Science.gov

Sample records for death linking sister

  1. Meaning of the death of an elderly father: two sisters' perspectives.

    PubMed

    Moss, Miriam S; Moss, Sidney Z

    Multiple bereaved adult children, as siblings, have rarely been studied. We expand the paradigm of bereavement research to explore the ways that two sisters describe the experience and meaning of the death of their elderly father. The two sisters each participated in two separate qualitative ethnographic interviews, followed by standard qualitative analyses of the transcribed narratives. The findings yield contrasting perspectives of the sisters' disparate views of their family, of their father, and their views of each other, that provide insight into the complexity of the sharp differences in their reactions to their father's death. Their views of their father's death reflected their particular relationship with their father, their non-shared experiences over the life course, and their personal world views. Differences and contradictions in the views of multiple siblings can broaden our understanding of bereavement and of the processes central to parent-child ties at the end of life. PMID:23617099

  2. Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

    PubMed Central

    Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M.

    2016-01-01

    During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term ‘bridging fibre', bridges sister k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking sister k-fibres, withstands the tension between sister kinetochores and enables the spindle to obtain a curved shape. PMID:26728792

  3. Tantalizing Thanatos: unexpected links in death pathways.

    PubMed

    Cohen, Isabelle; Castedo, Maria; Kroemer, Guido

    2002-07-01

    Cell death is most frequently the result of apoptosis, an event that is often controlled by mitochondrial membrane permeabilization (MMP). Recent data reveal unexpected functional links between apoptosis and autophagic cell death, in the sense that MMP can trigger autophagy of damaged mitochondria. Conversely, one of the major signal-transducing molecules involved in the activation of autophagy during apoptosis--the so-called DAP kinase--can induce cell death through MMP. Connections are also emerging between apoptosis, autophagy, replicative senescence and cancer-specific metabolic changes. PMID:12185842

  4. Links between sisters' sexual and dating victimization: the roles of neighborhood crime and parental controls.

    PubMed

    East, Patricia L; Chien, Nina C; Adams, Joyce A; Hokoda, Audrey; Maier, Ashley

    2010-12-01

    This study examined the extent to which a sister's prior sexual and dating victimization is a risk factor for young women being similarly victimized and the possible factors underlying a co-occurrence. The sample involved 122 young adult Latina or African American sister pairs (244 women; ages 16-25) who resided in low-income, urban neighborhoods. Results indicated that women whose sisters had been victimized had increased risk of victimization even after controlling for neighborhood crime, parental controls, age and race-ethnicity (odds ratios were 4.0 for unwanted touching, 6.2 for a forced sex act, and 16.7 for dating violence). In high-crime neighborhoods, the presence of two adult parent figures in the home was associated with women's reduced likelihood of unwanted touching, and mothers' high monitoring during adolescence was associated with women's lower risk of dating aggression. Survival analysis results showed that the risk period of a second sister being victimized lasts between 7 and 10 years after a first sister's victimization. The prevention implications of study findings are discussed. PMID:21171768

  5. Sickle Cell Trait Not Linked to Early Death in Study

    MedlinePlus

    ... html Sickle Cell Trait Not Linked to Early Death in Study However, black soldiers with the gene ... cell gene variant, are at risk of premature death. People with the sickle cell gene variant do ...

  6. Cytochrome b Divergence between Avian Sister Species Is Linked to Generation Length and Body Mass

    PubMed Central

    Thomson, Caroline E.; Gilbert, James D. J.; Brooke, M. de L

    2014-01-01

    It is increasingly realised that the molecular clock does not tick at a constant rate. Rather, mitochondrial mutation rates are influenced by factors such as generation length and body mass. This has implications for the use of genetic data in species delimitation. It could be that speciation, as recognised by avian taxonomists, is associated with a certain minimum genetic distance between sister taxa, in which case we would predict no difference in the cytochrome b divergence of sister taxa according to the species' body size or generation time. Alternatively, if what taxonomists recognise as speciation has tended to be associated with the passage of a minimum amount of time since divergence, then there might be less genetic divergence between sister taxa with slower mutation rates, namely those that are heavier and/or with longer generation times. After excluding non-flying species, we analysed a database of over 600 avian sister species pairs, and found that species pairs with longer generation lengths (which tend to be the larger species) showed less cytochrome b divergence. This finding cautions against using any simple unitary criterion of genetic divergence to delimit species. PMID:24505250

  7. Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome.

    PubMed

    Samora, Catarina P; Saksouk, Julie; Goswami, Panchali; Wade, Ben O; Singleton, Martin R; Bates, Paul A; Lengronne, Armelle; Costa, Alessandro; Uhlmann, Frank

    2016-08-01

    DNA replication during S phase is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome segregation. The Eco1 acetyltransferase, helped by factors including Ctf4 and Chl1, concomitantly acetylates the chromosomal cohesin complex to stabilize its cohesive links. Here we show that Ctf4 recruits the Chl1 helicase to the replisome via a conserved interaction motif that Chl1 shares with GINS and polymerase α. We visualize recruitment by EM analysis of a reconstituted Chl1-Ctf4-GINS assembly. The Chl1 helicase facilitates replication fork progression under conditions of nucleotide depletion, partly independently of Ctf4 interaction. Conversely, Ctf4 interaction, but not helicase activity, is required for Chl1's role in sister chromatid cohesion. A physical interaction between Chl1 and the cohesin complex during S phase suggests that Chl1 contacts cohesin to facilitate its acetylation. Our results reveal how Ctf4 forms a replisomal interaction hub that coordinates replication fork progression and sister chromatid cohesion establishment. PMID:27397686

  8. NATIONAL VITAL STATISTICS SYSTEM - LINKED BIRTH AND INFANT DEATH DATA

    EPA Science Inventory

    In 1983, NCHS established a research data set comprised of linked birth and death certificates for infants born in the United States who died before reaching one year of age. In this data set, information from the death certificate is linked with information from the birth certif...

  9. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

    PubMed

    Seitan, Vlad C; Banks, Peter; Laval, Steve; Majid, Nazia A; Dorsett, Dale; Rana, Amer; Smith, Jim; Bateman, Alex; Krpic, Sanja; Hostert, Arnd; Rollins, Robert A; Erdjument-Bromage, Hediye; Tempst, Paul; Benard, Claire Y; Hekimi, Siegfried; Newbury, Sarah F; Strachan, Tom

    2006-07-01

    Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein-protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious sister chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that sister chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development. PMID:16802858

  10. Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance

    PubMed Central

    Seitan, Vlad C; Banks, Peter; Laval, Steve; Majid, Nazia A; Dorsett, Dale; Rana, Amer; Smith, Jim; Bateman, Alex; Krpic, Sanja; Hostert, Arnd; Rollins, Robert A; Erdjument-Bromage, Hediye; Tempst, Paul; Benard, Claire Y; Hekimi, Siegfried; Newbury, Sarah F

    2006-01-01

    Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein–protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious sister chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that sister chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development. PMID:16802858

  11. SISTER STUDY

    EPA Science Inventory

    The Sister Study will investigate the role of genetic, environmental, and lifestyle factors on the risk of breast cancer and other diseases in sisters of women with breast cancer. This research study will enroll 50,000 women who live in the United States and who are the cancer-fr...

  12. Correlations of blood lead with DNA-protein cross-links and sister chromatid exchanges in lead workers.

    PubMed

    Wu, Fang-Yang; Chang, Pao-Wen; Wu, Chin-Ching; Kuo, Hsien-Wen

    2002-03-01

    Levels of sister chromatid exchanges (SCEs), high-SCE frequency cells (HFCs), DNA-protein cross-links (DPCs), blood lead (BLL), and zinc protoporphyrin (ZPP) were measured in peripheral blood from three groups. The lead workers were divided into two groups: a high BLL group (> or =15 microg/dl) and a low BLL group (<15 microg/dl). The control subjects were selected from an area that had not been contaminated with lead and had normal BLL and ZPP levels. In addition, exposure to airborne lead was measured for 11 lead workers, and the time-weighted average was shown to range from 0.19 to 10.32 mg/m(3). The BLL levels of 9 of 11 workers were >15 microg/dl, of which, 3 exceeded current exposure limits (> or =40 microg/dl). The BLL levels of all 11 controls were < 15 microg/dl. The average SCE and DPC values for the workers were 6.1 SCEs/cell and 1.9%, which were significantly higher (P < 0.01, Wilcoxon's test) than the value of 5.2 SCEs/cell and 1.1% for the control subjects. Lead workers had significantly higher BLL and ZPP levels than did the controls. Statistically significant increases in DPCs, SCEs, and HFCs were observed for the high-BLL group compared with the control group. The results of this study suggest that DPCs, SCEs, and HFCs are reliable biomarkers for monitoring workers exposed to lead and clearly indicate health effects from occupational exposure to lead. PMID:11895879

  13. One Sister's Story

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues One Sister's Story Past Issues / Fall 2006 Table of ... NIH/NIEHS By Tina Hall Sister Study participant One day in April, after my sister returned from ...

  14. Goddard Welcomes SISTER

    NASA Video Gallery

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  15. Embryonic Death Is Linked to Maternal Identity in the Leatherback Turtle (Dermochelys coriacea)

    PubMed Central

    Rafferty, Anthony R.; Santidrián Tomillo, Pilar; Spotila, James R.; Paladino, Frank V.; Reina, Richard D.

    2011-01-01

    Leatherback turtles have an average global hatching success rate of ∼50%, lower than other marine turtle species. Embryonic death has been linked to environmental factors such as precipitation and temperature, although, there is still a lot of variability that remains to be explained. We examined how nesting season, the time of nesting each season, the relative position of each clutch laid by each female each season, maternal identity and associated factors such as reproductive experience of the female (new nester versus remigrant) and period of egg retention between clutches (interclutch interval) affected hatching success and stage of embryonic death in failed eggs of leatherback turtles nesting at Playa Grande, Costa Rica. Data were collected during five nesting seasons from 2004/05 to 2008/09. Mean hatching success was 50.4%. Nesting season significantly influenced hatching success in addition to early and late stage embryonic death. Neither clutch position nor nesting time during the season had a significant affect on hatching success or the stage of embryonic death. Some leatherback females consistently produced nests with higher hatching success rates than others. Remigrant females arrived earlier to nest, produced more clutches and had higher rates of hatching success than new nesters. Reproductive experience did not affect stage of death or the duration of the interclutch interval. The length of interclutch interval had a significant affect on the proportion of eggs that failed in each clutch and the developmental stage they died at. Intrinsic factors such as maternal identity are playing a role in affecting embryonic death in the leatherback turtle. PMID:21695086

  16. Birth and death of links control disease spreading in empirical contact networks

    NASA Astrophysics Data System (ADS)

    Holme, Petter; Liljeros, Fredrik

    2014-05-01

    We investigate what structural aspects of a collection of twelve empirical temporal networks of human contacts are important to disease spreading. We scan the entire parameter spaces of the two canonical models of infectious disease epidemiology--the Susceptible-Infectious-Susceptible (SIS) and Susceptible-Infectious-Removed (SIR) models. The results from these simulations are compared to reference data where we eliminate structures in the interevent intervals, the time to the first contact in the data, or the time from the last contact to the end of the sampling. The picture we find is that the birth and death of links, and the total number of contacts over a link, are essential to predict outbreaks. On the other hand, the exact times of contacts between the beginning and end, or the interevent interval distribution, do not matter much. In other words, a simplified picture of these empirical data sets that suffices for epidemiological purposes is that links are born, is active with some intensity, and die.

  17. The Prodigal Sister - Venus

    NASA Astrophysics Data System (ADS)

    Barlow, Nadine G.

    1995-09-01

    If you think Venus is a hellhole now, be thankful you weren't there 500 million years ago. Those were the days, many planetary scientists believe, of apocalypse on our sister world: Volcanoes wracked the land, while greenhouse gases broiled the air. Is this the Earth's fate, too?

  18. Wallerian degeneration: an emerging axon death pathway linking injury and disease.

    PubMed

    Conforti, Laura; Gilley, Jonathan; Coleman, Michael P

    2014-06-01

    Axon degeneration is a prominent early feature of most neurodegenerative disorders and can also be induced directly by nerve injury in a process known as Wallerian degeneration. The discovery of genetic mutations that delay Wallerian degeneration has provided insight into mechanisms underlying axon degeneration in disease. Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1 and PHR1. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration, whereas NMNAT overexpression rescues axons from degeneration. Here, we discuss the roles of these and other proposed regulators of Wallerian degeneration, new opportunities for understanding disease mechanisms and intriguing links between Wallerian degeneration, innate immunity, synaptic growth and cell death. PMID:24840802

  19. Big Sisters: An Experimental Evaluation.

    ERIC Educational Resources Information Center

    Seidl, Fredrick W.

    1982-01-01

    Assessed the effects of participation in a Big Sisters' Program. The first part consisted of interviews (N=20) with pairs of Big Sisters-Little Sisters. The second part evaluated program effectiveness experimentally. Findings indicated positive relationships between pairs, and improved behavior of experimental girls versus controls. (RC)

  20. Veterans and Suicide: A Reexamination of the National Death Index–Linked National Health Interview Survey

    PubMed Central

    Barber, Catherine; Young, Melissa; Azrael, Deborah; Mukamal, Kenneth; Lawler, Elizabeth

    2012-01-01

    Objectives. We assessed the risk of suicide among veterans compared with nonveterans. Methods. Cox proportional hazards models estimated the relative risk of suicide, by self-reported veteran status, among 500 822 adult male participants in the National Death Index (NDI)–linked National Health Interview Survey (NHIS), a nationally representative cohort study. Results. A total of 482 male veterans died by suicide during 1 837 886 person-years of follow-up (76% by firearm); 835 male nonveterans died by suicide during 4 438 515 person-years of follow-up (62% by firearm). Crude suicide rates for veterans and nonveterans were, respectively, 26.2 and 18.8 per 100 000 person-years. The risk of suicide was not significantly higher among veterans, compared with nonveterans, after adjustment for differences in age, race, and survey year (hazard ratio = 1.11; 95% confidence interval = 0.96, 1.29). Conclusions. Consistent with most studies of suicide risk among veterans of conflicts before Operation Iraqi Freedom/Operation Enduring Freedom, but in contrast to a previous study using the NDI-linked NHIS data, we found that male veterans responding to the NHIS were modestly, but not significantly, at higher risk for suicide compared with male nonveterans. PMID:22390591

  1. B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of Fas-associated death domain protein.

    PubMed

    Besnault, L; Schrantz, N; Auffredou, M T; Leca, G; Bourgeade, M F; Vazquez, A

    2001-07-15

    We have previously reported that B cell receptors, depending on the degree to which they are cross-linked, can promote apoptosis in various human B cell types. In this study, we show that B cell receptors can trigger two apoptotic pathways according to cross-linking and that these pathways control mitochondrial activation in human Burkitt's lymphoma cells. Whereas soluble anti-mu Ab triggers caspase-independent mitochondrial activation, cross-linked anti-mu Ab induces an apoptotic response associated with a caspase-dependent loss of mitochondrial transmembrane potential. This B cell receptor-mediated caspase-dependent mitochondrial activation is associated with caspase-8 activation. We show here that caspase-8 inhibitors strongly decrease cross-linking-dependent B cell receptor-mediated apoptosis in Burkitt's lymphoma BL41 cells. These inhibitors act upstream from the mitochondria as they prevented the loss of mitochondrial membrane potential observed in B cell receptor-treated BL41 cells. Caspase-8 activation in these cells was also evident from the detection of cleaved fragments of caspase-8 and the cleavage of specific substrates, including Bid. Our data show that cross-linked B cell receptors induced an apoptotic pathway involving sequential caspase-8 activation, loss of mitochondrial membrane potential, and the activation of caspase-9 and caspase-3. Cells expressing a dominant negative mutant of Fas-associated death domain protein were sensitive to cross-linked B cell receptor-induced caspase-8 activation and apoptosis; therefore, this caspase-8 activation was independent of the death effector domain of Fas-associated death domain protein. PMID:11441077

  2. Community-linked maternal death review (CLMDR) to measure and prevent maternal mortality: a pilot study in rural Malawi

    PubMed Central

    Bayley, Olivia; Chapota, Hilda; Kainja, Esther; Phiri, Tambosi; Gondwe, Chelmsford; King, Carina; Nambiar, Bejoy; Mwansambo, Charles; Kazembe, Peter; Costello, Anthony; Rosato, Mikey

    2015-01-01

    Background In Malawi, maternal mortality remains high. Existing maternal death reviews fail to adequately review most deaths, or capture those that occur outside the health system. We assessed the value of community involvement to improve capture and response to community maternal deaths. Methods We designed and piloted a community-linked maternal death review (CLMDR) process in Mchinji District, Malawi, which partnered community and health facility stakeholders to identify and review maternal deaths and generate actions to prevent future deaths. The CLMDR process involved five stages: community verbal autopsy, community and facility review meetings, a public meeting and bimonthly reviews involving both community and facility representatives. Results The CLMDR process was found to be comparable to a previous research-driven surveillance system at identifying deaths in Mchinji District (population 456 500 in 2008). 52 maternal deaths were identified between July 2011 and June 2012, 27 (52%) of which would not have been identified without community involvement. Based on district estimates of population (500 000) and crude birth rate (35 births per 1000 population), the maternal mortality ratio was around 300 maternal deaths per 100 000 live births. Of the 41 cases that started the CLMDR process, 28 (68%) completed all five stages. We found the CLMDR process to increase the quantity of information available and to involve a wider range of stakeholders in maternal death review (MDR). The process resulted in high rates of completion of community-planned actions (82%), and district hospital (67%) and health centre (65%) actions to prevent maternal deaths. Conclusions CLMDR is an important addition to the established forms of MDR. It shows potential as a maternal death surveillance system, and may be applicable to similar contexts with high maternal mortality. PMID:25897028

  3. A possible link between life and death of a xeric tree in desert.

    PubMed

    Xu, Gui-Qing; McDowell, Nate G; Li, Yan

    2016-05-01

    Understanding the interactions between drought and tree ontogeny or size remains an essential research priority because size-specific mortality patterns have large impacts on ecosystem structure and function, determine forest carbon storage capacity, and are sensitive to climatic change. Here we investigate a xerophytic tree species (Haloxylon ammodendron (C.A. Mey.)) with which the changes in biomass allocation with tree size may play an important role in size-specific mortality patterns. Size-related changes in biomass allocation, root distribution, plant water status, gas exchange, hydraulic architecture and non-structural carbohydrate reserves of this xerophytic tree species were investigated to assess their potential role in the observed U-shaped mortality pattern. We found that excessively negative water potentials (<-4.7MPa, beyond the P50leaf of -4.1MPa) during prolonged drought in young trees lead to hydraulic failure; while the imbalance of photoassimilate allocation between leaf and root system in larger trees, accompanied with declining C reserves (<2% dry matter across four tissues), might have led to carbon starvation. The drought-resistance strategy of this species is preferential biomass allocation to the roots to improve water capture. In young trees, the drought-resistance strategy is not well developed, and hydraulic failure appears to be the dominant driver of mortality during drought. With old trees, excess root growth at the expense of leaf area may lead to carbon starvation during prolonged drought. Our results suggest that the drought-resistance strategy of this xeric tree is closely linked to its life and death: well-developed drought-resistance strategy means life, while underdeveloped or overdeveloped drought-resistance strategy means death. PMID:26968083

  4. Linking families and facilities for care at birth: What works to avert intrapartum-related deaths?

    PubMed Central

    Lee, Anne CC; Lawn, Joy E.; Cousens, Simon; Kumar, Vishwajeet; Osrin, David; Bhutta, Zulfiqar A.; Wall, Steven N.; Nandakumar, Allyala K.; Syed, Uzma; Darmstadt, Gary L.

    2012-01-01

    Background Delays in receiving effective care during labor and at birth may be fatal for the mother and fetus, contributing to 2 million annual intrapartum stillbirths and intrapartum-related neonatal deaths each year. Objective We present a systematic review of strategies to link families and facilities, including community mobilization, financial incentives, emergency referral and transport systems, prenatal risk screening, and maternity waiting homes. Results There is moderate quality evidence that community mobilization with high levels of community engagement can increase institutional births and significantly reduce perinatal and early neonatal mortality. Meta-analysis showed a doubling of skilled birth attendance and a 35% reduction in early neonatal mortality. However, no data are available on intrapartum-specific outcomes. Evidence is limited, but promising, that financial incentive schemes and community referral/transport systems may increase rates of skilled birth attendance and emergency obstetric care utilization; however, impact on mortality is unknown. Current evidence for maternity waiting homes and risk screening is low quality. Conclusions Empowering communities is an important strategy to reduce the large burden of intrapartum complications. Innovations are needed to bring the poor closer to obstetric care, such as financial incentives and cell phone technology. New questions need to be asked of “old” strategies such as risk screening and maternity waiting homes. The effect of all of these strategies on maternal and perinatal mortality, particularly intrapartum-related outcomes, requires further evaluation. PMID:19815201

  5. Sister-sister incest: data from an anonymous computerized survey.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims. PMID:23924178

  6. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice.

    PubMed

    Petrik, Michael S; Wong, Margaret C; Tabata, Rena C; Garry, Robert F; Shaw, Christopher A

    2007-01-01

    Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny. Among the vaccine's potentially toxic components are the adjuvants aluminum hydroxide and squalene. To examine whether these compounds might contribute to neuronal deficits associated with GWI, an animal model for examining the potential neurological impact of aluminum hydroxide, squalene, or aluminum hydroxide combined with squalene was developed. Young, male colony CD-1 mice were injected with the adjuvants at doses equivalent to those given to US military service personnel. All mice were subjected to a battery of motor and cognitive-behavioral tests over a 6-mo period postinjections. Following sacrifice, central nervous system tissues were examined using immunohistochemistry for evidence of inflammation and cell death. Behavioral testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured by the wire-mesh hang test (final deficit at 24 wk; about 50%). Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group (4.3 errors per trial) compared with the controls (0.2 errors per trial) after 20 wk. Apoptotic neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord. The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an

  7. On the feasibility of linking census samples to the National Death Index for epidemiologic studies: a progress report.

    PubMed

    Rogot, E; Feinleib, M; Ockay, K A; Schwartz, S H; Bilgrad, R; Patterson, J E

    1983-11-01

    To test the feasibility of using large national probability samples provided by the US Census Bureau, a pilot project was initiated to link 230,000 Census-type records to the National Death Index (NDI). Using strict precautions to maintain the complete confidentiality of individual records, the Current Population Survey files of one month in 1973 and one month in 1978 were matched by computer to the 1979 NDI file. The basic question to be addressed was whether deaths so obtained are seriously underestimated when there is no Social Security Number (SSN) in the Census record. The search of the NDI file resulted in 5,542 matches of which about 1,800 appear to be "true positives" representing deaths, the remainder are "false positives." Of the deaths, 80 per cent would still have been detected without SSN in the Census record. The main reasons for missing deaths (false negatives) were discrepancies in the year of birth and in the given name. Assuming certain changes in the NDI matching algorithm, the 80 per cent figure could increase to 85 per cent or higher; however, this could also cause significant increases in the number of false positives. The National Heart, Lung and Blood Institute (NHLBI) and Census Bureau staff are currently developing a probabilistic method to eliminate false positives from the NDI output tape. The results of the pilot study indicate that a larger research project is clearly feasible. PMID:6625029

  8. Where are Sedna's Sisters?

    NASA Astrophysics Data System (ADS)

    Bartlett, D. F.

    2005-05-01

    Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

  9. Evidence links increases in public health spending to declines in preventable deaths.

    PubMed

    Mays, Glen P; Smith, Sharla A

    2011-08-01

    Public health encompasses a broad array of programs designed to prevent the occurrence of disease and injury within communities. But policy makers have little evidence to draw on when determining the value of investments in these program activities, which currently account for less than 5 percent of US health spending. We examine whether changes in spending by local public health agencies over a thirteen-year period contributed to changes in rates of community mortality from preventable causes of death, including infant mortality and deaths due to cardiovascular disease, diabetes, and cancer. We found that mortality rates fell between 1.1 percent and 6.9 percent for each 10 percent increase in local public health spending. These results suggest that increased public health investments can produce measurable improvements in health, especially in low-resource communities. However, more money by itself is unlikely to generate significant and sustainable health gains; improvements in public health practices are needed as well. PMID:21778174

  10. Neuromyelitis optica in Japanese sisters.

    PubMed

    Tanaka, Yuji; Yoshikura, Nobuaki; Harada, Naoko; Yamada, Megumi; Koumura, Akihiro; Sakurai, Takeo; Hayashi, Yuichi; Kimura, Akio; Hozumi, Isao; Moriwaki, Hisataka; Inuzuka, Takashi

    2011-01-01

    We report cases of Japanese sisters with neuromyelitis optica (NMO). The elder sister was 25, when she was diagnosed with right optic neuritis. After 3 months, she developed left optic neuritis and myelitis. At age 27, she had the second relapse, but she has been free from episodes thereafter. The younger sister was 26, when she was diagnosed with optic neuritis. Thus far, she has 9 relapses, comprising both myelitis and optic neuritis. Both sisters had normal brain MRI scans, longitudinally extensive transverse myelitis over 3 vertebral segments, and positive results for anti-aquaporin-4 antibody (AQAP4Ab). They fulfilled the Wingerchuk criteria for definite NMO. Both sisters shared some immunogenetic factors, but they were not exposed to the same environmental factors after their early twenties. The final disability status was almost the same in both cases, and both showed a very benign course. These data suggest that genetic factors affect the age at onset and environmental factors may affect the frequency of relapse. PMID:22082898

  11. Investigations into the Mechanisms of Cell Death: The Common Link between Anticancer Nanotherapeutics and Nanotoxicology

    NASA Astrophysics Data System (ADS)

    Minocha, Shalini

    Nanotoxicology and anticancer nanotherapeutics are essentially two sides of the same coin. The nanotoxicology discipline deals with the nanoparticle (NP)-induced toxicity and mechanisms of cell death in healthy cells, whereas anticancer agents delivered via nano-based approaches aim to induce cell death in abnormally proliferating cancer cells. The objectives of the studies presented herein were two-fold; to (a) systematically study the physico-chemical properties and cell death mechanisms of model NPs and (b) utilize the knowledge gained from cell death-nanotoxicity studies in developing a potentially novel anticancer nanotherapeutic agent. For the first objective, the effect of a distinguishing characteristic, i.e., surface carbon coating on the matched pairs of carbon-coated and non-coated copper and nickel NPs (Cu, C-Cu, Ni and C-Ni) on the physico-chemical properties and toxicity in A549 alveolar epithelial cells were evaluated. The effect of carbon coating on particle size, zeta potential, oxidation state, cellular uptake, release of soluble metal and concentration dependent toxicity of Cu and Ni NPs was systematically evaluated. A significant effect of carbon coating was observed on the physico-chemical properties, interaction with cellular membranes, and overall toxicity of the NPs. C-Cu NPs, compared to Cu NPs, showed four-fold lower release of soluble copper, ten-fold higher cellular uptake and protection against surface oxidation. In toxicity assays, C-Cu NPs induced higher mitochondrial damage than Cu NPs whereas Cu NPs were associated with a significant damage to plasma membrane integrity. Nickel and carbon coated nickel NPs were less toxic compared to Cu and C-Cu NPs. Thus, by studying the effect of carbon coating, correlations between physico-chemical properties and toxicity of NPs were established. The second objective was focused on utilizing nano-based approaches for the intracellular delivery of an anticancer agent, Cytochrome c (Cyt c), to

  12. Linking pattern recognition and salicylic acid responses in Arabidopsis through ACCELERATED CELL DEATH6 and receptors

    PubMed Central

    Tateda, Chika; Zhang, Zhongqin; Greenberg, Jean T

    2015-01-01

    The Arabidopsis membrane protein ACCELERATED CELL DEATH 6 (ACD6) and the defense signal salicylic acid (SA) are part of a positive feedback loop that regulates the levels of at least 2 pathogen-associated molecular patterns (PAMP) receptors, including FLAGELLIN SENSING 2 (FLS2) and CHITIN ELICITOR RECEPTOR (LYSM domain receptor-like kinase 1, CERK1). ACD6- and SA-mediated regulation of these receptors results in potentiation of responses to FLS2 and CERK1 ligands (e.g. flg22 and chitin, respectively). ACD6, FLS2 and CERK1 are also important for callose induction in response to an SA agonist even in the absence of PAMPs. Here, we report that another receptor, EF-Tu RECEPTOR (EFR) is also part of the ACD6/SA signaling network, similar to FLS2 and CERK1. PMID:26442718

  13. Weather and Death on Mount Everest: Is there a link between Storms and Human Physiology?

    NASA Astrophysics Data System (ADS)

    Moore, K.; Semple, J.

    2004-05-01

    Scientific interest in Mount Everest has been largely focused on the hypoxia caused by the summit's low barometric pressure. Although weather is recognized as a significant risk factor, it has not been extensively studied. Through the use of observations made at the mountain's South Col, elevation 7986m, and other datasets, we show that high impact weather events on Mount Everest, including the May 1996 storm in which 8 climbers perished, are often associated with continental-scale intrusions of stratospheric air into the upper-troposphere. The variability in wind speeds associated with these intrusions triggered convective activity that resulted in the high impact weather. In addition, the validation of existing meteorological data allows for useful insights into the possibility of forecasting these high impact weather events and their physiological impacts thereby mitigating deaths that occur on the exposed upper slopes of Mount Everest.

  14. Sudden infant death syndrome and placental disorders: the thyroid-selenium link.

    PubMed

    Reid, G M; Tervit, H

    1997-04-01

    Placental insufficiency, inducing hypoxia-ischaemia, is considered a major cause of neuronal injury and impaired post natal development. Placental insufficiency alters the metabolism of arachidonic acid and its oxidation products. Premature labour and low-birth-weight infants are associated with reduced intrauterine blood-flow and infections of the reproductive tract. Thyroidal activity is depressed in undernutrition (placental insufficiency). Premature infants require extra vitamin C for normal tyrosine metabolism (tyrosine is the thyroxine precursor). Among the symptoms indicating infantile cretinism, which appear during 3-5 months of age are: delayed union of skull bones, torpid behaviour, slow feeding, cyanosis during feeding, excessive sleepiness, enlarged tongue, umbilical herniation, flabby musculature, short stature and delayed development. These symptoms have all been described in low-birth-weight infants and sudden infant death syndrome victims by various authors. Bacteria utilize selenium (at the expense of host tissue). Escherichia coli is among the bacteria invading the reproductive tract. E. coli produce thiouracil and are goitrogenic. Some strains of E. coli produce phospholipase A2 which releases arachidonic acid from phospholipids for prostaglandin synthesis. Phospholipase A2 is more active against peroxidized than non-peroxidized lipids. Bacterial competition for intrauterine selenium and goitrogenic bacterial infections of the reproductive tract during pregnancy, depress thyroid function in the fetus but not in the mother. PMID:9160285

  15. The Shannoniella sisters (Diptera: Rhinophoridae).

    PubMed

    Nihei, Silvio S; Andrade, Marcos R; Pape, Thomas; Cerretti, Pierfilippo

    2016-01-01

    Shannoniella cuspidata Townsend, 1939 is redescribed and S. setinervis sp. nov. (Brazil, State of Rio de Janeiro) is newly described as its putative sister taxon, thereby allowing for a strict definition of the genus Shannoniella Townsend, 1939 through explicit synapomorphies. An identification key is provided. PMID:27395483

  16. All in the Family: The Sister Study

    MedlinePlus

    ... Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / Fall 2006 Table of ... in their daily lives. Want to Volunteer for the Sister Study? To volunteer or learn more about ...

  17. Novel Insights into the Molecular Events Linking to Cell Death Induced by Tetracycline in the Amitochondriate Protozoan Trichomonas vaginalis

    PubMed Central

    Huang, Kuo-Yang; Ku, Fu-Man; Cheng, Wei-Hung; Lee, Chi-Ching; Huang, Po-Jung; Chu, Lichieh Julie; Cheng, Chih-Chieh; Fang, Yi-Kai; Wu, Hsueh-Hsia

    2015-01-01

    Trichomonas vaginalis colonizes the human urogenital tract and causes trichomoniasis, the most common nonviral sexually transmitted disease. Currently, 5-nitroimidazoles are the only recommended drugs for treating trichomoniasis. However, increased resistance of the parasite to 5-nitroimidazoles has emerged as a highly problematic public health issue. Hence, it is essential to identify alternative chemotherapeutic agents against refractory trichomoniasis. Tetracycline (TET) is a broad-spectrum antibiotic with activity against several protozoan parasites, but the mode of action of TET in parasites remains poorly understood. The in vitro effect of TET on the growth of T. vaginalis was examined, and the mode of cell death was verified by various apoptosis-related assays. Next-generation sequencing-based RNA sequencing (RNA-seq) was employed to elucidate the transcriptome of T. vaginalis in response to TET. We show that TET has a cytotoxic effect on both metronidazole (MTZ)-sensitive and -resistant T. vaginalis isolates, inducing some features resembling apoptosis. RNA-seq data reveal that TET significantly alters the transcriptome via activation of specific pathways, such as aminoacyl-tRNA synthetases and carbohydrate metabolism. Functional analyses demonstrate that TET disrupts the hydrogenosomal membrane potential and antioxidant system, which concomitantly elicits a metabolic shift toward glycolysis, suggesting that the hydrogenosomal function is impaired and triggers cell death. Collectively, we provide in vitro evidence that TET is a potential alternative therapeutic choice for treating MTZ-resistant T. vaginalis. The in-depth transcriptomic signatures in T. vaginalis upon TET treatment presented here will shed light on the signaling pathways linking to cell death in amitochondriate organisms. PMID:26303799

  18. Nonzero-temperature entanglement negativity of quantum spin models: Area law, linked cluster expansions, and sudden death.

    PubMed

    Sherman, Nicholas E; Devakul, Trithep; Hastings, Matthew B; Singh, Rajiv R P

    2016-02-01

    We show that the bipartite logarithmic entanglement negativity (EN) of quantum spin models obeys an area law at all nonzero temperatures. We develop numerical linked cluster (NLC) expansions for the "area-law" logarithmic entanglement negativity as a function of temperature and other parameters. For one-dimensional models the results of NLC are compared with exact diagonalization on finite systems and are found to agree very well. The NLC results are also obtained for two dimensional XXZ and transverse field Ising models. In all cases, we find a sudden onset (or sudden death) of negativity at a finite temperature above which the negativity is zero. We use perturbation theory to develop a physical picture for this sudden onset (or sudden death). The onset of EN or its magnitude are insensitive to classical finite-temperature phase transitions, supporting the argument for absence of any role of quantum mechanics at such transitions. On approach to a quantum critical point at T=0, negativity shows critical scaling in size and temperature. PMID:26986309

  19. Nonzero-temperature entanglement negativity of quantum spin models: Area law, linked cluster expansions, and sudden death

    NASA Astrophysics Data System (ADS)

    Sherman, Nicholas E.; Devakul, Trithep; Hastings, Matthew B.; Singh, Rajiv R. P.

    2016-02-01

    We show that the bipartite logarithmic entanglement negativity (EN) of quantum spin models obeys an area law at all nonzero temperatures. We develop numerical linked cluster (NLC) expansions for the "area-law" logarithmic entanglement negativity as a function of temperature and other parameters. For one-dimensional models the results of NLC are compared with exact diagonalization on finite systems and are found to agree very well. The NLC results are also obtained for two dimensional X X Z and transverse field Ising models. In all cases, we find a sudden onset (or sudden death) of negativity at a finite temperature above which the negativity is zero. We use perturbation theory to develop a physical picture for this sudden onset (or sudden death). The onset of EN or its magnitude are insensitive to classical finite-temperature phase transitions, supporting the argument for absence of any role of quantum mechanics at such transitions. On approach to a quantum critical point at T =0 , negativity shows critical scaling in size and temperature.

  20. A Brief Analysis of Sister Carrie's Character

    ERIC Educational Resources Information Center

    Yu, Hanying

    2010-01-01

    Carrie is always dreaming while the rocking chair is rocking again and again, this is the deep impression on us after we read "Sister Carrie" which is the first novel of Theodore Dreiser. In this novel the protagonist Sister Carrie is a controversial person. This paper tries to analyze the character of Sister Carrie in order to find out…

  1. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor" in which…

  2. Two Sisters with Rett Syndrome. Brief Report.

    ERIC Educational Resources Information Center

    Haenggeli, Charles A.; And Others

    1990-01-01

    Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

  3. EarthLabs Meet Sister Corita Kent

    NASA Astrophysics Data System (ADS)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  4. Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein

    SciTech Connect

    Steen, Hakan; Lindholm, Dan

    2008-02-08

    Nuclear localized protein-1 (Nulp1) is a recently identified gene expressed in mouse and human tissues particularly during embryonic development. Nulp1 belongs to the family of basic helix-loop-helix (bHLH) proteins that are important in development. The precise function of Nulp1 in cells is however not known. We observed that overexpression of Nulp1 induces a large increase in cell death of human osteosarcoma Saos2 cells with DNA fragmentation. In mouse N2A neuroblastoma cells Nulp1 affected cell proliferation and sensitized cells towards death induced by staurosporine. Staining using a novel antibody localized Nulp1 mainly to the cell nucleus and to some extent to the cytoplasm. Nulp1 binds the X-linked inhibitor of apoptosis protein (XIAP) and this interaction was increased during cell death. These results indicate that Nulp1 plays a role in cell death control and may influence tumor growth.

  5. 78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ...The Coast Guard is establishing a temporary safety zone on Sister Bay near Sister Bay, WI. This safety zone is intended to restrict vessels from a portion of Sister Bay due to a fireworks display and ski show. This temporary safety zone is necessary to protect the surrounding public and vessels from the hazards associated with the fireworks display and ski show in Sister Bay on August 31,...

  6. The sister bonding of duplicated chromosomes

    PubMed Central

    Zou, Hui

    2011-01-01

    Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed. PMID:21497666

  7. Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis.

    PubMed

    Lenhausen, Audrey M; Wilkinson, Amanda S; Lewis, Eric M; Dailey, Kaitlin M; Scott, Andrew J; Khan, Shahzeb; Wilkinson, John C

    2016-06-14

    Apoptosis inducing factor (AIF) plays a well-defined role in controlling cell death but is also a critical factor for maintaining mitochondrial energy homeostasis; how these dueling activities are balanced has remained largely elusive. To identify new AIF binding partners that may define the continuum of AIF cellular regulation, a biochemical screen was performed that identified the mitochondrial phosphoglycerate mutase 5 (PGAM5) as an AIF associated factor. AIF binds both the short and long isoforms of PGAM5 and can reduce the ability of PGAM5 to control antioxidant responses. Transient overexpression of either PGAM5 isoform triggers caspase activation and cell death, and while AIF could reduce this caspase activation neither AIF expression nor caspase activity is required for PGAM5-mediated death. PGAM5 toxicity morphologically and biochemically resembles mitophagic cell death and is inhibited by the AIF binding protein X-linked inhibitor of apoptosis (XIAP) in a manner that depends on the ubiquitin ligase activity of XIAP. The phosphatase activity of PGAM5 was not required for cell death, and comparison of phosphatase activity between short and long PGAM5 isoforms suggested that only the long isoform is catalytically competent. This property correlated with an increased ability of PGAM5L to form dimers and/or higher order oligomers in intact cells compared to PGAM5S. Overall this study identifies an AIF/PGAM5/XIAP axis that can regulate PGAM5 activities related to the antioxidant response and mitophagy. PMID:27218139

  8. Creating Sister Cities: An Exchange Across Hemispheres

    NASA Astrophysics Data System (ADS)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  9. When Your Brother or Sister Has Cancer

    Cancer.gov

    Tips on what to say to your friends, how to deal with stress, and where to find support – as well as information about cancer and cancer treatments, for young people who have a brother or sister with cancer.

  10. All in the Family: The Sister Study

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

  11. Eruptive history of South Sister, Oregon Cascades

    USGS Publications Warehouse

    Fierstein, J.; Hildreth, W.; Calvert, A.T.

    2011-01-01

    South Sister is southernmost and highest of the Three Sisters, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North Sister is a monotonously mafic edifice as old as middle Pleistocene, Middle Sister a basalt-andesite-dacite cone built between 48 and 14ka, and South Sister is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle Sister). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South Sister lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South Sister - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South Sister's flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the

  12. [Two Dutch sisters in analysis with Freud].

    PubMed

    Stroeken, Harry

    2010-01-01

    The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two sisters, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger sister to seek divorce. PMID:20503771

  13. "If I only touch her cloak": the Sisters of Charity of St. Joseph in New Orleans hospital, 1834-1860.

    PubMed

    Kong, Hyejung Grace; Kim, Ock-Joo

    2015-04-01

    wearing a distinctive religious garment, they eschewed female dependence and sexuality. As medical and religious attendants at the sick wards, the sisters played a vital role in preparing the patients for a "good death" as well as spiritual wellness. By waging their own war on the Protestant influences, the sisters did their best to build their own sacred place in caring for sick bodies and saving souls. Through the research on the Sisters of Charity at Charity Hospital, this study ultimately sheds light on the ways in which a nineteenth-century southern hospital functioned as a unique environment for the recovery of wellness of the body and soul, shaped and envisioned by the Catholic sister-nurses' gender and religious identities. PMID:25985782

  14. Perceptions of "Big Sisters" and Their "Little Sisters" Regarding Mentoring Relationships

    ERIC Educational Resources Information Center

    Quarles, Alice; Maldonado, Nancy L.; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    This qualitative study explored the relationships between six Little Sisters (mentees) and their Big Sisters (mentors) to develop an understanding of the perceptions of high-risk adolescent female mentees and their mentors regarding their mentoring relationships. Participants were purposefully selected--those actively involved in a formal…

  15. [Wilson-Konovalov disease in 3 sisters: a radical change in prognosis if timely diagnosed].

    PubMed

    Rozina, T P; Ignatova, T M; Solov'eva, O V

    2014-01-01

    Wilson-Konovalov disease is a rare autosomal recessive genetic disorder in which copper accumulates in the liver, brain and other target organs. The paper describes a family case of the abdominal form of the disease in three sisters, the eldest of them died from fulminant liver failure at the age of 18 years. The second sister aged 16 years was diagnosed as having the disease at the stage of decompensated liver cirrhosis; her treatment with D-penicillamine resulted in complete disease remission. The youngest sister was diagnosed with the disease at the preclinical stage, which could expect its good prognosis. However, the patient's refusal of treatment led to death from liver failure. This case demonstrates the importance of timely diagnosis and the possibility of dramatic improvement in prognosis even at the stage of decompensated liver cirrhosis. PMID:24864473

  16. SISTER CHROMATID EXCHANGES IN MAMMALIAN MEIOTIC CHROMOSOMES

    EPA Science Inventory

    Very little is known about sister chromatid exchanges (SCEs) in meiotic cells--only that they occur (1) and reveal frequency and distribution patterns apparently unaffected by cross-over (CO) exchange conditions in those cells; (2) unfortunately, the number of studies from which ...

  17. Sisters at Work: Career and Community Changes.

    ERIC Educational Resources Information Center

    Briody, Elizabeth K.; Sullivan, Teresa A.

    1988-01-01

    The authors examine occupational differentiation of U.S. Catholic nuns before and since the Second Vatican Council. Data were collected from interviews with 30 sisters representing 11 congregations. The analysis relates the diversification of their careers to changes in ideology and life-style and to the changing demographic and financial status…

  18. Mechanics of Sister Chromatids studied with a Polymer Model English</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Yang; Isbaner, Sebastian; Heermann, Dieter</p> <p>2013-10-01</p> <p><span class="hlt">Sister</span> chromatid cohesion denotes the phenomenon that <span class="hlt">sister</span> chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain <span class="hlt">sister</span> chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of <span class="hlt">sister</span> chromatids by means of computer simulations. We model both protein-mediated cohesion between <span class="hlt">sister</span> chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific <span class="hlt">link</span> concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=crocodile&pg=3&id=EJ537653','ERIC'); return false;" href="http://eric.ed.gov/?q=crocodile&pg=3&id=EJ537653"><span id="translatedtitle">Crocodile Talk: Attributions of Incestuously Abused and Nonabused <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Monahan, Kathleen</p> <p>1997-01-01</p> <p>This qualitative study analyzed the retrospective attributions of adult <span class="hlt">sisters</span> (five abused <span class="hlt">sister</span> dyads, and five abused and nonabused <span class="hlt">sister</span> dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=2&id=EJ656516','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=2&id=EJ656516"><span id="translatedtitle">The Lay <span class="hlt">Sister</span> in Educational History and Memory.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Jack, Christine Trimingham</p> <p>2000-01-01</p> <p>Focuses on the construction of lay <span class="hlt">sisters</span> in a religious order and school setting using a poststructuralist orientation. Explains that in the study documents were examined and interviews were conducted with ex-students, choir nuns, and a lay <span class="hlt">sister</span> at a small Catholic girls-preparatory boarding school. Explores the narrative of one lay <span class="hlt">sister</span>.…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_1");'>1</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li class="active"><span>3</span></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_3 --> <div id="page_4" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active"><span>4</span></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="61"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-03-07/pdf/2012-5533.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-03-07/pdf/2012-5533.pdf"><span id="translatedtitle">77 FR 13585 - Three <span class="hlt">Sisters</span> Irrigation District; Notice of Application Accepted for Filing and Soliciting...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-03-07</p> <p>... COMMISSION Three <span class="hlt">Sisters</span> Irrigation District; Notice of Application Accepted for Filing and Soliciting..., 2012. d. Applicant: Three <span class="hlt">Sisters</span> Irrigation District. e. Name of Project: Three <span class="hlt">Sisters</span> Irrigation District Hydroelectric Project. f. Location: The proposed Three <span class="hlt">Sisters</span> Irrigation District...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23954140','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23954140"><span id="translatedtitle">Clinicopathologic significance of immunostaining of α-thalassemia/mental retardation syndrome X-<span class="hlt">linked</span> protein and <span class="hlt">death</span> domain-associated protein in neuroendocrine tumors.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Shi-Fan; Kasajima, Atsuko; Yazdani, Samaneh; Chan, Monica S M; Wang, Lin; He, Yang-Yang; Gao, Hong-Wen; Sasano, Hironobu</p> <p>2013-10-01</p> <p>α-Thalassemia/mental retardation syndrome X-<span class="hlt">linked</span> protein (ATRX) and <span class="hlt">death</span> domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are specific for pancreatic neuroendocrine tumor. In addition, the association of ATRX/DAXX protein loss with tumor cell proliferation has not been examined. We, therefore, immunostained ATRX and DAXX in 10 gastric, 15 duodenal, 20 rectal, 70 pancreatic, and 22 pulmonary neuroendocrine tumors with 15 nonneoplastic pancreases and 27 pancreatic adenocarcinomas to elucidate the site-specific roles of ATRX/DAXX abnormalities. At least 1 loss of ATRX and DAXX immunoreactivity was detected in all neuroendocrine tumor cases but not in any of nonneoplastic pancreatic tissues or pancreatic adenocarcinomas. The loss of DAXX protein was correlated with the Ki-67 index (ATRX, P = .904; DAXX, P = .044). The status of DAXX immunoreactivity correlated positively with World Health Organization histologic grade (P = .026). These results suggest that the status of ATRX or DAXX protein loss in neuroendocrine tumor differed among the organs in which these tumors arose, and these proteins may play site-specific roles in the development of these tumors. PMID:23954140</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2743075','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2743075"><span id="translatedtitle">Catholic Nursing <span class="hlt">Sisters</span> and Brothers and Racial Justice in Mid-20th-Century America</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wall, Barbra Mann</p> <p>2009-01-01</p> <p>This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious <span class="hlt">sisters</span> and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were <span class="hlt">linked</span> to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the <span class="hlt">sisters</span> themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic <span class="hlt">sister</span> and brother nurses in the mid-20th century are chronicled, including those few <span class="hlt">sister</span> nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/254378','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/254378"><span id="translatedtitle">Two <span class="hlt">sisters</span> with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kondoh, T.; Hayashi, K.; Matsumoto, T.</p> <p>1995-10-09</p> <p>We report two <span class="hlt">sisters</span> in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-<span class="hlt">linked</span> immunodeficiency disorder. An elder <span class="hlt">sister</span> had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger <span class="hlt">sister</span> had the same manifestations as the elder <span class="hlt">sister`s</span> for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder <span class="hlt">sister</span> a 115-KD band that should be specific for sialophorin was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each <span class="hlt">sister</span> had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-<span class="hlt">linked</span> WAS. 17 refs., 6 figs., 1 tab.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1006063.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1006063.pdf"><span id="translatedtitle"><span class="hlt">Sister</span> Mary Emil Penet, I.H.M.: Founder of the <span class="hlt">Sister</span> Formation Conference</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Glisky, Joan</p> <p>2006-01-01</p> <p>Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the <span class="hlt">Sister</span> Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5020959','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5020959"><span id="translatedtitle">Bardet-Biedl syndrome in two <span class="hlt">sisters</span>: A rare incidence</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Varma, Chaitanya; Bhat, Ramesh Y.; Bhatt, Sonia</p> <p>2013-01-01</p> <p>Bardet-Biedl syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa, obesity, polydactyly, mental retardation and hypogonadism. We present two <span class="hlt">sisters</span> with this rare genetic condition.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/9023020','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/9023020"><span id="translatedtitle">Crocodile talk: attributions of incestuously abused and nonabused <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Monahan, K</p> <p>1997-01-01</p> <p>This study is a qualitative analysis of the attributions of <span class="hlt">sisters</span> (abused and nonabused <span class="hlt">sister</span> dyads, n = 10 and abused <span class="hlt">sister</span> dyads, n = 10) who grew up in an incestuous family. While the sibling subsystem is reported to be the most important and enduring relational environment in the life of the family, little is known about the cognitions and attributions of siblings, regarding incest. This study examines the attributions of participants regarding the general sibling group, victim selection and nonselection, as well as attributions regarding jealousy, protection, and guilt within the <span class="hlt">sister</span> relationship. PMID:9023020</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2014AGUFM.B21D0073D&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2014AGUFM.B21D0073D&link_type=ABSTRACT"><span id="translatedtitle">Carbon associated nitrate (CAN) in the Ediacaran Johnnie Formation, <span class="hlt">Death</span> Valley, California and <span class="hlt">links</span> to the Shuram negative carbon isotope excursion</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Dilles, Z. Y. G.; Prokopenko, M. G.; Bergmann, K.; Loyd, S. J.; Corsetti, F. A.; Berelson, W.; Gaines, R. R.</p> <p>2014-12-01</p> <p>Nitrogen, a major nutrient of marine primary production whose many redox states are <span class="hlt">linked</span> through biological processes to O2, may afford better understanding of changes in post-Great Oxidation Event (GOE) environmental redox conditions. Using a novel approach to quantify nitrate content in carbonates, we identified a trend of CAN increase in the late-Proterozoic, including several distinct peaks within a carbonate succession of the Sonora province, Mexico, deposited ~630-500 Ma. The goal of the current study was to investigate CAN variability in the context of the global "Shuram" event, a large negative δ13C excursion expressed in Rainstorm member carbonates of the Johnnie Formation in <span class="hlt">Death</span> Valley, CA. The lower Rainstorm Member "Johnnie Oolite", a time-transgressive, regionally extensive, shallow dolomitic oolite, was sampled. CAN concentrations ranged from 7.31 to 127.36 nmol/g, with higher values measured toward the base of the bed. This trend held at each sampled locality, along with a tendency towards decreasing CAN with larger magnitude negative δ13C excursions. Modern analog ooids formed in low-latitude marine environments lack CAN, consistent with their formation in low-nitrate waters of the euphotic zone characteristic of the modern ocean nitrogen cycling. In contrast, maximum values within the Johnnie oolite exceed by a factor of five to seven CAN measured in carbonates deposited below the main nitracline in the modern ocean, implying high nitrate content within shallow depositional environments. Johnnie oolite data, broadly consistent with the Sonora sequence findings, may indicate large perturbations in the Ediacaran nitrogen cycle immediately preceding the negative δ13C excursion. The implication of these findings for possible changes in the Ediacaran nitrogen, oxygen and carbon biogeochemical cycling will be further discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Cold+AND+international+AND+relations&pg=3&id=EJ437613','ERIC'); return false;" href="http://eric.ed.gov/?q=Cold+AND+international+AND+relations&pg=3&id=EJ437613"><span id="translatedtitle">Building International Relations for Children through <span class="hlt">Sister</span> Schools.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Pryor, Carolyn B.</p> <p>1992-01-01</p> <p>Inspired by <span class="hlt">Sister</span> Cities International and the NASSP's school-to-school exchange program, "<span class="hlt">sister</span> school" pairings have proved to be workable educational programs with long-range impact on participants. Some post-cold war efforts include U.S.-USSR High School Academic Partnerships, Project Harmony, and Center for U.S.-USSR Initiatives. Resource…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+girl&pg=6&id=EJ811809','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+girl&pg=6&id=EJ811809"><span id="translatedtitle">Mentoring At-Risk Adolescent Girls: Listening to "Little <span class="hlt">Sisters</span>"</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Maldonado, Nancy L.; Quarles, Alice; Lacey, Candace H.; Thompson, Steve D.</p> <p>2008-01-01</p> <p>In order to develop an understanding of mentoring relationships and the impact these relationships might have on the development of high-risk adolescent girls, this qualitative study explored the relationships between six "Little <span class="hlt">Sisters</span>" and their "Big <span class="hlt">Sister</span>" mentors. The purposefully-selected sample includes women and girls who were actively…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/1088162','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/1088162"><span id="translatedtitle">[Concordant deuteranomaly in monozygotic twin <span class="hlt">sisters</span> (author's transl)].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Franceschetti, A T; Klein, D; Dieterle, P</p> <p>1976-12-01</p> <p>Colorblind twin <span class="hlt">sisters</span> were born from the marriage of a hemizygote with a carrier for colorblindness. The proof of monozygosity is given by the blood-group typing and the dermatoglyphs. The deuteranomaly is of the same degree in each but is more marked in one of the <span class="hlt">sisters</span>. The mother has none of the microsymptoms sometimes found in carriers. PMID:1088162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol4/pdf/CFR-2014-title46-vol4-sec116-210.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol4/pdf/CFR-2014-title46-vol4-sec116-210.pdf"><span id="translatedtitle">46 CFR 116.210 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... 46 Shipping 4 2014-10-01 2014-10-01 false Plans for <span class="hlt">sister</span> vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for <span class="hlt">sister</span> vessels. (a) Plans are not required for a vessel that is a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol4/pdf/CFR-2012-title46-vol4-sec116-210.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol4/pdf/CFR-2012-title46-vol4-sec116-210.pdf"><span id="translatedtitle">46 CFR 116.210 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 46 Shipping 4 2012-10-01 2012-10-01 false Plans for <span class="hlt">sister</span> vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for <span class="hlt">sister</span> vessels. (a) Plans are not required for a vessel that is a...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec177-210.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec177-210.pdf"><span id="translatedtitle">46 CFR 177.210 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for <span class="hlt">sister</span> vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for <span class="hlt">sister</span> vessels. (a) Plans are not...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec177-210.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec177-210.pdf"><span id="translatedtitle">46 CFR 177.210 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for <span class="hlt">sister</span> vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for <span class="hlt">sister</span> vessels. (a) Plans are not...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title46-vol7/pdf/CFR-2011-title46-vol7-sec169-307.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title46-vol7/pdf/CFR-2011-title46-vol7-sec169-307.pdf"><span id="translatedtitle">46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-10-01</p> <p>... 46 Shipping 7 2011-10-01 2011-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol7/pdf/CFR-2014-title46-vol7-sec169-307.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title46-vol7/pdf/CFR-2014-title46-vol7-sec169-307.pdf"><span id="translatedtitle">46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-10-01</p> <p>... 46 Shipping 7 2014-10-01 2014-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec169-307.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec169-307.pdf"><span id="translatedtitle">46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec169-307.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title46-vol7/pdf/CFR-2012-title46-vol7-sec169-307.pdf"><span id="translatedtitle">46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-10-01</p> <p>... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec169-307.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title46-vol7/pdf/CFR-2013-title46-vol7-sec169-307.pdf"><span id="translatedtitle">46 CFR 169.307 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-10-01</p> <p>... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for <span class="hlt">sister</span> vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for <span class="hlt">sister</span> vessels. Plans are not required for any...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_2");'>2</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li class="active"><span>4</span></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_4 --> <div id="page_5" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="81"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec177-210.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title46-vol7/pdf/CFR-2010-title46-vol7-sec177-210.pdf"><span id="translatedtitle">46 CFR 177.210 - Plans for <span class="hlt">sister</span> vessels.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-10-01</p> <p>... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for <span class="hlt">sister</span> vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for <span class="hlt">sister</span> vessels. (a) Plans are not...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8557450','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8557450"><span id="translatedtitle">A comparison of sisterhood information on causes of maternal <span class="hlt">death</span> with the registration causes of maternal <span class="hlt">death</span> in Matlab, Bangladesh.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shahidullah, M</p> <p>1995-10-01</p> <p>This study compared the sisterhood method of determining causes of maternal <span class="hlt">death</span>, an indirect method for providing a community-based estimate of the level of maternal mortality, with the Matlab Demographic Surveillance System's (DSS) causes of maternal <span class="hlt">death</span>. Data were derived from the Matlab DSS, which has been in operation since 1966 as a field site of the International Center for Diarrheal Disease Research, Bangladesh. The maternal <span class="hlt">deaths</span> that occurred during the 15-year period from 1976 to 1990 in the Matlab DSS area were the basis of this study. A sisterhood survey was conducted in Matlab in November and December 1991 to collect information on conditions, events, and symptoms that preceded <span class="hlt">death</span>. The collected information was evaluated to assign a most likely cause of maternal <span class="hlt">death</span>. The sisterhood survey cause of maternal <span class="hlt">death</span> was then compared with the DSS cause of maternal <span class="hlt">death</span>. Of the 510 <span class="hlt">deaths</span> identified as maternal <span class="hlt">deaths</span> by the DSS, 384 siblings, 1 for each deceased woman, was interviewed. 305 of these correctly reported that they had a <span class="hlt">sister</span> who died during pregnancy or childbirth. 16 reported that they did not know whether their <span class="hlt">sister</span> died during pregnancy or after termination of a pregnancy. The remaining 63 respondents misreported their <span class="hlt">sisters</span>' <span class="hlt">deaths</span> as nonmaternal <span class="hlt">deaths</span>. Cause of <span class="hlt">death</span> could not be assigned with reasonable confidence for 34 (11%) of the 305 maternal <span class="hlt">deaths</span> for which information was collected. For the remaining 271 <span class="hlt">deaths</span>, the agreement between the 2 classification systems was generally high for most cause-of-<span class="hlt">death</span> categories considered. The overall rate of agreement between DSS cause and survey cause was 82%. For the direct obstetric <span class="hlt">deaths</span> as a group, the agreement was 86%, while it was around 76% for indirect obstetric <span class="hlt">deaths</span>, and 71% for abortion-related <span class="hlt">deaths</span>. Though the sisterhood method will always be subject to some error, it can provide an indication of an overall distribution of causes of maternal <span class="hlt">deaths</span>. PMID</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25601100','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25601100"><span id="translatedtitle">Partial dosage compensation in Strepsiptera, a <span class="hlt">sister</span> group of beetles.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mahajan, Shivani; Bachtrog, Doris</p> <p>2015-02-01</p> <p>Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila, downregulation of both X's in XX Caenorhabditis, or inactivation of one X in female mammals. In the flour beetle Tribolium, the X appears hyperexpressed in both sexes, which might represent the first of two steps to evolve dosage compensation along the paths mammals may have taken (i.e., upregulation of X in both sexes, followed by inactivation of one X in females). Here we test for dosage compensation in Strepsiptera, a <span class="hlt">sister</span> taxon to beetles. We identify sex-<span class="hlt">linked</span> chromosomes in Xenos vesparum based on genomic analysis of males and females, and show that its sex chromosome consists of two chromosomal arms in Tribolium: The X chromosome that is shared between Tribolium and Strepsiptera, and another chromosome that is autosomal in Tribolium and another distantly related Strepsiptera species, but sex-<span class="hlt">linked</span> in X. vesparum. We use RNA-seq (RNA sequencing) to show that dosage compensation along the X of X. vesparum is partial and heterogeneous. In particular, genes that are X-<span class="hlt">linked</span> in both beetles and Strepsiptera appear fully dosage compensated probably through downregulation in both sexes, whereas genes on the more recently added X segment have evolved only partial dosage compensation. In addition, reanalysis of published RNA-seq data suggests that Tribolium has evolved dosage compensation, without hypertranscribing the X in females. Our results demonstrate that patterns of dosage compensation are highly variable across sex-determination systems and even within species. PMID:25601100</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4350179','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4350179"><span id="translatedtitle">Partial Dosage Compensation in Strepsiptera, a <span class="hlt">Sister</span> Group of Beetles</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mahajan, Shivani; Bachtrog, Doris</p> <p>2015-01-01</p> <p>Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila, downregulation of both X’s in XX Caenorhabditis, or inactivation of one X in female mammals. In the flour beetle Tribolium, the X appears hyperexpressed in both sexes, which might represent the first of two steps to evolve dosage compensation along the paths mammals may have taken (i.e., upregulation of X in both sexes, followed by inactivation of one X in females). Here we test for dosage compensation in Strepsiptera, a <span class="hlt">sister</span> taxon to beetles. We identify sex-<span class="hlt">linked</span> chromosomes in Xenos vesparum based on genomic analysis of males and females, and show that its sex chromosome consists of two chromosomal arms in Tribolium: The X chromosome that is shared between Tribolium and Strepsiptera, and another chromosome that is autosomal in Tribolium and another distantly related Strepsiptera species, but sex-<span class="hlt">linked</span> in X. vesparum. We use RNA-seq (RNA sequencing) to show that dosage compensation along the X of X. vesparum is partial and heterogeneous. In particular, genes that are X-<span class="hlt">linked</span> in both beetles and Strepsiptera appear fully dosage compensated probably through downregulation in both sexes, whereas genes on the more recently added X segment have evolved only partial dosage compensation. In addition, reanalysis of published RNA-seq data suggests that Tribolium has evolved dosage compensation, without hypertranscribing the X in females. Our results demonstrate that patterns of dosage compensation are highly variable across sex-determination systems and even within species. PMID:25601100</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23747271','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23747271"><span id="translatedtitle">Radiation-induced mitotic cell <span class="hlt">death</span> and glioblastoma radioresistance: a new regulating pathway controlled by integrin-<span class="hlt">linked</span> kinase, hypoxia-inducible factor 1 alpha and survivin in U87 cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lanvin, Olivia; Monferran, Sylvie; Delmas, Caroline; Couderc, Bettina; Toulas, Christine; Cohen-Jonathan-Moyal, Elizabeth</p> <p>2013-09-01</p> <p>We have previously shown that integrin-<span class="hlt">linked</span> kinase (ILK) regulates U87 glioblastoma cell radioresistance by modulating the main radiation-induced cell <span class="hlt">death</span> mechanism in solid tumours, the mitotic cell <span class="hlt">death</span>. To decipher the biological pathways involved in these mechanisms, we constructed a U87 glioblastoma cell model expressing an inducible shRNA directed against ILK (U87shILK). We then demonstrated that silencing ILK enhanced radiation-induced centrosome overduplication, leading to radiation-induced mitotic cell <span class="hlt">death</span>. In this model, ionising radiations induce hypoxia-inducible factor 1 alpha (HIF-1α) stabilisation which is inhibited by silencing ILK. Moreover, silencing HIF-1α in U87 cells reduced the surviving fraction after 2 Gy irradiation by increasing cell sensitivity to radiation-induced mitotic cell <span class="hlt">death</span> and centrosome amplification. Because it is known that HIF-1α controls survivin expression, we then looked at the ILK silencing effect on survivin expression. We show that survivin expression is decreased in U87shILK cells. Furthermore, treating U87 cells with the specific survivin suppressor YM155 significantly increased the percentage of giant multinucleated cells, centrosomal overduplication and thus U87 cell radiosensitivity. In consequence, we decipher here a new pathway of glioma radioresistance via the regulation of radiation-induced centrosome duplication and therefore mitotic cell <span class="hlt">death</span> by ILK, HIF-1α and survivin. This work identifies new targets in glioblastoma with the intention of radiosensitising these highly radioresistant tumours. PMID:23747271</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25999055','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25999055"><span id="translatedtitle">Horsetails are the <span class="hlt">sister</span> group to all other monilophytes and Marattiales are <span class="hlt">sister</span> to leptosporangiate ferns.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Knie, Nils; Fischer, Simon; Grewe, Felix; Polsakiewicz, Monika; Knoop, Volker</p> <p>2015-09-01</p> <p>The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the <span class="hlt">sister</span> clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes. Both introns have orthologues in seed plants where nad2i542g2 has evolved into a trans-arrangement. In contrast and despite substantial size extensions to more than 5kb in Psilotum, nad2i542g2 remains cis-arranged in the monilophytes. For phylogenetic analyses, we filled taxonomic gaps in previously investigated mitochondrial (atp1, nad5) and chloroplast (atpA, atpB, matK, rbcL, rps4) loci and created a 9-gene matrix that also included the new mitochondrial nad2 and rpl2 loci. We extended the taxon sampling with two taxa each for all land plant outgroups (liverworts, mosses, hornworts, lycophytes and seed plants) to minimize the risk of phylogenetic artefacts. We ultimately obtained a well-supported molecular phylogeny placing Marattiales as <span class="hlt">sister</span> to leptosporangiate ferns and horsetails as <span class="hlt">sister</span> to all remaining monilophytes. In addition, an indel in an exon of the here introduced rpl2 locus independently supports the placement of horsetails. We conclude that under dense taxon sampling, phylogenetic information from a prudent choice of loci is currently superior to character-rich phylogenomic approaches at low taxon sampling. As here shown the selective choice of loci and taxa enabled us to resolve the long-enigmatic diversifications of the earliest monilophyte lineages. PMID:25999055</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/mi0639.photos.196598p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/mi0639.photos.196598p/"><span id="translatedtitle">38. 8 <span class="hlt">sisters</span> and powerhouse, pulverizer building for powerhouse, coal ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>38. 8 <span class="hlt">sisters</span> and powerhouse, pulverizer building for powerhouse, coal conveyor, blast stoves, "A" furnace, stoves, "B" furnace, stoves, "C" furnace, bottle cars. Looking south - Rouge Steel Company, 3001 Miller Road, Dearborn, MI</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/dc0640.photos.036900p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/dc0640.photos.036900p/"><span id="translatedtitle">8. STREAMSIDE PATH NEAR MIDDLE OF THREE <span class="hlt">SISTERS</span> FALLS, LOOKING ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>8. STREAM-SIDE PATH NEAR MIDDLE OF THREE <span class="hlt">SISTERS</span> FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Recombination&pg=3&id=EJ384605','ERIC'); return false;" href="http://eric.ed.gov/?q=Recombination&pg=3&id=EJ384605"><span id="translatedtitle">How-to-Do-It: Demonstrating <span class="hlt">Sister</span> Chromatid Exchanges.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Dye, Frank J.</p> <p>1988-01-01</p> <p>Outlines procedures for demonstrating and preparing a permanent slide of <span class="hlt">sister</span> chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/or0493.photos.200307p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/or0493.photos.200307p/"><span id="translatedtitle">UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS <span class="hlt">SISTERED</span> ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS <span class="hlt">SISTERED</span> TO OLDER BEAMS, NEW STRINGERS AND COMPONENTS MAKE UP A NEARLY NEW SUPPORT SYSTEM - Short Bridge, Spanning South Santiam River at High Deck Road, Cascadia, Linn County, OR</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4825568','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4825568"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid decatenation: bridging the gaps in our knowledge</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Broderick, Ronan; Niedzwiedz, Wojciech</p> <p>2015-01-01</p> <p>Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated <span class="hlt">sister</span> chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how <span class="hlt">sister</span> chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process. PMID:26266709</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4843159','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4843159"><span id="translatedtitle">Cholangicarcinoma Presenting as a <span class="hlt">Sister</span> Mary Joseph Nodule</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rangegowda, Devaraja; Vyas, Tanmay; Grover, Shrruti; Joshi, YK; Sharma, Chhagan; Sahney, Amrish</p> <p>2016-01-01</p> <p><span class="hlt">Sister</span> Mary Joseph nodules represent metastatic cancer of the umbilicus. More than half of these cases are attributable to gastrointestinal malignancies including gastric, colonic, and pancreatic cancer. In addition, gynecologic (ovarian, uterine cancer), unknown primary tumors, and, rarely, bladder or respiratory malignancies may cause umbilical metastasis. We report the case of a <span class="hlt">Sister</span> Mary Joseph nodule originating from a hilar cholangiocarcinoma. Umbilical nodules should prompt clinical evaluation, as these tumors are usually associated with poor prognosis. PMID:27144207</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=sudden+AND+death&pg=6&id=EJ322555','ERIC'); return false;" href="http://eric.ed.gov/?q=sudden+AND+death&pg=6&id=EJ322555"><span id="translatedtitle">Cot <span class="hlt">Deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tyrrell, Shelagh</p> <p>1985-01-01</p> <p>Addresses the tragedy of crib <span class="hlt">deaths</span>, giving particular attention to causes, prevention, and medical research on Sudden Infant <span class="hlt">Death</span> Syndrome (SIDS). Gives anecdotal accounts of coping strategies used by parents and families of SIDS infants. (DT)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4890842','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4890842"><span id="translatedtitle">The Excess Winter <span class="hlt">Deaths</span> Measure</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Gasparrini, Antonio</p> <p>2016-01-01</p> <p>Background: Excess winter <span class="hlt">deaths</span>, the ratio between average daily <span class="hlt">deaths</span> in December–March versus other months, is a measure commonly used by public health practitioners and analysts to assess health burdens associated with wintertime weather. We seek to demonstrate that this measure is fundamentally biased and can lead to misleading conclusions about health impacts associated with current and future winter climate. Methods: Time series regression analysis of 779,372 <span class="hlt">deaths</span> from natural causes in London over 15 years (1 August 1997–31 July 2012),collapsed by day of <span class="hlt">death</span> and <span class="hlt">linked</span> to daily temperature values. The outcome measures were the excess winter <span class="hlt">deaths</span> index, and daily and annual <span class="hlt">deaths</span> attributable specifically to cold. Results: Most of the excess winter <span class="hlt">deaths</span> are driven by cold: The excess winter <span class="hlt">deaths</span> index decreased from 1.19 to 1.07 after excluding <span class="hlt">deaths</span> attributable to low temperatures. Over 40% of cold-attributable <span class="hlt">deaths</span> occurred outside of the December–March period, leading to bias in the excess winter <span class="hlt">deaths</span> measure. Although there was no relationship between winter severity and annual excess winter <span class="hlt">deaths</span>, there was a clear correlation with annual cold-attributable <span class="hlt">deaths</span>. Conclusions: Excess winter <span class="hlt">deaths</span> is not an appropriate indicator of cold-related health impacts, and its use should be discontinued. We advocate alternative measures. The findings we present bring into doubt previous claims that cold-related <span class="hlt">deaths</span> in the UK will not reduce in future as a result of climate change. PMID:26986872</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Children+AND+death+AND+mothers&pg=6&id=EJ329850','ERIC'); return false;" href="http://eric.ed.gov/?q=Children+AND+death+AND+mothers&pg=6&id=EJ329850"><span id="translatedtitle">Understanding <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Heath, Charles P.</p> <p>1986-01-01</p> <p>Bibliotherapy can help children prepare for and understand the <span class="hlt">death</span> of a loved one. An annotated bibliography lists references with age level information on attitudes toward <span class="hlt">death</span> and <span class="hlt">deaths</span> of a father, friend, grandparent, mother, pet, and sibling. (Author/CL)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4889787','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4889787"><span id="translatedtitle">GNE Myopathy in Turkish <span class="hlt">Sisters</span> with a Novel Homozygous Mutation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Diniz, Gulden; Secil, Yaprak; Ceylaner, Serdar; Tokucoglu, Figen; Türe, Sabiha; Celebisoy, Mehmet; İncesu, Tülay Kurt; Akhan, Galip</p> <p>2016-01-01</p> <p>Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results. In this study, we present two Turkish <span class="hlt">sisters</span> with progressive myopathy and describe a novel mutation in the GNE gene. Both <span class="hlt">sisters</span> had slightly higher levels of creatine kinase (CK) and muscle weakness. The older <span class="hlt">sister</span> presented at 38 years of age with an inability to climb steps, weakness, and a steppage gait. Her younger <span class="hlt">sister</span> was 36 years old and had similar symptoms. The first symptoms of the disorder were seen when the <span class="hlt">sisters</span> were 30 and 34 years old, respectively. The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. Conclusion. Based on our literature survey, we believe that ours is the first confirmed case of primary GNE myopathy with a novel missense mutation in Turkey. These patients illustrate that the muscle biopsy is still an important method for the differential diagnosis of vacuolar myopathies in that the detection of inclusions is required for the definitive diagnosis. PMID:27298745</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27298745','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27298745"><span id="translatedtitle">GNE Myopathy in Turkish <span class="hlt">Sisters</span> with a Novel Homozygous Mutation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Diniz, Gulden; Secil, Yaprak; Ceylaner, Serdar; Tokucoglu, Figen; Türe, Sabiha; Celebisoy, Mehmet; İncesu, Tülay Kurt; Akhan, Galip</p> <p>2016-01-01</p> <p>Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results. In this study, we present two Turkish <span class="hlt">sisters</span> with progressive myopathy and describe a novel mutation in the GNE gene. Both <span class="hlt">sisters</span> had slightly higher levels of creatine kinase (CK) and muscle weakness. The older <span class="hlt">sister</span> presented at 38 years of age with an inability to climb steps, weakness, and a steppage gait. Her younger <span class="hlt">sister</span> was 36 years old and had similar symptoms. The first symptoms of the disorder were seen when the <span class="hlt">sisters</span> were 30 and 34 years old, respectively. The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. Conclusion. Based on our literature survey, we believe that ours is the first confirmed case of primary GNE myopathy with a novel missense mutation in Turkey. These patients illustrate that the muscle biopsy is still an important method for the differential diagnosis of vacuolar myopathies in that the detection of inclusions is required for the definitive diagnosis. PMID:27298745</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED314204.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED314204.pdf"><span id="translatedtitle">Early Childhood Injury <span class="hlt">Deaths</span> in Washington State.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Starzyk, Patricia M.</p> <p></p> <p>This paper discusses data on the <span class="hlt">deaths</span> of children aged 1-4 years in Washington State. A two-fold approach was used in the analysis. First, Washington State <span class="hlt">death</span> certificate data for 1979-85 were used to characterize the <span class="hlt">deaths</span> and identify hazardous situations. Second, <span class="hlt">death</span> certificates were <span class="hlt">linked</span> to birth certificates of children born in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27477908','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27477908"><span id="translatedtitle">A Long Noncoding RNA Regulates <span class="hlt">Sister</span> Chromatid Cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marchese, Francesco P; Grossi, Elena; Marín-Béjar, Oskar; Bharti, Sanjay Kumar; Raimondi, Ivan; González, Jovanna; Martínez-Herrera, Dannys Jorge; Athie, Alejandro; Amadoz, Alicia; Brosh, Robert M; Huarte, Maite</p> <p>2016-08-01</p> <p>Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types. The expression of CONCR is cell cycle regulated, and it is required for cell-cycle progression and DNA replication. Moreover, cells depleted of CONCR show severe defects in <span class="hlt">sister</span> chromatid cohesion, suggesting an essential role for CONCR in cohesion establishment during cell division. CONCR interacts with and regulates the activity of DDX11, a DNA-dependent ATPase and helicase involved in DNA replication and <span class="hlt">sister</span> chromatid cohesion. These findings unveil a direct role for an lncRNA in the establishment of <span class="hlt">sister</span> chromatid cohesion by modulating DDX11 enzymatic activity. PMID:27477908</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3858829','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3858829"><span id="translatedtitle">Mycelium differentiation and development of Streptomyces coelicolor in lab-scale bioreactors: Programmed cell <span class="hlt">death</span>, differentiation, and lysis are closely <span class="hlt">linked</span> to undecylprodigiosin and actinorhodin production</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Rioseras, Beatriz; López-García, María Teresa; Yagüe, Paula; Sánchez, Jesús; Manteca, Ángel</p> <p>2013-01-01</p> <p>Streptomycetes are mycelium-forming bacteria that produce two thirds of clinically relevant secondary metabolites. Secondary metabolite production is activated at specific developmental stages of Streptomyces life cycle. Despite this, Streptomyces differentiation in industrial bioreactors tends to be underestimated and the most important parameters managed are only indirectly related to differentiation: modifications to the culture media, optimization of productive strains by random or directed mutagenesis, analysis of biophysical parameters, etc. In this work the relationship between differentiation and antibiotic production in lab-scale bioreactors was defined. Streptomyces coelicolor was used as a model strain. Morphological differentiation was comparable to that occurring during pre-sporulation stages in solid cultures: an initial compartmentalized mycelium suffers a programmed cell <span class="hlt">death</span>, and remaining viable segments then differentiate to a second multinucleated antibiotic-producing mycelium. Differentiation was demonstrated to be one of the keys to interpreting biophysical fermentation parameters and to rationalizing the optimization of secondary metabolite production in bioreactors. PMID:24240146</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_3");'>3</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li class="active"><span>5</span></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_5 --> <div id="page_6" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="101"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24240146','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24240146"><span id="translatedtitle">Mycelium differentiation and development of Streptomyces coelicolor in lab-scale bioreactors: programmed cell <span class="hlt">death</span>, differentiation, and lysis are closely <span class="hlt">linked</span> to undecylprodigiosin and actinorhodin production.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rioseras, Beatriz; López-García, María Teresa; Yagüe, Paula; Sánchez, Jesús; Manteca, Angel</p> <p>2014-01-01</p> <p>Streptomycetes are mycelium-forming bacteria that produce two thirds of clinically relevant secondary metabolites. Secondary metabolite production is activated at specific developmental stages of Streptomyces life cycle. Despite this, Streptomyces differentiation in industrial bioreactors tends to be underestimated and the most important parameters managed are only indirectly related to differentiation: modifications to the culture media, optimization of productive strains by random or directed mutagenesis, analysis of biophysical parameters, etc. In this work the relationship between differentiation and antibiotic production in lab-scale bioreactors was defined. Streptomyces coelicolor was used as a model strain. Morphological differentiation was comparable to that occurring during pre-sporulation stages in solid cultures: an initial compartmentalized mycelium suffers a programmed cell <span class="hlt">death</span>, and remaining viable segments then differentiate to a second multinucleated antibiotic-producing mycelium. Differentiation was demonstrated to be one of the keys to interpreting biophysical fermentation parameters and to rationalizing the optimization of secondary metabolite production in bioreactors. PMID:24240146</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19218843','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19218843"><span id="translatedtitle">Catholic <span class="hlt">sister</span> nurses in Selma, Alabama, 1940-1972.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wall, Barbra Mann</p> <p>2009-01-01</p> <p>This study analyzes the activities of religious <span class="hlt">sister</span> nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The <span class="hlt">sisters</span>' work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26948225','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26948225"><span id="translatedtitle">Improving patient flow: role of the orthopaedic discharge <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tytler, Beverley</p> <p>2016-03-01</p> <p>Timely and well-planned discharge improves the patient's experience, contributes to patient safety and reduces the length of hospital stays. The role of orthopaedic discharge <span class="hlt">sister</span> was developed at James Cook University Hospital in 2007 to provide safe, timely and efficient discharge for patients from the trauma and theatre centre, and to improve patient experience and flow. This article gives an overview of the role and describes how the <span class="hlt">sister</span> works with colleagues to plan patient discharges from pre-assessment and emergency department admission through their hospital stay until their departure. PMID:26948225</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27120695','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27120695"><span id="translatedtitle">Separase Is Required for Homolog and <span class="hlt">Sister</span> Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of <span class="hlt">Sister</span> Centromeres.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Blattner, Ariane C; Chaurasia, Soumya; McKee, Bruce D; Lehner, Christian F</p> <p>2016-04-01</p> <p>Spatially controlled release of <span class="hlt">sister</span> chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of <span class="hlt">sister</span> centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain <span class="hlt">sister</span> centromere individualization which is essential for subsequent biorientation of <span class="hlt">sister</span> centromeres during meiosis II. To characterize a potential involvement of separase in <span class="hlt">sister</span> centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that <span class="hlt">sister</span> centromere individualization before meiosis II does not require separase. PMID:27120695</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4847790','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4847790"><span id="translatedtitle">Separase Is Required for Homolog and <span class="hlt">Sister</span> Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of <span class="hlt">Sister</span> Centromeres</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Blattner, Ariane C.; McKee, Bruce D.; Lehner, Christian F.</p> <p>2016-01-01</p> <p>Spatially controlled release of <span class="hlt">sister</span> chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of <span class="hlt">sister</span> centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain <span class="hlt">sister</span> centromere individualization which is essential for subsequent biorientation of <span class="hlt">sister</span> centromeres during meiosis II. To characterize a potential involvement of separase in <span class="hlt">sister</span> centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that <span class="hlt">sister</span> centromere individualization before meiosis II does not require separase. PMID:27120695</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+sister&id=EJ484673','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+sister&id=EJ484673"><span id="translatedtitle">A Profile and Perceptions of Fraternity Little <span class="hlt">Sister</span> Auxiliary Groups.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Scott, Peggy S.; Saracino, Marie</p> <p>1994-01-01</p> <p>Examined fraternity little <span class="hlt">sister</span> auxiliary group members' perceptions of fraternity-related roles/experiences, and identified personality types of women who join such groups. Subjects (n=49) completed Auxiliary Group Questionnaire and Myers-Briggs Type Inventory. Results revealed that 83% of subjects could be classified as extraverted personality…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2399726','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2399726"><span id="translatedtitle">Thrombotic thrombocytopenic purpura associated with pregnancy in two <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Alqadah, F.; Zebeib, M. A.; Awidi, A. S.</p> <p>1993-01-01</p> <p>Two <span class="hlt">sisters</span> suffered from thrombotic thrombocytopenic purpura late in their first pregnancies. HLA typing of the patients and their immediate family members demonstrated no obvious relationship. Hereditary aspects, association with pregnancy, prognosis and management of pregnant women with TTP are discussed. PMID:8497440</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2766539','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2766539"><span id="translatedtitle">Precocious <span class="hlt">Sister</span> Chromatid Separation (PSCS) in Cornelia de Lange Syndrome</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kaur, Maninder; DeScipio, Cheryl; McCallum, Jennifer; Yaeger, Dinah; Devoto, Marcella; Jackson, Laird G.; Spinner, Nancy B.; Krantz, Ian D.</p> <p>2009-01-01</p> <p>The Cornelia de Lange syndrome (CdLS) (OMIM# 122470) is a dominantly inherited multisystem developmental disorder. The phenotype consists of characteristic facial features, hirsutism, abnormalities of the upper extremities ranging from subtle changes in the phalanges and metacarpal bones to oligodactyly and phocomelia, gastroesophageal dysfunction, growth retardation, and neurodevelopmental delay. Prevalence is estimated to be as high as 1 in 10,000. Recently, mutations in NIPBL were identified in sporadic and familial CdLS cases. To date, mutations in this gene have been identified in over 45% of individuals with CdLS. NIPBL is the human homolog of the Drosophila Nipped-B gene. Although its function in mammalian systems has not yet been elucidated, sequence homologs of Nipped-B in yeast (Scc2 and Mis4) are required for <span class="hlt">sister</span> chromatid cohesion during mitosis, and a similar role was recently demonstrated for Nipped-B in Drosophila. In order to evaluate NIPBL role in <span class="hlt">sister</span> chromatid cohesion in humans, metaphase spreads on 90 probands (40 NIPBL mutation positive and 50 NIPBL mutation negative) with CdLS were evaluated for evidence of precocious <span class="hlt">sister</span> chromatid separation (PSCS). We screened 50 metaphases from each proband and found evidence of PSCS in 41% (compared to 9% in control samples). These studies indicate that NIPBL may play a role in <span class="hlt">sister</span> chromatid cohesion in humans as has been reported for its homologs in Drosophila and yeast. PMID:16100726</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/dc0640.photos.036899p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/dc0640.photos.036899p/"><span id="translatedtitle">7. STREAMSIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE <span class="hlt">SISTERS</span> ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>7. STREAM-SIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE <span class="hlt">SISTERS</span> FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=relationship&pg=3&id=EJ1069817','ERIC'); return false;" href="http://eric.ed.gov/?q=relationship&pg=3&id=EJ1069817"><span id="translatedtitle">Adult Sibling Relationships with Brothers and <span class="hlt">Sisters</span> with Severe Disabilities</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rossetti, Zach; Hall, Sarah</p> <p>2015-01-01</p> <p>The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or <span class="hlt">sister</span> with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=innovation+AND+management&pg=6&id=EJ667313','ERIC'); return false;" href="http://eric.ed.gov/?q=innovation+AND+management&pg=6&id=EJ667313"><span id="translatedtitle">Clinical Design Sciences: A View from <span class="hlt">Sister</span> Design Efforts.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Zaritsky, Raul; Kelly, Anthony E.; Flowers, Woodie; Rogers, Everett; O'Neill, Patrick</p> <p>2003-01-01</p> <p>Asserts that the social sciences are clinical-like endeavors, and the way that "<span class="hlt">sister</span>" fields discover and validate their results may inform research practice in education. Describes three fields of design that confront similar societal demands for improvement (engineering product design, research on the diffusion of innovations, and management…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Freud&id=EJ827914','ERIC'); return false;" href="http://eric.ed.gov/?q=Freud&id=EJ827914"><span id="translatedtitle">Freud on Brothers and <span class="hlt">Sisters</span>: A Neglected Topic</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Sherwin-White, Susan</p> <p>2007-01-01</p> <p>This paper explores Freud's developing thought on brothers and <span class="hlt">sisters</span>, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4845193','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4845193"><span id="translatedtitle">DNA damage tolerance branches out toward <span class="hlt">sister</span> chromatid cohesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Branzei, Dana</p> <p>2016-01-01</p> <p>ABSTRACT Genome duplication is temporarily coordinated with <span class="hlt">sister</span> chromatid cohesion and DNA damage tolerance. Recently, we found that replication fork-coupled repriming is important for both optimal cohesion and error-free replication by recombination. The mechanism involved has implications for the etiology of replication-based genetic diseases and cancer. PMID:27308553</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=identical+AND+twin+AND+studies&pg=6&id=ED313842','ERIC'); return false;" href="http://eric.ed.gov/?q=identical+AND+twin+AND+studies&pg=6&id=ED313842"><span id="translatedtitle">Language and Cognitive Development of Deaf and Hearing Twin <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Schirmer, Barbara R.</p> <p></p> <p>In this case study, the language and cognitive development of a 4-year 5-month old profoundly deaf girl and her normally hearing identical twin <span class="hlt">sister</span> were investigated by videotaping the twins in their home interacting with each other, the investigator, and family members. Materials used with the children were designed to elicit spontaneous,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26899633','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26899633"><span id="translatedtitle">Practicing <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Avny, Ohad; Alon, Aya</p> <p>2016-07-01</p> <p>This narrative describes the struggle of a primary care physician contending with the challenge of remaining committed to his patient's care despite a sense of burnout in relation to an intense period of patient <span class="hlt">deaths</span>. The story presents two patient <span class="hlt">deaths</span> and the physician's reflections on how he handled both cases. PMID:26899633</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=49851&keyword=inequality&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76725160&CFTOKEN=61978598','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=49851&keyword=inequality&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76725160&CFTOKEN=61978598"><span id="translatedtitle">TISSUE-SPECIFIC <span class="hlt">SISTER</span> CHROMATID EXCHANGE ANALYSES IN MUTAGEN-CARCINOGEN EXPOSED ANIMALS</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>The phenomenon of <span class="hlt">sister</span> chromatid exchange (SCE) has been extensively reviewed. <span class="hlt">Sister</span> chromatid exchanges are intrachromosomal events, wherein segments of DNA are reciprocally swapped between the chromatids. They are most easily studied with 5-bromodeoxyuridine (BrdU) dye metho...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3960080','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3960080"><span id="translatedtitle">Sibling Conversations about Dating and Sexuality: <span class="hlt">Sisters</span> as Confidants, Sources of Support, and Mentors</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Killoren, Sarah E.; Roach, Andrea L.</p> <p>2013-01-01</p> <p>Using an observational methodology to examine sibling communication, <span class="hlt">sisters</span> (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by <span class="hlt">sisters</span> during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: <span class="hlt">sisters</span> as confidants, sources of support, and mentors. Older and younger <span class="hlt">sisters</span> both served as confidants and sources of support for one another, whereas, older <span class="hlt">sisters</span> were more likely to be mentors for their younger <span class="hlt">sisters</span> than vice versa. Findings indicate the potential importance of <span class="hlt">sisters</span> in the formation of adolescent girls’ ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters’ similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older <span class="hlt">sisters</span> in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1949219','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1949219"><span id="translatedtitle"><span class="hlt">Death</span> duties</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Myers, Kathryn A.; Eden, David</p> <p>2007-01-01</p> <p>PROBLEM BEING ADDRESSED Family physicians are often called upon to pronounce and certify the <span class="hlt">deaths</span> of patients. Inadequate knowledge of the Coroners Act (in the province of Ontario) and of the correct process of certifying <span class="hlt">death</span> can make physicians uncomfortable when confronted with these tasks. OBJECTIVE OF PROGRAM To educate family physicians about how to perform the administrative tasks required of them when patients die. PROGRAM DESCRIPTION The program included an educational video, a tutorial outlining the process of <span class="hlt">death</span> certification, and discussion with a regional coroner about key features of the Coroners Act. In small groups, participants worked through cases of patient <span class="hlt">deaths</span> in which they were asked to determine whether a coroner needed to be involved, to determine the manner of <span class="hlt">death</span>, and to complete a mock <span class="hlt">death</span> certificate for each case. CONCLUSION All participants reported a high level of satisfaction with the workshop and thought the main objective of the program had been achieved. Results of a test given 3 months after the workshop showed substantial improvement in participants’ knowledge of the coroner’s role and of the process of <span class="hlt">death</span> certification. PMID:17872782</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/sim3186','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/sim3186"><span id="translatedtitle">Geologic map of Three <span class="hlt">Sisters</span> volcanic cluster, Cascade Range, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.</p> <p>2012-01-01</p> <p>The cluster of glaciated stratovolcanoes called the Three Sisters—South <span class="hlt">Sister</span>, Middle <span class="hlt">Sister</span>, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North <span class="hlt">Sister</span> (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle <span class="hlt">Sister</span> (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South <span class="hlt">Sister</span> is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South <span class="hlt">Sister</span>, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+sister&id=EJ906857','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+sister&id=EJ906857"><span id="translatedtitle">Testing of the "Healthy 'Little' Lives Project": A Training Program for Big <span class="hlt">Sister</span> Mentors</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kaufman, Michelle R.</p> <p>2010-01-01</p> <p>Big Brothers/Big <span class="hlt">Sisters</span> is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big <span class="hlt">Sister</span> mentors could be trained to increase communication with their Little <span class="hlt">Sisters</span> about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_4");'>4</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li class="active"><span>6</span></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_6 --> <div id="page_7" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="121"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3129082','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3129082"><span id="translatedtitle"><span class="hlt">Sister</span> Mary Joseph nodule-A case report with review of literature</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dar, Ishrat Hussain; Kamili, Mqtasid Ahmed; Dar, Showkat Hussain; Kuchaai, Faiz Ahmed</p> <p>2009-01-01</p> <p><span class="hlt">Sister</span> Mary Joseph nodule or <span class="hlt">Sister</span> Mary Joseph Sign refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. A rare case of <span class="hlt">Sister</span> Mary Joseph nodule, manifesting as ascites, cachexia and bleeding per rectum, is presented without any primary tumor despite extensive search for the same. PMID:21772912</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26373274','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26373274"><span id="translatedtitle">Keeping It in the Family: ATRX Loss Promotes Persistent <span class="hlt">Sister</span> Telomere Cohesion in ALT Cancer Cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Roake, Caitlin M; Artandi, Steven E</p> <p>2015-09-14</p> <p>In this issue of Cancer Cell, Ramamoorthy and Smith report that cancer cells that maintain their chromosome ends through alternative lengthening of telomeres (ALT) display persistent <span class="hlt">sister</span> telomere cohesion. This delayed resolution of <span class="hlt">sister</span> telomere cohesion depends upon the loss of ATRX and its histone-sequestering function and is associated with increased recombination between <span class="hlt">sister</span> telomeres. PMID:26373274</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.marchofdimes.org/complications/neonatal-death.aspx','NIH-MEDLINEPLUS'); return false;" href="http://www.marchofdimes.org/complications/neonatal-death.aspx"><span id="translatedtitle">Neonatal <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... story First Candle Centering Corporation The Compassionate Friends Star Legacy Foundation Last reviewed: November, 2015 Neonatal <span class="hlt">death</span> ... story First Candle Centering Corporation The Compassionate Friends Star Legacy Foundation Last reviewed: November, 2015 Complications & Loss ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1794387','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1794387"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Robinson, Nicholas P; Blood, Katherine A; McCallum, Simon A; Edwards, Paul A W; Bell, Stephen D</p> <p>2007-01-01</p> <p>Although the Archaea exhibit an intriguing combination of bacterial- and eukaryotic-like features, it is not known how these prokaryotic cells segregate their chromosomes before the process of cell division. In the course of our analysis of the third replication origin in the archaeon Sulfolobus solfataricus, we identify and characterise <span class="hlt">sister</span> chromatid junctions in this prokaryote. This pairing appears to be mediated by hemicatenane-like structures, and we provide evidence that these junctions persist in both replicating and postreplicative cells. These data, in conjunction with fluorescent in situ hybridisation analyses, suggest that Sulfolobus chromosomes have a significant period of postreplicative <span class="hlt">sister</span> chromatid synapsis, a situation that is more reminiscent of eukaryotic than bacterial chromosome segregation mechanisms. PMID:17255945</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/14631983','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/14631983"><span id="translatedtitle">[The duties of <span class="hlt">Sisters</span> of Mercy in light of documents].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hałat, S M</p> <p>1999-01-01</p> <p>There are numerous documents in the Archives kept by the Convent of the <span class="hlt">Sisters</span> of Mercy that refer to the taking care of the sick and hospitalization. The article depicts the regulations applicable in the hospital of Angers dating back to the 17th century (reprinted from the French work about St. Vincent a Paulo) and the Polish regulations from the period between the World War I and II kept in the Polish archives. PMID:14631983</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3258253','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3258253"><span id="translatedtitle">Broad Phylogenomic Sampling and the <span class="hlt">Sister</span> Lineage of Land Plants</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Timme, Ruth E.; Bachvaroff, Tsvetan R.; Delwiche, Charles F.</p> <p>2012-01-01</p> <p>The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that ‘stoneworts,’ or Charales, are the <span class="hlt">sister</span> lineage, but an alternative hypothesis supports the Zygnematales (often referred to as “pond scum”) as the <span class="hlt">sister</span> lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the <span class="hlt">sister</span> lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae. PMID:22253761</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12287625','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12287625"><span id="translatedtitle">Southall Black <span class="hlt">Sisters</span>. Hannana Siddiqui speaks to Rasna Warah.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Warah, R</p> <p>1994-01-01</p> <p>Southall Black <span class="hlt">Sisters</span>, an organization for Asian and Afro-Caribbean women in Great Britain, was established in 1979 at the height of anti-racist protests to address the otherwise neglected issue of women's oppression. The group has campaigned against discriminatory immigration laws, illegal virginity tests at Heathrow airport, domestic violence, and other issues of particular concern to British Asian women. Women who migrate to England for an arranged marriage must remain with their husband at least 1 year or face deportation and denial of any public assistance, placing them at risk of unreported domestic violence. Southall Black <span class="hlt">Sisters</span> has attempted to raise the public consciousness about domestic violence as a criminal issue and garner support for Asian women who leave abusive husbands. However, no support has been forthcoming from the anti-racist movement, which fears that publicity on domestic violence will create a racist backlash against Asian men. More support has been available for the group's campaign to protect battered women who kill their husbands by removing from the law on provocation the need for an immediate response. Another campaign has involved protests against "bounty hunters" hired by Asian families to return girls who have escaped from arranged marriages in their home country or sexual abuse within their family. Southall Black <span class="hlt">Sisters</span> attributes many of the problems faced by its clients to a rise in religious fundamentalism and Muslim attempts to reverse the gains of the feminist movement. PMID:12287625</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4465693','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4465693"><span id="translatedtitle">Malignant Triton Tumors in <span class="hlt">Sisters</span> with Clinical Neurofibromatosis Type 1</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Alina, Basnet; Sebastian, Jofre A.; Gerardo, Capo</p> <p>2015-01-01</p> <p>Malignant triton tumors (MTTs) are rare and aggressive sarcomas categorized as a subgroup of malignant peripheral nerve sheath tumors (MPNSTs). MTTs arise from Schwann cells of peripheral nerves or existing neurofibromas and have elements of rhabdomyoblastic differentiation. We report the occurrence of MTTs in two <span class="hlt">sisters</span>. The first patient is a 36-year-old female who presented with left sided chest wall swelling. She also had clinical features consistent with neurofibromatosis type 1 (NF-1). Debulking of the mass showed high-grade malignant peripheral nerve sheath tumor with skeletal muscle differentiation (MTT). The patient was treated with ifosfamide and adriamycin along with radiation. Four years after treatment, she still has no evidence of disease recurrence. Her <span class="hlt">sister</span> subsequently presented to us at the age of 42 with left sided lateral chest wall pain. Imaging showed a multicompartmental retroperitoneal cystic mass with left psoas involvement. The tumor was resected and, similarly to her <span class="hlt">sister</span>, it showed high-grade malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (MTT). The patient was started on chemotherapy and radiation as described above. PMID:26114002</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22253761','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22253761"><span id="translatedtitle">Broad phylogenomic sampling and the <span class="hlt">sister</span> lineage of land plants.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F</p> <p>2012-01-01</p> <p>The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the <span class="hlt">sister</span> lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the <span class="hlt">sister</span> lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the <span class="hlt">sister</span> lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae. PMID:22253761</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20966869','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20966869"><span id="translatedtitle">The <span class="hlt">death</span> of Florence Nightingale: BJN 100 years ago.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Castledine, Sir George</p> <p></p> <p>This August marks the centenary of the <span class="hlt">death</span> of Florence Nightingale, who died at 2 o'clock on Saturday 13 August 1910 at her home, 10 South Street, Park Lane, London. The following are some snippets which appeared in the BJN of the 20 and 27 August 1910. It was not until the announcement of her <span class="hlt">death</span> in the morning papers of Monday 15 August that the country heard about Nightingale's <span class="hlt">death</span>. In her last hours she was attended by Sir Thomas Barlow and two nurses from the Nursing <span class="hlt">Sisters</span>' Institution, Devonshire Square, founded by Mrs Elizabeth Fry in 1840. PMID:20966869</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009AGUFM.V51B1681K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009AGUFM.V51B1681K"><span id="translatedtitle">Strain gradients and melt pathways, Twin <span class="hlt">Sisters</span> complex, Washington State</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kruckenberg, S. C.; Newman, J.; Tikoff, B.; Toy, V. G.</p> <p>2009-12-01</p> <p>The Twin <span class="hlt">Sisters</span> complex in the North Cascades of Washington state is a large (~6 by 16 km), virtually unaltered ultramafic body that provides information about the relationships between the formation of compositional layering, structural fabrics and the formation of inferred melt pathways in naturally deforming peridotites. Compositional layering is largely defined by alternating layers of orthopyroxene-absent dunite (>95% olivine) and orthopyroxene-present (~15% orthopyroxene; ~85% olivine) harzburgite aligned parallel to a roughly N-S striking and steeply dipping foliation. Orthopyroxene- and clinopyroxene-bearing dikes occur throughout the Twin <span class="hlt">Sisters</span> and crosscut the host dunite and harzburgite layering. Orthopyroxene dikes range in thickness from 1 cm to >1 m and are variably oriented and may be folded. Clinopyroxene-bearing dikes are thinner, more consistently oriented (~N-S), and generally more tabular than the orthopyroxene dikes. In the Twin <span class="hlt">Sisters</span>, cm- to m-scale zones of porphyroclastic dunite cross-cut the main dunite-harzburgite compositional layering and display a variety of relationships with pyroxene dikes in the region. These porphyroclastic dunite bands locally contain single olivine grains >10 cm and likely represent former pathways of melt migration. Transect mapping along an E-W traverse across the Twin <span class="hlt">Sisters</span> massif reveals that these inferred melt channels form at various angles relative to the main dunite-harzburgite layering. In the west, porphyroclastic olivine layers form at low angle to the main foliation and compositional layering. These zone form at systematically higher angles across the structural section of the Twin <span class="hlt">Sisters</span> massif to the east and commonly form conjugate cross-cutting sets at high-angle to the main N-S dunite-harzburgite layering. This change in band angle correlates broadly with changes in the intensity of folding of orthopyroxene-bearing dikes, with more intensely deformed dikes in the west to more planar dikes</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('//www.loc.gov/pictures/collection/hh/item/tn0124.photos.154039p/','SCIGOV-HHH'); return false;" href="//www.loc.gov/pictures/collection/hh/item/tn0124.photos.154039p/"><span id="translatedtitle">10. Photocopy of photograph showing the three Walker <span class="hlt">sisters</span> ginning ...</span></a></p> <p><a target="_blank" href="http://www.loc.gov/pictures/collection/hh/">Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey</a></p> <p></p> <p></p> <p>10. Photocopy of photograph showing the three Walker <span class="hlt">sisters</span> ginning cotton. Misses Hettie, Martha and Louisa are from left to right. The original photograph was taken on May 21, 1936 by Edouard E. Exline and is one of five photographs in the album, 'A Sketch of Mountain Life: Great Smoky Mountains National Park', compiled by Edouard E. Exline and C.S. Grossman. The album is on file at the Great Smoky Mountains National Park; the photograph number is III-A-HSE-9642. - Walker Family Farm (General views), Gatlinburg, Sevier County, TN</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2758051','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2758051"><span id="translatedtitle">Catholic <span class="hlt">Sister</span> Nurses in Selma, Alabama, 1940–1972</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wall, Barbra Mann</p> <p>2009-01-01</p> <p>This study analyzes the activities of religious <span class="hlt">sister</span> nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4746374','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4746374"><span id="translatedtitle">Agenesis of the Gallbladder in Monozygotic Twin <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi</p> <p>2016-01-01</p> <p>Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed “gallbladder agenesis.” Moreover, her older identical twin <span class="hlt">sister</span> had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26925274','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26925274"><span id="translatedtitle">Agenesis of the Gallbladder in Monozygotic Twin <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi</p> <p>2016-01-01</p> <p>Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed "gallbladder agenesis." Moreover, her older identical twin <span class="hlt">sister</span> had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25872779','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25872779"><span id="translatedtitle">Faith healers, myths and <span class="hlt">deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wasti, Harihar; Kanchan, Tanuj; Acharya, Jenash</p> <p>2015-09-01</p> <p>Science and myth have been closely <span class="hlt">linked</span> and argued upon by philosophers, educationalists, scientists, enthusiasts and the general public. Faith healing, when added as an adjuvant or alternative aid to medical science, will not necessarily be confined to mere arguments and debates but may also give rise to series of complications, medical emergencies and even result in <span class="hlt">death</span>. We present an unusual case where reliance on faith healing led to the <span class="hlt">death</span> of a young man. PMID:25872779</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6662359','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6662359"><span id="translatedtitle">Eating attitudes and behaviors of anorexia nervosa patients and their <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maloney, M J; Shepard-Spiro, P</p> <p>1983-12-01</p> <p>Although the <span class="hlt">sisters</span> of anorexia nervosa patients may have an increased risk for this disorder, there are no controlled studies of the eating patterns and attitudes of the normal <span class="hlt">sisters</span> of anorexic patients. Twenty-one <span class="hlt">sister</span> pairs (anorexics and their normal <span class="hlt">sisters</span>) were interviewed and given the Eating Attitude Test (EAT) to compare their eating attitudes and behaviors. The mean scores on the EAT and its three subscales (measuring "Dieting," "Bulimia and Food Preoccupation," and "Oral Control") were significantly correlated with criterion group membership (p less than 0.0001). The normal <span class="hlt">sisters</span> as a group did not demonstrate anorexic eating attitudes. However, two normal <span class="hlt">sisters</span> did score in the anorexic range and are being followed prospectively. The EAT questionnaire could be used to screen vulnerable siblings of patients with anorexia nervosa for early signs of this disorder. PMID:6662359</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24182378','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24182378"><span id="translatedtitle">Brain <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wijdicks, Eelco F M</p> <p>2013-01-01</p> <p>The diagnosis of brain <span class="hlt">death</span> should be based on a simple premise. If every possible confounder has been excluded and all possible treatments have been tried or considered, irreversible loss of brain function is clinically recognized as the absence of brainstem reflexes, verified apnea, loss of vascular tone, invariant heart rate, and, eventually, cardiac standstill. This condition cannot be reversed - not even partly - by medical or surgical intervention, and thus is final. Many countries in the world have introduced laws that acknowledge that a patient can be declared brain-dead by neurologic standards. The U.S. law differs substantially from all other brain <span class="hlt">death</span> legislation in the world because the U.S. law does not spell out details of the neurologic examination. Evidence-based practice guidelines serve as a standard. In this chapter, I discuss the history of development of the criteria, the current clinical examination, and some of the ethical and legal issues that have emerged. Generally, the concept of brain <span class="hlt">death</span> has been accepted by all major religions. But patients' families may have different ideas and are mostly influenced by cultural attitudes, traditional customs, and personal beliefs. Suggestions are offered to support these families. PMID:24182378</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22930868','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22930868"><span id="translatedtitle">[The <span class="hlt">death</span> of Ignatius Loyola].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Huguier, Michel; Lacaine, Francois</p> <p>2011-12-01</p> <p>A recent examination of a bilioportal fistula led us to suspect a <span class="hlt">link</span> between this case and the <span class="hlt">death</span> of Ignatius of Loyola. Realdo Colombo, professor of anatomy, eviscerated Ignatius prior to his embalming In his book De re anatomica, published in 1559, he wrote that he extracted stones from the portal vein of the venerable Ignatius. Before his <span class="hlt">death</span>, Ignatius suffered from epigastric pain and fever (Monumenta historica societatis Jesu). Colombo latin text is difficult to interpret and the data are meager. Other possible causes of Ignatius' <span class="hlt">death</span> include gastroduodenal ulcer, tuberculosis and hyperparathyroidism, but despite of rarity bilioportal fistula is the best guess. PMID:22930868</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/1577959','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/1577959"><span id="translatedtitle">Pregnancy risk among the younger <span class="hlt">sisters</span> of pregnant and childbearing adolescents.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>East, P L; Felice, M E</p> <p>1992-04-01</p> <p>There is increasing evidence that younger <span class="hlt">sisters</span> of childbearing teenagers are at increased risk for adolescent childbearing. We critically review this research and discuss three plausible theoretical explanations (social modeling, shared parenting influences, and shared societal risk) why the younger <span class="hlt">sisters</span> of childbearing adolescents would themselves be at risk for teenage pregnancy. Considerations for preventive interventions aimed at the younger <span class="hlt">sisters</span> of pregnant teenagers and directions for future research are discussed. PMID:1577959</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_5");'>5</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li class="active"><span>7</span></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_7 --> <div id="page_8" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="141"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3230346','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3230346"><span id="translatedtitle"><span class="hlt">Sister-sister</span> in vitro fertilization surrogate pregnancy with donor sperm: the case for surrogate gestational pregnancy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Leeton, J; King, C; Harman, J</p> <p>1988-10-01</p> <p>A case of surrogate pregnancy is described in the <span class="hlt">sister</span> of a 40-year-old hysterectomized woman where two oocytes of the latter were fertilized in vitro with known donor sperm and transferred into the surrogate. A normal singleton pregnancy developed which was complicated after 24 weeks of gestation with recurrent antepartum hemorrhages due to grade 3 placenta praevia. A healthy female baby was delivered by elective cesarean section at 36 weeks of gestation. The legal, social, psychological, and ethical issues of surrogacy remain unsettled and are discussed in this case report. PMID:3230346</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3575537','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3575537"><span id="translatedtitle">Condensin II initiates <span class="hlt">sister</span> chromatid resolution during S phase</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ono, Takao; Yamashita, Daisuke</p> <p>2013-01-01</p> <p>Condensins I and II are multisubunit complexes that play essential yet distinct functions in chromosome condensation and segregation in mitosis. Unlike condensin I, condensin II localizes to the nucleus during interphase, but it remains poorly understood what functions condensin II might have before mitotic entry. Here, we report that condensin II changes its chromatin-binding property during S phase. Remarkably, advanced premature chromosome condensation (PCC) assays enabled us to visualize condensin II forming “<span class="hlt">sister</span> axes” in replicated regions of chromosomes in S phase cells. Depletion of condensin II compromised PCC-driven <span class="hlt">sister</span> chromatid resolution during S phase. Moreover, fluorescence in situ hybridization assays revealed that condensin II, but not condensin I, promotes disjoining duplicated chromosomal loci during S phase. Application of mild replicative stress partially impaired this process and further exacerbated phenotypes arising from condensin II depletion. Our results suggest that condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis. PMID:23401001</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4991795','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4991795"><span id="translatedtitle">Investigating the Interplay between <span class="hlt">Sister</span> Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Senaratne, T. Niroshini; Joyce, Eric F.; Wu, C.-ting</p> <p>2016-01-01</p> <p>Following DNA replication, <span class="hlt">sister</span> chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division. This important function involves an evolutionarily conserved protein complex known as cohesin; any loss of cohesin causes premature <span class="hlt">sister</span> chromatid separation in mitosis. Here, we examined the role of cohesin in <span class="hlt">sister</span> chromatid cohesion prior to mitosis, using fluorescence in situ hybridization (FISH) to assay the alignment of <span class="hlt">sister</span> chromatids in interphase Drosophila cells. Surprisingly, we found that <span class="hlt">sister</span> chromatid cohesion can be maintained in G2 with little to no cohesin. This capacity to maintain cohesion is widespread in Drosophila, unlike in other systems where a reduced dependence on cohesin for <span class="hlt">sister</span> chromatid segregation has been observed only at specific chromosomal regions, such as the rDNA locus in budding yeast. Additionally, we show that condensin II antagonizes the alignment of <span class="hlt">sister</span> chromatids in interphase, supporting a model wherein cohesin and condensin II oppose each other’s functions in the alignment of <span class="hlt">sister</span> chromatids. Finally, because the maternal and paternal homologs are paired in the somatic cells of Drosophila, and because condensin II has been shown to antagonize this pairing, we consider the possibility that condensin II-regulated mechanisms for aligning homologous chromosomes may also contribute to <span class="hlt">sister</span> chromatid cohesion. PMID:27541002</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27541002','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27541002"><span id="translatedtitle">Investigating the Interplay between <span class="hlt">Sister</span> Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Senaratne, T Niroshini; Joyce, Eric F; Nguyen, Son C; Wu, C-Ting</p> <p>2016-08-01</p> <p>Following DNA replication, <span class="hlt">sister</span> chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division. This important function involves an evolutionarily conserved protein complex known as cohesin; any loss of cohesin causes premature <span class="hlt">sister</span> chromatid separation in mitosis. Here, we examined the role of cohesin in <span class="hlt">sister</span> chromatid cohesion prior to mitosis, using fluorescence in situ hybridization (FISH) to assay the alignment of <span class="hlt">sister</span> chromatids in interphase Drosophila cells. Surprisingly, we found that <span class="hlt">sister</span> chromatid cohesion can be maintained in G2 with little to no cohesin. This capacity to maintain cohesion is widespread in Drosophila, unlike in other systems where a reduced dependence on cohesin for <span class="hlt">sister</span> chromatid segregation has been observed only at specific chromosomal regions, such as the rDNA locus in budding yeast. Additionally, we show that condensin II antagonizes the alignment of <span class="hlt">sister</span> chromatids in interphase, supporting a model wherein cohesin and condensin II oppose each other's functions in the alignment of <span class="hlt">sister</span> chromatids. Finally, because the maternal and paternal homologs are paired in the somatic cells of Drosophila, and because condensin II has been shown to antagonize this pairing, we consider the possibility that condensin II-regulated mechanisms for aligning homologous chromosomes may also contribute to <span class="hlt">sister</span> chromatid cohesion. PMID:27541002</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26100636','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26100636"><span id="translatedtitle">Inhibition of N-Methyl-D-aspartate-induced Retinal Neuronal <span class="hlt">Death</span> by Polyarginine Peptides Is <span class="hlt">Linked</span> to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Marshall, John; Wong, Kwoon Y; Rupasinghe, Chamila N; Tiwari, Rakesh; Zhao, Xiwu; Berberoglu, Eren D; Sinkler, Christopher; Liu, Jenney; Lee, Icksoo; Parang, Keykavous; Spaller, Mark R; Hüttemann, Maik; Goebel, Dennis J</p> <p>2015-09-01</p> <p>It is widely accepted that overactivation of NMDA receptors, resulting in calcium overload and consequent mitochondrial dysfunction in retinal ganglion neurons, plays a significant role in promoting neurodegenerative disorders such as glaucoma. Calcium has been shown to initiate a transient hyperpolarization of the mitochondrial membrane potential triggering a burst of reactive oxygen species leading to apoptosis. Strategies that enhance cell survival signaling pathways aimed at preventing this adverse hyperpolarization of the mitochondrial membrane potential may provide a novel therapeutic intervention in retinal disease. In the retina, brain-derived neurotrophic factor has been shown to be neuroprotective, and our group previously reported a PSD-95/PDZ-binding cyclic peptide (CN2097) that augments brain-derived neurotrophic factor-induced pro-survival signaling. Here, we examined the neuroprotective properties of CN2097 using an established retinal in vivo NMDA toxicity model. CN2097 completely attenuated NMDA-induced caspase 3-dependent and -independent cell <span class="hlt">death</span> and PARP-1 activation pathways, blocked necrosis, and fully prevented the loss of long term ganglion cell viability. Although neuroprotection was partially dependent upon CN2097 binding to the PDZ domain of PSD-95, our results show that the polyarginine-rich transport moiety C-R(7), <span class="hlt">linked</span> to the PDZ-PSD-95-binding cyclic peptide, was sufficient to mediate short and long term protection via a mitochondrial targeting mechanism. C-R(7) localized to mitochondria and was found to reduce mitochondrial respiration, mitochondrial membrane hyperpolarization, and the generation of reactive oxygen species, promoting survival of retinal neurons. PMID:26100636</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1461886','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1461886"><span id="translatedtitle">Sex determination in the androdioecious plant Datisca glomerata and its dioecious <span class="hlt">sister</span> species D. cannabina.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wolf, D E; Satkoski, J A; White, K; Rieseberg, L H</p> <p>2001-01-01</p> <p>Datisca glomerata is an androdioecious plant species containing male and hermaphroditic individuals. Molecular markers and crossing data suggest that, in both D. glomerata and its dioecious <span class="hlt">sister</span> species D. cannabina, sex is determined by a single nuclear locus, at which maleness is dominant. Supporting this conclusion, an amplified fragment length polymorphism (AFLP) is heterozygous in males and homozygous recessive in hermaphrodites in three populations of the androdioecious species. Additionally, hermaphrodite x male crosses produced 1:1 sex ratios, while hermaphrodite x hermaphrodite crosses produced almost entirely hermaphroditic offspring. No perfectly sex-<span class="hlt">linked</span> marker was found in the dioecious species, but all markers associated with sex mapped to a single linkage group and were heterozygous in the male parent. There was no sex-ratio heterogeneity among crosses within D. cannabina collections, but males from one collection produced highly biased sex ratios (94% females), suggesting that there may be sex-<span class="hlt">linked</span> meiotic drive or a cytoplasmic sex-ratio factor. Interspecific crosses produced only male and female offspring, but no hermaphrodites, suggesting that hermaphroditism is recessive to femaleness. This comparative approach suggests that the hermaphrodite form arose in a dioecious population from a recessive mutation that allowed females to produce pollen. PMID:11729166</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26898580','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26898580"><span id="translatedtitle">Pediatric familial neuromyelitis optica in two <span class="hlt">sisters</span> with long term follow-up.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chuquilin, Miguel; Mullaguri, Naresh; Weinshenker, Brian</p> <p>2016-07-01</p> <p>Neuromyelitis optica causes bilateral optic neuritis and longitudinal extensive transverse myelitis. Although usually sporadic, 3% of cases of neuromyelitis optica are familial. The interval over which attacks continue and the long term prognosis for pediatric-onset neuromyelitis optica are not well defined. We describe two patients with pediatric familial neuromyelitis optica with the longest clinical follow-up of a pediatric case reported in the literature to our knowledge. One woman developed blindness with bilateral eye involvement within a few weeks at age 3. This was followed by transverse myelitis with paraparesis at age 19 leading to diagnosis of neuromyelitis optica. Her serum anti-aquaporin 4 antibody was later found to be positive. She continued with sporadic myelitis-related relapses but remained ambulant until age 40 when she had a more severe relapse. There was evidence of longitudinal extensive T2 hyperintensity in the thoracic spinal cord. Her <span class="hlt">sister</span> also developed blindness at age 3.5 followed by myelitis 1year later with multiple relapses of gait impairment until her <span class="hlt">death</span> from pneumonia at age 21. These patients represent the rare occurrence of neuromyelitis optica in children within the same family and show that this disease can have prolonged periods of remission but a continued tendency to relapse, supporting the need for lifelong immunosuppression. PMID:26898580</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3169009','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3169009"><span id="translatedtitle">Increased <span class="hlt">sister</span> chromatid exchange associated with smoking and coffee consumption.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reidy, J A; Annest, J L; Chen, A T; Welty, T K</p> <p>1988-01-01</p> <p><span class="hlt">Sister</span> chromatid exchange (SCE) is a very sensitive cytogenetic assay for detecting exposure to chemical mutagens and carcinogens. One application of SCE is the monitoring of populations believed to be exposed to such agents. We have, however, relatively little knowledge about common lifestyle factors that may influence SCE and therefore complicate any study designed to examine the effects of exposure to genotoxins. In this study, we assessed the effect of cigarette smoking and coffee consumption on SCE. Smoking was associated with an increase of approximately 2 SCEs per cell and a decrease in cell proliferation. A positive linear relationship between SCE and coffee consumption was also observed. This effect was similar for smokers and nonsmokers. Additionally, the folic acid content of cell culture medium seemed to affect neither SCE nor cell proliferation. PMID:3169009</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6395271','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6395271"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchanges in peripheral lymphocytes after preoperative mammography</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Husum, B.; Wulf, H.C.; Niebuhr, E.</p> <p>1981-09-01</p> <p>Examination of <span class="hlt">sister</span> chromatid exchanges (SCE) in peripheral lymphocytes may be useful for evaluating in vivo exposure to chemical mutagens. In vitro exposure of human lymphocytes to low levels of ionizing radiation has failed to produce increased SCE rates. Scarcity of information about the SCE test system and in vivo exposure to radiation prompted the present study of SCE rates in peripheral lymphocytes in women investigated with mammography prior to operation because of a tumor of the breast. In 64 of a total of 131 women a mammography was performed before the operation. The two groups of patients were identical with respect to age, smoking habits, and incidence of malignancy of the mammary tumors. SCE rates were examined in 30 metaphases from each patient following cultivation of peripheral blood lymphocytes using the BrdU/Giemsa technique.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21452027','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21452027"><span id="translatedtitle">Bold vision: Catholic <span class="hlt">sisters</span> and the creation of American hospitals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Levin, Peter J</p> <p>2011-06-01</p> <p>American hospitals were started by religious, ethnic and community groups to serve local health care needs. Immigration into the eastern cities and the constant movement west of the frontier required the creation of educational and service facilities to serve these populations and localities. In the nineteenth century, Catholic <span class="hlt">sisters</span> went all across the country establishing schools and hospitals. They were motivated to care for the sick, establish charitable institutions and spread their religious beliefs. Their impact on the development of the American health system was enormous. They also supported the importance of nursing for the provision of scientifically based medical care and created schools of nursing. Their historical record as founders, builders, financiers and managers of hospitals is unmatched by any other group between 1850 and 1950. And, this was accomplished at a time when women played no similar leadership and institutional ownership role elsewhere in society. PMID:21452027</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/978252','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/978252"><span id="translatedtitle">Telomere <span class="hlt">sister</span> chromatid exchange in telomerase deficient murine cells</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wang, Yisong; Giannone, Richard J; Liu, Yie</p> <p>2005-01-01</p> <p>We have recently demonstrated that several types of genomic rearrangements (i.e., telomere <span class="hlt">sister</span> chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape 'end crisis'. However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27084937','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27084937"><span id="translatedtitle">Transcription facilitates <span class="hlt">sister</span> chromatid cohesion on chromosomal arms.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bhardwaj, Shweta; Schlackow, Margarita; Rabajdova, Miroslava; Gullerova, Monika</p> <p>2016-08-19</p> <p>Cohesin is a multi-subunit protein complex essential for <span class="hlt">sister</span> chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic. Here, we show two populations of functionally distinct cohesin on chromosomal arms using a combination of genomics and single-locus specific DNA-FISH analysis. Chromatin bound cohesin at the loading sites co-localizes with Pds5 and Eso1 resulting in stable cohesion. In contrast, cohesin independent of its loader is unable to maintain cohesion and associates with chromatin in a dynamic manner. Cohesive sites coincide with highly expressed genes and transcription inhibition leads to destabilization of cohesin on chromatin. Furthermore, induction of transcription results in de novo recruitment of cohesive cohesin. Our data suggest that transcription facilitates cohesin loading onto chromosomal arms and is a key determinant of cohesive sites in fission yeast. PMID:27084937</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26109979','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26109979"><span id="translatedtitle">Mercury poisoning in two 13-year-old twin <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi</p> <p>2015-03-01</p> <p>Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two <span class="hlt">sisters</span>, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis. PMID:26109979</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=older+AND+brother&pg=4&id=EJ626967','ERIC'); return false;" href="http://eric.ed.gov/?q=older+AND+brother&pg=4&id=EJ626967"><span id="translatedtitle"><span class="hlt">Sisters</span>, Brothers, and Delinquency: Evaluating Social Influence during Early and Middle Adolescence.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Slomkowski, Cheryl; Rende, Richard; Conger, Katherine J.; Simons, Ronald L.; Conger, Rand D.</p> <p>2001-01-01</p> <p>Examined sibling influence on delinquency in 164 brother and <span class="hlt">sister</span> pairs over 4-year period. Found that sibling similarity for self-reports of delinquent behavior were highly correlated for brothers and <span class="hlt">sisters</span>. Conditional effects of high hostile-coercive relationships and older sibling delinquency predicted younger sibling delinquency in both…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol16/pdf/CFR-2011-title40-vol16-sec79-65.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title40-vol16/pdf/CFR-2011-title40-vol16-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=siblings+AND+%22+friends%22&pg=6&id=EJ625349','ERIC'); return false;" href="http://eric.ed.gov/?q=siblings+AND+%22+friends%22&pg=6&id=EJ625349"><span id="translatedtitle">Adolescents' Sex-Typed Friendship Experiences: Does Having a <span class="hlt">Sister</span> versus a Brother Matter?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Updegraff, Kimberly A.; McHale, Susan M.; Crouter, Ann C.</p> <p>2000-01-01</p> <p>Examined connections between having a <span class="hlt">sister</span> versus a brother and coming from a same-sex versus an opposite-sex sibling dyad, and sex-typing in adolescents' friendships. Findings suggested that <span class="hlt">sisters</span> may learn control tactics from brothers that they apply in friendships. Boys were less likely to model emotional intimacy. Coming from opposite-sex…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=6&id=EJ1021763','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=6&id=EJ1021763"><span id="translatedtitle">Addressing the Apparent Paradox of the Catholic <span class="hlt">Sister</span> Principal: 1940-1965</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>O'Donoghue, Tom; Harford, Judith</p> <p>2013-01-01</p> <p>A body of scholarship on the history of the lives of Catholic teaching <span class="hlt">sisters</span> has thrown up various challenges to educational historians. One challenge can be posed by asking how teaching <span class="hlt">sisters</span> were able to go on to take up leadership positions. This is prompted by the observation that a particular body of literature for the period 1940-1965…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol17/pdf/CFR-2014-title40-vol17-sec79-65.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title40-vol17/pdf/CFR-2014-title40-vol17-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol17/pdf/CFR-2012-title40-vol17-sec79-65.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title40-vol17/pdf/CFR-2012-title40-vol17-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol17/pdf/CFR-2013-title40-vol17-sec79-65.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title40-vol17/pdf/CFR-2013-title40-vol17-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two <span class="hlt">sister</span> chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_6");'>6</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li class="active"><span>8</span></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_8 --> <div id="page_9" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="161"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/news/fullstory_158574.html','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/news/fullstory_158574.html"><span id="translatedtitle">Officials Report First Zika <span class="hlt">Death</span> in Puerto Rico</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... news/fullstory_158574.html Officials Report First Zika <span class="hlt">Death</span> in Puerto Rico The victim was a 70- ... HealthDay News) -- The first known Zika virus-<span class="hlt">linked</span> <span class="hlt">death</span> in Puerto Rico was announced Friday by officials ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/news/fullstory_158574.html','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/news/fullstory_158574.html"><span id="translatedtitle">Officials Report First Zika <span class="hlt">Death</span> in Puerto Rico</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... gov/news/fullstory_158574.html Officials Report First Zika <span class="hlt">Death</span> in Puerto Rico The victim was a ... April 29, 2016 (HealthDay News) -- The first known Zika virus-<span class="hlt">linked</span> <span class="hlt">death</span> in Puerto Rico was announced ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3794122','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3794122"><span id="translatedtitle">Unusual presentation of two Chinese phenylketonuria <span class="hlt">sisters</span> who were misdiagnosed for years</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Liu, Xiaomei; Guo, Hui; Dahal, Mahesh; Shi, Bingyin</p> <p>2013-01-01</p> <p>Significant developmental delay was first noticed when both <span class="hlt">sisters</span> were in their third year of life. However, no biochemical disorders were found through the routine biochemical tests, including liver and kidney function, lipoprotein, urine and blood cell count analysis. Progressively, both <span class="hlt">sisters</span> exhibited odd behaviour, accompanied by personality changes and altered sleep rhythm and then were diagnosed as attention deficit hyperactivity disorder. In the eighth year, the younger <span class="hlt">sister</span> began to take risperidone due to a presumed psychiatric disorder. Four months before attending our hospital, both <span class="hlt">sisters</span> were diagnosed by MRI as having hereditary leukodystrophy. Nerve-nurturing treatment was tried, but without good outcome. They were then referred to our hospital for further consultation. After systematic examinations, it was confirmed that both the <span class="hlt">sisters</span> were suffering from phenylketonuria. The symptoms were alleviated after dietary restriction of phenylalanine and symptomatic treatment. PMID:24068375</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25839724','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25839724"><span id="translatedtitle">Brain <span class="hlt">death</span>: the Asian perspective.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chua, Hoe Chin; Kwek, Tong Kiat; Morihara, Hirofumi; Gao, Daiquan</p> <p>2015-04-01</p> <p>Asia is the largest and most populous continent in the world with people from many diverse ethnic groups, religions and government systems. The authors surveyed 14 countries accounting for the majority of Asia's population and found that, although the concept of brain <span class="hlt">death</span> is widely accepted, there is wide variability in the criteria for certification. Although most Asian countries have adopted the "whole-brain" concept of brain <span class="hlt">death</span>, most countries with past colonial <span class="hlt">links</span> to the United Kingdom follow the UK "brainstem" concept of brain <span class="hlt">death</span>. Despite this difference, most countries require only neurologic testing of irreversible coma and absent brainstem reflexes as criteria for certification of brain <span class="hlt">death</span>. Variability exists in the number of personnel required, qualifications of certifying doctors, need for repeat examination, minimum time interval between examinations, and requirement for and choice of confirmatory tests. PMID:25839724</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=self+AND+help+AND+book+AND+aid&pg=5&id=ED346375','ERIC'); return false;" href="http://eric.ed.gov/?q=self+AND+help+AND+book+AND+aid&pg=5&id=ED346375"><span id="translatedtitle">Encountering <span class="hlt">Death</span>: Structured Activities for <span class="hlt">Death</span> Awareness.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Welch, Ira David; And Others</p> <p></p> <p>This book is intended to be used as a supplement to standard textbooks on <span class="hlt">death</span> and dying for college students. Chapter 1 "Encountering <span class="hlt">Death</span> in the Self" builds the foundation for increased self-awareness for the study of <span class="hlt">death</span> and dying. Chapter 2 "Encountering <span class="hlt">Death</span> in the Family" provides activities which are appropriate for a wide variety of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4817899','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4817899"><span id="translatedtitle">X-inactivation in the clinical phenotype of fragile X premutation carrier <span class="hlt">sisters</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Robertson-Dick, Erin E.; O'Keefe, Joan A.; Hadd, Andrew G.; Zhou, Lili; Berry-Kravis, Elizabeth</p> <p>2016-01-01</p> <p>Objective: The purpose of this study is to describe a case series of 4 <span class="hlt">sisters</span> with discordant clinical phenotypes associated with fragile X–associated tremor/ataxia syndrome (FXTAS) that may be explained by varying CGG repeat sizes and activation ratios (ARs) (the ratio of cells carrying the normal fragile X mental retardation 1 [FMR1] allele on the active X chromosome). Methods: Four <span class="hlt">sisters</span> with premutation size FMR1 gene repeats underwent detailed clinical characterization. CGG repeat length was determined by PCR, and AR was determined using a newly developed commercial methylation PCR assay and was compared with the results from Southern blot with densitometric image analysis. Results: <span class="hlt">Sister</span> 1 had the largest CGG expansion (82) and the lowest AR (12%), with the most severe clinical presentation. <span class="hlt">Sister</span> 2 had a lower CGG expansion (70) and an AR of 10% but had a milder clinical presentation.<span class="hlt">Sister</span> 3 had a similar CGG expansion (79) but a slightly higher AR of 15% and less neurologic involvement. <span class="hlt">Sister</span> 4 had a similar CGG expansion size of 80 but had the largest AR (40%) and was the only <span class="hlt">sister</span> not to be affected by FXTAS or have any neurologic signs on examination. Conclusions: These results suggest that premutation carrier women who have higher ARs may be less likely to show manifestations of FXTAS. If larger studies show similar patterns, AR data could potentially be beneficial to supplement CGG repeat size when counseling premutation carrier women in the clinic. PMID:27066582</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8055167','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8055167"><span id="translatedtitle">The USA's nurse managers and UK's ward <span class="hlt">sisters</span>: critical roles for empowerment.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cameron-Buccheri, R; Ogier, M E</p> <p>1994-07-01</p> <p>The nurse manager/ward <span class="hlt">sister</span> role is becoming endangered as many of these nurses are being asked to take fiscal and personnel responsibility for multiple units/programmes and supervise more non-registered nursing staff. Loss of this important nurse manager/ward <span class="hlt">sister</span> role could severely decrease nursing's voice in the development and implementation of policies that affect nurses and the care they deliver. The authors review 20 years of literature from both the USA and the UK regarding supportive supervision and the role of the nurse manager/ward <span class="hlt">sister</span>. Nurse managers/ward <span class="hlt">sisters</span> were found to be key individuals within the entire health-care organization. Nurse managers/ward <span class="hlt">sisters</span> can empower the nurses they supervise to initiate changes that will improve patient care. Nurse managers/ward <span class="hlt">sisters</span> can also improve the working conditions and thus increase the job satisfaction and retention of those they supervise. Strategies for being more supportive of these overworked and endangered nurse managers/ward <span class="hlt">sisters</span> are suggested. PMID:8055167</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27136266','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27136266"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid resolution is an intrinsic part of chromosome organization in prophase.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nagasaka, Kota; Hossain, M Julius; Roberti, M Julia; Ellenberg, Jan; Hirota, Toru</p> <p>2016-06-01</p> <p>The formation of mitotic chromosomes requires both compaction of chromatin and the resolution of replicated <span class="hlt">sister</span> chromatids. Compaction occurs during mitotic prophase and prometaphase, and in prophase relies on the activity of condensin II complexes. Exactly when and how <span class="hlt">sister</span> chromatid resolution occurs has been largely unknown, as has its molecular requirements. Here, we established a method to visualize <span class="hlt">sister</span> resolution by sequential replication labelling with two distinct nucleotide derivatives. Quantitative three-dimensional imaging then allowed us to measure the resolution of <span class="hlt">sister</span> chromatids throughout mitosis by calculating their non-overlapping volume within the whole chromosome. Unexpectedly, we found that <span class="hlt">sister</span> chromatid resolution starts already at the beginning of prophase, proceeds concomitantly with chromatin compaction and is largely completed by the end of prophase. <span class="hlt">Sister</span> chromatid resolution was abolished by inhibition of topoisomerase IIα and by depleting or preventing mitotic activation of condensin II, whereas blocking cohesin dissociation from chromosomes had little effect. Mitotic <span class="hlt">sister</span> chromatid resolution is thus an intrinsic part of mitotic chromosome formation in prophase that relies largely on DNA decatenation and shares the molecular requirement for condensin II with prophase compaction. PMID:27136266</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3906944','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3906944"><span id="translatedtitle">The geography and ecology of plant speciation: range overlap and niche divergence in <span class="hlt">sister</span> species</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Anacker, Brian L.; Strauss, Sharon Y.</p> <p>2014-01-01</p> <p>A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of <span class="hlt">sister</span> species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 <span class="hlt">sister</span> species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant <span class="hlt">sisters</span> in the CFP were sympatric in 80% of cases and range sizes of <span class="hlt">sisters</span> differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger <span class="hlt">sisters</span>. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of <span class="hlt">sisters</span> was significantly greater than that of sister–non-<span class="hlt">sister</span> congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the <span class="hlt">sister</span> pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, <span class="hlt">sister</span> taxa and potentially other close relatives, may be missing from local communities</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25946564','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25946564"><span id="translatedtitle">The SUMO deconjugating peptidase Smt4 contributes to the mechanism required for transition from <span class="hlt">sister</span> chromatid arm cohesion to <span class="hlt">sister</span> chromatid pericentromere separation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stephens, Andrew D; Snider, Chloe E; Bloom, Kerry</p> <p>2015-01-01</p> <p>The pericentromere chromatin protrudes orthogonally from the <span class="hlt">sister-sister</span> chromosome arm axis. Pericentric protrusions are organized in a series of loops with the centromere at the apex, maximizing its ability to interact with stochastically growing and shortening kinetochore microtubules. Each pericentromere loop is ∼50 kb in size and is organized further into secondary loops that are displaced from the primary spindle axis. Cohesin and condensin are integral to mechanisms of loop formation and generating resistance to outward forces from kinesin motors and anti-parallel spindle microtubules. A major unanswered question is how the boundary between chromosome arms and the pericentromere is established and maintained. We used <span class="hlt">sister</span> chromatid separation and dynamics of LacO arrays distal to the pericentromere to address this issue. Perturbation of chromatin spring components results in 2 distinct phenotypes. In cohesin and condensin mutants <span class="hlt">sister</span> pericentric LacO arrays separate a defined distance independent of spindle length. In the absence of Smt4, a peptidase that removes SUMO modifications from proteins, pericentric LacO arrays separate in proportion to spindle length increase. Deletion of Smt4, unlike depletion of cohesin and condensin, causes stretching of both proximal and distal pericentromere LacO arrays. The data suggest that the sumoylation state of chromatin topology adjusters, including cohesin, condensin, and topoisomerase II in the pericentromere, contribute to chromatin spring properties as well as the <span class="hlt">sister</span> cohesion boundary. PMID:25946564</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1691261','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1691261"><span id="translatedtitle">Wild female baboons bias their social behaviour towards paternal half-<span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Smith, Kerri; Alberts, Susan C; Altmann, Jeanne</p> <p>2003-01-01</p> <p>Adult female cercopithecines have long been known to bias their social behaviour towards close maternal kin. However, much less is understood about the behaviour of paternal kin, especially in wild populations. Here, we show that wild adult female baboons bias their affiliative behaviour towards their adult paternal half-<span class="hlt">sisters</span> in the same manner and to the same extent that they bias their behaviour towards adult maternal half-<span class="hlt">sisters</span>. Females appear to rely heavily on social familiarity as a means of biasing their behaviour towards paternal half-<span class="hlt">sisters</span>, but may use phenotype matching as well. PMID:12641905</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20203608','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20203608"><span id="translatedtitle">Ecologically distinct dinosaurian <span class="hlt">sister</span> group shows early diversification of Ornithodira.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A</p> <p>2010-03-01</p> <p>The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the <span class="hlt">sister</span> taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier. PMID:20203608</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2632674','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2632674"><span id="translatedtitle">Two <span class="hlt">sisters</span> in the same dress: Heliconius cryptic species</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2008-01-01</p> <p>Background <span class="hlt">Sister</span> species divergence and reproductive isolation commonly results from ecological adaptation. In mimetic Heliconius butterflies, shifts in colour pattern contribute to pre- and post-mating reproductive isolation and are commonly correlated with speciation. Closely related mimetic species are therefore not expected, as they should lack several important sources of reproductive isolation. Results Here we present phenotypic, behavioral and genetic evidence for the coexistence of two sympatric 'cryptic' species near Florencia in the eastern Andes of Colombia that share the same orange rayed colour pattern. These represent H. melpomene malleti and a novel taxon in the H. cydno group, here designated as novel race of Heliconius timareta, Heliconius timareta florencia. No-choice mating experiments show that these sympatric forms have strong assortative mating (≈96%) despite great similarity in colour pattern, implying enhanced divergence in pheromonal signals. Conclusion We hypothesize that these species might have resulted from recent convergence in colour pattern, perhaps facilitated by hybrid introgression of wing pattern genes. PMID:19040737</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12270007','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12270007"><span id="translatedtitle">Cerebrotendinous xanthomatosis: molecular characterization of two Scandinavian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rystedt, E; Olin, M; Seyama, Y; Buchmann, M; Berstad, A; Eggertsen, G; Björkhem, I</p> <p>2002-09-01</p> <p>Cerebrotendinous xanthomatosis (CTX) is a hereditary disorder, which is inherited as an autosomally recessive disease, causing production of cholesterol and cholestanol xanthomas and mental retardation. The disease is caused by mutations in the gene for sterol 27-hydroxylase (CYP27A1). The only CTX patients diagnosed in Scandinavia are two Norwegian <span class="hlt">sisters</span> from a consanguineous marriage. Here we have characterized the mutation and its functional consequences for the enzyme. Analysis of genomic DNA from cultured fibroblasts identified a base exchange C > T in position 1441, causing arginine at amino acid position 441 to be replaced by tryptophan. The same mutation was introduced by mutagenesis in the complimentary DNA (cDNA) for CYP27, ligated into the expression vector pcDNA4/HisMax and transfected into HEK293 cells. The mutated enzyme had less than 5% of the enzyme activity compared with the native enzyme. No abnormal catalytic products could be identified in the cell culture medium. Probably the mutation affects the haem binding within the holoenzyme. The mutation has also previously been reported in a Japanese family. This is the second example of a CTX-causing mutation that has been recognized in more than one population. PMID:12270007</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27290759','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27290759"><span id="translatedtitle">'The <span class="hlt">Sister</span>' in the early days of the NHS.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ellis, Harold</p> <p>2016-04-01</p> <p>All the readers of this journal will have read and heard about the ward and operating theatre <span class="hlt">sisters</span> in 'the old days'. What were they really like, and what was it like to work with them in the hospitals of those far-off times? I entered the old Radcliffe Infirmary Oxford in the summer of 1945, just as World War II was drawing to a close, as a 19 year old student to start my clinical training. I then qualified in July 1948, the very month the NHS came into being, and started my surgical career as house surgeon. The Radcliffe was the only acute hospital in the town and dealt with all emergency admissions. In addition, we worked at the Churchill Hospital, then a hutted hospital, erected during the War to deal with Canadian military casualties and now handed over for civilian use. Elective orthopaedics was carried out at the Wingfield Morris Hospital, later the Nuffield Orthopaedic Centre. The patients here were mostly children with bone and joint tuberculosis or poliomyelitis. The Slade Isolation Hospital dealt with the infectious fevers; I was admitted there twice as a student, with first chicken pox and then measles, both caught from my patients! PMID:27290759</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3848118','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3848118"><span id="translatedtitle">Monozygotic twin <span class="hlt">sisters</span> discordant for familial hemiplegic migraine</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background The high concordance rate of migraine in monozygotic twin pairs has long been recognised. In the current study, we present a monozygotic twin pair discordant for familial hemiplegic migraine (FHM). Case presentations We evaluated 12 adult family members in 2012. The twin pair was separately examined by neurologists at different time points. Mutation screening was performed for known FHM-related genes. The monozygosity of the twins was verified. Eleven individuals had a history of migraine or paroxysmal neurological symptoms, including four patients with motor aura. No mutations were detected in the CACNA1A, ATP1A2, SCN1A, PRRT2 or NOTCH3 genes. The monozygotic twin <span class="hlt">sisters</span>, aged 52, were discordant for age of onset, motor aura and neuropsychological aura (forced thinking). Overall, the family members presented a wide range of phenotypical features. Conclusions Familial hemiplegic migraine is a monogenic disorder that is distinct from migraine with typical aura. However, in certain families with motor aura, such as this one, it is possible that the most severe phenotype is caused by an unlikely combination of polygenic traits and non-genetic factors. In these kindreds, we propose that hemiplegic aura is only a severe and complex form of typical aura. PMID:24041236</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15288052','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15288052"><span id="translatedtitle">A molecular test of alternative hypotheses of tetraodontiform (Acanthomorpha: Tetraodontiformes) <span class="hlt">sister</span> group relationships using data from the RAG1 gene.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Holcroft, Nancy I</p> <p>2004-09-01</p> <p>Two primary competing hypotheses regarding the identity of the <span class="hlt">sister</span> group of the order Tetraodontiformes exist. The first hypothesis holds that some or all acanthuroid fishes represent the <span class="hlt">sister</span> of Tetraodontiformes. The second, proposed in 1984 by Rosen, holds that the order Zeiformes is <span class="hlt">sister</span> to Tetraodontiformes and that the family Caproidae is <span class="hlt">sister</span> to this Zeiformes + Tetraodontiformes clade. These two hypotheses were tested using data from the single-copy nuclear gene RAG1. Representatives of most major orders of acanthomorph fishes were included to provide an appropriate context in which to place Tetraodontiformes and its hypothesized <span class="hlt">sister</span> groups. The results of an unweighted parsimony analysis indicate that Zeiformes is not the <span class="hlt">sister</span> group of Tetraodontiformes. In addition, Caproidae appears unrelated to Zeiformes. A monophyletic Tetraodontiformes was recovered as the <span class="hlt">sister</span> group of the clade Ephippidae + Drepanidae and was more distantly related to the included zeiform and caproid representatives. PMID:15288052</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/ency/article/001566.htm','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/ency/article/001566.htm"><span id="translatedtitle">Sudden infant <span class="hlt">death</span> syndrome</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Crib <span class="hlt">death</span>; SIDS ... However, SIDS is still a major cause of <span class="hlt">death</span> in infants under 1 year old. Thousands of ... affects boys more often than girls. Most SIDS <span class="hlt">deaths</span> occur in the winter. The following may increase ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23054426','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23054426"><span id="translatedtitle"><span class="hlt">Death</span>: 'nothing' gives insight.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ettema, Eric J</p> <p>2013-08-01</p> <p>According to a widely accepted belief, we cannot know our own <span class="hlt">death--death</span> means 'nothing' to us. At first sight, the meaning of 'nothing' just implies the negation or absence of 'something'. <span class="hlt">Death</span> then simply refers to the negation or absence of life. As a consequence, however, <span class="hlt">death</span> has no meaning of itself. This leads to an ontological paradox in which <span class="hlt">death</span> is both acknowledged and denied: <span class="hlt">death</span> is … nothing. In this article, I investigate whether insight into the ontological paradox of the nothingness of <span class="hlt">death</span> can contribute to a good end-of-life. By analysing Aquinas', Heidegger's and Derrida's understanding of <span class="hlt">death</span> as nothingness, I explore how giving meaning to <span class="hlt">death</span> on different ontological levels connects to, and at the same time provides resistance against, the harsh reality of <span class="hlt">death</span>. By doing so, I intend to demonstrate that insight into the nothingness of <span class="hlt">death</span> can count as a framework for a meaningful dealing with <span class="hlt">death</span>. PMID:23054426</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/suddeninfantdeathsyndrome.html','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/suddeninfantdeathsyndrome.html"><span id="translatedtitle">Sudden Infant <span class="hlt">Death</span> Syndrome</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Sudden infant <span class="hlt">death</span> syndrome (SIDS) is the sudden, unexplained <span class="hlt">death</span> of an infant younger than one year old. Some people call SIDS "crib <span class="hlt">death</span>" because many babies who die of SIDS are found in their ...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_7");'>7</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li class="active"><span>9</span></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_9 --> <div id="page_10" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="181"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3212099','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3212099"><span id="translatedtitle"><span class="hlt">Sister</span> Circles as a Culturally Relevant Intervention for Anxious African American Women</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Neal-Barnett, Angela; Stadulis, Robert; Murray, Marsheena; Payne, Margaret Ralston; Thomas, Anisha; Salley, Bernadette B.</p> <p>2011-01-01</p> <p>Research on anxiety treatment with African American women reveals a need to develop interventions that address factors relevant to their lives. Such factors include feelings of isolation, multiple roles undertaken by Black women, and faith. A recurrent theme across treatment studies is the importance of having support from other Black women. <span class="hlt">Sister</span> circles are support groups that build upon existing friendships, fictive kin networks, and the sense of community found among African Americans females. <span class="hlt">Sister</span> circles appear to offer many of the components Black women desire in an anxiety intervention. In this article, we explore <span class="hlt">sister</span> circles as an intervention for anxious African American women. Culturally-infused aspects from our <span class="hlt">sister</span> circle work with middle-class African American women are presented. Further research is needed. PMID:22081747</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol4/pdf/CFR-2012-title20-vol4-sec725-223.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol4/pdf/CFR-2012-title20-vol4-sec725-223.pdf"><span id="translatedtitle">20 CFR 725.223 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... the parent dies. (c) The last month for which such brother or <span class="hlt">sister</span> is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-223.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-223.pdf"><span id="translatedtitle">20 CFR 725.223 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... the parent dies. (c) The last month for which such brother or <span class="hlt">sister</span> is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2014-title20-vol4/pdf/CFR-2014-title20-vol4-sec725-223.pdf','CFR2014'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2014-title20-vol4/pdf/CFR-2014-title20-vol4-sec725-223.pdf"><span id="translatedtitle">20 CFR 725.223 - Duration of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2014&page.go=Go">Code of Federal Regulations, 2014 CFR</a></p> <p></p> <p>2014-04-01</p> <p>... the parent dies. (c) The last month for which such brother or <span class="hlt">sister</span> is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1128680','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1128680"><span id="translatedtitle">DNA single strand breakage, DNA adducts, and <span class="hlt">sister</span> chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Popp, W; Vahrenholz, C; Schell, C; Grimmer, G; Dettbarn, G; Kraus, R; Brauksiepe, A; Schmeling, B; Gutzeit, T; von Bülow, J; Norpoth, K</p> <p>1997-01-01</p> <p>OBJECTIVES: To investigate the specificity of biological monitoring variables (excretion of phenanthrene and pyrene metabolites in urine) and the usefulness of some biomarkers of effect (alkaline filter elution, 32P postlabelling assay, measurement of <span class="hlt">sister</span> chromatid exchange) in workers exposed to polycyclic aromatic hydrocarbons (PAHs). METHODS: 29 coke oven workers and a standardised control group were investigated for frequencies of DNA single strand breakage, DNA protein cross <span class="hlt">links</span> (alkaline filter elution assay), <span class="hlt">sister</span> chromatid exchange, and DNA adducts (32P postlabelling assay) in lymphocytes. Phenanthrene and pyrene metabolites were measured in 24 hour urine samples. 19 different PAHs (including benzo(a)pyrene, pyrene, and phenanthrene) were measured at the workplace by personal air monitoring. The GSTT1 activity in erythrocytes and lymphocyte subpopulations in blood was also measured. RESULTS: Concentrations of phenanthrene, pyrene, and benzo(a)pyrene in air correlated well with the concentration of total PAHs in air; they could be used for comparisons of different workplaces if the emission compositions were known. The measurement of phenanthrene metabolites in urine proved to be a better biological monitoring variable than the measurement of 1-hydroxypyrene. Significantly more DNA strand breaks in lymphocytes of coke oven workers were found (alkaline filter elution assay); the DNA adduct rate was not significantly increased in workers, but correlated with exposure to PAHs in a semiquantitative manner. The number of <span class="hlt">sister</span> chromatid exchanges was lower in coke oven workers but this was not significant; thus counting <span class="hlt">sister</span> chromatid exchanges was not a good variable for biomonitoring of coke oven workers. Also, indications for immunotoxic influences (changes in lymphocyte subpopulations) were found. CONCLUSIONS: The measurement of phenanthrene metabolites in urine seems to be a better biological monitoring variable for exposure to PAHs than</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4682810','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4682810"><span id="translatedtitle">Solution Radioactivated by Hadron Radiation Can Increase <span class="hlt">Sister</span> Chromatid Exchanges</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Maeda, Junko; Yurkon, Charles R.; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A.; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A.</p> <p>2015-01-01</p> <p>When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of <span class="hlt">sister</span> chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26657140','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26657140"><span id="translatedtitle">Solution Radioactivated by Hadron Radiation Can Increase <span class="hlt">Sister</span> Chromatid Exchanges.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Maeda, Junko; Yurkon, Charles R; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A</p> <p>2015-01-01</p> <p>When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of <span class="hlt">sister</span> chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27265374','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27265374"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchange assay as a predictor of tumor chemoresponse.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mourelatos, D</p> <p>2016-06-01</p> <p><span class="hlt">Sister</span> Chromatid Exchanges (SCEs) are known to enhance as a consequence of exposure to various mutagenic agents and appear to indicate DNA damaging effects and/or subsequent repair by homologous recombination (HR). DNA damage plays an interesting role in the majority of mechanisms underlying the effects of antitumor drugs, since the genetic activity of the plethora of these agents is due to their ability to damage the DNA. The DNA-effects of antitumor agents towards normal cells (genotoxicity) are great drawbacks of antitumor therapy and are connected to important adverse health effects in cancer patients undergoing chemotherapy. On the other hand, failure of chemotherapy in many cases is due to the DNA repair ability which cancer, like normal cells, also possess. As both DNA repair and genotoxic exposure are expected to vary among patients, correlating SCEs frequencies with only individual repair capacity may be feasible to predict. Cancer risk has not been observed to be associated with high SCEs levels. Since the administration of effective antitumor drugs with limited adverse effects is of great importance in the success of anticancer therapy, a lot of interest has been directed toward the development of methods and approaches that would enable the correct selection of appropriate drugs prior to the initiation of therapy on an individual basis. To this effect, more than 30 years ago, an investigation of the ability of the in vitro and the in vivo SCEs-assay to predict the in vitro and in vivo sensitivity of tumor cells to newly synthesized drugs or to those already in use began. In this short review a critical appraisal of the SCEs-assay as an important biomarker used for predicting cancer chemo-response as well as a summary of the key findings from several studies published within the last 20 years in this field is performed. PMID:27265374</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26621703','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26621703"><span id="translatedtitle">Genomic data do not support comb jellies as the <span class="hlt">sister</span> group to all other animals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert</p> <p>2015-12-15</p> <p>Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the <span class="hlt">sister</span> group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the <span class="hlt">sister</span> group to the remaining animals (the "Ctenophora-<span class="hlt">sister</span>" hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-<span class="hlt">sister</span>, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-<span class="hlt">sister</span> and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-<span class="hlt">sister</span> hypothesis are not supported by the currently available data. PMID:26621703</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=rose&pg=6&id=EJ1012746','ERIC'); return false;" href="http://eric.ed.gov/?q=rose&pg=6&id=EJ1012746"><span id="translatedtitle"><span class="hlt">Deaths</span> among Children, Adolescents, and Young Adults with Down Syndrome</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Miodrag, Nancy; Silverberg, Sophie E.; Urbano, Richard C.; Hodapp, Robert M.</p> <p>2013-01-01</p> <p>Background: Although life expectancies in Down syndrome (DS) have doubled over the past 3-4 decades, there continue to be many early <span class="hlt">deaths</span>. Yet, most research focuses on infant mortality or later adult <span class="hlt">deaths</span>. Materials and Methods: In this US study, hospital discharge and <span class="hlt">death</span> records from the state of Tennessee were <span class="hlt">linked</span> to examine 2046…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2003AGUFM.V32D1049C&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2003AGUFM.V32D1049C&link_type=ABSTRACT"><span id="translatedtitle">Silicic Eruptions of the Past 50 kyr at the Three <span class="hlt">Sisters</span> Volcanic Cluster</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Calvert, A. T.; Hildreth, W.; Fierstein, J.</p> <p>2003-12-01</p> <p>The Three <span class="hlt">Sisters</span> volcanic cluster in the central Oregon Cascades consists of mafic to intermediate stratovolcanoes surrounded by mafic and silicic flows and domes. The bulk of South and Middle <span class="hlt">Sister</span> are late Pleistocene while North <span class="hlt">Sister</span> is middle Pleistocene (Schmidt and Grunder, 2003 GSA abs.). Thick rhyolite and dacite lava flows and domes are rich in potassium, and young glaciation exposes holocrystalline groundmass textures ideal for argon geochronology. Several of these silicic flows bracket stratovolcano growth, and precise geochronology illuminates a rich basalt to rhyolite history in the cluster over the past 50 kyr. Careful step-heating 40Ar/39Ar experiments yield excellent plateau ages with radiogenic yields often above 5% on rocks as young as 20 ka. Most samples have well-determined isochrons with atmospheric (40/36 = 295.5) intercepts, although several have intercepts as low as 286. South <span class="hlt">Sister</span> is a composite cone with an andesite/dacite base (Hodge Crest) and a young andesite summit sequence. The basal flow of the 300m-thick, youngest conformable stack of andesite lavas at the summit is 27+/-3 ka. Unconformably underlying portions date back to at least 50 ka based on ages of overlapping silicic flows. The base of Middle <span class="hlt">Sister</span> is andesite overlain by ˜300m of olivine basalt. Some Middle <span class="hlt">Sister</span> andesites and all basalts overlie a distinctive dacite agglutinate (20+/-2 ka) in the South/Middle <span class="hlt">Sister</span> saddle. All Middle <span class="hlt">Sister</span> lavas underlie a thick dacite flow (14+/-3 ka) that vented at 8500 ft (2600m) on its S flank. Dacite lava flows erupted from the Middle/North <span class="hlt">Sister</span> saddle at 27+/-2 and 18+/-2 ka. Additionally, several >100m-thick rhyolite and dacite lavas vented low on the flanks of the cluster. Obsidian Cliff rhyolite (37.8+/-1.8 ka) and Lane Plateau dacite (21.4+/-1.9 ka) erupted W of Middle <span class="hlt">Sister</span>, the Dew Lake dacite (32.3+/-1.8 ka) located near the locus of the INSAR anomaly W of South <span class="hlt">Sister</span> flowed around a 148+/-4 ka (knob 6482) basalt</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3051424','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3051424"><span id="translatedtitle">Defining <span class="hlt">death</span>: organ transplants, tradition and technology in Japan.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Feldman, E A</p> <p>1988-01-01</p> <p>This article explores Japanese attitudes about brain <span class="hlt">death</span> and organ transplantation. First, ancient burial customs and <span class="hlt">death</span>-related rituals associated with Shinto and Buddhism are examined. Next, contemporary attitudes towards the dead are discussed in the context of current controversies surrounding brain <span class="hlt">death</span> and organ transplantation. Finally, an attempt is made to <span class="hlt">link</span> the traditional Japanese views of <span class="hlt">death</span> with modern medical dilemmas. PMID:3051424</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567865','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2567865"><span id="translatedtitle">Shugoshin1 May Play Important Roles in Separation of Homologous Chromosomes and <span class="hlt">Sister</span> Chromatids during Mouse Oocyte Meiosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Yin, Shen; Ai, Jun-Shu; Shi, Li-Hong; Wei, Liang; Yuan, Ju; Ouyang, Ying-Chun; Hou, Yi; Chen, Da-Yuan; Schatten, Heide; Sun, Qing-Yuan</p> <p>2008-01-01</p> <p>Background Homologous chromosomes separate in meiosis I and <span class="hlt">sister</span> chromatids separate in meiosis II, generating haploid gametes. To address the question why <span class="hlt">sister</span> chromatids do not separate in meiosis I, we explored the roles of Shogoshin1 (Sgo1) in chromosome separation during oocyte meiosis. Methodology/Principal Findings Sgo1 function was evaluated by exogenous overexpression to enhance its roles and RNAi to suppress its roles during two meioses of mouse oocytes. Immunocytochemistry and chromosome spread were used to evaluate phenotypes. The exogenous Sgo1 overexpression kept homologous chromosomes and <span class="hlt">sister</span> chromatids not to separate in meiosis I and meiosis II, respectively, while the Sgo1 RNAi promoted premature separation of <span class="hlt">sister</span> chromatids. Conclusions Our results reveal that prevention of premature separation of <span class="hlt">sister</span> chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of <span class="hlt">sister</span> chromatids in meiosis II requires loss of centromeric Sgo1. PMID:18949044</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.usgs.gov/of/2007/1221/','USGSPUBS'); return false;" href="http://pubs.usgs.gov/of/2007/1221/"><span id="translatedtitle">Digital Data for Volcano Hazards of the Three <span class="hlt">Sisters</span> Region, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Schilling, S.P.; Doelger, S.; Scott, W.E.; Iverson, R.M.</p> <p>2008-01-01</p> <p>Three <span class="hlt">Sisters</span> is one of three active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. The major composite volcanoes of this area are clustered near the center of the region and include South <span class="hlt">Sister</span>, Middle <span class="hlt">Sister</span>, and Broken Top. Additionally, hundreds of mafic volcanoes are scattered throughout the Three <span class="hlt">Sisters</span> area. These range from small cinder cones to large shield volcanoes like North <span class="hlt">Sister</span> and Belknap Crater. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three <span class="hlt">Sisters</span> and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three <span class="hlt">Sisters</span> and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the Cascade Range also contribute to volcano hazards in Central Oregon. Scientists at the Cascades Volcano Observatory created a geographic information system (GIS) data set which depicts proximal and distal lahar hazard zones as well as a regional lava flow hazard zone for Three <span class="hlt">Sisters</span> (USGS Open-File Report 99-437, Scott and others, 1999). The various distal lahar zones were constructed from LaharZ software using 20, 100, and 500 million cubic meter input flow volumes. Additionally, scientists used the depositional history of past events in the Three <span class="hlt">Sisters</span> Region as well as experience and judgment derived from the</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25194162','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25194162"><span id="translatedtitle"><span class="hlt">Sisters</span> unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krishnan, Badri; Thomas, Sharon E; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B; McKee, Bruce D</p> <p>2014-11-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4687580','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4687580"><span id="translatedtitle">Genomic data do not support comb jellies as the <span class="hlt">sister</span> group to all other animals</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert</p> <p>2015-01-01</p> <p>Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the <span class="hlt">sister</span> group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the <span class="hlt">sister</span> group to the remaining animals (the “Ctenophora-sister” hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-<span class="hlt">sister</span>, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-<span class="hlt">sister</span> and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-<span class="hlt">sister</span> hypothesis are not supported by the currently available data. PMID:26621703</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27170622','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27170622"><span id="translatedtitle">High density of REC8 constrains <span class="hlt">sister</span> chromatid axes and prevents illegitimate synaptonemal complex formation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer</p> <p>2016-06-01</p> <p>During meiosis, cohesin complexes mediate <span class="hlt">sister</span> chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged <span class="hlt">sister</span> chromatid axes in mouse meiocytes that have normal or reduced levels of cohesin complexes, assessing the relationship between localization of cohesin complexes, SCC and SC formation. We show that REC8 foci are separated from each other by a distance smaller than 15% of the total chromosome axis length in wild-type meiocytes. Reduced levels of cohesin complexes result in a local separation of <span class="hlt">sister</span> chromatid axial elements (LSAEs), as well as illegitimate SC formation at these sites. REC8 but not RAD21 or RAD21L cohesin complexes flank sites of LSAEs, whereas RAD21 and RAD21L appear predominantly along the separated <span class="hlt">sister</span>-chromatid axes. Based on these observations and a quantitative distribution analysis of REC8 along <span class="hlt">sister</span> chromatid axes, we propose that the high density of randomly distributed REC8 cohesin complexes promotes SCC and prevents illegitimate SC formation. PMID:27170622</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3033573','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3033573"><span id="translatedtitle"><span class="hlt">Sister</span> cohesion and structural axis components mediate homolog bias of meiotic recombination</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kim, Keun P.; Weiner, Beth M.; Zhang, Liangran; Jordan, Amy; Dekker, Job; Kleckner, Nancy</p> <p>2010-01-01</p> <p>SUMMARY Meiotic recombination occurs between one chromatid of each maternal and paternal homolog (homolog bias) versus between <span class="hlt">sister</span> chromatids (<span class="hlt">sister</span> bias). Physical DNA analysis reveals that meiotic cohesin/axis component Rec8 promotes <span class="hlt">sister</span> bias, likely via its cohesion activity. Two meiosis-specific axis components, Red1/Mek1kinase, counteract this effect. With this precondition satisfied, other molecules directly specify homolog bias per se. Rec8 also acts positively to maintain homolog bias during crossover recombination. These observations point to sequential release of double-strand break ends from association with their <span class="hlt">sister</span>. Red1 and Rec8 are found to play distinct roles for <span class="hlt">sister</span> cohesion, DSB formation and recombination progression kinetics. Also, the two components are enriched in spatially distinct domains of axial structure that develop prior to DSB formation. We propose that Red1 and Rec8 domains provide functionally complementary environments whereby inputs evolved from DSB repair and late-stage chromosome morphogenesis are integrated to give the complete meiotic chromosomal program. PMID:21145459</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4224182"><span id="translatedtitle"><span class="hlt">Sisters</span> Unbound Is Required for Meiotic Centromeric Cohesion in Drosophila melanogaster</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Krishnan, Badri; Thomas, Sharon E.; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B.; McKee, Bruce D.</p> <p>2014-01-01</p> <p>Regular meiotic chromosome segregation requires <span class="hlt">sister</span> centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when <span class="hlt">sister</span> chromatids segregate. Both orientation patterns require cohesion between <span class="hlt">sister</span> centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called <span class="hlt">sisters</span> unbound (sunn), which is required for stable <span class="hlt">sister</span> chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7773517','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7773517"><span id="translatedtitle">The management of professionals: the preferences of hospital <span class="hlt">sisters</span> and charge nurses.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Foster, D</p> <p>1995-05-01</p> <p>This analysis of the preferences of how <span class="hlt">sisters</span> and charge nurses are managed is the result of a two centre descriptive study using theoretical models of professionalism, developing preferences and exercising situational leadership. It was conducted to determine if the management structure preferred by <span class="hlt">sisters</span> and charge nurses, in a general acute hospital setting, supported the professionalism of nursing. The outcomes were intended to help develop a strategic plan for the future of nursing and the management of nurses. The research instruments were a self-completed questionnaire (19 were returned, a response rate of 31.1%) and four semi-structured interviews. The findings disclosed some dissatisfaction with the present management arrangements. The <span class="hlt">sisters</span> and charge nurses felt that their priorities for practice and professional issues were better supported by clinically involved, ward-based senior nurses than by unit-based senior nurses with a general management function. However, <span class="hlt">sisters</span>' and charge nurses' discussions with ward-based senior nurses were apparently less effective than discussions in peer groups which led to influential collegial autonomy. This preferred management style can be supported by the use of situational leadership theory which would enhance collegial autonomy and professional satisfaction. Recognition of the <span class="hlt">sisters</span> and charge nurses preferences and adjustment of their management would therefore enable them to participate effectively in organizational decision-making. PMID:7773517</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_8");'>8</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li class="active"><span>10</span></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_10 --> <div id="page_11" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="201"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1012606','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1012606"><span id="translatedtitle">Autosomal recessive sudden unexpected <span class="hlt">death</span> in children probably caused by a cardiomyopathy associated with myopathy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fried, K; Beer, S; Vure, E; Algom, M; Shapira, Y</p> <p>1979-01-01</p> <p>The propositus, who died suddenly at the age of 22 months, was investigated because of an unusual myopathy. Family history revealed two <span class="hlt">sisters</span> and four cousins who had also died suddenly and unexpectedly. The finding of asymmetric septal hypertrophy by echocardiography in the propositus suggested that the cause of the sudden <span class="hlt">death</span> in the relatives was an undetected cardiomyopathy accompanying a mild and often subclinical myopathy. The affected children were in two sibships and both sets of parents were first cousins. The mother of one sibship was the <span class="hlt">sister</span> of the father of the other. It is suggested that a gene causes a mild autosomal recessive myopathy with cardiomyopathy that is often undiagnosed and usually ends in sudden unexpected <span class="hlt">death</span> in the second year of life. The same gene may manifest on echocardiogram in some heterozygotes as asymmetric septal hypertrophy. Images PMID:513079</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7771381','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7771381"><span id="translatedtitle"><span class="hlt">Death</span> by fraternity hazing.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Boglioli, L R; Taff, M L</p> <p>1995-03-01</p> <p>Fraternity hazing can cause a variety of injuries and <span class="hlt">deaths</span>. We recently had the opportunity to investigate a heat-related <span class="hlt">death</span> that occurred during a college fraternity event. The original <span class="hlt">death</span> investigation did not consider the circumstances of <span class="hlt">death</span>, environmental conditions, or the subtle autopsy findings related to heat stroke. This case is intended to alert health care professionals that <span class="hlt">deaths</span> on college campuses may be related to fraternity hazing and may require in-depth investigations. An analysis of the <span class="hlt">death</span> and a discussion of heat-related injuries are presented. PMID:7771381</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23076835','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23076835"><span id="translatedtitle">Using a sibling design to compare childhood adversities in female patients with BPD and their <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer; Correa, José A</p> <p>2012-11-01</p> <p>Abuse and neglect are well-established risk correlates of borderline personality disorder (BPD). The goal of this study was to examine whether BPD probands can be differentiated from their <span class="hlt">sisters</span> with respect to a range of developmental adversity and maltreatment indicators, including retrospective self-reports of past experiences of childhood abuse and neglect, dysfunctional parent-child relationships and peer victimization and dysfunctional peer relationships. A total of 53 patients with BPD were compared to 53 <span class="hlt">sisters</span> who were currently free of psychopathology on measures assessing childhood adversities. Both probands and <span class="hlt">sisters</span> reported similar prevalence of intrafamilial abuse, although BPD patients reported more severe physical and emotional abuse. BPD patients reported higher prevalence of physical abuse by peers. These findings generally support the principle of multifinality, in which similar histories of adversities can be associated with a variety of outcomes, ranging from psychopathology to resilience. PMID:23076835</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005NW.....92..586B&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005NW.....92..586B&link_type=ABSTRACT"><span id="translatedtitle">Osteological evidence for <span class="hlt">sister</span> group relationship between pseudo-toothed birds (Aves: Odontopterygiformes) and waterfowls (Anseriformes)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bourdon, Estelle</p> <p>2005-12-01</p> <p>The phylogenetic affinities of the extinct pseudo-toothed birds have remained controversial. Some authors noted that they resemble both pelicans and allies (Pelecaniformes) and tube-nosed birds (Procellariiformes), but assigned them to a distinct taxon, the Odontopterygiformes. In most recent studies, the pseudo-toothed birds are referred to the family Pelagornithidae inside the Pelecaniformes. Here, I perform a cladistic analysis with five taxa of the pseudo-toothed birds including two undescribed new species from the Early Tertiary of Morocco. The present hypothesis strongly supports a <span class="hlt">sister</span> group relationship of pseudo-toothed birds (Odontopterygiformes) and waterfowls (Anseriformes). The Odontoanserae (Odontopterygiformes plus Anseriformes) are the <span class="hlt">sister</span> group of Neoaves. The placement of the landfowls (Galliformes) as the <span class="hlt">sister</span> taxon of all other neognathous birds does not support the consensus view that the Galloanserae (Galliformes plus Anseriformes) are monophyletic.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21479528','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21479528"><span id="translatedtitle">Bartter syndrome in two <span class="hlt">sisters</span> with a novel mutation of the CLCNKB gene, one with deafness.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robitaille, Pierre; Merouani, Aicha; He, Ning; Pei, York</p> <p>2011-09-01</p> <p>This article describes two <span class="hlt">sisters</span> with type III Bartter syndrome (BS) due to a novel missense variant of the CLCNKB gene. The phenotypic expression of the disease was very different in these two siblings. In one <span class="hlt">sister</span>, the disease followed a very severe course, especially in the neonatal period and as a toddler. Both the classic symptoms and the biochemical features of the syndrome were striking. In addition, she presented with sensorineural deafness, a complication yet unreported in this subtype of BS In contrast, the least affected <span class="hlt">sister</span> was symptom free and the biochemical features of the disease although present remained discrete throughout the prolonged follow-up. It is suggested that such a difference in the phenotypic expression of the disease is possibly secondary to the modifier effect of a gene and/or results from environmental factor(s). PMID:21479528</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/suddeninfantdeathsyndrome.html','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/suddeninfantdeathsyndrome.html"><span id="translatedtitle">Sudden Infant <span class="hlt">Death</span> Syndrome</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Sudden infant <span class="hlt">death</span> syndrome (SIDS) is the sudden, unexplained <span class="hlt">death</span> of an infant younger than one year old. Some people call ... boys, African Americans, and American Indian/Alaska Native infants have a higher risk of SIDS. Although health ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116"><span id="translatedtitle">Single mitochondrial gene barcodes reliably identify <span class="hlt">sister</span>-species in diverse clades of birds</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2008-01-01</p> <p>Background DNA barcoding of life using a standardized COI sequence was proposed as a species identification system, and as a method for detecting putative new species. Previous tests in birds showed that individuals can be correctly assigned to species in ~94% of the cases and suggested a threshold of 10× mean intraspecific difference to detect potential new species. However, these tests were criticized because they were based on a single maternally inherited gene rather than multiple nuclear genes, did not compare phylogenetically identified <span class="hlt">sister</span> species, and thus likely overestimated the efficacy of DNA barcodes in identifying species. Results To test the efficacy of DNA barcodes we compared ~650 bp of COI in 60 <span class="hlt">sister</span>-species pairs identified in multigene phylogenies from 10 orders of birds. In all pairs, individuals of each species were monophyletic in a neighbor-joining (NJ) tree, and each species possessed fixed mutational differences distinguishing them from their <span class="hlt">sister</span> species. Consequently, individuals were correctly assigned to species using a statistical coalescent framework. A coalescent test of taxonomic distinctiveness based on chance occurrence of reciprocal monophyly in two lineages was verified in known <span class="hlt">sister</span> species, and used to identify recently separated lineages that represent putative species. This approach avoids the use of a universal distance cutoff which is invalidated by variation in times to common ancestry of <span class="hlt">sister</span> species and in rates of evolution. Conclusion Closely related <span class="hlt">sister</span> species of birds can be identified reliably by barcodes of fixed diagnostic substitutions in COI sequences, verifying coalescent-based statistical tests of reciprocal monophyly for taxonomic distinctiveness. Contrary to recent criticisms, a single DNA barcode is a rapid way to discover monophyletic lineages within a metapopulation that might represent undiscovered cryptic species, as envisaged in the unified species concept. This identifies a smaller</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24362571','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24362571"><span id="translatedtitle">RecA bundles mediate homology pairing between distant <span class="hlt">sisters</span> during DNA break repair.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J</p> <p>2014-02-13</p> <p>DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant <span class="hlt">sister</span> loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one <span class="hlt">sister</span> can be repaired efficiently using distant <span class="hlt">sister</span> homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut <span class="hlt">sister</span>. After <span class="hlt">sister</span> locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in <span class="hlt">sister</span> pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions. PMID:24362571</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014Natur.506..249L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014Natur.506..249L"><span id="translatedtitle">RecA bundles mediate homology pairing between distant <span class="hlt">sisters</span> during DNA break repair</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J.</p> <p>2014-02-01</p> <p>DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant <span class="hlt">sister</span> loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one <span class="hlt">sister</span> can be repaired efficiently using distant <span class="hlt">sister</span> homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut <span class="hlt">sister</span>. After <span class="hlt">sister</span> locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in <span class="hlt">sister</span> pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED076237.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED076237.pdf"><span id="translatedtitle">Children's Experience with <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Zeligs, Rose</p> <p></p> <p>Children's concepts of <span class="hlt">death</span> grow with their age and development The three-year-old begins to notice that living things move and make sounds. The five-year-old thinks that life and <span class="hlt">death</span> are reversable, but the six-year-old knows that <span class="hlt">death</span> is final and brings sorrow. Children from eight through ten are interested in the causes of <span class="hlt">death</span> and what…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2595665','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2595665"><span id="translatedtitle">Sudden Cardiac <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Weinberg, Marc</p> <p>1978-01-01</p> <p>Over the past decade, there has been a significant decrease in the hospital mortality of patients with coronary artery disease. However, sudden cardiac <span class="hlt">death</span>, which accounts for the majority of <span class="hlt">deaths</span> from coronary artery disease, hasbeen little affected. This report reviews the pathology, electrophysiology, demographics and clinical presentation of sudden cardiac <span class="hlt">death</span>. Emergency care and possible preventative measures are examined. PMID:356435</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=sleep+AND+dreams&pg=5&id=EJ381557','ERIC'); return false;" href="http://eric.ed.gov/?q=sleep+AND+dreams&pg=5&id=EJ381557"><span id="translatedtitle">Dreams of <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Barrett, Deirdre</p> <p>1989-01-01</p> <p>Examined frequency and characteristics of overt dreams of dying among healthy young adults. Dreams of dying were found to be rare but distinctive content category, representing overwhelmingly pleasant dreams. Over one-half of <span class="hlt">death</span> dreams involved lengthy afterlife sequence, remainder focused on process of <span class="hlt">death</span>. <span class="hlt">Death</span> dreams of these healthy…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=consolation&pg=2&id=EJ556677','ERIC'); return false;" href="http://eric.ed.gov/?q=consolation&pg=2&id=EJ556677"><span id="translatedtitle">Separation, Part I: <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Jordan, Anne Devereaux</p> <p>1997-01-01</p> <p>Contends literature is the one place where <span class="hlt">death</span> still abides, where grief is felt and consolation can be sought. States that young readers can gain a recognition in books that <span class="hlt">death</span> is natural. Discusses <span class="hlt">death</span> in folk and fairy tales, in 17th-century didactic children's books and in modern and contemporary literature. Outlines characteristics of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&id=EJ927986','ERIC'); return false;" href="http://eric.ed.gov/?q=death&id=EJ927986"><span id="translatedtitle">Evidence That Thinking about <span class="hlt">Death</span> Relates to Time-Estimation Behavior</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Martens, Andy; Schmeichel, Brandon J.</p> <p>2011-01-01</p> <p>Time and <span class="hlt">death</span> are <span class="hlt">linked</span>--the passing of time brings us closer to <span class="hlt">death</span>. Terror management theory proposes that awareness of <span class="hlt">death</span> represents a potent problem that motivates a variety of psychological defenses (Greenberg, Pyszczynski, & Solomon, 1997). We tested the hypothesis that thinking about <span class="hlt">death</span> motivates elongated perceptions of brief…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25642921','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25642921"><span id="translatedtitle">Infant <span class="hlt">death</span> scene investigation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tabor, Pamela D; Ragan, Krista</p> <p>2015-01-01</p> <p>The sudden unexpected <span class="hlt">death</span> of an infant is a tragedy to the family, a concern to the community, and an indicator of national health. To accurately determine the cause and manner of the infant's <span class="hlt">death</span>, a thorough and accurate <span class="hlt">death</span> scene investigation by properly trained personnel is key. Funding and resources are directed based on autopsy reports, which are only as accurate as the scene investigation. The investigation should include a standardized format, body diagrams, and a photographed or videotaped scene recreation utilizing doll reenactment. Forensic nurses, with their basic nursing knowledge and additional forensic skills and abilities, are optimally suited to conduct infant <span class="hlt">death</span> scene investigations as well as train others to properly conduct <span class="hlt">death</span> scene investigations. Currently, 49 states have child <span class="hlt">death</span> review teams, which is an idea avenue for a forensic nurse to become involved in <span class="hlt">death</span> scene investigations. PMID:25642921</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4307833','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4307833"><span id="translatedtitle">Effect of Cause-of-<span class="hlt">Death</span> Training on Agreement Between Hospital Discharge Diagnoses and Cause of <span class="hlt">Death</span> Reported, Inpatient Hospital <span class="hlt">Deaths</span>, New York City, 2008–2010</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ong, Paulina; Gambatese, Melissa; Begier, Elizabeth; Zimmerman, Regina; Soto, Antonio</p> <p>2015-01-01</p> <p>Introduction Accurate cause-of-<span class="hlt">death</span> reporting is required for mortality data to validly inform public health programming and evaluation. Research demonstrates overreporting of heart disease on New York City <span class="hlt">death</span> certificates. We describe changes in reported causes of <span class="hlt">death</span> following a New York City health department training conducted in 2009 to improve accuracy of cause-of-<span class="hlt">death</span> reporting at 8 hospitals. The objective of our study was to assess the degree to which <span class="hlt">death</span> certificates citing heart disease as cause of <span class="hlt">death</span> agreed with hospital discharge data and the degree to which training improved accuracy of reporting. Methods We analyzed 74,373 <span class="hlt">death</span> certificates for 2008 through 2010 that were <span class="hlt">linked</span> with hospital discharge records for New York City inpatient <span class="hlt">deaths</span> and calculated the proportion of discordant <span class="hlt">deaths</span>, that is, <span class="hlt">death</span> certificates reporting an underlying cause of heart disease with no corresponding discharge record diagnosis. We also summarized top principal diagnoses among discordant reports and calculated the proportion of inpatient <span class="hlt">deaths</span> reporting sepsis, a condition underreported in New York City, to assess whether documentation practices changed in response to clarifications made during the intervention. Results Citywide discordance between <span class="hlt">death</span> certificates and discharge data decreased from 14.9% in 2008 to 9.6% in 2010 (P < .001), driven by a decrease in discordance at intervention hospitals (20.2% in 2008 to 8.9% in 2010; P < .001). At intervention hospitals, reporting of sepsis increased from 3.7% of inpatient <span class="hlt">deaths</span> in 2008 to 20.6% in 2010 (P < .001). Conclusion Overreporting of heart disease as cause of <span class="hlt">death</span> declined at intervention hospitals, driving a citywide decline, and sepsis reporting practices changed in accordance with health department training. Researchers should consider the effect of overreporting and data-quality changes when analyzing New York City heart disease mortality trends. Other vital records jurisdictions</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575"><span id="translatedtitle">Super-resolution kinetochore tracking reveals the mechanisms of human <span class="hlt">sister</span> kinetochore directional switching</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Burroughs, Nigel J; Harry, Edward F; McAinsh, Andrew D</p> <p>2015-01-01</p> <p>The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated <span class="hlt">sister</span> kinetochores. <span class="hlt">Sister</span> kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin. A crucial question is to understand how <span class="hlt">sister</span> kinetochores are coordinated to generate motility and directional switches. Here, we combine super-resolution tracking of kinetochores with automated switching-point detection to analyse <span class="hlt">sister</span> switching dynamics over thousands of events. We discover that switching is initiated by both the leading (microtubules depolymerising) or trailing (microtubules polymerising) kinetochore. Surprisingly, trail-driven switching generates an overstretch of the chromatin that relaxes over the following half-period. This rules out the involvement of a tension sensor, the central premise of the long-standing tension-model. Instead, our data support a model in which clocks set the intrinsic-switching time of the two kinetochore-attached microtubule fibres, with the centromeric spring tension operating as a feedback to slow or accelerate the clocks. DOI: http://dx.doi.org/10.7554/eLife.09500.001 PMID:26460545</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Brother+AND+analysis&pg=4&id=EJ818749','ERIC'); return false;" href="http://eric.ed.gov/?q=Brother+AND+analysis&pg=4&id=EJ818749"><span id="translatedtitle">Improving Emotion Regulation and Sibling Relationship Quality: The More Fun with <span class="hlt">Sisters</span> and Brothers Program</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kennedy, Denise E.; Kramer, Laurie</p> <p>2008-01-01</p> <p>We examined the role of emotion regulation (ER) in improving sibling relationship quality (SRQ) by evaluating the More Fun With <span class="hlt">Sisters</span> and Brothers Program where 4- to 8-year-old siblings from 95 families were taught emotional and social competencies. Parents reported on SRQ and ER, and sibling interactions were observed in homes. SRQ and ER…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED503245','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED503245"><span id="translatedtitle">Making a Difference in Schools: The Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring Impact Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; Feldman, Amy F.; McMaken, Jennifer</p> <p>2007-01-01</p> <p>School-based mentoring is one of the fastest growing forms of mentoring in the US today; yet, few studies have rigorously examined its impacts. This landmark random assignment impact study of Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring is the first national study of this program model. It involves 10 agencies, 71 schools and 1,139 9- to…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED205747.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED205747.pdf"><span id="translatedtitle">Variations in the Educational and Career Development Paths of Brothers and <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mott, Frank L.; Haurin, R. Jean</p> <p></p> <p>A study examined the extent to which socioeconomic and internal characteristics of families differentially affect ability of matched pairs of brothers and <span class="hlt">sisters</span> to progress through the educational system. The data sets used were the National Longitudinal Surveys of Work Experience of Young Men and Women who were originally interviewed in 1966…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_9");'>9</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li class="active"><span>11</span></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_11 --> <div id="page_12" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="221"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED266892','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED266892"><span id="translatedtitle">Walking with Grandfather and Great Wolf and Little Mouse <span class="hlt">Sister</span>. Teacher's Guide.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lethbridge Univ. (Alberta).</p> <p></p> <p>Written for use with videotaped versions of the stories "Walking with Grandfather" and "Great Wolf and Little Mouse <span class="hlt">Sister</span>," this guide presents 20 lessons that teachers can adapt for students of various ages and use in integrated units or other curriculum approaches. The introductory material describes the use and philosophy of the video stories,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=older+AND+brother&pg=2&id=EJ618677','ERIC'); return false;" href="http://eric.ed.gov/?q=older+AND+brother&pg=2&id=EJ618677"><span id="translatedtitle">The Role of Brothers and <span class="hlt">Sisters</span> in the Gender Development of Preschool Children.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rust, John; Golombok, Susan; Hines, Melissa; Johnston, Katie; Golding, Jean</p> <p>2000-01-01</p> <p>Examined whether the sex of older siblings influenced the gender role development of 3-year-olds. Found that boys with older brothers and girls with older <span class="hlt">sisters</span> were more sex-typed than same-sex singletons who, in turn, were more sex-typed than children with other-sex siblings. Having an older brother was associated with more masculine and less…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Families&pg=5&id=EJ1088123','ERIC'); return false;" href="http://eric.ed.gov/?q=Families&pg=5&id=EJ1088123"><span id="translatedtitle">Living with a Brother Who Has an Autism Spectrum Disorder: A <span class="hlt">Sister</span>'s Perspective</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Connell, Zara O.; Halloran, Maeve O.; Doody, Owen</p> <p>2016-01-01</p> <p>People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or <span class="hlt">sister</span>. Services for people with ASD should provide effective support to families, which include brothers,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=deal+AND+bullying&pg=3&id=EJ830840','ERIC'); return false;" href="http://eric.ed.gov/?q=deal+AND+bullying&pg=3&id=EJ830840"><span id="translatedtitle">Brothers and <span class="hlt">Sisters</span>: A Source of Support for Children in School?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie</p> <p>2006-01-01</p> <p>Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and <span class="hlt">sisters</span> becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=daughter&pg=5&id=EJ1011495','ERIC'); return false;" href="http://eric.ed.gov/?q=daughter&pg=5&id=EJ1011495"><span id="translatedtitle">Brother-<span class="hlt">Sister</span> Incest: Data from Anonymous Computer-Assisted Self Interviews</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Whelan, Nathan V.; Kocot, Kevin M.; Moroz, Leonid L.</p> <p>2015-01-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567','ERIC'); return false;" href="http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567"><span id="translatedtitle">Social Functioning among Girls with Fragile X or Turner Syndrome and Their <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.</p> <p>1998-01-01</p> <p>Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their <span class="hlt">sisters</span>, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1006061.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1006061.pdf"><span id="translatedtitle">Catherine Spalding: Co-Foundress of the <span class="hlt">Sisters</span> of Charity of Nazareth</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shaughnessy, Mary Angela</p> <p>2006-01-01</p> <p>The <span class="hlt">Sisters</span> of Charity of Nazareth (SCN) maintain a vibrant presence in ministry in the US. This article presents an overview of their co-foundress, Catherine Spalding, and shows Mother Catherine to be the creative, mission-driven, and articulate leader that is still very much in need in today's society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25902535','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25902535"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Whelan, Nathan V; Kocot, Kevin M; Moroz, Leonid L; Halanych, Kenneth M</p> <p>2015-05-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-380.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-380.pdf"><span id="translatedtitle">20 CFR 410.380 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-340.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol2/pdf/CFR-2010-title20-vol2-sec410-340.pdf"><span id="translatedtitle">20 CFR 410.340 - Determination of relationship; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of relationship; parent, brother, or <span class="hlt">sister</span>. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=summer+AND+camp+AND+benefits&pg=3&id=EJ587581','ERIC'); return false;" href="http://eric.ed.gov/?q=summer+AND+camp+AND+benefits&pg=3&id=EJ587581"><span id="translatedtitle"><span class="hlt">Sisters</span> in Science: An Intergenerational Science Program for Elementary School Girls.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.</p> <p>1998-01-01</p> <p>Once a week, several classrooms of Philadelphia 4th-grade girls participate in <span class="hlt">Sisters</span> in Science, an afterschool, intergenerational program sponsored by Temple University that provides hand-on activities exploring urban environmental issues. A two-week summer camp program helps these students explore the rivers of Philadelphia. Participants…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=testimonio&pg=3&id=EJ903417','ERIC'); return false;" href="http://eric.ed.gov/?q=testimonio&pg=3&id=EJ903417"><span id="translatedtitle">Transitioning from Doctoral Study to the Academy: Theorizing "Trenzas" of Identity for Latina <span class="hlt">Sister</span> Scholars</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Espino, Michelle M.; Munoz, Susana M.; Kiyama, Judy Marquez</p> <p>2010-01-01</p> <p>This article focuses on multiple truths pertaining to doctoral education as expressed by three Latina doctoral recipients. These scholars successfully navigated various educational processes with the support of one another, their families, faculty, and their chosen discipline. The authors, as <span class="hlt">sister</span> scholars, retell their educational journeys…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356"><span id="translatedtitle">Spotlights on our <span class="hlt">sister</span> journals: ChemistryOpen 1/2014</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>On these pages, we feature a selection of the excellent work that has recently been published in our <span class="hlt">sister</span> journals. If you are reading these pages on a computer, click on any of the items to read the full article. Otherwise please see the DOIs for easy online access through Wiley Online Library. PMID:24688888</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=bilingual+AND+children+AND+home&pg=5&id=EJ997719','ERIC'); return false;" href="http://eric.ed.gov/?q=bilingual+AND+children+AND+home&pg=5&id=EJ997719"><span id="translatedtitle">A Tale of Three <span class="hlt">Sisters</span>: Language Ideologies, Identities, and Negotiations in a Bilingual, Transnational Family</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Kendall A.</p> <p>2013-01-01</p> <p>This longitudinal case study investigated how linguistic identity was constructed, constrained, and performed by three <span class="hlt">sisters</span>, aged 1, 12, and 17, within one bilingual, transnational Ecuadorian-U.S. family. Data were collected over 14 months through weekly home visits that included participant observation, informal interviews, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-340.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-340.pdf"><span id="translatedtitle">20 CFR 410.340 - Determination of relationship; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of relationship; parent, brother, or <span class="hlt">sister</span>. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-380.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol2/pdf/CFR-2011-title20-vol2-sec410-380.pdf"><span id="translatedtitle">20 CFR 410.380 - Determination of dependency; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or <span class="hlt">sister</span>. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol16/pdf/CFR-2010-title40-vol16-sec79-65.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol16/pdf/CFR-2010-title40-vol16-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H... peripheral blood lymphocytes, often from rodent species. (b) Definitions. For the purposes of this section... the end of the exposure period and blood lymphocyte cell cultures are prepared from study...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6704889','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6704889"><span id="translatedtitle">Do <span class="hlt">sister</span> forks of bidirectionally growing replicons proceed at unequal rates</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dubey, D.D.; Raman, R.</p> <p>1987-02-01</p> <p>DNA fibre autoradiography in different tissues of the rodents Bandicota bengalensis and Nesokia indica reveals a high frequency of such bidirectionally replicating replicons whose <span class="hlt">sister</span> hot tracks are of unequal size. These results suggest intrarepliconic difference in the rates of fork migration in the two directions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780','ERIC'); return false;" href="http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780"><span id="translatedtitle">Three <span class="hlt">Sisters</span>: Lessons of Traditional Story Honored in Assessment and Accreditation</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenault, Venida S.</p> <p>2008-01-01</p> <p>The three <span class="hlt">sisters</span> story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in tribal…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_10");'>10</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li class="active"><span>12</span></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_12 --> <div id="page_13" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="241"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=258716','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=258716"><span id="translatedtitle">A <span class="hlt">sister</span> group metabolomic contrast delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Understanding how plant cells tolerate dehydration is a vital prerequisite for developing strategies for improving drought tolerance. The desiccation tolerant grass Sporobolus stapfianus and the desiccation sensitive S. pyramidalis were used to form a <span class="hlt">sister</span>-group contrast to reveal adaptive metabo...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/14984173','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/14984173"><span id="translatedtitle">Capillaria philippinensis: a cause of fatal diarrhea in one of two infected Egyptian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>el-Karaksy, Hanaa; el-Shabrawi, Mortada; Mohsen, Nabil; Kotb, Magd; el-Koofy, Nehal; el-Deeb, Nadia</p> <p>2004-02-01</p> <p>Capillaria philippinensis is an emerging infection in Egypt. Reports in children are scarce. We report here two <span class="hlt">sisters</span> with C. philippinensis infection, aged 8 and 12 years. Their father was a fisherman and they had a habit of picking small pieces of uncooked fish to eat while their mother prepared their meals. They came from El-Menia governorate, which lies in the northern part of Upper Egypt. Most reported cases from Egypt come from this governorate and nearby areas. Both <span class="hlt">sisters</span> had persistent profuse watery diarrhea of 12 months' duration. Their weights were below the 5th percentile for age. Both were hypoalbuminemic, but only the younger had pedal edema. Both had hypokalemia and hyponatremia. During the course of their illness they were repeatedly admitted to different hospitals and received intravenous fluids, but the correct diagnosis was not reached. Diagnosis was made by stool examination at our hospital when eggs and larvae were detected in stool samples. Although a diagnosis was promptly made, the older <span class="hlt">sister</span> who suffered from pneumonia and septic shock unfortunately died a few days after admission. The younger <span class="hlt">sister</span> was treated successfully with albendazole 200 mg twice daily. Diarrhea abated, pedal edema disappeared, and she started to gain weight. PMID:14984173</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066400','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066400"><span id="translatedtitle">Tension-dependent removal of pericentromeric shugoshin is an indicator of <span class="hlt">sister</span> chromosome biorientation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nerusheva, Olga O.; Galander, Stefan; Fernius, Josefin; Kelly, David; Marston, Adele L.</p> <p>2014-01-01</p> <p>During mitosis and meiosis, <span class="hlt">sister</span> chromatid cohesion resists the pulling forces of microtubules, enabling the generation of tension at kinetochores upon chromosome biorientation. How tension is read to signal the bioriented state remains unclear. Shugoshins form a pericentromeric platform that integrates multiple functions to ensure proper chromosome biorientation. Here we show that budding yeast shugoshin Sgo1 dissociates from the pericentromere reversibly in response to tension. The antagonistic activities of the kinetochore-associated Bub1 kinase and the Sgo1-bound phosphatase protein phosphatase 2A (PP2A)-Rts1 underlie a tension-dependent circuitry that enables Sgo1 removal upon <span class="hlt">sister</span> kinetochore biorientation. Sgo1 dissociation from the pericentromere triggers dissociation of condensin and Aurora B from the centromere, thereby stabilizing the bioriented state. Conversely, forcing <span class="hlt">sister</span> kinetochores to be under tension during meiosis I leads to premature Sgo1 removal and precocious loss of pericentromeric cohesion. Overall, we show that the pivotal role of shugoshin is to build a platform at the pericentromere that attracts activities that respond to the absence of tension between <span class="hlt">sister</span> kinetochores. Disassembly of this platform in response to intersister kinetochore tension signals the bioriented state. Therefore, tension sensing by shugoshin is a central mechanism by which the bioriented state is read. PMID:24939933</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=chess&pg=3&id=EJ939604','ERIC'); return false;" href="http://eric.ed.gov/?q=chess&pg=3&id=EJ939604"><span id="translatedtitle">Does High-Level Intellectual Performance Depend on Practice Alone? Debunking the Polgar <span class="hlt">Sisters</span> Case</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Howard, Robert W.</p> <p>2011-01-01</p> <p>The famous Polgar <span class="hlt">sisters</span> started chess very young, undertook extensive study, and two became grandmasters. This case often is cited as decisive evidence that practice alone is key in development of expertise, that innate talent is unimportant or non-existent, and that almost anyone can become a grandmaster. But on close examination these claims…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677"><span id="translatedtitle">EVIDENCE FOR THE CHROMOSOMAL REPLICONS AS UNITS OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Current hypotheses of <span class="hlt">sister</span> chromatid exchange (SCE) formation postulate that sites of SCE induction are associated with active replicons or replicon clusters. We have applied the FCC-SCD technique to in vivo studies of mouse bone marrow cells that have been treated with cycloph...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/827476','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/827476"><span id="translatedtitle">Los Alamos National Laboratory's <span class="hlt">Sister</span> Laboratory Collaborations on Low and Intermediate Level Radioactive Waste Management</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Newell, D. L.; Sinkule, B. J.; Apt, K. E.</p> <p>2003-02-25</p> <p>The DOE/National Nuclear Security Administration's (NNSA) ''<span class="hlt">Sister</span> Laboratory'' program allows for bilateral technical cooperation in peaceful uses of nuclear energy for developing nations. The program establishes a direct line of communication between U.S. scientists and the nuclear research and scientific communities in participating countries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=bsa&pg=2&id=ED390973','ERIC'); return false;" href="http://eric.ed.gov/?q=bsa&pg=2&id=ED390973"><span id="translatedtitle">Making a Difference. An Impact Study of Big Brothers/Big <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tierney, Joseph P.; And Others</p> <p></p> <p>This report provides reliable evidence that mentoring programs can positively affect young people. The evidence is derived from research conducted at local affiliates of Big Brothers/Big <span class="hlt">Sisters</span> of America (BB/BSA), the oldest, best-known, and arguably most sophisticated of the country's mentoring programs. Public/Private Ventures, Inc. conducted…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1017170','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1017170"><span id="translatedtitle">Two <span class="hlt">sisters</span> with mental retardation, cataract, ataxia, progressive hearing loss, and polyneuropathy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Begeer, J H; Scholte, F A; van Essen, A J</p> <p>1991-01-01</p> <p>Two <span class="hlt">sisters</span> are described with a disorder characterised by mental retardation, congenital cataract, progressive spinocerebellar ataxia, sensorineural deafness, and signs of peripheral neuropathy. Progressive hearing loss, ataxia, and polyneuropathy became evident in the third decade. The differential diagnosis of this syndrome is discussed including the syndromes described by Berman et al and Koletzko et al. PMID:1661780</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED514909.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED514909.pdf"><span id="translatedtitle">Serving, Learning and Mentoring through the Big Brothers Big <span class="hlt">Sisters</span> Program</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Sivukamaran, Thillainatarajan; Holland, Glenda; Clark, Leonard J.</p> <p>2010-01-01</p> <p>This study describes the collaborative partnership between a Big Brothers Big <span class="hlt">Sisters</span> organization, an elementary school and the College of Education at a public university. The partnership utilized a mentoring system consisting of elementary students, college students, elementary teachers and university faculty. Benefits of the various…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED452094.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED452094.pdf"><span id="translatedtitle"><span class="hlt">Sisters</span> in Science: Using Sports as a Vehicle for Science Learning.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.; Richardson, Greer M.; Green, Tina Sloan; Livingston, Beverly</p> <p></p> <p>This paper describes a project for upper elementary and middle school minority girl students called the <span class="hlt">Sisters</span> in Sport Science (SISS). The SISS program addresses the needs of urban girls in gaining access to equal education in science and mathematics by using athletics as a vehicle for learning. The program provides a non-competitive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Teenage+AND+pregnancy&pg=5&id=EJ965819','ERIC'); return false;" href="http://eric.ed.gov/?q=Teenage+AND+pregnancy&pg=5&id=EJ965819"><span id="translatedtitle">Youths' Caretaking of Their Adolescent <span class="hlt">Sisters</span>' Children: Its Costs and Benefits for Youths' Development</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>East, Patricia L.; Weisner, Thomas S.; Reyes, Barbara T.</p> <p>2006-01-01</p> <p>This study examined how time spent caring for a teenage <span class="hlt">sister</span>'s child and experiences in providing care related to youths' young adult outcomes. Latino and African American youths (N = 108) were studied during middle and late adolescence. Results indicated that youths who provided many hours of child care were more stressed and had lower school…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=cancer+AND+terminal&pg=5&id=EJ484723','ERIC'); return false;" href="http://eric.ed.gov/?q=cancer+AND+terminal&pg=5&id=EJ484723"><span id="translatedtitle">Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and <span class="hlt">Sisters</span>, and Nonclinical Controls.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Madan-Swain, Avi; And Others</p> <p>1993-01-01</p> <p>Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and <span class="hlt">sisters</span> (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531','ERIC'); return false;" href="http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531"><span id="translatedtitle">Meanings of Sisterhood and Developmental Disability: Narratives from White Nondisabled <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McGraw, Lori A.; Walker, Alexis J.</p> <p>2007-01-01</p> <p>Integrating thought from critical feminist and disability theorists via a strategic social constructionist perspective, the authors analyzed 10 in-depth qualitative interviews to begin to understand the dialogue between (a) how nondisabled <span class="hlt">sisters</span> understand themselves and their siblings with developmental disabilities and (b) wider systems of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&id=ED530841','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&id=ED530841"><span id="translatedtitle">When the <span class="hlt">Sisters</span> Said Farewell: The Transition of Leadership in Catholic Elementary Schools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Caruso, Michael P., S.J.</p> <p>2012-01-01</p> <p>"When the <span class="hlt">Sisters</span> Said Farewell" tells an important story of the contributions of Catholic elementary schools to the United States by chronicling the experiences and insights of religious women (nuns) who were the last members of their communities to serve in parish elementary schools, and of those lay men and women who were the first to serve in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=7&id=EJ406575','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=7&id=EJ406575"><span id="translatedtitle">Characteristics of Alcoholism among Catholic <span class="hlt">Sisters</span>: Results of a National Survey.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Spiegel, Virginia M.</p> <p>1989-01-01</p> <p>Obtained information on addiction history, intervention and treatment, and family and community patterns from 221 Catholic <span class="hlt">Sisters</span> in residential treatment for alcoholism. Findings suggest that, although respondents were similar to other women in their vulnerability to addiction, they carried added burdens because of societal expectations of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=6&id=EJ1078896','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=6&id=EJ1078896"><span id="translatedtitle">Teaching <span class="hlt">Sisters</span> and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Raftery, Deirdre</p> <p>2015-01-01</p> <p>This article examines the management of the education enterprise of teaching <span class="hlt">Sisters</span>, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=new&pg=6&id=EJ1048143','ERIC'); return false;" href="http://eric.ed.gov/?q=new&pg=6&id=EJ1048143"><span id="translatedtitle">They Came with a Purpose: Educational Journeys of Nineteenth-Century Irish Dominican <span class="hlt">Sister</span> Teachers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Collins, Jenny</p> <p>2015-01-01</p> <p>Irish Catholic teaching <span class="hlt">sisters</span> were major actors in the development of education systems in New World countries such as the United States, Canada, South Africa, Australia and New Zealand. Immigrants themselves, they faced a number of key challenges as they sought to adapt Old World cultural and educational ideas to the education of the immigrant…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=neuroscience+AND+music&pg=2&id=EJ1003992','ERIC'); return false;" href="http://eric.ed.gov/?q=neuroscience+AND+music&pg=2&id=EJ1003992"><span id="translatedtitle">Empirical Psycho-Aesthetics and Her <span class="hlt">Sisters</span>: Substantive and Methodological Issues--Part II</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Konecni, Vladimir J.</p> <p>2013-01-01</p> <p>Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "<span class="hlt">sister</span>" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=strength+AND+of+AND+materials&pg=3&id=EJ972941','ERIC'); return false;" href="http://eric.ed.gov/?q=strength+AND+of+AND+materials&pg=3&id=EJ972941"><span id="translatedtitle">Addiction to near <span class="hlt">Death</span> in Adolescence</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shaw, Janet</p> <p>2012-01-01</p> <p>This paper takes Betty Joseph's concept of "addiction to near <span class="hlt">death</span>," which describes a clinical situation in which sadism and masochism dominate the relationships of a particular group of patients, and applies it specifically to the case material of a girl in adolescent psychotherapy treatment. A <span class="hlt">link</span> is made between the patient's retreat from…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3589284','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3589284"><span id="translatedtitle">TRPM7, the cytoskeleton and neuronal <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Asrar, Suhail; Aarts, Michelle</p> <p>2013-01-01</p> <p>Ischemic stroke is one of the leading causes of disability and <span class="hlt">death</span> in the world. Elucidation of the underlying mechanisms associated with neuronal <span class="hlt">death</span> during this detrimental process has been of significant interest in the field of research. One principle component vital to the maintenance of cellular integrity is the cytoskeleton. Studies suggest that abnormalities at the level of this fundamental structure are directly <span class="hlt">linked</span> to adverse effects on cellular well-being, including cell <span class="hlt">death</span>. In recent years, evidence has also emerged regarding an imperative role for the transient receptor potential (TRP) family member TRPM7 in the mediation of excitotoxic-independent neuronal demise. In this review, we will elaborate on the current knowledge and unique properties associated with the functioning of this structure. In addition, we will deliberate the involvement of distinct mechanistic pathways during TRPM7-dependent cell <span class="hlt">death</span>, including modifications at the level of the cytoskeleton. PMID:23247582</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_11");'>11</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li class="active"><span>13</span></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_13 --> <div id="page_14" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="261"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Thanatology&pg=2&id=ED200878','ERIC'); return false;" href="http://eric.ed.gov/?q=Thanatology&pg=2&id=ED200878"><span id="translatedtitle">The Effects of <span class="hlt">Death</span> Education.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Freitag, Carl B.; Hassler, Shawn David</p> <p></p> <p>Although fear of <span class="hlt">death</span> is recorded in the writings of the oldest major religions, the study of <span class="hlt">death</span> and the fear of <span class="hlt">death</span> have only occurred for the last few decades. <span class="hlt">Death</span> education courses have grown in number since the early 1970's. College students participated in an investigation of the effects of <span class="hlt">death</span> education on <span class="hlt">death</span> anxiety by…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2009Tecto..28.5015K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2009Tecto..28.5015K"><span id="translatedtitle">Thermal evolution of the <span class="hlt">Sisters</span> shear zone, southern New Zealand; Formation of the Great South Basin and onset of Pacific-Antarctic spreading</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kula, Joseph; Tulloch, Andy J.; Spell, Terry L.; Wells, Michael L.; Zanetti, Kathleen A.</p> <p>2009-10-01</p> <p>The separation of Zealandia from West Antarctica was the final stage in the Cretaceous breakup of the Gondwana Pacific margin. Continental extension resulting in formation of the Great South Basin and thinning of the Campbell Plateau leading to development of the Pacific-Antarctic spreading ridge was partially accommodated along the <span class="hlt">Sisters</span> shear zone. This east-northeast striking brittle-ductile structure exposed along the southeast coast of Stewart Island, New Zealand, is a greenschist facies extensional shear zone that separates a hanging wall of chloritic, brecciated granites, and undeformed conglomerate from a footwall of mylonitic Carboniferous and Early Cretaceous granites. This complex structure exhibits bivergent kinematics and can be subdivided into a northern and southern segment. The 40Ar/39Ar thermochronology indicates that cooling of the shear zone footwall began at ˜94 Ma with accelerated cooling over the interval ˜89-82 Ma. Structural and thermochronological data indicate a spatial and temporal <span class="hlt">link</span> between the <span class="hlt">Sisters</span> shear zone, initial sedimentation within the offshore Great South Basin, extension of the Campbell Plateau, and initiation of the Pacific-Antarctic spreading ridge.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3179045','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3179045"><span id="translatedtitle">MicroRNAs and phylogenomics resolve the relationships of Tardigrada and suggest that velvet worms are the <span class="hlt">sister</span> group of Arthropoda</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Campbell, Lahcen I.; Rota-Stabelli, Omar; Edgecombe, Gregory D.; Marchioro, Trevor; Longhorn, Stuart J.; Telford, Maximilian J.; Philippe, Hervé; Rebecchi, Lorena; Peterson, Kevin J.; Pisani, Davide</p> <p>2011-01-01</p> <p>Morphological data traditionally group Tardigrada (water bears), Onychophora (velvet worms), and Arthropoda (e.g., spiders, insects, and their allies) into a monophyletic group of invertebrates with walking appendages known as the Panarthropoda. However, molecular data generally do not support the inclusion of tardigrades within the Panarthropoda, but instead place them closer to Nematoda (roundworms). Here we present results from the analyses of two independent genomic datasets, expressed sequence tags (ESTs) and microRNAs (miRNAs), which congruently resolve the phylogenetic relationships of Tardigrada. Our EST analyses, based on 49,023 amino acid sites from 255 proteins, significantly support a monophyletic Panarthropoda including Tardigrada and suggest a <span class="hlt">sister</span> group relationship between Arthropoda and Onychophora. Using careful experimental manipulations—comparisons of model fit, signal dissection, and taxonomic pruning—we show that support for a Tardigrada + Nematoda group derives from the phylogenetic artifact of long-branch attraction. Our small RNA libraries fully support our EST results; no miRNAs were found to <span class="hlt">link</span> Tardigrada and Nematoda, whereas all panarthropods were found to share one unique miRNA (miR-276). In addition, Onychophora and Arthropoda were found to share a second miRNA (miR-305). Our study confirms the monophyly of the legged ecdysozoans, shows that past support for a Tardigrada + Nematoda group was due to long-branch attraction, and suggests that the velvet worms are the <span class="hlt">sister</span> group to the arthropods. PMID:21896763</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21896763','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21896763"><span id="translatedtitle">MicroRNAs and phylogenomics resolve the relationships of Tardigrada and suggest that velvet worms are the <span class="hlt">sister</span> group of Arthropoda.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Campbell, Lahcen I; Rota-Stabelli, Omar; Edgecombe, Gregory D; Marchioro, Trevor; Longhorn, Stuart J; Telford, Maximilian J; Philippe, Hervé; Rebecchi, Lorena; Peterson, Kevin J; Pisani, Davide</p> <p>2011-09-20</p> <p>Morphological data traditionally group Tardigrada (water bears), Onychophora (velvet worms), and Arthropoda (e.g., spiders, insects, and their allies) into a monophyletic group of invertebrates with walking appendages known as the Panarthropoda. However, molecular data generally do not support the inclusion of tardigrades within the Panarthropoda, but instead place them closer to Nematoda (roundworms). Here we present results from the analyses of two independent genomic datasets, expressed sequence tags (ESTs) and microRNAs (miRNAs), which congruently resolve the phylogenetic relationships of Tardigrada. Our EST analyses, based on 49,023 amino acid sites from 255 proteins, significantly support a monophyletic Panarthropoda including Tardigrada and suggest a <span class="hlt">sister</span> group relationship between Arthropoda and Onychophora. Using careful experimental manipulations--comparisons of model fit, signal dissection, and taxonomic pruning--we show that support for a Tardigrada + Nematoda group derives from the phylogenetic artifact of long-branch attraction. Our small RNA libraries fully support our EST results; no miRNAs were found to <span class="hlt">link</span> Tardigrada and Nematoda, whereas all panarthropods were found to share one unique miRNA (miR-276). In addition, Onychophora and Arthropoda were found to share a second miRNA (miR-305). Our study confirms the monophyly of the legged ecdysozoans, shows that past support for a Tardigrada + Nematoda group was due to long-branch attraction, and suggests that the velvet worms are the <span class="hlt">sister</span> group to the arthropods. PMID:21896763</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24965436','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24965436"><span id="translatedtitle">Understanding <span class="hlt">death</span> in custody: a case for a comprehensive definition.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ruiz, Géraldine; Wangmo, Tenzin; Mutzenberg, Patrick; Sinclair, Jessica; Elger, Bernice Simone</p> <p>2014-09-01</p> <p>Prisoners sometimes die in prison, either due to natural illness, violence, suicide, or a result of imprisonment. The purpose of this study is to understand <span class="hlt">deaths</span> in custody using qualitative methodology and to argue for a comprehensive definition of <span class="hlt">death</span> in custody that acknowledges <span class="hlt">deaths</span> related to the prison environment. Interviews were conducted with 33 experts, who primarily work as lawyers or forensic doctors with national and/or international organisations. Responses were coded and analysed qualitatively. Defining <span class="hlt">deaths</span> in custody according to the place of <span class="hlt">death</span> was deemed problematic. Experts favoured a dynamic approach emphasising the <span class="hlt">link</span> between the detention environment and occurrence of <span class="hlt">death</span> rather than the actual place of <span class="hlt">death</span>. Causes of <span class="hlt">deaths</span> and different patterns of <span class="hlt">deaths</span> were discussed, indicating that many of these <span class="hlt">deaths</span> are preventable. Lack of an internationally recognised standard definition of <span class="hlt">death</span> in custody is a major concern. Key aspects such as place, time, and causes of <span class="hlt">death</span> as well as relation to the prison environment should be debated and incorporated into the definition. Systematic identification of violence within prison institutions is critical and efforts are needed to prevent unnecessary <span class="hlt">deaths</span> in prison and to protect vulnerable prisoners. PMID:24965436</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/news/fullstory_159060.html','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/news/fullstory_159060.html"><span id="translatedtitle">Global Recession May Have Contributed to Cancer <span class="hlt">Deaths</span></span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... nlm.nih.gov/medlineplus/news/fullstory_159060.html Global Recession May Have Contributed to Cancer <span class="hlt">Deaths</span> Health- ... THURSDAY, May 26, 2016 (HealthDay News) -- The 2008 global economic crisis has been <span class="hlt">linked</span> to a sharp ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20362274','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20362274"><span id="translatedtitle">Severe X-<span class="hlt">linked</span> mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ghezzi, Daniele; Sevrioukova, Irina; Invernizzi, Federica; Lamperti, Costanza; Mora, Marina; D'Adamo, Pio; Novara, Francesca; Zuffardi, Orsetta; Uziel, Graziella; Zeviani, Massimo</p> <p>2010-04-01</p> <p>We investigated two male infant patients who were given a diagnosis of progressive mitochondrial encephalomyopathy on the basis of clinical, biochemical, and morphological features. These patients were born from monozygotic twin <span class="hlt">sisters</span> and unrelated fathers, suggesting an X-<span class="hlt">linked</span> trait. Fibroblasts from both showed reduction of respiratory chain (RC) cIII and cIV, but not of cI activities. We found a disease-segregating mutation in the X-<span class="hlt">linked</span> AIFM1 gene, encoding the Apoptosis-Inducing Factor (AIF) mitochondrion-associated 1 precursor that deletes arginine 201 (R201 del). Under normal conditions, mature AIF is a FAD-dependent NADH oxidase of unknown function and is targeted to the mitochondrial intermembrane space (this form is called AIF(mit)). Upon apoptogenic stimuli, a soluble form (AIF(sol)) is released by proteolytic cleavage and migrates to the nucleus, where it induces "parthanatos," i.e., caspase-independent fragmentation of chromosomal DNA. In vitro, the AIF(R201 del) mutation decreases stability of both AIF(mit) and AIF(sol) and increases the AIF(sol) DNA binding affinity, a prerequisite for nuclear apoptosis. In AIF(R201 del) fibroblasts, staurosporine-induced parthanatos was markedly increased, whereas re-expression of AIF(wt) induced recovery of RC activities. Numerous TUNEL-positive, caspase 3-negative nuclei were visualized in patient #1's muscle, again indicating markedly increased parthanatos in the AIF(R201 del) critical tissues. We conclude that AIF(R201 del) is an unstable mutant variant associated with increased parthanatos-<span class="hlt">linked</span> cell <span class="hlt">death</span>. Our data suggest a role for AIF in RC integrity and mtDNA maintenance, at least in some tissues. Interestingly, riboflavin supplementation was associated with prolonged improvement of patient #1's neurological conditions, as well as correction of RC defects in mutant fibroblasts, suggesting that stabilization of the FAD binding in AIF(mit) is beneficial. PMID:20362274</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4188144','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4188144"><span id="translatedtitle">Brain <span class="hlt">Death</span> and Islam</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ziad-Miller, Amna; Elamin, Elamin M.</p> <p>2014-01-01</p> <p>How one defines <span class="hlt">death</span> may vary. It is important for clinicians to recognize those aspects of a patient’s religious beliefs that may directly influence medical care and how such practices may interface with local laws governing the determination of <span class="hlt">death</span>. Debate continues about the validity and certainty of brain <span class="hlt">death</span> criteria within Islamic traditions. A search of PubMed, Scopus, EMBASE, Web of Science, PsycNet, Sociological Abstracts, DIALOGUE ProQuest, Lexus Nexus, Google, and applicable religious texts was conducted to address the question of whether brain <span class="hlt">death</span> is accepted as true <span class="hlt">death</span> among Islamic scholars and clinicians and to discuss how divergent opinions may affect clinical care. The results of the literature review inform this discussion. Brain <span class="hlt">death</span> has been acknowledged as representing true <span class="hlt">death</span> by many Muslim scholars and medical organizations, including the Islamic Fiqh Academies of the Organization of the Islamic Conference and the Muslim World League, the Islamic Medical Association of North America, and other faith-based medical organizations as well as legal rulings by multiple Islamic nations. However, consensus in the Muslim world is not unanimous, and a sizable minority accepts <span class="hlt">death</span> by cardiopulmonary criteria only. PMID:25287999</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Fulton+AND+Robert&id=EJ161921','ERIC'); return false;" href="http://eric.ed.gov/?q=Fulton+AND+Robert&id=EJ161921"><span id="translatedtitle">The Sociology of <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Fulton, Robert</p> <p>1977-01-01</p> <p>When we start to look at the issues associated with dying and <span class="hlt">death</span>, we must do so in terms of the broadest parameters imaginable. Presented at the Conference on <span class="hlt">Death</span> and Dying: Education, Counseling, and Care, December 1-3, 1976, Orlando, Florida. (Author)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&pg=6&id=EJ923799','ERIC'); return false;" href="http://eric.ed.gov/?q=death&pg=6&id=EJ923799"><span id="translatedtitle"><span class="hlt">Death</span> Acceptance through Ritual</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Reeves, Nancy C.</p> <p>2011-01-01</p> <p>This article summarizes the author's original research, which sought to discover the elements necessary for using <span class="hlt">death</span>-related ritual as a psychotherapeutic technique for grieving people who experience their grief as "stuck," "unending," "maladaptive," and so on. A "<span class="hlt">death</span>-related ritual" is defined as a ceremony, directly involving at least 1…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&pg=5&id=EJ936886','ERIC'); return false;" href="http://eric.ed.gov/?q=death&pg=5&id=EJ936886"><span id="translatedtitle">Conflicting Thoughts about <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Harris, Paul L.</p> <p>2011-01-01</p> <p>Most research on children's conception of <span class="hlt">death</span> has probed their understanding of its biological aspects: its inevitability, irreversibility and terminal impact. Yet many adults subscribe to a religious conception implying that <span class="hlt">death</span> marks the beginning of a new life. Two recent empirical studies confirm that in the course of development, children…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death+AND+grips&id=EJ153201','ERIC'); return false;" href="http://eric.ed.gov/?q=death+AND+grips&id=EJ153201"><span id="translatedtitle">Reflections on <span class="hlt">Death</span> Education</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Riskey, Raymond J.</p> <p>1977-01-01</p> <p>The author comments on the need to discuss <span class="hlt">death</span> openly in the classroom, noting that engaging students with the idea of coming to grips with the fact of their own <span class="hlt">death</span> can prepare them for living, working, and loving more fully. (SH)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Children+AND+death&pg=2&id=EJ942048','ERIC'); return false;" href="http://eric.ed.gov/?q=Children+AND+death&pg=2&id=EJ942048"><span id="translatedtitle">Education for <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Puolimatka, Tapio; Solasaari, Ulla</p> <p>2006-01-01</p> <p><span class="hlt">Death</span> is an unavoidable fact of human life, which cannot be totally ignored in education. Children reflect on <span class="hlt">death</span> and raise questions that deserve serious answers. If an educator completely evades the issue, children will seek other conversation partners. It is possible to find arguments both from secular and religious sources, which alleviate…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1439384','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1439384"><span id="translatedtitle">Mozart's illnesses and <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Davies, P J</p> <p>1983-01-01</p> <p>Throughout his life Mozart suffered frequent attacks of tonsillitis. In 1784 he developed post-streptococcal Schönlein-Henoch syndrome which caused chronic glomerular nephritis and chronic renal failure. His fatal illness was due to Schönlein-Henoch purpura, with <span class="hlt">death</span> from cerebral haemorrhage and bronchopneumonia. Venesection(s) may have contributed to his <span class="hlt">death</span>. PMID:6352940</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/373873','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/373873"><span id="translatedtitle">Programmed cell <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>1995-12-31</p> <p>The purpose of this conference to provide a multidisciplinary forum for exchange of state-of-the-art information on the role programmed cell <span class="hlt">death</span> plays in normal development and homeostasis of many organisms. This volume contains abstracts of papers in the following areas: invertebrate development; immunology/neurology; bcl-2 family; biochemistry; programmed cell <span class="hlt">death</span> in viruses; oncogenesis; vertebrate development; and diseases.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=syria&pg=3&id=EJ729503','ERIC'); return false;" href="http://eric.ed.gov/?q=syria&pg=3&id=EJ729503"><span id="translatedtitle"><span class="hlt">Death</span> Obsession in Palestinians</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Abdel-Khalek, Ahmed M.; Al-Arja, Nahida S.; Abdalla, Taysir</p> <p>2006-01-01</p> <p>The authors explored <span class="hlt">death</span> obsession level and correlates among a sample (N=601) of Palestinians living in the city of Beit Jala, the village of Al-Khader, and the Aida refugee camp in the Bethlehem area. They live in war conditions; the houses of half of them have been demolished. The <span class="hlt">Death</span> Obsession Scale (DOS) was administered. Its alpha…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26595302','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26595302"><span id="translatedtitle">SUICIDE ON <span class="hlt">DEATH</span> ROW.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tartaro, Christine; Lester, David</p> <p>2015-12-01</p> <p>For the period 1976-2011, the suicide rate on <span class="hlt">death</span> rows in the United States was only weakly (and non-significantly) associated with the marriage, birth, divorce, and unemployment rates in the general population. Possible explanations for why social indicators in the larger society might be associated with the behavior of prisoners on <span class="hlt">death</span> row were discussed. PMID:26595302</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Thanatology&id=EJ692045','ERIC'); return false;" href="http://eric.ed.gov/?q=Thanatology&id=EJ692045"><span id="translatedtitle"><span class="hlt">Death</span> Writ Large</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kastenbaum, Robert</p> <p>2004-01-01</p> <p>Mainstream thanatology has devoted its efforts to improving the understanding, care, and social integration of people who are confronted with life-threatening illness or bereavement. This article suggests that it might now be time to expand the scope and mission to include large-scale <span class="hlt">death</span> and <span class="hlt">death</span> that occurs through complex and multi-domain…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1295660','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1295660"><span id="translatedtitle">Near-<span class="hlt">death</span> experiences.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Blackmore, S J</p> <p>1996-01-01</p> <p>Reactions to claims of near-<span class="hlt">death</span> experiences (NDE) range from the popular view that this must be evidence for life after <span class="hlt">death</span>, to outright rejection of the experiences as, at best, drug induced hallucinations or, at worse, pure invention. Twenty years, and much research, later, it is clear that neither extreme is correct. PMID:8683504</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4080519','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4080519"><span id="translatedtitle">CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Harlid, Sophia; Xu, Zongli; Panduri, Vijayalakshmi; Sandler, Dale P.</p> <p>2014-01-01</p> <p>Background: Smoking increases the risk of many diseases, and it is also <span class="hlt">linked</span> to blood DNA methylation changes that may be important in disease etiology. Objectives: We sought to identify novel CpG sites associated with cigarette smoking. Methods: We used two epigenome-wide data sets from the <span class="hlt">Sister</span> Study to identify and confirm CpG sites associated with smoking. One included 908 women with methylation measurements at 27,578 CpG sites using the HumanMethylation27 BeadChip; the other included 200 women with methylation measurements for 473,844 CpG sites using the HumanMethylation450 BeadChip. Significant CpGs from the second data set that were not included in the 27K assay were validated by pyrosequencing in a subset of 476 samples from the first data set. Results: Our study successfully confirmed smoking associations for 9 previously established CpGs and identified 2 potentially novel CpGs: cg26764244 in GNG12 (p = 9.0 × 10–10) and cg22335340 in PTPN6 (p = 2.9 × 10–05). We also found strong evidence of an association between smoking status and cg02657160 in CPOX (p = 7.3 × 10–7), which has not been previously reported. All 12 CpGs were undermethylated in current smokers and showed an increasing percentage of methylation in former and never-smokers. Conclusions: We identified 2 potentially novel smoking related CpG sites, and provided independent replication of 10 previously reported CpGs sites related to smoking, one of which is situated in the gene CPOX. The corresponding enzyme is involved in heme biosynthesis, and smoking is known to increase heme production. Our study extends the evidence base for smoking-related changes in DNA methylation. Citation: Harlid S, Xu Z, Panduri V, Sandler DP, Taylor JA. 2014. CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the <span class="hlt">Sister</span> Study. Environ Health Perspect 122:673–678; http://dx.doi.org/10.1289/ehp.1307480 PMID:24704585</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_12");'>12</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li class="active"><span>14</span></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_14 --> <div id="page_15" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="281"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1375910','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1375910"><span id="translatedtitle"><span class="hlt">Death</span> in Denmark.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Evans, M</p> <p>1990-01-01</p> <p>Does it matter that the hearts of 'brainstem dead' patients may persist in beating spontaneously? Hostile reactions, to the Danish inclusion of cardiac criteria in the determination of <span class="hlt">death</span>, betray reductionist views of human life at the core of 'brainstem' conceptions of <span class="hlt">death</span>. Such views (whether centred on neurological function or on abstractions concerning 'personhood') supplant the richness of human life and <span class="hlt">death</span> with the poverty of essentialism: and mask the lethal nature of beating-heart organ retrieval. The affirmation of cardiac criteria for <span class="hlt">death</span> is not an alternative form of essentialism as some critics suppose, but part of an understanding of human life and <span class="hlt">death</span> which rejects essentialism altogether. The spontaneously persistent heartbeat does not constitute human life, but most certainly counts for it. PMID:2287015</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16309949','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16309949"><span id="translatedtitle">Evaluation of genotoxic effects of Apitol (cymiazole hydrochloride) in vitro by measurement of <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stanimirovic, Zoran; Stevanovic, Jevrosima; Jovanovic, Slobodan; Andjelkovic, Marko</p> <p>2005-12-30</p> <p>Apitol, with cymiazole hydrochloride as the active ingredient, is used in bee-keeping against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes. <span class="hlt">Sister</span> chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35+/-0.18%, 8.31+/-0.20% and 12.33+/-0.25%, respectively), the proliferative index (PI = 1.83+/-0.01, 1.84+/-0.01 and 1.88+/-0.02, respectively) and the frequency of <span class="hlt">sister</span> chromatid exchange (SCE = 8.19+/-1.81, 8.78+/-1.80 and 13.46+/-1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential. PMID:16309949</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19041959','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19041959"><span id="translatedtitle">Very early premature ovarian failure in two <span class="hlt">sisters</span> compound heterozygous for the FMR1 premutation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Van Esch, Hilde; Buekenhout, Luc; Race, Valerie; Matthijs, Gert</p> <p>2009-01-01</p> <p>Expansion of the CGG trinucleotide repeat in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene within the premutation range is one of the known genetic factors associated with premature ovarian failure and earlier age at menopause. Studies have shown that approximately 16-26% of female carriers will develop premature ovarian failure, and current research is focussed on the identification of molecular factors that predict its occurrence in female carriers. In this report we present two <span class="hlt">sisters</span> who are compound heterozygous for a premutation, and who were referred because of very early menopause, occurring at the age of 17 years in the youngest <span class="hlt">sister</span>. Premature ovarian failure associated with FMR1 premutation at such an early age has not been reported in the literature before. PMID:19041959</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22937155','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22937155"><span id="translatedtitle">The first record of a trans-oceanic <span class="hlt">sister</span>-group relationship between obligate vertebrate troglobites.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chakrabarty, Prosanta; Davis, Matthew P; Sparks, John S</p> <p>2012-01-01</p> <p>We show using the most complete phylogeny of one of the most species-rich orders of vertebrates (Gobiiformes), and calibrations from the rich fossil record of teleost fishes, that the genus Typhleotris, endemic to subterranean karst habitats in southwestern Madagascar, is the <span class="hlt">sister</span> group to Milyeringa, endemic to similar subterranean systems in northwestern Australia. Both groups are eyeless, and our phylogenetic and biogeographic results show that these obligate cave fishes now found on opposite ends of the Indian Ocean (separated by nearly 7,000 km) are each others closest relatives and owe their origins to the break up of the southern supercontinent, Gondwana, at the end of the Cretaceous period. Trans-oceanic <span class="hlt">sister</span>-group relationships are otherwise unknown between blind, cave-adapted vertebrates and our results provide an extraordinary case of Gondwanan vicariance. PMID:22937155</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24998850','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24998850"><span id="translatedtitle">Polyoma small T antigen triggers cell <span class="hlt">death</span> via mitotic catastrophe.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pores Fernando, A T; Andrabi, S; Cizmecioglu, O; Zhu, C; Livingston, D M; Higgins, J M G; Schaffhausen, B S; Roberts, T M</p> <p>2015-05-01</p> <p>Polyoma small T antigen (PyST), an early gene product of the polyoma virus, has been shown to cause cell <span class="hlt">death</span> in a number of mammalian cells in a protein phosphatase 2A (PP2A)-dependent manner. In the current study, using a cell line featuring regulated expression of PyST, we found that PyST arrests cells in mitosis. Live-cell and immunofluorescence studies showed that the majority of the PyST expressing cells were arrested in prometaphase with almost no cells progressing beyond metaphase. These cells exhibited defects in chromosomal congression, <span class="hlt">sister</span> chromatid cohesion and spindle positioning, thereby resulting in the activation of the spindle assembly checkpoint. Prolonged mitotic arrest then led to cell <span class="hlt">death</span> via mitotic catastrophe. Cell cycle inhibitors that block cells in G1/S prevented PyST-induced <span class="hlt">death</span>. PyST-induced cell <span class="hlt">death</span> that occurs during M is not dependent on p53 status. These data suggested, and our results confirmed, that PP2A inhibition could be used to preferentially kill cancer cells with p53 mutations that proliferate normally in the presence of cell cycle inhibitors. PMID:24998850</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6885703','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6885703"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchange analysis to monitor genotoxic chemicals. (Latest citations from Pollution Abstracts). Published Search</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1993-03-01</p> <p>The bibliography contains citations concerning the use of the <span class="hlt">sister</span> chromatid exchange (SCE) analysis for toxicological studies. SCE analysis are very sensitive measures of genotoxic damage to chromosomes. SCE toxicological studies analyzing ionizing radiation, chromium compounds, styrene, paint thinner, mercury, cigarette smoke, coal dust, fuel oil, insecticides, ethylene oxide, diesel exhaust, and polychlorinated biphenyls are discussed. SCE studies using both human and animal tissue cultures are described. (Contains a minimum of 191 citations and includes a subject term index and title list.)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2670183','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2670183"><span id="translatedtitle">Characterization of the components of the putative mammalian <span class="hlt">sister</span> chromatid cohesion complex</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Darwiche, N.; Freeman, L.A.; Strunnikov, A.</p> <p>2009-01-01</p> <p>Establishing and maintaining proper <span class="hlt">sister</span> chromatid cohesion throughout the cell cycle are essential for maintaining genome integrity. To understand how <span class="hlt">sister</span> chromatid cohesion occurs in mammals, we have cloned and characterized mouse orthologs of proteins known to be involved in <span class="hlt">sister</span> chromatid cohesion in other organisms. The cDNAs for the mouse orthologs of SMC1S.c. and SMC3S.c., mSMCB and mSMCD respectively, were cloned and the corresponding transcripts and proteins were characterized. mSMCB and mSMCD are transcribed at similar levels in adult mouse tissues except in testis, which has an excess of mSMCD transcripts. The mSMCB and mSMCD proteins, as well as the PW29 protein, a mouse homolog of Mcd1pS.c./Rad21S.p., form a complex similar to cohesin in X. laevis. mSMCB, mSMCD and PW29 protein levels show no significant cell-cycle dependence. The bulk of the mSMCB, mSMCD and PW29 proteins undergo redistribution from the chromosome vicinity to the cytoplasm during prometaphase and back to the chromatin in telophase. This pattern of intracellular localization suggests a complex role for this group of SMC proteins in chromosome dynamics. The PW29 protein and PCNA, which have both been implicated in <span class="hlt">sister</span> chromatid cohesion, do not colocalize, indicating that these proteins may not function in the same cohesion pathway. Overexpression of a PW29-GFP fusion protein in mouse fibroblasts leads to inhibition of proliferation, implicating this protein and its complex with SMC proteins in the control of mitotic cycle progression. PMID:10375619</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15451707','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15451707"><span id="translatedtitle">The queer sensitive interveners in the Little <span class="hlt">Sisters</span> case: a response to Dr. Kendall.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Busby, Karen</p> <p>2004-01-01</p> <p>Three queer sensitive organizations intervened before the Supreme Court of Canada in Little <span class="hlt">Sisters</span> v. Canada, a case that challenged whether and how Canada Customs treated cross border shipments to a gay and lesbian bookstore. This paper reviews the queer sensitive organizations' arguments on some of the issues in the case, especially the scope of obscenity law, and challenges misconceptions about their positions, including those presented in Dr. Kendall's paper (appearing in this volume). PMID:15451707</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279660','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279660"><span id="translatedtitle">Unusual sudden <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Warren, J. V.</p> <p>1985-01-01</p> <p>In contrast to usual sudden <span class="hlt">death</span> seen in the course of coronary artery disease, individuals dying suddenly from other causes form a complex array of situations. In some the causes are readily identifiable. No simple pattern is available to identify the potential candidate, but on review of the many causes some moves by the physician may be helpful. For example, a more complete physical evaluation of young individuals participating in competitive athletics is in order. This is particularly true if the athlete reports an episode of unexplained syncope. This may well be the warning of a propensity towards sudden <span class="hlt">death</span> under physical and emotional stress. Knowledge of the specific problems in underwater swimming and diving, in high altitude exposure and in various circumstances such as certain weight reduction diets and industrial exposures may lead to control of some types of unusual sudden <span class="hlt">death</span>. Clearly, more studies are needed to give answers in so called crib <span class="hlt">death</span>. As the incidence of usual sudden <span class="hlt">death</span> falls, these unusual forms of sudden <span class="hlt">death</span> will represent a more important fraction of sudden <span class="hlt">death</span> in general. PMID:6537674</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749"><span id="translatedtitle"><span class="hlt">Sister</span> kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zielinska, Agata P; Holubcova, Zuzana; Blayney, Martyn; Elder, Kay; Schuh, Melina</p> <p>2015-01-01</p> <p>Aneuploidy in human eggs is the leading cause of pregnancy loss and Down’s syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. Here, we show that many <span class="hlt">sister</span> kinetochores in human oocytes are separated and do not behave as a single functional unit during the first meiotic division. Having separated <span class="hlt">sister</span> kinetochores allowed bivalents to rotate by 90 degrees on the spindle and increased the risk of merotelic kinetochore-microtubule attachments. Advanced maternal age led to an increase in <span class="hlt">sister</span> kinetochore separation, rotated bivalents and merotelic attachments. Chromosome arm cohesion was weakened, and the fraction of bivalents that precociously dissociated into univalents was increased. Together, our data reveal multiple age-related changes in chromosome architecture that could explain why oocyte aneuploidy increases with advanced maternal age. DOI: http://dx.doi.org/10.7554/eLife.11389.001 PMID:26670547</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23590349','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23590349"><span id="translatedtitle">Brother-<span class="hlt">sister</span> incest: data from anonymous computer-assisted self interviews.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stroebel, Sandra S; O'Keefe, Stephen L; Beard, Keith W; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter</p> <p>2013-01-01</p> <p>Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-<span class="hlt">sister</span> incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The other 1,230 served as controls. The victims of brother-<span class="hlt">sister</span> incest had significantly more problematic outcomes than controls on many measures (e.g., more likely than the controls to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). However, victims of brother-<span class="hlt">sister</span> incest also had significantly less problematic outcomes than victims of father-daughter incest on some measures (e.g., significantly less likely than the father-daughter incest victims to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). PMID:23590349</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1717785','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1717785"><span id="translatedtitle">Unnatural sudden infant <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Meadow, R.</p> <p>1999-01-01</p> <p>AIM—To identify features to help paediatricians differentiate between natural and unnatural infant <span class="hlt">deaths</span>.
METHOD—Clinical features of 81 children judged by criminal and family courts to have been killed by their parents were studied. Health and social service records, court documents, and records from meetings with parents, relatives, and social workers were studied.
RESULTS—Initially, 42 children had been certified as dying from sudden infant <span class="hlt">death</span> syndrome (SIDS), and 29 were given another cause of natural <span class="hlt">death</span>. In 24 families, more than one child died; 58died before the age of 6 months and most died in the afternoon or evening. Seventy per cent had experienced unexplained illnesses; over half were admitted to hospital within the previous month, and 15 had been discharged within 24 hours of <span class="hlt">death</span>. The mother, father, or both were responsible for <span class="hlt">death</span> in 43, five, and two families, respectively. Most homes were disadvantaged—no regular income, receiving income support—and mothers smoked. Half the perpetrators had a history of somatising or factitious disorder. <span class="hlt">Death</span> was usually by smothering and 43% of children had bruises, petechiae, or blood on the face.
CONCLUSIONS—Although certain features are indicative of unnatural infant <span class="hlt">death</span>, some are also associated with SIDS. Despite the recent reduction in numbers of infants dying suddenly, inadequacies in the assessment of their <span class="hlt">deaths</span> exist. Until a thorough postmortem examination is combined with evaluation of the history and circumstances of <span class="hlt">death</span> by an experienced paediatrician, most cases of covert fatal abuse will go undetected. The term SIDS requires revision or abandonment.

 PMID:10325752</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6596678','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6596678"><span id="translatedtitle">Manifestations of X-<span class="hlt">linked</span> congenital stationary night blindness in three daughters of an affected male: Demonstration of homozygosity</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Bech-Hansen, N.T. Univ. of Calgary, Alberta ); Pearce, W.G. )</p> <p>1993-01-01</p> <p>X-<span class="hlt">linked</span> congenital stationary night blindness (CSNB1) is a hereditary retinal disorder in which clinical features in affected males usually include myopia, nystagmus, and impaired visual acuity. Electroretinography demonstrates a marked reduction in b-wave amplitude. In the study of a large Mennonite family with CSNB1, three of five <span class="hlt">sisters</span> in one sibship were found to have manifestations of CSNB1. All the sons of these three <span class="hlt">sisters</span> were affected. Each of the two nonmanifesting <span class="hlt">sisters</span> had at least one unaffected son. Analysis of Xp markers in the region Xp21.1-Xp11.22 showed that the two <span class="hlt">sisters</span> who were unaffected had inherited the same maternal X chromosome (i.e., M2). Two of the daughters who manifested with CSNB had inherited the other maternal X chromosome (M1). The third manifesting <span class="hlt">sister</span> inherited a recombinant X chromosome with a crossover between TIMP and DXS255, which suggests that the CSNB1 locus lies proximal to TIMP. One of the affected daughters' sons had inherited the maternal M1 X chromosome, a finding consistent with that chromosome carrying a mutant CSNB gene; the other affected sons inherited the grandfather's X chromosome (i.e., P). Molecular analysis of DNA from three <span class="hlt">sisters</span> with manifestations of CSNB is consistent with their being homozygous at the CSNB1 locus and with their mother being a carrier of CSNB1. 23 refs., 4 figs., 3 tabs.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262626','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4262626"><span id="translatedtitle">Eaten to <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nelson, Charles; Baehrecke, Eric H.</p> <p>2014-01-01</p> <p>Macro-autophagy (hereafter referred to as autophagy) delivers cytoplasmic material to the lysosome for degradation, and has been implicated in many cellular processes, including stress, infection, survival, and <span class="hlt">death</span>. While the regulation and role that autophagy plays in stress, infection, and survival is apparent, the regulation of and role that autophagy has during cell <span class="hlt">death</span> remains relatively unclear. In this review, we highlight what is known about the role that autophagy can play during physiological cell <span class="hlt">death</span>, and discuss the implications of better understanding cellular destruction that involves autophagy. PMID:25323556</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Children+AND+death&pg=6&id=EJ221183','ERIC'); return false;" href="http://eric.ed.gov/?q=Children+AND+death&pg=6&id=EJ221183"><span id="translatedtitle">Children's <span class="hlt">Death</span> Concepts and Ethnicity.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Wass, Hannelore; Towry, Betty J.</p> <p>1980-01-01</p> <p>Relationships between <span class="hlt">death</span> concepts of Black and White children and their racial status were examined. Lower-middle-class elementary children completed a four-item questionnaire on <span class="hlt">death</span>. Most children defined <span class="hlt">death</span> as the end of living and listed physical causes as the explanation of <span class="hlt">death</span>. In general, children's <span class="hlt">death</span> concepts were similar.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Moraines&pg=2&id=EJ124667','ERIC'); return false;" href="http://eric.ed.gov/?q=Moraines&pg=2&id=EJ124667"><span id="translatedtitle">Community <span class="hlt">Links</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Nelson, Mary</p> <p>1975-01-01</p> <p>At Moraine Valley Community College (Illinois), a chain of events, programs, activities, and services has <span class="hlt">linked</span> the college and community in such areas as fine arts, ethnic groups, public services, community action, community service, and community education. (Author/NHM)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=77065503&CFTOKEN=74361355','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=77065503&CFTOKEN=74361355"><span id="translatedtitle">INDUCTION, ACCUMULATION, AND PERSISTENCE OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>The induction, stimulation, and persistence of <span class="hlt">sister</span> chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2010dmak.book..355D','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2010dmak.book..355D"><span id="translatedtitle"><span class="hlt">Link</span> Analysis</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Donoho, Steve</p> <p></p> <p><span class="hlt">Link</span> analysis is a collection of techniques that operate on data that can be represented as nodes and <span class="hlt">links</span>. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004AGUFM.T33A1327T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004AGUFM.T33A1327T"><span id="translatedtitle">Finite strain and relative rheology from field exposures of mantle peridotite, Twin <span class="hlt">Sisters</span>, Washington</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tikoff, B.; Larson, C. E.; Newman, J.; Little, T.</p> <p>2004-12-01</p> <p>We present estimates of finite strain and relative rheology of naturally deformed mantle materials based on field observations in the Twin <span class="hlt">Sisters</span> Range of Washington state. The Twin <span class="hlt">Sisters</span> ultramafic body is a 16 by 5.5 km body located 30 km east of Bellingham, Washington. The outcrops show virtually no serpentinization away from the metamorphic sole. We conducted detailed structural mapping in a 100 by 150 meter field area located east of the crest of the Twin <span class="hlt">Sisters</span> range and approximately midway between the north and south ends. The foliation strikes ~155 and the lineation pitches 40 S. Folded orthopyroxenite dikes within the host dunite allow us to characterize the finite strain. Dikes trending NE-SE were folded, while dikes trending NW-SE were elongated or boudinaged. Using the method of Talbot (1970), the principal stretch directions in the horizontal plane were calculated using the deformed dikes. We calculated a maximum stretch of 1.596 oriented at 151 (similar to the trace of the foliation) and a minimum stretch of 0.286 in direction 061. Assuming that the lineation and foliation represent the orientation of S1 and the S1S2 plane, respectively, a finite strain ellipsoid was determined. The best fitting answer defines an oblate ellipsoid with S1=3.15, S2=1.11, and S3=0.286. Thus, on this outcrop, the Twin <span class="hlt">Sisters</span> dunite has an oblate-shaped finite strain ellipsoid whose long axis plunges 40 to the SE. The same area provides constraints on relative rheology. Folded orthopyroxenite dikes show a linear relationship between fold wavelength and dike thickness, indicating that they initiated as buckle folds. Using dynamic instability analysis, the orthopyroxene within the dikes is calculated to have ~31 times the effective viscosity of olivine of the dunite matrix, assuming a power law exponenent of n=3 (dislocation creep) for both the dikes and the matrix. Although not investigated in detail, similar orientations of fabrics are observed throughout the Twin</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://kidshealth.org/en/teens/someone-died.html','NIH-MEDLINEPLUS'); return false;" href="http://kidshealth.org/en/teens/someone-died.html"><span id="translatedtitle"><span class="hlt">Death</span> and Grief</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... for Parents for Kids for Teens Teens Home Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Q& ... a <span class="hlt">death</span> or loss. Grief can affect our body, mind, emotions, and spirit. People might notice or show ...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_13");'>13</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li class="active"><span>15</span></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_15 --> <div id="page_16" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="301"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Capital+AND+punishment&pg=3&id=EJ354907','ERIC'); return false;" href="http://eric.ed.gov/?q=Capital+AND+punishment&pg=3&id=EJ354907"><span id="translatedtitle">Eighth Amendment & <span class="hlt">Death</span> Penalty.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shortall, Joseph M.; Merrill, Denise W.</p> <p>1987-01-01</p> <p>Presents a lesson on capital punishment for juveniles based on three hypothetical cases. The goal of the lesson is to have students understand the complexities of decisions regarding the <span class="hlt">death</span> penalty for juveniles. (JDH)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=hitler&pg=3&id=EJ517010','ERIC'); return false;" href="http://eric.ed.gov/?q=hitler&pg=3&id=EJ517010"><span id="translatedtitle">Hitler's <span class="hlt">Death</span> Camps.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Wieser, Paul</p> <p>1995-01-01</p> <p>Presents a high school lesson on Hitler's <span class="hlt">death</span> camps and the widespread policy of brutality and oppression against European Jews. Includes student objectives, instructional procedures, and a chart listing the value of used clothing taken from the Jews. (CFR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669"><span id="translatedtitle">Chl1p, a DNA helicase-like protein in budding yeast, functions in <span class="hlt">sister</span>-chromatid cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skibbens, Robert V</p> <p>2004-01-01</p> <p>From the time of DNA replication until anaphase onset, <span class="hlt">sister</span> chromatids remain tightly paired along their length. Ctf7p/Eco1p is essential to establish <span class="hlt">sister</span>-chromatid pairing during S-phase and associates with DNA replication components. DNA helicases precede the DNA replication fork and thus will first encounter chromatin sites destined for cohesion. In this study, I provide the first evidence that a DNA helicase is required for proper <span class="hlt">sister</span>-chromatid cohesion. Characterizations of chl1 mutant cells reveal that CHL1 interacts genetically with both CTF7/ECO1 and CTF18/CHL12, two genes that function in <span class="hlt">sister</span>-chromatid cohesion. Consistent with genetic interactions, Chl1p physically associates with Ctf7p/Eco1p both in vivo and in vitro. Finally, a functional assay reveals that Chl1p is critical for <span class="hlt">sister</span>-chromatid cohesion. Within the budding yeast genome, Chl1p exhibits the highest degree of sequence similarity to human CHL1 isoforms and BACH1. Previous studies revealed that human CHLR1 exhibits DNA helicase-like activities and that BACH1 is a helicase-like protein that associates with the tumor suppressor BRCA1 to maintain genome integrity. Our findings document a novel role for Chl1p in <span class="hlt">sister</span>-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated. PMID:15020404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4784493','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4784493"><span id="translatedtitle">Funerals against <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Bailey, Tara; Walter, Tony</p> <p>2016-01-01</p> <p>While anthropological studies in non-Western societies show how funerals protect the community from the threat of <span class="hlt">death</span>, sociological studies of British funerals have so far focused on meanings for the private family. The article reports on results from a Mass Observation directive – the first British study to focus specifically on the entire funeral congregation – and shows how attendees experience the contemporary life-centred funeral as a symbolic conquest of <span class="hlt">death</span>. While the eulogy’s accuracy is important, even more so – at least for some – is its authenticity, namely that the speaker has personal knowledge of the deceased. Whereas Davies analyses the power of professionally delivered ritual words against <span class="hlt">death</span>, our data reveals how admired is the courage exercised by non-professionals in speaking against <span class="hlt">death</span>, however faltering their words. Further, the very presence of a congregation whose members have known the deceased in diverse ways embodies a configurational eulogy, which we term relationships against <span class="hlt">death</span>. We thus argue that funerals symbolically conquer <span class="hlt">death</span> not only through words delivered by ritual specialists, but also through those who knew the deceased congregating and speaking. PMID:27019605</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2744427','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2744427"><span id="translatedtitle">Classification of cell <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kroemer, G; Galluzzi, L; Vandenabeele, P; Abrams, J; Alnemri, ES; Baehrecke, EH; Blagosklonny, MV; El-Deiry, WS; Golstein, P; Green, DR; Hengartner, M; Knight, RA; Kumar, S; Lipton, SA; Malorni, W; Nuñez, G; Peter, ME; Tschopp, J; Yuan, J; Piacentini, M; Zhivotovsky, B; Melino, G</p> <p>2009-01-01</p> <p>Different types of cell <span class="hlt">death</span> are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell <span class="hlt">Death</span> (NCCD) proposes unified criteria for the definition of cell <span class="hlt">death</span> and of its different morphologies, while formulating several caveats against the misuse of words and concepts that slow down progress in the area of cell <span class="hlt">death</span> research. Authors, reviewers and editors of scientific periodicals are invited to abandon expressions like ‘percentage apoptosis’ and to replace them with more accurate descriptions of the biochemical and cellular parameters that are actually measured. Moreover, at the present stage, it should be accepted that caspase-independent mechanisms can cooperate with (or substitute for) caspases in the execution of lethal signaling pathways and that ‘autophagic cell death’ is a type of cell <span class="hlt">death</span> occurring together with (but not necessarily by) autophagic vacuolization. This study details the 2009 recommendations of the NCCD on the use of cell <span class="hlt">death</span>-related terminology including ‘entosis’, ‘mitotic catastrophe’, ‘necrosis’, ‘necroptosis’ and ‘pyroptosis’. PMID:18846107</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27378572','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27378572"><span id="translatedtitle"><span class="hlt">Deaths</span>: Final Data for 2014.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kochanek, Kenneth D; Murphy, Sherry L; Xu, Jiaquan; Tejada-Vera, Betzaida</p> <p>2016-06-01</p> <p>Objectives-This report presents final 2014 data on U.S. <span class="hlt">deaths</span>, <span class="hlt">death</span> rates, life expectancy, infant mortality, and trends, by selected characteristics such as age, sex, Hispanic origin, race, state of residence, and cause of <span class="hlt">death</span>. PMID:27378572</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3507438','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3507438"><span id="translatedtitle">Sudden <span class="hlt">death</span> in Lesch-Nyhan disease</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Neychev, Vladimir Kostadinov; Jinnah, H A</p> <p>2012-01-01</p> <p>To increase awareness of sudden and unexpected <span class="hlt">death</span> in Lesch-Nyhan disease (LND) and to explore its potential causes, we report the anteceding clinical features and laboratory evaluations of five males with LND who ultimately experienced sudden and unexpected <span class="hlt">death</span>, along with three additional males who suffered serious respiratory events during life. The ages of patients ranged from 2 to 45 years. The cause of sudden <span class="hlt">death</span> in LND appears to have a respiratory rather than a cardiogenic basis. All cases cannot be <span class="hlt">linked</span> readily with a single respiratory process. Instead, different respiratory processes appear to operate in different cases. These may include aspiration, laryngospasm, central apnea, cyanotic breath-holding spells, and high cervical spine damage. Better recognition of these processes will help to guide appropriate workup and management that could include chest imaging, endoscopy of the airways, polysomnography, electroencephalogram, and brain and/or spine imaging. PMID:17044962</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-222.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec725-222.pdf"><span id="translatedtitle">20 CFR 725.222 - Conditions of entitlement; parent, brother, or <span class="hlt">sister</span>.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... disabled due to pneumoconiosis at the time of <span class="hlt">death</span> or to have died due to pneumoconiosis. A surviving... establish that the miner's <span class="hlt">death</span> was due to pneumoconiosis in order to establish entitlement to...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24902504','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24902504"><span id="translatedtitle">Sudden cardiac <span class="hlt">death</span> & the Reverse Dodo Verdict.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Healy, David; Howe, Gareth; Mangin, Derelie; Le Noury, Joanna</p> <p>2014-01-01</p> <p>Adverse effects of treatment on cardiac QT intervals were first reported 50 years ago. A clear <span class="hlt">link</span> to sudden <span class="hlt">death</span> was established, but the problem remained relatively unknown. The issue of treatment related effects on the heart, and the contribution this might make to sudden cardiac <span class="hlt">deaths</span> in general, came more clearly into focus 20 years ago, <span class="hlt">linked</span> to regulatory actions. In an era of polypharmacy, and mixing of prescribed and non-prescribed pharmacologically active agents it is now becoming increasingly clear that unanticipated cardiac effects may be common and a significant cause of mortality. There is likely underreporting and also underdiagnosis, as recognition requires a timely ECG. This paper proposes two methods to handle the problem. PMID:24902504</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=mesa&pg=6&id=EJ566437','ERIC'); return false;" href="http://eric.ed.gov/?q=mesa&pg=6&id=EJ566437"><span id="translatedtitle">Powerful <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenoweth, Karin; Stephens, Angela; Evelyn, Jamilah</p> <p>1998-01-01</p> <p>Five black women presiding over college campuses with over 20,000 students are profiled: Del M. Anderson (City College of San Francisco, CA); Constance M. Carroll (San Diego Mesa College, CA); Ruth Burgos-Sasscer (Houston Community College System, TX); Jerry Sue Thornton (Cuyahoga Community College, OH); and Belle S. Wheelan (Northern Virginia…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4433464','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4433464"><span id="translatedtitle">Brain <span class="hlt">death</span> declaration</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Wahlster, Sarah; Wijdicks, Eelco F.M.; Patel, Pratik V.; Greer, David M.; Hemphill, J. Claude; Carone, Marco</p> <p>2015-01-01</p> <p>Objective: To assess the practices and perceptions of brain <span class="hlt">death</span> determination worldwide and analyze the extent and nature of variations among countries. Methods: An electronic survey was distributed globally to physicians with expertise in neurocritical care, neurology, or related disciplines who would encounter patients at risk of brain <span class="hlt">death</span>. Results: Most countries (n = 91, response rate 76%) reported a legal provision (n = 63, 70%) and an institutional protocol (n = 70, 77%) for brain <span class="hlt">death</span>. Institutional protocols were less common in lower-income countries (2/9 of low [22%], 9/18 lower-middle [50%], 22/26 upper-middle [85%], and 37/38 high-income countries [97%], p < 0.001). Countries with an organized transplant network were more likely to have a brain <span class="hlt">death</span> provision compared with countries without one (53/64 [83%] vs 6/25 [24%], p < 0.001). Among institutions with a formalized brain <span class="hlt">death</span> protocol, marked variability occurred in requisite examination findings (n = 37, 53% of respondents deviated from the American Academy of Neurology criteria), apnea testing, necessity and type of ancillary testing (most commonly required test: EEG [n = 37, 53%]), time to declaration, number and qualifications of physicians present, and criteria in children (distinct pediatric criteria: n = 38, 56%). Conclusions: Substantial differences in perceptions and practices of brain <span class="hlt">death</span> exist worldwide. The identification of discrepancies, improvement of gaps in medical education, and formalization of protocols in lower-income countries provide first pragmatic steps to reconciling these variations. Whether a harmonized, uniform standard for brain <span class="hlt">death</span> worldwide can be achieved remains questionable. PMID:25854866</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23822156','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23822156"><span id="translatedtitle">Applications of social network media in medicolegal <span class="hlt">death</span> investigation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hookano, Ryan; Knight, Laura D; Brunelli, Ronald A; Stoppacher, Robert</p> <p>2013-11-01</p> <p>With the increased popularity of online social networking services (SNS) such as Facebook, <span class="hlt">Linked</span>In, Twitter, and Google+, we propose that a wealth of new resources is available for medicolegal <span class="hlt">death</span> investigation. Recognizing this potential, we identified cases in which social media had been useful in the past in our office and asked our investigative staff to consider using social media in current cases. These cases provided illustrative examples for this primer regarding how information from SNS was used in <span class="hlt">death</span> investigations in our office. Information gleaned from online social media aided in establishing preliminary identification of a decedent, locating next-of-kin, investigating the circumstances of <span class="hlt">death</span> as relevant to the manner of <span class="hlt">death</span>, corroborating eyewitness accounts, and providing information relevant to time of <span class="hlt">death</span>. Potential pitfalls were identified, such as shared accounts or online impostors. SNS proved useful to the medicolegal <span class="hlt">death</span> investigator and medical examiner, so long as their limitations were recognized. PMID:23822156</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15797838','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15797838"><span id="translatedtitle">Expanding roles of programmed cell <span class="hlt">death</span> in mammalian neurodevelopment.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>De Zio, Daniela; Giunta, Luigi; Corvaro, Marco; Ferraro, Elisabetta; Cecconi, Francesco</p> <p>2005-04-01</p> <p>Programmed cell <span class="hlt">death</span> is an orchestrated form of cell <span class="hlt">death</span> in which cells are actively involved in their own demise. During neural development in mammals, many progenitor cells, immature cells or differentiated cells undergo the most clearly characterized type of cell <span class="hlt">death</span>, apoptosis. Several pathways of apoptosis have been <span class="hlt">linked</span> to neural development, but according to the numerous and striking phenotypes observed when apoptotic genes are inactivated, the mitochondrial <span class="hlt">death</span>-route is the most important pathway in this context. Here, we discuss the relative importance of pro-growth/pro-<span class="hlt">death</span> factors in the control of neural tissue development. We also discuss the impact of studying programmed cell <span class="hlt">death</span> in development in order to better understand the basis of several human diseases and embryonic defects of the nervous system. PMID:15797838</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Thanatology&pg=2&id=EJ191396','ERIC'); return false;" href="http://eric.ed.gov/?q=Thanatology&pg=2&id=EJ191396"><span id="translatedtitle">Perspectives on <span class="hlt">Death</span>: An Experiential Course on <span class="hlt">Death</span> Education.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Stefan, Edwin S.</p> <p>1978-01-01</p> <p>Describes and evaluates a college psychology course on <span class="hlt">death</span> education (thanatology). Course objectives were to help students become aware of the feelings involved in facing <span class="hlt">death</span>, encourage discussion on the subject of <span class="hlt">death</span>, motivate students to change their attitudes about <span class="hlt">death</span>, and encourage practical planning for funeral arrangements.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Thanatology&id=EJ231704','ERIC'); return false;" href="http://eric.ed.gov/?q=Thanatology&id=EJ231704"><span id="translatedtitle"><span class="hlt">Death</span> Threat and <span class="hlt">Death</span> Concerns in the College Student.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tobacyk, Jerome; Eckstein, Daniel</p> <p>1980-01-01</p> <p>Thanatology students reported significantly lesser <span class="hlt">death</span> threat and significantly greater <span class="hlt">death</span> concerns. Trait anxiety was found to be a significant predictor of change in <span class="hlt">death</span> threat in the Thanatology Group, with lesser anxiety associated with greater decline in <span class="hlt">death</span> threat. (Author)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=linked+AND+open+AND+data&pg=6&id=ED314045','ERIC'); return false;" href="http://eric.ed.gov/?q=linked+AND+open+AND+data&pg=6&id=ED314045"><span id="translatedtitle"><span class="hlt">Linked</span> Systems.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Association of Research Libraries, Washington, DC.</p> <p></p> <p>Three papers are compiled here for research library directors: (1) "Background: Open Systems Interconnection," in which David F. Bishop provides fundamental background information to explain the concept of the emerging technology of <span class="hlt">linked</span> systems and open systems interconnection--i.e., an agreed upon standard set of conventions or rules that,…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26771079','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26771079"><span id="translatedtitle">Sexual dimorphism in <span class="hlt">sister</span> species of Leucoraja skate and its relationship to reproductive strategy and life history.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Martinez, Christopher M; Rohlf, F James; Frisk, Michael G</p> <p>2016-03-01</p> <p>Instances of sexual dimorphism occur in a great variety of forms and manifestations. Most skates (Batoidea: Rajoidei) display some level of body shape dimorphism in which the pectoral fins of mature males develop to create a distinct bell-shaped body not found in females. This particular form of dimorphism is present in each of the <span class="hlt">sister</span> species Leucoraja erinacea and Leucoraja ocellata, but differences between sexes are much greater in the former. In order to understand the nature and potential causes of pectoral dimorphism, we used geometric morphometrics to investigate allometry of fin shape in L. erinacea and L. ocellata and its relationship to the development of reproductive organs, based on previous work on the bonnethead shark, Sphyrna tiburo. We found that allometric trajectories of overall pectoral shape were different in both species of skate, but only L. erinacea varied significantly with respect to endoskeleton development. Male maturation was characterized by a number of sex-specific morphological changes, which appeared concurrently in developmental timing with elongation of cartilage-supported claspers. We suggest that external sexual dimorphism of pectoral fins in skates is a byproduct of skeletal growth needed for clasper development. Further, the magnitude of male shape change appears to be <span class="hlt">linked</span> to the differential life histories of species. This work reports for the first time that pectoral dimorphism is a persistent feature in rajoid fishes, occurring in varying degrees across several genera. Lastly, our results suggest that pectoral morphology may be useful as a relative indicator of reproductive strategy in some species. PMID:26771079</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24343674','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24343674"><span id="translatedtitle">Infant <span class="hlt">deaths</span> in slings.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Madre, Chrystèle; Rambaud, Caroline; Avran, David; Michot, Charlotte; Sachs, Philippe; Dauger, Stéphane</p> <p>2014-12-01</p> <p>Although the incidence of sudden unexpected <span class="hlt">death</span> in infancy (SUDI) decreased markedly after campaigns to promote supine positioning during sleeping, it has remained unchanged over the last decade. Epidemiological data suggest a role for new causes such as suffocation, asphyxia, and entrapment. Health authorities in several countries have issued warnings about slings used to carry infants. However, few reports of infant <span class="hlt">deaths</span> in slings have been published in medical journals. Our paediatric intensive care unit has admitted two infants who experienced cardiorespiratory arrest while carried in a sling. Diagnostic investigations including a post-mortem examination established asphyxia as the mechanism of <span class="hlt">death</span>. In conclusion, baby slings may carry a risk of SUDI, either by compression of the baby into a forward-flexed position or by direct suffocation. European recommendations for the cautious use of baby slings should be disseminated to families and professionals involved in caring for infants, as done recently in Australia, Canada, and the USA. PMID:24343674</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18214069','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18214069"><span id="translatedtitle">The "moment of <span class="hlt">death</span>".</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Valentine, Christine</p> <p>2007-01-01</p> <p>The "moment of <span class="hlt">death</span>," once a dominant concept in preparing for a "good <span class="hlt">death</span>", has been eclipsed by a focus on the wider concept of the "dying trajectory". However, findings from interviews with 25 bereaved individuals suggest that dying loved ones' final moments may still be experienced as highly significant in their own right. In some accounts the dying individual's final moments did not feature or made little impression, either because the survivor was not present, or there was no obviously definable moment, or because other, usually medical factors, such as whether to resuscitate the person, took precedence. However, in six cases such moments were constructed as profound, special, and memorable occasions. These constructions are explored in relation to achieving a good <span class="hlt">death</span>, the dying trajectory as a whole, and making sense of the bereavement experience. Their implications for sociological theories of identity and embodiment are also considered. PMID:18214069</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16645674','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16645674"><span id="translatedtitle">[Sexuality and <span class="hlt">death</span>].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Sapetti, Adrián</p> <p>2006-01-01</p> <p>It is intented to show two apparently antithetic poles: Sexuality and <span class="hlt">Death</span>, in fact interpenetrate themselves, disguising the fear of <span class="hlt">death</span>, or the desire to die, Eros' world. Different expressions of culture are analyzed, especially the one known as The Profane Time, the time for work, which is characterized by the submission to interdicts (prohibitions) and, on the other hand, the Time for Joy or The Sacred Time, characterized by the transgression of such prohibitions. Its relationship with the interdicts'violations in the sexual as well as in the <span class="hlt">death</span> arena is analyzed in order to connect the human being's fear in the presence of the unrestraint, the overflow and the abandonment of the time established for work that would imply free sexuality. The latter is connected with some conclusions that could be considered useful in the field of Sexual Therapies, with a certain critical look at the mechanist settlement applied to those treatments. PMID:16645674</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_14");'>14</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li class="active"><span>16</span></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_16 --> <div id="page_17" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="321"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23883091','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23883091"><span id="translatedtitle">Wolfgang Amadeus Mozart: the <span class="hlt">death</span> of a genius.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hatzinger, Martin; Hatzinger, Jurgen; Sohn, Michael</p> <p>2013-01-01</p> <p>The early and unexpected <span class="hlt">death</span> of Wolfgang Amadeus Mozart (Salzburg, 1756 - Vienna, 1791) was a mystery from the very first day and the subject of wildest speculations and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious <span class="hlt">death</span> of Mozart with increasing intensity. The aim of this article was to recreate Mozart's pathography relying on the his correspondence with father Leopold and <span class="hlt">sister</span> Nannerl and on reports from his physicians and contemporaries. The rumour that Mozart was poisoned followed shortly after his <span class="hlt">death</span> on 5 December 1791, at the age of 35, and has survived to this day. The alleged culprits were his physician van Swieten, Mozart's freemasons lodge, and the Imperial Chapel Master Salieri. Mozart however died of chronic kidney disease and ultimately of uraemia. If kidney damage reaches a critical point, even a minimum additional stress can lead to its failure. This usually occurs in the fourth decade of life. Next time we listen to Mozart, we should remember that this apparently happy person was actually a precocious boy, ripped of his childhood, whose short life was an endless chain of complaints, fatigue, misery, concern, and malady. PMID:23883091</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20503640','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20503640"><span id="translatedtitle">[The <span class="hlt">death</span> of Cleopatra].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guillemain, Bernard</p> <p>2009-01-01</p> <p>The image of a queen bitten by a snake is controversial and the facts, such as the swiftness of her <span class="hlt">death</span> and her servants, and scientific experiments are in favour of a deadly poisoning. The author reminds that in the ancient texts the snake had sacred virtues and it was a symbolic image to embellish the suicide of the one who was sentenced to <span class="hlt">death</span> by the Romans. Octaves set up the myth of a fatal bite which became an iconographic image for the cinema. PMID:20503640</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24294729','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24294729"><span id="translatedtitle">[Near <span class="hlt">death</span> experiences].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rubia Vila, Francisco José</p> <p>2012-01-01</p> <p>Near <span class="hlt">Death</span> Experiences are those accounted by people who after being clinically dead return to life spontaneously or after reanimation. These experiences have been used traditionally to support the belief in the existence of the soul and of life after <span class="hlt">death</span>. However, today neuroscience tries to explain these experiences from the scientific point of view, i.e. explaining them based on their brain substrates. Their resemblance to mystic experiences and to altered states of consciousness seems to indicate that they may be produced by hyperactivity of limbic structures caused by anoxia or hypercapnia. PMID:24294729</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4993918','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4993918"><span id="translatedtitle">Two Cases of Endometrial Cancer in Twin <span class="hlt">Sisters</span> with Myotonic Dystrophy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2016-01-01</p> <p>We describe two cases of endometrial cancer (EC) occurring in nulligravid twin <span class="hlt">sisters</span> with myotonic dystrophy. Both tested negative for Lynch syndrome and both were treated with laparoscopic hysterectomy with bilateral salpingooophorectomy and adjuvant radiotherapy. Although EC tends to run in families, the diagnosis in itself is not considered sufficient cause for screening or prophylactic measures in close relatives. However, the presence of additional risk factors, such as nulligravidity and myotonic dystrophy in the underlying cases, may call for extra vigilance in first-degree family members. PMID:27595026</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2585535','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2585535"><span id="translatedtitle">Genotoxicity evaluation in patients on phenobarbital monotherapy by <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schaumann, B A; Winge, V B; Pederson, M</p> <p>1989-01-01</p> <p>The potential of phenobarbital to interact with DNA has been studied using the <span class="hlt">sister</span> chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls. All patients were otherwise healthy individuals, treated chronically with phenobarbital in monotherapy. No statistically significant differences in SCE levels were found between the patient and control groups. Smoking was associated with increased SCE frequencies. The experiment was repeated with five available patients, using a slightly modified methodology. Although different SCE scores were obtained, the results of both tests were comparable. PMID:2585535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24598400','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24598400"><span id="translatedtitle">Diet transiently improves migraine in two twin <span class="hlt">sisters</span>: possible role of ketogenesis?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Di Lorenzo, Cherubino; Currà, Antonio; Sirianni, Giulio; Coppola, Gianluca; Bracaglia, Martina; Cardillo, Alessandra; De Nardis, Lorenzo; Pierelli, Francesco</p> <p>2013-01-01</p> <p>The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin <span class="hlt">sisters</span>, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine. PMID:24598400</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/254004','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/254004"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchange analysis to monitor genotoxic chemicals. (Latest citations from Pollution abstracts). Published Search</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>1996-04-01</p> <p>The bibliography contains citations concerning the use of the <span class="hlt">sister</span> chromatid exchange (SCE) analysis for toxicological studies. SCE analysis are very sensitive measures of genotoxic damage to chromosomes. SCE toxicological studies analyzing ionizing radiation, chromium compounds, styrene, paint thinner, mercury, cigarette smoke, coal dust, fuel oil, insecticides, ethylene oxide, diesel exhaust, and polychlorinated biphenyls are discussed. SCE studies using both human and animal tissue cultures are described. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25401907','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25401907"><span id="translatedtitle">Dark three-<span class="hlt">sister</span> rogue waves in normally dispersive optical fibers with random birefringence.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chen, Shihua; Soto-Crespo, Jose M; Grelu, Philippe</p> <p>2014-11-01</p> <p>We investigate dark rogue wave dynamics in normally dispersive birefringent optical fibers, based on the exact rational solutions of the coupled nonlinear Schrödinger equations. Analytical solutions are derived up to the second order via a nonrecursive Darboux transformation method. Vector dark "three-<span class="hlt">sister</span>" rogue waves as well as their existence conditions are demonstrated. The robustness against small perturbations is numerically confirmed in spite of the onset of modulational instability, offering the possibility to observe such extreme events in normal optical fibers with random birefringence, or in other Manakov-type vector nonlinear media. PMID:25401907</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1009722','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1009722"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchange analysis in lymphocytes of workers exposed to hexavalent chromium.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nagaya, T; Ishikawa, N; Hata, H</p> <p>1989-01-01</p> <p>To investigate the usefulness of <span class="hlt">sister</span> chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers. These results suggest that SCE analysis in human lymphocytes is not a good indicator of possible mutagenic effects of exposure to hexavalent Cr. PMID:2920143</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26850509','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26850509"><span id="translatedtitle">Pre- and post-natal growth in two <span class="hlt">sisters</span> with 3-M syndrome.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lugli, Licia; Bertucci, Emma; Mazza, Vincenzo; Elmakky, Amira; Ferrari, Fabrizio; Neuhaus, Christine; Percesepe, Antonio</p> <p>2016-04-01</p> <p>3-M syndrome (OMIM #273750) is a rare autosomal recessive growth disorder characterized by severe pre- and post-natal growth restriction, associated with minor skeletal abnormalities and dysmorphisms. Although the 3-M syndrome is well known as a primordial dwarfism, descriptions of the prenatal growth are missing. We report a family with variable phenotypic features of 3-M syndrome and we describe the prenatal and postnatal growth pattern of two affected <span class="hlt">sisters</span> with a novel homozygous CUL7 mutation (c.3173-1G>C), showing a pre- and post-natal growth deficiency and a normal cranial circumference. PMID:26850509</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3951260','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3951260"><span id="translatedtitle">Diet transiently improves migraine in two twin <span class="hlt">sisters</span>: possible role of ketogenesis?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Di Lorenzo, Cherubino; Currà, Antonio; Sirianni, Giulio; Coppola, Gianluca; Bracaglia, Martina; Cardillo, Alessandra; De Nardis, Lorenzo; Pierelli, Francesco</p> <p>2013-01-01</p> <p>Summary The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following low-carbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin <span class="hlt">sisters</span>, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine. PMID:24598400</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26787157','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26787157"><span id="translatedtitle">Mitochondrial Genes Reveal Triatoma jatai as a <span class="hlt">Sister</span> Species to Triatoma costalimai (Reduviidae: Triatominae).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Teves, Simone Caldas; Gardim, Sueli; Carbajal de la Fuente, Ana Laura; Lopes, Catarina Macedo; Gonçalves, Teresa Cristina Monte; dos Santos Mallet, Jacenir Reis; da Rosa, João Aristeu; Almeida, Carlos Eduardo</p> <p>2016-03-01</p> <p>Triatoma jatai was described using a set of morphological structures from specimens collected in Paranã municipality of Tocantins State, Brazil. Under a Bayesian framework and using two mitochondrial genes (16S and COI), phylogenetic analysis recovered T. jatai as a <span class="hlt">sister</span> species to Triatoma costalimai with higher genetic distances than between other well-recognized species. Our results agree with previous suggestions based on morphometric analysis. In the light of the non-monophyly of Matogrossensis subcomplex, the inclusion of T. jatai shall be considered for reevaluating this group. PMID:26787157</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/mf1952','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/mf1952"><span id="translatedtitle">Geologic map of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes, Lane, and Linn counties, Oregon</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Taylor, E.M.; MacLeod, N.S.; Sherrod, D.R.; Walker, G.W.</p> <p>1987-01-01</p> <p>The Wilderness Act (Public Law 88-577, September 3, 1964) and related acts require the U.S. Geological Survey and the U.S. Bureau of Mines to survey certain areas on Federal lands to determine the mineral values, if any, that may be present. Results must be made available to the public and to be submitted to the President and Congress. This report presents the results of a geologic survey of the Three <span class="hlt">Sisters</span> Wilderness, Deschutes and Willamette National Forests, Deschutes, Lane and Linn Counties, Oregon</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=221992','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=221992"><span id="translatedtitle">Sudden <span class="hlt">Death</span> Syndrome</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Sudden <span class="hlt">death</span> syndrome (SDS) is an important disease of soybean in North and South America. SDS first occurred in South America in the early 1990s. In the U.S.A., SDS was first detected in AK in 1971. Now SDS occurs in most soybean production areas of the U.S. The SDS pathogen is a soil-borne fungu...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Capital+AND+punishment&pg=4&id=EJ409542','ERIC'); return false;" href="http://eric.ed.gov/?q=Capital+AND+punishment&pg=4&id=EJ409542"><span id="translatedtitle">The <span class="hlt">Death</span> Penalty.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Crockett, Mark</p> <p>1990-01-01</p> <p>Provides a lesson plan on the Eighth Amendment to the U.S. Constitution and the imposition of the <span class="hlt">death</span> penalty. Focuses on the controversy concerning capital punishment and stimulates critical thinking in an analysis and discussion of eight hypothetical situations. Includes suggestions for readings, videotapes, and writing assignments. (NL)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Tumor&pg=5&id=EJ487867','ERIC'); return false;" href="http://eric.ed.gov/?q=Tumor&pg=5&id=EJ487867"><span id="translatedtitle"><span class="hlt">Death</span> of a Leader.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McLaughlin, Thomas E.</p> <p>1994-01-01</p> <p>When Issaquah (Washington) superintendent, after battling a brain tumor, entered the hospital for the last time, school district had to develop a crisis plan to deal with the possible <span class="hlt">death</span> of the superintendent. A contingency planning team developed a telephone tree for school officials to keep in close contact with teachers and administrators.…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3805564','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3805564"><span id="translatedtitle">Digital Language <span class="hlt">Death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kornai, András</p> <p>2013-01-01</p> <p>Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language <span class="hlt">death</span>, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide. PMID:24167559</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3093212','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3093212"><span id="translatedtitle">Diagnosis of brain <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Machado, Calixto</p> <p>2010-01-01</p> <p>Brain <span class="hlt">death</span> (BD) should be understood as the ultimate clinical expression of a brain catastrophe characterized by a complete and irreversible neurological stoppage, recognized by irreversible coma, absent brainstem reflexes, and apnea. The most common pattern is manifested by an elevation of intracranial pressure to a point beyond the mean arterial pressure, and hence cerebral perfusion pressure falls and, as a result, no net cerebral blood flow is present, in due course leading to permanent cytotoxic injury of the intracranial neuronal tissue. A second mechanism is an intrinsic injury affecting the nervous tissue at a cellular level which, if extensive and unremitting, can also lead to BD. We review here the methodology of diagnosing <span class="hlt">death</span>, based on finding any of the signs of <span class="hlt">death</span>. The irreversible loss of cardio-circulatory and respiratory functions can cause <span class="hlt">death</span> only when ischemia and anoxia are prolonged enough to produce an irreversible destruction of the brain. The sign of such loss of brain functions, that is to say BD diagnosis, is fully reviewed. PMID:21577338</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Immunology&pg=6&id=ED219367','ERIC'); return false;" href="http://eric.ed.gov/?q=Immunology&pg=6&id=ED219367"><span id="translatedtitle">Sudden Infant <span class="hlt">Death</span> Syndrome.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Barnett, Henry L.; And Others</p> <p></p> <p>There is a growing body of evidence that Sudden Infant <span class="hlt">Death</span> Syndrome (SIDS) victims are not completely normal and healthy, as was once believed. A variety of new information from several disciplines strongly suggests that the infant who dies suddenly and unexpectedly may do so because of subtle developmental, neurologic, cardiorespiratory, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24167559','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24167559"><span id="translatedtitle">Digital language <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kornai, András</p> <p>2013-01-01</p> <p>Of the approximately 7,000 languages spoken today, some 2,500 are generally considered endangered. Here we argue that this consensus figure vastly underestimates the danger of digital language <span class="hlt">death</span>, in that less than 5% of all languages can still ascend to the digital realm. We present evidence of a massive die-off caused by the digital divide. PMID:24167559</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_15");'>15</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li class="active"><span>17</span></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_17 --> <div id="page_18" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="341"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24851802','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24851802"><span id="translatedtitle">Childhood obsessive-compulsive traits in anorexia nervosa patients, their unaffected <span class="hlt">sisters</span> and healthy controls: a retrospective study.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Degortes, Daniela; Zanetti, Tatiana; Tenconi, Elena; Santonastaso, Paolo; Favaro, Angela</p> <p>2014-07-01</p> <p>Although there is evidence that childhood perfectionistic traits predate the onset of eating disorders, few studies to date have examined the prevalence and clinical correlates of these traits in patients with anorexia nervosa (AN) and their unaffected <span class="hlt">sisters</span>. The aim of this work was to study the prevalence of childhood obsessive-compulsive traits in patients with lifetime AN, their unaffected <span class="hlt">sisters</span> and healthy women. A total of 116 AN patients, 32 healthy <span class="hlt">sisters</span> and 119 controls were assessed by the EATATE Interview to assess traits such as perfectionism, inflexibility, rule-bound traits, drive for order and symmetry, and excessive doubt and cautiousness. Both self-report and maternal reports were collected. AN patients reported more childhood obsessive-compulsive traits than their healthy <span class="hlt">sisters</span> and controls. In contrast, no differences between healthy controls and unaffected <span class="hlt">sisters</span> emerged. In patients with AN, a dose-response relationship was found between the number of childhood obsessive-compulsive traits and psychopathology, including body image distortion, thus indicating that these traits are an important feature to be considered in assessing and treating eating disorders. PMID:24851802</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18639540','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18639540"><span id="translatedtitle">Securin and not CDK1/cyclin B1 regulates <span class="hlt">sister</span> chromatid disjunction during meiosis II in mouse eggs.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nabti, Ibtissem; Reis, Alexandra; Levasseur, Mark; Stemmann, Olaf; Jones, Keith T</p> <p>2008-09-15</p> <p>Mammalian eggs remain arrested at metaphase of the second meiotic division (metII) for an indeterminate time before fertilization. During this period, which can last several hours, the continued attachment of <span class="hlt">sister</span> chromatids is thought to be achieved by inhibition of the protease separase. Separase is known to be inhibited by binding either securin or Maturation (M-Phase)-Promoting Factor, a heterodimer of CDK1/cyclin B1. However, the relative contribution of securin and CDK/cyclin B1 to <span class="hlt">sister</span> chromatid attachment during metII arrest has not been assessed. Although there are conditions in which either CDK1/cyclinB1 activity or securin can prevent <span class="hlt">sister</span> chromatid disjunction, principally by overexpression of non-degradable cyclin B1 or securin, we find here that separase activity is primarily regulated by securin and not CDK1/cyclin B1. Thus the CDK1 inhibitor roscovitine and an antibody we designed to block the interaction of CDK1/cyclin B1 with separase, both failed to induce <span class="hlt">sister</span> disjunction. In contrast, securin morpholino knockdown specifically induced loss of <span class="hlt">sister</span> attachment, that could be restored by securin cRNA rescue. During metII arrest separase appears primarily regulated by securin binding, not CDK1/cyclin B1. PMID:18639540</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2002JPhA...35.9309W','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2002JPhA...35.9309W"><span id="translatedtitle">Population <span class="hlt">death</span> sequences and Cox processes driven by interacting Feller diffusions</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Wei, Gang; Clifford, Peter; Feng, Jianfeng</p> <p>2002-11-01</p> <p>We carry out a complete study on the relationship between Cox processes driven by interacting Feller diffusions and <span class="hlt">death</span> sequences of immigration-emigration <span class="hlt">linked</span> population networks. It is first proved that the Cox process driven by a Feller diffusion is equivalent to the <span class="hlt">death</span> sequence of a birth and <span class="hlt">death</span> process. The conclusion is then generalized to the case of Cox processes driven by interacting Feller diffusions and <span class="hlt">death</span> sequences of interacting populations.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20010290','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20010290"><span id="translatedtitle">Adolescent Russian roulette <span class="hlt">deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Collins, Kim A</p> <p>2010-03-01</p> <p>Adolescence, between the ages of 10 and 19 years, is a unique period both physically and emotionally. During this time of life, individuals are known to experiment and engage in risky behavior, sometimes with unforeseen morbidity and mortality. We also see suicide emerge as a manner of <span class="hlt">death</span> in this age group. The most common method is gunshot wound and sometimes in the form of Russian roulette. Few studies have looked at <span class="hlt">deaths</span> by Russian roulette, the victims, and scenarios. In particular, no study examines the adolescent victim of Russian roulette. To better understand and classify this entity, adolescent Russian roulette autopsy cases over a 20-year period were examined looking at the victims, scenarios, autopsy findings, cause and manner of <span class="hlt">death</span>, and the weapons. All victims were males, ages 13 to 19 years, with a Black-to-White ratio of 1:1. No victim had a previous psychiatric history. Toxicology was positive for alcohol and/or marijuana in 50% of the victims. Friends were present when the victim shot himself which occurred in the home the majority of the time. In all but 1 case, premeditation of the game was involved as the victim provided the weapon for the roulette. The cause of <span class="hlt">death</span> was gunshot wound to the head (6 to the right side, 1 to the mouth, 1 to the forehead), and the manner of <span class="hlt">death</span> was suicide in 6 cases and accident in 2 cases. A review of the literature discusses the adolescent victim, suicide, and Russian roulette. PMID:20010290</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25640518','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25640518"><span id="translatedtitle">A novel <span class="hlt">sister</span> clade to the enterobacteria microviruses (family Microviridae) identified in methane seep sediments.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bryson, Samuel Joseph; Thurber, Andrew R; Correa, Adrienne M S; Orphan, Victoria J; Vega Thurber, Rebecca</p> <p>2015-10-01</p> <p>Methane seep microbial communities perform a key ecosystem service by consuming the greenhouse gas methane prior to its release into the hydrosphere, minimizing the impact of marine methane sources on our climate. Although previous studies have examined the ecology and biochemistry of these communities, none has examined viral assemblages associated with these habitats. We employed virus particle purification, genome amplification, pyrosequencing and gene/genome reconstruction and annotation on two metagenomic libraries, one prepared for ssDNA and the other for all DNA, to identify the viral community in a methane seep. Similarity analysis of these libraries (raw and assembled) revealed a community dominated by phages, with a significant proportion of similarities to the Microviridae family of ssDNA phages. We define these viruses as the Eel River Basin Microviridae (ERBM). Assembly and comparison of 21 ERBM closed circular genomes identified five as members of a novel <span class="hlt">sister</span> clade to the Microvirus genus of Enterobacteria phages. Comparisons among other metagenomes and these Microviridae major-capsid sequences indicated that this clade of phages is currently unique to the Eel River Basin sediments. Given this ERBM clade's relationship to the Microviridae genus Microvirus, we define this <span class="hlt">sister</span> clade as the candidate genus Pequeñovirus. PMID:25640518</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27252897','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27252897"><span id="translatedtitle">ADA2 deficiency: case report of a new phenotype and novel mutation in two <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Uettwiller, F; Sarrabay, G; Rodero, M P; Rice, G I; Lagrue, E; Marot, Y; Deiva, K; Touitou, I; Crow, Y J; Quartier, P</p> <p>2016-01-01</p> <p>The objective of this paper is to: describe the phenotype compound heterozygote for mutations in CECR1 in two children. We describe the clinical and immunological phenotype, including the assessment of ADA2 activity, cytokine expression, interferon-stimulated and neutrophil-stimulated gene signatures, and the results of CECR1 sequencing. The first patient presented with intermittent fever, cutaneous vasculitis, myalgia and muscle inflammation on MRI leading to a provisional diagnosis of periarteritis nodosa. Subsequently, two cerebral lacunar lesions were identified following a brain stroke. Clinical features improved on anti-tumour necrosis factor therapy. The first patient's <span class="hlt">sister</span> demonstrated early-onset, long-lasting anaemia with mild biological inflammation; at the ages of 3 and 5 years, she had presented 2 acute, transient neurological events with lacunar lesions on MRI. CECR1 sequencing identified both <span class="hlt">sisters</span> to be compound heterozygous for a p.Tyr453Cys mutation and a previously undescribed deletion of exon 7. ADA2 activity was reduced by 50%. Neutrophil-stimulated genes were not overexpressed, but interferon-stimulated genes were. The expression of a panel of other cytokine transcripts was not significantly altered. In conclusion, searching for CECR1 mutation or assessing ADA2 activity should be considered in patients with an atypical presentation of inflammatory disease. PMID:27252897</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3685581','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3685581"><span id="translatedtitle">Genomic basis of ecological niche divergence among cryptic <span class="hlt">sister</span> species of non-biting midges</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2013-01-01</p> <p>Background There is a lack of understanding the evolutionary forces driving niche segregation of closely related organisms. In addition, pinpointing the genes driving ecological divergence is a key goal in molecular ecology. Here, larval transcriptome sequences obtained by next-generation-sequencing are used to address these issues in a morphologically cryptic <span class="hlt">sister</span> species pair of non-biting midges (Chironomus riparius and C. piger). Results More than eight thousand orthologous open reading frames were screened for interspecific divergence and intraspecific polymorphisms. Despite a small mean sequence divergence of 1.53% between the <span class="hlt">sister</span> species, 25.1% of 18,115 observed amino acid substitutions were inferred by α statistics to be driven by positive selection. Applying McDonald-Kreitman tests to 715 alignments of gene orthologues identified eleven (1.5%) genes driven by positive selection. Conclusions Three candidate genes were identified as potentially responsible for the observed niche segregation concerning nitrite concentration, habitat temperature and water conductivity. Additionally, signs of positive selection in the hydrogen sulfide detoxification pathway were detected, providing a new plausible hypothesis for the species’ ecological differentiation. Finally, a divergently selected, nuclear encoded mitochondrial ribosomal protein may contribute to reproductive isolation due to cytonuclear coevolution. PMID:23758757</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4254975','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4254975"><span id="translatedtitle">Different Parasite Faunas in Sympatric Populations of <span class="hlt">Sister</span> Hedgehog Species in a Secondary Contact Zone</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pfäffle, Miriam; Černá Bolfíková, Barbora; Hulva, Pavel; Petney, Trevor</p> <p>2014-01-01</p> <p>Providing descriptive data on parasite diversity and load in <span class="hlt">sister</span> species is a first step in addressing the role of host-parasite coevolution in the speciation process. In this study we compare the parasite faunas of the closely related hedgehog species Erinaceus europaeus and E. roumanicus from the Czech Republic where both occur in limited sympatry. We examined 109 hedgehogs from 21 localities within this secondary contact zone. Three species of ectoparasites and nine species of endoparasites were recorded. Significantly higher abundances and prevalences were found for Capillaria spp. and Brachylaemus erinacei in E. europaeus compared to E. roumanicus and higher mean infection rates and prevalences for Hymenolepis erinacei, Physaloptera clausa and Nephridiorhynchus major in E. roumanicus compared to E. europaeus. Divergence in the composition of the parasite fauna, except for Capillaria spp., which seem to be very unspecific, may be related to the complicated demography of their hosts connected with Pleistocene climate oscillations and consequent range dynamics. The fact that all parasite species with different abundances in E. europaeus and E. roumanicus belong to intestinal forms indicates a possible diversification of trophic niches between both <span class="hlt">sister</span> hedgehog species. PMID:25469872</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24815211','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24815211"><span id="translatedtitle">Tracheole investment does not vary with body size among bumblebee (Bombus impatiens) <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Vogt, Jessica R; Dillon, Megan K; Dillon, Michael E</p> <p>2014-08-01</p> <p>Body size is a key organism trait with critical implications for the physiology, life history, and ecology of organisms. Modern insects vary in body mass by over 6 orders of magnitude, but are small by comparison to many other metazoan taxa. The small size of modern insects may reflect limitations imposed by their open respiratory systems which rely, in part, on diffusion. Diffusion rates decline with distance such that, absent compensation, the capacity for larger insects to deliver oxygen to their tissues may be compromised. To compensate, larger grasshoppers, beetles, and bumblebees devote proportionally more of their body volume to the respiratory system, as demonstrated by hypermetric scaling of tracheal volume with body mass(>1). Among bumblebee <span class="hlt">sisters</span>, total respiratory volume scaled with mass(2.6), but it is unclear at what level or levels of the tracheal system (main tracheal trunks, air sacs, tracheoles) bumblebees express this extreme hypermetry. Here we use transmission electron microscopy to examine the morphology of tracheoles in bumblebee flight muscle among <span class="hlt">sister</span> bumblebees varying nearly four-fold in body mass. Neither tracheole density nor tracheole diameter changed with body mass. The total cross-sectional area of tracheoles was also invariant with body mass. Together, these results reveal that bumblebees do not compensate for size-related limitations on oxygen delivery by increasing investment at the level of the tracheoles. PMID:24815211</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5025379','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5025379"><span id="translatedtitle">Origins of dacite and rhyodacite of the South <span class="hlt">Sister</span> magmatic system, central high Cascades, Oregon</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Price, J.D.; Parker, D.F. )</p> <p>1993-04-01</p> <p>A gap from 66 to 72 weight percent silica (48--62 ppm Rb) separates dacite from rhyodacite of the South <span class="hlt">Sister</span> system. The authors results indicate that rhyodacite can not be produced by fractional crystallization from dacite. Variation among rhyodacite and associated rhyolite is, however, most likely the result of fractional crystallization, in agreement with previous studies. Dacite in the South <span class="hlt">Sister</span> system probably had multiple origins, as suggested by trace element plots for Y, Nb and Zr. Some dacite was produced by fractional crystallization from andesitic magmas, while others were largely the result of mixing between andesite and rhyodacite. Mafic enclaves occurring in dacite are compositional similar to Holocene basalt, and their mixing with dacitic magma may have triggered eruptions, but they are probably not directly related genetically to their host rocks. The rhyodacites are probably crustal melts. Previous workers have suggested high-level melting of hypabyssal silicic plutons or amphibolite sources for the rhyodacites. The authors suggest melting of granitic plutonic sources, similar to those exposed in the Klamath Mountains, for the origin of the rhyodacites.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25469872','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25469872"><span id="translatedtitle">Different parasite faunas in sympatric populations of <span class="hlt">sister</span> hedgehog species in a secondary contact zone.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pfäffle, Miriam; Černá Bolfíková, Barbora; Hulva, Pavel; Petney, Trevor</p> <p>2014-01-01</p> <p>Providing descriptive data on parasite diversity and load in <span class="hlt">sister</span> species is a first step in addressing the role of host-parasite coevolution in the speciation process. In this study we compare the parasite faunas of the closely related hedgehog species Erinaceus europaeus and E. roumanicus from the Czech Republic where both occur in limited sympatry. We examined 109 hedgehogs from 21 localities within this secondary contact zone. Three species of ectoparasites and nine species of endoparasites were recorded. Significantly higher abundances and prevalences were found for Capillaria spp. and Brachylaemus erinacei in E. europaeus compared to E. roumanicus and higher mean infection rates and prevalences for Hymenolepis erinacei, Physaloptera clausa and Nephridiorhynchus major in E. roumanicus compared to E. europaeus. Divergence in the composition of the parasite fauna, except for Capillaria spp., which seem to be very unspecific, may be related to the complicated demography of their hosts connected with Pleistocene climate oscillations and consequent range dynamics. The fact that all parasite species with different abundances in E. europaeus and E. roumanicus belong to intestinal forms indicates a possible diversification of trophic niches between both <span class="hlt">sister</span> hedgehog species. PMID:25469872</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4879337','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4879337"><span id="translatedtitle">ADA2 deficiency: case report of a new phenotype and novel mutation in two <span class="hlt">sisters</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Uettwiller, F; Sarrabay, G; Rodero, M P; Rice, G I; Lagrue, E; Marot, Y; Deiva, K; Touitou, I; Crow, Y J; Quartier, P</p> <p>2016-01-01</p> <p>The objective of this paper is to: describe the phenotype compound heterozygote for mutations in CECR1 in two children. We describe the clinical and immunological phenotype, including the assessment of ADA2 activity, cytokine expression, interferon-stimulated and neutrophil-stimulated gene signatures, and the results of CECR1 sequencing. The first patient presented with intermittent fever, cutaneous vasculitis, myalgia and muscle inflammation on MRI leading to a provisional diagnosis of periarteritis nodosa. Subsequently, two cerebral lacunar lesions were identified following a brain stroke. Clinical features improved on anti-tumour necrosis factor therapy. The first patient's <span class="hlt">sister</span> demonstrated early-onset, long-lasting anaemia with mild biological inflammation; at the ages of 3 and 5 years, she had presented 2 acute, transient neurological events with lacunar lesions on MRI. CECR1 sequencing identified both <span class="hlt">sisters</span> to be compound heterozygous for a p.Tyr453Cys mutation and a previously undescribed deletion of exon 7. ADA2 activity was reduced by 50%. Neutrophil-stimulated genes were not overexpressed, but interferon-stimulated genes were. The expression of a panel of other cytokine transcripts was not significantly altered. In conclusion, searching for CECR1 mutation or assessing ADA2 activity should be considered in patients with an atypical presentation of inflammatory disease. PMID:27252897</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26400565','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26400565"><span id="translatedtitle">[Cell <span class="hlt">death</span> in malignant tumors. Relevance of cell <span class="hlt">death</span> regulation for metastasis].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Roth, W</p> <p>2015-11-01</p> <p>Defects in the regulation of cell <span class="hlt">death</span> are important causes for both the development and therapy resistance of malignant tumors. Several distinct, molecularly defined types of cell <span class="hlt">death</span> are known, such as apoptosis, anoikis, and necroptosis. Moreover, the specific triggering of cell <span class="hlt">death</span> plays an important role in the prevention of metastasis. The results of recent studies have shown that various types of cell <span class="hlt">death</span> are pivotal at different steps of the metastasis cascade, in order to prevent cellular detachment, migration, invasion, intravasation, extravasation and the establishment of micrometastasis and macrometastasis. At the subcellular level, numerous <span class="hlt">links</span> exist between cell <span class="hlt">death</span> regulation and metastasis, specifically regarding signaling pathways and individual proteins with dual or multiple functions. As an example, the decoy receptor 3 protein (DcR3) functions both as an anti-apoptotic protein and as a direct promotor of invasion and migration of tumor cells. In summary, the specific triggering of cell <span class="hlt">death</span> plays a pivotal role for the prevention of metastasis. On the other hand, the stepwise process of metastasis represents a mechanism of selection resulting in established metastases with a multiresistant phenotype which corresponds to the clinical observation that many metastasized cancers are therapy resistant. In the future, innovative diagnostic tests to individually predict the resistance pattern and possibilities to overcome resistance are urgently needed. PMID:26400565</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24834668','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24834668"><span id="translatedtitle">Near-<span class="hlt">death</span> experiences and the psychology of <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tassell-Matamua, Natasha A</p> <p></p> <p>Little is known about the psychological phenomenology of <span class="hlt">death</span>. Reported across known history and in all cultures by those who have died or been close to <span class="hlt">death</span>, NDEs challenge objective-mechanistic models by suggesting the phenomenology of <span class="hlt">death</span> may involve a variety of complex psychological processes. This article discusses three notable characteristics of the NDE--loss of the fear of <span class="hlt">death</span>, psychological sequelae, and complex conscious abilities--supporting this claim. The implications these have for advancing societal understandings of <span class="hlt">death</span> are discussed, and their pragmatic application for professions where <span class="hlt">death</span> is frequently encountered, such as palliative care, is addressed. PMID:24834668</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26387792','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26387792"><span id="translatedtitle">X-<span class="hlt">linked</span> dominant protoporphyria: The first reported Japanese case.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ninomiya, Yukiko; Kokunai, Yasuhito; Tanizaki, Hideaki; Akasaka, Eijiro; Nakano, Hajime; Moriwaki, Shinichi</p> <p>2016-04-01</p> <p>A 12-year-old boy with photosensitivity since 3 years of age presented with small concavities on both cheeks, the nasal root and the dorsal surface of both hands. According to the clinical features, erythropoietic protoporphyria (EPP) was suspected. Urine and blood samples were tested for porphyrin derivatives, which revealed a markedly elevated level of erythrocyte protoporphyrin (EP) and a diagnosis of EPP was made. The patient's mother had no photosensitivity, however, lesions appearing slightly as small scars were found on the dorsum of her right hand; his elder <span class="hlt">sister</span> and father showed no rash. The EP levels were elevated in samples from his mother and mildly elevated in those from his elder <span class="hlt">sister</span> and father. To obtain a definitive diagnosis, genetic analyses were performed using samples from all family members, which revealed no mutations in the ferrochelatase-encoding gene (FECH), which is responsible for EPP. Instead, a pathological mutation of the 5-aminolevulinic acid synthase-encoding gene (ALAS2) was identified in samples from the patient, his mother and his elder <span class="hlt">sister</span>, confirming a definitive diagnosis of X-<span class="hlt">linked</span> dominant protoporphyria (XLDPP). This is the first Japanese family reported to have XLDPP, demonstrating evidence of the condition in Japan. In addition, because XLDPP is very similar to EPP in its clinical aspects and laboratory findings, a genetic analysis is required for the differential diagnosis. PMID:26387792</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27150866','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27150866"><span id="translatedtitle">Two <span class="hlt">Sisters</span> with Graves' Disease and Similar Clinical Features who Tested Positive for Anti-insulin Antibodies after Thiamazole Treatment.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Torimoto, Keiichi; Okada, Yosuke; Mori, Hiroko; Tanaka, Yoshiya</p> <p>2016-01-01</p> <p>The older of a pair of <span class="hlt">sisters</span> experienced hypoglycemia after the start of thiamazole (MMI) treatment. Based on a high insulin antibody level, she was diagnosed with insulin autoimmune syndrome (IAS). HLA-DNA typing identified DRB1*04:06. Although a 75-g oral glucose tolerance test (OGTT) showed biphasic insulin secretion, the secretion pattern became monophasic after discontinuation of the MMI. The younger <span class="hlt">sister</span> was diagnosed with IAS after the start of MMI treatment. HLA-DNA typing identified DRB1*04:06. The 75-g OGTT showed biphasic insulin secretion, but it became monophasic after discontinuation of the MMI. According to the similar insulin secretion kinetics in the two <span class="hlt">sisters</span> with IAS, we suspect that a genetic predisposition may be associated with the features of anti-insulin antibodies. PMID:27150866</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12159274','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12159274"><span id="translatedtitle">Reducing <span class="hlt">deaths</span> from pregnancy and childbirth. Asia.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Pillai, G</p> <p>1993-01-01</p> <p>99% of all maternal <span class="hlt">deaths</span> occur in the developing world, and South Asian countries account for most <span class="hlt">deaths</span>. The causes are obstructed labor, hemorrhage, pregnancy-related hypertension (eclampsia), or unsafe abortion. The United Nation's Children's Fund estimates 340 maternal <span class="hlt">deaths</span> for every 100,000 live births in India. In Indian rural areas, the maternal mortality rate is between 800 and 900 <span class="hlt">deaths</span> per 100,000 live births in Bangladesh, 600; in Nepal, 830; and in Bhutan, 1710. IN comparison, the rate in the United States is 8 <span class="hlt">deaths</span> per 100,000 live births. The technology for reducing maternal mortality has been utilized in most developed countries, as well as in parts of South Asia, in particular in Sri Lanka. The goal of the Safe Motherhood Initiative was to reduce maternal mortality by 50% by the year 2000. The immediate causes of maternal mortality include pregnancy and delivery and the management of complications such as hemorrhage, toxic and bacterial infections (sepsis), eclampsia, and obstructed labor. The poor health, nutrition, and socioeconomic status of women are the underlying causes of maternal <span class="hlt">death</span>. One study in India found that inadequate medical treatment contributes to 36% to 47% of maternal <span class="hlt">deaths</span> in hospitals. In India, abortion services are legal and acceptable on social, religious, and political grounds, but services are inaccessible. In Bangladesh, the availability of menstrual regulation is estimated to save 100,000 to 160,000 women from unsafe abortions each year. However, the inaccessibility of this service accounts for 700,000 unsafe abortions and 7000 maternal <span class="hlt">deaths</span>. Gender bias in the allocation of meager food supplies results in the poor health and nutritional status of women, rendering a woman's pelvis too small, which causes obstructed labor and even <span class="hlt">death</span>. Socioeconomic status is <span class="hlt">linked</span> to access the family planning and health services which affect mortality and reproductive health. In Sri Lanka and Kerala, government</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/9464913','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/9464913"><span id="translatedtitle">Sudden <span class="hlt">death</span> of feedlot cattle.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Glock, R D; DeGroot, B D</p> <p>1998-01-01</p> <p>Sudden <span class="hlt">deaths</span> or the sudden <span class="hlt">death</span> syndrome are perceived as major concerns in cattle feedlots because most of these <span class="hlt">deaths</span> occur in cattle near market weight. Etiology and preventive measures are poorly defined. The current literature indicates that sudden <span class="hlt">deaths</span> are associated most commonly with digestive upsets. <span class="hlt">Death</span> is thought to be the result of interactions between factors including acidosis, bloat, and endotoxemia. Trauma, peracute interstitial pneumonia, and other identifiable events are specifically defined but relatively uncommon. Enterotoxemia is of questionable significance as a cause of sudden <span class="hlt">deaths</span>. PMID:9464913</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/11037214','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/11037214"><span id="translatedtitle">Negotiating natural <span class="hlt">death</span> in intensive care.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Seymour, J E</p> <p>2000-10-01</p> <p>Recent empirical evidence of barriers to palliative care in acute hospital settings shows that dying patients may receive invasive medical treatments immediately before <span class="hlt">death</span>, in spite of evidence of their poor prognosis being available to clinicians. The difficulties of ascertaining treatment preferences, predicting the trajectory of dying in critically ill people, and assessing the degree to which further interventions are futile are well documented. Further, enduring ethical complexities attending end of life care mean that the process of withdrawing or withholding medical care is associated with significant problems for clinical staff. Specific difficulties attend the legitimation of treatment withdrawal, the perceived differences between 'killing' and 'letting die' and the cultural constraints which attend the orchestration of 'natural' <span class="hlt">death</span> in situations where human agency is often required before <span class="hlt">death</span> can follow dying. This paper draws on ethnographic research to examine the way in which these problems are resolved during medical work within intensive care. Building on insights from the literature, an analysis of observational case study data is presented which suggests that the negotiation of natural <span class="hlt">death</span> in intensive care hinges upon four strategies. These, which form a framework with which to interpret social interaction between physicians during end of life decision-making in intensive care, are as follows: firstly, the establishment of a 'technical' definition of dying--informed by results of investigations and monitoring equipment--over and above 'bodily' dying informed by clinical experience. Secondly, the alignment of the trajectories of technical and bodily dying to ensure that the events of non-treatment have no perceived causative <span class="hlt">link</span> to <span class="hlt">death</span>. Thirdly, the balancing of medical action with non-action, allowing a diffusion of responsibility for <span class="hlt">death</span> to the patient's body; and lastly, the incorporation of patient's companions and nursing staff</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4905191','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4905191"><span id="translatedtitle">Mitochondrial <span class="hlt">death</span> functions of p53</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Marchenko, N D; Moll, U M</p> <p>2014-01-01</p> <p>The p53 tumor suppressor network plays a fundamental surveillance role in both homeostatic and adaptive cell biology. p53 is one of the most important barriers against malignant derailment of normal cells, orchestrating growth arrest, senescence, or cell <span class="hlt">death</span> by <span class="hlt">linking</span> many different pathways in response to genotoxic and non-genotoxic insults. p53 is the key broadband sensor for numerous cellular stresses such as DNA damage, hypoxia, oxidative stress, oncogenic signaling, and nucleolar stress. The crucial tumor suppressive and tissue homeostasis activity of p53 is its ability to activate cell <span class="hlt">death</span> via multiple different pathways. A well-characterized biochemical function of p53 in the regulation of apoptosis is its role as a potent transcriptional regulator. p53 activates a panel of proapoptotic genes from the mitochondrial apoptotic and <span class="hlt">death</span> receptor programs while repressing antiapoptotic Bcl2 family genes. In addition, over the last 10 y a growing body of evidence has also defined direct extranuclear non-transcriptional p53 activities within mitochondria-mediated cell <span class="hlt">death</span> pathways that are based on p53 protein accumulation in cytosolic and mitochondrial compartments and protein-protein interactions. To date, transcription-independent p53-mediated cell <span class="hlt">death</span> regulation has been described for apoptosis, necrosis, and autophagy. Because mitochondrial dysregulation is central to the development of a number of pathologic processes such as cancer and neurodegenerative and age-related diseases, understanding the direct roles of p53 protein in mitochondria has high translational impact and could facilitate the development of novel drug targets to combat these diseases. In this review we will mainly focus on mechanisms of p53-mediated transcription-independent cell <span class="hlt">death</span> pathways at mitochondria. PMID:27308326</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_16");'>16</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li class="active"><span>18</span></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_18 --> <div id="page_19" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="361"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2316801','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2316801"><span id="translatedtitle">Emergency department <span class="hlt">deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Webb, G L; McSwain, N E; Webb, W R; Rodriguez, C</p> <p>1990-04-01</p> <p>This study reviews 186 <span class="hlt">deaths</span> resulting from trauma in a 2-year period in the Charity Hospital of Louisiana at New Orleans Accident Room in order to evaluate problems in prehospital and hospital resuscitative care. All subjects underwent autopsy, and only six were found to have injuries compatible with survival. Three of these were late arrivals (by transfer or self-imposed delay) and died of protracted hemorrhage. Only three <span class="hlt">deaths</span> occurring in the Emergency Department itself were found to have been potentially preventable. The important factors in maximizing survival of trauma patients remain rapid transport; immediate, appropriate, rapid evaluation; and quick diagnosis, resuscitation, and definitive therapy. These require a well-trained emergency medical ambulance service delivering patients quickly to a hospital designed to handle trauma patients. One person, preferably a general surgeon with trauma experience, should supervise and monitor the patient continually until the resuscitation phase and all diagnostic tests are completed and definitive therapy is initiated. PMID:2316801</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18389861','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18389861"><span id="translatedtitle">[<span class="hlt">Death</span> after anal "fisting"].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Preuss, Johanna; Strehler, Marco; Dettmeyer, Reinhard; Madea, Burkhard</p> <p>2008-01-01</p> <p>A 45-year-old homeless woman was found dead at her usual sleeping place. Apart from traces of blood on the lower abdomen of the body, the police investigations did not produce any clues pointing to an unnatural <span class="hlt">death</span>. At autopsy, it was found, however, that <span class="hlt">death</span> had been caused by extensive disruptions of the intestine. After being confronted with the results, the sexual partner of the victim admitted manual anal penetration, but claimed that this had been done by mutual agreement. The court did not accept that statement and sentenced him to life imprisonment for murder. The frequency of such fatal outcomes of anal penetration, the relationship between the perpetrator and the victim and the special features at the scene are discussed. PMID:18389861</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16001791','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16001791"><span id="translatedtitle">[Karoshi, <span class="hlt">death</span> by overwork].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Uehata, Tetsunojo</p> <p>2005-07-01</p> <p>Karoshi (<span class="hlt">death</span> by overwork) is one of social medical terms, which used by survivors of victims who attacked with cardiovascular diseases such as stroke, myocardial infarction and sudden cardiac <span class="hlt">death</span>. In Dec. 2000, Compensation Standard of cardiovascular diseases in Workers' Insurance was changed and admitted the relationship between chronic fatigue and cardiovascular attacks. As a result, compensation numbers of Karoshi attributed to three hundred and more from about 80 cases. The Ministry of Health, Labour and Welfare thinks that most of Karoshi caused by long working hours continuing for several months, especially without payment, so that the Labour Standard Inspector Office requests to decrease overtime work more than 45 hours per month to firm administrators. PMID:16001791</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/7262664','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/7262664"><span id="translatedtitle">Atypical autoerotic <span class="hlt">deaths</span></span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Gowitt, G.T.; Hanzlick, R.L. )</p> <p>1992-06-01</p> <p>So-called typical' autoerotic fatalities are the result of asphyxia due to mechanical compression of the neck, chest, or abdomen, whereas atypical' autoeroticism involves sexual self-stimulation by other means. The authors present five atypical autoerotic fatalities that involved the use of dichlorodifluoromethane, nitrous oxide, isobutyl nitrite, cocaine, or compounds containing 1-1-1-trichloroethane. Mechanisms of <span class="hlt">death</span> are discussed in each case and the pertinent literature is reviewed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18171280','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18171280"><span id="translatedtitle">Evidence for a heritable predisposition to <span class="hlt">death</span> due to influenza.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Albright, Frederick S; Orlando, Patricia; Pavia, Andrew T; Jackson, George G; Cannon Albright, Lisa A</p> <p>2008-01-01</p> <p>Animal model studies and human epidemiological studies have shown that some infectious diseases develop primarily in individuals with an inherited predisposition. A heritable contribution to the development of severe influenza virus infection (i.e., that which results in <span class="hlt">death</span>) has not previously been hypothesized or tested. Evidence for a heritable contribution to <span class="hlt">death</span> due to influenza was examined using a resource consisting of a genealogy of the Utah population <span class="hlt">linked</span> to <span class="hlt">death</span> certificates in Utah over a period of 100 years. The relative risks of <span class="hlt">death</span> due to influenza were estimated for the relatives of 4,855 individuals who died of influenza. Both close and distant relatives of individuals who died of influenza were shown to have a significantly increased risk of dying of influenza, consistent with a combination of shared exposure and genetic effects. These data provide strong support for a heritable contribution to predisposition to <span class="hlt">death</span> due to influenza. PMID:18171280</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26423135','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26423135"><span id="translatedtitle">The lethal response to Cdk1 inhibition depends on <span class="hlt">sister</span> chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Voets, Erik; Marsman, Judith; Demmers, Jeroen; Beijersbergen, Roderick; Wolthuis, Rob</p> <p>2015-01-01</p> <p>Cyclin-dependent kinase 1 (Cdk1) is absolutely essential for cell division. Complete ablation of Cdk1 precludes the entry of G2 phase cells into mitosis, and is early embryonic lethal in mice. Dampening Cdk1 activation, by reducing gene expression or upon treatment with cell-permeable Cdk1 inhibitors, is also detrimental for proliferating cells, but has been associated with defects in mitotic progression, and the formation of aneuploid daughter cells. Here, we used a large-scale RNAi screen to identify the human genes that critically determine the cellular toxicity of Cdk1 inhibition. We show that Cdk1 inhibition leads to fatal <span class="hlt">sister</span> chromatid alignment errors and mitotic arrest in the spindle checkpoint. These problems start early in mitosis and are alleviated by depletion of isoform 1 of PRC1 (PRC1-1), by gene ablation of its binding partner KIF4, or by abrogation of KIF4 motor activity. Our results show that, normally, Cdk1 activity must rise above the level required for mitotic entry. This prevents KIF4-dependent PRC1-1 translocation to astral microtubule tips and safeguards proper chromosome congression. We conclude that cell <span class="hlt">death</span> in response to Cdk1 inhibitors directly relates to chromosome alignment defects generated by insufficient repression of PRC1-1 and KIF4 during prometaphase. PMID:26423135</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&id=EJ1005425','ERIC'); return false;" href="http://eric.ed.gov/?q=death&id=EJ1005425"><span id="translatedtitle">A <span class="hlt">Death</span> in the Family: <span class="hlt">Death</span> as a Zen Concept</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Black, Helen K.; Rubinstein, Robert L.</p> <p>2013-01-01</p> <p>This study is based on original research that explored family reaction to the <span class="hlt">death</span> of an elderly husband and father. We interviewed 34 families (a family included a widow and two adult biological children) approximately 6 to 10 months after the <span class="hlt">death</span>. In one-on-one interviews, we discussed family members' initial reaction to the <span class="hlt">death</span>, how the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&pg=5&id=EJ821627','ERIC'); return false;" href="http://eric.ed.gov/?q=death&pg=5&id=EJ821627"><span id="translatedtitle"><span class="hlt">Death</span> Sentences: A Content Analysis of Children's <span class="hlt">Death</span> Literature</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Poling, Devereaux A.; Hupp, Julie M.</p> <p>2008-01-01</p> <p>A multidimensional concept of <span class="hlt">death</span> must include biological, sociocultural, and emotional components. Children glean information about <span class="hlt">death</span> in many ways, one of which is through books. In this study, the authors compared the 3 dimensions of <span class="hlt">death</span>-related information (irreversibility, inevitability, nonfunctionality) in 24 young children's picture…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16200328','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16200328"><span id="translatedtitle">Dying to be thin: attachment to <span class="hlt">death</span> in anorexia nervosa.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Latzer, Yael; Hochdorf, Zipora</p> <p>2005-09-29</p> <p>Anorexia Nervosa (AN) usually follows a prolonged course accompanied by significant morbidity and high mortality. AN patients have been found to have elevated and attempted suicide rates, with suicide being the second most common cause of <span class="hlt">death</span> in AN after the complications of the disorder itself. The suicide risk in AN is similar to that in major depression or conduct disorder and <span class="hlt">linked</span> mainly to longer duration of illness, lower weight, bingeing and purging, impulsivity-related manifestations, comorbid substance abuse, and affective disorder. This paper reviews suicidal tendency and disturbed body image, <span class="hlt">death</span> and eating disorders, and attachment and <span class="hlt">death</span> with clinical implications related to AN. PMID:16200328</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4590742','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4590742"><span id="translatedtitle">Long-Term Air Pollution Exposure and Blood Pressure in the <span class="hlt">Sister</span> Study</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Chan, Stephanie H.; Van Hee, Victor C.; Bergen, Silas; Szpiro, Adam A.; DeRoo, Lisa A.; London, Stephanie J.; Marshall, Julian D.; Sandler, Dale P.</p> <p>2015-01-01</p> <p>Background Exposure to air pollution has been consistently associated with cardiovascular morbidity and mortality, but mechanisms remain uncertain. Associations with blood pressure (BP) may help to explain the cardiovascular effects of air pollution. Objective We examined the cross-sectional relationship between long-term (annual average) residential air pollution exposure and BP in the National Institute of Environmental Health Sciences’ <span class="hlt">Sister</span> Study, a large U.S. cohort study investigating risk factors for breast cancer and other outcomes. Methods This analysis included 43,629 women 35–76 years of age, enrolled 2003–2009, who had a <span class="hlt">sister</span> with breast cancer. Geographic information systems contributed to satellite-based nitrogen dioxide (NO2) and fine particulate matter (≤ 2.5 μm; PM2.5) predictions at participant residences at study entry. Generalized additive models were used to examine the relationship between pollutants and measured BP at study entry, adjusting for cardiovascular disease risk factors and including thin plate splines for potential spatial confounding. Results A 10-μg/m3 increase in PM2.5 was associated with 1.4-mmHg higher systolic BP (95% CI: 0.6, 2.3; p < 0.001), 1.0-mmHg higher pulse pressure (95% CI: 0.4, 1.7; p = 0.001), 0.8-mmHg higher mean arterial pressure (95% CI: 0.2, 1.4; p = 0.01), and no significant association with diastolic BP. A 10-ppb increase in NO2 was associated with a 0.4-mmHg (95% CI: 0.2, 0.6; p < 0.001) higher pulse pressure. Conclusions Long-term PM2.5 and NO2 exposures were associated with higher blood pressure. On a population scale, such air pollution–related increases in blood pressure could, in part, account for the increases in cardiovascular disease morbidity and mortality seen in prior studies. Citation Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. 2015. Long-term air pollution exposure and blood pressure in the <span class="hlt">Sister</span> Study. Environ Health</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1988EOSTr..69..620.','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1988EOSTr..69..620."><span id="translatedtitle">Transatlantic <span class="hlt">link</span></span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p></p> <p></p> <p>(left) European Geophysical Society (EGS) President Rolf Meissner at AGU Headquarters with (center) Executive Director Fred Spilhaus and (right) Foreign Secretary Juan Roederer. Meissner attended the meeting of AGU's Committee on International Participation (CIP) on February 26, 1988. At that meeting, specific ways of fostering close <span class="hlt">links</span> between AGU and EGS were discussed.A few weeks later, Roederer and AGU staff, working with EGS Secretary-General Arne Richter at the EGS meeting in Bologna, Italy, March 21-25, planned details of the establishment of an AGU office in Europe. The Copernicus Gesellschaft, a new entity located on the premises of the Max Planck Institute for Aeronomy in Lindau, Federal Republic of Germany, will provide the administrative staff and handle logistics.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/magazine/issues/fall07/articles/fall07pg16-17.html','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/magazine/issues/fall07/articles/fall07pg16-17.html"><span id="translatedtitle">Life, <span class="hlt">Death</span>, and Second Chances</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Home Current Issue Past Issues Special Section Life, <span class="hlt">Death</span>, and Second Chances Past Issues / Fall 2007 Table ... New Asthma Guidelines: What You Should Know / Life, <span class="hlt">Death</span>, and Second Chances / Asthma Research: The NIH-NJRC ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nichd.nih.gov/health/topics/sids/conditioninfo/Pages/default.aspx','NIH-MEDLINEPLUS'); return false;" href="https://www.nichd.nih.gov/health/topics/sids/conditioninfo/Pages/default.aspx"><span id="translatedtitle">Sudden Infant <span class="hlt">Death</span> Syndrome (SIDS)</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Information Clinical Trials Resources and Publications Sudden Infant <span class="hlt">Death</span> Syndrome (SIDS): Condition Information Skip sharing on social ... Share this: Page Content SIDS is the sudden <span class="hlt">death</span> of an infant younger than 1 year of ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=child+AND+abuse+OR+neglect+AND+malaysia&id=EJ506682','ERIC'); return false;" href="http://eric.ed.gov/?q=child+AND+abuse+OR+neglect+AND+malaysia&id=EJ506682"><span id="translatedtitle">Childhood <span class="hlt">Deaths</span> from Physical Abuse.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Kasim, Mohd. Sham; and Others</p> <p>1995-01-01</p> <p>This paper describes 30 cases of childhood <span class="hlt">deaths</span> caused by physical abuse in Kuala Lumpur, Malaysia. Data presented include ethnic origins, age, causes of <span class="hlt">death</span>, identity of perpetrators, and marital situation of parents. (DB)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1376008','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1376008"><span id="translatedtitle"><span class="hlt">Death</span> in Denmark: a reply.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lamb, D</p> <p>1991-01-01</p> <p>This reply to Martyn Evans's support for a cardiac-centered concept of <span class="hlt">death</span> attempts to meet some objections to the brainstem definition of <span class="hlt">death</span>. Evans's appeal to Wittgenstein's philosophy is also criticised. PMID:1870081</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2627303','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2627303"><span id="translatedtitle">How should we measure maternal mortality in the developing world? A comparison of household <span class="hlt">deaths</span> and sibling history approaches.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hill, Kenneth; El Arifeen, Shams; Koenig, Michael; Al-Sabir, Ahmed; Jamil, Kanta; Raggers, Han</p> <p>2006-01-01</p> <p>OBJECTIVE: A reduction in the maternal mortality ratio (MMR) is one of six health-related Millennium Development Goals (MDGs). However, there is no consensus about how to measure MMR in the many countries that do not have complete registration of <span class="hlt">deaths</span> and accurate ascertainment of cause of <span class="hlt">death</span>. In this study, we compared estimates of pregnancy-related <span class="hlt">deaths</span> and maternal mortality in a developing country from three different household survey measurement approaches: a module collecting information on <span class="hlt">deaths</span> of respondents' <span class="hlt">sisters</span>; collection of information about recent household <span class="hlt">deaths</span> with a time-of-<span class="hlt">death</span> definition of maternal <span class="hlt">deaths</span>; and a verbal autopsy instrument to identify maternal <span class="hlt">deaths</span>. METHODS: We used data from a very large nationally-representative household sample survey conducted in Bangladesh in 2001. A total of 104 323 households were selected for participation, and 99 202 households (95.1% of selected households, 98.8% of contacted households) were successfully interviewed. FINDINGS: The sisterhood and household <span class="hlt">death</span> approaches gave very similar estimates of all-cause and pregnancy-related mortality; verbal autopsy gave an estimate of maternal <span class="hlt">deaths</span> that was about 15% lower than the pregnancy-related <span class="hlt">deaths</span>. Even with a very large sample size, however, confidence intervals around mortality estimates were similar for all approaches and exceeded +/- 15%. CONCLUSION: Our findings suggest that with improved training for survey data collectors, both the sisterhood and household <span class="hlt">deaths</span> methods are viable approaches for measuring pregnancy-related mortality. However, wide confidence intervals around the estimates indicate that routine sample surveys cannot provide the information needed to monitor progress towards the MDG target. Other approaches, such as inclusion of questions about household <span class="hlt">deaths</span> in population censuses, should be considered. PMID:16583075</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24592875','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24592875"><span id="translatedtitle">On social <span class="hlt">death</span>: ostracism and the accessibility of <span class="hlt">death</span> thoughts.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Steele, Caroline; Kidd, David C; Castano, Emanuele</p> <p>2015-01-01</p> <p>Being rejected, excluded, or simply ignored is a painful experience. Ostracism researchers have shown its powerful negative consequences (Williams, 2007), and sociologists have referred to such experiences as social <span class="hlt">death</span> (Bauman, 1992). Is this is just a metaphor or does being ostracized make <span class="hlt">death</span> more salient in people's minds? An experiment was conducted in which participants experienced ostracism or inclusion using the Cyberball manipulation, and the accessibility of <span class="hlt">death</span>-related thoughts was measured via a word-stem completion puzzle. Results showed enhanced <span class="hlt">death</span>-thought accessibility in the ostracism condition, as well as a negative effect of dispositional self-esteem on the accessibility of <span class="hlt">death</span>-related thoughts. PMID:24592875</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2761079','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2761079"><span id="translatedtitle">Risk stratification for sudden cardiac <span class="hlt">death</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Cutler, Michael J; Rosenbaum, David S.</p> <p>2009-01-01</p> <p>The proportion of cardiovascular <span class="hlt">deaths</span> attributable to sudden cardiac <span class="hlt">death</span> (SCD) is on the rise. Herein lies the rationale for developing risk stratification strategies to predict who will benefit from prophylactic ICD implantation. Current guidelines recommend prophylactic ICD therapy in patients with reduced left ventricular ejection fraction (LVEF). However, there are clear limitations in using LVEF alone to decide who should receive an ICD. There is mounting evidence that microvolt-level T wave alternans (TWA) is an important marker of arrhythmic risk. TWA is appealing because it non-invasively probes underlying electrophysiological substrate and has been <span class="hlt">linked</span> to cellular mechanisms for arrhythmias. This review considers the clinical role of TWA for risk stratification of SCD. PMID:19631909</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.er.usgs.gov/publication/70024793','USGSPUBS'); return false;" href="http://pubs.er.usgs.gov/publication/70024793"><span id="translatedtitle">Magmatic activity beneath the quiescent Three <span class="hlt">Sisters</span> volcanic center, central Oregon Cascade Range, USA</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Wicks, Charles W., Jr.; Dzurisin, Daniel; Ingebritsen, Steven E.; Thatcher, Wayne R.; Lu, Zhong; Iverson, Justin</p> <p>2002-01-01</p> <p>Images from satellite interferometric synthetic aperture radar (InSAR) reveal uplift of a broad ???10 km by 20 km area in the Three <span class="hlt">Sisters</span> volcanic center of the central Oregon Cascade Range, ???130 km south of Mt. St. Helens. The last eruption in the volcanic center occurred ???1500 years ago. Multiple satellite images from 1992 through 2000 indicate that most if not all of ???100 mm of observed uplift occurred between September 1998 and October 2000. Geochemical (water chemistry) anomalies, first noted during 1990, coincide with the area of uplift and suggest the existence of a crustal magma reservoir prior to the uplift. We interpret the uplift as inflation caused by an ongoing episode of magma intrusion at a depth of ???6.5 km.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27185886','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27185886"><span id="translatedtitle">Bromodeoxyuridine does not contribute to <span class="hlt">sister</span> chromatid exchange events in normal or Bloom syndrome cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>van Wietmarschen, Niek; Lansdorp, Peter M</p> <p>2016-08-19</p> <p><span class="hlt">Sister</span> chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that SCEs are induced by DNA replication over BrdU-substituted DNA and that BrdU incorporation alone could be responsible for the high number of SCE events observed in cells from patients with Bloom syndrome (BS), a rare genetic disorder characterized by marked genome instability and high SCE frequency. Here we show using Strand-seq, a single cell DNA template strand sequencing technique, that the presence of variable BrdU concentrations in the cell culture medium and in DNA template strands has no effect on SCE frequency in either normal or BS cells. We conclude that BrdU does not induce SCEs and that SCEs detected in either normal or BS cells reflect DNA repair events that occur spontaneously. PMID:27185886</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1035328','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1035328"><span id="translatedtitle">Frequency of <span class="hlt">sister</span> chromatid exchange and chromosomal aberrations in asbestos cement workers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fatma, N; Jain, A K; Rahman, Q</p> <p>1991-01-01</p> <p>Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. It was shown previously that asbestos samples collected from a local asbestos factory enhanced <span class="hlt">sister</span> chromatid exchanges (SCEs) and chromosomal aberrations in vitro using human lymphocytes. In the present study, 22 workers from the same factory and 12 controls were further investigated. Controls were matched for age, sex, and socioeconomic state. The peripheral blood lymphocytes were cultured and harvested at 48 hours for studies of chromosomal aberrations and at 72 hours for SCE frequency determinations. Asbestos workers had a raised mean SCE rate and increased numbers of chromosomal aberrations compared with a control population. Most of the chromosomal aberrations were chromatid gap and break types. PMID:1998603</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/1998603','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/1998603"><span id="translatedtitle">Frequency of <span class="hlt">sister</span> chromatid exchange and chromosomal aberrations in asbestos cement workers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fatma, N; Jain, A K; Rahman, Q</p> <p>1991-02-01</p> <p>Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. It was shown previously that asbestos samples collected from a local asbestos factory enhanced <span class="hlt">sister</span> chromatid exchanges (SCEs) and chromosomal aberrations in vitro using human lymphocytes. In the present study, 22 workers from the same factory and 12 controls were further investigated. Controls were matched for age, sex, and socioeconomic state. The peripheral blood lymphocytes were cultured and harvested at 48 hours for studies of chromosomal aberrations and at 72 hours for SCE frequency determinations. Asbestos workers had a raised mean SCE rate and increased numbers of chromosomal aberrations compared with a control population. Most of the chromosomal aberrations were chromatid gap and break types. PMID:1998603</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/18955506','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/18955506"><span id="translatedtitle">My <span class="hlt">sister</span>, myself: a culture- and gender-based approach to HIV/AIDS prevention.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shambley-Ebron, Donna Z</p> <p>2009-01-01</p> <p>African American women are bearing an excess burden of HIV/AIDS, becoming infected at a rate 25 times that of White American women. This places African American girls at the highest risk for becoming infected with HIV/AIDS. Culturally appropriate prevention strategies are indicated to suppress this trend. Two qualitative research methods were used to evaluate a culture- and gender-based HIV prevention intervention: My <span class="hlt">Sister</span>, Myself. Community action participatory research was used to engage the community in the development of the intervention for early-adolescent girls. Eight girls participated in the 8-week intervention. Data were collected about culture and gender identification, sexual health knowledge, and future intentions throughout the intervention. Focus groups and observation participation data revealed three major themes: "high aspirations," "needing to know the truth," and "internal, external, and eternal resources." Findings indicate promise for intervention strategies that utilize culture- and gender-based strategies for HIV/AIDS prevention with young girls. PMID:18955506</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980104','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4980104"><span id="translatedtitle">Genomic analysis reveals hidden biodiversity within colugos, the <span class="hlt">sister</span> group to primates</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Mason, Victor C.; Li, Gang; Minx, Patrick; Schmitz, Jürgen; Churakov, Gennady; Doronina, Liliya; Melin, Amanda D.; Dominy, Nathaniel J.; Lim, Norman T-L.; Springer, Mark S.; Wilson, Richard K.; Warren, Wesley C.; Helgen, Kristofer M.; Murphy, William J.</p> <p>2016-01-01</p> <p>Colugos are among the most poorly studied mammals despite their centrality to resolving supraordinal primate relationships. Two described species of these gliding mammals are the sole living members of the order Dermoptera, distributed throughout Southeast Asia. We generated a draft genome sequence for a Sunda colugo and a Philippine colugo reference alignment, and used these to identify colugo-specific genetic changes that were enriched in sensory and musculoskeletal-related genes that likely underlie their nocturnal and gliding adaptations. Phylogenomic analysis and catalogs of rare genomic changes overwhelmingly support the contested hypothesis that colugos are the <span class="hlt">sister</span> group to primates (Primatomorpha), to the exclusion of treeshrews. We captured ~140 kb of orthologous sequence data from colugo museum specimens sampled across their range and identified large genetic differences between many geographically isolated populations that may result in a >300% increase in the number of recognized colugo species. Our results identify conservation units to mitigate future losses of this enigmatic mammalian order. PMID:27532052</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783675','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1783675"><span id="translatedtitle">Roles of the <span class="hlt">sister</span> chromatid cohesion apparatus in gene expression, development, and human syndromes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dorsett, Dale</p> <p>2006-01-01</p> <p>The <span class="hlt">sister</span> chromatid cohesion apparatus mediates physical pairing of duplicated chromosomes. This pairing is essential for appropriate distribution of chromosomes into the daughter cells upon cell division. Recent evidence shows that the cohesion apparatus, which is a significant structural component of chromosomes during interphase, also affects gene expression and development. The Cornelia de Lange (CdLS) and Roberts/SC phocomelia (RBS/SC) genetic syndromes in humans are caused by mutations affecting components of the cohesion apparatus. Studies in Drosophila suggest that effects on gene expression are most likely responsible for developmental alterations in CdLS. Effects on chromatid cohesion are apparent in RBS/SC syndrome, but data from yeast and Drosophila point to the likelihood that changes in expression of genes located in heterochromatin could contribute to the developmental deficits. PMID:16819604</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26917595','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26917595"><span id="translatedtitle">Mouse oocytes differentiate through organelle enrichment from <span class="hlt">sister</span> cyst germ cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lei, Lei; Spradling, Allan C</p> <p>2016-04-01</p> <p>Oocytes differentiate in diverse species by receiving organelles and cytoplasm from <span class="hlt">sister</span> germ cells while joined in germline cysts or syncytia. Mouse primordial germ cells form germline cysts, but the role of cysts in oogenesis is unknown. We find that mouse germ cells receive organelles from neighboring cyst cells and build a Balbiani body to become oocytes, whereas nurselike germ cells die. Organelle movement, Balbiani body formation, and oocyte fate determination are selectively blocked by low levels of microtubule-dependent transport inhibitors. Membrane breakdown within the cyst and an apoptosis-like process are associated with organelle transfer into the oocyte, events reminiscent of nurse cell dumping in Drosophila We propose that cytoplasmic and organelle transport plays an evolutionarily conserved and functionally important role in mammalian oocyte differentiation. PMID:26917595</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519633','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3519633"><span id="translatedtitle">Incestuous <span class="hlt">Sisters</span>: Mate Preference for Brothers over Unrelated Males in Drosophila melanogaster</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Loyau, Adeline; Cornuau, Jérémie H.; Clobert, Jean; Danchin, Étienne</p> <p>2012-01-01</p> <p>The literature is full of examples of inbreeding avoidance, while recent mathematical models predict that inbreeding tolerance or even inbreeding preference should be expected under several realistic conditions like e.g. polygyny. We investigated male and female mate preferences with respect to relatedness in the fruit fly D. melanogaster. Experiments offered the choice between a first order relative (full-sibling or parent) and an unrelated individual with the same age and mating history. We found that females significantly preferred mating with their brothers, thus supporting inbreeding preference. Moreover, females did not avoid mating with their fathers, and males did not avoid mating with their <span class="hlt">sisters</span>, thus supporting inbreeding tolerance. Our experiments therefore add empirical evidence for inbreeding preference, which strengthens the prediction that inbreeding tolerance and preference can evolve under specific circumstances through the positive effects on inclusive fitness. PMID:23251487</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3296444','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3296444"><span id="translatedtitle">Squamous Cell Carcinoma Arising in a Testicular Teratoma and Presenting as <span class="hlt">Sister</span> Mary Joseph Nodule</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Khan, Kalyan; Bagchi, Dibakar</p> <p>2011-01-01</p> <p>The most common somatic type malignancy arising in patients with testicular germ cell tumors (GCTs) is sarcoma. Development of carcinomas, especially squamous cell carcinoma is an extremely rare event. Most cases of metastatic umbilical nodules (<span class="hlt">Sister</span> Mary Joseph nodule) develop from adenocarcinomas. Fifteen percent of such cases have unknown origin; but development from a testicular squamous cell carcinoma has not yet been reported in the literature. We report a rare case of somatic type squamous cell carcinoma arising in a testicular teratoma. It is also possibly the first reported case of its kind which presented with a metastatic umbilical nodule. This possibility should be kept in mind while evaluating metastatic umbilical nodules in young male patients. PMID:22413055</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3872193','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3872193"><span id="translatedtitle">Chromosome Segregation in Budding Yeast: <span class="hlt">Sister</span> Chromatid Cohesion and Related Mechanisms</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>Studies on budding yeast have exposed the highly conserved mechanisms by which duplicated chromosomes are evenly distributed to daughter cells at the metaphase–anaphase transition. The establishment of proteinaceous bridges between <span class="hlt">sister</span> chromatids, a function provided by a ring-shaped complex known as cohesin, is central to accurate segregation. It is the destruction of this cohesin that triggers the segregation of chromosomes following their proper attachment to microtubules. Since it is irreversible, this process must be tightly controlled and driven to completion. Furthermore, during meiosis, modifications must be put in place to allow the segregation of maternal and paternal chromosomes in the first division for gamete formation. Here, I review the pioneering work from budding yeast that has led to a molecular understanding of the establishment and destruction of cohesion. PMID:24395824</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27532052','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27532052"><span id="translatedtitle">Genomic analysis reveals hidden biodiversity within colugos, the <span class="hlt">sister</span> group to primates.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mason, Victor C; Li, Gang; Minx, Patrick; Schmitz, Jürgen; Churakov, Gennady; Doronina, Liliya; Melin, Amanda D; Dominy, Nathaniel J; Lim, Norman T-L; Springer, Mark S; Wilson, Richard K; Warren, Wesley C; Helgen, Kristofer M; Murphy, William J</p> <p>2016-08-01</p> <p>Colugos are among the most poorly studied mammals despite their centrality to resolving supraordinal primate relationships. Two described species of these gliding mammals are the sole living members of the order Dermoptera, distributed throughout Southeast Asia. We generated a draft genome sequence for a Sunda colugo and a Philippine colugo reference alignment, and used these to identify colugo-specific genetic changes that were enriched in sensory and musculoskeletal-related genes that likely underlie their nocturnal and gliding adaptations. Phylogenomic analysis and catalogs of rare genomic changes overwhelmingly support the contested hypothesis that colugos are the <span class="hlt">sister</span> group to primates (Primatomorpha), to the exclusion of treeshrews. We captured ~140 kb of orthologous sequence data from colugo museum specimens sampled across their range and identified large genetic differences between many geographically isolated populations that may result in a >300% increase in the number of recognized colugo species. Our results identify conservation units to mitigate future losses of this enigmatic mammalian order. PMID:27532052</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4436877','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4436877"><span id="translatedtitle">Thymineless <span class="hlt">death</span>, at the origin</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Guzmán, Elena C.; Martín, Carmen M.</p> <p>2015-01-01</p> <p>Thymineless <span class="hlt">death</span> (TLD) in bacteria has been a focus of research for decades. Nevertheless, the advances in the last 5 years, with Escherichia coli as the model organism, have been outstanding. Independent research groups have presented compelling results that establish that the initiation of chromosome replication under thymine starvation is a key element in the scenario of TLD. Here we review the experimental results <span class="hlt">linking</span> the initiation of replication to the lethality under thymine starvation and the proposed mechanisms by which TLD occurs. The concept of this relationship was ‘in the air,’ but approaches were not sufficiently developed to demonstrate the crucial role of DNA initiation in TLD. Genome-wide marker frequency analysis and Two Dimensional agarose gel electrophoresis have been critical methods employed to reveal that initiation events and the degradation of the oriC region occur during thymine starvation. The relationships between these events and TLD have established them to be the main underlying causes of the lethality under thymine starvation. Furthermore, we summarize additional important findings from the study of different mutant strains, which support the idea that the initiation of chromosomal replication and TLD are connected. PMID:26042116</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27376998','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27376998"><span id="translatedtitle"><span class="hlt">Deaths</span>: Leading Causes for 2014.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Heron, Melonie</p> <p>2016-06-01</p> <p>Objectives-This report presents final 2014 data on the 10 leading causes of <span class="hlt">death</span> in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal <span class="hlt">death</span> are also presented. This report supplements "<span class="hlt">Deaths</span>: Final Data for 2014," the National Center for Health Statistics' annual report of final mortality statistics. PMID:27376998</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.compassionatefriends.org/brochures/death_of_an_adult_child.aspx','NIH-MEDLINEPLUS'); return false;" href="http://www.compassionatefriends.org/brochures/death_of_an_adult_child.aspx"><span id="translatedtitle"><span class="hlt">Death</span> of an Adult Child</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... iGive.com Purchase Through AmazonSmile Contact Us Donate <span class="hlt">Death</span> of an Adult Child The <span class="hlt">death</span> of any child, regardless of cause or age, ... the situations that may have caused their child’s <span class="hlt">death</span>. Judgmental statements from others indicating that the child ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED270785.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED270785.pdf"><span id="translatedtitle"><span class="hlt">Death</span>: Realism in Children's Books.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Danielson, Kathy Everts</p> <p></p> <p>In the past, books for children treated <span class="hlt">death</span> fearfully, morbidly, and didactically, but now children's literature treats <span class="hlt">death</span> in a more realistic manner and is sensitive to its emotional aspects. Current theories suggest that children perceive <span class="hlt">death</span> differently at various ages. G. P. Koocher (1973) used J. Piaget's cognitive stages as the basis…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED443928.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED443928.pdf"><span id="translatedtitle"><span class="hlt">Deaths</span>: Final Data for 1998.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Murphy, Sherry L.</p> <p>2000-01-01</p> <p>This report presents final 1998 data on U.S. <span class="hlt">deaths</span> and <span class="hlt">death</span> rates according to demographic and medical characteristics such as age, sex, race, Hispanic origin, marital status, educational attainment, injury at work, state of residence, and cause of <span class="hlt">death</span>. Trends and patterns in general mortality, life expectancy, and infant and maternal…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Brittany&pg=2&id=EJ358873','ERIC'); return false;" href="http://eric.ed.gov/?q=Brittany&pg=2&id=EJ358873"><span id="translatedtitle">Changing Breton Responses to <span class="hlt">Death</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Badone, Ellen</p> <p>1988-01-01</p> <p>Based on fieldwork conducted in Brittany, France, during 1983 and 1984, discusses changes in Breton responses to <span class="hlt">death</span> which have accompanied modernization and economic development. Suggests that familiarity with <span class="hlt">death</span> and acceptance of it are being replaced by the "denial of <span class="hlt">death</span>" characteristic of contemporary Western culture. Notes parallel…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=euthanasia&pg=7&id=ED166116','ERIC'); return false;" href="http://eric.ed.gov/?q=euthanasia&pg=7&id=ED166116"><span id="translatedtitle">Teaching about <span class="hlt">Death</span> to Undergraduates.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Pine, Vanderlyn R.; And Others</p> <p></p> <p>Development, implementation, and teaching of a college-level course on dying and <span class="hlt">death</span> are described. The authors review their own experiences in becoming involved with <span class="hlt">death</span> education and describe teaching methods, problems, and content of their current course in dying and <span class="hlt">death</span> at the State University of New York, College at New Paltz. Because…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7993309','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7993309"><span id="translatedtitle">Educational and occupational achievements of brothers and <span class="hlt">sisters</span> in adoptive and biologically related families.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Scarr, S; Weinberg, R A</p> <p>1994-07-01</p> <p>The study of brothers and <span class="hlt">sisters</span> from adoptive and biologically related families permits unique analyses of the determinants of young adults' educational and occupational achievements. Brothers and <span class="hlt">sisters</span> come from the same homes, neighborhoods, and usually schools. Many differences among families are controlled by the study of siblings. In addition, adoptive families influence their children only through the environment they provide, whereas biologically related parents transmit their intellectual and personal characteristics to their offspring genetically as well. Thus, the comparison of models of adult achievements for children from adoptive and biologically related families can inform us about the true effects of family environments, apart from genetic transmission (Scarr and Weinberg, 1978, 1980). In this follow-up study of 450 biologically related and adopted young adults (ages 22 to 30 years), we report on the family resemblances in educational and occupational achievements. Parents' reports were obtained on 97% of the original sample (N = 443), and 77% of the young adults participated in the follow-up study themselves; complete educational and occupational data were available on 303 young adults. Results show that biological sons are more influenced by their family backgrounds than daughters, regardless of genetic relatedness. A second finding is that young women's achievements are not as predictable from their own earlier achievements as are those of their brothers. A third finding is that parents invest in their sons' educational futures, regardless of sons' abilities and achievements, in ways they do not invest in their daughters' postsecondary educations. Sibling correlations and natural mother-adopted child correlations suggest that test scores, high school performance, postsecondary education, and even later occupational status can be influenced by genetic variability in personal characteristics that affect such achievements. PMID:7993309</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25360249','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25360249"><span id="translatedtitle">Wider sampling reveals a non-<span class="hlt">sister</span> relationship for geographically contiguous lineages of a marine mussel.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Cunha, Regina L; Nicastro, Katy R; Costa, Joana; McQuaid, Christopher D; Serrão, Ester A; Zardi, Gerardo I</p> <p>2014-06-01</p> <p>The accuracy of phylogenetic inference can be significantly improved by the addition of more taxa and by increasing the spatial coverage of sampling. In previous studies, the brown mussel Perna perna showed a <span class="hlt">sister</span>-lineage relationship between eastern and western individuals contiguously distributed along the South African coastline. We used mitochondrial (COI) and nuclear (ITS) sequence data to further analyze phylogeographic patterns within P. perna. Significant expansion of the geographical coverage revealed an unexpected pattern. The western South African lineage shared the most recent common ancestor (MRCA) with specimens from Angola, Venezuela, and Namibia, whereas eastern South African specimens and Mozambique grouped together, indicating a non-<span class="hlt">sister</span> relationship for the two South African lineages. Two plausible biogeographic scenarios to explain their origin were both supported by the hypotheses-testing analysis. One includes an Indo-Pacific origin for P. perna, dispersal into the Mediterranean and Atlantic through the Tethys seaway, followed by recent secondary contact after southward expansion of the western and eastern South African lineages. The other scenario (Out of South Africa) suggests an ancient vicariant divergence of the two lineages followed by their northward expansion. Nevertheless, the "Out of South Africa" hypothesis would require a more ancient divergence between the two lineages. Instead, our estimates indicated that they diverged very recently (310 kyr), providing a better support for an Indo-Pacific origin of the two South African lineages. The arrival of the MRCA of P. perna in Brazil was estimated at 10 [0-40] kyr. Thus, the hypothesis of a recent introduction in Brazil through hull fouling in wooden vessels involved in the transatlantic itineraries of the slave trade did not receive strong support, but given the range for this estimate, it could not be discarded. Wider geographic sampling of marine organisms shows that lineages</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17305857','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17305857"><span id="translatedtitle">Evolutionary relationships of Drosophila mojavensis geographic host races and their <span class="hlt">sister</span> species Drosophila arizonae.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reed, L K; Nyboer, M; Markow, T A</p> <p>2007-03-01</p> <p>The cactophilic Drosophila mojavensis species group living in the deserts and dry tropical forests of the southwestern United States and Mexico provides a valuable system for studies in diversification and speciation. Rigorous studies of the relationships between host races of D. mojavensis and the relationships among the members of the species group (D. mojavensis, Drosophila arizona, and Drosophila navojoa) are lacking. We used mitochondrial CO1 sequence data to address the phylogenetics and population genetics of this species group. In this study we have found that the <span class="hlt">sister</span> species D. mojavensis and D. arizonae share no mitochondrial haplotypes and thus show no evidence for recent introgression. We estimate the divergence time between D. mojavensis and D. arizonae to be between 1.91 and 2.97 million years ago. D. arizonae shows little structure in our population genetic analyses but there is phylogenetic differentiation between southeastern and northern populations of D. arizonae. Drosophila mojavensis shows significant population and phylogenetic structure across the four geographic regions of its distribution. The mitochondrial data support an origin of D. mojavensis on the mainland with early differentiation into the populations now found in the Mojave Desert and the Mainland Sonoran Desert and later colonization of the Baja Peninsula, in contrast to previous models. Also, the <span class="hlt">sister</span> clade to D. mojavensis/D. arizonae includes D. navojoa and Drosophila huaylasi. By defining the genetic relationships among these populations, we provide a foundation for more sophisticated hypothesis testing regarding the timing of early speciation events and host switches in this species group. PMID:17305857</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/978251','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/978251"><span id="translatedtitle">An increase in telomere <span class="hlt">sister</span> chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Wang, Yisong; Giannone, Richard J; Wu, Jun; Gomez, Marla V; Liu, Yie</p> <p>2005-01-01</p> <p>Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells during prolonged growth in culture. Rare survivors can maintain telomere length through either activation of telomerase or recombination-based telomere lengthening, and thus proliferate indefinitely. We have explored the possibility that telomeres may be maintained through telomere <span class="hlt">sister</span> chromatid exchange (T-SCE) in murine telomere reverse transcriptase-deficient (mTert -/-) splenocytes and ES cells. Because telomerase deficiency leads to gradual loss of telomeric DNA in mTert -/- splenocytes and ES cells and eventually to chromosomes with telomere signal-free ends (SFEs), we examined these cell types for evidence of <span class="hlt">sister</span> chromatid exchange at telomeres, and observed an increase in T-SCEs only in a subset of mTert -/- splenocytes or ES cells that possessed multiple SFEs. Furthermore, T-SCEs were more often detected in ES cells than in splenocytes that harbored a similar frequency of SFEs. In mTert heterozygous (mTert +/-) ES cells or splenocytes, which are known to exhibit a decrease in average telomere length but no SFEs, no increase in T-SCE was observed. In addition to T-SCE, other genomic rearrangements (i.e., SCE) were also significantly increased in mTert -/- ES cells possessing critically short telomeres, but not in splenocytes. Our results suggest that animals and cell culture differ in their ability to carry out genomic rearrangements as a means of maintaining telomere integrity when telomeres become critically shortened.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26012953','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26012953"><span id="translatedtitle">Effects of infliximab on <span class="hlt">sister</span> chromatid exchanges and chromosomal aberration in patients with rheumatoid arthritis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Atteritano, M; Mazzaferro, S; Mantuano, S; Bagnato, G L; Bagnato, G F</p> <p>2016-03-01</p> <p>The aim of this study was to evaluate in a 24-weeks the effect of anti-TNF-alpha, infliximab, on cytogenetic biomarkers in peripheral lymphocytes of patients with rheumatoid arthritis (RA). A total of 40 patients with RA met the criteria to be treated with methotrexate (15 mg/week) were evaluated. Twenty patients, randomly selected, were treated with infliximab in addition to methotrexate (group I), whereas the other 20 patients continued with only methotrexate treatment (group M). Twenty healthy volunteers matched for age, gender and smoking habits served as control group (group C). At baseline, <span class="hlt">sister</span> chromatid exchange rate was 7.20 ± 2.21 in group I, 7.40 ± 1.60 in group M and 4.97 ± 1.32 in group C (P < 0.01 vs group I and M). After 24-weeks, <span class="hlt">sister</span> chromatid exchange rate was 7.87 ± 2.54 in group I and 7.81 ± 1.95 in group M (P = ns). High frequency cells count was 4.9 % and 4.7 % in the groups I and M, respectively, at the end of the study (P = ns). The basal chromosomal aberration frequency was 4.90 % in group I and 5.20 % in groups M; after 24-weeks, this was 5.10 % in group I and 5.10 % in groups M (P = ns). Infliximab treatment, for 24 weeks, did not increase the cytogenetic biomarkers in patients with RA. Our data show that the use of infliximab has not a genotoxic effect in patients with RA. PMID:26012953</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3473239','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3473239"><span id="translatedtitle">Phylogenomic analyses support the position of turtles as the <span class="hlt">sister</span> group of birds and crocodiles (Archosauria)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2012-01-01</p> <p>Background The morphological peculiarities of turtles have, for a long time, impeded their accurate placement in the phylogeny of amniotes. Molecular data used to address this major evolutionary question have so far been limited to a handful of markers and/or taxa. These studies have supported conflicting topologies, positioning turtles as either the <span class="hlt">sister</span> group to all other reptiles, to lepidosaurs (tuatara, lizards and snakes), to archosaurs (birds and crocodiles), or to crocodilians. Genome-scale data have been shown to be useful in resolving other debated phylogenies, but no such adequate dataset is yet available for amniotes. Results In this study, we used next-generation sequencing to obtain seven new transcriptomes from the blood, liver, or jaws of four turtles, a caiman, a lizard, and a lungfish. We used a phylogenomic dataset based on 248 nuclear genes (187,026 nucleotide sites) for 16 vertebrate taxa to resolve the origins of turtles. Maximum likelihood and Bayesian concatenation analyses and species tree approaches performed under the most realistic models of the nucleotide and amino acid substitution processes unambiguously support turtles as a <span class="hlt">sister</span> group to birds and crocodiles. The use of more simplistic models of nucleotide substitution for both concatenation and species tree reconstruction methods leads to the artefactual grouping of turtles and crocodiles, most likely because of substitution saturation at third codon positions. Relaxed molecular clock methods estimate the divergence between turtles and archosaurs around 255 million years ago. The most recent common ancestor of living turtles, corresponding to the split between Pleurodira and Cryptodira, is estimated to have occurred around 157 million years ago, in the Upper Jurassic period. This is a more recent estimate than previously reported, and questions the interpretation of controversial Lower Jurassic fossils as being part of the extant turtles radiation. Conclusions These results</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6353622','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6353622"><span id="translatedtitle">Magnesium and sudden <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Leary, W P; Reyes, A J</p> <p>1983-10-22</p> <p>Magnesium deficiency may result from reduced dietary intake of the ion or increased losses in sweat, urine or faeces. Stress potentiates magnesium deficiency, and an increased incidence of sudden <span class="hlt">death</span> associated with ischaemic heart disease is found in some areas in which soil and drinking water lack magnesium. Furthermore, it has been demonstrated experimentally that reduction of the plasma magnesium level is associated with arterial spasm. Careful studies are required to assess the clinical importance of magnesium and the benefits of magnesium supplementation in man. PMID:6353622</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1633498','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1633498"><span id="translatedtitle"><span class="hlt">Death</span> after Taking Medicaments</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Girdwood, R. H.</p> <p>1974-01-01</p> <p>A register of reported adverse reactions, recently made available to major hospitals and medical schools gives an indication of prescribing habits under the N.H.S. in England and Wales. An analysis is made here of the chief medicaments allegedly leading to <span class="hlt">death</span>. Such data are incomplete because of lack of knowledge of the total use of each drug in the United Kingdom and because reporting of adverse reactions is very incomplete. Nevertheless, data about various groups of drugs do draw attention to some hazards and should encourage more widespread reporting of reactions to drugs and other medicaments. PMID:4817164</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1502884','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1502884"><span id="translatedtitle">Anesthetic Complications and <span class="hlt">Deaths</span></span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Pender, John W.</p> <p>1968-01-01</p> <p>Anesthesiologists should fully inform patients of the possible complications from anesthesia. For rapport with the patient, with whom they usually have no acquaintance until a day or so before an operative procedure, the anesthesiologist should enlist the help of the internist or surgeon who already has established an atmosphere of trust. The extent of morbidity and minor complications from anesthesia has not been adequately recorded. One out of every 1,000 to 2,000 anesthetized patients dies of complications primarily due to or contributed to by anesthesia. Leading causes of <span class="hlt">death</span> vary from study to study and from year to year. PMID:5652756</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=death&pg=7&id=EJ721468','ERIC'); return false;" href="http://eric.ed.gov/?q=death&pg=7&id=EJ721468"><span id="translatedtitle">Happiness and <span class="hlt">Death</span> Distress: Two Separate Factors</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Abdel-Khalek, Ahmed M.</p> <p>2005-01-01</p> <p>The aim of the present study was to explore the relationship between happiness and <span class="hlt">death</span> distress (<span class="hlt">death</span> anxiety, <span class="hlt">death</span> depression, and <span class="hlt">death</span> obsession) in 275 volunteer Kuwaiti undergraduates. They responded to the Oxford Happiness Inventory, the <span class="hlt">Death</span> Anxiety Scale, the Arabic Scale of <span class="hlt">Death</span> Anxiety, the <span class="hlt">Death</span> Depression Scale-Revised, and the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=size+AND+dependent+AND+variable&pg=3&id=EJ825688','ERIC'); return false;" href="http://eric.ed.gov/?q=size+AND+dependent+AND+variable&pg=3&id=EJ825688"><span id="translatedtitle">Dietary Behaviors and Portion Sizes of Black Women Who Enrolled in "<span class="hlt">Sister</span>Talk" and Variation by Demographic Characteristics</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Gans, Kim M.; Risica, Patricia Markham; Kirtania, Usree; Jennings, Alishia; Strolla, Leslie O.; Steiner-Asiedu, Matilda; Hardy, Norma; Lasater, Thomas M.</p> <p>2009-01-01</p> <p>Objective: To describe the dietary behaviors of black women who enrolled in the <span class="hlt">Sister</span>Talk weight control study. Design: Baseline data collected via telephone survey and in-person screening. Setting: Boston, Massachusetts and surrounding areas. Participants: 461 black women completed the baseline assessments. Main Outcome Measures: Measured height…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24119410','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24119410"><span id="translatedtitle">The <span class="hlt">sister</span>-group relationships of the largest family of lichenized fungi, Parmeliaceae (Lecanorales, Ascomycota).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Singh, Garima; Divakar, Pradeep K; Dal Grande, Francesco; Otte, Jürgen; Parnmen, Sittiporn; Wedin, Mats; Crespo, Ana; Lumbsch, H Thorsten; Schmitt, Imke</p> <p>2013-10-01</p> <p>Parmeliaceae is the largest family of lichen-forming fungi. In spite of its importance for fungal diversity, its relationships with other families in Lecanorales remain poorly known. To better understand the evolutionary history of the diversification of lineages and species richness in Parmeliaceae it is important to know the phylogenetic relationships of the closest relatives of the family. A recent study based on two molecular loci suggested that either Protoparmelia s. str. or a group consisting of Gypsoplaca and Protoparmelia s. str. were the possible <span class="hlt">sister</span>-group candidates of Parmeliaceae, but that study could not distinguish between these two alternatives. Here, we used a four-locus phylogeny (nuLSU, ITS, RPB1, MCM7) to reveal relationships of Parmeliaceae with other potential relatives in Lecanorales. Maximum likelihood and Bayesian analyses showed that Protoparmelia is polyphyletic, with Protoparmelia s. str. (including Protoparmelia badia and Protoparmelia picea) being most closely related to Parmeliaceae s. str., while the Protoparmelia atriseda-group formed the <span class="hlt">sister</span>-group to Miriquidica. Gypsoplaca formed the <span class="hlt">sister</span>-group to the Parmeliaceae s. str. + Protoparmelia s. str. clade. Monophyly of Protoparmelia as currently circumscribed, and Gypsoplaca as <span class="hlt">sister</span>-group to Parmeliaceae s. str. were both significantly rejected by alternative hypothesis testing. PMID:24119410</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=eggs&pg=7&id=EJ698372','ERIC'); return false;" href="http://eric.ed.gov/?q=eggs&pg=7&id=EJ698372"><span id="translatedtitle">A Gift from the Heart: The Experiences of Women Whose Egg Donations Helped Their <span class="hlt">Sisters</span> Become Mothers.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Winter, Alanna; Daniluk, Judith C.</p> <p>2004-01-01</p> <p>During in-depth interviews, 3 women whose egg donations resulted in the birth of a child or children for their <span class="hlt">sisters</span> discussed their donation motivations and decisions, the challenges of the donation procedure, and their postdonation feelings and experiences in the years since the birth of their nieces and nephews. The findings of this narrative…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-08-15/pdf/2012-20067.pdf"><span id="translatedtitle">77 FR 48993 - Proposed Collection; Comment Request; The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic and...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-08-15</p> <p>... Environmental Risk Factors for Breast Cancer SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A... Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer. Type of Information... breast cancer in a high-risk cohort of <span class="hlt">sisters</span> of women who have had breast cancer. The etiology...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-11-07/pdf/2012-27237.pdf"><span id="translatedtitle">77 FR 66851 - Submission for OMB Review; Comment Request The <span class="hlt">Sister</span> Study: A Prospective Study of the Genetic...</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-11-07</p> <p>...: A Prospective Study of the Genetic and Environmental Risk Factors for Breast Cancer SUMMARY: Under... Breast Cancer. Type of Information Collection Request: Revision. Need and Use of Information Collection... risk factors for the development of breast cancer in a high-risk cohort of <span class="hlt">sisters</span> of women who...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25728689','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25728689"><span id="translatedtitle">Does breastfeeding behavior run in families? Evidence from twins, their <span class="hlt">sisters</span> and their mothers in the Netherlands.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Merjonen, Päivi; Dolan, Conor V; Bartels, Meike; Boomsma, Dorret I</p> <p>2015-04-01</p> <p>The aim of the present article was to study the prevalence and the heritability of the initiation of breastfeeding in the Netherlands. The study was carried out in 5,581 participants from the Netherlands Twin Register, and included female twins, their <span class="hlt">sisters</span> and mothers. All of the participants were born between 1911 and 1991. Breastfeeding was self-reported by the participants, and its prevalence was estimated conditional on birth cohort (born before 1955, 1955-1964, 1965-1974, 1975, or later). To estimate the heritability, we conducted extended twin-family modeling using the SEM package OpenMx in R. Mothers of twins had lower prevalence to initiate breastfeeding and the prevalence of initiation of breastfeeding increased with birth cohort: among mothers of twins 66% in the oldest (pre-1955) to 74% in the youngest (post-1974) and among mothers, who were twins themselves or <span class="hlt">sisters</span> of twins, 79% in the oldest (pre-1955) to 85% in the youngest (post-1974). When accounting for prevalence differences between mothers of twins and other women, heritability of initiation of breastfeeding was 70%. However, the familial resemblance for <span class="hlt">sister</span> and mother-daughter pairs was clearly lower than for DZ twin pairs, but as the number of non-twin <span class="hlt">sisters</span> was relatively low, this observation did not lead to a significant contribution of a special shared twin environment. PMID:25728689</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED513452.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED513452.pdf"><span id="translatedtitle">Untapped Potential: Fulfilling the Promise of Big Brothers Big <span class="hlt">Sisters</span> and the Bigs and Littles They Represent</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Bridgeland, John M.; Moore, Laura A.</p> <p>2010-01-01</p> <p>American children represent a great untapped potential in our country. For many young people, choices are limited and the goal of a productive adulthood is a remote one. This report paints a picture of who these children are, shares their insights and reflections about the barriers they face, and offers ways forward for Big Brothers Big <span class="hlt">Sisters</span> as…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4244149','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4244149"><span id="translatedtitle">Using Ecological Niche Models and Niche Analyses to Understand Speciation Patterns: The Case of <span class="hlt">Sister</span> Neotropical Orchid Bees</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Silva, Daniel P.; Vilela, Bruno; De Marco, Paulo; Nemésio, André</p> <p>2014-01-01</p> <p>The role of past connections between the two major South American forested biomes on current species distribution has been recognized a long time ago. Climatic oscillations that further separated these biomes have promoted parapatric speciation, in which many species had their continuous distribution split, giving rise to different but related species (i.e., different potential distributions and realized niche features). The distribution of many <span class="hlt">sister</span> species of orchid bees follow this pattern. Here, using ecological niche models and niche analyses, we (1) tested the role of ecological niche differentiation on the divergence between <span class="hlt">sister</span> orchid-bees (genera Eulaema and Eufriesea) from the Amazon and Atlantic forests, and (2) highlighted interesting areas for new surveys. Amazonian species occupied different realized niches than their Atlantic <span class="hlt">sister</span> species. Conversely, species of sympatric but distantly related Eulaema bees occupied similar realized niches. Amazonian species had a wide potential distribution in South America, whereas Atlantic Forest species were more limited to the eastern coast of the continent. Additionally, we identified several areas in need of future surveys. Our results show that the realized niche of Atlantic-Amazonian <span class="hlt">sister</span> species of orchid bees, which have been previously treated as allopatric populations of three species, had limited niche overlap and similarity. These findings agree with their current taxonomy, which treats each of those populations as distinct valid species. PMID:25422941</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3424243','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3424243"><span id="translatedtitle">LAB-1 Targets PP1 and Restricts Aurora B Kinase upon Entrance into Meiosis to Promote <span class="hlt">Sister</span> Chromatid Cohesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Tzur, Yonatan B.; Egydio de Carvalho, Carlos; Nadarajan, Saravanapriah; Van Bostelen, Ivo; Gu, Yanjie; Chu, Diana S.; Cheeseman, Iain M.; Colaiácovo, Monica P.</p> <p>2012-01-01</p> <p>Successful execution of the meiotic program depends on the timely establishment and removal of <span class="hlt">sister</span> chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase I in C. elegans, yet the mechanism and scope of LAB-1 function remained unknown. Here we identify an unexpected earlier role for LAB-1 in promoting the establishment of <span class="hlt">sister</span> chromatid cohesion in prophase I. LAB-1 and REC-8 are both required for the chromosomal association of the cohesin complex subunit SMC-3. Depletion of lab-1 results in partial loss of <span class="hlt">sister</span> chromatid cohesion in rec-8 and coh-4 coh-3 mutants and further enhanced chromatid dissociation in worms where all three kleisins are mutated. Moreover, lab-1 depletion results in increased Aurora B kinase (AIR-2) signals in early prophase I nuclei, coupled with a parallel decrease in signals for the PP1 homolog, GSP-2. Finally, LAB-1 directly interacts with GSP-1 and GSP-2. We propose that LAB-1 targets the PP1 homologs to the chromatin at the onset of meiosis I, thereby antagonizing AIR-2 and cooperating with the cohesin complex to promote <span class="hlt">sister</span> chromatid association and normal progression of the meiotic program. PMID:22927794</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=49473&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=49473&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677"><span id="translatedtitle">KINETICS OF IN VIVO <span class="hlt">SISTER</span> CHROMATID EXCHANGE INDUCTION IN MOUSE BONE MARROW CELLS BY ALKYLATING AGENTS: CYCLOPHOSPHAMIDE</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Administration of cyclophosphamide (5, 10, 20 and 25 mg/kg body weight) to male CD-1 mice 2 hours after subcutaneous implantation of a 5-bromo-2'-deoxyuridine (BrdU) pellet (55 mg) resulted in a dose-dependent increase in <span class="hlt">sister</span> chromatid exchanges (SCE) in bone marrow cells. Tre...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4931922','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4931922"><span id="translatedtitle">Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of <span class="hlt">sister</span> telomeres</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>McKerlie, Megan; Zhu, Xu-Dong</p> <p>2016-01-01</p> <p>Cyclin B-Cdk1 is a key mediator of mitotic entry, however little is known about its role in the separation of <span class="hlt">sister</span> chromatids. Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding protein implicated in the regulation of <span class="hlt">sister</span> telomere cohesion. Such phosphorylation is removed in late mitosis when Cdk1 activity is inhibited, indicative of a tight regulation of T371 phosphorylation. We show that T371 phosphorylation by Cdk1 keeps TRF1 free of chromatin and this phosphorylation is associated with loss of telomere-bound TRF1 and TIN2, and a reduction in telomere heterochromatin. We find that a phosphomimic mutation at T371 of TRF1 induces telomere deprotection, resulting in telomere loss and the formation of telomere fusions whereas a non-phosphorylatable substitution of T371 blocks <span class="hlt">sister</span> telomere resolution, promotes micronuclei formation and impairs cell proliferation. Our work suggests that Cdk1 controls TRF1 association with telomeres to facilitate temporal telomere de-protection essential for <span class="hlt">sister</span> telomere resolution. PMID:21712819</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=241184','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=241184"><span id="translatedtitle">Phylogenetic analysis of seven WRKY genes across the palm subtribe Attaleinae (Areceaceae) identifies Syagrus as <span class="hlt">sister</span> to the coconut</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>The origins of the coconut (Cocos nucifera) have been one of the "abominable mysteries" of palm systematics for decades. Previous studies with predominantly plastid genes have indicated an American ancestry for the coconut but with weak support and ambiguous <span class="hlt">sister</span> relationships. We used primers d...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=luks&id=EJ451212','ERIC'); return false;" href="http://eric.ed.gov/?q=luks&id=EJ451212"><span id="translatedtitle">An Evaluation of Parental Assessment of the Big Brothers/Big <span class="hlt">Sisters</span> Program in New York City.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Frecknall, Peter; Luks, Alan</p> <p>1992-01-01</p> <p>Parents rated impact of Big Brother/Big <span class="hlt">Sister</span> program on children along variables of school attendance, grades, family relationship, friendship, self-esteem, staying out of trouble, being responsible, frequency of contact, and length of time in program. Although children were rated as benefiting significantly from program, children's frequency of…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=big&pg=5&id=ED503112','ERIC'); return false;" href="http://eric.ed.gov/?q=big&pg=5&id=ED503112"><span id="translatedtitle">High School Students as Mentors: Findings from the Big Brothers Big <span class="hlt">Sisters</span> School-Based Mentoring Impact Study</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Herrera, Carla; Kauh, Tina J.; Cooney, Siobhan M.; Grossman, Jean Baldwin; McMaken, Jennifer</p> <p>2008-01-01</p> <p>High schools have recently become a popular source of mentors for school-based mentoring (SBM) programs. The high school Bigs program of Big Brothers Big <span class="hlt">Sisters</span> of America, for example, currently involves close to 50,000 high-school-aged mentors across the country. While the use of these young mentors has several potential advantages, their age…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=7&id=EJ772803','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=7&id=EJ772803"><span id="translatedtitle">Scaling the Heights of Heaven: <span class="hlt">Sister</span> M. Rosalia Walsh and the Use of Story in "The Adaptive Way"</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Nolan, Lucinda A.</p> <p>2007-01-01</p> <p>The work of <span class="hlt">Sister</span> M. Rosalia Walsh and the Mission Helpers of the Sacred Heart gave impetus to the reemergence of the use of story in catechetical materials designed and published in the United States during the first half of the twentieth century. Focused on catechetical needs of Catholic children who did not attend Catholic schools, The Mission…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=7&id=ED523978','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=7&id=ED523978"><span id="translatedtitle">The Discernment Process of the <span class="hlt">Sisters</span> of Saint Dominic regarding the Continued Sponsorship of Its Secondary Schools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tavis, Patricia</p> <p>2010-01-01</p> <p>The purpose of this dissertation was to examine the factors that a congregation of women religious, the <span class="hlt">Sisters</span> of Saint Dominic of Caldwell, New Jersey, must consider in order to continue its sponsored relationship and the extent of this sponsored relationship with its secondary educational ministries for the future. This descriptive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=349649','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=349649"><span id="translatedtitle">Cultured mouse embryos metabolize benzo[a]pyrene during early gestation: genetic differences detectable by <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Galloway, S M; Perry, P E; Meneses, J; Nebert, D W; Pedersen, R A</p> <p>1980-01-01</p> <p>Mouse embryos explanted at 7 1/2 or 8 1/2 days of gestation were cultured in medium containing benzo[a]pyrene and supplemented with 5-bromodeoxyuridine to allow detection of <span class="hlt">sister</span> chromatid exchanges. The murine Ah locus regulates the inducible metabolism of polycyclic hydrocarbons such as benzo[a]pyrene. A high frequency of <span class="hlt">sister</span> chromatid exchange was induced by benzo[a]pyrene in embryos from three Ah-"responsive" inbred strains (BALB/cDub, C3H/AnfCum, and C57BL/6N); there was little or no increase in two Ah-"nonresponsive" inbred strains (AKR/J and DBA/2J). Benzo[a]pyrene also induced <span class="hlt">sister</span> chromatid exchanges in the Ah-responsive recombinant inbred line B6NXAKN-12 but not in the Ah-nonresponsive recombinant inbred line B6NXAKN-3. <span class="hlt">Sister</span> chromatid exchange in cultured Ah-responsive mouse embryos was thus shown to be a sensitive assay. These data provide direct evidence that genetically responsive mouse embryos (early postimplantation stage) possess the subcellular processes necessary for induction of enzymes that metabolize benzo[a]pyrene to its chemically active forms(s). Both the Ah regulatory gene product (a cytoslic receptor) and the structural gene product (inducible cytochrome P1-450) therefore appear to be functional at an early embryonic age. Furthermore, this metabolic capacity may play an important role in the damage to embryonic cells by polycyclic hydracarbons. PMID:6932035</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/news/fullstory_158317.html','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/news/fullstory_158317.html"><span id="translatedtitle">Study <span class="hlt">Links</span> Green Spaces to Longer Lives for Women</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... gov/medlineplus/news/fullstory_158317.html Study <span class="hlt">Links</span> Green Spaces to Longer Lives for Women Among the ... risk of <span class="hlt">death</span> than those in the least green locations. The study also found that women with ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26034855','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26034855"><span id="translatedtitle">Sudden infant <span class="hlt">death</span> syndrome.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Adams, Stephen M; Ward, Chad E; Garcia, Karla L</p> <p>2015-06-01</p> <p>Sudden infant <span class="hlt">death</span> syndrome (SIDS) is the sudden unexpected <span class="hlt">death</span> of a child younger than one year during sleep that cannot be explained after a postmortem evaluation including autopsy, a thorough history, and scene evaluation. The incidence of SIDS has decreased more than 50% in the past 20 years, largely as a result of the Back to Sleep campaign. The most important risk factors relate to the sleep environment. Prone and side sleeping positions are significantly more dangerous than the supine position. Bed sharing with a parent is strongly correlated with an increased risk of SIDS, especially in infants younger than 12 weeks. Apparent life-threatening events are not a risk factor for SIDS. Parents should place infants on their backs to sleep, should not share a bed, and should avoid exposing the infant to tobacco smoke. Other risk-reducing measures include using a firm crib mattress, breastfeeding, keeping vaccinations up to date, avoiding overheating due to overbundling, avoiding soft bedding, and considering the use of a pacifier during sleep once breastfeeding is established. One consequence of the Back to Sleep campaign is a significant increase in the incidence of occipital flattening. Infants who develop a flat spot should be placed with the head facing alternating directions each time he or she is put to bed. Supervised prone positioning while the infant is awake, avoiding excessive use of carriers, and upright positioning while awake are also recommended. PMID:26034855</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007SPIE.6427E..02K&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007SPIE.6427E..02K&link_type=ABSTRACT"><span id="translatedtitle">PDT: <span class="hlt">death</span> pathways</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Kessel, David</p> <p>2007-02-01</p> <p>Cellular targets of photodynamic therapy include mitochondria, lysosomes, the endoplasmic reticulum (ER) and the plasma membrane. PDT can evoke necrosis, autophagy and apoptosis, or combinations of these, depending on the PDT dose, the site(s) of photodamage and the cellular phenotype. It has been established that loss of viability occurs even when the apoptotic program is inhibited. Studies assessing effects of ER or mitochondrial photodamage, involving loss of Bcl-2 function, indicate that low-dose PDT elicited a rapid autophagic response in L1210 cells. This was attributed to the ability of autophagy to recycle photodamaged organelles, and there was partial protection from loss of viability. This effect was not observed in L1210/Atg7, where autophagy was silenced. At higher PDT doses, apoptotic cells were observed within 60 min in both cell lines, but more so in L1210. The ability of L1210 cells to undergo autophagy did not offer protection from cell <span class="hlt">death</span> at the higher PDT dose. Previous studies had indicated that autophagy can contribute to cell <span class="hlt">death</span>, since L1210 cells that do not undergo an initial apoptotic response often contain multiple autophagic vacuoles 24 hr later. With L1210/Atg7, apoptosis alone may account for the loss of viability at an LD 90 PDT dose.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1475900','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1475900"><span id="translatedtitle">Sudden infant <span class="hlt">death</span> syndrome</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Hunt, Carl E.; Hauck, Fern R.</p> <p>2006-01-01</p> <p>Sudden infant <span class="hlt">death</span> syndrome (SIDS) continues to be the most common cause of postneonatal infant <span class="hlt">death</span>. SIDS is a complex, multifactorial disorder, the cause of which is still not fully understood. However, much is known now about environmental risk factors, some of which are modifiable. These include maternal and antenatal risk factors such as smoking during pregnancy, as well as infant-related risk factors such as non-supine sleeping position and soft bedding. Emerging evidence also substantiates an expanding number of genetic risk factors. Interactions between environmental and genetic risk factors may be of critical importance in determining an infant's actual risk of SIDS. Although no practical way exists to identify which infants will die of SIDS, nor is there a safe and proven prevention strategy even if identification were feasible, reducing exposure to modifiable risk factors has helped to lower the incidence of SIDS. Current challenges include wider dissemination of guidelines to all people who care for infants, dissemination of guidelines in culturally appropriate ways, and surveillance of SIDS trends and other outcomes associated with implementation of these guidelines. PMID:16785462</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24926440','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24926440"><span id="translatedtitle">Stressing mitosis to <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Burgess, Andrew; Rasouli, Mina; Rogers, Samuel</p> <p>2014-01-01</p> <p>The final stage of cell division (mitosis), involves the compaction of the duplicated genome into chromatid pairs. Each pair is captured by microtubules emanating from opposite spindle poles, aligned at the metaphase plate, and then faithfully segregated to form two identical daughter cells. Chromatids that are not correctly attached to the spindle are detected by the constitutively active spindle assembly checkpoint (SAC). Any stress that prevents correct bipolar spindle attachment, blocks the satisfaction of the SAC, and induces a prolonged mitotic arrest, providing the cell time to obtain attachment and complete segregation correctly. Unfortunately, during mitosis repairing damage is not generally possible due to the compaction of DNA into chromosomes, and subsequent suppression of gene transcription and translation. Therefore, in the presence of significant damage cell <span class="hlt">death</span> is instigated to ensure that genomic stability is maintained. While most stresses lead to an arrest in mitosis, some promote premature mitotic exit, allowing cells to bypass mitotic cell <span class="hlt">death</span>. This mini-review will focus on the effects and outcomes that common stresses have on mitosis, and how this impacts on the efficacy of mitotic chemotherapies. PMID:24926440</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/12512174','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/12512174"><span id="translatedtitle">Definitions and implications of <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schlotzhauer, Anna V; Liang, Bryan A</p> <p>2002-12-01</p> <p>Understanding the legal definition of whole-brain <span class="hlt">death</span> is imperative for hematologists and oncologists who deal with end-of-life patients on a regular basis. At present, only whole-brain <span class="hlt">death</span> in which there is no function of the upper brain or brain stem is legally recognized as legal <span class="hlt">death</span>. Those advocating expansion of the current definition of <span class="hlt">death</span> to encompass patients with higher brain <span class="hlt">death</span> and brain-absent anencephalic infants cite increasing the organ pool and decreasing unnecessary treatment and costs as benefits. Those advocating a more narrow definition of <span class="hlt">death</span> typically fear being misdiagnosed or prefer the traditional cardiopulmonary definition for personal and religious reasons. As medical technology advances, offering new hope to both the critically injured patients who might be potential donors and to those patients in need of donated organs, the definition of <span class="hlt">death</span> will continue to be a topic of passionate debate. PMID:12512174</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26475683','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26475683"><span id="translatedtitle">Speciation processes in putative island endemic <span class="hlt">sister</span> bat species: false impressions from mitochondrial DNA and microsatellite data.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kuo, Hao-Chih; Chen, Shiang-Fan; Fang, Yin-Ping; Cotton, James A; Parker, Joe D; Csorba, Gábor; Lim, Burton K; Eger, Judith L; Chen, Chia-Hong; Chou, Cheng-Han; Rossiter, Stephen J</p> <p>2015-12-01</p> <p>Cases of geographically restricted co-occurring <span class="hlt">sister</span> taxa are rare and may point to potential divergence with gene flow. The two bat species Murina gracilis and Murina recondita are both endemic to Taiwan and are putative <span class="hlt">sister</span> species. To test for nonallopatric divergence and gene flow in these taxa, we generated sequences using Sanger and next-generation sequencing, and combined these with microsatellite data for coalescent-based analyses. MtDNA phylogenies supported the reciprocally monophyletic <span class="hlt">sister</span> relationship between M. gracilis and M. recondita; however, clustering of microsatellite genotypes revealed several cases of species admixture suggesting possible introgression. Sequencing of microsatellite flanking regions revealed that admixture signatures stemmed from microsatellite allele homoplasy rather than recent introgressive hybridization, and also uncovered an unexpected <span class="hlt">sister</span> relationship between M. recondita and the continental species Murina eleryi, to the exclusion of M. gracilis. To dissect the basis of these conflicts between ncDNA and mtDNA, we analysed sequences from 10 anonymous ncDNA loci with *beast and isolation-with-migration and found two distinct clades of M. eleryi, one of which was <span class="hlt">sister</span> to M. recondita. We conclude that Taiwan was colonized by the ancestor of M. gracilis first, followed by the ancestor of M. recondita after a period of allopatric divergence. After colonization, the mitochondrial genome of M. recondita was replaced by that of the resident M. gracilis. This study illustrates how apparent signatures of sympatric divergence can arise from complex histories of allopatric divergence, colonization and hybridization, thus highlighting the need for rigorous analyses to distinguish between such scenarios. PMID:26475683</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/3684869','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/3684869"><span id="translatedtitle">Behavior of chickens prior to <span class="hlt">death</span> from sudden <span class="hlt">death</span> syndrome.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Newberry, R C; Gardiner, E E; Hunt, J R</p> <p>1987-09-01</p> <p>A study was made to determine if chickens dying from sudden <span class="hlt">death</span> syndrome (SDS) showed any unusual behavioral characteristics during the final 12 h preceding <span class="hlt">death</span>. Continuous video recordings were made of floor pens of 50 to 120 individually marked male broiler chickens between 3 and 10 wk of age. Behavioral data were obtained from video tapes played back following <span class="hlt">death</span> of chickens from SDS. Analysis of the video tapes revealed no significant differences between 10 SDS chickens and their matched controls in the frequencies or proportions of time spent in each of 19 different behavioral activities. All SDS chickens exhibited a sudden attack prior to <span class="hlt">death</span> lasting an average of 53 s and characterized by loss of balance, violent flapping, and strong muscular contractions. There was no evidence that <span class="hlt">death</span> was preceded by a particular environmental or behavioral event. It was concluded that there were no consistent behavioral symptoms which could be used to identify SDS chickens prior to <span class="hlt">death</span>. PMID:3684869</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=STS059%28S%29026&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Ds','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=STS059%28S%29026&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D80%26Ntt%3Ds"><span id="translatedtitle"><span class="hlt">Death</span> Valley, California</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p></p> <p>1994-01-01</p> <p>This is an image of <span class="hlt">Death</span> Valley, California, centered at 36.629 degrees north latitude, 117.069 degrees west longitude. The image shows Furnace Creek alluvial fan and Furnace Creek Ranch at the far right, and the sand dunes near Stove Pipe Wells at the center. The dark fork-shaped feature between Furnace Creek fan and the dunes is a smooth flood-plain which encloses Cottonball Basin. The bright dots near the center of the image are corner refectors that have been set-up to calibrate the radar as the Shuttle passes overhead with the SIR-C/X-SAR system. The Jet Propulsion Laboratory alternative photo number is P-43883.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6584755','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6584755"><span id="translatedtitle"><span class="hlt">Deaths</span> from electricity.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Brokenshire, B; Cairns, F J; Koelmeyer, T D; Smeeton, W M; Tie, A B</p> <p>1984-03-14</p> <p>This paper reviews the circumstances of 95 fatalities from electrical injuries. Eighty-nine were accidental, four were suicides and two occurred during autoerotic electrical stimulation. Forty-nine of the accidental fatalities occurred at work, Twenty-eight in the home and twelve in the course of outside recreational activities. In many accidents the circumstances were distressingly similar and included: (1) Contact with overhead distribution lines by a length of conductor such as a yacht mast or crane. (2) Faulty wiring or electrical repairs performed by unqualified people. (3) Badly deteriorated cords, plugs and occasionally appliances. (4) Failure to use isolating transformers when indicated. <span class="hlt">Deaths</span> involving children are a particular cause of concern. Nine fatalites involved children under the age of five years who contacted inadequately protected wires. PMID:6584755</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4928029','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4928029"><span id="translatedtitle">Phenotypic heterogeneity in females with X-<span class="hlt">linked</span> Alport syndrome</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Allred, Samuel C.; Weck, Karen E.; Gasim, Adil; Mottl, Amy K.</p> <p>2015-01-01</p> <p>Aims: X-<span class="hlt">linked</span> Alport syndrome (AS) is a monogenic inherited disorder of type IV collagen, a structural protein in the kidney and cochlea. Males typically exhibit a severe phenotype with end-stage renal disease (ESRD) and/or deafness by early adulthood. Because of the presence of two X chromosomes, females often have a less severe phenotype and hence the diagnosis of AS is often not considered. Herein, we present a case of an adolescent girl with proteinuria and hematuria in the setting of a strong family history of AL. Case report: The mother and maternal aunt of the proband had both presented with dipstick positive hematuria and proteinuria at age 8 years. These girls were not evaluated by nephrology until mid-adolescence when they had worsening creatinine levels. Kidney biopsy in the younger <span class="hlt">sister</span> demonstrated segmental glomerulosclerosis with segmental thinning and lamination of the glomerular basement membrane, consistent with AS. Kidney biopsy in the older <span class="hlt">sister</span> was performed just prior to the need for renal replacement therapy and showed only global glomerulosclerosis. Both <span class="hlt">sisters</span> were transplanted by the age of 20 years. Their mother subsequently developed ESRD at age 53 years. With the advent of genetic testing, the proband and her family were brought in for evaluation. It had been assumed this family of AS had autosomal dominant transmission, however, genetic testing of the proband was positive for a splice site mutation of COL4A5 located on the X-chromosome. Sequencing of genes COL4A3, COL4A4, and COL4A6 were negative for mutation. Conclusions: The current case report demonstrates the importance of considering skewed X-inactivation in females who exhibit signs or symptoms of X-<span class="hlt">linked</span> disorders. PMID:26249550</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/ency/article/002050.htm','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/ency/article/002050.htm"><span id="translatedtitle">Sex-<span class="hlt">linked</span> dominant</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Inheritance - sex-<span class="hlt">linked</span> dominant; Genetics - sex-<span class="hlt">linked</span> dominant; X-<span class="hlt">linked</span> dominant; Y-<span class="hlt">linked</span> dominant ... one of the sex chromosomes, which are the X and Y chromosomes. Dominant inheritance occurs when an ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/ency/article/002051.htm','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/ency/article/002051.htm"><span id="translatedtitle">Sex-<span class="hlt">linked</span> recessive</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Inheritance - sex-<span class="hlt">linked</span> recessive; Genetics - sex-<span class="hlt">linked</span> recessive; X-<span class="hlt">linked</span> recessive ... X-<span class="hlt">linked</span> recessive diseases usually occur in males. Males have only one X chromosome. A single recessive ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/ency/article/002050.htm','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/ency/article/002050.htm"><span id="translatedtitle">Sex-<span class="hlt">linked</span> dominant</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>Inheritance - sex-<span class="hlt">linked</span> dominant; Genetics - sex-<span class="hlt">linked</span> dominant; X-<span class="hlt">linked</span> dominant; Y-<span class="hlt">linked</span> dominant ... type of chromosome that is affected (autosomal or sex chromosome). It also depends on whether the trait ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26114245','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26114245"><span id="translatedtitle">The Role of <span class="hlt">Sister</span> Cities' Staff Exchanges in Developing "Learning Cities": Exploring Necessary and Sufficient Conditions in Social Capital Development Utilizing Proportional Odds Modeling.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy</p> <p>2015-07-01</p> <p>In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building "learning cities" through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal <span class="hlt">sister</span> city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit <span class="hlt">Link</span> approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met. PMID:26114245</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101564','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3101564"><span id="translatedtitle">A <span class="hlt">Sister</span> Group Contrast Using Untargeted Global Metabolomic Analysis Delineates the Biochemical Regulation Underlying Desiccation Tolerance in Sporobolus stapfianus[C][W][OA</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Oliver, Melvin J.; Guo, Lining; Alexander, Danny C.; Ryals, John A.; Wone, Bernard W.M.; Cushman, John C.</p> <p>2011-01-01</p> <p>Understanding how plants tolerate dehydration is a prerequisite for developing novel strategies for improving drought tolerance. The desiccation-tolerant (DT) Sporobolus stapfianus and the desiccation-sensitive (DS) Sporobolus pyramidalis formed a <span class="hlt">sister</span> group contrast to reveal adaptive metabolic responses to dehydration using untargeted global metabolomic analysis. Young leaves from both grasses at full hydration or at 60% relative water content (RWC) and from S. stapfianus at lower RWCs were analyzed using liquid and gas chromatography <span class="hlt">linked</span> to mass spectrometry or tandem mass spectrometry. Comparison of the two species in the fully hydrated state revealed intrinsic differences between the two metabolomes. S. stapfianus had higher concentrations of osmolytes, lower concentrations of metabolites associated with energy metabolism, and higher concentrations of nitrogen metabolites, suggesting that it is primed metabolically for dehydration stress. Further reduction of the leaf RWC to 60% instigated a metabolic shift in S. stapfianus toward the production of protective compounds, whereas S. pyramidalis responded differently. The metabolomes of S. stapfianus leaves below 40% RWC were strongly directed toward antioxidant production, nitrogen remobilization, ammonia detoxification, and soluble sugar production. Collectively, the metabolic profiles obtained uncovered a cascade of biochemical regulation strategies critical to the survival of S. stapfianus under desiccation. PMID:21467579</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16882688','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16882688"><span id="translatedtitle">centrosomin's beautiful <span class="hlt">sister</span> (cbs) encodes a GRIP-domain protein that marks Golgi inheritance and functions in the centrosome cycle in Drosophila.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Eisman, Robert C; Stewart, Natasha; Miller, David; Kaufman, Thomas C</p> <p>2006-08-15</p> <p>The mechanism of inheritance of the Golgi complex is an important problem in cell biology. In this study, we examine the localization and function of a Golgi protein encoded by centrosomin's beautiful <span class="hlt">sister</span> (cbs) during cleavage in Drosophila melanogaster. Cbs contains a GRIP domain that is 57% identical to vertebrate Golgin-97. Cbs undergoes a dramatic relocalization during mitosis from the cytoplasm to an association with chromosomes from late prometaphase to early telophase, by a transport mechanism that requires the GRIP domain and Arl1, the product of the Arf72A locus. Additionally, Cbs remains independent of the endoplasmic reticulum throughout cleavage. The use of RNAi, Arf72A mutant analysis and ectopic expression of the GRIP domain, shows that cycling of Cbs during mitosis is required for the centrosome cycle. The effects on the centrosome cycle depend on Cbs concentration and Cbs transport from the cytoplasm to DNA. When Cbs levels are reduced centrosomes fail to mature, and when Cbs transport is impeded by ectopic expression of the GRIP domain, centrosomes undergo hypertrophy. We propose that, Cbs is a trans-Golgi protein that <span class="hlt">links</span> Golgi inheritance to the cell cycle and the Drosophila Golgi is more vertebrate-like than previously recognized. PMID:16882688</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4515646','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4515646"><span id="translatedtitle">The Role of <span class="hlt">Sister</span> Cities’ Staff Exchanges in Developing “Learning Cities”: Exploring Necessary and Sufficient Conditions in Social Capital Development Utilizing Proportional Odds Modeling</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy</p> <p>2015-01-01</p> <p>In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building “learning cities” through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal <span class="hlt">sister</span> city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit <span class="hlt">Link</span> approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met. PMID:26114245</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5276942','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5276942"><span id="translatedtitle">Effect of oral administration of mutagens found in food on the frequency of <span class="hlt">sister</span> chromatid exchanges in the colonic epithelium of mice</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Couch, D.B.; Stuart, E.; Heddle, J.A.</p> <p>1987-01-01</p> <p>Epidemiological studies indicate there is a <span class="hlt">link</span> between dietary factors and the incidence of colon cancer, and it has been suggested mutagens in foods might be responsible for initiating the carcinogenic process. Some food mutagens are formed during the cooking process. For example, certain heterocyclic amines, including Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-n) indole) and MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoline), which have been isolated from broiled meat and fish at low (ng/g) levels, are extremely potent mutagens in the Ames Salmonella/microsome test and can induce mutation in cultured mammalian cells as well. Other mutagens in foods are natural products; quercetin, a flavanoid widely distributed in plant products, is mutagenic to Salmonella and cultured mammalian cells. As most of the evidence implicating substance in food as mutagenic carcinogens comes from in vitro studies, it is of interest to determine whether these compounds can also exert genotoxic effects in vivo, particularly in colonic tissue. The ability to induce nuclear aberrations in vivo in murine colonic epithelial tissue has been suggested to be a property of colon carcinogens specifically, and several mutagens found in cooked food, including MeIQ and Trp-P-2, have been found to produce such nucleotoxicity. The authors report here tests of the ability of MeIQ, Trp-P-2, and quercetin to induce <span class="hlt">sister</span> chromatid exchanges (SCEs) in the colonic epithelium of mice.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21432870','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21432870"><span id="translatedtitle">A primatological perspective on <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Anderson, James R</p> <p>2011-05-01</p> <p>Some questions that arise from observations of responses to dead and dying individuals by nonhuman primates are discussed, focusing on psychological issues. The phenomenon of transport and care of dead infants is reviewed, along with the consequences of the mother dying for orphaned offspring. It is argued that particular attention should be paid to how the context of a <span class="hlt">death</span> affects individuals, for example, traumatic accidental or predation-induced <span class="hlt">death</span> versus peaceful <span class="hlt">death</span> following illness. Some primates kill others of their own or other species, which raises additional questions about <span class="hlt">death</span> awareness and empathy. Observations from both the field and captivity can contribute toward a better understanding of the psychological meaning of <span class="hlt">death</span> for primates. Some aspects of <span class="hlt">death</span> awareness recognized by developmental psychologists might help guide research efforts in this area. PMID:21432870</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21940640','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21940640"><span id="translatedtitle">Testing hypotheses about the <span class="hlt">sister</span> group of the passeriformes using an independent 30-locus data set.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Wang, Ning; Braun, Edward L; Kimball, Rebecca T</p> <p>2012-02-01</p> <p>Although many phylogenetic studies have focused on developing hypotheses about relationships, advances in data collection and computation have increased the feasibility of collecting large independent data sets to rigorously test controversial hypotheses or carefully assess artifacts that may be misleading. One such relationship in need of independent evaluation is the position of Passeriformes (perching birds) in avian phylogeny. This order comprises more than half of all extant birds, and it includes one of the most important avian model systems (the zebra finch). Recent large-scale studies using morphology, mitochondrial, and nuclear sequence data have generated very different hypotheses about the <span class="hlt">sister</span> group of Passeriformes, and all conflict with an older hypothesis generated using DNA-DNA hybridization. We used novel data from 30 nuclear loci, primarily introns, for 28 taxa to evaluate five major a priori hypotheses regarding the phylogenetic position of Passeriformes. Although previous studies have suggested that nuclear introns are ideal for the resolution of ancient avian relationships, introns have also been criticized because of the potential for alignment ambiguities and the loss of signal due to saturation. To examine these issues, we generated multiple alignments using several alignment programs, varying alignment parameters, and using guide trees that reflected the different a priori hypotheses. Although different alignments and analyses yielded slightly different results, our analyses excluded all but one of the five a priori hypotheses. In many cases, the passerines were <span class="hlt">sister</span> to the Psittaciformes (parrots), and taxa were members of a larger clade that includes Falconidae (falcons) and Cariamidae (seriemas). However, the position of Coliiformes (mousebirds) was highly unstable in our analyses of 30 loci, and this represented the primary source of incongruence among analyses. Mousebirds were united with passerines or parrots in some analyses</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27031208','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27031208"><span id="translatedtitle">[Periodic Repolarization Dynamics--innovative strategies for preventing sudden <span class="hlt">death</span>].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rizas, Konstantinos; Bauer, Axel</p> <p>2016-04-01</p> <p>Sudden cardiac <span class="hlt">death</span> (SCD) is the most common single cause of <span class="hlt">death</span> in the industrialized world. Survivors of acute myocardial infarction (MI) are at increased risk of <span class="hlt">death</span>. The vast majority of <span class="hlt">deaths</span> occur in post-MI patients with preserved left ventricular ejection fraction (LVEF) for whom no prophylactic strategies exist. Periodic repolarization dynamics (PRD) is a novel electrocardiographic phenomenon that refers to low frequency (< 0.1 Hz) modulations of cardiac repolarization, most likely <span class="hlt">linked</span> to sympathetic activity. Increased PRD is a strong and independent predictor of mortality after acute MI. PRD assessment allows to identify a new high risk group of post-MI patients with preserved LVEF (35-50 %) who have the same mortality risk as patients with LVEF ≤ 35 %. Future studies are needed to test the efficacy of preventive strategies in this new high risk group. PMID:27031208</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26820284','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26820284"><span id="translatedtitle">An approach to iatrogenic <span class="hlt">deaths</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McGuire, Angela R; DeJoseph, Maura E; Gill, James R</p> <p>2016-03-01</p> <p>Iatrogenic <span class="hlt">deaths</span> are a concern for patients, physicians, and public health specialists. Most medicolegal investigation jurisdictions in the United States have the legal authority and mandate to investigate <span class="hlt">deaths</span> associated with diagnostic/therapeutic procedures. Given the decreasing trends of autopsies performed in U.S. hospitals, forensic pathologists are likely to take on an even greater role in investigating these <span class="hlt">deaths</span>. This is an overview and forensic pathological approach to fatal complications due to diagnostic and therapeutic medical events. PMID:26820284</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1052595','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1052595"><span id="translatedtitle">Birthday and date of <span class="hlt">death</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Angermeyer, M C; Kühn, L; Osterwald, P</p> <p>1987-01-01</p> <p>The relation between birthday and date of <span class="hlt">death</span> has so far been studied from two different perspectives: birthdays were either conceived of as emotionally invested deadlines motivating people to ward off their <span class="hlt">death</span> which causes a 'dip' in <span class="hlt">death</span> rates before their birthday, or they were considered as stressful events leading to an increase of mortality on or after their birthday. Using a collection of biographies of famous people from the whole world and another of well-known Swiss citizens we tested hypotheses derived from these assumptions. Neither the '<span class="hlt">death</span>-dip' hypotheses nor the 'birthday stress' hypothesis was supported by our results. PMID:3655631</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24018251','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24018251"><span id="translatedtitle">[Genetics of sudden unexplained <span class="hlt">death</span>].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Campuzano, Oscar; Allegue, Catarina; Brugada, Ramon</p> <p>2014-03-20</p> <p>Sudden unexplained <span class="hlt">death</span> is defined by <span class="hlt">death</span> without a conclusive diagnosis after autopsy and it is responsible for a large percentage of sudden <span class="hlt">deaths</span>. The progressive interaction between genetics and forensics in post-mortem studies has identified inheritable alterations responsible for pathologies associated with arrhythmic sudden <span class="hlt">death</span>. The genetic diagnosis of the deceased enables the undertaking of preventive measures in family members, many of them asymptomatic but at risk. The implications of this multidisciplinary translational medical approach are complex, requiring the dedication of a specialized team. PMID:24018251</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/8028487','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/8028487"><span id="translatedtitle"><span class="hlt">Deaths</span> of amateur scuba divers.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Obafunwa, J O; Busuttil, A; Purdue, B</p> <p>1994-04-01</p> <p>Four scuba diving <span class="hlt">deaths</span> investigated by the Forensic Medicine Unit, University of Edinburgh Medical School, are reported. The pathological investigation of such <span class="hlt">deaths</span> requires that a detailed history of the events prior to <span class="hlt">death</span> is obtained and that the site of the accident is fully examined with underwater photographic recording where possible. The diving suits, breathing apparatus and other diving accessories also have to be examined carefully by experts and a complete autopsy with toxicological and histological examination is essential. The causes and mechanisms of <span class="hlt">death</span> are discussed, as are the importance of special autopsy techniques and investigations. Possible interpretative problems are highlighted. PMID:8028487</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7546520','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7546520"><span id="translatedtitle">"<span class="hlt">Death</span>-telling" research project.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McQuay, J E; Schwartz, R; Goldblatt, P C; Giangrasso, V M</p> <p>1995-09-01</p> <p>An unexpected <span class="hlt">death</span> is a traumatic event for everyone affected by it, especially family members. The manner in which a family is told that a <span class="hlt">death</span> has occurred has a profound effect on their grief and bereavement process. The task of the health care professional working with these patients and their families is to assist their healing by being skilled in the "<span class="hlt">death</span>-telling" process. This article focuses on the project that developed a teaching tool and videotape used to educate individuals about the proper way to inform families of the <span class="hlt">death</span> of a loved one. PMID:7546520</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=omega+AND+3&pg=4&id=EJ357802','ERIC'); return false;" href="http://eric.ed.gov/?q=omega+AND+3&pg=4&id=EJ357802"><span id="translatedtitle"><span class="hlt">Death</span> Attitudes among Mid-Life Women.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Richardson, Virginia; Sands, Roberta</p> <p>1987-01-01</p> <p>Examined <span class="hlt">death</span> attitudes among 74 female college reentry students aged 30 through 49. Found relationships between: (1) developmental factors and <span class="hlt">death</span> concern, <span class="hlt">death</span> as interpersonal loss, and <span class="hlt">death</span> as dimension of time; (2) age and <span class="hlt">death</span> anticipation; and (3) income and <span class="hlt">death</span> denial. Results suggest importance of considering both developmental…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24930367','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24930367"><span id="translatedtitle">History of brain <span class="hlt">death</span> as <span class="hlt">death</span>: 1968 to the present.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>De Georgia, Michael A</p> <p>2014-08-01</p> <p>The concept of brain <span class="hlt">death</span> was formulated in 1968 in the landmark report A Definition of Irreversible Coma. While brain <span class="hlt">death</span> has been widely accepted as a determination of <span class="hlt">death</span> throughout the world, many of the controversies that surround it have not been settled. Some may be rooted in a misconstruction about the history of brain <span class="hlt">death</span>. The concept evolved as a result of the convergence of several parallel developments in the second half of the 20th century including advances in resuscitation and critical care, research into the underlying physiology of consciousness, and growing concerns about technology, medical futility, and the ethics of end of life care. Organ transplantation also developed in parallel, and though it clearly benefited from a new definition of <span class="hlt">death</span>, it was not a principal driving force in its creation. Since 1968, the concept of brain <span class="hlt">death</span> has been extensively analyzed, debated, and reworked. Still there remains much misunderstanding and confusion, especially in the general public. In this comprehensive review, I will trace the evolution of the definition of brain <span class="hlt">death</span> as <span class="hlt">death</span> from 1968 to the present, providing background, history and context. PMID:24930367</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23579043','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23579043"><span id="translatedtitle">Expressing <span class="hlt">death</span> risk as condensed life experience and <span class="hlt">death</span> intensity.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Ioannidis, John P A</p> <p>2013-08-01</p> <p>Some risk exposures, including many medical and surgical procedures, typically carry hazards of <span class="hlt">death</span> that are difficult to convey and appreciate in absolute terms. I propose presenting the <span class="hlt">death</span> risk as a condensed life experience (i.e., the equivalent amount of life T that would carry the same cumulative mortality hazard for a person of the same age and sex based on life tables). For example, if the risk of <span class="hlt">death</span> during an elective 1-hour procedure is 0.01%, and same-age and same-sex people have a 0.01% <span class="hlt">death</span> risk over 1 month, one can inform the patient that "this procedure carries the same <span class="hlt">death</span> risk as living 1 month of normal life." Comparative standards from other risky activities or from a person with the same disease at the same stage and same predictive profile could also be used. A complementary metric that may be useful to consider is the <span class="hlt">death</span> intensity. The <span class="hlt">death</span> intensity λ is the hazard function that shows the fold-risk estimate of dying compared with the reference person. The <span class="hlt">death</span> intensity can vary substantially for different phases of the event, operation, or procedure (e.g., intraoperative, early postoperative, late postoperative), and this variability may also be useful to convey. T will vary depending on the time window for which it is computed. I present examples for calculating T and λ using literature data on accidents, ascent to Mount Everest, and medical and surgical procedures. PMID:23579043</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED073378.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED073378.pdf"><span id="translatedtitle">Education for <span class="hlt">Death</span>, or <span class="hlt">Death</span> Becomes Less a Stranger.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Leviton, Dan</p> <p></p> <p>The purpose of this paper is to describe 1.) the <span class="hlt">Death</span> Education and Suicide Behavior course offered at the University of Maryland; 2.) the comments of the students both before and after the course as a means of determining any effect of the course; and 3.) some insights gained from teaching taboo topics such as human <span class="hlt">death</span> and sexuality. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3471793','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3471793"><span id="translatedtitle">Continued Increases in the Relative Risk of <span class="hlt">Death</span> From Smoking</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Preston, Samuel</p> <p>2012-01-01</p> <p>Objectives. We examined changes in the relative risk of <span class="hlt">death</span> among current and former smokers over recent decades in the United States. Methods. Data from the National Health Interview Survey (NHIS) and National Health and Nutrition Examination Survey (NHANES) were <span class="hlt">linked</span> to subsequent <span class="hlt">deaths</span>. We calculated age-standardized <span class="hlt">death</span> rates by gender and smoking status, and estimated multivariate discrete time logit regression models. Results. The risk of <span class="hlt">death</span> for a smoker compared with that for a never-smoker increased by 25.4% from 1987 to 2006 based on NHIS data. Analysis of NHANES data from 1971 to 2006 showed an even faster annual increase in the relative risk of <span class="hlt">death</span> for current smokers. Former smokers also showed an increasing relative risk of <span class="hlt">death</span>, although the increase was slower than that among current smokers and not always statistically significant. These trends were not related to increasing educational selectivity of smokers or increased smoking intensity or duration among current smokers. Smokers may have become more adversely selected on other health-related variables. Conclusions. A continuing increase in the relative risk of <span class="hlt">death</span> for current and former smokers suggests that the contribution of smoking to national mortality patterns is not decreasing as rapidly as would be implied by the decreasing prevalence of smoking among Americans. PMID:23050582</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5007344','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=5007344"><span id="translatedtitle"><span class="hlt">Sister</span> Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Ogino, Mai; Kinuta, Takatoshi; Hori, Masateru; Mori, Tatsuo</p> <p>2016-01-01</p> <p>A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a <span class="hlt">Sister</span> Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology. After surgery, the patient received chemotherapy with paclitaxel, carboplatin, and bevacizumab; however paclitaxel allergy was observed. As a result, chemotherapy continued with carboplatin and bevacizumab every three weeks for a total of 6 courses. Currently, she is still undergoing treatment with bevacizumab and CA125 levels have been progressively decreasing. SMJN is a rare umbilical metastasis which needs to be considered as a differential diagnosis in the presence of an umbilical tumor for prompt treatment initiation.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25456618','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25456618"><span id="translatedtitle">Challenging stereotypes? The older woman in the TV series Brothers & <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oró-Piqueras, Maricel</p> <p>2014-12-01</p> <p>The TV series, Brothers & <span class="hlt">Sisters</span>, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series. PMID:25456618</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/7006569','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/7006569"><span id="translatedtitle">Role of oxygen free radicals in the induction of <span class="hlt">sister</span> chromatid exchanges by cigarette smoke</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Lee, C.K.; Brown, B.G.; Rice, W.Y. Jr.; Doolittle, D.J. )</p> <p>1989-01-01</p> <p>Cigarette smoke has been reported to contain free radicals and free radical generators in both the gas and particulate phases. Studies in our laboratory have shown that both cigarette smoke condensate (CSC) and smoke bubbled through phosphate buffered saline solution (smoke-PBS) increased <span class="hlt">sister</span> chromatid exchanges (SCE) in Chinese hamster ovary cells in a dose-dependent manner. Since oxygen free radicals have been shown to cause SCEs and other chromosomal damage, we investigated the role of these radicals in the induction of SCEs by CSC and smoke-PBS. Addition of the antioxidant enzymes catalase and superoxide dismutase or the oxygen-radical scavenger ascorbic acid failed to reduce the SCE frequency in the presence of either CSC or smoke-PBS. Additional studies indicated that the quantity of hydrogen peroxide produced in CSC or smoke-PBS is too small to account for the observed SCE induction. It appears, therefore, that SCE induction by CSC or smoke-PBS does not involve the participation of oxygen free radicals.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25794146','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25794146"><span id="translatedtitle">Phylogenomic analyses of Echinodermata support the <span class="hlt">sister</span> groups of Asterozoa and Echinozoa.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Reich, Adrian; Dunn, Casey; Akasaka, Koji; Wessel, Gary</p> <p>2015-01-01</p> <p>Echinoderms (sea urchins, sea stars, brittle stars, sea lilies and sea cucumbers) are a group of diverse organisms, second in number within deuterostome species to only the chordates. Echinoderms serve as excellent model systems for developmental biology due to their diverse developmental mechanisms, tractable laboratory use, and close phylogenetic distance to chordates. In addition, echinoderms are very well represented in the fossil record, including some larval features, making echinoderms a valuable system for studying evolutionary development. The internal relationships of Echinodermata have not been consistently supported across phylogenetic analyses, however, and this has hindered the study of other aspects of their biology. In order to test echinoderm phylogenetic relationships, we sequenced 23 de novo transcriptomes from all five clades of echinoderms. Using multiple phylogenetic methods at a variety of sampling depths we have constructed a well-supported phylogenetic tree of Echinodermata, including support for the <span class="hlt">sister</span> groups of Asterozoa (sea stars and brittle stars) and Echinozoa (sea urchins and sea cucumbers). These results will help inform developmental and evolutionary studies specifically in echinoderms and deuterostomes in general. PMID:25794146</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/522865','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/522865"><span id="translatedtitle">DNA crosslinking, <span class="hlt">sister</span>-chromatid exchange and specific-locus mutations.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Carrano, A V; Thompson, L H; Stetka, D G; Minkler, J L; Mazrimas, J A; Fong, S</p> <p>1979-11-01</p> <p>Chinese hamster ovary cells were treated with the DNA-crosslinking chemicals, mitomycin C (MMC) and porfiromycin (POR), and their monofunctional derivative decarbamoyl mitomycin C (DCMMC). After exposure, the cells were studied for the induction of <span class="hlt">sister</span>-chromatid exchanges (SCEs) and mutations at the hypoxanthine phosphoribosyltransferase and adenine phosphoribosyltransferase loci. The frequency of SCEs varied significantly in successive sampling intervals, requiring the weighting of each interval by the percentage of second-division mitosis in that interval to obtain the mean SCE frequency for each dose. All 3 compounds were potent inducers of SCEs but weakly mutagenic. All 3 chemicals by concentration were approximately equally effective in inducing SCEs or mutations. When the induced SCEs and mutations were compared at equal levels of survival, DCMMC was slightly more effective than MMC or POR in inducing SCEs and somewhat less mutagenic. These results indicate that the DNA interstrand crosslink is not the major lesion responsible for the induction of SCE or mutation by these compounds. PMID:522865</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4368666','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4368666"><span id="translatedtitle">Phylogenomic Analyses of Echinodermata Support the <span class="hlt">Sister</span> Groups of Asterozoa and Echinozoa</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Reich, Adrian; Dunn, Casey; Akasaka, Koji; Wessel, Gary</p> <p>2015-01-01</p> <p>Echinoderms (sea urchins, sea stars, brittle stars, sea lilies and sea cucumbers) are a group of diverse organisms, second in number within deuterostome species to only the chordates. Echinoderms serve as excellent model systems for developmental biology due to their diverse developmental mechanisms, tractable laboratory use, and close phylogenetic distance to chordates. In addition, echinoderms are very well represented in the fossil record, including some larval features, making echinoderms a valuable system for studying evolutionary development. The internal relationships of Echinodermata have not been consistently supported across phylogenetic analyses, however, and this has hindered the study of other aspects of their biology. In order to test echinoderm phylogenetic relationships, we sequenced 23 de novo transcriptomes from all five clades of echinoderms. Using multiple phylogenetic methods at a variety of sampling depths we have constructed a well-supported phylogenetic tree of Echinodermata, including support for the <span class="hlt">sister</span> groups of Asterozoa (sea stars and brittle stars) and Echinozoa (sea urchins and sea cucumbers). These results will help inform developmental and evolutionary studies specifically in echinoderms and deuterostomes in general. PMID:25794146</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26643143','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26643143"><span id="translatedtitle">PICH promotes <span class="hlt">sister</span> chromatid disjunction and co-operates with topoisomerase II in mitosis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Nielsen, Christian F; Huttner, Diana; Bizard, Anna H; Hirano, Seiki; Li, Tian-Neng; Palmai-Pallag, Timea; Bjerregaard, Victoria A; Liu, Ying; Nigg, Erich A; Wang, Lily Hui-Ching; Hickson, Ian D</p> <p>2015-01-01</p> <p>PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numerous roles for PICH have been proposed from protein depletion experiments, but a consensus has failed to emerge. Here, we report that deletion of PICH in avian cells causes chromosome structural abnormalities, and hypersensitivity to an inhibitor of Topoisomerase II (Topo II), ICRF-193. ICRF-193-treated PICH(-/-) cells undergo <span class="hlt">sister</span> chromatid non-disjunction in anaphase, and frequently abort cytokinesis. PICH co-localizes with Topo IIα on UFBs and at the ribosomal DNA locus, and the timely resolution of both structures depends on the ATPase activity of PICH. Purified PICH protein strongly stimulates the catalytic activity of Topo II in vitro. Consistent with this, a human PICH(-/-) cell line exhibits chromosome instability and chromosome condensation and decatenation defects similar to those of ICRF-193-treated cells. We propose that PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID:26643143</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4686863','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4686863"><span id="translatedtitle">PICH promotes <span class="hlt">sister</span> chromatid disjunction and co-operates with topoisomerase II in mitosis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nielsen, Christian F.; Huttner, Diana; Bizard, Anna H.; Hirano, Seiki; Li, Tian-Neng; Palmai-Pallag, Timea; Bjerregaard, Victoria A.; Liu, Ying; Nigg, Erich A.; Wang, Lily Hui-Ching; Hickson, Ian D.</p> <p>2015-01-01</p> <p>PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numerous roles for PICH have been proposed from protein depletion experiments, but a consensus has failed to emerge. Here, we report that deletion of PICH in avian cells causes chromosome structural abnormalities, and hypersensitivity to an inhibitor of Topoisomerase II (Topo II), ICRF-193. ICRF-193-treated PICH−/− cells undergo <span class="hlt">sister</span> chromatid non-disjunction in anaphase, and frequently abort cytokinesis. PICH co-localizes with Topo IIα on UFBs and at the ribosomal DNA locus, and the timely resolution of both structures depends on the ATPase activity of PICH. Purified PICH protein strongly stimulates the catalytic activity of Topo II in vitro. Consistent with this, a human PICH−/− cell line exhibits chromosome instability and chromosome condensation and decatenation defects similar to those of ICRF-193-treated cells. We propose that PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. PMID:26643143</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4976385','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4976385"><span id="translatedtitle">Ringiculid bubble snails recovered as the <span class="hlt">sister</span> group to sea slugs (Nudipleura)</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kano, Yasunori; Brenzinger, Bastian; Nützel, Alexander; Wilson, Nerida G.; Schrödl, Michael</p> <p>2016-01-01</p> <p>Euthyneuran gastropods represent one of the most diverse lineages in Mollusca (with over 30,000 species), play significant ecological roles in aquatic and terrestrial environments and affect many aspects of human life. However, our understanding of their evolutionary relationships remains incomplete due to missing data for key phylogenetic lineages. The present study integrates such a neglected, ancient snail family Ringiculidae into a molecular systematics of Euthyneura for the first time, and is supplemented by the first microanatomical data. Surprisingly, both molecular and morphological features present compelling evidence for the common ancestry of ringiculid snails with the highly dissimilar Nudipleura—the most species-rich and well-known taxon of sea slugs (nudibranchs and pleurobranchoids). A new taxon name Ringipleura is proposed here for these long-lost <span class="hlt">sisters</span>, as one of three major euthyneuran clades with late Palaeozoic origins, along with Acteonacea (Acteonoidea + Rissoelloidea) and Tectipleura (Euopisthobranchia + Panpulmonata). The early Euthyneura are suggested to be at least temporary burrowers with a characteristic ‘bubble’ shell, hypertrophied foot and headshield as exemplified by many extant subtaxa with an infaunal mode of life, while the expansion of the mantle might have triggered the explosive Mesozoic radiation of the clade into diverse ecological niches. PMID:27498754</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5997976','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5997976"><span id="translatedtitle">Proliferative kinetics of human lymphocytes in culture measured by autoradiography and <span class="hlt">sister</span> chromatid differential staining</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Morimoto, K.; Sato, M.; Koizumi, A.</p> <p>1983-01-01</p> <p>A simple combination of autoradiography, to determine when a cell synthesized DNA, and <span class="hlt">sister</span> chromatid differential staining, to determine how many times a cell has divided, was used to follow up the proliferating fate of human lymphocytes in culture. Cells were incubated continuously with 5-bromodeoxyuridine (BrdU) and pulse-labelled with 0.1 ..mu..Ci/ml (/sup 3/H)thymidine at various times after stimulation with phytohemagglutinin (PHA). The cells were then harvested at 4 h intervals up to 72 h, and the percentage of labelled mitoses was determined separately in first, second, or third division cells. The data showed that the cycling cells, whether they began cycling at earlier or later times after stimulation, had about the same generation times of 12-14 h. This confirms that the heterogeneity of cell generations seen in short-term lymphocyte cultures is in large part due to the difference in the times when cells began cell cycling in response to PHA. 34 references, 2 figures, 1 table.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5738888','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5738888"><span id="translatedtitle">Enhanced response to the induction of <span class="hlt">sister</span> chromatid exchange by gamma radiation in neurofibromatosis</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Hafez, M.; Abd el-Nabi, S.M.; el-Wehedi, G.; Al-Tonbary, Y.</p> <p>1986-05-15</p> <p>The study included 8 unrelated patients with neurofibromatosis, and 10 unrelated normal and healthy persons as controls. Whole blood samples were divided into plastic T flasks and exposed at room temperature to gamma rays. The radiation dose was 36 rad/minute, and the doses delivered were 0, 75, 150 and 300 rad. The lymphocytes were cultured in (RPMI) 1640 tissue culture medium and autologous serum (20%). Phytohemagglutinin and bromodeoxyuridine (Brdu) (10 microM) were added at initiation of culture and harvesting was done 64 to 68 hours after culture initiation. Slides were coded, differential staining was done, and <span class="hlt">sister</span> chromatid exchanges (SCEs) and aberrations (gaps, breaks, dicentrics, fragments and minutes) were counted. In the controls no significant increase in frequency of SCE has been found (P greater than 0.5). In the patients, the frequencies significantly increased with the increase of dose of irradiation (P less than 0.001). Furthermore, after irradiation, the incidence of gaps, breaks, and dicentrics were significantly increased in patients compared with controls. Moreover, the incidence increased with the increase in the dose of radiation. The results are discussed with a conclusion that the results add to the indication of a genetic predisposition to develop cancer in neurofibromatosis patients.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1151984','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1151984"><span id="translatedtitle">Unique Mitochondrial Genome Structure in Diplonemids, the <span class="hlt">Sister</span> Group of Kinetoplastids</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Marande, William; Lukeš, Julius; Burger, Gertraud</p> <p>2005-01-01</p> <p>Kinetoplastid flagellates are characterized by uniquely massed mitochondrial DNAs (mtDNAs), the kinetoplasts. Kinetoplastids of the trypanosomatid group possess two types of mtDNA molecules: maxicircles bearing protein and mitoribosomal genes and minicircles specifying guide RNAs, which mediate uridine insertion/deletion RNA editing. These circles are interlocked with one another to form dense networks. Whether these peculiar mtDNA features are restricted to kinetoplastids or prevail throughout Euglenozoa (euglenids, diplonemids, and kinetoplastids) is unknown. Here, we describe the mitochondrial genome and the mitochondrial ultrastructure of Diplonema papillatum, a member of the diplonemid flagellates, the <span class="hlt">sister</span> group of kinetoplastids. Fluorescence and electron microscopy show a single mitochondrion per cell with an ultrastructure atypical for Euglenozoa. In addition, DNA is evenly distributed throughout the organelle rather than compacted. Molecular and electron microscopy studies distinguish numerous 6- and 7-kbp-sized mitochondrial chromosomes of monomeric circular topology and relaxed conformation in vivo. Remarkably, the cox1 gene (and probably other mitochondrial genes) is fragmented, with separate gene pieces encoded on different chromosomes. Generation of the contiguous cox1 mRNA requires trans-splicing, the precise mechanism of which remains to be determined. Taken together, the mitochondrial gene/genome structure of Diplonema is not only different from that of kinetoplastids but unique among eukaryotes as a whole. PMID:15947205</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25077515','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25077515"><span id="translatedtitle">Coalescent versus concatenation methods and the placement of Amborella as <span class="hlt">sister</span> to water lilies.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Xi, Zhenxiang; Liu, Liang; Rest, Joshua S; Davis, Charles C</p> <p>2014-11-01</p> <p>The molecular era has fundamentally reshaped our knowledge of the evolution and diversification of angiosperms. One outstanding question is the phylogenetic placement of Amborella trichopoda Baill., commonly thought to represent the first lineage of extant angiosperms. Here, we leverage publicly available data and provide a broad coalescent-based species tree estimation of 45 seed plants. By incorporating 310 nuclear genes, our coalescent analyses strongly support a clade containing Amborella plus water lilies (i.e., Nymphaeales) that is <span class="hlt">sister</span> to all other angiosperms across different nucleotide rate partitions. Our results also show that commonly applied concatenation methods produce strongly supported, but incongruent placements of Amborella: slow-evolving nucleotide sites corroborate results from coalescent analyses, whereas fast-evolving sites place Amborella alone as the first lineage of extant angiosperms. We further explored the performance of coalescent versus concatenation methods using nucleotide sequences simulated on (i) the two alternate placements of Amborella with branch lengths and substitution model parameters estimated from each of the 310 nuclear genes and (ii) three hypothetical species trees that are topologically identical except with respect to the degree of deep coalescence and branch lengths. Our results collectively suggest that the Amborella alone placement inferred using concatenation methods is likely misled by fast-evolving sites. This appears to be exacerbated by the combination of long branches in stem group angiosperms, Amborella, and Nymphaeales with the short internal branch separating Amborella and Nymphaeales. In contrast, coalescent methods appear to be more robust to elevated substitution rates. PMID:25077515</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24815896','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24815896"><span id="translatedtitle">Fear and loathing in Mississippi: the attack on cAMP <span class="hlt">sister</span> spirit.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Greene, Kate</p> <p>2003-01-01</p> <p>SUMMARY In 1993, the small rural community of Ovett, Miss., and a group of self-described radical lesbian feminists clashed over the establishment by the women of a feminist educational retreat known as Camp <span class="hlt">Sister</span> Spirit. This dispute took the form of physical and psychological harassment of the women, wide-open public debate in the community, in the press, and on television, federal mediation efforts, and two lawsuits. This article analyzes this dispute using Mary Daly's seven patterns of the sado-ritual syndrome (Daly, 1978). The analysis examines the ideological and moral standpoints of the participants, the issues of "blaming the victim" and scapegoating, the development of the conflict from a dispute between neighbors to the involvement of international media, national activists and the Clinton Administration, the transformation of the conflict from a political to legal dispute, the representations of the groups within the community and the media, the effect of public opinion on the dispute, and the politics of the media in the dispute. PMID:24815896</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012HMR....66..363M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012HMR....66..363M"><span id="translatedtitle">Chromosomal differentiation and speciation in <span class="hlt">sister</span>-species of Grammatidae (Perciformes) from the Western Atlantic</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Molina, Wagner Franco; da Costa, Gideão Wagner Werneck Felix; de Bello Cioffi, Marcelo; Bertollo, Luiz Antonio Carlos</p> <p>2012-09-01</p> <p>In the tropical Atlantic, the ichthyofauna between the coast of Brazil and the Caribbean regions, divided by the Amazon barrier, is very similar presenting several geminate species, including Gramma brasiliensis, endemic in Brazil, and its Caribbean counterpart Gramma loreto. Morphological and molecular studies have helped establish evolutionary patterns that <span class="hlt">sister</span>-species of these two marine habitats are subjected to. However, their chromosomal characteristics are only beginning to be better characterized. Accordingly, a comparative cytogenetic analysis was carried out in G. brasiliensis and G. loreto, seeking evidence of cytotaxonomic markers implicated in the karyotypic diversification of these species and likely associated with speciation events. Heterochromatic regions and their affinity to fluorochromes GC- or AT-specific were identified, as well as the distribution of ribosomal DNA sites in chromosomes, either by silver nitrate impregnation (Ag-NORs) or dual-color FISH mapping with 18S and 5S rDNA probes. While displaying the same diploid number, 2 n = 48 chromosomes, considered basal for Perciformes, the two species differed in karyotype structure, showing karyotypic formulas and species-specific heterochromatin pattern. The cytological characters found support the differentiating status of these species, possibly achieved under the conditions of allopatry due to the Amazon/Orinoco barrier, showing chromosomal peculiarities in Grammatidae species when compared to other groups of Perciformes.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7687025','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7687025"><span id="translatedtitle">The correlation between the frequency of <span class="hlt">sister</span>-chromatid exchange and human reproductive hormones.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Joseph-Lerner, N; Fejgin, M; Ben-Nun, I; Legum, C; Amiel, A</p> <p>1993-08-01</p> <p>Different frequencies of <span class="hlt">sister</span>-chromatid exchanges (SCEs) during various stages of the menstrual cycle have previously been observed. We tested the hypothesis that sex hormones, particularly steroids, influence the frequency of SCEs in women undergoing ovulation induction for in vitro fertilization treatment. These women undergo extreme hormonal changes and therefore serve as a good model for testing the rate of genetic damage due to these changes. As controls, we tested fertile women with regular menstrual cycles who received no hormonal treatment. Peripheral lymphocytes were obtained during different stages of the normal and treated cycles. We examined SCE frequency as related to the different hormones of the reproductive cycle at each of the stages. In general, an increased SCE frequency was observed around ovulation time in the controls, and around the time of human chorionic gonadotropin administration in the group undergoing ovulation induction. However, in the latter group, SCE frequency was significantly higher. SCE frequency was positively correlated with the level of testosterone and FSH in the ovulation induction group, and positively correlated with the estradiol level in both groups. PMID:7687025</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635493','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635493"><span id="translatedtitle">Effects of <span class="hlt">sister</span> chromatid cohesion proteins on cut gene expression during wing development in Drosophila</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Dorsett, Dale; Eissenberg, Joel C.; Misulovin, Ziva; Martens, Andrew; Redding, Bethany; McKim, Kim</p> <p>2006-01-01</p> <p>Summary The cohesin protein complex is a conserved structural component of chromosomes. Cohesin binds numerous sites along interphase chromosomes and is essential for <span class="hlt">sister</span> chromatid cohesion and DNA repair. Here, we test the idea that cohesin also regulates gene expression. This idea arose from the finding that the Drosophila Nipped-B protein, a functional homolog of the yeast Scc2 factor that loads cohesin onto chromosomes, facilitates the transcriptional activation of certain genes by enhancers located many kilobases away from their promoters. We find that cohesin binds between a remote wing margin enhancer and the promoter at the cut locus in cultured cells, and that reducing the dosage of the Smc1 cohesin subunit increases cut expression in the developing wing margin. We also find that cut expression is increased by a unique pds5 gene mutation that reduces the binding of cohesin to chromosomes. On the basis of these results, we posit that cohesin inhibits long-range activation of the Drosophila cut gene, and that Nipped-B facilitates activation by regulating cohesin-chromosome binding. Such effects of cohesin on gene expression could be responsible for many of the developmental deficits that occur in Cornelia de Lange syndrome, which is caused by mutations in the human homolog of Nipped-B. PMID:16207752</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20232130','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20232130"><span id="translatedtitle">Birth order and ratio of brothers to <span class="hlt">sisters</span> in Spanish transsexuals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio</p> <p>2011-06-01</p> <p>Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than <span class="hlt">sisters</span>. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism. PMID:20232130</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2091924','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2091924"><span id="translatedtitle">Chromosome aberration and <span class="hlt">sister</span> chromatid exchange test results with 42 chemicals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Anderson, B E; Zeiger, E; Shelby, M D; Resnick, M A; Gulati, D K; Ivett, J L; Loveday, K S</p> <p>1990-01-01</p> <p>Forty-two chemicals were tested for their ability to induce cytogenetic change in Chinese hamster ovary cells using assays for chromosome aberrations (ABS) and <span class="hlt">sister</span> chromatid exchanges (SCE). These chemicals were included in the National Toxicology Program's evaluation of the ability of four in vitro short-term genetic toxicity assays to distinguish between rodent carcinogens and noncarcinogens. The conclusions of this comparison are presented in Zeiger et al. [Zeiger E, Haseman JK, Shelby MD, Margolin BH, Tennant RW (1990): [Environ Molec Mutagen 16(Suppl 18): 1-14]. The in vitro cytogenetic testing was conducted at four laboratories, each using a standard protocol to evaluate coded chemicals with and without exogenous metabolic activation. Most chemicals were tested in a single laboratory; however, two chemicals, tribromomethane and p-chloroaniline, were tested at two laboratories as part of an interlaboratory comparison. Four chemicals (C.I. basic red 9 HCl, 2-mercaptobenzothiazole, oxytetracycline HCl, and rotenone) were tested for SCE in one laboratory and in a different laboratory for ABS. Tetrakis(hydroxymethyl)phosphonium sulfate was tested at one laboratory and the chloride form was tested at a different laboratory. Twenty-five of the 42 chemicals tested induced SCE. Sixteen of these also induced ABS; all chemicals that induced ABS also induced SCE. There was approximately 79% reproducibility of results in repeat tests, thus, we conclude that this protocol is effective and reproducible in detecting ABS and SCE. PMID:2091924</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/1617475','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/1617475"><span id="translatedtitle">Effects of older brother-younger <span class="hlt">sister</span> incest: a study of the dynamics of 17 cases.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Laviola, M</p> <p>1992-01-01</p> <p>The purpose of this study was to explore the effects of older brother-younger <span class="hlt">sister</span> incest from the perspective of the women who experienced it in childhood or adolescent years. Dynamics in the families-of-origin were also explored, as these related or contributed to the effects from the incest. Seventeen women were interviewed, using an in-depth, semi-structured interview. Four self-report objective instruments were also administered that measure dynamics in the family-of-origin and symptomatology that is often associated with the effects of trauma. Interview and objective data were analyzed by systematically organizing the women's perceptions and conceptualizations into common themes. All of the women's families of origin were described as dysfunctional. Common effects reported included mistrust of men and women, chronic low or negative self-esteem, sexual response difficulties, and intrusive thoughts of the incest. Women regarded individual therapy, talking with supportive family and friends, and validating themselves as victims at the time of the incest as ways in which they have helped themselves to deal with the effects of the incest. These results have important implications for therapy, including serious consideration of the impact and contribution of this kind of incest on reported symptomatology, and on emerging issues and conflicts in the therapeutic process. PMID:1617475</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27026021','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27026021"><span id="translatedtitle">Divergence in male cricket song and female preference functions in three allopatric <span class="hlt">sister</span> species.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hennig, Ralf Matthias; Blankers, Thomas; Gray, David A</p> <p>2016-05-01</p> <p>Multivariate female preference functions for male sexual signals have rarely been investigated, especially in a comparative context among <span class="hlt">sister</span> species. Here we examined male signal and female preference co-variation in three closely related, but allopatric species of Gryllus crickets and quantified male song traits as well as female preferences. We show that males differ conspicuously in either one of two relatively static song traits, carrier frequency or pulse rate; female preference functions for these traits also differed, and would in combination enhance species discrimination. In contrast, the relatively dynamic song traits, chirp rate and chirp duty cycle, show minimal divergence among species and relatively greater conservation of female preference functions. Notably, among species we demonstrate similar mechanistic rules for the integration of pulse and chirp time scales, despite divergence in pulse rate preferences. As these are allopatric taxa, selection for species recognition per se is unlikely. More likely sexual selection combined with conserved properties of preference filters enabled divergent coevolution of male song and female preferences. PMID:27026021</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24797474','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24797474"><span id="translatedtitle">Meiotic cohesin STAG3 is required for chromosome axis formation and <span class="hlt">sister</span> chromatid cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Winters, Tristan; McNicoll, Francois; Jessberger, Rolf</p> <p>2014-06-01</p> <p>The cohesin complex is essential for mitosis and meiosis. The specific meiotic roles of individual cohesin proteins are incompletely understood. We report in vivo functions of the only meiosis-specific STAG component of cohesin, STAG3. Newly generated STAG3-deficient mice of both sexes are sterile with meiotic arrest. In these mice, meiotic chromosome architecture is severely disrupted as no bona fide axial elements (AE) form and homologous chromosomes do not synapse. Axial element protein SYCP3 forms dot-like structures, many partially overlapping with centromeres. Asynapsis marker HORMAD1 is diffusely distributed throughout the chromatin, and SYCP1, which normally marks synapsed axes, is largely absent. Centromeric and telomeric <span class="hlt">sister</span> chromatid cohesion are impaired. Centromere and telomere clustering occurs in the absence of STAG3, and telomere structure is not severely affected. Other cohesin proteins are present, localize throughout the STAG3-devoid chromatin, and form complexes with cohesin SMC1β. No other deficiency in a single meiosis-specific cohesin causes a phenotype as drastic as STAG3 deficiency. STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin. PMID:24797474</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21597907','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21597907"><span id="translatedtitle">Double effect, all over again: the case of <span class="hlt">Sister</span> Margaret McBride.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Prusak, Bernard G</p> <p>2011-08-01</p> <p>As media reports have made widely known, in November 2009, the ethics committee of St. Joseph's Hospital in Phoenix, Arizona, permitted the abortion of an eleven-week-old fetus in order to save the life of its mother. This woman was suffering from acute pulmonary hypertension, which her doctors judged would prove fatal for both her and her previable child. The ethics committee believed abortion to be permitted in this case under the so-called principle of double effect, but Thomas J. Olmsted, the bishop of Phoenix, disagreed with the committee and pronounced its chair, <span class="hlt">Sister</span> Margaret McBride, excommunicated latae sententiae, "by the very commission of the act." In this article, I take the much discussed Phoenix case as an occasion to subject the principle of double effect to another round of philosophical scrutiny. In particular, I examine the third condition of the principle in its textbook formulation, namely, that the evil effect in question may not be the means to the good effect. My argument, in brief, is that the textbook formulation of the principle does not withstand philosophical scrutiny. Nevertheless, in the end, I do not claim that we should then "do away" with the principle altogether. Instead, we do well to understand it within the context of casuistry, the tradition of moral reasoning from which it issued. PMID:21597907</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4344150','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4344150"><span id="translatedtitle">Comparison of <span class="hlt">sister</span> species identifies factors underpinning plastid compatibility in green sea slugs</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>de Vries, Jan; Woehle, Christian; Christa, Gregor; Wägele, Heike; Tielens, Aloysius G. M.; Jahns, Peter; Gould, Sven B.</p> <p>2015-01-01</p> <p>The only animal cells known that can maintain functional plastids (kleptoplasts) in their cytosol occur in the digestive gland epithelia of sacoglossan slugs. Only a few species of the many hundred known can profit from kleptoplasty during starvation long-term, but why is not understood. The two <span class="hlt">sister</span> taxa Elysia cornigera and Elysia timida sequester plastids from the same algal species, but with a very different outcome: while E. cornigera usually dies within the first two weeks when deprived of food, E. timida can survive for many months to come. Here we compare the responses of the two slugs to starvation, blocked photosynthesis and light stress. The two species respond differently, but in both starvation is the main denominator that alters global gene expression profiles. The kleptoplasts' ability to fix CO2 decreases at a similar rate in both slugs during starvation, but only E. cornigera individuals die in the presence of functional kleptoplasts, concomitant with the accumulation of reactive oxygen species (ROS) in the digestive tract. We show that profiting from the acquisition of robust plastids, and key to E. timida's longer survival, is determined by an increased starvation tolerance that keeps ROS levels at bay. PMID:25652835</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25999054','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25999054"><span id="translatedtitle">Phylogenomic analyses reveal subclass Scuticociliatia as the <span class="hlt">sister</span> group of subclass Hymenostomatia within class Oligohymenophorea.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Feng, Jin-Mei; Jiang, Chuan-Qi; Warren, Alan; Tian, Miao; Cheng, Jun; Liu, Guang-Long; Xiong, Jie; Miao, Wei</p> <p>2015-09-01</p> <p>Scuticociliates and hymenostomes are two groups of the ciliate class Oligohymenophorea, a diverse clade that includes two model genera, Tetrahymena and Paramecium, which have been intensively studied due to their ease of culture and their amenability to a wide range of biochemical and genetic investigations. However, phylogenetic relationships among the subclasses of the Oligohymenophorea, and especially between the Scuticociliatia and Hymenostomatia, are not clearly resolved. Here, we investigate the phylogenetic relationship between the subclasses Scuticociliatia and Hymenostomatia based on omics data. The transcriptomes of five species, comprising four oligohymenophoreans and one colpodean, were sequenced. A supermatrix was constructed for phylogenomic analyses based on 113 genes encoding 43,528 amino acid residues from 26 taxa, including ten representatives of the class Oligohymenophorea. Our phylogenomic analyses revealed that the monophyletic Scuticociliatia is <span class="hlt">sister</span> to the monophyletic Hymenostomatia, which together form the terminal branch within the monophyletic class Oligohymenophorea. Competing hypotheses for this relationship were rejected by topological tests. Our results provide corroborative evidence for the close relationship between the subclasses Scuticociliatia and Hymenostomatia, justifying the possible use of the model hymenostome T. thermophila as an effective experimental system to study the molecular and cellular biology of the scuticociliates. PMID:25999054</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6922005','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6922005"><span id="translatedtitle">Effects of cigarette smoking and solvent exposure on <span class="hlt">sister</span> chromatid exchange frequency in painters</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kelsey, K.T.; Wiencke, J.K.; Little, F.F.; Baker, E.L. Jr.; Little, J.B.</p> <p>1988-01-01</p> <p>A cross-sectional study of <span class="hlt">sister</span> chromatid exchange frequency (SCE) in peripheral blood lymphocytes from 117 members of the International Brotherhood of Painters and Allied Tradesman was conducted in union locals in two major US cities. Chronic solvent exposure intensity and duration were estimated from interviewer-administered-questionnaire data. SCE for all of the workers in the study were scored by one reader. A second reader determined the SCE frequency from a random sample of 30 workers. Age, coffee and alcohol intake and chronic solvent exposure (both intensity and duration, estimated over the working lifetime and over the year prior to study for each worker) did not significantly elevate SCE. The effect of smoking on SCE frequency, assessed by analysis of variance controlling for other possible confounding factors, showed that smoking increased SCE frequency. The SCE frequency in the smoking, solvent-exposed (estimated as lifetime exposure) painters were 6.75 SCE/cell; in the non-smoking, solvent-exposed workers the SCE frequency was 5.73 SCE/cell. These observations are consistent with other work suggesting that chronic solvent exposure in the paint trade is not associated with an elevation in SCE in peripheral blood lymphocytes. However, further work is necessary to address adequately the question of the genotoxicity of acute solvent exposure in these workers.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6415339','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6415339"><span id="translatedtitle">Induction of <span class="hlt">sister</span> chromatid exchanges by coal dust and tobacco snuff extracts in human peripheral lymphocytes</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Tucker, J.D.; Ong, T.</p> <p>1985-01-01</p> <p>The organic solvent extracts of sub-bituminous coal dust and tobacco snuff, both together and separately, were tested for the induction of <span class="hlt">sister</span> chromatid exchanges (SCEs) in human peripheral lymphocytes. The results indicate that these extracts induced SCEs, and that when tested together synergistically induced SCEs in two of three donors. Studies with the organic solvent extracts of all five ranks of coal indicate that the extracts of bituminous, lignite, and peat, but not anthracite, induced SCEs. Similar experiments conducted with water extracts, induced SCEs, and that anthracite was equivocal. To determine whether individuals differed in their SCE responses to coal dust extracts, lymphocytes from five donors were tested with organic solvent extracts of bituminous and sub-bituminous coal. An analysis of variance indicates that the SCE response was significantly influenced by the donor and each of the two coal extracts. The findings presented here suggest that coal dust, with or without tobacco snuff, may play a role in the elevated incidence of gastric cancer in coal miners. Because water extracts of some ranks of coal induced SCEs, there exists the possibility of adverse environmental effects due to coal leachates.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25990877','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25990877"><span id="translatedtitle">p53 gene discriminates two ecologically divergent <span class="hlt">sister</span> species of pine voles.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Quina, A S; Bastos-Silveira, C; Miñarro, M; Ventura, J; Jiménez, R; Paulo, O S; da Luz Mathias, M</p> <p>2015-11-01</p> <p>Genes with relevant roles in the differentiation of closely-related species are likely to have diverged simultaneously with the species and more accurately reproduce the species tree. The Lusitanian (Microtus lusitanicus) and Mediterranean (M. duodecimcostatus) pine voles are two recently separated <span class="hlt">sister</span> species with fossorial lifestyles whose different ecological, physiological and morphological phenotypes reflect the better adaptation of M. duodecimcostatus to the underground habitat. Here we asked whether the differentiation of M. lusitanicus and M. duodecimcostatus involved genetic variations within the tumour suppressor p53 gene, given its role in stress-associated responses. We performed a population-genetic analysis through sequencing of exons and introns of p53 in individuals from sympatric and allopatric populations of both the species in the Iberian Peninsula in which a unidirectional introgression of mitochondrial DNA was previously observed. We were able to discriminate the two species to a large extent. We show that M. duodecimcostatus is composed of one genetically unstructured group of populations sharing a P53 protein that carries a mutation in the DNA-binding region not observed in M. lusitanicus, raising the possibility that this mutation may have been central in the evolutionary history of M. duodecimcostatus. Our results provide suggestive evidence for the involvement of a master transcription factor in the separation of M. lusitanicus and M. duodecimcostatus during Microtus radiation in the Quaternary presumably via a differential adaptive role of the novel p53 in M. duodecimcostatus. PMID:25990877</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/17431321','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/17431321"><span id="translatedtitle">Elevated <span class="hlt">sister</span> chromatid exchange frequencies in New Zealand Vietnam War veterans.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rowland, R E; Edwards, L A; Podd, J V</p> <p>2007-01-01</p> <p>From July 1965 until November 1971, New Zealand Defence Force Personnel fought in the Vietnam War. During this time more than 76,500,000 litres of phenoxylic herbicides were sprayed over parts of Southern Vietnam and Laos, the most common being known as 'Agent Orange'. The current study aimed to ascertain whether or not New Zealand Vietnam War veterans show evidence of genetic disturbance arising as a consequence of their now confirmed exposure to these defoliants. A sample group of 24 New Zealand Vietnam War veterans and 23 control volunteers were compared using an SCE (<span class="hlt">sister</span> chromatid exchange) analysis. The results from the SCE study show a highly significant difference (P < 0.001) between the mean of the experimental group (11.05) and the mean of a matched control group (8.18). The experimental group also has an exceptionally high proportion of HFCs (cells with high SCE frequencies) above the 95th percentile compared to the controls (11.0 and 0.07%, respectively). We conclude that the New Zealand Vietnam War veterans studied here were exposed to a clastogenic substance(s) which continues to exert an observable genetic effect today, and suggest that this is attributable to their service in Vietnam. PMID:17431321</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3784504','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3784504"><span id="translatedtitle">Histone Chaperone NAP1 Mediates <span class="hlt">Sister</span> Chromatid Resolution by Counteracting Protein Phosphatase 2A</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kan, Tsung-Wai; Chalkley, Gillian E.; Sap, Karen; Bezstarosti, Karel; Demmers, Jeroen A.; Ozgur, Zeliha; van Ijcken, Wilfred F. J.; Verrijzer, C. Peter</p> <p>2013-01-01</p> <p>Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and <span class="hlt">sister</span> chromatid resolution during mitosis. Genome-wide surveys revealed that NAP1 and cohesin co-localize at multiple genomic loci. Proteomic and biochemical analysis established that NAP1 associates with the full cohesin complex, but it also forms a separate complex with the cohesin subunit stromalin (SA). NAP1 binding to cohesin is cell-cycle regulated and increases during G2/M phase. This causes the dissociation of protein phosphatase 2A (PP2A) from cohesin, increased phosphorylation of SA and cohesin removal in early mitosis. PP2A depletion led to a loss of centromeric cohesion. The distinct mitotic phenotypes caused by the loss of either PP2A or NAP1, were both rescued by their concomitant depletion. We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis. PMID:24086141</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19591384','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19591384"><span id="translatedtitle">Palaeopathological diagnosis after 2500 years. The case of Imakhetkherresnet, <span class="hlt">sister</span> of priest Iufaa.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Strouhal, E; Nĕmecková, A</p> <p>2009-01-01</p> <p>The aim of palaeopathological studies has been traditionally the determination of a diagnosis of any found pathological change. If based merely on skeletal evidence, most of them proved to be only tentative. Our case of the mature female Imakhetkherresnet, <span class="hlt">sister</span> of the lector-priest Iufaa, having preserved scraps of soft tissue, enabled a precise diagnosis. Her skeletized mummy was discovered in Iufaa's unmolested tomb dating late 26th Dynasty at Abusir (Egypt) by the Czech Institute of Egyptology in 2001. A large smooth-walled cavity moulded by pressure of a relatively hard, globular and lobulated tissue mass was found inside the sacrum, growing in hour-glass shape outside it. By macroscopic and radiographic examination its diagnosis was suggested, while by histological analysis with histochemical tests and comparison with a recent case, the origin of the hollow could be "clinically" determined. It was caused by a benign tumour, originating in the nerve sheath, called neurilemmoma (schwannoma, neurinoma). This kind of tumour, occurring in the sacrum relatively rarely, was never before described in the palaeopathological literature. PMID:19591384</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26391726','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26391726"><span id="translatedtitle">Competitive avoidance not edaphic specialization drives vertical niche partitioning among <span class="hlt">sister</span> species of ectomycorrhizal fungi.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Mujic, Alija B; Durall, Daniel M; Spatafora, Joseph W; Kennedy, Peter G</p> <p>2016-02-01</p> <p>Soil depth partitioning is thought to promote the diversity of ectomycorrhizal (EM) fungal communities, but little is known about whether it is controlled by abiotic or biotic factors. In three bioassay experiments, we tested the role of vertical soil heterogeneity in determining the distributions and competitive outcomes of the EM <span class="hlt">sister</span> species Rhizopogon vinicolor and Rhizopogon vesiculosus. We planted Pseudotsuga menziesii seedlings into soils that were either a homogenized mix of upper and lower depths or vertically stratified combinations mimicking natural field conditions. We found that both species colonized the upper or lower soil depths in the absence of competition, suggesting that their distributions were not limited by abiotic edaphic factors. In competition within homogeneous soils, R. vesiculosus completely excluded colonization by R. vinicolor, but R. vinicolor was able to persist when soils were stratified. The amount of colonization by R. vinicolor in the stratified soils was also significantly correlated with the number of multilocus genotypes present. Taken together, our findings suggest that the differential vertical distributions of R. vinicolor and R. vesiculosus in natural settings are probably attributable to competition rather than edaphic specialization, but that soil heterogeneity may play a key role in promoting EM fungal diversity. PMID:26391726</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25054146','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25054146"><span id="translatedtitle">Homozygous inactivating mutation in NANOS3 in two <span class="hlt">sisters</span> with primary ovarian insufficiency.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Santos, Mariza G; Machado, Aline Z; Martins, Conceição N; Domenice, Sorahia; Costa, Elaine M F; Nishi, Mirian Y; Ferraz-de-Souza, Bruno; Jorge, Soraia A C; Pereira, Carlos A; Soardi, Fernanda C; de Mello, Maricilda P; Maciel-Guerra, Andrea T; Guerra-Junior, Gil; Mendonca, Berenice B</p> <p>2014-01-01</p> <p>Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained. The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. We performed mutational analysis of NANOS3 in a cohort of 85 Brazilian women with familial or isolated POI, presenting with primary or secondary amenorrhea, and in ethnically-matched control women. A homozygous p.Glu120Lys mutation in NANOS3 was identified in two <span class="hlt">sisters</span> with primary amenorrhea. The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. In vitro analyses of apoptosis through flow cytometry and confocal microscopy show that NANOS3 capacity to prevent apoptosis was impaired by this mutation. The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. PMID:25054146</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4098983','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4098983"><span id="translatedtitle">Homozygous Inactivating Mutation in NANOS3 in Two <span class="hlt">Sisters</span> with Primary Ovarian Insufficiency</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Santos, Mariza G.; Machado, Aline Z.; Martins, Conceição N.; Domenice, Sorahia; Costa, Elaine M. F.; Nishi, Mirian Y.; Ferraz-de-Souza, Bruno; Jorge, Soraia A. C.; Pereira, Carlos A.; Soardi, Fernanda C.; de Mello, Maricilda P.; Maciel-Guerra, Andrea T.; Guerra-Junior, Gil; Mendonca, Berenice B.</p> <p>2014-01-01</p> <p>Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained. The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. We performed mutational analysis of NANOS3 in a cohort of 85 Brazilian women with familial or isolated POI, presenting with primary or secondary amenorrhea, and in ethnically-matched control women. A homozygous p.Glu120Lys mutation in NANOS3 was identified in two <span class="hlt">sisters</span> with primary amenorrhea. The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. In vitro analyses of apoptosis through flow cytometry and confocal microscopy show that NANOS3 capacity to prevent apoptosis was impaired by this mutation. The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. PMID:25054146</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24336965','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24336965"><span id="translatedtitle">Geographic determinants of gene flow in two <span class="hlt">sister</span> species of tropical Andean frogs.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Guarnizo, Carlos E; Cannatella, David C</p> <p>2014-01-01</p> <p>Complex interactions between topographic heterogeneity, climatic and environmental gradients, and thermal niche conservatism are commonly assumed to indicate the degree of biotic diversification in montane regions. Our aim was to investigate factors that disrupt gene flow between populations and to determine if there is evidence of downslope asymmetric migration in highland frogs with wide elevational ranges and thermal niches. We determined the role of putative impediments to gene flow (as measured by least-cost path (LCP) distances, topographic complexity, and elevational range) in promoting genetic divergence between populations of 2 tropical Andean frog <span class="hlt">sister</span> species (Dendropsophus luddeckei, N = 114; Dendropsophus labialis, N = 74) using causal modeling and multiple matrix regression. Although the effect of geographic features was species specific, elevational range and LCP distances had the strongest effect on gene flow, with mean effect sizes (Mantel r and regression coefficients β), between 5 and 10 times greater than topographic complexity. Even though causal modeling and multiple matrix regression produced congruent results, the latter provided more information on the contribution of each geographic variable. We found moderate support for downslope migration. We conclude that the climatic heterogeneity of the landscape, the elevational distance between populations, and the inability to colonize suboptimal habitats due to thermal niche conservatism influence the magnitude of gene flow. Asymmetric migration, however, seems to be influenced by life history traits. PMID:24336965</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27498754','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27498754"><span id="translatedtitle">Ringiculid bubble snails recovered as the <span class="hlt">sister</span> group to sea slugs (Nudipleura).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kano, Yasunori; Brenzinger, Bastian; Nützel, Alexander; Wilson, Nerida G; Schrödl, Michael</p> <p>2016-01-01</p> <p>Euthyneuran gastropods represent one of the most diverse lineages in Mollusca (with over 30,000 species), play significant ecological roles in aquatic and terrestrial environments and affect many aspects of human life. However, our understanding of their evolutionary relationships remains incomplete due to missing data for key phylogenetic lineages. The present study integrates such a neglected, ancient snail family Ringiculidae into a molecular systematics of Euthyneura for the first time, and is supplemented by the first microanatomical data. Surprisingly, both molecular and morphological features present compelling evidence for the common ancestry of ringiculid snails with the highly dissimilar Nudipleura-the most species-rich and well-known taxon of sea slugs (nudibranchs and pleurobranchoids). A new taxon name Ringipleura is proposed here for these long-lost <span class="hlt">sisters</span>, as one of three major euthyneuran clades with late Palaeozoic origins, along with Acteonacea (Acteonoidea + Rissoelloidea) and Tectipleura (Euopisthobranchia + Panpulmonata). The early Euthyneura are suggested to be at least temporary burrowers with a characteristic 'bubble' shell, hypertrophied foot and headshield as exemplified by many extant subtaxa with an infaunal mode of life, while the expansion of the mantle might have triggered the explosive Mesozoic radiation of the clade into diverse ecological niches. PMID:27498754</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26970083','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26970083"><span id="translatedtitle">A high rate of telomeric <span class="hlt">sister</span> chromatid exchange occurs in chronic lymphocytic leukaemia B-cells.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Medves, Sandrine; Auchter, Morgan; Chambeau, Laetitia; Gazzo, Sophie; Poncet, Delphine; Grangier, Blandine; Verney, Aurélie; Moussay, Etienne; Ammerlaan, Wim; Brisou, Gabriel; Morjani, Hamid; Géli, Vincent; Palissot, Valérie; Berchem, Guy; Salles, Gilles; Wenner, Thomas</p> <p>2016-07-01</p> <p>Cancer cells protect their telomere ends from erosion through reactivation of telomerase or by using the Alternative Lengthening of Telomere (ALT) mechanism that depends on homologous recombination. Chronic lymphocytic leukaemia (CLL) B cells are characterized by almost no telomerase activity, shelterin deregulation and telomere fusions. To characterize telomeric maintenance mechanisms in B-CLL patients, we measured their telomere length, telomerase expression and the main hallmarks of the ALT activity i.e. C-circle concentration, an extra-chromosomal telomere repeat (ECTR), and the level of telomeric <span class="hlt">sister</span> chromatid exchange (T-SCE) rate. Patients showed relative homogenous telomere length although almost no TERT transcript and nearly no C-circle were evidenced. Nevertheless, compared with normal B cells, B-CLL cells showed an increase in T-SCE rate that was correlated with a strong down-regulation of the topoisomerase III alpha (TOP3A) expression, involved in the dissolution of Holliday Junctions (HJ), together with an increased expression of SLX1A, SLX4, MUS81 and GEN1, involved in the resolution of HJ. Altogether, our results suggest that the telomere maintenance mechanism of B-CLL cells do not preferentially use telomerase or ALT. Rather, the rupture of the dissolvasome/resolvasome balance may increase telomere shuffling that could homogenize telomere length, slowing telomere erosion in this disease. PMID:26970083</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24852491','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24852491"><span id="translatedtitle">Health assessment of gasoline and fuel oxygenate vapors: micronucleus and <span class="hlt">sister</span> chromatid exchange evaluations.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schreiner, Ceinwen A; Hoffman, Gary M; Gudi, Ramadevi; Clark, Charles R</p> <p>2014-11-01</p> <p>Micronucleus and <span class="hlt">sister</span> chromatid exchange (SCE) tests were performed for vapor condensate of baseline gasoline (BGVC), or gasoline with oxygenates, methyl tert-butyl ether (G/MTBE), ethyl tert butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), t-butyl alcohol (TBA), or ethanol (G/EtOH). Sprague Dawley rats (the same 5/sex/group for both endpoints) were exposed to 0, 2000, 10,000, or 20,000mg/m(3) of each condensate, 6h/day, 5days/week over 4weeks. Positive controls (5/sex/test) were given cyclophosphamide IP, 24h prior to sacrifice at 5mg/kg (SCE test) and 40mg/kg (micronucleus test). Blood was collected from the abdominal aorta for the SCE test and femurs removed for the micronucleus test. Blood cell cultures were treated with 5μg/ml bromodeoxyuridine (BrdU) for SCE evaluation. No significant increases in micronucleated immature erythrocytes were observed for any test material. Statistically significant increases in SCE were observed in rats given BGVC alone or in female rats given G/MTBE. G/TAME induced increased SCE in both sexes at the highest dose only. Although DNA perturbation was observed for several samples, DNA damage was not expressed as increased micronuclei in bone marrow cells. Inclusion of oxygenates in gasoline did not increase the effects of gasoline alone or produce a cytogenetic hazard. PMID:24852491</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4198028','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4198028"><span id="translatedtitle">Meiotic cohesin STAG3 is required for chromosome axis formation and <span class="hlt">sister</span> chromatid cohesion</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Winters, Tristan; McNicoll, Francois; Jessberger, Rolf</p> <p>2014-01-01</p> <p>The cohesin complex is essential for mitosis and meiosis. The specific meiotic roles of individual cohesin proteins are incompletely understood. We report in vivo functions of the only meiosis-specific STAG component of cohesin, STAG3. Newly generated STAG3-deficient mice of both sexes are sterile with meiotic arrest. In these mice, meiotic chromosome architecture is severely disrupted as no bona fide axial elements (AE) form and homologous chromosomes do not synapse. Axial element protein SYCP3 forms dot-like structures, many partially overlapping with centromeres. Asynapsis marker HORMAD1 is diffusely distributed throughout the chromatin, and SYCP1, which normally marks synapsed axes, is largely absent. Centromeric and telomeric <span class="hlt">sister</span> chromatid cohesion are impaired. Centromere and telomere clustering occurs in the absence of STAG3, and telomere structure is not severely affected. Other cohesin proteins are present, localize throughout the STAG3-devoid chromatin, and form complexes with cohesin SMC1β. No other deficiency in a single meiosis-specific cohesin causes a phenotype as drastic as STAG3 deficiency. STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin. PMID:24797474</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2259264','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2259264"><span id="translatedtitle">The effects of boric acid on <span class="hlt">sister</span> chromatid exchanges and chromosome aberrations in cultured human lymphocytes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Arslan, Mehmet; Topaktas, Mehmet</p> <p>2007-01-01</p> <p>The aim of this study was to determine the possible genotoxic effects of boric acid (BA) (E284), which is used as an antimicrobial agent in food, by using <span class="hlt">sister</span> chromatid exchange (SCEs) and chromosome aberration (CAs) tests in human peripheral lymphocytes. The human lymphocytes were treated with 400, 600, 800, and 1000 μg/mL concentrations of BA dissolved in dimethyl sulfoxide (DMSO), for 24 h and 48 h treatment periods. BA did not increase the SCEs for all the concentrations and treatment periods when compared to control and solvent control (DMSO). BA induced structural and total CAs at all the tested concentrations for 24 and 48 h treatment periods. The induction of the total CAs was dose dependent for the 24 h treatment period. However, BA did not cause numerical CAs. BA showed a cytotoxic effect by decreasing the replication index (RI) and mitotic index (MI). BA decreased the MI in a dose-dependent manner for the 24 h treatment period. PMID:19002846</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/5462220','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/5462220"><span id="translatedtitle">Induction of <span class="hlt">sister</span> chromatid exchanges and bacterial revertants by organic extracts of airborne particles. [Humans</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Lockard, J.M.; Viau, C.J.; Lee-Stephens, C.; Caldwell, J.C.; Wojciechowski, J.P.; Enoch, H.G.; Sabharwal, P.S.</p> <p>1981-01-01</p> <p>The genotoxicities of organic extracts of airborne particles have been studied extensively in the Salmonella/mammalian microsome (Ames) test, but in few other bioassays. In these studies, we tested benzene-acetone extracts of particulate pollutants collected in Lexington, Kentucky, for capacity to induce increases in <span class="hlt">sister</span> chromatid exchanges (SCE) in human lumphocytes and V79 cells, as well as in the Ames assay. Extracts induced linear dose-related increases in SCE in human lumphocytes and in bacterial revertants.However, variable responses were observed in SCE assays in V79 cells with and without activation by rat liver S9 or feeder layers of irradiated Syrian hamster fetal cells. We conclude that the SCE assay in human lumphocytes may be a useful indicator of the potential risks to humans of airborne particulate pollutants, as it utilizes human cells recently taken from the host, is rapid and economical, and requires small quantities of test materials. However, thorough studies of the quantitative relationships between SCE induction and mutagenicity in human cells are needed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21614815','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21614815"><span id="translatedtitle">[Near-<span class="hlt">death</span> experiences].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Bonilla, Ernesto</p> <p>2011-03-01</p> <p>Near-<span class="hlt">death</span> experiences (NDE) are lucid events that take place when a person is so physically compromised that he would die if its condition does not improve. He is unconscious, without heartbeats and breath, and with a flat-line electroencephalogram. NDE may include some of the following elements: Out of the body experiences or separation of consciousness from the physical body, increase in sensory perception and intense emotions, travel into or through a tunnel, encounter with a brilliant light and mystical beings, deceased relatives or friends, a sense of alteration in time and space, visualization of unworldly realms and a special knowledge, encounter with a barrier or boundary, and a return to the body, either voluntary or involuntary. The fact that children NDE are similar to adult NDE is an evidence that these experiences are real and not due to pre-existing beliefs, cultural influences or previous experiences in the present life. The characteristics of NDE are similar worldwide. No evidence supports the physiological, psychological, neurochemical, and neuroanatomical hypothesis proposed to explain the NDE. Multifactorial models, based on the combination of all of them (brain anoxia or hypoxia, release of serotonin, endorphins and ketamine-like compounds) have also been proposed. Although physiological, psychological, and socio-cultural factors could interact in the NDE, the hypothesis proposed consist essentially in unsupported speculations about what might be happening during the NDE. PMID:21614815</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=defensive+AND+strategy&pg=7&id=EJ301161','ERIC'); return false;" href="http://eric.ed.gov/?q=defensive+AND+strategy&pg=7&id=EJ301161"><span id="translatedtitle"><span class="hlt">Death</span> Concerns in Differential Levels of Consciousness as Functions of Defense Strategy and Religious Belief.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rosenheim, Eliyahu; Muchnik, Benjamin</p> <p>1985-01-01</p> <p>Explores the relationships between defensive style (repression-sensitization) and Jewish religiosity and <span class="hlt">death</span> concerns in the context of differential levels of awareness of 64 Israeli students. Found that the personality attribute of defensive style was <span class="hlt">linked</span> systematically to <span class="hlt">death</span> concern at all levels of consciousness. Religiosity was less…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7374664','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7374664"><span id="translatedtitle">Effect of lead chromate on chromosome aberration, <span class="hlt">sister</span>-chromatid exchange and DNA damage in mammalian cells in vitro.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Douglas, G R; Bell, R D; Grant, C E; Wytsma, J M; Bora, K C</p> <p>1980-02-01</p> <p>Possible mutagenic activity of lead chromate in mammalian cells was studied using assays for chromosome aberrations and <span class="hlt">sister</span>-chromatid exchanges in cultured human lymphocytes, and DNA fragmentation as detected by alkaline-sucrose gradient sedimentation in cultured Chinese hamster ovary (CHO) cells. Lead chromate caused dose-related increases in chromosome aberration and <span class="hlt">sister</span>-chromatid exchange in human lymphocytes. No increase in DNA damage was observed in CHO cells, possibly due to the relative insensitivity of the CHO cells and the limited solubility of lead chromate in tissue culture medium. The mutagenicity of lead chromate in human lymphocytes appears to be entirely due to the chromate ion since chromosome aberrations were induced by potassium chromate but not lead chloride. PMID:7374664</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_25 --> <center> <div class="footer-extlink text-muted"><small>Some links on this page may take you to non-federal websites. Their policies may differ from this site.</small> </div> </center> <div id="footer-wrapper"> <div class="footer-content"> <div id="footerOSTI" class=""> <div class="row"> <div class="col-md-4 text-center col-md-push-4 footer-content-center"><small><a href="http://www.science.gov/disclaimer.html">Privacy and Security</a></small> <div class="visible-sm visible-xs push_footer"></div> </div> <div class="col-md-4 text-center col-md-pull-4 footer-content-left"> <img src="http://www.osti.gov/images/DOE_SC31.png" alt="U.S. Department of Energy" usemap="#doe" height="31" width="177"><map style="display:none;" name="doe" id="doe"><area shape="rect" coords="1,3,107,30" href="http://www.energy.gov" alt="U.S. Deparment of Energy"><area shape="rect" coords="114,3,165,30" href="http://www.science.energy.gov" alt="Office of Science"></map> <a ref="http://www.osti.gov" style="margin-left: 15px;"><img src="http://www.osti.gov/images/footerimages/ostigov53.png" alt="Office of Scientific and Technical Information" height="31" width="53"></a> <div class="visible-sm visible-xs push_footer"></div> </div> <div class="col-md-4 text-center footer-content-right"> <a href="http://www.osti.gov/nle"><img src="http://www.osti.gov/images/footerimages/NLElogo31.png" alt="National Library of Energy" height="31" width="79"></a> <a href="http://www.science.gov"><img src="http://www.osti.gov/images/footerimages/scigov77.png" alt="science.gov" height="31" width="98"></a> <a href="http://worldwidescience.org"><img src="http://www.osti.gov/images/footerimages/wws82.png" alt="WorldWideScience.org" height="31" width="90"></a> </div> </div> </div> </div> </div> <p><br></p> </div><!-- container --> </body> </html>