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Sample records for controversial sensitizer european

  1. Women's health issues cause controversy in European Union.

    PubMed

    Rogers, A

    1998-08-22

    Women's health issues will be raised in the European Parliament in September, when members return from vacation. Nel van Dijk, Dutch Green party deputy, produced a report to the plenary for the assembly's Committee on Women's Rights; in the report, committee members urge action by the European Union (EU) and list recommendations for member-state governments. The report is in response to a publication by the European Commission, in May 1997, of a statistical survey developed from national data. The resolution by van Dijk urges EU-wide legalization of abortion in certain circumstances based on the final decision of the woman involved. In a motion for resolution by the Parliament, the committee was concerned that the Commission had dealt only summarily with the different situations regarding abortion in the member states and that it had not dealt with backstreet abortions. Originally, the report was slated for a session when attendance was poor, the closing Friday session before the July plenary's closing. Sufficient support was mustered from the floor of the assembly to move the report to an earlier point on the agenda; however, those opposed to the report managed to send it back to committee. Currently, the EU is acting on limited powers conferred by the 1992 Maastricht Treaty with regard to coordination of health policy in EU states. The van Dijk report details demands regarding EU research, information programs, and other initiatives concerning tampon-related toxic shock syndrome, osteoporosis, breast and cervical cancer, depression, hormonal treatments, female genital mutilation, and eating disorders. Sexual harassment and violence against women are also included; these are not covered by the Treaty. The report may be stalled indefinitely due to legislative business ahead of the June 1999 Euro-elections. PMID:9746038

  2. Salt Sensitivity: Challenging and Controversial Phenotype of Primary Hypertension.

    PubMed

    Iatrino, Rossella; Manunta, Paolo; Zagato, Laura

    2016-09-01

    Increases in life expectancy and cardiovascular adverse events in patients with hypertension highlight the need for new risk-reduction strategies to reduce the burden of degenerative diseases. Among the environmental factors, high salt consumption is currently considered the most important risk factor of hypertension. However, while high salt intake significantly raises blood pressure in some individuals, others do not show variation or even decrease their blood pressure. This heterogeneity is respectively classified as salt sensitivity and salt resistance. In this review, we propose salt sensitivity as a useful phenotype to unravel the mechanistic complexity of primary hypertension. The individual variability in blood pressure modification in response to salt intake changes derives from the combination of genetic and environmental determinants. This combination of random and non random determinants leads to the development of a personal index of sensitivity to salt. However, those genes involved in susceptibility to salt are still not completely identified, and the triggering mechanisms underlying the following development of hypertension still remain uncovered. One reason might be represented by the absence of a specific protocol, universally followed, for a standard definition of salt sensitivity. Another reason may be linked to the absence of common criteria for patient recruitment during clinical studies. Thus, the generation of a reliable approach for a proper recognition of this personal index of sensitivity to salt, and through it the identification of novel therapeutic targets for primary hypertension, should be one of the aspirations for the scientific community. PMID:27614755

  3. Sensitive and Controversial Issues in the Classroom: Teaching History in a Divided Society

    ERIC Educational Resources Information Center

    Kello, Katrin

    2016-01-01

    Teaching sensitive and controversial issues (SCIs) is of growing interest in contemporary, increasingly heterogeneous societies. In democracies, different groups and institutions expect their values and worldviews to be conveyed at school. On one hand, there is the expectation that SCIs should be treated neutrally. On the other hand, there are…

  4. Controversial issues in hyperbaric oxygen therapy: a European Committee for Hyperbaric Medicine Workshop.

    PubMed

    Kot, Jacek; Mathieu, Daniel

    2011-06-01

    Every few years, the European Committee for Hyperbaric Medicine (ECHM) publishes its recommendations concerning the clinical indications for hyperbaric oxygen therapy (HBOT). The last recommendations were issued during the 7th European Consensus Conference on Hyperbaric Medicine in 2004. Since then, several publications have reported on the use of HBOT in some indications in which it has not yet been recommended routinely, namely aseptic bone necrosis, global brain ischaemia and autism. Patients or their families push physicians and staff of hyperbaric facilities to use hyperbaric treatment regardless of the quality of the scientific evidence. Therefore, the ECHM Workshop "Controversial issues in hyperbaric oxygen therapy" was convened as a satellite meeting of the 2010 European Underwater and Baromedical Society Annual Scientific Meeting in Istanbul, Turkey in 2010. For each topic, a set procedure was used: first came a general report by specialists in the topic, incorporating a review of current pathophysiological, experimental and clinical evidence. Then, there were reports from hyperbaric facilities that had gained clinical experience in that condition, followed by a general discussion with specialists present in the audience. Finally, statements regarding each topic were proposed and voted on by the audience and these were presented to the ECHM Executive Board for consideration and possible approval. In conclusion, the use of HBOT in femoral head necrosis will be proposed during the next ECHM Consensus Conference to become an 'accepted' indication; whilst the use of HBOT in global brain ischaemia and autism should retain its current ECHM recommendations, that it should be 'optional' and 'non-accepted' respectively. PMID:21848114

  5. Unveiling a Role for the EU? The "Headscarf Controversy" in European Schools

    ERIC Educational Resources Information Center

    Smith, Rhona K. M.

    2007-01-01

    Many European countries have introduced laws and policies which proscribe religious clothing in public educational institutions. The European Convention on Human Rights has been deployed to uphold such actions, the European Court of Human Rights recognising that States should be able to limit the manifestation of religious beliefs. National courts…

  6. Teaching Controversy without Controversy

    ERIC Educational Resources Information Center

    Stiehm, Judith

    1976-01-01

    Discussion of "Sex, Power, and Politics" course at the University of Southern California in which the videotaping of class sessions is used to reduce classroom controversy while studying controversy. (ND)

  7. SENSITIVITY TRAINING, A REVIEW OF THE CONTROVERSY--KEY ISSUES SERIES, NUMBER 1.

    ERIC Educational Resources Information Center

    COGHILL, MARY ANN

    DISTINCTIONS BETWEEN LABORATORY TRAINING, T-GROUP TRAINING, AND SENSITIVITY TRAINING ARE MADE, FOLLOWED BY A DIARY OF A T-GROUP IN SESSION. THE BACKGROUND AND DEVELOPMENT OF THE LABORATORY APPROACH IS PRESENTED, HIGHLIGHTING THOSE ASPECTS, PROBLEMS, AND RESULTS WHICH ARE OF GREATEST INTEREST TO INDUSTRIAL AND LABOR RELATIONS. A DISCUSSION OF THE…

  8. [Non-allergic gluten sensitivity. A controversial disease - or not yet sufficiently explored?].

    PubMed

    Raithel, Martin; Kluger, Anna Katharina; Dietz, Birgit; Hetterich, Urban

    2016-07-01

    The avoidance of wheat, gluten and other cereal products is a growing phenomenon in industrialized countries. The diagnostic criteria of celiac disease and of food allergy to wheat flour and/or other cereals are clearly defined. Only about 0.5-25 % of the population are affected from both of these immunological diseases.Nevertheless, there exists a significantly greater proportion of people reporting at least subjectively significant complaints and quality of life improvements after switching to a wheat- or gluten-free diet. Celiac disease or wheat allergy cannot be detected in these individuals on the basis of established criteria. The absence of clear diagnostic autoimmune or allergic criteria in these wheat sensitive patients has resulted in the description of non-celiac gluten sensitivity.It is clinically detectable in only very few individuals and may manifest with either intestinal, extra-intestinal or neurovegetative and psychosomatic symptoms, respectively. However, non-celiac disease gluten sensitivity has to be differentiated critically from irritable bowel syndrome, carbohydrate malassimilation, postinfectious conditions and psychosomatic diseases.Pathophysiologically, non-celiac disease gluten sensitivity is still poorly characterized; several non-immunological mechanisms are discussed to contribute to non-celiac gluten sensitivity. These include the effects of fructo- and galacto-oligosaccharides, of trypsin inhibitors of amylase, and wheat lectin agglutinins, which may influence or modulate intestinal permeability and/or a non-specific immune or effector cell degranulation within the gastrointestinal tract. In addition, further metabolic effects with direct or indirect influence on the intestinal flora are currently discussed.In addition to subjectively reported changes in symptoms that may affect variably intestinal, as well as extra-intestinal and/or neuropsychiatric symptoms, some studies suggest that there is little reproducibility of

  9. [Conditions, controversies and contradictions between Central Sensitivity Syndrome and Depressive Disorders].

    PubMed

    Maresca, Tomás; Covini, Elvira; Mato, Andrea Márquez López

    2013-01-01

    We present a description of the Central Sensitivity Syndrome (CSS) and some of its main components such as Multiple Chemical Sensitivity Syndrome, Chronic Fatigue Syndrome and Fibromyalgia. We review the changes in pain perception, describing the physiology and pathophysiology of the painful experience from the medulla horn to the CNS. We explain the theory of central sensitization as the basis to the syndrome. We refer to the differences between fibromyalgia and depressive disorders, is spite of their frequent presentation in comorbidity. We state the main clinical and neurobiological differences. We point out the main psychoneuroimmunoendocrinologic differences such as adrenal activity (hypoactivity vs. hyperactivity, DST hypersuppressive response vs. DST non suppression, hypersensitivity of central glucocorticoid receptors vs. desensitization of these, among others), thyroid (probable reverse T3 vs. flat stimuli TSH response curve) and growth hormone secretion (probable increase vs. disruption of normal circadian rhythm) that makes CSS resemble PTSD. We describe differential changes in sleep patterns (alpha-delta intrusion vs. altered sleep time, REM latency, and stage 3/4) and immunological disturbances almost opposite in each pathological entity. We finally argue which medical specialty should treat these complex syndromes. PMID:24312923

  10. Ground-Based Optical Measurements at European Flux Sites: A Review of Methods, Instruments and Current Controversies

    PubMed Central

    Balzarolo, Manuela; Anderson, Karen; Nichol, Caroline; Rossini, Micol; Vescovo, Loris; Arriga, Nicola; Wohlfahrt, Georg; Calvet, Jean-Christophe; Carrara, Arnaud; Cerasoli, Sofia; Cogliati, Sergio; Daumard, Fabrice; Eklundh, Lars; Elbers, Jan A.; Evrendilek, Fatih; Handcock, Rebecca N.; Kaduk, Joerg; Klumpp, Katja; Longdoz, Bernard; Matteucci, Giorgio; Meroni, Michele; Montagnani, Lenoardo; Ourcival, Jean-Marc; Sánchez-Cañete, Enrique P.; Pontailler, Jean-Yves; Juszczak, Radoslaw; Scholes, Bob; Martín, M. Pilar

    2011-01-01

    This paper reviews the currently available optical sensors, their limitations and opportunities for deployment at Eddy Covariance (EC) sites in Europe. This review is based on the results obtained from an online survey designed and disseminated by the Co-cooperation in Science and Technology (COST) Action ESO903—“Spectral Sampling Tools for Vegetation Biophysical Parameters and Flux Measurements in Europe” that provided a complete view on spectral sampling activities carried out within the different research teams in European countries. The results have highlighted that a wide variety of optical sensors are in use at flux sites across Europe, and responses further demonstrated that users were not always fully aware of the key issues underpinning repeatability and the reproducibility of their spectral measurements. The key findings of this survey point towards the need for greater awareness of the need for standardisation and development of a common protocol of optical sampling at the European EC sites. PMID:22164055

  11. Interfacing of Science, Medicine and Law: The Stem Cell Patent Controversy in the United States and the European Union.

    PubMed

    Davey, Sonya; Davey, Neil; Gu, Qian; Xu, Na; Vatsa, Rajet; Devalaraja, Samir; Harris, Paul; Gannavaram, Sreenivas; Dave, Raj; Chakrabarty, Ananda

    2015-01-01

    The patent eligibility of stem cells-particularly those derived from human embryos-has long been under debate in both the scientific and legal communities. On the basis of moral grounds, the European Patent Office (EPO) has refrained from granting patents for stem cells obtained through the destruction of human embryos. On the contrary, the United States Patent and Trademark Office (USPTO) has historically granted patents regarding the isolation and use of human embryonic and other stem cells. To date, these US patents remain valid despite an increasing onslaught of challenges in court. However, recent precedents established in US courts significantly narrow the scope of patent eligibility within biotechnology. This article compares the implications of recent legal changes on stem cell patent eligibility between the EU and US. PMID:26618158

  12. Interfacing of Science, Medicine and Law: The Stem Cell Patent Controversy in the United States and the European Union

    PubMed Central

    Davey, Sonya; Davey, Neil; Gu, Qian; Xu, Na; Vatsa, Rajet; Devalaraja, Samir; Harris, Paul; Gannavaram, Sreenivas; Dave, Raj; Chakrabarty, Ananda

    2015-01-01

    The patent eligibility of stem cells–particularly those derived from human embryos–has long been under debate in both the scientific and legal communities. On the basis of moral grounds, the European Patent Office (EPO) has refrained from granting patents for stem cells obtained through the destruction of human embryos. On the contrary, the United States Patent and Trademark Office (USPTO) has historically granted patents regarding the isolation and use of human embryonic and other stem cells. To date, these US patents remain valid despite an increasing onslaught of challenges in court. However, recent precedents established in US courts significantly narrow the scope of patent eligibility within biotechnology. This article compares the implications of recent legal changes on stem cell patent eligibility between the EU and US. PMID:26618158

  13. Circumcision controversies.

    PubMed

    Pinto, Kirk

    2012-08-01

    Despite its long history and common practice, circumcision remains a controversial procedure. This article reviews the history of this operation, examines the controversy that surrounds it, and emphasizes the performing practitioner's responsibility to the patient and his family in guiding them through the complicated decision making surrounding newborn circumcision. PMID:22857844

  14. Plutonium controversy

    SciTech Connect

    Richmond, C.R.

    1980-01-01

    The toxicity of plutonium is discussed, particularly in relation to controversies surrounding the setting of radiation protection standards. The sources, amounts of, and exposure pathways of plutonium are given and the public risk estimated. (ACR)

  15. Controversy Corner.

    ERIC Educational Resources Information Center

    Morris, John O.

    1986-01-01

    Argues that business communication should encourage the use of plain language while breaking down the ideas that it is unprofessional to write in clear prose and that it is safer to keep prose muddy so as to avoid controversy in an organization. (SRT)

  16. Second St. Gallen European Organisation for Research and Treatment of Cancer Gastrointestinal Cancer Conference: consensus recommendations on controversial issues in the primary treatment of rectal cancer.

    PubMed

    Lutz, Manfred P; Zalcberg, John R; Glynne-Jones, Rob; Ruers, Theo; Ducreux, Michel; Arnold, Dirk; Aust, Daniela; Brown, Gina; Bujko, Krzysztof; Cunningham, Christopher; Evrard, Serge; Folprecht, Gunnar; Gerard, Jean-Pierre; Habr-Gama, Angelita; Haustermans, Karin; Holm, Torbjörn; Kuhlmann, Koert F; Lordick, Florian; Mentha, Gilles; Moehler, Markus; Nagtegaal, Iris D; Pigazzi, Alessio; Puciarelli, Salvatore; Roth, Arnaud; Rutten, Harm; Schmoll, Hans-Joachim; Sorbye, Halfdan; Van Cutsem, Eric; Weitz, Jürgen; Otto, Florian

    2016-08-01

    Primary treatment of rectal cancer was the focus of the second St. Gallen European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Cancer Conference. In the context of the conference, a multidisciplinary international expert panel discussed and voted on controversial issues which could not be easily answered using published evidence. Main topics included optimal pretherapeutic imaging, indication and type of neoadjuvant treatment, and the treatment strategies in advanced tumours. Here we report the key recommendations and summarise the related evidence. The treatment strategy for localised rectal cancer varies from local excision in early tumours to neoadjuvant radiochemotherapy (RCT) in combination with extended surgery in locally advanced disease. Optimal pretherapeutic staging is a key to any treatment decision. The panel recommended magnetic resonance imaging (MRI) or MRI + endoscopic ultrasonography (EUS) as mandatory staging modalities, except for early T1 cancers with an option for local excision, where EUS in addition to MRI was considered to be most important because of its superior near-field resolution. Primary surgery with total mesorectal excision was recommended by most panellists for some early tumours with limited risk of recurrence (i.e. cT1-2 or cT3a N0 with clear mesorectal fascia on MRI and clearly above the levator muscles), whereas all other stages were considered for multimodal treatment. The consensus panel recommended long-course RCT over short-course radiotherapy for most clinical situations where neoadjuvant treatment is indicated, with the exception of T3a/b N0 tumours where short-course radiotherapy or even no neoadjuvant therapy were regarded to be an option. In patients with potentially resectable tumours and synchronous liver metastases, most panel members did not see an indication to start with classical fluoropyrimidine-based RCT but rather favoured preoperative short-course radiotherapy with systemic

  17. Facelift Controversies.

    PubMed

    Barrett, Dane M; Gerecci, Deniz; Wang, Tom D

    2016-08-01

    The primary purpose of the facelift is to restore the shape, volume, and contours of the youthful face. Facelift surgery has evolved over the years into multiple techniques to accomplish the same results. This article discusses the common controversies in facelift surgery and evaluates the best available evidence to guide surgical decision-making. In regard to the salient question of whether there is a "best" technique, the literature suggests that the options are generally equal in efficacy. This highlights the need for high-quality research with standardized preoperative assessment and evaluation of postoperative results to better assess outcomes. PMID:27400849

  18. Controversial therapies.

    PubMed

    Silver, L B

    1995-01-01

    Parents of children or adolescents with disabilities want the best treatment. They are vulnerable to any person who reports having a quick solution and possibly a cure. It is important that professionals be informed of these controversial therapies so that they can educate parents on what is known about these treatments. There is a relationship between brain function and nutrition, as well as between brain function and allergic reactions. These relations appear to be true for children with learning disabilities, attention deficit hyperactivity disorder, and other neurologic disorders. At this time, however, we do not understand these relationships and there are no known treatments based on these relationships that have been shown to be clinically successful. Professionals must educate parents on proposed new treatments. Parents need to ask themselves why this amazing approach is not used by everyone. If the person proposing the treatment tells them that "most professionals are biased and do not believe the findings because they are different from the traditional treatments," they should feel free to ask to see the data supporting the concept and the treatment. They should not accept without question popular books published by the person proposing the treatment or information provided in a flyer or on a television show by the person proposing the treatment. They should not put their son or daughter through something unproved and unlikely to help. PMID:7751563

  19. "Mysticism" in Quantum Mechanics: The Forgotten Controversy

    ERIC Educational Resources Information Center

    Marin, Juan Miguel

    2009-01-01

    This paper argues that a European controversy over a "mystical" hypothesis, one assigning the mind a role to play at the material level of reality, shaped much of the debate over the interpretation of the quantum equations. It traces back the controversy to the past two decades, beginning in the late 1920s--birth of quantum theory--and concluding…

  20. Responsibility-sensitive fairness in health financing: judgments in four European countries.

    PubMed

    Le Clainche, Christine; Wittwer, Jerome

    2015-04-01

    Risky health behaviours substantially increase medical and social costs. We document the extent to which a sample of European students (from Denmark, France, Italy and Sweden) consider that individuals should assume the financial burden of paying the costs of risky behaviour. We test the acceptability of different ways of financing costs because of ill health that is more or less associated with risky behaviour in accordance with a normative framework relating to responsibility-sensitive fairness. We find that the majority of students agree with assuming financial responsibility for risky behaviours and that there should be compensation for unfavourable circumstances. Students agree that two individuals with the same responsibility variables should make an equal financial contribution and that more effort in maintaining health for given circumstances should be rewarded with a lower financial contribution. The specific health context and the type of risky behaviours involved matter in determining perceptions of justice in health financing. PMID:24577735

  1. Interdependencies between temperature and moisture sensitivities of CO2 emissions in European land ecosystems

    NASA Astrophysics Data System (ADS)

    Gritsch, C.; Zimmermann, M.; Zechmeister-Boltenstern, S.

    2015-10-01

    Soil respiration is one of the largest terrestrial fluxes of carbon dioxide (CO2) to the atmosphere. Hence, small changes in soil respiration rates could have large effects on atmospheric CO2. In order to assess CO2 emissions from diverse European soils with different land-use types and climate (soil moisture and temperature), we conducted a laboratory incubation experiment. Emission measurements of CO2 under controlled conditions were conducted using soil monoliths of nine sites from a European flux network (ÉCLAIRE). The sites are located all over Europe - from the United Kingdom in the west to Ukraine in the east, and from Italy in the south to Finland in the north - and can be separated according to four land-use types (forests, grasslands, arable lands and one peatland). Intact soil cores were incubated in the laboratory in a two-way factorial design, with temperature (5, 10, 15, 20 and 25 °C) and water-filled pore space (WFPS; 5, 20, 40, 60 and 80 %) as the independent variables, while CO2 flux was the response variable. The latter was measured with an automated laboratory incubation measurement system. Land use generally had a substantial influence on carbon dioxide fluxes, with the order of CO2 emission rates of the different land-use types being grassland > peatland > forest/arable land (P < 0.001). CO2 efflux responded strongly to varying temperature and moisture content with optimum moisture contents for CO2 emissions between 40 and 70 % WFPS and a positive relationship between CO2 emissions and temperature. The relationship between temperature and CO2 emissions could be well described by a Gaussian model. Q10 values ranged between 0.86 and 10.85 and were negatively related to temperature for most of the moisture contents and sites investigated. At higher temperatures the effect of water and temperature on Q10 was very low. In addition, under cold temperatures Q10 varied with moisture contents, indicating a stronger prospective effect of rain events in

  2. The sensitivity of the northwest European continental shelf ecosystem to anthropogenic pressures

    NASA Astrophysics Data System (ADS)

    Wakelin, Sarah; Artioli, Yuri; Holt, Jason; Butenschön, Momme

    2013-04-01

    Anthropogenic pressure is exerted on ecosystems in several ways, through direct drivers such as eutrophication and levels of fishing effort and by changes in the physical environment brought about by climate change. Changes in water temperature, the timing and duration of seasonal stratification, circulation patterns and ocean-shelf exchange all impact on shelf-sea primary production. We use a coupled hydrodynamics-ecosystem model (POLCOMS-ERSEM) to study ecosystem sensitivity to climate change and the anthropogenic drivers of river nutrient loads, impacting on eutrophication, and trawling effort on the northwest European continental shelf, with an emphasis on changes in the North Sea. To force the model we use data from a coupled ocean-atmosphere global model (IPSL-CM4) representative of conditions in the recent past (1983-2000) and possible conditions in the near future (2030-2040) under a business as usual emissions scenario SRES A1B. To study ecosystem sensitivity to direct anthropogenic forcing, we adopt two scenarios impacting on river nutrient loads and trawling effort - one where there is rapid economic growth and limited environmental policies and a second where economic growth is constrained by environmental objectives. The sensitivity of the system to each single driver: climate change, increase in river nutrient loads, decrease in river nutrient loads and reduction in trawling effort is explored. The response of the ecosystem to the combined effects of changes in multiple drivers under the two scenarios of economic growth is also studied. The results are relevant to the Marine Strategy Framework Directive descriptors on marine food webs, eutrophication and biodiversity.

  3. Interdependencies between temperature and moisture sensitivities of CO2 emissions in European land ecosystems

    NASA Astrophysics Data System (ADS)

    Gritsch, C.; Zimmermann, M.; Zechmeister-Boltenstern, S.

    2015-03-01

    Soil respiration is one of the largest terrestrial fluxes of carbon dioxide (CO2) to the atmosphere. Hence, small changes in soil respiration rates could have large effects on atmospheric CO2. In order to assess CO2 emissions from diverse European soils under different land-use and climate (soil moisture and temperature) we conducted a laboratory incubation experiment. Emission measurements of carbon dioxide under controlled conditions were conducted using soil monoliths of nine sites from the ÉCLAIRE flux network. Sites are located all over Europe; from the UK in the west to the Ukraine in the east; Italy in the south to Finland in the north and can be separated according to four land-uses (forests, grasslands, arable lands and one peatland). Intact soil cores were incubated in the laboratory at the temperatures 5, 10, 15, 20, and 25 °C in a two factorial design of five soil moisture levels (5, 20, 40, 60, 80 (100)% water filled pore space, WFPS), before analysed for CO2 fluxes with an automated laboratory incubation measurement system. Land-use generally had a substantial influence on carbon dioxide fluxes, with the order of CO2 emission rates of the different land-uses being grassland > peatland > forest/arable land (P < 0.001). CO2 efflux responded strongly to varying temperature and moisture content with optimum moisture contents for CO2 emissions between 40-70% WFPS and a positive relationship between CO2 emissions and temperature. The relationship between temperature and CO2 emissions could be well described by a Gaussian model. Q10 values ranged between 0.86-10.85 and were negatively related to temperature for most of the moisture contents and sites investigated. At higher temperatures the effect of water and temperature on Q10 was very low. In addition under cold temperatures Q10 varied with moisture contents indicating a stronger prospective effect of rain events in cold areas on temperature sensitivity. We found at both coniferous forest sites a strong

  4. Comparative sensitivity of European native (Anodonta anatina) and exotic (Corbicula fluminea) bivalves to mercury

    NASA Astrophysics Data System (ADS)

    Oliveira, Patrícia; Lopes-Lima, Manuel; Machado, Jorge; Guilhermino, Lúcia

    2015-12-01

    Pollution is believed to be an important factor modulating the competition between exotic invasive bivalves and their native competitors. Thus, the objective of the present study was to compare the sensitivity of the European native Anodonta anatina and the exotic invasive species Corbicula fluminea to mercury, a ubiquitous environmental contaminant of high concern. In laboratory acute bioassays, adult organisms of both species were exposed independently to mercury for 96 h (31-500 μg/L). The criteria indicative of toxicity were mortality and biomarkers of oxidative stress and damage, neurotoxicity, and energy production changes. Mercury induced mortality in A. anatina (72 h-LC10 and 72 h-LC50 of 14.0 μg/L and 49.6 μg/L, respectively) but not in C. fluminea. The ability of C. fluminea to maintaining the shell closed for considerable periods of time when exposed to high concentrations of mercury and the effective activation (up to 63 μg/L) of mechanisms against the oxidative stress caused by mercury may have contributed to its relatively low sensitivity. In the range of concentrations tested, mercury had no significant effects on the other parameters analysed in C. fluminea. Overall, the findings of the present study, suggest that in real scenarios of competition between C. fluminea and A. anatina populations, the presence of mercury may modulate the process, acting in favour of the exotic species because it is less sensitive to this environmental contaminant than the native bivalve. The results of the present study highlight the need of further investigation on the effects of mercury on the competition between exotic invasive species and their native competitors, especially the effects potentially induced by long-term exposure to low concentrations of this metal, the mechanisms involved in the tolerance to mercury-induced stress, and the potential post-exposure recovery of both exotic invasive and native bivalves. This knowledge is most important for

  5. Self-perceived weather sensitivity and joint pain in older people with osteoarthritis in six European countries: results from the European Project on OSteoArthritis (EPOSA)

    PubMed Central

    2014-01-01

    Background People with osteoarthritis (OA) frequently report that their joint pain is influenced by weather conditions. This study aimed to examine whether there are differences in perceived joint pain between older people with OA who reported to be weather-sensitive versus those who did not in six European countries with different climates and to identify characteristics of older persons with OA that are most predictive of perceived weather sensitivity. Methods Baseline data from the European Project on OSteoArthritis (EPOSA) were used. ACR classification criteria were used to determine OA. Participants with OA were asked about their perception of weather as influencing their pain. Using a two-week follow-up pain calendar, average self-reported joint pain was assessed (range: 0 (no pain)-10 (greatest pain intensity)). Linear regression analyses, logistic regression analyses and an independent t-test were used. Analyses were adjusted for several confounders. Results The majority of participants with OA (67.2%) perceived the weather as affecting their pain. Weather-sensitive participants reported more pain than non-weather-sensitive participants (M = 4.1, SD = 2.4 versus M = 3.1, SD = 2.4; p < 0.001). After adjusting for several confounding factors, the association between self-perceived weather sensitivity and joint pain remained present (B = 0.37, p = 0.03). Logistic regression analyses revealed that women and more anxious people were more likely to report weather sensitivity. Older people with OA from Southern Europe were more likely to indicate themselves as weather-sensitive persons than those from Northern Europe. Conclusions Weather (in)stability may have a greater impact on joint structures and pain perception in people from Southern Europe. The results emphasize the importance of considering weather sensitivity in daily life of older people with OA and may help to identify weather-sensitive older people with OA. PMID:24597710

  6. Managing Controversial Meetings.

    ERIC Educational Resources Information Center

    Marchiony, Eve

    The "management of crisis," as opposed to crisis management," requires prior planning. Boards of education that habitually practice courtesy and have some knowledge of group dynamics do not create controversy by their own actions and will have fewer controversial meetings to manage. Policymakers should know ahead of time what issues are likely to…

  7. Television's "Soap" Controversy.

    ERIC Educational Resources Information Center

    Stutzman, Brent

    The situation comedy, "Soap," television's first prime-time sex farce, stirred controversy months before its premiere, and subsequent pressure on advertisers forced the network to change the show's concept from an adult comedy to a "whodunit." This report summarizes the controversy, recounts reactions to the series, and lists the implications of…

  8. The molecular basis for the green-blue sensitivity shift in the rod visual pigments of the European eel.

    PubMed

    Archer, S; Hope, A; Partridge, J C

    1995-12-22

    When the European eel matures sexually and migrates back to deep sea breeding grounds the visual pigments in its rod photoreceptors change from being maximally sensitive to green light to being maximally sensitive to blue light. In part, this change in sensitivity is due to a change in the opsin component of the visual pigment molecule. We used hormone injection to induce these developmental changes in a group of eels and from these animals an opsin coding region was cloned and sequenced using cDNA made from retinal mRNA. From the retinae of hormone-injected eels and those not injected with hormones, distinct opsin mRNAs were isolated. These mRNAs encode two rod opsin proteins that are very similar but have significant amino acid substitutions in key positions that are likely to be involved in spectral tuning of the eel green and blue sensitive rod visual pigment molecules. PMID:8587887

  9. 'Mysticism' in quantum mechanics: the forgotten controversy

    NASA Astrophysics Data System (ADS)

    Marin, Juan Miguel

    2009-07-01

    This paper argues that a European controversy over a 'mystical' hypothesis, one assigning the mind a role to play at the material level of reality, shaped much of the debate over the interpretation of the quantum equations. It traces back the controversy to the past two decades, beginning in the late 1920s—birth of quantum theory—and concluding with Erwin Schrödinger's lectures published as 'Mind and Matter'. Becoming aware of the issues at stake can help us understand the historical, philosophical and cultural background from which today's physics emerged.

  10. The vibrating string controversy

    NASA Astrophysics Data System (ADS)

    Wheeler, Gerald F.; Crummett, William P.

    1987-01-01

    In the mid-1700s a debate raged between Jean d'Alembert, Leonhard Euler, and Daniel Bernoulli concerning the proper solution to the classical wave equation. This controversy was partially solved by Lagrange and, more conclusively, by Fourier (50 years later) and it provides an interesting case study for the role of mathematics in the modeling of physical phenomena. Of particular note in this debate, was the meaning of boundary conditions. The controversy is summarized from the point of view of this mathematical physics perspective.

  11. The Accountability Controversy

    ERIC Educational Resources Information Center

    Glisson, Charles

    1975-01-01

    Author discusses accountability controversy concerning effectiveness of social services. Turem's mechanistic and Gruber's organic models of accountability are compared and an alternate open system model of organization is offered which combines positive aspects of Turem's and Gruber's models as well as adds other constructive elements to them. (SE)

  12. The Choice Controversy.

    ERIC Educational Resources Information Center

    Cookson, Peter W., Jr., Ed.

    Issues in school choice--constitutionality, feasibility, equity, and educational productivity--are examined in this book. The controversy requires an ongoing analysis of the origins of the school-choice movement, the kinds of plans proposed and implemented, their educational and social consequences, and the philosophical assumptions underlying the…

  13. Controversy Over Student "Rights"

    ERIC Educational Resources Information Center

    Fields, Cheryl

    2005-01-01

    This article reports on the controversy over the "academic bill of rights" that is being pushed by conservative activist David Horowitz of the Center for the Study of Popular Culture. A committee in the Pennsylvania House of Representatives passed a resolution in July that reflects the concerns of this "bill," which has been batted around in state…

  14. Contact dermatitis: facts and controversies.

    PubMed

    Wolf, Ronni; Orion, Edith; Ruocco, Eleonora; Baroni, Adone; Ruocco, Vincenzo

    2013-01-01

    The history of contact dermatitis (CD) is inseparable from the history of the patch test, and the patch test is inseparable from the pioneer in the field, Josef Jadassohn (1860-1936). Despite the fact that we have been diagnosing, treating, and investigating the condition for more than 100 years, there are still many unsolved questions and controversies, which show no signs of coming to an end in the foreseeable future. This contribution reviews and highlights some of the disagreements and discrepancies associated with CD. For example: • What is the real sensitizer in balsam of Peru, one of the most common allergens, and what, if any, is the value of a low-balsam diet? • Is benzalkonium chloride, which has well-known and undisputed irritant properties, a contact allergen as well? • Is cocamidopropyl betaine (CABP) a common contact allergen and what is the actual sensitizer in CABP allergy the molecule itself, or impurities, or intermediaries in its synthesis? • How can the significant differences in the prevalence of sensitization of formaldehyde (FA, a common cause of contact allergy) between the United States (8%-9%) and Europe (2%-3%) be explained? • What is the relationship between formaldehyde releasers (FRs) allergy and an FA allergy? Should we recommend that FA-allergic patients also avoid FRs, and, if so, to what extent? • What is the true frequency of lanolin allergy? This issue remains enigmatic despite the expenditure of thousands of dollars and the innumerable hours spent investigating this subject. • What is the basis behind the so-called "lanolin paradox"? This label was coined in 1996 and is still a matter of controversy. • Is there such a thing as systemic CD from nickel, and, if so, to what extent? Is there a cross-reactivity or concomitant sensitization between nickel and cobalt?These are some of the controversial problems discussed. We have selected the ones that we consider to be of special interest and importance to the

  15. Controversies in dengue pathogenesis.

    PubMed

    Halstead, Scott B

    2012-05-01

    Research into the pathogenesis of dengue fever has exploded over the last half-century, with issues that were considered simple becoming more complex as additional data are found. This has led to the development of a number of controversies that are being studied across the globe and debated in the literature. In this paper, the following six controversies are analysed and, where possible, resolved: the 1997 World Health Organization (WHO) case definition of dengue haemorrhagic fever (DHF) is not useful; DHF is not significantly associated with secondary dengue infection; DHF results from infection with a 'virulent' dengue virus; DHF is owing to abnormal T-cell responses; DHF results from auto-immune responses; and DHF results from direct infection of endothelial cells. PMID:22668442

  16. Quasars, Redshifts and Controversies

    NASA Astrophysics Data System (ADS)

    Arp, Halton C.

    1988-09-01

    Introduction; 1. Distance of quasars; 2. The battle over statistics; 3. Galaxies visibly connected to quasars; 4. Certain galaxies with many quasars; 5. Distribution of quasars in space; 6. Galaxies with excess redshift; 7. Small excess redshifts, the local group of galaxies, and quantization of redshifts; 8. Correcting intrinsic redshifts and identifying hydrogen clouds within nearby groups of galaxies; 9. Ejection from galaxies; 10. The sociology of the controversy; 11. Interpretations; Glossary; Index.

  17. Controversies in vaccine mandates.

    PubMed

    Lantos, John D; Jackson, Mary Anne; Opel, Douglas J; Marcuse, Edgar K; Myers, Angela L; Connelly, Beverly L

    2010-03-01

    Policies that mandate immunization have always been controversial. The controversies take different forms in different contexts. For routine childhood immunizations, many parents have fears about both short- and long-term side effects. Parental worries change as the rate of vaccination in the community changes. When most children are vaccinated, parents worry more about side effects than they do about disease. Because of these worries, immunization rates go down. As immunization rates go down, disease rates go up, and parents worry less about side effects of vaccination and more about the complications of the diseases. Immunization rates then go up. For teenagers, controversies arise about the criteria that should guide policies that mandate, rather than merely recommend and encourage, certain immunizations. In particular, policy makers have questioned whether immunizations for human papillomavirus, or other diseases that are not contagious, should be required. For healthcare workers, debates have focused on the strength of institutional mandates. For years, experts have recommended that all healthcare workers be immunized against influenza. Immunizations for other infections including pertussis, measles, mumps, and hepatitis are encouraged but few hospitals have mandated such immunizations-instead, they rely on incentives and education. Pandemics present a different set of problems as people demand vaccines that are in short supply. These issues erupt into controversy on a regular basis. Physicians and policy makers must respond both in their individual practices and as advisory experts to national and state agencies. The articles in this volume will discuss the evolution of national immunization programs in these various settings. We will critically examine the role of vaccine mandates. We will discuss ways that practitioners and public health officials should deal with vaccine refusal. We will contrast responses of the population as a whole, within the

  18. Controversies in Screening Mammography.

    PubMed

    Swain, Monique; Jeudy, Myrlene; Pearlman, Mark D

    2016-06-01

    The utility and effectiveness of screening mammography in diagnosing breast cancer at earlier stages and reducing disease-specific mortality remain controversial especially as to when to start and stop routine mammographic screening, and whether mammograms should be performed annually or biennially in average-risk women. This manuscript will analyze the available moderate and high-quality data to analyze both the benefits (lives saved and life-years saved) and inconveniences/harms (additional views, extra biopsies/overdiagnosis, and overtreatment of ductal carcinoma in situ) of different mammography screening guidelines to assist the practitioner in counseling their patients in clinical practice. PMID:27101240

  19. Controversy at Love Canal.

    PubMed

    Paigen, B

    1982-06-01

    A cancer researcher reviews the events surrounding the toxic waste contamination at Love Canal with emphasis on the political nature of the controversy about its health impact. Antagonism between the community and the New York State Department of Health was fueled by several factors: the state's awareness that it gained from delay in investigation, disagreement on health problems to be studied, control over the information gathering process, silencing of opposition opinion, and the violation of norms of scientific behavior. The author calls for the establishment of standards of ethical behavior for scientists in such situations, standards for conflict resolution, and means of appeal for those injured. PMID:7107238

  20. Electrodynamic force law controversy.

    PubMed

    Graneau, P; Graneau, N

    2001-05-01

    Cavalleri et al. [Phys. Rev. E 52, 2505 (1998); Eur. J. Phys. 17, 205 (1996)] have attempted to resolve the electrodynamic force law controversy. This attempt to prove the validity of either the Ampère or Lorentz force law by theory and experiment has revealed only that the two are equivalent when predicting the force on part of a circuit due to the current in the complete circuit. However, in our analysis of internal stresses, only Ampère's force law agrees with experiment. PMID:11415053

  1. The controversy of Warthin's tumor

    SciTech Connect

    Chapnik, J.S.

    1983-06-01

    Warthin's tumor is controversial. This controversy is multifaceted and relates to all aspects of the tumor from its historical beginnings to its pathogenesis, investigations, and treatments. In this paper, an in depth study of Warthin's tumor has been made to help clarify these controversies.

  2. Exxon Valdez controversy revived

    SciTech Connect

    Not Available

    1993-04-26

    Four years after its occurrence rocked the petroleum industry and revitalized the US environmental movement, the Exxon Valdez tanker oil spill off Alaska continues to stir controversy. Conflicting reports abound over whether there is long term damage to the Prince William Sound ecosystem resulting from the March 24, 1989, spill. Government scientists at recent conferences disclosed studies they contend show long term, significant damage to the sound. Exxon this month launched a counteroffensive, disclosing results of studies it funded that it claims show no credible scientific evidence of long term damage. At the same time, the company blasted as flawed the government's data on assessing environmental damage to the sound and charged that test samples from the sound were mishandled. Meantime, Prince William Sound still shows lingering effects from the Exxon Valdez oil spill. But recovery has been so rapid that there is more controversy over how to use $900 million in natural resource recovery funds that Exxon paid than over how badly species are suffering. The paper describes Exxon's studies; faulty data; lingering damage; and an update on tanker safety.

  3. Sensitivity of frost occurrence to temperature variability in the European Alps

    NASA Astrophysics Data System (ADS)

    Auer, Ingeborg; Matulla, Christoph; Böhm, Reinhard; Ungersböck, Markus; Maugeri, Maurizio; Nanni, Teresa; Pastorelli, Rossella

    2005-11-01

    In this study, we set out to investigate the linkage of frost frequency to monthly mean temperature and its sensitivity to temperature changes. According to other related studies, the linkage between frost frequency and monthly mean temperature is approximated month per month via hyperbolic tangent functions. These models are validated using three validation experiments including split sample tests and temporal cross-validation. As there are quality-checked station data in Austria, whose temporal resolution and length allow for such a validation procedure, the validation experiments are conducted there.After the performance of the empirical models is evaluated and found adequate, the hyperbolic tangent approach is applied to about 500 stations within the so called Greater Alpine region (GAR), which extends from about 4 °E to 18 °E and from 44 °N to 49 °N. Using these models, it is possible to derive the sensitivity of frost frequency for any location for which the annual temperature cycle is known. This strategy is explicitly demonstrated for the Po Plain, where vertical temperature profiles on a monthly base are on hand as well as in Austria, where spatially high resolved maps of monthly mean temperature are available. Moreover, at stations for which long-term homogenised series of monthly mean temperature are available, reconstructions of frost frequency via the empirical models are done, returning to historical periods where no measurements of minimum temperature exist.On the basis of these findings, the impact of a possible future warming can be assessed, which is essential with regard to glaciers, permafrost and avalanches. Reduction in frost might bring positive economic aspects for agriculture, but negative consequences for low level skiing areas. Copyright

  4. Heterogeneity of carbon loss and its temperature sensitivity in East-European subarctic tundra soils.

    PubMed

    Diáková, Kateřina; Čapek, Petr; Kohoutová, Iva; Mpamah, Promise A; Bárta, Jiří; Biasi, Christina; Martikainen, Pertti J; Šantrůčková, Hana

    2016-09-01

    Arctic peatlands store large stocks of organic carbon which are vulnerable to the climate change but their fate is uncertain. There is increasing evidence that a part of it will be lost as a result of faster microbial mineralization. We studied the vulnerability of 3500-5900 years old bare peat uplifted from permafrost layers by cryogenic processes to the surface of an arctic peat plateau. We aimed to find biotic and abiotic drivers of CLOSS from old peat and compare them with those of adjacent, young vegetated soils of the peat plateau and mineral tundra. The soils were incubated in laboratory at three temperatures (4°C, 12°C and 20°C) and two oxygen levels (aerobic, anaerobic). CLOSS was monitored and soil parameters (organic carbon quality, nutrient availability, microbial activity, biomass and stoichiometry, and extracellular oxidative and hydrolytic enzyme pools) were determined. We found that CLOSS from the old peat was constrained by low microbial biomass representing only 0.22% of organic carbon. CLOSS was only slightly reduced by the absence of oxygen and exponentially increased with temperature, showing the same temperature sensitivity under both aerobic and anaerobic conditions. We conclude that carbon in the old bare peat is stabilized by a combination of physical, chemical and biological controls including soil compaction, organic carbon quality, low microbial biomass and the absence of plants. PMID:27316560

  5. Sensitivity of Earth Wheat Markets to Space Weather: Comparative Analysis based on data from Medieval European Markets

    NASA Astrophysics Data System (ADS)

    Pustil'Nik, Lev

    We consider a problem of the possible influence of unfavorable states of the space weather on agriculture markets through the chain of connections: "space weather"-"earth weather"- "agriculture crops"-"price reaction". We show that new manifestations of "space weather"- "earth weather" relations discovered in the recent time allow revising a wide range of the expected solar-terrestrial connections. In the previous works we proposed possible mechanisms of wheat market reaction on the specific unfavorable states of space weather in the form of price bursts and price asymmetry. We point out that implementation of considered "price reaction scenarios" is possible only for the case of simultaneous realization of several necessary conditions: high sensitivity of local earth weather in the selected region to space weather; the state of "high risk agriculture" in the selected agriculture zone; high sensitivity of agricultural market to a possible deficit of yield. Results of our previous works (I, II), including application of this approach to the Medieval England wheat market (1250-1700) and to the modern USA durum market (1910-1992), showed that connection between wheat price bursts and space weather state in these cases was absolutely real. The aim of the present work is to answer the question why wheat markets in one selected region may be sensitive to a space weather factor, while in other regions wheat markets demonstrate absolutely indifferent reaction on the space weather. For this aim, we consider dependence of sensitivity of wheat markets to space weather as a function of their location in different climatic zones of Europe. We analyze a database of 95 European wheat markets from 14 countries for the 600-year period (1260-1912). We show that the observed sensitivity of wheat markets to space weather effects is controlled, first of all, by a type of predominant climate in different zones of agricultural production. Wheat markets in the Northern and, partly, in

  6. The controversy over change.

    PubMed

    Brandon, A N

    1978-01-01

    The full impact of twentieth century technology upon medical libraries was first felt in the late 1950s and early 1960s with the introduction of electronic automation into library methodology. During those years, often the aura of technology for the sake of technology prevailed, and medical librarians did little to inform themselves of capabilities, potentialities, and limitations in relation to cost-effective library usage of automation. Likewise, currently microforms and audiovisuals are frequently acquired for their own sake instead of for their capacity to transmit messages in the most effective and comprehensive way possible. Controversy has raged and still rages over the pros and cons of applying modern technology to library procedures and over the coexistence of the printed page with electronic media. New systems and methodologies, machine or manual, must realistically be evaluated in terms of increased service output by the library to its clientele. Regardless of technological sophistication, any machine that does not significantly contribute to that specific aim has no place in a library. The tradition of the medical librarian has always been to collect, organize, store, and disseminate information in the most efficient manner that the media of the times have had to offer. PMID:75031

  7. Radon Treatment Controversy

    PubMed Central

    Zdrojewicz, Zygmunt; Strzelczyk, Jadwiga (Jodi)

    2006-01-01

    In spite of long traditions, treatments utilizing radon-rich air or water have not been unequivocally embraced by modern medicine. The objective of this work is to examine factors that contribute to this continuing controversy. While the exact mechanism of radon's effect on human body is not completely understood, recent advances in radiobiology offer new insights into biochemical processes occurring at low-level exposures to ionizing radiation. Medical evidence and patients' testimonials regarding effectiveness of radon spa treatments of various ailments, most notably rheumatoid arthritis are accumulating worldwide. They challenge the premise of the Linear-No-Threshold (LNT) theory that the dose-effect response is the same per unit dose regardless of the total dose. Historically, such inference overshadowed scientific inquiries into the low-dose region and lead to a popular belief that no amount of radiation can be good. Fortunately, the LNT theory, which lacks any scientific basis, did not remain unchallenged. As the reviewed literature suggests, a paradigm shift, reflected in the consideration of hormetic effects at low-doses, is gaining momentum in the scientific community worldwide. The impetus comes from significant evidence of adaptive and stimulatory effects of low-levels of radiation on human immune system. PMID:18648641

  8. Photoprotection: facts and controversies.

    PubMed

    Skotarczak, K; Osmola-Mańkowska, A; Lodyga, M; Polańska, A; Mazur, M; Adamski, Z

    2015-01-01

    Excessive exposure of the skin to sunlight can lead to many negative effects, such as sunburn, photoaging and skin cancer development. Pollution and stratospheric ozone layer depletion are factors that increase exposure to ultraviolet radiation. This work is an accurate summary of the current state of knowledge on broad-spectrum photoprotection. Avoiding the sun, skin protection through the use of protective clothing and protective filters are currently the most effective methods of sunscreen provided that they are suitably used. In addition, discussed are controversial issues such as the toxicity of zinc used in sunscreen preparations and the potential for deficiency of vitamin D3 in relation with the application of strict photoprotection. The study has also addressed issues concerning the most recent lines of research in the exploration of modern methods of photoprotection both local and systemic, such as with the use of photolyase or examination of various enzymes repairing damage after sun exposure, as well as the promising future in photoprotection technology. PMID:25635982

  9. Sensitivity of the regional European boreal climate to changes in surface properties resulting from structural vegetation perturbations

    NASA Astrophysics Data System (ADS)

    Rydsaa, J. H.; Stordal, F.; Tallaksen, L. M.

    2015-05-01

    Amplified warming at high latitudes over the past few decades has led to changes in the boreal and Arctic climate system such as structural changes in high-latitude ecosystems and soil moisture properties. These changes trigger land-atmosphere feedbacks through altered energy partitioning in response to changes in albedo and surface water fluxes. Local-scale changes in the Arctic and boreal zones may propagate to affect large-scale climatic features. In this study, MODIS land surface data are used with the Weather Research and Forecasting model (WRF V3.5.1) and Noah land surface model (LSM), in a series of experiments to investigate the sensitivity of the overlying atmosphere to perturbations in the structural vegetation in the northern European boreal ecosystem. Emphasis is placed on surface energy partitioning and near-surface atmospheric variables, and their response to observed and anticipated land cover changes. We find that perturbations simulating northward migration of evergreen needleleaf forest into tundra regions cause an increase in latent rather than sensible heat fluxes during the summer season. Shrub expansion in tundra areas has only small effects on surface fluxes. Perturbations simulating the northward migration of mixed forest across the present southern border of the boreal forest, have largely opposite effects on the summer latent heat flux, i.e., they lead to a decrease and act to moderate the overall mean regional effects of structural vegetation changes on the near-surface atmosphere.

  10. Teen Addiction. Current Controversies Series.

    ERIC Educational Resources Information Center

    Winters, Paul A., Ed.

    The Current Controversies series explores social, political, and economic controversies that dominate the national and international scenes today from a variety of perspectives. Recent surveys have shown that, after years of decline, drug use among teenagers has increased during the 1990s, and that alcohol and tobacco use have remained…

  11. Examining Controversies in Adult Education.

    ERIC Educational Resources Information Center

    Kreitlow, Burton W.; And Others

    Controversies over adult education purposes, methods, audiences, and procedures are examined. After outlining a procedure for reviewing competing positions on controversial topics, the book pairs the contrasting views of two authors on each of 10 key issues facing adult education. Chapters cover: philosophies at issue (David L. Boggs); identifying…

  12. The Continuing Valencian Language Controversy.

    ERIC Educational Resources Information Center

    Neugaard, Edward J.

    1995-01-01

    Controversy lingers regarding the name of the language spoken in the Spanish autonomous province of Valencia. Although the variety of Catalan spoken there has long been called both "Catalan" and "Valencian," recent controversy has become bitter and often surrounded by violence. Despite the debate, the language is in danger of dying out. (nine…

  13. The Great School Bus Controversy.

    ERIC Educational Resources Information Center

    Mills, Nicolaus, Ed.

    This anthology attempts to put the great school bus controversy of the 1970's in perspective by providing a forum in which a series of widely differing views, backed by hard data, can be compared. The first section, "Background and Legal History," places the controversy in a perspective that predates the 1970's. One article focuses on the history…

  14. The Science-Textbook Controversies

    ERIC Educational Resources Information Center

    Nelkin, Dorothy

    1976-01-01

    The discrepancies between science and creationism are reflected in curriculum controversies. Students should be free to choose which theory they like, according to the creationists who view Darwinian science as incompatible with absolute moral values. (DS)

  15. Controversies in Parotid Defect Reconstruction.

    PubMed

    Tamplen, Matthew; Knott, P Daniel; Fritz, Michael A; Seth, Rahul

    2016-08-01

    Reconstruction of the parotid defect is a complex topic that encompasses restoration of both facial form and function. The reconstructive surgeon must consider facial contour, avoidance of Frey syndrome, skin coverage, tumor surveillance, potential adjuvant therapy, and facial reanimation when addressing parotid defects. With each defect there are several options within the reconstructive ladder, creating controversies regarding optimal management. This article describes surgical approaches to reconstruction of parotid defects, highlighting areas of controversy. PMID:27400838

  16. Necrotizing enterocolitis: controversies and challenges

    PubMed Central

    Zani, Augusto; Pierro, Agostino

    2015-01-01

    Necrotizing enterocolitis is a devastating intestinal disease that affects ~5% of preterm neonates. Despite advancements in neonatal care, mortality remains high (30–50%) and controversy still persists with regards to the most appropriate management of neonates with necrotizing enterocolitis. Herein, we review some controversial aspects regarding the epidemiology, imaging, medical and surgical management of necrotizing enterocolitis and we describe new emerging strategies for prevention and treatment. PMID:26918125

  17. Sexual Orientation, Controversy, and Science.

    PubMed

    Bailey, J Michael; Vasey, Paul L; Diamond, Lisa M; Breedlove, S Marc; Vilain, Eric; Epprecht, Marc

    2016-09-01

    SummaryOngoing political controversies around the world exemplify a long-standing and widespread preoccupation with the acceptability of homosexuality. Nonheterosexual people have seen dramatic surges both in their rights and in positive public opinion in many Western countries. In contrast, in much of Africa, the Middle East, the Caribbean, Oceania, and parts of Asia, homosexual behavior remains illegal and severely punishable, with some countries retaining the death penalty for it. Political controversies about sexual orientation have often overlapped with scientific controversies. That is, participants on both sides of the sociopolitical debates have tended to believe that scientific findings-and scientific truths-about sexual orientation matter a great deal in making political decisions. The most contentious scientific issues have concerned the causes of sexual orientation-that is, why are some people heterosexual, others bisexual, and others homosexual? The actual relevance of these issues to social, political, and ethical decisions is often poorly justified, however. PMID:27113562

  18. Amino acid sequence of the AhR1 ligand-binding domain predicts avian sensitivity to dioxin like compounds: in vivo verification in European starlings.

    PubMed

    Eng, Margaret L; Elliott, John E; Jones, Stephanie P; Williams, Tony D; Drouillard, Ken G; Kennedy, Sean W

    2014-12-01

    Research has demonstrated that the sensitivity of avian species to the embyrotoxic effects of dioxin-like compounds can be predicted by the amino acid identities at two key sites within the ligand-binding domain of the aryl hydrocarbon receptor 1 (AhR1). The domestic chicken (Gallus gallus domesticus) has been established as a highly sensitive species to the toxic effects of dioxin-like compounds. Results from genotyping and in vitro assays predict that the European starling (Sturnus vulgaris) is also highly sensitive to dioxin-like compound toxicity. The objective of the present study was to test that prediction in vivo. To do this, we used egg injections in field nesting starlings with 3,3',4,4',5-pentachlorobiphenyl (PCB-126), a dioxin-like polychlorinated biphenyl. Eggs were dosed with either the vehicle control or 1 of 5 doses (1.4, 7.1, 15.9, 32.1, and 52.9 ng PCB-126/g egg). A dose-dependent increase in embryo mortality occurred, and the median lethal dose (LD50; 95% confidence interval [CI]) was 5.61 (2.33-9.08) ng/g. Hepatic CYP1A4/5 messenger RNA (mRNA) expression in hatchlings also increased in a dose-dependent manner, with CYP1A4 being more induced than CYP1A5. No effect of dose on morphological measures was seen, and we did not observe any overt malformations. These results indicate that, other than the chicken, the European starling is the most sensitive species to the effects of PCB-126 on avian embryo mortality reported to date, which supports the prediction of relative sensitivity to dioxin-like compounds based on amino acid sequence of the AhR1. PMID:25209921

  19. The Academic Controversy Technique: Towards Cooperative Debates

    ERIC Educational Resources Information Center

    Jacobs, George M.

    2010-01-01

    The purpose of this paper is to introduce and explain a cooperative learning technique, Academic Controversy (Johnson, Johnson, & Smith, 1996), also known as Cooperative Controversy, Structured Controversy and Structured Academic Controversy, that has potential for use in education and other areas, and has support in both research and theory.…

  20. Surveying Students about Controversial Subjects

    ERIC Educational Resources Information Center

    Soronen, Lisa E.

    2007-01-01

    Background: Because of school districts' interest in best serving the health needs of students, many choose to administer surveys addressing controversial topics. Administering such surveys in a voluntary and anonymous manner may help reduce conflict. Methods: This is a review of 2 recent federal court of appeals decisions regarding surveying…

  1. Darwinian Controversies: An Historiographical Recounting

    ERIC Educational Resources Information Center

    Depew, David J.

    2010-01-01

    This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race,…

  2. The Controversy around Black History.

    ERIC Educational Resources Information Center

    Pitre, Abul; Ray, Ruth

    2002-01-01

    Controversy over black history began in 1926, when Carter G. Woodson introduced Negro history week, and has continued into the 21st century. Proponents of black history believe it promotes diversity, develops self-esteem, and corrects myths and stereotypes. Opponents argue it is dishonest, divisive, and lacks academic credibility and rigor.…

  3. Teacher Quality, Controversy, and NCLB

    ERIC Educational Resources Information Center

    Porter-Magee, Kathleen

    2004-01-01

    No Child Left Behind (NCLB)--the sweeping federal law that requires all schools that receive federal Title I dollars to be held strictly accountable for student outcomes--is the most discussed education reform effort in the past half century. One of the many controversial and vexing elements of the law, especially among teachers, teacher unions,…

  4. Women's Athletics: Coping with Controversy.

    ERIC Educational Resources Information Center

    Hoepner, Barbara J., Ed.

    This book is a collection of papers discussing controversial topics in women's athletics. Section one, "Overview--Women's Rights," includes articles on women's rights and equal opportunities in sports, the emergence of women in sports, and significant events in a century of American women's sports. Section two, "Women's Intercollegiate…

  5. Elementary 72 - The Great Controversy

    ERIC Educational Resources Information Center

    Allsop, R. T.

    1973-01-01

    Discusses the controversy about the discovery of element 72, involving Urbain's isolation of celtium, Dauvillier's reexamination of celtium samples, and Coster and Hevesy's announcement of the existence of hafnium. Indicates that the Copenhagen workers are finally accredited for the element discovery in their x-ray spectral studies. (CC)

  6. Embracing Controversy in the Classroom

    ERIC Educational Resources Information Center

    Cannard, Kelly

    2005-01-01

    Discussing controversial topics such as stem cell research is a great way for students to build scientific understanding, enhance communication skills, and develop an appreciation for civic decision making. Tackling a topic such as stem cells at the middle level, however, can be a challenge because most young adolescents see the world in black and…

  7. Engaging Students in Controversial Issues

    ERIC Educational Resources Information Center

    Malikow, Max

    2006-01-01

    A year ago, an upstate New York college withdrew a speaking invitation to Wade Churchill, a University of Colorado professor who had characterized 9/11 victims as "little Eichmanns." Churchill's portrayal of 9/11 victims as a mixture of conscious and unwitting participants in a systemic evil of Holocaust proportions indeed was controversial. The…

  8. Teaching Controversial Issues of Bioethics.

    ERIC Educational Resources Information Center

    Stronck, David R.

    Many teachers avoid controversial topics because they do not want to upset students or parents, do not know appropriate instructional strategies, and fail to recognize the importance of motivating students through placing science in its relevant context. An example is provided for use in a methods course for helping future high school teachers to…

  9. Eliminating Racism: Profiles in Controversy.

    ERIC Educational Resources Information Center

    Katz, Phyllis A., Ed.; Taylor, Dalmas A., Ed.

    Dialogue and research on racism since the mid-1970s have yielded increased controversy over the theories, foundation, and continued existence of racism. The chapters presented in this book provide various divergent views of what constitutes racism and frameworks for reducing it. The following chapters (and their authors) are included: (1)…

  10. Controversial Curriculum? Ask the Community!

    ERIC Educational Resources Information Center

    Davis, William Jeffrey

    2009-01-01

    Involving communities in the process of curriculum development may not be novel, but it seems lacking with regard to controversial issues such as lessons on diverse family structures, homosexuality, and other special situations. Disparity in values and convictions can lead one person to support a decision, while another person might hold an…

  11. The Satanic Ritual Abuse Controversy.

    ERIC Educational Resources Information Center

    Putnam, Frank W.

    1991-01-01

    The issues raised by Jonker and Jonker-Bakker and Young et al (EC 601 187-188) illustrate a major controversy dividing the child abuse community, the alleged existence of a conspiracy of satanic, ritual, sexual abuse of children. No evidence is found to support claims that large numbers of babies and children are being sacrificed or abused in…

  12. What can we learn from European continuous atmospheric CO2 measurements to quantify regional fluxes Part 2: Sensitivity of flux accuracy to inverse setup

    NASA Astrophysics Data System (ADS)

    Carouge, C.; Peylin, P.; Rayner, P. J.; Bousquet, P.; Chevallier, F.; Ciais, P.

    2008-10-01

    An inverse model using atmospheric CO2 observations from a European network of stations to reconstruct daily CO2 fluxes and their uncertainties over Europe at 50 km resolution has been developed within a Bayesian framework. We use the pseudo-data or identical twin approach in which we try to recover known fluxes using a range of perturbations to the input. In this second part, the focus is put on the sensitivity of flux accuracy to the inverse setup, varying the prior flux errors, the pseudo-data errors and the network of stations. We show that, under a range of assumptions about prior error and data error we can recover fluxes reliably at the scale of 1000 km and 10 days. At smaller scales the performance is highly sensitive to details of the inverse set-up. The use of temporal correlations in the flux domain appears to be of the same importance as the spatial correlations. We also note that the use of simple, isotropic correlations on the prior flux errors is more reliable than the use of apparently physically-based errors. Finally, increasing the European atmospheric network density improves the area with significant error reduction in the flux retrieval.

  13. Controversies in Pediatric Perioperative Airways

    PubMed Central

    Klučka, Jozef; Štourač, Petr; Štoudek, Roman; Ťoukálková, Michaela; Harazim, Hana; Kosinová, Martina

    2015-01-01

    Pediatric airway management is a challenge in routine anesthesia practice. Any airway-related complication due to improper procedure can have catastrophic consequences in pediatric patients. The authors reviewed the current relevant literature using the following data bases: Google Scholar, PubMed, Medline (OVID SP), and Dynamed, and the following keywords: Airway/s, Children, Pediatric, Difficult Airways, and Controversies. From a summary of the data, we identified several controversies: difficult airway prediction, difficult airway management, cuffed versus uncuffed endotracheal tubes for securing pediatric airways, rapid sequence induction (RSI), laryngeal mask versus endotracheal tube, and extubation timing. The data show that pediatric anesthesia practice in perioperative airway management is currently lacking the strong evidence-based medicine (EBM) data that is available for adult subpopulations. A number of procedural steps in airway management are derived only from adult populations. However, the objective is the same irrespective of patient age: proper securing of the airway and oxygenation of the patient. PMID:26759809

  14. Controversial Science and the Media

    NASA Astrophysics Data System (ADS)

    Riordon, James

    2012-03-01

    The possibility that the OPERA collaboration has detected superluminal neutrinos was among the most controversial topics in physics news in decades, and one of the most widely covered stories in all of science in 2011. Word of the research initially reached journalists and the public prior to publication in peer-reviewed journals. Understandably, many physicists are concerned that the significance of controversial science may be exaggerated or distorted when news organizations report on science at such an early stage. I will offer an overview of the ways the story was promoted by the media relations personnel, and outline the rationales that motivate media relations efforts along with the associated benefits and drawbacks that can result. Finally, I will examine the accuracy and completeness of the superluminal neutrino news stories that ultimately were made available to the general public.

  15. Controversial Science and the Media

    NASA Astrophysics Data System (ADS)

    Riordon, James

    2012-02-01

    The possibility that the OPERA collaboration has detected superluminal neutrinos was among the most controversial topics in physics news in decades, and one of the most widely covered stories in all of science in 2011. Word of the research initially reached journalists and the public prior to publication in peer-reviewed journals. Understandably, many physicists are concerned that the significance of controversial science may be exaggerated or distorted when news organizations report on science at such an early stage. I will offer an overview of the ways the story was promoted by the media relations personnel, and outline the rationales that motivate media relations efforts along with the associated benefits and drawbacks that can result. Finally, I will examine the accuracy and completeness of the superluminal neutrino news stories that ultimately were made available to the general public.

  16. "Smoky Night" and "Crack": Controversial Subjects in Current Children's Stories.

    ERIC Educational Resources Information Center

    Koehnecke, Dianne

    2001-01-01

    Discusses two children's picture books: "Smoky Night" and "The House that Crack Built." Notes that the books deal with the Los Angeles riots and the use and distribution of crack cocaine. Concludes that each book treats important issues with sensitivity and honesty and is engaging, even when dealing with controversial topics in a didactic…

  17. Is Race Really Controversial in the University Classroom?

    ERIC Educational Resources Information Center

    Philion, Stephen

    2009-01-01

    Today, even though "social justice" programs exist as a virtual growth industry on US campuses and many universities have incorporated classes on race and racism into their curricula, everyone continues to be faced with the perception that race is a "controversial" topic that has to be broached with care due to its "sensitive nature". This is even…

  18. EFFECT OF PARTICULATE MATTER (PM) COLLECTED IN TWO EUROPEAN CITIES ON ALLERGIC SENSITIZATION AND ALLERGIC RESPONSES IN MICE

    EPA Science Inventory

    Children (5-14 years old) living in the industrial city of Hettstedt (H) in eastern Germany were reported to have a higher incidence of sensitization to common aeroallergens compared to another cohort living in the nearby city of Zerbst (Z) which has less industrial pollution (He...

  19. Structured Controversy: A Case Study Strategy.

    ERIC Educational Resources Information Center

    Herreid, Clyde Freeman

    1996-01-01

    Introduces a dynamic form of the case instruction method that involves debate and compromise. Discusses two versions of structured controversy and presents an example of structured controversy that involves the use of DNA fingerprinting in forensic medicine. (JRH)

  20. Main controversies in breast cancer

    PubMed Central

    Zervoudis, Stephane; Iatrakis, George; Tomara, Eirini; Bothou, Anastasia; Papadopoulos, George; Tsakiris, George

    2014-01-01

    In this article, we have reviewed available evidence for diagnosis, treatment, and follow-up in female breast cancer (BC). Into daily clinical practice some controversies are occurred. Especially, in the diagnosis field, despite the fact that the optimal age in which screening mammography should start is a subject of intense controversy, there is a shift toward the beginning at the age of 40 although it is suggested that the net benefit is small for women aged 40 to 49 years. In addition, a promising tool in BC screening seems to be breast tomosynthesis. Other tools such as 3D ultrasound and shear wave elastography (SWE) are full of optimism in BC screening although ultrasonography is not yet a first-line screening method and there is insufficient evidence to recommend the systemic use of the SWE for BC screening. As for breast magnetic resonance imaging (MRI), even if it is useful in BC detection in women who have a strong family history of BC, it is not generally recommended as a screening tool. Moreover, based on the lack of randomized clinical trials showing a benefit of presurgical breast MRI in overall survival, it’s integration into breast surgical operations remains debatable. Interestingly, in contrast to fine needle aspiration, core biopsy has gained popularity in presurgical diagnosis. Furthermore, after conservative surgery in patients with positive sentinel lymph nodes, the recent tendency is the shift from axillary dissection to axillary conserving strategies. While the accuracy of sentinel lymph node after neoadjuvant chemotherapy and second BC surgery remains controversial, more time is needed for evaluation and for determining the optimal interval between the two surgeries. Additionally, in the decision between immediate or delayed breast reconstruction, there is a tendency in the immediate use. In the prevention of BC, the controversial issue between tamoxifen and raloxifene becomes clear with raloxifene be more profitable through the toxicities

  1. Current controversies in infective endocarditis

    PubMed Central

    Cahill, Thomas J.; Prendergast, Bernard D.

    2015-01-01

    Infective endocarditis is a life-threatening disease caused by a focus of infection within the heart. For clinicians and scientists, it has been a moving target that has an evolving microbiology and a changing patient demographic. In the absence of an extensive evidence base to guide clinical practice, controversies abound. Here, we review three main areas of uncertainty: first, in prevention of infective endocarditis, including the role of antibiotic prophylaxis and strategies to reduce health care-associated bacteraemia; second, in diagnosis, specifically the use of multimodality imaging; third, we discuss the optimal timing of surgical intervention and the challenges posed by increasing rates of cardiac device infection. PMID:26918142

  2. Controversies in Contemporary Facial Reanimation.

    PubMed

    Kim, Leslie; Byrne, Patrick J

    2016-08-01

    Facial palsy is a devastating condition with profound functional, aesthetic, and psychosocial implications. Although the complexity of facial expression and intricate synergy of facial mimetic muscles are difficult to restore, the goal of management is to reestablish facial symmetry and movement. Facial reanimation surgery requires an individualized treatment approach based on the cause, pattern, and duration of facial palsy while considering patient age, comorbidities, motivation, and goals. Contemporary reconstructive options include a spectrum of static and dynamic procedures. Controversies in the evaluation of patients with facial palsy, timing of intervention, and management decisions for dynamic smile reanimation are discussed. PMID:27400842

  3. Risky, early, controversial. Puberty in medical discourses.

    PubMed

    Cozzi, Donatella; Vinel, Virginie

    2015-10-01

    This article comes within the compass of a research program (entitled CorAge. Bodily Experiences and AgePassages among 9-13 year-olds (ANR-09-ENFT-017) conducted between 2009 and 2013 about the emergence of a "new" age in life--"preadolescence"--as instanced in France (Alsace, Lorraine) and Italy (Venetia). The impressive amount of references to "early puberty" and "precocious puberty", in a context of feeling of a premature end of childhood, led us to make an in-depth study of this issue: first, through an analysis of international and French and Italian medical journals; second, through interviews with health professionals. Following the thesis of Foucault, we assume that the discourses on puberty timing participate of classifications of the child body drenched with moral representations of childhood, especially on gender and age issue. Our results: the question of whether a secular trend in puberty timing even exists continues to be debated between American and European scientists. Second, the terms "puberty", "precocious puberty", "early puberty" have been used to indicate a variety of puberty markers, increasing confusion. A controversy has focused on early breast development in girls, because this attribute is questioning the order of ages and gender. Moreover, psychosocial factors presented as accelerating early puberty, do not demonstrate the relation between earliness and risk behavior. The literature, as it is moved by the female precocity, creates a medical category to objectify the complex and flexible process of puberty and invent female child precocity. These differences between American and European scholars and the interviews with French and Italian health professional show a gap between the international literature and practitioners, clinicians and nurses who regularly work with children: they neither find pubertal advancement, nor increase of "true precocious puberty", although they share concerns about premature feminization of girls (France) or

  4. Current controversies in childhood vaccination.

    PubMed

    Carrillo-Marquez, Maria; White, Lisa

    2013-01-01

    As pediatric practitioners, one of the contemporary challenges in providing medical care for children is the increasing proportion of vaccination refusal. This occurs in spite of the demonstrated individual and collective benefit and cost effectiveness of vaccination. Controversies regarding vaccine components and side effects have misled parents to believe that vaccines might be harmful based on inaccurate data from the Internet, celebrities, as well as misinterpreted and frankly bad science. This belief of vaccines being harmful has led to fear and decreased immunization rates in spite of sound scientific evidence supporting the safety of vaccines and their lack of association with autism, developmental disabilities or other medical disorders. Some parents also believe in alternative ways to avoid disease, often adhering to practices that have little foundation in the best of empiric science. It is not a coincidence that recent outbreaks of vaccine-preventable diseases, including measles and pertussis (whooping cough), have occurred in areas where vaccination has declined largely due to exemptors. This article intends to review some of the common vaccine myths and controversies and to serve as a resource to provide accurate information and references for busy practitioners and the families that we serve. PMID:23444591

  5. Teaching controversial issues in the secondary school science classroom

    NASA Astrophysics Data System (ADS)

    van Rooy, Wilhelmina

    1993-12-01

    A sample of fourteen secondary school biology teachers chosen from twelve schools were interviewed. The purpose was to determine their views on how controversial issues in science might be handled in the secondary school science classroom and whether the issues of surrogacy and human embryo experimentation were suitable controversial issues for discussion in schools. In general, teachers indicated that controversial issues deserve a more prominent place in the science curriculum because they have the potential to foster thinking, learning, and interest in science. The issues of surrogacy and human embryo experimentation were seen as appropriate contexts for learning, provided that teachers were well informed and sensitive to both the students and to the school environment.

  6. South Africa's AIDS play provokes controversy.

    PubMed

    Lee, N

    1996-03-01

    The European Union (EU) has earmarked a total of 40 million rand (US$12 million) to foster AIDS awareness in South Africa. 14.27 million rand, approximately US$3.45 million, has been allocated by the Department of Health to fund "Sarafina 2," a controversial musical show about AIDS awareness written by Mbongeni Ngema. The allocation of such a large portion of EU funding to this one play has been strongly criticized. The funds could have instead been used to provide essential services. In response, the Department of Health claims that the money had not been subjected to the usual checking processes because the amount had been specifically dedicated to the production of the play. The EU ambassador, however, has reportedly stated that the play was never discussed and was not part of their program. The director of the AIDS directorate was out of the country when Ngema's tender for the play was accepted last August, and it was not until November that she learned about her department's sponsoring of the play. The health department has now forbade its employees from discussing the matter with the media. Minister of Health Nkosazana Zuma should expect a tough time when she goes before Manto Tshabalala's parliamentary portfolio committee on health which has been charged with investigating the matter. The committee will also review some of the accounting related to this issue. PMID:8596329

  7. Impacts of pesticide mixtures in European rivers as predicted by the Species Sensitivity Distribution (SSD) models and SPEAR bioindication

    NASA Astrophysics Data System (ADS)

    Jesenska, Sona; Liess, Mathias; Schäfer, Ralf; Beketov, Mikhail; Blaha, Ludek

    2013-04-01

    Species sensitivity distribution (SSD) is statistical method broadly used in the ecotoxicological risk assessment of chemicals. Originally it has been used for prospective risk assessment of single substances but nowadays it is becoming more important also in the retrospective risk assessment of mixtures, including the catchment scale. In the present work, SSD predictions (impacts of mixtures consisting of 25 pesticides; data from several catchments in Germany, France and Finland) were compared with SPEAR-pesticides, which a bioindicator index based on biological traits responsive to the effects of pesticides and post-contamination recovery. The results showed statistically significant correlations (Pearson's R, p<0.01) between SSD (predicted msPAF values) and values of SPEAR-pesticides (based on field biomonitoring observations). Comparisons of the thresholds established for the SSD and SPEAR approaches (SPEAR-pesticides=45%, i.e. LOEC level, and msPAF = 0.05 for SSD, i.e. HC5) showed that use of chronic toxicity data significantly improved the agreement between the two methods but the SPEAR-pesticides index was still more sensitive. Taken together, the validation study shows good potential of SSD models in predicting the real impacts of micropollutant mixtures on natural communities of aquatic biota.

  8. Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature.

    PubMed

    Schnuch, Axel; Uter, Wolfgang; Geier, Johannes; Lessmann, Holger; Frosch, Peter J

    2007-07-01

    To study the frequency of sensitization to 26 fragrances to be labelled according to current European regulation. During 4 periods of 6 months, from 1 January 2003 to 31 December 2004, 26 fragrances were patch tested additionally to the standard series in a total of 21 325 patients; the number of patients tested with each of the fragrances ranged from 1658 to 4238. Hydroxymethylpentylcyclohexene carboxaldehyde (HMPCC) was tested throughout all periods. The following frequencies of sensitization (rates in %, standardized for sex and age) were observed: tree moss (2.4%), HMPCC (2.3), oak moss (2.0), hydroxycitronellal (1.3), isoeugenol (1.1), cinnamic aldehyde (1.0), farnesol (0.9), cinnamic alcohol (0.6), citral (0.6), citronellol (0.5), geraniol (0.4), eugenol (0.4), coumarin (0.4), lilial (0.3), amyl-cinnamic alcohol (0.3), benzyl cinnamate (0.3), benzyl alcohol (0.3), linalool (0.2), methylheptin carbonate (0.2), amyl-cinnamic aldehyde (0.1), hexyl-cinnamic aldehyde (0.1), limonene (0.1), benzyl salicylate (0.1), gamma-methylionon (0.1), benzyl benzoate (0.0), anisyl alcohol (0.0). 1) Substances with higher sensitization frequencies were characterized by a considerable number of '++/+++' reactions. 2) Substances with low sensitization frequencies were characterized by a high number of doubtful/irritant and a low number of stronger (++/+++) reactions. 3) There are obviously fragrances among the 26 which are, with regard to contact allergy, of great, others of minor, and some of no importance at all. PMID:17577350

  9. Subclinical hypothyroidism: Controversies to consensus

    PubMed Central

    Raza, Syed Abbas; Mahmood, Nasir

    2013-01-01

    Diagnoses of subclinicaal hypothyroidism (SCH) is biochemically made, when serum thyroid stimulating hormone (TSH) levels is elevated while free thyroid hormone levels are within normal reference range. SCH is diagnosed after excluding all other causes of elevated TSH levels. Symptoms of SCH may vary from being asymptomatic to having mild nonspecific symptoms. The risk of progression to overt hypothyroidism is related to number of factors including initial serum TSH concentration, presence of auto antibodies, family history and presence goiter. Various screening recommendations for thyroid function assessment are in practice. There are still controversies surrounding SCH and associated risk of various cardiovascular diseases (CVDs), pregnancy outcomes, neuropsychiatric issues, metabolic syndrome, and dyslipidemia. Consensus will require more large randomized clinical studies involving various age groups and medical condition, especially in developing countries. All these efforts will definitely improve our understanding of disease and ultimately patient outcomes. PMID:24910826

  10. Cholesterol confusion and statin controversy.

    PubMed

    DuBroff, Robert; de Lorgeril, Michel

    2015-07-26

    The role of blood cholesterol levels in coronary heart disease (CHD) and the true effect of cholesterol-lowering statin drugs are debatable. In particular, whether statins actually decrease cardiac mortality and increase life expectancy is controversial. Concurrently, the Mediterranean diet model has been shown to prolong life and reduce the risk of diabetes, cancer, and CHD. We herein review current data related to both statins and the Mediterranean diet. We conclude that the expectation that CHD could be prevented or eliminated by simply reducing cholesterol appears unfounded. On the contrary, we should acknowledge the inconsistencies of the cholesterol theory and recognize the proven benefits of a healthy lifestyle incorporating a Mediterranean diet to prevent CHD. PMID:26225201

  11. Cholesterol confusion and statin controversy

    PubMed Central

    DuBroff, Robert; de Lorgeril, Michel

    2015-01-01

    The role of blood cholesterol levels in coronary heart disease (CHD) and the true effect of cholesterol-lowering statin drugs are debatable. In particular, whether statins actually decrease cardiac mortality and increase life expectancy is controversial. Concurrently, the Mediterranean diet model has been shown to prolong life and reduce the risk of diabetes, cancer, and CHD. We herein review current data related to both statins and the Mediterranean diet. We conclude that the expectation that CHD could be prevented or eliminated by simply reducing cholesterol appears unfounded. On the contrary, we should acknowledge the inconsistencies of the cholesterol theory and recognize the proven benefits of a healthy lifestyle incorporating a Mediterranean diet to prevent CHD. PMID:26225201

  12. Controversies Among the Hypertension Guidelines.

    PubMed

    Ripley, Toni L; Baumert, Mary

    2016-02-01

    Hypertension affects 80 million people in the United States. It remains poorly controlled, with only 54% of diagnosed patients treated to blood pressure targets. Hypertension management is complex in part due to the volume of antihypertensive agents, variable patient needs and responses, and inconsistent design and outcomes from clinical trials. Therefore, trustworthy clinical practice guidelines have a key role in hypertension management. The United States experienced a 10-year gap in publication of hypertension guidelines, followed by multiple guideline publications in 2013. These guidelines led to more controversy than clarity, as there was discordance among them. This review summarizes the guidelines and clinical statements influencing the current debate in order to facilitate appropriate application. PMID:26668216

  13. Thermoluminescence survey of 12 meteorites collected by the European 1988 Antarctic meteorite expedition to Allan Hills and the importance of acid washing for thermoluminescence sensitivity measurements

    SciTech Connect

    Benoit, P.H.; Sears, H.; Sears, D.W.G. )

    1991-06-01

    Natural and induced thermoluminescence (TL) data are reported for 12 meteorites recovered from the Allan Hills region of Antarctica by the European field party during the 1988/1989 field season. The samples include one with extremely high natural TL, ALH88035, suggestive of exposure to unusually high radiation doses (i.e., low degrees of shielding), and one, ALH88034, whose low natural TL suggests reheating within the last 100,000 years. The remainder have natural TL values suggestive of terrestrial ages similar to those of other meteorites from Allan Hills. ALH88015 (L6) has induced TL data suggestive of intense shock. TL sensitivities of these meteorites are generally lower than observed falls of their petrologic types, as is also observed for Antarctic meteorites in general. Acid-washing experiments indicate that this is solely the result of terrestrial weathering rather than a nonterrestrial Antarctic-non-Antarctic difference. However, other TL parameters, such as natural TL and induced peak temperature-width, are unchanged by acid washing and are sensitive indicators of a meteorite's metamorphic and recent radiation history. 16 refs.

  14. Thermoluminescence survey of 12 meteorites collected by the European 1988 Antarctic meteorite expedition to Allan Hills and the importance of acid washing for thermoluminescence sensitivity measurements

    NASA Technical Reports Server (NTRS)

    Benoit, P. H.; Sears, H.; Sears, D. W. G.

    1991-01-01

    Natural and induced thermoluminescence (TL) data are reported for 12 meteorites recovered from the Allan Hills region of Antarctica by the European field party during the 1988/1989 field season. The samples include one with extremely high natural TL, ALH88035, suggestive of exposure to unusually high radiation doses (i.e., low degrees of shielding), and one, ALH88034, whose low natural TL suggests reheating within the last 100,000 years. The remainder have natural TL values suggestive of terrestrial ages similar to those of other meteorites from Allan Hills. ALH88015 (L6) has induced TL data suggestive of intense shock. TL sensitivities of these meteorites are generally lower than observed falls of their petrologic types, as is also observed for Antarctic meteorites in general. Acid-washing experiments indicate that this is solely the result of terrestrial weathering rather than a nonterrestrial Antarctic-non-Antarctic difference. However, other TL parameters, such as natural TL and induced peak temperature-width, are unchanged by acid washing and are sensitive indicators of a meteorite's metamorphic and recent radiation history.

  15. Thermoluminescence survey of 12 meteorites collected by the European 1988 Antarctic meteorite expedition to Allan Hills and the importance of acid washing for thermoluminescence sensitivity measurements

    NASA Astrophysics Data System (ADS)

    Benoit, P. H.; Sears, H.; Sears, D. W. G.

    1991-06-01

    Natural and induced thermoluminescence (TL) data are reported for 12 meteorites recovered from the Allan Hills region of Antarctica by the European field party during the 1988/1989 field season. The samples include one with extremely high natural TL, ALH88035, suggestive of exposure to unusually high radiation doses (i.e., low degrees of shielding), and one, ALH88034, whose low natural TL suggests reheating within the last 100,000 years. The remainder have natural TL values suggestive of terrestrial ages similar to those of other meteorites from Allan Hills. ALH88015 (L6) has induced TL data suggestive of intense shock. TL sensitivities of these meteorites are generally lower than observed falls of their petrologic types, as is also observed for Antarctic meteorites in general. Acid-washing experiments indicate that this is solely the result of terrestrial weathering rather than a nonterrestrial Antarctic-non-Antarctic difference. However, other TL parameters, such as natural TL and induced peak temperature-width, are unchanged by acid washing and are sensitive indicators of a meteorite's metamorphic and recent radiation history.

  16. Darwinian Controversies: An Historiographical Recounting

    NASA Astrophysics Data System (ADS)

    Depew, David J.

    2010-05-01

    This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race, culture, and eugenics at the 1959 centenary celebration Darwin’s Origin of Species; adaptationism and its critics in the Sociobiology debate of 1970s and, more recently, Evolutionary Psychology; and current disputes about Intelligent Design. These controversies, I argue, are etched into public memory because they occur at the emotionally charged boundaries between public-political, technical-scientific, and personal-religious spheres of discourse. Over most of them falls the shadow of eugenics. The main lesson is that the history of Darwinism cannot be told except by showing the mutual influence of the different norms of discourse that obtain in the personal, technical, and public spheres. Nor can evolutionary biology successfully be taught to citizens and citizens-to-be until the fractious intersections between spheres of discourse have been made explicit. In the course of showing why, I take rival evolutionary approaches to be dynamical historical research traditions rather than static theories. Accordingly, I distinguish Darwin’s version of Darwinism from its later transformations. I pay special attention to the role Darwin assigned to development in evolution, which was marginalized by twentieth-century population genetical Darwinism, but has recently resurfaced in new forms. I also show how the disputed phrases “survival of the fittest” and “social Darwinism” have shaped personal anxieties about “Darwinism,” have provoked public opposition to teaching evolution in public schools, and have cast a shadow over efforts to effectively communicate to the public largely successful technical efforts to make

  17. Estimates of European uptake of CO2 inferred from GOSAT XCO2 retrievals: sensitivity to measurement bias inside and outside Europe

    NASA Astrophysics Data System (ADS)

    Feng, L.; Palmer, P. I.; Parker, R. J.; Deutscher, N. M.; Feist, D. G.; Kivi, R.; Morino, I.; Sussmann, R.

    2016-02-01

    GOSAT data in 2010 is due to retrievals outside the immediate European region, while the remainder can largely be explained by a sub-ppm retrieval bias over Europe. We use a data assimilation approach to estimate monthly GOSAT XCO2 biases from the joint assimilation of in situ observations and GOSAT XCO2 retrievals. The inferred biases represent an estimate of systematic differences between GOSAT XCO2 retrievals and the inversion system at regional or sub-regional scales. We find that a monthly varying bias of up to 0.5 ppm can explain an overestimate of the annual sink of up to 0.20 GtC a-1. Our results highlight the sensitivity of CO2 flux estimates to regional observation biases, which have not been fully characterized by the current observation network. Without further dedicated measurements we cannot prove or disprove that European ecosystems are taking up a larger-than-expected amount of CO2. More robust inversion systems are also needed to infer consistent fluxes from multiple observation types.

  18. [Sex "addiction": compulsion and controversy].

    PubMed

    Souza y Machorro, Mario

    2002-10-01

    Modern occidental society often distorts and, in some cases, ignores healthy concepts regarding sexuality. Besides, It not always considers this, to be mental health or to represent an expression of whole health. Such ambivalence towards sex and the sexual is located between the limits of the sacred and erotic, both associated to taboos and their transgression. Since the last century, the current "neosexual" revolution intents to dismantle old patterns in favor of the dissociation of human sexual sphere, the dispersion of sexual fragments towards individualism and intimate relationships diversification. Within such context, "addiction" to sex and the sexual, as a compulsive conduct, represents on one side a clinical reality each time better observed and diagnosed, where the importance of family history is recognized, as well as individual psychopathology, and marital life, in its etiology and also for its treatment and prevention. On the other hand, it has not been classified in the mental health catalogues as it is not considered, meanwhile, as the problem is been maintained, the co-morbidity and its consequences multiply, and the controversy continues. PMID:12557802

  19. Controversies in kidney paired donation.

    PubMed

    Gentry, Sommer E; Montgomery, Robert A; Segev, Dorry L

    2012-07-01

    Kidney paired donation represented 10% of living kidney donation in the United States in 2011. National registries around the world and several separate registries in the United States arrange paired donations, although with significant variations in their practices. Concerns about ethical considerations, clinical advisability, and the quantitative effectiveness of these approaches in paired donation result in these variations. For instance, although donor travel can be burdensome and might discourage paired donation, it was nearly universal until convincing analysis showed that living donor kidneys can sustain many hours of cold ischemia time without adverse consequences. Opinions also differ about whether the last donor in a chain of paired donation transplants initiated by a nondirected donor should donate immediately to someone on the deceased donor wait-list (a domino or closed chain) or should be asked to wait some length of time and donate to start another sequence of paired donations later (an open chain); some argue that asking the donor to donate later may be coercive, and others focus on balancing the probability that the waiting donor withdraws versus the number of additional transplants if the chain can be continued. Other controversies in paired donation include simultaneous versus nonsimultaneous donor operations, whether to enroll compatible pairs, and interactions with desensitization protocols. Efforts to expand public awareness of and participation in paired donation are needed to generate more transplant opportunities. PMID:22732046

  20. Bisphenol A: Understanding the Controversy.

    PubMed

    Metz, Cynthia Marie

    2016-01-01

    Healthy People 2020 lists Bisphenol A (BPA) as a potential endocrine disruptor for which exposure should be reduced. The Healthy People 2020 Environmental Health Objectives focus on addressing environmental factors that negatively affect individuals' health even though the health effects of some toxic substances are not yet fully understood. An American Association of Occupational Health Nurses (AAOHN) position statement outlined the role occupational health nurses play in creating healthy and productive workplaces by promoting worker health. BPA is implicated in a variety of health outcomes such as breast and prostate cancer, menstrual irregularities, genital abnormalities in male babies, infertility in men and women, early puberty in girls, and metabolic disorders such as diabetes and obesity. The overall health issues attributed to BPA exposure are complex and controversial. Concerns regarding environmental health are growing as individuals become more dependent on plastics. Numerous health concerns have been directly connected to daily exposures to products manufactured with BPA. Government agencies support the use of BPA as a safe consumer product with the exception of BPA use in baby bottles and sippy cups, which has been banned in the United States and several other countries. Many agencies (e.g., Federal Drug Administration [FDA], World Health Organization [WHO], U.S. Department of Health & Human Services [U.S. DHHS], and the Centers for Disease Control and Prevention [CDC]) have expressed "some concern" about BPA based on research, and stated further research is warranted. PMID:26800896

  1. HPV vaccines: a controversial issue?

    PubMed Central

    Nicol, A.F.; Andrade, C.V.; Russomano, F.B.; Rodrigues, L.L.S.; Oliveira, N.S.; Provance, D.W.

    2016-01-01

    Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects. We found that the majority of studies continue to suggest a positive risk-benefit from vaccination against HPV, with minimal documented adverse effects, which is consistent with other vaccines. However, much of the published scientific data regarding the safety of HPV vaccines appears to originate from within the financially competitive HPV vaccine market. We advocate a more independent monitoring system for vaccine immunogenicity and adverse effects to address potential conflicts of interest with regular systematic literature reviews by qualified individuals to vigilantly assess and communicate adverse effects associated with HPV vaccination. Finally, our evaluation suggests that an expanded use of HPV vaccine into more diverse populations, particularly those living in low-resource settings, would provide numerous health and social benefits. PMID:27074168

  2. Advances and controversies in yellow fever vaccination.

    PubMed

    Jonker, Emile F F; Visser, Leonardus G; Roukens, Anna H

    2013-11-01

    Ever since its development in 1937, the live-attenuated 17D yellow fever (YF) vaccine has been one of the most effective vaccines available to man. In this review we highlight the major steps in the development of 17D YF vaccine. We discuss the use of neutralizing antibodies as a surrogate marker for protection, and explore the strengths and weaknesses of the current plaque reduction neutralization test (PRNT), a technique developed in the 1960s that continues to be superior to every modern test in both sensitivity and specificity. The neutralizing antibodies demonstrated by the PRNT can be detected for several decades after vaccination, possibly even for the remainder of the recipient's natural life. We review the available evidence on the duration of protection after primary vaccination, a topic that has been the subject of controversy over the last few months. For persons who are immunocompromised due to disease, medication or advancing age, the duration of protection may be shorter: they should always have their vaccine response checked by PRNT. Due to the higher risk of severe adverse events after vaccination with 17D YF in this group, the development of a new, inactivated vaccine will have substantial benefits in this population. PMID:24757521

  3. Environmental Sensitive Areas (ESAs) changes in the Canyoles river watershed in Eastern Spain since the European Common Agriculture Policies (CAP) implementation

    NASA Astrophysics Data System (ADS)

    Ángel González Peñaloza, Félix; Cerdà, Artemi

    2014-05-01

    The Enviromental Sensitive Areas (ESAs) approach to study the Land Degradation is a methodology developed by professor Costas Kosmas et al., (1999) to map environmental sensitive areas and then the impact of Land Degradation and desertification on Mediterranean Type Ecosystems (Salvati et al., 2013). This methodology has been applied mainly to the Mediterranean Belt (Lavado Contador et al., 2009), but other authors adapted the methodology to other climatic regions (Izzo et al., 2013). The ESAs methodology allows mapping changes in the distribution of the sensitive areas to Desertification as a consequence of biophysical or human chances. In the Mediterranean countries of Europe, especially Spain, suffered a dramatic change due to the application of the European Common Agricultural Policies (CAP) after 1992. The objective of the CAP was to implemented policies to improve the environmental conditions of agricultural land. This target is especially relevant in Mediterranean areas of Spain, mainly the South and the East of the country. An Environmental Sensitive Area (ESAs) model (Kosmas et al., 2009) was implemented using Geographical Information System (GIS) tools, to identify, assess, monitor and map the levels of sensitivity to land degradation in the Canyoles river watershed, which is a representative landscape of the Mediterranean belt in Eastern Spain The results show that it was found that after the implementation of CAP, the most sensitive areas have expanded. This increase in degraded areas is driven by the expansion of commercial and chemically managed crops that increased the soil erosion (Cerdà et al., 2009) and that few soil conservation strategies were applied (Giménez Morera et al., 2010). Another factor that triggered Desertification processes is the increase in the recurrencesof forest fires as a consequence of land abandonment (Cerdà and Lasanta, 2005; Cerdà and Doerr, 2007). This contributed to an increase of scrubland. Our research show an

  4. Get Controversial! Edgy Novels for Older Teens

    ERIC Educational Resources Information Center

    Cox Clark, Ruth

    2007-01-01

    This article is a discussion of authors and controversial novels that should be on the top of library media specialists' reading list if they work with high-school-age teens. "Controversial" is not a dirty word, it is an enticement! The goal of library media specialists is to get teens who may be burned out with reading due to incentive programs…

  5. Teachers, Classroom Controversy, and the Media

    ERIC Educational Resources Information Center

    Faulconer, Tracy; Freeman, Ayesha Coning

    2005-01-01

    This article discusses the relationship between teachers, classroom controversy and the media. It also features the story of Ayesha, who coincidentally is one of the authors of this article. Ayesha's story is a social studies teacher's bad dream featuring one of her worst fears: (1) public criticism; and (2) controversy over something that has…

  6. History Forum Addresses Creation/Evolution Controversy.

    ERIC Educational Resources Information Center

    Schweinsberg, John

    1997-01-01

    A series of programs entitled Creationism and Evolution: The History of a Controversy was presented at the University of Alabama in Huntsville. The controversy was addressed from an historical and sociological, rather than a scientific perspective. Speakers addressed the evolution of scientific creationism, ancient texts versus sedimentary rocks…

  7. Teaching about NAFTA Using Academic Controversy.

    ERIC Educational Resources Information Center

    Starr, Eileen M.

    1997-01-01

    Examines a teaching strategy called "constructive controversy" where students are required to argue both the pro and con positions concerning a controversial current topic. Describes students' response to a class using this method to examine the North American Free Trade Agreement (NAFTA). Student response was generally favorable. (MJP)

  8. Nuclear Weapons: Concepts, Issues, and Controversies.

    ERIC Educational Resources Information Center

    Reardon, Betty; And Others

    1983-01-01

    The schools must confront and deal with the issues of the nuclear weapons controversy on pain of ceasing to be relevant to the critical needs of the rising generation. Every aspect of the nuclear arms controversy needs to be discussed in secondary and university classrooms. (RM)

  9. Evolutionary Psychology: Controversies, Questions, Prospects, and Limitations

    ERIC Educational Resources Information Center

    Confer, Jaime C.; Easton, Judith A.; Fleischman, Diana S.; Goetz, Cari D.; Lewis, David M. G.; Perilloux, Carin; Buss, David M.

    2010-01-01

    Evolutionary psychology has emerged over the past 15 years as a major theoretical perspective, generating an increasing volume of empirical studies and assuming a larger presence within psychological science. At the same time, it has generated critiques and remains controversial among some psychologists. Some of the controversy stems from…

  10. Bureaucratic Constructions of Sexual Diversity: "Sensitive", "Controversial" and Silencing

    ERIC Educational Resources Information Center

    Ullman, Jacqueline; Ferfolja, Tania

    2015-01-01

    National research illustrates the high degree of discrimination that prevails against lesbian, gay, bisexual, transgender and queer (LGBTQ) students resulting in diminished educational outcomes, both academic and social. This phenomenon is influenced by the prevalence of whole-school silences around LGBTQ topics in many Australian schools. This…

  11. Global controversies and advances in skin cancer.

    PubMed

    Baldwin, Louise; Dunn, Jeff

    2013-01-01

    Advances and controversies of skin cancer prevention in the Asian-Pacific region are to be examined the world's first Global Controversies and Advances in Skin Cancer Conference to be held in Brisbane, Australia this November. APOCP Members are cordially invited to register early for the opportunity to contribute to the debate on a cancer which continues to be a prominent issue in the Asia Pacific and indeed worldwide. We need answers to the questions of why a cancer that is so preventable and easily detectable is still shrouded in controversy. Primary focuses will be on issues like viral involvement, vaccines and novel clinical approaches. PMID:23725105

  12. Qualitative research: comments and controversies.

    PubMed

    Schutz, R W

    1989-03-01

    Larry Locke's timely and well-written introduction to qualitative research procedures will undoubtedly serve its purpose. It makes us reassess our traditional beliefs and practices, educates us on the rudiments of qualitative methodology, and, hopefully, makes us more tolerant and appreciative of alternate ways of conducting research. Although Locke focuses his paper on pedagogical research issues, it is important to realize that many other sub-disciplines within the general field of physical education also utilize qualitative procedures. For example, 10 years ago Martens (1979) called for a paradigm shift in sport psychology by appealing to researchers to abandon their labs and to embark on naturalistic field studies. While North American sport psychologists, and psychologists in general, have been slow to formalize qualitative techniques, the European psychology community has been much more active (e.g., Ashworth, Giorgi, & de Koning, 1986). Perhaps Locke's article will encourage researchers in all our sub-disciplines to consider the utility of qualitative research. Hopefully, readers will treat Locke's article as an introduction to the broad area of qualitative research and not as a rigorous set of procedures for conducting participant observation research in school physical education studies. Additionally, it must be recognized that there are other approaches and other applications, that the area has its critics and its unresolved methodological problems, and that qualitative research does not necessarily exclude the application of formalized data analyses. Keeping these issues in mind, the addition of qualitative approaches to our repetoire of research methodologies can only enhance the quality of research in physical education and exercise and sport science. PMID:2489822

  13. Environmental Sensitive Areas (ESAs) changes in the Canyoles river watershed in Eastern Spain since the European Common Agriculture Policies (CAP) implementation

    NASA Astrophysics Data System (ADS)

    Ángel González Peñaloza, Félix; Cerdà, Artemi

    2014-05-01

    The Enviromental Sensitive Areas (ESAs) approach to study the Land Degradation is a methodology developed by professor Costas Kosmas et al., (1999) to map environmental sensitive areas and then the impact of Land Degradation and desertification on Mediterranean Type Ecosystems (Salvati et al., 2013). This methodology has been applied mainly to the Mediterranean Belt (Lavado Contador et al., 2009), but other authors adapted the methodology to other climatic regions (Izzo et al., 2013). The ESAs methodology allows mapping changes in the distribution of the sensitive areas to Desertification as a consequence of biophysical or human chances. In the Mediterranean countries of Europe, especially Spain, suffered a dramatic change due to the application of the European Common Agricultural Policies (CAP) after 1992. The objective of the CAP was to implemented policies to improve the environmental conditions of agricultural land. This target is especially relevant in Mediterranean areas of Spain, mainly the South and the East of the country. An Environmental Sensitive Area (ESAs) model (Kosmas et al., 2009) was implemented using Geographical Information System (GIS) tools, to identify, assess, monitor and map the levels of sensitivity to land degradation in the Canyoles river watershed, which is a representative landscape of the Mediterranean belt in Eastern Spain The results show that it was found that after the implementation of CAP, the most sensitive areas have expanded. This increase in degraded areas is driven by the expansion of commercial and chemically managed crops that increased the soil erosion (Cerdà et al., 2009) and that few soil conservation strategies were applied (Giménez Morera et al., 2010). Another factor that triggered Desertification processes is the increase in the recurrencesof forest fires as a consequence of land abandonment (Cerdà and Lasanta, 2005; Cerdà and Doerr, 2007). This contributed to an increase of scrubland. Our research show an

  14. Controversial Issues within Biology: Enriching Biology Teaching.

    ERIC Educational Resources Information Center

    Van Rooy, Wilhelmina

    2000-01-01

    Describes the development and implementation of a senior high school biology lesson concerned with organ transplantation. Discusses the teacher's rationale and techniques for using controversial issues in science teaching. (Contains 18 references.) (Author/WRM)

  15. Sorting Out the Video Game Controversy.

    ERIC Educational Resources Information Center

    Crespi, Pam

    1983-01-01

    This article looks at the controversy over video games; arguments for and against them are offered, along with a list of regulations in force around the country and nine important factors agencies should consider before leasing the machines. (JM)

  16. Another Look at Controversial Issues and the Curriculum.

    ERIC Educational Resources Information Center

    Gardner, Peter

    1984-01-01

    Controversial issues should be taught in school. Charles Bailey's and R.F. Dearden's opinions of what makes an issue controversial are critiqued. Bailey accounts for controversial issues in behavioral terms; Dearden advances an epistemic account. (RM)

  17. Early Controversies over Athetosis: I. Clinical Features, Differentiation from other Movement Disorders, Associated Conditions, and Pathology

    PubMed Central

    Lanska, Douglas J.

    2013-01-01

    Background Since the description of athetosis in 1871 by American neurologist William Alexander Hammond (1828–1900) the disorder has been a source of controversy, as were many aspects of Hammond’s career. Methods Primary sources have been used to review controversies in the 50-year period since the initial description of athetosis, in particular those concerning clinical features, differentiation from other movement disorders, associated conditions, and pathology. Controversies concerning treatment will be addressed in a subsequent article. Results Hammond struggled to establish athetosis as a distinct clinical–pathological entity, and had successfully predicted the striatal pathology in his initial case (albeit somewhat serendipitously). Athetosis was, nevertheless, considered by many neurologists to be a form of post-hemiplegic chorea or part of a continuum between chorea and dystonia. European neurologists, and particularly the French, initially ignored or discounted the concept. Additional controversies arose over whether the movements persisted during sleep, whether athetosis was, or could be, associated with imbecility or insanity, and how it should be treated. Discussion Some controversies concerning athetosis served to identify areas where knowledge was insufficient to make accurate statements, despite prior self-assured or even dogmatic statements to the contrary. Other controversies illustrated established prejudices, even if these biases were often only apparent with the greater detachment of hindsight. PMID:23450262

  18. Contrasting Controversies: Fracking and Climate Change

    NASA Astrophysics Data System (ADS)

    Duggan-Haas, D.; Zabel, I. H. H.; Ross, R. M.

    2014-12-01

    Slickwater high-volume hydraulic fracturing (commonly known as "fracking") is highly controversial. So is global warming, and the two issues are closely related, but the natures of these two controversies have substantial and important differences. Building upon years of experience in teaching and developing resources and strategies for teaching about evolution and climate change, staff at the Paleontological Research Institution have engaged in public outreach and educator professional development to help nurture understanding of fracking and the broader energy system. How are these controversies similar to and different from one another, and how should understanding these similarities and differences inform educational programming (and about how you talk about these issues with your Uncle Fred at the family holiday dinner?). It is nearly universally agreed amongst scientists who study climate that changes now underway are real and human caused, and are posing or likely to pose very serious problems for humanity. Scientists who study slickwater high-volume hydraulic fracturing agree that it causes environmental damage, but there is no consensus as to whether fracking causes more or less harm (e.g., among different kinds of environment harm, across different temporal and spatial scales, and among different social contexts) than other ways of producing energy on a large scale. In other words, the basic tenets of climate change are not a matter of scientific controversy, though the implications for policy making obviously remain politically controversial, while fracking is an issue of both scientific and political controversy. Without advocating for or against fracking, we help audiences disentangle scientific and political issues, better understand the energy resources used in their own communities, and consider issues of scale, systems, and complexity. We will compare and contrast the overlapping controversies surrounding climate change and fracking and highlight

  19. Polycystic ovary syndrome: the controversy of diagnosis by ultrasound.

    PubMed

    Porter, Misty Blanchette

    2008-05-01

    Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder. The criteria used to establish the diagnosis remain controversial. The 1990 National Institutes of Health conference guidelines required a combination of both chronic anovulation and clinical/or biochemical signs of hyperandrogenism. These criteria were revised in 2003 at the Rotterdam European Society of Human Reproduction and Embryology/American Society of Reproductive Medicine consensus workshop to include ultrasound polycystic ovarian morphology (PCOM) as one of the two of three criteria necessary for establishing the diagnosis of PCOS. The inclusion of PCOM sparked a controversy as it broadens the population of women who meet the criteria for PCOS and allows for the creation of two phenotypically different patient populations who previously would have been excluded. The ultrasound findings, which are consistent with PCOM, include an assessment of follicle number and/or ovarian volume. As technology advances with two-dimensional and three-dimensional ultrasound, our ability to discretely evaluate independent portions of the ovary may help to redefine the criteria of PCOM and thus standardize for clinical and research interests a more specific descriptor for PCOM. PMID:18504699

  20. European Academies Advise on Gain-of-Function Studies in Influenza Virus Research

    PubMed Central

    Fears, Robin

    2015-01-01

    Gain-of-function (GoF) studies to understand factors affecting transmissibility of potentially pandemic pathogens are controversial. The European Academies Science Advisory Council (EASAC) recently published consensus recommendations relating to GoF research review and management on self-regulation and harmonization; bioethical considerations; benefit-risk assessment; biosafety, and biosecurity advisory options; and publication of sensitive information. A layered approach to integration of responsibilities must include conforming to the stringent rules and guidance already existing. Further commitment is essential to extend the debate on issues worldwide. PMID:26699646

  1. The Relationship of Metabolic Syndrome Traits with Beta-Cell Function and Insulin Sensitivity by Oral Minimal Model Assessment in South Asian and European Families Residing in the Netherlands

    PubMed Central

    Jainandunsing, Sjaam; de Rooij, Felix W. M.

    2016-01-01

    Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity index (ISI), static, dynamic, and total beta-cell responsivity indices (Φ), and disposition indices (DIs) were calculated with the use of oral minimal model (OMM). Results. In both ethnicities, ISI was lower in the subgroup with MetS and T2D as compared to the subgroup without MetS nor T2D (P < 0.004). South Asians without MetS were more insulin resistant than Europeans without MetS (P = 0.033). In the South Asians, ISI, dynamic DI, and static DI were associated significantly (P < 0.006) with high-density lipoprotein cholesterol and triglycerides. In the Europeans, ISI was associated with waist-to-hip ratio (P = 0.005) and systolic and diastolic blood pressure (P < 0.005), while static DI was related to the systolic blood pressure (P = 0.005). Conclusions. MetS was linked with insulin resistance and reduced capacity to handle glucose regardless of ethnicity. ISI and DIs were associated with lipid traits in South Asians and with blood pressure in Europeans suggesting that insulin resistance enhances different metabolic syndrome traits among different ethnicities. PMID:27597980

  2. The Relationship of Metabolic Syndrome Traits with Beta-Cell Function and Insulin Sensitivity by Oral Minimal Model Assessment in South Asian and European Families Residing in the Netherlands.

    PubMed

    Geragotou, Thekla; Jainandunsing, Sjaam; Özcan, Behiye; de Rooij, Felix W M; Kokkinos, Alexander; Tentolouris, Nicholas; Sijbrands, Eric J G

    2016-01-01

    Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity index (ISI), static, dynamic, and total beta-cell responsivity indices (Φ), and disposition indices (DIs) were calculated with the use of oral minimal model (OMM). Results. In both ethnicities, ISI was lower in the subgroup with MetS and T2D as compared to the subgroup without MetS nor T2D (P < 0.004). South Asians without MetS were more insulin resistant than Europeans without MetS (P = 0.033). In the South Asians, ISI, dynamic DI, and static DI were associated significantly (P < 0.006) with high-density lipoprotein cholesterol and triglycerides. In the Europeans, ISI was associated with waist-to-hip ratio (P = 0.005) and systolic and diastolic blood pressure (P < 0.005), while static DI was related to the systolic blood pressure (P = 0.005). Conclusions. MetS was linked with insulin resistance and reduced capacity to handle glucose regardless of ethnicity. ISI and DIs were associated with lipid traits in South Asians and with blood pressure in Europeans suggesting that insulin resistance enhances different metabolic syndrome traits among different ethnicities. PMID:27597980

  3. The controversy of cranial bone motion.

    PubMed

    Rogers, J S; Witt, P L

    1997-08-01

    Cranial bone motion continues to stimulate controversy. This controversy affects the general acceptance of some intervention methods used by physical therapists, namely, cranial osteopathic and craniosacral therapy techniques. Core to these intervention techniques is the belief that cranial bone mobility provides a compliant system where somatic dysfunction can occur and therapeutic techniques can be applied. Diversity of opinion over the truth of this concept characterizes differing viewpoints on the anatomy and physiology of the cranial complex. Literature on cranial bone motion was reviewed for the purpose of better understanding this topic. Published research overall was scant and inconclusive. Animal and human studies demonstrate a potential for small magnitude motion. Physical therapists should carefully scrutinize the literature presented as evidence for cranial bone motion. Further research is needed to resolve this controversy. Outcomes research, however, is needed to validate cranial bone mobilization as an effective treatment. PMID:9243408

  4. Endoscope Reprocessing: Update on Controversial Issues

    PubMed Central

    Choi, Hyun Ho

    2015-01-01

    Several issues concerning endoscope reprocessing remain unresolved based on currently available data. Thus, further studies are required to confirm standard practices including safe endoscope shelf life, proper frequency of replacement of some accessories including water bottles and connecting tubes, and microbiological surveillance testing of endoscopes after reprocessing. The efficacy and cost-effectiveness of newer technology that allows automated cleaning and disinfection is one such controversial issue. In addition, there are no guidelines on whether delayed reprocessing and extended soaking may harm endoscope integrity or increase the bioburden on the external or internal device surfaces. In this review, we discuss the unresolved and controversial issues regarding endoscope reprocessing. PMID:26473115

  5. Evolution as a Controversial Issue: A Review of Instructional Approaches

    ERIC Educational Resources Information Center

    Hermann, Ronald S.

    2008-01-01

    Although evolution has long been considered a controversial issue, little effort has been made to ensure that instructional approaches address the controversial nature of the issue. A framework for understanding the nature of controversy and some defining characteristics of controversial issues are provided. In light of this framework evolution is…

  6. Courting Controversy: How to Build Interdisciplinary Units.

    ERIC Educational Resources Information Center

    Williams, Jackie; Reynolds, Terry Deal

    1993-01-01

    By focusing on a polluted river and a visit to a rural Tennessee town, sixth-grade students from suburban Asheville, North Carolina, learned more about this controversy than many of their well-informed parents and teachers. Steps for creating similar interdisciplinary thematic units are described, along with the benefits of team teaching and…

  7. Federal Judge Orders Showing of Controversial Film.

    ERIC Educational Resources Information Center

    Flygare, Thomas J.

    1987-01-01

    Reviews a recent court decision in Nebraska regarding the cancellation of a controversial film on the University of Nebraska campus. The film was cancelled after a state senator threatened to close the theater if the movie was shown. The lawsuit alleged the university violated the First Amendment in cancelling the film; the judge ruled for the…

  8. Controversial Novels and Censorship in the Schools.

    ERIC Educational Resources Information Center

    Katz, John Stuart

    The legal history of censorship in general in the United States as well as the legal context in particular of the censorship of novels from schools is discussed. This thesis deals with four novels which have aroused substantial controversy when taught in the schools. The novels are: "The Catcher in the Rye," by J. D. Salinger, "The Adventures of…

  9. Science, Politics, and the IQ Controversy.

    ERIC Educational Resources Information Center

    Snyderman, Mark; Rothman, Stanley

    1986-01-01

    The controversy over intelligence testing is more often influenced by political considerations than empirical research. A survey of 1,020 experts found that a majority agree that (1) intelligence can be defined; (2) heredity plays a role in individual and group IQ differences; and (3) intelligence testing in schools should continue at its present…

  10. Apraxia of Speech: Concepts and Controversies

    ERIC Educational Resources Information Center

    Ziegler, Wolfram; Aichert, Ingrid; Staiger, Anja

    2012-01-01

    Purpose: This article was written as an editorial to a collection of original articles on apraxia of speech (AOS) in which some of the more recent advancements in the understanding of this syndrome are discussed. It covers controversial issues concerning the theoretical foundations of AOS. Our approach was motivated by a change of perspective on…

  11. LCA – Unique and Controversial Case Studies

    EPA Science Inventory

    This session will focus on case studies and applications that have a unique or controversial aspect. Some of the most recent topics that seem to have significant interest include: LCA-based product declarations, LCA-based standards, LCA-based labels, alternative energy, agricul...

  12. Controversial Issues in Our Schools. Fastback 146.

    ERIC Educational Resources Information Center

    Goldstein, William

    There is virtually nothing taught in the American public school that is not potentially explosive at some time or place. America's cultural makeup provides for the development of controversy whenever such issues as sex, religion, politics, and economics are raised, and particularly when they are raised in the school environment. School…

  13. Anticipation and Controversy Surround "Superman" Release

    ERIC Educational Resources Information Center

    Aarons, Dakarai I.

    2010-01-01

    Well in advance of its official release, the education film "Waiting For Superman" has attracted a level of attention that could make it one of the year's most-watched documentaries--and one of the most controversial among educators, some of whom question its depictions of the American school system and how to improve it. Made by director Davis…

  14. Parental Voices and Controversies in Autism

    ERIC Educational Resources Information Center

    Langan, Mary

    2011-01-01

    Parents of children with autism have played a prominent role in controversies surrounding this condition. Parental voices were critical in challenging the "refrigerator mother" theory and more recently have attracted public attention for claims that autism may be caused by childhood vaccinations and that "unorthodox biomedical" treatments may…

  15. Controversial Issues: A Case for Neutrality?

    ERIC Educational Resources Information Center

    Cain, Paul

    1999-01-01

    Arguments against teachers asserting their own views about controversial issues say that neutrality enables students to develop autonomous reflection. Others claim that a nonneutral stance is morally preferable. There are some teaching situations in which a neutral stance may not be an option. (SK)

  16. Controversies in Pediatric Sports Medicine (Commentary).

    ERIC Educational Resources Information Center

    Dyment, Paul G.

    1989-01-01

    Discusses controversial issues that have arisen in children's sports, including infant exercise programs, trampolines, amenorrhea in the adolescent athlete, coed contact sports, and sport participation by children with Down Syndrome. Policy statements are included from the American Academy of Pediatrics. (JD)

  17. Teaching Controversial Issues in Social Studies.

    ERIC Educational Resources Information Center

    Guyton, Edith M.; Hoffman, Alan J.

    The design of a methods course offered at Georgia State University to prepare social studies teachers for dealing with controversial issues in the middle school or secondary social studies classroom is presented. The course focuses on identification, selection, an analysis of an issue as well as the requirement that the student develop some method…

  18. Debating Diversity: Ethics and Controversial Public Issues

    ERIC Educational Resources Information Center

    Darr, Christopher R.

    2016-01-01

    Courses: Ethics, Organizational Communication, Political Communication. Objectives: After completing this unit activity, students should be able to (1) apply multiple ethical perspectives to real-world diversity issues in a debate format, and (2) explain the role of informational and social category diversity in current controversies.

  19. A Constructive Controversy Approach to "Case Studies"

    ERIC Educational Resources Information Center

    Bird, Sharon R.; Erickson, Karla A.

    2010-01-01

    On the basis of analysis of student responses to a case study titled "Drinks and Dinner," the authors evaluate the pedagogical potential of using constructive controversy case studies to teach about inequality. "Drinks and Dinner" is designed to capture the complexity of social interactions that defy simple solutions to engage students in…

  20. Controversy, Trials, and Crime--Oh My!

    ERIC Educational Resources Information Center

    Rott, Kim

    2006-01-01

    Teenagers' innate interest with the justice system is one of the reasons that so many high school literary classics teem with criminals, controversial issues, and trials. Novels such as "To Kill a Mockingbird," "A Separate Peace," "The Crucible," and "Twelve Angry Men" feature high-impact trials. In the author's desire to tap into this interest,…

  1. Controversial Therapies: A Review and Critique.

    ERIC Educational Resources Information Center

    Rooney, Karen J.

    1991-01-01

    The article offers guidelines to educators evaluating controversial therapies and applies them to four such therapies: tinted lenses as a cure for dyslexia; orthomolecular treatments for learning disabilities; pharmaceutical intervention for dyslexia; and visual training for children with learning disabilities. (DB)

  2. 30 CFR 281.9 - Jurisdictional controversies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Jurisdictional controversies. 281.9 Section 281.9 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF General § 281.9...

  3. 30 CFR 282.7 - Jurisdictional controversies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Jurisdictional controversies. 282.7 Section 282.7 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OPERATIONS IN THE OUTER CONTINENTAL SHELF FOR MINERALS OTHER THAN OIL, GAS, AND SULPHUR General §...

  4. Evolution versus Creationism: The Public Education Controversy.

    ERIC Educational Resources Information Center

    Zetterberg, J. Peter, Ed.

    The University of Minnesota organized a conference ("Evolution and Public Education," December 5, 1981) to help clarify issues in the creation/evolution controversy and to examine arguments of the proponents of scientific creationism. This six-part book, a revised version of a resource manual compiled for the conference: (1) discusses the theory…

  5. Behind the Evolution/Creation Controversy.

    ERIC Educational Resources Information Center

    Parker, Franklin

    This paper discusses the historical background of the creationist movement, presents Federal Judge Overton's analysis of why and how the Creationists got the equal time evolution/creation teaching law passed in Arkansas, and examines how scientists and educators are reacting to the controversy. Creationists were set back when Overton declared…

  6. Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions-key messages.

    PubMed

    Gottrup, Finn; Apelqvist, Jan; Bjarnsholt, Thomas; Cooper, Rose; Moore, Zena; Peters, Edgar J G; Probst, Sebastian

    2014-10-01

    This article constitutes an extraction of key messages originally presented in the Document: Antimicrobials and Non-Healing Wounds. Evidence, controversies and suggestions written by the European Wound Management Association (EWMA), and originally published by the Journal of Wound Care in 2013. All sections are shortened and some not included. For further details please refer to in the original document which can be downloaded via www.ewma.org . PMID:25296348

  7. Controversial Physics: Perfect Public Outreach Opportunity

    NASA Astrophysics Data System (ADS)

    Thompson, Rebecca

    2012-03-01

    The goal of public outreach is to excite and engage the public in physics. What can be more exciting than controversy? When OPERA announced their discover of superluminal neutrinos, controversy within the physics community quickly followed. This result could overturn a century of established physics. From a public outreach perspective there was no better way to bring people usually unaware of current research into the discussion of this result. If handled well this could be used as a gateway to interest in other physics research. The public drive to learn more about this particular result can be harnessed to create interest in other cutting edge physics research and drive the public to continue their informal physics learning. If the results of OPERA and eventually proven incorrect as many physicists believe they will, that will not erase the public's new-found interest in physics but hopefully continue to fuel it.

  8. The European VLBI network

    NASA Technical Reports Server (NTRS)

    Schilizzi, R. T.

    1980-01-01

    The capabilities of the European very long baseline interferometry (VLBI) network are summarized. The range of baseline parameters, sensitivities, and recording and other equipment available are included. Plans for upgrading the recording facilities and the use of geostationary satellites for signal transfer and clock synchronization are discussed.

  9. Comment: An Apparent Controversy in Auroral Physics

    NASA Astrophysics Data System (ADS)

    Haerendel, Gerhard

    2007-03-01

    In his article ``A turning point in auroral physics,'' Bryant argued against what he called the `standard' theory of auroral acceleration, according to which the electrons ``gain their energy from static electric fields,'' and offered wave acceleration as an alternative. Because of the importance of the process, not only for the aurora borealis but also for other cosmic plasmas, a clarification of this apparent controversy seems to be in place.

  10. Controversies in faith and health care.

    PubMed

    Tomkins, Andrew; Duff, Jean; Fitzgibbon, Atallah; Karam, Azza; Mills, Edward J; Munnings, Keith; Smith, Sally; Seshadri, Shreelata Rao; Steinberg, Avraham; Vitillo, Robert; Yugi, Philemon

    2015-10-31

    Differences in religious faith-based viewpoints (controversies) on the sanctity of human life, acceptable behaviour, health-care technologies and health-care services contribute to the widespread variations in health care worldwide. Faith-linked controversies include family planning, child protection (especially child marriage, female genital mutilation, and immunisation), stigma and harm reduction, violence against women, sexual and reproductive health and HIV, gender, end-of-life issues, and faith activities including prayer. Buddhism, Christianity, Hinduism, Islam, Judaism, and traditional beliefs have similarities and differences in their viewpoints. Improved understanding by health-care providers of the heterogeneity of viewpoints, both within and between faiths, and their effect on health care is important for clinical medicine, public-health programmes, and health-care policy. Increased appreciation in faith leaders of the effect of their teachings on health care is also crucial. This Series paper outlines some faith-related controversies, describes how they influence health-care provision and uptake, and identifies opportunities for research and increased interaction between faith leaders and health-care providers to improve health care. PMID:26159392

  11. Sensitivity of advective transfer times across the North Atlantic Ocean to the temporal and spatial resolution of model velocity data: Implication for European eel larval transport

    NASA Astrophysics Data System (ADS)

    Blanke, Bruno; Bonhommeau, Sylvain; Grima, Nicolas; Drillet, Yann

    2012-05-01

    European eel (Anguilla anguilla) larvae achieve one of the longest larval migrations of the marine realm, i.e., more than 6000 km from their spawning grounds in the Sargasso Sea to European continental shelves. The duration of this migration remains debated, between 7 months and 3 years. This information is, however, crucial since it determines the period over which larvae are affected by environmental conditions and hence the subsequent recruitment success. We investigate the pathways and duration of trans-Atlantic connections using 3 years of high-resolution (daily, 1/12°) velocity fields available from a Mercator-Océan model configuration without data assimilation. We study specifically the effect of spatial and temporal resolutions on our estimates by applying various filters in time (from daily to 12-day averages) and space (from 1/12° to 1° gridcell aggregation) to the nominal model outputs. Numerical particles are released in the presumed European eel spawning area and considered as passive tracers at three specific depths (around 0, 50, and 200 m). We diagnose particularly the intensity of the water transfer between suitable control sections that encompass the eel larva distribution. Transit ages are also investigated, with a particular focus on the pathways that minimize the connection times between the western and eastern North Atlantic. We show that small-scale structures (eddies and filaments) contribute to faster connections though they also correspond to additional complexity in trajectories. The shortest pathways mostly follow the Gulf Stream and the North Atlantic Drift, whereas interior connections require longer transfers that prove less compatible with biological observations.

  12. Carbon monoxide (CO) and ethane (C2H6) trends from ground-based solar FTIR measurements at six European stations, comparison and sensitivity analysis with the EMEP model

    NASA Astrophysics Data System (ADS)

    Angelbratt, J.; Mellqvist, J.; Simpson, D.; Jonson, J. E.; Blumenstock, T.; Borsdorff, T.; Duchatelet, P.; Forster, F.; Hase, F.; Mahieu, E.; de Mazière, M.; Notholt, J.; Petersen, A. K.; Raffalski, U.; Servais, C.; Sussmann, R.; Warneke, T.; Vigouroux, C.

    2011-09-01

    Trends in the CO andC2H6 partial columns ~0-15 km) have been estimated from four European ground-based solar FTIR (Fourier Transform InfraRed) stations for the 1996-2006 time period. The CO trends from the four stations Jungfraujoch, Zugspitze, Harestua and Kiruna have been estimated to -0.45 ± 0.16% yr-1, -1.00 ± 0.24% yr-1, -0.62 ± 0.19 % yr-1 and -0.61 ± 0.16% yr-1, respectively. The corresponding trends for C2H6 are -1.51 ± 0.23% yr-1, -2.11 ± 0.30% yr-1, -1.09 ± 0.25% yr-1 and -1.14 ± 0.18% yr-1. All trends are presented with their 2-σ confidence intervals. To find possible reasons for the CO trends, the global-scale EMEP MSC-W chemical transport model has been used in a series of sensitivity scenarios. It is shown that the trends are consistent with the combination of a 20% decrease in the anthropogenic CO emissions seen in Europe and North America during the 1996-2006 period and a 20% increase in the anthropogenic CO emissions in East Asia, during the same time period. The possible impacts of CH4 and biogenic volatile organic compounds (BVOCs) are also considered. The European and global-scale EMEP models have been evaluated against the measured CO and C2H6 partial columns from Jungfraujoch, Zugspitze, Bremen, Harestua, Kiruna and Ny-Ålesund. The European model reproduces, on average the measurements at the different sites fairly well and within 10-22% deviation for CO and 14-31% deviation for C2H6. Their seasonal amplitude is captured within 6-35% and 9-124% for CO and C2H6, respectively. However, 61-98% of the CO and C2H6 partial columns in the European model are shown to arise from the boundary conditions, making the global-scale model a more suitable alternative when modeling these two species. In the evaluation of the global model the average partial columns for 2006 are shown to be within 1-9% and 37-50% of the measurements for CO and C2H6, respectively. The global model sensitivity for assumptions made in this paper is also analyzed.

  13. Early Controversies Over Athetosis: II. Treatment

    PubMed Central

    Lanska, Douglas J.

    2013-01-01

    Background Athetosis has been controversial since it was first described by William Hammond in 1871; many aspects of Hammond’s career were equally controversial. Methods Primary sources have been used to review treatment controversies in the 50-year period following the initial description of athetosis. Results The treatments used most commonly employed available pharmaceutical agents and modalities (e.g., galvanism). Initial anecdotal reports of success were seldom confirmed with subsequent experience. Several novel invasive therapies were also developed and promoted, all of which damaged or destroyed either upper or lower motor neuron pathways, and were also often associated with high mortality rates. In general, these therapies substituted paresis for abnormal spontaneous movements. These included peripheral nerve stretching, excision of a portion of the precentral gyrus, rhizotomy, nerve “transplantation” (i.e., neurotomy and nerve-to-nerve anastomoses), and “muscle group isolation” (i.e., alcohol neurolysis). There was no agreement on the appropriateness of such high-risk procedures, particularly given the intentional generation of further neurological morbidity. Discussion Pharmaceutical agents and modalities initially employed for athetosis had little a priori evidence-based justification and no biologically plausible theoretical framework to guide empiric treatment selection. Subsequently, all the invasive procedures employed were directed at lessening or removing the manifestations, rather than the underlying cause, of the abnormal central nervous system “irritation,” usually by imposing paresis or paralysis. Factors contributing to the disparity in outcomes between favorable initial reports and the often-disappointing results of later studies included reliance on anecdotal reports or small uncontrolled case series, placebo effects, biased observation, misdiagnosis, and biased reporting. PMID:23450199

  14. Extracorporeal life support: updates and controversies.

    PubMed

    Gadepalli, Samir K; Hirschl, Ronald B

    2015-02-01

    The use of Extracorporeal Life Support (ECLS) in children and adults has markedly increased during the past few years with over 4000 patients placed on ECLS every year in over 200 centers. This article focuses on updates to the physiology and mechanics of ECLS with use of magnetically levitated centrifugal pumps, hollow-fiber gas-exchange devices, and bi-caval dual-lumen catheters. We also explore controversies in management including indications, cannulation approaches, renal replacement, monitoring of anticoagulation, early ambulation, and termination of ECLS. Finally, we present changes in the systems that provide ECLS including the single-provider model and regionalization of care. PMID:25639803

  15. Retroperitoneal Sarcoma: Fact, Opinion, and Controversy.

    PubMed

    Gladdy, Rebecca A; Gupta, Abha; Catton, Charles N

    2016-10-01

    After diagnosis of retroperitoneal sarcoma (RPS), detailed imaging and multidisciplinary discussion should guide treatment including surgical resection and in select cases, neoadjuvant therapy. Local recurrence is common in RPS and is associated with grade, histologic subtype, completeness of resection, and size. As guidelines to standardize RPS patient management emerge, expert pathologic assessment and management in centers of excellence are benchmarks of quality of care. The efficacy of current chemotherapy is limited and there is a critical need to understand the molecular basis of sarcoma so that new drug therapies are developed. Multicenter clinical trials are needed to limit opinion and controversy in this complex and challenging disease. PMID:27591493

  16. Bioavailability of the Polyphenols: Status and Controversies

    PubMed Central

    D’Archivio, Massimo; Filesi, Carmelina; Varì, Rosaria; Scazzocchio, Beatrice; Masella, Roberta

    2010-01-01

    The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic compounds, and the most abundant ones in our diet are not necessarily those that have the best bioavailability profile. In the present review, we focus on the factors influencing the bioavailability of the polyphenols. Moreover, a critical overview on the difficulties and the controversies of the studies on the bioavailability is discussed. PMID:20480022

  17. Breast Cancer Screening Benefits: Research and Controversies.

    PubMed

    Odle, Teresa G

    2016-05-01

    The debate regarding the efficacy of breast cancer screening with mammography has intensified since about 2009, as the literature has reported on benefits, harms, and effectiveness of the technology in breast cancer diagnosis. As a result, women and their referring clinicians have been confused by conflicting reports in medical journals and the media. This article provides an overview of research and methodology used to generate these reports and the effects of contradictory research, screening recommendation changes, and the controversy over mammography efficacy on patients and the public. PMID:27146193

  18. Controversies in ureteroscopy: Wire, basket, and sheath

    PubMed Central

    Rizkala, Emad R; Monga, Manoj

    2013-01-01

    In the last one to two decades, flexible ureteroscopy has rapidly expanded its role in the treatment of urologic stone disease. With the frequent and expanded use of flexible ureteroscopy, other ancillary instruments were developed in order to ease and facilitate this technique, such as ureteral access sheaths (UAS) and a variety of wires and baskets. These developments, along with improved surgeon ureteroscopic competence, have often brought into question the need to implement the “traditional technique” of flexible ureteroscopy. In this review, we discuss a brief history of flexible ureteroscopy, its expanded indications, and the controversy surrounding the use of UAS, wires, and baskets. PMID:24082447

  19. Treatment of genital warts: facts and controversies.

    PubMed

    Wolf, Ronni; Davidovici, Batya

    2010-01-01

    There are two opposing approaches in the treatment of genital warts: (1) the traditional approach advocates complete elimination of all lesions, and (2) a second approach regards condyloma as merely a cosmetic nuisance. After a long journey through many arguments and scientific papers, we have concluded that many unknowns, uncertainties, and controversies concerning the value of treatment of genital warts in terms of clearing and curing the disease (ie, eradicating the viruses, preventing cancer, and reducing infectivity). There is no consensus at present of whether treatment of men with evidence of genital human papillomavirus infection influences the natural history of their female sex partner's cervical disease. PMID:20797516

  20. Intellectual property and information controversy (II)

    NASA Astrophysics Data System (ADS)

    Aoyama, Hirokazu

    As advanced information has been proceeded rapidly, intellectual property has become more important than ever as business resources of enterprises. Based on the former report by the author "present status of and trend in intellectual property" this paper describes "information" related intellectual property controversy which have been occurred, that is, 1) affairs related to computer hardwares and softwares (the case of compatible machines and OS, the case of application softwares, computer crimes) and 2) affairs on trade secret (the case of revealing enterprises'secret, the case of industrial espionage). It also discusses how intellectual property should be protected and utilized from now on.

  1. Distal radius fracture: diagnosis, treatment, and controversies.

    PubMed

    Tang, Jin Bo

    2014-07-01

    This article presents the diagnosis and treatment of distal radius fractures with emphasis on (1) current common principles, (2) the author's current practices, and (3) controversies. The author emphasizes that displaced distal radius fractures should be approached first with a trial of closed reduction, with or without percutaneous pinning. If this reduction is unstable or unsuccessful, open reduction is indicated. Early treatments include percutaneous pinning through the distal radioulnar joint, early or delayed reattachment/repair of the avulsed dorsal periphery of the triangular fibrocartilage complex (TFCC), reattachment of the TFCC to the ulna fovea, and late reconstruction. PMID:24996466

  2. Injectables in the Nose: Facts and Controversies.

    PubMed

    Thomas, William Walsh; Bucky, Lou; Friedman, Oren

    2016-08-01

    Nasal injectables and surface treatments alter the appearance of the nose both primarily and following nasal surgery. Fillers such as hyaluronic acids, calcium hydroxyapatite, and fat have a variety of advantages and disadvantages in eliminating small asymmetries postrhinoplasty. All nasal injectables have rare but severe ocular and cerebral ischemic complications. The injection of steroids following nasal reconstruction has a role in preventing supratip swelling and can improve the appearance of grafts to the nose. Resurfacing techniques reduce the appearance of autotransplanted grafts to the nose; there is little controversy about their benefit but surgeon preference for timing is varied. PMID:27400851

  3. Bioavailability of the polyphenols: status and controversies.

    PubMed

    D'Archivio, Massimo; Filesi, Carmelina; Varì, Rosaria; Scazzocchio, Beatrice; Masella, Roberta

    2010-01-01

    The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic compounds, and the most abundant ones in our diet are not necessarily those that have the best bioavailability profile. In the present review, we focus on the factors influencing the bioavailability of the polyphenols. Moreover, a critical overview on the difficulties and the controversies of the studies on the bioavailability is discussed. PMID:20480022

  4. Media Coverage and Public Opinion on Scientific Controversies.

    ERIC Educational Resources Information Center

    Mazur, Allan

    1981-01-01

    Examines the relationship of media coverage and public opinion in scientific controversy. A survey of coverage of controversies arising regarding sociobiology, water fluoridation, nuclear power and the Three Mile Island disaster indicates that the media play an active role in shaping and constructing controversy rather than just reporting it. (JMF)

  5. Creationism and Evolution: A Systems Perspective on a Textbook Controversy.

    ERIC Educational Resources Information Center

    Thompson, Patricia J.

    This paper addresses the effects of the controversies involved in one state's decision to exclude the study of evolution from its science curriculum and to require equal time for creationism as an alternative theory. Curricula and textbooks are examined for the impacts of evolutionary and creationist controversies. The controversy is discussed…

  6. Current Controversies With Recent Cholesterol Treatment Guidelines.

    PubMed

    Phillips, Elizabeth; Saseen, Joseph J

    2016-02-01

    Several guidelines and expert recommendations have been published recently regarding the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD) risk. The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend a drastic paradigm change in the treatment of cholesterol where treatment, based on level of cardiovascular risk, is based around using a fixed statin intensity therapy. This approach is endorsed by the American Diabetes Association. However, recommendations by the National Lipid Association (NLA) consist of the traditional approach of titrating therapy to achieve patient-specific lipoprotein targets. Despite the differences in overall approaches, the use of statin therapy as the cornerstone of treatment to reduce risk of cardiovascular events in at risk patients is a strong common theme. Clinicians should be aware of these differences, as they represent controversies with the overall treatment of ASCVD risk. Additional controversies related to the treatment of patients with ASCVD risk pertain to the role of nonstatin drugs and approaches to managing side effects. These topics are reviewed within this article and discuss implications for patient care. PMID:26611871

  7. Controversies in cancer pain. Medical perspectives.

    PubMed

    Foley, K M

    1989-06-01

    The treatment of pain in the patient with cancer has focused attention on a series of controversial issues involving medical, social, and moral factors. The medical factors include a lack of knowledge on the part of health care professionals regarding the rational use of opioid drugs. This is coupled with real limitations in the general understanding of the mechanisms of pain and its treatment using pharmacologic, anesthetic, and neurosurgical approaches. Several pharmacologic controversies, including the choice of drug, route and method of administration, and tolerance development and risk of substance abuse, have emerged with the use of opioids on a chronic basis in the cancer population. The social and moral implications involve the issue of who will pay for high technology pain management approaches for patients either at home or in hospice care and the ethical considerations in managing pain with opioid drugs. Carefully designed studies to assess these factors, coupled with broad educational programs, will improve the care of cancer patients in pain and expand our understanding of these important issues. PMID:2566369

  8. Glaciers in Patagonia: Controversy and prospects

    NASA Astrophysics Data System (ADS)

    Kargel, J. S.; Alho, P.; Buytaert, W.; Célleri, R.; Cogley, J. G.; Dussaillant, A.; Guido, Z.; Haeberli, W.; Harrison, S.; Leonard, G.; Maxwell, A.; Meier, C.; Poveda, G.; Reid, B.; Reynolds, J.; Rodríguez, C. A. Portocarrero; Romero, H.; Schneider, J.

    2012-05-01

    Lately, glaciers have been subjects of unceasing controversy. Current debate about planned hydroelectric facilities—a US7- to 10-billion megaproject—in a pristine glacierized area of Patagonia, Chile [Romero Toledo et al., 2009; Vince, 2010], has raised anew the matter of how glaciologists and global change experts can contribute their knowledge to civic debates on important issues. There has been greater respect for science in this controversy than in some previous debates over projects that pertain to glaciers, although valid economic motivations again could trump science and drive a solution to the energy supply problem before the associated safety and environmental problems are understood. The connection between glaciers and climate change—both anthropogenic and natural—is fundamental to glaciology and to glaciers' practical importance for water and hydropower resources, agriculture, tourism, mining, natural hazards, ecosystem conservation, and sea level [Buytaert et al., 2010; Glasser et al., 2011]. The conflict between conservation and development can be sharper in glacierized regions than almost anywhere else. Glaciers occur in spectacular natural landscapes, but they also supply prodigious exploitable meltwater.

  9. Sugar substitutes: Health controversy over perceived benefits

    PubMed Central

    Tandel, Kirtida R.

    2011-01-01

    Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener) is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, animal studies have convincingly proven that artificial sweeteners cause weight gain, brain tumors, bladder cancer and many other health hazards. Some kind of health related side effects including carcinogenicity are also noted in humans. A large number of studies have been carried out on these substances with conclusions ranging from “safe under all conditions” to “unsafe at any dose”. Scientists are divided in their views on the issue of artificial sweetener safety. In scientific as well as in lay publications, supporting studies are often widely referenced while the opposing results are de-emphasized or dismissed. So this review aims to explore the health controversy over perceived benefits of sugar substitutes. PMID:22025850

  10. Bleeding Avoidance Strategies: Consensus and Controversy

    PubMed Central

    Dauerman, Harold L.; Rao, Sunil V.; Resnic, Frederic S.; Applegate, Robert J.

    2011-01-01

    Bleeding complications after coronary intervention are associated with prolonged hospitalization, increased hospital costs, patient dissatisfaction, morbidity and one year mortality. Bleeding Avoidance Strategies represent a term incorporating multiple modalities that aim to reduce bleeding and vascular complications after cardiovascular catheterization. Recent improvements in the rates of bleeding complications after invasive cardiovascular procedures suggests that the clinical community has successfully embraced specific strategies and improved patient care in this area. There remains controversy regarding the efficacy, safety and/or practicality of 3 key bleeding avoidance strategies for cardiac catheterization and coronary intervention: procedural (radial artery approach, safezone arteriotomy), pharmacologic (multiple agents) and technological (vascular closure devices) approaches to improved access. In this article, we address areas of consensus with respect to selected modalities in order to define the role of each strategy in current practice. Furthermore, we focus on areas of controversy for selected modalities in order to define key areas warranting cautious clinical approaches and the need for future randomized clinical trials in this area. PMID:21700085

  11. Breast cancer screening: controversy of impact.

    PubMed

    Berry, Donald A

    2013-08-01

    Few medical issues have been as controversial--or as political, at least in the United States-as the role of mammographic screening for breast cancer. The advantages of finding a cancer early seem obvious. Indeed, randomized trials evaluating screening mammography demonstrate a reduction in breast cancer mortality, but the benefits are less than one would hope. Moreover, the randomized trials are themselves subject to criticism, including that they are irrelevant in the modern era because most were conducted before chemotherapy and hormonal therapy became widely used. In this article I chronicle the evidence and controversies regarding mammographic screening, including attempts to assess the relative contributions of screening and therapy in the substantial decreases in breast cancer mortality that have been observed in many countries over the last 20-25 years. I emphasize the trade-off between harms and benefits depending on the woman's age and other risk factors. I also discuss ways for communicating the associated risks to women who have to decide whether screening (and what screening strategy) is right for them. PMID:24074796

  12. Gardnerella vaginalis: characteristics, clinical considerations, and controversies.

    PubMed Central

    Catlin, B W

    1992-01-01

    The clinical significance, Gram stain reaction, and genus affiliation of Gardnerella vaginalis have been controversial since Gardner and Dukes described the organism as the cause of "nonspecific vaginitis," a common disease of women which is now called bacterial vaginosis. The organism was named G. vaginalis when taxonomic studies showed that it was unrelated to bacteria in various genera including Haemophilus and Corynebacterium. Electron microscopy and chemical analyses have elucidated the organism's gram-variable reaction. Controversy over the etiology of bacterial vaginosis was largely resolved by (i) studies using improved media and methods for the isolation and identification of bacteria in vaginal fluids and (ii) standardization of criteria for clinical and laboratory diagnosis. Besides G. vaginalis, Mobiluncus spp., Mycoplasma hominis, and certain obligate anaerobes are now acknowledged as participants in bacterial vaginosis. The finding that G. vaginalis, Mobiluncus spp., and M. hominis inhabit the rectum indicates a potential source of autoinfection in addition to sexual transmission. Extravaginal infections with G. vaginalis are increasingly recognized, especially when the toxic anticoagulant polyanetholesulfonate is omitted from blood cultures and when urine cultures are incubated anaerobically for 48 h. The finding that mares harbor G. vaginalis suggests that an equine model can be developed for studies of Gardnerella pathogenesis. Images PMID:1498765

  13. Impact of chemical and meteorological boundary and initial conditions on air quality modeling: WRF-Chem sensitivity evaluation for a European domain

    NASA Astrophysics Data System (ADS)

    Ritter, Mathias; Müller, Mathias D.; Jorba, Oriol; Parlow, Eberhard; Liu, L.-J. Sally

    2013-01-01

    This study evaluates the impact of different chemical and meteorological boundary and initial conditions on the state-of-the-art Weather Research and Forecasting (WRF) model with its chemistry extension (WRF-Chem). The evaluation is done for July 2005 with 50 km horizontal resolution. The effect of monthly mean chemical boundary conditions derived from the chemical transport model LMDZ-INCA on WRF-Chem is evaluated against the effect of the preset idealized profiles. Likewise, the impact of different meteorological initial and boundary conditions (GFS and Reanalysis II) on the model is evaluated. Pearson correlation coefficient between these different runs range from 0.96 to 1.00. Exceptions exists for chemical boundary conditions on ozone and for meteorological boundary conditions on PM10, where coefficients of 0.90 were obtained. Best results were achieved with boundary and initial conditions from LMDZ-INCA and GFS. Overall, the European simulations show encouraging results for observed air pollutant, with ozone being the most and PM10 being the least satisfying.

  14. European Mistletoe

    MedlinePlus

    ... gov Key References American mistletoe. Natural Medicines Comprehensive Database Web site. Accessed at www.naturaldatabase.com on July 7, 2009. European mistletoe. Natural Medicines Comprehensive Database Web site. Accessed at www.naturaldatabase.com on July ...

  15. European Community.

    PubMed

    1987-05-01

    The European Community was established in 1951 to reconcile France and Germany after World War II and to make possible the eventual federation of Europe. By 1986, there were 12 member countries: France, Italy, Belgium, the Federal Republic of Germany, Luxembourg, the Netherlands, Denmark, Ireland, the United Kingdom, Greece, Spain, and Portugal. Principal areas of concern are internal and external trade, agriculture, monetary coordination, fisheries, common industrial and commercial policies, assistance, science and research, and common social and regional policies. The European Community has a budget of US$34.035 billion/year, funded by customs duties and 1.4% of each member's value-added tax. The treaties establishing the European Community call for members to form a common market, a common customs tariff, and common agricultural, transport, economic, and nuclear policies. Major European Community institutions include the Commission, Council of Ministers, European Parliament, Court of Justice, and Economic and Social Committee. The Community is the world's largest trading unit, accounting for 15% of world trade. The 2 main goals of the Community's industrial policy are to create an open internal market and to promote technological innovation in order to improve international competitiveness. The European Community aims to contribute to the economic and social development of Third World countries as well. PMID:12177941

  16. Controversies Surrounding Classification of Personality Disorder

    PubMed Central

    Tyrer, Peter

    2010-01-01

    Nowadays, it is apparent that personality disorder is a common condition. Some of the concepts of personality disorder that are currently in use are flawed and need to be revised. The aim of this article is to discuss the controversy created by the uncertainties in the current classification system and to suggest ways forward. In particular, the clinician needs to be aware of the importance of assessing personality abnormality in terms of a severity dimension, and of the ways in which such an abnormality can impact on treatments for other conditions. These changes in the notion of personality disorder are needed as, for the first time, a good evidence base is being established for potential treatments and these will be maximized if we have a classification fit for therapeutic purpose. PMID:20396426

  17. Current questions and possible controversies in autophagy

    PubMed Central

    Lindqvist, L M; Simon, A K; Baehrecke, E H

    2015-01-01

    Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may ‘switch’ its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field. PMID:26682061

  18. Lung Cancer—Current Concepts and Controversies

    PubMed Central

    Pett, Stuart B.; Wernly, Jorge A.; Akl, Bechara F.

    1986-01-01

    The recent literature contains a variety of controversial management alternatives for patients with pulmonary malignancy that affect all aspects of the lung cancer problem. Revisions in the classification system have been advanced in which the prognostic implications of specific ultrastructural and histochemical information are acknowledged. Computed tomography and, to a lesser extent, nuclide scanning have revolutionized the staging process, but limitations in these procedures are emerging. Improved survival following aggressive surgical treatment has challenged the adequacy of the standard staging system. The palliative role of radiotherapy is becoming more widely appreciated. Results of immunotherapy are equivocal and gains from chemotherapy are modest. Combinations of treatment modalities will require further documentation before they can be recommended with confidence. PMID:3529632

  19. The dental amalgam controversy: a review

    PubMed Central

    Feuer, George; Injeyan, H Stephen

    1996-01-01

    In spite of the long history of mercury amalgam as a dental restorative material, its use continues to be controversial. Mercury vapour is continuously released from dental amalgam and is ultimately absorbed into a variety of tissues. Experimental data have demonstrated that the uptake, tissue retention and excretion of mercury from dental amalgam is significant. Evidence has accumulated indicating a relationship between tissue mercury levels and a multitude of clinical manifestations. However, the clinical significance of mercury toxicity from dental amalgams is a matter for debate. The literature is devoid of randomized clinical trials that are rigorously designed to address this issue. Thus, although research data renders the notion of amalgam safety questionable, the dental community appears determined to continue its use as long as unequivocal evidence correlating amalgam mercury toxicity to specific clinical conditions is lacking.

  20. Epistemological depth in a GM crops controversy.

    PubMed

    Hicks, Daniel J

    2015-04-01

    This paper examines the scientific controversy over the yields of genetically modified [GM] crops as a case study in epistemologically deep disagreements. Appeals to "the evidence" are inadequate to resolve such disagreements; not because the interlocutors have radically different metaphysical views (as in cases of incommensurability), but instead because they assume rival epistemological frameworks and so have incompatible views about what kinds of research methods and claims count as evidence. Specifically, I show that, in the yield debate, proponents and opponents of GM crops cite two different sets of claims as evidence, which correspond to two rival epistemological frameworks, classical experimental epistemology and Nancy Cartwright's evidence for use. I go on to argue that, even if both sides of the debate accepted Cartwright's view, they might still disagree over what counts as evidence, because evidence for use ties standards of evidence to what is sometimes called the "context of application." PMID:25768981

  1. [Oswaldo Cruz and the serology controversy].

    PubMed

    Carreta, Jorge Augusto

    2011-01-01

    This analysis of the discussion surrounding the efficacy of the plague serum produced by Manguinhos Institute in the early twentieth century begins with an overview of Oswaldo Cruz's service as head of the Public Health Directorship (Diretoria de Saúde Pública). The controversy itself is then addressed, through an exploration of correspondence exchanged by physicians Oswaldo Cruz, Miguel Pereira, Vital Brazil, Chapot Prévost, and Francisco Fajardo. Their letters reveal how bacteriology in Brazil was then marked by uncertainty and experimentation, even while this field of knowledge publicly touted itself as safe and incontestable. The article shows how arguments of an extra-scientific nature interfere with both research development and the acceptance of medical products. PMID:22012092

  2. Element 74, the Wolfram Versus Tungsten Controversy

    SciTech Connect

    Holden,N.E.

    2008-08-11

    Two and a quarter centuries ago, a heavy mineral ore was found which was thought to contain a new chemical element called heavy stone (or tungsten in Swedish). A few years later, the metal was separated from its oxide and the new element (Z=74) was called wolfram. Over the years since that time, both the names wolfram and tungsten were attached to this element in various countries. Sixty years ago, IUPAC chose wolfram as the official name for the element. A few years later, under pressure from the press in the USA, the alternative name tungsten was also allowed by IUPAC. Now the original, official name 'wolfram' has been deleted by IUPAC as one of the two alternate names for the element. The history of this controversy is described here.

  3. Cross-Platform Evaluation of Commercial Real-Time SYBR Green RT-PCR Kits for Sensitive and Rapid Detection of European Bat Lyssavirus Type 1

    PubMed Central

    Picard-Meyer, Evelyne; Peytavin de Garam, Carine; Schereffer, Jean Luc; Marchal, Clotilde; Robardet, Emmanuelle; Cliquet, Florence

    2015-01-01

    This study evaluates the performance of five two-step SYBR Green RT-qPCR kits and five one-step SYBR Green qRT-PCR kits using real-time PCR assays. Two real-time thermocyclers showing different throughput capacities were used. The analysed performance evaluation criteria included the generation of standard curve, reaction efficiency, analytical sensitivity, intra- and interassay repeatability as well as the costs and the practicability of kits, and thermocycling times. We found that the optimised one-step PCR assays had a higher detection sensitivity than the optimised two-step assays regardless of the machine used, while no difference was detected in reaction efficiency, R2 values, and intra- and interreproducibility between the two methods. The limit of detection at the 95% confidence level varied between 15 to 981 copies/µL and 41 to 171 for one-step kits and two-step kits, respectively. Of the ten kits tested, the most efficient kit was the Quantitect SYBR Green qRT-PCR with a limit of detection at 95% of confidence of 20 and 22 copies/µL on the thermocyclers Rotor gene Q MDx and MX3005P, respectively. The study demonstrated the pivotal influence of the thermocycler on PCR performance for the detection of rabies RNA, as well as that of the master mixes. PMID:25785274

  4. Cross-platform evaluation of commercial real-time SYBR green RT-PCR kits for sensitive and rapid detection of European bat Lyssavirus type 1.

    PubMed

    Picard-Meyer, Evelyne; Peytavin de Garam, Carine; Schereffer, Jean Luc; Marchal, Clotilde; Robardet, Emmanuelle; Cliquet, Florence

    2015-01-01

    This study evaluates the performance of five two-step SYBR Green RT-qPCR kits and five one-step SYBR Green qRT-PCR kits using real-time PCR assays. Two real-time thermocyclers showing different throughput capacities were used. The analysed performance evaluation criteria included the generation of standard curve, reaction efficiency, analytical sensitivity, intra- and interassay repeatability as well as the costs and the practicability of kits, and thermocycling times. We found that the optimised one-step PCR assays had a higher detection sensitivity than the optimised two-step assays regardless of the machine used, while no difference was detected in reaction efficiency, R (2) values, and intra- and interreproducibility between the two methods. The limit of detection at the 95% confidence level varied between 15 to 981 copies/µL and 41 to 171 for one-step kits and two-step kits, respectively. Of the ten kits tested, the most efficient kit was the Quantitect SYBR Green qRT-PCR with a limit of detection at 95% of confidence of 20 and 22 copies/µL on the thermocyclers Rotor gene Q MDx and MX3005P, respectively. The study demonstrated the pivotal influence of the thermocycler on PCR performance for the detection of rabies RNA, as well as that of the master mixes. PMID:25785274

  5. Behavioral sensitivity of the European blind cave salamander, Proteus anguinus, and a Pyrenean newt, Euproctus asper, to electrical fields in water.

    PubMed

    Schlegel, P A

    1997-01-01

    In the urodeles Proteus anguinus and Euproctus asper, thresholds of an overt avoidance response to weak electrical field stimuli (continuous sine-waves) were measured as a function of frequency. Thresholds down to 0.1 mV/cm (30 nA/cm2) were found in P. anguinus and 2 mV/cm (600 nA/cm2) in E. asper at 'best frequencies' (B.F.) of 20-30 Hz, but sensitivity covered a total frequency range of below 0.1 Hz to 1-2 kHz, with up to 70 dB higher thresholds. Average thresholds of 1 mV/cm in P. anguinus and 40 mV/cm in E. asper were more than 30 dB apart and significantly different. Both species were sensitive to galvanic DC-pulses, clicks, and noise bursts with intensities of about the same order of magnitude. Specimens of the transparent catfish, Kryptopterus (Siluridae) reacted in the same frequency range as found for Proteus and Euproctus, and had still lower thresholds, down to 0.02 mV/cm (1.5 nA/cm2). The biological significance and possibly still ongoing evolution of the electrical sense in urodeles is interpreted in terms of comparative sensory physiology and more recent, still speculative, evolutionary diversification during and since the Pleistocene. PMID:9063590

  6. Sensitivity of June Near-Surface Temperatures and Precipitation in the Eastern United States to Historical Land Cover Changes Since European Settlement

    NASA Technical Reports Server (NTRS)

    Strack, John E.; Pielke, Roger A.; Steyaert, Louis T.; Knox, Robert G.

    2008-01-01

    Land cover changes alter the near surface weather and climate. Changes in land surface properties such as albedo, roughness length, stomatal resistance, and leaf area index alter the surface energy balance, leading to differences in near surface temperatures. This study utilized a newly developed land cover data set for the eastern United States to examine the influence of historical land cover change on June temperatures and precipitation. The new data set contains representations of the land cover and associated biophysical parameters for 1650, 1850, 1920, and 1992, capturing the clearing of the forest and the expansion of agriculture over the eastern United States from 1650 to the early twentieth century and the subsequent forest regrowth. The data set also includes the inferred distribution of potentially water-saturated soils at each time slice for use in the sensitivity tests. The Regional Atmospheric Modeling System, equipped with the Land Ecosystem-Atmosphere Feedback (LEAF-2) land surface parameterization, was used to simulate the weather of June 1996 using the 1992, 1920, 1850, and 1650 land cover representations. The results suggest that changes in surface roughness and stomatal resistance have caused present-day maximum and minimum temperatures in the eastern United States to warm by about 0.3 C and 0.4 C, respectively, when compared to values in 1650. In contrast, the maximum temperatures have remained about the same, while the minimums have cooled by about 0.1 C when compared to 1920. Little change in precipitation was found.

  7. The Spokane flood controversy and the Martian outflow channels

    NASA Technical Reports Server (NTRS)

    Baker, V. R.

    1978-01-01

    The controversy over Bretz's hypothesis concerning the cataclysmic Spokane flood is discussed. Attention is directed to similarities between the Channeled Scabland of Washington and some Martian land features considered to be catastrophic flood channels. Characteristics of the enormous plexus of proglacial stream channels eroded into the loess and basalt of the Columbia Plateau in eastern Washington are described. The controversiality of the suggestion that a catastrophic flood is responsible for the Martian features is considered with respect to the Spokane flood controversy.

  8. Sensitivity of June near-surface temperatures and precipitation in the eastern United States to historical land cover changes since European settlement

    USGS Publications Warehouse

    Strack, J.E.; Pielke, R.A., Sr.; Steyaert, L.T.; Knox, R.G.

    2008-01-01

    Land cover changes alter the near surface weather and climate. Changes in land surface properties such as albedo, roughness length, stomatal resistance, and leaf area index alter the surface energy balance, leading to differences in near surface temperatures. This study utilized a newly developed land cover data set for the eastern United States to examine the influence of historical land cover change on June temperatures and precipitation. The new data set contains representations of the land cover and associated biophysical parameters for 1650, 1850, 1920, and 1992, capturing the clearing of the forest and the expansion of agriculture over the eastern United States from 1650 to the early twentieth century and the subsequent forest regrowth. The data set also includes the inferred distribution of potentially water-saturated soils at each time slice for use in the sensitivity tests. The Regional Atmospheric Modeling System, equipped with the Land Ecosystem-Atmosphere Feedback (LEAF-2) land surface parameterization, was used to simulate the weather of June 1996 using the 1992, 1920, 1850, and 1650 land cover representations. The results suggest that changes in surface roughness and stomatal resistance have caused present-day maximum and minimum temperatures in the eastern United States to warm by about 0.3??C and 0.4??C, respectively, when compared to values in 1650. In contrast, the maximum temperatures have remained about the same, while the minimums have cooled by about 0.1??C when compared to 1920. Little change in precipitation was found. Copyright 2008 by the American Geophysical Union.

  9. LDL cholesterol: controversies and future therapeutic directions.

    PubMed

    Ridker, Paul M

    2014-08-16

    Lifelong exposure to raised concentrations of LDL cholesterol increases cardiovascular event rates, and the use of statin therapy as an adjunct to diet, exercise, and smoking cessation has proven highly effective in reducing the population burden associated with hyperlipidaemia. Yet, despite consistent biological, genetic, and epidemiological data, and evidence from randomised trials, there is controversy among national guidelines and clinical practice with regard to LDL cholesterol, its measurement, the usefulness of population-based screening, the net benefit-to-risk ratio for different LDL-lowering drugs, the benefit of treatment targets, and whether aggressive lowering of LDL is safe. Several novel therapies have been introduced for the treatment of people with genetic defects that result in loss of function within the LDL receptor, a major determinant of inherited hyperlipidaemias. Moreover, the usefulness of monoclonal antibodies that extend the LDL-receptor lifecycle (and thus result in substantial lowering of LDL cholesterol below the levels achieved with statins alone) is being assessed in phase 3 trials that will enrol more than 60,000 at-risk patients worldwide. These trials represent an exceptionally rapid translation of genetic observations into clinical practice and will address core questions of how low LDL cholesterol can be safely reduced, whether the mechanism of LDL-cholesterol lowering matters, and whether ever more aggressive lipid-lowering provides a safe, long-term mechanism to prevent atherothrombotic complications. PMID:25131980

  10. More on SUPPORT: the controversy continues.

    PubMed

    Macklin, Ruth

    2015-01-01

    The article by Sunita VS Bandewar in the January-March issue does an excellent job of describing the controversy over informed consent in the SUPPORT clinical trial. As one of the authors of the duelling articles Bandewar cites, I commend the author's conclusions calling for disclosure not only of randomisation in so-called "standard of care" clinical trials, but also the comprehensive disclosure of risks in this type of research (also known as "comparative effectiveness research [CER]"). Bandewar surmises that the disclosure of randomisation could result in a "much higher chance of patients declining to participate in a randomised trial"; and that this may be one of the motives of those who argue for non-disclosure of randomisation. In fact, at least some supporters of limited disclosure of the risks in CER trials have expressly acknowledged their concerns about the recruitment of participants if all the risks of "standard of care" treatments are mentioned in the consent forms. PMID:25910283

  11. World bank in AIDS prevention controversy.

    PubMed

    James, J S

    1995-06-16

    A controversial editorial review article on AIDS prevention by researchers at the Center for AIDS Prevention Studies (CAPS) of the University of California was recently published in the British journal, AIDS. The article's thesis is that in addition to individual behavior, social and economic forces have played a role in promoting the spread of HIV in developing countries, where, by the year 2000, 90 percent of HIV infection will have occurred. The researchers argue that an economic approach, called structural adjustment programs [begun and spearheaded by the International Monetary Fund (IMF) and the World Bank], may have created conditions favoring the spread of HIV infection. The article is concerned about four alleged consequences of these programs: the decline of rural subsistence economy; the development of a transportation infrastructure; migration and urbanization; and reduced spending on health and social services. The CAPS authors recommend changes in development programs which focus on the satisfaction of basic human needs and movement from paternalistic to cooperative development policy. They suggest changing the charter of the World Bank and IMF to allow rescheduling or canceling of debt. World Bank officials, in letters to AIDS, tried to persuade the journal not to publish the article, citing that it falls below the journal's current standards and that some of the information is wrong. PMID:11362526

  12. Maxillary reconstruction: Current concepts and controversies

    PubMed Central

    Iyer, Subramania; Thankappan, Krishnakumar

    2014-01-01

    Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. The defects of maxilla apart from affecting the functions of the speech, swallowing and mastication also cause cosmetic disfigurement. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Literature is abundant with a variety of reconstructive methods. The classification systems are also varied, with no universal acceptance of any one of them. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Management of the orbit is also not yet addressed properly. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. This review article discusses the rationale and oncological safety of the reconstructing the maxillary defects, critically analyzes the classification systems, offers the different reconstructive methods and touches upon the controversies in this subject. The management of the retained and exenterated orbit associated with maxillectomy is reviewed. The surgical morbidity, complications and the recent advances in this field are also looked into. An algorithm, based on our experience, is presented. PMID:24987199

  13. Cytomegalovirus and glioblastoma; controversies and opportunities.

    PubMed

    Lawler, Sean E

    2015-07-01

    One of the more polarized ongoing debates in the brain tumor field over recent years has centered on the association of cytomegalovirus (CMV) with glioblastoma. Several laboratories have reported the presence of CMV antigens in glioblastoma patient specimens, whereas others have failed to detect them. CMV genomic DNA and mRNAs have been detected by PCR, but not in next-generation sequencing studies. CMV promotes high grade glioma progression in a mouse genetic model, and many CMV proteins promote cancer hallmarks in vitro, but actively replicating virus has not been isolated from tumor samples. A consensus is gradually emerging in which the presence of CMV antigens in glioblastoma is increasingly accepted. However, it remains challenging to understand this mechanistically due to the low levels of CMV nucleic acids and the absence of viral replication observed in tumors thus far. Nonetheless, these observations have inspired the development of novel therapeutic approaches based on anti-viral drugs and immunotherapy. The potential benefit of valganciclovir in glioblastoma has generated great interest, but efficacy remains to be established in a randomized trial. Also, early stage immunotherapy trials targeting CMV have shown promise. In the near future we will know more answers to these questions, and although areas of controversy may remain, and the mechanisms and roles of CMV in tumor growth are yet to be clearly defined, this widespread virus may have created important new therapeutic concepts and opportunities for the treatment of glioblastoma. PMID:25682092

  14. Controversies in proton therapy for prostate cancer.

    PubMed

    Bryant, Curtis; Henderson, Randal H; Hoppe, Bradford S; Mendenhall, William M; Nichols, R Charles; Su, Zhong; Li, Zuofeng; Mendenhall, Nancy P

    2016-08-01

    Proton therapy (PT) for prostate cancer has been a subject of controversy over the past two decades. Because of its dosimetric advantages when compared to conventional radiation, PT has the potential to improve the therapeutic ratio in the management of prostate cancer by decreasing toxicity and improving disease control. Nevertheless, its higher costs and the current lack of level I evidence documenting improved clinical outcomes have led some to question its cost-effectiveness. A number of new PT centers have been built over the past decade, leading many stakeholders, including patients, physicians, and insurers, to demand comparative effectiveness data to support its current use. In this review, we summarize the results of recently published studies that support the safety and efficacy of PT in the treatment of prostate cancer. We also review the available cost-effectiveness data for PT and discuss the future of PT, including the current randomized trial comparing PT to intensity-modulated radiation therapy and the need for additional research that may help to establish the relative benefit of PT when compared to photon-based radiation therapy. PMID:27558255

  15. Phytosynthesis of nanoparticles: concept, controversy and application

    NASA Astrophysics Data System (ADS)

    Husen, Azamal; Siddiqi, Khwaja Salahuddin

    2014-05-01

    Nanotechnology is an exciting and powerful discipline of science; the altered properties of which have offered many new and profitable products and applications. Agriculture, food and medicine sector industries have been investing more in nanotechnology research. Plants or their extracts provide a biological synthesis route of several metallic nanoparticles which is more eco-friendly and allows a controlled synthesis with well-defined size and shape. The rapid drug delivery in the presence of a carrier is a recent development to treat patients with nanoparticles of certain metals. The engineered nanoparticles are more useful in increasing the crop production, although this issue is still in infancy. This is simply due to the unprecedented and unforeseen health hazard and environmental concern. The well-known metal ions such as zinc, iron and copper are essential constituents of several enzymes found in the human system even though the indiscriminate use of similar other metal nanoparticle in food and medicine without clinical trial is not advisable. This review is intended to describe the novel phytosynthesis of metal and metal oxide nanoparticles with regard to their shape, size, structure and diverse application in almost all fields of medicine, agriculture and technology. We have also emphasized the concept and controversial mechanism of green synthesis of nanoparticles.

  16. Endoscopic vein harvesting: technique, outcomes, concerns & controversies

    PubMed Central

    Sarang, Zubair

    2013-01-01

    The choice of the graft conduit for coronary artery bypass grafting (CABG) has significant implications both in the short- and long-term. The patency of a coronary conduit is closely associated with an uneventful postoperative course, better long-term patient survival and superior freedom from re-intervention. The internal mammary artery is regarded as the primary conduit for CABG patients, given its association with long-term patency and survival. However, long saphenous vein (LSV) continues to be utilized universally as patients presenting for CABG often have multiple coronary territories requiring revascularization. Traditionally, the LSV has been harvested by creating incisions from the ankle up to the groin termed open vein harvesting (OVH). However, such harvesting methods are associated with incisional pain and leg wound infections. In addition, patients find such large incisions to be cosmetically unappealing. These concerns regarding wound morbidity and patient satisfaction led to the emergence of endoscopic vein harvesting (EVH). Published experience comparing OVH with EVH suggests decreased wound related complications, improved patient satisfaction, shorter hospital stay, and reduced postoperative pain at the harvest site following EVH. Despite these reported advantages concerns regarding risk of injury at the time of harvest with its potential detrimental effect on vein graft patency and clinical outcomes have prevented universal adoption of EVH. This review article provides a detailed insight into the technical aspects, outcomes, concerns, and controversies associated with EVH. PMID:24251019

  17. Phytosynthesis of nanoparticles: concept, controversy and application

    PubMed Central

    2014-01-01

    Nanotechnology is an exciting and powerful discipline of science; the altered properties of which have offered many new and profitable products and applications. Agriculture, food and medicine sector industries have been investing more in nanotechnology research. Plants or their extracts provide a biological synthesis route of several metallic nanoparticles which is more eco-friendly and allows a controlled synthesis with well-defined size and shape. The rapid drug delivery in the presence of a carrier is a recent development to treat patients with nanoparticles of certain metals. The engineered nanoparticles are more useful in increasing the crop production, although this issue is still in infancy. This is simply due to the unprecedented and unforeseen health hazard and environmental concern. The well-known metal ions such as zinc, iron and copper are essential constituents of several enzymes found in the human system even though the indiscriminate use of similar other metal nanoparticle in food and medicine without clinical trial is not advisable. This review is intended to describe the novel phytosynthesis of metal and metal oxide nanoparticles with regard to their shape, size, structure and diverse application in almost all fields of medicine, agriculture and technology. We have also emphasized the concept and controversial mechanism of green synthesis of nanoparticles. PMID:24910577

  18. Current Controversies in Lung Cancer Staging.

    PubMed

    Carter, Brett W; Godoy, Myrna C B; Wu, Carol C; Erasmus, Jeremy J; Truong, Mylene T

    2016-07-01

    Lung cancer remains the leading cause of cancer-related mortality in the United States, and accurate staging of disease plays an important role in the formulation of treatment strategies and optimization of patient outcomes. The International Association for the Study of Lung Cancer has recently proposed changes to the upcoming eighth edition of the tumor, node, and metastasis (TNM-8) staging system used for lung cancer. This revised classification is based on significant differences in patient survival identified on analysis of a new large international database of lung cancer cases. Key changes include: further modifications to the T descriptors based on 1 cm increments in tumor size; grouping of tumors resulting in partial or complete lung atelectasis/pneumonitis; grouping of tumors involving a main bronchus with respect to distance from the carina; reassignment of diaphragmatic invasion; elimination of mediastinal pleural invasion as a descriptor; and further subdivision of metastatic disease into distinct descriptors based on the number of extrathoracic metastases and involved organs. Because of these changes, several new stage groups have been developed, and others have shifted. Although TNM-8 represents continued improvement upon modifications previously made to the staging system, reflecting an evolving understanding of tumor behavior and patient management, several limitations and unaddressed issues persist. Understanding the proposed revisions to TNM-8 and awareness of key limitations and potential controversial issues still unaddressed will allow radiologists to accurately stage patients with lung cancer and optimize treatment decisions. PMID:27306388

  19. Obestatin: an interesting but controversial gut hormone.

    PubMed

    Lacquaniti, Antonio; Donato, Valentina; Chirico, Valeria; Buemi, Antoine; Buemi, Michele

    2011-01-01

    Obestatin is a 23-amino acid peptide hormone released from the stomach and is present not only in the gastrointestinal tract, but also in the spleen, mammary gland, breast milk and plasma. Obestatin appears to function as part of a complex gut-brain network whereby hormones and substances from the stomach and intestines signal the brain about satiety or hunger. In contrast to ghrelin, which causes hyperphagia and obesity, obestatin appears to act as an anorectic hormone, decreasing food intake and reducing body weight gain. Further studies have shown that obestatin is also involved in improving memory, regulating sleep, affecting cell proliferation, increasing the secretion of pancreatic juice enzymes and inhibiting glucose-induced insulin secretion. This hormone has not only been studied in the field of physiology but also in the fields of obesity and diabetes mellitus, and in patients with psychogenic eating disorders. Obestatin has a role in regulating the cell cycle by exerting proliferative effects that may be seen in cell physiology and oncology. Given the current controversy regarding the effects of obestatin and its cognate ligand, this article provides the latest review of the physiological and pathological characteristics of this hormone. PMID:22156552

  20. Publication of Controversial Papers in Life.

    PubMed

    Lin, Shu-Kun

    2012-01-01

    Life (ISSN 2075-1729, http://www.mdpi.com/journal/life/) is a new journal that deals with new and sometime difficult interdisciplinary matters. Consequently, the journal will occasionally be presented with submitted articles that are controversial and/or outside conventional scientific views. Some papers recently accepted for publication in Life have attracted significant attention. Moreover, members of the Editorial Board have objected to these papers; some have resigned, and others have questioned the scientific validity of the contributions. In response I want to first state some basic facts regarding all publications in this journal. All papers are peer-reviewed, although it is often difficult to obtain expert reviewers for some of the interdisciplinary topics covered by this journal. I feel obliged to stress that although we will strive to guarantee the scientific standard of the papers published in this journal, all the responsibility for the ideas contained in the published articles rests entirely on their authors. Discussions on previously published articles are welcome and I hope that, by fostering discussion and by keeping an open-minded attitude towards new ideas, the journal will spur progress in this little explored, difficult and very exciting area of knowledge. [...]. PMID:26791663

  1. Maxillary reconstruction: Current concepts and controversies.

    PubMed

    Iyer, Subramania; Thankappan, Krishnakumar

    2014-01-01

    Maxillary reconstruction is still an evolving art when compared to the reconstruction of the mandible. The defects of maxilla apart from affecting the functions of the speech, swallowing and mastication also cause cosmetic disfigurement. Rehabilitation of the form and function in patients with maxillary defects is either by using an obturator prosthesis or by a surgical reconstruction. Literature is abundant with a variety of reconstructive methods. The classification systems are also varied, with no universal acceptance of any one of them. The oncologic safety of these procedures is still debated, and conclusive evidence in this regard has not emerged yet. Management of the orbit is also not yet addressed properly. Tissue engineering, that has been hyped to be one of the possible solutions for this vexing reconstructive problem, has not come out with reliable and reproducible results so far. This review article discusses the rationale and oncological safety of the reconstructing the maxillary defects, critically analyzes the classification systems, offers the different reconstructive methods and touches upon the controversies in this subject. The management of the retained and exenterated orbit associated with maxillectomy is reviewed. The surgical morbidity, complications and the recent advances in this field are also looked into. An algorithm, based on our experience, is presented. PMID:24987199

  2. Microsurgical free flaps: Controversies in maxillofacial reconstruction

    PubMed Central

    George, Rinku K.; Krishnamurthy, Arvind

    2013-01-01

    Reconstructive microsurgery for oral and maxillofacial (OMF) defects is considered as a niche specialty and is performed regularly only in a handful of centers. Till recently the pectoralis major myocutaneous flap (PMMC) was considered to be the benchmark for OMF reconstruction. This philosophy is changing fast with rapid advancement in reconstructive microsurgery. Due to improvement in instrumentation and the development of finer techniques of flap harvesting we can positively state that microsurgery has come of age. Better techniques, microscopes and micro instruments enable us to do things previously unimaginable. Supramicrosurgery and ultrathin flaps are a testimony to this. Years of innovation in reconstructive microsurgery have given us a reasonably good number of very excellent flaps. Tremendous work has been put into producing some exceptionally brilliant research articles, sometimes contradicting each other. This has led to the need for clarity in some areas in this field. This article will review some controversies in reconstructive microsurgery and analyze some of the most common microvascular free flaps (MFF) used in OMF reconstruction. It aims to buttress the fact that three flaps-the radial forearm free flap (RFFF), anterolateral thigh flap (ALT) and fibula are the ones most expedient in the surgeon's arsenal, since they can cater to almost all sizeable defects we come across after ablative surgery in the OMF region. They can thus aptly be titled as the workhorses of OMF reconstruction with regard to free flaps. PMID:23662264

  3. Neutron bomb and European defense

    SciTech Connect

    Sweet, W.

    1980-08-15

    France's development of the controversial neutron bomb is in line with the US goal of flexible response to a Soviet threat in Europe. US neutron bomb production is on a standby basis pending agreement among the North Atlantic Treaty Organization (NATO) members for deployment. Controversy over the bomb centers on its anti-personnel nature, which many see as immoral in comparison with weapons that primarily damage property. Opponents also see it as lowering the nuclear threshold and increasing the chance of nuclear war. Supporters view the bomb as a tactical weapon to be used on a limited scale as a last resort. If Germany's Chancellor Schmidt fails to negotiate a limit to European nuclear arms deployment with the Soviet Union, neutron-bomb production in the US and France will most likely proceed. The prospects for including European nuclear weapons in the Strategic Arms Limitation Talks (SALT) III are jeopardized by the Soviet invasion of Afghanistan and the failure of an early SALT II ratification. 17 references. (DCK)

  4. Research controversies in management of oral mucositis.

    PubMed

    Biron, P; Sebban, C; Gourmet, R; Chvetzoff, G; Philip, I; Blay, J Y

    2000-01-01

    The management of mucositis is the subject of many controversies, and the optimal treatment is still not known. Several evaluation scoring systems have been described, but no one of these is appropriate to all clinical situations: a simple scale such as that devised by the WHO can be used routinely, and more sophisticated ones can be implemented by trained experimenters working in research. We have considered the impact of each of the treatments currently available on each stage of mucositis. In attempts at prevention, self-care, in the sense of oral hygiene, must remain atraumatic. It is probably advisable to differentiate patients with good previous oral care, in whom tooth brushing is beneficial, from others, in whom the risk of hemorrhage and infection excludes any brushing. Before the dosage of chemotherapy is reduced, the curative or palliative intent of the strategy must be carefully evaluated. In the vascular phase protection of the proliferating cells is attempted by means of vasoconstriction (cryotherapy), cytoprotection (prostaglandin E2 and other antioxidants) or epithelial cell-inhibiting factors such as TGF-B3. Treatments applied in the epithelial phase are directed at increasing the cell proliferation to accelerate epithelial restoration by sucralfate and several growth factors: hematopoietic GF, which has demonstrated a direct effect on the mucosa (GM-CSF), or epithelial growth factors such as keratinocyte GF. In the ulcerative and bacteriological phase attempts are made to attenuate sepsis by means of antiseptics (chlorhexidine), amphotericin B and antiviral agents or antibiotic lozenges. In the healing phase application of the low-energy helium-neon laser has demonstrably been followed by a later time of onset, less pronounced peak severity and shorter duration of oral mucositis. After cancer treatment, oral hygiene, inhibition of oral flora, and pain relief are the main goals. Physiopathogen-specific treatment is the next step, with the emphasis

  5. Cold dark matter: Controversies on small scales.

    PubMed

    Weinberg, David H; Bullock, James S; Governato, Fabio; Kuzio de Naray, Rachel; Peter, Annika H G

    2015-10-01

    The cold dark matter (CDM) cosmological model has been remarkably successful in explaining cosmic structure over an enormous span of redshift, but it has faced persistent challenges from observations that probe the innermost regions of dark matter halos and the properties of the Milky Way's dwarf galaxy satellites. We review the current observational and theoretical status of these "small-scale controversies." Cosmological simulations that incorporate only gravity and collisionless CDM predict halos with abundant substructure and central densities that are too high to match constraints from galaxy dynamics. The solution could lie in baryonic physics: Recent numerical simulations and analytical models suggest that gravitational potential fluctuations tied to efficient supernova feedback can flatten the central cusps of halos in massive galaxies, and a combination of feedback and low star formation efficiency could explain why most of the dark matter subhalos orbiting the Milky Way do not host visible galaxies. However, it is not clear that this solution can work in the lowest mass galaxies, where discrepancies are observed. Alternatively, the small-scale conflicts could be evidence of more complex physics in the dark sector itself. For example, elastic scattering from strong dark matter self-interactions can alter predicted halo mass profiles, leading to good agreement with observations across a wide range of galaxy mass. Gravitational lensing and dynamical perturbations of tidal streams in the stellar halo provide evidence for an abundant population of low-mass subhalos in accord with CDM predictions. These observational approaches will get more powerful over the next few years. PMID:25646464

  6. Blastocystis: Consensus of treatment and controversies

    PubMed Central

    Sekar, Uma; Shanthi, M

    2013-01-01

    Blastocystis is a highly controversial protozoan parasite. It has been variably regarded as a commensal and pathogen. Scientists have for decades wondered whether it is truly an enteropathogen and if it is observed in symptomatic patients whether treatment is required because patient recovery and improvement has been noted even without any treatment. Though associated with self-limiting infection, treatment is warranted in many patients due to persistence of symptoms. This particularly holds true for children and adults who are immuno compromised. Several drugs have been used to treat Blastocystis but each one of them has produced widely variable rates of clinical cure and eradication of the parasite from the feces. Based on the studies carried out in vitro and clinical responses obtained in patients, metronidazole appears to be the most effective drug for Blastocystis infection. However, the therapy is complicated due to different dosages and regimens adopted and the unresponsiveness to treatment observed in several sections of the population studied. Recently, the finding of different subsets of Blastocystis exhibiting resistance to metronidazole and associated with variable degrees of symptoms has underscored the importance of typing the subsets of the parasite in order to foretell the clinical response and the need to treat. Till date, the mode of action of the drugs used and the mechanism of resistance is not entirely known and is a topic of speculation. Other drugs with anti Blastocystis activity and used in therapy includes trimethoprim sulfamethoxazole and nitazoxanide. Several other compounds have also been evaluated for the treatment either alone or in combination with the first or second line drugs. A lot of interest has also been generated on the role of probiotics particularly Saccharomyces boularrdii and other natural food compounds on eradication of the parasite. This review provides a comprehensive overview of antimicrobials used to target

  7. The Gaia Controversy: AGU'S Chapman Conference

    NASA Astrophysics Data System (ADS)

    Kauffman, Eric G.

    The controversial Gaia Hypothesis of James Lovelock of Coombe Mill, Launceston, Cornwall, U.K., and his colleagues variously contends that throughout Earth history the global biosphere has influenced, even controlled, the physicochemical evolution of Earth's environments (especially oceans and climate) for its own benefit. Since the origin of life, the biosphere has influenced selective pressures on evolution, maintained the Earth in a kind of homeostasis, and thus created an environmental optimum through time, regulated by and for the biosphere. Rarely has a hypothesis immediately sparked such passionate response. There is something in it for everybody, from hard core scientists to philosophers, ultraconservationists, students of world religions, mystics, politicians, and space enthusiasts; they were all there in San Diego, March 7-11, 1988, for the AGU Chapman Conference on Gaia Hypotheses. For 4 days an impressive list of specialists presented and debated the pros and cons of Gaia Hypotheses from diverse perspectives: modern and ancient biology, ecology, biochemistry, the physicochemical systems of the Earth, oceans, and atmosphere, and the evolution of the solar system. Focus was on modern to Pleistocene atmosphere-ocean-Earth systems, case histories of their interaction with the biosphere, and relatively simple models drawn from these observations and projected back through time. Equivalent studies on the geological and paleobiological history of the Earth-life system over the past 3.5 b.y. were underrepresented. Extended debates that followed generally strong presentations were lively, argumentative, and remarkably civil despite widely held views. The grace with which Jim Lovelock moved between his strongest critics and supporters set high standards for the debates. Everybody acknowledged a high learning curve.

  8. Cold dark matter: Controversies on small scales

    PubMed Central

    Weinberg, David H.; Bullock, James S.; Governato, Fabio; Kuzio de Naray, Rachel; Peter, Annika H. G.

    2015-01-01

    The cold dark matter (CDM) cosmological model has been remarkably successful in explaining cosmic structure over an enormous span of redshift, but it has faced persistent challenges from observations that probe the innermost regions of dark matter halos and the properties of the Milky Way’s dwarf galaxy satellites. We review the current observational and theoretical status of these “small-scale controversies.” Cosmological simulations that incorporate only gravity and collisionless CDM predict halos with abundant substructure and central densities that are too high to match constraints from galaxy dynamics. The solution could lie in baryonic physics: Recent numerical simulations and analytical models suggest that gravitational potential fluctuations tied to efficient supernova feedback can flatten the central cusps of halos in massive galaxies, and a combination of feedback and low star formation efficiency could explain why most of the dark matter subhalos orbiting the Milky Way do not host visible galaxies. However, it is not clear that this solution can work in the lowest mass galaxies, where discrepancies are observed. Alternatively, the small-scale conflicts could be evidence of more complex physics in the dark sector itself. For example, elastic scattering from strong dark matter self-interactions can alter predicted halo mass profiles, leading to good agreement with observations across a wide range of galaxy mass. Gravitational lensing and dynamical perturbations of tidal streams in the stellar halo provide evidence for an abundant population of low-mass subhalos in accord with CDM predictions. These observational approaches will get more powerful over the next few years. PMID:25646464

  9. Screening for cancer: concepts and controversies.

    PubMed

    Gates, Thomas J

    2014-11-01

    Early detection of cancer is a core task in family medicine, and patients have come to expect screening tests, sometimes out of proportion to what evidence can justify. To understand the controversies surrounding screening and to provide sound advice to patients, family physicians should be familiar with the fundamental concepts of screening. Failure to account for the effects of lead-time, length-time, and overdiagnosis biases can lead to overestimation of screening benefits. For this reason, the best method for evaluating the benefit of screening tests is a randomized controlled trial showing decreased disease-specific or all-cause mortality. The number needed to screen can be used to measure the magnitude of benefit of screening tests. Accepted screening tests often require screening several hundred to more than 1,000 asymptomatic patients to prevent one death from the disease. The U.S. Preventive Services Task Force and American Academy of Family Physicians recommend screening for colorectal cancer in adults 50 to 75 years of age, and recommend against prostate-specific antigen testing to screen for prostate cancer. Annual low-dose computed tomography screening for lung cancer reduces mortality in persons 55 to 80 years of age with at least a 30-pack-year history who are otherwise healthy smokers or who have quit smoking within the past 15 years; however, it is associated with a high false-positive rate, uncertain harms from radiation exposure, and overdiagnosis. Therefore, it should be performed only in conjunction with smoking cessation interventions. PMID:25368922

  10. Codeine in paediatrics: pharmacology, prescribing and controversies.

    PubMed

    Andrzejowski, Paul; Carroll, Will

    2016-06-01

    Codeine is a drug that until recently was widely used in children. It was endorsed by the WHO as the second step on the analgesic ladder for cancer pain and has been used routinely for postoperative and breakthrough pain. Recently, its safety and efficacy have been called into question, following deaths after adenotonsillectomy was associated with its use. This has led to regulation by the US Food and Drug Administration, European Medicines Agency and the UK Medicines and Healthcare products Regulatory Agency to place significant restrictions on its use, and some centres have stopped using it altogether.In this article, we discuss the developmental pharmacology underpinning its action, reviewing what is known about the pharmacokinetics, pharmacodynamics and pharmacogenetics in children, how this relates to prescribing, as well as the practical issues and the recent regulatory framework surrounding its use. PMID:26984558

  11. The NSF Science Education Controversy: Issues, Events, Decisions.

    ERIC Educational Resources Information Center

    Wiley, Karen B.

    Discussion of National Science Foundation (NSF) funding of precollege science education revolves around the controversy of whether NSF should fund "Man: A Course of Study" (MACOS). NSF had funded MACOS' curriculum development, implementation, and postevaluation during 1963-1975. The controversy began in March 1975 when U.S. Congressman John Conlan…

  12. Approaching Civic Responsibility Using Guided Controversies about Environmental Issues

    ERIC Educational Resources Information Center

    Dresner, Marion; Blatner, Jen Seamans

    2006-01-01

    We implemented a series of three guided controversies to provide experience in environmental problem solving to students in a science course designed for nonmajors. Students wrote essays in response to their experiences in each controversy; we analyzed these essays for five problem-solving criteria. A questionnaire administered at the end of the…

  13. Improving Learning by Discussing Controversies in 20th Century Physics.

    ERIC Educational Resources Information Center

    Niaz, Mansoor; Rodriguez, Maria A.

    2002-01-01

    Textbooks rarely emphasize how controversial some physics theories were at the time of their proposal. Makes the case that useful classroom debate can be generated by considering the controversy that arose over models of the atom such as Rutherford's and Bohr's, and ideas about fractional charges put forward by Millikan and arising from quark…

  14. Teachers' Perspectives on Incorporating Current Controversial Issues into the Curriculum.

    ERIC Educational Resources Information Center

    Wilson, Elizabeth; Sunal, Cynthia; Haas, Mary; Laughlin, Margaret

    Does a current controversial issue become part of the social studies curriculum in a context where the media focus largely on the issue? A study explored this question through surveys and in-depth interviews that investigated K-12 social studies teachers' perspectives on the incorporation of current controversial issues into the curriculum. A…

  15. Literature for Children: Avoiding Controversy and Intellectual Challenge.

    ERIC Educational Resources Information Center

    Adams, Dennis M.

    1986-01-01

    Discusses lack of literature on controversial subjects that can help prepare children and young adults to deal perceptively with complexities of modern world. Highlights include meeting the issues head-on, glorifying armed conflict in video media, avoiding issues of nuclear war, and intellectual depth and dealing with controversial issues. (12…

  16. Structured Academic Controversies in the Professional Physical Education Classroom.

    ERIC Educational Resources Information Center

    Overby, Lynnette Young; And Others

    1996-01-01

    Structured academic controversy is a cooperative learning strategy that can promote learning in theoretical physical education classes at the college level. This article explains how to conduct structured academic controversy, providing examples of topics (e.g., adapted physical education, biomechanics, motor development, and sport psychology).…

  17. Tennessee to Texas: Tracing the Evolution Controversy in Public Education

    ERIC Educational Resources Information Center

    Armenta, Tony; Lane, Kenneth E.

    2010-01-01

    Darwin's Theory of Evolution has stirred controversy since its inception. Public schools in the United States, pressed by special interest groups on both sides of the controversy, have struggled with how best to teach the theory, if at all. Court cases have dealt with whether states can ban the teaching of evolutionary theory, whether Creationism…

  18. Covering Conflict and Controversy: Measuring Balance, Fairness, Defamation.

    ERIC Educational Resources Information Center

    Simon, Todd F.; And Others

    1989-01-01

    Measures balance, fairness, and defamation in local stories containing controversy and covering law enforcement, education, local government, and business. Finds that most stories lack balance and that the opposing side of the controversy was not contacted in 28 percent of the instances. (RS)

  19. What's Wrong with the "Teach the Controversy" Slogan?

    ERIC Educational Resources Information Center

    Scott, Eugenie C.

    2007-01-01

    Teachers are often exhorted by creationists to "teach the controversy." Although such encouragement sounds on the surface like a proposal for critical thinking instruction, the history of the creationist movement in North America belies this claim. Rather than teach students to analyze and evaluate actual scientific controversies, the intent of…

  20. Main Field Test Report. Discussing Controversial Issues. Revised.

    ERIC Educational Resources Information Center

    Lai, Morris K.; And Others

    Discussing Controversial Issues (DCI) is a skill training program designed for high school students and teachers with an overall objective of developing student and teacher skill in discussing controversial issues effectively. The course materials identify 13 moderator techniques which teachers practice, and 13 participant techniques which…

  1. The Procedurally Directive Approach to Teaching Controversial Issues

    ERIC Educational Resources Information Center

    Gregory, Maughn Rollins

    2014-01-01

    Recent articles on teaching controversial topics in schools have employed Michael Hand's distinction between "directive teaching," in which teachers attempt to persuade students of correct positions on topics that are not rationally controversial, and "nondirective teaching," in which teachers avoid persuading students on…

  2. Visualizing Social Justice: Using Controversial Images in Social Studies Classrooms

    ERIC Educational Resources Information Center

    Hawley, Todd S.; Crowe, Alicia R.; Mooney, Evan

    2016-01-01

    In this article, we promote the use of controversial images to enhance the discussion of social justice issues in schools. Controversial images provide rich opportunities for students to question what is occurring currently in society as well as what has occurred in the past. We provide an example set of activities to be used in teacher education…

  3. Culture Shock: Using Art and Art Controversy To Teach History.

    ERIC Educational Resources Information Center

    McBride, Robert, Jr.

    1999-01-01

    Endorses the television series entitled "Culture Shock" that views controversial art as an artifact suggesting that the arts, and controversies surrounding them, can help viewers think critically about the issues of past and present societies. Focuses on "The Adventures of Huckleberry Finn," the painting "Olympia," jazz, and films in the…

  4. Urquhart's and Garfield's Laws: The British Controversy over Their Validity.

    ERIC Educational Resources Information Center

    Bensman, Stephen J.

    2001-01-01

    The British controversy over the validity of Urquhart's and Garfield's bibliometric laws during the 1970s constitutes an important episode in the formulation of the probability structure of human knowledge. Concludes with a resolution of the controversy by means of a statistical technique that incorporates Brookes' criticism of the Spearman…

  5. 16 CFR 2.3 - Policy as to private controversies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... other action when the alleged violation of law is merely a matter of private controversy and does not... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy as to private controversies. 2.3... NONADJUDICATIVE PROCEDURES Inquiries; Investigations; Compulsory Processes § 2.3 Policy as to...

  6. Implants and Ethnocide: Learning from the Cochlear Implant Controversy

    ERIC Educational Resources Information Center

    Sparrow, Robert

    2010-01-01

    This paper uses the fictional case of the "Babel fish" to explore and illustrate the issues involved in the controversy about the use of cochlear implants in prelinguistically deaf children. Analysis of this controversy suggests that the development of genetic tests for deafness poses a serious threat to the continued flourishing of Deaf culture.…

  7. Resisting the Pendulum Swing: Informed Perspectives on Education Controversies.

    ERIC Educational Resources Information Center

    Jalongo, Mary Renck, Ed.

    Designed to offer more than slogans and buzzwords to practitioners who are grappling with an array of education controversies, this book provides classroom teachers with a spectrum of information about current controversies so that they will be better equipped to blend action with reflection. The book deliberately resists extremes and argues for…

  8. Teaching and Learning about Controversial Issues: Lessons from Northern Ireland

    ERIC Educational Resources Information Center

    King, John T.

    2009-01-01

    Teaching about controversial issues is a powerful tool in the repertoire of civic educators. Despite widespread agreement concerning the social, academic, and civic benefits to be gained from discussing controversial public issues within the classroom, empirical research reveals that doing so is a rare occurrence. While the literature explains…

  9. Preparing Students for Science in the Face of Social Controversy

    ERIC Educational Resources Information Center

    Bramschreiber, Terry; Westmoreland, David

    2015-01-01

    Science educators often teach topics that are largely resolved in the scientific community yet remain controversial in broader society. In such cases, students may perceive the teacher as biased. We present two exercises that foster more objective learning about the scientific underpinnings of socially controversial topics. The first exercise…

  10. The Recovered Memory Controversy: A Representative Case Study

    ERIC Educational Resources Information Center

    Colangelo, James J.

    2009-01-01

    The recovered memory controversy has been an ongoing debate within the mental health profession for the past two decades. Disagreement remains in the field over the veracity of "forgotten" memories of childhood sexual abuse that are recalled or recovered during therapy. At the heart of the controversy are the concepts of repression and…

  11. 12 CFR 1080.3 - Policy as to private controversies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Policy as to private controversies. 1080.3 Section 1080.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION RULES RELATING TO INVESTIGATIONS § 1080.3 Policy as to private controversies. The Bureau shall act only in the public interest and...

  12. 12 CFR 1080.3 - Policy as to private controversies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Policy as to private controversies. 1080.3 Section 1080.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION RULES RELATING TO INVESTIGATIONS § 1080.3 Policy as to private controversies. The Bureau shall act only in the public interest and...

  13. The Rasch Rating Model and the Disordered Threshold Controversy

    ERIC Educational Resources Information Center

    Adams, Raymond J.; Wu, Margaret L.; Wilson, Mark

    2012-01-01

    The Rasch rating (or partial credit) model is a widely applied item response model that is used to model ordinal observed variables that are assumed to collectively reflect a common latent variable. In the application of the model there is considerable controversy surrounding the assessment of fit. This controversy is most notable when the set of…

  14. From Classroom to Controversy: Conflict in the Teaching of Religion

    ERIC Educational Resources Information Center

    Neal, Lynn S.

    2013-01-01

    What happens when a class assignment becomes a source of controversy? How do we respond? What do we learn? By describing the controversy surrounding an assignment on religion and representation, this article examines conflict's productive role in teaching about New Religious Movements (NRMs) and religion. It suggests that we consider how our…

  15. Controversial Higher-Education Reforms Spark Riots in Athens

    ERIC Educational Resources Information Center

    Labi, Aisha

    2007-01-01

    This article discusses the Greek Parliament's controversial education bill passed recently that sparked riots and unrest in Athens. The government's controversial education package includes measures that would limit the number of years students can take to complete a university degree and would curtail university asylum laws. A separate proposal…

  16. Controversy and the state: lord ARPA and intelligent computing.

    PubMed

    Guice, J

    1998-02-01

    This is a study of a well-known controversy in computer science, between artificial intelligence and neural networks researchers. It examines claims made by participants in the field that the controversy was triggered, shaped and finally resolved in connection to activities of state research agencies, particularly the US Department of Defense Advanced Research Projects Agency (ARPA). In contrast to these claims, this account concludes that, although ARPA's relations to the controversy among researchers were important, they were indirect. This study thus beings the analytical resources of studies of scientific controversy to bear on a domain which has so far gone largely unexamined in studies of 20th-century controversies - namely, state research policy and management. The account is based on contemporary documents, historical literatuare, and interviews with researchers and ARPA officials. PMID:11619937

  17. Why Map Issues? On Controversy Analysis as a Digital Method

    PubMed Central

    2015-01-01

    This article takes stock of recent efforts to implement controversy analysis as a digital method in the study of science, technology, and society (STS) and beyond and outlines a distinctive approach to address the problem of digital bias. Digital media technologies exert significant influence on the enactment of controversy in online settings, and this risks undermining the substantive focus of controversy analysis conducted by digital means. To address this problem, I propose a shift in thematic focus from controversy analysis to issue mapping. The article begins by distinguishing between three broad frameworks that currently guide the development of controversy analysis as a digital method, namely, demarcationist, discursive, and empiricist. Each has been adopted in STS, but only the last one offers a digital “move beyond impartiality.” I demonstrate this approach by analyzing issues of Internet governance with the aid of the social media platform Twitter. PMID:26336325

  18. KNOW NUKES: a model for teaching controversial issues

    SciTech Connect

    Thomashow, M.S.

    1986-01-01

    This dissertation articulates elements of an educational strategy derived from the experience of the KNOW NUKES program, a teacher training project designed to introduce the nuclear power controversy in the high school classroom. This strategy can be used as means of furthering the effectiveness of controversial issues education, not only in the area of nuclear power, but in teaching about any environmental issue. This is specifically achieved by (2) placing the KNOW NUKES institute in the broader context of controversial issues education; (2) describing in detail KNOW NUKES project planning; (3) reviewing the structure and content of the various teaching techniques and materials that have been developed for the KNOW NUKES institute; (4) utilizing a particular technique developed by the institute that reveals varying perspectives on controversial issues, in this case, an instrumental for decoding the controversial issues that are explicit and implicit in corporate image advertisements; and (5) qualitatively evaluating the practical implementation of the KNOW NUKES model.

  19. Nonpalpable thyroid carcinoma: clinical controversies on preoperative selection.

    PubMed

    Carpi, Angelo; Nicolini, Andrea; Casara, Dario; Rubello, Domenico; Rosa Pelizzo, Maria

    2003-06-01

    This article emphasizes some controversies concerning the preoperative selection of nonpalpable thyroid tumors. The prevalence of occult thyroid carcinoma in surgical series (1.8-10%) is not higher than in autopsy thyroid series (2.7-24%). The prevalence of occult thyroid carcinoma in thyroid glands examined in the same institution by ultrasound, for a clinical thyroid abnormality or for investigation of other neck structures without clinically evident or suspected thyroid disease, varies from 3% to 8% and is very similar independent of the fact that a thyroid abnormality is or is not the indication for ultrasonography. These data suggest that the presence of a thyroid disease is not a risk factor for harboring an occult thyroid carcinoma (except for C-cell hyperplasia in the rare case of MEN 2 syndromes). As it is not cost effective to examine all the nonpalpable lesions with fine-needle aspiration (FNA) guided by ultrasounds, it is necessary to define to which extent ultrasound is useful in selecting those lesions to be examined cytologically by FNA. The use of ultrasound to select these lesions is very controversial. Ultrasound-guided cytologic diagnosis of nonpalpable nodules is not as accurate as in the case of palpable nodules. Sampling of material adequate for cytologic analysis depends on the lesion size; it is 64% for a 0.7-cm lesion and it increases to 86.7% for a mean size of 1.1 cm. For the diagnosis of occult thyroid carcinomas (< or =1 cm), sensitivity is 35.8% and false-negative results are 49.3%. Nonpalpable nodules with a size of 1.5 cm represent an absolute indication to perform an ultrasound-guided FNA because this is the size limit for dividing thyroid nodules in probably innocuous or potentially dangerous categories and because the cytologic diagnosis of nodules of this size is sufficiently reliable. For the smaller incidentally discovered thyroid nodules following ultrasound, physicians should discuss with the patient whether and when to

  20. The Neogene: Origin, adoption, evolution, and controversy

    NASA Astrophysics Data System (ADS)

    Walsh, Stephen L.

    2008-07-01

    Some stratigraphers have recently insisted that for historical reasons, the Neogene (Miocene + Pliocene) should be extended to the present. However, despite some ambiguity in its application by Moriz Hörnes in the 1850s, the "Neogene" was widely adopted by European geologists to refer to the Miocene and Pliocene of Lyell, but excluding the "Diluvium" (later to become the Pleistocene) and "Alluvium" (later to become the Holocene). During the late 19th and early 20th centuries, the ends of the Neogene, Tertiary and Pliocene evolved in response to the progressive lowering of the beginnings of the Quaternary and Pleistocene. This evolution was a logical result of the widespread views that the most recent "ice ages" were worthy of recognition as a formal unit of the standard geologic time scale, and that the structure of this time scale must be strictly hierarchical. Motivations for the extension of the Neogene to the present include the desire to establish a monopoly for marine biochronology in the definition of standard global chronostratigraphic boundaries. This agenda would also eliminate the Tertiary, Quaternary, and Holocene. These changes are unnecessary. There is every reason to retain the traditional hierarchical structure of the Cenozoic time scale.

  1. Friends or Relatives? Phylogenetics and Species Delimitation in the Controversial European Orchid Genus Ophrys

    PubMed Central

    Devey, Dion S.; Bateman, Richard M.; Fay, Michael F.; Hawkins, Julie A.

    2008-01-01

    Background and Aims Highly variable, yet possibly convergent, morphology and lack of sequence variation have severely hindered production of a robust phylogenetic framework for the genus Ophrys. The aim of this study is to produce this framework as a basis for more rigorous species delimitation and conservation recommendations. Methods Nuclear and plastid DNA sequencing and amplified fragment length polymorphism (AFLP) were performed on 85 accessions of Ophrys, spanning the full range of species aggregates currently recognized. Data were analysed using a combination of parsimony and Bayesian tree-building techniques and by principal co-ordinates analysis. Key Results Complementary phylogenetic analyses and ordinations using nuclear, plastid and AFLP datasets identify ten genetically distinct groups (six robust) within the genus that may in turn be grouped into three sections (treated as subgenera by some authors). Additionally, genetic evidence is provided for a close relationship between the O. tenthredinifera, O. bombyliflora and O. speculum groups. The combination of these analytical techniques provides new insights into Ophrys systematics, notably recognition of the novel O. umbilicata group. Conclusions Heterogeneous copies of the nuclear ITS region show that some putative Ophrys species arose through hybridization rather than divergent speciation. The supposedly highly specific pseudocopulatory pollination syndrome of Ophrys is demonstrably ‘leaky’, suggesting that the genus has been substantially over-divided at the species level. PMID:18184645

  2. DNA from herbarium specimens settle a long-held controversy about origins of the European potato

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Landrace potato cultivars (Solanum tuberosum L.) are native to two areas in South America: the high Andes from Venezuela to Argentina, and the lowlands of south-Central Chile. Potato first appeared in Europe in 1567, and rapidly diffused worldwide. Two competing hypotheses have suggested the origin ...

  3. DNA from herbarium specimens settles a controversy about origins of the European potato

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Landrace cultivars of potato, Solanum tuberosum, are widely distributed in the mid to high elevations of the Andes from Venezuela south to northern Argentina, and then with a break in distribution in the lowlands of central Chile in Chiloé Island and the Chonos Archipelago immediately to the south. ...

  4. The controversial age of Kilimanjaro's plateau glaciers

    NASA Astrophysics Data System (ADS)

    Uglietti, Chiara; Zapf, Alexander; Szidat, Sönke; Salazar, Gary; Hardy, Doug; Schwikowski, Margit

    2015-04-01

    Interpreting climate signals contained in natural archives requires a precise chronology. Radiocarbon analysis can be a powerful tool for dating high-altitude ice cores, especially for the lowermost segments for which ice flow-induced thinning limits the counting of annual layers. Radiocarbon dating has been applied to ice cores containing sufficient organic material, which is a limiting factor to the wider application of this technique. We present a novel radiocarbon dating approach using carbonaceous aerosols enclosed in the ice to help resolve the debate about the age of the Kilimanjaro's plateau glaciers. Paleoclimate reconstructions based on six ice cores drilled in 2000 assigned a basal age of 11'700 years. A recent study claims recurring cycles of waxing and waning controlled primarily by atmospheric moisture and an absence of the ice bodies was suggested for 1200 AD. The Kilimanjaro ice fields are subject to rapid areal shrinkage and thinning and are expected to disappear within several decades. Resolving the controversy of the time frame for the extinction of the Kilimanjaro ice might have wide implications for the understanding of the natural climate variability in the tropics. A stratigraphic sequence of samples from the exposed vertical ice cliffs at the margins of the Northern Ice Field (NIF) was collected in 2011. A total of 45 horizontal short cores (50 cm length) were extracted from 22 horizons characterized by varying micro-particle concentrations. Additionally, 3 samples were taken from the glacier surface to investigate a potential age offset. All samples were shipped frozen to Paul Scherrer Institute, decontaminated in a cold room by removing the outer layer (0.3 mm) and by rinsing the samples with ultra-pure water. The insoluble carbonaceous particles were filtrated by using freshly preheated quartz fibre filters. Procedural blanks were estimated using artificial ice blocks of frozen ultra-pure water treated as real ice samples and were

  5. Participation rate or informed choice? Rethinking the European key performance indicators for mammography screening.

    PubMed

    Strech, Daniel

    2014-03-01

    Despite the intensive controversies about the likelihood of benefits and harms of mammography screening almost all experts conclude that the choice to screen or not to screen needs to be made by the individual patient who is adequately informed. However, the "European guideline for quality assurance in breast cancer screening and diagnosis" specifies a participation rate of 70% as the key performance indicator for mammography screening. This paper argues that neither the existing evidence on benefits and harms, nor survey research with women, nor compliance rates in clinical trials, nor cost-effectiveness ratios justify participation rates as a reasonable performance indicator for preference-sensitive condition such as mammography screening. In contrast, an informed choice rate would be more reasonable. Further research needs to address the practical challenges in assessing informed choice rates. PMID:24332817

  6. Borderline viability: controversies in caring for the extremely premature infant.

    PubMed

    Leuthner, Steven R

    2014-12-01

    Controversy surrounding the decision to resuscitate at the limits or borderline of viability has been at the center of neonatal ethical debate for decades. This debate has led to numerous reports from individual institutions, councils, and advisory committees that all have remarkable consistency in the development of gestational age-based guidelines. This article reviews legal or regulatory concerns that may contradict ethical discussion and guidelines, discriminatory and scientific basis concerns with consensus guidelines, and personal controversy about how to determine best interest. Guidelines are a reasonable place to start in helping determine parental authority and autonomy. The article also addresses controversies raised in counseling and costs. PMID:25459775

  7. Controversies in the Management of Papillary Thyroid Cancer Revisited

    PubMed Central

    Guerrero, Marlon A.; Clark, Orlo H.

    2011-01-01

    The debate on the appropriate treatment of patients with papillary thyroid cancer (PTC) has persisted for several decades. The main controversies focus on the extent of surgery, the timing of central neck dissection, and the indications for radioactive iodine ablation. These controversies continue, for the most part, due to the good prognosis of PTC patients and the questionable effect these treatment modalities have on patient survival. This paper addresses these three controversies and the role of molecular tumor markers in the appropriate treatment selection. PMID:22091417

  8. Addressing controversies in science education: a pragmatic approach to evolution education

    NASA Astrophysics Data System (ADS)

    Hildebrand, David; Bilica, Kimberly; Capps, John

    2008-09-01

    Science education controversies typically prove more intractable than those in scientific research because they involve a wider range of considerations (e.g., epistemic, social, ethical, political, and religious). How can educators acknowledge central issues in a controversy (such as evolution)? How can such problems be addressed in a way that is ethically sensitive and intellectually responsible? Drawing in part on pragmatic philosopher John Dewey, our solution is politically proactive, philosophically pragmatic, and grounded in research. Central to our proposal is (1) steps toward creating a philosophical “total attitude” that is democratic, imaginative, and hypothetical; (2) a deeper understanding of how scientific theories can be pragmatically true; and (3) an assessment of differing pedagogical approaches for teaching evolution in the classroom.

  9. A Critique of "Controversial Medical Treatments of Learning Disabilities"

    ERIC Educational Resources Information Center

    Feingold, Benjamin F.

    1977-01-01

    The author replies to the article titled "Controversial Medical Treatments of Learning Disabilities" (R. Sieben), and discusses research on the relationship between food additives and hyperactivity, and dietary treatments for learning disabled children. (IM)

  10. Superluminal Neutrinos: The Good Kind of Science Controversy

    NASA Astrophysics Data System (ADS)

    Lucibella, Michael

    2012-03-01

    After OPERA released results indicating neutrinos were traveling faster than the speed of light, a number of vocal of scientists said that they shouldn't have prematurely engaged in ``science by press release.'' However, controversial claims like this, if handled right, can actually be a boon to science. Getting the public interested in cutting edge physics is notoriously difficult, but the public is always interested in hearing about a controversy. The press conference and following debate becomes a great teaching moment that offers the public a unique opportunity to get an inside and have an in-depth look at how science works. Scientists willing to publicly engage in this kind of civil controversy are important because when other scientific controversies arise, ones with major public policy implications, the public starts out with a better understanding of how science works, and scientists have better practice managing questions from the public.