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1

Comparative genetico-mathematic analysis of essential hypertension and coronary heart disease mode of inheritance: a study using direct methods testing.  

PubMed

Essential hypertension (EH) and coronary heart disease (CHD) very often exhibit familial recurrence pattern, which are estimated in the Bulgarian population at 63.11% for EH and at 48.90% for CHD. The author made comparative genetico-mathematical analysis of the inheritance patterns of the two diseases. Examining the pedigrees from a large number of families two data sets were formed and analyzed separately: a subgroup of families of probands with phenotypically unaffected parents, in which the genealogical pattern was most often consistent with a recessive model of inheritance and a subgroup of families of probands with one or both parents affected, in which the pedigree analysis resembled that of a disease with a monogenic dominant model of inheritance. The segregation coefficients obtained in the subgroup of families with two healthy parents most often varied from 0.298 to 0.362--results that consistently reject the hypothesis of recessive inheritance; the respective coefficients obtained by the same direct methods in the subgroup of families with one or both parents affected showed values from 0.279 to 0.468--findings rejecting the hypothesis of dominant model of inheritance. The author pointed out the identical relationships exhibited by genetico-mathematical testing of EH and CHD, a fact demonstrating the significant genetic proximity between the two diseases. Conclusions are made about the complex and specific relationships between genetic and environmental risk factors in the two diseases. PMID:9141794

Karnolski, I

1997-01-01

2

Un probleme social: le conflit des genres en dano-norvegien (A Social Problem: Gender Conflict in Dano-Norwegian)  

ERIC Educational Resources Information Center

This article describes the co-existence in Dano-Norwegian of two different systems of grammatical gender, one belonging to Dano-Norwegian, and the other to Norwegian. The conflict is described as social, cultural and political in nature as well as linguistic. (Text is in French.) (AM)

Flydal, Leiv

1975-01-01

3

Brunet Estarelles, Pere J., y Glvez Capell, Francisco, J. (1995). Estructura urbana y movilidad: anlisis del trfico inducido por el Campus de la Universitat de les Illes  

E-print Network

Brunet Estarelles, Pere J., y Gálvez Capellá, Francisco, J. (1995). Estructura urbana y movilidad Nacional de Geografía. Salamanca. Pp: 322-325. ESTRUCTURA URBANA Y MOVILIDAD. ANALISIS DEL TRAFICO INDUCIDO). Estructura urbana y movilidad: análisis del tráfico inducido por el Campus de la Universitat de les Illes

Oro, Daniel

4

RESPONSABILIDADE CIVIL OBJETIVA DO ESTADO POR DANOS DECORRENTES DA M CONSERVAO DAS VIAS PBLICAS 1  

Microsoft Academic Search

RESUMO: O presente artigo visa demonstrar que Responsabil idade do Estado a conservao das vias pblicas e, se a Administrao Pblica no cumprir com a prestao dos servios pblicos, responder pelos danos que decor rerem de sua omisso objetivamente, como prev o 6 do Art. 37 da Constituio Federa l. Ter as vias pblicas conservadas garante a segurana

Patrcia Bispo Zanusso

5

AMLIORATION DES PLANTES Avance en el mejoramiento genetico del trigo en  

E-print Network

periodo invierno-primavera de 1982-83 y de 1983-84, se evaluaron 81 variedades de trigo (Triticum aestivum breeding in Mexico. During the winter-spring of 1982-83 and 1983-84, 81 wheat varieties (Triticum aestivum: Triticum aestivum, Mexican wheat program, wheat yield in Mexico, yield components, grain filling rate

Boyer, Edmond

6

Pauli measurements are universal Vincent Danos (CNRS, Univ Paris 7)  

E-print Network

as an important theoretical quantum computing model, it is only recently that some of its measurement patterns a potentially useful simplification of the underlying hardware needed to realise the feedforward mechanism. We is irrelevant to the result of a computation. The instruction M i stands for a one qubit measurement applied

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7

7

Valutazione dell'impatto della farmacogenetica in ambito di Sanit Pubblica. Analisi del polimorfismo genetico dell'enzima CYP2D6 metabolizzante xenobiotici.  

E-print Network

??Pharmacogenetic testing provides an outstanding opportunity to improve prescribing safety and efficacy. In Public health policy pharmacogenetics is relevant for personalized therapy and to maximize (more)

Riccardi, Laura Natalia and#60;1982and#62

2011-01-01

8

Participacin local de la va L-arginina-xido ntrico-GMPc en el efecto antinociceptivo inducido por parecoxib  

Microsoft Academic Search

Summary Objective: The present study was undertaken to determine whether the local antinociceptive activity of parecoxib is mediated, at least in part, through the L-arginine-NO-cGMP pathway using the pain-induced functional impairment model in the rat. Material and methods: A comparative and experimental study was designed using 48 female Wistar rats, weighing between 180 and 200 g. Pain was induced through

Zoraida Irene Martnez-Quiroz; Francisco Javier Lpez-Muoz; Uriah Medardo Guevara-Lpez

2005-01-01

9

Actividad antioxidante de la melatonina sobre el hgado graso inducido por etionina en ratones# Antioxidant activity of melatonin on fatty liver induced by ethionine in mice  

Microsoft Academic Search

SUMMARY The aim of this study was to determine the antioxidant activity of melatonin in female mice with ethionine-induced hepatic oxidative stress (HOS), and the effect of this hormone on the gluthatione peroxidase enzyme antioxidant activity. Twenty adult female NMRI mice were given intraperitoneally 3 mg\\/kg melatonin in 1% ethanol daily for 15 days, and 1% ethanol to the control

SM Ferraro; A Lpez-Ortega

10

F i n e s t r a s u l f u t u r o Fra gli enti di ricerca multi-disciplinari,  

E-print Network

il posto in essa occupato dall'umanità . Cio' che sprona gli scienziati, è lo spirito di ricerca cosi'arte edilizia, ad inventare la scrittura, a sfruttare l'elettricità per il progresso della tecnologia materiali ed a decifrare il codice genetico impresso in tutte le piante ed animali esistenti sul globo

11

Caso Chernobyl: sus repercusiones en el sistema Internacional sobre responsabilidad civil por danos nucleares. (Chernobyl case: its repercussions on the International System on Civil Liability for Nuclear Damages).  

National Technical Information Service (NTIS)

With the discovery of the Nuclear Energy the world has been development her life the present investigation is based in the accident of the one of the most important Nuclear Power Plant in the world, situated in the Union of Socialist Sovietic Republics. T...

J. L. Gonzalez Guadarrama

1992-01-01

12

EFECTOS FARMACOLGICOS SOBRE EL SISTEMA NERVIOSO CENTRAL INDUCIDOS POR CUMARINA, AISLADA DE Hygrophila tyttha LEONARD PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM Hygrophila tyttha LEONARD  

Microsoft Academic Search

This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: \\

Sandra Y. ARIZA; Diana C. RUEDA; Edgar L. LINARES; Mario F. GUERRERO

13

Estudio de sntesis y acoplamiento molecular inducido de nuevos derivados N-{4-[4-(1H-indol-2-carbonil)-1-piperazinil]fenilarilamidas : hetero bis-ligandos con potencial actividad serotoninrgica 5-HT1A en la bsqueda de nuevas molculas antidepresivas .  

E-print Network

??Estudios de funcionalizacin del 1H-indol-2-acido carboxlico, condujeron a la sntesis de una familia de compuestos N-{4-[4-(1H-Indol-2-carbonil)-1-piperazinil]-fenil}- arilamidas 4(a-h) con potencial actividad serotoninrgica en el sistema (more)

Andrades Lagos, Juan Andrs

2013-01-01

14

UNIVERSIDAD AUTNOMA DE MADRID CENTRO DE MICRO-ANLISIS DE MATERIALES  

E-print Network

.ynsa@uam.es CMAM OFERTA DE PROYECTO FIN DE CARRERA (INGENIERO DE TELECOMUNICACI?N) DESARROLLO DE SISTEMAS DE deberá integrar estos parámetros en un software que permita el control simultáneo del barrido durante las medidas. Puesto que el movimiento del haz inducido por el deflector magnético puede combinarse con un

Autonoma de Madrid, Universidad

15

Evaluacin econmica de polticas educativas: Una ilustracin con la Ley General de la Educacin de 1970  

Microsoft Academic Search

En este trabajo se trata de evaluar el impacto econmico de las polticas educativas tomando como ilustracin los cambios inducidos por la promulgacin y posterior implementacin de la Ley General de Educacin de 1970. Basndose en la interpretacin de la estimacin de Variables Instrumentales sugerida en Imbens y Angrist (1994) se estima el impacto econmico de la reforma sobre aquellos

Mara Arrazola; Jos de Hevia

2003-01-01

16

Anlise Estrutural de Rotores de Turbinas Hidrulicas para Estudo da Incidncia de Trincas e Desempenho Vida de Fadiga  

Microsoft Academic Search

Resumo - Um rotor de turbina hidrulica projetado para vida infinita fadiga. Porm, em funo de necessidades de manu- teno e de reparos, que com freqncia so realizados por processos severos, como a soldagem por arco eltrico, pode-se inserir dano a estes componentes, reduzindo a vida fadiga. O acompanhamento dos nveis de tenses residuais indicam o grau

C. G. Filippin; A. T. de Lira

17

ANEXO DA RESOLUO NORMATIVA N. 19/CUn/2012. TERMO DE ADESO N. ________/____/UFSC/20___ AO PROGRAMA DE SERVIO  

E-print Network

responderá civil e penalmente pelos danos causados ao patrimônio da UFSC que esteja sob sua guarda ou responsabilidade, devendo restituir os bens que lhe forem entregues nas mesmas condições que os recebeu. 5.3.O

Floeter, Sergio Ricardo

18

ADMINISTRAO Ano Ttulo Autor(a)  

E-print Network

CONSTRU??O CIVIL ALINE SIEBERT CORBETTA 2004 PLANO DE MARKETING DA FÁBRICA NANA CARANA AMANDA BORGES BARROS A SUA RESPONSABILIDADE INERENTE ? OCORR?NCIA DE DANOS AMBIENTAIS ANABEL PEREIRA 2004 A FORMA??O DE

Floeter, Sergio Ricardo

19

Experimental Investigation of Jet Mixing of a Co-Flow Jet Airfoil  

E-print Network

Experimental Investigation of Jet Mixing of a Co-Flow Jet Airfoil B. P. E. Dano, D. Kirk and G The jet mixing of a co-flow jet (CFJ) airfoil is investigated to understand the mechanism of lift and aerodynamic forces measurements are used to reveal the insight of the CFJ airfoil mixing process. At low Ao

Zha, Gecheng

20

Under consideration for publication in Math. Struct. in Comp. Science Equilibrium and Termination II: the case of  

E-print Network

the complex distributed system par excellence, namely the combinatorial processes at work in biomolecular net and Laneve(2004); Danos et al.(2007); Faeder et al.(2009)). Rule-based methods in particular introduce modeling domain, is not just to make the modeling more agile and far-reaching. As has been long recognised

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7

21

Avaliao da presso arterial de crianas e adolescentes aten- didos em Clnica Odontopeditrica Evaluation of the blood pressure of children and adolescents at- tending at the Odontopediatric Clinic  

Microsoft Academic Search

Key-words A hipertenso arterial sistmica uma doena que se mantm silenciosa, sem manifestao de qualquer sinal ou sintoma, antes de provocar srios danos a rgos nobres como corao, rins e crebro. Para sua deteco precoce necessria aferio peridica das presses arteriais sistlica e diastlica desde os primrdios da infncia. Sem dvida, porm, em situaes que gerem tenso ou

Cristiana Abrantes; Fonte Neves; Geraldo Bosco; Lindoso Couto; Ktia Virginia; Guerra Botelho; Mrcia Maria Vendenciano Barbosa; Renata Patrcia de Freitas Soares; Jouse Bezerra Cavalcanti; Gineuda Maria do Prado Silva

22

An RNAseq Protocol to Identify mRNA Expression Changes in Mouse Diaphyseal Bone: Applications in  

E-print Network

An RNAseq Protocol to Identify mRNA Expression Changes in Mouse Diaphyseal Bone: Applications in Mice with Bone Property Altering Lrp5 Mutations Ugur M Ayturk,1,2 Christina M Jacobsen,1,3 Danos C) significantly decrease or increase bone mass, respectively. These human skeletal phenotypes have been

23

ALTERNATIVAS REDUCIR VOLUMEN TOTAL  

E-print Network

, Ródano) · FOMENTAR, A NIVEL DE LEY,BUENAS PRÁCTICAS DE GESTI?N DEL AGUA #12;GESTI?N INTEGRADA DEL AGUA Reconocimiento de todas las opciones para cubrir las necesidades de agua · REDUCIR LA DEMANDA - Políticas de) - "Cultivo" de agua. Generación distribuída - Gestión conjunta - Agua superficial y subterránea - Agua y

Politècnica de Catalunya, Universitat

24

A protocol for storage and long-distance shipment of Mediterranean fruit fly (Diptera: Tephritidae) eggs. 1. Effect of temperature, embryo age , and storage time on survival and quality  

SciTech Connect

The operational use of Mediterranean fruit fly (medfly) Ceratitis capitata (Wiedemann), genetic sexing strains in Sterile Insect Technique applications can be maximized by developing methods for effective shipment of eggs. This would enable a central production facility to maintain the relevant mother stocks and large colonies to supply eggs to satellite centers that would mass produce only males for irradiation and release. In order to achieve this, the survival of medfly embryos of different ages was assessed after storage at 5, 10, 15, 20, and 25 deg. C in water for different periods of time. Survival was affected by all 3 variables, i.e., embryo age, water temperature, and length of storage. Storage of embryos at any temperature for 120 h resulted in almost no survival. Controlling the age of the embryo at the time of the temperature treatment is crucial for the success of this procedure. Embryos collected between 0 to 12 h after oviposition and pre-incubated at 25 deg. C for 12 h provide a suitable 72 h window for shipment when maintained between 10 to 15 deg. C. Under these conditions, no significant reductions in survival during all the developmental stages were observed. (author) [Spanish] El uso operacional de cepas de la mosca del mediterraneo Ceratitis capitata (Wiedemann) en las cuales es posible separar los sexos a traves de mecanismos geneticos para su utilizacion en la Tecnica del Insecto Esteril (TIE), puede ser maximizado con el desarrollo de metodos efectivos para el envio y transporte de huevos. Esto permite que un laboratorio de produccion centralizada mantenga las respectivas colonias responsables por la produccion de huevos para este abastecer laboratorios satelites responsables por la produccion masiva de solamente machos para subsiguiente irradiacion y liberacion. Para ser posible esta alternativa fue evaluada la supervivencia de embriones de diferentes edades despues de su almacenamiento en agua a 5, 10, 15, 20 y 25 deg. C por diferentes periodos de tiempo. La supervivencia fue afectada por las 3 variables evaluadas, la edad del embrion, la temperatura del agua y el periodo de almacenamiento. El almacenamiento de los embriones a cualquier temperatura por 120 horas dio como resultado la casi no supervivencia. Una edad controlada de los embriones a tratar es crucial para el exito de este protocolo. Embriones colectados entre 0 a 12 horas despues de la oviposicion y su previa incubacion a 25 deg. C por 12 horas brinda un margen de hasta de 72 horas de duracion del almacenamiento y transporte, siempre y cuando estos se mantengan en una temperatura de entre 10 a 15{sup o}C. En estas condiciones, fue registrada una reduccion no significante de la supervivencia de los diferentes estados de desarrollo. (author)

Caceres, C.; Wornoayporn, V.; Islam, S.M.; Ahmad, S. [Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Agency's Laboratories, A-2444 Seibersdorf (Austria); Ramirez, E. [Programa Moscamed-Guatemala, Planta de Produccion de Mosca del Mediterraneo km 48, Carretera a El Salvador, El Cerinal, Barberena, Santa Rosa (Guatemala)

2007-03-15

25

Mecanismo(s) de Acci³n de los Herbicidas Aux­nicos - Parte 2 - Nivel Avanzado  

NSDL National Science Digital Library

Descripci³n:El control selectivo de malezas de hoja ancha en cultivos de cereales por los herbicidas aux­nicos ha hecho de ©stos una de las familias de herbicidas actualmente en uso mas ampliamente distribuidas e importantes. Se cree que estos herbicidas actºan como simuladores hormonales. En esta lecci³n se detallar¡ la relaci³n estructural y fisiol³gica entre los herbicidas aux­nicos y la fitohormona natural auxina (¡cido indol-3-ac©tico; IAA por sus siglas en ingl©s) y se explicar¡n los mecanismos bioqu­micos que pueden estar involucrados en su modo de acci³n. Se revisar¡ el mecanismo de transporte de c©lula a c©lula y la absorci³n de las auxinas por las c©lulas, as­ como tambi©n la forma en que estas mol©culas causan elongaci³n celular e inducen la s­ntesis de etileno. De igual forma, se describir¡n los receptores, las rutas de transferencia de se±ales y los cambios en expresi³n gen©tica inducidos por la fitohormona natural IAA y su relaci³n con la actividad de los herbicidas aux­nicos.

26

Finding flows in the one-way measurement model  

SciTech Connect

The one-way measurement model is a framework for universal quantum computation in which algorithms are partially described by a graph G of entanglement relations on a collection of qubits. A sufficient condition for an algorithm to perform a unitary embedding between two Hilbert spaces is for the graph G, together with input and output I, O vertices I,O is contained in V(G), to have a flow in the sense introduced by Danos and Kashefi [Phys. Rev. A 74, 052310 (2006)]. For the special case of |I|=|O|, using a graph-theoretic characterization, I show that such flows are unique when they exist. This leads to an efficient algorithm for finding flows by a reduction to solved problems in graph theory.

Beaudrap, Niel de [Institute for Quantum Computing, University of Waterloo 200 University Avenue West, Waterloo, Ontario, N2L 3G1 (Canada)

2008-02-15

27

NUMERICAL ANALYSIS OF THE FOKKER-PLANCK EQUATION WITH ADIABATIC FOCUSING: ISOTROPIC PITCH-ANGLE SCATTERING  

SciTech Connect

We present numerical solutions to both the standard and modified two-dimensional Fokker-Planck equations with adiabatic focusing and isotropic pitch-angle scattering. With the numerical solution of the particle distribution function, we then discuss the related numerical issues, calculate the parallel diffusion coefficient using several different methods, and compare our numerical solutions for the parallel diffusion coefficient to the analytical forms derived earlier. We find the numerical solution to the diffusion coefficient for both the standard and modified Fokker-Planck equations agrees with that of Shalchi for the mean squared displacement method of computing the diffusion coefficient. However, we also show the numerical solution agrees with that of Litvinenko and Shalchi and Danos when calculating the diffusion coefficient via the velocity correlation function.

Danos, Rebecca J.; Fiege, Jason D.; Shalchi, Andreas, E-mail: rjdanos@physics.umanitoba.ca, E-mail: fiege@physics.umanitoba.ca, E-mail: shalchi@physics.umanitoba.ca [Department of Physics, University of Manitoba, Winnipeg, MB R3T 2N2 (Canada)

2013-07-20

28

Symplectic group structure of the Cr48,Ru88, and Pd92 ground states  

NASA Astrophysics Data System (ADS)

The ground states of Cr48,Ru88, and Pd92 are studied in the 1f7/2 or 1g9/2 shell model with effective interactions from the literature. They are found to be composed, quite independently of the shell and the interaction, roughly of 75% of (s,t)=(0,0) and 25% of (s,t)=(4,0), where s is the seniority and t the reduced isospin. Other irreps of the symplectic group Sp (2j+1), where j is the single-nucleon angular momentum, make only very small contributions. The state ? obtained by antisymmetrization and normalization of the ground state in the stretch scheme of Danos and Gillet [M. Danos and V. Gillet, Phys. Rev. 161, 1034 (1967), 10.1103/PhysRev.161.1034] has a very different structure where the Sp (2j+1) irreps other than (s,t)=(0,0) and (4,0) contribute 20% and 41% for j =7/2 and 9/2, respectively. The contributions of ? and the s =0 state to the calculated states are about equal for Cr48. For Ru88 and Pd92 the s =0 state is unambigously a better approximation to the calculated states than ?. A state ?' obtained by antisymmetrization and normalization of the product of two stretch-scheme ground states of the system with two valence nucleons or nucleon holes of each type has much larger overlaps with the calculated ground states than ? but a deviating Sp (2j+1) decomposition.

Neergrd, K.

2014-07-01

29

First report of the L1014S kdr mutation in wild populations of Anopheles gambiae M and S molecular forms in Burkina Faso (West Africa).  

PubMed

We investigated the occurrence of the L1014F and L1014S kdr mutations in malaria vector populations in Burkina Faso (West Africa). A cross-sectional survey was conducted at 10 sites all located in cotton cultivation areas which are assumed to be the major insecticide resistance selection foci in Burkina Faso. The hot ligation method was used to detect the two kdr mutations in field collected Anopheles gambiae s.l. samples. For the first time in Burkina Faso the L1014S mutation was identified in both M and S forms of An. gambiae s.s. populations collected from the site of Koupela in the central-eastern region at low frequency. Furthermore, the L1014S mutation was also found in one specimen of An. arabiensis collected from the Dano site. The data generated in this study provides additional evidence of the spread of the L1014S mutation into An. gambiae s.l. populations in West Africa. It is now important to evaluate the role of the L1014S mutation in the pyrethroid resistance phenotype and assess its potential impact on the efficacy of pyrethroid-based control measures in West Africa where several resistance mutations now coexist. PMID:23128044

Namountougou, Moussa; Diabat, Abdoulaye; Etang, Josiane; Bass, Chris; Sawadogo, Simon P; Gnankini, Olivier; Baldet, Thierry; Martin, Thibaud; Chandre, Fabrice; Simard, Frdric; Dabir, Roch K

2013-02-01

30

Development of an Immunochromatographic Strip Test for Rapid Detection of Ciprofloxacin in Milk Samples  

PubMed Central

A rapid, simple, and sensitive immunochromatographic test strip has been developed for testing residues of ciprofloxacin (CIP). A specific and sensitive monoclonal antibody (mAb) for CIP was generated by immunizing BALB/c mice with well-characterized CIP-Keyhole limpet haemocyanin. Under the optimized conditions, the cut-off limits of test strips for CIP were found to be 5 ng/mL in phosphate-buffered saline and 2.5 ng/mL in milk samples. Each test can be evaluated within 3 min. The cross-reactivities of the CIP test strip to enrofloxacin (ENR), norfloxacin (NOR), nadifloxacin (NDF), danofloxacin (DANO), pefloxacin (PEX), lomefloxacin (LOME), enoxacin (ENO), and sarafloxacin (SAR) were 71.4%, 71.4%, 66%, 50%, 33%, 20%, 12.5%, and 6.25%, respectively. The data indicate that the method is sensitive, specific, and has the advantages of simplicity and speed, therefore, this test strip is a useful screening method for the detection of CIP residues in milk samples. PMID:25211194

Liu, Liqiang; Luo, Liju; Suryoprabowo, Steven; Peng, Juan; Kuang, Hua; Xu, Chuanlai

2014-01-01

31

Plasminogen activator in mammalian skeletal muscle: characteristics of effect of denervation on urokinase-like and tissue activator  

PubMed Central

Analyses were made of the fibrinolytic, plasminogen-activating system in skeletal muscle to determine if a regulating influence of the nerve could be detected on these enzymes. Young male mice underwent right sciatic neurectomy. Extracts were prepared from denervated muscle at 2- 17 d after axotomy and compared with controls. Using a cascade-style biochemical assay (Ranby, M., B. Norrman, and P. Wallen, 1982, Thromb. Res., 27:743-748) we found that low levels of plasminogen activator (PA) were present in adult, innervated mouse muscle, but that denervation resulted in a marked time-dependent increase in enzyme activity. Qualitative separation showed an eightfold increase in urokinase-like PA with moderate elevation of tissue PA activity after 10 d. Fibrin zymography (Granelli-Piperno, A., and E. Reich, 1978, J. Exp. Med., 148:223-234) revealed clear zones of lysis corresponding to molecular masses of 48 kD for urokinase-like PA and 75 kD for tissue PA, consistent with the molecular masses found for these enzymes in other tissues of the mouse (Dano, K., P. A. Andreasen, J. Grondahl- Hansen, P. Kristensen, L. S. Nielsen, and L. Skriver, 1985, Adv. Cancer Res., 44:139-266). In other studies we have shown that PA-activated plasmin readily attacks critical adhesive basement membrane molecules. The present results indicate that enzymes involved in plasminogen activation, particularly urokinase-like PA, rapidly increase after axotomy, suggesting they may have a role early in muscle denervation. Similar alterations in PA activity might underlie the elimination of polyneuronal innervation during mammalian muscle development. Certain neuromuscular diseases may also involve activation of these enzymes, resulting in degradation of basement membrane zone components and, therefore, warrant further study. PMID:3095333

1986-01-01

32

Improving Short Wave Breaking Behavior In Surfbeat Models  

NASA Astrophysics Data System (ADS)

In present surfzone modeling three approaches are widely applied: short-wave resolving models, surfbeat models, which resolve wave energy modulations on the time-scale of wave groups and their associated infragravity waves, and wave averaged models. In all three approaches, wave breaking is a process that is highly schematized and governed by several empirical coefficients. In this presentation we will focus on the breaking process in surfbeat models, such as XBeach (Roelvink et al, 2009). These models need to describe the short wave dissipation by breaking as a function of the slowly-varying short wave energy or wave height. The model usually applied is that by Roelvink (1993), which combines a probability that waves are breaking as function of wave heigth over water depth ratio H/h with a bore-type dissipation formulation similar to that by Battjes and Janssen (1978). A drawback of such a formulation is that there is no memory in the breaking process, and the amount of breaking instantly varies with the water depth (though the wave height itself does have a memory). For cases with bichromatic waves, or for long-period swell, this does not reflect reality enough: waves that start breaking do not instantly stop breaking once the water depth increases, but continue until some lower threshold is reached. This concept was captured in Dallys (1992) wave-by-wave approach, where individual waves are tracked in a probabilistic setting. We have now implemented a similar formulation in XBeach, where the property that waves are breaking is tracked; it is switched on when H/h exceeds a first criterion; this property is propagated using an advection equation and when H/h gets below a second criterion breaking is switched off. This formulation can do two things the previous one cant: maintain groupiness inside the surf zone and have a maximum of wave breaking in the trough after a steep bar, as was observed for instance in Arcilla et als (1994) test 1C. Obviously this has important consequences for the forcing of both long waves and mean currents. In our presentation we will show results of comparisons of both formulations. References. Arcilla, A.S., Roelvink, J.A., O'Connor, B.A. Reniers, A., and Jimenez. J.A. The Delta Flume '93 Experiment. Coastal Dynamics '94. Arcilla, Stive and Kraus (eds), ASCE, New York, pp. 488-502. Battjes, J.A. and J.P.F.M. Janssen, (1978), Energy loss and set-up due to breaking in random waves, Proc. 16th Int. Coastal Eng. Conf., Hamburg, vol. 1: 569-587. Dally, W.R. (1992) Random breaking waves: Field verification of a wave-by-wave algorithm for engineering application. Coastal Engineering, Volume 16, Issue 4, March 1992, Pages 369-397. Roelvink, Dano, Ad Reniers, Ap van Dongeren, Jaap van Thiel de Vries, Robert McCall, Jamie Lescinski. Modelling storm impacts on beaches, dunes and barrier islands, Coast. Eng. (2009), doi:10.1016/j.coastaleng.2009.08.006 Roelvink, J.A. Dissipation in random wave groups incident on a beach. Coastal Eng., 19 (1993) pp. 127-150.

Roelvink, J.; Daly, C.; Vandongeren, A. R.; van Thiel de Vries, J.; McCall, R.

2009-12-01