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1

Infrared analysis of the effect of composition of n-butyltriethoxysilane and gamma-aminopropyltriethoxysilane blends on tertiary amine-catalyzed anhydride-cured epoxy mixtures. Technical report  

Microsoft Academic Search

The enhancement in mechanical properties observed for silane-treated glass-reinforced epoxy materials is highly dependent on the structure of the coupling agent at the interphase. The effect of varying composition of nonhydrolyzed silane coupling agent blends of gamma aminopropyltriethoxysilane (APS) and butyltriethoxysilane (BTS) on the cure of benzyldimethylamine (BDMA)-catalyzed, nadic methyl anhydride (NMA)-cured diglycidyl ether of bisphenol-A epoxy (BDGE) was studied

S. L. Tidrick; H. Ishida; J. L. Koenig

1991-01-01

2

Multifunctional nanoparticles as coupled contrast agents  

PubMed Central

Engineering compact imaging probes with highly integrated modalities is a key focus in bionanotechnology and will have profound impact on molecular diagnostics, imaging, and therapeutics. However, combining multiple components on a nanometer scale to create new imaging modalities unavailable from individual components has proven challenging. Here, we demonstrate iron oxide and gold coupled core-shell nanoparticles with well defined structural characteristics (e.g., size, shell thickness, and core-shell separation) and physical properties (e.g., electronic, magnetic, optical, thermal, and acoustic). The resulting multifunctional nanoprobes not only offer contrast for electron microscopy, magnetic resonance imaging, and scattering-based imaging, but more importantly, enable a new imaging mode, magnetomotive photoacoustic (mmPA) imaging, with remarkable contrast enhancement compared to PA images using conventional nanoparticle contrast agents. PMID:20975706

Jin, Yongdong; Jia, Congxian; Huang, Sheng-Wen; O'Donnell, Matthew; Gao, Xiaohu

2011-01-01

3

One-bottle silane coupling agent containing 4-META.  

PubMed

The effectiveness of commercial and experimental silane coupling agents was evaluated by measuring their shear bond strengths to a ceramic disk. Experimental one-bottle silane coupling agents were prepared using 3-MPTS, 4-META, and resin monomers. The surfaces of two ceramic disks (IPS e-max, Ivoclar Vivadent AG, Schaan, Lichtenstein) were treated by a silane coupling agent to bond them to each other; this bonding was mediated by a commercial flowable resin composite (Clearfil Majesty LV, Kuraray, Tokyo, Japan). A commercial silane coupling agent (Clearfil Porcelain Bond Activator, Kuraray, Tokyo, Japan) modified by adding 4-META exhibited a significantly higher bond strength than the unmodified commercial one-bottle silane coupling agent. Among the tested materials, two experimental one-bottle silane coupling agents composed of 5% 4-META, 45% 3-MPTS, and 50% resin monomers exhibited statistically highest bond strengths. PMID:23719001

Kitahara, Nobuya; Itoh, Kazuo; Kusunoki, Mizuho; Oikawa, Misa; Miyazaki, Takashi

2013-01-01

4

Applications of azidosilane coupling agents in reinforced thermoplastic composites  

Microsoft Academic Search

Treatment of mica, glass microspheres, milled glass fibers and commercial chopped fiberglass with azidosilane coupling agents is shown to significantly improve the mechanical properties of these fillers\\/reinforcements in polyolefins relative to untreated controls. The unique chemistry of the azido groups allows for coupling with a wide variety of thermoplastic polymers. Surface characterization of native and modified fillers has proven to

Kolpak

1986-01-01

5

Modification of Nanosilica Surface by Methyl Methacrylate Silane Coupling Agents  

NASA Astrophysics Data System (ADS)

Composites based on silicas and methyl metacrylate silane coupling agents are advanced materials for sensor technologies. The purpose of the present research is to combine silica-organic compounds with inorganic constituents to tailor the binding properties. It deals with a new method of covering silica nanoparticles by methyl methacrylate silanes in a pseudo-liquid state. The adsorption process and the chemical reactions of metacrylate-containing silanes and the surface of nanosized silica were examined by means of infrared spectroscopy, thermal analysis and transmission electron microscopy (TEM). The study confirmed the total modification of the silica surface with silanes.

Telegeev, Igor; Voronin, Evgenij; Pakhlov, Evgenij

6

Coherent Pattern Prediction in Swarms of Delay-Coupled Agents  

PubMed Central

We consider a general swarm model of self-propelling agents interacting through a pairwise potential in the presence of noise and communication time delay. Previous work has shown that a communication time delay in the swarm induces a pattern bifurcation that depends on the size of the coupling amplitude. We extend these results by completely unfolding the bifurcation structure of the mean field approximation. Our analysis reveals a direct correspondence between the different dynamical behaviors found in different regions of the coupling-time delay plane with the different classes of simulated coherent swarm patterns. We derive the spatiotemporal scales of the swarm structures, as well as demonstrate how the complicated interplay of coupling strength, time delay, noise intensity, and choice of initial conditions can affect the swarm. In particular, our studies show that for sufficiently large values of the coupling strength and/or the time delay, there is a noise intensity threshold that forces a transition of the swarm from a misaligned state into an aligned state. We show that this alignment transition exhibits hysteresis when the noise intensity is taken to be time dependent. PMID:24255625

Mier-y-Teran-Romero, Luis; Forgoston, Eric; Schwartz, Ira B.

2013-01-01

7

Influence of coupling agent’s self-assembly upon performance of polymer coated FBG pressure sensors  

Microsoft Academic Search

Based on super-molecule self-assembly and entropy-driven self-assembly mechanisms, the coupling agent was evolved into colloid\\u000a spheres with average diameter of 2-2. 3 ?m on the fiber Bragg grating (FBG) with silicon substrate, and the coupling mechanism\\u000a among polymer, coupling agent and FBG was analyzed. The polymer coated FBG pressure sensors was capsulated by uniform coupling\\u000a mode and self-assembly coupling mode

Hong Zhou; Xue-Guang Qiao; Shao-Jun; Hong-Liang Wang; De-Quan Feng

2006-01-01

8

Infrared analysis of the effect of composition of silane blends of amino and alkyl silane blends in tertiary amine-catalyzed anhydride-cured epoxy mixtures. Technical report  

Microsoft Academic Search

The property enhancement caused by silane coupling agents in glass-reinforced epoxy matrices is a function of the structure and composition of the silane. The effect of hydrolyzed and nonhydrolyzed of various compositions of silane coupling agent blends of gamma aminopropyltriethoxysilane (APS) and either butyltriethoxysilane (BTS) or ethyltriethoxysilane (ETS) on the cure of a benzyldimethylamine (BDMA)-catalyzed, nadic methyl anhydride (NMA) cured

S. L. Tidrick; H. Ishida; J. L. Koenig

1991-01-01

9

(29)Si solid state NMR studies of the effect of composition of amine and alkyl silane blends in tertiary amine-catalyzed anhydride-cured epoxy mixtures. Technical report  

Microsoft Academic Search

Silane coupling agent blends of gamma-aminopropyltriethoxysilane (APS) and butyltriethoxysilane (BTS) of varying composition were added to an epoxy matrix made of a benzyldimethylamine (BDMA)-catalyzed, nadic methyl anhydride. NMR was utilized in order to determine the effect of composition of the silane coupling agent blend on the mobility of the various portions of the siloxane network. It was found that hydrolysis

S. L. Tidrick; H. Ishida; J. L. Koenig

1991-01-01

10

Preparation of immobilized proteins covalently coupled through silane coupling agents to inorganic supports.  

PubMed

Enzymes were first immobilized on inorganic supports through silane coupling agents over 25 yr ago. Since that initial report, literally hundreds of laboratories have utilized this methodology for the immobilization of enzymes, antigens, antibodies, receptors, and other high and low mol wt compounds. Today silane coupling is one of the commonly used techniques in the arsenal of the biochemist for the binding of material of all sorts to inorganic surfaces. Inorganic materials come in a variety of shapes, sizes, and characteristics. Today silane coupling is one of the most used coupling methods for the preparation of biosensing devices. Sol-gel entrapped enzymes are also produced by the application of silane technology by the polymerization of the silane to form glass-like materials with entrapped protein. This review will discuss the general preparation and characterization of silane coupled proteins with special emphasis on enzymes and describe in detail the actual methods for the silanization and specific chemical coupling of proteins to the silanized carrier. PMID:8379662

Weetall, H H

1993-06-01

11

Delay-dependent coupling for a multi-agent LTI consensus system with inter-agent delays  

NASA Astrophysics Data System (ADS)

Delay-dependent coupling (DDC) is considered in this paper in a broadly studied linear time-invariant multi-agent consensus system in which agents communicate with each other under homogeneous delays, while attempting to reach consensus. The coupling among the agents is designed here as an explicit parameter of this delay, allowing couplings to autonomously adapt based on the delay value, and in order to guarantee stability and a certain degree of robustness in the network despite the destabilizing effect of delay. Design procedures, analysis of convergence speed of consensus, comprehensive numerical studies for the case of time-varying delay, and limitations are presented.

Qiao, Wei; Sipahi, Rifat

2014-01-01

12

Regulating Air Traffic Flow with Coupled Agents Adrian Agogino  

E-print Network

problems. This paper extends agent-based methods for controlling air traffic flow to more realistic domains an agent control structure that allows agents to control air traffic flow through one of three mechanisms flows while making optimal use of current infrastructure. Controlling air traffic flow is a complex task

Tumer, Kagan

13

Further development of high temperature-resistant graphite fiber coupling agents  

NASA Technical Reports Server (NTRS)

Potential coupling agents for graphite fibers were screened by their effect on the weight losses of Thornel 300, HMS, and HTS fibers at 588K for 200 and 400 hours. Unidirectional laminates were made from HMS and HTS fibers, untreated, and treated with each of the seven coupling agents. The matrix of all laminates was PMR polyimide (PMR-PR). On the basis of the best overall retention of elevated temperature interlaminar shear strength after 200 hours at 588K, composite weight after 200 hours at 588K, and fiber weight after 400 hours at 588K, ventromer T-1 applied from aqueous solution and pyrolyzed PPQ were selected for further evaluation as coupling agents for HTS fiber while ventromer T-2 and pyrolyzed PPQ were selected as coupling agents for HMS fiber. It was shown that pyrolyzed PPQ as a coupling agent improves the oxidative stability of HTS/PMR-PI composites.

Griffin, R. N.

1976-01-01

14

Coupled Human and Natural Systems: A Multi-Agent Based Approach  

E-print Network

; Multi-agent models; Land-use change dynamics; Decision models. 1. INTRODUCTION Few ecosystems are freeCoupled Human and Natural Systems: A Multi-Agent Based Approach Monticino, Ma , Acevedo M human stakeholders are represented using multi-agent models that act on forest landscape models

Monticino, Michael

15

Effect of coupling agent on abrasive wear behaviour of chopped jute fibre-reinforced polypropylene composites  

Microsoft Academic Search

In this paper, studies have been conducted to investigate the abrasive wear behaviour of jute fibre-reinforced polypropylene composites. Effect of addition of maleic anhydride-grafted polypropylene (MA-g-PP)-coupling agent by two different approach, sliding distance and load on abrasive wear performance of jute fibre–PP composites has been determined by using a SUGA abrasion tester. Use of coupling agent gives better wear resistance

Navin Chand; U. K. Dwivedi

2006-01-01

16

Polymer-supported siloxane transfer agents for Pd-catalyzed cross-coupling reactions.  

PubMed

The design, synthesis, and validation of a ring-opening metathesis polymerization (ROMP) polymer supporting siloxane transfer agents have been achieved that permit efficient palladium-catalyzed cross-coupling reactions. The solubility properties of the polymer facilitate not only product purification but also polymer recycling without significant loss of cross-coupling activity. PMID:23901881

Nguyen, Minh H; Smith, Amos B

2013-08-16

17

Polymer-Supported Siloxane Transfer Agents for Pd-Catalyzed Cross-Coupling Reactions  

PubMed Central

The design, synthesis and validation of a ROMP polymer supporting siloxane transfer agents have been achieved that permit efficient palladium-catalyzed cross-coupling reactions. The solubility properties of the polymer not only facilitate product purification, but also recycling without significant loss of cross-coupling activity. PMID:23901881

Nguyen, Minh H.; Smith, Amos B.

2013-01-01

18

Effect of Silane Coupling Agents on Rice Straw Fiber/Polymer Composites  

NASA Astrophysics Data System (ADS)

The effect of coupling agents and electron beam (EB) irradiation dose on the mechanical properties of composites made from rice straw fibers and polymers have been studied. Samples were made by hot pressing of mix composition at 130°C. The pressed samples were subjected to electron beam irradiation dose ranged from 10 to 50 kGy. Increasing the electron beam irradiation dose increased the value of flexural strength, modulus of elasticity and impact strength. It was also observed that, the properties of composites containing ?-aminopropyltrimethoxy silane (A-1100) are lower than those of composites containing N-(2aminoethyl)-3-amino propyltrimethoxy silane (A-700) coupling agents. These are attributed to a hydrogen bonding formation between the amine or protonated amine and the hydroxyl groups of rice straw fibers. The presence of coupling agents in the composites during the EB irradiation process produce a more free radicals which are enough to form a chemical bonding between the rice straw fiber and polymer. The thickness swelling and water absorption values decrease with increasing the EB irradiation dose with presence of coupling agents in the composite.

Ismail, M. R.; Yassene, Ali A. M.; Abd El Bary, Hassan M. H.

2012-06-01

19

Development and Evaluation of Novel Coupling Agents for Kenaf-Fiber-Reinforced Unsaturated Polyester Composites  

NASA Astrophysics Data System (ADS)

Natural fibers are gaining popularity as reinforcement materials for thermoset resins over the last two decades. Natural fibers are inexpensive, abundant, renewable and environmentally friendly. Kenaf fibers are one of the natural fibers that can potentially be used for reinforcing unsaturated polyester (UPE). As a polymer matrix, UPE enjoys a 40% market share of all the thermoset composites. This widespread application is due to many favorable characteristics including low cost, ease of cure at room temperature, ease of molding, a good balance of mechanical, electrical and chemical properties. One of the barriers for the full utilization of the kenaf fiber reinforced UPE composites, however, is the poor interfacial adhesion between the natural fibers and the UPE resins. The good interfacial adhesion between kenaf fibers and UPE matrix is essential for generating the desired properties of kenaf-UPE composites for most of the end applications. Use of a coupling agent is one of the most effective ways of improving the interfacial adhesion. In this study, six novel effective coupling agents were developed and investigated for kenaf-UPE composites: DIH-HEA, MFA, NMA, AESO-DIH, AESO-MDI, and AESO-PMDI. All the coupling agents were able to improve the interfacial adhesion between kanaf and UPE resins. The coupling agents were found to significantly enhance the flexural properties and water resistance of the kenaf-UPE composites. Fourier transform infrared spectroscopy (FTIR) confirmed all the coupling agents were covalently bonded onto kenaf fibers. Scanning electron microscopy (SEM) images of the composites revealed the improved interfacial adhesion between kanaf fibers and UPE resins.

Ren, Xiaofeng

20

Silane coupling agent bearing a photoremovable succinimidyl carbonate for patterning amines on glass and silicon surfaces with controlled surface densities  

Microsoft Academic Search

Patterned immobilization of synthetic and biological ligands on material surfaces with controlled surface densities is important for various bioanalytical and cell biological purposes. This paper describes the synthesis, characterization, and application of a novel silane coupling agent bearing a photoremovable succinimidyl carbonate, which enables the photopatterning of various primary amines on glass and silicon surfaces. The silane coupling agent is

Hidekazu Nakayama; Jun Nakanishi; Takahiro Shimizu; Yutaro Yoshino; Hideo Iwai; Shingo Kaneko; Yasuhiro Horiike; Kazuo Yamaguchi

2010-01-01

21

Effect of silane coupling agents on the mooney scorch time of silica-filled natural rubber compound  

Microsoft Academic Search

Mooney scorch time and cure index of silica-filled natural rubber (Hevea Brasiliensis type) compound with and without the presence of silane coupling agents were studied in the temperature range 110–160°C using a Mooney Shearing Disk Viscometer. Two types of silane coupling agents, viz ?-mercaptopropyltrimethoxysilane (A-189) and bis(triethoxysilylpropyl)tetrasulphide (Si-69) of various loadings were used to study the effect of silane coupling

B. T. Poh; C. C. Ng

1998-01-01

22

Smooth, aggregate-free self-assembled monolayer deposition of silane coupling agents on silicon dioxide.  

PubMed

Silane coupling agents (SCAs) are notorious for aggregating during deposition on oxide substrates, leading to nonuniform surface morphologies. To ameliorate this problem, we describe a vapor-phase deposition technique for silane coupling agents employing a spin-coated perfluoropolyether (PFPE) diffusion barrier that facilitates the formation of smooth, aggregate-free self-assembled monolayers (SAMs). Samples fabricated using PFPE barrier layers yielded SAMs exhibiting similar water contact angles, reduced water contact angle hysteresis, and a 2-fold reduction in rms roughness relative to those without a barrier. X-ray photoelectron spectroscopy confirms that the barrier layer can be completely removed after deposition, leaving behind a smooth monolayer. A basic analysis of the agglomerate separation ability of the barrier layers is discussed to understand the critical parameters involved. Generalized guidelines for selecting barrier materials are presented. PMID:23066941

Diebold, Roger M; Clarke, David R

2012-11-01

23

Magnetostrictive properties of titanate coupling agent treated Terfenol-D composites  

NASA Astrophysics Data System (ADS)

As a kind of composites, the bond strength between the polymer matrix and the Terfenol-D particles affects the performance of magnetostrictive composites. By observing the fracture morphologies, the bond strength of the magnetostrictive composites prepared with untreated Terfenol-D was proved weak. Titanate coupling agent was used for particles to improve the bond strength. Contact angle analysis indicates the work of adhesion of the epoxy resin to the treated Terfenol-D is larger than that to the untreated Terfenol-D. Different magnetostrictive composites with 20%, 35% and 50% particle volume fractions were prepared with treated and untreated Terfenol-D particles. Their static and dynamic magnetostriction was tested without pre-stress at room temperature. The results indicate titanate coupling agent treating increases the magnetostrictive properties of magnetostrictive composites, that is probably because the bond strength improves due to the particle treating.

Dong, Xufeng; Qi, Min; Guan, Xinchun; Li, Jinhai; Ou, Jinping

2012-03-01

24

Studies on Hdpe-Coconut Flour Composites: Effect of Coupling Agents and Surface Modification  

NASA Astrophysics Data System (ADS)

This study investigates the mechanical, thermal and morphological behavior of coconut flour/polyethylene composites, with special interest on the influence of the surface modification of coconut flour and the presence of different coupling agents on the interfacial bonding. The different treatments of the composites with an EAA copolymer, with titanate, with 5 and 18 wt% of NaOH and acetylating, confirm the better tensile behavior of these composites.

Albano, C.; González, J.; Hernández, M.; Ichazo, M. N.; Alvarado, Sinai; Ziegler, Dulce Maria

2008-08-01

25

Agent-based Model for the Coupled Human-Climate System  

NASA Astrophysics Data System (ADS)

Integrated assessment models have been used to predict the outcome of coupled economic growth, resource use, greenhouse gas emissions and climate change, both for scientific and policy purposes. These models generally have employed significant simplifications that suppress nonlinearities and the possibility of multiple equilibria in both their economic (DeCanio, 2005) and climate (Schneider and Kuntz-Duriseti, 2002) components. As one step toward exploring general features of the nonlinear dynamics of the coupled system, we have developed a series of variations on the well studied RICE and DICE models, which employ different forms of agent-based market dynamics and "climate surprises." Markets are introduced through the replacement of the production function of the DICE/RICE models with an agent-based market modeling the interactions of producers, policymakers, and consumer agents. Technological change and population growth are treated endogenously. Climate surprises are representations of positive (for example, ice sheet collapse) or negative (for example, increased aerosols from desertification) feedbacks that are turned on with probability depending on warming. Initial results point toward the possibility of large amplitude instabilities in the coupled human-climate system owing to the mismatch between short outlook market dynamics and long term climate responses. Implications for predictability of future climate will be discussed. Supported by the Andrew W Mellon Foundation and the UC Academic Senate.

Zvoleff, A.; Werner, B.

2006-12-01

26

Surface modification of Fe3O4@SiO2 microsphere by silane coupling agent  

NASA Astrophysics Data System (ADS)

In the present study, Fe3O4@SiO2 core-shell microspheres were prepared via two steps. First, Fe3O4 nanoparticles were synthesized by co-precipitation of Fe+3 and Fe+2 as reaction substrates and NaOH as precipitant. Second, the surface of Fe3O4 was coated with silica by hydrolysis of tetraethylorthosilicate as the silica source. Subsequently, in order to reduce the amount of interaction and the agglomeration of Fe3O4@SiO2 microspheres, the silica shell of these particles was modified by vinyltriethoxysilane as the silane coupling agent. The structural properties of the samples were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy analyses. The results indicated that the average sizes of Fe3O4 and Fe3O4@SiO2 particles were about 50 and 500 nm, respectively. Also, the surface characterization of Fe3O4@SiO2 microspheres showed that the silane coupling agent was covalently coupled with the silica surface.

Ahangaran, Fatemeh; Hassanzadeh, Ali; Nouri, Sirous

2013-04-01

27

Study on the process of surface modification of dehydrated palygorskite based on XD-172 silane coupling agent  

Microsoft Academic Search

Three types of dehydrated palygorskites are prepared, and XD-172 silane coupling agents are used to modify dehydrated palygorskite by the drop height method employed to evaluate the effects of surface modification. The optimal modification process parameters are obtained by analyzing the influences of modification agents quality, modification temperature and modification time on drop height, so that it could provide the

Fei Du; Lin He

2010-01-01

28

Investigating the use of coupling agents to improve the interfacial properties between a resorbable phosphate glass and polylactic acid matrix.  

PubMed

Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role of improving the interface between glass reinforcement and polymer matrix. It was found that, with an optimal amount of coupling agent on the surface of the glass/polymer, interfacial shear strength improved by a factor of 5. Evidence of covalent bonding between agent and glass was found for three of the coupling agents investigated, namely: 3-aminopropyltriethoxysilane; etidronic acid and hexamethylene diisocyanate. These three coupling agents also improved the interfacial shear strength and increased the hydrophobicity of the glass surface. It is expected that this would provide an improvement in the macroscopic properties of full-scale composites fabricated from the same materials which may also help to retain these properties for the desired length of time by retarding the breakdown of the fibre/matrix interface within these composites. PMID:22781920

Hasan, Muhammad Sami; Ahmed, Ifty; Parsons, Andrew J; Rudd, Chris D; Walker, Gavin S; Scotchford, Colin A

2013-09-01

29

Cytocompatibility and Mechanical Properties of Short Phosphate Glass Fibre Reinforced Polylactic Acid (PLA) Composites: Effect of Coupling Agent Mediated Interface  

PubMed Central

In this study three chemical agents Amino-propyl-triethoxy-silane (APS), sorbitol ended PLA oligomer (SPLA) and Hexamethylene diisocyanate (HDI) were identified to be used as coupling agents to react with the phosphate glass fibre (PGF) reinforcement and the polylactic acid (PLA) polymer matrix of the composite. Composites were prepared with short chopped strand fibres (l = 20 mm, ? = 20 µm) in a random arrangement within PLA matrix. Improved, initial composite flexural strength (~20 MPa) was observed for APS treated fibres, which was suggested to be due to enhanced bonding between the fibres and polymer matrix. Both APS and HDI treated fibres were suggested to be covalently linked with the PLA matrix. The hydrophobicity induced by these coupling agents (HDI, APS) helped to resist hydrolysis of the interface and thus retained their mechanical properties for an extended period of time as compared to non-treated control. Approximately 70% of initial strength and 65% of initial modulus was retained by HDI treated fibre composites in contrast to the control, where only ~50% of strength and modulus was retained after 28 days of immersion in PBS at 37 °C. All coupling agent treated and control composites demonstrated good cytocompatibility which was comparable to the tissue culture polystyrene (TCP) control, supporting the use of these materials as coupling agent’s within medical implant devices. PMID:24955744

Hasan, Muhammad Sami; Ahmed, Ifty; Parsons, Andrew; Walker, Gavin; Scotchford, Colin

2012-01-01

30

Improved mechanical properties of HDPE/nano-alumina composite through silane coupling agent  

NASA Astrophysics Data System (ADS)

The effect of silane coupling agent to mechanical properties of HDPE/nano-alumina composite was investigated. Nano-alumina used in this study was produced by using sol-gel method. The shape and size of nano-alumina were determined by using TEM. Prior to the usage of nano alumina as a filler in the polymer matrix, (3-methacryloxypropyl) trimethoxysilane (MPS) was used to functionalize the nanoparticles due to its bifunctional nature: hydrolysable group (-Si(OCH3)3) and unsaturated carbon-carbon double bond. The XRD result shows diffraction spectrum of the synthesized nano-alumina. In order to improve the mechanical properties of the composite, nanoalumina was treated with (3-methacryloxypropyl) trimethoxysilane (MPS). A high tensile strength, is achieved at 4 wt% of MPS.

Akmil, N.; Luqman, C. A.; Ahmad, M.; Zaman, K.

2012-11-01

31

Surface modification of nano-TiN by using silane coupling agent  

NASA Astrophysics Data System (ADS)

Titanium nitride (TiN) nano-particles were subjected to graft modification by silane coupling agent (KH-570) via a direct blending method. The hydroxyl groups on the surface of TiN nano-particles can interact with silanol groups [-Si-OCH3] of KH-570 forming an organic coating layer. The covalent bonds (Ti-O-Si) formation was testified by Fourier transform infrared spectra (FTIR) and X-ray photoelectron spectroscopy (XPS). Through transmission electron micrograph (TEM) observations, it was found that KH-570 could improve the dispersibility of nano-TiN particles in ethyl acetate. Thermo gravimetric analysis (TGA) and contact angle measurements indicated that KH-570 molecules were adsorbed or anchored on the surface of nano-TiN particle and the net efficiency of it was 22.76 %, which facilitated to hinder the aggregation of nano-TiN particles.

Cheng, Guojun; Luo, Jiaqi; Qian, Jiasheng; Miao, Jibin

2014-06-01

32

Effect of fibre and coupling agent contents on water absorption and flexural modulus of wood fibre polyethylene composites  

NASA Astrophysics Data System (ADS)

In two previous studies, wood fiber-reinforced polymer composites (WPC) were prepared via melt processing. In particular, a response surface strategy of a 20 run optimal design for these three factors was adopted. It was found that for these WPC mixing torque, melt viscosity, Young's modulus and tensile stress at break were related to the type of wood used, as well as wood and coupling agent contents. In addition, thermal properties and strain at break were mainly affected by wood and coupling agent contents. Here, a more complete characterization of these WPC under extreme environmental conditions is performed. In particular, the effect of coupling agent content, wood fibre content and wood fibre type on water absorption and flexural modulus are reported under different water immersion time and temperature. The results show that water absorption is influenced by all the parameters studied, while flexural modulus is mainly influenced by wood content and immersion temperature.

Tissandier, C.; Zhang, Y.; Rodrigue, D.

2014-05-01

33

Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry  

Microsoft Academic Search

The following work presents the exploration of three chromatographic separations in combination with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of chemical warfare agent degradation products (CWADPs). The robust ionization of ICP is virtually matrix independent thus enabling the examination of sample matrices generally considered too complicated for analysis by electrospray ionization (ESI) or atmospheric pressure chemical ionization

Kevin M. Kubachka; Douglas D. Richardson; Douglas T. Heitkemper; Joseph A. Caruso

2008-01-01

34

The Use of Organic Coupling Agents to Improve the Durability of Steel/epoxy Joints in the Presence of Moisture.  

NASA Astrophysics Data System (ADS)

Despite the unique combination of properties epoxy resins possess, their versatility for structural bonding of metal substrates has not been fully utilized. The use of epoxy resins (and in general all adhesives) has been limited to non-load bearing or low load bearing applications. One of the primary reasons is the bond sensitivity of these resins to water or to high humidity. Recognizing this limitation, this study was undertaken with the goal of developing organic coupling agents which will chemically bond to the surface of steel via a chelate bond. B-diketone coupling agents were synthesized and tested. The coupling agents were applied from organic solution to the surface of a modified napkin ring torsion joint. The joints were bonded with epoxy resin adhesives and water immersed. The bond durability of the adhesive system was determined by subjecting the joints to a shear load. An ammonium citrate pretreatment was developed for use with the B-diketone agents. Optimization studies of the citrate pretreatment and coupling agent concentration were undertaken. The B-diketone coupling agents significantly improved the bond durability of low temperature cured epoxy systems. Polyfunctional mercaptoester coupling agents were also synthesized and evaluated. The effect of functionality, ring size, citrate pretreatment, and atmosphere on bond durability were examined. The mercaptoesters were found to be far superior to the B-diketones in improving bond durability. Low temperature and high temperature cured resins were examined. XPS analysis of 1018 steel treated with the mercaptoesters indicates the formation of polymeric coupling agent layers, approximately 100 (ANGSTROM) thick, on the steel surface. The results also indicate chelate bonding to the steel surface. A two step strength decay curve is observed for the mercaptoester treated systems, irrespective of the mercaptoester or the curing agent used. Plasticization of the mercaptoester layer at the early stages of strength loss is proposed as an explanation of the linear loss of shear strength of the torsion joints with immersion time. Substrate corrosion is thought to be a controlling factor of strength loss at extended immersion times.

Denicola, Anthony John, Jr.

35

Comparison of cure, mechanical, electric properties of EPDM filled with Sm 2O 3 treated by different coupling agents  

Microsoft Academic Search

Composites based on ethylene–propylene–diene rubber (EPDM) were prepared. EPDM was reinforced with 100phr Sm2O3 treated with coupling agents: stearic acid (SA), isopropyl tri(dioctylphosphate) titanate (NDZ102), bis-[-3-(triethoxysilyl)propyl]tetrasulfide (KH845-4), and N-?-(aminoethyl)-?-aminopropylmethyldimethoxysilane (SG-Si602), respectively. Cure, mechanical and electrical properties of the composites were investigated. It was found that carboxyl in coupling agents could retard EPDM cure while amino groups, PO bonds and S

Jun Su; Shuangjun Chen; Jun Zhang; Zhongzi Xu

2009-01-01

36

Interfacial properties of two-carbon fiber reinforced polycarbonate composites using two-synthesized graft copolymers as coupling agents  

SciTech Connect

Two model coupling agents, water-dispersible (WDGP) and tetrahydrofuran (THF)-soluble graft copolymers (TSGP), were synthesized for carbon fiber/polycarbonate (PC) composites. WDGP contains a long polyacrylamide (PAAm) chain grafted on a PC backbone, whereas TSGP contains a short grafted PAAm Chain. Measurements of the interfacial shear strength (IFSS) and other interfacial properties were evaluated using a fragmentation test for two-fiber composites (TFC) to provide the same loading state. Optimal conditions for the treatment was established as a function of treatment time, temperature, initial concentration, and melting procedure. The amount adsorbed on the carbon fiber was higher for WDGP and TSGP were 54% and 74%, respectively. Mechanisms of energy adsorption for WDGP and intermolecular interaction for TSGP can be considered to contribute differently to IFSS improvement. The improvement in IFSS for both coupling agents may be due to chemical and hydrogen bonding in the interface between functional groups in the carbon fiber and PAAm in the coupling agents and to interdiffusion in the interface between PC in coupling agents and matrix PC.

Park, J.M.

2000-05-15

37

Preparation of a Conducting Flexible Material from Silane Coupling Agent and Hydroxyl Terminated Polybutadiene Rubber by Hydrolysis and Condensation  

Microsoft Academic Search

Synthesis and characterization of a flexible polymer produced from silane coupling agent (SCA) and hydroxyl terminated polybutadiene (HTPB) were performed. Mechanical properties of chemically and electrochemically prepared conducting composites synthesized from this polymer were investigated. Conductivities of the composites were also measured. Polypyrrole enhanced the mechanical properties of the chemically prepared conducting composite. Doping with iodine greatly changed the conductivity

Yunus Karatas; Levent Toppare; Teoman Tinçer

2003-01-01

38

A Fundamental Study Into the Surface Functionalization of Soft Glass Microstructured Optical Fibers via Silane Coupling Agents  

Microsoft Academic Search

A method for the functionalization of surfaces within soft glass microstructured optical fibers has been developed, using self assembled monolayers (SAMs) of silane coupling agents. We demonstrate the use of measurements of the fiber capillary fill rate, as a positive test for a functionalized internal surface. A simple theoretical model is used for comparison with measured fill rates. During this

John E. Debs; Heike Ebendorff-Heidepriem; Jamie S. Quinton; Tanya M. Monro

2009-01-01

39

Socio-Ecohydrologic Agents And Services: Integrating Human And Natural Components To Address Coupled System Resilience  

NASA Astrophysics Data System (ADS)

Riparian corridors in arid regions are highly valued for their relative scarcity, and because healthy riparian systems support high levels of biodiversity, can meet human demand for water and water-related resources and functions. Our team is taking a transdiciplinary social-ecological systems approach to assessing riparian corridor resilience in two watersheds (the San Pedro River in USA and Mexico, and the Rio San Miguel in Mexico) through a project funded by the NSF CNH program ("Strengthening Resilience of Arid Region Riparian Corridors"). Multiple perspectives are integrated in the project, including hydrology, ecology, institutional dynamics, and decision making (at the level of both policy and individual choice), as well as the perspectives of various stakeholder groups and individuals in the watersheds. Here we discuss initial findings that center around linking changes in ecohydrology and livelihoods related to decisions in response to climatic, ecological, and social change. The research team is implementing two approaches to integrate the disparate disciplines participating in the research (and the varied perspectives among the stakeholders in this binational riparian context): (1) ecosystem service assessment, and (2) agent based model simulation. We are developing an ecosystem service perspective that provides a bridge between ecological dynamics in the landscape and varied stakeholder perspectives on the implications of ecohydrology for well-being (economic, cultural, ecological). Services are linked on one hand to the spatial patterns of traits of individuals within species (allowing a more predictive application of ecosystem services as they vary with community change in time), and to stakeholder perspectives (facilitating integration of ecosystem services into our understanding of decision making processes) in a case study in the San Pedro River National Conservation Area. The agent- based model (ABM) approach incorporates the influence of human decision-making on spatially-explicit landscapes in a mechanistic way, taking into account social interaction, adaptation, and decision-making at different levels, allowing individual stakeholders to make decisions based on their unique perceptions of their environment, be it economic, social, or ecological awareness. Initial parameterization of the ABM proceeds from a case study centered in the town of Rayón, Sonora, Mexico, where semi-structured interviews were used to elicit perceptions by water resource users of CNH function, change, and solutions relating to livelihood changes in response to several drivers. In both case studies, we see the potential and limitations for an approach to adaptive management and decision support related to water resources that links ecosystem services and agent-based modeling. Methodologically, synthetic approaches such as these may allow coupling of systems for improved assessment and analysis, while at the same time lack a connection to the perspectives of water users and managers on the ground. There is thus potential for a either a loss of system resilience in the face of external change, or an opportunity to increase system resilience by building off perspectives already in place within these coupled socio-ecohydrologic systems.

Pavao-zuckerman, M.; Pope, A.; Chan, D.; Curl, K.; Gimblett, H. R.; Hough, M.; House-Peters, L.; Lee, R.; Scott, C. A.

2012-12-01

40

End-functional silicone coupling agent modified PEO/P(VDF-HFP)/SiO2 nanocomposite polymer electrolyte DSSC  

NASA Astrophysics Data System (ADS)

The end-functional silicone coupling agent (dodecyl-trimethoxysilane, DTMS for short) was used to modify the PEO/P(VDF-HFP)/SiO2 nanocomposite polymer electrolyte (CPE) and the different amounts of DTMS modification effects were studied. The experiments showed the silicone coupling agent with hydrophobic alkyl chains (-C12H25) chemically engineered on the SiO2 nanoparticles, and formed a Si-O-Si cross-linked network in the new nanocomposite polymer electrolyte. Proper content of DTMS modified CPE exhibited improved ionic conductivity and the connection with the photoanode and counter electrode. However, much higher content of the DTMS modification changed the conformation of the polymer network and reduced the ionic movement. Compared with the performance (3.84%) of the original DSSC, the DSSC with functional silicone coupling agent modified CPE (DTMS:SiO2 = 2:1, mol ratio) exhibited improved Jsc (7.94 mA cm-2), Voc (0.624 V) and optimal efficiency (5.2%) (measured at AM1.5, light intensity of 58.4 mW cm-2). The Voc of the silicone coupling agent modified polymer electrolyte DSSC is obviously improved, which is mainly due to that the hydrophobic alkyl chain end groups formed an insulating layer that retarded the electron recombination at the TiO2 nanoporous photoanode/polymer electrolyte interface. The DTMS:SiO2 = 2:1 modified CPE type DSSC exhibited a performance of 6.42% at a light intensity of 32.1 mW cm-2 and 4.94% at 99.2 mW cm-2.

Zhang, Jing; Yang, Ying; Wu, Sujuan; Xu, Sheng; Zhou, Conghua; Hu, Hao; Chen, Bolei; Xiong, Xiaodong; Sebo, Bobby; Han, Hongwei; Zhao, Xingzhong

2008-06-01

41

Synthesis of New Silane Coupling Agents with a Trimellitic Anhydride Group and Application as Primers for Ceramics and Alloys  

Microsoft Academic Search

With a view to improving the bond strength of resin to dental ceramics and alloys, new silane coupling agents, namely 4-tri- chlorosilylpropyl- and 4-trimethoxysilylpropyl-trimellitic anhydride (4-CSTA and 4-MSTA, respectively), were synthesized. In addition, silane mixtures of 4-CSTA with 3-methacryloyloxypropyltrimethoxysilane (3-MPS) and 4-MSTA with 3-MPS were used as primers for adhesion of poly (methyl methacrylate) to glass, silver-palladium-gold alloy (Ag-Pd alloy),

Shigeaki KURATA; Kozo UMEMOTO

2007-01-01

42

Investigating the Applicability of Antibodies Generated within the Human Protein Atlas as Capture Agents in Immunoenrichment Coupled to Mass Spectrometry.  

PubMed

For identification and characterization of proteins in complex samples, immunoenrichment coupled to mass spectrometry is a good alternative due to the sensitivity of the affinity enrichment and the specificity of mass spectrometry analysis. Antibodies are commonly used affinity agents; however, for high-throughput analysis, antibody availability is usually a bottleneck. Here we present a protocol for immunoenrichment coupled to mass spectrometry in a high-throughput setup, where all steps from bead coupling to mass spectrometry sample preparation are performed in parallel in a 96-well format. Antibodies generated within the Human Protein Atlas project were tested for applicability as capture agents. The antibodies were covalently attached to protein A beads, making it possible to reuse the coupled beads at least three times without destroying the antibody binding efficiency. Target proteins were captured from a U251 MG cell lysate, eluted, digested, and analyzed using mass spectrometry. Of 30 investigated antibodies, around 50% could successfully capture the corresponding native target protein, making the available library of more than 21?000 antibodies a valuable resource for immunoenrichment assays. Due to the diversity of different antibodies regarding affinity and specificity, analyzing antibodies in a high-throughput format is challenging. Even though protocol optimization for individual antibodies can be advantageous for future studies, our method enables a fast screening strategy to determine the usefulness of antibodies in immunoenrichment setups. In addition, we show that the specificity of the antibodies can be investigated by using label-free quantification. PMID:25231543

Boström, Tove; Johansson, Henrik J; Lehtiö, Janne; Uhlén, Mathias; Hober, Sophia

2014-10-01

43

Mechanical and dynamic characteristics of encapsulated microbubbles coupled by magnetic nanoparticles as multifunctional imaging and drug delivery agents.  

PubMed

Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multifunctional agents that can satisfy particular diagnostic/therapeutic requirements has been recognized as rather challenging, because there is a lack of comprehensive understanding of how the integration of magnetic nanoparticles to microbubble encapsulating shells affects their mechanical properties and dynamic performance in ultrasound imaging and drug delivery. Here, a multifunctional imaging contrast and in-situ gene/drug delivery agent was synthesized by coupling super paramagnetic iron oxide nanoparticles (SPIOs) into albumin-shelled microbubbles. Systematical studies were performed to investigate the SPIO-concentration-dependence of microbubble mechanical properties, acoustic scattering response, inertial cavitation activity and ultrasound-facilitated gene transfection effect. These demonstrated that, with the increasing SPIO concentration, the microbubble mean diameter and shell stiffness increased and ultrasound scattering response and inertial cavitation activity could be significantly enhanced. However, an optimized ultrasound-facilitated vascular endothelial growth factor transfection outcome would be achieved by adopting magnetic albumin-shelled microbubbles with an appropriate SPIO concentration of 114.7?µg?ml(-1). The current results would provide helpful guidance for future development of multifunctional agents and further optimization of their diagnostic/therapeutic performance in clinic. PMID:25327566

Guo, Gepu; Lu, Lu; Yin, Leilei; Tu, Juan; Guo, Xiasheng; Wu, Junru; Xu, Di; Zhang, Dong

2014-11-01

44

Mechanical and dynamic characteristics of encapsulated microbubbles coupled by magnetic nanoparticles as multifunctional imaging and drug delivery agents  

NASA Astrophysics Data System (ADS)

Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multifunctional agents that can satisfy particular diagnostic/therapeutic requirements has been recognized as rather challenging, because there is a lack of comprehensive understanding of how the integration of magnetic nanoparticles to microbubble encapsulating shells affects their mechanical properties and dynamic performance in ultrasound imaging and drug delivery. Here, a multifunctional imaging contrast and in-situ gene/drug delivery agent was synthesized by coupling super paramagnetic iron oxide nanoparticles (SPIOs) into albumin-shelled microbubbles. Systematical studies were performed to investigate the SPIO-concentration-dependence of microbubble mechanical properties, acoustic scattering response, inertial cavitation activity and ultrasound-facilitated gene transfection effect. These demonstrated that, with the increasing SPIO concentration, the microbubble mean diameter and shell stiffness increased and ultrasound scattering response and inertial cavitation activity could be significantly enhanced. However, an optimized ultrasound-facilitated vascular endothelial growth factor transfection outcome would be achieved by adopting magnetic albumin-shelled microbubbles with an appropriate SPIO concentration of 114.7?µg?ml?1. The current results would provide helpful guidance for future development of multifunctional agents and further optimization of their diagnostic/therapeutic performance in clinic.

Guo, Gepu; Lu, Lu; Yin, Leilei; Tu, Juan; Guo, Xiasheng; Wu, Junru; Xu, Di; Zhang, Dong

2014-11-01

45

Photocatalytic thin films coupled with polymeric microcapsules for the controlled-release of volatile agents upon solar activation  

NASA Astrophysics Data System (ADS)

This work reportson the application of solar-activated photocatalytic thin films that allow the controlled-release of volatile agents (e.g., insecticides, repellents) from the interior of adsorbedpolymericmicrocapsules. In order to standardize the tests, a quantification of the inherent controlled-release of a particular volatile agent is determined by gas chromatography coupled to mass spectroscopy, so that an application can be offered to a wide range of supports from various industrial sectors, such as in textiles (clothing, curtains, mosquito nets). This technology takes advantage of the established photocatalytic property of titanium dioxide (TiO2) for the use as an active surface/site to promote the controlled-release of a specific vapor (volatile agentfrom within the aforementioned microcapsules.

Oliveira, L. F.; Marques, J.; Coutinho, P. J. G.; Parpot, P.; Tavares, C. J.

2013-06-01

46

Wood Fibre Reinforced Polypropylene Composites: Effect of Fibre Geometry and Coupling Agent on Physico-Mechanical Properties  

NASA Astrophysics Data System (ADS)

Wood fibre reinforced polypropylene composites at fibre content 50% by weight have been prepared and different types of wood fibres (hard wood fibre, soft wood fibre, long wood fibre and wood chips) were treated with coupling agent (MAH-PP) to increase the interfacial adhesion with the matrix to improve the dispersion of the particles and to decrease the water sorption properties of the final composite. The present study investigated the tensile, flexural, charpy impact and impact properties of wood fibre reinforced polypropylene composites as a function of coupling agent and fibre length and structure. From the results it is observed that wood chips-PP composites showed better tensile and flexural properties comparative with the other wood fibre-PP composites with the addition of 5%MAH-PP, which is around 65% and 50% for tensile strength and flexural strength respectively. Hard wood fibre-PP composites showed better impact characteristic values comparative to other wood fibre-PP composites with the addition of 5%MAH-PP and damping index decreased about to 60%. Charpy impact strength also increased up to 60% with the addition of 5%MAH-PP for long wood fibre-PP composites. Water absorption and scanning electron microscopy of the composites are also investigated.

Bledzki, Andrzej K.; Faruk, Omar

2003-11-01

47

Evaluation of coupling agents to manufacture hybrid hardboard made from industrial waste fiberglass and wood fiber  

Microsoft Academic Search

Every day, tons of fibrous material are landfilled that could otherwise be used for structural panel products. In this study, we looked at combining fibers from industrial fiberglass insulation trim waste with commercial hardboard fibers and with recycled cor- rugated container fibers to improve the properties of a structural hardboard-like panel. This study also investigated the effectiveness of two coupling

John F. Hunt; Charles B. Vick

48

Modified coupling agents based on thiourea, immobilized onto silica. Thermodynamics of copper adsorption  

NASA Astrophysics Data System (ADS)

New silylating agents synthesized by incorporating the thiourea molecule into precursor agents containing increasing numbers of basic nitrogen atoms, 3-aminopropyltriethoxysilane, N-[3-(trimethoxysilyl)propyl]-ethylenediamine and N-[3-(trimethoxysilyl)propyl]diethylenetri-amine, through a solvent-free methodology were characterized before being successfully immobilized onto silica gel. The spectroscopic results support the elemental analysis, demonstrating that the thiourea molecule reacted in such a way as to maintain free amino groups. NMR data for carbon and silicon nuclei eflucidated the structural features associated with the incorporated chains and their bonds to the silica skeleton, with formation of covalent silicon-carbon bonds. Thermogravimetric data correlated with the degree of functionalization, which was also obtained from elemental analysis. The available basic nitrogen and sulfur atoms attached to the incorporated pendant chains have the ability to coordinate copper to give 1.10, 0.47 and 1.25 mmol g -1 as maximum adsorption capacities for the samples prepared with the silanes containing one, two and three nitrogen atoms on their structures. The thermodynamic data for copper/basic center interactions at the solid/liquid interface were determined through calorimetric titration, and the set of data demonstrated favorable systems for all three newly synthesized derivatized silicas, as shown by exothermic enthalpic data, which yield negative Gibbs free energies for removal of this cation from aqueous solutions by all the newly synthesized materials.

Oliveira, Fernando J. V. E.; da Silva Filho, Edson C.; Melo, Maurício A., Jr.; Airoldi, Claudio

2009-07-01

49

Effects of reducing agents and oxidants on excitation-contraction coupling in skeletal muscle fibres of rat and toad.  

PubMed Central

1. The mechanically skinned fibre technique was used to examine the role of oxidation-reduction in the control of Ca2+ release and contraction in rat and toad skeletal muscle fibres under physiological conditions of myoplasmic [Mg2+] and [ATP] and sarcoplasmic reticulum (SR) Ca2+ load. 2. None of the reducing agents, dithiothreitol (DTT, 10 mM), glutathione (GSH, 10 mM) or cysteine (1 and 5 mM), had any detectable effect on the peak force, duration or the total number of depolarization-induced responses that could be elicited in skinned fibres from either toad or rat muscle, except for a slight alteration in one case (GSH on the duration of the response in rat fibres) caused by an effect of the agent of the Ca2+ sensitivity of the contractile apparatus. 3. Application of the reactive disulphide, 2,2'-dithiodipyridine (DTDP, 100 microM), a potent oxidizing agent, never induced any measurable force response or noticeable depletion of SR Ca2+ in any fibre under the conditions used. When all Ca2+ uptake was prevented, DTDP treatment of rat fibres was found to cause a 2- to 3-fold increase in the low rate of Ca2+ "leak' from the SR. DTDP treatment also increased the responsiveness of toad muscle fibres to 1 or 2 mM caffeine. These effects could be largely reversed by treatment with DTT. These results indicate that oxidation of the Ca2+ release channel does not cause substantial channel opening under physiological conditions. 4. Depolarization-induced force responses in both rat and toad fibres were rapidly abolished in the presence of DTDP (10 or 100 microM), in a manner favoured by inactivation of the voltage sensors. The relatively impermeant oxidant, 5,5'-dithionitrobenzoic acid (DTNB, 100 microM), had an effect very similar to DTDP if applied intracellularly, but unlike DTDP, had little or no effect if applied extracellularly (at 5 mM) before skinning. Depolarization-induced responses could be restored by treatment with DTT (10 mM). Intracellular application of the sulfhydryl-alkylating agent, N-ethylmaleimide (NEM, 100 microM), had effects very similar to DTDP and DTNB. 5. These results are not consistent with the proposal that excitation-contraction coupling in skeletal muscle primarily involves the oxidative linkage of the voltage sensors to the Ca2+ release channels, but do show that oxidation of an intracellularly accessible site can interfere with the coupling, in a process made more sensitive by voltage sensor inactivation. PMID:8930846

Posterino, G S; Lamb, G D

1996-01-01

50

The influence of coupling agents on mechanical property retention and long-term cytocompatibility of phosphate glass fibre reinforced PLA composites.  

PubMed

Completely resorbable composites are an attractive alternative for metallic bone-fracture fixation devices. However, failure of their interfacial integrity within aqueous environments, which can lead to a rapid loss of overall mechanical properties, has been reported in the literature. In this study coupling agents were investigated for phosphate glass fibre reinforced poly(lactic acid) composites. Three coupling agents with varying wettability were employed to improve initial mechanical properties and their retention in vitro via improvement of the interfacial bond between polymer matrix and fibres. Coupling agents were grafted onto the glass fibres by dip-coating in coupling agent solution at optimised concentrations. Three-aminopropyltriethoxy silane and sorbitol ended PLA oligomer treatments improved the initial flexural properties (27% strength with APS and 17% modulus via SPLA treatment) of the composites and 3-aminopropyltriethoxy silane and hexamethylene diisocyanate (HDI) treatments also decreased the loss of flexural strength and modulus during degradation. HDI treated samples retained 57.2% and 64.7% of their initial strength and modulus, respectively compared to control where only 34% of initial strength and 52% of initial modulus was retained after 28 days of degradation in PBS solution. Initial improvements in flexural properties were associated with improved shear bond strength at the interface due to covalent bonding between the glass fibres and polymer matrix provided by the coupling agents. Delay in mechanical property loss with degradation was suggested to be due to the hydrophobicity at the interface, which could have hindered the interfacial integrity loss and consequently loss of mechanical integrity of the composites. All coupling agent treated and control composites were tested for cytocompatibility using a primary human osteoblast cell line. A comparable response to the control, in terms of cell adhesion, proliferation and differentiation was observed supporting the use of these agents within implantable devices. PMID:23959231

Hasan, M S; Ahmed, I; Parsons, A J; Walker, G S; Scotchford, C A

2013-12-01

51

On the use, characterization and performance of silane coupling agents between organic coatings and metallic or ceramic substrates  

NASA Astrophysics Data System (ADS)

Examples are given of the use of organofunctional silane coupling agents for promoting bonding between organic coatings and metallic or ceramic (i.e. oxide) substrates. The orientation of the silane molecules and the type of bonding with the metal oxide can be determined successfully by Time-of-Flight SIMS. Oriented films of aminosilanes are demonstrated to be unstable in air. A prerinse with an inorganic silicate is introduced as a suitable method for masking the ubiquitous carbonaceous contamination at the metal surface, thus promoting the proper orientation and covalent bonding. Some practical applications are described, such as the pretreatment of Galvalume? surfaces as a replacement of existing chromate treatments in coil coating applications. Electrochemical Impedance Spectroscopy (EIS) is shown to be a powerful tool for studying the performance of the silane treatment under a paint.

van Ooij, W. J.; Zhang, B. C.; Conners, K. D.; Hörnström, S.-E.

1996-01-01

52

A Multiplex PCR-coupled Liquid Bead Array for the Simultaneous Detection of Four Biothreat Agents  

SciTech Connect

We have developed a 10-plexed PCR assay coupled to a 12-plexed liquid bead array to rapidly screen environmental samples for B. anthracis, Y. pestis, F. tularensis, and B. melitensis. Highly validated species -specific primer sets were used to simultaneously amplify multiple diagnostic regions unique to each individual pathogen. Resolution of the mix of amplified products was achieved by PCR product hybridization to corresponding probe sequences, attached to unique sets of fluorescent beads. The hybridized beads were processed through a flow cytometer, which detected presence and quantity of each PCR product. The assay was optimized to allow for maximum sensitivity in a multiplexed format. A high- throughput demonstration was performed where 384 simulated environmental samples were spiked with different amounts of B. thuringensis spores and pathogen DNA. The samples were robotically processed to extract DNA and arrayed for multiplexed PCR-liquid bead detection. The assay correctly identified the presence or absence of each pathogen and collected over 3,000 individual data points within a single 8-hour shift for approximately $1.20 per sample in a 10-plexed assay.

Wilson, W J; Erler, A M; Nasarabadi, S L; Skowronski, E W; McCready, P M

2004-02-04

53

Exfoliated graphite nanoplatelet-filled impact modified polypropylene nanocomposites: influence of particle diameter, filler loading, and coupling agent on the mechanical properties  

NASA Astrophysics Data System (ADS)

Exfoliated graphite nanoplatelets (xGnP)-filled impact-modified polypropylene (IMPP) composites were prepared at 2, 4, 6, and 8 wt % xGnP with and without the addition of a coupling agent and manufactured using melt mixing followed by injection molding. The coupling agent used in this study was polypropylene-graft-maleic anhydride (PP-g-MA). The nanoparticles used were xGnP with three different sizes: xGnP5 has an average thickness of 10 nm, and an average platelet diameter of 5 ?m, whereas xGnP15 and xGnP25 have the same thickness but average diameters are 15 and 25 ?m, respectively. Test results show that nanocomposites with smaller xGnP diameter exhibited better flexural and tensile properties for both neat and compatibilized composites. For composites containing a coupling agent, tensile and flexural modulus and strength increased with the addition of xGnP. In the case of neat composites, both tensile and flexural modulus and strength decreased at higher filler loading levels. Increasing xGnP loading resulted in reduction of elongation at break for both neat and composites containing coupling agent. Explanation of this brittle behavior in a nanoplatelet-filled IMPP is presented using scanning electron microscopy and transmission electron microscopy.

Duguay, Alex J.; Nader, Jacques W.; Kiziltas, Alper; Gardner, Douglas J.; Dagher, Habib J.

2013-03-01

54

Exfoliated graphite nanoplatelet-filled impact modified polypropylene nanocomposites: influence of particle diameter, filler loading, and coupling agent on the mechanical properties  

NASA Astrophysics Data System (ADS)

Exfoliated graphite nanoplatelets (xGnP)-filled impact-modified polypropylene (IMPP) composites were prepared at 2, 4, 6, and 8 wt % xGnP with and without the addition of a coupling agent and manufactured using melt mixing followed by injection molding. The coupling agent used in this study was polypropylene-graft-maleic anhydride (PP-g-MA). The nanoparticles used were xGnP with three different sizes: xGnP5 has an average thickness of 10 nm, and an average platelet diameter of 5 ?m, whereas xGnP15 and xGnP25 have the same thickness but average diameters are 15 and 25 ?m, respectively. Test results show that nanocomposites with smaller xGnP diameter exhibited better flexural and tensile properties for both neat and compatibilized composites. For composites containing a coupling agent, tensile and flexural modulus and strength increased with the addition of xGnP. In the case of neat composites, both tensile and flexural modulus and strength decreased at higher filler loading levels. Increasing xGnP loading resulted in reduction of elongation at break for both neat and composites containing coupling agent. Explanation of this brittle behavior in a nanoplatelet-filled IMPP is presented using scanning electron microscopy and transmission electron microscopy.

Duguay, Alex J.; Nader, Jacques W.; Kiziltas, Alper; Gardner, Douglas J.; Dagher, Habib J.

2014-03-01

55

Influence of Electron Beam Irradiation and Coupling Agents on the Thermal Stability of Sugar Cane Bagasse Fiber-Thermoplastics Scrape Composite  

Microsoft Academic Search

The influence of blending of sugar cane bagasse with thermoplastics scrape as well as incorporation of some coupling agents has been conducted using thermogravimetric analysis (TGA). In addition, the effect of electron beam preirradiation of low density polyethylene on the properties of the bagasse-LDPE composite was also studied. Simulation of TGA data reveals that the presence of bagasse fiber accelerates

H. A. Youssef; M. A. M. Ali; M. R. Ismail; A. H. Zahran

2007-01-01

56

Effect of a silane coupling agent on the optical and the mechanical characteristics of nanodiamond/acrylic resin composites  

NASA Astrophysics Data System (ADS)

Nanodiamond (ND) is a good candidate for a filler material to fabricate transparent films. This study explores a characterization of the optical and the mechanical properties of ND dispersed polymer films. An attrition milling method was adapted to break ND aggregates, and a silane coupling agent (3-methacryloxypropyltrimethoxysilane) was used to modify the ND surfaces and stabilize the dispersion. Dipentaerylthritol hexaacrylate and pentaerythritol tetraacrylate were used in the polymer matrix, and up to 3 wt.% of ND was added to improve the mechanical properties. Fabricated composites were analyzed and tested using UV-visible spectroscopy for the optical properties and a Micro-Vickers hardness tester and ball-on-disktype friction tester for the mechanical properties. Results show that the transmittance of the ND-added composite increased with decreasing aggregate size. Through the addition of small amounts of NDs, the mechanical properties were greatly improved, the material became 3.5 times as hard, and the wear rate were greatly decreased. Possible mechanisms responsible for the enhancement of the mechanical and the optical properties are discussed.

Jeong, Min-Gun; Chun, Yoon-Soo; Lim, Dae-Soon; Kim, Jung Youl

2014-10-01

57

A high efficient method for introducing reactive amines onto carbon fiber surfaces using hexachlorocyclophosphazene as a new coupling agent  

NASA Astrophysics Data System (ADS)

To improve the interfacial properties of carbon fiber (CF) reinforced composites, an innovative and simple functionalized strategy has been proposed by grafting 4,4?-oxydianiline (ODA) onto carbon fiber surface using hexachlorocyclophosphazene (HCCP) as a novel coupling agent at mild reaction conditions. The chemical composition of the CF surface was confirmed by X-ray photoelectron spectra (XPS). The surface topography and surface energy of CF were examined by atomic force microscope (AFM) and dynamic contact angle tests (DCA), respectively. The interfacial shear strength (IFSS) of CF reinforced composites was studied by microbond test. The tensile strength of CF was measured by single filament tensile test. After functionalization treatment, the grafted amine groups on the fiber surface enhanced the surface wettability of modified CF and formed strong chemical bonding between fiber and matrix, improving the interfacial adhesion strength of composites. The interfacial shear strength of modified CF reinforced composites increased by 71.2% compared with that of desized CF. The interfacial enhancement mechanism was also discussed in detail. Moreover, the modified CF almost kept the original mechanical properties after functionalization.

Xu, Haibing; Zhang, Xiaoqing; Liu, Dong; Chun, Yan; Fan, Xinyu

2014-11-01

58

Synthesis of new silane coupling agents with a trimellitic anhydride group and application as primers for ceramics and alloys.  

PubMed

With a view to improving the bond strength of resin to dental ceramics and alloys, new silane coupling agents, namely 4-trichlorosilylpropyl- and 4-trimethoxysilylpropyl-trimellitic anhydride (4-CSTA and 4-MSTA, respectively), were synthesized. In addition, silane mixtures of 4-CSTA with 3-methacryloyloxypropyltrimethoxysilane (3-MPS) and 4-MSTA with 3-MPS were used as primers for adhesion of poly (methyl methacrylate) to glass, silver-palladium-gold alloy (Ag-Pd alloy), and cobalt-chromium alloy (Co-Cr alloy). The tensile bond strengths of resin to glass using 4-CSTA+3-MPS and 4-MSTA+3-MPS were 28.5 +/- 5.3 and 23.9 +/- 8.1 MPa respectively. With the metal alloys, the strengths were 14.8 +/- 5.3 MPa for Ag-Pd alloy and 24.7 +/- 7.2 MPa for Co-Cr alloy. In the light of these results obtained, it seemed that the mixture of 4-MSTA and 3-MPS was an effective primer for both metals and ceramics. PMID:18203484

Kurata, Shigeaki; Umemoto, Kozo

2007-11-01

59

Hyperfine coupling constants on inner-sphere water molecules of Gd(III)-based MRI contrast agents.  

PubMed

Herein we present a theoretical investigation of the hyperfine coupling constants (HFCCs) on the inner-sphere water molecules of [Gd(H(2)O)(8)](3+) and different Gd(III)-based magnetic resonance imaging contrast agents such as [Gd(DOTA)(H(2)O)](-), [Gd(DTPA)(H(2)O)](2-), [Gd(DTPA-BMA)(H(2)O)] and [Gd(HP-DO3A)(H(2)O)]. DFT calculations performed on the [Gd(H(2)O)(8)](3+) model system show that both hybrid-GGA functionals (BH&HLYP, B3PW91 and PBE1PBE) and the hybrid meta-GGA functional TPSSh provide (17)O HFCCs in close agreement with the experimental data. The use of all-electron relativistic approaches based on the DKH2 approximation and the use of relativistic effective core potentials (RECP) provide results of essentially the same quality. The accurate calculation of HFCCs on the [Gd(DOTA)(H(2)O)](-), [Gd(DTPA)(H(2)O)](2-), [Gd(DTPA-BMA)(H(2)O)] and [Gd(HP-DO3A)(H(2)O)] complexes requires an adequate description of solvent effects. This was achieved by using a mixed cluster/continuum approach that includes explicitly two second-sphere water molecules. The calculated isotropic (17)O HFCCs (A(iso)) fall within the range 0.40-0.56 MHz, and show deviations from the corresponding experimental values typically lower than 0.05 MHz. The A(iso) values are significantly affected by the distance between the oxygen atom of the coordinated water molecule and the Gd(III) ion, as well as by the orientation of the water molecule plane with respect to the Gd-O vector. (1)H HFCCs of coordinated water molecules and (17)O HFCCs of second-sphere water molecules take values close to zero. PMID:22927182

Esteban-Gómez, David; de Blas, Andrés; Rodríguez-Blas, Teresa; Helm, Lothar; Platas-Iglesias, Carlos

2012-11-12

60

Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent  

PubMed Central

Bioresorbable composite made from degradable polymers, e.g., polylactide (PLA), and bioactive calcium phosphates, e.g., hydroxyapatite (HA), are clinically desirable for bone fixation, repair and tissue engineering because they do not need to be removed by surgery after the bone heals. However, preparation of PLA/HA composite from non-modified HA usually results in mechanical strength reductions due to a weak interface between PLA and HA. In this study, a calcium-phosphate/phosphonate hybrid shell was developed to introduce a greater amount of reactive hydroxyl groups onto the HA particles. Then, PLA was successfully grafted on HA by surface-initiated polymerization through the non-ionic surface hydroxyl groups. Thermogravimetric analysis indiated that the amount of grafted PLA on HA can be up to 7 %, which is about 50 % greater than that from the literature. PLA grafted HA shows significantly different pH dependent ?-potential and particle size profiles from those of uncoated HA. By combining the phosphonic acid coupling agent and surface initiated polymerization, PLA could directly link to HA through covalent bond so that the interfacial interaction in the PLA/HA composite can be significantly improved. The diametral tensile strength of PLA/HA composite prepared from PLA-grafted HA was found to be over twice that of the composite prepared from the non-modified HA. Moreover, the tensile strength of the improved composite was 23 % higher than that of PLA alone. By varying additional variables, this approach has the potential to produce bioresorbable composites with improved mechanical properties that are in the range of natural bones, and can have wide applications for bone fixation and repair in load-bearing areas. PMID:22399838

Wang, Tongxin; Chow, Laurence C.; Frukhtbeyn, Stanislav A.; Ting, Andy Hai; Dong, Quanxiao; Yang, Mingshu; Mitchell, James W.

2012-01-01

61

Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry  

Microsoft Academic Search

In this paper, an analytical method for the determination of six iodinated X-ray contrast agents (amidotrizoic acid, iohexol, iomeprol, iopamidol, iopromide, and ioxitalamic acid), iodide, and iodate in water samples is presented. The method is based on a separation of the analytes by ion chromatography (IC) and a subsequent detection by inductively-coupled plasma mass spectrometry (ICP-MS). The method was optimised

Frank Sacher; Brigitte Raue; Heinz-Jürgen Brauch

2005-01-01

62

Modification of activated carbon with different agents and catalytic performance of products obtained in the process of ethylbenzene dehydrogenation coupled with nitrobenzene hydrogenation  

Microsoft Academic Search

Coupling of oxidative dehydrogenation of ethylbenzene with nitrobenzene hydrogenation (ODE-N), over activated carbons catalysts, has been investigated. Activated carbon was prepared from cherry stones and modified with different chemical agents in the liquid phase (HNO3, CH3COOOH, H2O2, (NH4)2S2O8) or gas phase (air, hydrogen, ammonia) or was subjected to thermal treatment to obtain materials with different surface properties. The initial carbon

Anna Malaika; Mieczys?aw Koz?owski

2011-01-01

63

Effect of silane coupling agent on vulcanization, network structure, polymer-filler interaction, physical properties and failure mode of mica-filled styrene-butadiene rubber  

Microsoft Academic Search

Physical properties of composites from mica and styrene-butadiene rubber (SBR) have been studied with special reference to the effect of silane coupling agent (A-174) in the compound. Tensile and tear properties increase with the addition of mica. The increase of tensile properties in more pronounced in the case of silane-treated mica. Silane treatment also raises the volume fraction of rubber

S. Debnath; S. K. De; D. Khastgir

1987-01-01

64

Sensitive quantification of gadolinium-based magnetic resonance imaging contrast agents in surface waters using hydrophilic interaction liquid chromatography and inductively coupled plasma sector field mass spectrometry.  

PubMed

The application of gadolinium(Gd)-based contrast agents to support medical examinations by magnetic resonance imaging (MRI) results in a large input of Gd into the environment. The long-term effects of the anthropogenic Gd anomaly, especially on aqueous ecosystems, are mostly unknown. The identification and quantification of Gd-based contrast agents in the aquatic environment requires the use of powerful methods of speciation analysis. Therefore, a method employing the hyphenation of hydrophilic interaction liquid chromatography (HILIC) and inductively coupled plasma sector field mass spectrometry (ICP-SFMS) with sample introduction as dry aerosol generated by desolvation was developed. The desolvation resulted in improved limits of detection for the predominantly used contrast agents well below 0.10 nmol/L. This method was subsequently used for the analysis of Gd species in surface waters. Samples from a nature reserve in the city of Münster (Germany), into which the effluent from the city's main wastewater treatment plant enters the environment, were examined. The contrast agents Gd-DTPA, Gd-DOTA and Gd-BT-DO3A were identified and quantified in constant ratios in those samples. The concentrations were found in a range from 0.59 nmol/L for Gd-DOTA up to 3.55 nmol/L for Gd-BT-DO3A. As a result of mass balancing, the contrast agent concentration was found to account for 74-89% of total Gd concentrations, possibly indicating the presence of further Gd species. Nevertheless, there was no direct indication of species transformation by transmetallation reactions resulting in such Gd species. The determination of REE patterns by means of ICP-MS confirmed the results of speciation analysis showing significant Gd anomalies. PMID:23958698

Birka, Marvin; Wehe, Christoph A; Telgmann, Lena; Sperling, Michael; Karst, Uwe

2013-09-20

65

Novel one-pot fabrication of lab-on-a-bubble@Ag substrate without coupling-agent for surface enhanced Raman scattering.  

PubMed

Through in-situ reduction of silver nitrate without using any coupling-agent, a substrate for surface-enhanced Raman scattering (SERS) was prepared by coating silver on hollow buoyant silica microspheres as a lab on a bubble (LoB). The silver coated LoBs (LoBs@Ag) floated on surface of a solution could provide a very convenient platform for the detection of target molecules in the solution. The LoBs@Ag substrate not only immobilized well-distributed Ag nanoparticles on the surface LoBs, but excluded the interference of coupling agents. This yielded high-resolution SERS spectra with excellent reproducibility. The adsorption of crystal violet (CV) on the LoBs@Ag substrate was investigated by means of SERS combined with density functional theory (DFT) calculations. The LoBs@Ag substrate exhibited a remarkable Raman enhancement effect for CV with an enhancement factor of 6.9 × 10(8) and wide adaptability from dye, pesticide to bio-molecules. On the basis of this substrate, a simple and sensitive SERS method was proposed for the determination of trace organic pollutants or bio-molecules. PMID:24487575

Jiang, Jizhou; Ou-Yang, Lei; Zhu, Lihua; Zou, Jing; Tang, Heqing

2014-01-01

66

Novel One-pot Fabrication of Lab-on-a-Bubble@Ag Substrate without Coupling-agent for Surface Enhanced Raman Scattering  

NASA Astrophysics Data System (ADS)

Through in-situ reduction of silver nitrate without using any coupling-agent, a substrate for surface-enhanced Raman scattering (SERS) was prepared by coating silver on hollow buoyant silica microspheres as a lab on a bubble (LoB). The silver coated LoBs (LoBs@Ag) floated on surface of a solution could provide a very convenient platform for the detection of target molecules in the solution. The LoBs@Ag substrate not only immobilized well-distributed Ag nanoparticles on the surface LoBs, but excluded the interference of coupling agents. This yielded high-resolution SERS spectra with excellent reproducibility. The adsorption of crystal violet (CV) on the LoBs@Ag substrate was investigated by means of SERS combined with density functional theory (DFT) calculations. The LoBs@Ag substrate exhibited a remarkable Raman enhancement effect for CV with an enhancement factor of 6.9 × 108 and wide adaptability from dye, pesticide to bio-molecules. On the basis of this substrate, a simple and sensitive SERS method was proposed for the determination of trace organic pollutants or bio-molecules.

Jiang, Jizhou; Ou-Yang, Lei; Zhu, Lihua; Zou, Jing; Tang, Heqing

2014-02-01

67

An IETS study of a silane coupling agent; the interaction of 3-(trimethoxysilyl)propanethiol with aluminium oxide and silver surfaces  

NASA Astrophysics Data System (ADS)

The inelastic electron tunnelling spectrum of a silane coupling agent, 3-(trimethoxysilyl)propanethiol, is presented. Approximately monolayer quantities of this silane are present on the barrier oxide of an aluminium-aluminium oxide-metal tunnelling junction, in which the counter electrode is either lead or silver. It is deduced from the IETS spectra that the alkoxy groups of this silane condense with the surface hydroxyl groups. No interaction with the lead is observed but the silver layer clearly reacts with the thiol group of the silane molecule, since the thiol stretching vibration is absent in the spectra, and probably forms the corresponding silver thiolate. The influence of this reaction on the conformation of the bound silane is discussed.

Van Velzen, Peter N. T.

1984-05-01

68

Portable solid phase micro-extraction coupled with ion mobility spectrometry system for on-site analysis of chemical warfare agents and simulants in water samples.  

PubMed

On-site analysis is an efficient approach to facilitate analysis at the location of the system under investigation as it can result in more accurate, more precise and quickly available analytical data. In our work, a novel self-made thermal desorption based interface was fabricated to couple solid-phase microextraction with ion mobility spectrometry for on-site water analysis. The portable interface can be connected with the front-end of an ion mobility spectrometer directly without other modifications. The analytical performance was evaluated via the extraction of chemical warfare agents and simulants in water samples. Several parameters including ionic strength and extraction time have been investigated in detail. The application of the developed method afforded satisfactory recoveries ranging from 72.9% to 114.4% when applied to the analysis of real water samples. PMID:25384006

Yang, Liu; Han, Qiang; Cao, Shuya; Yang, Jie; Yang, Junchao; Ding, Mingyu

2014-01-01

69

Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis  

PubMed Central

Background Hematopoiesis is a complex process involving different cell types and feedback mechanisms mediated by cytokines. This complexity stimulated various models with different scopes and applications. A combination of complementary models promises to provide their mutual confirmation and to explain a broader range of scenarios. Here we propose a combination of an ordinary differential equation (ODE) model of human granulopoiesis and an agent-based model (ABM) of hematopoietic stem cell (HSC) organization. The first describes the dynamics of bone marrow cell stages and circulating cells under various perturbations such as G-CSF treatment or chemotherapy. In contrast to the ODE model describing cell numbers, our ABM focuses on the organization of individual cells in the stem population. Results We combined the two models by replacing the HSC compartment of the ODE model by a difference equation formulation of the ABM. In this hybrid model, regulatory mechanisms and parameters of the original models were kept unchanged except for a few specific improvements: (i) Effect of chemotherapy was restricted to proliferating HSC and (ii) HSC regulation in the ODE model was replaced by the intrinsic regulation of the ABM. Model simulations of bleeding, chronic irradiation and stem cell transplantation revealed that the dynamics of hybrid and ODE model differ markedly in scenarios with stem cell damage. Despite these differences in response to stem cell damage, both models explain clinical data of leukocyte dynamics under four chemotherapy regimens. Conclusions ABM and ODE model proved to be compatible and were combined without altering the structure of both models. The new hybrid model introduces model improvements by considering the proliferative state of stem cells and enabling a cell cycle-dependent effect of chemotherapy. We demonstrated that it is able to explain and predict granulopoietic dynamics for a large variety of scenarios such as irradiation, bone marrow transplantation, chemotherapy and growth factor applications. Therefore, it promises to serve as a valuable tool for studies in a broader range of clinical applications, in particular where stem cell activation and proliferation are involved. PMID:24180697

2013-01-01

70

Adsorption of benzoic acid on pure and cupric ion-modified hydroxyapatite: implications for design of a coupling agent to dental polymer composites.  

PubMed

The adsorption isotherms of benzoic acid on synthetic hydroxyapatite (containing about 1.5 monolayers of physisorbed water) were studied from ethanol, dimethylsulfoxide, p-dioxane, methylene chloride, and benzene to discern the role of solvent in the process. The adsorption is reversible from the first three solvents and follows the Langmuir plots. It is irreversible from the last two, and a constant amount of absorbent is removed from solutions above a certain concentration. The isotherms of potassium benzoate on the apatite from ethanol and dimethyl sulfoxide were reversible. The isotherms of the acid on cupric ion-modified apatite surfaces from ethanol and benzene were identical with those obtained on the pure hydroxyapatite. This may demonstrate that any "surface chelation" with the cation may not be a significant factor for adsorption to occur. The adsorptive behavior seems to depend upon the interplay of hydrogen-bonding among the solute, the solvent, and the hydrated apatite surface. The capability of a solvent to hydrogen-bond may determine whether adsorption from it will be reversible or irreversible. Based upon its compatibility with a solvent, the benzene ring is upright or lies flat on the surface. The adsorbed molecules rotate about the center of the carboxylate groups which are hydrogen-bonded to the surface. These factors should be considered in designing or selecting a suitable surface-active moiety for a coupling agent between tooth mineral and a restorative resin. PMID:3009580

Misra, D N

1986-05-01

71

Grafting of a functionalized side-chain liquid crystal polymer on carbon fiber surfaces: Novel coupling agents for fiber/polymer matrix composites  

SciTech Connect

The authors studied covalent grafting to functionalized carbon fibers of a specially designed liquid crystalline monomer and its corresponding side-chain liquid crystalline polymer containing pendant chemical functions on their mesogenic groups. From a materials point of view these liquid crystalline compounds could act as coupling agents at fiber/polymer matrix interfaces, offering a mechanism to control composite properties not only through bonding but also through their [open quotes]spontaneous[close quotes] molecular orientation in interfacial regions. The grafting methodology for both monomer and polymer to fiber surfaces involved esterification through carbodiimide chemistry in solution. Carboxylic acid groups found on functionalized carbon fiber surfaces were esterified to phenolic functions in the side chains of the experimental polymer. Following grafting procedures the fibers were analyzed by scanning electron microscopy (SEM) and by contact angle measurements. SEM micrographs of fibers grafted with polymer revealed the presence of strongly attached polymeric material on the graphitic surface after rigorous extraction with polymer solvent. Contact angle measurements and polar/dispersive free energy analysis indicated also a smaller polar component of the surface free energy of fibers possibly due to the hydrophobic polymer backbone grafted on the carbon surfaces. On the basis of results, it is concluded that the esterification reaction grafted the polyphenolic liquid-crystal polymer on graphite fiber surfaces. 24 refs., 8 figs., 4 tabs.

Le Bonheur, V.; Stupp, S.I. (Univ. of Illinois, Urbana, IL (United States))

1993-09-01

72

Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications  

PubMed Central

Summary (1H-Benzo[d][1,2,3]triazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), 1H-benzo[d][1,2,3]triazol-1-yl 4-methylbenzenesulfonate (Bt-OTs), and 3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl 4-methylbenzenesulfonate (At-OTs) are classically utilized in peptide synthesis for amide-bond formation. However, a previously undescribed reaction of these compounds with alcohols in the presence of a base, leads to 1-alkoxy-1H-benzo- (Bt-OR) and 7-azabenzotriazoles (At-OR). Although BOP undergoes reactions with alcohols to furnish 1-alkoxy-1H-benzotriazoles, Bt-OTs proved to be superior. Both, primary and secondary alcohols undergo reaction under generally mild reaction conditions. Correspondingly, 1-alkoxy-1H-7-azabenzotriazoles were synthesized from At-OTs. Mechanistically, there are three pathways by which these peptide-coupling agents can react with alcohols. From 31P{1H}, [18O]-labeling, and other chemical experiments, phosphonium and tosylate derivatives of alcohols seem to be intermediates. These then react with BtO? and AtO? produced in situ. In order to demonstrate broader utility, this novel reaction has been used to prepare a series of acyclic nucleoside-like compounds. Because BtO? is a nucleofuge, several Bt-OCH2Ar substrates have been evaluated in nucleophilic substitution reactions. Finally, the possible formation of Pd ?–allyl complexes by departure of BtO? has been queried. Thus, alpha-allylation of three cyclic ketones was evaluated with 1-(cinnamyloxy)-1H-benzo[d][1,2,3]triazole, via in situ formation of pyrrolidine enamines and Pd catalysis. PMID:25246951

Singh, Manish K; Kumar, Mukesh; Chamala, Raghu Ram; Yedulla, Vijayender R; Wagner, Domenick; Leung, Evan; Yang, Lijia; Matin, Asha; Ahmad, Sadia

2014-01-01

73

The Effects of Short Glass Fibre (SGF) Loading and a Silane Coupling Agent on Properties of Polypropylene\\/Waste Tyre Dust\\/Short Glass Fibre (PP\\/WTD\\/SGF) Composites  

Microsoft Academic Search

The properties of polypropylene\\/waste tyre dust\\/short glass fibre (PP\\/WTD\\/SGF) composites at 0 to 20 php SGF loading, with and without a silane coupling agent, ?-aminopropyltrimethoxysilane (?-APS) were studied. The results reveal that the equilibrium torque and Young's modulus increased while tensile strength and elongation at break decreased as SGF loading increased. SEM micrographs show poor adhesion of SGF-PP\\/WTD while FTIR analysis

Z. Zainal; H. Ismail

2011-01-01

74

Sensitive Agent: Sensitive Agent  

E-print Network

social interaction must be simulated. Conventional agents already have rich communication skills including nonverbal communication; however, lack the sensitivity that is necessary for social interaction-78. [13] MIT, Affective Computing, http://affect.media.mit.edu/AC_affect.html [14] Helmut Prendinger

Nakanishi, Hideyuki

75

Efficacy of reducing agent and surfactant contacting pattern on the performance characteristics of nickel electroless plating baths coupled with and without ultrasound.  

PubMed

This article addresses furthering the role of sonication for the optimal fabrication of nickel ceramic composite membranes using electroless plating. Deliberating upon process modifications for surfactant induced electroless plating (SIEP) and combined surfactant and sonication induced electroless plating (SSOEP), this article highlights a novel method of contacting of the reducing agent and surfactant to the conventional electroless nickel plating baths. Rigorous experimental investigations indicated that the combination of ultrasound (in degas mode), surfactant and reducing agent pattern had a profound influence in altering the combinatorial plating characteristics. For comparison purpose, purely surfactant induced nickel ELP baths have also been investigated. These novel insights consolidate newer research horizons for the role of ultrasound to achieve dense metal ceramic composite membranes in a shorter span of total plating time. Surface and physical characterizations were carried out using BET, FTIR, XRD, FESEM and nitrogen permeation experiments. It has been analyzed that the SSOEP baths provided maximum ratio of percent pore densification per unit metal film thickness (PPD?) and hold the key for further fine tuning of the associated degrees of freedom. On the other hand SIEP baths provided lower (PPD?) ratio but higher PPD. For SSOEP baths with dropwise reducing agent and bulk surfactant, the PPD and metal film thickness values were 73.4% and 8.4 ?m which varied to 66.9% and 13.3 ?m for dropwise reducing agent and drop surfactant case. PMID:24480601

Agarwal, Amrita; Pujari, Murali; Uppaluri, Ramgopal; Verma, Anil

2014-07-01

76

Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti-Breast Cancer Agents**  

PubMed Central

?-Hydrogen-containing alkyl Grignard reagents were used in a stereospecific nickel-catalyzed cross-coupling reaction to form sp3–sp3 carbon–carbon bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells. PMID:24478275

Osborne, Charlotte A.; Moore, Curtis E.; Morrissette, Naomi S.; Jarvo, Elizabeth R.

2014-01-01

77

Biological Agents  

MedlinePLUS

... Statistics Training Publications Newsroom Small Business Anti-Retaliation Biological Agents Safety and Health Topics A-Z Index What's New Biological agents include bacteria, viruses, fungi, other microorganisms and ...

78

Surface modification of ZrO2 nanoparticles with styrene coupling agent and its effect on the corrosion behaviour of epoxy coating  

NASA Astrophysics Data System (ADS)

The surface of ZrO2 nanoparticles was modified by styrene coupling grafting method to improve the dispersion and interaction of the nanoparticles with the epoxy coating in which the modified ZrO2 nanoparticles were used as an additive. The grafting performance and microstructure of the nano-ZrO2/epoxy coating were analyzed by Fourier transformation infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The corrosion behavior of the nano-ZrO2/epoxy coating on mild steel was evaluated in neutral 3.5 wt% NaCl solution using electrochemical impedance spectroscopy (EIS). Both the coating capacitance and coating resistance fitted by the equivalent circuit from EIS were used to evaluate the protective performance of the coating towards the mild steel. The results show a superior stability and efficient corrosion protection by the modified ZrO2 nanoparticles. The epoxy coating containing 2 wt% modified ZrO2 nanoparticles exhibited the best corrosion performance among all the coating specimens. This research may provide an insight into the protection of mild steel using modified epoxy coatings.

Zhao, Xia; Liu, Shuan; Wang, Xiutong; Hou, Baorong

2014-09-01

79

Software agents  

Microsoft Academic Search

this paper, we discuss these questions and describe someemerging technologies that provide answers. In the final section, we mention some additionalissues and summarize the key points of the paper. (For more information onagent-based software engineering, see [Genesereth 1989] and [Genesereth 1992]. See also[Shoham 1993] for a description of a variation of agent-based software engineering knownas "agent-oriented programming".)2. Agent Communication Language

Michael R. Genesereth; Steven P. Ketchpel

1994-01-01

80

[Diuretic agent].  

PubMed

This clause explains a diuretic as an antihypertensive agent. A diuretic is a medicine used as a first-line agent also in the present. As an antihypertensive agent, a thiazide-type diuretic drug is used in many cases. Use of furosemide is not recommended other than a chronic kidney disease patient. Considering future medical economics, it is desirable to use a diuretic drug positively. PMID:25167755

Hirama, Akio; Tsuruoka, Shuichi

2014-08-01

81

Design of a new, multi-purpose, light-curing adhesive comprising a silane coupling agent, acidic adhesive monomers and dithiooctanoate monomers for bonding to varied metal and dental ceramic materials.  

PubMed

A newly designed, light-curing adhesive was investigated for its bonding effectiveness to porcelain, alumina, zirconia, Au, Au alloy, Ag alloy, Au-Ag-Pd alloy, and Ni-Cr alloy. Four experimental adhesives were prepared using varying contents of the following: a silane coupling agent [3-methacryloyloxypropyltriethoxysilane (3-MPTES)], acidic adhesive monomers [6-methacryloyloxyhexyl phosphonoacetate(6-MHPA),6-methacryloyloxyhexyl3-phosphonopropionate(6-MHPP)and 4-methacryloyloxyethoxycarbonylphthalic acid (4-MET)], and dithiooctanoate monomers [6-methacryloyloxyhexyl 6,8-dithiooctanoate (6-MHDT) and 10-methacryloyloxydecyl 6,8-dithiooctanoate (10-MDDT)]. After all adherend surfaces were sandblasted and applied with an experimental adhesive, shear bond strengths (SBSs) of a light-curing resin composite (Beautifil II, Shofu Inc., Kyoto, Japan) to the adherend materials after 2,000 times of thermal cycling were measured. For the experimental adhesive which contained 3-MPTES (30.0 wt%), 6-MHPA (1.0 wt%), 6-MHPP (1.0 wt%), 4-MET (1.0 wt%), 6-MHDT (0.5 wt%) and 10-MDDT (0.5 wt%), it consistently yielded the highest SBS for all adherend surfaces in the range of 20.8 (4.8)-30.3 (7.9) MPa, with no significant differences among all the adherend materials (p>0.05). Therefore, the newly designed, multi-purpose, light-curing adhesive was able to deliver high SBS to all the adherend materials tested. PMID:21778601

Ikemura, Kunio; Tanaka, Hisaki; Fujii, Toshihide; Deguchi, Mikito; Negoro, Noriyuki; Endo, Takeshi; Kadoma, Yoshinori

2011-01-01

82

A Dynamical Systems Perspective on Agent-Environment Interaction  

Microsoft Academic Search

Using the language of dynamical systems theory, a general theoretical framework for the synthesis and analysis of autonomous agents is sketched. In this framework, an agent and its environment are modeled as two coupled dynamical systems whose mutual interaction is in general jointly responsible for the agent's behavior. In addition, the adaptive fit between an agent and its environment is

Randall D. Beer

1995-01-01

83

Antidiabetic Agents.  

ERIC Educational Resources Information Center

This module on antidiabetic agents is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

Plummer, Nancy; Michael, Nancy, Ed.

84

Alkylating Agents  

Microsoft Academic Search

\\u000a Alkylating agents were the first anticancer molecules developed and are still used today. The family contains 6 major classes:\\u000a nitrogen mustards, aziridines, alkyl sulfonates, epoxides, nitrosoureas and triazene compounds. Due to their chemical properties,\\u000a these drugs can, either directly or after biological activation react and form covalent bonds with macromolecules such as\\u000a DNA, RNA and proteins. Their cytotoxic properties are

Laurent Gate; Kenneth D. Tew

85

Antiparasitic agents.  

PubMed

Several important developments have occurred in recent years in the chemotherapy for and prophylaxis of parasitic infections. Although mefloquine is clearly the most effective agent for prevention of chloroquine-resistant falciparum malaria, its use has been compromised by side effects, both real and imagined. Well-designed studies have shown that side effects occur no more frequently with low-dose mefloquine than with chloroquine. Use of mefloquine in pregnant women has not been associated with birth defects, but the incidence of stillbirths may be increased. Malarone is a new agent that combines atovaquone and proguanil, and it may be as effective as mefloquine; however, it is not yet available in the United States. Several newer agents have appeared in response to the development of multidrug resistant Plasmodium falciparum, especially in Southeast Asia. Halofantrine is available for the treatment of mild to moderate malaria due to P. falciparum and for P. vivax infections. Because of severe toxic effects, use of halofantrine should be restricted to only those unusual and rare situations in which other agents cannot be used. Artemisinin (an extract of the Chinese herbal remedy qinghaosu) and two derivatives, artesunate and artemether, are active against multidrug resistant P. falciparum and are widely used in Asia in oral, parenteral, and rectal forms. The antibacterial azithromycin in combination with atovaquone or quinine has now been reported to treat babesiosis effectively in experimental animals and in a few patients. Azithromycin in combination with paromomycin has also shown promise in the treatment of cryptosporidiosis (and toxoplasmosis when combined with pyrimethamine) in patients with the acquired immunodeficiency syndrome (AIDS). Albendazole is currently the only systemic agent available for treatment of microsporidiosis, an infection primarily of patients with AIDS. In addition, albendazole and ivermectin have emerged as effective broad-spectrum antihelminthics, with albendazole becoming the drug of choice for hydatid disease (echinococcosis), neurocysticercosis, and most intestinal nematode infections (except strongyloidiasis and trichuriasis). Liposomal amphotericin B is the first drug approved by the Food and Drug Administration for the treatment of visceral leishmaniasis. PMID:10560606

Rosenblatt, J E

1999-11-01

86

Multi-agent systems  

Microsoft Academic Search

Structurally, an agent is a bundle of sensors, decision-makers and actuators. Behaviorally, an agent is a mapping from an in-space (the set of things the agent can sense) to an out-space (the set of things the agent can affect). Cells, ants, computer programs, robots and people are examples of agents. Larger agents (multi-agent systems) are organizations of lesser agents. Immune

S. Talukdar

2004-01-01

87

Using Constraints and Process Algebra for Specification of First-Class Agent Interaction  

E-print Network

within an agent strongly couples the agent and the protocols it uses, which means a change to a protocol involves a changes in any agent that uses such a protocol; agents can use only the protocols that are coded their behaviour to changing conditions. Despite this, research into interaction in multi-agent systems is focused

Atkinson, Katie

88

UMBC AgentWeb: Intelligent Software Agents  

NSDL National Science Digital Library

This site, sponsored and maintained by the University of Maryland Baltimore County (UMBC) Laboratory for Advanced Information Technology (LAIT), focuses on intelligent agents, known alternatively as software agents, knowbots, infobots or intentional agents. The site is divided into several parts, some of which are annotated and some of which contain only links to resources. Annotated resources include a bibliography titled Introduction to Agents (under Introductory Material), a list of research projects involving agent technology, and abstracts of and links to articles on a variety of topics such as Agents and Security and Agents in Manufacturing.

89

13 CFR 107.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2011 CFR

...Central Registration Agent, Selling Agent and Fiscal Agent. ...SMALL BUSINESS INVESTMENT COMPANIES SBA Financial Assistance...Central Registration Agent, Selling Agent and Fiscal Agent. ...pursuant to this part. (1) Selling Agent. As a...

2011-01-01

90

7 CFR 4290.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2011 CFR

...Central Registration Agent, Selling Agent and Fiscal Agent. ...RURAL BUSINESS INVESTMENT COMPANY (âRBICâ) PROGRAM Financial...Central Registration Agent, Selling Agent and Fiscal Agent. ...pursuant to this part. (1) Selling Agent. As a condition...

2011-01-01

91

Detecting agents.  

PubMed Central

This paper reviews a recent set of behavioural studies that examine the scope and nature of the representational system underlying theory-of-mind development. Studies with typically developing infants, adults and children with autism all converge on the claim that there is a specialized input system that uses not only morphological cues, but also behavioural cues to categorize novel objects as agents. Evidence is reviewed in which 12- to 15-month-old infants treat certain non-human objects as if they have perceptual/attentional abilities, communicative abilities and goal-directed behaviour. They will follow the attentional orientation of an amorphously shaped novel object if it interacts contingently with them or with another person. They also seem to use a novel object's environmentally directed behaviour to determine its perceptual/attentional orientation and object-oriented goals. Results from adults and children with autism are strikingly similar, despite adults' contradictory beliefs about the objects in question and the failure of children with autism to ultimately develop more advanced theory-of-mind reasoning. The implications for a general theory-of-mind development are discussed. PMID:12689380

Johnson, Susan C

2003-01-01

92

Mother ship and physical agents collaboration  

NASA Astrophysics Data System (ADS)

This paper discusses ongoing research at the U.S. Army Research Laboratory that investigates the feasibility of developing a collaboration architecture between small physical agents and a mother ship. This incudes the distribution of planning, perception, mobility, processing and communications requirements between the mother ship and the agents. Small physical agents of the future will be virtually everywhere on the battlefield of the 21st century. A mother ship that is coupled to a team of small collaborating physical agents (conducting tasks such as Reconnaissance, Surveillance, and Target Acquisition (RSTA); logistics; sentry; and communications relay) will be used to build a completely effective and mission capable intelligent system. The mother ship must have long-range mobility to deploy the small, highly maneuverable agents that will operate in urban environments and more localized areas, and act as a logistics base for the smaller agents. The mother ship also establishes a robust communications network between the agents and is the primary information disseminating and receiving point to the external world. Because of its global knowledge and processing power, the mother ship does the high-level control and planning for the collaborative physical agents. This high level control and interaction between the mother ship and its agents (including inter agent collaboration) will be software agent architecture based. The mother ship incorporates multi-resolution battlefield visualization and analysis technology, which aids in mission planning and sensor fusion.

Young, Stuart H.; Budulas, Peter P.; Emmerman, Philip J.

1999-07-01

93

Intelligence artificielle Agents intelligents  

E-print Network

Intelligence artificielle Agents intelligents Elise Bonzon http://web.mi.parisdescartes.fr/ bonzon´e Paris Descartes 1 / 21 Intelligence artificielle #12;Agents intelligents Agents intelligents Agents et environnement Rationalit´e PEAS Types d'environnement Structure des agents Conclusion 2 / 21 Intelligence

Bonzon, Elise

94

Remote Agent Demonstration  

NASA Technical Reports Server (NTRS)

We describe the computer demonstration of the Remote Agent Experiment (RAX). The Remote Agent is a high-level, model-based, autonomous control agent being validated on the NASA Deep Space 1 spacecraft.

Dorais, Gregory A.; Kurien, James; Rajan, Kanna

1999-01-01

95

Helix coupling  

DOEpatents

A coupling for connecting helix members in series, which consists of a pair of U-shaped elements, one of which is attached to each helix end with the U sections of the elements interlocked. The coupling is particularly beneficial for interconnecting helical Nitinol elements utilized in thermal actuators or engines. Each coupling half is attached to the associated helix at two points, thereby providing axial load while being easily removed from the helix, and reusable.

Ginell, W.S.

1982-03-17

96

Spacecraft sanitation agent development  

NASA Technical Reports Server (NTRS)

The development of an effective sanitizing agent that is compatible with the spacecraft environment and the human occupant is discussed. Experimental results show that two sanitation agents must be used to satisfy mission requirements: one agent for personal hygiene and one for equipment maintenance. It was also recommended that a water rinse be used with the agents for best results, and that consideration be given to using the agents pressure packed or in aerosol formulations.

1972-01-01

97

13 CFR 108.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2011 CFR

...Assistance for NMVC Companies (Leverage) Funding...Registration Agent, Selling Agent and Fiscal Agent...this part. (1) Selling Agent. As a condition...may cause each NMVC Company to appoint a Selling Agent to perform...

2011-01-01

98

The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole - Orbitrap mass spectrometry.  

PubMed

A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole - high resolution Orbitrap mass spectrometry (UPLC-qOrbitrap). The sample preparation included extraction of two analytical portions with acetonitrile and 5% trichloroacetic acid, respectively, followed by centrifugation and filtration. The method was validated over three days at 50% of MRL (maximum residue limit) set in the European Union. Experiments on spiked meat and milk samples showed that the average recovery of the antibiotics ranged from 83% to 112%, and the coefficients of variation were between 8.9% and 39%. PMID:25282600

Cepurnieks, Guntis; Rjabova, Jekaterina; Zacs, Dzintars; Bartkevics, Vadims

2015-01-01

99

Synchronization of mobile chaotic agents on connected networks  

NASA Astrophysics Data System (ADS)

This work studies the synchronization of a number of mobile agents on a substrate network. Each agent carries a chaotic map and randomly walks on a connected network. The collection of agents consists of another time-varying network derived from the substrate network. It is found that the synchronization conditions of this agent network depend on the average degree of the substrate network’s connectivity, the coupling strength between interacting agents, and the agent density in the network. Synchronization of the agent network on scale-free and ER networks is considered here, and it is found that the scale-free topology is more applicable to synchronize mobile chaotic agents. To get analytical insights, the star graph is taken and considered as a substrate network.

Bu, Shou-Liang; Wen, Jian-Ping; Zhong, Qing-Hu; Yi, Xue-Hua

2013-12-01

100

Contrast agent for radiography  

US Patent & Trademark Office Database

A lanthanide phosphate provides a contrast agent useful in radiographic contrast compositions and surgical elements. Radiographic imaging methods which employ this contrast agent and methods of making lanthanide phosphate-containing radiographic contrast compositions are also disclosed.

1982-01-12

101

Riot Control Agents  

MedlinePLUS

... exposed to riot control agents. Long-term health effects of exposure to riot control agents Prolonged exposure, ... an enclosed area, may lead to long-term effects such as eye problems including scarring, glaucoma, and ...

102

Health care agents  

MedlinePLUS

... do not have a living will or an advanced directive, your health care agent will be the one ... organs, unless you've stated otherwise in your advance directive Before you choose a health care agent, you ...

103

Biological warfare agents  

Microsoft Academic Search

\\u000a Biological warfare agents are a group of pathogens and toxins of biological origin that can be potentially misused for military\\u000a or criminal purposes. The present review attempts to summarize necessary knowledge about biological warfare agents. The historical\\u000a aspects, examples of applications of these agents such as anthrax letters, biological weapons impact, a summary of biological\\u000a warfare agents and epidemiology of

Miroslav Pohanka; Kamil Ku?a

104

Agent Oriented Programming  

Microsoft Academic Search

Shoham, Y., Agent-oriented programming, Artificial Intelligence 60 (1993) 51-92. A new computational framework is presented, called agent-oriented programming (AOP), which can be viewed as a specialization of object-oriented programming. The state of an agent consists of components such as beliefs, decisions, capabilities, and obligations; for this reason the state of an agent is called its mental state. The mental state

Yoav Shoham

1992-01-01

105

FRAMEWORK FOR MODELING\\/SIMULATION OF MOBILE AGENT SYSTEMS  

Microsoft Academic Search

The paper presents the formal modeling and simulation framework for mobile agent systems . A Mobile Discrete Event System Specification (MDEVS) formalism is pro- posed to represent the dynamics of mobile agent systems . The MDEVS formalism supports the structural changes of systems that include creation, addition, deletion, and migra- tion of models and the dynamic changes of couplings be-

Jae-Hyun Kim; Tag Gon Kim

106

Artificial Intelligence Intelligent Agents  

E-print Network

-agents" ? #12;Agents and Environments · The agent function maps from percept histories to actions: [f: P* A, customers ­ Actuators: Steering wheel, accelerator, brake, signal, horn ­ Sensors: Cameras, sonar · Actuators: Screen display (questions, tests, diagnoses, treatments, referrals) · Sensors: Keyboard (entry

Voris, Jonathan

107

Hydroxypyridonate chelating agents  

DOEpatents

Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided.

Raymond, Kenneth N. (Berkeley, CA); Scarrow, Robert C. (Minneapolis, MN); White, David L. (Oakland, CA)

1987-01-01

108

Hydroxypyridonate chelating agents  

SciTech Connect

Chelating agents are disclosed having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided.

Raymond, K.N.; Scarrow, R.C.; White, D.L.

1987-10-06

109

MOBILE AGENTS AND SECURITY  

Microsoft Academic Search

Mobile agent technology offers a new computing paradigm in which a software agent can suspend its execution on a host computer, transfer itself to another agent-enabled host on the network, and resume execution on the new host. The use of mobile code has a long history dating back to the use of remote job entry systems in the 1960's. Today's

W. A. Jansen

1999-01-01

110

APP: AGENT PLANNING PACKAGE  

Microsoft Academic Search

C† Abstract. Nowadays, a large number of planning systems exist. The majority of them are either applicable only to specific domains (domain dependent) or support only plan generation, but not plan execution and supervision. This paper presents Agent Planning Package (APP), a new domain independent planner which facilitates the creation of intelligent agents. Through the use of APP, agents can

S RADOVANOVI ´ C

111

APP: Agent Planning Package  

Microsoft Academic Search

Summary. Nowadays, a large number of planning systems exist. The majority of them are either applicable only to specific domains (domain dependent) or support only plan gener- ation, but not plan execution and supervision. This paper presents Agent Planning Package (APP), a new domain independent planner which facilitates the creation of intelligent agents. Through the use of APP, agents can

Sasa Tosi; Milos Radovanovi; Mirjana Ivanovic

112

BIOLOGICAL AND SYNTHETIC AGENTS  

E-print Network

#12;INSECT CONTROL BIOLOGICAL AND SYNTHETIC AGENTS #12;This page intentionally left blank #12;INSECT CONTROL BIOLOGICAL AND SYNTHETIC AGENTS EDITED BY LAWRENCE I. GILBERT SARJEET S. GILL Amsterdam://www.elsevier.com/locate/permissions). Library of Congress Cataloging-in-Publication Data Insect control : biological and synthetic agents

Hammock, Bruce D.

113

Whole Body Cleansing Agent.  

National Technical Information Service (NTIS)

The subject invention relates to a human cleansing agent particularly suitable for use in long duration spaceflight and a method of bathing with the agent. The agent of the subject invention is in the form of a paste having a pH of 5.0 to 7.9 which compri...

S. E. Lentsch

1990-01-01

114

Agents modeling agents in information economies  

SciTech Connect

Our goal is to design and build agents that act intelligently when placed in an agent-based information economy, where agents buy and sell services (e.g. thesaurus, search, task planning services, etc.). The economy we are working in is the University of Michigan Digital Library (UMDL), a large scale multidisciplinary effort to build an infrastructure for the delivery of library services. In contrast with a typical economy, an information economy deals in goods and services that are often derived from unique sources (authors, analysts, etc.), so that many goods and services are not interchangeable. Also, the cost of replicating and transporting goods is usually negligible, and the quality of goods and services is difficult to measure objectively: even two sources with essentially the same information might appeal to different audiences. Thus, each agent has its own assessment of the quality of goods and services delivered.

Vidal, J.M.; Durfee, E.H. [Univ. of Michigan, Ann Arbor, MI (United States)

1996-12-31

115

Multi-agent autonomous system  

NASA Technical Reports Server (NTRS)

A multi-agent autonomous system for exploration of hazardous or inaccessible locations. The multi-agent autonomous system includes simple surface-based agents or craft controlled by an airborne tracking and command system. The airborne tracking and command system includes an instrument suite used to image an operational area and any craft deployed within the operational area. The image data is used to identify the craft, targets for exploration, and obstacles in the operational area. The tracking and command system determines paths for the surface-based craft using the identified targets and obstacles and commands the craft using simple movement commands to move through the operational area to the targets while avoiding the obstacles. Each craft includes its own instrument suite to collect information about the operational area that is transmitted back to the tracking and command system. The tracking and command system may be further coupled to a satellite system to provide additional image information about the operational area and provide operational and location commands to the tracking and command system.

Fink, Wolfgang (Inventor); Dohm, James (Inventor); Tarbell, Mark A. (Inventor)

2010-01-01

116

Optical coupling  

Microsoft Academic Search

This paper describes contributions to the CMBpol Technology Study Workshop concerning optical coupling structures. These are structures in or near the focal plane which convert the free space wave to a superconducting microstrip on a SI wafer, or to the waveguide input to a HEMT receiver. In addition to an introduction and conclusions by the editor, this paper includes independent

J. J. Bock; J. Gundersen; A. T. Lee; P. L. Richards; E. Wollack

2009-01-01

117

IM Free Agent Sign Up 1 Wanted! Intramurals Free Agents!  

E-print Network

IM Free Agent Sign Up 1 Wanted! Intramurals Free Agents! Individuals who do not have a full team a "Free Agent". Within the UNLV Intramural Sports program there are multiple ways to improve a Free Agent will not force any team to accept a Free Agent participant. History and research has shown that Free Agents

Hemmers, Oliver

118

Agent Architectures for Compliance  

NASA Astrophysics Data System (ADS)

A Normative Multi-Agent System consists of autonomous agents who must comply with social norms. Different kinds of norms make different assumptions about the cognitive architecture of the agents. For example, a principle-based norm assumes that agents can reflect upon the consequences of their actions; a rule-based formulation only assumes that agents can avoid violations. In this paper we present several cognitive agent architectures for self-monitoring and compliance. We show how different assumptions about the cognitive architecture lead to different information needs when assessing compliance. The approach is validated with a case study of horizontal monitoring, an approach to corporate tax auditing recently introduced by the Dutch Customs and Tax Authority.

Burgemeestre, Brigitte; Hulstijn, Joris; Tan, Yao-Hua

119

DCTD — Featured Agents  

Cancer.gov

The “Featured Agents” portion of the DCTD Website provides information for researchers involved in drug discovery and development. Any public preclinical and clinical data that DCTD has on a particular agent are presented here. New agents will be added periodically to the current list. DCTD Website visitors may subscribe to the Listserv on this page to be notified when additions to the list are made.

120

DCTD — Featured Agents  

Cancer.gov

DNA damaging agents are among the most successful treatments for cancer. The enzyme Poly(ADP-ribose)polymerase (abbreviated PARP) can facilitate repair of DNA damage caused by insult from chemotherapeutic agents and radiation. Increased PARP activity is associated with survival of some cancer cells. ABT-888, an orally bioavailable PARP-inhibitor developed by Abbott Laboratories, significantly enhanced the antitumor activity of DNA-damaging agents and radiation in preclinical models. Further development of this compound is ongoing.

121

APP: Agent Planning Package  

Microsoft Academic Search

\\u000a Nowadays, a large number of planning systems exist. The majority of them are either applicable only to specific domains (domain\\u000a dependent) or support only plan generation, but not plan execution and supervision. This paper presents Agent Planning Package\\u000a (APP), a new domain independent planner which facilitates the creation of intelligent agents. Through the use of APP, agents\\u000a can generate plans

Saša Toši?; Miloš Radovanovi?; Mirjana Ivanovi?

122

Interactive agent generated architecture  

E-print Network

The thesis explores architectural form generation through two behavior based artificial intelligence approaches: the communication of agents in an unpredictable simulation system, and the codification of information within ...

Krause, Jeffrey Charles Stanley

1996-01-01

123

Healthcare Agents: Being One  

MedlinePLUS

Planning Ahead > Advance Directives Advance Directives Download Your State's Advance Directives What are Advance Directives? Healthcare Agents: Four Quick Steps to Naming Someone to Speak4me Healthcare ...

124

Joint chemical agent detector (JCAD): the future of chemical agent detection  

NASA Astrophysics Data System (ADS)

The Joint Chemical Agent Detector (JCAD) has continued development through 2002. The JCAD has completed Contractor Validation Testing (CVT) that included chemical warfare agent testing, environmental testing, electromagnetic interferent testing, and platform integration validation. The JCAD provides state of the art chemical warfare agent detection capability to military and homeland security operators. Intelligence sources estimate that over twenty countries have active chemical weapons programs. The spread of weapons of mass destruction (and the industrial capability for manufacture of these weapons) to third world nations and terrorist organizations has greatly increased the chemical agent threat to U.S. interests. Coupled with the potential for U.S. involvement in localized conflicts in an operational or support capacity, increases the probability that the military Joint Services may encounter chemical agents anywhere in the world. The JCAD is a small (45 in3), lightweight (2 lb.) chemical agent detector for vehicle interiors, aircraft, individual personnel, shipboard, and fixed site locations. The system provides a common detection component across multi-service platforms. This common detector system will allow the Joint Services to use the same operational and support concept for more efficient utilization of resources. The JCAD detects, identifies, quantifies, and warns of the presence of chemical agents prior to onset of miosis. Upon detection of chemical agents, the detector provides local and remote audible and visual alarms to the operators. Advance warning will provide the vehicle crew and other personnel in the local area with the time necessary to protect themselves from the lethal effects of chemical agents. The JCAD is capable of being upgraded to protect against future chemical agent threats. The JCAD provides the operator with the warning necessary to survive and fight in a chemical warfare agent threat environment.

Laljer, Charles E.

2003-08-01

125

Measuring Software Agent's Intelligence  

Microsoft Academic Search

This paper outlines a methodology to test agent's intelligence using the general intelligence factor (factor g) and the theory of multiple intelligence in humans. The method presented is also based on the evolutionary theory and deals with knowledge as a kind of stored intelligence. A set of tests assess the multiple intelligences of the agents analyzing their behavior and performance

Dino Franklin; Ana Abrao

126

Etiological agents of diarrhoea.  

PubMed

Two decades of research have established newer pathogens and techniques in establishing several organisms of diarrhoeal diseases as aetiological agents. It is now possible to detect an agent in 80% of the situation of diarrhoea in a standard laboratory. The brief review describes the list of pathogens, their diagnostic techniques with short description on clinical and epidemiological status. PMID:2101388

Ghosh, A R; Paul, M; Pal, S C; Sen, D

1990-01-01

127

Change Agent Survival Guide  

ERIC Educational Resources Information Center

Consulting is a rough racket. Only a tarantula hair above IRS agents, meter maids and used car sales people, the profession is a prickly burr for slings and arrows. Throw in education, focus on dysfunctional schools and call oneself a "change agent," and this bad rap all but disappears. Unfortunately, though, consulting/coaching/mentoring in…

Dunbar, Folwell L.

2011-01-01

128

Delegating to software agents  

Microsoft Academic Search

Summary There is currently a great deal of interest in the development of intelligent agents. While there is little agreement on exactly what constitutes an intelligent agent, many definitions embody a user interface model that differs from the traditional one where users perform tasks with the help of computer-based \\

Allen E. Milewski; Steven H. Lewis

1997-01-01

129

Discoveries Change Agents  

E-print Network

Discoveries Change Agents A new kind of researcher moves from practice to research to policy) "is to graduate `change agents' who are able to bridge the worlds of research and academia, clinical in this area presently." That situation is changing because of the Scholars in HeAlth Research Program (SHARP

Shihadeh, Alan

130

DCTD — Featured Agents  

Cancer.gov

Skip to Content Click here to view the Site Map Home | Sitemap | Contact DCTD Search this site Featured Agents Agents NCI Experimental Therapeutics (NExT) Program Drug Development Primer FDA-Approved Cancer Drugs DCTD Programs Cancer Diagnosis Program Cancer

131

Pediatric Antifungal Agents  

PubMed Central

Purpose of review In immunocompromised hosts, invasive fungal infections are common and fatal. In the past decade, the antifungal armamentarium against invasive mycoses has expanded greatly. The purpose of this report is to review the most recent literature addressing the use of antifungal agents in children. Recent findings Most studies evaluating the safety and efficacy of antifungal agents are limited to adults. However, important progress has been made in describing the pharmacokinetics and safety of newer antifungal agents in children, including the echinocandins. Summary Dosage guidelines for newer antifungal agents are currently based on adult and limited pediatric data. Because important developmental pharmacology changes occur throughout childhood impacting the pharmacokinetics of these agents, antifungal studies specifically designed for children are necessary. PMID:19741525

Cohen-Wolkowiez, Michael; Moran, Cassandra; Benjamin, Daniel K.; Smith, P Brian

2009-01-01

132

How do agents represent?  

NASA Astrophysics Data System (ADS)

Representation is inherent to the concept of an agent, but its importance in complex systems has not yet been widely recognised. In this paper I introduce Peirce's theory of signs, which facilitates a definition of representation in general. In summary, representation means that for some agent, a model is used to stand in for another entity in a way that shapes the behaviour of the agent with respect to that entity. Representation in general is then related to the theories of representation that have developed within different disciplines. I compare theories of representation from metaphysics, military theory and systems theory. Additional complications arise in explaining the special case of mental representations, which is the focus of cognitive science. I consider the dominant theory of cognition — that the brain is a representational device — as well as the sceptical anti-representational response. Finally, I argue that representation distinguishes agents from non-representational objects: agents are objects capable of representation.

Ryan, Alex

133

Agent-Based Computing and Programming of Agent Systems  

E-print Network

, drawing on the recently-published AgentLink III Roadmap of Agent Based Computing Technologies. 1, and addressing these challenges will be crucial for the development of agent technologies. We discuss Introduction Since Shoham's seminal paper [14] on agent-oriented programming in 1993, pro- gramming of agent

Luck, Michael

134

Agent-based Computing and Programming of Agent Systems  

E-print Network

, drawing on the recently-published AgentLink III Roadmap of Agent Based Computing Technologies. 1, and addressing these challenges will be crucial for the development of agent technologies. We discuss Introduction Since Shoham's seminal paper [14] on agent-oriented programming in 1993, pro- gramming of agent

McBurney, Peter

135

Joint Chemical Agent Detector (JCAD): the future of chemical agent detection  

NASA Astrophysics Data System (ADS)

The Joint Chemical Agent Detector (JCAD) will provide state of the art chemical warfare agent detection capability to ground vehicle operators. Intelligence sources estimate that over twenty counties have active chemical weapons programs. The spread of chemical weapons to third world nations, coupled with the potential for US involvement in these areas in an operational or support capacity, increases the probability that the Joint Services may encounter chemical agents and toxic industrial materials anywhere in the world. Currently, fielded chemical agent detectors are bulky, labor intensive, and subject to false readings. No legacy detector is sensitive enough to provide detection and warning of the low dose hazards associated with miosis contamination. The JCAD will provide a small, lightweight chemical agent detector for vehicle interiors, aircraft, individual personnel, shipboard, and fixed site locations. The system provides a common detection components across multi-service platforms. This common detector system will allow the Joint Services to use the same operational and support concept for more efficient utilization of resources. The JCAD will detect, identify, quantify, and warn of the presence of chemical agents prior to onset of miosis. Upon detection of chemical agents, the detector will provide local and remote audible and visual alarms to the operators. Advance warning will provide the vehicle crew with the time necessary to protect themselves from the lethal effects of chemical agents. The JCAD will also be capable of being upgraded to protect against future chemical agent threats. The JCAD will provide the vehicle operators with the warning necessary to survive and fight in a chemical warfare agent threat environment.

Laljer, Charles E.; Owen, Jeffery L.

2002-06-01

136

Wood-Fiber/High-Density-Polyethylene Composites: Coupling Agent Performance  

E-print Network

-of-service thermoplastic products and plastic wastes in the world.3 Like other thermoplastic olefins, virgin and recycled and nonpolar thermoplastic ma- trix.5,6 Kokta and coworkers7 investigated the influ- ence of four different

137

Novel Phenylethynyl Imide Silanes as Coupling Agents for Titanium Alloy  

NASA Technical Reports Server (NTRS)

The durability of titanium (Ti) alloys bonded with high temperature adhesives such as polyimides has failed to attain the level of performance required for many applications. The problem to a large part is attributed to the instability of the surface treatment on the Ti substrate. Although Ti alloy adhesive specimens with surface treatments such as chromic acid anodization, Pasa-Jell, Turco, etc. have provided high initial mechanical properties, these properties have decreased as a function of aging at ambient temperature and faster, when aged at elevated temperatures or in a hot-wet environment. As part of the High Speed Civil Transport program where Ti honeycomb sandwich structure must perform for 60,000 hours at 177 C, work was directed to the development of environmentally safe, durable Ti alloy surface treatments.

Park, C.; Lowther, S. E.; Smith, J. G., Jr.; Conell, J. W.; Hergenrother, P. M.; SaintClair, T. L.

2004-01-01

138

Agents on the Web Philosophical  

E-print Network

Agents on the Web Philosophical Agents T he improvements in Internet-based software agents software agents? We think it will be reasonable to endow agents with a phi- losophy. Then, by understanding. As they become longer, more complicated, and farther away, the software systems controlling them

Huhns, Michael N.

139

Dioxin, agent orange  

SciTech Connect

This book presents information on the following topics: dioxin, a prevalent problem; nobody wanted dioxin; agent organe and Vietnam; what we know about and may learn about agent orange and Veterans' health; agent organe and birth defects; dioxin in Missouri; 2, 4, 5-T: the U.S.' disappearing herbicide; Seveso: high-level environmental exposure; the nitro explosion; industrial exposures to dioxin; company behavior in the face of dioxin exposures; dioxin and specific cancers; animal tests of dioxin toxicity; dioxin decions; the present and the future.

Gough, M.

1986-01-01

140

Dark coupling  

SciTech Connect

The two dark sectors of the universe—dark matter and dark energy—may interact with each other. Background and linear density perturbation evolution equations are developed for a generic coupling. We then establish the general conditions necessary to obtain models free from non-adiabatic instabilities. As an application, we consider a viable universe in which the interaction strength is proportional to the dark energy density. The scenario does not exhibit ''phantom crossing'' and is free from instabilities, including early ones. A sizeable interaction strength is compatible with combined WMAP, HST, SN, LSS and H(z) data. Neutrino mass and/or cosmic curvature are allowed to be larger than in non-interacting models. Our analysis sheds light as well on unstable scenarios previously proposed.

Gavela, M.B.; Hernández, D.; Honorez, L. Lopez [Departamento de Física Teórica and Instituto de Física Teórica, Universidad Autónoma de Madrid, 28049 Cantoblanco, Madrid (Spain); Mena, O. [Instituto de Física Corpuscular, IFIC, CSIC and Universidad de Valencia, Valencia (Spain); Rigolin, S., E-mail: belen.gavela@uam.es, E-mail: d.hernandez@uam.es, E-mail: laura.lopez@uam.es, E-mail: omena@ific.uv.es, E-mail: stefano.rigolin@pd.infn.it [Dipartimento d Fisica ''Galileo Galilei'', Universitá di Padova, via Marzolo 8, I-35131 Padova (Italy)

2009-07-01

141

Agent oriented programming  

NASA Technical Reports Server (NTRS)

The goal of our research is a methodology for creating robust software in distributed and dynamic environments. The approach taken is to endow software objects with explicit information about one another, to have them interact through a commitment mechanism, and to equip them with a speech-acty communication language. System-level applications include software interoperation and compositionality. A government application of specific interest is an infrastructure for coordination among multiple planners. Daily activity applications include personal software assistants, such as programmable email, scheduling, and new group agents. Research topics include definition of mental state of agents, design of agent languages as well as interpreters for those languages, and mechanisms for coordination within agent societies such as artificial social laws and conventions.

Shoham, Yoav

1994-01-01

142

Instructable Autonomous Agents.  

National Technical Information Service (NTIS)

In contrast to current intelligent systems, which must be laboriously programmed for each task they are meant to perform, instructable agents can be taught new tasks and associated knowledge. This thesis presents a general theory of learning from tutorial...

S. B. Huffman

1994-01-01

143

Agent and environment  

E-print Network

This paper is about how agents learn. There is a picture of learning that is very influential in epistemology; I call it 'the Classical Picture'. As influential as it is, it is a flawed picture of learning, and epistemology ...

Rochford, Damien (Damien Joseph)

2013-01-01

144

Chemopreventive Agent Development  

Cancer.gov

This group promotes and supports research on early chemopreventive agent development, from preclinical studies to phase I clinical trials. The focus is to identify and develop agents with the potential to help detect, block, reverse, or delay early stages of cancer. Preclinical studies evaluate potential new drugs and combinations in model systems using emergent knowledge of genetic and biochemical mechanisms, while early phase trials emphasize pharmacokinetics, efficacy, and safety.

145

Autonomy of Autonomous Agents  

Microsoft Academic Search

Autonomy is one of the most notable attributes of agency, and this paper presents a formal framework for modelling it. By\\u000a representing the mental states of agents, we provide an analysis of some attributes of autonomy. In particular, we define\\u000a three sorts of autonomous agents and examine their structure. We also outline features of higher autonomy. Our framework can\\u000a be

Dongmo Zhang; Norman Y. Foo

2000-01-01

146

Agent amplified communication  

SciTech Connect

We propose an agent-based framework for assisting and simplifying person-to-person communication for information gathering tasks. As an example, we focus on locating experts for any specified topic. In our approach, the informal person-to-person networks that exist within an organization are used to {open_quotes}referral chain{close_quotes} requests for expertise. User-agents help automate this process. The agents generate referrals by analyzing records of e-mail communication patterns. Simulation results show that the higher responsiveness of an agent-based system can be effectively traded for the higher accuracy of a completely manual approach. Furthermore, preliminary experience with a group of users on a prototype system has shown that useful automatic referrals can be found in practice. Our experience with actual users has also shown that privacy concerns are central to the successful deployment of personal agents: an advanced agent-based system will therefore need to reason about issues involving trust and authority.

Kautz, H.; Selman, B.; Milewski, A. [AT& T Laboratories, Murray Hill, NJ (United States)

1996-12-31

147

Agent independent task planning  

NASA Technical Reports Server (NTRS)

Agent-Independent Planning is a technique that allows the construction of activity plans without regard to the agent that will perform them. Once generated, a plan is then validated and translated into instructions for a particular agent, whether a robot, crewmember, or software-based control system. Because Space Station Freedom (SSF) is planned for orbital operations for approximately thirty years, it will almost certainly experience numerous enhancements and upgrades, including upgrades in robotic manipulators. Agent-Independent Planning provides the capability to construct plans for SSF operations, independent of specific robotic systems, by combining techniques of object oriented modeling, nonlinear planning and temporal logic. Since a plan is validated using the physical and functional models of a particular agent, new robotic systems can be developed and integrated with existing operations in a robust manner. This technique also provides the capability to generate plans for crewmembers with varying skill levels, and later apply these same plans to more sophisticated robotic manipulators made available by evolutions in technology.

Davis, William S.

1990-01-01

148

Cooperation of Computational Intelligence Agents  

Microsoft Academic Search

In this paper, a multi agent platform targeted toward the area of computational intelligence modeling is presented. We show the design of various computational agents creating multi agent systems, as well as the infrastructure capabilities. The focus of the system is the cooperation of agents, their interchangeability autonomous behavior, and emergence of new models. Two main areas of cooperation are

Roman Neruda

2006-01-01

149

13 CFR 107.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Functions of agents, including Central Registration...Certificates (âtcsâ) § 107.1620 Functions of agents, including Central Registration...to be appointed agent(s) to perform functions necessary to market and service...

2010-01-01

150

7 CFR 4290.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Functions of agents, including Central Registration...Certificates (âtcsâ) § 4290.1620 Functions of agents, including Central Registration...to be appointed agent(s) to perform functions necessary to market and service...

2010-01-01

151

13 CFR 108.1620 - Functions of agents, including Central Registration Agent, Selling Agent and Fiscal Agent.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Functions of agents, including Central Registration...Certificates (âtcsâ) § 108.1620 Functions of agents, including Central Registration...to be appointed agent(s) to perform functions necessary to market and service...

2010-01-01

152

Autonomous Interface Agents Henry Lieberman  

E-print Network

, autonomous agents, Web, browsing, search, learning. I NTRODUCT I ON The definition of an agent is the subjectAutonomous Interface Agents Henry Lieberman Media Laboratory Massachusetts Institute of Technology in operating an interactive interface, and autonomous agents, software that takes action without user

153

Programmability of Intelligent Agent Avatars  

Microsoft Academic Search

In this paper, we propose an approach to the programmabil- ity of intelligent agent avatars, supported by the distributed logic programming language DLP. Intelligent agent avatars can be considered as one of the applications of web agents. As one of the testbeds of 3D web agents, we are developing and implementing soccer playing avatars. We discuss how the language DLP

Zhisheng Huang; Anton Eli; Cees Vissser

2001-01-01

154

Sartobind Epoxy 75 A Microporous Coupling Membrane for Affinity Chromatography  

E-print Network

minutes incubation time for the coupling reaction. Two coupling reactions can be done in parallel making. Important note: The protein sample should not contain nucleophilic agents (e.g. Tris, glycine buffers). Since thiol groups are better nucleophiles than amine and hydroxyl groups, epoxy-activated supports can

Lebendiker, Mario

155

Designing Roles for Situated Agents  

Microsoft Academic Search

Engineering non-trivial open multi-agent systems is a challeng- ing task. Our research focusses on situated multi-agent systems, i.e. systems in which agents are explicitly placed in an environment which agents can per- ceive and in which they can act. Situated agents do not use long-term planning to decide what action sequence should be executed, but select actions based on the

Elke Steegmans; Danny Weyns; Tom Holvoet; Yolande Berbers

2004-01-01

156

SELF-MOTIVATED AUTONOMOUSE AGENTS  

Microsoft Academic Search

In this paper, we describe our design of a behaviour-based control system for autonomous agents with accent on self-control and self-motivation aspects of the agent control. Agents could be represented by simulated agents - animates or by physical robots. The traditional agent behaviour is usually initialised by external signals and motivations. On the other side in the nature systems we

157

Space Travel Agent  

NSDL National Science Digital Library

You are in charge of creating a travel brochure to a planet in our solar system. Travel Agent for the Solar System Introduction You are in charge of the new ?Travel the Solar System? account at Universe Travel Agency.

Williams, Ms.

2010-11-29

158

Agent Amplified Communication  

Microsoft Academic Search

We propose an agent-based framework for assisting and simplifying person-to-person communication for informa- tion gathering tasks. As an example, we focus on expertise location within a large organization. In our approach, the informal person-to-person networks that exist within an or- ganization are used to \\

Henry A. Kautz; Bart Selman; Al Milewski

1996-01-01

159

Research Article Secret Agents  

E-print Network

& Baillargeon, 2000; Leslie & Keeble, 1987) and reasoning about intentional agents in terms of their goals of causal force, the source of motion or change, in an interaction (Leslie, 1994). Adults both distinguish and patient in simple, fully visible inter- actions by 7 to 10 months of age (Leslie, 1984; Leslie & Keeble

Gabrieli, John

160

REMOTE BIOSENSOR FOR IN SITU MONITORING OF ORGANOPHOSPHATE NERVE AGENTS. (R823663)  

EPA Science Inventory

A remote electrochemical biosensor for field monitoring of organophosphate nerve agents is described. The new sensor relies on the coupling of the effective biocatalytic action of organophosphorus hydrolase (OPH) with a submersible amperometric probe design. This combination resu...

161

New antifungal agents.  

PubMed

Two new antifungal agents, voriconazole and caspofungin, are now available for treatment of systemic fungal infections. Voriconazole is an extended-spectrum triazole that is fungicidal for filamentous fungi, including Aspergillus, Scedosporium, Fusarium, Paecilomyces, and is active against all species of Candida. It has become first-line therapy for invasive aspergillosis. Voriconazole is given either by the oral or the intravenous route. Clinicians must be aware of drug-drug interactions and side effects, including visual disturbances and photosensitivity rash that can occur when voriconazole is used. Caspofungin is the first drug available from a new class of antifungal agents, echinocandins, that act to inhibit fungal cell wall synthesis. Caspofungin is fungicidal for all species of Candida and more slowly kills Aspergillus species. Caspofungin, available only for intravenous administration, has minimal side effects and very few drug interactions. The echinocandins will find most use for Candida infections and as second-line therapy for Aspergillus infections. PMID:16088465

Kauffman, Carol A

2004-04-01

162

Diastereoselective pinacol coupling of alkyl aryl ketones with rare earth metals in the presence of chlorosilanes  

Microsoft Academic Search

Rare earth metals (Ln) are found to act as useful reducing agents for the pinacol coupling reaction of alkyl aryl ketones in the presence of chlorosilanes. Although the hitherto known pinacol coupling reaction using rare earth reducing agents generally exhibits very low diastereoselectivities, the present pinacol coupling by use of a LnR3SiCl system usually indicates higher diastereoselectivities. In particular, a

Akiya Ogawa; Hiroki Takeuchi; Toshikazu Hirao

1999-01-01

163

Surface polymerization agents  

SciTech Connect

This is the final report of a 1-year, Laboratory-Directed R&D project at LANL. A joint technical demonstration was proposed between US Army Missile Command (Redstone Arsenal) and LANL. Objective was to demonstrate that an unmanned vehicle or missile could be used as a platform to deliver a surface polymerization agent in such a manner as to obstruct the filters of an air-breathing mechanism, resulting in operational failure.

Taylor, C.; Wilkerson, C.

1996-12-01

164

Rigid bifunctional chelating agents  

DOEpatents

Bicyclo›2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo›2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

Sweet, Mark P. (Coram, NY); Mease, Ronnie C. (Fairfax, VA); Srivastava, Suresh C. (Setauket, NY)

1998-07-21

165

Rigid bifunctional chelating agents  

DOEpatents

Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

Sweet, Mark P. (Coram, NY); Mease, Ronnie C. (Fairfax, VA); Srivastava, Suresh C. (Setauket, NY)

2000-02-08

166

Trusting an Information Agent  

Microsoft Academic Search

: While the common kinds of uncertainties in databases(e.g., null values, disjunction, corrupt\\/missing data, domain mismatch,etc.) have been extensively studied, a relatively unexploredform of uncertainty in databases, called inaccurate data, demandsdue attention. Inaccurate data results when data are contributedby various information agents with some known reliability. Thoughthe data itself is total or complete, the reliability of the data nowdepends on

Hasan M. Jamil; Fereidoon Sadri

1993-01-01

167

REGEN AGENT: A MODULAR AND GENERALIZED FOREST REGENERATION AGENT  

Microsoft Academic Search

This thesis describes the implementation of two software applications: REGEN Agent and REGEN Agent for Excel. REGEN Agent is an expert system and modeling application providing a mechanism for forest regeneration prediction based on the Loftis regeneration model. The Loftis model is both a stochastic and a competitive model that utilizes expert knowledge encoded in a knowledge base and applies

DAVID AGUSTIN BOUCUGNANI

168

AL Amyloidosis and Agent Orange  

MedlinePLUS

... Toll Free Numbers VA » Health Care » Public Health » Military Exposures » Agent Orange » Veterans' Diseases Associated with Agent ... Orange Public Health Public Health Public Health Home Military Exposures Military Exposures Home 4 Ways to Find ...

169

Coupled chaotic chemical oscillators  

Microsoft Academic Search

We present a model study of two mass-coupled reactors containing the Belousov-Zhabotinsky reaction under chaotic conditions. The critical coupling strength is estimated for symmetry breaking when two identical low flow rate chaotic modes are coupled. Our results confirm that the critical coupling strength is directly proportional to the maximum Lyapunov exponent of the uncoupled system. The constant of proportionality is

Milos Dolnik; Irving R. Epstein

1996-01-01

170

Agent-based project scheduling  

Microsoft Academic Search

Agent technology offers a new way of thinking about many of the classic problems in operations research. Among these are problems such as project scheduling subject to resource constraints. In this paper, we develop and experimentally evaluate eight agent-based algorithms for solving the multimode, resource-constrained project scheduling problem. Our algorithms differ in the priority rules used to control agent access

Gary Knotts; Moshe Dror; Bruce C. Hartman

2000-01-01

171

Intention Reconciliation by Collaborative Agents  

Microsoft Academic Search

Research on resource-bounded agents has established that rational agents need to be able to revise their commitments in the light of new opportunities. In the context of collabo- rative activities, rational agents must be able to reconcile their intentions to do team-related actions with other, con- flicting intentions. The SPIRE experimental system allows the process of intention reconciliation in team

David G. Sullivan; Barbara J. Grosz; Sarit Kraus

2000-01-01

172

Environment Monitoring -Robotic Sensor Agents  

E-print Network

- Integrating many sensors into one system can often use many in expensive devices to provide dataEnvironment Monitoring - Robotic Sensor Agents Emil M. Petriu, FIEEE Professor University of Ottawa REALITY ENVIRONMENT WIRELESS COMMUNICATION NETWORK Mobile Robotic Sensor Agent Mobile Robotic Sensor Agent

Petriu, Emil M.

173

Privilege Management of Mobile Agents  

Microsoft Academic Search

Most mobile agent systems use internal data structures within an agent to control and specify its security requirements and properties. These structures typically contain authorization information regarding access to computational resources on distributed systems and conceptually serve as an internal passport for the agent. While these structures are often very similar semantically, they differ greatly in their implementation, depending to

Wayne Jansen; Tom Karygiannis

2000-01-01

174

Dynamical Consensus Algorithm for Second-Order Multi-Agent Systems Subjected to Communication Delay  

NASA Astrophysics Data System (ADS)

To solve the dynamical consensus problem of second-order multi-agent systems with communication delay, delay-dependent compensations are added into the normal asynchronously-coupled consensus algorithm so as to make the agents achieve a dynamical consensus. Based on frequency-domain analysis, sufficient conditions are gained for second-order multi-agent systems with communication delay under leaderless and leader-following consensus algorithms respectively. Simulation illustrates the correctness of the results.

Liu, Cheng-Lin; Liu, Fei

2013-06-01

175

Second-order cluster consensus of multi-agent dynamical systems with impulsive effects  

NASA Astrophysics Data System (ADS)

This paper discuss the cluster consensus of multi-agent dynamical systems (MADSs) with impulsive effects and coupling delays. Some sufficient conditions that guarantee cluster consensus in MADS are derived. In each cluster, agents update their position and velocity states according to a leader's instantaneous information, and interactions among agents are uncertain. Furthermore, switching topology problem in MADS is considered by impulsive stability and adaptive strategy. Finally, numerical simulations are given to verify our theoretical analysis.

Wang, Guan; Shen, Yi

2014-09-01

176

Designing Agent Organisations using a Role Algebra  

Microsoft Academic Search

Multi-agent systems can be viewed as organisations of individual agents. Designing an agent organisation is a complex process involving defining the structural relationships among agents, the lines of inter-agent communication, and the agent functionality. Existing approaches to agent organisation design are difficult to apply in practice since they require the human designer to take design decisions while working at a

Anthony Karageorgos; Simon Thompson; Nikolay Mehandjiev

177

Workshop report: Velocity coupling  

NASA Technical Reports Server (NTRS)

Velocity coupled combustion instability and related combustion instability topics were considered. The knowledge of velocity coupled combustion instability was assessed; the state of the art of velocity coupled measurement techniques was determined; and particularly laboratory devices or T burner related devices; recommendations were made on how to improve the state of knowledge on velocity coupled combustion instability. Test conditions for a round robin of velocity coupled response measurement techniques were established.

Beckstead, M. W.

1980-01-01

178

DCTD — Featured Agents  

Cancer.gov

Tandutinib (MLN518), previously known as CT53518, is a small-molecule inhibitor of the type III receptor tyrosine kinases, including the Fms-like tyrosine kinase 3 receptor (FLT3), platelet-derived growth factor receptor (PDGFR), and c-Kit receptor tyrosine kinase. Tandutinib is relatively selective, having no appreciable activity against EGFR, FGFR, KDR, or several non-receptor kinases. FLT3, c-Kit, and ßPDGFR are equally inhibited by tandutinib, while the agent is much less active against CSF-1R (in vitro IC50 of 3.4 µM).

179

Antithrombotic reversal agents.  

PubMed

The actively bleeding anticoagulated patient presenting to the emergency department requires rapid evaluation and treatment, which is made increasingly complicated by the ever-evolving antithrombotic treatment options used in medicine. Even with excellent supportive care, the timeliness with which reversal decisions need to be made continues to demand of the emergency practitioner a familiarity with the properties and general characteristics of a variety of antithrombotic agents. Reversal options vary and may include vitamin K, FFP, PCC, rFVIIa, platelets, and desmopressin, among others. PMID:25060258

Wilson, Matthew D; Davis, Jonathan E

2014-08-01

180

Sophorolipids as antibacterial agents.  

PubMed

Sophorolipids (SLs), glycolipids produced by yeasts, have been reported to have immunomodulating activity and to reduce the mortality rate in animal models of sepsis. In the present study, the antibacterial activities of SLs and several derivatives were tested against a selection of standard bacterial isolates using the broth microdilution method. The SL derivatives tested did not show any significant antibacterial activity in vitro when tested at clinically relevant concentrations. Most likely the reported decrease of mortality rate in the rat septic shock model was not secondary to antibacterial activity of SLs. The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host's bacterial flora. PMID:19201743

Sleiman, Joseph N; Kohlhoff, Stephan A; Roblin, Patricia M; Wallner, Sabine; Gross, Richard; Hammerschlag, Margaret R; Zenilman, Michael E; Bluth, Martin H

2009-01-01

181

Chemical warfare agents  

PubMed Central

Among the Weapons of Mass Destruction, chemical warfare (CW) is probably one of the most brutal created by mankind in comparison with biological and nuclear warfare. Chemical weapons are inexpensive and are relatively easy to produce, even by small terrorist groups, to create mass casualties with small quantities. The characteristics of various CW agents, general information relevant to current physical as well as medical protection methods, detection equipment available and decontamination techniques are discussed in this review article. A brief note on Chemical Weapons Convention is also provided. PMID:21829312

Ganesan, K.; Raza, S. K.; Vijayaraghavan, R.

2010-01-01

182

Humans as Geomorphic Agents  

NSDL National Science Digital Library

1) The students read an article from the literature on humans as geomorphic agents as an introduction to order-of-magnitude calculations. 2) The class discusses the article in a 50-minute class 3) The students complete a problem set that introduces them to dimensional analysis, walks them through a comparison of the article's results to natural geomorphic rates, and explores how the author derived the article's final numbers. 4) Once the students are done with the problem set, the class discusses the results and implications as a group.

Riihimaki, Catherine

183

CATS-based Air Traffic Controller Agents  

NASA Technical Reports Server (NTRS)

This report describes intelligent agents that function as air traffic controllers. Each agent controls traffic in a single sector in real time; agents controlling traffic in adjoining sectors can coordinate to manage an arrival flow across a given meter fix. The purpose of this research is threefold. First, it seeks to study the design of agents for controlling complex systems. In particular, it investigates agent planning and reactive control functionality in a dynamic environment in which a variety perceptual and decision making skills play a central role. It examines how heuristic rules can be applied to model planning and decision making skills, rather than attempting to apply optimization methods. Thus, the research attempts to develop intelligent agents that provide an approximation of human air traffic controller behavior that, while not based on an explicit cognitive model, does produce task performance consistent with the way human air traffic controllers operate. Second, this research sought to extend previous research on using the Crew Activity Tracking System (CATS) as the basis for intelligent agents. The agents use a high-level model of air traffic controller activities to structure the control task. To execute an activity in the CATS model, according to the current task context, the agents reference a 'skill library' and 'control rules' that in turn execute the pattern recognition, planning, and decision-making required to perform the activity. Applying the skills enables the agents to modify their representation of the current control situation (i.e., the 'flick' or 'picture'). The updated representation supports the next activity in a cycle of action that, taken as a whole, simulates air traffic controller behavior. A third, practical motivation for this research is to use intelligent agents to support evaluation of new air traffic control (ATC) methods to support new Air Traffic Management (ATM) concepts. Current approaches that use large, human-in-the-loop simulations are unquestionably valuable for this purpose, but pose considerable logistical, fiscal, and experimental control problems. First, data analysis is extremely complicated, owing simply to the large number of participants and data sources in such simulations. In addition, experienced human air traffic controllers working adjacent sectors tend to flexibly adapt to the evolving control problem - potentially shifting to other strategies than those under investigation. In addition, their performance is tightly coupled to the control interface, which in the development phase may support some concepts and supporting strategies better than others. A simple shift in strategy by one controller can change the character of a particular traffic scenario dramatically, which makes experimental comparison of ATC performance under different traffic scenarios difficult. Training a given team of controllers on operations under a new ATM concept for a sufficient period of time could avert such difficulties, but instituting an adequate training program is expensive and logistically difficult.

Callantine, Todd J.

2002-01-01

184

Flexible, secure agent development framework  

DOEpatents

While an agent generator is generating an intelligent agent, it can also evaluate the data processing platform on which it is executing, in order to assess a risk factor associated with operation of the agent generator on the data processing platform. The agent generator can retrieve from a location external to the data processing platform an open site that is configurable by the user, and load the open site into an agent substrate, thereby creating a development agent with code development capabilities. While an intelligent agent is executing a functional program on a data processing platform, it can also evaluate the data processing platform to assess a risk factor associated with performing the data processing function on the data processing platform.

Goldsmith; Steven Y. (Rochester, MN)

2009-04-07

185

Learning models of intelligent agents  

SciTech Connect

Agents that operate in a multi-agent system need an efficient strategy to handle their encounters with other agents involved. Searching for an optimal interactive strategy is a hard problem because it depends mostly on the behavior of the others. In this work, interaction among agents is represented as a repeated two-player game, where the agents` objective is to look for a strategy that maximizes their expected sum of rewards in the game. We assume that agents` strategies can be modeled as finite automata. A model-based approach is presented as a possible method for learning an effective interactive strategy. First, we describe how an agent should find an optimal strategy against a given model. Second, we present an unsupervised algorithm that infers a model of the opponent`s automaton from its input/output behavior. A set of experiments that show the potential merit of the algorithm is reported as well.

Carmel, D.; Markovitch, S. [Computer Science Dept., Haifa (Israel)

1996-12-31

186

Holograms as Teaching Agents  

NASA Astrophysics Data System (ADS)

Hungarian physicist Dennis Gabor won the Pulitzer Prize for his 1947 introduction of basic holographic principles, but it was not until the invention of the laser in 1960 that research scientists, physicians, technologists and the general public began to seriously consider the interdisciplinary potentiality of holography. Questions around whether and when Three-Dimensional (3-D) images and systems would impact American entertainment and the arts would be answered before educators, instructional designers and students would discover how much Three-Dimensional Hologram Technology (3DHT) would affect teaching practices and learning environments. In the following International Symposium on Display Holograms (ISDH) poster presentation, the author features a traditional board game as well as a reflection hologram to illustrate conventional and evolving Three-Dimensional representations and technology for education. Using elements from the American children's toy Operation® (Hasbro, 2005) as well as a reflection hologram of a human brain (Ko, 1998), this poster design highlights the pedagogical effects of 3-D images, games and systems on learning science. As teaching agents, holograms can be considered substitutes for real objects, (human beings, organs, and animated characters) as well as agents (pedagogical, avatars, reflective) in various learning environments using many systems (direct, emergent, augmented reality) and electronic tools (cellphones, computers, tablets, television). In order to understand the particular importance of utilizing holography in school, clinical and public settings, the author identifies advantages and benefits of using 3-D images and technology as instructional tools.

Walker, Robin A.

2013-02-01

187

Extending SATPLAN to Multiple Agents  

NASA Astrophysics Data System (ADS)

Multi-agent planning is a core issue in the multi-agent systems field. In this work we focus on the coordination of multiple agents in a setting where agents are able to achieve individual goals that may be either independent, or necessary for the achievement of a global common goal. The agents are able to generate individual plans in order to achieve their own goals, but, as they share the same environment, they need to find a coordinated course of action that avoids harmful (or negative) interactions, and benefits from positive interactions, whenever this is possible. Moreover, agents are interested in finding plans with optimal length where preference is given to the length of the joint plan. We formalize these problems in a more general way with respect to previous works and present a coordination algorithm which provides the optimal solution in the case of two agents. In this algorithm, agents use ?-SATPLAN as the underlying planner for generating individual and joint consistent plans. This planner is an extension of the well known classical planner SATPLAN, aiming to deal with negative and positive interactions and, therefore, with multi-agent planning problem. Finally we present the experimental results using the multi-agent planning problems from the domains proposed and used in classical planning, which demonstrate the effectiveness of ?-SATPLAN and the coordination algorithm.

Dimopoulos, Yannis; Hashmi, Muhammad Adnan; Moraitis, Pavlos

188

46 CFR Sec. 2 - General Agents' authority.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false General Agents' authority. Sec. 2 Section 2...AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Sec. 2 General Agents' authority. The General Agents...

2010-10-01

189

46 CFR Sec. 2 - General Agents' authority.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false General Agents' authority. Sec. 2 Section 2...AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Sec. 2 General Agents' authority. The General Agents...

2011-10-01

190

13 CFR 120.951 - Selling agent.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 false Selling agent. 120.951 Section...BUSINESS LOANS Development Company Loan Program (504) Debenture...Service Agents § 120.951 Selling agent. The CDC, with SBA approval, shall appoint a Selling Agent to select...

2010-01-01

191

13 CFR 120.951 - Selling agent.  

Code of Federal Regulations, 2011 CFR

... 2011-01-01 false Selling agent. 120.951 Section...BUSINESS LOANS Development Company Loan Program (504) Debenture...Service Agents § 120.951 Selling agent. The CDC, with SBA approval, shall appoint a Selling Agent to select...

2011-01-01

192

Surface preparation and coupling in plastic scintillator dosimetry  

SciTech Connect

One way to improve the performance of scintillation dosimeters is to increase the light-collection efficiency at the coupling interfaces of the detector system. We performed a detailed study of surface preparation of scintillating fibers and their coupling with clear optical fibers to minimize light loss and increase the amount of light collected. We analyzed fiber-surface polishing with aluminum oxide sheets, coating fibers with magnesium oxide, and the use of eight different coupling agents (air, three optical gels, an optical curing agent, ultraviolet light, cyanoacrylate glue, and acetone). We prepared 10 scintillating fiber and clear optical fiber light guide samples to test different coupling methods. To test the coupling, we first cut both the scintillating fiber and the clear optical fiber. Then, we cleaned and polished both ends of both fibers. Finally, we coupled the scintillating fiber with the clear optical fiber in either a polyethylene jacket or a V-grooved support depending on the coupling agent used. To produce more light, we used an ultraviolet lamp to stimulate scintillation. A typical series of similar couplings showed a standard deviation in light-collection efficiency of 10%. This can be explained by differences in the surface preparation quality and alignment of the scintillating fiber with the clear optical fiber. Absence of surface polishing reduced the light collection by approximately 40%, and application of magnesium oxide on the proximal end of the scintillating fiber increased the amount of light collected from the optical fiber by approximately 39%. Of the coupling agents, we obtained the best results using one of the optical gels. Because a large amount of the light produced inside a scintillator is usually lost, better light-collection efficiency will result in improved sensitivity.

Ayotte, Guylaine; Archambault, Louis; Gingras, Luc; Lacroix, Frederic; Beddar, A. Sam; Beaulieu, Luc [Departement de physique, de genie physique et d'optique, Universite Laval, Quebec City, Quebec, G1K7P4 (Canada) and Departement de Radio-Oncologie, Hotel Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, G1R2J6 (Canada); Departement de physique, de genie physique et d'optique, Universite Laval, Quebec City, Quebec, G1K7P4 (Canada) and Department de Radio-Oncologie, Hotel Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, G1R2J6 (Canada) and Department of Radiation Physics, Division of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Department de physique, de genie physique et d'optique, Universite Laval, Quebec City, Quebec, G1K7P4 (Canada) and Department de Radio-Oncologie, Hotel Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, G1R2J6 (Canada); Department of Radiation Physics, Division of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 (United States); Department de physique, de genie physique et d'optique, Universite Laval, Quebec City, Quebec, G1K7P4 (Canada) and Department de Radio-Oncologie, Hotel Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, G1R2J6 (Canada)

2006-09-15

193

Surface preparation and coupling in plastic scintillator dosimetry.  

PubMed

One way to improve the performance of scintillation dosimeters is to increase the light-collection efficiency at the coupling interfaces of the detector system. We performed a detailed study of surface preparation of scintillating fibers and their coupling with clear optical fibers to minimize light loss and increase the amount of light collected. We analyzed fiber-surface polishing with aluminum oxide sheets, coating fibers with magnesium oxide, and the use of eight different coupling agents (air, three optical gels, an optical curing agent, ultraviolet light, cyanoacrylate glue, and acetone). We prepared 10 scintillating fiber and clear optical fiber light guide samples to test different coupling methods. To test the coupling, we first cut both the scintillating fiber and the clear optical fiber. Then, we cleaned and polished both ends of both fibers. Finally, we coupled the scintillating fiber with the clear optical fiber in either a polyethylene jacket or a V-grooved support depending on the coupling agent used. To produce more light, we used an ultraviolet lamp to stimulate scintillation. A typical series of similar couplings showed a standard deviation in light-collection efficiency of 10%. This can be explained by differences in the surface preparation quality and alignment of the scintillating fiber with the clear optical fiber. Absence of surface polishing reduced the light collection by approximately 40%, and application of magnesium oxide on the proximal end of the scintillating fiber increased the amount of light collected from the optical fiber by approximately 39%. Of the coupling agents, we obtained the best results using one of the optical gels. Because a large amount of the light produced inside a scintillator is usually lost, better light-collection efficiency will result in improved sensitivity. PMID:17022248

Ayotte, Guylaine; Archambault, Louis; Gingras, Luc; Lacroix, Frédéric; Beddar, A Sam; Beaulieu, Luc

2006-09-01

194

Newer antihypertensive agents.  

PubMed

Three recent additions to the list of antihypertensive agents have been approved for use as monotherapy or in combination with other drugs. Betaxolol hydrochloride (Kerlone) maintains its effect for 24 hours, making it a true once-a-day beta blocker. Penbutolol sulfate (Levatol) is as effective as other beta blockers and diuretics. Doxazosin mesylate (Cardura), a selective alpha 1 blocker, also allows once-a-day dosing and has produced favorable changes in lipid profiles. Two new drug delivery systems, one for verapamil hydrochloride (Verelan) and one for extended-release nifedipine (Procardia XL), allow less frequent dosing and may offer other advantages, such as greater compliance and a more tolerable side-effect profile. PMID:2008405

Rey, A M; Grauer, K; Gums, J G

1991-04-01

195

Pharmacological agents for NASH.  

PubMed

NASH is a common liver disease that increases liver-related mortality and reduces survival. The need for optimal management of NASH is therefore a priority for today's practicing hepatologist. The rationale for specific pharmacological therapy for NASH is based on the potential for disease progression and the difficulties that many patients have successfully implementing, in the long term, diet and lifestyle changes. Even in those that succeed, limited evidence exists that severe liver injury in patients with NASH can be reversed by diet and lifestyle measures alone. This Review provides a personal and critical assessment of the histological efficacy and safety of agents tested in randomized trials in patients with NASH. PMID:24126564

Ratziu, Vlad

2013-11-01

196

Collaborating Fuzzy Reinforcement Learning Agents  

NASA Technical Reports Server (NTRS)

Earlier, we introduced GARIC-Q, a new method for doing incremental Dynamic Programming using a society of intelligent agents which are controlled at the top level by Fuzzy Relearning and at the local level, each agent learns and operates based on ANTARCTIC, a technique for fuzzy reinforcement learning. In this paper, we show that it is possible for these agents to compete in order to affect the selected control policy but at the same time, they can collaborate while investigating the state space. In this model, the evaluator or the critic learns by observing all the agents behaviors but the control policy changes only based on the behavior of the winning agent also known as the super agent.

Berenji, Hamid R.

1997-01-01

197

Agent-based enterprise integration  

SciTech Connect

The authors are developing and deploying software agents in an enterprise information architecture such that the agents manage enterprise resources and facilitate user interaction with these resources. Their enterprise agents are built on top of a robust software architecture for data exchange and tool integration across heterogeneous hardware and software. The resulting distributed multi-agent system serves as a method of enhancing enterprises in the following ways: providing users with knowledge about enterprise resources and applications; accessing the dynamically changing enterprise; intelligently locating enterprise applications and services; and improving search capabilities for applications and data. Furthermore, agents can access non-agents (i.e., databases and tools) through the enterprise framework. The ultimate target of their effort is the user; they are attempting to increase user productivity in the enterprise. This paper describes their design and early implementation and discusses their planned future work.

N. M. Berry; C. M. Pancerella

1999-05-01

198

Agent-based enterprise integration  

SciTech Connect

The authors are developing and deploying software agents in an enterprise information architecture such that the agents manage enterprise resources and facilitate user interaction with these resources. The enterprise agents are built on top of a robust software architecture for data exchange and tool integration across heterogeneous hardware and software. The resulting distributed multi-agent system serves as a method of enhancing enterprises in the following ways: providing users with knowledge about enterprise resources and applications; accessing the dynamically changing enterprise; locating enterprise applications and services; and improving search capabilities for applications and data. Furthermore, agents can access non-agents (i.e., databases and tools) through the enterprise framework. The ultimate target of the effort is the user; they are attempting to increase user productivity in the enterprise. This paper describes their design and early implementation and discusses the planned future work.

N. M. Berry; C. M. Pancerella

1998-12-01

199

Applet: Coupled Oscillators  

NSDL National Science Digital Library

This website from Dr. Wolfgang Bauer at the University of Michigan contains a java applet which allows the user to change certain parameters while observing simulated coupled oscillators. In the process of coupled oscillations, energy is transferred between the individual oscillators. This is how waves propagate. Here you can study this with the most simple example of two coupled spring oscillators.

Bauer, W. (Wolfgang), 1959-

2011-03-04

200

Thermally Coupled Distillation  

Microsoft Academic Search

This paper presents a brief overview in the design of mixed thermally coupled-heat integrated distillation sequences. The approach considers from conventional columns (each distillation column with a condenser and a reboiler) to fully thermally coupled systems (only one reboiler and one condenser in the entire system). The advantages and disadvantages of thermally coupled distillation in comparison with conventional columns are

José A. Caballero

2009-01-01

201

Counseling Mentally Retarded Couples.  

ERIC Educational Resources Information Center

This paper presents an experimental group model developed for counseling mentally retarded couples. The selection of the group counseling format is explained, group composition and eligibility requirements are described, and initial assessment of individuals and couples is presented. Preliminary sessions, geared toward orienting the couple to the…

Spragg, Paul A.; Miller, Cheryl

202

Extrospection: Agents Reasoning About the Environment  

Microsoft Academic Search

Current practices for agent-infrastructure interaction en- force agent designers to hard code the name and the use of the infrastructure components in the agent. Therefore, agents can only function within an environment which is a priori known to the agent designer. Even in these en- vironments, agents are not robust against the modification or failure of the infrastructures that may

Daghan L. Acay; Philippe Pasquier; Liz Sonenberg

203

Agent-based autonomous Examination Systems  

Microsoft Academic Search

Online computerized examination systems is developed using software agent technology. Multi-agent system containing main agent, mobile agent and stationery agent is developed to support the functionality of examination systems in Aglet environment. All these agents in the system communicate with each other to process the operations requested by the user. Authentication of the examinee for valid user name and password

R. D. Gawali; B. B. Meshram

2009-01-01

204

Switching biologic agents for uveitis  

Microsoft Academic Search

PurposeTo observe whether switching between biological agents helps to gain or maintain uveitis remission in cases with sight-threatening refractory uveitis.MethodsWe reviewed the case notes of seven patients with refractory uveitis, who had switched between biological agents. The switch between biological agents (infliximab or adalimumab) was for gaining control of systemic symptoms, uveitis, or for the ease of administration.ResultsThere were three

N Dhingra; J Morgan; A D Dick

2009-01-01

205

Communicative Actions for Artificial Agents  

Microsoft Academic Search

Abstract This paper considers,the semantics,of the agent com- munication,language,KQML. By using,this language for communication, agents will be able to request and provide services. Indeed, numerous projects have shown,how the language,can profitably,support,in- teroperation among distributed agents. However, he- fore becoming a widely-accepted standard, it would be worthwhile to examine the language in detail, espe-

Philip R. Cohen; Hector J. Levesque

1995-01-01

206

New agents for prostate cancer.  

PubMed

The therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC) has been revolutionized by the arrival of multiple novel agents in the past 2 years. Immunotherapy in the form of sipuleucel-T, androgen axis inhibitors, including abiraterone acetate and enzalutamide, a chemotherapeutic agent, cabazitaxel, and a radiopharmaceutical, radium-223, have all yielded incremental extensions of survival and have been recently approved. A number of other agents appear promising in early studies, suggesting that the armamentarium against castrate-resistant prostate cancer is likely to continue to expand. Emerging androgen pathway inhibitors include androgen synthesis inhibitors (TAK700), androgen receptor inhibitors (ARN-509, ODM-201), AR DNA binding domain inhibitors (EPI-001), selective AR downregulators or SARDs (AZD-3514), and agents that inhibit both androgen synthesis and receptor binding (TOK-001/galeterone). Promising immunotherapeutic agents include poxvirus vaccines and CTLA-4 inhibitor (ipilimumab). Biologic agents targeting the molecular drivers of disease are also being investigated as single agents, including cabozantinib (Met and VEGFR2 inhibitor) and tasquinimod (angiogenesis and immune modulatory agent). Despite the disappointing results seen from studies evaluating docetaxel in combination with other agents, including GVAX, anti-angiogentic agents (bevacizumab, aflibercept, lenalinomide), a SRC kinase inhibitor (dasatinib), endothelin receptor antagonists (atrasentan, zibotentan), and high-dose calcitriol (DN-101), the results from the trial evaluating docetaxel in combination with the clusterin antagonist, custirsen, are eagerly awaited. New therapeutic hurdles consist of discovering new targets, understanding resistance mechanisms, the optimal sequencing and combinations of available agents, as well as biomarkers predictive for benefit. Novel agents targeting bone metastases are being developed following the success of zoledronic acid and denosumab. Finally, all of these modalities do not appear curative, suggesting that clinical trial enrollment and a better understanding of biology remain of paramount importance. PMID:24658665

Agarwal, N; Di Lorenzo, G; Sonpavde, G; Bellmunt, J

2014-09-01

207

Cultural Differentiation of Negotiating Agents  

Microsoft Academic Search

Negotiations proceed differently across cultures. For realistic modeling of agents in multicultural negotiations, the agents\\u000a must display culturally differentiated behavior. This paper presents an agent-based simulation model that tackles these challenges,\\u000a based on Hofstede’s model of national cultures. The context is a trade network for goods with a hidden quality attribute.\\u000a The negotiation model is based on the ABMP negotiation

Gert Jan Hofstede; Catholijn M. Jonker; Tim Verwaart

2010-01-01

208

Knowledge Agents on the Web  

Microsoft Academic Search

\\u000a This paper introduces and evaluates a new paradigm, called Knowledge Agents, that incorporates agent technology into the process\\u000a of domainspecific Web search. An agent is situated between the user and a search engine. It specializes in a specific domain\\u000a by extracting characteristic information from search results. Domains are thus user-defined and can be of any granularity\\u000a and specialty. This information

Yariv Aridor; David Carmel; Ronny Lempel; Aya Soffer; Yoëlle S. Maarek

2000-01-01

209

Agent based spin model for financial markets on regular lattices and complex networks  

NASA Astrophysics Data System (ADS)

We study an agent based microscopic model for price formation in financial markets on various topologies motivated by the dynamics of agents. The model consists of interacting agents (spins) with localand global couplings. The local interaction denotes the tendency of agents to make the same decision with their interacting partners. On the other hand, the global coupling to the self-generating field represents the process which maximizes the profit of each agent. In order to incorporate more realistic situations, we also introduce an external field which changes in time. This time-varying external field represents any internal or external interference in the dynamics of the market. For the proper choice of model parameters, the competition between the interactions causes an intermittency dynamics and we find that the distribution of logarithmic return of price follows a power-law.

Kim, Hong-Joo; Yook, Soon-Hyung; Kim, Yup

2008-03-01

210

Agent Tcl: A flexible and secure mobile-agent system  

Microsoft Academic Search

A mobile agent is an autonomous program that can migrate under its own control from machine to machine in a heterogeneous network. In other words, the program can suspend its execution at an arbitrary point, transport itself to another machine, and then resume execution from the point of suspension. Mobile agents have the potential to provide a single, general framework

Robert S. Gray

1997-01-01

211

Software Agents and Multiagent Systems Agent Oriented Software Engineering  

E-print Network

, and is meant only for students' personal use. Any use different from the students' personal use is prohibited methodologies 3 Notation techniques 4 MAS infrastructures 5 Our research experience: WEST2EAST SIIT Master. Challenges and Research Directions in Agent-Oriented Software Engineering. Journal of Autonomous Agents

Mascardi, Viviana

212

Olga -a conversational agent with gestures Multimodal Agent Interfaces  

E-print Network

to delegate some tasks to an interface agent. Tasks can be established by, for example, explicit user of predictability, control and comprehension for the user (Schneiderman, 1997). Natural language, especially speech, offers a natural mechanism by which users can explicitly provide an agent with tasks. A speech interface

Beskow, Jonas

213

Coupled unstable resonators  

NASA Astrophysics Data System (ADS)

Coupling of unstable resonators in circulant arrays is considered, in which the array is invariant with respect to the interchange of any pair of resonators. A proof-of-concept experiment performed with six series coupled CO(2) lasers with confocal unstable resonators is reported. Adjoint coupling was used with two symmetrically placed coupling apertures in each resonator output. The results of measurements of the locking range, supermode content, and beam quality for standing wave and ring resonator arrays are presented and interpreted using simplified models. It is pointed out that adjoint coupled unstable resonators provide a modular scaling configuration with modest phase-locking length control requirements.

Palma, G. E.; Benda, J. A.; Townsend, S. S.; Cunningham, P. R.; Forgham, J.

1990-06-01

214

TACtic- A Multi Behavioral Agent for Trading Agent Competition  

NASA Astrophysics Data System (ADS)

Software agents are increasingly being used to represent humans in online auctions. Such agents have the advantages of being able to systematically monitor a wide variety of auctions and then make rapid decisions about what bids to place in what auctions. They can do this continuously and repetitively without losing concentration. To provide a means of evaluating and comparing (benchmarking) research methods in this area the trading agent competition (TAC) was established. This paper describes the design, of TACtic. Our agent uses multi behavioral techniques at the heart of its decision making to make bidding decisions in the face of uncertainty, to make predictions about the likely outcomes of auctions, and to alter the agent's bidding strategy in response to the prevailing market conditions.

Khosravi, Hassan; Shiri, Mohammad E.; Khosravi, Hamid; Iranmanesh, Ehsan; Davoodi, Alireza

215

A model of coupled maps with Pareto behavior  

E-print Network

A deterministic system of coupled maps is proposed as a model for economic activity among interacting agents. The values of the maps represent the wealth of the agents. The dynamics of the system is controlled by two parameters. One parameter expresses the growth capacity of the agents and the other describes the local environmental pressure. For some values of the parameters, the system exhibits nontrivial collective behavior, characterized by macroscopic periodic oscillations of the average wealth of the system, emerging out of local chaos. The probability distribution of wealth in the asymptotic regime shows a power law behavior for some ranges of parameters.

J. R. Sanchez; J. Gonzalez-Estevez; R. Lopez-Ruiz; M. G. Cosenza

2007-01-09

216

Agent Model Development for Assessing Climate-Induced Geopolitical Instability.  

SciTech Connect

We present the initial stages of development of new agent-based computational methods to generate and test hypotheses about linkages between environmental change and international instability. This report summarizes the first year's effort of an originally proposed three-year Laboratory Directed Research and Development (LDRD) project. The preliminary work focused on a set of simple agent-based models and benefited from lessons learned in previous related projects and case studies of human response to climate change and environmental scarcity. Our approach was to define a qualitative model using extremely simple cellular agent models akin to Lovelock's Daisyworld and Schelling's segregation model. Such models do not require significant computing resources, and users can modify behavior rules to gain insights. One of the difficulties in agent-based modeling is finding the right balance between model simplicity and real-world representation. Our approach was to keep agent behaviors as simple as possible during the development stage (described herein) and to ground them with a realistic geospatial Earth system model in subsequent years. This work is directed toward incorporating projected climate data--including various C02 scenarios from the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report--and ultimately toward coupling a useful agent-based model to a general circulation model.3

Boslough, Mark B.; Backus, George A.

2005-12-01

217

Phytonutrients as therapeutic agents.  

PubMed

Nutrients present in various foods plays an important role in maintaining the normal functions of the human body. The major nutrients present in foods include carbohydrates, proteins, lipids, vitamins, and minerals. Besides these, there are some bioactive food components known as "phytonutrients" that play an important role in human health. They have tremendous impact on the health care system and may provide medical health benefits including the prevention and/or treatment of disease and various physiological disorders. Phytonutrients play a positive role by maintaining and modulating immune function to prevent specific diseases. Being natural products, they hold a great promise in clinical therapy as they possess no side effects that are usually associated with chemotherapy or radiotherapy. They are also comparatively cheap and thus significantly reduce health care cost. Phytonutrients are the plant nutrients with specific biological activities that support human health. Some of the important bioactive phytonutrients include polyphenols, terpenoids, resveratrol, flavonoids, isoflavonoids, carotenoids, limonoids, glucosinolates, phytoestrogens, phytosterols, anthocyanins, ?-3 fatty acids, and probiotics. They play specific pharmacological effects in human health such as anti-microbial, anti-oxidants, anti-inflammatory, antiallergic, anti-spasmodic, anti-cancer, anti-aging, hepatoprotective, hypolipidemic, neuroprotective, hypotensive, diabetes, osteoporosis, CNS stimulant, analgesic, protection from UVB-induced carcinogenesis, immuno-modulator, and carminative. This mini-review attempts to summarize the major important types of phytonutrients and their role in promoting human health and as therapeutic agents along with the current market trend and commercialization. PMID:25051278

Gupta, Charu; Prakash, Dhan

2014-09-01

218

Plasmids encoding therapeutic agents  

DOEpatents

Plasmids encoding anti-HIV and anti-anthrax therapeutic agents are disclosed. Plasmid pWKK-500 encodes a fusion protein containing DP178 as a targeting moiety, the ricin A chain, an HIV protease cleavable linker, and a truncated ricin B chain. N-terminal extensions of the fusion protein include the maltose binding protein and a Factor Xa protease site. C-terminal extensions include a hydrophobic linker, an L domain motif peptide, a KDEL ER retention signal, another Factor Xa protease site, an out-of-frame buforin II coding sequence, the lacZ.alpha. peptide, and a polyhistidine tag. More than twenty derivatives of plasmid pWKK-500 are described. Plasmids pWKK-700 and pWKK-800 are similar to pWKK-500 wherein the DP178-encoding sequence is substituted by RANTES- and SDF-1-encoding sequences, respectively. Plasmid pWKK-900 is similar to pWKK-500 wherein the HIV protease cleavable linker is substituted by a lethal factor (LF) peptide-cleavable linker.

Keener, William K. (Idaho Falls, ID)

2007-08-07

219

Programming Satan's Agents Volker Roth  

E-print Network

Programming Satan's Agents Volker Roth Fraunhofer Institute for Computer Graphics Dept. Security Satan's Computer" [1], which was published in 1995. A version of its abstract serves us as introduction from programming Satan's agents [computer] may be helpful in tackling the more common problem

Roth, Volker

220

Agent-Based Literacy Theory  

ERIC Educational Resources Information Center

The purpose of this theoretical essay is to explore the limits of traditional conceptualizations of reader and text and to propose a more general theory based on the concept of a literacy agent. The proposed theoretical perspective subsumes concepts from traditional theory and aims to account for literacy online. The agent-based literacy theory…

McEneaney, John E.

2006-01-01

221

Gelled Anti-icing Agents  

NASA Technical Reports Server (NTRS)

Pectin added to antifreeze/water mixture. Formulations include water with dimethyl sulfoxide (DMSO) as deicer and pectin as gel former. Without gelling agent, deicer runs off vertical surfaces. Without pectin solution will completely evaporate in far less time. Agents developed have wide potential for ice prevention on runways, highways, bridges and sidewalks.

Markles, O. F.; Sperber, H. H.

1983-01-01

222

Hypothesis Testing for Complex Agents  

Microsoft Academic Search

As agents approach animal-like complexity, evaluat- ing them becomes as difficult as evaluating animals. This paper describes the application of techniques for characterizing animal behavior to the evaluation of com- plex agents. We describe the conditions that lead to the behavioral variability that requires experimental meth- ods. We then review the state of the art in psychologi- cal experimental design

Joanna Bryson; Will Lowey; Lynn Andrea Stein

2000-01-01

223

Artificial agents learning human fairness  

Microsoft Academic Search

Recent advances in technology allow multi-agent systems to be de- ployed in cooperation with or as a service for humans. Typically, those systems are designed assuming individually rational agents, according to the principles of classical game theory. However, re- search in the field of behavioral economics has shown that humans are not purely self-interested: they strongly care about fairness. Therefore,

Steven De Jong; Karl Tuyls; Katja Verbeeck

2008-01-01

224

Implementing Lego Agents Using Jason  

E-print Network

Since many of the currently available multi-agent frameworks are generally mostly intended for research, it can be difficult to built multi-agent systems using physical robots. In this report I describe a way to combine the multi-agent framework Jason, an extended version of the agent-oriented programming language AgentSpeak, with Lego robots to address this problem. By extending parts of the Jason reasoning cycle I show how Lego robots are able to complete tasks such as following lines on a floor and communicating to be able to avoid obstacles with minimal amount of coding. The final implementation is a functional extension that is able to built multi-agent systems using Lego agents, however there are some issues that have not been addressed. If the agents are highly dependent on percepts from their sensors, they are required to move quite slowly, because there currently is a high delay in the reasoning cycle, when it is combined with a robot. Overall the system is quite robust and can be used to make simple...

Jensen, Andreas Schmidt

2010-01-01

225

Itinerant agents for mobile computing  

Microsoft Academic Search

Describes a framework for itinerant agents that can be used to implement secure, remote applications in large, public networks such as the Internet or the IBM Global Network. Itinerant agents are programs, dispatched from a source computer, that roam among a set of networked servers until they accomplish their task. This is an extension to the client\\/server model in which

David Chess; Benjamin Grosof; Colin Harrison; David Levine; Colin Parris; Gene Tsudik

1995-01-01

226

Pathogenic agents in freshwater resources  

Microsoft Academic Search

Numerous pathogenic agents have been found in freshwaters used as sources for water supplies, recreational bathing and irrigation. These agents include bacterial pathogens, enteric viruses, several protozoans and parasitic worms more common to tropical waters. Although infected humans are a major source of pathogens, farm animals (cattle, sheep, pigs), animal pets (dogs, cats) and wildlife serve as significant reservoirs and

Edwin E. Geldreich

1996-01-01

227

Ethical issues confronting travel agents  

Microsoft Academic Search

This article provides an overview of current and prospective ethical issues facing commercial (as opposed to leisure) travel agents. Industry wide ethical issues include conflicting pressures from suppliers and clients, competency requirements for agents and misleading advertising and sales claims (“vaporware” in industry jargon). Issues with travel suppliers include calculation and payment of commissions, fare loopholes, frequent flyer plans and

Thomas W. Dunfee; Bruce M. Black

1996-01-01

228

Cooperating Air Traffic Control Agents  

Microsoft Academic Search

The key aim of cooperating air traffic control agents (CAT CA) was to comparatively analyze and evaluate the success of a multiagent system (MAS) and a single agent system (SAS) at addressing a given set of goals in a problem domain amenable to the utilization of either a MAS or SAS. The problem domain selected was air traffic control (AT

Geoff Nitschke

2001-01-01

229

Intelligent agents for intrusion detection  

Microsoft Academic Search

The paper focuses on intrusion detection and countermeasures with respect to widely-used operating systems and networks. The design and architecture of an intrusion detection system built from distributed agents is proposed to implement an intelligent system on which data mining can be performed to provide global, temporal views of an entire networked system. A starting point for agent intelligence in

Guy G. Helmer; Johnny S. K. Wong; Vasant Honavar; Les Miller

1998-01-01

230

SOCIALLY INTELLIGENT AGENTS Creating Relationships  

E-print Network

Relationship: An Agent Architecture for Voluntary Mutual Control 29 Alan H. Bond 4 Developing Agents Who can Edmund Chattoe 14 Robotic Playmates: Analysing Interactive Competencies of Children with Autism Playing Théberge-Turmel 16 Affective Social Quest: Emotion Recognition Therapy for Autistic Children 133 Katharine

Cañamero, Lola

231

Humean agent-neutral reasons?  

Microsoft Academic Search

In his recent book Slaves of the Passions, Mark Schroeder defends a Humean account of practical reasons (hypotheticalism). He argues that it is compatible with ‘genuinely agent-neutral reasons’. These are reasons that any agent whatsoever has. According to Schroeder, they may well include moral reasons. Furthermore, he proposes a novel account of a reason's weight, which is supposed to vindicate

Daan Evers

2009-01-01

232

Team Description Paper Agent competition  

E-print Network

Traichioiu and Arnoud Visser Universiteit van Amsterdam, Science Park 904, 1098 XH Amsterdam, NL http approach State Description The state space for the task of fire fighting in RoboCup Rescue is limited) can in turn be divided into fire, police and ambulance agents. The center agents func- tion

Visser, Arnoud

233

Proactive Communications in Agent Teamwork  

Microsoft Academic Search

The capabilities for agents in a team to anticipate information- needs of teammates and proactively ofier relevant information are highly desirable. However, such behaviors have not been fully prescribed by ex- isting agent theories. To establish a theory about proactive information exchanges, we flrst introduces the concept of \\\\information-needs\\

John Yen; Xiaocong Fan; Richard A. Volz

2003-01-01

234

Transdermal delivery of therapeutic agent  

NASA Technical Reports Server (NTRS)

A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.

Kwiatkowski, Krzysztof C. (Inventor); Hayes, Ryan T. (Inventor); Magnuson, James W. (Inventor); Giletto, Anthony (Inventor)

2008-01-01

235

Separation and analysis of lanthanides by isotachophoresis coupled with inductively coupled plasma mass spectrometry.  

PubMed

This study is a large project initiated by the French Nuclear Agency, and concerns the development of a new electrolyte system for the separation of lanthanides by isotachophoresis. This new system is based on a leading electrolyte that incorporates 2-hydroxy-2-methylbutyric acid as complexing agent. The optimization of separation conditions (complexing agent concentration, pH, capillary dimensions, injection conditions, and current intensity) performed by experiments on a commercial capillary instrument with contactless conductivity detection, which allows to improve the separation of 13 lanthanides (La to Lu, except Pm and Ho). We have also directly coupled the isotachophoresis to an inductively coupled plasma mass spectrometer to visualize the mono-elementary elution bands and demonstrate the potentiality of the method for isotope ratio measurements. The application to a simulated solution representative of a fraction of fission products present in a MOX spent fuel is presented in this paper to demonstrate the possible application in future on nuclear fuel samples. PMID:22967598

Vio, Laurent; Crétier, Gérard; Chartier, Frédéric; Geertsen, Valérie; Gourgiotis, Alkiviadis; Isnard, Hélène; Rocca, Jean-Louis

2012-09-15

236

Game Couplings: Learning Dynamics and Applications Maria-Florina Balcan ninamf@cc.gatech.edu  

E-print Network

Game Couplings: Learning Dynamics and Applications Maria-Florina Balcan ninamf, Georgia Institute of Technology, Atlanta, GA 30332 Abstract Games encode complex strategic interactions involving numerous agents. Specific game properties, such as the existence of a potential function (Monderer

Shamma, Jeff S.

237

Three tooth kinematic coupling  

DOEpatents

A three tooth kinematic coupling based on having three theoretical line contacts formed by mating teeth rather than six theoretical point contacts. The geometry requires one coupling half to have curved teeth and the other coupling half to have flat teeth. Each coupling half has a relieved center portion which does not effect the kinematics, but in the limit as the face width approaches zero, three line contacts become six point contacts. As a result of having line contact, a three tooth coupling has greater load capacity and stiffness. The kinematic coupling has application for use in precision fixturing for tools or workpieces, and as a registration device for a work or tool changer or for optics in various products.

Hale, Layton C. (Livermore, CA)

2000-01-01

238

Pharmacologic review of thrombolytic agents.  

PubMed

Thrombolytic therapy has significantly reduced the morbidity and mortality that was once associated with acute myocardial infarction. Because of the substantial benefits associated with this therapy, investigation has intensified in search of the optimal agent or agents. Five agents are currently being investigated individually and in various combinations to determine which agent(s) will outperform the others in terms of reperfusion, patency, mortality reduction, and clinical events. Two of the agents, t-PA and scu-PA, are considered fibrin selective, whereas the other three, streptokinase, urokinase and APSAC are nonselective. Whether this distinction provides substantial benefit is still not known. All of the FDA-approved agents (streptokinase, t-PA, and APSAC) have demonstrated survival benefit and will continue to be administered in AMI patients. In addition, the 1990s begins a new era that includes broadened selection criteria for AMI patients as well as expanding cardiovascular indications for thrombolytic therapy. The challenge to nurses is to improve and implement nursing care practices at the same rapid pace set by the medical discipline. This includes astute assessment and observational skills necessary to prevent and detect potential complications associated with thrombolytic therapy. Rapidly changing medical techniques mandate ongoing nursing research, which is needed to determine the most effective interventions in reducing complications associated with thrombolytic therapy and in promoting positive adaptive behaviors in the AMI patient. Thrombolytic therapy is an intervention for the 1990s, and nursing care is essential in maintaining the beneficial effects of this dynamic therapy. PMID:2096866

Kline, E M

1990-12-01

239

Nuclear magnetic resonance contrast agents  

DOEpatents

A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC{sub 16}H{sub 14}N{sub 6}. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques. 10 figs.

Smith, P.H.; Brainard, J.R.; Jarvinen, G.D.; Ryan, R.R.

1997-12-30

240

Nuclear magnetic resonance contrast agents  

DOEpatents

A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC.sub.16 H.sub.14 N.sub.6. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques.

Smith, Paul H. (Los Alamos, NM); Brainard, James R. (Los Alamos, NM); Jarvinen, Gordon D. (Los Alamos, NM); Ryan, Robert R. (Los Alamos, NM)

1997-01-01

241

Symptom management for schizophrenic agents  

SciTech Connect

Behavior-based paradigms are a promising avenue towards creating full-blown integrated autonomous agents. However, until now they have had a major stumbling block: programmers can create robust, subtle, and expressive behaviors, but the agent`s overall behavior gradually falls apart as these behaviors are combined. For small numbers of behaviors, this disintegration can be managed by the programmer, but as more behaviors are combined their interactions become so complex that they become at least time-consuming and at worst impossible to manage.

Sengers, P. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

1996-12-31

242

Corrosion protection of aluminum by silane-based surface treatment  

NASA Astrophysics Data System (ADS)

The possibility of using silane coupling agents as replacements for chromate treatments was investigated for aluminum substrates. In order to understand the influence of deposition parameters on silane film formation, pure Al substrates were used to study the interaction between silane coupling agents and aluminum surfaces. The silane films formed on pure A1 substrates from aqueous solutions were characterized by ellipsometry, contact angle measurements, reflection absorption infrared spectroscopy, x-ray photoelectron spectroscopy, and Time-of Flight Secondary Ion Mass Spectrometry. The deposition parameters studied include solution concentration, solution dipping time and pH value of the applied solution. It appears that silane film formation involved a true equilibrium of hydrolysis and condensation in aqueous solution. It has been found that the silane film thickness obtained depends primarily on the solution concentration and is independent of the solution dipping time. The molecular orientation of the applied silane film is determined by the pH value of the applied silane solution and the isoelectic point of the metal substrates. The deposition window in terms of pH value for A1 substrates is between 4 and 7. The total surface energy of silane-coated A1 substrate decreases with film aging time, the decreased rate, however, is determined by the nature of silane coupling agents. Based on the results obtained above, a pretreatment, which involved two-step bis-(triethoxysilyl) ethane and gamma-aminopropyltriethoxysilane, was developed for Al substrates with commercial polyester and polyurethane paints. The results of salt spray testing, cyclic corrosion testing, and electrochemical impedance spectroscopy showed that this treatment provided the same level of corrosion performance as the treatment of phosphating plus a final chromate rinse. The likely reasons for excellent performance are discussed in terms of the physical and chemical characteristics of the treatment layers and their stability in the under-film corrosion environment. Salt spray test results showed that two-step BTSE/gamma-APS could provide the same or better corrosion protection than that offered by a standard chromate treatment. Polyester or polyurethane powder-painted Al panels, pretreated with this treatment, also displayed excellent corrosion performances in the salt spray test and filiform corrosion test. Thus, the advantage of this treatment is that is combines a temporary rust prevention and a permanent prepaint treatment into one simple approach. Electrochemical impedance spectroscopy was used to study the various pre-paint treatments under the polyester paint. It provides more detailed mechanistic information about corrosion processes than salt spray test and filiform corrosion test. However, combination of corrosion tests that involve different corrosion mechanisms may still be necessary to have a better understanding of corrosion behavior of a new treatment.

Song, Jun

243

Launch Commit Criteria Monitoring Agent  

NASA Technical Reports Server (NTRS)

The Spaceport Processing Systems Branch at NASA Kennedy Space Center has developed and deployed a software agent to monitor the Space Shuttle's ground processing telemetry stream. The application, the Launch Commit Criteria Monitoring Agent, increases situational awareness for system and hardware engineers during Shuttle launch countdown. The agent provides autonomous monitoring of the telemetry stream, automatically alerts system engineers when predefined criteria have been met, identifies limit warnings and violations of launch commit criteria, aids Shuttle engineers through troubleshooting procedures, and provides additional insight to verify appropriate troubleshooting of problems by contractors. The agent has successfully detected launch commit criteria warnings and violations on a simulated playback data stream. Efficiency and safety are improved through increased automation.

Semmel, Glenn S.; Davis, Steven R.; Leucht, Kurt W.; Rowe, Dan A.; Kelly, Andrew O.; Boeloeni, Ladislau

2005-01-01

244

Agent-based forward analysis  

SciTech Connect

We propose software agent-based "forward analysis" for efficient information retrieval in a network of sensing devices. In our approach, processing is pushed to the data at the edge of the network via intelligent software agents rather than pulling data to a central facility for processing. The agents are deployed with a specific query and perform varying levels of analysis of the data, communicating with each other and sending only relevant information back across the network. We demonstrate our concept in the context of face recognition using a wireless test bed comprised of PDA cell phones and laptops. We show that agent-based forward analysis can provide a significant increase in retrieval speed while decreasing bandwidth usage and information overload at the central facility. n

Kerekes, Ryan A [ORNL; Jiao, Yu [ORNL; Shankar, Mallikarjun [ORNL; Potok, Thomas E [ORNL; Lusk, Rick M [ORNL

2008-01-01

245

Dynamic Economy with Heterogeneous Agents  

E-print Network

. As in traditional, the production function G( H ; xHt; yHHt) is strictly increasing and concave. With regarding knowledge spillovers, just as in Eaton and Eckstein [31], Lucas [67], in the proceeding of human capital accumulation, as a result of the di erence 11...)2 @Hh3 @yHh2 = ( U LH2 H 0H2 + U LH3 ylh3 (H"H3)2 @H"H3 @yHh2 ) (2.31) Here U denotes the utility when high ability agent pretends to be low ability agent. The high ability agent?s physical capital xHt which is used for human capital...

Peng, Yulei

2013-08-06

246

Classification by pairwise coupling  

Microsoft Academic Search

We discuss a strategy for polychotomous classification that involves coupling the estimating class probabilities for each pair of classes, and estimates together. The coupling model is similar to the Bradley-Terry method for paired comparisons. We study the nature of the class probability estimates that arise, and examine the performance of the procedure in real and simulated data sets. Classifiers used

Trevor Hastie; Robert Tibshirani

1998-01-01

247

Coupled Oscillation Simulation  

NSDL National Science Digital Library

This applet simulates a harmonic coupled line of masses moving in one dimension. The number and size of loads, damping, speed of the simulation and stiffness of the springs are adjustable, and the phases and magnitudes of the normal modes are shown. The applet also simulates elastic collisions and weak couplings and demonstrates lissajous figures. Source code is included.

Falstad, Paul

2004-07-13

248

Emotionally Focused Couple Therapy  

Microsoft Academic Search

Working with couples who are both survivors of emotional abuse and are currently in an emotionally abusive relationship can be particularly challenging for the clinician. This article focuses on Emotionally Focused Couple Therapy as a recommended practice approach for clients who are caught in emotionally abusive patterns with one another. The article reviews relevant literature on this approach and illustrates

Nancy L. Beckerman; Michele Sarracco

2002-01-01

249

31 CFR 10.4 - Eligibility for enrollment as enrolled agent or enrolled retirement plan agent.  

Code of Federal Regulations, 2011 CFR

... false Eligibility for enrollment as enrolled agent or enrolled retirement plan agent. 10.4 Section 10.4 Money and Finance...10.4 Eligibility for enrollment as enrolled agent or enrolled retirement plan agent. (a)...

2011-07-01

250

76 FR 2617 - User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents; Hearing Cancellation  

Federal Register 2010, 2011, 2012, 2013

...RIN 1545-BJ65 User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents; Hearing Cancellation AGENCY: Internal Revenue...relating to the imposition of user fees for enrolled agents and enrolled retirement plan agents....

2011-01-14

251

75 FR 76940 - User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents  

Federal Register 2010, 2011, 2012, 2013

...RIN 1545-BJ65 User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents AGENCY: Internal Revenue Service (IRS), Treasury...relating to the imposition of user fees for enrolled agents and enrolled retirement plan agents. The...

2010-12-10

252

Agent Applications in Rail Transportation  

Microsoft Academic Search

This paper discusses the applications of agent-oriented techniques for modelling of the behaviour of a railway transportation system which consists of numerous interacting parties with different objectives, interests, autonomy, constraints, responsibilities and decision-making capabilities. The agent model covers both business and operational aspects of the system and it enables possible connections to other modes of transportation and\\/or external monitoring bodies.

T. K. Ho; L. Ferreira

253

Everything is alive agent architecture  

Microsoft Academic Search

Scalable agent systems must be able to evolve and adapt to a changing environment. Everything is Alive (EiA) is a compositional middleware architecture useful in building scalable, adaptive systems, including agent systems. EiA uses plugin capabilities compatible with the Eclipse.org framework, but these capabilities are extended using the E2 platform to allow plugins to be removed or replaced. Capabilities, described

Joseph Robertson; Craig Thompson

2005-01-01

254

Nonsteroid immunosuppressive agents and bone  

Microsoft Academic Search

The immunosuppressive agents introduced to enhance the action of glucocorticoids and to prevent organ rejection had a dramatic\\u000a impact on reducing the incidence of organ rejection, enhancing donor organ, and hence patient survival following transplantation.\\u000a However, these agents, cyclosporine and tacrolimus, termed calcineurin inhibitors (CIs) also have side effects, including the promotion of rapid and severe bone loss in vivo

Solomon Epstein; Angela M. Inzerillo

2004-01-01

255

Walverine: a Walrasian trading agent  

Microsoft Academic Search

TAC-02 was the third in a series of Trading Agent Competition events fostering research in automating trading strategies by showcasing alternate approaches in an open-invitation market game. TAC presents a challenging travel-shopping scenario where agents must satisfy client preferences for complementary and substitutable goods by interacting through a variety of market types. Michigan's entry, Walverine, attempts to bid optimally based

Shih-Fen Cheng; Evan Leung; Kevin M. Lochner; Kevin O'Malley; Daniel M. Reeves; L. Julian Schvartzman; Michael P. Wellman

2003-01-01

256

Exponentially modified QCD coupling  

SciTech Connect

We present a specific class of models for an infrared-finite analytic QCD coupling, such that at large spacelike energy scales the coupling differs from the perturbative one by less than any inverse power of the energy scale. This condition is motivated by the Institute for Theoretical and Experimental Physics operator product expansion philosophy. Allowed by the ambiguity in the analytization of the perturbative coupling, the proposed class of couplings has three parameters. In the intermediate energy region, the proposed coupling has low loop-level and renormalization scheme dependence. The present modification of perturbative QCD must be considered as a phenomenological attempt, with the aim of enlarging the applicability range of the theory of the strong interactions at low energies.

Cvetic, Gorazd [Department of Physics, Universidad Tecnica Federico Santa Maria, Valparaiso (Chile); Center of Subatomic Studies, UTFSM, Valparaiso (Chile); Valenzuela, Cristian [Department of Physics, Universidad Tecnica Federico Santa Maria, Valparaiso (Chile)

2008-04-01

257

The model coupling toolkit.  

SciTech Connect

The advent of coupled earth system models has raised an important question in parallel computing: What is the most effective method for coupling many parallel models to form a high-performance coupled modeling system? We present our solution to this problem--The Model Coupling Toolkit (MCT). We explain how our effort to construct the Next-Generation Coupler for NCAR Community Climate System Model motivated us to create this toolkit. We describe in detail the conceptual design of the MCT and explain its usage in constructing parallel coupled models. We present preliminary performance results for the toolkit's parallel data transfer facilities. Finally, we outline an agenda for future development of the MCT.

Larson, J. W.; Jacob, R. L.; Foster, I.; Guo, J.

2001-04-13

258

Ignorable Information in Multi-Agent Scenarios  

E-print Network

In some multi-agent scenarios, identifying observations that an agent can safely ignore reduces exponentially the size of the agent's strategy space and hence the time required to find a Nash equilibrium. We consider games ...

Milch, Brian

2008-05-12

259

7 CFR 58.722 - Emulsifying agents.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 false Emulsifying agents. 58.722 Section 58.722 Agriculture Regulations of the Department of Agriculture...1 Quality Specifications for Raw Material § 58.722 Emulsifying agents. Emulsifying agents...

2010-01-01

260

46 CFR Sec. 3 - General Agents' responsibilities.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false General Agents' responsibilities. Sec. 3 Section...AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Sec. 3 General Agents' responsibilities. In the...

2010-10-01

261

46 CFR Sec. 3 - General Agents' responsibilities.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false General Agents' responsibilities. Sec. 3 Section...AUTHORITY AND RESPONSIBILITY OF GENERAL AGENTS TO UNDERTAKE EMERGENCY REPAIRS IN FOREIGN PORTS Sec. 3 General Agents' responsibilities. In the...

2011-10-01

262

Partner switching promotes cooperation among myopic agents on a geographical plane  

NASA Astrophysics Data System (ADS)

We study the coupling dynamics between the evolution of cooperation and the evolution of partnership network on a geographical plane. While agents play networked prisoner’s dilemma games, they can dynamically adjust their partnerships based on local information about reputation. We incorporate geographical features into the process of the agent’s partner switching and investigate the corresponding effects. At each time step of the coevolution, a random agent can either update his strategy by imitation or adjust his partnership by switching from the lowest reputation partner to the highest reputation one among his neighbors. We differentiate two types of neighbors: geographical neighbors (i.e., the set of agents who are close to the focal agent in terms of geographical distance) and connectivity neighbors (i.e., the set of agents who are close to the focal agent in the partnership network in terms of geodesic distance). We find that switching to either geographical neighbors or connectivity neighbors enhances cooperation greatly in a wide parameter range. Cooperation can be favored in a much stricter condition when agents switch to connectivity neighbors more frequently. However, an increasing tendency of reconnecting to geographical neighbors shortens the geographical distance between a pair of partners on average. When agents consider the cost of geographical distance in adjusting the partnership, they are prone to reconnect to geographical neighbors.

Li, Yixiao; Min, Yong; Zhu, Xiaodong; Cao, Jie

2013-02-01

263

Intelligent agent for aircraft collision avoidance  

E-print Network

System Silicon Graphics Incorporated Soft Pilot/Flight Management System Interface TCP/IP Transmission Control Protocol /Internet Protocol TFC Agent TRAG UDP Traffic Agent Ground Course Tracking Agent User Datagram Protocol vn VFR VMF Visual... System Silicon Graphics Incorporated Soft Pilot/Flight Management System Interface TCP/IP Transmission Control Protocol /Internet Protocol TFC Agent TRAG UDP Traffic Agent Ground Course Tracking Agent User Datagram Protocol vn VFR VMF Visual...

Shandy, Surya Utama

2012-06-07

264

ADK: An Agent Development Kit Based on a Formal Design Model for Multi-Agent Systems  

E-print Network

agent is defined as an agent that has the ability to perceive and to respond to a changing environment a reactive agent an event-driven agent, and an event could be any environment change that may influence1 ADK: An Agent Development Kit Based on a Formal Design Model for Multi-Agent Systems Haiping Xu

Xu, Haiping

265

76 FR 21805 - User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents  

Federal Register 2010, 2011, 2012, 2013

This document contains amendments to the regulations relating to the imposition of user fees for enrolled agents and enrolled retirement plan agents. The final regulations lower the initial enrollment and renewal of enrollment user fees for enrolled agents and enrolled retirement plan agents and separate the enrolled retirement plan agent user fees from the enrolled agent user fees. The final......

2011-04-19

266

A amphoteric copolymer profile modification agent  

SciTech Connect

This report provides a new gel profile modification agent prepared by an amphoteric copolymer (FT-213) and a novel crosslinking agent (BY), and introduces the preparations of the amphoteric polymer, the crosslinking agent and the profile modification agent, the action mechanism, the test conditions and the evaluations of the performance of the agent. The 45 well treatments in oilfields demonstrate that the agent can be prepared conveniently, the agent has better compatibility and application performances, and the treatment life is longer with the use of the agent. 80,000 tons incremental oil and 60,000 m{sup 3} decreasing water production have been achieved.

Wang HongGuan; Yu LianCheng; Tian HongKun [Scientific Research Inst. of Petroleum Exploration and Development, Beijing (China)

1995-11-01

267

Depression: The Differing Narratives of Couples in Couple Therapy  

ERIC Educational Resources Information Center

How does the spouse of a person with depression take part in constructing narratives of depression in couple therapy? In this study we examined couples' ways of co-constructing narratives of depression in couple therapy. Three couple therapy processes were chosen for the study, one spouse in each couple having been referred to an outpatient clinic…

Rautiainen, Eija-Liisa; Aaltonen, Jukka

2010-01-01

268

Multifield coupled quintessence  

NASA Astrophysics Data System (ADS)

We study models of quintessence consisting of a number of scalar fields coupled to several dark matter components. In the case of exponential potentials the scaling solutions can be described in terms of a single field. The corresponding effective logarithmic slope and effective coupling can be written in a simple form in terms of the individual slopes and couplings of the original fields. We also investigate solutions where the scalar potential is negligible, in particular those leading to transient matter dominated solutions. Finally, we compute the evolution equations for the linear perturbations which will allow these models to be tested against current and future observational data.

Amendola, Luca; Barreiro, Tiago; Nunes, Nelson J.

2014-10-01

269

Assisted coupled quintessence  

E-print Network

We study models of quintessence consisting of a number of scalar fields coupled to several dark matter components. In the case of exponential potentials the scaling solutions can be described in terms of a single field. The corresponding effective logarithmic slope and effective coupling can be written in a simple form in terms of the individual slopes and couplings of the original fields. We also investigate solutions where the scalar potential is negligible, in particular those leading to transient matter dominated solutions. Finally, we compute the evolution equations for the linear perturbations which will allow these models to be tested against current and future observational data.

Amendola, Luca; Nunes, Nelson J

2014-01-01

270

Investigational Antimicrobial Agents of 2013  

PubMed Central

SUMMARY New antimicrobial agents are always needed to counteract the resistant pathogens that continue to be selected by current therapeutic regimens. This review provides a survey of known antimicrobial agents that were currently in clinical development in the fall of 2012 and spring of 2013. Data were collected from published literature primarily from 2010 to 2012, meeting abstracts (2011 to 2012), government websites, and company websites when appropriate. Compared to what was reported in previous surveys, a surprising number of new agents are currently in company pipelines, particularly in phase 3 clinical development. Familiar antibacterial classes of the quinolones, tetracyclines, oxazolidinones, glycopeptides, and cephalosporins are represented by entities with enhanced antimicrobial or pharmacological properties. More importantly, compounds of novel chemical structures targeting bacterial pathways not previously exploited are under development. Some of the most promising compounds include novel ?-lactamase inhibitor combinations that target many multidrug-resistant Gram-negative bacteria, a critical medical need. Although new antimicrobial agents will continue to be needed to address increasing antibiotic resistance, there are novel agents in development to tackle at least some of the more worrisome pathogens in the current nosocomial setting. PMID:24092856

Pucci, Michael J.

2013-01-01

271

Next Generation Remote Agent Planner  

NASA Technical Reports Server (NTRS)

In May 1999, as part of a unique technology validation experiment onboard the Deep Space One spacecraft, the Remote Agent became the first complete autonomous spacecraft control architecture to run as flight software onboard an active spacecraft. As one of the three components of the architecture, the Remote Agent Planner had the task of laying out the course of action to be taken, which included activities such as turning, thrusting, data gathering, and communicating. Building on the successful approach developed for the Remote Agent Planner, the Next Generation Remote Agent Planner is a completely redesigned and reimplemented version of the planner. The new system provides all the key capabilities of the original planner, while adding functionality, improving performance and providing a modular and extendible implementation. The goal of this ongoing project is to develop a system that provides both a basis for future applications and a framework for further research in the area of autonomous planning for spacecraft. In this article, we present an introductory overview of the Next Generation Remote Agent Planner. We present a new and simplified definition of the planning problem, describe the basics of the planning process, lay out the new system design and examine the functionality of the core reasoning module.

Jonsson, Ari K.; Muscettola, Nicola; Morris, Paul H.; Rajan, Kanna

1999-01-01

272

Negative-coupling resonances in pump-coupled lasers  

E-print Network

We consider coupled lasers, where the intensity deviations from the steady state, modulate the pump of the other lasers. Most of our results are for two lasers where the coupling constants are of opposite sign. This leads to a Hopf bifurcation to periodic output for weak coupling. As the magnitude of the coupling constants is increased (negatively) we observe novel amplitude effects such as a weak coupling resonance peak and, strong coupling subharmonic resonances and chaos. In the weak coupling regime the output is predicted by a set of slow evolution amplitude equations. Pulsating solutions in the strong coupling limit are described by discrete map derived from the original model.

T. W. Carr; M. L. Taylor; I. B. Schwartz

2005-10-28

273

Adaptive networks of trading agents  

NASA Astrophysics Data System (ADS)

Multiagent models have been used in many contexts to study generic collective behavior. Similarly, complex networks have become very popular because of the diversity of growth rules giving rise to scale-free behavior. Here we study adaptive networks where the agents trade “wealth” when they are linked together while links can appear and disappear according to the wealth of the corresponding agents; thus the agents influence the network dynamics and vice versa. Our framework generalizes a multiagent model of Bouchaud and Mézard [Physica A 282, 536 (2000)], and leads to a steady state with fluctuating connectivities. The system spontaneously self-organizes into a critical state where the wealth distribution has a fat tail and the network is scale free; in addition, network heterogeneities lead to enhanced wealth condensation.

Burda, Z.; Krzywicki, A.; Martin, O. C.

2008-10-01

274

Theory of agent-based market models with controlled levels of greed and anxiety  

E-print Network

We use generating functional analysis to study minority-game type market models with generalized strategy valuation updates that control the psychology of agents' actions. The agents' choice between trend following and contrarian trading, and their vigor in each, depends on the overall state of the market. Even in `fake history' models, the theory now involves an effective overall bid process (coupled to the effective agent process) which can exhibit profound remanence effects and new phase transitions. For some models the bid process can be solved directly, others require Maxwell-construction type approximations.

Papadopoulos, P

2009-01-01

275

Theory of agent-based market models with controlled levels of greed and anxiety  

NASA Astrophysics Data System (ADS)

We use generating functional analysis to study minority-game-type market models with generalized strategy valuation updates that control the psychology of agents' actions. The agents' choice between trend-following and contrarian trading, and their vigor in each, depends on the overall state of the market. Even in 'fake history' models, the theory now involves an effective overall bid process (coupled to the effective agent process) which can exhibit profound remanence effects and new phase transitions. For some models the bid process can be solved directly, others require Maxwell-construction-type approximations.

Papadopoulos, P.; Coolen, A. C. C.

2010-01-01

276

Computational Agents Descriptions in Description Logic  

Microsoft Academic Search

In this paper we present an ontology suitable for describing computational agents and computational multi-agent systems. The ontology is expressed in the description logic formalism and allows us to describe agents capabilities and to reason about them. The ontology describes agents from the communicational point of view. Further, the capabilities resulting from the built-in concept nodes architecture are described. Our

R. Vaculín

2005-01-01

277

Mobile Database Agents for Building Data Warehouses  

Microsoft Academic Search

Agent technology has a number of characteristics that make it well suited for automating information processing tasks and information retrieval. In this paper', we propose a pragmatic approach for appbing mobile agent technology within distributed database management systems (DBMSs). The developed agent environment is based on the Oracle DBMS. It dffers from other agent platforms (e.g. Aglets, Voyager) in its

Edgar Weippl; Josef Altmann; Wolfgang Essmayr

2000-01-01

278

GENERATIVE MOBILE AGENT MIGRATION IN HETEROGENEOUS ENVIRONMENTS  

Microsoft Academic Search

Agent migration, in theory, makes it possible to bring computations to the resources required. In practice, however, homogeneity in programming language and\\/or agent platform is required. This paper presents an approach that supports heterogeneous agents and platforms: agents written in dierent languages can migrate between non-identical platforms. Instead of migrating the \\

B. J. OVEREINDER; DE GROOT; N. J. E. WIJNGAARDS; F. M. T. BRAZIER

279

Learning Communication for Multi-agent Systems  

E-print Network

agents on tasks with little environmental communication, and that more complex communication strategiesLearning Communication for Multi-agent Systems C. Lee Giles1,2 and Kam-Chuen Jim2 1 School@research.nj.nec.com Abstract. We analyze a general model of multi-agent communication in which all agents communicate

Giles, C. Lee

280

A COGNITIVE AGENT ARCHITECTURE OPTIMIZED FOR ADAPTIVITY  

Microsoft Academic Search

The Engine for Composable Logical Agents with Intuitive Reorganization (ECLAIR) is a cognitive agent architecture that allows an agent to quickly adapt its behavior to new environments. ECLAIR addresses two problems in agent learning: generalizing the process of adaptation and detecting when adaptation is required. ECLAIR incorporates the main mechanisms from Piaget's Cognitive-Stage Theory of Development (10), and it uses

ANNA L. BUCZAK; KSHANTI GREENE; DAVID G. COOPER; MICHAEL CZAJKOWSKI; MARTIN O. HOFMANN

281

13 CFR 120.952 - Fiscal agent.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Fiscal agent. 120.952 Section 120.952 Business Credit...Loan Program (504) Debenture Sales and Service Agents § 120.952 Fiscal agent. SBA shall appoint a Fiscal Agent to assess...

2010-01-01

282

13 CFR 120.952 - Fiscal agent.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Fiscal agent. 120.952 Section 120.952 Business Credit...Loan Program (504) Debenture Sales and Service Agents § 120.952 Fiscal agent. SBA shall appoint a Fiscal Agent to assess...

2011-01-01

283

The Information Agent: An Infrastructure Agent Supporting Collaborative Enterprise Architectures  

E-print Network

show how services supporting time- map management, conflict resolution, deductive queries and change: conflict management, description logics, information agents, information sharing, temporal reasoning 1 it with time map management and conflict management for this purpose. 3.0 The Knowledge Management System

Fox, Mark S.

284

[Bone targeted therapies: new agents].  

PubMed

The development of bisphosphonates and anti-RANK/RANKL agents was associated with a better understanding of physiological and pathological processes of bone remodeling. New agents are now developed in this context targeting factors associated with osteoclastogenesis (TGF?, PTHrP), with signaling pathways activated during bone remodeling (Src, Cathepsin K) or with tumor cells homing into bone (chemokines). This review aims to present the underlying rationale for these developments as well as the clinical results. The emergence of new bone targeting therapies is discussed. PMID:24158596

Barth, Claire; Massard, Christophe; Vignot, Stéphane

2013-11-01

285

Multi User Learning Agent with Clustering  

NASA Astrophysics Data System (ADS)

In this paper, we propose a learning method for an agent to interact with other agents effectively. This method, MULA-C, improves efficiency of the learning, by clustering agents, and influences the learning experience of one agent to other agents which belong to the same cluster. Similarity among agents is evaluated by similarity among Q-values of agents. We give the detail explanation of learning method of MULA-C, and present the result of experiments which shows the effectiveness of MULA-C.

Ohmura, Hidefumi; Katagami, Daisuke; Nitta, Katsumi

286

Middle-Agents for the Internet  

Microsoft Academic Search

Like middle-men in physical commerce, middle-agents support the flow of information in electronic commerce, assisting in locating and connecting the ultimate information provider with the ultimate information requester. Many different types of middle-agents will be useful in realistic, large, distributed, open multi-agent problem solving systems. These include matchmakers or yellow page agents that process advertisements, blackboard agents that collect requests,

Keith Decker; Katia P. Sycara; Mike Williamson

1997-01-01

287

The Psi Calculus: An Algebraic Agent Language  

Microsoft Academic Search

? is a novel algebraic language for the specification of agents, such as BDI agents, which employ a sense-compute-act computation\\u000a cycle and stored plan execution as the basis of agent behaviour. It generalizes and extends agent architectures such as PRS\\u000a and dMARS in several ways, and possesses a complete operational semantics covering all aspects of agent computation from intention\\u000a step

David Kinny

2001-01-01

288

Agents in bioinformatics, computational and systems biology  

Microsoft Academic Search

The adoption of agent technologies and multi-agent systems constitutes an emerging area in bioinformatics. In this article, we report on the activity of the Working Group on Agents in Bioinformatics (BIOAGENTS) founded during the first AgentLink III Technical Forum meeting on the 2nd of July, 2004, in Rome. The meeting provided an opportunity for seeding collaborations between the agent and

Emanuela Merelli; Giuliano Armano; Nicola Cannata; Flavio Corradini; Mark D'inverno; Andreas Doms; Phillip W. Lord; Andrew Martin; Luciano Milanesi; Steffen Möller; Michael Schroeder; Michael Luck

2007-01-01

289

Limonene and tetrahydrofurfuryl alcohol cleaning agent  

DOEpatents

The present invention is a tetrahydrofurfuryl alcohol and limonene or terpineol cleaning agent and method for formulating and/or using the cleaning agent. This cleaning agent effectively removes both polar and nonpolar contaminants from various electrical and mechanical parts and is readily used without surfactants, thereby reducing the need for additional cleaning operations. The cleaning agent is warm water rinsable without the use of surfactants. The cleaning agent can be azeotropic, enhancing ease of use in cleaning operations and ease of recycling.

Bohnert, George W. (Harrisonville, MO); Carter, Richard D. (Lee's Summit, MO); Hand, Thomas E. (Lee's Summit, MO); Powers, Michael T. (Santa Rosa, CA)

1996-05-07

290

Limonene and tetrahydrofurfurly alcohol cleaning agent  

DOEpatents

The present invention is a tetrahydrofurfuryl alcohol and limonene cleaning agent and method for formulating and/or using the cleaning agent. This cleaning agent effectively removes both polar and nonpolar contaminants from various electrical and mechanical parts and is readily used without surfactants, thereby reducing the need for additional cleaning operations. The cleaning agent is warm water rinsable without the use of surfactants. The cleaning agent can be azeotropic, enhancing ease of use in cleaning operations and ease of recycling.

Bohnert, George W. (Harrisonville, MO); Carter, Richard D. (Lee's Summit, MO); Hand, Thomas E. (Lee's Summit, MO); Powers, Michael T. (Santa Rosa, CA)

1997-10-21

291

Migration Dynamics in Artificial Agent Societies  

E-print Network

Abstract—An Artificial Agent Society can be defined as a collection of agents interacting with each other for some purpose and/or inhabiting a specific locality, possibly in accordance to some common norms/rules. These societies are analogous to human and ecological societies, and are an expanding and emerging field in research about social systems. Social networks, electronic markets and disaster management organizations can be viewed as such artificial (open) agent societies and can be best understood as computational societies. Members of such artificial agent societies are heterogeneous intelligent software agents which are operating locally and cooperating and coordinating with each other in order to achieve goals of an agent society. These artificial agent societies have some kind of dynamics existing in them in terms of dynamics of Agent Migration, Role-Assignment, Norm-Emergence, Security and Agent-Interaction. In this paper, we have described the dynamics of agent migration process, starting from the various types of agent migration, causes or reasons for agent migration, consequences of agent migration, and an agent migration framework to model the its behavior for migration of agents between societies. I.

Harjot Kaur; Karanjeet Singh Kahlon; Rajinder Singh Virk

292

An Autonomous Spacecraft Agent Prototype  

Microsoft Academic Search

This paper describes the New Millennium Remote Agent (NMRA) architecture for autonomous spacecraft control systems. The architecture supports challenging requirements of the autonomous spacecraft domain not usually addressed in mobile robot architectures, including highly reliable autonomous operations over extended time periods in the presence of tight resource constraints, hard deadlines, limited observability, and concurrent activity. A hybrid architecture, NMRA integrates

Barney Pell; Douglas E. Bernard; Steve A. Chien; Erann Gat; Nicola Muscettola; P. Pandurang Nayak; Michael D. Wagner; Brian C. Williams

1998-01-01

293

Natural products as antibacterial agents  

Microsoft Academic Search

For thousands of years medicinal plants have played a significant role in the treatment of a wide range of medical conditions, including infectious diseases. Some naturally occurring chemical compounds serve as models for a large percentage clinically proven drugs, and many are now being re-assessed as antimicrobial agents. The primary reason for this renaissance is the fact that infectious disease

Gail B. Mahady; Yue Huang; Brian J. Doyle; Tracie Locklear

2008-01-01

294

Training and Supporting Linking Agents.  

ERIC Educational Resources Information Center

The purpose of this chapter is to present a view of the realities facing those playing linking roles and to give direction to renewed efforts to develop training and support mechanisms for linking agents. The first section of the chapter presents the assumptions underlying the paper. The second consists of four principal subsections. The first…

Crandall, David P.

295

An Introduction to Software Agents  

Microsoft Academic Search

ince the beginning of recorded history, people have been fascinated with the idea of non-human agencies.1 Popular notions about androids, hu- manoids, robots, cyborgs, and science fiction creatures permeate our cul- ture, forming the unconscious backdrop against which software agents are per- ceived. The word \\

Jeffrey M. Bradshaw

1997-01-01

296

Symposium on antimicrobial agents. Metronidazole.  

PubMed

Metronidazole, a nitroimidazole derivative, is a unique antimicrobial agent that is active against both bacterial and parasitic organisms, although only the anaerobic members of these groups are susceptible. It has been used for the treatment of trichomoniasis for almost 30 years and is also effective in amebiasis and giardiasis. More recently, metronidazole has emerged as a principal agent for the treatment of anaerobic infections. It is highly effective against all species of anaerobes except certain non-spore-forming gram-positive bacilli and cocci and is the only agent rapidly bactericidal against the Bacteroides fragilis group. The hydroxy metabolite is 65% as effective as metronidazole and may play a major therapeutic role. Clinical studies have substantiated its efficacy for prophylaxis during elective colorectal surgical procedures and the treatment of deep abdominal sepsis (usually in combination with another agent such as an aminoglycoside). Metronidazole is the treatment of choice for bacterial vaginosis and seems to be as effective as vancomycin for treatment of Clostridium difficile-related diarrhea and colitis. Good blood levels are produced after both oral and intravenous administration, and side effects are infrequent and minimal. Metronidazole should not be taken during the first trimester of pregnancy because of concerns about mutagenicity. Tinidazole and ornidazole are recently developed nitroimidazole derivatives that have even greater antimicrobial activity than metronidazole. PMID:3312851

Rosenblatt, J E; Edson, R S

1987-11-01

297

Improving agents using reliable communication  

NASA Astrophysics Data System (ADS)

Recent advances in introspective modalities and linear time symmetries do not necessarily obviate the need for web browsers [1]. In our research, we disprove the exploration of agents, which embodies the appropriate principles of electrical engineering. Here we demonstrate that even though semaphores and XML [1] are mostly incompatible, randomized algorithms and write-back caches are mostly incompatible.

Zheng, Jinbin

2013-10-01

298

An Autonomous Spacecraft Agent Prototype  

NASA Technical Reports Server (NTRS)

This paper describes the New Millennium Remote Agent (NMRA) architecture for autonomous spacecraft control systems. This architecture integrates traditional real-time monitoring and control with constraint-based planning and scheduling, robust multi-threaded execution, and model-based diagnosis and reconfiguration.

Pell, Barney; Bernard, Douglas E.; Chien, Steve A.; Gat, Erann; Muscettola, Nicola; Nayak, P. Pandurang; Wagner, Michael D.; Williams, Brian C.

1997-01-01

299

Voter models with contrarian agents.  

PubMed

In the voter and many other opinion formation models, agents are assumed to behave as congregators (also called the conformists); they are attracted to the opinions of others. In this study I investigate linear extensions of the voter model with contrarian agents. An agent is either congregator or contrarian and assumes a binary opinion. I investigate three models that differ in the behavior of the contrarian toward other agents. In model 1, contrarians mimic the opinions of other contrarians and oppose (i.e., try to select the opinion opposite to) those of congregators. In model 2, contrarians mimic the opinions of congregators and oppose those of other contrarians. In model 3, contrarians oppose anybody. In all models, congregators are assumed to like anybody. I show that even a small number of contrarians prohibits the consensus in the entire population to be reached in all three models. I also obtain the equilibrium distributions using the van Kampen small-fluctuation approximation and the Fokker-Planck equation for the case of many contrarians and a single contrarian, respectively. I show that the fluctuation around the symmetric coexistence equilibrium is much larger in model 2 than in models 1 and 3 when contrarians are rare. PMID:24329314

Masuda, Naoki

2013-11-01

300

An autonomous spacecraft agent prototype  

Microsoft Academic Search

. This paper describes the New Millennium Remote Agent (NMRA) architecture for autonomousspacecraft control systems. The architecture supports challenging requirements of the autonomousspacecraft domain not usually addressed in mobile robot architectures, including highly reliableautonomous operations over extended time periods in the presence of tight resource constraints, harddeadlines, limited observability, and concurrent activity. A hybrid architecture, NMRA integrates traditional...

Barney Pell; Douglas E. Bernard; Steve A. Chien; Erann Gat; Nicola Muscettola; P. Pandurang Nayak; Michael D. Wagner; Brian C. Williams

1997-01-01

301

An Autonomous Spacecraft Agent Prototype  

Microsoft Academic Search

. This paper describes the New Millennium Remote Agent (NMRA) architecture for autonomous spacecraft control systems. The architecture supports challenging requirements of the autonomous spacecraft domain not usually addressed in mobile robot architectures, including highly reliable autonomous operations over extended time periods in the presence of tight resource constraints, hard deadlines, limited observability, and concurrent activity. A hybrid architecture, NMRA

Barney Pell; Douglas E. Bernard; Steve A. Chien; Erann Gat; Nicola Muscettola; P. Pandurang Nayak; Michael D. Wagner; Brian C. Williams

1998-01-01

302

The Power Trading Agent Competition  

Microsoft Academic Search

This is the specification for the Power Trading Agent Competition for 2012 (Power TAC 2012). Power TAC is a competitive simulation that models a “liberalized” retail electrical energy market, where competing business entities or “brokers” offer energy services to customers through tariff contracts, and must then serve those customers by trading in a wholesale market. Brokers are challenged to maximize

Wolfgang Ketter; John Collins; Prashant Reddy; Christoph Flath; Mathijs Weerdt

2011-01-01

303

Reflective Agents for Adaptive Workflows  

Microsoft Academic Search

Adaptation to changes in organizational procedures and business rules is a sine qua non for workflow management systems, if they have to be useful to organizations. This paper describes an approach based on workflow agents capable of managing dynamic changes in business policies. The two key aspects of our approach are (i) the agentification of the process engine, in the

Uwe M. Borghoff; Paolo Bottoni; Piero Mussio; Remo Pareschi

1997-01-01

304

RCS: An Intelligent Agent Architecture  

Microsoft Academic Search

RCS (Real-time Control System) is an intelligent agent architecture designed to enable any level of intelligent behavior, up to and including human levels of performance. RCS was inspired 30 years ago by a theoretical model of the cerebellum, the portion of the brain responsible for fine motor coordination and control of conscious motions. It was originally designed for sensory-interactive goal-

Jim Albus; Tony Barbera; Craig Schlenoff

305

Believable Social and Emotional Agents.  

National Technical Information Service (NTIS)

One of the key steps in creating quality interactive drama is the ability to create quality interactive characters (or believable agents). Two important aspects of such characters will be that they appear emotional and that they can engage in social inter...

W. S. Reilly

1996-01-01

306

Institutional Researchers as Change Agents  

ERIC Educational Resources Information Center

The future challenge and opportunity for institutional researchers is to serve as change agents with involvement in initiating, implementing, and evaluating campus work. Institutional researchers are poised to excel at doing so because of the array of technical skills they routinely apply to existing institutional research roles. Their work…

Swing, Randy L.

2009-01-01

307

Coupled adaptive complex networks  

NASA Astrophysics Data System (ADS)

Adaptive networks, which combine topological evolution of the network with dynamics on the network, are ubiquitous across disciplines. Examples include technical distribution networks such as road networks and the internet, natural and biological networks, and social science networks. These networks often interact with or depend upon other networks, resulting in coupled adaptive networks. In this paper we study susceptible-infected-susceptible (SIS) epidemic dynamics on coupled adaptive networks, where susceptible nodes are able to avoid contact with infected nodes by rewiring their intranetwork connections. However, infected nodes can pass the disease through internetwork connections, which do not change with time: The dependencies between the coupled networks remain constant. We develop an analytical formalism for these systems and validate it using extensive numerical simulation. We find that stability is increased by increasing the number of internetwork links, in the sense that the range of parameters over which both endemic and healthy states coexist (both states are reachable depending on the initial conditions) becomes smaller. Finally, we find a new stable state that does not appear in the case of a single adaptive network but only in the case of weakly coupled networks, in which the infection is endemic in one network but neither becomes endemic nor dies out in the other. Instead, it persists only at the nodes that are coupled to nodes in the other network through internetwork links. We speculate on the implications of these findings.

Shai, S.; Dobson, S.

2013-04-01

308

Software for Automation of Real-Time Agents, Version 2  

NASA Technical Reports Server (NTRS)

Version 2 of Closed Loop Execution and Recovery (CLEaR) has been developed. CLEaR is an artificial intelligence computer program for use in planning and execution of actions of autonomous agents, including, for example, Deep Space Network (DSN) antenna ground stations, robotic exploratory ground vehicles (rovers), robotic aircraft (UAVs), and robotic spacecraft. CLEaR automates the generation and execution of command sequences, monitoring the sequence execution, and modifying the command sequence in response to execution deviations and failures as well as new goals for the agent to achieve. The development of CLEaR has focused on the unification of planning and execution to increase the ability of the autonomous agent to perform under tight resource and time constraints coupled with uncertainty in how much of resources and time will be required to perform a task. This unification is realized by extending the traditional three-tier robotic control architecture by increasing the interaction between the software components that perform deliberation and reactive functions. The increase in interaction reduces the need to replan, enables earlier detection of the need to replan, and enables replanning to occur before an agent enters a state of failure.

Fisher, Forest; Estlin, Tara; Gaines, Daniel; Schaffer, Steve; Chouinard, Caroline; Engelhardt, Barbara; Wilklow, Colette; Mutz, Darren; Knight, Russell; Rabideau, Gregg; Chien, Steve; Simmons, Reid; Apfelbaum, David

2005-01-01

309

Social Norms accentuate agent trust and attenuate agent Henry Hexmoor and Prapulla Poli  

E-print Network

-agent system. Study of social norms is essential for creating predictable behavior among agents in an E-society ]. Agents' interactions in a society are often guided by social actions such as norms [Hexmoor, Battula 2003Social Norms accentuate agent trust and attenuate agent autonomy Henry Hexmoor and Prapulla Poli

Hexmoor, Henry

310

Is it an Agent, or Just a Program?: A Taxonomy for Autonomous Agents  

Microsoft Academic Search

The advent of software agents gave rise to much discussion of just what such an agent is, and of how they differ from programs in general. Here we propose a formal definition of an autonomous agent which clearly distinguishes a software agent from just any program. We also offer the beginnings of a natural kinds taxonomy of autonomous agents, and

Stan Franklin; Arthur C. Graesser

1996-01-01

311

Is it an agent or just a program?: A taxonomy for autonomous agents  

Microsoft Academic Search

Abstract The advent of software agents gave rise to much discussion of just what such an agent is, and of how they differ from programs in general. Here we propose a formal definition of an autonomous agent which clearly distinguishes a software agent from just any program. We also offer the beginnings of a natural kinds taxonomyo f autonomous agents,

Stan Franklin

1997-01-01

312

An Operational Semantics for the Single Agent Core of AGENT0  

E-print Network

the mental states of agents change over time. In the programming language so-called commitment rules are usedAn Operational Semantics for the Single Agent Core of AGENT0 Koen V. Hindriks, Frank S. de Boer.089, 3508 TB Utrecht, The Netherlands fkoenh,frankb,wiebe,jjg@cs.uu.nl Abstract AGENT0 is an agent

Utrecht, Universiteit

313

Animated agents in K-12 engineering outreach: Preferred agent characteristics across age levels  

E-print Network

for animated agents and their individual characteristics, or how those preferences change accord- ingAnimated agents in K-12 engineering outreach: Preferred agent characteristics across age levels Amy 30 March 2013 Keywords: Age levels Agent characteristics Animated agent K-12 outreach a b s t r a c

Reisslein, Martin

314

Swarm autonomic agents with self-destruct capability  

NASA Technical Reports Server (NTRS)

Systems, methods and apparatus are provided through which in some embodiments an autonomic entity manages a system by generating one or more stay alive signals based on the functioning status and operating state of the system. In some embodiments, an evolvable synthetic neural system is operably coupled to one or more evolvable synthetic neural systems in a hierarchy. The evolvable neural interface receives and generates heartbeat monitor signals and pulse monitor signals that are used to generate a stay alive signal that is used to manage the operations of the synthetic neural system. In another embodiment an asynchronous Alice signal (Autonomic license) requiring valid credentials of an anonymous autonomous agent is initiated. An unsatisfactory Alice exchange may lead to self-destruction of the anonymous autonomous agent for self-protection.

Hinchey, Michael G. (Inventor); Sterritt, Roy (Inventor)

2009-01-01

315

From actors to agents in socio-ecological systems models  

PubMed Central

The ecosystem service concept has emphasized the role of people within socio-ecological systems (SESs). In this paper, we review and discuss alternative ways of representing people, their behaviour and decision-making processes in SES models using an agent-based modelling (ABM) approach. We also explore how ABM can be empirically grounded using information from social survey. The capacity for ABM to be generalized beyond case studies represents a crucial next step in modelling SESs, although this comes with considerable intellectual challenges. We propose the notion of human functional types, as an analogy of plant functional types, to support the expansion (scaling) of ABM to larger areas. The expansion of scope also implies the need to represent institutional agents in SES models in order to account for alternative governance structures and policy feedbacks. Further development in the coupling of human-environment systems would contribute considerably to better application and use of the ecosystem service concept. PMID:22144388

Rounsevell, M. D. A.; Robinson, D. T.; Murray-Rust, D.

2012-01-01

316

Swarm autonomic agents with self-destruct capability  

NASA Technical Reports Server (NTRS)

Systems, methods and apparatus are provided through which in some embodiments an autonomic entity manages a system by generating one or more stay alive signals based on the functioning status and operating state of the system. In some embodiments, an evolvable synthetic neural system is operably coupled to one or more evolvable synthetic neural systems in a hierarchy. The evolvable neural interface receives and generates heartbeat monitor signals and pulse monitor signals that are used to generate a stay alive signal that is used to manage the operations of the synthetic neural system. In another embodiment an asynchronous Alice signal (Autonomic license) requiring valid credentials of an anonymous autonomous agent is initiated. An unsatisfactory Alice exchange may lead to self-destruction of the anonymous autonomous agent for self-protection.

Hinchey, Michael G. (Inventor); Sterritt, Roy (Inventor)

2011-01-01

317

Coupled Airy breathers  

E-print Network

The dynamics of two component coupled Airy beams is investigated. In the linear propagation regime a complete analytic solution describes breather like propagation of the two components featuring non-diffracting self-accelerating Airy behavior. The superposition of two beams with different input properties opens the possibility to design more complex non-diffracting propagation scenarios. In the strongly nonlinear regime the dynamics remains qualitatively robust as is revealed by direct numerical simulations. Due to the Kerr effect the two beams emit solitonic breathers, whose coupling period is compatible with the remaining Airy-like beams. The results of this study are relevant for the description of photonic and plasmonic beams propagating in coupled planar waveguides as well as for birefrigent or multi-wavelengths beams.

Driben, R; Meier, T

2014-01-01

318

Coupling gravitons to matter.  

PubMed

Using relationships between open and closed strings, we present a construction of tree-level scattering amplitudes for gravitons minimally coupled to matter in terms of gauge theory partial amplitudes. In particular, we present examples of amplitudes with gravitons coupled to vectors or to a single fermion pair. We also present two examples with massive graviton exchange, as would arise in the presence of large compact dimensions. The gauge charges are represented by flavors of dynamical scalars or fermions. This also leads to an unconventional decomposition of color and kinematics in gauge theories. PMID:11019138

Bern, Z; De Freitas, A; Wong, H L

2000-04-17

319

Coupled Transport Protein Systems  

NSDL National Science Digital Library

This set of animated lessons provides examples of how transport proteins interact in coupled systems to produce physiologic effects. The gastric pumps animation depicts the secretion of hydrochloric acid into the gastric lumen. The animation called glucose absorption depicts glucose absorption by intestinal epithelial cells. The CFTR animation explains how the cystic fibrosis conductance transmembrane regulator (CFTR) functions as a key component of a coupled system of transport proteins that clears the pulmonary system of mucus and inhaled particulates. These animations serve as valuable resources for any collegiate-level course that describes these processes. Courses that might use them include introductory biology, biochemistry, biophysics, cell biology, pharmacology, and physiology.

Jack D. Thatcher (Lewisburg;West Virginia School of Osteopathic Medicine REV)

2013-04-16

320

Beyond EDI: An Agent’s Role in the Cloud  

Microsoft Academic Search

This year has garnered ample conversation and controversy regarding new cloud?based ILS systems and their value to libraries. The emphasis of these discussions has been on integrating cloud?based systems with database services\\/aggregators and libraries, but there has been very little mention of the Agent or Information Solutions Provider (ISP). Is there a role for the ISP in this new medium?

Christine M. Stamison; Anne Campbell; Michael Winkler

2012-01-01

321

Inverse agonism or neutral antagonism at G-protein coupled receptors: A medicinal chemistry challenge worth pursuing?  

Microsoft Academic Search

The identification of constitutive, or intrinsic, activity of G-protein coupled receptors has had major impact on receptor theory, the identification of agents that inhibit this ligand-independent receptor activity has led, in turn, to the concept of inverse agonism. It has subsequently emerged that the majority, around 85%, of all known G-protein coupled receptor antagonists are, in fact, inverse agonists. Agents

Peter J. Greasley; John C. Clapham

2006-01-01

322

Coevolutionary networks of reinforcement-learning agents  

NASA Astrophysics Data System (ADS)

This paper presents a model of network formation in repeated games where the players adapt their strategies and network ties simultaneously using a simple reinforcement-learning scheme. It is demonstrated that the coevolutionary dynamics of such systems can be described via coupled replicator equations. We provide a comprehensive analysis for three-player two-action games, which is the minimum system size with nontrivial structural dynamics. In particular, we characterize the Nash equilibria (NE) in such games and examine the local stability of the rest points corresponding to those equilibria. We also study general n-player networks via both simulations and analytical methods and find that, in the absence of exploration, the stable equilibria consist of star motifs as the main building blocks of the network. Furthermore, in all stable equilibria the agents play pure strategies, even when the game allows mixed NE. Finally, we study the impact of exploration on learning outcomes and observe that there is a critical exploration rate above which the symmetric and uniformly connected network topology becomes stable.

Kianercy, Ardeshir; Galstyan, Aram

2013-07-01

323

Neuroprotective "agents" in surgery. Secret "agent" man, or common "agent" machine?  

NASA Technical Reports Server (NTRS)

The search for clinically-effective neuroprotective agents has received enormous support in recent years--an estimated $200 million by pharmaceutical companies on clinical trials for traumatic brain injury alone. At the same time, the pathophysiology of brain injury has proved increasingly complex, rendering the likelihood of a single agent "magic bullet" even more remote. On the other hand, great progress continues with technology that makes surgery less invasive and less risky. One example is the application of endovascular techniques to treat coronary artery stenosis, where both the invasiveness of sternotomy and the significant neurological complication rate (due to microemboli showering the cerebral vasculature) can be eliminated. In this paper we review aspects of intraoperative neuroprotection both present and future. Explanations for the slow progress on pharmacologic neuroprotection during surgery are presented. Examples of technical advances that have had great impact on neuroprotection during surgery are given both from coronary artery stenosis surgery and from surgery for Parkinson's disease. To date, the progress in neuroprotection resulting from such technical advances is an order of magnitude greater than that resulting from pharmacologic agents used during surgery. The progress over the last 20 years in guidance during surgery (CT and MRI image-guidance) and in surgical access (endoscopic and endovascular techniques) will soon be complemented by advances in our ability to evaluate biological tissue intraoperatively in real-time. As an example of such technology, the NASA Smart Probe project is considered. In the long run (i.e., in 10 years or more), pharmacologic "agents" aimed at the complex pathophysiology of nervous system injury in man will be the key to true intraoperative neuroprotection. In the near term, however, it is more likely that mundane "agents" based on computers, microsensors, and microeffectors will be the major impetus to improved intraoperative neuroprotection.

Andrews, R. J.

1999-01-01

324

Applying a Multi-Agent Model to Evaluate Effects of Development Proposals and Growth Management  

E-print Network

commercial development stress municipalities providing services such as clean water, waste management, and fire and police protection. The dynamics of expanding development is influenced by complex interactions decisions. This paper presents a multi-agent model coupled with a GIS-based land-use potential model

Monticino, Michael

325

Polypropylene–clay nanocomposites: effect of compatibilizing agents on clay dispersion  

Microsoft Academic Search

In this work, polypropylene–clay nanocomposites are obtained and studied by using two different coupling agents, diethyl maleate and maleic anhydride. Two different clays, a commercial montmorillonite (Nanomer I30.TC) and a sodium bentonite purified and modified with octadecylammonium ions have also been used. The relative influence of each factor, matrix and clay modification, can be observed from structural analysis (SAXS, TEM)

D. Garc??a-López; O. Picazo; J. C. Merino; J. M. Pastor

2003-01-01

326

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition  

PubMed Central

The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using “click chemistry.” The preliminary biological evaluation of triazole-cycloproparadicicol is also reported. PMID:21442009

Lei, Xiaoguang; Danishefsky, Samuel J.

2011-01-01

327

Analysing the Performance of Optimistic Synchronisation Algorithms in Simulations of Multi-Agent Systems  

Microsoft Academic Search

In this paperwe present a detailed analysisof the perfor- mance of the Decision Theoretic Read Delay (DTRD) opti- mistic synchronisation algorithm for simulations of Multi- Agent Systems. We develop an abstract characterisation of the access patterns found in MAS simulations based on the simulation's degree of coupling and skew. Using this char- acterisation, we generatedstereotypicaltest cases which we used to

Michael Lees; Brian Logan; Dan Chen; Ton Oguara; Georgios K. Theodoropoulos

2006-01-01

328

Coupled Resonant Pendulums  

NSDL National Science Digital Library

This site from the Exploratorium provides a demonstration, using everyday materials, of the energy exchange between two coupled pendulums. The site provides a thorough description of how the two pendulums interact and contrasts their motion. The site also describes an easy to find the rate of energy exchange.

2006-10-12

329

A Pious Couple  

E-print Network

, selling fruit, raising and selling pigs, selling produce from greenhouses, driving tractors, and so on. Most families own cows for milk. ?????????????????????????????????????????????????? ??????? ????? ??????? ?????? ????? ?????? ?????? ?????? ??... ????????????????????????????????????? ????????? Rdo rje don ‘grub (b. 1985) recorded 25 folktales in June and July 2010 in Rta rgyugs Village. Rgyal mtshan (b. 1935) told 17 stories: A Pious Couple; A Mistreated Householder; Barley Seed Son; Donkey and Tiger; Ghost Mother; Painter Kun dga...

Rdo rje don 'grub

2011-01-01

330

Agent Behavior Choice on Civil Business in China’s Military Industry: A Multitask Agent Analysis  

Microsoft Academic Search

\\u000a Agent’s behavior choice affects civil business performance in military industry. We built a multitask agent model to analyze\\u000a agent behavior choice in China’s military industry on civil business. We find that because of the rigidity nature, the volatility\\u000a of military task intensity and the volatility of fixed salary, the agent’s efforts on civil business would be inadequate and\\u000a lack of

Lei Liu; Yenan Zhou

331

[Safety profile of antimicrobial agents].  

PubMed

Many antibiotics have been developed and used for the treatment of infectious diseases. Although they have been known to have various adverse effects, most of the mechanisms remain still unknown. New quinolones are well known to induce convulsions and their convulsant activity enhanced by concurrent administration of anti-inflammatory drugs. Each new quinolone has an individual convulsant activity with individual drug-interaction with anti-inflammatory drugs. And enoxacin, lomefloxacin and gatifloxacin have been reported to decrease blood glucose levels in a dose-depend- ent manner, but ciprofloxacin and levofloxacin had no effect on the levels. It should be important to know the safety profile of antimicrobial agents before doctors administer these agents to the patients with infectious diseases. PMID:21963968

Hori, Seiji

2011-01-01

332

Novel Antiangiogenic Agents in Dermatology  

PubMed Central

Because angiogenesis underlies the pathogenesis of numerous conditions (cancer, psoriasis, macular degeneration), there is a pressing need for continued investigations into angiogenic signaling and potential drug targets. Antiangiogenic agents can be classified as either direct or indirect. Direct antiangiogenics act on untransformed endothelial cells to prevent differentiation and proliferation; indirect antiangiogenics act to inhibit factors involved in proangiogenic signaling. Agents currently available with dermatologic indications are few, while several established and novel biologics targeting various proangiogenic factors are currently being investigated for potential dermatologic uses, but the jury is still out on their efficacy and safety. In this review, we highlight our experience with a group of existing and novel, small molecules that combine several modes of action against angiogenesis in addition to other properties – triarylmethane dyes and fulvene derivatives. PMID:21172300

Berrios, Ricardo L.; Arbiser, Jack L.

2011-01-01

333

Proarrhythmic Potential of Antimicrobial Agents  

Microsoft Academic Search

Several antiarrhythmic and non-cardiovascular drug therapies including antimicrobial agents have been implicated as the causes\\u000a for QT interval prolongation, torsades de pointes (TdP) ventricular tachycardia and sudden cardiac death. Most of the drugs\\u000a that have been associated with the lengthening of the QT interval or development of TdP can also block the rapidly activating\\u000a component of the delayed rectifier potassium

J. Simkó; A. Csilek; J. Karászi; I. L?rincz

2008-01-01

334

L -Nucleosides as Chemotherapeutic Agents  

Microsoft Academic Search

Nucleoside analogs have been a major class of chemotherapeutic agents. Currently, more than 30 commercially available antiviral\\u000a and antitumor nucleosides and nucleoside analogs are available. Among nucleoside analogs, nonnatural L-enantiomers have been\\u000a particularly interesting. The most notable example is lamivudine, which has been playing an important role in the treatment\\u000a of human immunodeficiency virus and hepatitis B virus infections. The

Giuseppe Gumina; Youhoon Chong; Chung K. Chu

335

Agents' Interaction in Virtual Storytelling  

Microsoft Academic Search

In this paper we describe a fully implemented prototype for interactive storytelling using the Unreal™ engine. Using a sit-com like scenario as an example of how the dynamic interactions between agents and\\/or the user dramatise the emerging story. Hierarchical Task Networks (HTNs) are formalised using AND\\/OR graphs, which are used to describe the many possible variations of the story at

Marc Cavazza; Fred Charles; Steven J. Mead

2001-01-01

336

Linezolid: an oxazolidinone antimicrobial agent  

Microsoft Academic Search

Background: Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium infections. It also is indicated for the treatment of uncomplicated skin and skin-structure infections caused by methicillin-sensitive S

Horatio B. Fung; Harold L. Kirschenbaum; Babatunde O. Ojofeitimi

2001-01-01

337

Affective Computing for Future Agents  

Microsoft Academic Search

\\u000a To the extent that future agents will interact with people and with one another via text, speech, and other modes that suggest\\u000a social interaction, they may benefit from having certain skills of social-emotional intelligence, such as the ability to see\\u000a if they have annoyed a person. Already, many animated characters have the ability to express emotion (give the appearance\\u000a of

Rosalind W. Picard

2000-01-01

338

Effictiveness of non-commercial cleaning agents verses commercial agents Samantha Stultz  

E-print Network

Effictiveness of non-commercial cleaning agents verses commercial agents Samantha Stultz Nuclear Medicine Technology, IU School of Medicine This study determined the efficiency of using non -commercial

Zhou, Yaoqi

339

Chemotherapy and Dietary Phytochemical Agents  

PubMed Central

Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way. PMID:23320169

Sak, Katrin

2012-01-01

340

Representation and purposeful autonomous agents  

Microsoft Academic Search

Although many researchers feel that an autonomous system, capable of behaving appropriately in an uncertain environment, must have an internal representation (world model) of entities, events and situations it perceives in the world, research into active vision, inattentional amnesia has implications for our views on the content of represented knowledge and raises issues concerning coupling knowledge held in the longer

Sharon Wood

2004-01-01

341

Emergent Behavior of Coupled Barrier Island - Resort Systems  

NASA Astrophysics Data System (ADS)

Barrier islands are attractive sites for resorts. Natural barrier islands experience beach erosion and island overwash during storms, beach accretion and dune building during inter-storm periods, and migration up the continental shelf as sea level rises. Beach replenishment, artificial dune building, seawalls, jetties and groins have been somewhat effective in protecting resorts against erosion and overwash during storms, but it is unknown how the coupled system will respond to long-term sea level rise. We investigate coupled barrier island - resort systems using an agent-based model with three components: natural barrier islands divided into a series of alongshore cells; resorts controlled by markets for tourism and hotel purchases; and coupling via storm damage to resorts and resort protection by government agents. Modeled barrier islands change by beach erosion, island overwash and inlet cutting during storms, and beach accretion, tidal delta growth and dune and vegetation growth between storms. In the resort hotel market, developer agents build hotels and hotel owning agents purchase them using predictions of future revenue and property appreciation, with the goal of maximizing discounted utility. In the tourism market, hotel owning agents set room rental prices to maximize profit and tourist agents choose vacation destinations maximizing a utility based on beach width, price and word-of-mouth. Government agents build seawalls, groins and jetties, and widen the beach and build up dunes by adding sand to protect resorts from storms, enhance beach quality, and maximize resort revenue. Results indicate that barrier islands and resorts evolve in a coupled manner to resort size saturation, with resorts protected against small-to-intermediate-scale storms under fairly stable sea level. Under extended, rapidly rising sea level, protection measures enhance the effect of large storms, leading to emergent behavior in the form of limit cycles or barrier submergence, depending on the relative rates of resort recovery from storms and sea level rise. The model is applied to Ocean City, Maryland and neighboring undeveloped Assateague Island National Seashore. Supported by the National Science Foundation, Geology and Paleontology Program, and the Andrew W. Mellon Foundation

McNamara, D. E.; Werner, B. T.

2004-12-01

342

Nerve Agents ATSDR ? General Information 1  

E-print Network

Nerve Agents ATSDR ? General Information 1 Nerve Agents Tabun (GA) CAS 77-81-6; Sarin (GB) CAS 107 are heavier thanair. Odor does not provide adequate warning of detection. The estimated LCt50 (the product

Baloh, Bob

343

Learning other agents` preferences in multiagent negotiation  

SciTech Connect

In multiagent systems, an agent does not usually have complete information about the preferences and decision making processes of other agents. This might prevent the agents from making coordinated choices, purely due to their ignorance of what others want. This paper describes the integration of a learning module into a communication-intensive negotiating agent architecture. The learning module gives the agents the ability to learn about other agents` preferences via past interactions. Over time, the agents can incrementally update their models of other agents` preferences and use them to make better coordinated decisions. Combining both communication and learning, as two complement knowledge acquisition methods, helps to reduce the amount of communication needed on average, and is justified in situations where communication is computationally costly or simply not desirable (e.g. to preserve the individual privacy).

Bui, H.H.; Kieronska, D.; Venkatesh, S. [Curtin Univ. of Technology, Perth, WA (Australia)

1996-12-31

344

Agent design to pass computer games  

Microsoft Academic Search

The creation of intelligent, human-like agents becomes increasingly eminent in the development of computer games. This paper discusses how the Turing Test might be applied to computer games to find an appropriate design for such an agent.

Astrid Glende

2004-01-01

345

Intelligent Agents as Cognitive Tools for Education.  

ERIC Educational Resources Information Center

Examines the educational potential for intelligent agents as cognitive tools. Discusses the role of intelligent agents: managing large amounts of information (information overload), serving as a pedagogical expert, and creating programming environments for the learner. (AEF)

Baylor, Amy

1999-01-01

346

Security Measures to Protect Mobile Agents  

NASA Astrophysics Data System (ADS)

The security issues of mobile agent systems have embarrassed its widespread implementation. Mobile agents that move around the network are not safe because the remote hosts that accommodate the agents initiates all kinds of attacks. These hosts try to analyze the agent's decision logic and their accumulated data. So, mobile agent security is the most challenging unsolved problems. The paper analyzes various security measures deeply. Security especially the attacks performed by hosts to the visiting mobile agent (the malicious hosts problem) is a major obstacle that prevents mobile agent technology from being widely adopted. Being the running environment for mobile agent, the host has full control over them and could easily perform many kinds of attacks against them.

Dadhich, Piyanka; Govil, M. C.; Dutta, Kamlesh

2010-11-01

347

Soft Tissue Sarcomas and Agent Orange  

MedlinePLUS

... Toll Free Numbers VA » Health Care » Public Health » Military Exposures » Agent Orange » Veterans' Diseases Associated with Agent ... Orange Public Health Public Health Public Health Home Military Exposures Military Exposures Home 4 Ways to Find ...

348

Porphyria Cutanea Tarda and Agent Orange  

MedlinePLUS

... Toll Free Numbers VA » Health Care » Public Health » Military Exposures » Agent Orange » Veterans' Diseases Associated with Agent ... Orange Public Health Public Health Public Health Home Military Exposures Military Exposures Home 4 Ways to Find ...

349

Agent Program Planning Information Master of Memory  

E-print Network

Agent Program Planning Information Master of Memory http://fcsagents.tamu.edu/family_life/aging/memory/mom for the exact date and time of your annual update training. Agent Planning The series was designed to be six 45

350

Spacecraft Disinfectant/Cleansing Agent Development.  

National Technical Information Service (NTIS)

The sanitation agent container, which was selected in a trade off study, employs two chambers, a rigid outer container and an inner flexible bladder. The bladder contains the sanitation agent formulation and its release is controlled by a manually operate...

M. Abbate

1977-01-01

351

Intelligent Agent Architectures: Reactive Planning Testbed  

NASA Technical Reports Server (NTRS)

An Integrated Agent Architecture (IAA) is a framework or paradigm for constructing intelligent agents. Intelligent agents are collections of sensors, computers, and effectors that interact with their environments in real time in goal-directed ways. Because of the complexity involved in designing intelligent agents, it has been found useful to approach the construction of agents with some organizing principle, theory, or paradigm that gives shape to the agent's components and structures their relationships. Given the wide variety of approaches being taken in the field, the question naturally arises: Is there a way to compare and evaluate these approaches? The purpose of the present work is to develop common benchmark tasks and evaluation metrics to which intelligent agents, including complex robotic agents, constructed using various architectural approaches can be subjected.

Rosenschein, Stanley J.; Kahn, Philip

1993-01-01

352

Agent Societies: Towards Frameworks-Based Design  

Microsoft Academic Search

We present a global methodology for the design of agent societies that takes the organisational perspective as starting point and specifies the development steps for the design and development of an agent-based system for a particular domain. So far, most agent-oriented design methodologies haven't considered the influence of the social organisation model on the functionality and objectives of the agent

Virginia Dignum; Hans Weigand; Lai Xu

2001-01-01

353

Novel oral agents for multiple sclerosis  

Microsoft Academic Search

In 1993, interferon ?-1b, the first clinically proven disease-modifying agent for multiple sclerosis, was approved, with several\\u000a comparable agents following close behind. These agents have been beneficial in reducing relapse events and MRI lesions, but\\u000a all require parenteral administration, leading some otherwise eligible patients to decline such therapies. Oral agents have\\u000a been studied for decades with mixed results, but a

Jodie M. Burton; Paul O’Connor

2007-01-01

354

Decontamination of Chemical and Biological Warfare Agents  

Microsoft Academic Search

Chemical and biological warfare agents (CBWA's) are diverse in nature; volatile acute low-molecular-weight toxic compounds, chemical warfare agents (CWA's, gaseous choking and blood agents, volatile nerve gases and blister a- gents, nonvolatile vomit agents and lacrymators), biological toxins (nonvolatile low-molecular-weight toxins, pro- teinous toxins) and microbes (bacteria, viruses, rickettsiae). In the consequence management against chemical and bio- logical terrorism, speedy

Yasuo SETO

2009-01-01

355

Participatory, embodied, multi-agent simulation  

Microsoft Academic Search

We will demonstrate the integration of a software-based multi-agent modeling platform with a participatory simulation environment and real-time control over a physical agent (robot). Both real and virtual participants will be able to act as agents in a simulation that will control a physical agent. The backbone of this demonstration is a widely used, freely available, mature modeling platform known

Paulo Blikstein; William Rand; Uri Wilensky

2006-01-01

356

A Review of Imaging Agent Development  

Microsoft Academic Search

This educational review highlights the processes, opportunities, and challenges encountered in the discovery and development\\u000a of imaging agents, mainly positron emission tomography and single-photon emission computed tomography tracers. While the development\\u000a of imaging agents parallels the drug development process, unique criteria are needed to identify opportunities for new agents.\\u000a Imaging agent development has the flexibility to pursue functional or nonfunctional

Eric D. Agdeppa; Mary E. Spilker

2009-01-01

357

Individualism and Collectivism in Trade Agents  

Microsoft Academic Search

Agent-Based Modeling can contribute to the understanding of international trade processes. Models for the effects of culture\\u000a and cultural differences on agent behavior are required for realistic agent-based simulation of international trade. This\\u000a paper makes a step toward modeling of culture in agents. The focus is one of the five dimensions of culture according to Hofstede:\\u000a individualism versus collectivism. The

Gert Jan Hofstede; Catholijn M. Jonker; Tim Verwaart

2008-01-01

358

Agent-based Modeling and Simulation  

Microsoft Academic Search

Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of autonomous, interacting agents. Computational advances have made possible a growing number of agent-based models across a variety of application domains. Applications range from modeling agent behavior in the stock market, supply chains, and consumer markets, to predicting the spread of epidemics, mitigating the threat of bio-warfare,

Charles M. Macal; Michael J. North

2009-01-01

359

Dynamic Applications Using Multi-Agents Systems  

Microsoft Academic Search

The aim of this research is to efficiently provide reusable autonomous capabilities to agent supervisors within teams, without the need to re-instantiate agents representing specific capabilities. Agent teaming\\u000a techniques have already been used to enhance the behaviour and flexibility of agent communication in the real world applications.\\u000a The theory of this concept needs to be simulated in order to generate

Mohammad Khazab; Jeffrey Tweedale; Lakhmi Jain

360

Risk-averse agents with peer pressure  

Microsoft Academic Search

This article studies the effects of peer pressure on the incentives of risk-averse agents. It defines the peer pressure function and then assumes that each agent feels peer pressure not only when his effort level is below the standard level, but also when it is above that level. It also supposes that agents are heterogeneous in terms of their productivity

Kohei Daido

2004-01-01

361

Construction and Evaluation of Animated Teachable Agents  

ERIC Educational Resources Information Center

This article describes the design decisions, technical approach, and evaluation of the animation and interface components for an agent-based system that allows learners to learn by teaching. Students learn by teaching an animated agent using a visual representation. The agent can answer questions about what she has been taught and take quizzes.…

Bodenheimer, Bobby; Williams, Betsy; Kramer, Mattie Ruth; Viswanath, Karun; Balachandran, Ramya; Belynne, Kadira; Biswas, Gautam

2009-01-01

362

Autonomous Agents with Norms Frank Dignum  

E-print Network

in an environment that is governed by some (social) norms. We divide the norms over three levels: the private level give some idea about an agent architecture incorporating the social norms based on a BDI framework. Key words: Agent society, Norms, Contracts, Speech acts 1. Introduction In the area of Multi­Agent Systems

Dignum, Frank

363

ABA: Argumentation Based Agents , L. Amgoud2  

E-print Network

ABA: Argumentation Based Agents A. Kakas1 , L. Amgoud2 , G.Kern-Isberner3 , N. Maudet4 , and P and illustrates the possibility of this type of agent design with its advantages of high-level of flexibility further to develop the concept of a fully integrated argumentation-based agent (ABA) architecture

Moraitis, Pavlos

364

Poaching and Distraction in Asynchronous Agent Activities  

Microsoft Academic Search

We investigate coordination issues in a distributed jobshop scheduling system in which agents schedule potentially contentious activities asynchronously in parallel. Agents in such a system will in general have a limited view of the global state of resources and must exchange appropriate state information with other agents in order to schedule effectively. However, even given perfect instantaneous knowledge of other

Mike H. Chia; Daniel E. Neiman; Victor R. Lesser

1998-01-01

365

Evolving software agent societies interchanging functionalities  

Microsoft Academic Search

This paper purposes a new computation model that integrates some of the most important agent technology concepts, which are based on the agent concept as the keyword from which to establish the three main pillars of the paradigm. First, a new kind of internal and external structure of the agent and of the environment where it resides based on dynamical

FRANCISCO C. CUADRADO; JOSÉ MANUEL MOLINA

2001-01-01

366

Intelligent Mobile Agents in the Military Domain  

Microsoft Academic Search

Lockheed Martin Advanced Technology Laboratories has been designing and implementing intelligent, mobile agent prototypes for various military applications since 1995. Through our experience working in the military domain, we have identified a number of agent capabilities that are common themes in many of our applications, including information push, information pull, and sentinel information monitoring. We have implemented reusable agent components

Susan McGrath; Daria Chacón; Kenneth Whitebread

2000-01-01

367

Screening of natural products for antimicrobial agents  

Microsoft Academic Search

Antimicrobial research is geared toward the discovery and development of novel chemical structures such as therapeutic antimicrobial agents. The continuing problem of development of resistance to existing antibacterial agents and the dearth of good antifungal agents motivates this effort toward innovation. Selection of possible new enzyme targets for antibiotic inhibition may be made on theoretical grounds, but it appears premature

L. Silver; K. Bostian

1990-01-01

368

Interacting Agent Based Systems Dean Petters  

E-print Network

. Emailing agents 4. Computer games 5. Robotics 6. Sociological simulations 7. Psychological simulations #12 increasingly more independence and ultimately free agents Travel and estate agents Politicians and chief it is based on a theory of consciousness it is a real application and a simulation. #12;Computer games

Bullinaria, John

369

Hydroxypyridonate chelating agents and synthesis thereof  

DOEpatents

Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided. 4 tabs.

Raymond, K.N.; Scarrow, R.C.; White, D.L.

1985-11-12

370

SIAS: a secure shopping information agent system  

Microsoft Academic Search

In this paper, we build a Shopping Information Agent System (SIAS) based on mobile agent technology. We discuss possible security attacks by malicious hosts to agents in the system, and present our solutions to prevent these attacks. We analyze the security of our solutions, and evaluate the performance overhead introduced.

Anthony H. W. Chan; Tsz Yeung Wong; Caris K. M. Wong; Michael R. Lyu

2000-01-01

371

an xml framework forAgent-based  

E-print Network

ommerceNet's eCo System initiative, launched in 1996, aims to transform the World-Wide Web into an agent. For consumers, the most obvious result of perva- sive markup will be smart shopping agents that level the playing field in their dealings with sellers. Using Internet-wide shopping directories, these agents

Glushko, Robert J.

372

Approximation of Agent Dynamics Using Reinforcement Learning  

E-print Network

a lot of attention has been the control of cooperative multi- agent systems through the use of Q-learning-based algorithms. Learning to control multiple agents for the purpose of cooperatively achieving a specified goalApproximation of Agent Dynamics Using Reinforcement Learning Kenton Kirkpatrick and John Valasek

Valasek, John

373

Knowledge Based Conversational Agents and Virtual Storytelling  

E-print Network

Knowledge Based Conversational Agents and Virtual Storytelling Paul Tarau1 and Elizabeth Figa2 1 application to voice enabled chatbots in a virtual storytelling en- vironment. The architecture integrates_agent/frame.html. Keywords: conversational agents, virtual storytelling, logic program- ming, natural language and speech

Tarau, Paul

374

TKQML: A Scripting Tool for Building Agents  

Microsoft Academic Search

Tcl\\/Tk is an attractive language for the design of intelligent agents because it allows the quick construction of prototypes and user interfaces; new scripts can easily be bound at runtime to respond to events; and execution state is encapsulated by the interpreter, which helps in agent migration. However, a system of intelligent agents must share a common language for communicat-

Ian Soboroff; Jeegar Lakhani; Timothy W. Finin; Ethan L. Miller; Charles K. Nicholas

1997-01-01

375

Using mobile agents for network performance management  

Microsoft Academic Search

Mobile agent frameworks have attracted a lot of attention in recent years, seen as counterparts of static distributed object frameworks but allowing also for object or agent mobility. A lot of research is currently being carried out trying to assess their applicability to network management and control environments. In this paper, we present our experiences of using a mobile agent

Christos Bohoris; George Pavlou; H. Cruickshank

2000-01-01

376

Selection of Luting Agents, Part 1  

Microsoft Academic Search

The clinical success of indirect restorations is dependent on multiple factors that include preparation design, mechanical forces, restorative material selection, oral hygiene, and selection of a proper luting agent. The selection of the luting agent is dependent on the spe- cific clinical situation, the type of restoration utilized and the physical, biologic, and handling properties of the luting agent. Although

Sajid A. Jivraj; Tae Hyung Kim; Terry E. Donovan

2006-01-01

377

Team Description Paper Multi-Agent Challenge  

E-print Network

~ao Pessoa - Brazil Mircea Traichioiu and Arnoud Visser Universiteit van Amsterdam, Science Park 904, 1098 XH into several subproblems, as described in [2]. The first subproblem is assigning fire-brigade agents, too many agents can be counterproductive. The fire-agents for this benchmark could choose between

Visser, Arnoud

378

Statistical Trading Using Target Oriented Trading Agent  

E-print Network

In this article we briefly present our contributions toward Trading Agent Competition (TAC); an international forum for promotion of research into the trading agent problems. Moreover, we present some strategies proposed and used in the development of our TAC Agent and resultant brief information after its participation in a real time trading environment. In the end we conclude with needed improvements and future recommendations.

Ahmed, Zeeshan

2010-01-01

379

STUDIES OF WATERBORNE AGENTS OF VIRAL GASTROENTERITIS  

EPA Science Inventory

The etiologic agent of a large outbreak of waterborne viral gastroenteritis was detected employing immune electron microscopy (IEM) and a newly developed solid phase radioimmunoassay (RIA). This agent, referred to as the Snow Mountain Agent (SMA), is 27-32 nm. in diameter, has cu...

380

Simulating human behaviors in agent societies  

Microsoft Academic Search

ABSTRACT Asincreasing,numbers ,of processors ,and ,agents ,pervade ,the human environment, societies comprising both humans and agents will emerge. Presently, it is unknown how a person might fair in such mixed societies. For the societies to operate ,effectively and efficiently, it is important for the humans and agents to recognize and understand ,each other’s behavior. This paper provides ,an initial step

Alicia Ruvinsky; Michael N. Huhns

2008-01-01

381

12 CFR 725.4 - Agent membership.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Agent membership. 725.4 Section 725...CENTRAL LIQUIDITY FACILITY § 725.4 Agent membership. (a) A central credit...group of central credit unions may become an Agent member of the Facility by (in...

2011-01-01

382

MOCHA: Modelling Organisational Change using Agents  

E-print Network

MOCHA: Modelling Organisational Change using Agents Mairi McCallum A dissertation submittedD studentship. #12;Abstract Agent-based computing is becoming a popular tool for modelling, designing and implementing distributed systems. In the engineering of multi-agent systems both the analyst and architect may

Norman, Tim

383

Agent communication pragmatics: the cognitive coherence approach  

Microsoft Academic Search

Different approaches have investigated the syntax and semantics of agent communication languages. However, these approaches have not indicated how agents should dynamically use communications. Instead of filling this prag- matics gap, most approaches have mainly focused on the structure of dialogues even though developers are more interested in agents capabilities of having useful automated conversations with respect to their goals

Vasant Honavar; Philippe Pasquier; Brahim Chaib-draa

2005-01-01

384

Agent-mediated electronic commerce: a survey  

Microsoft Academic Search

Software agents help automate a variety of tasks including those involved in buying and selling products over the Internet. This paper surveys several of these agent- mediated electronic commerce systems by describing their roles in the context of a Consumer Buying Behavior (CBB) model. The CBB model we present augments traditional marketing models with concepts from Software Agents research to

ROBERT H. GUTTMAN; ALEXANDROS G. MOUKAS; PATTIE MAES

1998-01-01

385

Programmability of Intelligent Agent Avatars (Extended Abstract)  

E-print Network

Programmability of Intelligent Agent Avatars (Extended Abstract) Zhisheng Huang a Anton Eli an approach to the programmability of intelligent agent avatars, supported by the Distributed Logic Programming language DLP. The intelligent agent avatars can be considered as one of the applications of web

Huang, Zhisheng

386

Programmability of Intelligent Agent Avatars Zhisheng Huang  

E-print Network

Programmability of Intelligent Agent Avatars Zhisheng Huang Vrije University of Amsterdam De propose an approach to the programmabil- ity of intelligent agent avatars, supported by the distributed logic programming language DLP. Intelligent agent avatars can be considered as one of the applications

Huang, Zhisheng

387

Agent-Based Software Engineering Michael Wooldridge  

E-print Network

, 1997 Abstract The technology of intelligent agents and multi-agent systems seems set to radically alter by setting out some issues and open problems for future research. 1 Introduction Intelligent agents are ninety-nine percent computer science and one percent AI. Oren Etzioni [12] Over its 40-year history

Woolridge, Mike

388

New coupled quintessence cosmology  

SciTech Connect

A component of dark energy has been recently proposed to explain the current acceleration of the Universe. Unless some unknown symmetry in Nature prevents or suppresses it, such a field may interact with the pressureless component of dark matter, giving rise to the so-called models of coupled quintessence. In this paper we propose a new cosmological scenario where radiation and baryons are conserved, while the dark energy component is decaying into cold dark matter. The dilution of cold dark matter particles, attenuated with respect to the usual a{sup -3} scaling due to the interacting process, is characterized by a positive parameter {epsilon}, whereas the dark energy satisfies the equation of state p{sub x}={omega}{rho}{sub x} ({omega}<0). We carry out a joint statistical analysis involving recent observations from type Ia supernovae, baryon acoustic oscillation peak, and cosmic microwave background shift parameter to check the observational viability of the coupled quintessence scenario here proposed.

Jesus, J. F.; Santos, R. C.; Lima, J. A. S. [Universidade de Sao Paulo, 05508-900, Sao Paulo, SP (Brazil); Alcaniz, J. S. [Observatorio Nacional, 20921-400, Rio de Janeiro-RJ (Brazil); Instituto Nacional de Pesquisas Espaciais/CRN, 59076-740, Natal-RN (Brazil)

2008-09-15

389

New coupled quintessence cosmology  

NASA Astrophysics Data System (ADS)

A component of dark energy has been recently proposed to explain the current acceleration of the Universe. Unless some unknown symmetry in Nature prevents or suppresses it, such a field may interact with the pressureless component of dark matter, giving rise to the so-called models of coupled quintessence. In this paper we propose a new cosmological scenario where radiation and baryons are conserved, while the dark energy component is decaying into cold dark matter. The dilution of cold dark matter particles, attenuated with respect to the usual a-3 scaling due to the interacting process, is characterized by a positive parameter ?, whereas the dark energy satisfies the equation of state px=??x (?<0). We carry out a joint statistical analysis involving recent observations from type Ia supernovae, baryon acoustic oscillation peak, and cosmic microwave background shift parameter to check the observational viability of the coupled quintessence scenario here proposed.

Jesus, J. F.; Santos, R. C.; Alcaniz, J. S.; Lima, J. A. S.

2008-09-01

390

Anomalous Higgs Yukawa couplings  

NASA Astrophysics Data System (ADS)

In the standard model, the Higgs boson h couples to the quarks and charged leptons according to the well-known formula (m_\\psi/v) h \\bar{\\psi}\\psi , where \\psi =\\text{quark }(q) or lepton (l) and v = 246 \\text{GeV} is its vacuum expectation value. Suppose m_\\psi is of radiative origin instead, then the effective h \\bar{\\psi} \\psi Yukawa coupling will not be exactly m_\\psi/v . We show for the first time quantitatively how this may shift the observed branching fractions of h \\to \\bar{b} b and h \\to ?+ ?- upward or downward. Thus, the precision measurements of the Higgs decay to fermions at the Large Hadron Collider, due to the resume operation in 2015, could be the key to possible new physics.

Fraser, Sean; Ma, Ernest

2014-10-01

391

Determination of degradation products of chemical warfare agents in water using hollow fibre-protected liquid-phase microextraction with in-situ derivatisation followed by gas chromatography–mass spectrometry  

Microsoft Academic Search

Hollow fibre-protected liquid-phase microextraction (HF-LPME) together with gas chromatography\\/mass spectrometry was investigated for the analysis of degradation products of chemical warfare agents in water samples. The degradation products studied were those of nerve and blister agents, and a psychotomimetic agent. Extractions were successfully performed coupled with in-situ derivatisation using a mixture of solvent and derivatising agent. The protection of the

Hoi Sim Nancy Lee; Mui Tiang Sng; Chanbasha Basheer; Hian Kee Lee

2007-01-01

392

Resistor coupled Josephson logic  

SciTech Connect

A resistor coupled Josephson logic (RCJL) family, composed of OR, AND, and 2/3 majority gates, is proposed. The RCJL family consists of multiple Josephson junctions and resistors, and employs current injected switching. OR gates have I-O isolation capability with high input sensitivity and wide operating current margin. In the AND gate, current margin as wide as the CIL AND gate and higher input sensitivity can be achieved without inductors. Experimental verification of the RCJL family operation is also described.

Sone, J.; Yoshida, T.; Abe, H.

1982-04-15

393

Minimal Coupling and Attractors  

E-print Network

The effects of minimally coupling a gravity to matter on a flat Robertson-Walker geometry are explored. Particular attention is paid to the evolution of the symplectic structure and the Liouville measure it defines. We show that the rescaling freedom introduced by choice of fiducial cell leads to a symmetry between dynamical trajectories, which together with the Liouville measure provides a natural volume weighting explanation for the generic existence of attractors.

Sloan, David

2014-01-01

394

Minimal Coupling and Attractors  

E-print Network

The effects of minimally coupling a gravity to matter on a flat Robertson-Walker geometry are explored. Particular attention is paid to the evolution of the symplectic structure and the Liouville measure it defines. We show that the rescaling freedom introduced by choice of fiducial cell leads to a symmetry between dynamical trajectories, which together with the Liouville measure provides a natural volume weighting explanation for the generic existence of attractors.

David Sloan

2014-07-15

395

Magnetic coupling device  

DOEpatents

A quick connect/disconnect coupling apparatus is provided in which a base member is engaged by a locking housing through a series of interengagement pins. The pins maintain the shaft in a locked position. Upon exposure to an appropriately positioned magnetic field, pins are removed a sufficient distance such that the shaft may be withdrawn from the locking housing. The ability to lock and unlock the connector assembly requires no additional tools or parts apart from a magnetic key.

Nance, Thomas A. (Aiken, SC)

2009-08-18

396

Gear coupling effects on rotordynamics  

E-print Network

a misalignment and the coupling's gear teeth sliding. The rotor will become more or less stable if the gear coupling forces cause the bearing load to increase or decrease, respectively. Gear couplings also cause a cross-coupled stiffness... on the rotor. This cross- coupled stifFness is generated by the internal damping, due to the gear teeth sliding, being in a rotating reference frame. If this cross-coupled stifFness is large enough it will cause the rotor to become unstable. Methods...

Clark, Robert Warren

2012-06-07

397

THREE-DIMENSIONAL MODELING OF THE DYNAMICS OF THERAPEUTIC ULTRASOUND CONTRAST AGENTS  

PubMed Central

A 3-D thick-shell contrast agent dynamics model was developed by coupling a finite volume Navier-Stokes solver and a potential boundary element method flow solver to simulate the dynamics of thick-shelled contrast agents subjected to pressure waves. The 3-D model was validated using a spherical thick-shell model validated by experimental observations. We then used this model to study shell break-up during nonspherical deformations resulting from multiple contrast agent interaction or the presence of a nearby solid wall. Our simulations indicate that the thick viscous shell resists the contrast agent from forming a re-entrant jet, as normally observed for an air bubble oscillating near a solid wall. Instead, the shell thickness varies significantly from location to location during the dynamics, and this could lead to shell break-up caused by local shell thinning and stretching. PMID:20950929

Hsiao, Chao-Tsung; Lu, Xiaozhen; Chahine, Georges

2010-01-01

398

Honey - A Novel Antidiabetic Agent  

PubMed Central

Diabetes mellitus remains a burden worldwide in spite of the availability of numerous antidiabetic drugs. Honey is a natural substance produced by bees from nectar. Several evidence-based health benefits have been ascribed to honey in the recent years. In this review article, we highlight findings which demonstrate the beneficial or potential effects of honey in the gastrointestinal tract (GIT), on the gut microbiota, in the liver, in the pancreas and how these effects could improve glycemic control and metabolic derangements. In healthy subjects or patients with impaired glucose tolerance or diabetes mellitus, various studies revealed that honey reduced blood glucose or was more tolerable than most common sugars or sweeteners. Pre-clinical studies provided more convincing evidence in support of honey as a potential antidiabetic agent than clinical studies did. The not-too-impressive clinical data could mainly be attributed to poor study designs or due to the fact that the clinical studies were preliminary. Based on the key constituents of honey, the possible mechanisms of action of antidiabetic effect of honey are proposed. The paper also highlights the potential impacts and future perspectives on the use of honey as an antidiabetic agent. It makes recommendations for further clinical studies on the potential antidiabetic effect of honey. This review provides insight on the potential use of honey, especially as a complementary agent, in the management of diabetes mellitus. Hence, it is very important to have well-designed, randomized controlled clinical trials that investigate the reproducibility (or otherwise) of these experimental data in diabetic human subjects. PMID:22811614

Erejuwa, Omotayo O.; Sulaiman, Siti A.; Wahab, Mohd S. Ab

2012-01-01

399

Method For Detecting Biological Agents  

DOEpatents

A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.

Chen, Liaohai (Los Alamos, NM); McBranch, Duncan W. (Santa Fe, NM); Wang, Hsing-Lin (Los Alamos, NM); Whitten, David G. (Santa Fe, NM)

2005-12-27

400

Agent-based health care management An Agent-based Approach to Health Care Management  

E-print Network

Agent-based health care management 1 An Agent-based Approach to Health Care Management Jun Huang1, London WC2A 3PX, UK. Abbreviated title: Agent-based health care management Complete Mailing Address. London E1 4NS UK #12;Agent-based health care management 2 Abstract The provision of medical care

Mascardi, Viviana

401

Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity—an update  

Microsoft Academic Search

Development of effective antiemetic therapy depends upon an understanding of both the antiemetic agents and the emetogenic challenges these agents are designed to address. New potential antiemetic agents should be studied in an orderly manner, proceeding from phase I to phase II open-label trials and then to randomized double-blind phase III trials comparing new agents and regimens to best standard

Steven M. Grunberg; David Osoba; Paul J. Hesketh; Richard J. Gralla; Sussanne Borjeson; Bernardo L. Rapoport; Andreas du Bois; Maurizio Tonato

2005-01-01

402

Multi-Agent Based Clustering: Towards Generic Multi-Agent Data Mining  

E-print Network

Multi-Agent Based Clustering: Towards Generic Multi-Agent Data Mining Santhana Chaimontree, Katie.Chaimontree,katie,Coenen}@liverpool.ac.uk Abstract. A framework for Multi Agent Data Mining (MADM) is de- scribed. The framework comprises a collection of agents cooperating to address given data mining tasks. The fundamental concept underpinning

Coenen, Frans

403

Multi-Agent Based Clustering: Towards Generic Multi-Agent Data Mining  

E-print Network

Multi-Agent Based Clustering: Towards Generic Multi-Agent Data Mining Santhana Chaimontree, Katie.Chaimontree, katie, Coenen}@liverpool.ac.uk Abstract. A framework for Multi Agent Data Mining (MADM) is de- scribed. The framework comprises a collection of agents cooperating to address given data mining tasks. The fundamental

Atkinson, Katie

404

Intelligent Agents An agent perceives its environment through sensors and acts on this  

E-print Network

Static vs. Dynamic - static environment doesn't change. Easier environment for agent. Does not have. semidynamic - the environment doesn't change with the passage of time but the agent's performance score doesIntelligent Agents An agent perceives its environment through sensors and acts on this environment

Imberman, Susan

405

Kendall, Malkoun, and Jiang, The Layered Agent Pattern Language 1 THE LAYERED AGENT PATTERN LANGUAGE  

E-print Network

of the following: v) mentalistic notions (beliefs, goals, plans, and intentions) vi) rationality vii) veracity, social, reactive, and pro­ active behavior that distinguishes an agent. Weak agents are assistants management. These aspects of agent behavior are summarized in Figure 1 5, 8, 10 . The agent's reasoning

Schmidt, Douglas C.

406

Adaptive battle agents: complex adaptive combat models  

NASA Astrophysics Data System (ADS)

This work explores emergent behaviour in a complex adaptive system, specifically an agent-based battlefield simulation model. We explore the changes in agent attribute sets through the use of genetic algorithms over a series of battles, with performance measured by a number of different statistics including number of casualties, number of enemy agents killed, and success rate at "capturing the flag". The agents' capabilities include (but are not limited to) maneuverability upon the battlefield, formulating, sending, receiving and acting upon messages and attacking enemy agents.

Lim, Kim L.; Mann, Isaac; Santos, Ricardo; Tobin, Brad; Berryman, Matthew J.; Abbott, Derek; Ryan, Alex

2005-12-01

407

Deaths due to Unknown Foodborne Agents  

PubMed Central

This study reviews the available evidence on unknown pathogenic agents transmitted in food and examines the methods that have been used to estimate that such agents cause 3,400 deaths per year in the United States. The estimate of deaths was derived from hospital discharge and death certificate data on deaths attributed to gastroenteritis of unknown cause. Fatal illnesses due to unknown foodborne agents do not always involve gastroenteritis, and gastroenteritis may not be accurately diagnosed or reported on hospital charts or death certificates. The death estimate consequently omitted deaths from unknown foodborne agents that do not cause gastroenteritis and likely overstated the number of deaths from agents that cause gastroenteritis. Although the number of deaths from unknown foodborne agents is uncertain, the possible economic cost of these deaths is so large that increased efforts to identify the causal agents are warranted. PMID:15498153

2004-01-01

408

Hexameric Mn(II) Dendrimer as MRI Contrast Agent.  

PubMed

A Mn(II) chelating dendrimer was prepared as a contrast agent for MRI applications. The dendrimer comprises six tyrosine-derived [Mn(EDTA)(H2 O)](2-) moieties coupled to a cyclotriphosphazene core. Variable temperature (17) O?NMR spectroscopy revealed a single water co-ligand per Mn(II) that undergoes fast water exchange (kex =(3.0±0.1)×10(8) ?s(-1) at 37?°C). The 37?°C per Mn(II) relaxivity ranged from 8.2 to 3.8?mM(-1) ?s(-1) from 0.47 to 11.7?T, and is sixfold higher on a per molecule basis. From this field dependence a rotational correlation time was estimated as 0.45(±0.02)?ns. The imaging and pharmacokinetic properties of the dendrimer were compared to clinically used [Gd(DTPA)(H2 O)](2-) in mice at 4.7?T. On first pass, the higher per ion relaxivity of the dendrimer resulted in twofold greater blood signal than for [Gd(DTPA)(H2 O)](2-) . Blood clearance was fast and elimination occurred through both the renal and hepatobiliary routes. This Mn(II) containing dendrimer represents a potential alternative to Gd-based contrast agents, especially in patients with chronic kidney disease where the use of current Gd-based agents may be contraindicated. PMID:25224391

Zhu, Jiang; Gale, Eric M; Atanasova, Iliyana; Rietz, Tyson A; Caravan, Peter

2014-10-27

409

Subcutaneous administration of anticancer agents.  

PubMed

In recent years, much has been discussed on the development of oral anticancer treatment in terms of practical aspects and convenience for the patient. Less has been devoted to the potential of subcutaneous administration as a parenteral alternative. However, recent approvals (bortezomib, omacetaxine, trastuzumab) seem to show a renewed interest in this route of administration. All anticancer agents given subcutaneously display a very high bioavailability (>80%) and are rapidly absorbed (except the monoclonal antibodies trastuzumab and alemtuzumab). Subcutaneous delivery does not impact on the rate of elimination when compared to the intravenous route (azacitidine, cladribine, bortezomib, trastuzumab). Some formulations may be self-administered in educated patients (methotrexate, cladribine) but others require hospitalization (omacetaxine). When available, comparative studies with intravenous administration showed comparable clinical issues with an advantage for subcutaneous bortezomib with regard to the occurrence of peripheral neurotoxicity. Subcutaneous formulations of trastuzumab and, in the future rituximab, may allow for ambulatory treatment and self-administration. From an economic point of view, subcutaneous formulations of monoclonal antibodies may lead to lower healthcare costs but will have to face the arrival of less expensive intravenous biologically similar agents ('biosimilars') that will reduce the cost of hospitalization. PMID:24692685

Leveque, Dominique

2014-04-01

410

Innovative Agents in Multiple Myeloma  

PubMed Central

Multiple myeloma (MM) remains an incurable cancer of the bone marrow plasma cells. However, the overall survival of patients with MM has increased dramatically within the past decade. This is due, in part, to newer agents such as immunomodulatory drugs (lenalidomide, thalidomide, and pomalidomide) and proteasome inhibitors (bortezomib, carfilzomib, MLN9708). These and several other new classes of drugs have arisen from an improved understanding of the complex environment in which genetic changes occur. Improved understanding of genetic events will enable clinicians to better stratify risk before and during therapy, tailor treatment, and test the value of personalized interventions. The ultimate goal in this incurable disease setting is to reduce the impact of cancer- or chemotherapy-related side effects. Nurses and advanced practitioners are integral to the treatment team. Thus, each should be aware of changes to the current drug landscape. Targeted drugs with sophisticated mechanisms of action are currently under investigation. Patients gain access to newer drugs within the context of clinical trials. Awareness of such trials will help accrual and determine if therapeutic benefit exists. In this article, we will describe new agents with unique and targeted mechanisms of action that have activity in patients with relapsed and/or refractory multiple myeloma. PMID:25089218

Faiman, Beth; Richards, Tiffany

2014-01-01

411

Echinocandins--new antifungal agents.  

PubMed

Over the past 10-15 years, the number of clinically available antifungal agents has increased substantially, due to rise in the number of invasive fungal infections, which are a real problem for specialists. Echinocandins are the new class of antifungal agents available for clinical use. This class comprises over 20 natural echinocandins and several semisynthetic ones. Natural echinocandins are not of clinical utility due to their toxicity and low water-solubility (which does not allow obtaining parenteral pharmaceutical forms), although they have good antifungal activity against Candida species. Consequently, semisynthetic echinocandins with minimal toxicity, good antifungal activity and high water-solubility were obtained. All echinocandins inhibit beta-1,3-glucan-synthase, an essential component of the fungal cell wall. Echinocandins exhibit potent antifungal activity against key pathogenic fungi, including Candida species, Aspergillus species and Pneumocystis carinii. The available echinocandins lack in vitro activity against Cryptococcus neoformans. The semisynthetic echinocandins have great advantages, among which low toxicity, fast antifungal activity, favorable pharmacokinetics that allow once-daily administration. The echinocandins recently available for clinical use are: caspofungin, micafungin and anidulafungin. PMID:25076727

Stan, C?t?lina Daniela; Tuchilu?, Cristina; Stan, C I

2014-01-01

412

Electric power market agent design  

NASA Astrophysics Data System (ADS)

The electric power industry in many countries has been restructured in the hope of a more economically efficient system. In the restructured system, traditional operating and planning tools based on true marginal cost do not perform well since information required is strictly confidential. For developing a new tool, it is necessary to understand offer behavior. The main objective of this study is to create a new tool for power system planning. For the purpose, this dissertation develops models for a market and market participants. A new model is developed in this work for explaining a supply-side offer curve, and several variables are introduced to characterize the curve. Demand is estimated using a neural network, and a numerical optimization process is used to determine the values of the variables that maximize the profit of the agent. The amount of data required for the optimization is chosen with the aid of nonlinear dynamics. To suggest an optimal demand-side bidding function, two optimization problems are constructed and solved for maximizing consumer satisfaction based on the properties of two different types of demands: price-based demand and must-be-served demand. Several different simulations are performed to test how an agent reacts in various situations. The offer behavior depends on locational benefit as well as the offer strategies of competitors.

Oh, Hyungseon

413

Control Architecture for Robotic Agent Command and Sensing  

NASA Technical Reports Server (NTRS)

Control Architecture for Robotic Agent Command and Sensing (CARACaS) is a recent product of a continuing effort to develop architectures for controlling either a single autonomous robotic vehicle or multiple cooperating but otherwise autonomous robotic vehicles. CARACaS is potentially applicable to diverse robotic systems that could include aircraft, spacecraft, ground vehicles, surface water vessels, and/or underwater vessels. CARACaS incudes an integral combination of three coupled agents: a dynamic planning engine, a behavior engine, and a perception engine. The perception and dynamic planning en - gines are also coupled with a memory in the form of a world model. CARACaS is intended to satisfy the need for two major capabilities essential for proper functioning of an autonomous robotic system: a capability for deterministic reaction to unanticipated occurrences and a capability for re-planning in the face of changing goals, conditions, or resources. The behavior engine incorporates the multi-agent control architecture, called CAMPOUT, described in An Architecture for Controlling Multiple Robots (NPO-30345), NASA Tech Briefs, Vol. 28, No. 11 (November 2004), page 65. CAMPOUT is used to develop behavior-composition and -coordination mechanisms. Real-time process algebra operators are used to compose a behavior network for any given mission scenario. These operators afford a capability for producing a formally correct kernel of behaviors that guarantee predictable performance. By use of a method based on multi-objective decision theory (MODT), recommendations from multiple behaviors are combined to form a set of control actions that represents their consensus. In this approach, all behaviors contribute simultaneously to the control of the robotic system in a cooperative rather than a competitive manner. This approach guarantees a solution that is good enough with respect to resolution of complex, possibly conflicting goals within the constraints of the mission to be accomplished by the vehicle(s).

Huntsberger, Terrance; Aghazarian, Hrand; Estlin, Tara; Gaines, Daniel

2008-01-01

414

Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products  

Microsoft Academic Search

This paper reports on the development of a hand-held device for on-site detection of organophosphonate nerve agent degradation products. This field-deployable analyzer relies on efficient microchip electrophoresis separation of alkyl methylphosphonic acids and their sensitive contactless conductivity detection. Miniaturized, low-powered design is coupled with promising analytical performance for separating the breakdown products of chemical warfare agents such as Soman, Sarin

Karolina-Petkovic Duran; Yonggang Zhu; Chuanpin Chen; Anthony Swallow; Robert Stewart; Pam Hoobin; Patrick Leech; Simon Ovenden

2008-01-01

415

High-sensitivity determination of the degradation products of chemical warfare agents by capillary electrophoresis–indirect UV absorbance detection  

Microsoft Academic Search

Capillary electrophoresis coupled with indirect UV absorbance detection was employed for the determination of the chemical warfare agent degradation products: methylphosphonic acid, ethyl methylphosphonate, isopropyl methylphosphonate, and pinacolyl methylphosphonate. Glutamic acid was used as a buffering agent at its isoelectric point (pH 3.22). In its zwitterionic form, glutamic acid does not act as a competing co-anion in the system, thus

Jeremy E. Melanson; Brian L.-Y. Wong; Camille A. Boulet; Charles A. Lucy

2001-01-01

416

Air-Coupled Vibrometry  

NASA Astrophysics Data System (ADS)

Sound and ultrasound in air are the products of a multitude of different processes and thus can be favorable or undesirable phenomena. Development of experimental tools for non-invasive measurements and imaging of airborne sound fields is of importance for linear and nonlinear nondestructive material testing as well as noise control in industrial or civil engineering applications. One possible solution is based on acousto-optic interaction, like light diffraction imaging. The diffraction approach usually requires a sophisticated setup with fine optical alignment barely applicable in industrial environment. This paper focuses on the application of the robust experimental tool of scanning laser vibrometry, which utilizes commercial off-the-shelf equipment. The imaging technique of air-coupled vibrometry (ACV) is based on the modulation of the optical path length by the acoustic pressure of the sound wave. The theoretical considerations focus on the analysis of acousto-optical phase modulation. The sensitivity of the ACV in detecting vibration velocity was estimated as ~1 mm/s. The ACV applications to imaging of linear airborne fields are demonstrated for leaky wave propagation and measurements of ultrasonic air-coupled transducers. For higher-intensity ultrasound, the classical nonlinear effect of the second harmonic generation was measured in air. Another nonlinear application includes a direct observation of the nonlinear air-coupled emission (NACE) from the damaged areas in solid materials. The source of the NACE is shown to be strongly localized around the damage and proposed as a nonlinear "tag" to discern and image the defects.

Döring, D.; Solodov, I.; Busse, G.

417

Optical Imaging with Dynamic Contrast Agents  

PubMed Central

Biological imaging applications often employ molecular probes or nanoparticles for enhanced contrast. However, resolution and detection are still often limited by the intrinsic heterogeneity of the Isample, which can produce high levels of background that obscure the signals of interest. In this article we describe approaches to overcome this obstacle based on the concept of dynamic contrast, a strategy for elucidating signals by the suppression or removal of background noise. Dynamic contrast mechanisms can greatly reduce the loading requirement of contrast agents, and may be especially useful for single-probe imaging. Dynamic contrast modalities are also platform-independent, and can enhance the performance of sophisticated biomedical imaging systems or simple optical microscopes alike. Dynamic contrast is performed in two stages: i) a signal modulation scheme to introduce time-dependent changes in amplitude or phase, and ii) a demodulation step for signal recovery. Optical signals can be coupled with magnetic nanoparticles, photoswitchable probes, or plasmon-resonant nanostructures for modulation by magnetomotive, photonic, or photothermal mechanisms respectively. With respect to image demodulation, many of the strategies developed for signal processing in electronics and communication technologies can also be applied toward the editing of digital images. The image processing step can be as simple as differential imaging, or may involve multiple reference points for deconvolution using cross-correlation algorithms. Periodic signals are particularly amenable to image demodulation strategies based on Fourier transform; the contrast of the demodulated signal increases with acquisition time, and modulation frequencies in the kHz range are possible. Dynamic contrast is an emerging topic with considerable room for development, both with respect to molecular or nanoscale probes for signal modulation, and also to methods for more efficient image processing and editing. PMID:21243670

Wei, Qingshan; Wei, Alexander

2011-01-01

418

Constraining Disformally Coupled Scalar Fields  

E-print Network

Light scalar fields can naturally couple disformally to matter fields. Static, non-relativistic sources do not generate a classical field profile for a disformally coupled scalar, and so such scalars are free from the constraints on the existence of fifth forces that are so restrictive for conformally coupled scalars. In this work we show that disformally coupled scalars can still be studied and constrained through their microscopic interactions with fermions and photons, both in terrestrial laboratories and from observations of stars. The strongest constraint on the coupling scale comes from mono-photon searches at the LHC and requires $M \\gtrsim 10^2 \\mbox{ GeV}$.

Philippe Brax; Clare Burrage

2014-07-07

419

Constraining Disformally Coupled Scalar Fields  

E-print Network

Light scalar fields can naturally couple disformally to matter fields. Static, non-relativistic sources do not generate a classical field profile for a disformally coupled scalar, and so such scalars are free from the constraints on the existence of fifth forces that are so restrictive for conformally coupled scalars. In this work we show that disformally coupled scalars can still be studied and constrained through their microscopic interactions with fermions and photons, both in terrestrial laboratories and from observations of stars. The strongest constraint on the coupling scale comes from mono-lepton searches at the LHC and requires $M \\gtrsim 10^2 \\mbox{ GeV}$.

Brax, Philippe

2014-01-01

420

Magnetically Coupled Calorimeters  

NASA Technical Reports Server (NTRS)

Calorimeters that utilize the temperature sensitivity of magnetism have been under development for over 20 years. They have targeted a variety of different applications that require very high resolution spectroscopy. I will describe the properties of this sensor technology that distinguish it from other low temperature detectors and emphasize the types of application to which they appear best suited. I will review what has been learned so far about the best materials, geometries, and read-out amplifiers and our understanding of the measured performance and theoretical limits. I will introduce some of the applications where magnetic calorimeters are being used and also where they are in development for future experiments. So far, most magnetic calorimeter research has concentrated on the use of paramagnets to provide temperature sensitivity; recent studies have also focused on magnetically coupled calorimeters that utilize the diamagnetic response of superconductors. I will present some of the highlights of this research, and contrast the properties of the two magnetically coupled calorimeter types.

Bandler, Simon

2011-01-01

421

Agent Reward Shaping for Alleviating Traffic Congestion  

NASA Technical Reports Server (NTRS)

Traffic congestion problems provide a unique environment to study how multi-agent systems promote desired system level behavior. What is particularly interesting in this class of problems is that no individual action is intrinsically "bad" for the system but that combinations of actions among agents lead to undesirable outcomes, As a consequence, agents need to learn how to coordinate their actions with those of other agents, rather than learn a particular set of "good" actions. This problem is ubiquitous in various traffic problems, including selecting departure times for commuters, routes for airlines, and paths for data routers. In this paper we present a multi-agent approach to two traffic problems, where far each driver, an agent selects the most suitable action using reinforcement learning. The agent rewards are based on concepts from collectives and aim to provide the agents with rewards that are both easy to learn and that if learned, lead to good system level behavior. In the first problem, we study how agents learn the best departure times of drivers in a daily commuting environment and how following those departure times alleviates congestion. In the second problem, we study how agents learn to select desirable routes to improve traffic flow and minimize delays for. all drivers.. In both sets of experiments,. agents using collective-based rewards produced near optimal performance (93-96% of optimal) whereas agents using system rewards (63-68%) barely outperformed random action selection (62-64%) and agents using local rewards (48-72%) performed worse than random in some instances.

Tumer, Kagan; Agogino, Adrian

2006-01-01

422

Surface Treatment Agents for Protection of Shorelines from Oil Spills.  

National Technical Information Service (NTIS)

A literature review and laboratory tests were conducted to provide a basis for analyzing the results of previous tests on surface treatment agents, compare agent effectiveness, and recommend agents for preliminary field tests. The surface treatment agents...

C. R. Foget, R. W. Castle, S. Naughton, J. D. Sartor, M. Miller

1984-01-01

423

13 CFR 120.955 - Agent bonds and records.  

Code of Federal Regulations, 2011 CFR

...Assistance 1 2011-01-01 2011-01-01 false Agent bonds and records. 120.955 Section 120.955...Loan Program (504) Debenture Sales and Service Agents § 120.955 Agent bonds and records. (a) Each agent...

2011-01-01

424

13 CFR 120.955 - Agent bonds and records.  

Code of Federal Regulations, 2010 CFR

...Assistance 1 2010-01-01 2010-01-01 false Agent bonds and records. 120.955 Section 120.955...Loan Program (504) Debenture Sales and Service Agents § 120.955 Agent bonds and records. (a) Each agent...

2010-01-01

425

42 CFR 434.10 - Contracts with fiscal agents.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 false Contracts with fiscal agents. 434.10 Section 434.10 Public... CONTRACTS Contracts with Fiscal Agents and Private Nonmedical Institutions § 434.10 Contracts with fiscal agents. Contracts with fiscal agents...

2011-10-01

426

Considerations in detecting CDC select agents under field conditions  

NASA Astrophysics Data System (ADS)

Surface Plasmon Resonance (SPR) has become a widely accepted technique for real-time detection of interactions between receptor molecules and ligands. Antibody may serve as receptor and can be attached to the gold surface of the SPR device, while candidate analyte fluids contact the detecting antibody. Minute, but detectable, changes in refractive indices (RI) indicate that analyte has bound to the antibody. A decade ago, an inexpensive, robust, miniature and fully integrated SPR chip, called SPREETA, was developed. University of Washington (UW) researchers subsequently developed a portable, temperature-regulated instrument, called SPIRIT, to simultaneously use eight of these three-channel SPREETA chips. A SPIRIT prototype instrument was tested in the field, coupled to a remote reporting system on a surrogate unmanned aerial vehicle (UAV). Two target protein analytes were released sequentially as aerosols with low analyte concentration during each of three flights and were successfully detected and verified. Laboratory experimentation with a more advanced SPIRIT instrument demonstrated detection of very low levels of several select biological agents that might be employed by bioterrorists. Agent detection under field-like conditions is more challenging, especially as analyte concentrations are reduced and complex matricies are introduced. Two different sample preconditioning protocols have been developed for select agents in complex matrices. Use of these preconditioning techniques has allowed laboratory detection in spiked heavy mud of Francisella tularensis at 10 3 CFU/ml, Bacillus anthracis spores at 10 3 CFU/ml, Staphylococcal enterotoxin B (SEB) at 1 ng/ml, and Vaccinia virus (a smallpox simulant) at 10 5 PFU/ml. Ongoing experiments are aimed at simultaneous detection of multiple agents in spiked heavy mud, using a multiplex preconditioning protocol.

Spinelli, Charles; Soelberg, Scott; Swanson, Nathaneal; Furlong, Clement; Baker, Paul

2008-04-01

427

Using the Model Coupling Toolkit to couple earth system models  

USGS Publications Warehouse

Continued advances in computational resources are providing the opportunity to operate more sophisticated numerical models. Additionally, there is an increasing demand for multidisciplinary studies that include interactions between different physical processes. Therefore there is a strong desire to develop coupled modeling systems that utilize existing models and allow efficient data exchange and model control. The basic system would entail model "1" running on "M" processors and model "2" running on "N" processors, with efficient exchange of model fields at predetermined synchronization intervals. Here we demonstrate two coupled systems: the coupling of the ocean circulation model Regional Ocean Modeling System (ROMS) to the surface wave model Simulating WAves Nearshore (SWAN), and the coupling of ROMS to the atmospheric model Coupled Ocean Atmosphere Prediction System (COAMPS). Both coupled systems use the Model Coupling Toolkit (MCT) as a mechanism for operation control and inter-model distributed memory transfer of model variables. In this paper we describe requirements and other options for model coupling, explain the MCT library, ROMS, SWAN and COAMPS models, methods for grid decomposition and sparse matrix interpolation, and provide an example from each coupled system. Methods presented in this paper are clearly applicable for coupling of other types of models. ?? 2008 Elsevier Ltd. All rights reserved.

Warner, J. C.; Perlin, N.; Skyllingstad, E. D.

2008-01-01

428

CXCR4-Based Imaging Agents  

PubMed Central

Chemokine receptor 4 (CXCR4)–chemokine ligand 12 (CXCL12) interactions have been shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion, tumor angiogenesis, and resistance to conventional and targeted therapies. Given its extensive involvement in cancer progression, the CXCR4–CXCL12 axis has been considered a therapeutic target. Several inhibitors blocking this signaling cascade are in phase I trials. Because CXCR4 is constitutively expressed in a wide variety of normal tissues, patient stratification and noninvasive monitoring would improve therapeutic outcome and reduce unnecessary toxicities. This review focuses on recent developments in CXCR4-based imaging agents and their potential role in the molecular diagnosis and treatment of cancer. PMID:22045705

Woodard, Lauren E.; Nimmagadda, Sridhar

2013-01-01

429

Fucoidans: Pro- or antiangiogenic agents?  

PubMed

Sulfated polysaccharides of brown algae (fucoidans) attract great attention due to their high and strongly diversified biological activity. This review summarizes recent data on the structural variability of these polysaccharides and reports their anti- and proangiogenic properties. Recent publications have revealed that fucoidans isolated from different algal species may differ considerably in the structures of their backbones and branches, in both monosaccharide composition and sulfate content. It was found that the degree of sulfation significantly influences the biological properties of fucoidans. Additionally, fucoidan action in angiogenesis is highly dependent on molecular weight: antiangiogenic activity is connected with the high-molecular weight of polysaccharide molecules, whereas the low-molecular-weight fractions may act as proangiogenic agents. The influence of other fine structural details of fucoidans on angiogenesis remains to be established. PMID:24973252

Ustyuzhanina, Nadezhda E; Bilan, Maria I; Ushakova, Natalia A; Usov, Anatolii I; Kiselevskiy, Mikhail V; Nifantiev, Nikolay E

2014-12-01

430

Agent Simulation of Chain Bankruptcy  

E-print Network

We have conducted an agent-based simulation of chain bankruptcy. The propagation of credit risk on a network, i.e., chain bankruptcy, is the key to nderstanding largesized bankruptcies. In our model, decrease of revenue by the loss of accounts payable is modeled by an interaction term, and bankruptcy is defined as a capital deficit. Model parameters were estimated using financial data for 1,077 listed Japanese firms. Simulations of chain bankruptcy on the real transaction network consisting of those 1,077 firms were made with the estimated model parameters. Given an initial bankrupt firm, a list of chain bankrupt firms was obtained. This model can be used to detect high-risk links in a transaction network, for the management of chain bankruptcy.

Ikeda, Yuichi; Souma, Wataru; Aoyama, Hideaki; Iyetomi, Hiroshi

2007-01-01

431

Major loss of junctional coupling during mitosis in early mouse embryos  

PubMed Central

Junctional coupling was assessed during the transition from the fourth to the fifth cell cycle of mouse embryogenesis by injection of the dye carboxyfluorescein and by measurement of electrical continuity between cells. Junctional coupling, which arises de novo in early 8-cell mouse embryos, subsequently becomes reduced towards the end of the cell cycle as the blastomeres enter into mitosis. Arrest of the cell cycle in metaphase by nocodazole, an inhibitor of tubulin polymerization, reveals that cell coupling becomes undetectable at mitosis. Junctional coupling then is resumed during interphase of the 16-cell stage. Nocodazole itself has no effect on junctional coupling in interphase cells, regardless of the extent of intercellular flattening, whereas taxol, a microtubule-stabilizing agent, does reduce the extent of coupling in interphase cells. PMID:2868015

1986-01-01

432

31 CFR 10.5 - Application for enrollment as an enrolled agent or enrolled retirement plan agent.  

Code of Federal Regulations, 2011 CFR

...false Application for enrollment as an enrolled agent or enrolled retirement plan agent. 10.5 Section 10.5 Money and Finance...5 Application for enrollment as an enrolled agent or enrolled retirement plan agent. Link...

2011-07-01

433

Burnout among Extension Agents in the Ohio Cooperative Extension Service.  

ERIC Educational Resources Information Center

A study examined the extent and causes of burnout among extension agents in Ohio. From the 241 extension agents working in the 88 counties of Ohio, researchers selected a random sample of 101 agents. Included in the sample were 34 agriculture agents, 33 home economics agents. Included in the sample agents were asked to complete a survey…

Igodan, O. Chris; Newcomb, L. H.

434

Does Android Dream with Intelligent Agents?  

Microsoft Academic Search

In this paper, a new agent model “specially” designed for the recent Android Google SDK is presented, where the Android mobile\\u000a phone can be considered agent software. This agent model has an approach more practical than theoretical because it uses abstractions\\u000a which allow to implement it on various systems. The appearance of Android as an open system based on Linux

Jorge Agüero; Miguel Rebollo; Carlos Carrascosa; Vicente Julián

2008-01-01

435

Moral Sentiments in Multi-agent Systems  

Microsoft Academic Search

We present a simulation of a society of agents where some of them have “moral sentiments” towards the agents that belong to\\u000a the same social group, using the Iterated Prisoner’s Dilemma as a metaphor for the social interactions. Besides the well-understood\\u000a phenomenon of short-sighted, self-interested agents performing well in the short-term but ruining their chances of such performance\\u000a in the

Ana L. C. Bazzan; Rafael H. Bordini; John Campbell

436

Bottoms up: improvisational micro-agents  

Microsoft Academic Search

This paper describes our current approach in implementing computational improvisational micro-agents, agents that perform one specific aspect of our findings from the Digital Improv Project. This approach is intended to foster bottom-up research to better understand how to build more complex agent behaviors in a theatrical improvisational setting. The Digital Improv Project is a multi-year study at the Georgia Institute

Brian Magerko; Casey Fiesler; Allan Baumer; Daniel Fuller

2010-01-01

437

Biologic agents in experimental autoimmune uveitis.  

PubMed

Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response modifiers have been investigated in both experimental and human uveitis. Monoclonal antibodies to tumor necrosis factor alpha and anti-interleukins, among others, demonstrate efficacy and are employed in the treatment of uveitis refractory to conventional immunomodulatory agents. PMID:23494482

Giuliari, Gian Paolo; Sadaka, Ama; Hinkle, David M

2014-02-01

438

Self-Motivated Behaviour of Autonomous Agents  

Microsoft Academic Search

autonomous agents. These agents can be represented by simulated animals-animats or by physical robots. The analysis of the agent's control architecture will be focused mainly on to general aspects of the self-motivated behavior. We briefly introduce basic concept of our behavior control mechanism and describe elementary phases in process of sensor-action assessment. Based on observation in ethology and biology was

M. Petrus; P. Nahodil

439

A Roadmap of Agent Research and Development  

Microsoft Academic Search

This paper provides an overview of research and development activities in the field of autonomous agents and multi-agent systems. It aims to identify key concepts and applications, and to indicate how they relate to one-another. Some historical context to the field of agent-based computing is given, and contemporary research directions are presented. Finally, a range of open issues and future

Nicholas R. Jennings; Katia P. Sycara; Michael Wooldridge

1998-01-01

440

Social Dialongue with Embodied Conversational Agents  

Microsoft Academic Search

The functions of social dialogue between people in the context of performing a task is discussed, as well as approaches to\\u000a modelling such dialogue in embodied conversational agents. A study of an agent’s use of social dialogue is presented, comparing\\u000a embodied interactions with similar interactions conducted over the phone, assessing the impact these media have on a wide\\u000a range of

Timothy Bickmore; Justine Cassell

441

The EO-1 Autonomous Science Agent Architecture  

NASA Technical Reports Server (NTRS)

An Autonomous Science Agent is currently flying onboard the Earth Observing One Spacecraft. This software enables the spacecraft to autonomously detect and respond to science events occurring on the Earth. The package includes software systems that perform science data analysis, deliberative planning, and run-time robust execution. Because of the deployment to a remote spacecraft, this Autonomous Science Agent has stringent constraints of autonomy, reliability, and limited computing resources. We describe these constraints and how they are reflected in our agent architecture.

Chien, Steve; Sherwood, Rob; Tran, Daniel; Cichy, Benjamin; Rabideau, Gregg; Castano, Rebecca; Davies, Ashley; Lee, Rachel; Mandl, Dan; Frye, Stuart; Trout, Bruce; Hengemihle, Jerry; D'Agostino, Jeff; Shulman, Seth; Ungar, Stephen; Brakke, Thomas; Boyer, Darrell; Van Gaasbeck, Jim; Greeley, Ronald; Doggett, Thomas; Baker, Victor; Dohm, James; Ip, Felipe

2004-01-01

442

The Reactive-Causal Cognitive Agent Architecture  

Microsoft Academic Search

\\u000a This study presents a general agent architecture to simulate human-like intelligence. The design philosophy behind the architecture\\u000a is driven by a combination of Maslow’s theories of needs and Dennett’s intentional notion. Furthermore, to explain motives\\u000a of intelligent agents, we adopt Alderfer’s theory of needs which revises the ideas of Maslow. Intelligent agents are considered\\u000a as entities driven by unsatisfied needs,

Ali Orhan Aydin; Mehmet Ali Orgun

443

Social Layers in Agents' Behavior Evaluation System  

Microsoft Academic Search

\\u000a Behavior evaluation is an approach to a security problem in a multi-agent system that reflects security mechanisms in a human\\u000a society. The main idea of this approach is behavior evaluation of all agents existing in society that is done autonomously\\u000a by every agent belonging to that society. All autonomous behavior evaluations have to be collected and processed in order\\u000a to

Krzysztof Cetnarowicz; Renata Cieciwa; Gabriel Rojek

2008-01-01

444

Magnetically Coupled Microcalorimeters  

NASA Technical Reports Server (NTRS)

Magnetic calorimeters have been under development for over 20 years targeting a wide variety of different applications that require very high resolution spectroscopy. They have a number of properties that distinguish them from other 10w temperature detectors. In this paper we review these properties and emphasize the types of application to which they are most suited. We will describe what has been learned about the best materials, geometries, and read-out amplifiers and our understanding of the measured performance and theoretical limits. While most magnetic calorimeter research has concentrated on the use of paramagnets to provide the temperature sensitivity, recently magnetically coupled microcalorimeters have been in development that utilize the diamagnetic response of superconductors. We will contrast some of the properties of the two different magnetic sensor types.

Bandler, S. R.; Irwin, K. D.; Kelly, D.; Nagler, P. N.; Porst, J. P.; Rotzinger, H.; Sadleir, J. E.; Seidel, G. M.; Smith, S. J.; Stevenson, T. R.

2012-01-01

445

Prediction, Coupling, and Causation  

NASA Astrophysics Data System (ADS)

Although correlation is neither necessary nor sufficient to establish causation, it remains deeply ingrained in our heuristic thinking. With increasing recognition that nonlinear dynamics are ubiquitous, and that relationships among variables will depend on system state, the use of correlation to infer causation becomes more difficult. Here we examine a criterion that identifies time series variables as causally related if they interact as part of the same dynamic system. We directly deduce the operative network of realized dynamic linkages from information embedded in time series, rather than using a proxy for the network of interactions such as diet overlap. Our approach, based on nonlinear state space reconstruction, addresses Berkeley's 301-year correlation vs. causation dilemma and identifies basic problems when the current solution, Granger causality, is applied to nonlinear ecosystems. This criterion applies even in highly nonlinear cases and provides a conceptual framework for studying coupling and catastrophic change in nature.

Sugihara, G.; May, R. M.; Ye, H.; Deyle, E. R.; Perretti, C. T.; Hsieh, C.; Munch, S. B.; Fogarty, M. J.; Stuart, S. A.; Sugihara, P.

2012-12-01

446

Strong and weak coupling of two coupled qubits  

SciTech Connect

I investigate the dynamics and power spectrum of two coupled qubits (two-level systems) under incoherent continuous pump and dissipation. New regimes of strong coupling are identified, which are due to additional paths of coherence flow in the system. Dressed states are reconstructed even in the regime of strong decoherence. The results are analytical and offer an exact description of strong coupling in the presence of pumping and decay in a nontrivial (nonlinear) system.

Valle, Elena del [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)

2010-05-15

447

Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential?  

PubMed Central

Macromolecular magnetic resonance imaging (MRI) contrast agents are increasingly being used to improve the resolution of this noninvasive diagnostic technique. All clinically-approved T1 contrast agents are small molecule chelates of gadolinium [Gd(III)] that affect bound water proton relaxivity. Both the small size and monomeric nature of these agents ultimately limits the image resolution enhancement that can be achieved for both contrast enhancement and pharmacokinetic/biodistribution reasons. The multimeric nature of macromolecules, such as polymers, dendrimers, and noncovalent complexes of small molecule agents with proteins, have been shown to significantly increase the image contrast and resolution due to their large size and ability to incorporate multiple Gd(III) chlelation sites. Also, macromolecular agents are advantageous as they have the ability to be designed to be nontoxic, hydrophilic, easily purified, aggregation-resistant, and have controllable three-dimensional macromolecular structure housing the multiple lanthanide chelation sites. For these reasons, large molecule diagnostics have the ability to significantly increase the relaxivity of water protons within the targeted tissues and thus the image resolution for many diagnostic applications. The FDA approval of a contrast agent that consists of a reversible, non-covalent coupling of a small Gd(III) chelate with serum albumin for blood pool imaging (marketed under the trade names of Vasovist and Ablivar) proved to be one of the first diagnostic agent to capitalize on these benefits from macromolecular association in humans. However, much research and development is necessary to optimize the safety of these unique agents for in vivo use and potential clinical development. To this end, recent work in the field of polymer, dendrimer, and noncovalent complex-based imaging agents are reviewed herein and the future outlook of this field is discussed. PMID:23467737

Bryson, Joshua; Reineke, Jeffrey W.; Reineke, Theresa M.

2012-01-01

448

Characterization of chemical agent transport in paints.  

PubMed

A combination of vacuum-based vapor emission measurements with a mass transport model was employed to determine the interaction of chemical warfare agents with various materials, including transport parameters of agents in paints. Accurate determination of mass transport parameters enables the simulation of the chemical agent distribution in a material for decontaminant performance modeling. The evaluation was performed with the chemical warfare agents bis(2-chloroethyl) sulfide (distilled mustard, known as the chemical warfare blister agent HD) and O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX), an organophosphate nerve agent, deposited on to two different types of polyurethane paint coatings. The results demonstrated alignment between the experimentally measured vapor emission flux and the predicted vapor flux. Mass transport modeling demonstrated rapid transport of VX into the coatings; VX penetrated through the aliphatic polyurethane-based coating (100 ?m) within approximately 107 min. By comparison, while HD was more soluble in the coatings, the penetration depth in the coatings was approximately 2× lower than VX. Applications of mass transport parameters include the ability to predict agent uptake, and subsequent long-term vapor emission or contact transfer where the agent could present exposure risks. Additionally, these parameters and model enable the ability to perform decontamination modeling to predict how decontaminants remove agent from these materials. PMID:23872337

Willis, Matthew P; Gordon, Wesley; Lalain, Teri; Mantooth, Brent

2013-09-15

449

Screening of CEST MR Contrast Agents  

PubMed Central

There has been a tremendous amount of interest in developing new MR contrast agents for cellular and molecular imaging applications such as the visualization of tumors, highlighting areas of angiogenesis, highlighting of contrast agent-labeled therapeutic stem cells, and highlighting of contrast agent-labeled drug delivery vehicles. The contrast properties of paramagnetic and super-paramagnetic relaxation-based agents have allowed MR imaging to be used as a tool for all of the above applications. However, a new class of MR contrast agents, chemical exchange saturation transfer (CEST) agents, provides additional features such as (1) the ability to highlight multiple biological events at once within an image through the distinguishability of the different CEST contrast agents, (2) the ability to toggle the contrast “off-to-on” by applying a saturation pulse, and (3) potentially providing more information about the environment surrounding the contrast agent such as the pH or concentration of metabolites. In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging. PMID:21874478

Song, Xiaolei; Chan, Kannie W.Y.; McMahon, Michael T.

2014-01-01

450

Design considerations for targeted optical contrast agents  

PubMed Central

Optical fluorescence imaging with the right combination of imaging modality and targeted contrast agents offers tremendous improvement in intraoperative imaging and clinical output (i.e., image-guided cancer surgery). Therefore, it is of paramount importance to gain an in-depth knowledge in the design of targeted contrast agents to meet clinical requirements. Currently, there are several clinically approved contrast agents available; however, none perform optimally in vivo by providing optimum sensitivity, stability, specificity, and safety for target imaging, diagnosis, and therapy. In this review, we discuss basic design considerations for targeted contrast agents in terms of optical and physicochemical properties, biological and physiological interactions, and biodistribution and targeting. PMID:23289086

Lee, Jeong Heon; Park, Gwangli; Hong, Gloria H.; Choi, Jungmun

2012-01-01

451

Collaborative Exploration with Dynamically Configurable Sensing Agents  

E-print Network

Collaborative Exploration with Dynamically Configurable Sensing Agents Darius Burschka Computer;2 Darius Burschka solution has the advantage of flexible task-dependent specification of their loca- tions

Boyer, Edmond

452

Reinforcement Learning Multi-Agent Modeling of Decision-Making Agents for the Study of Transboundary Surface Water Conflicts with Application to the Syr Darya River Basin  

NASA Astrophysics Data System (ADS)

In most economics--driven approaches to optimizing water use at the river basin scale, the system is modelled deterministically with the goal of maximizing overall benefits. However, actual operation and allocation decisions must be made under hydrologic and economic uncertainty. In addition, river basins often cross political boundaries, and different states may not be motivated to cooperate so as to maximize basin- scale benefits. Even within states, competing agents such as irrigation districts, municipal water agencies, and large industrial users may not have incentives to cooperate to realize efficiency gains identified in basin- level studies. More traditional simulation--optimization approaches assume pre-commitment by individual agents and stakeholders and unconditional compliance on each side. While this can help determine attainable gains and tradeoffs from efficient management, such hardwired policies do not account for dynamic feedback between agents themselves or between agents and their environments (e.g. due to climate change etc.). In reality however, we are dealing with an out-of-equilibrium multi-agent system, where there is neither global knowledge nor global control, but rather continuous strategic interaction between decision making agents. Based on the theory of stochastic games, we present a computational framework that allows for studying the dynamic feedback between decision--making agents themselves and an inherently uncertain environment in a spatially and temporally distributed manner. Agents with decision-making control over water allocation such as countries, irrigation districts, and municipalities are represented by reinforcement learning agents and coupled to a detailed hydrologic--economic model. This approach emphasizes learning by agents from their continuous interaction with other agents and the environment. It provides a convenient framework for the solution of the problem of dynamic decision-making in a mixed cooperative / non-cooperative environment with which different institutional setups and incentive systems can be studied so to identify reasonable ways to reach desirable, Pareto--optimal allocation outcomes. Preliminary results from an application to the Syr Darya river basin in Central Asia will be presented and discussed. The Syr Darya River is a classic example of a transboundary river basin in which basin-wide efficiency gains identified in optimization studies have not been sufficient to induce cooperative management of the river by the riparian states.

Riegels, N.; Siegfried, T.; Pereira Cardenal, S. J.; Jensen, R. A.; Bauer-Gottwein, P.

2008-12-01

453

Rapid, Cell-Based Toxicity Screen of Potentially Therapeutic Post-Transcriptional Gene Silencing Agents  

PubMed Central

Post-transcriptional gene silencing (PTGS) agents such as antisense, ribozymes and RNA interference (RNAi) have great potential as therapeutics for a variety of eye diseases including retinal and macular degenerations, glaucoma, corneal degenerations, inflammatory and viral conditions. Despite their great potential and over thirty years of academic and corporate research only a single PTGS agent is currently approved for human therapy for a single disease. Substantial challenges exist to achieving both efficacious and safe PTGS agents. Efficacy, as measured in specific target mRNA and protein knockdown, depends upon a number of complex factors including the identification of rare regions of target mRNA accessibility, cellular colocalization of the PTGS agent in sufficient concentration with the target mRNA, and stability of the PTGS agent in the target cells in which it is delivered or expressed. Safety is commonly measured by lack of cytotoxicity or other deleterious cellular responses in cells in which the PTGS agent is delivered or expressed. To relieve major bottlenecks in RNA drug discovery novel, efficient, inexpensive, and rapid tools are needed to facilitate lead identification of the most efficacious PTGS agent, rational optimization of efficacy of the lead agent, and lead agent safety determinations. We have developed a technological platform using cell culture expression systems that permits lead identification and efficacy optimization of PTGS agents against arbitrary disease target mRNAs under relatively high throughput conditions. Here, we extend the technology platform to include PTGS safety determinations in cultured human cells that are expected to represent the common cellular housekeeping microenvironment. We developed a high throughput screening (HTS) cytotoxicity assay in 96-well plate format based around the SYTOX Green dye which is excluded from healthy viable cells and becomes substantially fluorescent only after entering cells and binding to nuclear DNA. In this format we can test a number of PTGS agents for cellular toxicity relative to control elements. We also developed a HTS 96-well plate assay that allows us to assess the impact of any given PTGS agent on stimulating a variety of common cellular stress signaling pathways (e.g. CRE, SRE, AP-1, NF?B, Myc, and NFAT) that could indicate possible deleterious effects of PTGS agents either dependent or independent of base pairing complementarity with target mRNAs. To this end we exploited the secreted alkaline phosphatase (SEAP) Pathway Profiling System where the expression of the secreted reporter protein is coupled to transcriptional activation of a variety of promoter elements involved in common cell signaling pathways. We found that a variety of lead hammerhead ribozyme (hhRz) and short hairpin (shRNA) expression constructs did not exert cytotoxicity in human cells when driven by highly active RNA Pol-III promoters. We also found that most of the cell signaling pathways tested (CRE, SRE, Myc, and NFAT) did not significantly couple through upregulation to expression of the set of PTGS agents tested. AP-1 and NF?B upregulation both appear to couple to the expression of some PTGS agents which likely reflect the known properties of these pathways to be stimulated by abundant small structured RNAs. PMID:21256844

Kolniak, Tiffany A.; Sullivan, Jack M.

2011-01-01

454

Assessing groundwater policy with coupled economic-groundwater hydrologic modeling  

NASA Astrophysics Data System (ADS)

study explores groundwater management policies and the effect of modeling assumptions on the projected performance of those policies. The study compares an optimal economic allocation for groundwater use subject to streamflow constraints, achieved by a central planner with perfect foresight, with a uniform tax on groundwater use and a uniform quota on groundwater use. The policies are compared with two modeling approaches, the Optimal Control Model (OCM) and the Multi-Agent System Simulation (MASS). The economic decision models are coupled with a physically based representation of the aquifer using a calibrated MODFLOW groundwater model. The results indicate that uniformly applied policies perform poorly when simulated with more realistic, heterogeneous, myopic, and self-interested agents. In particular, the effects of the physical heterogeneity of the basin and the agents undercut the perceived benefits of policy instruments assessed with simple, single-cell groundwater modeling. This study demonstrates the results of coupling realistic hydrogeology and human behavior models to assess groundwater management policies. The Republican River Basin, which overlies a portion of the Ogallala aquifer in the High Plains of the United States, is used as a case study for this analysis.

Mulligan, Kevin B.; Brown, Casey; Yang, Yi-Chen E.; Ahlfeld, David P.

2014-03-01

455

Designing Agent Utilities for Coordinated, Scalable and Robust Multi-Agent Systems  

E-print Network

Designing Agent Utilities for Coordinated, Scalable and Robust Multi-Agent Systems Kagan Tumer NASA another, and/or enter into contracts with one an- #12;2 Kagan Tumer other [6, 8, 12, 21]. When dealing

Tumer, Kagan

456

31 CFR 10.4 - Eligibility for enrollment as enrolled agent or enrolled retirement plan agent.  

Code of Federal Regulations, 2010 CFR

...an enrolled agent to an applicant who demonstrates special competence in tax matters by written examination administered by...retirement plan agent to an applicant who demonstrates special competence in qualified retirement plan matters by written...

2010-07-01

457

Plasma conductivity at finite coupling  

E-print Network

By taking into account the full order(\\alpha'^3) type IIB string theory corrections to the supergravity action, we compute the leading finite 't Hooft coupling order(\\lambda^{-3/2}) corrections to the conductivity of strongly-coupled SU(N) {\\cal {N}}=4 supersymmetric Yang-Mills plasma in the large N limit. We find that the conductivity is enhanced by the corrections, in agreement with the trend expected from previous perturbative weak-coupling computations.

Babiker Hassanain; Martin Schvellinger

2011-08-31

458

The cross-coupled amplifier  

E-print Network

THE CROSS COUPLED AMPLIFIER A Thesis By George Clyde Robinson January 1951 THE CROSS COUPLED AMPLIFIER A Thesis GEORGE CLYDE ROBINSON JANUARY 1951 Approved as to style and content by C airma of Committee THE CROSS-COUPLED AMPLIFIER A... Thesis Submitted to the Faculty of the Agricultural and Mechanical College of Texas in Partial Fulfilment of the Requirements for the Degree of Master of Science Ma]or Sub]ect: Electrical Engineering By George Clyde Robinson January X951 TABLE...

Robinson, George Clyde

2012-06-07

459

Valorization of titanium metal wastes as tanning agent used in leather industry.  

PubMed

The development of new tanning agents and new technologies in the leather sector is required to cope with the increasingly higher environmental pressure on the current tanning materials and processes such as tanning with chromium salts. In this paper, the use of titanium wastes (cuttings) resulting from the process of obtaining highly pure titanium (ingots), for the synthesis of new tanning agent and tanning bovine hides with new tanning agent, as alternative to tanning with chromium salts are investigated. For this purpose, Ti waste and Ti-based tanning agent were characterized for metal content by inductively coupled plasma mass spectrometry (ICP-MS) and chemical analysis; the tanned leather (wet white leather) was characterized by Scanning Electron Microscope/Energy Dispersive Using X-ray (Analysis). SEM/EDX analysis for metal content; Differential scanning calorimetric (DSC), Micro-Hot-Table and standard shrinkage temperature showing a hydrothermal stability (ranged from 75.3 to 77°C) and chemical analysis showing the leather is tanned and can be processed through the subsequent mechanical operations (splitting, shaving). On the other hand, an analysis of major minor trace substances from Ti-end waste (especially vanadium content) in new tanning agent and wet white leather (not detected) and residue stream was performed and showed that leachability of vanadium is acceptable. The results obtained show that new tanning agent obtained from Ti end waste can be used for tanning bovine hides, as eco-friendly alternative for chrome tanning. PMID:24507977

Crudu, Marian; Deselnicu, Viorica; Deselnicu, Dana Corina; Albu, Luminita

2014-10-01

460

Radiation Recall with Anticancer Agents  

PubMed Central

Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As most data come from case reports, it is not possible to determine the true incidence, but to date the antineoplastic drugs for which radiation recall reactions have been most commonly reported include the anthracycline doxorubicin, the taxanes docetaxel and paclitaxel, and the antimetabolites gemcitabine and capecitabine. Radiation recall is drug-specific for any individual patient; it is not possible to predict which patients will react to which drugs, and rechallenge does not uniformly induce a reaction. There are no identifiable characteristics of drugs that cause radiation recall, and thus, it is a possibility that must be kept in mind with use of any drug after radiotherapy, including those from new drug classes. Although it is not yet possible to design treatment regimens to eliminate the risk of radiation recall, it seems likely that risks can be minimized by prolonging the interval between completion of radiotherapy and initiation of chemotherapy. PMID:21045191

Hurtig, Jane

2010-01-01

461

Erythropoietin and erythropoiesis stimulating agents.  

PubMed

Erythropoietin (EPO) is the main hormonal regulator of red blood cell production. Recombinant EPO has become the leading drug for treatment of anaemia from a variety of causes; however, it is sometimes misused in sport with the aim of improving performance and endurance. This paper presents an introductory overview of EPO, its receptor, and a variety of recombinant human EPOs/erythropoiesis stimulating agents (ESAs) available on the market (e.g. epoetins and their long acting analogs--darbepoetin alfa and continuous erythropoiesis receptor activator). Recent efforts to improve on EPO's pharmaceutical properties and to develop novel replacement products are also presented. In most cases, these efforts have emphasized a reduction in frequency of injections or complete elimination of intravenous or subcutaneous injections of the hormone (biosimilars, EPO mimetic peptides, fusion proteins, endogenous EPO gene activators and gene doping). Isoelectric focusing (IEF) combined with double immunoblotting can detect the subtle differences in glycosylation/sialylation, enabling differentiation among endogenous and recombinant EPO analogues. This method, using the highly sensitive anti-EPO monoclonal antibody AE7A5, has been accepted internationally as one of the methods for detecting misuse of ESAs in sport. PMID:22508651

Debeljak, Nataša; Sytkowski, Arthur J

2012-11-01

462

A Framework for Constructing Multi-agent Applications and Training Intelligent Agents  

Microsoft Academic Search

As agent-oriented paradigm is reaching a significant level of accep- tance by software developers, there is a lack of integrated high-level abstraction tools for the design and development of agent-based applications. In an effort to mitigate this deficiency, we introduce Agent Academy, an integrated develop- ment framework, implemented itself as a multi-agent system, that supports, in a single tool, the

Pericles A. Mitkas; Dionisis Kehagias; Andreas L. Symeonidis; Ioannis N. Athanasiadis

2003-01-01

463

Timing Agent Interactions for Efficient Agent-Based Simulation of Socio-Technical Systems  

Microsoft Academic Search

\\u000a In recent decades, agent-based modeling and simulation (ABMS) has been increasingly used as a valuable approach for design\\u000a and analysis of dynamic and emergent phenomena of large-scale, complex multi-agent systems, including socio-technical systems.\\u000a The dynamic behavior of such systems includes both the individual behavior of heterogeneous agents within the system and the\\u000a emergent behavior arising from interactions between agents within

Seung Man Lee; Amy R. Pritchett

464

Coupled Planetary Reservoirs  

NASA Astrophysics Data System (ADS)

We can look beyond the Earth, to Venus and Mars, to find opportunities to understand interactions among crust, mantle, hydrosphere, and atmosphere reservoirs. There has obviously been coupling among some of these reservoirs on other worlds, and in some cases feedback may have been in play but that is more difficult to demonstrate. The massive CO2 atmosphere of Venus has likely fluctuated significantly over its history due to exchange with other reservoirs, with attendant greenhouse effects strongly modulating surface temperature. Additionally, release of H2O and SO2 from large-scale magmatic events may have led to significant surface temperature increases, ?T0, and the details depend on the competition between IR radiation warming and planetary albedo increase due to cloud formation. Diffusion of ? T0 into the shallow crust may be responsible for the rapid global formation of compressional wrinkle ridges following widespread volcanic resurfacing [Solomon et al., 1999]. Diffusion of ?T0 into the venusian upper mantle could have increased the rate of partial melting. The accompanying increase in volatile release to the atmosphere could set up a positive feedback because of increased greenhouse warming diffusing into the planet's interior [Phillips et al., 2001, Venus]. Another outcome of deep penetration of a greenhouse-induced positive ?T0 is the lowering of mantle viscosity and an accompanying decrease in convective stress, which could shut down an exisiting lithospheric recycling regime [Lenardic et al., 2008]. Mars offers a rich set of possibilities for coupling between reservoirs [Jakosky and Phillips, 2001]. Magmatism at the massive Tharsis volcanic complex possibly induced episodic climate changes in the latter part of the Noachian era (~3.6-4.2 Ga). This could have led to clement conditions, forming valley networks that follow a regional slope caused partly by the mass load of Tharsis itself [Phillips et al., 2001, Mars]. Earlier in the Noachian, lithospheric recycling may have ended as surface temperatures warmed due to planetary outgassing, leading to the Lenardic catastrophe. Outer core convection may have been muted as the mantle heated up, shutting down the martian dynamo [Nimmo and Stevenson, 2000]. In turn, much of the extant atmosphere could have been lost to space, no longer protected from the solar wind by a global magnetic field.

Phillips, R. J.

2008-12-01

465

Polymeric coupling agents for enhancing the adhesion of epoxy to steel-II  

SciTech Connect

Steel is one of the most versatile materials known to mankind. It is used in a variety of applications. In many of these applications, it is exposed to the atmosphere, leading to rust formation, which weakens structures made using steel. Hence, protection is important. The popular methods to prevent corrosion are painting, galvanizing, electroplating etc. The widely used Chrome etching process is very effective in corrosion inhibition as well as in hardening the steel. But, Chromium and its compounds are highly placed among the toxic chemicals listed under pollution prevention initiatives of the EPA. Hence, it was decided to find alternatives to this process.

Vaidesswaran, K.; Bell, J.P. [Inst. of Materials Science, Storrs, CT (United States); Nikles, D.E. [Center for Materials for Information Technology, Tuscaloosa, AL (United States)

1996-12-31

466

Synthesis of antihypertensive agents via coupling reaction of Benzothiazepinone and 1,4-dihydropyridine derivatives  

Microsoft Academic Search

The synthesis of3a, 3b, 7a and7b from Benzothiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone and 1,4-dihydropyridine derivatives\\u000a were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothiazepinone\\u000a and 1,4-dihydropyridine derivatives.

Won-Hun Ham; Jae-Gwon Yang; Tae-Gyun Lim; Yun-Ho Jung; Yun-Sung Chung

1994-01-01

467

A localized crystallization to hierarchical ZSM-5 microspheres aided by silane coupling agent.  

PubMed

Hierarchical ZSM-5 microspheres were synthesized from a ZSM-5 synthesis solution with the addition of 3-aminopropyltriethoxysilane (APTES). The time dependent revolution of structure and morphology was investigated by XRD, SEM, TEM, N(2) adsorption-desorption, and (29)Si MAS NMR techniques. The results indicated that amorphous aluminosilicate microspheres with diameter of 8 ?m were obtained at the initial stage of the synthesis. With the crystallization going on, the amorphous aluminosilicates gradually crystallized to ZSM-5 structure while preserving the spherical morphology. For the first time, a novel phenomenon of localized crystallization of ZSM-5 has been demonstrated in a conventional zeolitic synthesis solution aided by APTES. Moreover, after removing the amorphous silicic residues, the hierarchical ZSM-5 microspheres showed excellent catalytic properties in benzylation of benzene and catalytic cracking of polypropene. PMID:23321427

Xiao, Qiang; Yao, Qiongsi; Zhuang, Jin; Liu, Gang; Zhong, Yijun; Zhu, Weidong

2013-03-15

468

Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents  

Microsoft Academic Search

Summary  Our strategy is to increase drug accumulation in target tumour cells using specific “vectors” tailored to neoplastic tissue\\u000a characteristics, which ideally are not found in healthy tissues. The aim of this work was to use 2-fluoro-2-deoxyglucose (FDG)\\u000a as a drug carrier, in view of its well-known accumulation by most primary and disseminated human tumours. We had previously\\u000a selected two FDG-cytotoxic

Elisabeth Miot-Noirault; Bastien Reux; Eric Debiton; Jean-Claude Madelmont; Jean-Michel Chezal; Pascal Coudert; Valérie Weber

2011-01-01

469

Bipolar thiols as coupling agent for the grafting of conducting polymers  

NASA Astrophysics Data System (ADS)

The deposition of conducting polymers onto metallic substrates (Pt,Ti) is performed after a chemical pretreatment of the surface substrate using aliphatic (CH3-(CH2)n-SH n=0 to 10) and bipolar thiols (?-(CH2)nSH, n=0,1,2,3). The pretreatment impedes the metal oxidation and improves the polymer film adhesion with aromatic thiols. Moreover, this procedure leads to dense, longer conjugated polymers with fewer defects.

Lang, P.; Mekhalif, Z.; Garnier, F.; Regis, A.

1996-01-01

470

Marriage Equality for Same-Sex Couples: Counseling Psychologists as Social Change Agents  

ERIC Educational Resources Information Center

The denial of civil marriage rights is a specific example of minority stress that can negatively affect the psychosocial well-being of self-identified lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals in same-sex partnerships, their families, and their allies. Counseling psychologists have an important role in addressing the…

Rostosky, Sharon S.; Riggle, Ellen D. B.

2011-01-01

471

Effects of mixed silane coupling agent on porcelain tooth material and various dental alloys.  

PubMed

Mixed salines, 3-methacryloxypropylsilytriisocyanate and 3-mercaptopropyltrimethoxysilane, were used as primers for adhesion of poly(methyl methacrylate) to porcelain teeth, precious alloys and nonprecious alloys. After thermocycle testing, the mean bond strength of the resin to porcelain, silver alloys and stainless steel were excellent. The fracture patterns of porcelain teeth after thermocycling followed by adherent testing were similar to those of specimens subjected to 48-hour water immersion at 37 degrees C. Two specimens failed cohesively in the porcelain and the other specimens failed in the resin. The mixed primer had no effect on cobalt-chromium alloy specimens. PMID:8940552

Umemoto, K; Kurata, S

1995-12-01

472

Coupling constant of microcavity waveguides based on coupled mode theory  

Microsoft Academic Search

We analyze the microcavity waveguides and derive the coupling constant based on the coupled mode theory. The formula contains only two parameters with clear physical meanings, the quality factor of the cavity modes and the phase shift that the lightwave acquires when tunnelling between two cavities. It provides an easy way to express and modulate the properties of the waveguides.

Xu-Sheng Lin; Jun-Hu Yan

2009-01-01

473

Session on coupled atmospheric/chemistry coupled models  

NASA Technical Reports Server (NTRS)

The session on coupled atmospheric/chemistry coupled models is reviewed. Current model limitations, current issues and critical unknowns, and modeling activity are addressed. Specific recommendations and experimental strategies on the following are given: multiscale surface layer - planetary boundary layer - chemical flux measurements; Eulerian budget study; and Langrangian experiment. Nonprecipitating cloud studies, organized convective systems, and aerosols - heterogenous chemistry are also discussed.

Thompson, Anne

1993-01-01

474

Mobility platform coupling device and method for coupling mobility platforms  

DOEpatents

A coupling device for connecting a first mobility platform to a second mobility platform in tandem. An example mobility platform is a robot. The coupling device has a loose link mode for normal steering conditions and a locking position, tight link mode for navigation across difficult terrain and across obstacles, for traversing chasms, and for navigating with a reduced footprint in tight steering conditions.

Shirey, David L. (Albuquerque, NM); Hayward, David R. (Albuquerque, NM); Buttz, James H. (Albuquerque, NM)

2002-01-01

475

Cardiac image segmentation for contrast agent videodensitometry  

Microsoft Academic Search

Indicator dilution techniques are widely used in the intensive care unit and operating room for cardiac parameter measurements. However, the invasiveness of current techniques represents a limitation for their clinical use. The development of stable ultrasound contrast agents allows new applications of the indicator dilution method. Ultrasound contrast agent dilutions permit an echographic noninvasive measurement of cardiac output, ejection fraction,

Massimo Mischi; Antonius A. C. M. Kalker; Henricus H. M. Korsten

2005-01-01

476

MOBILE AGENT TECHNOLOGY: CURRENT TRENDS AND PERSPECTIVES  

Microsoft Academic Search

New technologies are required to face new scenarios due to the fast spread of the Internet. The paper s urveys the c urrent t rends of the e merging mobile agent technology. In a high-connected world, agents are the active entities, which roam across network nodes on behalf of their senders. We show some applications that can take advantages from

G. Cabri; L. Leonardi; F. Zambonelli

477

Go! for multi-threaded deliberative agents  

Microsoft Academic Search

Go! is a multi-paradigm programming language that is ori- ented to the needs of programming secure, production quality, agent based applications. It is multi-threaded, strongly typed and higher or- der (in the functional programming sense). It has relation, function and action procedure definitions. Threads execute action procedures, calling functions and querying relations as need be. Threads in dier- ent agents

Keith L. Clark; Francis G. McCabe

2003-01-01

478

Verification within the KARO Agent Theory  

Microsoft Academic Search

Summary. This chapter proposes two new methods for realising automated reason- ing within agent-based systems. We concentrate on a core of the KARO framework, which is a specication framework for modelling intelligent agent behaviour. We discuss the advantages of each approach and suggest ways of extending each variant to cover more of the KARO framework.

Ullrich Hustadt; Clare Dixon; Renate A. Schmidt; Michael Fisher; John-Jules Charles Meyer; Wiebe Van Der Hoek

2000-01-01

479

The Design of Motivational Agents and Avatars  

ERIC Educational Resources Information Center

While the addition of an anthropomorphic interface agent to a learning system generally has little direct impact on learning, it potentially has a huge impact on learner motivation. As such agents become increasingly ubiquitous on the Internet, in virtual worlds, and as interfaces for learning and gaming systems, it is important to design them to…

Baylor, Amy L.

2011-01-01

480

Mobile Agents with Java: The Aglet API  

Microsoft Academic Search

Java, the language that changed the Web overnight, offers some unique capabilities that are fueling the development of mobile agent systems. In this article we will show what exactly it is that makes Java such a powerful tool for mobile agent development. We will also draw attention to some shortcomings in Java language systems that have implications for the conceptual

Danny B. Lange; Mitsuru Oshima

1998-01-01

481

Normative KGP Agents Fariba Sadri1  

E-print Network

to as artificial societies [28]. Such an implementation seeks to apply social agents in practical applications where the formation of open societies [4] are envisaged to be regulated by norms. The notion of a norm is important here in that member agents of a society [34] must have the capability to reason with norms

Toni, Francesca

482

Biological agents: Weapons of warfare and bioterrorism  

Microsoft Academic Search

The use of microorganisms as agents of biological warfare is considered inevitable for several reasons, including ease of production and dispersion, delayed onset, ability to cause high rates of morbidity and mortality, and difficulty in diagnosis. Biological agents that have been identified as posing the greatest threat are variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin

Larry A. Broussard

2001-01-01

483

Ultrasound Contrast Agents in Ischemic Stroke  

Microsoft Academic Search

The general indication for the use of ultrasound contrast agents in neurosonologic applications is an insufficient signal-to-noise ratio when investigating the cerebral macro- and microcirculation. Clinical problems that are often encountered in native sonography are ‘no flow, slow flow and low flow’ phenomena. In these cases, ultrasound contrast agents are used to differentiate between vessel occlusion and insufficient insonation conditions,

Günter Seidel; Stephen Meairs

2009-01-01

484

Enhancing Mobile Agents with Electronic Commerce Capabilities  

E-print Network

topics of the today's research work. Mobile agents are no longer a theoretical issue as different and process migration. In the research field of networking and distributed systems, mobile agents are an exten architectures for their implementations have been proposed. Research institutes as well as companies develop

485

A Language for Interactive Cooperative Agents  

Microsoft Academic Search

Cooperative behaviour of agents within highly dynamic and nonde- terministic domains is an active eld of research. In particular estab- lishing highly responsive teamwork, where agents are able to react on dynamic changes in the environment while facing unreliable communica- tion and sensory noise, is an open problem. Moreover, modelling such responsive, cooperative behaviour is dicult. In this work, we

Hendrik Skubch; Michael Wagner; Roland Reichle

486

Behavior selection architecture for tangible agent  

Microsoft Academic Search

Tangible agent (TA) is a new medium that communicates the senses of sight, hearing, touch, smell, and taste of human to computer. Intelligent behavior is a key property to realize the agent because it must interact with human to grasp all the information. We have adopted a behavior-based approach for high-level behaviors such as navigation of office, conversation with human,

Kyung-Joong Kim; Sung-Bae Cho; Sang-Rok Oh

2003-01-01

487

Posted 3/22/13 PURCHASING AGENT  

E-print Network

Comparison, Food Service/Food Wholesale experience · Proficient computer skills in MS Word, Excel and OutlookPosted 3/22/13 PURCHASING AGENT Our Chicago-based Food Service Company is seeking an experienced Purchasing Agent who will be responsible for the following: · Buying a large range of food items, including

Heller, Barbara

488

Temporal Logics for Representing Agent Communication Protocols  

Microsoft Academic Search

Abstract. This paper explores the use of temporal logics in the con- text of communication,protocols for multiagent systems. We concentrate on frameworks where protocols are used to specify the conventions of social interaction, rather than making reference to the mental states of agents. Model checking can be used to check the conformance of a given dialogue between agents to a

Ulle Endriss

2006-01-01

489

AGENT-BASED MODELS Nigel Gilbert  

E-print Network

becoming popular. This short book explains what agent-based modeling is. It also warns of some dangers and in print. Agent-based simulation has become increasingly popular as a modeling approach in the social. A network of nodes and edges can model a set of friendships. Even an ordinary language description

Tesfatsion, Leigh

490

Guarantees for Autonomy in Cognitive Agent Architecture  

Microsoft Academic Search

The paper analyses which features of an agent architecture determine its Autonomy. I claim that Autonomy is a relational concept. First, Autonomy from environment (stimuli) is analysed, and the notion of Cognitive Reactivity is introduced to show how the cognitive architecture of the agent guarantees Stimulus-Autonomy and deals with the Descartes problem relative to the external causes of behaviour. Second,

Cristiano Castelfranchi

1994-01-01

491

Using Intelligent Agents in Wireless Sensor Networks  

Microsoft Academic Search

Intelligent agents can be used as a valuable asset when deployed within a wireless sensor network. Wireless sensor networks have a number of limitations, which need to be addressed before creating successful agents. These limitations include issues with energy conservation, mitigating resource limitations and wireless link availability to name a few. Middleware software can be used to overcome these shortcomings

Andrew J Younge

492

Agent Assistance: From Problem Solving to Music  

Microsoft Academic Search

We report on our research on agents that act and behave in a web learning environment. This research is part of a general approach to agents acting and behaving in virtual environments where they are involved in providing information, performing transactions, demonstrating products and, more generally, assisting users or visitors of the web environment in doing what they want or

493

Understanding socially intelligent agents - a multilayered phenomenon  

Microsoft Academic Search

The ultimate purpose with socially intelligent agent (SIA) technology is not to simulate social intelligence per se, but to let an agent give an impression of social intelligence. Such user-centred SIA technology, must consider the everyday knowledge and expectations by which users make sense of real, fictive, or artificial social beings. This folk-theoretical understanding of other social beings involves several,

Per Persson; Jarmo Laaksolahti; Peter Lönnqvist

2001-01-01

494

The Evolution of Communication in Adaptive Agents  

Microsoft Academic Search

This paper explores how communication can be understood as an adaptation byagents to their environment. We model agents as recurrent neural networks. Afterarguing against systems which use discrete symbols to evolve communication, wesupply our agents with a number of continuous communications channels. Theagents use these channels to initiate real-valued signals which propagate throughthe environment, decaying over distance, perhaps being perturbed

Gregory M. Saunders; Jordan B. Pollack