, and number of wells. Comparison of the performance of the EAGLS software with alternative search algorithms across different problem formulations yielded new insights for improving the EAGLS algorithm and enhancing its adaptive behavior.

  12. Order-Constrained Solutions in K-Means Clustering: Even Better than Being Globally Optimal

    ERIC Educational Resources Information Center

    Steinley, Douglas; Hubert, Lawrence

    2008-01-01

    This paper proposes an order-constrained K-means cluster analysis strategy, and implements that strategy through an auxiliary quadratic assignment optimization heuristic that identifies an initial object order. A subsequent dynamic programming recursion is applied to optimally subdivide the object set subject to the order constraint. We show that…

  13. Dynamic multi-swarm particle swarm optimizer using parallel PC cluster systems for global optimization of large-scale multimodal functions

    NASA Astrophysics Data System (ADS)

    Fan, Shu-Kai S.; Chang, Ju-Ming

    2010-05-01

    This article presents a novel parallel multi-swarm optimization (PMSO) algorithm with the aim of enhancing the search ability of standard single-swarm PSOs for global optimization of very large-scale multimodal functions. Different from the existing multi-swarm structures, the multiple swarms work in parallel, and the search space is partitioned evenly and dynamically assigned in a weighted manner via the roulette wheel selection (RWS) mechanism. This parallel, distributed framework of the PMSO algorithm is developed based on a master-slave paradigm, which is implemented on a cluster of PCs using message passing interface (MPI) for information interchange among swarms. The PMSO algorithm handles multiple swarms simultaneously and each swarm performs PSO operations of its own independently. In particular, one swarm is designated for global search and the others are for local search. The first part of the experimental comparison is made among the PMSO, standard PSO, and two state-of-the-art algorithms (CTSS and CLPSO) in terms of various un-rotated and rotated benchmark functions taken from the literature. In the second part, the proposed multi-swarm algorithm is tested on large-scale multimodal benchmark functions up to 300 dimensions. The results of the PMSO algorithm show great promise in solving high-dimensional problems.

  14. PANMIN: sequential and parallel global optimization procedures with a variety of options for the local search strategy

    NASA Astrophysics Data System (ADS)

    Theos, F. V.; Lagaris, I. E.; Papageorgiou, D. G.

    2004-05-01

    We present two sequential and one parallel global optimization codes, that belong to the stochastic class, and an interface routine that enables the use of the Merlin/MCL environment as a non-interactive local optimizer. This interface proved extremely important, since it provides flexibility, effectiveness and robustness to the local search task that is in turn employed by the global procedures. We demonstrate the use of the parallel code to a molecular conformation problem. Program summaryTitle of program: PANMIN Catalogue identifier: ADSU Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADSU Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computer for which the program is designed and others on which it has been tested: PANMIN is designed for UNIX machines. The parallel code runs on either shared memory architectures or on a distributed system. The code has been tested on a SUN Microsystems ENTERPRISE 450 with four CPUs, and on a 48-node cluster under Linux, with both the GNU g77 and the Portland group compilers. The parallel implementation is based on MPI and has been tested with LAM MPI and MPICH Installation: University of Ioannina, Greece Programming language used: Fortran-77 Memory required to execute with typical data: Approximately O( n2) words, where n is the number of variables No. of bits in a word: 64 No. of processors used: 1 or many Has the code been vectorised or parallelized?: Parallelized using MPI No. of bytes in distributed program, including test data, etc.: 147163 No. of lines in distributed program, including the test data, etc.: 14366 Distribution format: gzipped tar file Nature of physical problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques can be

  15. Optimizing Quality of Care and Patient Safety in Malaysia: The Current Global Initiatives, Gaps and Suggested Solutions

    PubMed Central

    Jarrar, Mu’taman; Rahman, Hamzah Abdul; Don, Mohammad Sobri

    2016-01-01

    Background and Objective: Demand for health care service has significantly increased, while the quality of healthcare and patient safety has become national and international priorities. This paper aims to identify the gaps and the current initiatives for optimizing the quality of care and patient safety in Malaysia. Design: Review of the current literature. Highly cited articles were used as the basis to retrieve and review the current initiatives for optimizing the quality of care and patient safety. The country health plan of Ministry of Health (MOH) Malaysia and the MOH Malaysia Annual Reports were reviewed. Results: The MOH has set four strategies for optimizing quality and sustaining quality of life. The 10th Malaysia Health Plan promotes the theme “1 Care for 1 Malaysia” in order to sustain the quality of care. Despite of these efforts, the total number of complaints received by the medico-legal section of the MOH Malaysia is increasing. The current global initiatives indicted that quality performance generally belong to three main categories: patient; staffing; and working environment related factors. Conclusions: There is no single intervention for optimizing quality of care to maintain patient safety. Multidimensional efforts and interventions are recommended in order to optimize the quality of care and patient safety in Malaysia. PMID:26755459

  16. Handling time-expensive global optimization problems through the surrogate-enhanced evolutionary annealing-simplex algorithm

    NASA Astrophysics Data System (ADS)

    Tsoukalas, Ioannis; Kossieris, Panagiotis; Efstratiadis, Andreas; Makropoulos, Christos

    2015-04-01

    In water resources optimization problems, the calculation of the objective function usually presumes to first run a simulation model and then evaluate its outputs. In several cases, however, long simulation times may pose significant barriers to the optimization procedure. Often, to obtain a solution within a reasonable time, the user has to substantially restrict the allowable number of function evaluations, thus terminating the search much earlier than required by the problem's complexity. A promising novel strategy to address these shortcomings is the use of surrogate modelling techniques within global optimization algorithms. Here we introduce the Surrogate-Enhanced Evolutionary Annealing-Simplex (SE-EAS) algorithm that couples the strengths of surrogate modelling with the effectiveness and efficiency of the EAS method. The algorithm combines three different optimization approaches (evolutionary search, simulated annealing and the downhill simplex search scheme), in which key decisions are partially guided by numerical approximations of the objective function. The performance of the proposed algorithm is benchmarked against other surrogate-assisted algorithms, in both theoretical and practical applications (i.e. test functions and hydrological calibration problems, respectively), within a limited budget of trials (from 100 to 1000). Results reveal the significant potential of using SE-EAS in challenging optimization problems, involving time-consuming simulations.

  17. Mutation-Based Artificial Fish Swarm Algorithm for Bound Constrained Global Optimization

    NASA Astrophysics Data System (ADS)

    Rocha, Ana Maria A. C.; Fernandes, Edite M. G. P.

    2011-09-01

    The herein presented mutation-based artificial fish swarm (AFS) algorithm includes mutation operators to prevent the algorithm to falling into local solutions, diversifying the search, and to accelerate convergence to the global optima. Three mutation strategies are introduced into the AFS algorithm to define the trial points that emerge from random, leaping and searching behaviors. Computational results show that the new algorithm outperforms other well-known global stochastic solution methods.

  18. Cuckoo Search with Lévy Flights for Weighted Bayesian Energy Functional Optimization in Global-Support Curve Data Fitting

    PubMed Central

    Gálvez, Akemi; Iglesias, Andrés; Cabellos, Luis

    2014-01-01

    The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way. PMID:24977175

  19. Cuckoo search with Lévy flights for weighted Bayesian energy functional optimization in global-support curve data fitting.

    PubMed

    Gálvez, Akemi; Iglesias, Andrés; Cabellos, Luis

    2014-01-01

    The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way. PMID:24977175

  20. Preliminary Analysis of Low-Thrust Gravity Assist Trajectories by An Inverse Method and a Global Optimization Technique.

    NASA Astrophysics Data System (ADS)

    de Pascale, P.; Vasile, M.; Casotto, S.

    The design of interplanetary trajectories requires the solution of an optimization problem, which has been traditionally solved by resorting to various local optimization techniques. All such approaches, apart from the specific method employed (direct or indirect), require an initial guess, which deeply influences the convergence to the optimal solution. The recent developments in low-thrust propulsion have widened the perspectives of exploration of the Solar System, while they have at the same time increased the difficulty related to the trajectory design process. Continuous thrust transfers, typically characterized by multiple spiraling arcs, have a broad number of design parameters and thanks to the flexibility offered by such engines, they typically turn out to be characterized by a multi-modal domain, with a consequent larger number of optimal solutions. Thus the definition of the first guesses is even more challenging, particularly for a broad search over the design parameters, and it requires an extensive investigation of the domain in order to locate the largest number of optimal candidate solutions and possibly the global optimal one. In this paper a tool for the preliminary definition of interplanetary transfers with coast-thrust arcs and multiple swing-bys is presented. Such goal is achieved combining a novel methodology for the description of low-thrust arcs, with a global optimization algorithm based on a hybridization of an evolutionary step and a deterministic step. Low thrust arcs are described in a 3D model in order to account the beneficial effects of low-thrust propulsion for a change of inclination, resorting to a new methodology based on an inverse method. The two-point boundary values problem (TPBVP) associated with a thrust arc is solved by imposing a proper parameterized evolution of the orbital parameters, by which, the acceleration required to follow the given trajectory with respect to the constraints set is obtained simply through

  1. In the era of global optimization, the understanding of aberrations remains the key to designing superior optical systems

    NASA Astrophysics Data System (ADS)

    Bentley, Julie L.; Olson, Craig; Youngworth, Richard N.

    2010-11-01

    Historically, a thorough grounding in aberration theory was the only path to successful lens design, both for developing starting layouts and for design improvement. Modern global optimizers, however, allow the lens designer to easily generate multiple solutions to a single design problem without understanding the crucial importance of aberrations and how they determine the full design potential. Compared to pure numerical optimization, aberration theory applied during the lens design process gives the designer a much firmer grasp of the overall design limitations and possibilities. Among other benefits, aberrations provide excellent insight into tolerance sensitivity and manufacturability of the underlying design form. We explore multiple examples of how applying aberration theory to lens design can improve the entire lens design process. Example systems include simple UV, visible, and IR refractive lenses; much more complicated refractive systems requiring field curvature balance; and broadband zoom lenses.

  2. Optimizing thermal conductivity in functionalized macromolecules using Langevin dynamics and the globalized and bounded Nelder-Mead algorithm.

    PubMed

    Ait Moussa, Abdellah; Jassemnejad, Bahaeddin

    2014-05-01

    Nanocomposites with high-aspect ratio fillers attract enormous attention because of the superior physical properties of the composite over the parent matrix. Nanocomposites with functionalized graphene as fillers did not produce the high thermal conductivity expected due to the high interfacial thermal resistance between the functional groups and graphene flakes. We report here a robust and efficient technique that identifies the configuration of the functionalities for improved thermal conductivity. The method combines linearization of the interatomic interactions, calculation, and optimization of the thermal conductivity using the globalized and bounded Nelder-Mead algorithm. PMID:25353920

  3. Optimizing thermal conductivity in functionalized macromolecules using Langevin dynamics and the globalized and bounded Nelder-Mead algorithm

    NASA Astrophysics Data System (ADS)

    Ait moussa, Abdellah; Jassemnejad, Bahaeddin

    2014-05-01

    Nanocomposites with high-aspect ratio fillers attract enormous attention because of the superior physical properties of the composite over the parent matrix. Nanocomposites with functionalized graphene as fillers did not produce the high thermal conductivity expected due to the high interfacial thermal resistance between the functional groups and graphene flakes. We report here a robust and efficient technique that identifies the configuration of the functionalities for improved thermal conductivity. The method combines linearization of the interatomic interactions, calculation, and optimization of the thermal conductivity using the globalized and bounded Nelder-Mead algorithm.

  4. Global nonlinear kernel prediction for large data set with a particle swarm-optimized interval support vector regression.

    PubMed

    Ding, Yongsheng; Cheng, Lijun; Pedrycz, Witold; Hao, Kuangrong

    2015-10-01

    A new global nonlinear predictor with a particle swarm-optimized interval support vector regression (PSO-ISVR) is proposed to address three issues (viz., kernel selection, model optimization, kernel method speed) encountered when applying SVR in the presence of large data sets. The novel prediction model can reduce the SVR computing overhead by dividing input space and adaptively selecting the optimized kernel functions to obtain optimal SVR parameter by PSO. To quantify the quality of the predictor, its generalization performance and execution speed are investigated based on statistical learning theory. In addition, experiments using synthetic data as well as the stock volume weighted average price are reported to demonstrate the effectiveness of the developed models. The experimental results show that the proposed PSO-ISVR predictor can improve the computational efficiency and the overall prediction accuracy compared with the results produced by the SVR and other regression methods. The proposed PSO-ISVR provides an important tool for nonlinear regression analysis of big data. PMID:25974954

  5. Multi-objective global optimization of a butterfly valve using genetic algorithms.

    PubMed

    Corbera, Sergio; Olazagoitia, José Luis; Lozano, José Antonio

    2016-07-01

    A butterfly valve is a type of valve typically used for isolating or regulating flow where the closing mechanism takes the form of a disc. For a long time, the attention of many researchers has focused on carrying out structural (FEM) and computational fluid dynamics (CFD) analysis in order to increase the performance of this type of flow-control device. This paper proposes a novel multi-objective approach for the design optimization of a butterfly valve using advanced genetic algorithms based on Pareto dominance. Firstly, after defining the need for this study and analyzing previous papers on the subject, the initial butterfly valve is presented and the initial fluid and structural analysis are carried out. Secondly, the optimization problem is defined and the optimization strategy is presented. The design variables are identified and a parameterization model of the valve is made. Thirdly, initial design candidates are generated by DOE and design optimization using genetic algorithms is performed. In this part of the process structural and CFD analysis are calculated for each candidate simultaneously. The optimization process involves various types of software and Python scripts are needed for their interaction and the connection of all steps. Finally, a set of optimal solutions is obtained and the optimum design that provides a 65.4% stress reduction, a 5% mass reduction and a 11.3% flow increase is selected in accordance with manufacturer preferences. Validation of the results is provided by comparing experimental test results with the values obtained for the initial design. The results demonstrate the capability and potential of the proposed methodology. PMID:27056745

  6. An Effective Hybrid Firefly Algorithm with Harmony Search for Global Numerical Optimization

    PubMed Central

    Guo, Lihong; Wang, Gai-Ge; Wang, Heqi; Wang, Dinan

    2013-01-01

    A hybrid metaheuristic approach by hybridizing harmony search (HS) and firefly algorithm (FA), namely, HS/FA, is proposed to solve function optimization. In HS/FA, the exploration of HS and the exploitation of FA are fully exerted, so HS/FA has a faster convergence speed than HS and FA. Also, top fireflies scheme is introduced to reduce running time, and HS is utilized to mutate between fireflies when updating fireflies. The HS/FA method is verified by various benchmarks. From the experiments, the implementation of HS/FA is better than the standard FA and other eight optimization methods. PMID:24348137

  7. Global Optimization of Interplanetary Trajectories in the Presence of Realistic Mission Constraints

    NASA Technical Reports Server (NTRS)

    Hinckley, David; Englander, Jacob; Hitt, Darren

    2015-01-01

    Single trial evaluations Trial creation by Phase-wise GA-style or DE-inspired recombination Bin repository structure requires an initialization period Non-exclusionary Kill Distance Population collapse mechanic Main loop Creation Probabilistic switch between GA and DE creation types Locally optimize Submit to repository Repeat.

  8. Daily Time Step Refinement of Optimized Flood Control Rule Curves for a Global Warming Scenario

    NASA Astrophysics Data System (ADS)

    Lee, S.; Fitzgerald, C.; Hamlet, A. F.; Burges, S. J.

    2009-12-01

    Pacific Northwest temperatures have warmed by 0.8 °C since 1920 and are predicted to further increase in the 21st century. Simulated streamflow timing shifts associated with climate change have been found in past research to degrade water resources system performance in the Columbia River Basin when using existing system operating policies. To adapt to these hydrologic changes, optimized flood control operating rule curves were developed in a previous study using a hybrid optimization-simulation approach which rebalanced flood control and reservoir refill at a monthly time step. For the climate change scenario, use of the optimized flood control curves restored reservoir refill capability without increasing flood risk. Here we extend the earlier studies using a detailed daily time step simulation model applied over a somewhat smaller portion of the domain (encompassing Libby, Duncan, and Corra Linn dams, and Kootenai Lake) to evaluate and refine the optimized flood control curves derived from monthly time step analysis. Moving from a monthly to daily analysis, we found that the timing of flood control evacuation needed adjustment to avoid unintended outcomes affecting Kootenai Lake. We refined the flood rule curves derived from monthly analysis by creating a more gradual evacuation schedule, but kept the timing and magnitude of maximum evacuation the same as in the monthly analysis. After these refinements, the performance at monthly time scales reported in our previous study proved robust at daily time scales. Due to a decrease in July storage deficits, additional benefits such as more revenue from hydropower generation and more July and August outflow for fish augmentation were observed when the optimized flood control curves were used for the climate change scenario.

  9. A comparison of global optimization algorithms with standard benchmark functions and real-world applications using Energy Plus

    SciTech Connect

    Kamph, Jerome Henri; Robinson, Darren; Wetter, Michael

    2009-09-01

    There is an increasing interest in the use of computer algorithms to identify combinations of parameters which optimise the energy performance of buildings. For such problems, the objective function can be multi-modal and needs to be approximated numerically using building energy simulation programs. As these programs contain iterative solution algorithms, they introduce discontinuities in the numerical approximation to the objective function. Metaheuristics often work well for such problems, but their convergence to a global optimum cannot be established formally. Moreover, different algorithms tend to be suited to particular classes of optimization problems. To shed light on this issue we compared the performance of two metaheuristics, the hybrid CMA-ES/HDE and the hybrid PSO/HJ, in minimizing standard benchmark functions and real-world building energy optimization problems of varying complexity. From this we find that the CMA-ES/HDE performs well on more complex objective functions, but that the PSO/HJ more consistently identifies the global minimum for simpler objective functions. Both identified similar values in the objective functions arising from energy simulations, but with different combinations of model parameters. This may suggest that the objective function is multi-modal. The algorithms also correctly identified some non-intuitive parameter combinations that were caused by a simplified control sequence of the building energy system that does not represent actual practice, further reinforcing their utility.

  10. MEIGO: an open-source software suite based on metaheuristics for global optimization in systems biology and bioinformatics

    PubMed Central

    2014-01-01

    Background Optimization is the key to solving many problems in computational biology. Global optimization methods, which provide a robust methodology, and metaheuristics in particular have proven to be the most efficient methods for many applications. Despite their utility, there is a limited availability of metaheuristic tools. Results We present MEIGO, an R and Matlab optimization toolbox (also available in Python via a wrapper of the R version), that implements metaheuristics capable of solving diverse problems arising in systems biology and bioinformatics. The toolbox includes the enhanced scatter search method (eSS) for continuous nonlinear programming (cNLP) and mixed-integer programming (MINLP) problems, and variable neighborhood search (VNS) for Integer Programming (IP) problems. Additionally, the R version includes BayesFit for parameter estimation by Bayesian inference. The eSS and VNS methods can be run on a single-thread or in parallel using a cooperative strategy. The code is supplied under GPLv3 and is available at http://www.iim.csic.es/~gingproc/meigo.html. Documentation and examples are included. The R package has been submitted to BioConductor. We evaluate MEIGO against optimization benchmarks, and illustrate its applicability to a series of case studies in bioinformatics and systems biology where it outperforms other state-of-the-art methods. Conclusions MEIGO provides a free, open-source platform for optimization that can be applied to multiple domains of systems biology and bioinformatics. It includes efficient state of the art metaheuristics, and its open and modular structure allows the addition of further methods. PMID:24885957

  11. A global earthquake discrimination scheme to optimize ground-motion prediction equation selection

    USGS Publications Warehouse

    Garcia, Daniel; Wald, David J.; Hearne, Michael

    2012-01-01

    We present a new automatic earthquake discrimination procedure to determine in near-real time the tectonic regime and seismotectonic domain of an earthquake, its most likely source type, and the corresponding ground-motion prediction equation (GMPE) class to be used in the U.S. Geological Survey (USGS) Global ShakeMap system. This method makes use of the Flinn–Engdahl regionalization scheme, seismotectonic information (plate boundaries, global geology, seismicity catalogs, and regional and local studies), and the source parameters available from the USGS National Earthquake Information Center in the minutes following an earthquake to give the best estimation of the setting and mechanism of the event. Depending on the tectonic setting, additional criteria based on hypocentral depth, style of faulting, and regional seismicity may be applied. For subduction zones, these criteria include the use of focal mechanism information and detailed interface models to discriminate among outer-rise, upper-plate, interface, and intraslab seismicity. The scheme is validated against a large database of recent historical earthquakes. Though developed to assess GMPE selection in Global ShakeMap operations, we anticipate a variety of uses for this strategy, from real-time processing systems to any analysis involving tectonic classification of sources from seismic catalogs.

  12. Optimized discrete wavelet transforms in the cubed sphere with the lifting scheme—implications for global finite-frequency tomography

    NASA Astrophysics Data System (ADS)

    Chevrot, Sébastien; Martin, Roland; Komatitsch, Dimitri

    2012-12-01

    Wavelets are extremely powerful to compress the information contained in finite-frequency sensitivity kernels and tomographic models. This interesting property opens the perspective of reducing the size of global tomographic inverse problems by one to two orders of magnitude. However, introducing wavelets into global tomographic problems raises the problem of computing fast wavelet transforms in spherical geometry. Using a Cartesian cubed sphere mapping, which grids the surface of the sphere with six blocks or 'chunks', we define a new algorithm to implement fast wavelet transforms with the lifting scheme. This algorithm is simple and flexible, and can handle any family of discrete orthogonal or bi-orthogonal wavelets. Since wavelet coefficients are local in space and scale, aliasing effects resulting from a parametrization with global functions such as spherical harmonics are avoided. The sparsity of tomographic models expanded in wavelet bases implies that it is possible to exploit the power of compressed sensing to retrieve Earth's internal structures optimally. This approach involves minimizing a combination of a ℓ2 norm for data residuals and a ℓ1 norm for model wavelet coefficients, which can be achieved through relatively minor modifications of the algorithms that are currently used to solve the tomographic inverse problem.

  13. Global optimal vaccination in the SIR model: properties of the value function and application to cost-effectiveness analysis.

    PubMed

    Laguzet, Laetitia; Turinici, Gabriel

    2015-05-01

    This work focuses on optimal vaccination policies for an Susceptible-Infected-Recovered (SIR) model; the impact of the disease is minimized with respect to the vaccination strategy. The problem is formulated as an optimal control problem and we show that the value function is the unique viscosity solution of an Hamilton-Jacobi-Bellman (HJB) equation. This allows to find the best vaccination policy. At odds with existing literature, it is seen that the value function is not always smooth (sometimes only Lipschitz) and the optimal vaccination policies are not unique. Moreover we rigorously analyze the situation when vaccination can be modeled as instantaneous (with respect to the time evolution of the epidemic) and identify the global optimum solutions. Numerical applications illustrate the theoretical results. In addition the pertussis vaccination in adults is considered from two perspectives: first the maximization of DALY averted in presence of vaccine side-effects; then the impact of the herd immunity on the cost-effectiveness analysis is discussed on a concrete example. PMID:25771436

  14. Optimizing learning and quality of life throughout the lifespan: a global framework for research and application.

    PubMed

    Loizzo, Joseph

    2009-08-01

    This overview surveys the new optimism about the aging mind/brain, focusing on the potential for self-regulation practices to advance research in stress-protection and optimal health. It reviews recent findings and offers a research framework. The review links the age-related biology of stress and regeneration to the variability of mind/brain function found under a range of conditions from trauma to enrichment. The framework maps this variation along a biphasic continuum from atrophic dysfunction to peak performance. It adopts the concept of allostatic load as a measure of the wear-and-tear caused by stress, and environmental enrichment as a measure of the use-dependent enhancement caused by positive reinforcement. It frames the dissociation, aversive affect and stereotyped reactions linked with stress as cognitive, affective and behavioral forms of allostatic drag; and the association, positive affect, and creative responses in enrichment as forms of allostatic lift. It views the human mind/brain as a heterarchy of higher intelligence systems that shift between a conservative, egocentric mode heightening self-preservation and memory and a generative, altruistic mode heightening self-correction and learning. Cultural practices like meditation and psychotherapy work by teaching the self-regulation of shifts from the conservative to the generative mode. This involves a systems shift from allostatic drag to allostatic lift, minimizing wear-and-tear and optimizing plasticity and learning. For cultural practices to speed research and application, a universal typology is needed. This framework includes a typology aligning current brain models of stress and learning with traditional Indo-Tibetan models of meditative stress-cessation and learning enrichment. PMID:19743554

  15. Optimization of semi-global stereo matching for hardware module implementation

    NASA Astrophysics Data System (ADS)

    Roszkowski, Mikołaj

    2014-11-01

    Stereo vision is one of the most intensively studied areas in the field of computer vision. It allows the creation of a 3D model of a scene given two images of the scene taken with optical cameras. Although the number of stereo algorithms keeps increasing, not many are suitable candidates for hardware implementations that could guarantee real-time processing in embedded systems. One of such algorithms is semi-global matching, which seems to balance well the quality of the disparity map and computational complexity. However, it still has quite high memory requirements, which can be a problem if the low-cost FPGAs are to be used. This is because they often suffer from a low external DRAM memory throughput. In this article, a few methods to reduce both the semi-global matching algorithm complexity and memory usage, and thus required bandwidth, are proposed. First of all, it is shown that a simple pyramid matching scheme can be used to efficiently reduce the number of disparities checked per pixel. Secondly, a method of dividing the image into independent blocks is proposed, which allows the reduction of the amount of memories required by the algorithm. Finally the exact requirements for the bandwidth and the size of the on-chip memories are given.

  16. Optimal integer resolution for attitude determination using global positioning system signals

    NASA Technical Reports Server (NTRS)

    Crassidis, John L.; Markley, F. Landis; Lightsey, E. Glenn

    1998-01-01

    In this paper, a new motion-based algorithm for GPS integer ambiguity resolution is derived. The first step of this algorithm converts the reference sightline vectors into body frame vectors. This is accomplished by an optimal vectorized transformation of the phase difference measurements. The result of this transformation leads to the conversion of the integer ambiguities to vectorized biases. This essentially converts the problem to the familiar magnetometer-bias determination problem, for which an optimal and efficient solution exists. Also, the formulation in this paper is re-derived to provide a sequential estimate, so that a suitable stopping condition can be found during the vehicle motion. The advantages of the new algorithm include: it does not require an a-priori estimate of the vehicle's attitude; it provides an inherent integrity check using a covariance-type expression; and it can sequentially estimate the ambiguities during the vehicle motion. The only disadvantage of the new algorithm is that it requires at least three non-coplanar baselines. The performance of the new algorithm is tested on a dynamic hardware simulator.

  17. Bayesian Segmentation of Atrium Wall Using Globally-Optimal Graph Cuts on 3D Meshes

    PubMed Central

    Veni, Gopalkrishna; Fu, Zhisong; Awate, Suyash P.; Whitaker, Ross T.

    2014-01-01

    Efficient segmentation of the left atrium (LA) wall from delayed enhancement MRI is challenging due to inconsistent contrast, combined with noise, and high variation in atrial shape and size. We present a surface-detection method that is capable of extracting the atrial wall by computing an optimal a-posteriori estimate. This estimation is done on a set of nested meshes, constructed from an ensemble of segmented training images, and graph cuts on an associated multi-column, proper-ordered graph. The graph/mesh is a part of a template/model that has an associated set of learned intensity features. When this mesh is overlaid onto a test image, it produces a set of costs which lead to an optimal segmentation. The 3D mesh has an associated weighted, directed multi-column graph with edges that encode smoothness and inter-surface penalties. Unlike previous graph-cut methods that impose hard constraints on the surface properties, the proposed method follows from a Bayesian formulation resulting in soft penalties on spatial variation of the cuts through the mesh. The novelty of this method also lies in the construction of proper-ordered graphs on complex shapes for choosing among distinct classes of base shapes for automatic LA segmentation. We evaluate the proposed segmentation framework on simulated and clinical cardiac MRI. PMID:24684007

  18. Towards continuous global measurements and optimal emission estimates of NF3

    NASA Astrophysics Data System (ADS)

    Arnold, T.; Muhle, J.; Salameh, P.; Harth, C.; Ivy, D. J.; Weiss, R. F.

    2011-12-01

    We present an analytical method for the continuous in situ measurement of nitrogen trifluoride (NF3) - an anthropogenic gas with a global warming potential of ~16800 over a 100 year time horizon. NF3 is not included in national reporting emissions inventories under the United Nations Framework Convention on Climate Change (UNFCCC). However, it is a rapidly emerging greenhouse gas due to emission from a growing number of manufacturing facilities with increasing output and modern end-use applications, namely in microcircuit etching, and in production of flat panel displays and thin-film photovoltaic cells. Despite success in measuring the most volatile long lived halogenated species such as CF4, the Medusa preconcentration GC/MS system of Miller et al. (2008) is unable to detect NF3 under remote operation. Using altered techniques of gas separation and chromatography after initial preconcentration, we are now able to make continuous atmospheric measurements of NF3 with average precisions < 1.5% (1 s.d.) for modern background air samples. Most notably, the suite of gases previously measured by Medusa (the significant halogenated species listed under both the Montreal and Kyoto Protocols), can also be quantified from the same sample. Our technique was used to extend the most recent atmospheric measurements into 2011 and complete the background Southern Hemispheric trend over the past three decades using samples from the Cape Grim Air Archive. Using these latest results and those from Weiss et al. (2008) we present optimised annual emission estimates using a 2D atmospheric transport model (AGAGE 12-box model) and an inverse method (Rigby et al., 2011). We calculate emissions during 2010 of 7.6 +/- 1.3 kt (equivalent to 13 million metric tons of CO2), which is estimated to be around 6% of the total NF3 produced. Emission factors are shown to have reduced over the last decade; however, rising production and end-use have caused the average global atmospheric concentration

  19. Optimizing Global Coronal Magnetic Field Models Using Image-based Constraints

    NASA Astrophysics Data System (ADS)

    Jones, Shaela I.; Davila, Joseph M.; Uritsky, Vadim

    2016-04-01

    The coronal magnetic field directly or indirectly affects a majority of the phenomena studied in the heliosphere. It provides energy for coronal heating, controls the release of coronal mass ejections, and drives heliospheric and magnetospheric activity, yet the coronal magnetic field itself has proven difficult to measure. This difficulty has prompted a decades-long effort to develop accurate, timely, models of the field—an effort that continues today. We have developed a method for improving global coronal magnetic field models by incorporating the type of morphological constraints that could be derived from coronal images. Here we report promising initial tests of this approach on two theoretical problems, and discuss opportunities for application.

  20. Recent improvements in prediction of protein structure by global optimization of a potential energy function

    PubMed Central

    Pillardy, Jarosław; Czaplewski, Cezary; Liwo, Adam; Lee, Jooyoung; Ripoll, Daniel R.; Kaźmierkiewicz, Rajmund; Ołdziej, Stanisław; Wedemeyer, William J.; Gibson, Kenneth D.; Arnautova, Yelena A.; Saunders, Jeff; Ye, Yuan-Jie; Scheraga, Harold A.

    2001-01-01

    Recent improvements of a hierarchical ab initio or de novo approach for predicting both α and β structures of proteins are described. The united-residue energy function used in this procedure includes multibody interactions from a cumulant expansion of the free energy of polypeptide chains, with their relative weights determined by Z-score optimization. The critical initial stage of the hierarchical procedure involves a search of conformational space by the conformational space annealing (CSA) method, followed by optimization of an all-atom model. The procedure was assessed in a recent blind test of protein structure prediction (CASP4). The resulting lowest-energy structures of the target proteins (ranging in size from 70 to 244 residues) agreed with the experimental structures in many respects. The entire experimental structure of a cyclic α-helical protein of 70 residues was predicted to within 4.3 Å α-carbon (Cα) rms deviation (rmsd) whereas, for other α-helical proteins, fragments of roughly 60 residues were predicted to within 6.0 Å Cα rmsd. Whereas β structures can now be predicted with the new procedure, the success rate for α/β- and β-proteins is lower than that for α-proteins at present. For the β portions of α/β structures, the Cα rmsd's are less than 6.0 Å for contiguous fragments of 30–40 residues; for one target, three fragments (of length 10, 23, and 28 residues, respectively) formed a compact part of the tertiary structure with a Cα rmsd less than 6.0 Å. Overall, these results constitute an important step toward the ab initio prediction of protein structure solely from the amino acid sequence. PMID:11226239

  1. Demodulation of two-shot fringe patterns with random phase shifts by use of orthogonal polynomials and global optimization.

    PubMed

    Tian, Chao; Liu, Shengchun

    2016-02-22

    We propose a simple and robust phase demodulation algorithm for two-shot fringe patterns with random phase shifts. Based on a smoothness assumption, the phase to be recovered is decomposed into a linear combination of finite terms of orthogonal polynomials, and the expansion coefficients and the phase shift are exhaustively searched through global optimization. The technique is insensitive to noise or defects, and is capable of retrieving phase from low fringe-number (less than one) or low-frequency interferograms. It can also cope with interferograms with very small phase shifts. The retrieved phase is continuous and no further phase unwrapping process is required. The method is expected to be promising to process interferograms with regular fringes, which are common in optical shop testing. Computer simulation and experimental results are presented to demonstrate the performance of the algorithm. PMID:26906984

  2. Ab initio global optimization of the structures of Si{sub n}H, n=4-10, using parallel genetic algorithms

    SciTech Connect

    Ona, Ofelia; Facelli, Julio C.; Bazterra, Victor E.; Caputo, Maria C.; Ferraro, Marta B.

    2005-11-15

    The results of ab initio global optimizations of the structures of Si{sub n}H, n=4-10, atomic clusters using a parallel genetic algorithm are presented. Driving the global search with the parallel implementation of the genetic algorithm are presented and using the density functional theory as implemented in the Carr-Parinello molecular dynamics code to calculate atomic cluster energies and perform the local optimization of their structures, we have been able to demonstrate that it is possible to perform global optimizations of the structure of atomic clusters using ab initio methods. The results show that this approach is able to find many structures that were not previously reported in the literature. Moreover, in most cases the new structures have considerable lower energies than those previously known. The results clearly demonstrate that these calculations are now possible and in spite of their larger computational demands provide more reliable results.

  3. Measuring resetting of brain dynamics at epileptic seizures: application of global optimization and spatial synchronization techniques.

    PubMed

    Sabesan, Shivkumar; Chakravarthy, Niranjan; Tsakalis, Kostas; Pardalos, Panos; Iasemidis, Leon

    2009-01-01

    Epileptic seizures are manifestations of intermittent spatiotemporal transitions of the human brain from chaos to order. Measures of chaos, namely maximum Lyapunov exponents (STL(max)), from dynamical analysis of the electroencephalograms (EEGs) at critical sites of the epileptic brain, progressively converge (diverge) before (after) epileptic seizures, a phenomenon that has been called dynamical synchronization (desynchronization). This dynamical synchronization/desynchronization has already constituted the basis for the design and development of systems for long-term (tens of minutes), on-line, prospective prediction of epileptic seizures. Also, the criterion for the changes in the time constants of the observed synchronization/desynchronization at seizure points has been used to show resetting of the epileptic brain in patients with temporal lobe epilepsy (TLE), a phenomenon that implicates a possible homeostatic role for the seizures themselves to restore normal brain activity. In this paper, we introduce a new criterion to measure this resetting that utilizes changes in the level of observed synchronization/desynchronization. We compare this criterion's sensitivity of resetting with the old one based on the time constants of the observed synchronization/desynchronization. Next, we test the robustness of the resetting phenomena in terms of the utilized measures of EEG dynamics by a comparative study involving STL(max), a measure of phase (ϕ(max)) and a measure of energy (E) using both criteria (i.e. the level and time constants of the observed synchronization/desynchronization). The measures are estimated from intracranial electroencephalographic (iEEG) recordings with subdural and depth electrodes from two patients with focal temporal lobe epilepsy and a total of 43 seizures. Techniques from optimization theory, in particular quadratic bivalent programming, are applied to optimize the performance of the three measures in detecting preictal entrainment. It is

  4. Knowledge-intensive global optimization of Earth observing system architectures: a climate-centric case study

    NASA Astrophysics Data System (ADS)

    Selva, D.

    2014-10-01

    Requirements from the different disciplines of the Earth sciences on satellite missions have become considerably more stringent in the past decade, while budgets in space organizations have not increased to support the implementation of new systems meeting these requirements. At the same time, new technologies such as optical communications, electrical propulsion, nanosatellite technology, and new commercial agents and models such as hosted payloads are now available. The technical and programmatic environment is thus ideal to conduct architectural studies that look with renewed breadth and adequate depth to the myriad of new possible architectures for Earth Observing Systems. Such studies are challenging tasks, since they require formidable amounts of data and expert knowledge in order to be conducted. Indeed, trade-offs between hundreds or thousands of requirements from different disciplines need to be considered, and millions of combinations of instrument technologies and orbits are possible. This paper presents a framework and tool to support the exploration of such large architectural tradespaces. The framework can be seen as a model-based, executable science traceability matrix that can be used to compare the relative value of millions of different possible architectures. It is demonstrated with an operational climate-centric case study. Ultimately, this framework can be used to assess opportunities for international collaboration and look at architectures for a global Earth observing system, including space, air, and ground assets.

  5. Guiding automated NMR structure determination using a global optimization metric, the NMR DP score.

    PubMed

    Huang, Yuanpeng Janet; Mao, Binchen; Xu, Fei; Montelione, Gaetano T

    2015-08-01

    ASDP is an automated NMR NOE assignment program. It uses a distinct bottom-up topology-constrained network anchoring approach for NOE interpretation, with 2D, 3D and/or 4D NOESY peak lists and resonance assignments as input, and generates unambiguous NOE constraints for iterative structure calculations. ASDP is designed to function interactively with various structure determination programs that use distance restraints to generate molecular models. In the CASD-NMR project, ASDP was tested and further developed using blinded NMR data, including resonance assignments, either raw or manually-curated (refined) NOESY peak list data, and in some cases (15)N-(1)H residual dipolar coupling data. In these blinded tests, in which the reference structure was not available until after structures were generated, the fully-automated ASDP program performed very well on all targets using both the raw and refined NOESY peak list data. Improvements of ASDP relative to its predecessor program for automated NOESY peak assignments, AutoStructure, were driven by challenges provided by these CASD-NMR data. These algorithmic improvements include (1) using a global metric of structural accuracy, the discriminating power score, for guiding model selection during the iterative NOE interpretation process, and (2) identifying incorrect NOESY cross peak assignments caused by errors in the NMR resonance assignment list. These improvements provide a more robust automated NOESY analysis program, ASDP, with the unique capability of being utilized with alternative structure generation and refinement programs including CYANA, CNS, and/or Rosetta. PMID:26081575

  6. Optimal ?-Control for the Global Cauchy Problem of The Relativistic Vlasov-Poisson System

    NASA Astrophysics Data System (ADS)

    Young, Brent

    2011-12-01

    Recently, M.K.-H. Kiessling and A.S. Tahvildar-Zadeh proved that a unique global classical solution to the relativistic Vlasov-Poisson system exists whenever the positive, integrable initial datum is spherically symmetric, compactly supported in momentum space, vanishes on characteristics with vanishing angular momentum, and for β⩾3/2 has ?-norm strictly below a positive, critical value ?. Everything else being equal, data leading to finite time blow-up can be found with ?-norm surpassing ? for any β>1, with ? if and only if β⩾3/2. In their paper, the critical value for β=3/2 is calculated explicitly while the value for all other β is merely characterized as the infimum of a functional over an appropriate function space. In this work, the existence of minimizers is established, and the exact expression of ? is calculated in terms of the famous Lane-Emden functions. Numerical computations of the ? are presented along with some elementary asymptotics near the critical exponent 3/2.

  7. The q-G method : A q-version of the Steepest Descent method for global optimization.

    PubMed

    Soterroni, Aline C; Galski, Roberto L; Scarabello, Marluce C; Ramos, Fernando M

    2015-01-01

    In this work, the q-Gradient (q-G) method, a q-version of the Steepest Descent method, is presented. The main idea behind the q-G method is the use of the negative of the q-gradient vector of the objective function as the search direction. The q-gradient vector, or simply the q-gradient, is a generalization of the classical gradient vector based on the concept of Jackson's derivative from the q-calculus. Its use provides the algorithm an effective mechanism for escaping from local minima. The q-G method reduces to the Steepest Descent method when the parameter q tends to 1. The algorithm has three free parameters and it is implemented so that the search process gradually shifts from global exploration in the beginning to local exploitation in the end. We evaluated the q-G method on 34 test functions, and compared its performance with 34 optimization algorithms, including derivative-free algorithms and the Steepest Descent method. Our results show that the q-G method is competitive and has a great potential for solving multimodal optimization problems. PMID:26543781

  8. Optimizing Land and Water Use at the Local Level to Enhance Global Food Security through Virtual Resources Trade in the World

    NASA Astrophysics Data System (ADS)

    Cai, X.; Zhang, X.; Zhu, T.

    2014-12-01

    Global food security is constrained by local and regional land and water availability, as well as other agricultural input limitations and inappropriate national and global regulations. In a theoretical context, this study assumes that optimal water and land uses in local food production to maximize food security and social welfare at the global level can be driven by global trade. It follows the context of "virtual resources trade", i.e., utilizing international trade of agricultural commodities to reduce dependency on local resources, and achieves land and water savings in the world. An optimization model based on the partial equilibrium of agriculture is developed for the analysis, including local commodity production and land and water resources constraints, demand by country, and global food market. Through the model, the marginal values (MVs) of social welfare for water and land at the level of so-called food production units (i.e., sub-basins with similar agricultural production conditions) are derived and mapped in the world. In this personation, we will introduce the model structure, explain the meaning of MVs at the local level and their distribution around the world, and discuss the policy implications for global communities to enhance global food security. In particular, we will examine the economic values of water and land under different world targets of food security (e.g., number of malnourished population or children in a future year). In addition, we will also discuss the opportunities on data to improve such global modeling exercises.

  9. Robust breathing signal extraction from cone beam CT projections based on adaptive and global optimization techniques.

    PubMed

    Chao, Ming; Wei, Jie; Li, Tianfang; Yuan, Yading; Rosenzweig, Kenneth E; Lo, Yeh-Chi

    2016-04-21

    We present a study of extracting respiratory signals from cone beam computed tomography (CBCT) projections within the framework of the Amsterdam Shroud (AS) technique. Acquired prior to the radiotherapy treatment, CBCT projections were preprocessed for contrast enhancement by converting the original intensity images to attenuation images with which the AS image was created. An adaptive robust z-normalization filtering was applied to further augment the weak oscillating structures locally. From the enhanced AS image, the respiratory signal was extracted using a two-step optimization approach to effectively reveal the large-scale regularity of the breathing signals. CBCT projection images from five patients acquired with the Varian Onboard Imager on the Clinac iX System Linear Accelerator (Varian Medical Systems, Palo Alto, CA) were employed to assess the proposed technique. Stable breathing signals can be reliably extracted using the proposed algorithm. Reference waveforms obtained using an air bellows belt (Philips Medical Systems, Cleveland, OH) were exported and compared to those with the AS based signals. The average errors for the enrolled patients between the estimated breath per minute (bpm) and the reference waveform bpm can be as low as -0.07 with the standard deviation 1.58. The new algorithm outperformed the original AS technique for all patients by 8.5% to 30%. The impact of gantry rotation on the breathing signal was assessed with data acquired with a Quasar phantom (Modus Medical Devices Inc., London, Canada) and found to be minimal on the signal frequency. The new technique developed in this work will provide a practical solution to rendering markerless breathing signal using the CBCT projections for thoracic and abdominal patients. PMID:27008349

  10. Robust breathing signal extraction from cone beam CT projections based on adaptive and global optimization techniques

    NASA Astrophysics Data System (ADS)

    Chao, Ming; Wei, Jie; Li, Tianfang; Yuan, Yading; Rosenzweig, Kenneth E.; Lo, Yeh-Chi

    2016-04-01

    We present a study of extracting respiratory signals from cone beam computed tomography (CBCT) projections within the framework of the Amsterdam Shroud (AS) technique. Acquired prior to the radiotherapy treatment, CBCT projections were preprocessed for contrast enhancement by converting the original intensity images to attenuation images with which the AS image was created. An adaptive robust z-normalization filtering was applied to further augment the weak oscillating structures locally. From the enhanced AS image, the respiratory signal was extracted using a two-step optimization approach to effectively reveal the large-scale regularity of the breathing signals. CBCT projection images from five patients acquired with the Varian Onboard Imager on the Clinac iX System Linear Accelerator (Varian Medical Systems, Palo Alto, CA) were employed to assess the proposed technique. Stable breathing signals can be reliably extracted using the proposed algorithm. Reference waveforms obtained using an air bellows belt (Philips Medical Systems, Cleveland, OH) were exported and compared to those with the AS based signals. The average errors for the enrolled patients between the estimated breath per minute (bpm) and the reference waveform bpm can be as low as  -0.07 with the standard deviation 1.58. The new algorithm outperformed the original AS technique for all patients by 8.5% to 30%. The impact of gantry rotation on the breathing signal was assessed with data acquired with a Quasar phantom (Modus Medical Devices Inc., London, Canada) and found to be minimal on the signal frequency. The new technique developed in this work will provide a practical solution to rendering markerless breathing signal using the CBCT projections for thoracic and abdominal patients.

  11. The Mars Global Subsurface Sounder: A Mission Optimized for the Volatile and Geologic Characterization of the Martian Subsurface

    NASA Astrophysics Data System (ADS)

    Clifford, S. M.; Delemere, W.; Gogineni, P. S.

    2011-12-01

    The MARSIS and SHARAD orbital radar sounders have given tantalizing glimpses of subsurface fof Mars. But, to be accommodated aboard spacecraft with a number of other high-level investigations, MARSIS and SHARAD had to accept some compromises in instrument design and operation that have limited their potential capabilities. Here we describe a proposal for a new Mars orbital radar mission, the Mars Global Subsurface Sounder (MGSS), that is solely dedicated to sub-surface sounding, allowing it to achieve maximum spatial resolution and penetration depth through an optimized orbit, antenna design, increased power and significantly improved signal to noise ratio. The chief science goals of this mission are to investigate the stratigraphic and structural evolution of the Martian subsurface and polar layered deposits (PLD), as well as the distribution and state of subsurface water (whether as a liquid or as massive ice deposits) through the acquisition of a 3-D radar map to depths ranging from 1 km, in lithic environments, and up to 4 km in the PLD. The MARSIS and SHARAD radar investigations have provided clear demonstrations of the capabilities of deep-sounding radar to conduct similar investigations. The MGSS is expected to significantly improve on this performance by taking advantage a spacecraft and mission optimized for radar sounding. Over its 2-year mission duration, the MGSS will be able to compile a global 3-D map of local variations in dielectric properties, with a horizontal resolution of ~1 km and vertical resolution of ~10-20 m MGSS is a dual-band radar sounder that operates at 1-6 MHz and 15-25 MHz. 2-D SAR processing is used to maximize both along and cross track resolution and clutter suppression, while onboard along track processing minimizes the downlink data rate. The spacecraft has sufficient mass margin to incorporate sufficient shielding minimize signal degradation by electromagnetic interference and maximize the signal to noise ratio. The orbit of

  12. MODELING VERY LONG BASELINE INTERFEROMETRIC IMAGES WITH THE CROSS-ENTROPY GLOBAL OPTIMIZATION TECHNIQUE

    SciTech Connect

    Caproni, A.; Toffoli, R. T.; Monteiro, H.; Abraham, Z.; Teixeira, D. M.

    2011-07-20

    We present a new technique for obtaining model fittings to very long baseline interferometric images of astrophysical jets. The method minimizes a performance function proportional to the sum of the squared difference between the model and observed images. The model image is constructed by summing N{sub s} elliptical Gaussian sources characterized by six parameters: two-dimensional peak position, peak intensity, eccentricity, amplitude, and orientation angle of the major axis. We present results for the fitting of two main benchmark jets: the first constructed from three individual Gaussian sources, the second formed by five Gaussian sources. Both jets were analyzed by our cross-entropy technique in finite and infinite signal-to-noise regimes, the background noise chosen to mimic that found in interferometric radio maps. Those images were constructed to simulate most of the conditions encountered in interferometric images of active galactic nuclei. We show that the cross-entropy technique is capable of recovering the parameters of the sources with a similar accuracy to that obtained from the very traditional Astronomical Image Processing System Package task IMFIT when the image is relatively simple (e.g., few components). For more complex interferometric maps, our method displays superior performance in recovering the parameters of the jet components. Our methodology is also able to show quantitatively the number of individual components present in an image. An additional application of the cross-entropy technique to a real image of a BL Lac object is shown and discussed. Our results indicate that our cross-entropy model-fitting technique must be used in situations involving the analysis of complex emission regions having more than three sources, even though it is substantially slower than current model-fitting tasks (at least 10,000 times slower for a single processor, depending on the number of sources to be optimized). As in the case of any model fitting

  13. Conference on "Multidisciplinary approaches to nutritional problems". Rank Prize Lecture. Global nutrition challenges for optimal health and well-being.

    PubMed

    Uauy, Ricardo; Corvalan, Camila; Dangour, Alan D

    2009-02-01

    Optimal health and well-being are now considered the true measures of human development. Integrated strategies for infant, child and adult nutrition are required that take a life-course perspective to achieve life-long health. The major nutrition challenges faced today include: (a) addressing the pending burden of undernutrition (low birth weight, severe wasting, stunting and Zn, retinol, Fe, iodine and folic acid deficits) affecting those individuals living in conditions of poverty and deprivation; (b) preventing nutrition-related chronic diseases (obesity, diabetes, CVD, some forms of cancer and osteoporosis) that, except in sub-Saharan Africa, are the main causes of death and disability globally. This challenge requires a life-course perspective as effective prevention starts before conception and continues at each stage of life. While death is unavoidable, premature death and disability can be postponed by providing the right amount and quality of food and by maintaining an active life; (c) delaying or avoiding, via appropriate nutrition and physical activity interventions, the functional declines associated with advancing age. To help tackle these challenges, it is proposed that the term 'malnutrition in all its forms', which encompasses the full spectrum of nutritional disorders, should be used to engender a broader understanding of global nutrition problems. This term may prove particularly helpful when interacting with policy makers and the public. Finally, a greater effort by the UN agencies and private and public development partners is called for to strengthen local, regional and international capacity to support the much needed change in policy and programme activities focusing on all forms of malnutrition with a unified agenda. PMID:19012808

  14. Global 3-D FDTD Maxwell's-Equations Modeling of Ionospheric Disturbances Associated with Earthquakes Using an Optimized Geodesic Grid

    NASA Astrophysics Data System (ADS)

    Simpson, J. J.; Taflove, A.

    2005-12-01

    We report a finite-difference time-domain (FDTD) computational solution of Maxwell's equations [1] that models the possibility of detecting and characterizing ionospheric disturbances above seismic regions. Specifically, we study anomalies in Schumann resonance spectra in the extremely low frequency (ELF) range below 30 Hz as observed in Japan caused by a hypothetical cylindrical ionospheric disturbance above Taiwan. We consider excitation of the global Earth-ionosphere waveguide by lightning in three major thunderstorm regions of the world: Southeast Asia, South America (Amazon region), and Africa. Furthermore, we investigate varying geometries and characteristics of the ionospheric disturbance above Taiwan. The FDTD technique used in this study enables a direct, full-vector, three-dimensional (3-D) time-domain Maxwell's equations calculation of round-the-world ELF propagation accounting for arbitrary horizontal as well as vertical geometrical and electrical inhomogeneities and anisotropies of the excitation, ionosphere, lithosphere, and oceans. Our entire-Earth model grids the annular lithosphere-atmosphere volume within 100 km of sea level, and contains over 6,500,000 grid-points (63 km laterally between adjacent grid points, 5 km radial resolution). We use our recently developed spherical geodesic gridding technique having a spatial discretization best described as resembling the surface of a soccer ball [2]. The grid is comprised entirely of hexagonal cells except for a small fixed number of pentagonal cells needed for completion. Grid-cell areas and locations are optimized to yield a smoothly varying area difference between adjacent cells, thereby maximizing numerical convergence. We compare our calculated results with measured data prior to the Chi-Chi earthquake in Taiwan as reported by Hayakawa et. al. [3]. Acknowledgement This work was suggested by Dr. Masashi Hayakawa, University of Electro-Communications, Chofugaoka, Chofu Tokyo. References [1] A

  15. Global optimization of a deuterium calibrated, discrete-state compartment model (DSCM): Application to the eastern Nevada Test Site

    NASA Astrophysics Data System (ADS)

    Carroll, Rosemary W. H.; Pohll, Greg M.; Earman, Sam; Hershey, Ronald L.

    2007-10-01

    SummaryAs part of a larger study to estimate groundwater recharge volumes in the area of the eastern Nevada Test Site (NTS), [Campana, M.E., 1975. Finite-state models of transport phenomena in hydrologic systems, PhD Dissertation: University of Arizona, Tucson] Discrete-state compartment model (DSCM) was re-coded to simulate steady-state groundwater concentrations of a conservative tracer. It was then dynamically linked with the shuffled complex evolution (SCE) optimization algorithm [Duan, Q., Soroosh, S., Gupta, V., 1992. Effective and efficient global optimization for conceptual rainfall-runoff models. Water Resources Research 28(4), 1015-1031] in which both flow direction and magnitude were adjusted to minimize errors in predicted tracer concentrations. Code validation on a simple four-celled model showed the algorithm consistent in model predictions and capable of reproducing expected cell outflows with relatively little error. The DSCM-SCE code was then applied to a 15-basin (cell) eastern NTS model developed for the DSCM. Auto-calibration of the NTS model was run given two modeling scenarios, (a) assuming known groundwater flow directions and solving only for magnitudes and, (b) solving for groundwater flow directions and magnitudes. The SCE is a fairly robust algorithm, unlike simulated annealing or modified Gauss-Newton approaches. The DSCM-SCE improves upon its original counterpart by being more user-friendly and by auto-calibrating complex models in minutes to hours. While the DSCM-SCE can provide numerical support to a working hypothesis, it can not definitively define a flow system based solely on δD values given few hydrogeologic constraints on boundary conditions and cell-to-cell interactions.

  16. Global optimization and oxygen dissociation on polyicosahedral Ag32Cu6 core-shell cluster for alkaline fuel cells

    NASA Astrophysics Data System (ADS)

    Zhang, N.; Chen, F. Y.; Wu, X. Q.

    2015-07-01

    The structure of 38 atoms Ag-Cu cluster is studied by using a combination of a genetic algorithm global optimization technique and density functional theory (DFT) calculations. It is demonstrated that the truncated octahedral (TO) Ag32Cu6 core-shell cluster is less stable than the polyicosahedral (pIh) Ag32Cu6 core-shell cluster from the atomistic models and the DFT calculation shows an agreeable result, so the newfound pIh Ag32Cu6 core-shell cluster is further investigated for potential application for O2 dissociation in oxygen reduction reaction (ORR). The activation energy barrier for the O2 dissociation on pIh Ag32Cu6 core-shell cluster is 0.715 eV, where the d-band center is -3.395 eV and the density of states at the Fermi energy level is maximal for the favorable absorption site, indicating that the catalytic activity is attributed to a maximal charge transfer between an oxygen molecule and the pIh Ag32Cu6 core-shell cluster. This work revises the earlier idea that Ag32Cu6 core-shell nanoparticles are not suitable as ORR catalysts and confirms that Ag-Cu nanoalloy is a potential candidate to substitute noble Pt-based catalyst in alkaline fuel cells.

  17. Global optimization and oxygen dissociation on polyicosahedral Ag32Cu6 core-shell cluster for alkaline fuel cells

    PubMed Central

    Zhang, N.; Chen, F. Y.; Wu, X.Q.

    2015-01-01

    The structure of 38 atoms Ag-Cu cluster is studied by using a combination of a genetic algorithm global optimization technique and density functional theory (DFT) calculations. It is demonstrated that the truncated octahedral (TO) Ag32Cu6 core-shell cluster is less stable than the polyicosahedral (pIh) Ag32Cu6 core-shell cluster from the atomistic models and the DFT calculation shows an agreeable result, so the newfound pIh Ag32Cu6 core-shell cluster is further investigated for potential application for O2 dissociation in oxygen reduction reaction (ORR). The activation energy barrier for the O2 dissociation on pIh Ag32Cu6 core-shell cluster is 0.715 eV, where the d-band center is −3.395 eV and the density of states at the Fermi energy level is maximal for the favorable absorption site, indicating that the catalytic activity is attributed to a maximal charge transfer between an oxygen molecule and the pIh Ag32Cu6 core-shell cluster. This work revises the earlier idea that Ag32Cu6 core-shell nanoparticles are not suitable as ORR catalysts and confirms that Ag-Cu nanoalloy is a potential candidate to substitute noble Pt-based catalyst in alkaline fuel cells. PMID:26148904

  18. Global alignment optimization strategies, procedures, and tools for the James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM)

    NASA Astrophysics Data System (ADS)

    Bos, Brent J.; Howard, Joseph M.; Young, Philip J.; Gracey, Renee; Seals, Lenward T.; Ohl, Raymond G.

    2012-09-01

    During cryogenic vacuum testing of the James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM), the global alignment of the ISIM with respect to the designed interface of the JWST optical telescope element (OTE) will be measured through a series of optical characterization tests. These tests will determine the locations and orientations of the JWST science instrument projected focal surfaces and entrance pupils with respect to their corresponding OTE optical interfaces. Thermal, finite element and optical modeling will then be used to predict the on-orbit optical performance of the observatory. If any optical performance non-compliances are identified, the ISIM will be adjusted to improve its performance. If this becomes necessary, ISIM has a variety of adjustments that can be made. The lengths of the six kinematic mount struts that attach the ISIM to the OTE can be modified and five science instrument focus positions and two pupil positions can be individually adjusted as well. In order to understand how to manipulate the ISIM’s degrees of freedom properly and to prepare for the ISIM flight model testing, we have completed a series of optical-mechanical analyses to develop and identify the best approaches for bringing a non-compliant ISIM Element back into compliance. During this work several unknown misalignment scenarios were produced and the simulated optical performance metrics were input into various mathematical modeling and optimization tools to determine how the ISIM degrees of freedom should be adjusted to provide the best overall optical performance.

  19. Global optimization study of small (10 < or = N < or = 120) Pd clusters supported on MgO(100).

    PubMed

    Rossi, G; Mottet, C; Nita, F; Ferrando, R

    2006-04-13

    Experimental evidence suggests that Pd clusters on MgO, known to be good reaction catalysts, have face centered cubic (fcc) epitaxial structures. The structure of such clusters is the result of the interplay of Pd-Pd and Pd-substrate bonds, the former inclined to favor icosahedral (Ih) and decahedral (Dh)-like structures, the latter leading to place Pd atoms on top of oxygen sites, according to an epitaxial stacking. This paper shows the results of a basin-hopping global optimization procedure applied to free and MgO-supported Pd clusters in the size range 10 < or = N < or = 120. Pd-MgO interactions are modeled by an analytical function fitted to ab initio results, while Pd-Pd interactions are modeled by a semiempirical potential. Besides the tight-binding Rosato-Guillopé-Legrand (RGL) potential, we have adopted a modified version of RGL that better reproduces the experimental surface energy of palladium, modifying the attractive part of Pd atoms potential energy. We have compared the two potential models, and as a result, the RGL potential favors clusters with epitaxial arrangements, so that cluster structures are epitaxial fcc in almost all the size ranges considered. On the contrary, the alternative potential model preserves some Ih-like characteristics typical of the free Pd clusters, and it suggests that a transition size from Ih-like to epitaxial structures can take place at about 100 atoms. PMID:16599522

  20. Age-associated differences in global and segmental control during dual-task walking under sub-optimal sensory conditions.

    PubMed

    Deshpande, Nandini; Hewston, Patricia; Yoshikawa, Mika

    2015-04-01

    The ability to safely perform cognitive-motor dual-tasks is critical for independence of older adults. We compared age-associated differences in global and segmental control during dual-task walking in sub-optimal sensory conditions. Thirteen young (YA) and 13 healthy older (OA) adults walked a straight pathway with cognitive dual-task of walking-while-talking (WT) or no-WT under four sensory conditions. On randomly selected trials, visual and vestibular inputs were manipulated using blurring goggles (BV) and Galvanic Vestibular Stimulation (GVS), respectively. Gait speed decreased more in YA than OA during WT. Gait speed increased with GVS with normal vision but not BV. Step length considerably decreased with WT. Trunk roll significantly decreased only in OA with GVS in WT. Head roll significantly decreased with GVS regardless of age. Results indicate GVS-induced adaptations were dependent on available visual information. YA reduced their gait speed more than OA to achieve a similar pace to safely perform WT. GVS resulted in both age-groups to reduce head movement. However, with the addition of WT during GVS, OA also stiffened their trunk. Therefore, with increased attentional demands healthy OA employed different compensatory strategies than YA to maintain postural control. PMID:25617991

  1. Framework for Optimal Global Vaccine Stockpile Design for Vaccine-Preventable Diseases: Application to Measles and Cholera Vaccines as Contrasting Examples.

    PubMed

    Thompson, Kimberly M; Duintjer Tebbens, Radboud J

    2016-07-01

    Managing the dynamics of vaccine supply and demand represents a significant challenge with very high stakes. Insufficient vaccine supplies can necessitate rationing, lead to preventable adverse health outcomes, delay the achievements of elimination or eradication goals, and/or pose reputation risks for public health authorities and/or manufacturers. This article explores the dynamics of global vaccine supply and demand to consider the opportunities to develop and maintain optimal global vaccine stockpiles for universal vaccines, characterized by large global demand (for which we use measles vaccines as an example), and nonuniversal (including new and niche) vaccines (for which we use oral cholera vaccine as an example). We contrast our approach with other vaccine stockpile optimization frameworks previously developed for the United States pediatric vaccine stockpile to address disruptions in supply and global emergency response vaccine stockpiles to provide on-demand vaccines for use in outbreaks. For measles vaccine, we explore the complexity that arises due to different formulations and presentations of vaccines, consideration of rubella, and the context of regional elimination goals. We conclude that global health policy leaders and stakeholders should procure and maintain appropriate global vaccine rotating stocks for measles and rubella vaccine now to support current regional elimination goals, and should probably also do so for other vaccines to help prevent and control endemic or epidemic diseases. This work suggests the need to better model global vaccine supplies to improve efficiency in the vaccine supply chain, ensure adequate supplies to support elimination and eradication initiatives, and support progress toward the goals of the Global Vaccine Action Plan. PMID:25109229

  2. Transport of bromide and pesticides through an undisturbed soil column: a modeling study with global optimization analysis.

    PubMed

    Dusek, Jaromir; Dohnal, Michal; Snehota, Michal; Sobotkova, Martina; Ray, Chittaranjan; Vogel, Tomas

    2015-01-01

    The fate of pesticides in tropical soils is still not understood as well as it is for soils in temperate regions. In this study, water flow and transport of bromide tracer and five pesticides (atrazine, imazaquin, sulfometuron methyl, S-metolachlor, and imidacloprid) through an undisturbed soil column of tropical Oxisol were analyzed using a one-dimensional numerical model. The numerical model is based on Richards' equation for solving water flow, and the advection-dispersion equation for solving solute transport. Data from a laboratory column leaching experiment were used in the uncertainty analysis using a global optimization methodology to evaluate the model's sensitivity to transport parameters. All pesticides were found to be relatively mobile (sorption distribution coefficients lower than 2 cm(3) g(-1)). Experimental data indicated significant non-conservative behavior of bromide tracer. All pesticides, with the exception of imidacloprid, were found less persistent (degradation half-lives smaller than 45 days). Three of the five pesticides (atrazine, sulfometuron methyl, and S-metolachlor) were better described by the linear kinetic sorption model, while the breakthrough curves of imazaquin and imidacloprid were more appropriately approximated using nonlinear instantaneous sorption. Sensitivity analysis suggested that the model is most sensitive to sorption distribution coefficient. The prediction limits contained most of the measured points of the experimental breakthrough curves, indicating adequate model concept and model structure for the description of transport processes in the soil column under study. Uncertainty analysis using a physically-based Monte Carlo modeling of pesticide fate and transport provides useful information for the evaluation of chemical leaching in Hawaii soils. PMID:25703186

  3. Transport of bromide and pesticides through an undisturbed soil column: A modeling study with global optimization analysis

    NASA Astrophysics Data System (ADS)

    Dusek, Jaromir; Dohnal, Michal; Snehota, Michal; Sobotkova, Martina; Ray, Chittaranjan; Vogel, Tomas

    2015-04-01

    The fate of pesticides in tropical soils is still not understood as well as it is for soils in temperate regions. In this study, water flow and transport of bromide tracer and five pesticides (atrazine, imazaquin, sulfometuron methyl, S-metolachlor, and imidacloprid) through an undisturbed soil column of tropical Oxisol were analyzed using a one-dimensional numerical model. The numerical model is based on Richards' equation for solving water flow, and the advection-dispersion equation for solving solute transport. Data from a laboratory column leaching experiment were used in the uncertainty analysis using a global optimization methodology to evaluate the model's sensitivity to transport parameters. All pesticides were found to be relatively mobile (sorption distribution coefficients lower than 2 cm3 g- 1). Experimental data indicated significant non-conservative behavior of bromide tracer. All pesticides, with the exception of imidacloprid, were found less persistent (degradation half-lives smaller than 45 days). Three of the five pesticides (atrazine, sulfometuron methyl, and S-metolachlor) were better described by the linear kinetic sorption model, while the breakthrough curves of imazaquin and imidacloprid were more appropriately approximated using nonlinear instantaneous sorption. Sensitivity analysis suggested that the model is most sensitive to sorption distribution coefficient. The prediction limits contained most of the measured points of the experimental breakthrough curves, indicating adequate model concept and model structure for the description of transport processes in the soil column under study. Uncertainty analysis using a physically-based Monte Carlo modeling of pesticide fate and transport provides useful information for the evaluation of chemical leaching in Hawaii soils.

  4. Developing an optimally estimated earth gravity model to degree and order 360 from a global set of 30 deg x 30 deg mean surface gravity anomalies

    NASA Astrophysics Data System (ADS)

    Gleason, D. M.

    An optimally estimated earth gravity model (EGM), consisting of a set of geopotential coefficients through a maximum degree and order of 360, has been created from a global set of 259,200 30 deg by 30 deg surface mean gravity anomalies. The model is optimal in the sense that its derivation follows the principles of least-squares collocation which results in the coefficients' error variance/covariance matrix having a minimal trace value. This paper presents: (1) an overview of the mathematical and geodetic principles behind the construction of the model, (2) a discussion on the practical concerns and problems associated with the implementation of these principles on a present-day high speed computer, (3) a brief description of the global 30 deg input mean anomaly file used, (4) an analysis of the statistical properties of the coefficients and their accuracies, and (5) a prognosis for the future.

  5. Definition of a 'guiding function' in global optimization: a hybrid approach combining energy and R-factor in structure solution from powder diffraction data

    NASA Astrophysics Data System (ADS)

    Lanning, Oliver J.; Habershon, Scott; Harris, Kenneth D. M.; Johnston, Roy L.; Kariuki, Benson M.; Tedesco, Emilio; Turner, Giles W.

    2000-02-01

    Two global optimization problems of current interest in solid state sciences are crystal structure prediction (optimization of structure with respect to computed energy) and direct-space techniques for crystal structure solution from powder diffraction data (optimization of structure with respect to R-factor). As the energy and R-factor hypersurfaces are based on the same parameter space but have differing characteristics, there is a direct opportunity to blend these approaches together in the definition of a hybrid hypersurface. A strategy for combining R-factor and energy within a direct-space method for structure solution from powder diffraction data is proposed. Normalized energy and normalized R-factor functions are defined, and are combined using a sliding weighting function to give a hybrid figure-of-merit G, which behaves as energy when energy is high (thus using energy to guide the calculation towards energetically plausible structures) and gives increasing importance to R-factor as lower energies are approached. This concept of a `guiding function' may be widely applicable in other global optimization problems.

  6. Global parameter optimization of a Mather-type plasma focus in the framework of the Gratton-Vargas two-dimensional snowplow model

    NASA Astrophysics Data System (ADS)

    Auluck, S. K. H.

    2014-12-01

    Dense plasma focus (DPF) is known to produce highly energetic ions, electrons and plasma environment which can be used for breeding short-lived isotopes, plasma nanotechnology and other material processing applications. Commercial utilization of DPF in such areas would need a design tool that can be deployed in an automatic search for the best possible device configuration for a given application. The recently revisited (Auluck 2013 Phys. Plasmas 20 112501) Gratton-Vargas (GV) two-dimensional analytical snowplow model of plasma focus provides a numerical formula for dynamic inductance of a Mather-type plasma focus fitted to thousands of automated computations, which enables the construction of such a design tool. This inductance formula is utilized in the present work to explore global optimization, based on first-principles optimality criteria, in a four-dimensional parameter-subspace of the zero-resistance GV model. The optimization process is shown to reproduce the empirically observed constancy of the drive parameter over eight decades in capacitor bank energy. The optimized geometry of plasma focus normalized to the anode radius is shown to be independent of voltage, while the optimized anode radius is shown to be related to capacitor bank inductance.

  7. Desirability-based multiobjective optimization for global QSAR studies: application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles.

    PubMed

    Cruz-Monteagudo, Maykel; Borges, Fernanda; Cordeiro, M Natália D S

    2008-11-15

    Up to now, very few reports have been published concerning the application of multiobjective optimization (MOOP) techniques to quantitative structure-activity relationship (QSAR) studies. However, none reports the optimization of objectives related directly to the desired pharmaceutical profile of the drug. In this work, for the first time, it is proposed a MOOP method based on Derringer's desirability function that allows conducting global QSAR studies considering simultaneously the pharmacological, pharmacokinetic and toxicological profile of a set of molecule candidates. The usefulness of the method is demonstrated by applying it to the simultaneous optimization of the analgesic, antiinflammatory, and ulcerogenic properties of a library of fifteen 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-one compounds. The levels of the predictor variables producing concurrently the best possible compromise between these properties is found and used to design a set of new optimized drug candidates. Our results also suggest the relevant role of the bulkiness of alkyl substituents on the C-2 position of the quinazoline ring over the ulcerogenic properties for this family of compounds. Finally, and most importantly, the desirability-based MOOP method proposed is a valuable tool and shall aid in the future rational design of novel successful drugs. PMID:18452123

  8. Assured Optimism in a Scottish Girls' School: Habitus and the (Re)production of Global Privilege

    ERIC Educational Resources Information Center

    Forbes, Joan; Lingard, Bob

    2015-01-01

    This paper examines how high levels of social-cultural connectedness and academic excellence, inflected by gender and social class, constitute a particular school habitus of "assured optimism" at an elite Scottish girls' school. In Bourdieuian terms, Dalrymple is a "forcing ground" for the "intense cultivation"…

  9. Computing global minimizers to a constrained B-spline image registration problem from optimal l1 perturbations to block match data

    PubMed Central

    Castillo, Edward; Castillo, Richard; Fuentes, David; Guerrero, Thomas

    2014-01-01

    Purpose: Block matching is a well-known strategy for estimating corresponding voxel locations between a pair of images according to an image similarity metric. Though robust to issues such as image noise and large magnitude voxel displacements, the estimated point matches are not guaranteed to be spatially accurate. However, the underlying optimization problem solved by the block matching procedure is similar in structure to the class of optimization problem associated with B-spline based registration methods. By exploiting this relationship, the authors derive a numerical method for computing a global minimizer to a constrained B-spline registration problem that incorporates the robustness of block matching with the global smoothness properties inherent to B-spline parameterization. Methods: The method reformulates the traditional B-spline registration problem as a basis pursuit problem describing the minimal l1-perturbation to block match pairs required to produce a B-spline fitting error within a given tolerance. The sparsity pattern of the optimal perturbation then defines a voxel point cloud subset on which the B-spline fit is a global minimizer to a constrained variant of the B-spline registration problem. As opposed to traditional B-spline algorithms, the optimization step involving the actual image data is addressed by block matching. Results: The performance of the method is measured in terms of spatial accuracy using ten inhale/exhale thoracic CT image pairs (available for download at www.dir-lab.com) obtained from the COPDgene dataset and corresponding sets of expert-determined landmark point pairs. The results of the validation procedure demonstrate that the method can achieve a high spatial accuracy on a significantly complex image set. Conclusions: The proposed methodology is demonstrated to achieve a high spatial accuracy and is generalizable in that in can employ any displacement field parameterization described as a least squares fit to block match

  10. Enhancing artificial bee colony algorithm with self-adaptive searching strategy and artificial immune network operators for global optimization.

    PubMed

    Chen, Tinggui; Xiao, Renbin

    2014-01-01

    Artificial bee colony (ABC) algorithm, inspired by the intelligent foraging behavior of honey bees, was proposed by Karaboga. It has been shown to be superior to some conventional intelligent algorithms such as genetic algorithm (GA), artificial colony optimization (ACO), and particle swarm optimization (PSO). However, the ABC still has some limitations. For example, ABC can easily get trapped in the local optimum when handing in functions that have a narrow curving valley, a high eccentric ellipse, or complex multimodal functions. As a result, we proposed an enhanced ABC algorithm called EABC by introducing self-adaptive searching strategy and artificial immune network operators to improve the exploitation and exploration. The simulation results tested on a suite of unimodal or multimodal benchmark functions illustrate that the EABC algorithm outperforms ACO, PSO, and the basic ABC in most of the experiments. PMID:24772023

  11. Enhancing Artificial Bee Colony Algorithm with Self-Adaptive Searching Strategy and Artificial Immune Network Operators for Global Optimization

    PubMed Central

    Chen, Tinggui; Xiao, Renbin

    2014-01-01

    Artificial bee colony (ABC) algorithm, inspired by the intelligent foraging behavior of honey bees, was proposed by Karaboga. It has been shown to be superior to some conventional intelligent algorithms such as genetic algorithm (GA), artificial colony optimization (ACO), and particle swarm optimization (PSO). However, the ABC still has some limitations. For example, ABC can easily get trapped in the local optimum when handing in functions that have a narrow curving valley, a high eccentric ellipse, or complex multimodal functions. As a result, we proposed an enhanced ABC algorithm called EABC by introducing self-adaptive searching strategy and artificial immune network operators to improve the exploitation and exploration. The simulation results tested on a suite of unimodal or multimodal benchmark functions illustrate that the EABC algorithm outperforms ACO, PSO, and the basic ABC in most of the experiments. PMID:24772023

  12. Changes in Soybean Global Gene Expression after Application of Lipo-Chitooligosaccharide from Bradyrhizobium japonicum under Sub-Optimal Temperature

    PubMed Central

    Wang, Nan; Khan, Wajahatullah; Smith, Donald L.

    2012-01-01

    Lipo-chitooligosaccharides (LCOs), signal compounds produced by N2-fixing rhizobacteria after isoflavone induction, initiate nodule formation in host legumes. Given LCOs' structural similarity to pathogen-response-eliciting chitin oligomers, foliar application of LCOs was tested for ability to induce stress-related genes under optimal growth conditions. In order to study the effects of LCO foliar spray under stressed conditions, soybean (Glycine max) seedlings grown at optimal temperature were transferred to sub-optimal temperature. After a 5-day acclimation period, the first trifoliate leaves were sprayed with 10−7 M LCO (NodBj-V (C18∶1, MeFuc)) purified from genistein-induced Bradyrhizobium japonicum culture, and harvested at 0 and 48 h following treatment. Microarray analysis was performed using Affymetrix GeneChip® Soybean Genome Arrays. Compared to the control at 48 h after LCO treatment, a total of 147 genes were differentially expressed as a result of LCO treatment, including a number of stress-related genes and transcription factors. In addition, during the 48 h time period following foliar spray application, over a thousand genes exhibited differential expression, including hundreds of those specific to the LCO-treated plants. Our results indicated that the dynamic soybean foliar transcriptome was highly responsive to LCO treatment. Quantitative real-time PCR (qPCR) validated the microarray data. PMID:22348109

  13. Optimization of the design of a crucible for a SiC sublimation growth system using a global model

    NASA Astrophysics Data System (ADS)

    Chen, X. J.; Liu, L. J.; Tezuka, H.; Usuki, Y.; Kakimoto, K.

    2008-04-01

    Induction heating, temperature field and growth rate for a sublimation growth system of silicon carbide were calculated by using a global simulation model. The effects of shape of the crucible on temperature distribution and growth rate were investigated. It was found that thickness of the substrate holder, distance between the powder and substrate, and angle between the crucible wall and powder free surface are important for growth rate and crystal quality. Finally, a curved powder free surface was also studied. The results indicate that the use of a curved powder free surface is also an effective method for obtaining a higher growth rate.

  14. Continuity-based model interfacing for plant-wide simulation: a general approach.

    PubMed

    Volcke, Eveline I P; van Loosdrecht, Mark C M; Vanrolleghem, Peter A

    2006-08-01

    In plant-wide simulation studies of wastewater treatment facilities, often existing models from different origin need to be coupled. However, as these submodels are likely to contain different state variables, their coupling is not straightforward. The continuity-based interfacing method (CBIM) provides a general framework to construct model interfaces for models of wastewater systems, taking into account conservation principles. In this contribution, the CBIM approach is applied to study the effect of sludge digestion reject water treatment with a SHARON-Anammox process on a plant-wide scale. Separate models were available for the SHARON process and for the Anammox process. The Benchmark simulation model no. 2 (BSM2) is used to simulate the behaviour of the complete WWTP including sludge digestion. The CBIM approach is followed to develop three different model interfaces. At the same time, the generally applicable CBIM approach was further refined and particular issues when coupling models in which pH is considered as a state variable, are pointed out. PMID:16846629

  15. I37NO: an IMS infrasound array in northern Norway for optimal monitoring of infrasound on global and regional scales

    NASA Astrophysics Data System (ADS)

    Kvaerna, Tormod; Gibbons, Steven; Fyen, Jan; Roth, Michael

    2014-05-01

    The IMS infrasound array I37NO near Bardufoss in northern Norway became operational in October 2013 and was certified on December 19, 2013. The 10-element array has an aperture of approximately 1.5 km and is deployed in low-lying woodland about 2.5 degrees north of the Arctic Circle. Its location in the European Arctic means that the array fills an important gap in the global IMS infrasound monitoring network. In addition, I37NO extends significantly the network of infrasound stations in northern Norway, Sweden, Finland, and Russia: operated by NORSAR, the Swedish Institute for Space Physics, and the Kola Regional Seismological Center in Apatity. The geometry is based on the highly successful classical design for regional seismic arrays with sensors arranged in two approximately concentric rings surrounding a central site. A 4-site subarray with an aperture of approximately 450 meters, comprising the central element and the inner ring of 3 sites, provides an excellent array response function and detection capability for relatively high frequency (2-4 Hz) signals. Such signals are usually generated by events at distances within 1000 km and often lack energy in the lower frequency bands for which the larger aperture arrays provide signal coherence. These so-called regional signals are of increasing importance in civil applications and the need to characterize the infrasonic wavefield over these distances is increasingly important in the remote monitoring of natural hazards. I37NO will provide good characterization of Ground Truth industrial and military explosions in the region which are well-constrained by seismic data. The full array aperture provides excellent backazimuth and slowness resolution for lower frequency signals and it is anticipated that I37NO will contribute significantly to the detection and association of signals on a global scale. Already within the first few months of operation, we have examples of high-quality recordings from meteors, accidental

  16. Investigation of the impact of annealing on global molecular mobility in glasses: optimization for stabilization of amorphous pharmaceuticals.

    PubMed

    Luthra, Suman A; Hodge, Ian M; Pikal, Michael J

    2008-09-01

    The purpose of this research was to investigate the effect of annealing on the molecular mobility in lyophilized glasses using differential scanning calorimetry (DSC) and isothermal microcalorimetry (IMC) techniques. A second objective that emerged was a systematic study of the unusual pre-T(g) thermal events that were observed during DSC warming scans after annealing. Aspartame lyophilized with three different excipients; sucrose, trehalose and poly vinyl pyrrolidone (PVP) was studied. The aim of this work was to quantify the decrease in mobility in amorphous lyophilized aspartame formulations upon systematic postlyophilization annealing. DSC scans of aspartame:sucrose formulation (T(g) = 73 degrees C) showed the presence of a pre-T(g) endotherm which disappeared upon annealing. Aspartame:trehalose (T(g) = 112 degrees C) and aspartame:PVP (T(g) = 100 degrees C) showed a broad exotherm before T(g) and annealing caused appearance of endothermic peaks before T(g). This work also employed IMC to measure the global molecular mobility represented by structural relaxation time (tau(beta)) in both un-annealed and annealed formulations. The effect of annealing on the enthalpy relaxation of lyophilized glasses, as measured by DSC and IMC, was consistent with the behavior predicted using the Tool-Narayanaswamy-Moynihan (TNM) phenomenology (Luthra et al., 2007, in press). The results show that the systems annealed at T(g) -15 degrees C to T(g) -20 degrees C have the lowest molecular mobility. PMID:18200533

  17. Global Analysis of Carbon Sources and Sinks with a Comprehensive Model Optimized with GOSAT/Tanso Observations

    NASA Astrophysics Data System (ADS)

    Denning, A.; Lokupitiya, R. S.; Zupanski, D.; Kawa, S. R.; Baker, D. F.; Doney, S. C.; Gurney, K. R.

    2009-12-01

    We present a system to analyze GOSAT/Tanso data using a combination of existing models of CO2 exchanges due to hourly photosynthesis and respiration, daily air-sea gas exchange, biomass burning, Fossil Fuel Emissions, and atmospheric transport. This comprehensive system allows direct comparison to the observed record of both in-situ and remotely sensed atmospheric CO2 at hourly timescales. We have previously demonstrated that a lower-resolution version of the system has good skill at replicating diurnal, synoptic, and seasonal variations over vegetated land surfaces. The system is driven by meteorological output from the NASA Goddard EOS Data Assimilation System, version 5. Surface weather from the system drives calculations of terrestrial ecosystem metabolism (radiation, precipitation, humidity, temperature) and air-sea gas exchange (wind), with other input data coming from satellite data products (e.g., fPAR and LAI from MODIS, and ocean color from SeaWiFS and MODIS). The analysis system is evaluated using synthetic data on a 2 x 2.5 degree (lat x lon) global grid. Synthetic data are sampled in cloud-free columns along the GOSAT orbital ephemeris and used to estimate multiplicative biases to component fluxes by Ensemble Data Assimilation. The system is quite successful at retrieving mechanistic estimates of spatial patterns of surface carbon fluxes on monthly and annual timescales over land, but is less skillful over the oceans.

  18. Optimal wavelengths obtained from laws analogous to the Wien's law for monospectral and bispectral methods, and general methodology for multispectral temperature measurements taking into account global transfer function including non-uniform emissivity of surfaces

    NASA Astrophysics Data System (ADS)

    Rodiet, Christophe; Remy, Benjamin; Degiovanni, Alain

    2016-05-01

    In this paper, it is shown how to select the optimal wavelengths minimizing the relative error and the standard deviation of the temperature. Furthermore, it is shown that the optimal wavelengths in mono-spectral and bi-spectral methods (for a Planck's law) can be determined by laws analogous to the displacement Wien's law. The simplicity of these laws can thus allow real-time selection of optimal wavelengths for a control/optimization of industrial processes, for example. A more general methodology to obtain the optimal wavelengths selection in a multi-spectral method (taking into account the spectral variations of the global transfer function including the emissivity variations) for temperature measurement of surfaces exhibiting non-uniform emissivity, is also presented. This latter can then find an interest in glass furnaces temperature measurement with spatiotemporal non-uniformities of emissivity, the control of biomass pyrolysis, the surface temperature measurement of buildings or heating devices, for example. The goal consists of minimizing the standard deviation of the estimated temperature (optimal design experiment). For the multi-spectral method, two cases will be treated: optimal global and optimal constrained wavelengths selection (to the spectral range of the detector, for example). The estimated temperature results obtained by different models and for different number of parameters and wavelengths are compared. These different points are treated from theoretical, numerical and experimental points of view.

  19. Automatic and global optimization of the Analogue Method for statistical downscaling of precipitation - Which parameters can be determined by Genetic Algorithms?

    NASA Astrophysics Data System (ADS)

    Horton, Pascal; Weingartner, Rolf; Obled, Charles; Jaboyedoff, Michel

    2016-04-01

    The Analogue Method (AM) aims at forecasting a local meteorological variable of interest (the predictand), often the daily precipitation total, on the basis of a statistical relationship with synoptic predictor variables. A certain number of similar situations are sampled in order to establish the empirical conditional distribution which is considered as the prediction for a given date. The method is used in operational medium-range forecasting in several hydropower companies or flood forecasting services, as well as in climate impact studies. The statistical relationship is usually established by means of a semi-automatic sequential procedure that has strong limitations: it is made of successive steps and thus cannot handle parameters dependencies, and it cannot automatically optimize certain parameters, such as the selection of the pressure levels and the temporal windows on which the predictors are compared. A global optimization technique based on Genetic Algorithms was introduced in order to surpass these limitations and to provide a fully automatic and objective determination of the AM parameters. The parameters that were previously assessed manually, such as the selection of the pressure levels and the temporal windows, on which the predictors are compared, are now automatically determined. The next question is: Are Genetic Algorithms able to select the meteorological variable, in a reanalysis dataset, that is the best predictor for the considered predictand, along with the analogy criteria itself? Even though we may not find better predictors for precipitation prediction that the ones often used in Europe, due to numerous other studies which consisted in systematic assessments, the ability of an automatic selection offers new perspectives in order to adapt the AM for new predictands or new regions under different meteorological influences.

  20. Metabolic flux ratio analysis and multi-objective optimization revealed a globally conserved and coordinated metabolic response of E. coli to paraquat-induced oxidative stress.

    PubMed

    Shen, Tie; Rui, Bin; Zhou, Hong; Zhang, Ximing; Yi, Yin; Wen, Han; Zheng, Haoran; Wu, Jihui; Shi, Yunyu

    2013-01-27

    The ability of a microorganism to adapt to changes in the environment, such as in nutrient or oxygen availability, is essential for its competitive fitness and survival. The cellular objective and the strategy of the metabolic response to an extreme environment are therefore of tremendous interest and, thus, have been increasingly explored. However, the cellular objective of the complex regulatory structure of the metabolic changes has not yet been fully elucidated and more details regarding the quantitative behaviour of the metabolic flux redistribution are required to understand the systems-wide biological significance of this response. In this study, the intracellular metabolic flux ratios involved in the central carbon metabolism were determined by fractional (13)C-labeling and metabolic flux ratio analysis (MetaFoR) of the wild-type E. coli strain JM101 at an oxidative environment in a chemostat. We observed a significant increase in the flux through phosphoenolpyruvate carboxykinase (PEPCK), phosphoenolpyruvate carboxylase (PEPC), malic enzyme (MEZ) and serine hydroxymethyltransferase (SHMT). We applied an ε-constraint based multi-objective optimization to investigate the trade-off relationships between the biomass yield and the generation of reductive power using the in silico iJR904 genome-scale model of E. coli K-12. The theoretical metabolic redistribution supports that the trans-hydrogenase pathway should not play a direct role in the defence mounted by E. coli against oxidative stress. The agreement between the measured ratio and the theoretical redistribution established the significance of NADPH synthesis as the goal of the metabolic reprogramming that occurs in response to oxidative stress. Our work presents a framework that combines metabolic flux ratio analysis and multi-objective optimization to investigate the metabolic trade-offs that occur under varied environmental conditions. Our results led to the proposal that the metabolic response of E

  1. Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience

    PubMed Central

    de Azambuja, Evandro; Bradbury, Ian; Saini, Kamal S.; Bines, José; Simon, Sergio D.; Dooren, Veerle Van; Aktan, Gursel; Pritchard, Kathleen I.; Wolff, Antonio C.; Smith, Ian; Jackisch, Christian; Lang, Istvan; Untch, Michael; Boyle, Frances; Xu, Binghe; Baselga, Jose; Perez, Edith A.; Piccart-Gebhart, Martine

    2013-01-01

    Purpose. This study measured the time taken for setting up the different facets of Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO), an international phase III study being conducted in 44 participating countries. Methods. Time to regulatory authority (RA) approval, time to ethics committee/institutional review board (EC/IRB) approval, time from study approval by EC/IRB to first randomized patient, and time from first to last randomized patient were prospectively collected in the ALTTO study. Analyses were conducted by grouping countries into either geographic regions or economic classes as per the World Bank's criteria. Results. South America had a significantly longer time to RA approval (median: 236 days, range: 21–257 days) than Europe (median: 52 days, range: 0–151 days), North America (median: 26 days, range: 22–30 days), and Asia-Pacific (median: 62 days, range: 37–75 days). Upper-middle economies had longer times to RA approval (median: 123 days, range: 21–257 days) than high-income (median: 47 days, range: 0–112 days) and lower-middle income economies (median: 57 days, range: 37–62 days). No significant difference was observed for time to EC/IRB approval across the studied regions (median: 59 days, range 0–174 days). Overall, the median time from EC/IRB approval to first recruited patient was 169 days (range: 26–412 days). Conclusion. This study highlights the long time intervals required to activate a global phase III trial. Collaborative research groups, pharmaceutical industry sponsors, and regulatory authorities should analyze the current system and enter into dialogue for optimizing local policies. This would enable faster access of patients to innovative therapies and enhance the efficiency of clinical research. PMID:23359433

  2. Optimizing Clinical Operations as part of a Global Emergency Medicine Initiative in Kumasi, Ghana: Application of Lean Manufacturing Principals to Low Resource Health Systems

    PubMed Central

    Carter, Patrick M.; Desmond, Jeffery S.; Akanbobnaab, Christopher; Oteng, Rockefeller A.; Rominski, Sarah; Barsan, William G.; Cunningham, Rebecca

    2012-01-01

    Background Although many global health programs focus on providing clinical care or medical education, improving clinical operations can have a significant effect on patient care delivery, especially in developing health systems without high-level operations management. Lean manufacturing techniques have been effective in decreasing emergency department (ED) length of stay, patient waiting times, numbers of patients leaving without being seen, and door-to-balloon times for ST-elevation myocardial infarction in developed health systems; but use of Lean in low to middle income countries with developing emergency medicine systems has not been well characterized. Objectives To describe the application of Lean manufacturing techniques to improve clinical operations at Komfo Anokye Teaching Hospital in Ghana and to identify key lessons learned to aid future global EM initiatives. Methods A three-week Lean improvement program focused on the hospital admissions process at Komfo Anokye Teaching Hospital was completed by a 14-person team in six stages: problem definition, scope of project planning, value stream mapping, root cause analysis, future state planning, and implementation planning. Results The authors identified eight lessons learned during our use of Lean to optimize the operations of an ED in a global health setting: 1) the Lean process aided in building a partnership with Ghanaian colleagues; 2) obtaining and maintaining senior institutional support is necessary and challenging; 3) addressing power differences among the team to obtain feedback from all team members is critical to successful Lean analysis; 4) choosing a manageable initial project is critical to influence long-term Lean use in a new environment; 5) data intensive Lean tools can be adapted and are effective in a less resourced health system; 6) several Lean tools focused on team problem solving techniques worked well in a low resource system without modification; 7) using Lean highlighted that

  3. Density functional theory and global optimization study of Sn(m)Pb(n) clusters (7 ≤ m + n ≤ 12, 0 ≤ m/(m + n) ≤ 1).

    PubMed

    Orel, Slava; Fournier, René

    2013-02-14

    The global minima of the neutral binary Sn(m)Pb(n) atomic clusters, 7 ≤ m + n ≤ 12, of all the possible stoichiometric ratios have been found using tabu search in descriptor space and density functional theory. The effects of spin-orbit coupling on optimized geometries and energies are important. All of the binary clusters form substitution alloys. Apart from the 11-atom case, the pure clusters of the same size have the same ground state geometry. The relative energies of the isomers of a cluster depend on, in order of decreasing importance: the overall geometry; the specific sites occupied by the two atom types; and the degree of segregation. The total cohesive energy difference between the lowest energy homotops is typically on the order of 0.02 eV. The mixing/segregation trends are found to be very different depending on the size of the basis set. Calculations generally overestimate the dipole moments. The trends in calculated dipole moments agree with experiment for the lead-rich clusters, and to a lesser degree, the tin-rich clusters. PMID:23425470

  4. Density functional theory and global optimization study of SnmPbn clusters (7 ⩽ m + n ⩽ 12, 0 ⩽ m/(m + n) ⩽ 1)

    NASA Astrophysics Data System (ADS)

    Orel, Slava; Fournier, René

    2013-02-01

    The global minima of the neutral binary SnmPbn atomic clusters, 7 ⩽ m + n ⩽ 12, of all the possible stoichiometric ratios have been found using tabu search in descriptor space and density functional theory. The effects of spin-orbit coupling on optimized geometries and energies are important. All of the binary clusters form substitution alloys. Apart from the 11-atom case, the pure clusters of the same size have the same ground state geometry. The relative energies of the isomers of a cluster depend on, in order of decreasing importance: the overall geometry; the specific sites occupied by the two atom types; and the degree of segregation. The total cohesive energy difference between the lowest energy homotops is typically on the order of 0.02 eV. The mixing/segregation trends are found to be very different depending on the size of the basis set. Calculations generally overestimate the dipole moments. The trends in calculated dipole moments agree with experiment for the lead-rich clusters, and to a lesser degree, the tin-rich clusters.

  5. Pseudo-transient Continuation Based Variable Relaxation Solve in Nonlinear Magnetohydrodynamic Simulations

    SciTech Connect

    Jin Chen

    2009-12-07

    Efficient and robust Variable Relaxation Solver, based on pseudo-transient continuation, is developed to solve nonlinear anisotropic thermal conduction arising from fusion plasma simulations. By adding first and/or second order artificial time derivatives to the system, this type of method advances the resulting time-dependent nonlinear PDEs to steady state, which is the solution to be sought. In this process, only the stiffness matrix itself is involved so that the numerical complexity and errors can be greatly reduced. In fact, this work is an extension of integrating efficient linear elliptic solvers for fusion simulation on Cray XIE. Two schemes are derived in this work, first and second order Variable Relaxations. Four factors are observed to be critical for efficiency and preservation of solution's symmetric structure arising from periodic boundary condition: refining meshes in different coordinate directions, initializing nonlinear process, varying time steps in both temporal and spatial directions, and accurately generating nonlinear stiffness matrix. First finer mesh scale should be taken in strong transport direction; Next the system is carefully initialized by the solution with linear conductivity; Third, time step and relaxation factor are vertex-based varied and optimized at each time step; Finally, the nonlinear stiffness matrix is updated by just scaling corresponding linear one with the vector generated from nonlinear thermal conductivity.

  6. Beyond Medical "Missions" to Impact-Driven Short-Term Experiences in Global Health (STEGHs): Ethical Principles to Optimize Community Benefit and Learner Experience.

    PubMed

    Melby, Melissa K; Loh, Lawrence C; Evert, Jessica; Prater, Christopher; Lin, Henry; Khan, Omar A

    2016-05-01

    Increasing demand for global health education in medical training has driven the growth of educational programs predicated on a model of short-term medical service abroad. Almost two-thirds of matriculating medical students expect to participate in a global health experience during medical school, continuing into residency and early careers. Despite positive intent, such short-term experiences in global health (STEGHs) may exacerbate global health inequities and even cause harm. Growing out of the "medical missions" tradition, contemporary participation continues to evolve. Ethical concerns and other disciplinary approaches, such as public health and anthropology, can be incorpo rated to increase effectiveness and sustainability, and to shift the culture of STEGHs from focusing on trainees and their home institutions to also considering benefits in host communities and nurtur ing partnerships. The authors propose four core principles to guide ethical development of educational STEGHs: (1) skills building in cross-cultural effective ness and cultural humility, (2) bidirectional participatory relationships, (3) local capacity building, and (4) long-term sustainability. Application of these principles highlights the need for assessment of STEGHs: data collection that allows transparent compar isons, standards of quality, bidirectionality of agreements, defined curricula, and ethics that meet both host and sending countries' standards and needs. To capture the enormous potential of STEGHs, a paradigm shift in the culture of STEGHs is needed to ensure that these experiences balance training level, personal competencies, medical and cross-cultural ethics, and educational objectives to minimize harm and maximize benefits for all involved. PMID:26630608

  7. A Salzburg Global Seminar: "Optimizing Talent: Closing Education and Social Mobility Gaps Worldwide." Policy Notes. Volume 20, Number 3, Fall 2012

    ERIC Educational Resources Information Center

    Schwartz, Robert

    2012-01-01

    This issue of ETS Policy Notes (Vol. 20, No. 3) provides highlights from the Salzburg Global Seminar in December 2011. The seminar focused on bettering the educational and life prospects of students up to age 18 worldwide. [This article was written with the assistance of Beth Brody.

  8. Global water cycle

    NASA Technical Reports Server (NTRS)

    Robertson, Franklin; Goodman, Steven J.; Christy, John R.; Fitzjarrald, Daniel E.; Chou, Shi-Hung; Crosson, William; Wang, Shouping; Ramirez, Jorge

    1993-01-01

    This research is the MSFC component of a joint MSFC/Pennsylvania State University Eos Interdisciplinary Investigation on the global water cycle extension across the earth sciences. The primary long-term objective of this investigation is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates change on both global and regional scales. Significant accomplishments in the past year are presented and include the following: (1) water vapor variability; (2) multi-phase water analysis; (3) global modeling; and (4) optimal precipitation and stream flow analysis and hydrologic processes.

  9. Optimal Coordination and Synchronization in Local Air Quality and GHG Emissions: An Economic Study of Multiple Gases Issue in Integrated Assessment of Global Change

    SciTech Connect

    Yang, Zili

    2009-03-19

    In the duration of this project, we finished the main tasks set up in the initial proposal. These tasks include: collecting needed data of regional aerosol emissions (mainly SO2); building the RICES model; conducting preliminary simulation runs on some policy scenarios. We established a unified and transparent IA modeling platform that connecting climate change and local air pollution. The RICES model is the pioneering IA model that treats climate change and local air pollution as correlated global and local stock externalities.

  10. Selecting the optimal method to calculate daily global reference potential evaporation from CFSR reanalysis data for application in a hydrological model study

    NASA Astrophysics Data System (ADS)

    Sperna Weiland, F. C.; Tisseuil, C.; Dürr, H. H.; Vrac, M.; van Beek, L. P. H.

    2012-03-01

    Potential evaporation (PET) is one of the main inputs of hydrological models. Yet, there is limited consensus on which PET equation is most applicable in hydrological climate impact assessments. In this study six different methods to derive global scale reference PET daily time series from Climate Forecast System Reanalysis (CFSR) data are compared: Penman-Monteith, Priestley-Taylor and original and re-calibrated versions of the Hargreaves and Blaney-Criddle method. The calculated PET time series are (1) evaluated against global monthly Penman-Monteith PET time series calculated from CRU data and (2) tested on their usability for modeling of global discharge cycles. A major finding is that for part of the investigated basins the selection of a PET method may have only a minor influence on the resulting river flow. Within the hydrological model used in this study the bias related to the PET method tends to decrease while going from PET, AET and runoff to discharge calculations. However, the performance of individual PET methods appears to be spatially variable, which stresses the necessity to select the most accurate and spatially stable PET method. The lowest root mean squared differences and the least significant deviations (95% significance level) between monthly CFSR derived PET time series and CRU derived PET were obtained for a cell-specific re-calibrated Blaney-Criddle equation. However, results show that this re-calibrated form is likely to be unstable under changing climate conditions and less reliable for the calculation of daily time series. Although often recommended, the Penman-Monteith equation applied to the CFSR data did not outperform the other methods in a evaluation against PET derived with the Penman-Monteith equation from CRU data. In arid regions (e.g. Sahara, central Australia, US deserts), the equation resulted in relatively low PET values and, consequently, led to relatively high discharge values for dry basins (e.g. Orange, Murray and

  11. Optimizing and Interpreting Insular Functional Connectivity Maps Obtained During Acute Experimental Pain: The Effects of Global Signal and Task Paradigm Regression.

    PubMed

    Ibinson, James W; Vogt, Keith M; Taylor, Kevin B; Dua, Shiv B; Becker, Christopher J; Loggia, Marco; Wasan, Ajay D

    2015-12-01

    The insula is uniquely located between the temporal and parietal cortices, making it anatomically well-positioned to act as an integrating center between the sensory and affective domains for the processing of painful stimulation. This can be studied through resting-state functional connectivity (fcMRI) imaging; however, the lack of a clear methodology for the analysis of fcMRI complicates the interpretation of these data during acute pain. Detected connectivity changes may reflect actual alterations in low-frequency synchronous neuronal activity related to pain, may be due to changes in global cerebral blood flow or the superimposed task-induced neuronal activity. The primary goal of this study was to investigate the effects of global signal regression (GSR) and task paradigm regression (TPR) on the changes in functional connectivity of the left (contralateral) insula in healthy subjects at rest and during acute painful electric nerve stimulation of the right hand. The use of GSR reduced the size and statistical significance of connectivity clusters and created negative correlation coefficients for some connectivity clusters. TPR with cyclic stimulation gave task versus rest connectivity differences similar to those with a constant task, suggesting that analysis which includes TPR is more accurately reflective of low-frequency neuronal activity. Both GSR and TPR have been inconsistently applied to fcMRI analysis. Based on these results, investigators need to consider the impact GSR and TPR have on connectivity during task performance when attempting to synthesize the literature. PMID:26061382

  12. Mechanistic site-based emulation of a global ocean biogeochemical model (MEDUSA 1.0) for parametric analysis and calibration: an application of the Marine Model Optimization Testbed (MarMOT 1.1)

    NASA Astrophysics Data System (ADS)

    Hemmings, J. C. P.; Challenor, P. G.; Yool, A.

    2015-03-01

    Biogeochemical ocean circulation models used to investigate the role of plankton ecosystems in global change rely on adjustable parameters to capture the dominant biogeochemical dynamics of a complex biological system. In principle, optimal parameter values can be estimated by fitting models to observational data, including satellite ocean colour products such as chlorophyll that achieve good spatial and temporal coverage of the surface ocean. However, comprehensive parametric analyses require large ensemble experiments that are computationally infeasible with global 3-D simulations. Site-based simulations provide an efficient alternative but can only be used to make reliable inferences about global model performance if robust quantitative descriptions of their relationships with the corresponding 3-D simulations can be established. The feasibility of establishing such a relationship is investigated for an intermediate complexity biogeochemistry model (MEDUSA) coupled with a widely used global ocean model (NEMO). A site-based mechanistic emulator is constructed for surface chlorophyll output from this target model as a function of model parameters. The emulator comprises an array of 1-D simulators and a statistical quantification of the uncertainty in their predictions. The unknown parameter-dependent biogeochemical environment, in terms of initial tracer concentrations and lateral flux information required by the simulators, is a significant source of uncertainty. It is approximated by a mean environment derived from a small ensemble of 3-D simulations representing variability of the target model behaviour over the parameter space of interest. The performance of two alternative uncertainty quantification schemes is examined: a direct method based on comparisons between simulator output and a sample of known target model "truths" and an indirect method that is only partially reliant on knowledge of the target model output. In general, chlorophyll records at a

  13. A Full-Envelope Air Data Calibration and Three-Dimensional Wind Estimation Method Using Global Output-Error Optimization and Flight-Test Techniques

    NASA Technical Reports Server (NTRS)

    Taylor, Brian R.

    2012-01-01

    A novel, efficient air data calibration method is proposed for aircraft with limited envelopes. This method uses output-error optimization on three-dimensional inertial velocities to estimate calibration and wind parameters. Calibration parameters are based on assumed calibration models for static pressure, angle of attack, and flank angle. Estimated wind parameters are the north, east, and down components. The only assumptions needed for this method are that the inertial velocities and Euler angles are accurate, the calibration models are correct, and that the steady-state component of wind is constant throughout the maneuver. A two-minute maneuver was designed to excite the aircraft over the range of air data calibration parameters and de-correlate the angle-of-attack bias from the vertical component of wind. Simulation of the X-48B (The Boeing Company, Chicago, Illinois) aircraft was used to validate the method, ultimately using data derived from wind-tunnel testing to simulate the un-calibrated air data measurements. Results from the simulation were accurate and robust to turbulence levels comparable to those observed in flight. Future experiments are planned to evaluate the proposed air data calibration in a flight environment.

  14. The global energy system.

    PubMed

    Häfele, W; Sassin, W

    1979-05-01

    A global energy system is conceptualized and analyzed, the energy distributor sub-system of the worldwide supranational system. Its many interconnections are examined and traced back to their source to determine the major elements of this global energy system. Long-term trends are emphasized. The analysis begins with a discussion of the local systems that resulted from the deployment of technology in the mid-nineteenth century, continues with a description of the global system based on oil that has existed for the past two decades, and ends with a scenario implying that an energy transition will occur in the future in which use of coal, nuclear, and solar energy will predominate. A major problem for the future will be the management of this energy transition. The optimal use of global resources and the efficient management of this transition will require a stable and persistent global order. PMID:464990

  15. Global optimization of data quality checks on 2-D and 3-D networks of GPR cross-well tomographic data for automatic correction of unknown well deviations

    SciTech Connect

    Sassen, D. S.; Peterson, J. E.

    2010-03-15

    .g. Bautu et al., 2006). In the technique of algebraic reconstruction tomography (ART), which is used herein for the travel time inversion (Peterson et al., 1985), a small relaxation parameter will smooth imaging artifacts caused by data errors at the expense of resolution and contrast (Figure 2). However, large data errors such as unaccounted well deviations cannot be adequately suppressed through inversion weighting schemes. Previously, problems with tomograms were treated manually. However, in large data sets and/or networks of data sets, trial and error changes to well geometries become increasingly difficult and ineffective. Mislocation of the transmitter and receiver stations of GPR cross-well tomography data sets can lead to serious imaging artifacts if not accounted for prior to inversion. Previously, problems with tomograms have been treated manually prior to inversion. In large data sets and/or networks of tomographic data sets, trial and error changes to well geometries become increasingly difficult and ineffective. Our approach is to use cross-well data quality checks and a simplified model of borehole deviation with particle swarm optimization (PSO) to automatically correct for source and receiver locations prior to tomographic inversion. We present a simple model of well deviation, which is designed to minimize potential corruption of actual data trends. We also provide quantitative quality control measures based on minimizing correlations between take-off angle and apparent velocity, and a quality check on the continuity of velocity between adjacent wells. This methodology is shown to be accurate and robust for simple 2-D synthetic test cases. Plus, we demonstrate the method on actual field data where it is compared to deviation logs. This study shows the promise for automatic correction of well deviations in GPR tomographic data. Analysis of synthetic data shows that very precise estimates of well deviation can be made for small deviations, even in the

  16. Global Education.

    ERIC Educational Resources Information Center

    Longstreet, Wilma S., Ed.

    1988-01-01

    This issue contains an introduction ("The Promise and Perplexity of Globalism," by W. Longstreet) and seven articles dedicated to exploring the meaning of global education for today's schools. "Global Education: An Overview" (J. Becker) develops possible definitions, identifies objectives and skills, and addresses questions and issues in this…

  17. Global Science.

    ERIC Educational Resources Information Center

    Brophy, Michael

    1991-01-01

    Approaches taken by a school science department to implement a global science curriculum using a range of available resources are outlined. Problems with current curriculum approaches, alternatives to an ethnocentric curriculum, advantages of global science, and possible strategies for implementing a global science policy are discussed. (27…

  18. Global Education.

    ERIC Educational Resources Information Center

    Berkley, June, Ed.

    1982-01-01

    The articles in this collection deal with various methods of global education--education to prepare students to function as understanding and informed citizens of the world. Topics discussed in the 26 articles include: (1) the necessity of global education; (2) global education in the elementary school language arts curriculum; (3) science fiction…

  19. Global HRD.

    ERIC Educational Resources Information Center

    1997

    This document contains four papers from a symposium on global human resource development (HRD). "Globalization of Human Resource Management (HRM) in Government: A Cross-Cultural Perspective" (Pan Suk Kim) relates HRM to national cultures and addresses its specific functional aspects with a unique dimension in a global organization. "An…

  20. Global interrupt and barrier networks

    DOEpatents

    Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E; Heidelberger, Philip; Kopcsay, Gerard V.; Steinmacher-Burow, Burkhard D.; Takken, Todd E.

    2008-10-28

    A system and method for generating global asynchronous signals in a computing structure. Particularly, a global interrupt and barrier network is implemented that implements logic for generating global interrupt and barrier signals for controlling global asynchronous operations performed by processing elements at selected processing nodes of a computing structure in accordance with a processing algorithm; and includes the physical interconnecting of the processing nodes for communicating the global interrupt and barrier signals to the elements via low-latency paths. The global asynchronous signals respectively initiate interrupt and barrier operations at the processing nodes at times selected for optimizing performance of the processing algorithms. In one embodiment, the global interrupt and barrier network is implemented in a scalable, massively parallel supercomputing device structure comprising a plurality of processing nodes interconnected by multiple independent networks, with each node including one or more processing elements for performing computation or communication activity as required when performing parallel algorithm operations. One multiple independent network includes a global tree network for enabling high-speed global tree communications among global tree network nodes or sub-trees thereof. The global interrupt and barrier network may operate in parallel with the global tree network for providing global asynchronous sideband signals.

  1. Optimization of evaporative cooling

    NASA Astrophysics Data System (ADS)

    Sackett, C. A.; Bradley, C. C.; Hulet, R. G.

    1997-05-01

    Recent experiments have used forced evaporative cooling to produce Bose-Einstein condensation in dilute gases. The evaporative cooling process can be optimized to provide the maximum phase-space density with a specified number of atoms remaining. We show that this global optimization is approximately achieved by locally optimizing the cooling efficiency at each instant. We discuss how this method can be implemented, and present the results for our 7Li trap. The predicted behavior of the gas is found to agree well with experiment.

  2. Global water cycle

    NASA Technical Reports Server (NTRS)

    Robertson, Franklin R.; Christy, John R.; Goodman, Steven J.; Miller, Tim L.; Fitzjarrald, Dan; Lapenta, Bill; Wang, Shouping

    1991-01-01

    The primary objective is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates changes on both global and regional scales. The following subject areas are covered: (1) water vapor variability; (2) multi-phase water analysis; (3) diabatic heating; (4) MSU (Microwave Sounding Unit) temperature analysis; (5) Optimal precipitation and streamflow analysis; (6) CCM (Community Climate Model) hydrological cycle; (7) CCM1 climate sensitivity to lower boundary forcing; and (8) mesoscale modeling of atmosphere/surface interaction.

  3. Nonlinear model predictive control based on collective neurodynamic optimization.

    PubMed

    Yan, Zheng; Wang, Jun

    2015-04-01

    In general, nonlinear model predictive control (NMPC) entails solving a sequential global optimization problem with a nonconvex cost function or constraints. This paper presents a novel collective neurodynamic optimization approach to NMPC without linearization. Utilizing a group of recurrent neural networks (RNNs), the proposed collective neurodynamic optimization approach searches for optimal solutions to global optimization problems by emulating brainstorming. Each RNN is guaranteed to converge to a candidate solution by performing constrained local search. By exchanging information and iteratively improving the starting and restarting points of each RNN using the information of local and global best known solutions in a framework of particle swarm optimization, the group of RNNs is able to reach global optimal solutions to global optimization problems. The essence of the proposed collective neurodynamic optimization approach lies in the integration of capabilities of global search and precise local search. The simulation results of many cases are discussed to substantiate the effectiveness and the characteristics of the proposed approach. PMID:25608315

  4. Algorithms for bilevel optimization

    NASA Technical Reports Server (NTRS)

    Alexandrov, Natalia; Dennis, J. E., Jr.

    1994-01-01

    General multilevel nonlinear optimization problems arise in design of complex systems and can be used as a means of regularization for multi-criteria optimization problems. Here, for clarity in displaying our ideas, we restrict ourselves to general bi-level optimization problems, and we present two solution approaches. Both approaches use a trust-region globalization strategy, and they can be easily extended to handle the general multilevel problem. We make no convexity assumptions, but we do assume that the problem has a nondegenerate feasible set. We consider necessary optimality conditions for the bi-level problem formulations and discuss results that can be extended to obtain multilevel optimization formulations with constraints at each level.

  5. Global Composite

    Atmospheric Science Data Center

    2013-04-19

    article title:  MISR Global Images See the Light of Day     View Larger Image ... than its nadir counterpart due to enhanced reflection of light by atmospheric particulates. MISR data are processed at the ...

  6. Terascale Optimal PDE Simulations

    SciTech Connect

    David Keyes

    2009-07-28

    The Terascale Optimal PDE Solvers (TOPS) Integrated Software Infrastructure Center (ISIC) was created to develop and implement algorithms and support scientific investigations performed by DOE-sponsored researchers. These simulations often involve the solution of partial differential equations (PDEs) on terascale computers. The TOPS Center researched, developed and deployed an integrated toolkit of open-source, optimal complexity solvers for the nonlinear partial differential equations that arise in many DOE application areas, including fusion, accelerator design, global climate change and reactive chemistry. The algorithms created as part of this project were also designed to reduce current computational bottlenecks by orders of magnitude on terascale computers, enabling scientific simulation on a scale heretofore impossible.

  7. Dynamic Optimization

    NASA Technical Reports Server (NTRS)

    Laird, Philip

    1992-01-01

    We distinguish static and dynamic optimization of programs: whereas static optimization modifies a program before runtime and is based only on its syntactical structure, dynamic optimization is based on the statistical properties of the input source and examples of program execution. Explanation-based generalization is a commonly used dynamic optimization method, but its effectiveness as a speedup-learning method is limited, in part because it fails to separate the learning process from the program transformation process. This paper describes a dynamic optimization technique called a learn-optimize cycle that first uses a learning element to uncover predictable patterns in the program execution and then uses an optimization algorithm to map these patterns into beneficial transformations. The technique has been used successfully for dynamic optimization of pure Prolog.

  8. Singularity in structural optimization

    NASA Technical Reports Server (NTRS)

    Patnaik, S. N.; Guptill, J. D.; Berke, L.

    1993-01-01

    The conditions under which global and local singularities may arise in structural optimization are examined. Examples of these singularities are presented, and a framework is given within which the singularities can be recognized. It is shown, in particular, that singularities can be identified through the analysis of stress-displacement relations together with compatibility conditions or the displacement-stress relations derived by the integrated force method of structural analysis. Methods of eliminating the effects of singularities are suggested and illustrated numerically.

  9. HOMER® Micropower Optimization Model

    SciTech Connect

    Lilienthal, P.

    2005-01-01

    NREL has developed the HOMER micropower optimization model. The model can analyze all of the available small power technologies individually and in hybrid configurations to identify least-cost solutions to energy requirements. This capability is valuable to a diverse set of energy professionals and applications. NREL has actively supported its growing user base and developed training programs around the model. These activities are helping to grow the global market for solar technologies.

  10. Global Simulation of Aviation Operations

    NASA Technical Reports Server (NTRS)

    Sridhar, Banavar; Sheth, Kapil; Ng, Hok Kwan; Morando, Alex; Li, Jinhua

    2016-01-01

    The simulation and analysis of global air traffic is limited due to a lack of simulation tools and the difficulty in accessing data sources. This paper provides a global simulation of aviation operations combining flight plans and real air traffic data with historical commercial city-pair aircraft type and schedule data and global atmospheric data. The resulting capability extends the simulation and optimization functions of NASA's Future Air Traffic Management Concept Evaluation Tool (FACET) to global scale. This new capability is used to present results on the evolution of global air traffic patterns from a concentration of traffic inside US, Europe and across the Atlantic Ocean to a more diverse traffic pattern across the globe with accelerated growth in Asia, Australia, Africa and South America. The simulation analyzes seasonal variation in the long-haul wind-optimal traffic patterns in six major regions of the world and provides potential time-savings of wind-optimal routes compared with either great circle routes or current flight-plans if available.

  11. Global militarization

    SciTech Connect

    Wallensteen, P.; Galtung, J.; Portales, C.

    1985-01-01

    This book contains 10 chapters. Some of the titles are: Military Formations and Social Formations: A Structural Analysis; Global Conflict Formations: Present Developments and Future Directions; War and the Power of Warmakers in Western Europe and Elsewhere, 1600-1980; and The Urban Type of Society and International War.

  12. Global Warming?

    ERIC Educational Resources Information Center

    Eichman, Julia Christensen; Brown, Jeff A.

    1994-01-01

    Presents information and data on an experiment designed to test whether different atmosphere compositions are affected by light and temperature during both cooling and heating. Although flawed, the experiment should help students appreciate the difficulties that researchers face when trying to find evidence of global warming. (PR)

  13. Global Education.

    ERIC Educational Resources Information Center

    McCoubrey, Sharon

    1994-01-01

    This theme issue focuses on topics related to global issues. (1) "Recycling for Art Projects" (Wendy Stephenson) gives an argument for recycling in the art classroom; (2) "Winds of Change: Tradition and Innovation in Circumpolar Art" (Bill Zuk and Robert Dalton) includes profiles of Alaskan Yupik artist, Larry Beck, who creates art from recycled…

  14. Campus Global.

    ERIC Educational Resources Information Center

    Sort, Josep

    2003-01-01

    Describes the development of the Campus Global portal at a public university in Spain. The project aimed to change the ways in which the university community worked, taught, and learned. Examines how the project was carried out, the transformations it instigated inside the organization, the improvements it has brought about, and the current state…

  15. Panwapa: Global Kids, Global Connections

    ERIC Educational Resources Information Center

    Berson, Ilene R.; Berson, Michael J.

    2009-01-01

    Panwapa, created by the Sesame Street Workshop of PBS, is an example of an initiative on the Internet designed to enhance students' learning by exposing them to global communities. Panwapa means "Here on Earth" in Tshiluba, a Bantu language spoken in the Democratic Republic of Congo. At the Panwapa website, www.panwapa.org, children aged four to…

  16. Going Global

    ERIC Educational Resources Information Center

    Boulard, Garry

    2010-01-01

    In a move to increase its out-of-state and international student enrollment, officials at the University of Iowa are stepping up their global recruitment efforts--even in the face of criticism that the school may be losing sight of its mission. The goal is to increase enrollment across the board, with both in-state as well as out-of-state and…

  17. Global Arrays

    SciTech Connect

    2006-02-23

    The Global Arrays (GA) toolkit provides an efficient and portable “shared-memory” programming interface for distributed-memory computers. Each process in a MIMD parallel program can asynchronously access logical blocks of physically distributed dense multi-dimensional arrays, without need for explicit cooperation by other processes. Unlike other shared-memory environments, the GA model exposes to the programmer the non-uniform memory access (NUMA) characteristics of the high performance computers and acknowledges that access to a remote portion of the shared data is slower than to the local portion. The locality information for the shared data is available, and a direct access to the local portions of shared data is provided. Global Arrays have been designed to complement rather than substitute for the message-passing programming model. The programmer is free to use both the shared-memory and message-passing paradigms in the same program, and to take advantage of existing message-passing software libraries. Global Arrays are compatible with the Message Passing Interface (MPI).

  18. Global Arrays

    Energy Science and Technology Software Center (ESTSC)

    2006-02-23

    The Global Arrays (GA) toolkit provides an efficient and portable “shared-memory” programming interface for distributed-memory computers. Each process in a MIMD parallel program can asynchronously access logical blocks of physically distributed dense multi-dimensional arrays, without need for explicit cooperation by other processes. Unlike other shared-memory environments, the GA model exposes to the programmer the non-uniform memory access (NUMA) characteristics of the high performance computers and acknowledges that access to a remote portion of the sharedmore » data is slower than to the local portion. The locality information for the shared data is available, and a direct access to the local portions of shared data is provided. Global Arrays have been designed to complement rather than substitute for the message-passing programming model. The programmer is free to use both the shared-memory and message-passing paradigms in the same program, and to take advantage of existing message-passing software libraries. Global Arrays are compatible with the Message Passing Interface (MPI).« less

  19. Dispositional Optimism

    PubMed Central

    Carver, Charles S.; Scheier, Michael F.

    2014-01-01

    Optimism is a cognitive construct (expectancies regarding future outcomes) that also relates to motivation: optimistic people exert effort, whereas pessimistic people disengage from effort. Study of optimism began largely in health contexts, finding positive associations between optimism and markers of better psychological and physical health. Physical health effects likely occur through differences in both health-promoting behaviors and physiological concomitants of coping. Recently, the scientific study of optimism has extended to the realm of social relations: new evidence indicates that optimists have better social connections, partly because they work harder at them. In this review, we examine the myriad ways this trait can benefit an individual, and our current understanding of the biological basis of optimism. PMID:24630971

  20. Environmental economics: Optimal carbon tax doubled

    NASA Astrophysics Data System (ADS)

    Warren, Rachel

    2014-07-01

    Cost-benefit analysis and risk assessment approaches inform global climate change mitigation policy-making processes. Now, a development in the former shows that optimal carbon tax levels have previously been underestimated by a factor of two.

  1. Optimal Foraging in Semantic Memory

    ERIC Educational Resources Information Center

    Hills, Thomas T.; Jones, Michael N.; Todd, Peter M.

    2012-01-01

    Do humans search in memory using dynamic local-to-global search strategies similar to those that animals use to forage between patches in space? If so, do their dynamic memory search policies correspond to optimal foraging strategies seen for spatial foraging? Results from a number of fields suggest these possibilities, including the shared…

  2. Distributed Optimization

    NASA Technical Reports Server (NTRS)

    Macready, William; Wolpert, David

    2005-01-01

    We demonstrate a new framework for analyzing and controlling distributed systems, by solving constrained optimization problems with an algorithm based on that framework. The framework is ar. information-theoretic extension of conventional full-rationality game theory to allow bounded rational agents. The associated optimization algorithm is a game in which agents control the variables of the optimization problem. They do this by jointly minimizing a Lagrangian of (the probability distribution of) their joint state. The updating of the Lagrange parameters in that Lagrangian is a form of automated annealing, one that focuses the multi-agent system on the optimal pure strategy. We present computer experiments for the k-sat constraint satisfaction problem and for unconstrained minimization of NK functions.

  3. Global teaching of global seismology

    NASA Astrophysics Data System (ADS)

    Stein, S.; Wysession, M.

    2005-12-01

    Our recent textbook, Introduction to Seismology, Earthquakes, & Earth Structure (Blackwell, 2003) is used in many countries. Part of the reason for this may be our deliberate attempt to write the book for an international audience. This effort appears in several ways. We stress seismology's long tradition of global data interchange. Our brief discussions of the science's history illustrate the contributions of scientists around the world. Perhaps most importantly, our discussions of earthquakes, tectonics, and seismic hazards take a global view. Many examples are from North America, whereas others are from other areas. Our view is that non-North American students should be exposed to North American examples that are type examples, and that North American students should be similarly exposed to examples elsewhere. For example, we illustrate how the Euler vector geometry changes a plate boundary from spreading, to strike-slip, to convergence using both the Pacific-North America boundary from the Gulf of California to Alaska and the Eurasia-Africa boundary from the Azores to the Mediterranean. We illustrate diffuse plate boundary zones using western North America, the Andes, the Himalayas, the Mediterranean, and the East Africa Rift. The subduction zone discussions examine Japan, Tonga, and Chile. We discuss significant earthquakes both in the U.S. and elsewhere, and explore hazard mitigation issues in different contexts. Both comments from foreign colleagues and our experience lecturing overseas indicate that this approach works well. Beyond the specifics of our text, we believe that such a global approach is facilitated by the international traditions of the earth sciences and the world youth culture that gives students worldwide common culture. For example, a video of the scene in New Madrid, Missouri that arose from a nonsensical earthquake prediction in 1990 elicits similar responses from American and European students.

  4. Global Geomorphology

    NASA Technical Reports Server (NTRS)

    Douglas, I.

    1985-01-01

    Any global view of landforms must include an evaluation of the link between plate tectonics and geomorphology. To explain the broad features of the continents and ocean floors, a basic distinction between the tectogene and cratogene part of the Earth's surface must be made. The tectogene areas are those that are dominated by crustal movements, earthquakes and volcanicity at the present time and are essentially those of the great mountain belts and mid ocean ridges. Cratogene areas comprise the plate interiors, especially the old lands of Gondwanaland and Laurasia. Fundamental as this division between plate margin areas and plate interiors is, it cannot be said to be a simple case of a distinction between tectonically active and stable areas. Indeed, in terms of megageomorphology, former plate margins and tectonic activity up to 600 million years ago have to be considered.

  5. Global gamesmanship.

    PubMed

    MacMillan, Ian C; van Putten, Alexander B; McGrath, Rita Gunther

    2003-05-01

    Competition among multinationals these days is likely to be a three-dimensional game of global chess: The moves an organization makes in one market are designed to achieve goals in another in ways that aren't immediately apparent to its rivals. The authors--all management professors-call this approach "competing under strategic interdependence," or CSI. And where this interdependence exists, the complexity of the situation can quickly overwhelm ordinary analysis. Indeed, most business strategists are terrible at anticipating the consequences of interdependent choices, and they're even worse at using interdependency to their advantage. In this article, the authors offer a process for mapping the competitive landscape and anticipating how your company's moves in one market can influence its competitive interactions in others. They outline the six types of CSI campaigns--onslaughts, contests, guerrilla campaigns, feints, gambits, and harvesting--available to any multiproduct or multimarket corporation that wants to compete skillfully. They cite real-world examples such as the U.S. pricing battle Philip Morris waged with R.J. Reynolds--not to gain market share in the domestic cigarette market but to divert R.J. Reynolds's resources and attention from the opportunities Philip Morris was pursuing in Eastern Europe. And, using data they collected from their studies of consumer-products companies Procter & Gamble and Unilever, the authors describe how to create CSI tables and bubble charts that present a graphical look at the competitive landscape and that may uncover previously hidden opportunities. The CSI mapping process isn't just for global corporations, the authors explain. Smaller organizations that compete with a portfolio of products in just one national or regional market may find it just as useful for planning their next business moves. PMID:12747163

  6. Global warming

    NASA Astrophysics Data System (ADS)

    Houghton, John

    2005-06-01

    'Global warming' is a phrase that refers to the effect on the climate of human activities, in particular the burning of fossil fuels (coal, oil and gas) and large-scale deforestation, which cause emissions to the atmosphere of large amounts of 'greenhouse gases', of which the most important is carbon dioxide. Such gases absorb infrared radiation emitted by the Earth's surface and act as blankets over the surface keeping it warmer than it would otherwise be. Associated with this warming are changes of climate. The basic science of the 'greenhouse effect' that leads to the warming is well understood. More detailed understanding relies on numerical models of the climate that integrate the basic dynamical and physical equations describing the complete climate system. Many of the likely characteristics of the resulting changes in climate (such as more frequent heat waves, increases in rainfall, increase in frequency and intensity of many extreme climate events) can be identified. Substantial uncertainties remain in knowledge of some of the feedbacks within the climate system (that affect the overall magnitude of change) and in much of the detail of likely regional change. Because of its negative impacts on human communities (including for instance substantial sea-level rise) and on ecosystems, global warming is the most important environmental problem the world faces. Adaptation to the inevitable impacts and mitigation to reduce their magnitude are both necessary. International action is being taken by the world's scientific and political communities. Because of the need for urgent action, the greatest challenge is to move rapidly to much increased energy efficiency and to non-fossil-fuel energy sources.

  7. Global Education: From Thought to Action. The 1991 ASCD Yearbook.

    ERIC Educational Resources Information Center

    Tye, Kenneth A., Ed.

    Viewed as a social movement for change, the global education movement calls for the infusion of a global perspective into all curriculum areas. Two assumptions of global education include the view of the individual school as the optimal unit for change efforts, and the importance of local teacher and school action for lasting school improvement.…

  8. Prospective Optimization

    PubMed Central

    Sejnowski, Terrence J.; Poizner, Howard; Lynch, Gary; Gepshtein, Sergei; Greenspan, Ralph J.

    2014-01-01

    Human performance approaches that of an ideal observer and optimal actor in some perceptual and motor tasks. These optimal abilities depend on the capacity of the cerebral cortex to store an immense amount of information and to flexibly make rapid decisions. However, behavior only approaches these limits after a long period of learning while the cerebral cortex interacts with the basal ganglia, an ancient part of the vertebrate brain that is responsible for learning sequences of actions directed toward achieving goals. Progress has been made in understanding the algorithms used by the brain during reinforcement learning, which is an online approximation of dynamic programming. Humans also make plans that depend on past experience by simulating different scenarios, which is called prospective optimization. The same brain structures in the cortex and basal ganglia that are active online during optimal behavior are also active offline during prospective optimization. The emergence of general principles and algorithms for goal-directed behavior has consequences for the development of autonomous devices in engineering applications. PMID:25328167

  9. [Global risk management].

    PubMed

    Sghaier, W; Hergon, E; Desroches, A

    2015-08-01

    Risk management is a fundamental component of any successful company, whether it is in economic, societal or environmental aspect. Risk management is an especially important activity for companies that optimal security challenge of products and services is great. This is the case especially for the health sector institutions. Risk management is therefore a decision support tool and a means to ensure the sustainability of an organization. In this context, what methods and approaches implemented to manage the risks? Through this state of the art, we are interested in the concept of risk and risk management processes. Then we focus on the different methods of risk management and the criteria for choosing among these methods. Finally we highlight the need to supplement these methods by a systemic and global approach including through risk assessment by the audits. PMID:26119049

  10. Optimal Fluoridation

    PubMed Central

    Lee, John R.

    1975-01-01

    Optimal fluoridation has been defined as that fluoride exposure which confers maximal cariostasis with minimal toxicity and its values have been previously determined to be 0.5 to 1 mg per day for infants and 1 to 1.5 mg per day for an average child. Total fluoride ingestion and urine excretion were studied in Marin County, California, children in 1973 before municipal water fluoridation. Results showed fluoride exposure to be higher than anticipated and fulfilled previously accepted criteria for optimal fluoridation. Present and future water fluoridation plans need to be reevaluated in light of total environmental fluoride exposure. PMID:1130041

  11. Global trends

    NASA Technical Reports Server (NTRS)

    Megie, G.; Chanin, M.-L.; Ehhalt, D.; Fraser, P.; Frederick, J. F.; Gille, J. C.; Mccormick, M. P.; Schoebert, M.; Bishop, L.; Bojkov, R. D.

    1990-01-01

    Measuring trends in ozone, and most other geophysical variables, requires that a small systematic change with time be determined from signals that have large periodic and aperiodic variations. Their time scales range from the day-to-day changes due to atmospheric motions through seasonal and annual variations to 11 year cycles resulting from changes in the sun UV output. Because of the magnitude of all of these variations is not well known and highly variable, it is necessary to measure over more than one period of the variations to remove their effects. This means that at least 2 or more times the 11 year sunspot cycle. Thus, the first requirement is for a long term data record. The second related requirement is that the record be consistent. A third requirement is for reasonable global sampling, to ensure that the effects are representative of the entire Earth. The various observational methods relevant to trend detection are reviewed to characterize their quality and time and space coverage. Available data are then examined for long term trends or recent changes in ozone total content and vertical distribution, as well as related parameters such as stratospheric temperature, source gases and aerosols.

  12. Coupled Low-thrust Trajectory and System Optimization via Multi-Objective Hybrid Optimal Control

    NASA Technical Reports Server (NTRS)

    Vavrina, Matthew A.; Englander, Jacob Aldo; Ghosh, Alexander R.

    2015-01-01

    The optimization of low-thrust trajectories is tightly coupled with the spacecraft hardware. Trading trajectory characteristics with system parameters ton identify viable solutions and determine mission sensitivities across discrete hardware configurations is labor intensive. Local independent optimization runs can sample the design space, but a global exploration that resolves the relationships between the system variables across multiple objectives enables a full mapping of the optimal solution space. A multi-objective, hybrid optimal control algorithm is formulated using a multi-objective genetic algorithm as an outer loop systems optimizer around a global trajectory optimizer. The coupled problem is solved simultaneously to generate Pareto-optimal solutions in a single execution. The automated approach is demonstrated on two boulder return missions.

  13. Optimization Methods in Sherpa

    NASA Astrophysics Data System (ADS)

    Siemiginowska, Aneta; Nguyen, Dan T.; Doe, Stephen M.; Refsdal, Brian L.

    2009-09-01

    Forward fitting is a standard technique used to model X-ray data. A statistic, usually assumed weighted chi^2 or Poisson likelihood (e.g. Cash), is minimized in the fitting process to obtain a set of the best model parameters. Astronomical models often have complex forms with many parameters that can be correlated (e.g. an absorbed power law). Minimization is not trivial in such setting, as the statistical parameter space becomes multimodal and finding the global minimum is hard. Standard minimization algorithms can be found in many libraries of scientific functions, but they are usually focused on specific functions. However, Sherpa designed as general fitting and modeling application requires very robust optimization methods that can be applied to variety of astronomical data (X-ray spectra, images, timing, optical data etc.). We developed several optimization algorithms in Sherpa targeting a wide range of minimization problems. Two local minimization methods were built: Levenberg-Marquardt algorithm was obtained from MINPACK subroutine LMDIF and modified to achieve the required robustness; and Nelder-Mead simplex method has been implemented in-house based on variations of the algorithm described in the literature. A global search Monte-Carlo method has been implemented following a differential evolution algorithm presented by Storn and Price (1997). We will present the methods in Sherpa and discuss their usage cases. We will focus on the application to Chandra data showing both 1D and 2D examples. This work is supported by NASA contract NAS8-03060 (CXC).

  14. Gear optimization

    NASA Technical Reports Server (NTRS)

    Vanderplaats, G. N.; Chen, Xiang; Zhang, Ning-Tian

    1988-01-01

    The use of formal numerical optimization methods for the design of gears is investigated. To achieve this, computer codes were developed for the analysis of spur gears and spiral bevel gears. These codes calculate the life, dynamic load, bending strength, surface durability, gear weight and size, and various geometric parameters. It is necessary to calculate all such important responses because they all represent competing requirements in the design process. The codes developed here were written in subroutine form and coupled to the COPES/ADS general purpose optimization program. This code allows the user to define the optimization problem at the time of program execution. Typical design variables include face width, number of teeth and diametral pitch. The user is free to choose any calculated response as the design objective to minimize or maximize and may impose lower and upper bounds on any calculated responses. Typical examples include life maximization with limits on dynamic load, stress, weight, etc. or minimization of weight subject to limits on life, dynamic load, etc. The research codes were written in modular form for easy expansion and so that they could be combined to create a multiple reduction optimization capability in future.

  15. Multilevel algorithms for nonlinear optimization

    NASA Technical Reports Server (NTRS)

    Alexandrov, Natalia; Dennis, J. E., Jr.

    1994-01-01

    Multidisciplinary design optimization (MDO) gives rise to nonlinear optimization problems characterized by a large number of constraints that naturally occur in blocks. We propose a class of multilevel optimization methods motivated by the structure and number of constraints and by the expense of the derivative computations for MDO. The algorithms are an extension to the nonlinear programming problem of the successful class of local Brown-Brent algorithms for nonlinear equations. Our extensions allow the user to partition constraints into arbitrary blocks to fit the application, and they separately process each block and the objective function, restricted to certain subspaces. The methods use trust regions as a globalization strategy, and they have been shown to be globally convergent under reasonable assumptions. The multilevel algorithms can be applied to all classes of MDO formulations. Multilevel algorithms for solving nonlinear systems of equations are a special case of the multilevel optimization methods. In this case, they can be viewed as a trust-region globalization of the Brown-Brent class.

  16. [Characteristics of seasonal drought and its adaptation in southern China under the background of global climate change. VI. Optimized layout of cropping system for preventing and avoiding drought disaster].

    PubMed

    Sui, Yue; Huang, Wan-Hua; Yang, Xiao-Guang; Li, Mao-Song

    2013-11-01

    Southern China is an important agricultural planting region of China, but the seasonal drought severely impacted the regional agricultural production. Based on the 1981-2007 meteorological data from 13 typical meteorological stations in the seasonal drought areas in southern China and the data of related crops growth period and yield, three precipitation year types (drought year, normal year, and wet year) were classified based on the yearly precipitation, and by using five indices (coupling degree of water requirement and precipitation during crop water critical stages, meteorological crop yield, output value per unit area, and water use efficiency and precipitation during whole growth period), the comprehensive benefit of all possible cropping patterns in each typical region was evaluated, and the optimal cropping patterns in the different regions of southern China in different precipitation years were obtained. In the semi-arid region, the optimal cropping patterns in dry year included potato-maize-sweet potato and winter wheat-rice-sweet potato. In the semi-humid region and during dry year, winter wheat-rice-sweet potato was the best choice, and rape seed-rice-sweet potato was the second one. In the warm and humid region (the typical region where seasonal drought happened), the best cropping pattern in Jiangnan area in different precipitation years was potato-double cropping rice, and the suitable patterns in southwest area were the triple cropping systems with drought-resistant crops, such as winter wheat-rice-sweet potato, winter wheat-maize-sweet potato, and potato-double cropping rice. From the aspect of maximally utilizing water and heat resources, triple cropping would be the best choice, with the rice and upland crop rotation as the main and with the rice arranged in pairs in wet year. PMID:24564149

  17. Design optimization of transonic airfoils

    NASA Technical Reports Server (NTRS)

    Joh, C.-Y.; Grossman, B.; Haftka, R. T.

    1991-01-01

    Numerical optimization procedures were considered for the design of airfoils in transonic flow based on the transonic small disturbance (TSD) and Euler equations. A sequential approximation optimization technique was implemented with an accurate approximation of the wave drag based on the Nixon's coordinate straining approach. A modification of the Euler surface boundary conditions was implemented in order to efficiently compute design sensitivities without remeshing the grid. Two effective design procedures producing converged designs in approximately 10 global iterations were developed: interchanging the role of the objective function and constraint and the direct lift maximization with move limits which were fixed absolute values of the design variables.

  18. THE IMPACTS OF GLOBAL INFRASTRUCTURE UPON GLOBAL PRODUCTION-TRADE STRUCTURE

    NASA Astrophysics Data System (ADS)

    Xu, Daming; Kobayashi, Kiyoshi; Matsushima, Kakuya

    In this paper, a two countries model is formulated to investigate the global production-trade patters emerged by the location behaviors of multi-national enterprises. Two countries are characterized by heterogeneous labor productivities. The multi-national enterprises, heterogeneous in productivities, are supposed to provide the differentiated commodities in the monopolistically competitive global market. The enterprises purchase differentiated knowledge at the fixed cost from the international research organization. They determine production locations in the global economy. The comparative static analysis is carried out to investigate the impacts of global infrastructure arrangement, associated with the decrease of transportation costs, upon the optimal production-trade patterns in the economy.

  19. Multiobjective Optimization Using a Pareto Differential Evolution Approach

    NASA Technical Reports Server (NTRS)

    Madavan, Nateri K.; Biegel, Bryan A. (Technical Monitor)

    2002-01-01

    Differential Evolution is a simple, fast, and robust evolutionary algorithm that has proven effective in determining the global optimum for several difficult single-objective optimization problems. In this paper, the Differential Evolution algorithm is extended to multiobjective optimization problems by using a Pareto-based approach. The algorithm performs well when applied to several test optimization problems from the literature.

  20. Ethical Issues in Pediatric Global Health.

    PubMed

    Adams, Lisa; Suresh, Gautham K; Lahey, Tim

    2016-02-01

    Children are vulnerable to the priorities and decision-making of adults. Usually, parents/caregivers make the difficult healthcare decisions for their children based on the recommendations from the child's healthcare providers. In global health work, healthcare team members from different countries and cultures may guide healthcare decisions by parents and children, and as a result ethical assumptions may not be shared. As a result, ethical issues in pediatric global health are numerous and complex. Here we discuss critical ethical issues in global health at an individual and organizational level in hopes this supports optimized decision-making on behalf of children worldwide. PMID:26613697

  1. Neutralizer optimization

    NASA Technical Reports Server (NTRS)

    Patterson, Michael J.; Mohajeri, Kayhan

    1991-01-01

    The preliminary results of a test program to optimize a neutralizer design for 30 cm xenon ion thrusters are discussed. The impact of neutralizer geometry, neutralizer axial location, and local magnetic fields on neutralizer performance is discussed. The effect of neutralizer performance on overall thruster performance is quantified, for thruster operation in the 0.5-3.2 kW power range. Additionally, these data are compared to data published for other north-south stationkeeping (NSSK) and primary propulsion xenon ion thruster neutralizers.

  2. An Attainable Global Perspective.

    ERIC Educational Resources Information Center

    de Castaneda, Viann Pedersen

    Concordia College (Minnesota) has established a global studies curriculum that encourages the development of a global perspective in future business leaders. Global perspective is seen as having five dimensions: (1) perspective consciousness; (2) "state of the planet" awareness; (3) cross-cultural awareness; (4) knowledge of global dynamics; and…

  3. [SIAM conference on optimization

    SciTech Connect

    Not Available

    1992-05-10

    Abstracts are presented of 63 papers on the following topics: large-scale optimization, interior-point methods, algorithms for optimization, problems in control, network optimization methods, and parallel algorithms for optimization problems.

  4. Protein structure optimization with a "Lamarckian" ant colony algorithm.

    PubMed

    Oakley, Mark T; Richardson, E Grace; Carr, Harriet; Johnston, Roy L

    2013-01-01

    We describe the LamarckiAnt algorithm: a search algorithm that combines the features of a "Lamarckian" genetic algorithm and ant colony optimization. We have implemented this algorithm for the optimization of BLN model proteins, which have frustrated energy landscapes and represent a challenge for global optimization algorithms. We demonstrate that LamarckiAnt performs competitively with other state-of-the-art optimization algorithms. PMID:24407312

  5. An overview of the optimization modelling applications

    NASA Astrophysics Data System (ADS)

    Singh, Ajay

    2012-10-01

    SummaryThe optimal use of available resources is of paramount importance in the backdrop of the increasing food, fiber, and other demands of the burgeoning global population and the shrinking resources. The optimal use of these resources can be determined by employing an optimization technique. The comprehensive reviews on the use of various programming techniques for the solution of different optimization problems have been provided in this paper. The past reviews are grouped into nine sections based on the solutions of the theme-based real world problems. The sections include: use of optimization modelling for conjunctive use planning, groundwater management, seawater intrusion management, irrigation management, achieving optimal cropping pattern, management of reservoir systems operation, management of resources in arid and semi-arid regions, solid waste management, and miscellaneous uses which comprise, managing problems of hydropower generation and sugar industry. Conclusions are drawn where gaps exist and more research needs to be focused.

  6. Tractable Pareto Optimization of Temporal Preferences

    NASA Technical Reports Server (NTRS)

    Morris, Robert; Morris, Paul; Khatib, Lina; Venable, Brent

    2003-01-01

    This paper focuses on temporal constraint problems where the objective is to optimize a set of local preferences for when events occur. In previous work, a subclass of these problems has been formalized as a generalization of Temporal CSPs, and a tractable strategy for optimization has been proposed, where global optimality is defined as maximizing the minimum of the component preference values. This criterion for optimality, which we call 'Weakest Link Optimization' (WLO), is known to have limited practical usefulness because solutions are compared only on the basis of their worst value; thus, there is no requirement to improve the other values. To address this limitation, we introduce a new algorithm that re-applies WLO iteratively in a way that leads to improvement of all the values. We show the value of this strategy by proving that, with suitable preference functions, the resulting solutions are Pareto Optimal.

  7. Adaptation and optimization of biological transport networks.

    PubMed

    Hu, Dan; Cai, David

    2013-09-27

    It has been hypothesized that topological structures of biological transport networks are consequences of energy optimization. Motivated by experimental observation, we propose that adaptation dynamics may underlie this optimization. In contrast to the global nature of optimization, our adaptation dynamics responds only to local information and can naturally incorporate fluctuations in flow distributions. The adaptation dynamics minimizes the global energy consumption to produce optimal networks, which may possess hierarchical loop structures in the presence of strong fluctuations in flow distribution. We further show that there may exist a new phase transition as there is a critical open probability of sinks, above which there are only trees for network structures whereas below which loops begin to emerge. PMID:24116821

  8. Optimal Network Modularity for Information Diffusion

    NASA Astrophysics Data System (ADS)

    Nematzadeh, Azadeh; Ferrara, Emilio; Flammini, Alessandro; Ahn, Yong-Yeol

    2014-08-01

    We investigate the impact of community structure on information diffusion with the linear threshold model. Our results demonstrate that modular structure may have counterintuitive effects on information diffusion when social reinforcement is present. We show that strong communities can facilitate global diffusion by enhancing local, intracommunity spreading. Using both analytic approaches and numerical simulations, we demonstrate the existence of an optimal network modularity, where global diffusion requires the minimal number of early adopters.

  9. Adaptive Cuckoo Search Algorithm for Unconstrained Optimization

    PubMed Central

    2014-01-01

    Modification of the intensification and diversification approaches in the recently developed cuckoo search algorithm (CSA) is performed. The alteration involves the implementation of adaptive step size adjustment strategy, and thus enabling faster convergence to the global optimal solutions. The feasibility of the proposed algorithm is validated against benchmark optimization functions, where the obtained results demonstrate a marked improvement over the standard CSA, in all the cases. PMID:25298971

  10. Semiclassical guided optimal control of molecular dynamics

    SciTech Connect

    Kondorskiy, A.; Mil'nikov, G.; Nakamura, H.

    2005-10-15

    An efficient semiclassical optimal control theory applicable to multidimensional systems is formulated for controlling wave packet dynamics on a single adiabatic potential energy surface. The approach combines advantages of different formulations of optimal control theory: quantum and classical on one hand and global and local on the other. Numerical applications to the control of HCN-CNH isomerization demonstrate that this theory can provide an efficient tool to manipulate molecular dynamics of many degrees of freedom by laser pulses.

  11. Adaptive cuckoo search algorithm for unconstrained optimization.

    PubMed

    Ong, Pauline

    2014-01-01

    Modification of the intensification and diversification approaches in the recently developed cuckoo search algorithm (CSA) is performed. The alteration involves the implementation of adaptive step size adjustment strategy, and thus enabling faster convergence to the global optimal solutions. The feasibility of the proposed algorithm is validated against benchmark optimization functions, where the obtained results demonstrate a marked improvement over the standard CSA, in all the cases. PMID:25298971

  12. Transforming Academic Globalization into Globalization for All

    ERIC Educational Resources Information Center

    Ramalhoto, M. F.

    2006-01-01

    Driving innovation and continuous improvement with regard to ecological, environmental and human sustainability is essential for win-win globalization. That calls for research on strategic and monitoring planning to manage globalization and technological and scientific change. This paper describes a new basic function of the university institution…

  13. Optimal refrigerator

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Hovhannisyan, Karen; Mahler, Guenter

    2010-05-01

    We study a refrigerator model which consists of two n -level systems interacting via a pulsed external field. Each system couples to its own thermal bath at temperatures Th and Tc , respectively (θ≡Tc/Th<1) . The refrigerator functions in two steps: thermally isolated interaction between the systems driven by the external field and isothermal relaxation back to equilibrium. There is a complementarity between the power of heat transfer from the cold bath and the efficiency: the latter nullifies when the former is maximized and vice versa. A reasonable compromise is achieved by optimizing the product of the heat-power and efficiency over the Hamiltonian of the two systems. The efficiency is then found to be bounded from below by ζCA=(1)/(1-θ)-1 (an analog of the Curzon-Ahlborn efficiency), besides being bound from above by the Carnot efficiency ζC=(1)/(1-θ)-1 . The lower bound is reached in the equilibrium limit θ→1 . The Carnot bound is reached (for a finite power and a finite amount of heat transferred per cycle) for lnn≫1 . If the above maximization is constrained by assuming homogeneous energy spectra for both systems, the efficiency is bounded from above by ζCA and converges to it for n≫1 .

  14. Optimal refrigerator.

    PubMed

    Allahverdyan, Armen E; Hovhannisyan, Karen; Mahler, Guenter

    2010-05-01

    We study a refrigerator model which consists of two n -level systems interacting via a pulsed external field. Each system couples to its own thermal bath at temperatures T h and T c, respectively (θ ≡ T c/T h < 1). The refrigerator functions in two steps: thermally isolated interaction between the systems driven by the external field and isothermal relaxation back to equilibrium. There is a complementarity between the power of heat transfer from the cold bath and the efficiency: the latter nullifies when the former is maximized and vice versa. A reasonable compromise is achieved by optimizing the product of the heat-power and efficiency over the Hamiltonian of the two systems. The efficiency is then found to be bounded from below by [formula: see text] (an analog of the Curzon-Ahlborn efficiency), besides being bound from above by the Carnot efficiency [formula: see text]. The lower bound is reached in the equilibrium limit θ → 1. The Carnot bound is reached (for a finite power and a finite amount of heat transferred per cycle) for ln n > 1. If the above maximization is constrained by assuming homogeneous energy spectra for both systems, the efficiency is bounded from above by ζ CA and converges to it for n > 1. PMID:20866207

  15. Essential Web Sites to Research the Globalization Process

    ERIC Educational Resources Information Center

    Scott, Thomas J.; O'Sullivan, Michael

    2002-01-01

    The terrorist attacks of September 11, 2001, brought a stark reality to social studies classrooms throughout the United States. Globalism and the expansion of world trade relations created optimism about enhanced cultural understanding, peace, and economic prosperity. However, it is clear that globalization also has a dark side. Suddenly…

  16. Global health and neonatal nursing: a personal journey.

    PubMed

    Kenner, Carole; Boykova, Marina

    2012-09-01

    The need for improvement of neonatal nursing care is a global issue. Neonatal nurses have an important role in optimizing these health outcomes for neonates and their families. This article describes the personal journey of one nurse and her mentee. It describes how a passion for neonates led to global policy work. PMID:22895204

  17. Trajectory optimization for the National Aerospace Plane

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1993-01-01

    The objective of this second phase research is to investigate the optimal ascent trajectory for the National Aerospace Plane (NASP) from runway take-off to orbital insertion and address the unique problems associated with the hypersonic flight trajectory optimization. The trajectory optimization problem for an aerospace plane is a highly challenging problem because of the complexity involved. Previous work has been successful in obtaining sub-optimal trajectories by using energy-state approximation and time-scale decomposition techniques. But it is known that the energy-state approximation is not valid in certain portions of the trajectory. This research aims at employing full dynamics of the aerospace plane and emphasizing direct trajectory optimization methods. The major accomplishments of this research include the first-time development of an inverse dynamics approach in trajectory optimization which enables us to generate optimal trajectories for the aerospace plane efficiently and reliably, and general analytical solutions to constrained hypersonic trajectories that has wide application in trajectory optimization as well as in guidance and flight dynamics. Optimal trajectories in abort landing and ascent augmented with rocket propulsion and thrust vectoring control were also investigated. Motivated by this study, a new global trajectory optimization tool using continuous simulated annealing and a nonlinear predictive feedback guidance law have been under investigation and some promising results have been obtained, which may well lead to more significant development and application in the near future.

  18. Global Tuberculosis Report 2015

    MedlinePlus

    ... Feed Youtube Twitter Facebook Google + iTunes Play Store Tuberculosis (TB) Menu Tuberculosis The End TB Strategy Areas ... data News, events and features About us Global tuberculosis report 2015 This is the twentieth global report ...

  19. Global Health Observatory (GHO)

    MedlinePlus

    ... repository Reports Country statistics Map gallery Standards Global Health Observatory (GHO) data Monitoring health for the SDGs ... relevant web pages on the theme. Monitoring the health goal: indicators of overall progress Mortality and global ...

  20. IMERG Global Precipitation Rates

    NASA Video Gallery

    NASA's Global Precipitation Measurement mission has produced its first global map of rainfall and snowfall. The GPM Core Observatory launched one year ago on Feb. 27, 2014 as a collaboration betwee...

  1. Global Atmospheric Aerosol Modeling

    NASA Technical Reports Server (NTRS)

    Hendricks, Johannes; Aquila, Valentina; Righi, Mattia

    2012-01-01

    Global aerosol models are used to study the distribution and properties of atmospheric aerosol particles as well as their effects on clouds, atmospheric chemistry, radiation, and climate. The present article provides an overview of the basic concepts of global atmospheric aerosol modeling and shows some examples from a global aerosol simulation. Particular emphasis is placed on the simulation of aerosol particles and their effects within global climate models.

  2. The Psychology of Globalization.

    ERIC Educational Resources Information Center

    Arnett, Jeffrey Jensen

    2002-01-01

    Examines the influence of globalization on psychological functioning, describing globalization worldwide and its psychological consequences. Notes that most people now develop bicultural identities that combine local identity with global culture-related identity. Identity confusion is increasing among young people in non-western cultures because…

  3. Developing Successful Global Leaders

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    Everyone seems to agree the world desperately needs strong leaders who can manage a global workforce and all the inherent challenges that go with it. That's a big part of the raison d'etre for global leadership development programs. But are today's organizations fully utilizing these programs to develop global leaders, and, if so, are they…

  4. Mapping Global Citizenship

    ERIC Educational Resources Information Center

    Stein, Sharon

    2015-01-01

    The demand to cultivate global citizenship is frequently invoked as central to colleges' and universities' internationalization efforts. However, the term "global citizenship" remains undertheorized in the context of U.S. higher education. This article maps and engages three common global citizenship positions--entrepreneurial, liberal…

  5. Globalization and American Education

    ERIC Educational Resources Information Center

    Merriman, William; Nicoletti, Augustine

    2008-01-01

    Globalization is a potent force in today's world. The welfare of the United States is tied to the welfare of other countries by economics, the environment, politics, culture, information, and technology. This paper identifies the implications of globalization for education, presents applications of important aspects of globalization that teachers…

  6. The Microsoft Global Ortho Program

    NASA Astrophysics Data System (ADS)

    Walcher, W.; Leberl, F.; Gruber, M.

    2012-07-01

    Wide area and thus continental mapping extending beyond national borders is a novel concept in civilian photogrammetry. The Microsoft Global Ortho Program was launched in the Spring of 2009 as a result of Microsoft's need for global geo-data at a high geometric resolution and radiometric excellence. By fall of 2012 more than 10 million km2 of the USA and 14 European countries will have been covered by seamless 30 cm GSD color-, 60 cm GSD false-color infrared ortho-mosaics and a 1 meter GSD digital surface model. The ortho-maps are being published to Microsoft's Bing Maps Internet mapping portal. The Global Ortho Program was designed for highly and unprecedented automated mapping of essentially entire continents. In 2011, exclusive of flight operations, the product output per person has been measured in excess of 275,000 square km per year. We describe research efforts that made this achievement possible. Those include a specially designed aerial sensor (Ultracam G), logistics simulation for fight planning and optimization, in-flight blur detection and subsequent automatic blur removal, modeling and removal of atmospheric and environmental conditions, automated shear detection and DTM refinement, an IT architecture to process >200,000 aerial images/day, and for creating over 1,000,000 km2 ortho-imagery and DSM data in 24 hours. While addressing these issues, we provide ideas how this might affect the future of spatial infrastructure initiatives.

  7. Global temperatures and the global warming ``debate''

    NASA Astrophysics Data System (ADS)

    Aubrecht, Gordon

    2009-04-01

    Many ordinary citizens listen to pronouncements on talk radio casting doubt on anthropogenic global warming. Some op-ed columnists likewise cast doubts, and are read by credulous citizens. For example, on 8 March 2009, the Boston Globe published a column by Jeff Jacoby, ``Where's global warming?'' According to Jacoby, ``But it isn't such hints of a planetary warming trend that have been piling up in profusion lately. Just the opposite.'' He goes on to write, ``the science of climate change is not nearly as important as the religion of climate change,'' and blamed Al Gore for getting his mistaken views accepted. George Will at the Washington Post also expressed denial. As a result, 44% of U.S. voters, according to the January 19 2009 Rasmussen Report, blame long-term planetary trends for global warming, not human beings. Is there global cooling, as skeptics claim? We examine the temperature record.

  8. Global sea level linked to global temperature

    PubMed Central

    Vermeer, Martin; Rahmstorf, Stefan

    2009-01-01

    We propose a simple relationship linking global sea-level variations on time scales of decades to centuries to global mean temperature. This relationship is tested on synthetic data from a global climate model for the past millennium and the next century. When applied to observed data of sea level and temperature for 1880–2000, and taking into account known anthropogenic hydrologic contributions to sea level, the correlation is >0.99, explaining 98% of the variance. For future global temperature scenarios of the Intergovernmental Panel on Climate Change's Fourth Assessment Report, the relationship projects a sea-level rise ranging from 75 to 190 cm for the period 1990–2100. PMID:19995972

  9. Global Health and the Global Economic Crisis

    PubMed Central

    Gill, Stephen; Bakker, Isabella

    2011-01-01

    Although the resources and knowledge for achieving improved global health exist, a new, critical paradigm on health as an aspect of human development, human security, and human rights is needed. Such a shift is required to sufficiently modify and credibly reduce the present dominance of perverse market forces on global health. New scientific discoveries can make wide-ranging contributions to improved health; however, improved global health depends on achieving greater social justice, economic redistribution, and enhanced democratization of production, caring social institutions for essential health care, education, and other public goods. As with the quest for an HIV vaccine, the challenge of improved global health requires an ambitious multidisciplinary research program. PMID:21330597

  10. Global social identity and global cooperation.

    PubMed

    Buchan, Nancy R; Brewer, Marilynn B; Grimalda, Gianluca; Wilson, Rick K; Fatas, Enrique; Foddy, Margaret

    2011-06-01

    This research examined the question of whether the psychology of social identity can motivate cooperation in the context of a global collective. Our data came from a multinational study of choice behavior in a multilevel public-goods dilemma conducted among samples drawn from the general populations of the United States, Italy, Russia, Argentina, South Africa, and Iran. Results demonstrate that an inclusive social identification with the world community is a meaningful psychological construct that plays a role in motivating cooperation that transcends parochial interests. Self-reported identification with the world as a whole predicts behavioral contributions to a global public good beyond what is predicted from expectations about what other people are likely to contribute. Furthermore, global social identification is conceptually distinct from general attitudes about global issues, and has unique effects on cooperative behavior. PMID:21586763

  11. Synergy optimization and operation management on syndicate complementary knowledge cooperation

    NASA Astrophysics Data System (ADS)

    Tu, Kai-Jan

    2014-10-01

    The number of multi enterprises knowledge cooperation has grown steadily, as a result of global innovation competitions. I have conducted research based on optimization and operation studies in this article, and gained the conclusion that synergy management is effective means to break through various management barriers and solve cooperation's chaotic systems. Enterprises must communicate system vision and access complementary knowledge. These are crucial considerations for enterprises to exert their optimization and operation knowledge cooperation synergy to meet global marketing challenges.

  12. Beyond global warming: Ecology and global change

    SciTech Connect

    Vitousek, P.M. )

    1994-10-01

    While ecologists involved in management or policy often are advised to learn to deal with uncertainty, some components of global environmental change are certainly occurring and are certainly human-caused. All have important ecological consequences. Well-documented global changes include: Increasing concentrations of carbon dioxide in the atmosphere; alterations in the biogeochemistry of the global nitrogen cycle; and ongoing land use/land cover change. Human activity - now primarily fossil fuel combustion - has increased carbon dioxide concentrations from [approximately] 280 to 355 [mu]L/L since 1800 and is likely to have climatic consequences and direct effects on biota in all terrestrial ecosystems. The global nitrogen cycle has been altered so that more nitrogen is fixed annually by humanity than by all natural pathways combined. Altering atmospheric chemistry and aquatic ecosystems, contributes to eutrophication of the biosphere, and has substantial regional effects on biological diversity. Finally, human land use/land cover change has transformed one-third to one-half of Earth's ice-free surface, representing the most important component of global change now. Any clear dichotomy between pristine ecosystems and human-altered areas that may have existed in the past has vanished, and ecological research should account for this reality. Certain components of global environmental change are the primary causes of anticipated changes in climate, and of ongoing losses of biological diversity. They are caused by the extraordinary growth in size and resource use of the human population. On a broad scale, there is little uncertainty about any of these components of change or their causes. However, much of the public believes the causes of global change to be uncertain and contentious. By speaking out effectively,the focus of public discussion towards what can and should be done about global environmental change can be shifted. 135 refs., 13 figs., 1 tab.

  13. Global perspectives: A new global ethic, a new global partnership

    SciTech Connect

    Brundtland, G.H.

    1990-06-01

    In her keynote address at the opening plenary session of the Globe '90 Conference held in Vancouver in March, Mrs. Brundtland called for a new global partnership of government, industry, producers and consumers to meet present and future environmental challenges. This partnership would require help to developing countries to help free them from their handicaps of debt, overpopulation and poverty; that improvements made to the environment would not be offset by ecological damage in other areas. She was encouraged that the policy of sustainable development has been widely adapted as the only viable strategy for global change.

  14. Composite Particle Swarm Optimizer With Historical Memory for Function Optimization.

    PubMed

    Li, Jie; Zhang, JunQi; Jiang, ChangJun; Zhou, MengChu

    2015-10-01

    Particle swarm optimization (PSO) algorithm is a population-based stochastic optimization technique. It is characterized by the collaborative search in which each particle is attracted toward the global best position (gbest) in the swarm and its own best position (pbest). However, all of particles' historical promising pbests in PSO are lost except their current pbests. In order to solve this problem, this paper proposes a novel composite PSO algorithm, called historical memory-based PSO (HMPSO), which uses an estimation of distribution algorithm to estimate and preserve the distribution information of particles' historical promising pbests. Each particle has three candidate positions, which are generated from the historical memory, particles' current pbests, and the swarm's gbest. Then the best candidate position is adopted. Experiments on 28 CEC2013 benchmark functions demonstrate the superiority of HMPSO over other algorithms. PMID:26390177

  15. MOGO: Model-Oriented Global Optimization of Petascale Applications

    SciTech Connect

    Malony, Allen D.; Shende, Sameer S.

    2012-09-14

    The MOGO project was initiated under in 2008 under the DOE Program Announcement for Software Development Tools for Improved Ease-of-Use on Petascale systems (LAB 08-19). The MOGO team consisted of Oak Ridge National Lab, Argonne National Lab, and the University of Oregon. The overall goal of MOGO was to attack petascale performance analysis by developing a general framework where empirical performance data could be efficiently and accurately compared with performance expectations at various levels of abstraction. This information could then be used to automatically identify and remediate performance problems. MOGO was be based on performance models derived from application knowledge, performance experiments, and symbolic analysis. MOGO was able to make reasonable impact on existing DOE applications and systems. New tools and techniques were developed, which, in turn, were used on important DOE applications on DOE LCF systems to show significant performance improvements.

  16. Study of a global search algorithm for optimal control.

    NASA Technical Reports Server (NTRS)

    Brocker, D. H.; Kavanaugh, W. P.; Stewart, E. C.

    1967-01-01

    Adaptive random search algorithm utilizing boundary cost-function hypersurfaces measurement to implement Pontryagin maximum principle, discussing hybrid computer use, iterative solution and convergence properties

  17. A competitive swarm optimizer for large scale optimization.

    PubMed

    Cheng, Ran; Jin, Yaochu

    2015-02-01

    In this paper, a novel competitive swarm optimizer (CSO) for large scale optimization is proposed. The algorithm is fundamentally inspired by the particle swarm optimization but is conceptually very different. In the proposed CSO, neither the personal best position of each particle nor the global best position (or neighborhood best positions) is involved in updating the particles. Instead, a pairwise competition mechanism is introduced, where the particle that loses the competition will update its position by learning from the winner. To understand the search behavior of the proposed CSO, a theoretical proof of convergence is provided, together with empirical analysis of its exploration and exploitation abilities showing that the proposed CSO achieves a good balance between exploration and exploitation. Despite its algorithmic simplicity, our empirical results demonstrate that the proposed CSO exhibits a better overall performance than five state-of-the-art metaheuristic algorithms on a set of widely used large scale optimization problems and is able to effectively solve problems of dimensionality up to 5000. PMID:24860047

  18. Global Collaborative STEM Education

    NASA Astrophysics Data System (ADS)

    Meabh Kelly, Susan; Smith, Walter

    2016-04-01

    Global Collaborative STEM Education, as the name suggests, simultaneously supports two sets of knowledge and skills. The first set is STEM -- science, technology, engineering and math. The other set of content knowledge and skills is that of global collaboration. Successful global partnerships require awareness of one's own culture, the biases embedded within that culture, as well as developing awareness of the collaborators' culture. Workforce skills fostered include open-mindedness, perseverance when faced with obstacles, and resourceful use of technological "bridges" to facilitate and sustain communication. In respect for the 2016 GIFT Workshop focus, Global Collaborative STEM Education projects dedicated to astronomy research will be presented. The projects represent different benchmarks within the Global Collaborative STEM Education continuum, culminating in an astronomy research experience that fully reflects how the global STEM workforce collaborates. To facilitate wider engagement in Global Collaborative STEM Education, project summaries, classroom resources and contact information for established international collaborative astronomy research projects will be disseminated.

  19. The genetic algorithms for trajectory optimization

    NASA Astrophysics Data System (ADS)

    Janin, G.; Gomez-Tierno, M. A.

    1985-10-01

    Possible difficulties encountered when solving space flight trajectory optimization problems are recalled. The need of a global optimization scheme is realized. Nondeterministic methods, called here stochastic methods, seem to be good candidates for solving these types of problems. A particular class of such methods, modelled upon search strategies employed in natural adaptation, is proposed here: the genetic algorithms. Two models, the mutation-selection and the crossover-selection, are discussed and remarks resulting from applications to test problems and space flight problems are made. It is concluded that a considerable effort is still needed for developing efficient schemes using genetic algorithms. However, they appear to offer an entirely original way for solving a large class of global optimization problems and they are particularly well-suited for parallel processing to be used in the fifth generation computers.

  20. Improvement of characteristic statistic algorithm and its application on equilibrium cycle reloading optimization

    SciTech Connect

    Hu, Y.; Liu, Z.; Shi, X.; Wang, B.

    2006-07-01

    A brief introduction of characteristic statistic algorithm (CSA) is given in the paper, which is a new global optimization algorithm to solve the problem of PWR in-core fuel management optimization. CSA is modified by the adoption of back propagation neural network and fast local adjustment. Then the modified CSA is applied to PWR Equilibrium Cycle Reloading Optimization, and the corresponding optimization code of CSA-DYW is developed. CSA-DYW is used to optimize the equilibrium cycle of 18 month reloading of Daya bay nuclear plant Unit 1 reactor. The results show that CSA-DYW has high efficiency and good global performance on PWR Equilibrium Cycle Reloading Optimization. (authors)

  1. Singularities in Optimal Structural Design

    NASA Technical Reports Server (NTRS)

    Patnaik, S. N.; Guptill, J. D.; Berke, L.

    1992-01-01

    Singularity conditions that arise during structural optimization can seriously degrade the performance of the optimizer. The singularities are intrinsic to the formulation of the structural optimization problem and are not associated with the method of analysis. Certain conditions that give rise to singularities have been identified in earlier papers, encompassing the entire structure. Further examination revealed more complex sets of conditions in which singularities occur. Some of these singularities are local in nature, being associated with only a segment of the structure. Moreover, the likelihood that one of these local singularities may arise during an optimization procedure can be much greater than that of the global singularity identified earlier. Examples are provided of these additional forms of singularities. A framework is also given in which these singularities can be recognized. In particular, the singularities can be identified by examination of the stress displacement relations along with the compatibility conditions and/or the displacement stress relations derived in the integrated force method of structural analysis.

  2. Singularities in optimal structural design

    NASA Technical Reports Server (NTRS)

    Patnaik, S. N.; Guptill, J. D.; Berke, L.

    1992-01-01

    Singularity conditions that arise during structural optimization can seriously degrade the performance of the optimizer. The singularities are intrinsic to the formulation of the structural optimization problem and are not associated with the method of analysis. Certain conditions that give rise to singularities have been identified in earlier papers, encompassing the entire structure. Further examination revealed more complex sets of conditions in which singularities occur. Some of these singularities are local in nature, being associated with only a segment of the structure. Moreover, the likelihood that one of these local singularities may arise during an optimization procedure can be much greater than that of the global singularity identified earlier. Examples are provided of these additional forms of singularities. A framework is also given in which these singularities can be recognized. In particular, the singularities can be identified by examination of the stress displacement relations along with the compatibility conditions and/or the displacement stress relations derived in the integrated force method of structural analysis.

  3. Global warming without global mean precipitation increase?

    PubMed

    Salzmann, Marc

    2016-06-01

    Global climate models simulate a robust increase of global mean precipitation of about 1.5 to 2% per kelvin surface warming in response to greenhouse gas (GHG) forcing. Here, it is shown that the sensitivity to aerosol cooling is robust as well, albeit roughly twice as large. This larger sensitivity is consistent with energy budget arguments. At the same time, it is still considerably lower than the 6.5 to 7% K(-1) decrease of the water vapor concentration with cooling from anthropogenic aerosol because the water vapor radiative feedback lowers the hydrological sensitivity to anthropogenic forcings. When GHG and aerosol forcings are combined, the climate models with a realistic 20th century warming indicate that the global mean precipitation increase due to GHG warming has, until recently, been completely masked by aerosol drying. This explains the apparent lack of sensitivity of the global mean precipitation to the net global warming recently found in observations. As the importance of GHG warming increases in the future, a clear signal will emerge. PMID:27386558

  4. Global warming without global mean precipitation increase?

    PubMed Central

    Salzmann, Marc

    2016-01-01

    Global climate models simulate a robust increase of global mean precipitation of about 1.5 to 2% per kelvin surface warming in response to greenhouse gas (GHG) forcing. Here, it is shown that the sensitivity to aerosol cooling is robust as well, albeit roughly twice as large. This larger sensitivity is consistent with energy budget arguments. At the same time, it is still considerably lower than the 6.5 to 7% K−1 decrease of the water vapor concentration with cooling from anthropogenic aerosol because the water vapor radiative feedback lowers the hydrological sensitivity to anthropogenic forcings. When GHG and aerosol forcings are combined, the climate models with a realistic 20th century warming indicate that the global mean precipitation increase due to GHG warming has, until recently, been completely masked by aerosol drying. This explains the apparent lack of sensitivity of the global mean precipitation to the net global warming recently found in observations. As the importance of GHG warming increases in the future, a clear signal will emerge. PMID:27386558

  5. A collective neurodynamic optimization approach to bound-constrained nonconvex optimization.

    PubMed

    Yan, Zheng; Wang, Jun; Li, Guocheng

    2014-07-01

    This paper presents a novel collective neurodynamic optimization method for solving nonconvex optimization problems with bound constraints. First, it is proved that a one-layer projection neural network has a property that its equilibria are in one-to-one correspondence with the Karush-Kuhn-Tucker points of the constrained optimization problem. Next, a collective neurodynamic optimization approach is developed by utilizing a group of recurrent neural networks in framework of particle swarm optimization by emulating the paradigm of brainstorming. Each recurrent neural network carries out precise constrained local search according to its own neurodynamic equations. By iteratively improving the solution quality of each recurrent neural network using the information of locally best known solution and globally best known solution, the group can obtain the global optimal solution to a nonconvex optimization problem. The advantages of the proposed collective neurodynamic optimization approach over evolutionary approaches lie in its constraint handling ability and real-time computational efficiency. The effectiveness and characteristics of the proposed approach are illustrated by using many multimodal benchmark functions. PMID:24705545

  6. Optimal stomatal behaviour around the world

    SciTech Connect

    Lin, Yan-Shih; Medlyn, Belinda E.; Duursma, Remko A.; Prentice, I. Colin; Wang, Han; Baig, Sofia; Eamus, Derek; de Dios, Victor Resco; Mitchell, Patrick; Ellsworth, David S.; de Beeck, Maarten Op; Wallin, Göran; Uddling, Johan; Tarvainen, Lasse; Linderson, Maj-Lena; Cernusak, Lucas A.; Nippert, Jesse B.; Ocheltree, Troy W.; Tissue, David T.; Martin-StPaul, Nicolas K.; Rogers, Alistair; Warren, Jeff M.; De Angelis, Paolo; Hikosaka, Kouki; Han, Qingmin; Onoda, Yusuke; Gimeno, Teresa E.; Barton, Craig V. M.; Bennie, Jonathan; Bonal, Damien; Bosc, Alexandre; Löw, Markus; Macinins-Ng, Cate; Rey, Ana; Rowland, Lucy; Setterfield, Samantha A.; Tausz-Posch, Sabine; Zaragoza-Castells, Joana; Broadmeadow, Mark S. J.; Drake, John E.; Freeman, Michael; Ghannoum, Oula; Hutley, Lindsay B.; Kelly, Jeff W.; Kikuzawa, Kihachiro; Kolari, Pasi; Koyama, Kohei; Limousin, Jean-Marc; Meir, Patrick; Lola da Costa, Antonio C.; Mikkelsen, Teis N.; Salinas, Norma; Sun, Wei; Wingate, Lisa

    2015-03-02

    Stomatal conductance (gs) is a key land-surface attribute as it links transpiration, the dominant component of global land evapotranspiration, and photosynthesis, the driving force of the global carbon cycle. Despite the pivotal role of gs in predictions of global water and carbon cycle changes, a global-scale database and an associated globally applicable model of gs that allow predictions of stomatal behaviour are lacking. Here, we present a database of globally distributed gs obtained in the field for a wide range of plant functional types (PFTs) and biomes. We find that stomatal behaviour differs among PFTs according to their marginal carbon cost of water use, as predicted by the theory underpinning the optimal stomatal model1 and the leaf and wood economics spectrum2,3. We also demonstrate a global relationship with climate. In conclusion, these findings provide a robust theoretical framework for understanding and predicting the behaviour of gs across biomes and across PFTs that can be applied to regional, continental and global-scale modelling of ecosystem productivity, energy balance and ecohydrological processes in a future changing climate.

  7. Optimal stomatal behaviour around the world

    DOE PAGESBeta

    Lin, Yan-Shih; Medlyn, Belinda E.; Duursma, Remko A.; Prentice, I. Colin; Wang, Han; Baig, Sofia; Eamus, Derek; de Dios, Victor Resco; Mitchell, Patrick; Ellsworth, David S.; et al

    2015-03-02

    Stomatal conductance (gs) is a key land-surface attribute as it links transpiration, the dominant component of global land evapotranspiration, and photosynthesis, the driving force of the global carbon cycle. Despite the pivotal role of gs in predictions of global water and carbon cycle changes, a global-scale database and an associated globally applicable model of gs that allow predictions of stomatal behaviour are lacking. Here, we present a database of globally distributed gs obtained in the field for a wide range of plant functional types (PFTs) and biomes. We find that stomatal behaviour differs among PFTs according to their marginal carbonmore » cost of water use, as predicted by the theory underpinning the optimal stomatal model1 and the leaf and wood economics spectrum2,3. We also demonstrate a global relationship with climate. In conclusion, these findings provide a robust theoretical framework for understanding and predicting the behaviour of gs across biomes and across PFTs that can be applied to regional, continental and global-scale modelling of ecosystem productivity, energy balance and ecohydrological processes in a future changing climate.« less

  8. Optimal stomatal behaviour around the world

    NASA Astrophysics Data System (ADS)

    Lin, Yan-Shih; Medlyn, Belinda E.; Duursma, Remko A.; Prentice, I. Colin; Wang, Han; Baig, Sofia; Eamus, Derek; de Dios, Victor Resco; Mitchell, Patrick; Ellsworth, David S.; de Beeck, Maarten Op; Wallin, Göran; Uddling, Johan; Tarvainen, Lasse; Linderson, Maj-Lena; Cernusak, Lucas A.; Nippert, Jesse B.; Ocheltree, Troy W.; Tissue, David T.; Martin-Stpaul, Nicolas K.; Rogers, Alistair; Warren, Jeff M.; de Angelis, Paolo; Hikosaka, Kouki; Han, Qingmin; Onoda, Yusuke; Gimeno, Teresa E.; Barton, Craig V. M.; Bennie, Jonathan; Bonal, Damien; Bosc, Alexandre; Löw, Markus; Macinins-Ng, Cate; Rey, Ana; Rowland, Lucy; Setterfield, Samantha A.; Tausz-Posch, Sabine; Zaragoza-Castells, Joana; Broadmeadow, Mark S. J.; Drake, John E.; Freeman, Michael; Ghannoum, Oula; Hutley, Lindsay B.; Kelly, Jeff W.; Kikuzawa, Kihachiro; Kolari, Pasi; Koyama, Kohei; Limousin, Jean-Marc; Meir, Patrick; Lola da Costa, Antonio C.; Mikkelsen, Teis N.; Salinas, Norma; Sun, Wei; Wingate, Lisa

    2015-05-01

    Stomatal conductance (gs) is a key land-surface attribute as it links transpiration, the dominant component of global land evapotranspiration, and photosynthesis, the driving force of the global carbon cycle. Despite the pivotal role of gs in predictions of global water and carbon cycle changes, a global-scale database and an associated globally applicable model of gs that allow predictions of stomatal behaviour are lacking. Here, we present a database of globally distributed gs obtained in the field for a wide range of plant functional types (PFTs) and biomes. We find that stomatal behaviour differs among PFTs according to their marginal carbon cost of water use, as predicted by the theory underpinning the optimal stomatal model and the leaf and wood economics spectrum. We also demonstrate a global relationship with climate. These findings provide a robust theoretical framework for understanding and predicting the behaviour of gs across biomes and across PFTs that can be applied to regional, continental and global-scale modelling of ecosystem productivity, energy balance and ecohydrological processes in a future changing climate.

  9. Optimal Phase Oscillatory Network

    NASA Astrophysics Data System (ADS)

    Follmann, Rosangela

    2013-03-01

    Important topics as preventive detection of epidemics, collective self-organization, information flow and systemic robustness in clusters are typical examples of processes that can be studied in the context of the theory of complex networks. It is an emerging theory in a field, which has recently attracted much interest, involving the synchronization of dynamical systems associated to nodes, or vertices, of the network. Studies have shown that synchronization in oscillatory networks depends not only on the individual dynamics of each element, but also on the combination of the topology of the connections as well as on the properties of the interactions of these elements. Moreover, the response of the network to small damages, caused at strategic points, can enhance the global performance of the whole network. In this presentation we explore an optimal phase oscillatory network altered by an additional term in the coupling function. The application to associative-memory network shows improvement on the correct information retrieval as well as increase of the storage capacity. The inclusion of some small deviations on the nodes, when solutions are attracted to a false state, results in additional enhancement of the performance of the associative-memory network. Supported by FAPESP - Sao Paulo Research Foundation, grant number 2012/12555-4

  10. Optimizing management of glycaemia.

    PubMed

    Chatterjee, Sudesna; Khunti, Kamlesh; Davies, Melanie J

    2016-06-01

    The global epidemic of type 2 diabetes (T2DM) continues largely unabated due to an increasingly sedentary lifestyle and obesogenic environment. A cost-effective patient-centred approach, incorporating glucose-lowering therapy and modification of cardiovascular risk factors, could help prevent the inevitable development and progression of macrovascular and microvascular complications. Glycaemic optimization requires patient structured education, self-management and empowerment, and psychological support along with early and proactive use of glucose lowering therapies, which should be delivered in a system of care as shown by the Chronic Care Model. From diagnosis, intensive glycaemic control and individualised care is aimed at reducing complications. In older people, the goal is maintaining quality of life and minimizing morbidity, especially as overtreatment increases hypoglycaemia risk. Maintaining durable glycaemic control is challenging and complex to achieve without hypoglycaemia, weight gain and other significant adverse effects. Overcoming patient and physician barriers can help ensure adequate treatment initiation and intensification. Cardiovascular safety studies with newer glucose-lowering agents are now mandatory, with a sodium glucose co-transporter-2 inhibitor (empagliflozin), and two glucagon like peptide-1 receptor agonists (liraglutide and semaglutide) being the first to demonstrate superior CV outcomes compared with placebo. PMID:27432074

  11. Optimal hemicube sampling

    SciTech Connect

    Max, N. |

    1992-12-17

    Radiosity algorithms for global illumination, either ``gathering`` or ``shooting`` versions, depend on the calculation of form factors. It is possible to calculate the form factors analytically, but this is difficult when occlusion is involved, so sampling methods are usually preferred. The necessary visibility information can be obtained by ray tracing in the sampled directions. However, area coherence makes it more efficient to project and scan-convert the scene onto a number of planes, for example, the faces of a hemicube. The hemicube faces have traditionally been divided into equal square pixels, but more general subdivisions are practical, and can reduce the variance of the form factor estimates. The hemicube estimates of form factors are based on a finite set of sample directions. We obtain several optimal arrangements of sample directions, which minimize the variance of this estimate. Four approaches are changing the size of the pixels, the shape of the pixels, the shape of the hemicube, or using non-uniform pixel grids. The best approach reduces the variance by 43%. The variance calculation is based on the assumption that the errors in the estimate are caused by the projections of single edges of polygonal patches, and that the positions and orientations of these edges are random.

  12. Optimal hemicube sampling

    SciTech Connect

    Max, N. California Univ., Davis, CA )

    1992-12-17

    Radiosity algorithms for global illumination, either gathering'' or shooting'' versions, depend on the calculation of form factors. It is possible to calculate the form factors analytically, but this is difficult when occlusion is involved, so sampling methods are usually preferred. The necessary visibility information can be obtained by ray tracing in the sampled directions. However, area coherence makes it more efficient to project and scan-convert the scene onto a number of planes, for example, the faces of a hemicube. The hemicube faces have traditionally been divided into equal square pixels, but more general subdivisions are practical, and can reduce the variance of the form factor estimates. The hemicube estimates of form factors are based on a finite set of sample directions. We obtain several optimal arrangements of sample directions, which minimize the variance of this estimate. Four approaches are changing the size of the pixels, the shape of the pixels, the shape of the hemicube, or using non-uniform pixel grids. The best approach reduces the variance by 43%. The variance calculation is based on the assumption that the errors in the estimate are caused by the projections of single edges of polygonal patches, and that the positions and orientations of these edges are random.

  13. The New Global Health

    PubMed Central

    Simone, Patricia M.; Davison, Veronica; Slutsker, Laurence

    2013-01-01

    Global health reflects the realities of globalization, including worldwide dissemination of infectious and noninfectious public health risks. Global health architecture is complex and better coordination is needed between multiple organizations. Three overlapping themes determine global health action and prioritization: development, security, and public health. These themes play out against a background of demographic change, socioeconomic development, and urbanization. Infectious diseases remain critical factors, but are no longer the major cause of global illness and death. Traditional indicators of public health, such as maternal and infant mortality rates no longer describe the health status of whole societies; this change highlights the need for investment in vital registration and disease-specific reporting. Noncommunicable diseases, injuries, and mental health will require greater attention from the world in the future. The new global health requires broader engagement by health organizations and all countries for the objectives of health equity, access, and coverage as priorities beyond the Millennium Development Goals are set. PMID:23876365

  14. Globalization, culture and psychology.

    PubMed

    Melluish, Steve

    2014-10-01

    This article outlines the cultural and psychological effects of globalization. It looks at the impact of globalization on identity; ideas of privacy and intimacy; the way we understand and perceive psychological distress; and the development of the profession of psychology around the world. The article takes a critical perspective on globalization, seeing it as aligned with the spread of neoliberal capitalism, a tendency towards cultural homogenization, the imposition of dominant 'global north' ideas and the resultant growing inequalities in health and well-being. However, it also argues that the increased interconnectedness created by globalization allows for greater acknowledgement of our common humanity and for collective efforts to be developed to tackle what are increasingly global problems. This requires the development of more nuanced understandings of cultural differences and of indigenous psychologies. PMID:25343628

  15. Global health for a globally minded president.

    PubMed

    Daulaire, Nils

    2009-01-01

    President-elect Barack Obama can build on historic initiatives championed by his predecessor in global AIDS and malaria. These should serve as the platform for a more comprehensive and evidence-based set of activities aimed at addressing the major causes of ill health and instability in low-income countries. Obama should launch a new Global Family Health Action Plan aimed at saving the lives of six million children and women annually in impoverished nations. Existing policies driven by U.S. domestic ideological battles, particularly those relating to sexual and reproductive health, should be revised and brought into line with solid science and evidence from the field. PMID:19151008

  16. Hierarchical models and iterative optimization of hybrid systems

    NASA Astrophysics Data System (ADS)

    Rasina, Irina V.; Baturina, Olga V.; Nasatueva, Soelma N.

    2016-06-01

    A class of hybrid control systems on the base of two-level discrete-continuous model is considered. The concept of this model was proposed and developed in preceding works as a concretization of the general multi-step system with related optimality conditions. A new iterative optimization procedure for such systems is developed on the base of localization of the global optimality conditions via contraction the control set.

  17. NASA Global Hawk Overview

    NASA Technical Reports Server (NTRS)

    Naftel, Chris

    2014-01-01

    The NASA Global Hawk Project is supporting Earth Science research customers. These customers include: US Government agencies, civilian organizations, and universities. The combination of the Global Hawks range, endurance, altitude, payload power, payload volume and payload weight capabilities separates the Global Hawk platform from all other platforms available to the science community. This presentation includes an overview of the concept of operations and an overview of the completed science campaigns. In addition, the future science plans, using the NASA Global Hawk System, will be presented.

  18. Multi Objective Aerodynamic Optimization Using Parallel Nash Evolutionary/deterministic Hybrid Algorithms

    NASA Astrophysics Data System (ADS)

    Tang, Zhili

    2016-06-01

    This paper solved aerodynamic drag reduction of transport wing fuselage configuration in transonic regime by using a parallel Nash evolutionary/deterministic hybrid optimization algorithm. Two sets of parameters are used, namely globally and locally. It is shown that optimizing separately local and global parameters by using Nash algorithms is far more efficient than considering these variables as a whole.

  19. Agricultural Water Use under Global Change

    NASA Astrophysics Data System (ADS)

    Zhu, T.; Ringler, C.; Rosegrant, M. W.

    2008-12-01

    Irrigation is by far the single largest user of water in the world and is projected to remain so in the foreseeable future. Globally, irrigated agricultural land comprises less than twenty percent of total cropland but produces about forty percent of the world's food. Increasing world population will require more food and this will lead to more irrigation in many areas. As demands increase and water becomes an increasingly scarce resource, agriculture's competition for water with other economic sectors will be intensified. This water picture is expected to become even more complex as climate change will impose substantial impacts on water availability and demand, in particular for agriculture. To better understand future water demand and supply under global change, including changes in demographic, economic and technological dimensions, the water simulation module of IMPACT, a global water and food projection model developed at the International Food Policy Research Institute, is used to analyze future water demand and supply in agricultural and several non-agricultural sectors using downscaled GCM scenarios, based on water availability simulation done with a recently developed semi-distributed global hydrological model. Risk analysis is conducted to identify countries and regions where future water supply reliability for irrigation is low, and food security may be threatened in the presence of climate change. Gridded shadow values of irrigation water are derived for global cropland based on an optimization framework, and they are used to illustrate potential irrigation development by incorporating gridded water availability and existing global map of irrigation areas.

  20. Cluster optimization simplified by interaction modification

    NASA Astrophysics Data System (ADS)

    Stillinger, Frank H.; Stillinger, Dorothea K.

    1990-10-01

    Even when interactions are known exactly, it is generally very difficult to determine the lowest-energy configuration (a global potential energy minimum) for clusters with more than very few atoms or molecules. In mathematical parlance this is an NP-complete problem. A nonlinear optimization strategy, the ``ant-lion method,'' has been proposed to accelerate the search for global minima, and works by adroitly deforming the potential surface to produce overwhelming dominance by global minimum potential energy basins. This strategy is illustrated by application to clusters of 13 noble gas atoms. Monte Carlo results demonstrate that reduction of p in the pair potential 4(r-2p-r-p) below the ``physical'' value 6 produces a dramatic rise to essentially unity in probability of random encounter with the global minimum basins (icosahedral clusters).

  1. Optimal vaccination and treatment of an epidemic network model

    NASA Astrophysics Data System (ADS)

    Chen, Lijuan; Sun, Jitao

    2014-08-01

    In this Letter, we firstly propose an epidemic network model incorporating two controls which are vaccination and treatment. For the constant controls, by using Lyapunov function, global stability of the disease-free equilibrium and the endemic equilibrium of the model is investigated. For the non-constant controls, by using the optimal control strategy, we discuss an optimal strategy to minimize the total number of the infected and the cost associated with vaccination and treatment. Table 1 and Figs. 1-5 are presented to show the global stability and the efficiency of this optimal control.

  2. A multiobjective memetic algorithm based on particle swarm optimization.

    PubMed

    Liu, Dasheng; Tan, K C; Goh, C K; Ho, W K

    2007-02-01

    In this paper, a new memetic algorithm (MA) for multiobjective (MO) optimization is proposed, which combines the global search ability of particle swarm optimization with a synchronous local search heuristic for directed local fine-tuning. A new particle updating strategy is proposed based upon the concept of fuzzy global-best to deal with the problem of premature convergence and diversity maintenance within the swarm. The proposed features are examined to show their individual and combined effects in MO optimization. The comparative study shows the effectiveness of the proposed MA, which produces solution sets that are highly competitive in terms of convergence, diversity, and distribution. PMID:17278557

  3. Role of control constraints in quantum optimal control

    NASA Astrophysics Data System (ADS)

    Zhdanov, Dmitry V.; Seideman, Tamar

    2015-11-01

    The problems of optimizing the value of an arbitrary observable of a two-level system at both a fixed time and the shortest possible time is theoretically explored. Complete identification and classification along with comprehensive analysis of globally optimal control policies and traps (i.e., policies which are locally but not globally optimal) are presented. The central question addressed is whether the control landscape remains trap-free if control constraints of the inequality type are imposed. The answer is astonishingly controversial: Although the traps are proven always to exist in this case, in practice they become trivially escapable once the control time is fixed and chosen long enough.

  4. From Global Knowledge to Global Civic Engagement

    ERIC Educational Resources Information Center

    Lorenzini, Michelle

    2013-01-01

    In this article, I argue that student learning is enhanced when civic engagement is a component of international education initiatives. When only presented with knowledge about global challenges, students can become frustrated and overwhelmed unless they also understand how they might contribute to solutions. Political science programs are…

  5. "Global Competency" Is Imperative for Global Success

    ERIC Educational Resources Information Center

    Reimers, Fernando

    2009-01-01

    According to a recent report of scenarios prepared by the National Intelligence Council, the next 15 years will bring significant global changes, including the transformation of the international political system built after World War II, a transfer of wealth from the West to the East, pressure on natural resources resulting from continuing…

  6. Learning to Plunder: Global Education, Global Inequality and the Global City

    ERIC Educational Resources Information Center

    Tannock, Stuart

    2010-01-01

    Most research and policy discussions of education in the global city have focused on the ways in which globalization and the emergence of global or globalizing cities can create social, economic and educational inequality locally, within the global city itself. Global cities, however, are, by definition, powerful places, where the core…

  7. Optimal Control via Self-Generated Stochasticity

    NASA Technical Reports Server (NTRS)

    Zak, Michail

    2011-01-01

    The problem of global maxima of functionals has been examined. Mathematical roots of local maxima are the same as those for a much simpler problem of finding global maximum of a multi-dimensional function. The second problem is instability even if an optimal trajectory is found, there is no guarantee that it is stable. As a result, a fundamentally new approach is introduced to optimal control based upon two new ideas. The first idea is to represent the functional to be maximized as a limit of a probability density governed by the appropriately selected Liouville equation. Then, the corresponding ordinary differential equations (ODEs) become stochastic, and that sample of the solution that has the largest value will have the highest probability to appear in ODE simulation. The main advantages of the stochastic approach are that it is not sensitive to local maxima, the function to be maximized must be only integrable but not necessarily differentiable, and global equality and inequality constraints do not cause any significant obstacles. The second idea is to remove possible instability of the optimal solution by equipping the control system with a self-stabilizing device. The applications of the proposed methodology will optimize the performance of NASA spacecraft, as well as robot performance.

  8. Collaboration pathway(s) using new tools for optimizing operational climate monitoring from space

    NASA Astrophysics Data System (ADS)

    Helmuth, Douglas B.; Selva, Daniel; Dwyer, Morgan M.

    2014-10-01

    Consistently collecting the earth's climate signatures remains a priority for world governments and international scientific organizations. Architecting a solution requires transforming scientific missions into an optimized robust `operational' constellation that addresses the needs of decision makers, scientific investigators and global users for trusted data. The application of new tools offers pathways for global architecture collaboration. Recent (2014) rulebased decision engine modeling runs that targeted optimizing the intended NPOESS architecture, becomes a surrogate for global operational climate monitoring architecture(s). This rule-based systems tools provide valuable insight for Global climate architectures, through the comparison and evaluation of alternatives considered and the exhaustive range of trade space explored. A representative optimization of Global ECV's (essential climate variables) climate monitoring architecture(s) is explored and described in some detail with thoughts on appropriate rule-based valuations. The optimization tools(s) suggest and support global collaboration pathways and hopefully elicit responses from the audience and climate science shareholders.

  9. Preparing Global Citizens

    ERIC Educational Resources Information Center

    Roberts, Dennis C.; Welch, Lucas; Al-Khanji, Khalid

    2013-01-01

    Global citizens are those who are aware of, demonstrate respect for, and are comfortable engaging across cultural boundaries. This article explores why preparing global citizens is important and how positive psychology can inform our understanding of those who engage comfortably in today's complicated world. Soliya's Connect program is described…

  10. Global Education: An Overview.

    ERIC Educational Resources Information Center

    Becker, James M.

    1988-01-01

    Discusses the different definitions and conceptualizations of global education, stating that much of the traditional curriculum of international studies can be reinterpreted to prepare students to participate in an interdependent society. Gives nine objectives for global education, and delineates the issues surrounding current conceptions of…

  11. Poverty + Hunger = Global Issues.

    ERIC Educational Resources Information Center

    Schwartz, Richard H.

    1983-01-01

    Geography teachers can use mathematics to teach fourth, fifth, and sixth grade students about critical global issues. Five sample problems concerning population, poverty, waste, the arms race, and hunger are presented. The global issue related to each problem is discussed, and the solution and mathematical skill are provided. (RM)

  12. Defining Global Education

    ERIC Educational Resources Information Center

    Molina, Sarina; Lattimer, Heather

    2013-01-01

    As the world is becoming increasingly flat, it has become important for educators to prepare students to understand global perspectives and engage with people from countries and cultures around the world. Although there is no question as to the importance of global education to meet with the demands of a flat world, what internationalization and…

  13. Global Diversity and Leadership.

    ERIC Educational Resources Information Center

    Ruiz, Art

    2003-01-01

    Argues that global diversity has become a business imperative in today's business climate. Global diversity is of core importance even for companies that are considered domestic. Suggests community colleges need help in understanding their customer base and their shifting values in order to meet their needs and win customer loyalty. (NB)

  14. Globally Collaborative Experiential Learning

    ERIC Educational Resources Information Center

    Utsumi, Takeshi

    2005-01-01

    The Global University System (GUS) [Utsumi, et al, 2003] is a worldwide initiative to create advanced telecommunications infrastructure for access to educational resources across national and cultural boundaries for global peace. GUS aims to create a worldwide consortium of universities to provide the underdeveloped world with access to 21st…

  15. Building Global Learning Communities

    ERIC Educational Resources Information Center

    Cochrane, Thomas; Buchem, Ilona; Camacho, Mar; Cronin, Catherine; Gordon, Averill; Keegan, Helen

    2013-01-01

    Within the background where education is increasingly driven by the economies of scale and research funding, we propose an alternative online open and connected framework (OOC) for building global learning communities using mobile social media. We critique a three year action research case study involving building collaborative global learning…

  16. Globalism and HRD. Symposium.

    ERIC Educational Resources Information Center

    2002

    This document contains three papers from a symposium on globalization and human resource development (HRD). "Challenges and Strategies of Developing Human Resources in the Surge of Globalization: A Case of the People's Republic of China" (De Zhang, Baiyin Yang, Yichi Zhang) analyzes the challenges and strategies of HRD in China and discusses the…

  17. Global Managers' Career Competencies

    ERIC Educational Resources Information Center

    Cappellen, Tineke; Janssens, Maddy

    2008-01-01

    Purpose: This study aims to empirically examine the career competencies of global managers having world-wide coordination responsibility: knowing-why, knowing-how and knowing-whom career competencies. Design/methodology/approach: Based on in-depth interviews with 45 global managers, the paper analyzes career stories from a content analysis…

  18. The Global Thinking Project.

    ERIC Educational Resources Information Center

    Hassard, Jack; Weisburg, Julie

    1992-01-01

    Describes the Global Thinking Project, a collaborative effort between Georgia State University and the Russian Academy of Pedagogical Sciences to develop strategies, methods, and teaching materials to help students think globally. Students are connected through the AppleLink network. Student and teacher attitudes toward the project are reported.…

  19. Globalization, Interdependence and Education

    ERIC Educational Resources Information Center

    Neubauer, Deane

    2007-01-01

    Contemporary globalization is marked by rapidly and dramatically increasing interdependence, which operates both within and among countries. Increasing global interdependence has profound influence on education at all levels, such as how to deal with a world with more permeable boundaries in which people are on the move more frequently (migration)…

  20. Global Interaction in Design

    ERIC Educational Resources Information Center

    Bennett, Audrey Grace

    2010-01-01

    Based on a virtual conference, Glide'08 (Global Interaction in Design Education), that brought international design scholars together online, this special issue expands on the topics of cross-cultural communication and design and the technological affordances that support such interaction. The author discusses the need for global interaction in…

  1. Global 2000 Countdown Kit.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    Fourteen units for high school global education classes are based on "The Global 2000 Report to the President," which examines the relationships between worldwide population growth and resource and environmental consequences. Topics of the units are population; income; food; fisheries; forests; water; nonfuel minerals; energy; impacts on…

  2. Critically Theorizing the Global

    ERIC Educational Resources Information Center

    Gaudelli, William

    2013-01-01

    Globalization has unleashed profound changes in education. These include positivistic international school comparisons, a singular focus on schools as drivers of economic development, and the adoption of neoliberal market principles in school. These changes, however, generally go unexamined within the field and literature of global education.…

  3. Globalization of Management Education

    ERIC Educational Resources Information Center

    Bruner, Robert F.; Iannarelli, Juliane

    2011-01-01

    A new study, sponsored by the Association to Advance Collegiate Schools of Business, presented a comprehensive new perspective on the globalization of management education, (AACSB International, 2011). Its findings are sobering: with regard to emerging global trends in higher education and cross-border business, the report reveals a sizable gap…

  4. Assessing Individuals' Global Perspective

    ERIC Educational Resources Information Center

    Merrill, Kelly Carter; Braskamp, David C.; Braskamp, Larry A.

    2012-01-01

    This article introduces the Global Perspective Inventory (GPI), a survey instrument that measures participants' global perspective in terms of cognitive, intrapersonal, and interpersonal domains--each in terms of both development and acquisition. A summary of the recent research on the GPI is provided along with a discussion of potential uses.

  5. Translation as (Global) Writing

    ERIC Educational Resources Information Center

    Horner, Bruce; Tetreault, Laura

    2016-01-01

    This article explores translation as a useful point of departure and framework for taking a translingual approach to writing engaging globalization. Globalization and the knowledge economy are putting renewed emphasis on translation as a key site of contest between a dominant language ideology of monolingualism aligned with fast capitalist…

  6. Teaching Global Society.

    ERIC Educational Resources Information Center

    Peet, Richard

    2002-01-01

    Describes the course, "Global Society," for first-year International Studies students at a Massachusetts liberal arts college. The course, which takes a historical approach, informs students about the nature, history, and present characteristics of the global system, taking theoretical, historical, and critical approaches that stress the…

  7. Simulating Global Climate Summits

    ERIC Educational Resources Information Center

    Vesperman, Dean P.; Haste, Turtle; Alrivy, Stéphane

    2014-01-01

    One of the most persistent and controversial issues facing the global community is climate change. With the creation of the UN Framework Convention on Climate Change (UNFCCC) in 1992 and the Kyoto Protocol (1997), the global community established some common ground on how to address this issue. However, the last several climate summits have failed…

  8. Global Wind Map

    ERIC Educational Resources Information Center

    Journal of College Science Teaching, 2005

    2005-01-01

    This brief article describes a new global wind-power map that has quantified global wind power and may help planners place turbines in locations that can maximize power from the winds and provide widely available low-cost energy. The researchers report that their study can assist in locating wind farms in regions known for strong and consistent…

  9. Turbomachinery Airfoil Design Optimization Using Differential Evolution

    NASA Technical Reports Server (NTRS)

    Madavan, Nateri K.; Biegel, Bryan (Technical Monitor)

    2002-01-01

    An aerodynamic design optimization procedure that is based on a evolutionary algorithm known at Differential Evolution is described. Differential Evolution is a simple, fast, and robust evolutionary strategy that has been proven effective in determining the global optimum for several difficult optimization problems, including highly nonlinear systems with discontinuities and multiple local optima. The method is combined with a Navier-Stokes solver that evaluates the various intermediate designs and provides inputs to the optimization procedure. An efficient constraint handling mechanism is also incorporated. Results are presented for the inverse design of a turbine airfoil from a modern jet engine and compared to earlier methods. The capability of the method to search large design spaces and obtain the optimal airfoils in an automatic fashion is demonstrated. Substantial reductions in the overall computing time requirements are achieved by using the algorithm in conjunction with neural networks.

  10. Aerodynamic Shape Optimization Using Hybridized Differential Evolution

    NASA Technical Reports Server (NTRS)

    Madavan, Nateri K.

    2003-01-01

    An aerodynamic shape optimization method that uses an evolutionary algorithm known at Differential Evolution (DE) in conjunction with various hybridization strategies is described. DE is a simple and robust evolutionary strategy that has been proven effective in determining the global optimum for several difficult optimization problems. Various hybridization strategies for DE are explored, including the use of neural networks as well as traditional local search methods. A Navier-Stokes solver is used to evaluate the various intermediate designs and provide inputs to the hybrid DE optimizer. The method is implemented on distributed parallel computers so that new designs can be obtained within reasonable turnaround times. Results are presented for the inverse design of a turbine airfoil from a modern jet engine. (The final paper will include at least one other aerodynamic design application). The capability of the method to search large design spaces and obtain the optimal airfoils in an automatic fashion is demonstrated.

  11. Turbomachinery Airfoil Design Optimization Using Differential Evolution

    NASA Technical Reports Server (NTRS)

    Madavan, Nateri K.; Biegel, Bryan A. (Technical Monitor)

    2002-01-01

    An aerodynamic design optimization procedure that is based on a evolutionary algorithm known at Differential Evolution is described. Differential Evolution is a simple, fast, and robust evolutionary strategy that has been proven effective in determining the global optimum for several difficult optimization problems, including highly nonlinear systems with discontinuities and multiple local optima. The method is combined with a Navier-Stokes solver that evaluates the various intermediate designs and provides inputs to the optimization procedure. An efficient constraint handling mechanism is also incorporated. Results are presented for the inverse design of a turbine airfoil from a modern jet engine. The capability of the method to search large design spaces and obtain the optimal airfoils in an automatic fashion is demonstrated. Substantial reductions in the overall computing time requirements are achieved by using the algorithm in conjunction with neural networks.

  12. Global Health Education in Pulmonary and Critical Care Medicine Fellowships.

    PubMed

    Siddharthan, Trishul; North, Crystal M; Attia, Engi F; Christiani, David C; Checkley, William; West, T Eoin

    2016-06-01

    A growing number of pulmonary and critical care medicine fellowship programs in the United States offer global health training opportunities. Formal, integrated global health programs within pulmonary and critical care fellowships are relatively new but are built on principles and ideals of global health that focus on the mutually beneficial exchange of knowledge and social justice. Although core competencies consistent with these overarching themes in global health education have not been formalized for pulmonary and critical care trainees, relevant competency areas include clinical knowledge, international research training, cultural competency, and clinical and research capacity building. Existing global health education in U.S. pulmonary and critical care medicine training programs can generally be classified as one of three different models: integrated global health tracks, global health electives, and additional research years. Successful global health education programs foster partnerships and collaborations with international sites that emphasize bidirectional exchange. This bidirectional exchange includes ongoing, equitable commitments to mutual opportunities for training and professional development, including a focus on the particular knowledge and skill sets critical for addressing the unique priorities of individual countries. However, barriers related to the availability of mentorship, funding, and dedicated time exist to expanding global health education in pulmonary and critical care medicine. The implementation of global health training within pulmonary and critical care medicine programs requires continued optimization, but this training is essential to prepare the next generation of physicians to address the global aspects of respiratory disease and critical illness. PMID:26974557

  13. Fuzzy set applications in engineering optimization: Multilevel fuzzy optimization

    NASA Technical Reports Server (NTRS)

    Diaz, Alejandro R.

    1989-01-01

    A formulation for multilevel optimization with fuzzy objective functions is presented. With few exceptions, formulations for fuzzy optimization have dealt with a one-level problem in which the objective is the membership function of a fuzzy set formed by the fuzzy intersection of other sets. In the problem examined here, the goal set G is defined in a more general way, using an aggregation operator H that allows arbitrary combinations of set operations (union, intersection, addition) on the individual sets Gi. This is a straightforward extension of the standard form, but one that makes possible the modeling of interesting evaluation strategies. A second, more important departure from the standard form will be the construction of a multilevel problem analogous to the design decomposition problem in optimization. This arrangement facilitates the simulation of a system design process in which different components of the system are designed by different teams, and different levels of design detail become relevant at different time stages in the process: global design features early, local features later in the process.

  14. Global value trees.

    PubMed

    Zhu, Zhen; Puliga, Michelangelo; Cerina, Federica; Chessa, Alessandro; Riccaboni, Massimo

    2015-01-01

    The fragmentation of production across countries has become an important feature of the globalization in recent decades and is often conceptualized by the term "global value chains" (GVCs). When empirically investigating the GVCs, previous studies are mainly interested in knowing how global the GVCs are rather than how the GVCs look like. From a complex networks perspective, we use the World Input-Output Database (WIOD) to study the evolution of the global production system. We find that the industry-level GVCs are indeed not chain-like but are better characterized by the tree topology. Hence, we compute the global value trees (GVTs) for all the industries available in the WIOD. Moreover, we compute an industry importance measure based on the GVTs and compare it with other network centrality measures. Finally, we discuss some future applications of the GVTs. PMID:25978067

  15. Global Value Trees

    PubMed Central

    Zhu, Zhen; Puliga, Michelangelo; Cerina, Federica; Chessa, Alessandro; Riccaboni, Massimo

    2015-01-01

    The fragmentation of production across countries has become an important feature of the globalization in recent decades and is often conceptualized by the term “global value chains” (GVCs). When empirically investigating the GVCs, previous studies are mainly interested in knowing how global the GVCs are rather than how the GVCs look like. From a complex networks perspective, we use the World Input-Output Database (WIOD) to study the evolution of the global production system. We find that the industry-level GVCs are indeed not chain-like but are better characterized by the tree topology. Hence, we compute the global value trees (GVTs) for all the industries available in the WIOD. Moreover, we compute an industry importance measure based on the GVTs and compare it with other network centrality measures. Finally, we discuss some future applications of the GVTs. PMID:25978067

  16. Globalization and Health.

    PubMed

    Martin, Greg

    2005-04-22

    This debut editorial of Globalization and Health introduces the journal, briefly delineating its goals and objectives and outlines its scope of subject matter. 'Open Access' publishing is expected to become an increasingly important format for peer reviewed academic journals and that Globalization and Health is 'Open Access' is appropriate. The rationale behind starting a journal dedicated to globalization and health is three fold:Firstly: Globalization is reshaping the social geography within which we might strive to create health or prevent disease. The determinants of health - be they a SARS virus or a predilection for fatty foods - have joined us in our global mobility. Driven by economic liberalization and changing technologies, the phenomenon of 'access' is likely to dominate to an increasing extent the unfolding experience of human disease and wellbeing.Secondly: Understanding globalization as a subject matter itself needs certain benchmarks and barometers of its successes and failings. Health is one such barometer. It is a marker of social infrastructure and social welfare and as such can be used to either sound an alarm or give a victory cheer as our interconnectedness hurts and heals the populations we serve.And lastly: In as much as globalization can have an effect on health, it is also true that health and disease has an effect on globalization as exemplified by the existence of quarantine laws and the devastating economic effects of the AIDS pandemic.A balanced view would propose that the effects of globalization on health (and health systems) are neither universally good nor bad, but rather context specific. If the dialogue pertaining to globalization is to be directed or biased in any direction, then it must be this: that we consider the poor first. PMID:15847699

  17. Involute composite design evaluation using global design sensitivity derivatives

    NASA Technical Reports Server (NTRS)

    Hart, J. K.; Stanton, E. L.

    1989-01-01

    An optimization capability for involute structures has been developed. Its key feature is the use of global material geometry variables which are so chosen that all combinations of design variables within a set of lower and upper bounds correspond to manufacturable designs. A further advantage of global variables is that their number does not increase with increasing mesh density. The accuracy of the sensitivity derivatives has been verified both through finite difference tests and through the successful use of the derivatives by an optimizer. The state of the art in composite design today is still marked by point design algorithms linked together using ad hoc methods not directly related to a manufacturing procedure. The global design sensitivity approach presented here for involutes can be applied to filament wound shells and other composite constructions using material form features peculiar to each construction. The present involute optimization technology is being applied to the Space Shuttle SRM nozzle boot ring redesigns by PDA Engineering.

  18. Particle Swarm Optimization Toolbox

    NASA Technical Reports Server (NTRS)

    Grant, Michael J.

    2010-01-01

    The Particle Swarm Optimization Toolbox is a library of evolutionary optimization tools developed in the MATLAB environment. The algorithms contained in the library include a genetic algorithm (GA), a single-objective particle swarm optimizer (SOPSO), and a multi-objective particle swarm optimizer (MOPSO). Development focused on both the SOPSO and MOPSO. A GA was included mainly for comparison purposes, and the particle swarm optimizers appeared to perform better for a wide variety of optimization problems. All algorithms are capable of performing unconstrained and constrained optimization. The particle swarm optimizers are capable of performing single and multi-objective optimization. The SOPSO and MOPSO algorithms are based on swarming theory and bird-flocking patterns to search the trade space for the optimal solution or optimal trade in competing objectives. The MOPSO generates Pareto fronts for objectives that are in competition. A GA, based on Darwin evolutionary theory, is also included in the library. The GA consists of individuals that form a population in the design space. The population mates to form offspring at new locations in the design space. These offspring contain traits from both of the parents. The algorithm is based on this combination of traits from parents to hopefully provide an improved solution than either of the original parents. As the algorithm progresses, individuals that hold these optimal traits will emerge as the optimal solutions. Due to the generic design of all optimization algorithms, each algorithm interfaces with a user-supplied objective function. This function serves as a "black-box" to the optimizers in which the only purpose of this function is to evaluate solutions provided by the optimizers. Hence, the user-supplied function can be numerical simulations, analytical functions, etc., since the specific detail of this function is of no concern to the optimizer. These algorithms were originally developed to support entry

  19. Aristos Optimization Package

    Energy Science and Technology Software Center (ESTSC)

    2007-03-01

    Aristos is a Trilinos package for nonlinear continuous optimization, based on full-space sequential quadratic programming (SQP) methods. Aristos is specifically designed for the solution of large-scale constrained optimization problems in which the linearized constraint equations require iterative (i.e. inexact) linear solver techniques. Aristos' unique feature is an efficient handling of inexactness in linear system solves. Aristos currently supports the solution of equality-constrained convex and nonconvex optimization problems. It has been used successfully in the areamore » of PDE-constrained optimization, for the solution of nonlinear optimal control, optimal design, and inverse problems.« less

  20. Combined control-structure optimization

    NASA Technical Reports Server (NTRS)

    Salama, M.; Milman, M.; Bruno, R.; Scheid, R.; Gibson, S.

    1989-01-01

    An approach for combined control-structure optimization keyed to enhancing early design trade-offs is outlined and illustrated by numerical examples. The approach employs a homotopic strategy and appears to be effective for generating families of designs that can be used in these early trade studies. Analytical results were obtained for classes of structure/control objectives with linear quadratic Gaussian (LQG) and linear quadratic regulator (LQR) costs. For these, researchers demonstrated that global optima can be computed for small values of the homotopy parameter. Conditions for local optima along the homotopy path were also given. Details of two numerical examples employing the LQR control cost were given showing variations of the optimal design variables along the homotopy path. The results of the second example suggest that introducing a second homotopy parameter relating the two parts of the control index in the LQG/LQR formulation might serve to enlarge the family of Pareto optima, but its effect on modifying the optimal structural shapes may be analogous to the original parameter lambda.

  1. A novel stochastic optimization algorithm.

    PubMed

    Li, B; Jiang, W

    2000-01-01

    This paper presents a new stochastic approach SAGACIA based on proper integration of simulated annealing algorithm (SAA), genetic algorithm (GA), and chemotaxis algorithm (CA) for solving complex optimization problems. SAGACIA combines the advantages of SAA, GA, and CA together. It has the following features: (1) it is not the simple mix of SAA, GA, and CA; (2) it works from a population; (3) it can be easily used to solve optimization problems either with continuous variables or with discrete variables, and it does not need coding and decoding,; and (4) it can easily escape from local minima and converge quickly. Good solutions can be obtained in a very short time. The search process of SAGACIA can be explained with Markov chains. In this paper, it is proved that SAGACIA has the property of global asymptotical convergence. SAGACIA has been applied to solve such problems as scheduling, the training of artificial neural networks, and the optimizing of complex functions. In all the test cases, the performance of SAGACIA is better than that of SAA, GA, and CA. PMID:18244742

  2. Foraging on the potential energy surface: a swarm intelligence-based optimizer for molecular geometry.

    PubMed

    Wehmeyer, Christoph; Falk von Rudorff, Guido; Wolf, Sebastian; Kabbe, Gabriel; Schärf, Daniel; Kühne, Thomas D; Sebastiani, Daniel

    2012-11-21

    We present a stochastic, swarm intelligence-based optimization algorithm for the prediction of global minima on potential energy surfaces of molecular cluster structures. Our optimization approach is a modification of the artificial bee colony (ABC) algorithm which is inspired by the foraging behavior of honey bees. We apply our modified ABC algorithm to the problem of global geometry optimization of molecular cluster structures and show its performance for clusters with 2-57 particles and different interatomic interaction potentials. PMID:23181297

  3. Foraging on the potential energy surface: A swarm intelligence-based optimizer for molecular geometry

    NASA Astrophysics Data System (ADS)

    Wehmeyer, Christoph; Falk von Rudorff, Guido; Wolf, Sebastian; Kabbe, Gabriel; Schärf, Daniel; Kühne, Thomas D.; Sebastiani, Daniel

    2012-11-01

    We present a stochastic, swarm intelligence-based optimization algorithm for the prediction of global minima on potential energy surfaces of molecular cluster structures. Our optimization approach is a modification of the artificial bee colony (ABC) algorithm which is inspired by the foraging behavior of honey bees. We apply our modified ABC algorithm to the problem of global geometry optimization of molecular cluster structures and show its performance for clusters with 2-57 particles and different interatomic interaction potentials.

  4. Centerline optimization using vessel quantification model

    NASA Astrophysics Data System (ADS)

    Cai, Wenli; Dachille, Frank; Meissner, Michael

    2005-04-01

    An accurate and reproducible centerline is needed in many vascular applications, such as virtual angioscopy, vessel quantification, and surgery planning. This paper presents a progressive optimization algorithm to refine a centerline after it is extracted. A new centerline model definition is proposed that allows quantifiable minimum cross-sectional area. A centerline is divided into a number of segments. Each segment corresponds to a local generalized cylinder. A reference frame (cross-section) is set up at the center point of each cylinder. The position and the orientation of the cross-section are optimized within each cylinder by finding the minimum cross-sectional area. All local-optimized center points are approximated by a NURBS curve globally, and the curve is re-sampled to the refined set of center points. This refinement iteration, local optimization plus global approximation, converges to the optimal centerline, yielding a smooth and accurate central axis curve. The application discussed in this paper is vessel quantification and virtual angioscopy. However, the algorithm is a general centerline refinement method that can be applied to other applications that need accurate and reproducible centerlines.

  5. Global Oral Health Inequalities

    PubMed Central

    Garcia, I.; Tabak, L.A.

    2011-01-01

    Despite impressive worldwide improvements in oral health, inequalities in oral health status among and within countries remain a daunting public health challenge. Oral health inequalities arise from a complex web of health determinants, including social, behavioral, economic, genetic, environmental, and health system factors. Eliminating these inequalities cannot be accomplished in isolation of oral health from overall health, or without recognizing that oral health is influenced at multiple individual, family, community, and health systems levels. For several reasons, this is an opportune time for global efforts targeted at reducing oral health inequalities. Global health is increasingly viewed not just as a humanitarian obligation, but also as a vehicle for health diplomacy and part of the broader mission to reduce poverty, build stronger economies, and strengthen global security. Despite the global economic recession, there are trends that portend well for support of global health efforts: increased globalization of research and development, growing investment from private philanthropy, an absolute growth of spending in research and innovation, and an enhanced interest in global health among young people. More systematic and far-reaching efforts will be required to address oral health inequalities through the engagement of oral health funders and sponsors of research, with partners from multiple public and private sectors. The oral health community must be “at the table” with other health disciplines and create opportunities for eliminating inequalities through collaborations that can harness both the intellectual and financial resources of multiple sectors and institutions. PMID:21490232

  6. How global brands compete.

    PubMed

    Holt, Douglas B; Quelch, John A; Taylor, Earl L

    2004-09-01

    It's time to rethink global branding. More than two decades ago, Harvard Business School professor Theodore Levitt argued that corporations should grow by selling standardized products all over the world. But consumers in most countries had trouble relating to generic products, so executives instead strove for global scale on backstage activities such as production while customizing product features and selling techniques to local tastes. Such "glocal" strategies now rule marketing. Global branding has lost more luster recently because transnational companies have been under siege, with brands like Coca-Cola and Nike becoming lightning rods for antiglobalization protests. The instinctive reaction of most transnational companies has been to try to fly below the radar. But global brands can't escape notice. In fact, most transnational corporations don't realize that because of their power and pervasiveness, people view them differently than they do other firms. In a research project involving 3,300 consumers in 41 countries, the authors found that most people choose one global brand over another because of differences in the brands'global qualities. Ratherthan ignore the global characteristics of their brands, firms must learn to manage those characteristics. That's critical, because future growth for most companies will likely come from foreign markets. Consumers base preferences on three dimensions of global brands--quality (signaled by a company's global stature); the cultural myths that brands author; and firms' efforts to address social problems. The authors also found that it didn't matter to consumers whether the brands they bought were American--a remarkable finding considering that the study was conducted when anti-American sentiment in many nations was on the rise. PMID:15449856

  7. Partial differential equations constrained combinatorial optimization on an adiabatic quantum computer

    NASA Astrophysics Data System (ADS)

    Chandra, Rishabh

    Partial differential equation-constrained combinatorial optimization (PDECCO) problems are a mixture of continuous and discrete optimization problems. PDECCO problems have discrete controls, but since the partial differential equations (PDE) are continuous, the optimization space is continuous as well. Such problems have several applications, such as gas/water network optimization, traffic optimization, micro-chip cooling optimization, etc. Currently, no efficient classical algorithm which guarantees a global minimum for PDECCO problems exists. A new mapping has been developed that transforms PDECCO problem, which only have linear PDEs as constraints, into quadratic unconstrained binary optimization (QUBO) problems that can be solved using an adiabatic quantum optimizer (AQO). The mapping is efficient, it scales polynomially with the size of the PDECCO problem, requires only one PDE solve to form the QUBO problem, and if the QUBO problem is solved correctly and efficiently on an AQO, guarantees a global optimal solution for the original PDECCO problem.

  8. Design criteria for optimal photosynthetic energy conversion

    NASA Astrophysics Data System (ADS)

    Fingerhut, Benjamin P.; Zinth, Wolfgang; de Vivie-Riedle, Regina

    2008-12-01

    Photochemical solar energy conversion is considered as an alternative of clean energy. For future light converting nano-machines photosynthetic reaction centers are used as prototypes optimized during evolution. We introduce a reaction scheme for global optimization and simulate the ultrafast charge separation in photochemical energy conversion. Multiple molecular charge carriers are involved in this process and are linked by Marcus-type electron transfer. In combination with evolutionary algorithms, we unravel the biological strategies for high quantum efficiency in photosynthetic reaction centers and extend these concepts to the design of artificial photochemical devices for energy conversion.

  9. Optimal response rates in humans and rats

    PubMed Central

    Freestone, David M.; Balcı, Fuat; Simen, Patrick; Church, Russell M.

    2015-01-01

    The analysis of response rates has been highly influential in psychology, giving rise to many prominent theories of learning. There is, however, growing interest in explaining response rates, not as a global response to associations or value, but as a decision about how to space responses in time. Recently, researchers have shown that humans and mice can time a single response optimally, i.e., in a way that maximizes reward. Here, we use the well-established DRL timing task to show that humans and rats come close to optimizing reinforcement rate, but respond systematically faster than they should. PMID:25706545

  10. Parallel Computational Environment for Substructure Optimization

    NASA Technical Reports Server (NTRS)

    Gendy, Atef S.; Patnaik, Surya N.; Hopkins, Dale A.; Berke, Laszlo

    1995-01-01

    Design optimization of large structural systems can be attempted through a substructure strategy when convergence difficulties are encountered. When this strategy is used, the large structure is divided into several smaller substructures and a subproblem is defined for each substructure. The solution of the large optimization problem can be obtained iteratively through repeated solutions of the modest subproblems. Substructure strategies, in sequential as well as in parallel computational modes on a Cray YMP multiprocessor computer, have been incorporated in the optimization test bed CometBoards. CometBoards is an acronym for Comparative Evaluation Test Bed of Optimization and Analysis Routines for Design of Structures. Three issues, intensive computation, convergence of the iterative process, and analytically superior optimum, were addressed in the implementation of substructure optimization into CometBoards. Coupling between subproblems as well as local and global constraint grouping are essential for convergence of the iterative process. The substructure strategy can produce an analytically superior optimum different from what can be obtained by regular optimization. For the problems solved, substructure optimization in a parallel computational mode made effective use of all assigned processors.

  11. Globalization and health.

    PubMed

    Walt, G

    2001-01-01

    Globalization means different things to different people; a general definition is the increasing movement of information, material and people across borders. It can be considered in terms of five conflicting but inter-relating themes, economic transformation; new patterns of trade; an increasing poverty gap associated with widening health inequalities; the revolution in electronic communication; and the growing role of non-state actors, such as non-governmental organizations and transnational corporations, in global governance. Globalization is both an opportunity and a threat, but it is not inexorable. Successful action against its undesirable aspects is possible. PMID:11339346

  12. Global atmospheric changes.

    PubMed Central

    Piver, W T

    1991-01-01

    Increasing concentrations of CO2 and other greenhouse gases in the atmosphere can be directly related to global warming. In terms of human health, because a major cause of increasing atmospheric concentrations of CO2 is the increased combustion of fossil fuels, global warming also may result in increases in air pollutants, acid deposition, and exposure to ultraviolet (UV) radiation. To understand better the impacts of global warming phenomena on human health, this review emphasizes the processes that are responsible for the greenhouse effect, air pollution, acid deposition, and increased exposure to UV radiation. PMID:1820255

  13. Multidisciplinary Optimization for Aerospace Using Genetic Optimization

    NASA Technical Reports Server (NTRS)

    Pak, Chan-gi; Hahn, Edward E.; Herrera, Claudia Y.

    2007-01-01

    In support of the ARMD guidelines NASA's Dryden Flight Research Center is developing a multidisciplinary design and optimization tool This tool will leverage existing tools and practices, and allow the easy integration and adoption of new state-of-the-art software. Optimization has made its way into many mainstream applications. For example NASTRAN(TradeMark) has its solution sequence 200 for Design Optimization, and MATLAB(TradeMark) has an Optimization Tool box. Other packages, such as ZAERO(TradeMark) aeroelastic panel code and the CFL3D(TradeMark) Navier-Stokes solver have no built in optimizer. The goal of the tool development is to generate a central executive capable of using disparate software packages ina cross platform network environment so as to quickly perform optimization and design tasks in a cohesive streamlined manner. A provided figure (Figure 1) shows a typical set of tools and their relation to the central executive. Optimization can take place within each individual too, or in a loop between the executive and the tool, or both.

  14. Optimization of aerospace structures

    NASA Technical Reports Server (NTRS)

    Keith, Theo G., Jr.; Patnaik, Surya N.

    1994-01-01

    Research carried out is grouped under two topics: (1) Design Optimization, and (2) Integrated Force Method of Analysis. Design Optimization Research Topics are singularity alleviation enhances structural optimization methods, computer based design capability extended through substructure synthesis, and optimality criteria provides optimum design for a select class of structural problems. Integrated Force Method of Analysis Research Topics are boundary compatibility formulation improves stress analysis of shell structures. Brief descriptions of the four topics are appended.

  15. Optimisation explains global leaf trait patterns and plant adaptations to global change (Invited)

    NASA Astrophysics Data System (ADS)

    Dewar, R. C.; McMurtrie, R. E.

    2009-12-01

    Measured values of four key leaf traits (leaf area per unit mass, nitrogen concentration, photosynthetic rate and leaf lifespan) co-vary globally according to relationships that hold across all the world’s terrestrial plants. The same leaf traits respond consistently to altered environmental conditions (e.g. light intensity, carbon dioxide concentration and nitrogen supply). Explaining observed global leaf trait patterns and leaf responses to environmental change is a prerequisite to understanding and predicting vegetation responses to global change more generally across a range of time scales. Recently [1] we have shown, using a simple model of plant carbon-nitrogen economy, that all of these leaf trait patterns and responses are consistent with an optimisation hypothesis that cumulative carbon export from leaves over their lifespan is maximised. Various closely-related optimisation hypotheses also explain other plant adaptations to environmental change, such as stomatal responses and altered patterns of growth allocation [2]. Incorporating plant optimisation into large scale vegetation-atmosphere models would ensure they are consistent with global leaf trait relationships, and would improve predictions of vegetation responses to global change. The challenge, both scientific and operational, is to do this consistently over a wide range of time scales. This talk will review our recent work using plant optimisation models [1,2] and highlight the potential of Maximum Entropy Production as a unifying optimisation principle for plant and ecosystem function across different time scales [3]. [1] McMurtrie RE, Dewar RC. 2009. Global variation of leaf traits explained from an hypothesis of optimal plant function. Manuscript in preparation. [2] Dewar RC, Franklin O, Makela A, McMurtrie RE, Valentine HT. 2009. Optimal function explains forest responses to global change. BioScience 59:127-139. [3] Dewar RC. 2009. Maximum entropy production and plants. Submitted to Phil

  16. Global space fusion energy

    NASA Astrophysics Data System (ADS)

    Latyshev, L. A.; Semashko, N. N.

    The possibility of meeting future global energy demands by producing energy in space is addressed. Comparisons are made between the parameters of space plants producing solar electric power, nuclear electric power, and thermonuclear electric power.

  17. Global warming elucidated

    SciTech Connect

    Shen, S.

    1995-03-01

    The meaning of global warming and its relevance to everyday life is explained. Simple thermodynamics is used to predict an oscillatory nature of the change in climate due to global warming. Global warming causes extreme events and bad weather in the near term. In the long term it may cause the earth to transition to another equilibrium state through many oscillation in climatic patterns. The magnitudes of these oscillations could easily exceed the difference between the end points. The author further explains why many no longer fully understands the nature and magnitudes of common phenomena such as storms and wind speeds because of these oscillations, and the absorptive properties of clouds. The author links the increase in duration of the El Nino to global warming, and further predicts public health risks as the earth transitions to another equilibrium state in its young history.

  18. Commitment to Global Education.

    ERIC Educational Resources Information Center

    Kennedy, Zita M.

    1983-01-01

    The need for a global education approach is emphasized in a teacher's account of a class that included 15 acoustically handicapped students. Topics focused on historical backgrounds and commonalities, food shortages, multinational corporations, and energy problems. (CL)

  19. The global carbon cycle

    SciTech Connect

    Sedjo, R.A. )

    1990-10-01

    The author discusses the global carbon cycle and cites the results of several recently completed research projects, that seem to indicate that the temperate zone forests are a sink for carbon rather than a source, as was previously believed.

  20. Global Health and Aging

    MedlinePlus

    ... everyday functioning in countries at different stages of economic development and with varying resources. Global efforts are required ... cross-national assessment conducted by the Organization for Economic Cooperation and Development (OECD) estimated that dementia affected about 10 million ...

  1. Global health surveillance.

    PubMed

    St Louis, Michael

    2012-07-27

    Awareness of the importance of global health surveillance increased in the latter part of the 20th century with the global emergence of human immunodeficiency virus and novel strains of influenza. In the first decade of the 21st century, several events further highlighted global shared interests in and vulnerability to infectious diseases. Bioterrorist use of anthrax spores in 2001 raised awareness of the value of public health surveillance for national security. The epidemic of severe acute respiratory syndrome (SARS) in 2003, re-emergence of a panzootic of avian influenza A H5N1 in 2005, and the sudden emergence of pandemic H1N1 in North America in 2009 all highlighted the importance of shared global responsibility for surveillance and disease control. In particular, in 2003, SARS precipitated changes in awareness of the world's collective economic vulnerability to epidemic shocks. PMID:22832992

  2. Technology and Global Change

    NASA Astrophysics Data System (ADS)

    Grübler, Arnulf

    2003-10-01

    Technology and Global Change describes how technology has shaped society and the environment over the last 200 years. Technology has led us from the farm to the factory to the internet, and its impacts are now global. Technology has eliminated many problems, but has added many others (ranging from urban smog to the ozone hole to global warming). This book is the first to give a comprehensive description of the causes and impacts of technological change and how they relate to global environmental change. Written for specialists and nonspecialists alike, it will be useful for researchers and professors, as a textbook for graduate students, for people engaged in long-term policy planning in industry (strategic planning departments) and government (R & D and technology ministries, environment ministries), for environmental activists (NGOs), and for the wider public interested in history, technology, or environmental issues.

  3. The Global Menace

    PubMed Central

    Hodges, Sarah

    2015-01-01

    Summary The history of medicine has gone ‘global.’ Why? Can the proliferation of the ‘global’ in our writing be explained away as a product of staying true to our historical subjects’ categories? Or has this historiography in fact delivered a new ‘global’ problematic or performed serious ‘global’ analytic work? The situation is far from clear, and it is the tension between the global as descriptor and an analytics of the global that concerns me here. I have three main concerns: (1) that there is an epistemic collusion between the discourses of universality that inform medical science and global-talk; (2) that the embrace of the ‘global’ authorises a turning away from analyses of power in history-writing in that (3) this turning away from analyses of power in history-writing leads to scholarship that reproduces rather than critiques globalisation as a set of institutions, discourses and practices. PMID:26345469

  4. Monitoring global snow cover

    NASA Technical Reports Server (NTRS)

    Armstrong, Richard; Hardman, Molly

    1991-01-01

    A snow model that supports the daily, operational analysis of global snow depth and age has been developed. It provides improved spatial interpolation of surface reports by incorporating digital elevation data, and by the application of regionalized variables (kriging) through the use of a global snow depth climatology. Where surface observations are inadequate, the model applies satellite remote sensing. Techniques for extrapolation into data-void mountain areas and a procedure to compute snow melt are also contained in the model.

  5. Update on global immunization.

    PubMed

    Weber, Carol J

    2007-10-01

    The international community recognizes that investing in the health development of poor and disadvantaged countries is central to reducing poverty. Immunization is one strategy in the global effort to reduce infant mortality, improve maternal health, and combat infectious disease. In this day of global interdependence, all countries are vulnerable to uncontrolled spread of disease through epidemics. Achieving the Millennium Development Goals will not only help developing countries, but it will also contribute to improving health and security for all. PMID:17990623

  6. Promoting Global Health

    PubMed Central

    Winker, Margaret A.; Ferris, Lorraine E.

    2015-01-01

    The Editor-in-Chief of the International Journal of MCH and AIDS (IJMA) is a member of the World Association of Medical Editors (WAME). The Editorial Board of IJMA believes it is important that the statement on promoting global health and this accompanying editorial is brought to the attention of our readers. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

  7. Global climatic catastrophes

    SciTech Connect

    Budyko, M.I.; Golitsyn, G.S.; Izrael, A

    1988-01-01

    This work inquires into global climatic catastrophes of the past, presenting data not easily available outside of the Socialist Countries, and applies these results to the study of future climatic developments, especially as they threaten in case of Nuclear Warfare - Nuclear Winter. The authors discuss probable after effects from the Soviet point of view on the basis of research, stressing the need to avoid all conflict which might lead to the next and final Global Climatic Catastrophy.

  8. Global warming, bad weather, insurance losses and the global economy

    SciTech Connect

    Low, N.C.; Shen, S.

    1996-09-01

    Global warming causes extremely bad weather in the near term. The impact on the insurance industry is described. Why global warming in the near term causes very bad weather is explained. The continuing trend of very bad weather and the future impact on the insurance industry is explored. How very bad weather can affect the global financial market is explained. Taking a historical view of the development of the modern economy, the authors describe in the near term the impact of global warming on the global economy. The long term impact of global warming on the global economy and the human race is explored. Opportunities presented by global warming are described.

  9. Tabu optimization for matched field inversion

    NASA Astrophysics Data System (ADS)

    Michalopoulou, Zoi-Heleni; Ghosh-Dastidar, Urmi

    2002-11-01

    Matched field processing is a powerful tool for source localization and geoacoustic inversion. Because of significant environmental and geometry uncertainties, however, matched field processing usually involves multiparameter searches. To facilitate these searches, global optimization techniques such as genetic algorithms and simulated annealing have been successfully employed. In this work, a different approach, tabu, is implemented for optimization in matched field inversion. Tabu is a technique relying on the use of memory; it searches for the global maximum of the objective function through a navigation process that avoids already revisited models, also making use of aspiration criteria and diversification for faster convergence. The tabu performance in localization and geoacoustic inversion is demonstrated through experimentation with both synthetic and real (SWellEX 96) data. The approach is shown to provide reliable estimates in an efficient manner. [Work supported by ONR.

  10. Stochastic Optimal Control via Bellman's Principle

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Sun, Jian Q.

    2003-01-01

    This paper presents a method for finding optimal controls of nonlinear systems subject to random excitations. The method is capable to generate global control solutions when state and control constraints are present. The solution is global in the sense that controls for all initial conditions in a region of the state space are obtained. The approach is based on Bellman's Principle of optimality, the Gaussian closure and the Short-time Gaussian approximation. Examples include a system with a state-dependent diffusion term, a system in which the infinite hierarchy of moment equations cannot be analytically closed, and an impact system with a elastic boundary. The uncontrolled and controlled dynamics are studied by creating a Markov chain with a control dependent transition probability matrix via the Generalized Cell Mapping method. In this fashion, both the transient and stationary controlled responses are evaluated. The results show excellent control performances.

  11. Is Global Warming Accelerating?

    NASA Astrophysics Data System (ADS)

    Shukla, J.; Delsole, T. M.; Tippett, M. K.

    2009-12-01

    A global pattern that fluctuates naturally on decadal time scales is identified in climate simulations and observations. This newly discovered component, called the Global Multidecadal Oscillation (GMO), is related to the Atlantic Meridional Oscillation and shown to account for a substantial fraction of decadal fluctuations in the observed global average sea surface temperature. IPCC-class climate models generally underestimate the variance of the GMO, and hence underestimate the decadal fluctuations due to this component of natural variability. Decomposing observed sea surface temperature into a component due to anthropogenic and natural radiative forcing plus the GMO, reveals that most multidecadal fluctuations in the observed global average sea surface temperature can be accounted for by these two components alone. The fact that the GMO varies naturally on multidecadal time scales implies that it can be predicted with some skill on decadal time scales, which provides a scientific rationale for decadal predictions. Furthermore, the GMO is shown to account for about half of the warming in the last 25 years and hence a substantial fraction of the recent acceleration in the rate of increase in global average sea surface temperature. Nevertheless, in terms of the global average “well-observed” sea surface temperature, the GMO can account for only about 0.1° C in transient, decadal-scale fluctuations, not the century-long 1° C warming that has been observed during the twentieth century.

  12. Globalization and Science Education

    NASA Astrophysics Data System (ADS)

    Bencze, J. Lawrence; Carter, Lyn; Chiu, Mei-Hung; Duit, Reinders; Martin, Sonya; Siry, Christina; Krajcik, Joseph; Shin, Namsoo; Choi, Kyunghee; Lee, Hyunju; Kim, Sung-Won

    2013-06-01

    Processes of globalization have played a major role in economic and cultural change worldwide. More recently, there is a growing literature on rethinking science education research and development from the perspective of globalization. This paper provides a critical overview of the state and future development of science education research from the perspective of globalization. Two facets are given major attention. First, the further development of science education as an international research domain is critically analyzed. It seems that there is a predominance of researchers stemming from countries in which English is the native language or at least a major working language. Second, the significance of rethinking the currently dominant variants of science instruction from the perspectives of economic and cultural globalization is given major attention. On the one hand, it is argued that processes concerning globalization of science education as a research domain need to take into account the richness of the different cultures of science education around the world. At the same time, it is essential to develop ways of science instruction that make students aware of the various advantages, challenges and problems of international economic and cultural globalization.

  13. Globalization and Science Education

    NASA Astrophysics Data System (ADS)

    Bencze, J. Lawrence; Carter, Lyn; Chiu, Mei-Hung; Duit, Reinders; Martin, Sonya; Siry, Christina; Krajcik, Joseph; Shin, Namsoo; Choi, Kyunghee; Lee, Hyunju; Kim, Sung-Won

    2012-12-01

    Processes of globalization have played a major role in economic and cultural change worldwide. More recently, there is a growing literature on rethinking science education research and development from the perspective of globalization. This paper provides a critical overview of the state and future development of science education research from the perspective of globalization. Two facets are given major attention. First, the further development of science education as an international research domain is critically analyzed. It seems that there is a predominance of researchers stemming from countries in which English is the native language or at least a major working language. Second, the significance of rethinking the currently dominant variants of science instruction from the perspectives of economic and cultural globalization is given major attention. On the one hand, it is argued that processes concerning globalization of science education as a research domain need to take into account the richness of the different cultures of science education around the world. At the same time, it is essential to develop ways of science instruction that make students aware of the various advantages, challenges and problems of international economic and cultural globalization.

  14. Global challenges and globalization of bioethics

    PubMed Central

    Nezhmetdinova, Farida

    2013-01-01

    This article analyzes problems and implications for man and nature connected with the formation of a new architecture of science, based on the convergence of nanotechnology, biotechnology, information technology, and cognitive science (NBIC). It also describes evolution and genesis of bioethics, a scientific discipline and social practice with a special role of ethical management of potential risks of scientific research. The aim was to demonstrate the necessity of bioethical social control in the development of a global bioeconomy driven by NBIC technologies. PMID:23447421

  15. Global challenges and globalization of bioethics.

    PubMed

    Nezhmetdinova, Farida

    2013-02-01

    This article analyzes problems and implications for man and nature connected with the formation of a new architecture of science, based on the convergence of nanotechnology, biotechnology, information technology, and cognitive science (NBIC). It also describes evolution and genesis of bioethics, a scientific discipline and social practice with a special role of ethical management of potential risks of scientific research. The aim was to demonstrate the necessity of bioethical social control in the development of a global bioeconomy driven by NBIC technologies. PMID:23447421

  16. Analog Processor To Solve Optimization Problems

    NASA Technical Reports Server (NTRS)

    Duong, Tuan A.; Eberhardt, Silvio P.; Thakoor, Anil P.

    1993-01-01

    Proposed analog processor solves "traveling-salesman" problem, considered paradigm of global-optimization problems involving routing or allocation of resources. Includes electronic neural network and auxiliary circuitry based partly on concepts described in "Neural-Network Processor Would Allocate Resources" (NPO-17781) and "Neural Network Solves 'Traveling-Salesman' Problem" (NPO-17807). Processor based on highly parallel computing solves problem in significantly less time.

  17. Defining a fire year for reporting and analysis of global interannual fire variability

    NASA Astrophysics Data System (ADS)

    Boschetti, Luigi; Roy, David P.

    2008-09-01

    The interannual variability of fire activity has been studied without an explicit investigation of a suitable starting month for yearly calculations. Sensitivity analysis of 37 months of global MODIS active fire detections indicates that a 1-month change in the start of the fire year definition can lead, in the worst case, to a difference of over 6% and over 45% in global and subcontinental scale annual fire totals, respectively. Optimal starting months for analyses of global and subcontinental fire interannual variability are described. The research indicates that a fire year starting in March provides an optimal definition for annual global fire activity.

  18. Cyclone performance and optimization

    SciTech Connect

    Leith, D.

    1990-12-15

    An empirical model for predicting pressure drop across a cyclone, developed by Dirgo (1988), is presented. The model was developed through a statistical analysis of pressure drop data for 98 cyclone designs. This model is used with the efficiency model of Iozia and Leith (1990) to develop an optimization curve which predicts the minimum pressure drop on the dimension ratios of the optimized cyclone for a given aerodynamic cut diameter, d{sub 50}. The effect of variation in cyclone height, cyclone diameter, and flow on the optimization is determined. The optimization results are used to develop a design procedure for optimized cyclones. 33 refs., 10 figs., 4 tabs.

  19. Hope, optimism and delusion

    PubMed Central

    McGuire-Snieckus, Rebecca

    2014-01-01

    Optimism is generally accepted by psychiatrists, psychologists and other caring professionals as a feature of mental health. Interventions typically rely on cognitive-behavioural tools to encourage individuals to ‘stop negative thought cycles’ and to ‘challenge unhelpful thoughts’. However, evidence suggests that most individuals have persistent biases of optimism and that excessive optimism is not conducive to mental health. How helpful is it to facilitate optimism in individuals who are likely to exhibit biases of optimism already? By locating the cause of distress at the individual level and ‘unhelpful’ cognitions, does this minimise wider systemic social and economic influences on mental health? PMID:25237497

  20. Global Urbanization Modeling Supported by Remote Sensing

    NASA Astrophysics Data System (ADS)

    Zhou, Y.; Smith, S.; Zhao, K.; Imhoff, M. L.; Thomson, A. M.; Bond-Lamberty, B. P.; Elvidge, C.

    2014-12-01

    Urbanization, one of the major human induced land cover and land use change, has profound impacts on the Earth system, and plays important roles in a variety of processes such as biodiversity loss, water and carbon cycle, and climate change. Accurate information on urban areas and their spatial distribution at the regional and global scales is important in both scientific and policy-making communities. The Defense Meteorological Satellite Program/Operational Linescan System (DMSP/OLS) nighttime stable light data (NTL) provide a potential way to map urban area and its dynamics economically and timely. In this study, we developed a cluster-based method to estimate the optimal thresholds and map urban extents from the DMSP/OLS NTL data. The sensitivity analysis demonstrates the robustness of the derived optimal thresholds and the reliability of the cluster-based method. Compared to existing threshold techniques, our method reduces the over- and under-estimation issue, when mapping urban extent over a large area. Using this cluster-based method, we built new global maps of 1-km urban extent from the NTL data (Figure 1) and evaluated its temporal dynamics from 1992 to 2013. Supported by the derived global urban maps and socio-economic drivers, we developed an integrated modeling framework by integrating a top-down macro-scale statistical model with a bottom-up urban growth model and projected future urban expansion.