Asymptotic behavior of degenerate logistic equations
NASA Astrophysics Data System (ADS)
Arrieta, José M.; Pardo, Rosa; Rodríguez-Bernal, Aníbal
2015-12-01
We analyze the asymptotic behavior of positive solutions of parabolic equations with a class of degenerate logistic nonlinearities of the type λu - n (x)uρ. An important characteristic of this work is that the region where the logistic term n (ṡ) vanishes, that is K0 = { x : n (x) = 0 }, may be non-smooth. We analyze conditions on λ, ρ, n (ṡ) and K0 guaranteeing that the solution starting at a positive initial condition remains bounded or blows up as time goes to infinity. The asymptotic behavior may not be the same in different parts of K0.
Hypocoercivity of linear degenerately dissipative kinetic equations
NASA Astrophysics Data System (ADS)
Duan, Renjun
2011-08-01
In this paper we develop a general approach of studying the hypocoercivity for a class of linear kinetic equations with both transport and degenerately dissipative terms. As concrete examples, the relaxation operator, Fokker-Planck operator and linearized Boltzmann operator are considered when the spatial domain takes the whole space or torus and when there is a confining force or not. The key part of the developed approach is to construct some equivalent temporal energy functionals for obtaining time rates of the solution trending towards equilibrium in some Hilbert spaces. The result in the case of the linear Boltzmann equation with confining forces is new. The proof mainly makes use of the macro-micro decomposition combined with Kawashima's argument on dissipation of the hyperbolic-parabolic system. At the end, a Korn-type inequality with probability measure is provided to deal with dissipation of momentum components.
Linear stochastic degenerate Sobolev equations and applications†
NASA Astrophysics Data System (ADS)
Liaskos, Konstantinos B.; Pantelous, Athanasios A.; Stratis, Ioannis G.
2015-12-01
In this paper, a general class of linear stochastic degenerate Sobolev equations with additive noise is considered. This class of systems is the infinite-dimensional analogue of linear descriptor systems in finite dimensions. Under appropriate assumptions, the mild and strong well-posedness for the initial value problem are studied using elements of the semigroup theory and properties of the stochastic convolution. The final value problem is also examined and it is proved that this is uniquely strongly solvable and the solution is continuously dependent on the final data. Based on the results of the forward and backward problem, the conditions for the exact controllability are investigated for a special but important class of these equations. The abstract results are illustrated by applications in complex media electromagnetics, in the one-dimensional stochastic Dirac equation in the non-relativistic limit and in a potential application in input-output analysis in economics. Dedicated to Professor Grigoris Kalogeropoulos on the occasion of his seventieth birthday.
Anisotropic uniqueness classes for a degenerate parabolic equation
Vil'danova, V F; Mukminov, F Kh
2013-11-30
Anisotropic uniqueness classes of Tacklind type are identified for a degenerate linear parabolic equation of the second order in an unbounded domain. The Cauchy problem and mixed problems with boundary conditions of the first and third type are considered. Bibliography: 18 titles.
Electromagnetic wave equations for relativistically degenerate quantum magnetoplasmas.
Masood, Waqas; Eliasson, Bengt; Shukla, Padma K
2010-06-01
A generalized set of nonlinear electromagnetic quantum hydrodynamic (QHD) equations is derived for a magnetized quantum plasma, including collisional, electron spin- 1/2, and relativistically degenerate electron pressure effects that are relevant for dense astrophysical systems, such as white dwarfs. For illustrative purposes, linear dispersion relations are derived for one-dimensional magnetoacoustic waves for a collisionless nonrelativistic degenerate gas in the presence of the electron spin- 1/2 contribution and for magnetoacoustic waves in a plasma containing relativistically degenerate electrons. It is found that both the spin and relativistic degeneracy at high densities tend to slow down the magnetoacoustic wave due to the Pauli paramagnetic effect and relativistic electron mass increase. The present study outlines the theoretical framework for the investigation of linear and nonlinear behaviors of electromagnetic waves in dense astrophysical systems. The results are applied to calculate the magnetoacoustic speeds for both the nonrelativistic and relativistic electron degeneracy cases typical for white dwarf stars. PMID:20866534
NASA Technical Reports Server (NTRS)
Cooke, K. L.; Meyer, K. R.
1966-01-01
Extension of problem of singular perturbation for linear scalar constant coefficient differential- difference equation with single retardation to several retardations, noting degenerate equation solution
Exponential Mixing of the 3D Stochastic Navier-Stokes Equations Driven by Mildly Degenerate Noises
Albeverio, Sergio; Debussche, Arnaud; Xu Lihu
2012-10-15
We prove the strong Feller property and exponential mixing for 3D stochastic Navier-Stokes equation driven by mildly degenerate noises (i.e. all but finitely many Fourier modes being forced) via a Kolmogorov equation approach.
Weak Solutions for the Cahn-Hilliard Equation with Degenerate Mobility
NASA Astrophysics Data System (ADS)
Dai, Shibin; Du, Qiang
2016-03-01
In this paper, we study the well-posedness of Cahn-Hilliard equations with degenerate phase-dependent diffusion mobility. We consider a popular form of the equations which has been used in phase field simulations of phase separation and microstructure evolution in binary systems. We define a notion of weak solutions for the nonlinear equation. The existence of such solutions is obtained by considering the limits of Cahn-Hilliard equations with non-degenerate mobilities.
NASA Astrophysics Data System (ADS)
Wang, Zhi-Cheng; Bu, Zhen-Hui
2016-04-01
This paper is concerned with nonplanar traveling fronts in reaction-diffusion equations with combustion nonlinearity and degenerate Fisher-KPP nonlinearity. Our study contains two parts: in the first part we establish the existence of traveling fronts of pyramidal shape in R3, and in the second part we establish the existence and stability of V-shaped traveling fronts in R2.
NASA Astrophysics Data System (ADS)
Tarhini, Rana
2015-12-01
In this paper, we study a nonlocal degenerate parabolic equation of order α + 2 for α ∈ (0, 2). The equation is a generalization of the one arising in the modeling of hydraulic fractures studied by Imbert and Mellet in 2011. Using the same approach, we prove the existence of solutions for this equation for 0 < α < 2 and for nonnegative initial data satisfying appropriate assumptions. The main difference is the compactness results due to different Sobolev embeddings. Furthermore, for α > 1, we construct a nonnegative solution for nonnegative initial data under weaker assumptions.
NASA Astrophysics Data System (ADS)
LeBlanc, Victor G.
2016-02-01
In this paper, we study degenerate Hopf bifurcations in a class of parametrized retarded functional differential equations. Specifically, we are interested in the case where the eigenvalue crossing condition of the classical Hopf bifurcation theorem is violated. Our approach is based on center manifold reduction and Poincaré-Birkhoff normal forms, and a singularity theoretical classification of this degenerate Hopf bifurcation. Our results are applied to a recently developed SIS model incorporating a delayed behavioral response. We show the phenomenon of endemic bubbles, which is characterized by a branch of periodic solutions which bifurcates from the endemic equilibrium at some value of the basic reproduction number R_0, and then reconnects to the endemic equilibrium at a larger value of R_0, originates in a codimension-two organizing center where the eigenvalue crossing condition for the Hopf bifurcation theorem is violated.
On Classical Solutions to 2D Shallow Water Equations with Degenerate Viscosities
NASA Astrophysics Data System (ADS)
Li, Yachun; Pan, Ronghua; Zhu, Shengguo
2016-07-01
2D shallow water equations have degenerate viscosities proportional to surface height, which vanishes in many physical considerations, say, when the initial total mass, or energy are finite. Such a degeneracy is a highly challenging obstacle for development of well-posedness theory, even local-in-time theory remains open for a long time. In this paper, we will address this open problem with some new perspectives, independent of the celebrated BD-entropy (Bresch et al in Commun Math Phys 238:211-223, 2003, Commun Part Differ Eqs 28:843-868, 2003, Analysis and Simulation of Fluid Dynamics, 2007). After exploring some interesting structures of most models of 2D shallow water equations, we introduced a proper notion of solution class, called regular solutions, and identified a class of initial data with finite total mass and energy, and established the local-in-time well-posedness of this class of smooth solutions. The theory is applicable to most relatively physical shallow water models, broader than those with BD-entropy structures. We remark that our theory is on the local strong solutions, while the BD entropy is an essential tool for the global weak solutions. Later, a Beale-Kato-Majda type blow-up criterion is also established. This paper is mainly based on our early preprint (Li et al. in 2D compressible Navier-Stokes equations with degenerate viscosities and far field vacuum, preprint. arXiv:1407.8471, 2014).
Quasi-regular solutions to a class of 3D degenerating hyperbolic equations
NASA Astrophysics Data System (ADS)
Hristov, T. D.; Popivanov, N. I.; Schneider, M.
2012-11-01
In the fifties M. Protter stated new three-dimensional (3D) boundary value problems (BVP) for mixed type equations of first kind. For hyperbolic-elliptic equations they are multidimensional analogue of the classical two-dimensional (2D) Morawetz-Guderley transonic problem. Up to now, in this case, not a single example of nontrivial solution to the new problem, neither a general existence result is known. The difficulties appear even for BVP in the hyperbolic part of the domain, that were formulated by Protter for weakly hyperbolic equations. In that case the Protter problems are 3D analogues of the plane Darboux or Cauchy-Goursat problems. It is interesting that in contrast to the planar problems the new 3D problems are strongly ill-posed. Some of the Protter problems for degenerating hyperbolic equation without lower order terms or even for the usual wave equation have infinite-dimensional kernels. Therefore there are infinitely many orthogonality conditions for classical solvability of their adjiont problems. So it is interesting to obtain results for uniqueness of solutions adding first order terms in the equation. In the present paper we do this and find conditions for coefficients under which we prove uniqueness of quasi-regular solutions to the Protter problems.
A-priori analysis and the finite element method for a class of degenerate elliptic equations
NASA Astrophysics Data System (ADS)
Li, Hengguang
2009-06-01
Consider the degenerate elliptic operator mathcal{L_delta} := -partial^2_x-frac{delta^2}{x^2}partial^2_y on Omega:= (0, 1)times(0, l) , for delta>0, l>0 . We prove well-posedness and regularity results for the degenerate elliptic equation mathcal{L_delta} u=f in Omega , u\\vert _{partialOmega}=0 using weighted Sobolev spaces mathcal{K}^m_a . In particular, by a proper choice of the parameters in the weighted Sobolev spaces mathcal{K}^m_a , we establish the existence and uniqueness of the solution. In addition, we show that there is no loss of mathcal{K}^m_a -regularity for the solution of the equation. We then provide an explicit construction of a sequence of finite dimensional subspaces V_n for the finite element method, such that the optimal convergence rate is attained for the finite element solution u_nin V_n , i.e., \\vert\\vert u-u_n\\vert\\vert _{H^1(Omega)}leq C{dim}(V_n)^{-frac{m}{2}}\\vert\\vert f\\vert\\vert _{H^{m-1}(Omega)} with C independent of f and n .
Truncation model in the triple-degenerate derivative nonlinear Schroedinger equation
Sanchez-Arriaga, G.; Hada, T.; Nariyuki, Y.
2009-04-15
The triple-degenerate derivative nonlinear Schroedinger (TDNLS) system modified with resistive wave damping and growth is truncated to study the coherent coupling of four waves, three Alfven and one acoustic, near resonance. In the conservative case, the truncation equations derive from a time independent Hamiltonian function with two degrees of freedom. Using a Poincare map analysis, two parameters regimes are explored. In the first regime we check how the modulational instability of the TDNLS system affects to the dynamics of the truncation model, while in the second one the exact triple degenerated case is discussed. In the dissipative case, the truncation model gives rise to a six dimensional flow with five free parameters. Computing some bifurcation diagrams the dependence with the sound to Alfven velocity ratio as well as the Alfven modes involved in the truncation is analyzed. The system exhibits a wealth of dynamics including chaotic attractor, several kinds of bifurcations, and crises. The truncation model was compared to numerical integrations of the TDNLS system.
NASA Technical Reports Server (NTRS)
Cacio, Emanuela; Cohn, Stephen E.; Spigler, Renato
2011-01-01
A numerical method is devised to solve a class of linear boundary-value problems for one-dimensional parabolic equations degenerate at the boundaries. Feller theory, which classifies the nature of the boundary points, is used to decide whether boundary conditions are needed to ensure uniqueness, and, if so, which ones they are. The algorithm is based on a suitable preconditioned implicit finite-difference scheme, grid, and treatment of the boundary data. Second-order accuracy, unconditional stability, and unconditional convergence of solutions of the finite-difference scheme to a constant as the time-step index tends to infinity are further properties of the method. Several examples, pertaining to financial mathematics, physics, and genetics, are presented for the purpose of illustration.
Kedziora, David J; Ankiewicz, Adrian; Akhmediev, Nail
2012-06-01
We present an explicit analytic form for the two-breather solution of the nonlinear Schrödinger equation with imaginary eigenvalues. It describes various nonlinear combinations of Akhmediev breathers and Kuznetsov-Ma solitons. The degenerate case, when the two eigenvalues coincide, is quite involved. The standard inverse scattering technique does not generally provide an answer to this scenario. We show here that the solution can still be found as a special limit of the general second-order expression and appears as a mixture of polynomials with trigonometric and hyperbolic functions. A further restriction of this particular case, where the two eigenvalues are equal to i, produces the second-order rogue wave with two free parameters considered as differential shifts. The illustrations reveal a precarious dependence of wave profile on the degenerate eigenvalues and differential shifts. Thus we establish a hierarchy of second-order solutions, revealing the interrelated nature of the general case, the rogue wave, and the degenerate breathers. PMID:23005231
The multigrid algorithm applied to a degenerate equation: A convergence analysis
NASA Astrophysics Data System (ADS)
Almendral Vázquez, Ariel; Fredrik Nielsen, Bjørn
2009-03-01
In this paper we analyze the convergence properties of the Multigrid Method applied to the Black-Scholes differential equation arising in mathematical finance. We prove, for the discretized single-asset Black-Scholes equation, that the multigrid V-cycle possesses optimal convergence properties. Furthermore, through a series of numerical experiments we test the performance of the method for single-asset option problems. Throughout the paper we focus on models of European options.
NASA Astrophysics Data System (ADS)
Abedian, Rooholah; Adibi, Hojatollah; Dehghan, Mehdi
2013-08-01
In this paper, we propose a new WENO finite difference procedure for nonlinear degenerate parabolic equations which may contain discontinuous solutions. Our scheme is based on the method of lines, with a high-order accurate conservative approximation to each of the diffusion terms based on an idea that has been recently presented by Liu et al. [Y. Liu, C.-W. Shu, M. Zhang, High order finite difference WENO schemes for non-linear degenerate parabolic equations, SIAM J. Sci. Comput. 33 (2011) 939-965]. Our scheme tries to circumvent the negative ideal weights that appear when applying the standard WENO idea, as is done in Liu et al. (2011) [13]. In one-dimensional case, first we obtain an optimum polynomial on a six-points stencil. This optimum polynomial is sixth-order accurate in regions of smoothness. Then, we consider this optimum polynomial as a symmetric and convex combination of four polynomials with ideal weights. Following the methodology of the classic WENO procedure, then we calculate the non-oscillatory weights with the ideal weights. Numerical examples are provided to demonstrate the resolution power and accuracy of the scheme. Finally, the new method is extended to multi-dimensional problems by dimension-by-dimension approach. More examples of multi-dimension problems are presented to show that our method remains non-oscillatory while giving good resolution of discontinuities. Finally, we would like to mention that this paper combines and extends the techniques proposed in [13] and Levy et al. (2000) [24].
Solutions to a degenerate system of parabolic equations from marine biology.
Wörz-Busekros, A
1976-11-25
A system of parabolic and ordinary differential equations ut = a2 uxx + F(u,v,w), vt = a2 vxx + G(u,v,w), wx = -k(u) w is studied which has been proposed by Radach and Maier-Reimer for the dynamics of phytoplankton and nutrient in dependence of light intensity. It is shown that there is a unique solution to this system satisfying given initial and boundary conditions. The solution depends continuously on the data. For specific nonlinearities F, G, and k bounds for the solutions are given. PMID:1022838
Geredeli, Pelin G.; Webster, Justin T.
2013-12-15
We analyze the convergence to equilibrium of solutions to the nonlinear Berger plate evolution equation in the presence of localized interior damping (also referred to as geometrically constrained damping). Utilizing the results in (Geredeli et al. in J. Differ. Equ. 254:1193–1229, 2013), we have that any trajectory converges to the set of stationary points N . Employing standard assumptions from the theory of nonlinear unstable dynamics on the set N , we obtain the rate of convergence to an equilibrium. The critical issue in the proof of convergence to equilibria is a unique continuation property (which we prove for the Berger evolution) that provides a gradient structure for the dynamics. We also consider the more involved von Karman evolution, and show that the same results hold assuming a unique continuation property for solutions, which is presently a challenging open problem.
NASA Astrophysics Data System (ADS)
Zhou, Jun; Mu, Chunlai
2011-02-01
This paper deals with the following weakly coupled degenerate and singular parabolic equations with localized source u_t-(x^α u_x)_x=u^m(x_0(t),t)v^n(x_0(t),t),quad v_t-(x^β v_x)_x=v^p(x_0(t),t)u^q(x_0(t),t) in (0, a) × (0, T) with homogeneous Dirichlet boundary conditions, where {x_0(t):{R}^+→(0,a)} is Hölder continuous. T ≤ ∞, a > 0 be constants, m, n, p, q are positive real numbers and {α,βin[0,2)}. The existence of a unique classical non-negative solution is established and the sufficient conditions for the solution that exists globally or blows up in finite time are obtained. Furthermore, under certain conditions, it is proved that the blow-up set of the blowing-up solution is any closed subset of the interval (0, a). Furthermore, we also obtain the blow-up rate under the condition α = β.
Degtyarev, Sergey P
2010-09-02
The first initial-boundary problem for second-order parabolic and degenerate parabolic equations is investigated in a domain with a conical or angular point. The means of attack is already known and uses weighted classes of smooth or integrable functions. Sufficient conditions for a unique solution to exist and for coercive estimates for the solution to be obtained are formulated in terms of the angular measure of the solid angle and the exponent of the weight. It is also shown that if these conditions fail to hold, then the parabolic problem has elliptic properties, that is, it can have a nonzero kernel or can be nonsolvable, and, in the latter case, it is not even a Fredholm problem. A parabolic equation and an equation with some degeneracy or a singularity at a conical point are considered. Bibliography: 49 titles.
Bertola, Marco
2015-06-15
Two-phase solutions of focusing NLS equation are classically constructed out of an appropriate Riemann surface of genus two and expressed in terms of the corresponding theta-function. We show here that in a certain limiting regime, such solutions reduce to some elementary ones called “Solitons on unstable condensate.” This degeneration turns out to be conveniently studied by means of basic tools from the theory of Riemann-Hilbert problems. In particular, no acquaintance with Riemann surfaces and theta-function is required for such analysis.
MedlinePlus Videos and Cool Tools
... at the center of the field of vision. Macular degeneration results from a partial breakdown of the insulating ... choroid layer of blood vessels behind the retina. Macular degeneration results in the loss of central vision only.
... Degeneration? Cerebellar degeneration is a process in which neurons in the cerebellum - the area of the brain ... proteins that are necessary for the survival of neurons. Associated diseases: Diseases that are specific to the ...
NASA Technical Reports Server (NTRS)
Thorne, K. S.; Zytkow, A. N.
1976-01-01
The general relativistic equations of stellar structure and evolution are reformulated in a notation which makes easy contact with Newtonian theory. Also, a general relativistic version of the mixing-length formalism for convection is presented. Finally, it is argued that in previous work on spherical systems general relativity theorists have identified the wrong quantity as "total mass-energy inside radius r."
NASA Astrophysics Data System (ADS)
Bobodzhanov, A. A.; Safonov, V. F.
2016-04-01
We consider an algorithm for constructing asymptotic solutions regularized in the sense of Lomov (see [1], [2]). We show that such problems can be reduced to integro-differential equations with inverse time. But in contrast to known papers devoted to this topic (see, for example, [3]), in this paper we study a fundamentally new case, which is characterized by the absence, in the differential part, of a linear operator that isolates, in the asymptotics of the solution, constituents described by boundary functions and by the fact that the integral operator has kernel with diagonal degeneration of high order. Furthermore, the spectrum of the regularization operator A(t) (see below) may contain purely imaginary eigenvalues, which causes difficulties in the application of the methods of construction of asymptotic solutions proposed in the monograph [3]. Based on an analysis of the principal term of the asymptotics, we isolate a class of inhomogeneities and initial data for which the exact solution of the original problem tends to the limit solution (as \\varepsilon\\to+0) on the entire time interval under consideration, also including a boundary-layer zone (that is, we solve the so-called initialization problem). The paper is of a theoretical nature and is designed to lead to a greater understanding of the problems in the theory of singular perturbations. There may be applications in various applied areas where models described by integro-differential equations are used (for example, in elasticity theory, the theory of electrical circuits, and so on).
The truncation model of the derivative nonlinear Schroedinger equation
Sanchez-Arriaga, G.; Hada, T.; Nariyuki, Y.
2009-04-15
The derivative nonlinear Schroedinger (DNLS) equation is explored using a truncation model with three resonant traveling waves. In the conservative case, the system derives from a time-independent Hamiltonian function with only one degree of freedom and the solutions can be written using elliptic functions. In spite of its low dimensional order, the truncation model preserves some features from the DNLS equation. In particular, the modulational instability criterion fits with the existence of two hyperbolic fixed points joined by a heteroclinic orbit that forces the exchange of energy between the three waves. On the other hand, numerical integrations of the DNLS equation show that the truncation model fails when wave energy is increased or left-hand polarized modulational unstable modes are present. When dissipative and growth terms are added the system exhibits a very complex dynamics including appearance of several attractors, period doubling bifurcations leading to chaos as well as other nonlinear phenomenon. In this case, the validity of the truncation model depends on the strength of the dissipation and the kind of attractor investigated.
Breather management in the derivative nonlinear Schrödinger equation with variable coefficients
Zhong, Wei-Ping; Belić, Milivoj; Malomed, Boris A.; Huang, Tingwen
2015-04-15
We investigate breather solutions of the generalized derivative nonlinear Schrödinger (DNLS) equation with variable coefficients, which is used in the description of femtosecond optical pulses in inhomogeneous media. The solutions are constructed by means of the similarity transformation, which reduces a particular form of the generalized DNLS equation into the standard one, with constant coefficients. Examples of bright and dark breathers of different orders, that ride on finite backgrounds and may be related to rogue waves, are presented. - Highlights: • Exact solutions of a generalized derivative NLS equation are obtained. • The solutions are produced by means of a transformation to the usual integrable equation. • The validity of the solutions is verified by comparing them to numerical counterparts. • Stability of the solutions is checked by means of direct simulations. • The model applies to the propagation of ultrashort pulses in optical media.
NASA Astrophysics Data System (ADS)
Tchinang Tchameu, J. D.; Togueu Motcheyo, A. B.; Tchawoua, C.
2016-09-01
The discrete multi-rogue waves (DMRW) as solution of the discrete nonlinear Schrödinger (DNLS) equation with saturable nonlinearities is studied numerically. These biological rogue waves represent the complex probability amplitude of finding an amide-I vibrational quantum at a site. We observe that the growth in the higher order saturable nonlinearity implies the formation of DMRW including an increase in the short-living DMRW and a decrease in amplitude of the long-living DMRW.
... common early symptom. Dry AMD happens when the light-sensitive cells in the macula slowly break down. Your gradually lose your central vision. A common early symptom is that straight lines appear crooked. Regular comprehensive eye exams can detect macular degeneration before the disease ...
Gibb, W R; Luthert, P J; Marsden, C D
1989-10-01
Three patients with clinical and pathological features of corticobasal degeneration are described. They presented with a progressive disease bearing some clinical resemblance to Steele-Richardson-Olszewski syndrome and displaying some pathological features of Pick's disease. Their illness began at the age of 59 to 66 yrs with focal dystonia and myoclonus of an arm, the 'alien hand' sign, or an akinetic-rigid syndrome. They developed a supranuclear gaze palsy, parkinsonian features and mild cerebellar signs. Two patients showed constructional dyspraxia when using the arms. The duration of disease to death was 4 to 6 yrs. Pathological examination showed frontoparietal atrophy with cortical cell loss, gliosis and Pick cells, but there was no significant hippocampal disease or Pick bodies in this region. There was nerve cell loss and gliosis in the thalamus, lentiform nucleus, subthalamic nucleus, red nucleus, midbrain tegmentum, substantia nigra and locus coeruleus. Neuronal inclusions in the substantia nigra, termed corticobasal inclusions, were reminiscent of the globose neurofibrillary tangle of Steele-Richardson-Olszewski syndrome, and other pale inclusions resembled the pale body of Parkinson's disease, but Lewy bodies and neurofibrillary tangles were generally absent. Some nigral inclusions were similar to those in Pick's disease. Despite some pathological similarities to Pick's disease we suggest that the distribution of nerve cell loss and the corticobasal inclusion are unique to corticobasal degeneration. PMID:2478251
Macular degeneration is a disease of the retina that affects the macula in the back of the eye. ... see fine details. There are two types of macular degeneration, dry and wet. Dry macular degeneration is more ...
Vortex Solutions of the Defocusing Discrete Nonlinear Schroedinger Equation
Cuevas, J.; Kevrekidis, P. G.; Law, K. J. H.
2009-09-09
We consider the existence, stability and dynamical evolution of dark vortex states in the two-dimensional defocusing DNLS equation, a model of interest both to atomic physics and to nonlinear optics. Our considerations are chiefly based on initializing such vortex configurations at the anti-continuum limit of zero coupling between adjacent sites, and continuing them to finite values of the coupling. Discrete defocusing vortices become unstable past a critical coupling strength and, subsequently feature a cascade of alternating stabilization-destabilization windows for any finite lattice.
Solitons in the discrete nonpolynomial Schrödinger equation
NASA Astrophysics Data System (ADS)
Maluckov, Aleksandra; Hadžievski, Ljupčo; Malomed, Boris A.; Salasnich, Luca
2008-07-01
We introduce a species of the discrete nonlinear Schrödinger (DNLS) equation, which is a model for a self-attractive Bose-Einstein condensate confined in a combination of a cigar-shaped trap and deep optical lattice acting in the axial direction. The equation is derived as a discretization of the respective nonlinear nonpolynomial Schrödinger equation. Unlike previously considered varieties of one-dimensional DNLS equations, the present discrete model admits on-site collapse. We find two families of unstaggered on-site-centered discrete solitons, stable and unstable ones, which include, respectively, broad and narrow solitons, their stability exactly complying with the Vakhitov-Kolokolov criterion. Unstable on-site solitons either decay or transform themselves into robust breathers. Intersite-centered unstaggered solitons are unstable to collapse; however, they may be stabilized by the application of a sufficiently strong kick, which turns them into moving localized modes. Persistently moving solitons can be readily created too by the application of the kick to stable on-site unstaggered solitons. In the same model, staggered solitons, which are counterparts of gap solitons in the continuum medium, are possible if the intrinsic nonlinearity is self-repulsive. All on-site staggered solitons are stable, while intersite ones have a small instability region. The staggered solitons are immobile.
Bazalii, B V; Degtyarev, S P
2013-07-31
An elliptic boundary-value problem for second-order equations with nonnegative characteristic form is investigated in the situation when there is a weak degeneracy on the boundary of the domain. A priori estimates are obtained for solutions and the problem is proved to be solvable in some weighted Hölder spaces. Bibliography: 18 titles.
NASA Astrophysics Data System (ADS)
Mikheev, S. A.; Tsvetkov, V. P.
2016-07-01
A system of equations and inequalities that allows one to determine the constraints on central density ρ c and the chemical composition, which is governed by parameter μ e , of the white dwarf RX J0648.0- 4418 with a record short period of rotation T = 13.18s and mass m = (1.28 ± 0.05) m⊙, has been derived. The analysis of numerical solutions of this system reveal a complex dependence of μ e on ρ c . The intervals of variation of μ e and ρ c are as follows: 1.09 ≤ μ e ≤ 1.21 and 9.04 ≤ μ e /ρ0 ≤ 103 (ρ0 = 0.98 × 106 g/cm3). This range of μ e values suggests that the white dwarf RX J0648.0-4418 is not made of pure hydrogen and should contain 9-21% of heavy elements. Calculations have been performed with the equation of state of an ideal degenerate electron gas. Approximate analytic expressions (with an accuracy of 10-3) for the minimum period T min and mass m of the white dwarf are obtained. It is demonstrated that the white-dwarf mass is almost doubled (compared to the case of no rotation at a fixed central density) as period T approaches T min.
Macular Degeneration: An Overview.
ERIC Educational Resources Information Center
Chalifoux, L. M.
1991-01-01
This article presents information on macular degeneration for professionals helping persons with this disease adjust to their visual loss. It covers types of macular degeneration, the etiology of the disease, and its treatment. Also considered are psychosocial problems and other difficulties that persons with age-related macular degeneration face.…
Dispersion relations in weakly degenerate plasmas
NASA Astrophysics Data System (ADS)
Rocchi, F.; Molinari, V. G.; Mostacci, D.; Sumini, M.
2001-06-01
From a quantum mechanical point of view, electrons in laser produced plasmas can be regarded as weakly degenerate. For instance, for a plasma with electron density of 10 22 cm -3 and electron temperature of 1 eV, Sommerfeld's parameter is between 1 and 2. Under these conditions the usual dispersion relations for waves in plasmas need be corrected to account for degeneracy. In the present work, starting from the transport equation with a simplified version of the Boltzmann-Uehling-Uhlenbeck collision kernel the propagation of waves impinging on a plasma with weakly degenerate electrons is investigated and dispersion relations accounting for degeneracy are derived. These dispersion relations give the classical ones in the limit for Sommerfeld's parameter approaching zero. A shift of the wavenumber value and a non-collisional damping due to degeneracy effects are predicted which render a weakly degenerate plasma more opaque to radiation than a non-degenerate one.
Intervertebral Disc Degeneration
Rannou, François; Lee, Tzong-Shyuan; Zhou, Rui-Hai; Chin, Jennie; Lotz, Jeffrey C.; Mayoux-Benhamou, Marie-Anne; Barbet, Jacques Patrick; Chevrot, Alain; Shyy, John Y.-J.
2004-01-01
Degeneration of the intervertebral disk (IVD) is a major pathological process implicated in low back pain and is a prerequisite to disk herniation. Although mechanical stress is an important modulator of the degeneration, the underlying molecular mechanism remains unclear. The association of human IVD degeneration, assessed by magnetic resonance imaging, with annulus fibrosus cell apoptosis and anti-cytochrome c staining revealed that the activation of the mitochondria-dependent apoptosome was a major event in the degeneration process. Mouse models of IVD degeneration were used to investigate the role of the mechanical stress in this process. The application of mechanical overload (1.3 MPa) for 24 hours induced annulus fibrosus cell apoptosis and led to severe degeneration of the mouse disks. Immunostaining revealed cytochrome c release but not Fas-L generation. The role of the caspase-9-dependent mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload was investigated further with the use of cultured rabbit IVD cells in a stretch device. Mechanical overload (15% area change) induced apoptosis with increased caspase-9 activity and decreased mitochondrial membrane potential. Furthermore, Z-LEHD-FMK, a caspase-9 inhibitor, but not Z-IETD-FMK, a caspase-8 inhibitor, attenuated the overload-induced apoptosis. Our results from human samples, mouse models, and annulus fibrosus culture experiments demonstrate that the mechanical overload-induced IVD degeneration is mediated through the mitochondrial apoptotic pathway in IVD cells. PMID:14982845
Ion acoustic shock waves in degenerate plasmas
Akhtar, N.; Hussain, S.
2011-07-15
Korteweg de Vries Burgers equation for negative ion degenerate dissipative plasma has been derived using reductive perturbation technique. The quantum hydrodynamic model is used to study the quantum ion acoustic shock waves. The effects of different parameters on quantum ion acoustic shock waves are studied. It is found that quantum parameter, electrons Fermi temperature, temperature of positive and negative ions, mass ratio of positive to negative ions, viscosity, and density ratio have significant impact on the shock wave structure in negative ion degenerate plasma.
Kinematic control of robot with degenerate wrist
NASA Technical Reports Server (NTRS)
Barker, L. K.; Moore, M. C.
1984-01-01
Kinematic resolved rate equations allow an operator with visual feedback to dynamically control a robot hand. When the robot wrist is degenerate, the computed joint angle rates exceed operational limits, and unwanted hand movements can result. The generalized matrix inverse solution can also produce unwanted responses. A method is introduced to control the robot hand in the region of the degenerate robot wrist. The method uses a coordinated movement of the first and third joints of the robot wrist to locate the second wrist joint axis for movement of the robot hand in the commanded direction. The method does not entail infinite joint angle rates.
Double Degenerate Binary Systems
Yakut, K.
2011-09-21
In this study, angular momentum loss via gravitational radiation in double degenerate binary (DDB)systems (NS + NS, NS + WD, WD + WD, and AM CVn) is studied. Energy loss by gravitational waves has been estimated for each type of systems.
Biomechanics of Disc Degeneration
Palepu, V.; Kodigudla, M.; Goel, V. K.
2012-01-01
Disc degeneration and associated disorders are among the most debated topics in the orthopedic literature over the past few decades. These may be attributed to interrelated mechanical, biochemical, and environmental factors. The treatment options vary from conservative approaches to surgery, depending on the severity of degeneration and response to conservative therapies. Spinal fusion is considered to be the “gold standard” in surgical methods till date. However, the association of adjacent level degeneration has led to the evolution of motion preservation technologies like spinal arthroplasty and posterior dynamic stabilization systems. These new technologies are aimed to address pain and preserve motion while maintaining a proper load sharing among various spinal elements. This paper provides an elaborative biomechanical review of the technologies aimed to address the disc degeneration and reiterates the point that biomechanical efficacy followed by long-term clinical success will allow these nonfusion technologies as alternatives to fusion, at least in certain patient population. PMID:22745914
Degenerate astigmatic cavities
NASA Astrophysics Data System (ADS)
Courtois, Jérémie; Mohamed, Ajmal; Romanini, Daniele
2013-10-01
At the output of a high-finesse cavity a succession of Lissajous patterns may be observed as the cavity length is finely tuned inside a “degenerate region” around a reentrant spherical configuration. This behavior is ascribed to a small parasitic astigmatism of the cavity mirrors. Simple geometrical optics modeling confirms this hypothesis, and then a more realistic analysis using transverse Gaussian modes reveals that the Lissajous patterns correspond to an organization of the astigmatism-split modes into a finer substructure of degenerate modes relative to that of a reentrant spherical cavity. This provides a thorough understanding of the field patterns observed in the degenerate region, including an intriguing spatial symmetry of the patterns corresponding to opposite displacements with respect to a specific central cavity length. This investigation represents a generalization of the theory of reentrant spherical cavities to the astigmatic case.
Equilibrium configurations of degenerate fluid spheres
Whitman, P.G.
1985-04-01
Equilibrium configurations of degenerate fluid spheres which assume a polytropic form in the ultrahigh-density regime are considered. We show that analytic solutions more general than those of Misner and Zapolsky exist which possess the asymptotic equation of state. Simple expressions are derived which indicate this nature of the fluids in the extreme relativistic limit, and the stability of these interiors is considered in the asymptotic region.
Frontotemporal Lobar Degeneration
Josephs, Keith A.
2009-01-01
Synopsis Frontotemporal lobar degeneration (FTLD) is a syndromic diagnosis that encompasses at least three different variants. Imaging modalities are clinically useful in FTLD while pathology remains the gold standard for definitive diagnosis. To date three different genes have been identified that account for FTLD. PMID:17659185
Age-Related Macular Degeneration
... this page please turn Javascript on. Age-related Macular Degeneration What is AMD? Click for more information Age-related macular degeneration, ... the macula allows you to see fine detail. AMD Blurs Central Vision AMD blurs the sharp central ...
X-82 to Treat Age-related Macular Degeneration
2016-08-16
Age-Related Macular Degeneration (AMD); Macular Degeneration; Exudative Age-related Macular Degeneration; AMD; Macular Degeneration, Age-related, 10; Eye Diseases; Retinal Degeneration; Retinal Diseases
Vector polarons in a degenerate electron system
NASA Astrophysics Data System (ADS)
Clougherty, Dennis P.; Foell, Charles A.
2004-08-01
We consider a one-dimensional model of an electron in a doubly (or nearly) degenerate band that interacts with elastic distortions. We show that the electron equations of motion reduce to a set of coupled nonlinear Schrödinger equations. For the case of interband electron-phonon coupling stemming from local Jahn-Teller interactions, multicomponent self-localized polaron solutions-vector polarons- are described and classified. The phase diagram for the different types of vector polarons in this model is presented. By interpreting the components of the orbital doublet as those of spin- (1)/(2) , our results can also be used to describe bound magnetic polarons.
Differential Equations Compatible with Boundary Rational qKZ Equation
NASA Astrophysics Data System (ADS)
Takeyama, Yoshihiro
2011-10-01
We give diffierential equations compatible with the rational qKZ equation with boundary reflection. The total system contains the trigonometric degeneration of the bispectral qKZ equation of type (Cěen, Cn) which in the case of type GLn was studied by van Meer and Stokman. We construct an integral formula for solutions to our compatible system in a special case.
Frontotemporal Lobar Degeneration
Rabinovici, Gil D.; Miller, Bruce L.
2010-01-01
Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous syndrome, characterized by progressive decline in behaviour or language associated with degeneration of the frontal and anterior temporal lobes. While the seminal cases were described at the turn of the 20th century, FTLD has only recently been appreciated as a leading cause of dementia, particularly in patients presenting before the age of 65 years. Three distinct clinical variants of FTLD have been described: (i) behavioural-variant frontotemporal dementia, characterized by changes in behaviour and personality in association with frontal-predominant cortical degeneration; (ii) semantic dementia, a syndrome of progressive loss of knowledge about words and objects associated with anterior temporal neuronal loss; and (iii) progressive nonfluent aphasia, characterized by effortful language output, loss of grammar and motor speech deficits in the setting of left perisylvian cortical atrophy. The majority of pathologies associated with FTLD clinical syndromes include either tau-positive (FTLD-TAU) or TAR DNA-binding protein 43 (TDP-43)-positive (FTLD-TDP) inclusion bodies. FTLD overlaps clinically and pathologically with the atypical parkinsonian disorders corticobasal degeneration and progressive supranuclear palsy, and with amyotrophic lateral sclerosis. The majority of familial FTLD cases are caused by mutations in the genes encoding microtubule-associated protein tau (leading to FTLD-TAU) or progranulin (leading to FTLD-TDP). The clinical and pathologic heterogeneity of FTLD poses a significant diagnostic challenge, and in vivo prediction of underlying histopathology can be significantly improved by supplementing the clinical evaluation with genetic tests and emerging biological markers. Current pharmacotherapy for FTLD focuses on manipulating serotonergic or dopaminergic neurotransmitter systems to ameliorate behavioural or motor symptoms. However, recent advances in FTLD
Wang, Lei Li, Min; Qi, Feng-Hua; Xu, Tao
2015-03-15
Under investigation in this paper is a variable-coefficient derivative nonlinear Schrödinger (vc-DNLS) equation modeling the nonlinear Alfvén waves in the inhomogeneous plasmas. The modulation instability is examined for this inhomogeneous nonlinear model. The nonautonomous breather and rogue wave solutions of the vc-DNLS equation are obtained via the modified Darboux transformation. It is found that the velocity and amplitude of the breather can be controlled by the inhomogeneous magnetic field and nonuniform density. Such novel phenomena as breather amplification and nonlinear Talbot effect-like property are demonstrated with the proper choices of the inhomogeneous parameters. Furthermore, dynamics of the fundamental rogue wave, periodical rogue wave, and composite rogue wave are graphically discussed. The trajectories and amplitudes of the rogue waves can be manipulated by the inhomogeneous magnetic field and nonuniform density. In addition, the nonlinear tunneling of the rogue waves and breathers is studied. As an application, a sample model is treated with our results, and the graphical illustrations exhibit the compressing, expanding, and fluctuating phenomena of the Alfvén rogue waves.
Cortical basal ganglionic degeneration.
Scarmeas, N; Chin, S S; Marder, K
2001-10-01
In this case study, we describe the symptoms, neuropsychological testing, and brain pathology of a retired mason's assistant with cortical basal ganglionic degeneration (CBGD). CBGD is an extremely rare neurodegenerative disease that is categorized under both Parkinsonian syndromes and frontal lobe dementias. It affects men and women nearly equally, and the age of onset is usually in the sixth decade of life. CBGD is characterized by Parkinson's-like motor symptoms and by deficits of movement and cognition, indicating focal brain pathology. Neuronal cell loss is ultimately responsible for the neurological symptoms. PMID:14602941
An Unusual Case of Extensive Lattice Degeneration and Retinal Detachment
Sarma, Saurabh Kumar; Basaiawmoit, Jennifer V.
2016-01-01
Lattice degeneration of the retina is not infrequently encountered on a dilated retinal examination and many of them do not need any intervention. We report a case of atypical lattice degeneration variant with peripheral retinal detachment. An asymptomatic 35-year-old lady with minimal refractive error was found to have extensive lattice degeneration, peripheral retinal detachment and fibrotic changes peripherally with elevation of retinal vessels on dilated retinal examination. There were also areas of white without pressure, chorioretinal scarring and retinal breaks. All the changes were limited to beyond the equator but were found to span 360 degrees. She was treated with barrage laser all around to prevent extension of the retinal detachment posteriorly. She remained stable till her latest follow-up two years after the barrage laser. This case is reported for its rarity with a discussion of the probable differential diagnoses. To the best of our knowledge, this is the first report of such findings in lattice degeneration.
Relativistic Bernstein waves in a degenerate plasma
Ali, Muddasir; Hussain, Azhar; Murtaza, G.
2011-09-15
Bernstein mode for a relativistic degenerate electron plasma is investigated. Using relativistic Vlasov-Maxwell equations, a general expression for the conductivity tensor is derived and then employing Fermi-Dirac distribution function a generalized dispersion relation for the Bernstein mode is obtained. Two limiting cases, i.e., non-relativistic and ultra-relativistic are discussed. The dispersion relations obtained are also graphically presented for some specific values of the parameters depicting how the propagation characteristics of Bernstein waves as well as the Upper Hybrid oscillations are modified with the increase in plasma number density.
Macular degeneration - age-related
Age-related macular degeneration (ARMD); AMD ... distorted and wavy. There may be a small dark spot in the center of your vision that ... leafy vegetables, may also decrease your risk of age-related macular degeneration. If you have wet AMD, ...
Nonlinear isothermal waves in a degenerate electron plasma
Dubinov, A. E.; Dubinova, A. A.
2008-05-15
A nonlinear differential equation describing oscillations of the chemical potential in a one-dimensional steady-state wave propagating in a degenerate electron gas against an immobile neutralizing ion background is derived, investigated, and solved exactly. It is found that the wave phase velocity is bounded below by a critical velocity, whose exact value is obtained.
What Is Age-Related Macular Degeneration?
... Degeneration Diagnosis: How is AMD diagnosed? Macular Degeneration Treatment: How is AMD Treated? Macular ... macular degeneration (AMD) is a deterioration or breakdown of the eye's macula. The macula is a small area in the ...
Some Remarks on Space-Time Decompositions, and Degenerate Metrics, in General Relativity
NASA Astrophysics Data System (ADS)
Bengtsson, Ingemar
Space-time decomposition of the Hilbert-Palatini action, written in a form which admits degenerate metrics, is considered. Simple numerology shows why D = 3 and 4 are singled out as admitting a simple phase space. The canonical structure of the degenerate sector turns out to be awkward. However, the real degenerate metrics obtained as solutions are the same as those that occur in Ashtekar's formulation of complex general relativity. An exact solution of Ashtekar's equations, with degenerate metric, shows that the manifestly four-dimensional form of the action, and its 3 + 1 form, are not quite equivalent.
Ata-ur-Rahman,; Qamar, A.; Masood, W.; Eliasson, B.
2013-09-15
In this paper, small but finite amplitude electrostatic solitary waves in a relativistic degenerate magnetoplasma, consisting of relativistically degenerate electrons and non-degenerate cold ions, are investigated. The Zakharov-Kuznetsov equation is derived employing the reductive perturbation technique and its solitary wave solution is analyzed. It is shown that only compressive electrostatic solitary structures can propagate in such a degenerate plasma system. The effects of plasma number density, ion cyclotron frequency, and direction cosines on the profiles of ion acoustic solitary waves are investigated and discussed at length. The relevance of the present investigation vis-a-vis pulsating white dwarfs is also pointed out.
Coupled modes in magnetized dense plasma with relativistic-degenerate electrons
Khan, S. A.
2012-01-15
Low frequency electrostatic and electromagnetic waves are investigated in ultra-dense quantum magnetoplasma with relativistic-degenerate electron and non-degenerate ion fluids. The dispersion relation is derived for mobile as well as immobile ions by employing hydrodynamic equations for such plasma under the influence of electromagnetic forces and pressure gradient of relativistic-degenerate Fermi gas of electrons. The result shows the coexistence of shear Alfven and ion modes with relativistically modified dispersive properties. The relevance of results to the dense degenerate plasmas of astrophysical origin (for instance, white dwarf stars) is pointed out with brief discussion on ultra-relativistic and non-relativistic limits.
Solitons in Degenerate Electron-Phonon Systems
NASA Astrophysics Data System (ADS)
Foell, Charles; Clougherty, Dennis
2004-03-01
We consider a 1øplus 1-dimensional model describing the coupling between degenerate electron states under local Jahn-Teller interactions. In the adiabatic approximation, the equations of motion are shown to reduce to a set of coupled non-linear Schrödinger equations in the electron fields. We demonstrate that in the continuum limit solitary waves of the wave-daughter wave type are stable for sufficiently strong on-site Coulomb repulsion. Our results may have relevance to describing the electronic and optical properties of quasi-one-dimensional systems such as halogen-bridged mixed-valence transition-metal linear-chain complexes (MX chains) and polymeric fullerides.
Zakharov equations in quantum dusty plasmas
Sayed, F.; Vladimirov, S. V.; Ishihara, O.
2015-08-15
By generalizing the formalism of modulational interactions in quantum dusty plasmas, we derive the kinetic quantum Zakharov equations in dusty plasmas that describe nonlinear coupling of high frequency Langmuir waves to low frequency plasma density variations, for cases of non-degenerate and degenerate plasma electrons.
Salzmann's Nodular Degeneration.
Maharana, Prafulla K; Sharma, Namrata; Das, Sujata; Agarwal, Tushar; Sen, Seema; Prakash, Gaurav; Vajpayee, Rasik B
2016-01-01
Salzmann's nodular degeneration (SND) is a rare, noninflammatory, slowly progressive degenerative disease of the cornea that is characterized by the appearance of nodular bluish gray opacities that vary in number and size. It is usually bilateral; most commonly occurring in people aged 50-60 years old, with a female preponderance; and often associated with a history of prior corneal inflammation. The clinical features usually depend on the location of the nodules. Generally, the nodules of SND are bluish white to gray in color, 1-2 mm in size, and round, conical or prismatic in shape. The overlying Bowman's layer is usually absent from the nodular areas and is partially replaced by granular Periodic Acid Schiff-positive eosinophilic material resembling the basement membrane. Diagnostic investigations include ultrasonic pachymetry, anterior segment optical coherence tomography, ultrasound biomicroscopy, and confocal microscopy. The majority of patients respond well to conservative management with topical lubricants; severe cases may require surgical intervention. The various surgical modalities described include superficial keratectomy, which may be combined with phototherapeutic keratectomy and keratoplasty. Various modifications of these procedures include the use of alcohol-assisted epithelial delamination, intraoperative mitomycin-C or amniotic membrane transplantation to make the procedure easy, reduce the risk of recurrence and improve postoperative comfort. Recurrences are rarely reported; overall, the visual prognosis following treatment is optimal. PMID:26462409
Degenerate approach to the mean field Bose-Hubbard Hamiltonian
NASA Astrophysics Data System (ADS)
Belemuk, Alexander M.; Ryzhov, Valentin N.
2016-04-01
A degenerate variant of mean field perturbation theory for the on-site Bose-Hubbard Hamiltonian is presented. We split the perturbation into two terms and perform exact diagonalization in the two-dimensional subspace corresponding to the degenerate states. The final relations for the second order ground state energy and first order wave function do not contain singularities at integer values of the chemical potentials. The resulting equation for the phase boundary between superfluid and Mott states coincides with the prediction from the conventional mean field perturbation approach.
Nutrition and retinal degenerations.
Berson, E L
2000-01-01
Considerable progress has been made in the understanding and management of degenerative diseases of the retina involving photoreceptors. Nutritional approaches to treatment have proved successful in the case of the common forms of retinitis pigmentosa (supplementation with vitamin A), Bassen-Kornzweig disease (supplementation with vitamins A, E, and K), gyrate atrophy (low-protein, low-arginine diet and/or supplementation with vitamin B6), and Refsum disease (low-phytol, low-phytanic acid diet). The night blindness associated with Sorsby fundus dystrophy can be reversed over the short term with vitamin A. A significant trend for decreased risk for advanced or exudative ARMD has been reported among those whose diets contain a higher content of carotenoids, such as spinach and collard greens. A randomized trial is in progress to determine whether beta-carotene, vitamin C, and vitamin E as well as trace minerals, particularly zinc, will modify the course of ARMD. The difficulties that patients with retinal degenerations face as a result of their diminishing vision, sometimes over decades, cannot be underestimated. Nutritional therapy has proved effective in modifying the course of a number of these conditions; the therapeutic benefit of nutritional modification in diseases that have a genetic basis is of particular interest. Further research is warranted to determine the mechanisms by which these treatments provide their benefit as well as to identify other conditions that may yield to nutritional intervention. Risk-factor analyses of well-defined populations followed over time with food-frequency questionnaires in conjunction with careful assessments of visual function may reveal other dietary constituents that can modify the course of degenerative diseases of the retina. PMID:11064860
[Neuropsychological exploration in frontotemporal degeneration].
Peña-Casanova, J; Böhm, P
2000-01-01
The present paper discusses the neuropsychological assessment in fronto-temporal lobe degeneration. Having established the neuroanatomical and functional basis for the discussion the major syndromes included in the concept of frontotemporal degeneration are reviewed from a neuropsychological standpoint. With reference to fronto-temporal dementia the different frontal or executive function tests and their limitations are discussed. With reference to progressive aphasia and semantic dementia we differentiate the distinct language profiles as observed in aphasia batteries and general neuropsychological tests. Reference is made to especially useful tests for the differentiation of the two syndromes from each other, as well as from other primary progressive disorders. Concluding remarks postulate a series of axis of cognitive function in fronto-temporal lobe degenerations, which exist at the functional as well as the anatomical level and along which the different syndromes evolve. PMID:10723171
A nonlinear model for magnetoacoustic waves in dense dissipative plasmas with degenerate electrons
Masood, W.; Jahangir, R.; Siddiq, M.; Eliasson, B.
2014-10-15
The properties of nonlinear fast magnetoacoustic waves in dense dissipative plasmas with degenerate electrons are studied theoretically in the framework of the Zabolotskaya-Khokhlov (ZK) equation for small but finite amplitude excitations. Shock-like solutions of the ZK equation are obtained and are applied to parameters relevant to white dwarf stars.
Macular Degeneration - Multiple Languages: MedlinePlus
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Ataxias and Cerebellar or Spinocerebellar Degeneration
... Awards Enhancing Diversity Find People About NINDS NINDS Ataxias and Cerebellar or Spinocerebellar Degeneration Information Page Synonym(s): ... Publications and Information Publicaciones en Español What are Ataxias and Cerebellar or Spinocerebellar Degeneration? Ataxia often occurs ...
Emerging monochromatic fluxes and colors of red degenerate stars
NASA Technical Reports Server (NTRS)
Kapranidis, S.
1985-01-01
The emerging monochromatic fluxes and the B-V, V-I, J-H, and V-K color indices are presented for red degenerate stars with helium atmospheres which were calculated using an equation of state and opacities based on a hot Thomas-Fermi model of the helium gas. The effective temperature range is 4500-2500 K. It is found that although the emerging fluxes resemble blackbody curves, red degenerates emit more radiation than blackbodies in the short wavelength range and less in the long wavelength range. Thus, red degenerates appear bluer than blackbodies of the same temperature. The calculated colors of these models are compared to the colors of some of the coolest known non-DA degenerate stars. In particular it is found that the B-V and V-I colors of the cool white dwarf VB 11, whose temperature had been previously estimated to be higher than 4000 K, suggest a temperature of 3750 K. If this result is correct, then VB 11 is probably the coolest known white dwarf.
Nutritional supplements for macular degeneration.
2006-02-01
Age-related macular degeneration is the commonest cause of blindness in developed countries and the third most common worldwide. Each year in the UK, around 17,000 people become blind or partially sighted as a result of this condition, and its prevalence is likely to increase with an ageing population. Laser therapy and rarely surgery, can slow disease progression in a minority of patients but is unlikely to restore lost vision. A wide range of nutritional supplements are now on sale with promotional claims that they improve eye health. While some specialists recommend their use to patients with advanced disease, these supplements are also increasingly promoted to people with early or no signs of disease. Consequently, GPs come under pressure from patients to recommend, or even prescribe, a nutritional supplement. Here we examine the evidence for nutritional supplements in the management of age-related macular degeneration and consider which, if any, can be recommended. PMID:16550811
The degeneration of Y chromosomes.
Charlesworth, B; Charlesworth, D
2000-11-29
Y chromosomes are genetically degenerate, having lost most of the active genes that were present in their ancestors. The causes of this degeneration have attracted much attention from evolutionary theorists. Four major theories are reviewed here: Muller's ratchet, background selection, the Hill Robertson effect with weak selection, and the 'hitchhiking' of deleterious alleles by favourable mutations. All of these involve a reduction in effective population size as a result of selective events occurring in a non-recombining genome, and the consequent weakening of the efficacy of selection. We review the consequences of these processes for patterns of molecular evolution and variation at loci on Y chromosomes, and discuss the results of empirical studies of these patterns for some evolving Y-chromosome and neo-Y-chromosome systems. These results suggest that the effective population sizes of evolving Y or neo-Y chromosomes are severely reduced, as expected if some or all of the hypothesized processes leading to degeneration are operative. It is, however, currently unclear which of the various processes is most important; some directions for future work to help to resolve this question are discussed. PMID:11127901
Radial keratotomy associated endothelial degeneration
Moshirfar, Majid; Ollerton, Andrew; Semnani, Rodmehr T; Hsu, Maylon
2012-01-01
Purpose To describe the presentation and clinical course of eyes with a history of radial keratotomy (RK) and varying degrees of endothelial degeneration. Methods Retrospective case series were used. Results Thirteen eyes (seven patients) were identified with clinical findings of significant guttata and a prior history of RK. The mean age of presentation for cornea evaluation was 54.3 years (range: 38–72 years), averaging 18.7 years (range: 11–33 years) after RK. The presentation of guttata varied in degree from moderate to severe. Best corrected visual acuity (BCVA) ranged from 20/25 to 20/80. All patients had a history of bilateral RK, except one patient who did not develop any guttata in the eye without prior RK. No patients reported a family history of Fuch’s Dystrophy. One patient underwent a penetrating keratoplasty in one eye and a Descemet’s stripping automated endothelial keratoplasty (DSAEK) in the other eye. Conclusions RK may induce a spectrum of endothelial degeneration. In elderly patients, the findings of guttata may signify comorbid Fuch’s dystrophy in which RK incisions could potentially hasten endothelial decomposition. In these select patients with stable cornea topography and prior RK, DSAEK may successfully treat RK endothelial degeneration. PMID:22347792
Light scattering of degenerate fermions
NASA Astrophysics Data System (ADS)
Aubin, S.; Leblanc, L. J.; Myrskog, S.; Extavour, M. H. T.; McKay, D.; Stummer, A.; Thywissen, J. H.
2006-05-01
We report on progress in measuring the suppression of resonant light scattering in a gas of degenerate fermions. A gas of trapped degenerate fermions is expected to exhibit narrower optical linewidths and longer excited state lifetimes than single atoms when the Fermi energy is larger than the photon recoil energy [1-3]. In this case, the number of available states into which a scattered atom can recoil is significantly reduced due to the filling of the Fermi sea. We produce a degenerate gas of 4x10^4 ultra-cold fermionic ^40K atoms by sympathetic cooling with bosonic ^87Rb in a micro-magnetic chip trap. The atoms can then be loaded into a tight dipole trap just above the surface of the chip and probed with a near resonance laser pulse. [1] Th. Busch, J. R. Anglin, J. I. Cirac, and P. Zoller, Europhys. Lett. 44, 1 (1998). [2] B. DeMarco and D. S. Jin, Phys. Rev. A 58, R4267 (1998). [3] J. Javanainen and J. Ruostekosky, Phys. Rev. A 52, 3033 (1995). Work supported by NSERC, CFI, OIT, Research Corporation, and PRO.
General pathophysiology in retinal degeneration.
Wert, Katherine J; Lin, Jonathan H; Tsang, Stephen H
2014-01-01
Retinal degeneration, including that seen in age-related macular degeneration and retinitis pigmentosa (RP), is the most common form of neural degenerative disease in the world. There is great genetic and allelic heterogeneity of the various retinal dystrophies. Classifications of these diseases can be ambiguous, as there are similar clinical presentations in retinal degenerations arising from different genetic mechanisms. As would be expected, alterations in the activity of the phototransduction cascade, such as changes affecting the renewal and shedding of the photoreceptor OS, visual transduction, and/or retinol metabolism have a great impact on the health of the retina. Mutations within any of the molecules responsible for these visual processes cause several types of retinal and retinal pigment epithelium degenerative diseases. Apoptosis has been implicated in the rod cell loss seen in a mouse model of RP, but the precise mechanisms that connect the activation of these pathways to the loss of phosphodiesterase (PDE6β) function has yet to be defined. Additionally, the activation of apoptosis by CCAAT/-enhancer-binding protein homologous protein (CHOP), after activation of the unfolded protein response pathway, may be responsible for cell death, although the mechanism remains unknown. However, the mechanisms of cell death after loss of function of PDE6, which is a commonly studied mammalian model in research, may be generalizable to loss of function of different key proteins involved in the phototransduction cascade. PMID:24732759
General Pathophysiology in Retinal Degeneration
Wert, Katherine J.; Lin, Jonathan H.; Tsang, Stephen H.
2015-01-01
Retinal degeneration, including that seen in age-related macular degeneration and retinitis pigmentosa (RP), is the most common form of neural degenerative disease in the world. There is great genetic and allelic heterogeneity of the various retinal dystrophies. Classifications of these diseases can be ambiguous, as there are similar clinical presentations in retinal degenerations arising from different genetic mechanisms. As would be expected, alterations in the activity of the phototransduction cascade, such as changes affecting the renewal and shedding of the photoreceptor OS, visual transduction, and/ or retinol metabolism have a great impact on the health of the retina. Mutations within any of the molecules responsible for these visual processes cause several types of retinal and retinal pigment epithelium degenerative diseases. Apoptosis has been implicated in the rod cell loss seen in a mouse model of RP, but the precise mechanisms that connect the activation of these pathways to the loss of phosphodiesterase (PDE6β) function has yet to be defined. Additionally, the activation of apoptosis by CCAAT/-enhancer-binding protein homologous protein (CHOP), after activation of the unfolded protein response pathway, may be responsible for cell death, although the mechanism remains unknown. However, the mechanisms of cell death after loss of function of PDE6, which is a commonly studied mammalian model in research, may be generalizable to loss of function of different key proteins involved in the phototransduction cascade. PMID:24732759
Electrostatic rogue-waves in relativistically degenerate plasmas
Akbari-Moghanjoughi, M.
2014-10-15
In this paper, we investigate the modulational instability and the possibility of electrostatic rogue-wave propagations in a completely degenerate plasma with arbitrary degree of degeneracy, i.e., relativistically degenerate plasma, ranging from solid density to the astrophysical compact stars. The hydrodynamic approach along with the perturbation method is used to reduce the governing equations to the nonlinear Schrödinger equation from which the modulational instability, the growth rate of envelope excitations and the occurrence of rogue as well as super-rogue waves in the plasma, is evaluated. It is observed that the modulational instability in a fully degenerate plasma can be quite sensitive to the plasma number-density and the wavenumber of envelop excitations. It is further revealed that the relativistically degeneracy plasmas (R{sub 0} > 1) are almost always modulationally unstable. It is found, however, that the highly energetic sharply localized electrostatic rogue as well as super-rogue waves can exist in the astrophysical compact objects like white dwarfs and neutron star crusts. The later may provide a link to understand many physical processes in such stars and it may lead us to the origin of the random-localized intense short gamma-ray bursts, which “appear from nowhere and disappear without a trace” quite similar to oceanic rogue structures.
Energy transfer in two-wave mixing quasi-degenerated in photorefractive crystals
NASA Astrophysics Data System (ADS)
Barrera, B.; Arias Hernández, N. A.; Molina Prado, M. L.; Tebaldi, M.
2016-02-01
Wave equations describing the quasi-degenerated two-beam coupling in the photorefractive crystals for high frequency gratings have been solved. In the case of the quasi-degenerate two-beam coupling, equations depend upon the coupling coefficient, the response time of the medium, the input beams frequencies, the absorption coefficient and the input intensity ratio. The response time of the medium is function of the diffusion field, the drift field, the saturation field and the concentration ratio, i.e., the ratio between NA density of acceptor impurities and ND density of donor impurities. The effect of these parameters on the gain has been studied in details.
Shock waves and double layers in electron degenerate dense plasma with viscous ion fluids
NASA Astrophysics Data System (ADS)
Mamun, A. A.; Zobaer, M. S.
2014-02-01
The properties of ion-acoustic shock waves and double layers propagating in a viscous degenerate dense plasma (containing inertial viscous ion fluid, non-relativistic and ultra-relativistic degenerate electron fluid, and negatively charged stationary heavy element) is investigated. A new nonlinear equation (viz. Gardner equation with additional dissipative term) is derived by the reductive perturbation method. The properties of the ion-acoustic shock waves and double layers are examined by the analysis of the shock and double layer solutions of this new equation (we would like to call it "M-Z equation"). It is found that the properties of these shock and double layer structures obtained from this analysis are significantly different from those obtained from the analysis of standard Gardner or Burgers' equation. The implications of our results to dense plasmas in astrophysical objects (e.g., non-rotating white dwarf stars) are briefly discussed.
Ultraviolet spectrophotometry of degenerate stars
NASA Technical Reports Server (NTRS)
Greenstein, J. L.; Oke, J. B.
1979-01-01
Observations of one helium- and three hydrogen-atmosphere degenerates made with the International Ultraviolet Explorer are discussed. Fluxes in the UV give temperatures in good accordance with those determined from the ground and from the ANS satellite data. Profiles of the strong L-alpha absorption in two DA's fit predictions for the expected temperatures. Gravity determination is vitiated by their steep temperature dependence. If one accepts that theoretical predictions should be correct, corrections to the absolute IUE calibration derived are an upward shift of 3-5%, with irregular residuals attaining + or - 7%.
Degeneration of a Nonrecombining Chromosome
NASA Astrophysics Data System (ADS)
Rice, William R.
1994-01-01
Comparative studies suggest that sex chromosomes begin as ordinary autosomes that happen to carry a major sex determining locus. Over evolutionary time the Y chromosome is selected to stop recombining with the X chromosome, perhaps in response to accumulation of alleles beneficial to the heterogametic but harmful to the homogametic sex. Population genetic theory predicts that a nonrecombining Y chromosome should degenerate. Here this prediction is tested by application of specific selection pressures to Drosophila melanogaster populations. Results demonstrate the decay of a nonrecombining, nascent Y chromosome and the capacity for recombination to ameliorate such decay.
[Age-related macular degeneration].
Budzinskaia, M V
2014-01-01
The review provides an update on the pathogenesis and new treatment modalities for neovascular age-related macular degeneration (AMD). The impact of polymorphism in particular genes, including complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2/LOC387715), and serine peptidase (HTRA1), on AMD development is discussed. Clinical presentations of different forms of exudative AMD, that is classic, occult, or more often mixed choroidal neovascularization, retinal angiomatous proliferation, and choroidal polypoidal vasculopathy, are described. Particular attention is paid to the results of recent clinical trials and safety issues around the therapy. PMID:25715554
Mathematical glimpse on the Y chromosome degeneration
NASA Astrophysics Data System (ADS)
Lobo, M. P.
2006-04-01
The Y chromosomes are genetically degenerate and do not recombine with their matching partners X. Non-recombination of XY pairs has been pointed out as the key factor for the degeneration of the Y chromosome. The aim here is to show that there is a mathematical asymmetry in sex chromosomes which leads to the degeneration of Y chromosomes even in the absence of XX and XY recombination. A model for sex-chromosome evolution in a stationary regime is proposed. The consequences of their asymmetry are analyzed and lead us to a couple of conclusions. First, Y chromosome degeneration shows up sqrt{2} more often than X chromosome degeneration. Second, if nature prohibits female mortalities from beeing exactly 50%, then Y chromosome degeneration is inevitable.
New mouse primary retinal degeneration (rd-3)
Chang, B.; Hawes, N.L.; Roderick, T.H. ); Heckenlively, J.R. )
1993-04-01
A new mouse retinal degeneration that appears to be an excellent candidate for modeling human retinitis pigmentosa is reported. In this degeneration, called rd-3, differentiation proceeds postnatally through 2 weeks, and photoreceptor degeneration starts by 3 weeks. The rod photoreceptor loss is essentially complete by 5 weeks, whereas remnant cone cells are seen through 7 weeks. This is the only mouse homozygous retinal degeneration reported to date in which photoreceptors are initially normal. Crosses with known mouse retinal degenerations rd, Rds, nr, and pcd are negative for retinal degeneration in offspring, and linkage analysis places rd-3 on mouse chromosome 1 at 10 [+-]2.5 cM distal to Akp-1. Homology mapping suggests that the homologous human locus should be on chromosome 1q. 32 refs., 3 figs., 3 tabs.
Axon degeneration: context defines distinct pathways.
Geden, Matthew J; Deshmukh, Mohanish
2016-08-01
Axon degeneration is an essential part of development, plasticity, and injury response and has been primarily studied in mammalian models in three contexts: 1) Axotomy-induced Wallerian degeneration, 2) Apoptosis-induced axon degeneration (axon apoptosis), and 3) Axon pruning. These three contexts dictate engagement of distinct pathways for axon degeneration. Recent advances have identified the importance of SARM1, NMNATs, NAD+ depletion, and MAPK signaling in axotomy-induced Wallerian degeneration. Interestingly, apoptosis-induced axon degeneration and axon pruning have many shared mechanisms both in signaling (e.g. DLK, JNKs, GSK3α/β) and execution (e.g. Puma, Bax, caspase-9, caspase-3). However, the specific mechanisms by which caspases are activated during apoptosis versus pruning appear distinct, with apoptosis requiring Apaf-1 but not caspase-6 while pruning requires caspase-6 but not Apaf-1. PMID:27197022
Effect of trapping in a degenerate plasma in the presence of a quantizing magnetic field
Shah, H. A.; Iqbal, M. J.; Qureshi, M. N. S.; Tsintsadze, N.; Masood, W.
2012-09-15
Effect of trapping as a microscopic phenomenon in a degenerate plasma is investigated in the presence of a quantizing magnetic field. The plasma comprises degenerate electrons and non-degenerate ions. The presence of the quantizing magnetic field is discussed briefly and the effect of trapping is investigated by using the Fermi-Dirac distribution function. The linear dispersion relation for ion acoustic wave is derived in the presence of the quantizing magnetic field and its influence on the propagation characteristics of the linear ion acoustic wave is discussed. Subsequently, fully nonlinear equations for ion acoustic waves are used to obtain the Sagdeev potential and the investigation of solitary structures. The formation of solitary structures is studied both for fully and partially degenerate plasmas in the presence of a quantizing magnetic field. Both compressive and rarefactive solitons are obtained for different conditions of temperature and magnetic field.
Braces and the Yang-Baxter Equation
NASA Astrophysics Data System (ADS)
Cedó, Ferran; Jespers, Eric; Okniński, Jan
2014-04-01
Several aspects of relations between braces and non-degenerate involutive set-theoretic solutions of the Yang-Baxter equation are discussed and many consequences are derived. In particular, for each positive integer n a finite square-free multipermutation solution of the Yang-Baxter equation with multipermutation level n and an abelian involutive Yang-Baxter group is constructed. This answers a problem of Gateva-Ivanova and Cameron. It is proved that finite non-degenerate involutive set-theoretic solutions of the Yang-Baxter equation whose associated involutive Yang-Baxter group is abelian are multipermutation solutions. Earlier the authors proved this with the additional square-free hypothesis on the solutions. It is also proved that finite square-free non-degenerate involutive set-theoretic solutions associated to a left brace are multipermutation solutions.
[Age-related macular degeneration].
Garcia Layana, A
1998-01-01
Age-related macular degeneration (ARMD) is the leading cause of blindness in the occidental world. Patients suffering this process have an important reduction on their quality of life being handicapped to read, to write, to recognise faces of their friends, or even to watch the television. One of the main problems of that disease is the absence of an effective treatment able to revert the process. Laser treatment is only useful in a limited number of patients, and even in these cases recurrent lesions are frequent. These facts and the progressive ageing of our society establish the ARMD as one of the biggest aim of medical investigations for the next century, and currently is focus of attention in the most industrialised countries. One of the most promising pieces of research is focused in the investigation of the risk factors associated with the age-related macular degeneration, in order to achieve a prophylactic treatment avoiding its appearance. Diet elements such as fat ingestion or reduced antioxidant intakes are being investigated as some of these factors, what open a new possibility for a prophylactic treatment. Finally, research is looking for new therapeutic modalities such as selective radiotherapy in order to improve or maintain the vision of these patients. PMID:10420956
Bright discrete solitons in spatially modulated DNLS systems
Kevrekidis, P. G.; Horne, R. L.; Whitaker, N.; Hoq, Q. E.; Kip, D.
2015-08-04
In the present work, we revisit the highly active research area of inhomogeneously nonlinear defocusing media and consider the existence, spectral stability and nonlinear dynamics of bright solitary waves in them. We use the anti-continuum limit of vanishing coupling as the starting point of our analysis, enabling in this way a systematic characterization of the branches of solutions. Our stability findings and bifurcation characteristics reveal the enhanced robustness and wider existence intervals of solutions with a broader support, culminating in the 'extended' solution in which all sites are excited. Our eigenvalue predictions are corroborated by numerical linear stability analysis. Inmore » conclusion, the dynamics also reveal a tendency of the solution profiles to broaden, in line with the above findings. These results pave the way for further explorations of such states in discrete systems, including in higher dimensional settings.« less
Bright discrete solitons in spatially modulated DNLS systems
Kevrekidis, P. G.; Horne, R. L.; Whitaker, N.; Hoq, Q. E.; Kip, D.
2015-08-04
In the present work, we revisit the highly active research area of inhomogeneously nonlinear defocusing media and consider the existence, spectral stability and nonlinear dynamics of bright solitary waves in them. We use the anti-continuum limit of vanishing coupling as the starting point of our analysis, enabling in this way a systematic characterization of the branches of solutions. Our stability findings and bifurcation characteristics reveal the enhanced robustness and wider existence intervals of solutions with a broader support, culminating in the 'extended' solution in which all sites are excited. Our eigenvalue predictions are corroborated by numerical linear stability analysis. In conclusion, the dynamics also reveal a tendency of the solution profiles to broaden, in line with the above findings. These results pave the way for further explorations of such states in discrete systems, including in higher dimensional settings.
NASA Astrophysics Data System (ADS)
Mukta, K. N.; Zobaer, M. S.; Roy, N.; Mamun, A. A.
2015-06-01
The nonlinear propagation of dust ion-acoustic (DIA) waves in a unmagnetized collisionless degenerate dense plasma (containing degenerate electron and positron, and classical ion fluids) has been theoretically investigated. The K-dV equation has been derived by employing the reductive perturbation method and by taking into account the effect of different plasma parameters in plasma fluid. The stationary solitary wave solution of K-dV equation is obtained, and numerically analyzed to identify the basic properties of DIA solitary structures. It has been shown that depending on plasma parametric values, the degenerate plasma under consideration supports compressive or rarefactive solitary structures. It has been also found that the effect of pressures on electrons, ions, and positrons significantly modify the basic features of solitary waves that are found to exist in such a plasma system. The relevance of our results in astrophysical objects such as white dwarfs and neutron stars, which are of scientific interest, is discussed briefly.
Nonlinear ion-acoustic waves in a degenerate plasma with nuclei of heavy elements
Hossen, M. A. Mamun, A. A.
2015-10-15
The ion-acoustic (IA) solitary waves propagating in a fully relativistic degenerate dense plasma (containing relativistic degenerate electron and ion fluids, and immobile nuclei of heavy elements) have been theoretically investigated. The relativistic hydrodynamic model is used to derive the Korteweg-de Vries (K-dV) equation by the reductive perturbation method. The stationary solitary wave solution of this K-dV equation is obtained to characterize the basic features of the IA solitary structures that are found to exist in such a degenerate plasma. It is found that the effects of electron dynamics, relativistic degeneracy of the plasma fluids, stationary nuclei of heavy elements, etc., significantly modify the basic properties of the IA solitary structures. The implications of this results in astrophysical compact objects like white dwarfs are briefly discussed.
Nonlinear ion-acoustic waves in a degenerate plasma with nuclei of heavy elements
NASA Astrophysics Data System (ADS)
Hossen, M. A.; Mamun, A. A.
2015-10-01
The ion-acoustic (IA) solitary waves propagating in a fully relativistic degenerate dense plasma (containing relativistic degenerate electron and ion fluids, and immobile nuclei of heavy elements) have been theoretically investigated. The relativistic hydrodynamic model is used to derive the Korteweg-de Vries (K-dV) equation by the reductive perturbation method. The stationary solitary wave solution of this K-dV equation is obtained to characterize the basic features of the IA solitary structures that are found to exist in such a degenerate plasma. It is found that the effects of electron dynamics, relativistic degeneracy of the plasma fluids, stationary nuclei of heavy elements, etc., significantly modify the basic properties of the IA solitary structures. The implications of this results in astrophysical compact objects like white dwarfs are briefly discussed.
Imploding and exploding shocks in negative ion degenerate plasmas
Hussain, S.; Akhtar, N.
2011-08-15
Imploding and exploding shocks are studied in nonplanar geometries for negative ion degenerate plasma. Deformed Korteweg de Vries Burgers (DKdVB) equation is derived by using reductive perturbation method. Two level finite difference scheme is used for numerical analysis of DKdVB. It is observed that compressive and rarefactive shocks are observed depending on the value of quantum parameter. The effects of temperature, kinematic viscosity, mass ratio of negative to positive ions and quantum parameter on diverging and converging shocks are presented.
Exact nonlinear excitations in double-degenerate plasmas
Akbari-Moghanjoughi, M.
2012-06-15
In this work, we use the conventional hydrodynamics formalism and incorporate the Chew-Goldberger-Low double-adiabatic theory to evaluate the nonlinear electrostatic ion excitations in double-degenerate (electron spin-orbit degenerate) magnetized quantum plasmas. Based on the Sagdeev pseudopotential method, an exact general pseudopotential is calculated which leads to the allowed Mach-number range criteria for such localized density structures in an anisotropic magnetized plasma. We employ the criteria on the Mach-number range for diverse magnetized quantum plasma with different equations of state. It is remarked that various plasma fractional parameters such as the system dimensionality, ion-temperature, relativistic-degeneracy, Zeeman-energy, and plasma composition are involved in the stability of an obliquely propagating nonlinear ion-acoustic wave in a double-degenerate quantum plasma. Current study is most appropriate for nonlinear wave analysis in dense astrophysical magnetized plasma environments such as white-dwarfs and neutron-star crusts where the strong magnetic fields can be present.
Liu, Haitao; Tang, Jie; Du, Yunpeng; Saadane, Aicha; Tonade, Deoye; Samuels, Ivy; Veenstra, Alex; Palczewski, Krzysztof; Kern, Timothy S.
2016-01-01
Purpose Loss of photoreceptor cells is associated with retinal vascular degeneration in retinitis pigmentosa, whereas the presence of photoreceptor cells is implicated in vascular degeneration in diabetic retinopathy. To investigate how both the absence and presence of photoreceptors could damage the retinal vasculature, we compared two mouse models of photoreceptor degeneration (opsin−/− and RhoP23H/P23H ) and control C57Bl/5J mice, each with and without diabetes. Methods Retinal thickness, superoxide, expression of inflammatory proteins, ERG and optokinetic responses, leukocyte cytotoxicity, and capillary degeneration were evaluated at 1 to 10 months of age using published methods. Results Retinal photoreceptor cells degenerated completely in the opsin mutants by 2 to 4 months of age, and visual function subsided correspondingly. Retinal capillary degeneration was substantial while photoreceptors were still present, but slowed after the photoreceptors degenerated. Diabetes did not further exacerbate capillary degeneration in these models of photoreceptor degeneration, but did cause capillary degeneration in wild-type animals. Photoreceptor cells, however, did not degenerate in wild-type diabetic mice, presumably because the stress responses in these cells were less than in the opsin mutants. Retinal superoxide and leukocyte damage to retinal endothelium contributed to the degeneration of retinal capillaries in diabetes, and leukocyte-mediated damage was increased in both opsin mutants during photoreceptor cell degeneration. Conclusions Photoreceptor cells affect the integrity of the retinal microvasculature. Deterioration of retinal capillaries in opsin mutants was appreciable while photoreceptor cells were present and stressed, but was less after photoreceptors degenerated. This finding proves relevant to diabetes, where persistent stress in photoreceptors likewise contributes to capillary degeneration. PMID:27548901
Hot subdwarfs with degenerate companions
NASA Astrophysics Data System (ADS)
Mereghetti, Sandro
2010-10-01
Stellar evolutionary models predict that most of the hot sub-dwarfs in close binary systems have white dwarf companions. In a few cases even more massive compact objects (neutron stars or black holes) are suggested by the optical mass functions. The X-ray emission expected from accretion of the sub-dwarf's wind can reveal the nature of the compact companions and be used to derive other important information on these post-common envelope systems, as recently demonstrated by the discovery of a massive WD in HD 49798. We selected 3 promising targets from a sample of hot subdwarfs suspected to have degenerate companions. This proposal was accepted in AO9 with C priority.
Laser therapy and macular degeneration
NASA Astrophysics Data System (ADS)
Menchini, Ugo; Virgili, Gianni; Giansanti, Fabrizio; Giacomelli, Giovanni; Cappelli, Stefania
2001-10-01
Among macular diseases, choroidal neovascularization (CNV) is one of the most common causes of visual loss, especially in the form associated with age-related macular degeneration and pathologic myopia. Research on these diseases has recently evaluated new treatment modalities that use laser light differently; among these, photodynamic therapy (PDT) has been introduced in the clinical practice, allowing us to expand the possibility of reducing visual loss in patients affected by CNV. With PDT, a photosensitizer (verteporfin, VisudyneTM) is injected intravenously, and it selectively binds to new vessels; low-power laser light exposure then activates the drug, leading to oxidative damage of the endothelium and new vessels thrombosis. Yet, other therapies, such as transpupillary termotherapy, or the use of photocoagulation to cause feeder-vessel occlusion, could proof effective, but they need further investigation.
Genetics of Frontotemporal Lobar Degeneration
Galimberti, Daniela; Scarpini, Elio
2012-01-01
Frontotemporal lobar degeneration (FTLD), the most frequent neurodegenerative disorder with a presenile onset, presents with a spectrum of clinical manifestations, ranging from behavioral and executive impairment to language disorders and motor dysfunction. Familial aggregation is frequently reported, and about 10% of cases have an autosomal dominant transmission. Microtubule associated protein tau (MAPT) gene mutations have been the first ones identified and are associated with early onset behavioral variant frontotemporal dementia phenotype. More recently, progranulin gene (GRN) mutations were recognized in association with familial form of FTLD. In addition, other genes are linked to rare cases of familial FTLD. Lastly, a number of genetic risk factors for sporadic forms have also been identified. In this review, current knowledge about mutations at the basis of familial FTLD will be described, together with genetic risk factors influencing the susceptibility to FTLD. PMID:22536193
Degenerate doping of metallic anodes
Friesen, Cody A; Zeller, Robert A; Johnson, Paul B; Switzer, Elise E
2015-05-12
Embodiments of the invention relate to an electrochemical cell comprising: (i) a fuel electrode comprising a metal fuel, (ii) a positive electrode, (iii) an ionically conductive medium, and (iv) a dopant; the electrodes being operable in a discharge mode wherein the metal fuel is oxidized at the fuel electrode and the dopant increases the conductivity of the metal fuel oxidation product. In an embodiment, the oxidation product comprises an oxide of the metal fuel which is doped degenerately. In an embodiment, the positive electrode is an air electrode that absorbs gaseous oxygen, wherein during discharge mode, oxygen is reduced at the air electrode. Embodiments of the invention also relate to methods of producing an electrode comprising a metal and a doped metal oxidation product.
Degenerate adiabatic perturbation theory: Foundations and applications
NASA Astrophysics Data System (ADS)
Rigolin, Gustavo; Ortiz, Gerardo
2014-08-01
We present details and expand on the framework leading to the recently introduced degenerate adiabatic perturbation theory [Phys. Rev. Lett. 104, 170406 (2010), 10.1103/PhysRevLett.104.170406], and on the formulation of the degenerate adiabatic theorem, along with its necessary and sufficient conditions [given in Phys. Rev. A 85, 062111 (2012), 10.1103/PhysRevA.85.062111]. We start with the adiabatic approximation for degenerate Hamiltonians that paves the way to a clear and rigorous statement of the associated degenerate adiabatic theorem, where the non-Abelian geometric phase (Wilczek-Zee phase) plays a central role to its quantitative formulation. We then describe the degenerate adiabatic perturbation theory, whose zeroth-order term is the degenerate adiabatic approximation, in its full generality. The parameter in the perturbative power-series expansion of the time-dependent wave function is directly associated to the inverse of the time it takes to drive the system from its initial to its final state. With the aid of the degenerate adiabatic perturbation theory we obtain rigorous necessary and sufficient conditions for the validity of the adiabatic theorem of quantum mechanics. Finally, to illustrate the power and wide scope of the methodology, we apply the framework to a degenerate Hamiltonian, whose closed-form time-dependent wave function is derived exactly, and also to other nonexactly solvable Hamiltonians whose solutions are numerically computed.
Shock waves and double layers in electron degenerate dense plasma with viscous ion fluids
Mamun, A. A.; Zobaer, M. S.
2014-02-15
The properties of ion-acoustic shock waves and double layers propagating in a viscous degenerate dense plasma (containing inertial viscous ion fluid, non-relativistic and ultra-relativistic degenerate electron fluid, and negatively charged stationary heavy element) is investigated. A new nonlinear equation (viz. Gardner equation with additional dissipative term) is derived by the reductive perturbation method. The properties of the ion-acoustic shock waves and double layers are examined by the analysis of the shock and double layer solutions of this new equation (we would like to call it “M-Z equation”). It is found that the properties of these shock and double layer structures obtained from this analysis are significantly different from those obtained from the analysis of standard Gardner or Burgers’ equation. The implications of our results to dense plasmas in astrophysical objects (e.g., non-rotating white dwarf stars) are briefly discussed.
Liouville-Type Theorems for Steady Flows of Degenerate Power Law Fluids in the Plane
NASA Astrophysics Data System (ADS)
Bildhauer, Michael; Fuchs, Martin; Zhang, Guo
2013-09-01
We extend the Liouville-type theorems of Gilbarg and Weinberger and of Koch, Nadirashvili, Seregin and Sverák valid for the stationary variant of the classical Navier-Stokes equations in 2 D to the degenerate power law fluid model.
NASA Astrophysics Data System (ADS)
Jin-Yuan, Li; Nian-Qiao, Fang; Ji, Zhang; Yu-Long, Xue; Xue-Mu, Wang; Xiao-Bo, Yuan
2016-04-01
In the past few decades, the (1+1)-dimensional nonlinear Schrödinger (NLS) equation had been derived for envelope Rossby solitary waves in a line by employing the perturbation expansion method. But, with the development of theory, we note that the (1+1)-dimensional model cannot reflect the evolution of envelope Rossby solitary waves in a plane. In this paper, by constructing a new (2+1)-dimensional multiscale transform, we derive the (2+1)-dimensional dissipation nonlinear Schrödinger equation (DNLS) to describe envelope Rossby solitary waves under the influence of dissipation which propagate in a plane. Especially, the previous researches about envelope Rossby solitary waves were established in the zonal area and could not be applied directly to the spherical earth, while we adopt the plane polar coordinate and overcome the problem. By theoretical analyses, the conservation laws of (2+1)-dimensional envelope Rossby solitary waves as well as their variation under the influence of dissipation are studied. Finally, the one-soliton and two-soliton solutions of the (2+1)-dimensional NLS equation are obtained with the Hirota method. Based on these solutions, by virtue of the chirp concept from fiber soliton communication, the chirp effect of envelope Rossby solitary waves is discussed, and the related impact factors of the chirp effect are given. Project supported by the National Natural Science Foundation of China (Grant No. 41406018).
A Monte Carlo algorithm for degenerate plasmas
Turrell, A.E. Sherlock, M.; Rose, S.J.
2013-09-15
A procedure for performing Monte Carlo calculations of plasmas with an arbitrary level of degeneracy is outlined. It has possible applications in inertial confinement fusion and astrophysics. Degenerate particles are initialised according to the Fermi–Dirac distribution function, and scattering is via a Pauli blocked binary collision approximation. The algorithm is tested against degenerate electron–ion equilibration, and the degenerate resistivity transport coefficient from unmagnetised first order transport theory. The code is applied to the cold fuel shell and alpha particle equilibration problem of inertial confinement fusion.
Total absorption by degenerate critical coupling
Piper, Jessica R. Liu, Victor; Fan, Shanhui
2014-06-23
We consider a mirror-symmetric resonator with two ports. We show that, when excited from a single port, complete absorption can be achieved through critical coupling to degenerate resonances with opposite symmetry. Moreover, any time two resonances with opposite symmetry are degenerate in frequency and absorption is always significantly enhanced. In contrast, when two resonances with the same symmetry are nearly degenerate, there is no absorption enhancement. We numerically demonstrate these effects using a graphene monolayer on top of a photonic crystal slab, illuminated from a single side in the near-infrared.
Advances in the management of macular degeneration
2014-01-01
Current management of age-related macular degeneration (AMD) can be divided into two categories: first, anti-vasoendothelial growth factor (anti-VEGF) injection for wet macular degeneration; second, anti-oxidant vitamins for dry macular degeneration. New therapies are being developed for both of these diseases using novel technologies and different modes of administration. The hope is that some of these therapies will achieve significant improvement to current management and prevent future loss of vision in this devastating eye condition. PMID:24860651
Degenerate neuronal systems sustaining cognitive functions
Noppeney, Uta; Friston, Karl J; Price, Cathy J
2004-01-01
The remarkable resilience of cognitive functions to focal brain damage suggests that multiple degenerate neuronal systems can sustain the same function either via similar mechanisms or by implementing different cognitive strategies. In degenerate functional neuroanatomy, multiple degenerate neuronal systems might be present in a single brain where they are either co-activated or remain latent during task performance. In degeneracy over subjects, a particular function may be sustained by only one neuronal system within a subject, but by different systems over subjects. Degeneracy over subjects might have arisen from (ab)normal variation in neurodevelopmental trajectories or long-term plastic changes following structural lesions. We discuss how degenerate neuronal systems can be revealed using (1) intersubject variability, (2) multiple lesion studies and (3) an iterative approach integrating information from lesion and functional imaging studies. PMID:15610392
2016-01-01
Objective Pfirrmann disc degeneration grade is one of morphologic disc degeneration grading system and it was reliable on routine T2-weighted magnetic resonance (MR) images. The purpose of this study was to evaluate the agreement of Pfirrmann disc degeneration grade, and check the alternative technique of disc degeneration grading system. Methods Fifteen volunteers (4 medical doctors related to spinal disease, 2 medical doctors not related to spinal disease, 6 nurses in spinal hospital, and 3 para-medicines) were included in this study. Three different digitalized MR images were provided all volunteers, and they checked Pfirrmann disc degeneration grade of each disc levels after careful listening to explanation. Indeed, all volunteers checked the signal intensity of disc degeneration at the points of nucleus pulposus (NP), disc membrane, ligaments, fat, and air to modify the quantitative Pfirrmann disc degeneration grade. Results Total 225 grade results of Pfirrmann disc degeneration grade and 405 signal intensity results of quantitative Pfirrmann disc degeneration grade were analyzed. Average interobserver agreement was "moderate (mean±standard deviation, 0.575±0.251)" from poor to excellent. Completely agreed levels of Pfirrmann disc degeneration grade were only 4 levels (26.67%), and the disagreement levels were observed in 11 levels; two different grades in 8 levels (53.33%) and three different grades in 3 levels (20%). Quantitative Pfirrmann disc degeneration showed relatively cluster distribution with the interobserver deviations of 0.41-1.56 at the ratio of NP and disc membrane, and it showed relatively good cluster and distribution indicating that the proposed grading system has good discrimination ability. Conclusion Pfirrmann disc degeneration grade showed the limitation of different interobserver results, but this limitation could be overcome by using quantitative techniques of MR signal intensity. Further evaluation is needed to access its advantage
de Rham-Gabadadze-Tolley massive gravity with degenerate reference metrics
NASA Astrophysics Data System (ADS)
Cao, Li-Ming; Peng, Yuxuan; Zhang, Yun-Long
2016-06-01
In De Rham-Gabadadze-Tolley massive gravity, to get the equations of motion, the square root tensor is assumed to be invertible in the variation of the action. However, this condition cannot be fulfilled when the reference metric is degenerate. This implies that the resulting equations of motion might be different from the case where the reference metric has full rank. In this paper, by generalizing the Moore-Penrose inverse to the cases of symmetric tensors on Lorentz manifolds, we get the equations of motion of the theory with a degenerate reference metric. It is found that the equations of motion are a little bit different from those in the nondegenerate cases. Based on the result of the equations of motion, for the (2 +n )-dimensional solutions with the symmetry of n -dimensional maximally symmetric space, we prove a generalized Birkhoff-type theorem in the case where the degenerate reference metric has rank n ; i.e., we show that the solutions must be Schwarzschild type or Nariai-Bertotti-Robinson type under the given assumptions.
Frontotemporal lobar degeneration: current perspectives
Riedl, Lina; Mackenzie, Ian R; Förstl, Hans; Kurz, Alexander; Diehl-Schmid, Janine
2014-01-01
The term frontotemporal lobar degeneration (FTLD) refers to a group of progressive brain diseases, which preferentially involve the frontal and temporal lobes. Depending on the primary site of atrophy, the clinical manifestation is dominated by behavior alterations or impairment of language. The onset of symptoms usually occurs before the age of 60 years, and the mean survival from diagnosis varies between 3 and 10 years. The prevalence is estimated at 15 per 100,000 in the population aged between 45 and 65 years, which is similar to the prevalence of Alzheimer’s disease in this age group. There are two major clinical subtypes, behavioral-variant frontotemporal dementia and primary progressive aphasia. The neuropathology underlying the clinical syndromes is also heterogeneous. A common feature is the accumulation of certain neuronal proteins. Of these, the microtubule-associated protein tau (MAPT), the transactive response DNA-binding protein, and the fused in sarcoma protein are most important. Approximately 10% to 30% of FTLD shows an autosomal dominant pattern of inheritance, with mutations in the genes for MAPT, progranulin (GRN), and in the chromosome 9 open reading frame 72 (C9orf72) accounting for more than 80% of familial cases. Although significant advances have been made in recent years regarding diagnostic criteria, clinical assessment instruments, neuropsychological tests, cerebrospinal fluid biomarkers, and brain imaging techniques, the clinical diagnosis remains a challenge. To date, there is no specific pharmacological treatment for FTLD. Some evidence has been provided for serotonin reuptake inhibitors to reduce behavioral disturbances. No large-scale or high-quality studies have been conducted to determine the efficacy of non-pharmacological treatment approaches in FTLD. In view of the limited treatment options, caregiver education and support is currently the most important component of the clinical management. PMID:24600223
10. Exploring the Conformal Constraint Equations
NASA Astrophysics Data System (ADS)
Butscher, Adrian
One method of studying the asymptotic structure of spacetime is to apply Penrose's conformal rescaling technique. In this setting, the rescaled Einstein equations for the metric and the conformal factor in the unphysical spacetime degenerate where the conformal factor vanishes, namely at the boundary representing null infinity. This problem can be avoided by means of a technique of H. Friedrich, which replaces the Einstein equations in the unphysical spacetime by an equivalent system of equations which is regular at the boundary. The initial value problem for these equations produces a system of constraint equations known as the conformal constraint equations. This work describes some of the properties of the conformal constraint equations and develops a perturbative method of generating solutions near Euclidean space under certain simplifying assumptions.
Quantum spatial propagation of squeezed light in a degenerate parametric amplifier
NASA Technical Reports Server (NTRS)
Deutsch, Ivan H.; Garrison, John C.
1992-01-01
Differential equations which describe the steady state spatial evolution of nonclassical light are established using standard quantum field theoretic techniques. A Schroedinger equation for the state vector of the optical field is derived using the quantum analog of the slowly varying envelope approximation (SVEA). The steady state solutions are those that satisfy the time independent Schroedinger equation. The resulting eigenvalue problem then leads to the spatial propagation equations. For the degenerate parametric amplifier this method shows that the squeezing parameter obey nonlinear differential equations coupled by the amplifier gain and phase mismatch. The solution to these differential equations is equivalent to one obtained from the classical three wave mixing steady state solution to the parametric amplifier with a nondepleted pump.
NASA Astrophysics Data System (ADS)
Mahmood, S.; Sadiq, Safeer; Haque, Q.; Ali, Munazza Z.
2016-06-01
The obliquely propagating arbitrary amplitude electrostatic wave is studied in a dense magnetized plasma having singly and doubly charged helium ions with nonrelativistic and ultrarelativistic degenerate electrons pressures. The Fermi temperature for ultrarelativistic degenerate electrons described by N. M. Vernet [(Cambridge University Press, Cambridge, 2007), p. 57] is used to define ion acoustic speed in ultra-dense plasmas. The pseudo-potential approach is used to solve the fully nonlinear set of dynamic equations for obliquely propagating electrostatic waves in a dense magnetized plasma containing helium ions. The upper and lower Mach number ranges for the existence of electrostatic solitons are found which depends on the obliqueness of the wave propagation with respect to applied magnetic field and charge number of the helium ions. It is found that only compressive (hump) soliton structures are formed in all the cases and only subsonic solitons are formed for a singly charged helium ions plasma case with nonrelativistic degenerate electrons. Both subsonic and supersonic soliton hump structures are formed for doubly charged helium ions with nonrelativistic degenerate electrons and ultrarelativistic degenerate electrons plasma case containing singly as well as doubly charged helium ions. The effect of propagation direction on the soliton amplitude and width of the electrostatic waves is also presented. The numerical plots are also shown for illustration using dense plasma parameters of a compact star (white dwarf) from literature.
Prospectives for Gene Therapy of Retinal Degenerations
Thumann, Gabriele
2012-01-01
Retinal degenerations encompass a large number of diseases in which the retina and associated retinal pigment epithelial (RPE) cells progressively degenerate leading to severe visual disorders or blindness. Retinal degenerations can be divided into two groups, a group in which the defect has been linked to a specific gene and a second group that has a complex etiology that includes environmental and genetic influences. The first group encompasses a number of relatively rare diseases with the most prevalent being Retinitis pigmentosa that affects approximately 1 million individuals worldwide. Attempts have been made to correct the defective gene by transfecting the appropriate cells with the wild-type gene and while these attempts have been successful in animal models, human gene therapy for these inherited retinal degenerations has only begun recently and the results are promising. To the second group belong glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). These retinal degenerations have a genetic component since they occur more often in families with affected probands but they are also linked to environmental factors, specifically elevated intraocular pressure, age and high blood sugar levels respectively. The economic and medical impact of these three diseases can be assessed by the number of individuals affected; AMD affects over 30 million, DR over 40 million and glaucoma over 65 million individuals worldwide. The basic defect in these diseases appears to be the relative lack of a neurogenic environment; the neovascularization that often accompanies these diseases has suggested that a decrease in pigment epithelium-derived factor (PEDF), at least in part, may be responsible for the neurodegeneration since PEDF is not only an effective neurogenic and neuroprotective agent but also a potent inhibitor of neovascularization. In the last few years inhibitors of vascularization, especially antibodies against vascular endothelial cell
Antioxidative nanofullerol prevents intervertebral disk degeneration
Yang, Xinlin; Jin, Li; Yao, Lu; Shen, Francis H; Shimer, Adam L; Li, Xudong
2014-01-01
Compelling evidence suggests that reactive oxygen species (ROS) play a pivotal role in disk degeneration. Fullerol nanoparticles prepared in aqueous solution have been demonstrated to have outstanding ability to scavenge ROS. In this report, in vitro and in vivo models were used to study the efficacy of fullerol in preventing disk degeneration. For in vitro experiments, a pro-oxidant H2O2 or an inflammatory cytokine interleukin (IL)-1β was employed to induce degenerated phenotypes in human nucleus pulposus cells encapsulated in alginate beads, and fullerol was added in the culture medium. For the animal study, an annulus-puncture model with rabbit was created, and fullerol was injected into disks. It was shown that cytotoxicity and cellular ROS level induced by H2O2 were significantly diminished by fullerol. IL-1β-induced nitric oxide generation in culture medium was suppressed by fullerol as well. Gene-profile and biochemical assays showed that fullerol effectively reversed the matrix degradation caused by either H2O2 or IL-1β. The animal study delineated that intradiskal injection of fullerol prevented disk degeneration, increasing water and proteoglycan content and inhibiting ectopic bone formation. These results suggest that antioxidative fullerol may have a potential therapeutic application for disk degeneration. PMID:24876775
Optic pathway degeneration in Japanese black cattle
CHIBA, Shiori; FUNATO, Shingo; HORIUCHI, Noriyuki; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu
2014-01-01
Degeneration of the optic pathway has been reported in various animal species including cattle. We experienced a case of bilateral optic tract degeneration characterized by severe gliosis in a Japanese black cattle without any obvious visual defects. To evaluate the significance, pathological nature and pathogenesis of the lesions, we examined the optic pathway in 60 cattle (41 Japanese black, 13 Holstein and 6 crossbreed) with or without ocular abnormalities. None of these animals had optic canal stenosis. Degenerative changes with severe gliosis in the optic pathway, which includes the optic nerve, optic chiasm and optic tract, were only observed in 8 Japanese black cattle with or without ocular abnormalities. Furthermore, strong immunoreactivity of glial fibrillary acidic protein was observed in the retinal stratum opticum and ganglion cell layer in all 5 cattle in which the optic pathway lesions could be examined. As etiological research, we also examined whether the concentrations of vitamin A and vitamin B12 or bovine viral diarrhea virus (BVDV) infection was associated with optic pathway degeneration. However, our results suggested that the observed optic pathway degeneration was probably not caused by these factors. These facts indicate the presence of optic pathway degeneration characterized by severe gliosis that has never been reported in cattle without bilateral compressive lesions in the optic pathway or bilateral severe retinal atrophy. PMID:25421501
Perpendicular propagating modes for weakly magnetized relativistic degenerate plasma
Abbas, Gohar; Bashir, M. F.; Murtaza, G.
2012-07-15
Using the Vlasov-Maxwell system of equations, the dispersion relations for the perpendicular propagating modes (i.e., X-mode, O-mode, and upper hybrid mode) are derived for a weakly magnetized relativistic degenerate electron plasma. By using the density (n{sub 0}=p{sub F}{sup 3}/3{pi}{sup 2} Planck-Constant-Over-Two-Pi {sup 3}) and the magnetic field values for different relativistic degenerate environments, the propagation characteristics (i.e., cutoff points, resonances, dispersions, and band widths in k-space) of these modes are examined. It is observed that the relativistic effects suppress the effect of ambient magnetic field and therefore the cutoff and resonance points shift towards the lower frequency regime resulting in enhancement of the propagation domain. The dispersion relations of these modes for the non-relativistic limit (p{sub F}{sup 2} Much-Less-Than m{sub 0}{sup 2}c{sup 2}) and the ultra-relativistic limit (p{sub F}{sup 2} Much-Greater-Than m{sub 0}{sup 2}c{sup 2}) are also presented.
Dwarf spheroidal galaxies as degenerate gas of free fermions
Domcke, Valerie; Urbano, Alfredo E-mail: alfredo.urbano@sissa.it
2015-01-01
In this paper we analyze a simple scenario in which Dark Matter (DM) consists of free fermions with mass m{sub f}. We assume that on galactic scales these fermions are capable of forming a degenerate Fermi gas, in which stability against gravitational collapse is ensured by the Pauli exclusion principle. The mass density of the resulting con figuration is governed by a non-relativistic Lane-Emden equation, thus leading to a universal cored profile that depends only on one free parameter in addition to m{sub f}. After reviewing the basic formalism, we test this scenario against experimental data describing the velocity dispersion of the eight classical dwarf spheroidal galaxies of the Milky Way. We find that, despite its extreme simplicity, the model exhibits a good fit to the data and realistic predictions for the size of DM halos providing that m{sub f}≅ 200 eV. Furthermore, we show that in this setup larger galaxies correspond to the non-degenerate limit of the gas. We propose a concrete realization of this model in which DM is produced non-thermally via inflaton decay. We show that imposing the correct relic abundance and the bound on the free-streaming length constrains the inflation model in terms of inflaton mass, its branching ratio into DM and the reheating temperature.
Dwarf spheroidal galaxies as degenerate gas of free fermions
NASA Astrophysics Data System (ADS)
Domcke, Valerie; Urbano, Alfredo
2015-01-01
In this paper we analyze a simple scenario in which Dark Matter (DM) consists of free fermions with mass mf. We assume that on galactic scales these fermions are capable of forming a degenerate Fermi gas, in which stability against gravitational collapse is ensured by the Pauli exclusion principle. The mass density of the resulting con figuration is governed by a non-relativistic Lane-Emden equation, thus leading to a universal cored profile that depends only on one free parameter in addition to mf. After reviewing the basic formalism, we test this scenario against experimental data describing the velocity dispersion of the eight classical dwarf spheroidal galaxies of the Milky Way. We find that, despite its extreme simplicity, the model exhibits a good fit to the data and realistic predictions for the size of DM halos providing that mfsimeq 200 eV. Furthermore, we show that in this setup larger galaxies correspond to the non-degenerate limit of the gas. We propose a concrete realization of this model in which DM is produced non-thermally via inflaton decay. We show that imposing the correct relic abundance and the bound on the free-streaming length constrains the inflation model in terms of inflaton mass, its branching ratio into DM and the reheating temperature.
The cell stress machinery and retinal degeneration.
Athanasiou, Dimitra; Aguilà, Monica; Bevilacqua, Dalila; Novoselov, Sergey S; Parfitt, David A; Cheetham, Michael E
2013-06-27
Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeostasis in all the different retinal cell types is crucial for healthy vision. The retina can be exposed to a variety of environmental insults and stress, including light-induced damage, oxidative stress and inherited mutations that can lead to protein misfolding. Within retinal cells there are different mechanisms to cope with disturbances in proteostasis, such as the heat shock response, the unfolded protein response and autophagy. In this review, we discuss the multiple responses of the retina to different types of stress involved in retinal degenerations, such as retinitis pigmentosa, age-related macular degeneration and glaucoma. Understanding the mechanisms that maintain and re-establish proteostasis in the retina is important for developing new therapeutic approaches to fight blindness. PMID:23684651
Potential Outcome Factors in Subacute Combined Degeneration
Vasconcelos, Olavo M; Poehm, Erika H; McCarter, Robert J; Campbell, William W; Quezado, Zenaide M N
2006-01-01
BACKGROUND Subacute combined degeneration is an acquired myelopathy caused by vitamin B12 deficiency. Therapy with B12 leads to improvement in most but to complete recovery in only a few patients. Prognostic indicators in subacute combined degeneration are unknown; therefore, predicting complete recovery of neurologic deficits is challenging. PURPOSE To identify potential correlates of outcome and to generate hypotheses concerning predictors of complete resolution of neurologic deficits in subacute combined degeneration. DATA SOURCE We searched EMBASE (1974 to October 2005), MEDLINE (1968 to October 2005), and references from identified reports. REPORTS SELECTION Reports of patients with subacute combined degeneration containing results of magnetic resonance imaging (MRI) and description of outcome and 1 patient treated by the authors. DATA EXTRACTION, SYNTHESIS We extracted data from 45 reports and 57 patients (36 males, 21 females; age range: 10 to 81) with a diagnosis of subacute combined degeneration, and estimated the strength of association between clinical, laboratory, and radiological factors and complete resolution of signs and symptoms. RESULTS Eight patients (14%) achieved clinical resolution and 49 (86%) improved with B12 therapy. The absence of sensory dermatomal deficit, Romberg, and Babinski signs were associated with a higher complete resolution rate. Patients with MRI lesions in ≤7 segments and age less than 50 also appear to have higher rates of complete resolution. CONCLUSIONS B12 therapy is reported to stop progression and improve neurologic deficits in most patients with subacute combined degeneration. However, complete resolution only occurs in a small percentage of patients and appears to be associated with factors suggestive of less severe disease at the time of diagnosis. PMID:16970556
Magnetohydrodynamic spin waves in degenerate electron-positron-ion plasmas
Mushtaq, A.; Maroof, R.; Ahmad, Zulfiaqr; Qamar, A.
2012-05-15
Low frequency magnetosonic waves are studied in magnetized degenerate electron-positron-ion plasmas with spin effects. Using the fluid equations of magnetoplasma with quantum corrections due to the Bohm potential, temperature degeneracy, and spin magnetization energy, a generalized dispersion relation for oblique magnetosonic waves is derived. Spin effects are incorporated via spin force and macroscopic spin magnetization current. For three different values of angle {theta}, the generalized dispersion relation is reduced to three different relations under the low frequency magnetohydrodynamic assumptions. It is found that the effect of quantum corrections in the presence of positron concentration significantly modifies the dispersive properties of these modes. The importance of the work relevant to compact astrophysical bodies is pointed out.
Nonlinear positron-acoustic waves in fully relativistic degenerate plasmas
NASA Astrophysics Data System (ADS)
Hossen, M. A.; Mamun, A. A.
2016-03-01
The nonlinear positron-acoustic (PA) waves propagating in a fully relativistic electron-positron-ion (EPI) plasma (containing degenerate electrons and positrons, and immobile heavy ions) have been theoretically investigated. A fully relativistic hydrodynamic model, which is consistent with the relativistic principle has been used, and the reductive perturbation method is employed to derive the dynamical Korteweg-de Vries equation. The dynamics of electrons as well as positrons, and the presence of immobile heavy ions are taken into account. It is found that the effects of relativistic degeneracy of electrons and positrons, static heavy ions, plasma particles velocity, enthalpy, etc have significantly modified the basic properties of the PA solitary waves propagating in the fully relativistic EPI plasmas. The application of the results of our present work in astrophysical compact objects such as white dwarfs and neutron stars, etc are briefly discussed.
Nonlocal Equations with Measure Data
NASA Astrophysics Data System (ADS)
Kuusi, Tuomo; Mingione, Giuseppe; Sire, Yannick
2015-08-01
We develop an existence, regularity and potential theory for nonlinear integrodifferential equations involving measure data. The nonlocal elliptic operators considered are possibly degenerate and cover the case of the fractional p-Laplacean operator with measurable coefficients. We introduce a natural function class where we solve the Dirichlet problem, and prove basic and optimal nonlinear Wolff potential estimates for solutions. These are the exact analogs of the results valid in the case of local quasilinear degenerate equations established by Boccardo and Gallouët (J Funct Anal 87:149-169, 1989, Partial Differ Equ 17:641-655, 1992) and Kilpeläinen and Malý (Ann Scuola Norm Sup Pisa Cl Sci (IV) 19:591-613, 1992, Acta Math 172:137-161, 1994). As a consequence, we establish a number of results that can be considered as basic building blocks for a nonlocal, nonlinear potential theory: fine properties of solutions, Calderón-Zygmund estimates, continuity and boundedness criteria are established via Wolff potentials. A main tool is the introduction of a global excess functional that allows us to prove a nonlocal analog of the classical theory due to Campanato (Ann Mat Pura Appl (IV) 69:321-381, 1965). Our results cover the case of linear nonlocal equations with measurable coefficients, and the one of the fractional Laplacean, and are new already in such cases.
Pathogenesis of tendinopathies: inflammation or degeneration?
Abate, Michele; Gravare-Silbernagel, Karin; Siljeholm, Carl; Di Iorio, Angelo; De Amicis, Daniele; Salini, Vincenzo; Werner, Suzanne; Paganelli, Roberto
2009-01-01
The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies. PMID:19591655
Retinal Cell Degeneration in Animal Models
Niwa, Masayuki; Aoki, Hitomi; Hirata, Akihiro; Tomita, Hiroyuki; Green, Paul G.; Hara, Akira
2016-01-01
The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl2-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage. PMID:26784179
CT of sarcomatous degeneration in neurofibromatosis
Coleman, B.G.; Arger, P.H.; Dalinka, M.K.; Obringer, A.C.; Raney, B.R.; Meadows, A.T.
1983-02-01
Neurofibromatosis is a relatively common disorder that often involves many organ systems. One of the least understood aspects of this malady is a well documented potential for sarcomatous degeneration of neurofibromas. The inability to identify patients at risk and the lack of noninvasive screening methods for symptomatic patients often leads to late diagnosis. In six of seven subsequently proven neurofibrosarcomas, CT demonstrated low-density areas that histopathologically appeared to be due to necrosis, hemorrhage, and/or cystic degeneration. The density differences within these sarcomas were enhanced by the intravenous adminstration of iodinated contrast agents.
Degenerate mobilities in phase field models are insufficient to capture surface diffusion
NASA Astrophysics Data System (ADS)
Lee, Alpha A.; Münch, Andreas; Süli, Endre
2015-08-01
Phase field models frequently provide insight into phase transitions and are robust numerical tools to solve free boundary problems corresponding to the motion of interfaces. A body of prior literature suggests that interface motion via surface diffusion is the long-time, sharp interface limit of microscopic phase field models such as the Cahn-Hilliard equation with a degenerate mobility function. Contrary to this conventional wisdom, we show that the long-time behaviour of degenerate Cahn-Hilliard equation with a polynomial free energy undergoes coarsening, reflecting the presence of bulk diffusion, rather than pure surface diffusion. This reveals an important limitation of phase field models that are frequently used to model surface diffusion.
Nonlinear structure of ion-acoustic waves in completely degenerate electron-positron and ion plasma
Rasheed, A.; Tsintsadze, N. L.; Murtaza, G.
2010-07-15
A rigorous theoretical investigation has been made of fully nonlinear ion-acoustic waves in nonrelativistic and ultrarelativistic, collisionless, unmagnetized plasma containing of degenerate electrons and positrons, and classical cold ions. In both (nonrelativistic and ultrarelativistic) regimes the electrons and positrons are assumed to follow the corresponding Fermi distribution while the ions are described by the hydrodynamic equations. An energy balancelike equation involving a Sagdeev-type pseudopotential is derived separately for both the regimes. In addition, stationary periodic and solitary waves are also investigated for the two cases. The present work would be helpful to understand the excitation of nonlinear ion-acoustic waves in a degenerate plasma such as in superdense white dwarfs.
Driving and Age-Related Macular Degeneration
Owsley, Cynthia; McGwin, Gerald
2009-01-01
This article reviews the research literature on driving and age-related macular degeneration, which is motivated by the link between driving and the quality of life of older adults and their increased collision rate. It addresses the risk of crashes, driving performance, driving difficulty, self-regulation, and interventions to enhance, safety, and considers directions for future research. PMID:20046818
A family of degenerate Lie algebras
NASA Astrophysics Data System (ADS)
Cruz, I.
1999-08-01
We show that almost all the real Lie algebras with only zero- and two-dimensional coadjoint orbits are degenerate in both the smooth and analytic category. The only exceptions are the already known cases (studied for example by Dufour and Weinstein).
Driving and Age-Related Macular Degeneration
ERIC Educational Resources Information Center
Owsley, Cynthia; McGwin, Gerald, Jr.
2008-01-01
This article reviews the research literature on driving and age-related macular degeneration, which is motivated by the link between driving and the quality of life of older adults and their increased collision rate. It addresses the risk of crashes, driving performance, driving difficulty, self-regulation, and interventions to enhance, safety,…
Depression in Age-Related Macular Degeneration
ERIC Educational Resources Information Center
Casten, Robin; Rovner, Barry
2008-01-01
Age-related macular degeneration (AMD) is a major cause of disability in the elderly, substantially degrades the quality of their lives, and is a risk factor for depression. Rates of depression in AMD are substantially greater than those found in the general population of older people, and are on par with those of other chronic and disabling…
Spectroscopic observations of cool degenerate star candidates
NASA Technical Reports Server (NTRS)
Hintzen, P.
1986-01-01
Spectroscopic observations are reported for 23 Luyten Half-Second degenerate star candidates and for 13 Luyten-Palomar common proper-motion pairs containing possible degenerate star components. Twenty-five degenerate stars are identified, 20 of which lack previous spectroscopy. Most of these stars are cool - Luyten color class g or later. One star, LP 77-57, shows broad continuum depressions similar to those in LHS 1126, which Liebert and Dahn attributed to pressure-shifted C2. A second degenerate star, LHS 290, exhibits apparent strong Swan bands which are blueshifted about 75 A. Further observations, including polarimetry and photometry, are required to appraise the spectroscopic peculiarities of these stars. Finally, five cool, sharp-lined DA white dwarfs have been observed to detect lines of metals and to determine line strengths. None of these DAs show signs of Mg b or the G band, and four show no evidence of Ca II K. The attempt to detect Ca MI in the fifth star, G199-71, was inconclusive.
Tenascin-C and human tendon degeneration.
Riley, G. P.; Harrall, R. L.; Cawston, T. E.; Hazleman, B. L.; Mackie, E. J.
1996-01-01
We investigated the distribution of tenascin in supraspinatus tendons to determine whether an alteration in tenascin expression was associated with human tendon degeneration. Tenascin was present in all of the tendons studied, although with two distinct patterns of expression. First, tenascin was associated with organized, fibrous regions of the tendon matrix that were typical of the normal tendon structure. This distribution is consistent with a role for tenascin in collagen fibril organization, perhaps maintaining the interface between fibrils and adjacent structures. Second, although tenascin was generally absent from poorly organized matrix in degenerate tendons, it was strongly associated with some rounded cells in disorganized fibrocartilaginous regions that were more abundant in pathological specimens. Tenascin was also found around infiltrating blood vessels, with more intense staining associated with a mononuclear cell infiltrate. Western blotting of tendon extracts showed differences in tenascin isoform expression, with only the small (200-kd) tenascin isoform found in normal tendons. Degenerate tendons also expressed the 300-kd isoform, consistent with a role for the larger tenascin isoform in tendon disease, potentially stimulating tenocyte proliferation, cell rounding, and fibrocartilaginous change. Proteolytic fragments of tenascin were detected but only in ruptured tendons, an indication of matrix remodeling in degenerate tendons, with fragment sizes consistent with the activity of matrix metalloproteinase enzymes. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:8780397
Quantum degeneracy corrections to plasma line emission and to Saha equation
NASA Astrophysics Data System (ADS)
Molinari, V. G.; Mostacci, D.; Rocchi, F.; Sumini, M.
2003-09-01
The effect of quantum degeneracy on the electron collisional excitation is investigated, and its effects on line emission evaluated for applications to spectroscopy of dense, cold plasmas. A correction to Saha equation for weakly-degenerate plasmas is also presented.
NASA Astrophysics Data System (ADS)
Li, Jiang-Fan; Fang, Jia-Yuan; Xiao, Fu-Liang; Liu, Xin-Hai; Wang, Cheng-Zhi
2009-03-01
By properly selecting the time-dependent unitary transformation for the linear combination of the number operators, we construct a time-dependent invariant and derive the corresponding auxiliary equations for the degenerate and non-degenerate coupled parametric down-conversion system with driving term. By means of this invariant and the Lewis-Riesenfeld quantum invariant theory, we obtain closed formulae of the quantum state and the evolution operator of the system. We show that the time evolution of the quantum system directly leads to production of various generalized one- and two-mode combination squeezed states, and the squeezed effect is independent of the driving term of the Hamiltonian. In some special cases, the current solution can reduce to the results of the previous works.
Purinergic signaling in retinal degeneration and regeneration.
Reichenbach, Andreas; Bringmann, Andreas
2016-05-01
Purinergic signaling is centrally involved in mediating the degeneration of the injured and diseased retina, the induction of retinal gliosis, and the protection of the retinal tissue from degeneration. Dysregulated calcium signaling triggered by overactivation of P2X7 receptors is a crucial step in the induction of neuronal and microvascular cell death under pathogenic conditions like ischemia-hypoxia, elevated intraocular pressure, and diabetes, respectively. Overactivation of P2X7 plays also a pathogenic role in inherited and age-related photoreceptor cell death and in the age-related dysfunction and degeneration of the retinal pigment epithelium. Gliosis of micro- and macroglial cells, which is induced and/or modulated by purinergic signaling and associated with an impaired homeostatic support to neurons, and the ATP-mediated propagation of retinal gliosis from a focal injury into the surrounding noninjured tissue are involved in inducing secondary cell death in the retina. On the other hand, alterations in the glial metabolism of extracellular nucleotides, resulting in a decreased level of ATP and an increased level of adenosine, may be neuroprotective in the diseased retina. Purinergic signals stimulate the proliferation of retinal glial cells which contributes to glial scarring which has protective effects on retinal degeneration and adverse effects on retinal regeneration. Pharmacological modulation of purinergic receptors, e.g., inhibition of P2X and activation of adenosine receptors, may have clinical importance for the prevention of photoreceptor, neuronal, and microvascular cell death in diabetic retinopathy, retinitis pigmentosa, age-related macular degeneration, and glaucoma, respectively, for the clearance of retinal edema, and the inhibition of dysregulated cell proliferation in proliferative retinopathies. This article is part of a Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'. PMID:25998275
Chai, Jee Won; Lee, Joon Woo; Kim, Su-Jin; Hong, Sung Hwan
2016-01-01
Objective To evaluate T2 relaxation time change using axial T2 mapping in a rabbit degenerated disc model and determine the most correlated variable with histologic score among T2 relaxation time, disc height index, and Pfirrmann grade. Materials and Methods Degenerated disc model was made in 4 lumbar discs of 11 rabbits (n = 44) by percutaneous annular puncture with various severities of an injury. Lumbar spine lateral radiograph, MR T2 sagittal scan and MR axial T2 mapping were obtained at baseline and 2 weeks and 4 weeks after the injury in 7 rabbits and at baseline and 2 weeks, 4 weeks, and 6 weeks after the injury in 4 rabbits. Generalized estimating equations were used for a longitudinal analysis of changes in T2 relaxation time in degenerated disc model. T2 relaxation time, disc height index and Pfirrmann grade were correlated with the histologic scoring of disc degeneration using Spearman's rho test. Results There was a significant difference in T2 relaxation time between uninjured and injured discs after annular puncture. Progressive decrease in T2 relaxation time was observed in injured discs throughout the study period. Lower T2 relaxation time was observed in the more severely injured discs. T2 relaxation time showed the strongest inverse correlation with the histologic score among the variables investigated (r = -0.811, p < 0.001). Conclusion T2 relaxation time measured with axial T2 mapping in degenerated discs is a potential method to assess disc degeneration. PMID:26798222
ERIC Educational Resources Information Center
Nibbelink, William H.
1990-01-01
Proposed is a gradual transition from arithmetic to the idea of an equation with variables in the elementary grades. Vertical and horizontal formats of open sentences, the instructional sequence, vocabulary, and levels of understanding are discussed in this article. (KR)
Strongly asymmetric discrete Painlevé equations: The multiplicative case
NASA Astrophysics Data System (ADS)
Grammaticos, B.; Ramani, A.; Tamizhmani, K. M.; Tamizhmani, T.; Satsuma, J.
2016-04-01
We examine a class of multiplicative discrete Painlevé equations which may possess a strongly asymmetric form. When the latter occurs, the equation is written as a system of two equations the right hand sides of which have different functional forms. The present investigation focuses upon two canonical families of the Quispel-Roberts-Thompson classification which contain equations associated with the affine Weyl groups D5 ( 1 ) and E6 ( 1 ) (or groups appearing lower in the degeneration cascade of these two). Many new discrete Painlevé equations with strongly asymmetric forms are obtained.
Mahmood, S.; Sadiq, Safeer; Haque, Q.
2013-12-15
Linear and nonlinear electrostatic waves in magnetized dense electron-ion plasmas are studied with nonrelativistic and ultra-relativistic degenerate and singly, doubly charged helium (He{sup +}, He{sup ++}) and hydrogen (H{sup +}) ions, respectively. The dispersion relation of electrostatic waves in magnetized dense plasmas is obtained under both the energy limits of degenerate electrons. Using reductive perturbation method, the Zakharov-Kuznetsov equation for nonlinear propagation of electrostatic solitons in magnetized dense plasmas is derived for both nonrelativistic and ultra-relativistic degenerate electrons. It is found that variations in plasma density, magnetic field intensity, different mass, and charge number of ions play significant role in the formation of electrostatic solitons in magnetized dense plasmas. The numerical plots are also presented for illustration using the parameters of dense astrophysical plasma situations such as white dwarfs and neutron stars exist in the literature. The present investigation is important for understanding the electrostatic waves propagation in the outer periphery of compact stars which mostly consists of hydrogen and helium ions with degenerate electrons in dense magnetized plasmas.
Nonlinear electromagnetic perturbations in a degenerate ultrarelativistic electron-positron plasma.
El-Taibany, W F; Mamun, A A
2012-02-01
Nonlinear propagation of fast and slow magnetosonic perturbation modes in an ultrarelativistic, ultracold, degenerate (extremely dense) electron positron (EP) plasma (containing ultrarelativistic, ultracold, degenerate electron and positron fluids) has been investigated by the reductive perturbation method. The Alfvén wave velocity is modified due to the presence of the enthalpy correction in the fluid equations of motion. The degenerate EP plasma system (under consideration) supports the Korteweg-de Vries (KdV) solitons, which are associated with either fast or slow magnetosonic perturbation modes. It is found that the ultrarelativistic model leads to compressive (rarefactive) electromagnetic solitons corresponding to the fast (slow) wave mode. There are certain critical angles, θ(c), at which no soliton solution is found corresponding to the fast wave mode. For the slow mode, the magnetic-field intensity affects both the soliton amplitude and width. It is also illustrated that the basic features of the electromagnetic solitary structures, which are found to exist in such a degenerate EP plasma, are significantly modified by the effects of enthalpy correction, electron and positron degeneracy, magnetic-field strength, and the relativistic effect. The applications of the results in a pair-plasma medium, which occurs in many astrophysical objects (e.g., pulsars, white dwarfs, and neutron stars) are briefly discussed. PMID:22463336
NEUTRINO PROCESSES IN PARTIALLY DEGENERATE NEUTRON MATTER
Bacca, S.; Hally, K.; Liebendoerfer, M.; Perego, A.; Pethick, C. J.; Schwenk, A.
2012-10-10
We investigate neutrino processes for conditions reached in simulations of core-collapse supernovae. In regions where neutrino-matter interactions play an important role, matter is partially degenerate, and we extend earlier work that addressed the degenerate regime. We derive expressions for the spin structure factor in neutron matter, which is a key quantity required for evaluating rates of neutrino processes. We show that, for essentially all conditions encountered in the post-bounce phase of core-collapse supernovae, it is a very good approximation to calculate the spin relaxation rates in the nondegenerate limit. We calculate spin relaxation rates based on chiral effective field theory interactions and find that they are typically a factor of two smaller than those obtained using the standard one-pion-exchange interaction alone.
Inflammation in intervertebral disc degeneration and regeneration
Molinos, Maria; Almeida, Catarina R.; Caldeira, Joana; Cunha, Carla; Gonçalves, Raquel M.; Barbosa, Mário A.
2015-01-01
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players. PMID:25673296
Shell nuclear explosions in degenerate dwarfs
NASA Astrophysics Data System (ADS)
Kuznetsov, O. A.; Tutukov, A. V.; Chechetkin, V. M.
1989-08-01
Numerical gas dynamics simulations are used to study shell nuclear explosions of degenerate carbon-oxygen dwarfs with masses of 1.17, 1.36, and 1.42 solar masses. It is assumed that the calorific capacity of the burning shell matter is between 5 X 10 to the 17th and 5 X 10 to the 18th erg/g. It is shown that, at a low calorific capacity, a remnant may form if the mass of the shell is less than 90 percent of the mass of the degenerate dwarf. In the case of high calorific capacity, a remnant may form only if the mass of the shell is less than half of the dwarf's mass.
Degeneration and regeneration of ganglion cell axons.
Weise, J; Ankerhold, R; Bähr, M
2000-01-15
The retino-tectal system has been used to study developmental aspects of axon growth, synapse formation and the establishment of a precise topographic order as well as degeneration and regeneration of adult retinal ganglion cell (RGC) axons after axonal lesion. This paper reviews some novel findings that provide new insights into the mechanisms of developmental RGC axon growth, pathfinding, and target formation. It also focuses on the cellular and molecular cascades that underlie RGC degeneration following an axonal lesion and on some therapeutic strategies to enhance survival of axotomized RGCs in vivo. In addition, this review deals with problems related to the induction of regeneration after axonal lesion in the adult CNS using the retino-tectal system as model. Different therapeutic approaches to promote RGC regeneration and requirements for specific target formation of regenerating RGCs in vitro and in vivo are discussed. PMID:10649506
Macular degeneration in an arc welder.
Kim, Eun A; Kim, Byung-Gyu; Yi, Cheol-Ho; Kim, Il Gon; Chae, Chang-Ho; Kang, Seong-Kyu
2007-04-01
A male welder who had been working in an industrial machine plant for more than 20 years experienced acute intense pain in his left eye with continuous lacrimation while performing arc welding in 1997. Later in 1997, at the age of 39 yr, macular edema was found in his left eye. He was diagnosed with macular degeneration (MD) of the left eye in 2002, and with right eye MD in 2004. Radiation in the visible and near infrared (IR) spectra penetrates the eye and is absorbed by the retina, possibly causing thermal or photochemical damage. Such retinal damage may be permanent and, therefore, sight-threatening. The young age and history of an acute painful eye injury are not consistent with age related macular degeneration (AMD) but rather is likely maculopathy caused by welding arc exposure. PMID:17485886
Nonlinear screening effect in an ultrarelativistic degenerate electron-positron gas
Tsintsadze, N. L.; Rasheed, A.; Shah, H. A.; Murtaza, G.
2009-11-15
Nonlinear screening process in an ultrarelativistic degenerate electron-positron gas has been investigated by deriving a generalized nonlinear Poisson equation for the electrostatic potential. In the simple one-dimensional case, the nonlinear Poisson equation leads to Debye-like (Coulomb-like) solutions at distances larger (less) than the characteristic length. When the electrostatic energy is larger than the thermal energy, this nonlinear Poisson equation converts into the relativistic Thomas-Fermi equation whose asymptotic solution in three dimensions shows that the potential field goes to zero at infinity much more slowly than the Debye potential. The possibility of the formation of a bound state in electron-positron plasma is also indicated. Further, it is investigated that the strong spatial fluctuations of the potential field may reduce the screening length and that the root mean square of this spatial fluctuating potential goes to zero for large r rather slowly as compared to the case of the Debye potential.
Calabi-Yau manifolds and their degenerations.
Tosatti, Valentino
2012-07-01
Calabi-Yau manifolds are geometric objects of central importance in several branches of mathematics, including differential geometry, algebraic geometry, and mathematical physics. In this paper, we give a brief introduction to the subject aimed at a general mathematical audience and present some of our results that shed some light on the possible ways in which families of Calabi-Yau manifolds can degenerate. PMID:22257362
Degenerate Bose gases with uniform loss
NASA Astrophysics Data System (ADS)
Grišins, Pjotrs; Rauer, Bernhard; Langen, Tim; Schmiedmayer, Jörg; Mazets, Igor E.
2016-03-01
We theoretically investigate a weakly interacting degenerate Bose gas coupled to an empty Markovian bath. We show that in the universal phononic limit the system evolves towards an asymptotic state where an emergent temperature is set by the quantum noise of the outcoupling process. For situations typically encountered in experiments, this mechanism leads to significant cooling. Such dissipative cooling supplements conventional evaporative cooling and dominates in settings where thermalization is highly suppressed, such as in a one-dimensional quasicondensate.
Effect of trapping in degenerate quantum plasmas
Shah, H. A.; Qureshi, M. N. S.; Tsintsadze, N.
2010-03-15
In the present work we consider the effect of trapping as a microscopic process in a plasma consisting of quantum electrons and nondegenerate ions. The formation of solitary structures is investigated in two cases: first when the electrons are fully degenerate and second when small temperature effects are taken into account. It is seen that not only rarefactive but coupled rarefactive and compressive solitons are obtained under different temperature conditions.
Dichromatic Langmuir waves in degenerate quantum plasma
Dubinov, A. E. Kitayev, I. N.
2015-06-15
Langmuir waves in fully degenerate quantum plasma are considered. It is shown that, in the linear approximation, Langmuir waves are always dichromatic. The low-frequency component of the waves corresponds to classical Langmuir waves, while the high-frequency component, to free-electron quantum oscillations. The nonlinear problem on the profile of dichromatic Langmuir waves is solved. Solutions in the form of a superposition of waves and in the form of beatings of its components are obtained.
Recombination-generation currents in degenerate semiconductors
NASA Technical Reports Server (NTRS)
Von Roos, O.
1978-01-01
The classical Shockley-Read-Hall theory of free carrier recombination and generation via traps is extended to degenerate semiconductors. A concise and simple expression is found which avoids completely the concept of a Fermi level, a concept which is alien to nonequilibrium situations. Assumptions made in deriving the recombination generation current are carefully delineated and are found to be basically identical to those made in the original theory applicable to nondegenerate semiconductors.
Asymmetrical alien hands in corticobasal degeneration.
Fitzgerald, David B; Drago, Valeria; Jeong, Yong; Chang, Yu-Ling; White, Keith D; Heilman, Kenneth M
2007-03-15
There are several forms of alien limb, but alien limb in corticobasal degeneration (CBD) is not well understood. We studied a patient with CBD who demonstrated two different types of alien limb. With his right hand he demonstrated a tactile avoidance response with levitation. With his left hand, he demonstrated continuous tactile pursuit of the examiner's hand ("tactile mitgehen"). Mitgehen is often associated with frontal dysfunction, but avoidance response and levitation are often associated with parietal dysfunction. PMID:17230447
Buoyancy instabilities in degenerate, collisional, magnetized plasmas
NASA Astrophysics Data System (ADS)
Chang, Philip; Quataert, Eliot
2010-03-01
In low-collisionality plasmas, anisotropic heat conduction due to a magnetic field leads to buoyancy instabilities for any non-zero temperature gradient. We study analogous instabilities in degenerate collisional plasmas, i.e. when the electron collision frequency is large compared to the electron cyclotron frequency. Although heat conduction is nearly isotropic in this limit, the small residual anisotropy ensures that collisional degenerate plasmas are also convectively unstable independent of the sign of the temperature gradient. We show that the range of wavelengths that are unstable is independent of the magnetic field strength, while the growth time increases with decreasing magnetic field strength. We discuss the application of these collisional buoyancy instabilities to white dwarfs and neutron stars. Magnetic tension and the low specific heat of a degenerate plasma significantly limit their effectiveness; the most promising venues for growth are in the liquid oceans of young, weakly magnetized neutron stars (B <~ 109 G) and in the cores of young, high magnetic field white dwarfs (B ~ 109 G).
Inertial fusion features in degenerate plasmas
NASA Astrophysics Data System (ADS)
León, Pablo T.; Eliezer, Shalom; Piera, Mireia; Martínez-Val, José M.
2005-04-01
Very high plasma densities can be obtained at the end of the implosion phase in inertial fusion targets, particularly in the so-called fast-ignition scheme (Tabak et al., 1994; Mulser & Bauer, 2004), where a central hot spark is not needed at all. By properly tailoring the fuel compression stage, degenerate states can be reached (Azechi et al., 1991; Nakai et al., 1991; McCory, 1998). In that case, most of the relevant energy transfer mechanisms involving electrons are affected (Honrubia & Tikhonchuk, 2004; Bibi & Matte, 2004; Bibi et al., 2004). For instance, bremsstrahlung emission is highly suppressed (Eliezer et al., 2003). In fact, a low ignition-temperature regime appears at very high plasma densities, due to radiation leakage reduction (León et al., 2001). Stopping power and ion-electron coulomb collisions are also changed in this case, which are important mechanisms to trigger ignition by the incoming fast jet, and to launch the fusion wave from the igniting region into the colder, degenerate plasma. All these points are reviewed in this paper. Although degenerate states would not be easy to obtain by target implosion, they present a very interesting upper limit that deserves more attention in order to complete the understanding on the different domains for inertial confinement fusion.
Propagation of disturbances in degenerate quantum systems
NASA Astrophysics Data System (ADS)
Chancellor, Nicholas; Haas, Stephan
2011-07-01
Disturbances in gapless quantum many-body models are known to travel an unlimited distance throughout the system. Here, we explore this phenomenon in finite clusters with degenerate ground states. The specific model studied here is the one-dimensional J1-J2 Heisenberg Hamiltonian at and close to the Majumdar-Ghosh point. Both open and periodic boundary conditions are considered. Quenches are performed using a local magnetic field. The degenerate Majumdar-Ghosh ground state allows disturbances which carry quantum entanglement to propagate throughout the system and thus dephase the entire system within the degenerate subspace. These disturbances can also carry polarization, but not energy, as all energy is stored locally. The local evolution of the part of the system where energy is stored drives the rest of the system through long-range entanglement. We also examine approximations for the ground state of this Hamiltonian in the strong field limit and study how couplings away from the Majumdar-Ghosh point affect the propagation of disturbances. We find that even in the case of approximate degeneracy, a disturbance can be propagated throughout a finite system.
NASA Astrophysics Data System (ADS)
Ali, S.; Ata-ur-Rahman
2014-04-01
The linear and nonlinear properties of the ion-acoustic (IA) waves are investigated in a relativistically degenerate magnetoplasma, whose constituents are the electrons, positrons, and ions. The electrons and positrons are assumed to obey the Fermi-Dirac statistics, whereas the cold ions are taken to be inertial and magnetized. In linear analysis, various limiting cases are discussed both analytically and numerically. However, for nonlinear studies, the well-known reductive perturbation technique is employed to derive the Zakharov-Kuznetsov and Zakharov-Kuznetsov Burgers equations in the presence of relativistically degenerate electrons and positrons. Furthermore, with the use of hyperbolic tangent method, the equations are simplified to admit the soliton and shock wave solutions. Numerically, it is shown that the amplitude, width, and phase speed associated with the localized IA solitons and shocks are significantly influenced by the various intrinsic plasma parameters relevant to our model. The present analysis can be useful for understanding the collective processes in dense astrophysical environments like neutron stars, where the electrons and positrons are expected to be relativistic and degenerate.
Ali, S.; Ata-ur-Rahman
2014-04-15
The linear and nonlinear properties of the ion-acoustic (IA) waves are investigated in a relativistically degenerate magnetoplasma, whose constituents are the electrons, positrons, and ions. The electrons and positrons are assumed to obey the Fermi-Dirac statistics, whereas the cold ions are taken to be inertial and magnetized. In linear analysis, various limiting cases are discussed both analytically and numerically. However, for nonlinear studies, the well-known reductive perturbation technique is employed to derive the Zakharov-Kuznetsov and Zakharov-Kuznetsov Burgers equations in the presence of relativistically degenerate electrons and positrons. Furthermore, with the use of hyperbolic tangent method, the equations are simplified to admit the soliton and shock wave solutions. Numerically, it is shown that the amplitude, width, and phase speed associated with the localized IA solitons and shocks are significantly influenced by the various intrinsic plasma parameters relevant to our model. The present analysis can be useful for understanding the collective processes in dense astrophysical environments like neutron stars, where the electrons and positrons are expected to be relativistic and degenerate.
NASA Astrophysics Data System (ADS)
Irfan, M.; Ali, S.; Mirza, Arshad M.
2016-02-01
Two-fluid quantum magnetohydrodynamic (QMHD) equations are employed to investigate linear and nonlinear properties of the magnetosonic waves in a semi-relativistic dense plasma accounting for degenerate relativistic electrons. In the linear analysis, a plane wave solution is used to derive the dispersion relation of magnetosonic waves, which is significantly modified due to relativistic degenerate electrons. However, for a nonlinear investigation of solitary and shock waves, we employ the reductive perturbation technique for the derivation of Korteweg-de Vries (KdV) and Korteweg-de Vries Burger (KdVB) equations, admitting nonlinear wave solutions. Numerically, it is shown that the wave frequency decreases to attain a lowest possible value at a certain critical number density Nc(0), and then increases beyond Nc(0) as the plasma number density increases. Moreover, the relativistic electrons and associated pressure degeneracy lead to a reduction in the spatial extents of the magnetosonic waves and a strengthening of the shock amplitude. The results might be important for understanding the linear and nonlinear magnetosonic excitations in dense astrophysical plasmas, such as in white dwarfs, magnetars and neutron stars, etc., where relativistic degenerate electrons are present.
Nonlinear ion-acoustic cnoidal waves in a dense relativistic degenerate magnetoplasma.
El-Shamy, E F
2015-03-01
The complex pattern and propagation characteristics of nonlinear periodic ion-acoustic waves, namely, ion-acoustic cnoidal waves, in a dense relativistic degenerate magnetoplasma consisting of relativistic degenerate electrons and nondegenerate cold ions are investigated. By means of the reductive perturbation method and appropriate boundary conditions for nonlinear periodic waves, a nonlinear modified Korteweg-de Vries (KdV) equation is derived and its cnoidal wave is analyzed. The various solutions of nonlinear ion-acoustic cnoidal and solitary waves are presented numerically with the Sagdeev potential approach. The analytical solution and numerical simulation of nonlinear ion-acoustic cnoidal waves of the nonlinear modified KdV equation are studied. Clearly, it is found that the features (amplitude and width) of nonlinear ion-acoustic cnoidal waves are proportional to plasma number density, ion cyclotron frequency, and direction cosines. The numerical results are applied to high density astrophysical situations, such as in superdense white dwarfs. This research will be helpful in understanding the properties of compact astrophysical objects containing cold ions with relativistic degenerate electrons. PMID:25871222
NASA Astrophysics Data System (ADS)
Viljamaa, Panu; Jacobs, J. Richard; Chris; JamesHyman; Halma, Matthew; EricNolan; Coxon, Paul
2014-07-01
In reply to a Physics World infographic (part of which is given above) about a study showing that Euler's equation was deemed most beautiful by a group of mathematicians who had been hooked up to a functional magnetic-resonance image (fMRI) machine while viewing mathematical expressions (14 May, http://ow.ly/xHUFi).
Some New Aspects of Degenerate Quantum Plasma
Tsintsadze, Nodar L.
2010-12-14
Answers to some salient questions, which arise in quantum plasmas, are given. Starting from the Schroedinger equation for a single particle it is demonstrated how the Wigner-Moyal equation can be derived. It is shown that the Wigner-Moyal type of equation also exists in the classical field theory. As an example, from the Maxwell equations the Wigner-Moyal type of equation is obtained for a dense photon gas, which is classical, concluding that the Wigner-Moyal type of equation can be derived for any system, classical or quantum. A new type of quantum kinetic equations are presented. These novel kinetic equations allows to obtain a set of quantum hydrodynamic equations, which is impossible to derive by the Wigner-Moyal equation. The propagation of small perturbations and instabilities of these perturbations are then discussed, presenting new modes of quantum plasma waves. In the case of low frequency oscillations with ions, a new Bogolyubov type of spectrum is found. Furthermore, the Korteweg-de Vries (KdV) equation is derived and the contribution of the Madelung term in the formation of the KdV solitons is discussed.
Ata-ur-Rahman,; Qamar, A.; Ali, S.; Mirza, Arshad M.
2013-04-15
We have studied the propagation of ion acoustic shock waves involving planar and non-planar geometries in an unmagnetized plasma, whose constituents are non-degenerate ultra-cold ions, relativistically degenerate electrons, and positrons. By using the reductive perturbation technique, Korteweg-deVries Burger and modified Korteweg-deVries Burger equations are derived. It is shown that only compressive shock waves can propagate in such a plasma system. The effects of geometry, the ion kinematic viscosity, and the positron concentration are examined on the ion acoustic shock potential and electric field profiles. It is found that the properties of ion acoustic shock waves in a non-planar geometry significantly differ from those in planar geometry. The present study has relevance to the dense plasmas, produced in laboratory (e.g., super-intense laser-dense matter experiments) and in dense astrophysical objects.
Effects of trapping and finite temperature in a relativistic degenerate plasma
Shah, H. A.; Qureshi, M. N. S.; Masood, W.; Tsintsadze, N. L.
2011-10-15
In the present work, we have undertaken, for the first time, investigation on the effect of trapping on the formation of solitary structures in relativistic degenerate plasmas. Such plasmas have been observed in dense astrophysical objects, and in laboratory these may result due to the interaction of intense lasers with matter. We have used the relativistic Fermi-Dirac distribution to describe the dynamics of the degenerate trapped electrons by solving the kinetic equation. The Sagdeev potential approach has been employed to obtain the arbitrary amplitude solitary structures both when the plasma has been considered cold and when small temperature effects have been taken into account. The theoretical results obtained have been analyzed numerically for different parameter values, and the results have been presented graphically.
NASA Astrophysics Data System (ADS)
Arshad, S.; Shah, H. A.; Qureshi, M. N. S.
2014-07-01
The effect of adiabatic trapping as a microscopic phenomenon in an inhomogeneous degenerate plasma is investigated in the presence of a quantizing magnetic field, and a modified Hasegawa Mima equation for the drift ion-acoustic wave is obtained. The linear dispersion relation in the presence of the quantizing magnetic field is investigated. The modified Hasegawa Mima equation is investigated to obtain bounce frequencies of the trapped particles. The Korteweg-de Vries equation is derived for the two-dimensional case and finally the Sagdeev potential approach is used to obtain solitary structures. The theoretically obtained results have been analyzed numerically for different astrophysical plasma and quantizing magnetic field values.
Development of Multistep and Degenerate Variational Integrators for Applications in Plasma Physics
NASA Astrophysics Data System (ADS)
Ellison, Charles Leland
Geometric integrators yield high-fidelity numerical results by retaining conservation laws in the time advance. A particularly powerful class of geometric integrators is symplectic integrators, which are widely used in orbital mechanics and accelerator physics. An important application presently lacking symplectic integrators is the guiding center motion of magnetized particles represented by non-canonical coordinates. Because guiding center trajectories are foundational to many simulations of magnetically confined plasmas, geometric guiding center algorithms have high potential for impact. The motivation is compounded by the need to simulate long-pulse fusion devices, including ITER, and opportunities in high performance computing, including the use of petascale resources and beyond. This dissertation uses a systematic procedure for constructing geometric integrators --- known as variational integration --- to deliver new algorithms for guiding center trajectories and other plasma-relevant dynamical systems. These variational integrators are non-trivial because the Lagrangians of interest are degenerate - the Euler-Lagrange equations are first-order differential equations and the Legendre transform is not invertible. The first contribution of this dissertation is that variational integrators for degenerate Lagrangian systems are typically multistep methods. Multistep methods admit parasitic mode instabilities that can ruin the numerical results. These instabilities motivate the second major contribution: degenerate variational integrators. By replicating the degeneracy of the continuous system, degenerate variational integrators avoid parasitic mode instabilities. The new methods are therefore robust geometric integrators for degenerate Lagrangian systems. These developments in variational integration theory culminate in one-step degenerate variational integrators for non-canonical magnetic field line flow and guiding center dynamics. The guiding center integrator
1998-11-01
In the late 1950s to early 1960s Rudolph A. Marcus developed a theory for treating the rates of outer-sphere electron-transfer reactions. Outer-sphere reactions are reactions in which an electron is transferred from a donor to an acceptor without any chemical bonds being made or broken. (Electron-transfer reactions in which bonds are made or broken are referred to as inner-sphere reactions.) Marcus derived several very useful expressions, one of which has come to be known as the Marcus cross-relation or, more simply, as the Marcus equation. It is widely used for correlating and predicting electron-transfer rates. For his contributions to the understanding of electron-transfer reactions, Marcus received the 1992 Nobel Prize in Chemistry. This paper discusses the development and use of the Marcus equation. Topics include self-exchange reactions; net electron-transfer reactions; Marcus cross-relation; and proton, hydride, atom and group transfers.
DOE R&D Accomplishments Database
1998-09-21
In the late 1950s to early 1960s Rudolph A. Marcus developed a theory for treating the rates of outer-sphere electron-transfer reactions. Outer-sphere reactions are reactions in which an electron is transferred from a donor to an acceptor without any chemical bonds being made or broken. (Electron-transfer reactions in which bonds are made or broken are referred to as inner-sphere reactions.) Marcus derived several very useful expressions, one of which has come to be known as the Marcus cross-relation or, more simply, as the Marcus equation. It is widely used for correlating and predicting electron-transfer rates. For his contributions to the understanding of electron-transfer reactions, Marcus received the 1992 Nobel Prize in Chemistry. This paper discusses the development and use of the Marcus equation. Topics include self-exchange reactions; net electron-transfer reactions; Marcus cross-relation; and proton, hydride, atom and group transfers.
Beirowski, Bogdan; Adalbert, Robert; Wagner, Diana; Grumme, Daniela S; Addicks, Klaus; Ribchester, Richard R; Coleman, Michael P
2005-01-01
Background The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on statistical observations at discontinuous locations within the nerve, without observing any single axon at two distant points. As axon degeneration is asynchronous, there are clear advantages to longitudinal studies of individual degenerating axons. We recently validated the study of Wallerian degeneration using yellow fluorescent protein (YFP) in a small, representative population of axons, which greatly improves longitudinal imaging. Here, we apply this method to study the progressive nature of Wallerian degeneration in both wild-type and slow Wallerian degeneration (WldS) mutant mice. Results In wild-type nerves, we directly observed partially fragmented axons (average 5.3%) among a majority of fully intact or degenerated axons 37–42 h after transection and 40–44 h after crush injury. Axons exist in this state only transiently, probably for less than one hour. Surprisingly, axons degenerated anterogradely after transection but retrogradely after a crush, but in both cases a sharp boundary separated intact and fragmented regions of individual axons, indicating that Wallerian degeneration progresses as a wave sequentially affecting adjacent regions of the axon. In contrast, most or all WldS axons were partially fragmented 15–25 days after nerve lesion, WldS axons degenerated anterogradely independent of lesion type, and signs of degeneration increased gradually along the nerve instead of abruptly. Furthermore, the first signs of degeneration were short constrictions, not complete breaks. Conclusions We conclude that Wallerian degeneration progresses rapidly along individual wild-type axons after a heterogeneous latent phase. The speed of progression and its ability to travel in either direction challenges earlier models in which clearance of
Degenerate Fermi Gas of {sup 87}Sr
DeSalvo, B. J.; Yan, M.; Mickelson, P. G.; Martinez de Escobar, Y. N.; Killian, T. C.
2010-07-16
We report quantum degeneracy in a gas of ultracold fermionic {sup 87}Sr atoms. By evaporatively cooling a mixture of spin states in an optical dipole trap for 10.5 s, we obtain samples well into the degenerate regime with T/T{sub F}=0.26{sub -0.06}{sup +0.05}. The main signature of degeneracy is a change in the momentum distribution as measured by time-of-flight imaging, and we also observe a decrease in evaporation efficiency below T/T{sub F{approx}}0.5.
Pharmacogenetics and age-related macular degeneration.
Schwartz, Stephen G; Brantley, Milam A
2011-01-01
Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age-related macular degeneration. Most reported data concern polymorphisms in the complement factor H and age-related maculopathy susceptibility 2 genes. At this time, the data are not consistent and no definite conclusions may be drawn. As clinical trials data continue to accumulate, these relationships may become more apparent. PMID:22046503
Family-Specific Degenerate Primer Design: A Tool to Design Consensus Degenerated Oligonucleotides
Goñi, Sandra Elizabeth; Lozano, Mario Enrique
2013-01-01
Designing degenerate PCR primers for templates of unknown nucleotide sequence may be a very difficult task. In this paper, we present a new method to design degenerate primers, implemented in family-specific degenerate primer design (FAS-DPD) computer software, for which the starting point is a multiple alignment of related amino acids or nucleotide sequences. To assess their efficiency, four different genome collections were used, covering a wide range of genomic lengths: Arenavirus (10 × 104 nucleotides), Baculovirus (0.9 × 105 to 1.8 × 105 bp), Lactobacillus sp. (1 × 106 to 2 × 106 bp), and Pseudomonas sp. (4 × 106 to 7 × 106 bp). In each case, FAS-DPD designed primers were tested computationally to measure specificity. Designed primers for Arenavirus and Baculovirus were tested experimentally. The method presented here is useful for designing degenerate primers on collections of related protein sequences, allowing detection of new family members. PMID:23533783
MRI and MR tractography in bilateral hypertrophic olivary degeneration
Sen, Debraj; Gulati, Yoginder S.; Malik, Virender; Mohimen, Aneesh; Sibi, Eranki; Reddy, Deepak Chandra
2014-01-01
Hypertrophic olivary degeneration is a trans-synaptic neuronal degeneration associated with hypertrophy of the inferior olivary nucleus due to a lesion in the triangle of Guillain-Mollaret. Familiarity with this entity on magnetic resonance imaging (MRI) is essential to avoid other erroneous ominous diagnoses. We present a case of bilateral hypertrophic olivary degeneration and discuss the etiopathogenesis and MRI findings in this entity. The contributory role of MR tractography in the diagnosis is also highlighted. PMID:25489133
Changes in ganglion cells during retinal degeneration.
Saha, Susmita; Greferath, Ursula; Vessey, Kirstan A; Grayden, David B; Burkitt, Anthony N; Fletcher, Erica L
2016-08-01
Inherited retinal degeneration such as retinitis pigmentosa (RP) is associated with photoreceptor loss and concomitant morphological and functional changes in the inner retina. It is not known whether these changes are associated with changes in the density and distribution of synaptic inputs to retinal ganglion cells (RGCs). We quantified changes in ganglion cell density in rd1 and age-matched C57BL/6J-(wildtype, WT) mice using the immunocytochemical marker, RBPMS. Our data revealed that following complete loss of photoreceptors, (∼3months of age), there was a reduction in ganglion cell density in the peripheral retina. We next examined changes in synaptic inputs to A type ganglion cells by performing double labeling experiments in mice with the ganglion cell reporter lines, rd1-Thy1 and age-matched wildtype-Thy1. Ribbon synapses were identified by co-labelling with CtBP2 (RIBEYE) and conventional synapses with the clustering molecule, gephyrin. ON RGCs showed a significant reduction in RIBEYE-immunoreactive synapse density while OFF RGCs showed a significant reduction in the gephyrin-immmunoreactive synapse density. Distribution patterns of both synaptic markers across the dendritic trees of RGCs were unchanged. The change in synaptic inputs to RGCs was associated with a reduction in the number of immunolabeled rod bipolar and ON cone bipolar cells. These results suggest that functional changes reported in ganglion cells during retinal degeneration could be attributed to loss of synaptic inputs. PMID:27132232
Nodular fasciitis with degeneration and regression.
Yanagisawa, Akihiro; Okada, Hideki
2008-07-01
Nodular fasciitis is a benign reactive proliferation that is frequently misdiagnosed as a sarcoma. This article describes a case of nodular fasciitis of 6-month duration located in the cheek, which degenerated and spontaneously regressed after biopsy. The nodule was fixed to the zygoma but was free from the overlying skin. The mass was 3.0 cm in diameter and demonstrated high signal intensity on T2-weighted magnetic resonance imaging. A small part of the lesion was biopsied. Pathological and immunohistochemical examinations identified the nodule as nodular fasciitis with myxoid histology. One month after the biopsy, the mass showed decreased signal intensity on T2-weighted images and measured 2.2 cm in size. The signal on T2-weighted images showed time-dependent decreases, and the mass continued to reduce in size throughout the follow-up period. The lesion presented as hypointense to the surrounding muscles on T2-weighted images and was 0.4 cm in size at 2 years of follow-up. This case demonstrates that nodular fasciitis with myxoid histology can change to that with fibrous appearance gradually with time, thus bringing about spontaneous regression. Degeneration may be involved in the spontaneous regression of nodular fasciitis with myxoid appearance. The mechanism of regression, unclarified at present, should be further studied. PMID:18650753
Degenerate parametric oscillation in quantum membrane optomechanics
NASA Astrophysics Data System (ADS)
Benito, Mónica; Sánchez Muñoz, Carlos; Navarrete-Benlloch, Carlos
2016-02-01
The promise of innovative applications has triggered the development of many modern technologies capable of exploiting quantum effects. But in addition to future applications, such quantum technologies have already provided us with the possibility of accessing quantum-mechanical scenarios that seemed unreachable just a few decades ago. With this spirit, in this work we show that modern optomechanical setups are mature enough to implement one of the most elusive models in the field of open system dynamics: degenerate parametric oscillation. Introduced in the eighties and motivated by its alleged implementability in nonlinear optical resonators, it rapidly became a paradigm for the study of dissipative phase transitions whose corresponding spontaneously broken symmetry is discrete. However, it was found that the intrinsic multimode nature of optical cavities makes it impossible to experimentally study the model all the way through its phase transition. In contrast, here we show that this long-awaited model can be implemented in the motion of a mechanical object dispersively coupled to the light contained in a cavity, when the latter is properly driven with multichromatic laser light. We focus on membranes as the mechanical element, showing that the main signatures of the degenerate parametric oscillation model can be studied in state-of-the-art setups, thus opening the possibility of analyzing spontaneous symmetry breaking and enhanced metrology in one of the cleanest dissipative phase transitions. In addition, the ideas put forward in this work would allow for the dissipative preparation of squeezed mechanical states.
Metabolic anatomy of paraneoplastic cerebellar degeneration
Anderson, N.E.; Posner, J.B.; Sidtis, J.J.; Moeller, J.R.; Strother, S.C.; Dhawan, V.; Rottenberg, D.A.
1988-06-01
Eleven patients with acquired cerebellar degeneration (10 of whom had paraneoplastic cerebellar degeneration (PCD)) were evaluated using neuropsychological tests and /sup 18/F-fluorodeoxyglucose/positron emission tomography to (1) quantify motor, cognitive, and metabolic abnormalities; (2) determine if characteristic alterations in the regional cerebral metabolic rate for glucose (rCMRGlc) are associated with PCD; and (3) correlate behavioral and metabolic measures of disease severity. Eighteen volunteer subjects served as normal controls. Although some PCD neuropsychological test scores were abnormal, these results could not, in general, be dissociated from the effects of dysarthria and ataxia. rCMRGlc was reduced in patients with PCD (versus normal control subjects) in all regions except the brainstem. Analysis of patient and control rCMRGlc data using a mathematical model of regional metabolic interactions revealed two metabolic pattern descriptors, SSF1 and SSF2, which distinguished patients with PCD from normal control subjects; SSF2, which described a metabolic coupling between cerebellum, cuneus, and posterior temporal, lateral frontal, and paracentral cortex, correlated with quantitative indices of cerebellar dysfunction. Our inability to document substantial intellectual impairment in 7 of 10 patients with PCD contrasts with the 50% incidence of dementia in PCD reported by previous investigators. Widespread reductions in PCD rCMRGlc may result from the loss of cerebellar efferents to thalamus and forebrain structures, a reverse cerebellar diaschisis.
Progressive retinal degeneration in ranch mink.
Hadlow, W J
1984-01-01
Retinal degeneration was prevalent in a large group of sapphire and pastel mink (Mustela vison) kept for studies on slow viral diseases. Nearly 78% of those two to eight years old were affected. The retinopathy was equally common in both sexes but more frequent in sapphires (85%) than in pastels (63%), and it was severe more often in sapphires than in pastels. By light microscopy, the primary change appeared to be progressive degeneration of fully developed photoreceptors, beginning in their outer segments. In many mink, including some younger ones, the rods and cones and outer nuclear layer had disappeared from all but the far periphery of the fundus. The inner retinal layers were spared until late in the disease, and the pigment epithelium remained essentially unchanged. The cause of the retinopathy was not established. It may represent an abiotrophy in which the structural integrity of the photoreceptors began to wane in many mink after they reached two years of age. Apart from reducing visual acuity, the retinopathy has implications for the photoperiodic control of fur growth and reproduction in this highly light-sensitive carnivore. PMID:6710807
Nearly degenerate electron distributions and superluminal radiation densities
NASA Astrophysics Data System (ADS)
Tomaschitz, Roman
2010-02-01
Polylogarithmic fugacity expansions of the partition function, the caloric and thermal equations of state, and the specific heat of fermionic power-law distributions are derived in the nearly degenerate low-temperature/high-density quantum regime. The spectral functions of an ultra-relativistic electron plasma are obtained by averaging the tachyonic radiation densities of inertial electrons with Fermi power-laws, whose entropy is shown to be extensive and stable. The averaged radiation densities are put to test by performing tachyonic cascade fits to the γ-ray spectrum of the TeV blazar Markarian 421 in a low and high emission state. Estimates of the thermal electron plasma in this active galactic nucleus are extracted from the spectral fits, such as temperature, number count, and internal energy. The tachyonic cascades reproduce the quiescent as well as a burst spectrum of the blazar obtained with imaging atmospheric Cherenkov detectors. Double-logarithmic plots of the differential tachyon flux exhibit intrinsic spectral curvature, caused by the Boltzmann factor of the electron gas.
Stimulated degenerate four-wave mixing in Si nanocrystal waveguides
NASA Astrophysics Data System (ADS)
Manna, Santanu; Bernard, Martino; Biasi, Stefano; Ramiro Manzano, Fernando; Mancinelli, Mattia; Ghulinyan, Mher; Pucker, George; Pavesi, Lorenzo
2016-07-01
Parametric frequency conversion via four-wave mixing (FWM) in silicon nanocrystal (Si NC) waveguides is observed at 1550 nm. To investigate the role of Si NC, different types of waveguides containing Si NC in a SiO2 matrix were fabricated. Owing to the increase of the dipole oscillator strength mediated by the quantum confinement effect, the non-linear refractive index ({n}2) of Si NCs is found to be more than one order of magnitude larger than the one of bulk Si. Coupled differential equations for the degenerate FWM process taking into account the role of Si NC were numerically solved to model the experimental data. The modeling yields an effective {n}2 for Si NCs in SiO2 waveguides which is similar to the one of Si waveguides. We also measured a large signal to idler conversion bandwidth of ∼22 nm. The large non-linear refractive index is joined with a large two photon absorption coefficient which makes the use of Si NC in non-linear optical devices mostly suitable for mid-infrared applications.
Quantum correlation in degenerate optical parametric oscillators with mutual injections
NASA Astrophysics Data System (ADS)
Takata, Kenta; Marandi, Alireza; Yamamoto, Yoshihisa
2015-10-01
We theoretically and numerically study the quantum dynamics of two degenerate optical parametric oscillators with mutual injections. The cavity mode in the optical coupling path between the two oscillator facets is explicitly considered. Stochastic equations for the oscillators and mutual injection path based on the positive P representation are derived. The system of two gradually pumped oscillators with out-of-phase mutual injections is simulated, and its quantum state is investigated. When the incoherent loss of the oscillators other than the mutual injections is small, the squeezed quadratic amplitudes p ̂ in the oscillators are positively correlated near the oscillation threshold. It indicates finite quantum correlation, estimated via Gaussian quantum discord, and the entanglement between the intracavity subharmonic fields. When the loss in the injection path is low, each oscillator around the phase transition point forms macroscopic superposition even under a small pump noise. It suggests that the squeezed field stored in the low-loss injection path weakens the decoherence in the oscillators.
Rehman, M. A.; Qureshi, M. N. S.; Shah, H. A.; Masood, W.
2015-10-15
Nonlinear circularly polarized Alfvén waves are studied in magnetized nonrelativistic, relativistic, and ultrarelativistic degenerate Fermi plasmas. Using the quantum hydrodynamic model, Zakharov equations are derived and the Sagdeev potential approach is used to investigate the properties of the electromagnetic solitary structures. It is seen that the amplitude increases with the increase of electron density in the relativistic and ultrarelativistic cases but decreases in the nonrelativistic case. Both right and left handed waves are considered, and it is seen that supersonic, subsonic, and super- and sub-Alfvénic solitary structures are obtained for different polarizations and under different relativistic regimes.
Chau, W.Y.; Lake, K.; Stone, J.
1984-06-15
The Oppenheimer-Volkoff equations for isothermal, partially degenerate neutral lepton configurations have been solved numerically for arbitrary temperature and degree of degeneracy. For the specific case where the leptons are massive neutrions (approx.30 eV) with properties quite tightly constrained by cosmological considerations, we find that it possible to have a neutrino halo surrounding a normal galaxy with the right values of mass and radius required of the ''invisible halo'' in the missing mass problem. The density distribution, however, yields a rotational curve which, with the present chosen values of parameters, does not fit the observations for spiral galaxies.
Relativistic theory for localized electrostatic excitations in degenerate electron-ion plasmas.
Mc Kerr, Michael; Haas, Fernando; Kourakis, Ioannis
2014-09-01
A self-consistent relativistic two-fluid model is proposed for electron-ion plasma dynamics. A one-dimensional geometry is adopted. Electrons are treated as a relativistically degenerate fluid, governed by an appropriate equation of state. The ion fluid is also allowed to be relativistic, but is cold, nondegenerate, and subject only to an electrostatic potential. Exact stationary-profile solutions are sought, at the ionic scale, via the Sagdeev pseudopotential method. The analysis provides the pulse existence region, in terms of characteristic relativistic parameters, associated with the (ultrahigh) particle density. PMID:25314552
ION SOLITARY PULSES IN WARM PLASMAS WITH ULTRARELATIVISTIC DEGENERATE ELECTRONS AND POSITRONS
Zeba, I.; Moslem, W. M.; Shukla, P. K. E-mail: zeba.israr@rub.de E-mail: wmm@tp4.rub.de
2012-05-01
The nonlinear propagation of ion solitary pulses in a warm collisionless electron-positron-ion plasma with ultrarelativistic degenerate electrons and positrons has been investigated. Arbitrary and small- (but finite-) amplitude ion solitary pulses are investigated by deriving the Korteweg-de Vries equation and an energy-balance-like expression involving a Sagdeev-like pseudopotential. The existence regions for ion solitary pulses have been precisely defined and numerically investigated. The ion solitary pulse profiles are also displayed. Applications to the interior of white dwarf stars and the corona of magnetars are discussed.
Hussain, S.; Mahmood, S.; Rehman, Aman-ur-
2014-11-15
Linear and nonlinear propagation of magnetosonic waves in the perpendicular direction to the ambient magnetic field is studied in dense plasmas for non-relativistic and ultra-relativistic degenerate electrons pressure. The sources of nonlinearities are the divergence of the ions and electrons fluxes, Lorentz forces on ions and electrons fluids and the plasma current density in the system. The Korteweg-de Vries equation for magnetosonic waves propagating in the perpendicular direction of the magnetic field is derived by employing reductive perturbation method for non-relativistic as well as ultra-relativistic degenerate electrons pressure cases in dense plasmas. The plots of the magnetosonic wave solitons are also shown using numerical values of the plasma parameters such a plasma density and magnetic field intensity of the white dwarfs from literature. The dependence of plasma density and magnetic field intensity on the magnetosonic wave propagation is also pointed out in dense plasmas for both non-relativistic and ultra-relativistic degenerate electrons pressure cases.
The double-degenerate, super-Chandrasekhar nucleus of the planetary nebula Henize 2-428.
Santander-García, M; Rodríguez-Gil, P; Corradi, R L M; Jones, D; Miszalski, B; Boffin, H M J; Rubio-Díez, M M; Kotze, M M
2015-03-01
The planetary nebula stage is the ultimate fate of stars with masses one to eight times that of the Sun (M(⊙)). The origin of their complex morphologies is poorly understood, although several mechanisms involving binary interaction have been proposed. In close binary systems, the orbital separation is short enough for the primary star to overfill its Roche lobe as the star expands during the asymptotic giant branch phase. The excess gas eventually forms a common envelope surrounding both stars. Drag forces then result in the envelope being ejected into a bipolar planetary nebula whose equator is coincident with the orbital plane of the system. Systems in which both stars have ejected their envelopes and are evolving towards the white dwarf stage are said to be double degenerate. Here we report that Henize 2-428 has a double-degenerate core with a combined mass of ∼1.76M(⊙), which is above the Chandrasekhar limit (the maximum mass of a stable white dwarf) of 1.4M(⊙). This, together with its short orbital period (4.2 hours), suggests that the system should merge in 700 million years, triggering a type Ia supernova event. This supports the hypothesis of the double-degenerate, super-Chandrasekhar evolutionary pathway for the formation of type Ia supernovae. PMID:25686608
A COMPUTATIONAL MODEL OF MOTOR NEURON DEGENERATION
Le Masson, Gwendal; Przedborski, Serge; Abbott, L.F.
2014-01-01
SUMMARY To explore the link between bioenergetics and motor neuron degeneration, we used a computational model in which detailed morphology and ion conductance are paired with intracellular ATP production and consumption. We found that reduced ATP availability increases the metabolic cost of a single action potential and disrupts K+/Na+ homeostasis, resulting in a chronic depolarization. The magnitude of the ATP shortage at which this ionic instability occurs depends on the morphology and intrinsic conductance characteristic of the neuron. If ATP shortage is confined to the distal part of the axon, the ensuing local ionic instability eventually spreads to the whole neuron and involves fasciculation-like spiking events. A shortage of ATP also causes a rise in intracellular calcium. Our modeling work supports the notion that mitochondrial dysfunction can account for salient features of the paralytic disorder amyotrophic lateral sclerosis, including motor neuron hyperexcitability, fasciculation, and differential vulnerability of motor neuron subpopulations. PMID:25088365
[Epidemiology of age-related macular degeneration].
Brandl, C; Stark, K J; Wintergerst, M; Heinemann, M; Heid, I M; Finger, R P
2016-09-01
Age-related macular degeneration (AMD) is the main cause of blindness in industrialized societies. Population-based epidemiological investigations generate important data on prevalence, incidence, risk factors, and future trends. This review summarizes the most important epidemiological studies on AMD with a focus on their transferability to Germany including existing evidence for the main risk factors for AMD development and progression. Future tasks, such as the standardization of grading systems and the use of recent retinal imaging technology in epidemiological studies are discussed. In Germany, epidemiological data on AMD are scarce. However, the need for epidemiological research in ophthalmology is currently being addressed by several recently started population-based studies. PMID:27541733
Therapeutic interventions in parkinsonism: Corticobasal degeneration.
Marsili, Luca; Suppa, Antonio; Berardelli, Alfredo; Colosimo, Carlo
2016-01-01
Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder resulting from pathological accumulation of tau protein and is included in the spectrum of Atypical Parkinsonism. The typical clinical phenotype of CBD is characterized by the Corticobasal syndrome (CBS). In recent years it has become clear that the clinical picture of CBS may be caused by different pathological conditions, resulting in frequent misdiagnosis. CBD has high morbidity and poor prognosis with no effective therapies. In this review, we will discuss the symptomatic treatment, the palliative care and the disease modifying strategies currently in use. Symptomatic treatment in patients with CBD may sometimes be useful for improving motor (parkinsonism, dystonia and myoclonus) and non-motor (cognitive-behavioral) symptoms, but the effects are often unsatisfactory. In addition, non-pharmacological strategies and palliative care are useful integrating components of the multidisciplinary therapeutic approach for patients with CBD. Despite many efforts, a disease-modifying treatment is still unavailable for CBD. PMID:26382843
Cartilage degeneration in different human joints.
Kuettner, K E; Cole, A A
2005-02-01
Variations among joints in the initiation and progression of degeneration may be explained, in part, by metabolic, biochemical and biomechanical differences. Compared to the cartilage in the knee joint, ankle cartilage has a higher content of proteoglycans and water, as well as an increased rate of proteoglycan turnover and synthesis, all of which are responsible for its increased stiffness and reduced permeability. Chondrocytes within ankle cartilage have a decreased response to catabolic factors such as interleukin-1 and fibronectin fragments, compared to the chondrocytes of knee cartilage. Moreover, in response to damage, ankle chondrocytes synthesize proteoglycans at a higher rate than that found in knee cartilage chondrocytes, which suggests a greater capacity for repair. In addition to the cartilages of the two joints, the underlying bones also respond differently to degenerative changes. Taken together, these metabolic, biochemical and biomechanical differences may provide protection to the ankle. PMID:15694570
The muon g - 2 and degenerate supersymmetry
NASA Astrophysics Data System (ADS)
Chowdhury, Debtosh; Patel, Ketan M.; Tata, Xerxes; Vempati, Sudhir K.
2016-04-01
A degenerate supersymmetric particle spectrum can escape constraints from flavor physics and at the same time evade limits from the direct searches. If such a spectrum is light enough, it can also account for the observed value of the anomalous magnetic moment of the muon. Inspired by this, we consider a scenario where all the soft terms have approximately a common mass scale while allowing for small splittings. We study this scenario considering the constraints from Higgs mass, various B meson decays and the dark matter relic density. We find that, with superpartners ~ 800 - 1000 GeV, it is still possible to escape the present limits from the first run of LHC and flavor physics and can account for muon g - 2 within 2σ.
Quantum Walk in Degenerate Spin Environments
NASA Astrophysics Data System (ADS)
Carlström, Johan; Prokof'ev, Nikolay; Svistunov, Boris
2016-06-01
We study the propagation of a hole in degenerate (paramagnetic) spin environments. This canonical problem has important connections to a number of physical systems, and is perfectly suited for experimental realization with ultracold atoms in an optical lattice. At the short-to-intermediate time scale that we can access using a stochastic-series-type numeric scheme, the propagation turns out to be distinctly nondiffusive with the probability distribution featuring minima in both space and time due to quantum interference, yet the motion is not ballistic, except at the beginning. We discuss possible scenarios for long-term evolution that could be explored with an unprecedented degree of detail in experiments with single-atom resolved imaging.
Spectroscopic temperature determination of degenerate Fermi gases
Kostrun, Marijan; Cote, Robin
2003-12-01
We suggest a simple method for measuring the temperature of ultracold gases made of fermions. We show that by using a two-photon Raman probe, it is possible to obtain line shapes which reveal properties of the degenerate sample, notably its temperature T. The proposed method could be used with identical fermions in different hyperfine states interacting via s-wave scattering or identical fermions in the same hyperfine state via p-wave scattering. We illustrate the applicability of the method in realistic conditions for {sup 6}Li prepared in two different hyperfine states. We find that temperatures down to 0.05T{sub F} can be determined by this in situ method.
Subwavelength total acoustic absorption with degenerate resonators
NASA Astrophysics Data System (ADS)
Yang, Min; Meng, Chong; Fu, Caixing; Li, Yong; Yang, Zhiyu; Sheng, Ping
2015-09-01
We report the experimental realization of perfect sound absorption by sub-wavelength monopole and dipole resonators that exhibit degenerate resonant frequencies. This is achieved through the destructive interference of two resonators' transmission responses, while the matching of their averaged impedances to that of air implies no backscattering, thereby leading to total absorption. Two examples, both using decorated membrane resonators (DMRs) as the basic units, are presented. The first is a flat panel comprising a DMR and a pair of coupled DMRs, while the second one is a ventilated short tube containing a DMR in conjunction with a sidewall DMR backed by a cavity. In both examples, near perfect absorption, up to 99.7%, has been observed with the airborne wavelength up to 1.2 m, which is at least an order of magnitude larger than the composite absorber. Excellent agreement between theory and experiment is obtained.
Degenerate R-S perturbation theory
NASA Technical Reports Server (NTRS)
Hirschfelder, J. O.; Certain, P. R.
1973-01-01
A concise, systematic procedure is given for determining the Rayleigh-Schrodinger energies and wave functions of degenerate states to arbitrarily high orders even when the degeneracies of the various states are resolved in arbitrary orders. The procedure is expressed in terms of an iterative cycle in which the energy through the (2n+1)st order is expressed in terms of the partially determined wave function through the n-th order. Both a direct and an operator derivation are given. The two approaches are equivalent and can be transcribed into each other. The direct approach deals with the wave functions (without the use of formal operators) and has the advantage that it resembles the usual treatment of nondegenerate perturbations and maintains close contact with the basic physics. In the operator approach, the wave functions are expressed in terms of infinite order operators which are determined by the successive resolution of the space of the zeroth order functions.
MicroRNA in intervertebral disc degeneration.
Li, Zheng; Yu, Xin; Shen, Jianxiong; Chan, Matthew T V; Wu, William Ka Kei
2015-06-01
Aetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental, biochemical and biomechanical factors contributing to the disease process. It is becoming obvious that epigenetic processes influence evolution of IDD as strongly as the genetic background. Deregulated phenotypes of nucleus pulposus cells, including differentiation, migration, proliferation and apoptosis, are involved in all stages of progression of human IDD. Non-coding RNAs, including microRNAs, have recently been recognized as important regulators of gene expression. Research into roles of microRNAs in IDD has been very active over the past 5 years. Our review summarizes current research enlightenment towards understanding roles of microRNAs in regulating nucleus pulposus cell functions in IDD. These exciting findings support the notion that specific modulation of microRNAs may represent an attractive approach for management of IDD. PMID:25736871
Age-related macular degeneration: current treatments
Hubschman, Jean Pierre; Reddy, Shantan; Schwartz, Steven D
2009-01-01
Purpose: Although important progress has been made in understanding age-related macular degeneration (AMD), management of the disease continues to be a challenge. AMD research has led to a widening of available treatment options and improved prognostic perspectives. This essay reviews these treatment options. Design: Interpretative essay. Methods: Literature review and interpretation. Results: Current treatments to preserve vision in patients with non-exudative AMD include antioxidant vitamins and mineral supplementations. Exudative AMD is currently most often treated monthly with anti-VEGF intravitreal injections. However, investigators are beginning to experiment with combination therapy and surgical approaches in an attempt to limit the number of treatment and reduce the financial burden on the health care system. Conclusion: By better understanding the basis and pathogenesis of AMD, newer therapies will continue to be developed that target specific pathways in patients with AMD, with the hoped for outcome of better management of the disease and improved visual acuity. PMID:19668560
Topological superradiance in a degenerate Fermi gas
NASA Astrophysics Data System (ADS)
Pan, Jian-Song; Liu, Xiong-Jun; Zhang, Wei; Yi, Wei; Guo, Guang-Can; Yi's Group Team; Liu's Group Team; Zhang's Group Team
2015-05-01
We predict the existence of a topological superradiant state in a two-component degenerate Fermi gas in a cavity. The superradiant light generation in the transversely driven cavity mode induces a cavity-assisted spin-orbit coupling in the system and opens a bulk gap at half filling. This mechanism can simultaneously drive a topological phase transition in the system, yielding a topological superradiant state. We map out the steady-state phase diagram of the system in the presence of an effective Zeeman field, and identify a critical tetracritical point beyond which the topological and the conventional superraidiant phase boundaries separate. We propose to detect the topological phase transition based on its signatures in either the momentum distribution of the atoms or in the cavity photon occupation.
9 CFR 311.35 - Muscular inflammation, degeneration, or infiltration.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Muscular inflammation, degeneration, or infiltration. 311.35 Section 311.35 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... PARTS § 311.35 Muscular inflammation, degeneration, or infiltration. (a) If muscular lesions are...
9 CFR 311.35 - Muscular inflammation, degeneration, or infiltration.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Muscular inflammation, degeneration, or infiltration. 311.35 Section 311.35 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... PARTS § 311.35 Muscular inflammation, degeneration, or infiltration. (a) If muscular lesions are...
[Depression in Patients with Age-Related Macular Degeneration].
Narváez, Yamile Reveiz; Gómez-Restrepo, Carlos
2012-09-01
Age-related macular degeneration is a cause for disability in the elderly since it greatly affects their quality of life and increases depression likelihood. This article discusses the negative effect depression has on patients with age-related macular degeneration and summarizes the interventions available for decreasing their depression index. PMID:26572116
9 CFR 311.35 - Muscular inflammation, degeneration, or infiltration.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Muscular inflammation, degeneration, or infiltration. 311.35 Section 311.35 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... PARTS § 311.35 Muscular inflammation, degeneration, or infiltration. (a) If muscular lesions are...
9 CFR 311.35 - Muscular inflammation, degeneration, or infiltration.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Muscular inflammation, degeneration, or infiltration. 311.35 Section 311.35 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... PARTS § 311.35 Muscular inflammation, degeneration, or infiltration. (a) If muscular lesions are...
9 CFR 311.35 - Muscular inflammation, degeneration, or infiltration.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Muscular inflammation, degeneration, or infiltration. 311.35 Section 311.35 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... PARTS § 311.35 Muscular inflammation, degeneration, or infiltration. (a) If muscular lesions are...
Retinas in a Dish Peek into Inherited Retinal Degeneration.
Duong, Thu T; Vasireddy, Vidyullatha; Mills, Jason A; Bennett, Jean
2016-06-01
Human retinal degeneration can cause blindness, and the lack of relevant model systems has made identifying underlying mechanisms challenging. Parfitt et al. (2016) generate three-dimensional retinal tissue from patient-derived induced pluripotent stem cells to identify how CEP290 mutations cause retinal degeneration, and show an antisense approach can correct disease-associated phenotypes. PMID:27257755
Does lumbar facet arthrosis precede disc degeneration? A postmortem study.
Eubanks, Jason David; Lee, Michael J; Cassinelli, Ezequiel; Ahn, Nicholas U
2007-11-01
It is believed lumbar degeneration begins in the disc, where desiccation and collapse lead to instability and compensatory facet arthrosis. We explored the contrary contention that facet degeneration precedes disc degeneration by examining 647 skeletal lumbar spines. Using facet osteophytosis as a measure of facet degeneration and vertebral rim osteophytosis as a measure of disc degeneration, we assumed bone degeneration in both locations equally reflected the progression of those in the soft tissues. We graded arthrosis Grade 0 to 4 on a continuum from no arthritis to ankylosis. The data were analyzed for different age groups to examine patterns of degeneration with age. Specimens younger than 30 years of age had a higher prevalence of facet osteophytosis compared with vertebral rim osteophotosis at L1-L2 and L2-L3. Specimens aged 30 to 39 years showed more facet osteophytosis than vertebral rim osteophytosis at L4-L5. Specimens older than 40 years, however, showed more vertebral rim osteophytosis compared with facet osteophytosis at all levels except L4-L5 and L5-S1. This skeletal study suggests facet osteophytosis appears early in the degenerative process, preceding vertebral rim osteophytosis of degenerating intervertebral discs. However, once facets begin deteriorating with age, vertebral rim osteophytosis overtakes continued facet osteophytosis. These data challenge the belief that facet osteophytosis follows vertebral rim osteophytosis; rather, it appears vertebral rim osteophytosis progresses more rapidly in later years, but facet osteophotosis occurs early, predominating in younger individuals. PMID:17767079
Transurethral resection and degeneration of bladder tumour
Li, Aihua; Fang, Wei; Zhang, Feng; Li, Weiwu; Lu, Honghai; Liu, Sikuan; Wang, Hui; Zhang, Binghui
2013-01-01
Introduction: We evaluate the efficacy and safety of transurethral resection and degeneration of bladder tumour (TURD-Bt). Methods: In total, 56 patients with bladder tumour were treated by TURD-Bt. The results in these patients were compared with 32 patients treated by current transurethral resection of bladder tumour (TUR-Bt). Patients with or without disease progressive factors were respectively compared between the 2 groups. The factors included recurrent tumour, multiple tumours, tumour ≥3 cm in diameter, clinical stage T2, histological grade 3, adenocarcinoma, and ureteral obstruction or hydronephrosis. Results: Follow-up time was 48.55 ± 23.74 months in TURD-Bt group and 56.28 ± 17.61 months in the TUR-Bt group (p > 0.05). In patients without progressive factors, no tumour recurrence was found and overall survival was 14 (100%) in the TURD-Bt group; 3 (37.50%) patients had recurrence and overall survival was 5 (62.5%) in the TUR-Bt group. In patients with progressive factors, 8 (19.05%) patients had tumour recurrence, overall survival was 32 (76.19%) and cancer death was 3 (7.14%) in TURD-Bt group; 18 (75.00%) patients had tumour recurrence (p < 0.05), overall survival was 12 (50.00%) (p < 0.01) and cancer death was 8 (33.33%) (p < 0.05) in TUR-Bt group. No significant complication was found in TURD-Bt group. Conclusion: This study suggests that complete resection and degeneration of bladder tumour can be expected by TURD-Bt. The surgical procedure is safe and efficacious, and could be predictable and controllable before and during surgery. We would conclude that for bladder cancers without lymph node metastasis and distal metastasis, TURD-Bt could be performed to replace radical TUR-Bt and preserve the bladder. PMID:24475002
Ouabain-induced cochlear degeneration in rat
Fu, Yong; Ding, Dalian; Jiang, Haiyan; Salvi, Richard
2012-01-01
Ouabain, an potent inhibitor of the Na+/K+-ATPase pump, selectively destroys spiral ganglion neurons (SGNs) in gerbils and mice whereas in guinea pigs it preferentially damages cochlear hair cells. To elucidate the effects of ouabain on the rat inner ear, a species widely used in research, 5 µl of 1 mM or 10 mM ouabain was applied to the round window membrane. Distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) were used identify functional deficits in hair cells and neurons respectively and histological techniques were used to characterize cochlear pathologies. High-frequency ABR thresholds were elevated after treatment with 1 mM ouabain whereas DPOAEs remained normal. In contrast, 10 mM ouabain increased ABR thresholds and reduced DPOAE amplitudes. Consistent with the physiological changes, 1 mM ouabain only damaged the SGNs and auditory nerve fibers in the basal turn of the cochlea whereas 10 mM ouabain destroyed both SGNs and cochlear hair cells; damage was greatest near the base and decreased toward the apex. The nuclei of degenerating SGNs and hair cells were condensed and fragmented and many cells were TUNEL-positive, morphological features of apoptotic cell death. Thus, ouabain-induced cochlear degeneration in rats is apoptotic and concentration dependent; low concentrations preferentially damage SGNs in the base of the cochlea, producing an animal model of partial auditory neuropathy, whereas high concentrations damage both hair cells and SGNs with damage decreasing from the base towards the apex. PMID:22476946
Crystallization and collapse in relativistically degenerate matter
Akbari-Moghanjoughi, M.
2013-04-15
In this paper, it is shown that a mass density limit exists beyond which the relativistically degenerate matter would crystallize. The mass density limit, found here, is quite analogous to the mass limit predicted by Chandrasekhar for a type of compact stars called white dwarfs (M{sub Ch} Asymptotically-Equal-To 1.43 Solar Mass). In this study, the old problem of white dwarf core collapse, which has been previously investigated by Chandrasekhar using hydrostatic stability criteria, is revisited in the framework of the quantum hydrodynamics model by inspection of the charge screening at atomic scales in the relativistic degeneracy plasma regime taking into account the relativistic Fermi-Dirac statistics and electron interaction features such as the quantum statistical pressure, Coulomb attraction, electron exchange-correlation, and quantum recoil effects. It is revealed that the existence of ion correlation and crystallization of matter in the relativistically degenerate plasma puts a critical mass density limit on white dwarf core region. It is shown that a white dwarf star with a core mass density beyond this critical limit can undergo the spontaneous core collapse (SCC). The SCC phenomenon, which is dominantly caused by the electron quantum recoil effect (interference and localization of the electron wave function), leads to a new exotic state of matter. In such exotic state, the relativistic electron degeneracy can lead the white dwarf crystallized core to undergo the nuclear fusion and an ultimate supernova by means of the volume reduction (due to the enhanced compressibility) and huge energy release (due to the increase in cohesive energy), under the stars huge inward gravitational pressure. Moreover, it is found that the SCC phenomenon is significantly affected by the core composition (it is more probable for heavier plasmas). The critical mass density found here is consistent with the values calculated for core density of typical white dwarf stars.
Ouabain-induced cochlear degeneration in rat.
Fu, Yong; Ding, Dalian; Jiang, Haiyan; Salvi, Richard
2012-08-01
Ouabain, a potent inhibitor of the Na+/K+-ATPase pump, selectively destroys spiral ganglion neurons (SGNs) in gerbils and mice, whereas in guinea pigs it preferentially damages cochlear hair cells. To elucidate the effects of ouabain on the rat inner ear, a species widely used in research, 5 μl of 1 or 10 mM ouabain was applied to the round window membrane. Distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) were used to identify functional deficits in hair cells and neurons, respectively, and histological techniques were used to characterize cochlear pathologies. High-frequency ABR thresholds were elevated after treatment with 1 mM ouabain, whereas DPOAEs remained normal. In contrast, 10 mM ouabain increased ABR thresholds and reduced DPOAE amplitudes. Consistent with the physiological changes, 1 mM ouabain only damaged the SGNs and auditory nerve fibers in the basal turn of the cochlea whereas 10 mM ouabain destroyed both SGNs and cochlear hair cells; damage was greatest near the base and decreased toward the apex. The nuclei of degenerating SGNs and hair cells were condensed and fragmented and many cells were TUNEL-positive, morphological features of apoptotic cell death. Thus, ouabain-induced cochlear degeneration in rats is apoptotic and concentration dependent; low concentrations preferentially damage SGNs in the base of the cochlea, producing an animal model of partial auditory neuropathy, whereas high concentrations damage both hair cells and SGNs with damage decreasing from the base toward the apex. PMID:22476946
Preservation of retinotopic map in retinal degeneration.
Xie, John; Wang, Gene-Jack; Yow, Lindy; Humayun, Mark S; Weiland, James D; Cela, Carlos J; Jadvar, Hossein; Lazzi, Gianluca; Dhrami-Gavazi, Elona; Tsang, Stephen H
2012-05-01
Retinal degenerations trigger the loss of photoreceptors and cause the remaining de-afferented neural retina to undergo remodeling. Concerns over this potential retinal synaptic reorganization following visual loss have raised questions regarding the usefulness of visual restoration via retinal electrical stimulation. We have used quantitative positron emission tomography (PET) and 2-deoxy-2-[18F]fluoro-d-glucose (FDG) to objectively evaluate the connection between the retina and the primary visual cortex under both light and transcorneal electrical stimulation (TcES) in five subjects with retinal degeneration (RD) who have had more than ten years of light-perception-only best visual acuity and five age-matched normal-sighted controls. All subjects underwent quantitative PET with FDG as the metabolic tracer during stimulation of the right eye under both light stimulation condition and transcorneal electrical stimulation (TcES) using ERG-Jet contact lens electrode. Cortical activation maps from each stimulation condition were obtained using statistical parametric mapping. TcES phosphene threshold current and qualitative visual cortex activation from both stimulation conditions were compared between the two subject groups. Average phosphene threshold current was 0.72 ± 0.18 mA for the five normal-sighted controls and 3.08 ± 2.01 mA for the retinal degenerative subjects. Phosphene threshold current was significantly higher in retinal degenerative subjects compared to normal-sighted controls (p < 0.05). We found both light stimulation and TcES resulted in retinotopically mapped primary visual cortex activation in both groups. In addition, the patterns of early visual area activation between the two subject groups are more similar during TcES than light stimulation. Our findings suggest primary visual cortex continues to maintain its retinotopy in RD subjects despite prolonged visual loss. PMID:22685713
Retrograde Axonal Degeneration in Parkinson Disease
Tagliaferro, Patricia; Burke, Robert E.
2016-01-01
In spite of tremendous research efforts we have not yet achieved two of our principal therapeutic goals in the treatment of Parkinson’s disease (PD), to prevent its onward progression and to provide restoration of systems that have already been damaged by the time of diagnosis. There are many possible reasons for our inability to make progress. One possibility is that our efforts thus far may not have been directed towards the appropriate cellular compartments. Up until now research has been largely focused on the loss of neurons in the disease. Thus, neuroprotection approaches have been largely aimed at blocking mechanisms that lead to destruction of the neuronal cell body. Attempts to provide neurorestoration have been almost entirely focused on replacement of neurons. We herein review the evidence that the axonal component of diseased neuronal systems merit more of our attention. Evidence from imaging studies, from postmortem neurochemical studies, and from genetic animal models suggests that the axons of the dopaminergic system are involved predominantly and early in PD. Since the mechanisms of axonal destruction are distinct from those of neuron cell body degeneration, a focus on axonal neurobiology will offer new opportunities for preventing their degeneration. At present these mechanisms remain largely obscure. However, defining them is likely to offer new opportunities for neuroprotection. In relation to neurorestoration, while it has been classically believed that neurons of the adult central nervous system are incapable of new axon growth, recent evidence shows that this is not true for the dopaminergic projection. In conclusion, the neurobiology of axons is likely to offer many new approaches to protective and restorative therapeutics. PMID:27003783
Le Maitre, Christine Lyn; Freemont, Anthony John; Hoyland, Judith Alison
2007-01-01
Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate. We hypothesised that this is due to accelerated cellular senescence, which causes fundamental changes in the ability of disc cells to maintain the intervertebral disc (IVD) matrix, thus leading to IVD degeneration. Cells isolated from non-degenerate and degenerate human tissue were assessed for mean telomere length, senescence-associated β-galactosidase (SA-β-gal), and replicative potential. Expression of P16INK4A (increased in cellular senescence) was also investigated in IVD tissue by means of immunohistochemistry. RNA from tissue and cultured cells was used for real-time polymerase chain reaction analysis for matrix metalloproteinase-13, ADAMTS 5 (a disintegrin and metalloprotease with thrombospondin motifs 5), and P16INK4A. Mean telomere length decreased with age in cells from non-degenerate tissue and also decreased with progressive stages of degeneration. In non-degenerate discs, there was an age-related increase in cellular expression of P16INK4A. Cells from degenerate discs (even from young patients) exhibited increased expression of P16INK4A, increased SA-β-gal staining, and a decrease in replicative potential. Importantly, there was a positive correlation between P16INK4A and matrix-degrading enzyme gene expression. Our findings indicate that disc cell senescence occurs in vivo and is accelerated in IVD degeneration. Furthermore, the senescent phenotype is associated with increased catabolism, implicating cellular senescence in the pathogenesis of IVD degeneration. PMID:17498290
Le Maitre, Christine Lyn; Freemont, Anthony John; Hoyland, Judith Alison
2007-01-01
Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear to occur at an accelerated rate. We hypothesised that this is due to accelerated cellular senescence, which causes fundamental changes in the ability of disc cells to maintain the intervertebral disc (IVD) matrix, thus leading to IVD degeneration. Cells isolated from non-degenerate and degenerate human tissue were assessed for mean telomere length, senescence-associated beta-galactosidase (SA-beta-gal), and replicative potential. Expression of P16INK4A (increased in cellular senescence) was also investigated in IVD tissue by means of immunohistochemistry. RNA from tissue and cultured cells was used for real-time polymerase chain reaction analysis for matrix metalloproteinase-13, ADAMTS 5 (a disintegrin and metalloprotease with thrombospondin motifs 5), and P16INK4A. Mean telomere length decreased with age in cells from non-degenerate tissue and also decreased with progressive stages of degeneration. In non-degenerate discs, there was an age-related increase in cellular expression of P16INK4A. Cells from degenerate discs (even from young patients) exhibited increased expression of P16INK4A, increased SA-beta-gal staining, and a decrease in replicative potential. Importantly, there was a positive correlation between P16INK4A and matrix-degrading enzyme gene expression. Our findings indicate that disc cell senescence occurs in vivo and is accelerated in IVD degeneration. Furthermore, the senescent phenotype is associated with increased catabolism, implicating cellular senescence in the pathogenesis of IVD degeneration. PMID:17498290
SARM1 activation triggers axon degeneration locally via NAD+ destruction
Gerdts, Josiah; Brace, E.J.; Sasaki, Yo; DiAntonio, Aaron
2015-01-01
Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown of NAD+ after injury. We used an engineered protease-sensitized SARM1 to demonstrate that SARM1 activity is required after axon injury to induce axon degeneration. Dimerization of the Toll-Interleukin Receptor (TIR) domain of SARM1 alone was sufficient to induce locally-mediated axon degeneration. Formation of the SARM1 TIR dimer triggered rapid breakdown of NAD+, whereas SARM1-induced axon destruction could be counteracted by increased NAD+ synthesis. SARM1-induced depletion of NAD+ may explain the potent axon protection in Wallerian Degeneration slow (Wlds) mutant mice. PMID:25908823
Anomalous skin effects in a weakly magnetized degenerate electron plasma
NASA Astrophysics Data System (ADS)
Abbas, G.; Sarfraz, M.; Shah, H. A.
2014-09-01
Fully relativistic analysis of anomalous skin effects for parallel propagating waves in a weakly magnetized degenerate electron plasma is presented and a graphical comparison is made with the results obtained using relativistic Maxwellian distribution function [G. Abbas, M. F. Bashir, and G. Murtaza, Phys. Plasmas 18, 102115 (2011)]. It is found that the penetration depth for R- and L-waves for degenerate case is qualitatively small in comparison with the Maxwellian plasma case. The quantitative reduction due to weak magnetic field in the skin depth in R-wave for degenerate plasma is large as compared to the non-degenerate one. By ignoring the ambient magnetic field, previous results for degenerate field free case are salvaged [A. F. Alexandrov, A. S. Bogdankevich, and A. A. Rukhadze, Principles of Plasma Electrodynamics (Springer-Verlag, Berlin/Heidelberg, 1984), p. 90].
Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice
Zhao, Yun-peng; Tian, Qing-yun; Liu, Ben; Cuellar, Jason; Richbourgh, Brendon; Jia, Tang-hong; Liu, Chuan-ju
2015-01-01
Intervertebral disc (IVD) degeneration is a common degenerative disease, yet much is unknown about the mechanisms during its pathogenesis. Herein we investigated whether progranulin (PGRN), a chondroprotective growth factor, is associated with IVD degeneration. PGRN was detectable in both human and murine IVD. The levels of PGRN were upregulated in murine IVD tissue during aging process. Loss of PGRN resulted in an early onset of degenerative changes in the IVD tissue and altered expressions of the degeneration-associated molecules in the mouse IVD tissue. Moreover, PGRN knockout mice exhibited accelerated IVD matrix degeneration, abnormal bone formation and exaggerated bone resorption in vertebra with aging. The acceleration of IVD degeneration observed in PGRN null mice was probably due to the enhanced activation of NF-κB signaling and β-catenin signaling. Taken together, PGRN may play a critical role in homeostasis of IVD, and may serve as a potential molecular target for prevention and treatment of disc degenerative diseases. PMID:25777988
Anomalous skin effects in a weakly magnetized degenerate electron plasma
Abbas, G. Sarfraz, M.; Shah, H. A.
2014-09-15
Fully relativistic analysis of anomalous skin effects for parallel propagating waves in a weakly magnetized degenerate electron plasma is presented and a graphical comparison is made with the results obtained using relativistic Maxwellian distribution function [G. Abbas, M. F. Bashir, and G. Murtaza, Phys. Plasmas 18, 102115 (2011)]. It is found that the penetration depth for R- and L-waves for degenerate case is qualitatively small in comparison with the Maxwellian plasma case. The quantitative reduction due to weak magnetic field in the skin depth in R-wave for degenerate plasma is large as compared to the non-degenerate one. By ignoring the ambient magnetic field, previous results for degenerate field free case are salvaged [A. F. Alexandrov, A. S. Bogdankevich, and A. A. Rukhadze, Principles of Plasma Electrodynamics (Springer-Verlag, Berlin/Heidelberg, 1984), p. 90].
Versal unfolding of planar Hamiltonian systems at fully degenerate equilibrium
NASA Astrophysics Data System (ADS)
Tang, Yilei; Zhang, Weinian
2016-07-01
In this paper we study bifurcations of a planar Hamiltonian system at a fully degenerate equilibrium, which has a zero linearization. Since the Poincaré normal form theory is not applicable to such a degenerate system, we investigate its restrictive normal forms in the class of Hamiltonian fields and prove that such a degenerate system is of codimension 3 degeneracy in the class, so that we introduce three parameters to versally unfold the degenerate system in the class. In order to discuss further the qualitative properties of the versal unfolding, we use the Poincaré index to determine the number and distribution of hyperbolic sectors near the degenerate equilibrium. We display its all bifurcations such as pitchfork bifurcation, saddle-center bifurcation and the Bogdanov-Takens bifurcation within Hamiltonian systems.
Global existence analysis for degenerate energy-transport models for semiconductors
NASA Astrophysics Data System (ADS)
Zamponi, Nicola; Jüngel, Ansgar
2015-04-01
A class of energy-transport equations without electric field under mixed Dirichlet-Neumann boundary conditions is analyzed. The system of degenerate and strongly coupled parabolic equations for the particle density and temperature arises in semiconductor device theory. The global-in-time existence of weak nonnegative solutions is shown. The proof consists of a variable transformation and a semi-discretization in time such that the discretized system becomes elliptic and semilinear. Positive approximate solutions are obtained by Stampacchia truncation arguments and a new cut-off test function. Nonlogarithmic entropy inequalities yield gradient estimates which allow for the limit of vanishing time step sizes. Exploiting the entropy inequality, the long-time convergence of the weak solutions to the constant steady state is proved. Because of the lack of appropriate convex Sobolev inequalities to estimate the entropy dissipation, only an algebraic decay rate is obtained. Numerical experiments indicate that the decay rate is typically exponential.
Cylindrical and Spherical Ion-Acoustic Shock Waves in a Relativistic Degenerate Multi-Ion Plasma
NASA Astrophysics Data System (ADS)
Hossen, M. R.; Nahar, L.; Mamun, A. A.
2014-12-01
A rigorous theoretical investigation has been made to study the existence and basic features of the ion-acoustic (IA) shock structures in an unmagnetized, collisionless multi-ion plasma system (containing degenerate electron fluids, inertial positively as well as negatively charged ions, and arbitrarily charged static heavy ions). This investigation is valid for both non-relativistic and ultra-relativistic limits. The reductive perturbation technique has been employed to derive the modified Burgers equation. The solution of this equation has been numerically examined to study the basic properties of shock structures. The basic features (speed, amplitude, width, etc.) of these electrostatic shock structures have been briefly discussed. The basic properties of the IA shock waves are found to be significantly modified by the effects of arbitrarily charged static heavy ions and the plasma particle number densities. The implications of our results in space and interstellar compact objects like white dwarfs, neutron stars, black holes, and so on have been briefly discussed.
Strongly magnetized cold electron degenerate gas: Mass-radius relation of the collapsed star
NASA Astrophysics Data System (ADS)
Das, Upasana; Mukhopadhyay, Banibrata
2012-07-01
We consider a relativistic, degenerate electron gas at zero-temperature under the influence of a strong, uniform, static magnetic field, neglecting any form of interactions. Since the density of states for the electrons changes due to the presence of the magnetic field (which gives rise to Landau quantization), the corresponding equation of state also gets modified. In order to investigate the effect of very strong magnetic field, we focus only on systems in which a maximum of either one, two or three Landau level(s) is/are occupied. This is important since, if a very large number of Landau levels are filled, it implies a very low magnetic field strength which yields back Chandrasekhar's celebrated non-magnetic results. The maximum number of Landau levels occupied is fixed by the correct choice of two parameters, namely the magnetic field strength and the maximum Fermi energy of the system. We study the equations of state of these one-level, two-level and three-level systems and compare them by taking three different maximum Fermi energies. We also find the effect of the strong magnetic field on the mass-radius relation of the underlying star composed of the gas stated above. We obtain an interesting theoretical result that, it is possible to have an electron degenerate static star with a mass significantly greater than the Chandrasekhar limit, provided it has an appropriate magnetic field strength and central density.
Shore, B.W.
1981-01-30
The equations of motion are discussed which describe time dependent population flows in an N-level system, reviewing the relationship between incoherent (rate) equations, coherent (Schrodinger) equations, and more general partially coherent (Bloch) equations. Approximations are discussed which replace the elaborate Bloch equations by simpler rate equations whose coefficients incorporate long-time consequences of coherence.
Widespread cytoskeletal pathology characterizes corticobasal degeneration.
Feany, M. B.; Dickson, D. W.
1995-01-01
Corticobasal degeneration (CBD) is a rare, progressive neurological disorder characterized by widespread neuronal and glial pathology. Using immunohistochemistry and laser confocal microscopy, we demonstrate that the nonamyloid cortical plaques of CBD are actually collections of abnormal tau in the distal processes of astrocytes. These glial cells express both vimentin and CD44, markers of astrocyte activation. Glial pathology also includes tau-positive cytoplasmic inclusions, here localized to Leu 7-expressing oligodendrocytes. In addition, a wide array of neuronal pathology is defined with tau-positive inclusions in multiple domains of a variety of cortical neurons. CBD thus exhibits widespread glial and neuronal cytoskeletal pathology, including a novel structure, the astrocytic plaque. CBD is a disease of generalized cytoskeletal disruption affecting several cell types and multiple domains of these cells. The further definition of CBD pathology refines the diagnosis and pathophysiological understanding of this unique disease and has important implications for other neurodegenerative diseases, like Alzheimer's disease, characterized by abnormal tau deposition. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:7778678
CERKL Knockdown Causes Retinal Degeneration in Zebrafish
Riera, Marina; Burguera, Demian; Garcia-Fernàndez, Jordi; Gonzàlez-Duarte, Roser
2013-01-01
The human CERKL gene is responsible for common and severe forms of retinal dystrophies. Despite intense in vitro studies at the molecular and cellular level and in vivo analyses of the retina of murine knockout models, CERKL function remains unknown. In this study, we aimed to approach the developmental and functional features of cerkl in Danio rerio within an Evo-Devo framework. We show that gene expression increases from early developmental stages until the formation of the retina in the optic cup. Unlike the high mRNA-CERKL isoform multiplicity shown in mammals, the moderate transcriptional complexity in fish facilitates phenotypic studies derived from gene silencing. Moreover, of relevance to pathogenicity, teleost CERKL shares the two main human protein isoforms. Morpholino injection has been used to generate a cerkl knockdown zebrafish model. The morphant phenotype results in abnormal eye development with lamination defects, failure to develop photoreceptor outer segments, increased apoptosis of retinal cells and small eyes. Our data support that zebrafish Cerkl does not interfere with proliferation and neural differentiation during early developmental stages but is relevant for survival and protection of the retinal tissue. Overall, we propose that this zebrafish model is a powerful tool to unveil CERKL contribution to human retinal degeneration. PMID:23671706
Statistical physics of age related macular degeneration
NASA Astrophysics Data System (ADS)
Family, Fereydoon; Mazzitello, K. I.; Arizmendi, C. M.; Grossniklaus, H. E.
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). The RPE is a phagocytic system that is essential for renewal of photoreceptors (rods and cones). With time, incompletely degraded membrane material builds up in the form of lipofuscin. Lipofuscin is made of free-radical-damaged protein and fat, which forms not only in AMD, but also Alzheimer disease and Parkinson disease. The study of lipofuscin formation and growth is important, because of their association with cellular aging. We introduce a model of non-equilibrium cluster growth and aggregation that we have developed for studying the formation and growth of lipofuscin in the aging RPE. Our results agree with a linear growth of the number of lipofuscin granules with age. We apply the dynamic scaling approach to our model and find excellent data collapse for the cluster size distribution. An unusual feature of our model is that while small particles are removed from the RPE the larger ones become fixed and grow by aggregation.
Physics of Age Related Macular Degeneration
NASA Astrophysics Data System (ADS)
Family, Fereydoon
2009-11-01
Age-related macular degeneration (AMD) is the leading cause of blindness beyond the age of 50 years. The most common pathogenic mechanism that leads to AMD is choroidal neovascularization (CNV). CNV is produced by accumulation of residual material caused by aging of retinal pigment epithelium cells (RPE). The RPE is a phagocytic system that is essential for renewal of photoreceptors (rods and cones). With time, incompletely degraded membrane material builds up in the form of lipofuscin. Lipofuscin is made of free-radical-damaged protein and fat, which forms not only in AMD, but also Alzheimer's disease, and Parkinson's disease. The study of lipofuscin formation and growth is important, because of their association with cellular aging. In this talk I will discuss a model of non-equilibrium cluster growth that we have developed for studying the formation and growth of lipofuscin in AMD [K.I. Mazzitello, C.M. Arizmendi, Fereydoon Family, H. E. Grossniklaus, Physical Review E (2009)]. I will also present an overview of our theoretical and computational efforts in modeling some other aspects of the physics of AMD, including CNV and the breakdown of Bruch's membrane [Ongoing collaboration with Abbas Shirinifard and James A. Glazier, Biocomplexity Institute and Department of Physics, Indiana University, Y. Jiang, Los Alamos, and Hans E. Grossniklaus, Department of Ophthalmology, Emory University].
[Multiple system atrophy - synuclein and neuronal degeneration].
Yoshida, Mari
2011-11-01
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that encompasses olivopontocerebellar atrophy (OPCA), striatonigral degeneration (SND) and Shy-Drager syndrome (SDS). The histopathological hallmarks are α-synuclein (AS) positive glial cytoplasmic inclusions (GCIs) in oligodendroglias. AS aggregation is also found in glial nuclear inclusions (GNIs), neuronal cytoplasmic inclusions (NCIs), neuronal nuclear inclusions (NNIs) and dystrophic neurties. Reviewing the pathological features of 102 MSA cases, OPCA-type was relatively more frequent and SND-type was less frequent in Japanese MSA cases, which suggested different phenotypic pattern of MSA might exist between races, compared to the relatively high frequency of SND-type in western countries. In early stage of MSA, NNIs, NCIs and diffuse homogenous stain of AS in neuronal nuclei and cytoplasm were observed in various vulnerable lesions including the pontine nuclei, putamen, substantia nigra, locus ceruleus, inferior olivary nucleus, intermediolateral column of thoracic cord, lower motor neurons and cortical pyramidal neurons, in additions to GCIs. These findings indicated that the primary nonfibrillar and fibrillar AS aggregation also occurred in neurons. Therefore both the direct involvement of neurons themselves and the oligodendroglia-myelin-axon mechanism may synergistically accelerate the degenerative process of MSA. PMID:22277386
Disruption in dopaminergic innervation during photoreceptor degeneration.
Ivanova, Elena; Yee, Christopher W; Sagdullaev, Botir T
2016-04-15
Dopaminergic amacrine cells (DACs) release dopamine in response to light-driven synaptic inputs, and are critical to retinal light adaptation. Retinal degeneration (RD) compromises the light responsiveness of the retina and, subsequently, dopamine metabolism is impaired. As RD progresses, retinal neurons exhibit aberrant activity, driven by AII amacrine cells, a primary target of the retinal dopaminergic network. Surprisingly, DACs are an exception to this physiological change; DACs exhibit rhythmic activity in healthy retina, but do not burst in RD. The underlying mechanism of this divergent behavior is not known. It is also unclear whether RD leads to structural changes in DACs, impairing functional regulation of AII amacrine cells. Here we examine the anatomical details of DACs in three mouse models of human RD to determine how changes to the dopaminergic network may underlie physiological changes in RD. By using rd10, rd1, and rd1/C57 mice we were able to dissect the impacts of genetic background and the degenerative process on DAC structure in RD retina. We found that DACs density, soma size, and primary dendrite length are all significantly reduced. Using a novel adeno-associated virus-mediated technique to label AII amacrine cells in mouse retina, we observed diminished dopaminergic contacts to AII amacrine cells in RD mice. This was accompanied by changes to the components responsible for dopamine synthesis and release. Together, these data suggest that structural alterations of the retinal dopaminergic network underlie physiological changes during RD. PMID:26356010
[Criteria for the diagnosis of corticobasal degeneration].
Shimohata, Takayoshi; Aiba, Ikuko; Nishizawa, Masatoyo
2015-04-01
Corticobasal degeneration (CBD) is a distinct neurodegenerative disorder characterized by widespread neuronal and glial accumulation of abnormally phosphorylated tau protein. Patients with CBD often present with corticobasal syndrome (CBS) showing impairment of the motor system, cognition, or both. Several studies demonstrate that they may also present with progressive supranuclear palsy syndrome (PSPS), aphasia, Alzheimer disease-like dementia, or behavioral changes, suggesting that CBS is merely one of the presenting phenotypes of CBD. Accurate diagnosis is important for future clinical trials using drugs aimed at modifying the underlying tau pathology. Although previous CBD diagnostic criteria reflected only CBS, Armstrong et al. proposed new diagnostic criteria for CBD in 2013 (Armstrong's criteria). The new criteria include 4 CBD phenotypes, including CBS, frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and PSPS. These phenotypes were combined to create 2 sets of criteria: specific clinical research criteria for probable CBD (cr-CBD) and broader criteria for possible CBD that are more inclusive but have a higher probability of detecting other tau-based pathologies (p-CBD). However, two recent studies revealed that the sensitivity and specificity of these criteria were insufficient. Further refinement of the criteria is needed via biomarker research with prospective study designs. (Received August 19, 2014; Accepted December 26, 2014: Published April 1, 2015). PMID:25846600
Diagnoses of corticobasal syndrome and corticobasal degeneration.
Shimohata, Takayoshi; Aiba, Ikuko; Nishizawa, Masatoyo
2016-03-30
Experts use the term corticobasal syndrome (CBS) for patients with a clinical diagnosis of corticobasal degeneration (CBD), and reserve CBD for those whose conditions have been diagnosed on the basis of neuropathological analyses. Several studies demonstrated that patients with CBD may also present with progressive supranuclear syndrome (PSPS), aphasia, Alzheimer disease-like dementia or behavioral change, suggesting that CBS is merely one of the presenting phenotypes of CBD. Although previous CBD diagnostic criteria reflected only CBS, the international consortium proposed new diagnostic criteria for CBD in 2013 (Armstrong's criteria). The new criteria include 4 CBD subtypes; CBS, frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA)，and PSPS. These subtypes were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD (cr-CBD) and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies (p-CBD). Two studies have already revealed that the sensitivity and specificity of the criteria were not high. Because therapeutic interventions that target abnormally-phosphorylated tau have started, further refinement of the criteria is needed via biomarker researches with prospective study designs. PMID:26876110
Age-related macular degeneration: choroidal ischaemia?
Coleman, D Jackson; Silverman, Ronald H; Rondeau, Mark J; Lloyd, Harriet O; Khanifar, Aziz A; Chan, R V Paul
2013-01-01
Aim Our aim is to use ultrasound to non-invasively detect differences in choroidal microarchitecture possibly related to ischaemia among normal eyes and those with wet and dry age-related macular degeneration (AMD). Design Prospective case series of subjects with dry AMD, wet AMD and age-matched controls. Methods Digitised 20 MHz B-scan radiofrequency ultrasound data of the region of the macula were segmented to extract the signal from the retina and choroid. This signal was processed by a wavelet transform, and statistical modelling was applied to the wavelet coefficients to examine differences among dry, wet and non-AMD eyes. Receiver operating characteristic (ROC) analysis was used to evaluate a multivariate classifier. Results In the 69 eyes of 52 patients, 18 did not have AMD, 23 had dry AMD and 28 had wet AMD. Multivariate models showed statistically significant differences between groups. Multiclass ROC analysis of the best model showed an excellent volume-under-curve of 0.892±0.17. The classifier is consistent with ischaemia in dry AMD. Conclusions Wavelet augmented ultrasound is sensitive to the organisational elements of choroidal microarchitecture relating to scatter and fluid tissue boundaries such as seen in ischaemia and inflammation, allowing statistically significant differentiation of dry, wet and non-AMD eyes. This study further supports the association of ischaemia with dry AMD and provides a rationale for treating dry AMD with pharmacological agents to increase choroidal perfusion. ClinicalTrials.gov registration NCT00277784. PMID:23740965
Animal models of age related macular degeneration
Pennesi, Mark E.; Neuringer, Martha; Courtney, Robert J.
2013-01-01
Age related macular degeneration (AMD) is the leading cause of vision loss of those over the age of 65 in the industrialized world. The prevalence and need to develop effective treatments for AMD has lead to the development of multiple animal models. AMD is a complex and heterogeneous disease that involves the interaction of both genetic and environmental factors with the unique anatomy of the human macula. Models in mice, rats, rabbits, pigs and non-human primates have recreated many of the histological features of AMD and provided much insight into the underlying pathological mechanisms of this disease. In spite of the large number of models developed, no one model yet recapitulates all of the features of human AMD. However, these models have helped reveal the roles of chronic oxidative damage, inflammation and immune dysregulation, and lipid metabolism in the development of AMD. Models for induced choroidal neovascularization have served as the backbone for testing new therapies. This article will review the diversity of animal models that exist for AMD as well as their strengths and limitations. PMID:22705444
An Interferometric Harvest of Double Degenerates
NASA Astrophysics Data System (ADS)
Nelan, Edmund
2001-07-01
The white dwarf {WD} mass and age distributions hold clues to the star formation history of our Galaxy and the age of the disk. To extract this information we need to carefully calibrate the WD mass-radius relation and the WD cooling curve. But to do so, we must directly determine the masses for a variety of WDs of different sub-types. The only direct method is through the orbital analysis of resolved WDs in non- interacting binary systems. Sadly, this has been done, with varying quality, for only 4 WDs {40 Eri B, Sirius B, Procyon B, and Stien 2051B}, mainly because it is extremely difficult to resolve WDs in binary systems with periods less than 50 years. We propose a high angular resolution Snapshot survey with FGS1r to observe cool WDs with the objective of discovering {resolving} double degenerate systems with modest separations and periods as short as 25 years, ideal binaries for follow up mass determinations. By carefully selecting our targets, about 10 such systems should be revealed. This will dramatically increase the number of WDs available for dynamical mass measurements {its 2 for 1.}, enabling a better calibration the WD mass-radius relation.
Kreisler, A; Mastain, B; Tison, F; Fénelon, G; Destée, A
2007-12-01
We report on five patients with a clinical presentation of corticobasal degeneration (CBD), including gradually progressive, asymmetric, L-DOPA-resistant parkinsonism associated variously with apraxia, focal action myoclonus, focal dystonia, cortical sensory loss and alien limb phenomenon. Some patients also presented an atypical CBD clinical history or signs - notably sudden onset. The disease was however not suggestive of another diagnosis. Magnetic resonance imaging of the brain revealed extensive vascular lesions. Only five similar cases have been published to our knowledge. Although we cannot exclude underlying CBD pathology, our cases illustrate the fact that multi-infarct pathology can masquerade as CBD or alter the clinical phenotype of the disease. PMID:18355466
NASA Astrophysics Data System (ADS)
Akbari-Moghanjoughi, M.
2012-06-01
More recently, Roy et al. [Phys. Plasmas 19, 033705 (2012)] have investigated the occurrence of nonlinear solitary and double-layers in an ultrarelativistic dusty electron-positron-ion degenerate plasma using a Sagdeev potential method. They have considered a full parametric examination on Mach-number criteria for existence of such nonlinear excitations using the specific degeneracy limits of Chandrasekhar equation of state (EoS) for Fermi-Dirac plasmas. In this comment, we point-out a misleading extension of polytropic EoS to study the Fermi-Dirac relativistically degenerate plasmas.
Akbari-Moghanjoughi, M.
2012-06-15
More recently, Roy et al.[Phys. Plasmas 19, 033705 (2012)] have investigated the occurrence of nonlinear solitary and double-layers in an ultrarelativistic dusty electron-positron-ion degenerate plasma using a Sagdeev potential method. They have considered a full parametric examination on Mach-number criteria for existence of such nonlinear excitations using the specific degeneracy limits of Chandrasekhar equation of state (EoS) for Fermi-Dirac plasmas. In this comment, we point-out a misleading extension of polytropic EoS to study the Fermi-Dirac relativistically degenerate plasmas.
Delivery systems for the treatment of degenerated intervertebral discs.
Blanquer, S B G; Grijpma, D W; Poot, A A
2015-04-01
The intervertebral disc (IVD) is the most avascular and acellular tissue in the body and therefore prone to degeneration. During IVD degeneration, the balance between anabolic and catabolic processes in the disc is deregulated, amongst others leading to alteration of extracellular matrix production, abnormal enzyme activities and production of pro-inflammatory substances like cytokines. The established treatment strategy for IVD degeneration consists of physiotherapy, pain medication by drug therapy and if necessary surgery. This approach, however, has shown limited success. Alternative strategies to increase and prolong the effects of bioactive agents and to reverse the process of IVD degeneration include the use of delivery systems for drugs, proteins, cells and genes. In view of the specific anatomy and physiology of the IVD and depending on the strategy of the therapy, different delivery systems have been developed which are reviewed in this article. PMID:25451138
Degenerate higher derivative theories beyond Horndeski: evading the Ostrogradski instability
NASA Astrophysics Data System (ADS)
Langlois, David; Noui, Karim
2016-02-01
Theories with higher order time derivatives generically suffer from ghost-like instabilities, known as Ostrogradski instabilities. This fate can be avoided by considering ``degenerate'' Lagrangians, whose kinetic matrix cannot be inverted, thus leading to constraints between canonical variables and a reduced number of physical degrees of freedom. In this work, we derive in a systematic way the degeneracy conditions for scalar-tensor theories that depend quadratically on second order derivatives of a scalar field. We thus obtain a classification of all degenerate theories within this class of scalar-tensor theories. The quartic Horndeski Lagrangian and its extension beyond Horndeski belong to these degenerate cases. We also identify new families of scalar-tensor theories with the property that they are degenerate despite the nondegeneracy of the purely scalar part of their Lagrangian.
Construction of nonregular pointwise degenerate delay-differential systems
NASA Technical Reports Server (NTRS)
Choudhury, A. K.
1978-01-01
Pointwise degenerate delay-differential systems (degeneracy at t = 2h) are reduced to Popov's construction under the regularity assumption. Necessary and sufficient conditions for the degeneracy are outlined.
Degenerations of generalized Krichever-Novikov algebras on tori
NASA Astrophysics Data System (ADS)
Schlichenmaier, Martin
1993-08-01
Degenerations of Lie algebras of meromorphic vector fields on elliptic curves (i.e., complex tori) which are holomorphic outside a certain set of points (markings) are studied. By an algebraic geometric degeneration process certain subalgebras of Lie algebras of meromorphic vector fields on P1, the Riemann sphere, are obtained. In case of some natural choices of the markings these subalgebras are explicitly determined. It is shown that the number of markings can change.
Single-degenerate Type Ia Supernovae Are Preferentially Overluminous
NASA Astrophysics Data System (ADS)
Fisher, Robert; Jumper, Kevin
2015-06-01
Recent observational and theoretical progress has favored merging and helium-accreting sub-Chandrasekhar mass white dwarfs (WDs) in the double-degenerate and the double-detonation channels, respectively, as the most promising progenitors of normal Type Ia supernovae (SNe Ia). Thus the fate of rapidly accreting Chandrasekhar mass WDs in the single-degenerate channel remains more mysterious then ever. In this paper, we clarify the nature of ignition in Chandrasekhar-mass single-degenerate SNe Ia by analytically deriving the existence of a characteristic length scale which establishes a transition from central ignitions to buoyancy-driven ignitions. Using this criterion, combined with data from three-dimensional simulations of convection and ignition, we demonstrate that the overwhelming majority of ignition events within Chandrasekhar-mass WDs in the single-degenerate channel are buoyancy-driven, and consequently lack a vigorous deflagration phase. We thus infer that single-degenerate SNe Ia are generally expected to lead to overluminous 1991T-like SNe Ia events. We establish that the rates predicted from both the population of supersoft X-ray sources (SSSs) and binary population synthesis models of the single-degenerate channel are broadly consistent with the observed rates of overluminous SNe Ia, and suggest that the population of SSSs are the dominant stellar progenitors of SNe 1991T-like events. We further demonstrate that the single-degenerate channel contribution to the normal and failed 2002cx-like rates is not likely to exceed 1% of the total SNe Ia rate. We conclude with a range of observational tests of overluminous SNe Ia which will either support or strongly constrain the single-degenerate scenario.
Simulation of biological therapies for degenerated intervertebral discs.
Zhu, Qiaoqiao; Gao, Xin; Temple, H Thomas; Brown, Mark D; Gu, Weiyong
2016-04-01
The efficacy of biological therapies on intervertebral disc repair was quantitatively studied using a three-dimensional finite element model based on a cell-activity coupled multiphasic mixture theory. In this model, cell metabolism and matrix synthesis and degradation were considered. Three types of biological therapies-increasing the cell density (Case I), increasing the glycosaminoglycan (GAG) synthesis rate (Case II), and decreasing the GAG degradation rate (Case III)-to the nucleus pulposus (NP) of each of two degenerated discs [one mildly degenerated (e.g., 80% viable cells in the NP) and one severely degenerated (e.g., 30% viable cells in the NP)] were simulated. Degenerated discs without treatment were also simulated as a control. The cell number needed, nutrition level demanded, time required for the repair, and the long-term outcomes of these therapies were analyzed. For Case I, the repair process was predicted to be dependent on the cell density implanted and the nutrition level at disc boundaries. With sufficient nutrition supply, this method was predicted to be effective for treating both mildly and severely degenerated discs. For Case II, the therapy was predicted to be effective for repairing the mildly degenerated disc, but not for the severely degenerated disc. Similar results were predicted for Case III. No change in cell density for Cases II and III were predicted under normal nutrition level. This study provides a quantitative guide for choosing proper strategies of biological therapies for different degenerated discs. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:699-708, 2016. PMID:26425965