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The new Genetico-Racial Skin Classification: How to maximize the safety of any peel or laser treatment on any Asian, Caucasian or Black patient  

PubMed Central

The popular skin classifications, notably the ‘Fitzpatrick’ and ‘Obaji’ classifications, are primarily based on skin colour. Other criteria are occasionally considered, such as the degree of skin oiliness, thickness, sensibility, etc. Although these classifications are easy to understand and apply, their simplicity limits their precision, sophistication and applicability. The new genetico-racial skin classification proposed herein suggests that skin response to any peel or laser treatment is genetically programmed and is, therefore, linked to the genetic and racial origin of the patient. In other words, in addition to skin colour, the patient’s facial features and ancestry should be taken into account when classifying any skin. The new genetico-racial skin classification enables the physician to determine with great precision, and before any peel or laser treatment, the level of the patient’s suitability and the expected postoperative outcomes; therefore, reducing the likelihood of complications. PMID:22379368

Fanous, Nabil; Côté, Valérie; Fanous, Amanda



Brunet Estarelles, Pere J., y Glvez Capell, Francisco, J. (1995). Estructura urbana y movilidad: anlisis del trfico inducido por el Campus de la Universitat de les Illes  

E-print Network

Brunet Estarelles, Pere J., y Gálvez Capellá, Francisco, J. (1995). Estructura urbana y movilidad Nacional de Geografía. Salamanca. Pp: 322-325. ESTRUCTURA URBANA Y MOVILIDAD. ANALISIS DEL TRAFICO INDUCIDO). Estructura urbana y movilidad: análisis del tráfico inducido por el Campus de la Universitat de les Illes

Oro, Daniel


The Measurement Calculus Vincent Danos  

E-print Network

, the recently introduced one-way quantum computer [RB01] stands out as fundamental. We develop a rigorous mathematical model underlying the one-way quantum computer and present a concrete syntax and operational a general impact on measurement- based computation and is not just particular to the one-way quantum

Panangaden, Prakash


Pauli measurements are universal Vincent Danos (CNRS, Univ Paris 7)  

E-print Network

as an important theoretical quantum computing model, it is only recently that some of its measurement patterns a potentially useful simplification of the underlying hardware needed to realise the feedforward mechanism. We is irrelevant to the result of a computation. The instruction M i stands for a one qubit measurement applied

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7


Timeless games Patrick Baillot 1 , Vincent Danos 2 , Thomas Ehrhard 1 , and Laurent Regnier 1  

E-print Network

and plays. The point is that evaluation is now modeled as a communication, a composition that takes time describe communication between strategies. But to be a middle ground one needs to relate to both parties of evaluation. 1 Introduction The basic mathematical reflex was to model types, programs, evaluation with sets

Provence Aix-Marseille I, Université de


Extended Measurement Calculus Vincent Danos, Elham Kashefi, Prakash Panangaden, Simon Perdrix  

E-print Network

interact. Traditionally, the main framework to explore quantum computation has been the circuit model Gottesman and Chuang (1999) who used two-qubit measurements and given Bell pairs. The one-way computer.1 Introduction The emergence of quantum computation has changed our perspective on many fundamental aspects

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7


The syntectonic Middle Mesoproterozoic Karlshamn granitoid pluton, S. Sweden: ENE-WSW shortening during the Dano-Polonian orogeny  

Microsoft Academic Search

Granitoid intrusions of 1.50-1.45 Ga age make up a significant part of the Palaeoproterozoic crust in the region around the southern Baltic Sea. They also occur in middle and northern Sweden, and in Belarus. Most of these intrusions have been considered ``anorogenic'' because of the presence of rapakivi texture and some geochemical characteristics of the granitoids, and because of the

A. Cecys; K. Benn; S. V. Bogdanova



Quadratic Form Expansions for Unitaries Niel de Beaudrap1, Vincent Danos2, Elham Kashefi3, Martin Roetteler4  

E-print Network

such a form to an entangled resource akin to that of the one-way measurement model of quantum computing. Using expansion for U from other input data. 1 Introduction In the one-way measurement model [1, 2], quantum and ancillas prepared in the |+ state. This model lends itself to ways of analyzing quantum computation which

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7


Universit degli Studi di Roma "La Sapienza" Presidenza della Facolt di Scienze MFN  

E-print Network

Sem. LM- GBM Regolazione post- trascrizionale - Mod.2 BIO11 9 4 I I LM- GBM Metodologie genetico- molecolari nell'uomo - Mod. 3 BIO18 6 2 I I LM- GBM Biologia Molecolare dello sviluppo delle piante - Mod. 1 BIO11 6 3 I/II II LM- GBM Biologia Molecolare dello sviluppo delle piante - Mod. 2 BIO11 6 3 I/II II

Guidoni, Leonardo



PubMed Central

The causes and the nature of the psychiatric disorder labeled schizophrenia remain vexingly obscure. Perhaps as an expression of a still extant body-mind controversy, most of the experiments and statements made toward an elucidation of the problem follow one or the other of two opposing postulations: (a) That its origin is genetico-organic; (b) that it is environmental. In a review of the outstanding “facts” for either argument, it is notable that they presuppose not only a difference in theoretical frameworks, but two radically distinct outlooks. This is reflected in therapy, a field in which organicists and environmentalists stand even further apart; the organicist, relying heavily on electroshock and drugs, hopes to counteract a hypothetical body malfunction, and the environmentalist, through psychotherapy, attempts to make it possible for the patient to disentangle his own conflicting feelings and reaction patterns. Between the two an eclectic position seems hardly tenable. For, in spite of voluminous research and speculation, it has not been possible to build a bridge between the two camps and integrate different outlooks which, at times, have brought psychiatry almost to the point of schism. PMID:13699087

Ferreira, Antonio J.



Determination of heparin using terbium-danofloxacin as a luminescent probe  

NASA Astrophysics Data System (ADS)

A new spectrofluorimetric method is described for the determination of trace amounts of heparin (Hep) using terbiumdanofloxacin (Tb3+-Dano) as a fluorescent probe. Hep can enhance the fluorescence intensity of the Tb3+-Dano complex at 545 nm, and the enhanced fluorescence intensity of the Tb3+ ion is proportional to the concentration of Hep. Optimum conditions for the determination of Hep are: pH 7.2, [Tb3+] = 4.0 · 10-5 mol/l, and [Dano] =2.5 · 10-5 mol/l. A dynamic range for the determination of Hep is 0.1-1.5 ?g/ml with a detection limit (S/N = 3) of 24.62 ng/ml. The proposed method is simple, practical, and relatively free from interferences.

Manzoori, Jamshid L.; Jouyban, Abolghasem; Amjadi, Mohammad; Ramezani, Amir M.



FALL 2012 NEWSLETTER A Message from the Chair  

E-print Network

, an internationally recognized geometer from Brown University, and Dano Johnson, a successful director and animator Fibonacci and Steve Jobs" was based on two of his latest books. Sam Vandervelde, a well-known number is the Middle of a Fibonacci Sequence?" Please join us at our annual Homecoming breakfast reception on the first

Littlejohn, Lance


Modelling epigenetic information maintenance a Kappa tutorial  

E-print Network

Modelling epigenetic information maintenance a Kappa tutorial Jean Krivine1 , Vincent Danos2, that of the maintenance of epigenetic information. Our plan is to: - articulate in purely biological terms an epigenetic make progress in our plan. 1 Epigenetic repair Key epigenetic information is encoded in the human

Paris-Sud XI, Université de


Modelling epigenetic information maintenance a Kappa tutorial  

E-print Network

Modelling epigenetic information maintenance a Kappa tutorial Jean Krivine1 , Vincent Danos2, that of the maintenance of epigenetic information. Our plan is to: - propose in biological and informal terms a repair Epigenetic repair Epigenetic information is encoded in the human genome via a chemical modification of C

Danos, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7


The Alma Mater Society of U.B.C. Vancouver November 28, 2012 PLACE: Council Chambers SUB Room 206  

E-print Network

(AMS Bookings), Philip He (AMS SAC), Kevin Emms (Alumni/Professional Brewer), Dano Morrison (Student Ruck, Sebastian Silley, Noah Stewart, Eric Toyota, Kyle Warwick, Caroline Wong, Justin Yang Abstained-design advanced, restarting the project. Bird Construction has been pushing us to complete the brewery drawings

Pulfrey, David L.


O aproveitamento da energia eolica (The wind energy resource)  

Microsoft Academic Search

Diversos estudos realizados nosultimos anos tem apontado as implicacoes e impactos socio-ambientais do consumo de energia. As fontes renovaveis de energia sao apresentadas como a principal alternativa para atender as demandas da sociedade com relacaoa qualidade e seguranca do atendimento da demanda de eletricidade com a reducao dos danos ambientais decorrentes do consumo de energia. Este artigo apresenta uma revisao

F. R. Martins; R. A. Guarnieri; E. B. Pereira



Microsoft Academic Search

RESUMO - O eucalipto é a espécie florestal mais plantada no Brasil, e por pertencer à família Myrtaceae sofre ataques de insetos que migram de hospedeiros nativos dessa planta, entre os quais Oxydia vesulia (Lepidoptera: Geometridae), espécie responsável por danos significativos a plantas desse grupo, em várias regiões do País. O estabelecimento e a preservação de reservas nativas têm sido

Germi Porto Santos; Teresinha Vinha Zanuncio; Eloisio Vinha; José Cola Zanuncio



Screening of Danofloxacin residue in bovine tissue by terbium-sensitized luminescence on C18 sorbent strips  

Technology Transfer Automated Retrieval System (TEKTRAN)

Danofloxacin (DANO) residue in bovine muscle was screened at 200 ng/g by terbium-sensitized luminescence (TSL) directly measured on 10x6 mm C18 sorbent strips. The analyte was first adsorbed on sorbent surface by immersion in defatted homogenates. After reagent application and desiccation, TSL was d...


Spectrofluorimetric determination of cefixime using terbium-danofloxacin probe  

PubMed Central

Objective(s): Cefixime (Cfx), is a semi-synthetic third-generation oral cephalosporin antibiotic that is prescribed for the treatment of susceptible infections. There are some procedures for the determination of Cfx in pharmaceutical formulations and biological samples. Herein a spectrofluorimetric method was proposed for Cfx determination based on the fluorescence quenching of terbium-danofloxacin (Tb3+-Dano) in the presence of Cfx. Materials and Methods: Cfx was detected based on fluorescence quenching of terbium-danofloxacin (Tb3+-Dano) in the presence of Cfx with maximum excitation and emission wavelengths at 347 nm and 545 nm, respectively. The quenched fluorescence intensity of Tb3+- Dano system is proportional to the concentration of Cfx. The optimum conditions for the determination of Cfx were studied. Results: The maximum response was achieved under optimum conditions of [Tris buffer]= 0.008 mol/l (pH 6.5), [Tb3+]=1×10-4 mol/l and [Dano]=1×10-4 mol/l. The developed method was evaluated in terms of accuracy, precision and limit of detection. The linear concentration ranges for quantification of Cfx were 8.8×10-8-8.8×10-7 mol/l and 1.1×10-7-8.8×10-7 mol/l in standard and human serum samples with the detection limits (S/N=3) of 2.8×10-8 mol/l and 3.9×10-8 mol/l, respectively. The Cfx was determined in pharmaceutical tablets and spiked serum samples and the results were satisfactory. Conclusion: This method is simple, practical and relatively interference-free for determination of Cfx in pharmaceutical tablets and serum samples. PMID:24904718

Manzoori, Jamshid L.; Amjadi, Mohammad; Soltani, Naser; Jouyban, Abolghasem



A protocol for storage and long-distance shipment of Mediterranean fruit fly (Diptera: Tephritidae) eggs. 1. Effect of temperature, embryo age , and storage time on survival and quality  

SciTech Connect

The operational use of Mediterranean fruit fly (medfly) Ceratitis capitata (Wiedemann), genetic sexing strains in Sterile Insect Technique applications can be maximized by developing methods for effective shipment of eggs. This would enable a central production facility to maintain the relevant mother stocks and large colonies to supply eggs to satellite centers that would mass produce only males for irradiation and release. In order to achieve this, the survival of medfly embryos of different ages was assessed after storage at 5, 10, 15, 20, and 25 deg. C in water for different periods of time. Survival was affected by all 3 variables, i.e., embryo age, water temperature, and length of storage. Storage of embryos at any temperature for 120 h resulted in almost no survival. Controlling the age of the embryo at the time of the temperature treatment is crucial for the success of this procedure. Embryos collected between 0 to 12 h after oviposition and pre-incubated at 25 deg. C for 12 h provide a suitable 72 h window for shipment when maintained between 10 to 15 deg. C. Under these conditions, no significant reductions in survival during all the developmental stages were observed. (author) [Spanish] El uso operacional de cepas de la mosca del mediterraneo Ceratitis capitata (Wiedemann) en las cuales es posible separar los sexos a traves de mecanismos geneticos para su utilizacion en la Tecnica del Insecto Esteril (TIE), puede ser maximizado con el desarrollo de metodos efectivos para el envio y transporte de huevos. Esto permite que un laboratorio de produccion centralizada mantenga las respectivas colonias responsables por la produccion de huevos para este abastecer laboratorios satelites responsables por la produccion masiva de solamente machos para subsiguiente irradiacion y liberacion. Para ser posible esta alternativa fue evaluada la supervivencia de embriones de diferentes edades despues de su almacenamiento en agua a 5, 10, 15, 20 y 25 deg. C por diferentes periodos de tiempo. La supervivencia fue afectada por las 3 variables evaluadas, la edad del embrion, la temperatura del agua y el periodo de almacenamiento. El almacenamiento de los embriones a cualquier temperatura por 120 horas dio como resultado la casi no supervivencia. Una edad controlada de los embriones a tratar es crucial para el exito de este protocolo. Embriones colectados entre 0 a 12 horas despues de la oviposicion y su previa incubacion a 25 deg. C por 12 horas brinda un margen de hasta de 72 horas de duracion del almacenamiento y transporte, siempre y cuando estos se mantengan en una temperatura de entre 10 a 15{sup o}C. En estas condiciones, fue registrada una reduccion no significante de la supervivencia de los diferentes estados de desarrollo. (author)

Caceres, C.; Wornoayporn, V.; Islam, S.M.; Ahmad, S. [Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Agency's Laboratories, A-2444 Seibersdorf (Austria); Ramirez, E. [Programa Moscamed-Guatemala, Planta de Produccion de Mosca del Mediterraneo km 48, Carretera a El Salvador, El Cerinal, Barberena, Santa Rosa (Guatemala)



A Non Parametric Model for the Forecasting of the Venezuelan Oil Prices  

E-print Network

A neural net model for forecasting the prices of Venezuelan crude oil is proposed. The inputs of the neural net are selected by reference to a dynamic system model of oil prices by Mashayekhi (1995, 2001) and its performance is evaluated using two criteria: the Excess Profitability test by Anatoliev and Gerko (2005) and the characteristics of the equity curve generated by a trading strategy based on the neural net predictions. ----- Se introduce aqui un modelo no parametrico para pronosticar los precios del petroleo Venezolano cuyos insumos son seleccionados en base a un sistema dinamico que explica los precios en terminos de dichos insumos. Se describe el proceso de recoleccion y pre-procesamiento de datos y la corrida de la red y se evaluan sus pronosticos a traves de un test estadistico de predictibilidad y de las caracteristicas del Equity Curve inducido por la estrategia de compraventa bursatil generada por dichos pronosticos.

Costanzo, Sabatino; Dehne, Wafaa; Prato, Hender



Mecanismo(s) de Acción de los Herbicidas Auxínicos - Parte 2 - Nivel Avanzado  

NSDL National Science Digital Library

Descripción:El control selectivo de malezas de hoja ancha en cultivos de cereales por los herbicidas auxínicos ha hecho de éstos una de las familias de herbicidas actualmente en uso mas ampliamente distribuidas e importantes. Se cree que estos herbicidas actúan como simuladores hormonales. En esta lección se detallará la relación estructural y fisiológica entre los herbicidas auxínicos y la fitohormona natural auxina (ácido indol-3-acético; IAA por sus siglas en inglés) y se explicarán los mecanismos bioquímicos que pueden estar involucrados en su modo de acción. Se revisará el mecanismo de transporte de célula a célula y la absorción de las auxinas por las células, así como también la forma en que estas moléculas causan elongación celular e inducen la síntesis de etileno. De igual forma, se describirán los receptores, las rutas de transferencia de señales y los cambios en expresión genética inducidos por la fitohormona natural IAA y su relación con la actividad de los herbicidas auxínicos.



SciTech Connect

We present numerical solutions to both the standard and modified two-dimensional Fokker-Planck equations with adiabatic focusing and isotropic pitch-angle scattering. With the numerical solution of the particle distribution function, we then discuss the related numerical issues, calculate the parallel diffusion coefficient using several different methods, and compare our numerical solutions for the parallel diffusion coefficient to the analytical forms derived earlier. We find the numerical solution to the diffusion coefficient for both the standard and modified Fokker-Planck equations agrees with that of Shalchi for the mean squared displacement method of computing the diffusion coefficient. However, we also show the numerical solution agrees with that of Litvinenko and Shalchi and Danos when calculating the diffusion coefficient via the velocity correlation function.

Danos, Rebecca J.; Fiege, Jason D.; Shalchi, Andreas, E-mail:, E-mail:, E-mail: [Department of Physics, University of Manitoba, Winnipeg, MB R3T 2N2 (Canada)



Detección y estudio mediante Fluorescencia Inducida por Láser de radicales libres formados por Disociación Multifotónica Infrarroja  

NASA Astrophysics Data System (ADS)

Una de las principales aplicaciones actuales de los procesos de disociación multifotónica inducidos por radiación láser infrarroja (DMI) es la producción de radiales libres, con el fin de estudiar sus propiedades cinéticas y espectroscópicas. La disociación de moléculas poliatómicas en el IR con láseres de CO2 tiene lugar desde la superficie de energía molecular mas baja y conduce generalmente a la formación de fragmentos en el estado electrónico fundamental, con diversos grados de excitación vibracional. En el Grupo de Procesos Multifotónicos del Instituto de Estructura de la Materia del C.S.I.C. hemos puesto a punto la técnica de Fluorescencia Inducida por Láser (LIF) para la detección y análisis en tiempo real de los fragmentos producidos en la DMI inducida mediante uno o dos campos láseres de diferentes longitudes de onda. Objetivos de nuestro trabajo han sido el estudio de los canales de disociación mayoritarios y de las especies transitoria producidas, así como de la distribución de energía interna con que éstas son generadas. En particular hemos detectado mediante LIF las especies: C2, CF, CH, SiH2, CF2, CH2, SiHCl, y CF3 a partir de la disociación de, entre otras, las siguientes moléculas: C2H3Br, C3F6, C4H8Si, C2H5ClSi y CH5ClSi. En este trabajo presentamos algunos de los resultados obtenidos mediante el estudio por LIF de estos radicales: estudio temporal de la señal LIF obtenida con determinación de tiempos de vida, espectros de excitación y fluorescencia, temperaturas vibracionales de formación, variación de la intensidad LIF con el tiempo de retraso entre los láseres de disociación y prueba, etc.

Santos, M.; Díaz, L.; Torresano, J. A.; Rubio, L.; Samoudi, B.


Development of an immunochromatographic strip test for rapid detection of ciprofloxacin in milk samples.  


A rapid, simple, and sensitive immunochromatographic test strip has been developed for testing residues of ciprofloxacin (CIP). A specific and sensitive monoclonal antibody (mAb) for CIP was generated by immunizing BALB/c mice with well-characterized CIP-Keyhole limpet haemocyanin. Under the optimized conditions, the cut-off limits of test strips for CIP were found to be 5 ng/mL in phosphate-buffered saline and 2.5 ng/mL in milk samples. Each test can be evaluated within 3 min. The cross-reactivities of the CIP test strip to enrofloxacin (ENR), norfloxacin (NOR), nadifloxacin (NDF), danofloxacin (DANO), pefloxacin (PEX), lomefloxacin (LOME), enoxacin (ENO), and sarafloxacin (SAR) were 71.4%, 71.4%, 66%, 50%, 33%, 20%, 12.5%, and 6.25%, respectively. The data indicate that the method is sensitive, specific, and has the advantages of simplicity and speed, therefore, this test strip is a useful screening method for the detection of CIP residues in milk samples. PMID:25211194

Liu, Liqiang; Luo, Liju; Suryoprabowo, Steven; Peng, Juan; Kuang, Hua; Xu, Chuanlai



A Prospective Study on Time to Recovery in 254 Injured Novice Runners  

PubMed Central

Objectives Describe the diagnoses and the time to recovery of running-related injuries in novice runners. Design Prospective cohort study on injured runners. Method This paper is a secondary data analysis of a 933-person cohort study (DANO-RUN) aimed at characterizing risk factors for injury in novice runners. Among those sustaining running-related injuries, the types of injuries and time to recovery is described in the present paper. All injured runners were diagnosed after a thorough clinical examination and then followed prospectively during their recovery. If they recovered completely from injury, time to recovery of each injury was registered. Results A total of 254 runners were injured. The proportion of runners diagnosed with medial tibial stress syndrome was 15%, 10% for patellofemoral pain, 9% for medial meniscal injury, 7% for Achilles tendinopathy and 5% for plantar fasciitis. Among the 220 runners (87%) recovering from their injury, the median time to recovery was 71 days (minimum ?=?9 days, maximum ?=?617 days). Conclusions Medial tibial stress syndrome was the most common injury followed by patellofemoral pain, medial meniscal injury and Achilles tendinopathy. Half of the injured runners were unable to run 2×500 meters without pain after 10 weeks. Almost 5% of the injured runners received surgical treatment. PMID:24923269

Nielsen, Rasmus Oestergaard; Rønnow, Lotte; Rasmussen, Sten; Lind, Martin



An analysis of the trade-off between spatial and temporal resources for measurement-based quantum computation  

E-print Network

In measurement-based quantum computation (MBQC), elementary quantum operations can be more parallelized than the quantum circuit model by employing a larger Hilbert space of graph states used as the resource. Thus MBQC can be regarded as a method of quantum computation where the temporal resource described by the depth of quantum operations can be reduced compared to the quantum circuit model by using the extra spatial resource described by graph states. To analyze the trade-off relationship of the spatial and temporal resources, we consider a method to obtain quantum circuit decompositions of general unitary transformations represented by MBQC on graph states with a certain underlying geometry called generalized flow. We present a method to translate any MBQC with generalized flow into quantum circuits without extra spatial resource. We also show an explicit way to unravel acausal gates that appear in the quantum circuit decomposition derived by a translation method presented in [V. Danos and E. Kashefi, Phys. Rev. A {\\bf 74}, 052310 (2006)] and that represent an effect of the reduction of the temporal resource in MBQC. Finally, by considering a way to deterministically simulate these acausal gates, we investigate a general framework to analyze the trade-off between the spacial and temporal resources for quantum computation.

Jisho Miyazaki; Michal Hajdušek; Mio Murao



Development of an Immunochromatographic Strip Test for Rapid Detection of Ciprofloxacin in Milk Samples  

PubMed Central

A rapid, simple, and sensitive immunochromatographic test strip has been developed for testing residues of ciprofloxacin (CIP). A specific and sensitive monoclonal antibody (mAb) for CIP was generated by immunizing BALB/c mice with well-characterized CIP-Keyhole limpet haemocyanin. Under the optimized conditions, the cut-off limits of test strips for CIP were found to be 5 ng/mL in phosphate-buffered saline and 2.5 ng/mL in milk samples. Each test can be evaluated within 3 min. The cross-reactivities of the CIP test strip to enrofloxacin (ENR), norfloxacin (NOR), nadifloxacin (NDF), danofloxacin (DANO), pefloxacin (PEX), lomefloxacin (LOME), enoxacin (ENO), and sarafloxacin (SAR) were 71.4%, 71.4%, 66%, 50%, 33%, 20%, 12.5%, and 6.25%, respectively. The data indicate that the method is sensitive, specific, and has the advantages of simplicity and speed, therefore, this test strip is a useful screening method for the detection of CIP residues in milk samples. PMID:25211194

Liu, Liqiang; Luo, Liju; Suryoprabowo, Steven; Peng, Juan; Kuang, Hua; Xu, Chuanlai



Simulação de ejeções de massa coronal  

NASA Astrophysics Data System (ADS)

Ejeções de massa coronal (EMC) são bolhas gigantes de gás permeadas por campos magnéticos que são ejetadas do Sol durante um período de várias horas. Caso estas ejeções atinjam a Terra, geralmente, causam uma série de distúrbios às comunicações de longa distância e navegação, além de danos a satélites e transformadores. Portanto, é desejável que sejamos capazes de prever quando estas ejeções atingirão a Terra. Para tanto, é necessário um bom entendimento dos mecanismos causadores das ejeções e, principalmente, de como se dá a propagação das EMC e sua interação com o vento solar que permeia o meio interplanetário. Nesse sentido foi desenvolvido um programa computacional para resolver as equações MHD (Magneto-Hidro-Dinâmica) que regem a evolução das EMC. Primeiramente foram estabelecidas as condições necessárias para descrever o vento solar, no estado estacionário, que permeia todo o meio interplanetário. Num primeiro momento, resolveu-se o sistema de equações para o caso do vento isotérmico, conhecida como a solução de Parker, a fim de testarmos o modelo. Então, foi considerado o caso do vento solar com temperatura variável no meio interplanetário. Este resultado foi utilizado como a base de nosso sistema em seu instante inicial. Posteriormente foram feitas as considerações necessárias para descrever a propagação da Ejeção de Massa Coronal. As EMC foram simuladas como um aumento de densidade e temperatura local na coroa solar. A órbita e a posição da Terra foram incluídas no sistema. Os dados gerados possibilitaram uma análise da evolução da EMC pelo meio interplanetário até encontrar-se com a Terra. Os perfis de densidade e temperatura a 1 Unidade Astronômica são comparados com os dados de satélites reportados na literatura.

Corsini, M. A.; Silva, A. V. R.



Characterization of producer cell-dependent restriction of murine leukemia virus replication.  


We previously reported that the human bronchocarcinoma cell line A549 produces poorly infectious gibbon ape leukemia virus-pseudotyped Moloney murine leukemia virus (MLV). In contrast, similar amounts of virions recovered from human fibrosarcoma HT1080 cells result in 10-fold-higher transduction rates (G. Duisit, A. Salvetti, P. Moullier, and F. Cosset, Hum. Gene Ther. 10:189-200, 1999). We have now extended this initial observation to other type-C envelope (Env) pseudotypes and analyzed the mechanism involved. Structural and morphological analysis showed that viral particles recovered from A549 (A549-MLV) and HT1080 (HT1080-MLV) cells were normal and indistinguishable from each other. They expressed equivalent levels of mature Env proteins and bound similarly to the target cells. Furthermore, incoming particles reached the cytosol and directed the synthesis of linear viral DNA equally efficiently. However, almost no detectable circular DNAs could be detected in A549-MLV-infected cells, indicating that the block of infection resulted from defective nuclear translocation of the preintegration complex. Interestingly, pseudotyping of A549-MLV with vesicular stomatitis virus glycoprotein G restored the amount of circular DNA forms as well as the transduction rates to HT1080-MLV levels, suggesting that the postentry blockage could be overcome by endocytic delivery of the core particles downstream of the restriction point. Thus, in contrast to the previously described target cell-dependent Fv-1 (or Fv1-like) restriction in mammalian cells (P. Pryciak and H. E. Varmus, J. Virol. 66:5959-5966, 1992; G. Towers, M. Bock, S. Martin, Y. Takeuchi, J. P. Stoye, and O. Danos, Proc. Natl. Acad. Sci. USA 97:12295-12299, 2000), we report here a new restriction of MLV replication that relies only on the producer cell type. PMID:12050374

Serhan, Fatima; Jourdan, Nathalie; Saleun, Sylvie; Moullier, Philippe; Duisit, Ghislaine



Was the 19th Century end of the Little Ice Age in the Alps forced by industrial black carbon?  

NASA Astrophysics Data System (ADS)

Glaciers in the European Alps began to retreat abruptly from their mid 19th century maximum, marking what appeared to be the end of the Little Ice Age. Alpine temperature and precipitation records suggest that glaciers should instead have continued to grow until circa 1910. Our current knowledge of the Alpine climate, climatologists consider the climatic end of the LIA to have come markedly later than the glaciological end, resulting in a paradox. Simulations of glacier length variations using glacier flow and mass balance models forced with instrumental and proxy temperature and precipitation fail to match the timing and magnitude of the observed late 19th century retreat. Matches between simulations and observations have only been achieved when additional glacier mass loss is imposed after 1865 or when precipitation signals are generated that would fit the glacier retreat rather than using actual precipitation records. A known transition however did occur across that half century and into the 20th century that may have held powerful potential consequences for absorption of solar radiation, earlier melt of snow cover, and, in turn, the retreat of glaciers. That transition was the dramatic rise in a byproduct of industrialization: black carbon. Ice cores indicate that BC concentrations increased abruptly at mid 19th century and largely continued to increase into the 20th century, consistent with known increases in BC emissions from the industrialization of Western Europe. We estimate the radiative forcings by these changes in BC loading and whether they were of sufficient magnitude to produce the pronounced negative glacier mass balance that began mid 19th century. Inferred annual surface radiative forcings increased stepwise to 13-17 W m-2 between 1850 and 1880, and to 9-22 W m-2 in the early 1900s, with snowmelt season (April/May/June) forcings reaching greater than 35 W m-2 by the early 1900s. These snowmelt season radiative forcings would have resulted in additional annual snow melting of as much as 0.9 m water equivalent across the melt season. Simulations of glacier mass balances with radiative forcing equivalent changes in atmospheric temperatures result in conservative estimates of accumulating negative mass balances of magnitude -15 m water equivalent by 1900 and -30 m water equivalent by 1930, magnitudes and timing consistent with the observed retreat. These results suggest a possible physical explanation for the abrupt retreat of glaciers in the Alps in the mid 19th century that is consistent with existing temperature and precipitation records and reconstructions. Fig. 3 Atmospheric structure in the Swiss Alps, photo courtesy of Dano Olivieri (

Painter, T. H.; Flanner, M.; Marzeion, B.; Kaser, G.; VanCuren, R. A.; Abdalati, W.



Validation of the Earthquake Archaeological Effects methodology by studying the San Clemente cemetery damages generated during the Lorca earthquake of 2011  

NASA Astrophysics Data System (ADS)

The intensity scales determined the damage caused by an earthquake. However, a new methodology takes into account not only the damage but the type of damage "Earthquake Archaeological Effects", EAE's, and its orientation (e.g. displaced masonry blocks, conjugated fractures, fallen and oriented columns, impact marks, dipping broken corners, etc.) (Rodriguez-Pascua et al., 2011; Giner-Robles et al., 2012). Its main contribution is that it focuses not only on the amount of damage but also in its orientation, giving information about the ground motion during the earthquake. Therefore, this orientations and instrumental data can be correlated with historical earthquakes. In 2011 an earthquake of magnitude Mw 5.2 took place in Lorca (SE Spain) (9 casualties and 460 million Euros in reparations). The study of the EAE's was carried out through the whole city (Giner-Robles et al., 2012). The present study aimed to a.- validate the EAE's methodology using it only in a small place, specifically the cemetery of San Clemente in Lorca, and b.- constraining the range of orientation for each EAE's. This cemetery has been selected because these damage orientation data can be correlated with instrumental information available, and also because this place has: a.- wide variety of architectural styles (neogothic, neobaroque, neoarabian), b.- its Cultural Interest (BIC), and c.- different building materials (brick, limestone, marble). The procedure involved two main phases: a.- inventory and identification of damage (EAE's) by pictures, and b.- analysis of the damage orientations. The orientation was calculated for each EAE's and plotted in maps. Results are NW-SE damage orientation. This orientation is consistent with that recorded in the accelerometer of Lorca (N160°E) and with that obtained from the analysis of EAE's for the whole town of Lorca (N130°E) (Giner-Robles et al., 2012). Due to the existence of an accelerometer, we know the orientation of the peak ground acceleration and we have been able to constrain the ranges of orientation for each EAE's. The orientation of the damage is not usually recorded after an earthquake; however, it can provide information on seismic source in historical earthquakes. References Giner-Robles, J. L., Perez-Lopez, R., Silva Barroso, P., Rodriguez-Pascua, M. A., Martin-Gonzalez, F. and Cabanas, L. 2012. Analisis estructural de danos orientados en el terremoto de Lorca del 11 de mayo de 2011. Aplicaciones en arqueosismologia. Boletín Geológico y Minero, 123 (4): 503-513 Rodriguez-Pascua, M.A., Perez-Lopez, R., Silva, P.G., Giner- Robles, J.L., Garduno-Monroy, V.H. and Reicherter, K. 2011. A Comprehensive Classification of Earthquake Archaeological Effects (EAE) for Archaeoseismology. Quaternary International, 242, 20-30.

Martín-González, Fidel; Martín-Velazquez, Silvia; Rodrigez-Pascua, Miguel Angel; Pérez-López, Raul; Silva, Pablo