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Toxicity in goats caused by oleander ( Nerium oleander)  

Microsoft Academic Search

Cases of poisoning by oleander (Nerium oleander) were observed in several species, except in goats. This study aimed to evaluate the pathological effects of oleander in goats. The experimental design used three goats per group: the control group, which did not receive oleander and the experimental group, which received leaves of oleander (50mg\\/kg\\/day) for six consecutive days. On the seventh

R. R. Barbosa; J. D. Fontenele-Neto; B. Soto-Blanco



Acute cattle intoxication from Nerium oleander pods  

Microsoft Academic Search

Seven outbreaks of acute intoxication from oleander (Nerium oleander) in cattle were reported in Northeast of Brazil. A total of 92 cattle were poisoned by oleander in 7 different herds; 57\\u000a animals died (67% of affected cattle). All cases reported here occurred during dry season. Two of the outbreaks resulted from\\u000a offering oleander triturated and mixed with fodder. In the

B. Soto-Blanco; J. D. Fontenele-Neto; D. M. Silva; P. F. C. C. Reis; J. E. Nóbrega



Attività cambiale in Nerium oleander L. a Genova  

Microsoft Academic Search

The cambial activity in Nerium oleander L. in Genoa. – The cambial activity in Nerium oleander L. is observed in order to compare the increasing rhythm of a specimen cultivated in Genoa with the rhythm of spontaneous and cultivated specimens growing in Puglia and Lucania, previously studied by other authors.In Genoa Nerium oleander, a strongly scleromorphus species, has a nearly

Paola Gastaldo; Paola Profumo



Osservazioni Sull'attività Cambiale Di Nerium Oleander L  

Microsoft Academic Search

Observation on the cambial activity in «Nerium oleander» L. — The cambial activity of «Nerium oleander» has been observed in three localities in Southern Italy: Bari and Lucera, where the oleander is cultivated, and Policoro, in the bed of the river Sinni, where the oleander is spontaneuos. The wood is of the diffuse-porous type. Growth rings corresponding to distinct periods

Olimpia Bucci



Two cytotoxic pentacyclic triterpenoids from Nerium oleander  

Microsoft Academic Search

The isolation and structure elucidation of two novel cytotoxic pentacyclic triterpenoids cis-karenin (3?-hydroxy-28-Z-p-coumaroyloxy-urs-12-en-27-oic acid) and trans-karenin (3-?-hydroxy-28-E-p-coumaroyloxy-urs-12-en-27-oic acid) from the leaves of Nerium oleander is described.

Bina Shaheen Siddiqui; Sabira Begum; Salimuzzaman Siddiqui; Wolf Lichter



Toxicity in goats caused by oleander (Nerium oleander).  


Cases of poisoning by oleander (Nerium oleander) were observed in several species, except in goats. This study aimed to evaluate the pathological effects of oleander in goats. The experimental design used three goats per group: the control group, which did not receive oleander and the experimental group, which received leaves of oleander (50 mg/kg/day) for six consecutive days. On the seventh day, goats received 110 mg/kg of oleander leaves four times at one-hourly interval. A last dose of 330 mg/kg of oleander leaves was given subsequently. After the last dose was administered, clinical signs such as apathy, colic, vocalizations, hyperpnea, polyuria, and moderate rumen distention were observed. Electrocardiogram revealed second-degree atrioventricular block. Death occurred on an average at 92 min after the last dosing. Microscopic evaluation revealed renal necrosis at convoluted and collector tubules and slight myocardial degeneration was observed by unequal staining of cardiomyocytes. Data suggest that goats appear to respond to oleander poisoning in a manner similar to other species. PMID:18031775

Barbosa, R R; Fontenele-Neto, J D; Soto-Blanco, B



Triterpenoids from the leaves of Nerium oleander  

Microsoft Academic Search

Two new triterpenoids have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3?,27-dihydroxy-urs-18-en-13,28-olide and 3?,22?,28-trihydroxy-25-nor-lup-1 (10),20(29)-dien-2-one. Elucidation of the structures was based on spectroscopic methods including one-dimensional and two-dimensional NMR (COSY-45, NOESY and J-resolved).

Sabira Begum; Razia Sultana; Bina S. Siddiqui



[Chemical burns caused by the shrub nerium oleander].  


Nerium Oleander is a shrub that grows naturally in the Mediterranean regions. In Morocco it is found in wet places. It is famous for its risk of systemic toxicity in cases of poisoning because of the presence of two alkaloids, especially oleandrine. The literature describes cases of local use of leaves of this plant against scabies, haemorrhoids, and boils. We report two cases of chemical burns of different gravity due to Nerium Oleander. This should lead to more widely diffused information for the general population and strict regulation of its marketing. PMID:21991211

Bakkali, H; Ababou, M; Nassim Sabah, T; Moussaoui, A; Ennouhi, A; Fouadi, F Z; Siah, S; Ihrai, H



Bioactive cardenolides from the leaves of Nerium oleander  

Microsoft Academic Search

A bioactivity directed isolation of the methanolic extract of the fresh, uncrushed leaves of Nerium oleander showing a central nervous system (CNS) depressant effect in mice has been undertaken. As a result, four CNS depressant cardenolides including a new cardenolide, neridiginoside and three known constituents, nerizoside, neritaloside and odoroside-H, have been isolated which exhibited CNS depressant activity in mice at

Sabira Begum; Bina S Siddiqui; Razia Sultana; Atiya Zia; Amin Suria



Clinical and Pathological Aspects of Experimental Oleander ( Nerium oleander ) Toxicosis in Sheep  

Microsoft Academic Search

Dried Nerium oleander leaves at single lethal dose of 110 mg\\/kg body weight were administered orally to six native male sheep.\\u000a Clinical signs of toxicosis in sheep began to appear about 30 min after receiving the oleander and included decrease of the\\u000a heart rate followed by cardiac pauses and tachyarrhythmias; ruminal atony, mild to moderate tympany, abdominal pain, polyuria\\u000a and

M. R. Aslani; A. R. Movassaghi; M. Mohri; A. Abbasian; M. Zarehpour



Somatic embryogenesis and plant regeneration of Nerium oleander  

Microsoft Academic Search

Leaf explants of Nerium oleander L. produced masses of callus when both an auxin and a cytokinin were included in the medium. Leaves cultured on the B5 medium of Gamborg et al. supplemented with 2,4-dichlorophenoxyacetic acid (2,4-d; 9.05 µM) plus benzyladenine (BA; 4.4 µM) produced callus and profuse rhizogenesis was observed from callus developed from older leaves. On Murashige &

Isabel Santos; Isabel Guimarães; Roberto Salema



Experimental oleander (Nerium oleander) intoxication in broiler chickens (Gallus gallus).  


Dried leaves of oleander were orally given at a single dose of 500 mg/kg body weight to 20 clinically healthy male chickens. Clinical signs of toxicosis began to appear about 1 h after receiving the oleander and included hypersalivation, vomiting, diarrhea, deep depression, and sudden death. Also, hyperemia in the combs and wattles was obviously seen. Electrocardiograms (ECG) were repeatedly recorded at 30 min intervals. ECGs findings included increasing the QRS duration in some birds and various kinds of arrhythmias. Bradycardia was the most frequently detected finding (30.43%). During necropsy, there were congestion and hemorrhages in the visceral organs particularly in heart, liver, kidney, and lung. Histopathology revealed myocardial cell necrosis with hyperemia and hemorrhage, severe diffuse pulmonary congestion and edema, severe renal congestion and hemorrhage with tubular necrosis, and coagulative necrosis of hepatocytes with hyperemia and hemorrhage. There were also congestion, mild epithelial necrosis and desquamation with infiltration of mononuclear inflammatory cells in the proventriculus of all birds. There was also mild to moderate congestion in the intestines with scattered necrosis of surface enterocytes. The lack of information about the toxicity of oleanders in poultry was the main cause for this study. The results suggest that chickens appear to respond to oleander poisoning in a manner similar to other species. PMID:21576188

Omidi, Arash; Razavizadeh, Alireza T; Movassaghi, Ahmad R; Aslani, Mohammad R



Two new triterpenoid isomers from Nerium oleander leaves.  


Two new triterpenoid isomers alpha-neriursate (1) and beta-neriursate (2) have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3alpha-acetophenoxy-urs-12-en-28-oic acid and 3beta-acetophenoxy-urs-12-en-28-oic acid, respectively. The structure elucidation is based on spectroscopic methods, including 1D ((1)H NMR, (13)C NMR) and 2D ((1)H-(1)H COSY, NOESY, HMQC, HMBC and J-resolved) NMR data and chemical transformation. PMID:19851926

Siddiqui, Bina S; Khatoon, Nasima; Begum, Sabira; Durrani, Saima A



A novel antibacterial and cardiac steroid from the roots of Nerium oleander  

Microsoft Academic Search

The roots of Nerium oleander yielded a new cardenolide, 12?-hydroxy-5?-carda-8,14,16,20(22)-tetraenolide (2). Biological screening of the compound revealed antibacterial and digoxin-like cardiac activities.

M. Mostaqul Huq; A Jabbar; M. A Rashid; C. M Hasan



Nerium oleander L. as a biomonitor of lead and other heavy metal pollution in Mediterranean environments  

Microsoft Academic Search

The leaves of Nerium oleander L. (oleander) were tested as a possible biomonitor of heavy metal pollution studied in Antalya along the Mediterranean Sea, Turkey. Fifty-three sites (urban roadside, urban, urban park, suburban andrural) in and around Antalya city were investigated. The concentration of Pb, Cd, Zn and Cu were determined in unwashed and washed leaves and soils. Differences between

A. Aksoy; M. A. Öztürk



Free Radical Scavenging Potential and Reducing Capacity of Flowers of Nerium oleander Linn  

Microsoft Academic Search

Nerium oleander (Apocynaceae) is a drought-tolerant evergreen free-flowering shrub that has been used in Chinese folk medicine. The present study evaluated the free radical-scavenging activity of the extracts of N. oleander flowers in aqueous, n.hexane, petroleum ether, ethylacetate, and ethanol using in vitro assays of 1,1-diphenyl-1-picrylhydrazyl radical-scavenging assay, lipid peroxidation inhibition assay, nitric oxide radical-scavenging assay, and reducing potential. Further,

V. Gayathri; S. Ananthi; R. P. Parameswari; Hannah R. Vasanthi



Cardioprotective Effect of Nerium oleander Flower Against Isoproterenol-Induced Myocardial Oxidative Stress in Experimental Rats  

Microsoft Academic Search

Nerium oleander Linn (NOL) an evergreen shrub belonging to the Apocynaceae family has been reported to have a wide spectrum of bioactivities. In in vitro study, the free radical scavenging potential of the hydroethanolic extract of N oleander Linn (ENO) flower and its fractions (glycosidic and nonglycosidic) were studied using 2, 2'-azino-di [3-ethylbenzthiazoline sulphonate] (ABTS*+ ) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH*)

Veeraraghavan Gayathri; Subhash Ananthi; Chandranayagam Chandronitha; Ganapathy Ramakrishnan; Raman Lakshmi Sundaram; Hannah R. Vasanthi



[A non-fatal Nerium oleander self-poisoning: case report and discussion].  


Nerium oleander is potentially lethal plants after ingestion. We report a case of poisoning by these plants. Our patient complained of nausea, vomiting, and diarrhoea. He had bradycardia during first twelve hours. He was discharge after 3 days. All parts of these plants are toxic and contain a variety of cardiac glycosides including oleandrin. In most cases, clinical management of poisoning by N. oleander involves administration of activated charcoal and supportive care. Digoxin specific Fab fragments are an effective treatment. PMID:21890104

Hugues, T; Arnoult, M; Beau, N; Yaici, K; Mélandri, P; Saoudi, N; Gibelin, P



Three new cardenolides from methanol extract of stems and twigs of Nerium oleander.  


Two new cardenolide monoglycosides, cardenolides B-1 (1) and B-2 (2) were isolated from Nerium oleander, together with oleagenin (3) which is the first isolated compound from natural sources. The structure of compounds 1-3 were established on the basis of their spectroscopic data. PMID:20686265

Bai, Liming; Zhao, Ming; Toki, Asami; Sakai, Jun-ichi; Yang, Xiao-yang; Bai, Yuhua; Ando, Mariko; Hirose, Katsutoshi; Ando, Masayoshi



Synchrotron radiation X-ray fluorescence analysis of trace elements in Nerium oleander for pollution monitoring  

Microsoft Academic Search

This works describes the use of synchrotron radiation fluorescence analysis as a technique for monitoring trace elements in bio-indicators for environmental pollution control. The analyses were performed on leaves of Nerium oleander collected in streets with different levels of traffic flow in Rio de Janeiro, Brazil, with one sample from a rural zone. The leaves were collected from adult trees

E. F. O. de Jesus; S. M. Simabuco; M. J. dos Anjos; R. T. Lopes



Cytochemical localization of pectinase activity in laticifers of Nerium oleander L  

Microsoft Academic Search

Summary A method is described for the cytochemical localization of pectinase activity at the ultrastructural level. The procedure involves the use of Benedict's reagent to form an electron-dense copper precipitate when reacted with reducing sugars liberated from exogenously supplied pectin. Using this technique, pectinase activity was examined in the nonarticulated, branched laticifers ofNerium oleander. Electron opaque crystalline deposits indicating the

R. D. Allen; C. L. Nessler



Studies on the constituents of the leaves of Nerium oleander on behavior pattern in mice  

Microsoft Academic Search

Fresh, undried and uncrushed leaves of Nerium oleander were subjected to methanol extraction and bioassay directed fractionation. This led to the isolation of two purified fractions namely, B-1 and B-3. Fractions B-1 and B-3 were studied with respect to their actions on the central nervous system and behavior pattern in mice. Both fractions were found to produce reduction in locomotor

Atiya Zia; Bina S. Siddiqui; Sabira Begum; Salimuzzaman Siddiqui; Amin Suria



Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.  


Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities. Herein, the hypolipidemic potential of the ethanolic extract of flowers of Nerium oleander (ENO) in a minimal dose was assessed. A high fat diet (HFD) resulted in a significant increase in cardiac lipids and lipoproteins and an increase in body weight gain. Simultaneous treatment with ENO significantly lowered the increase in body weight gain, lipid and lipoprotein levels, with a concomitant increase in HDL in the plasma and heart when compared to HFD-fed rats. Likewise, the activities of lipolytic enzymes were also upheld by the ENO treatment in the heart compared to HFD-fed rats. The above findings highlight the possible mechanism of N. oleander as a hypolipidemic agent in its use in folklore medicine as a cardiotonic. PMID:21726133

Gayathri, Veeraraghavan; Ananthi, Subhash; Chandronitha, Chandranayagam; Sangeetha, Marimuthu Kannan; Vasanthi, Hannah R



Biotransformation of 5?H-pregnan-3?ol-20-one and cardenolides in cell suspension cultures of Nerium oleander L  

Microsoft Academic Search

In order to demonstrate enzyme activities playing a role in the biosynthesis of cardenolides and 2,6-dideoxysugars, 5ßH-pregnan-3ßol-20-one and cardenolides (digitoxigenin, oleandrigenin\\/L-oleandrose, oleandrin, neriifolin, digitoxigeninmonodigitoxoside and strospeside) were fed to cell suspension cultures of Nerium oleander L.. It could be shown that cell suspension cultures of Nerium oleander L. are able to oxidize, isomerize and glucosylate 5ßH-steroidaglycones at C-3. The respective

Dietrich H. Paper; Gerhard Franz



Preliminary toxicity study on the individual and combined effects of Citrullus colocynthis and Nerium oleander in rats  

Microsoft Academic Search

The toxicity of diet containing 10% of Citrullus colocynthis fruits or 10% of Nerium oleander leaves or their 1:1 mixture (5%+5%) for rats treated for 6 weeks was determined. Dullness, ruffled hair, decreased body weight gains and feed efficiency, and enterohepatonephropathy characterised treatment with C. colocynthis and N. oleander given alone. Diarrhoea was a prominent sign of C. colocynthis poisoning.

M. A. Al-Yahya; A. H. AL-Farhan; S. E. I. Adam



A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning.  


Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) are potentially lethal plants after ingestion. Poisoning by these plants is a common toxicological emergency in tropical and subtropical parts of the world and intentional self-harm using T. peruviana is prevalent in South Asian countries, especially India and Sri Lanka. All parts of these plants are toxic, and contain a variety of cardiac glycosides including neriifolin, thevetin A, thevetin B, and oleandrin. Ingestion of either oleander results in nausea, vomiting, abdominal pain, diarrhoea, dysrhythmias, and hyperkalemia. In most cases, clinical management of poisoning by either N. oleander or T. peruviana involves administration of activated charcoal and supportive care. Digoxin specific Fab fragments are an effective treatment of acute intoxication by either species. However, where limited economic resources restrict the use of such Fab fragments, treatment of severely poisoned patients is difficult. Data from case reports and clinical studies were reviewed to identify treatments supported by evidence for the management of poisoning by N. oleander and T. peruviana. PMID:20438743

Bandara, Veronika; Weinstein, Scott A; White, Julian; Eddleston, Michael



Molecular, Biochemical and Physiological Characterization of Gibberellin Biosynthesis and Catabolism Genes from Nerium oleander  

Microsoft Academic Search

Genomic and cDNA clones encoding two gibberellin (GA) 20-oxidases (named NoGA20ox1 and -2) and three GA 2-oxidases (NoGA2ox1, -2, and -3) have been isolated and characterized from Nerium oleander L. (oleander), a plant of horticultural importance in the Mediterranean region. NoGA2ox2 and -3 transcripts were abundant in expanding leaves and flower buds, whereas NoGA20ox1, -2 and NoGA2ox1 transcripts were barely

Susana Ubeda-Tomás; José L. García-Martínez; Isabel López-Díaz



Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity.  


We evaluated the effectiveness of Anvirzel™, an aqueous extract of Nerium oleander on HIV infection of human peripheral blood mononuclear cells. Oleandrin, the principle cardiac glycoside (CG) in Anvirzel™ has been shown to exhibit anti-cancer properties but its efficacy against HIV is unknown. Treatment with Anvirzel™ significantly reduced the infectivity of virus produced from infected cells without any change in the total amount of virus produced. This is in contrast to treatment with AZT, a potent inhibitor of HIV replication that has been shown to significantly reduce virus production. Relative to untreated cultures, virus in cultures treated with oleandrin had significantly reduced expression of the envelope protein gp120, the sole determinant of virus infectivity, suggesting a novel mechanism underlying the impaired infectivity. These results support the potential utility of the Nerium oleander aqueous extract, containing the CG oleandrin as a novel candidate anti-HIV therapeutic. PMID:23127567

Singh, Shailbala; Shenoy, Sachin; Nehete, Pramod N; Yang, Peiying; Nehete, Bharti; Fontenot, Danielle; Yang, Guojun; Newman, Robert A; Sastry, K Jagannadha



Characterisation of acyl-ACP desaturases from Macadamia integrifolia Maiden & Betche and Nerium oleander L  

Microsoft Academic Search

The seed oil in Macadamia integrifolia contains about 30% palmitoleic acid (16:1?9) and Nerium oleander about 12% isoricinoleic acid (?9-hydroxy-18:1?12). It has been shown that palmitoleic acid can be produced by acyl-acyl carrier protein (ACP) desaturases and it has also been shown that fatty acid hydroxylation can occur via direct substitution of a hydrogen atom. Therefore it seemed possible that

Per O Gummeson; Marit Lenman; Michael Lee; Surinder Singh; Sten Stymne



Polar cardenolide monoglycosides from stems and twigs of Nerium oleander and their biological activities  

Microsoft Academic Search

Twelve polar cardenolide monoglycosides, 1, 2, 4–13, and oleagenin (3) were isolated from the methanol extract of stems and twigs of Nerium oleander. Among these, oleagenin (3) and cardenolide monoglycosides named cardenolide B-1 (1) and cardenolide B-2 (2) were isolated from natural sources for the first time. The in vitro antiinflammatory activity of compounds 1–13 was examined on the basis

Liming Bai; Ming Zhao; Asami Toki; Toshiaki Hasegawa; Jun-ichi Sakai; Xiao-yang Yang; Yuhua Bai; Hirotsugu Ogura; Tomokazu Mitsui; Takao Kataoka; Mariko Ando; Katsutoshi Hirose; Masayoshi Ando



Complete atrioventricular block after self-ingestion of Nerium oleander for relief of hemorrhoidal complaints.  


Nerium oleander is a plant native only in the Mediterranean region, but it can also be cultivated worldwide, particularly in warm areas. Biologically active oleander compounds may be used for therapeutic purposes. However, when used for self-medication, it may cause serious problems including death. We present a 30-year-old otherwise healthy man who developed complete atrioventricular block after taking a syrup of N. oleander leaves for self-medication to relive hemorrhoidal complaints. The patient was treated by oral administration of charcoal combined with sodium sulfate as well as electrolyte solutions and transient use of an external cardiac pacemaker. The atrioventricular block reverted to sinus rhythm in 30 hours and he was discharged in good hemodynamic status and general condition. PMID:22710590

Küçükdurmaz, Zekeriya; Karapinar, Hekim; Gül, Ibrahim; Yilmaz, Ahmet



Protein, leucine aminopeptidase, esterase, acid phosphatase and photosynthetic responses of oleander (Nerium oleander L.) during cold acclimation and freezing treatments.  


Six-month-old oleander (Nerium oleander L.) pot plants, derived from vegetative propagation by cuttings, were tested for their ability to cold hardening. Damage of the non-acclimated (NA) plants was visible when treated by low freezing temperatures (below -2 degrees C). The responses of total proteins, leucine aminopeptidase (LAP), esterase (EST) and acid phosphatase (ACP) isoforms of NA and cold-acclimated (CA; 4 degrees C for 14 days) plants were compared using polyacrylamide gel electrophoresis. These molecular markers were also compared in NA and CA plants which received for 2h temperatures of 0, -2, -4, -6 and -8 degrees C. A new 38-kDa polypeptide appeared from day 7 to 14 during the acclimation treatment in the bark extracts and on day 14 in the leaf extracts. The above-mentioned polypeptide band (38 kDa) strongly appeared in all freezing treatments (0, -2, -4, -6 and -8 degrees C) in both bark and leaf extracts of the CA plants. Alterations in the number and the intensity of LAP and EST isoforms as well as in the intensity of ACP isoforms were observed in both bark and leaf of the CA oleander plants. A newly expressed EST isoform is proposed as biochemical marker for the cold acclimation treatment. CO2 assimilation rates (A) as well as transpiration rates (E) in NA plants were positive in 0 degrees C and negative in all temperatures below zero in the freezing treatments. In contrast, CO2 assimilation rates (A) and transpiration rates (E) were positive in CA plants in all temperatures of freezing treatment. A significant decrease (P<0.05) in chlorophyll (Chl) a, Chl a+b concentration and Chl a/b ratio were noticed in oleander plants during the acclimation treatment (from day 0 to 14), while Chl b concentration was unchanged at the respective time. On the other hand, no significant (P<0.05) differences were observed in the freezing treatments. PMID:16146314

Syros, Thomas; Yupsanis, Traianos; Petkou, Demitrios; Economou, Athanasios S



The biological activities of cardenolide triglycosides from stems, twigs, and leaves of Nerium oleander  

Microsoft Academic Search

Sixteen cardenolide triglycosides (1–16) were isolated from stems, twigs, and leaves of Nerium oleander. Among them, 3?-O-(4-O-gentiobiosyl-d-diginosyl)-7?,8-epoxy-14-hydroxy-5?,14?-card-20(22)-enolide, named cardenolide B-3 (16), was isolated from natural sources for the first time. The in vitro anti-inflammatory activities of compounds 1–16 were examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Compounds\\u000a 1–5 were active at an

Yuhua Bai; Ming Zhao; Liming Bai; Ryo Hasegawa; Jun-ichi Sakai; Toshiaki Hasegawa; Tomokazu Mitsui; Hirotsugu Ogura; Takao Kataoka; Katsutoshi Hirose; Masayoshi Ando



Response of Najdi sheep to oral administration of Citrullus colocynthis fruits, Nerium oleander leaves or their mixture  

Microsoft Academic Search

Susceptibility of sheep to oral administration of Citrullus colocynthis fruits, Nerium oleander leaves or their mixture is described in 12 sheep assigned as untreated controls, C. colocynthis-treated at 0.25g\\/kg\\/day, N. oleander-treated at 0.25g\\/kg and plant mixture-treated at 0.25g of C.colocynthis\\/kg plus 0.25g of N. oleander\\/kg. The daily use of 0.25g of C. colocynthis\\/kg for 42 days was not fatal to

S. E. I. Adam; M. A. Al-Yahya; A. H. Al-Farhan




Microsoft Academic Search

The air pollution effects on the activity of antioxidant enzymes were investigated on Nerium oleander and Robinia pseudo acacia in Tehran. Considering the information obtained from the Department of the Environment of Iran, Sorkh Hesar Park as well as South Azadi were selected as two sampling sites representing the unpolluted and polluted area respectively. A number of plant leave samples

M. Ghorbanli; Z. Bakand; G. Bakhshi; S. Bakand



Synchrotron radiation X-ray fluorescence analysis of trace elements in Nerium oleander for pollution monitoring q  

Microsoft Academic Search

This works describes the use of synchrotron radiation fluorescence analysis as a technique for monitoring trace elements in bio-indicators for environmental pollution control. The analyses were performed on leaves of Nerium oleander collected in streets with different levels of traffic flow in Rio de Janeiro, Brazil, with one sample from a rural zone. The leaves were collected from adult trees

E. F. O. de Jesus; S. M. Simabucob U; M. J. dos Anjosc; R. T. Lopesa


Stimulation of oleandrin production by combined Agrobacterium tumefaciens mediated transformation and fungal elicitation in Nerium oleander cell cultures  

Microsoft Academic Search

Suspension cultures derived from Agrobacterium tumefaciens-transformed calli were established in Nerium oleander L. The presence of the bacterial T-DNA in the transformed calli was detected by the polymerase chain reaction as well as plant hormone autotrophy. The ability of the cultures to accumulate oleandrin was confirmed using high performance liquid chromatography. The effect of fungal elicitors prepared from Aspergillus niger

Amany K. Ibrahim; Sherief Khalifa; Ishrak Khafagi; Diaa Youssef; Ikhlas Khan; Mostafa Mesbah



Cardioprotective effect of Nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats.  


Nerium oleander Linn (NOL) an evergreen shrub belonging to the Apocynaceae family has been reported to have a wide spectrum of bioactivities. In in vitro study, the free radical scavenging potential of the hydroethanolic extract of N oleander Linn (ENO) flower and its fractions (glycosidic and nonglycosidic) were studied using 2, 2(')-azino-di [3-ethylbenzthiazoline sulphonate] (ABTS(*+) ) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH*) scavenging assay. ENO exhibited better radical scavenging activities than its fractions. Furthermore, the cardioprotective role of ENO (10, 30, 100 mg/kg, per oral [po]) was tested against isoproterenol-induced myocardial toxicity (ISO, 120 mg/kg per day, subcutaneously [sc], for 2 days at 48 hours interval) in experimental rats when compared to propranolol (5 mg/kg, po) which was the standard. Pretreatment with ENO (10, 30, and 100 mg/kg) and propranolol for 2 weeks followed by ISO challenge in rats prevented the elevation of marker enzymes such as lactate dehydrogenase (LDH), ?-glutamyl transferase (GGT), creatine kinase (CK-MB and creatine phosphokinase [CPK]), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in plasma. In addition, pretreatment with ENO and propranolol significantly attenuated the lipid peroxidation by maintaining the levels of enzymatic (superoxide dismutase and glutathione peroxidase) and nonenzymatic antioxidants (reduced glutathione and nitrite), which was also confirmed histologically. Taken together, the current study indicates that the hydroalcoholic extract of N oleander Linn flowers aid in cardioprotection probably by improving the antioxidant defense system during experimental myocardial necrosis. PMID:21191138

Gayathri, Veeraraghavan; Ananthi, Subhash; Chandronitha, Chandranayagam; Ramakrishnan, Ganapathy; Lakshmisundaram, Raman; Sundaram, Raman Lakshmi; Vasanthi, Hannah R



Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi.  


Anti-mycotic activity of the ethanol extracts from Nettle (Urtica dioica L.), Colocynth (Citrullus colocynthis L. Schrad), Konar (Ziziphus spina-christi L.) and Oleander (Nerium oleander L.) floral parts were screened in vitro against four important plant pathogenic fungi viz.; Alternaria alternate, Fusarium oxysporum, Fusarium solani and Rizoctonia solani using agar dilution bioassay. Extracts showed antifungal activity against all the tested fungi. Among the plants, Nettle and Colocynth were the most effective against A. alternate and R. solani while Oleander possesses the best inhibition on F. oxysporum and F. solani. Konar was the most effective extract by reducing the growth of Rizoctonia solani than other fungi. These results showed that extracts could be considered suitable alternatives to chemical additives for the control of fungal diseases in plants. PMID:19579919

Hadizadeh, I; Peivastegan, B; Kolahi, M



Microbial metabolism of biologically active secondary metabolites from Nerium oleander L.  


Ursolic acid (1) and kaempferol (3) are two major constituents of the Mediterranean plant Nerium oleander L. Microbial metabolism of (1) with Aspergillus flavus (ATCC 9170) resulted in the formation of 3-oxo-ursolic acid derivative, ursonic acid (2). On the other hand, Cunninghamella blakesleeana (ATCC 8688A) was able to convert (3) into kaempferol 3-O-beta-D-glucopyranoside (4) as well as the new natural product kaempferol 4'-sulfate (5). Incubation of kaempferol with Mucor ramannianus (ATCC 9628) led to the isolation of one metabolite identified as kaempferol 4'-O-alpha-L-rhamnopyranoside (6). Transformation of kaempferol to the new compound kaempferol 7-O-beta-D-4-O-methylglucopyranoside (7) and herbacetin 8-O-beta-D-glucopyranoside (8) was observed after fermentation with Beauveria bassiana (ATCC 13144). Cytotoxic as well as antioxidant activities of the isolated metabolites were determined. PMID:18758096

Ibrahim, Amany; Khalifa, Sherief Ibrahim; Khafagi, Ishrak; Youssef, Diaa Tohamy; Khan, Shabana; Mesbah, Mostafa; Khan, Ikhlas



Untersuchungen über die Biosynthese der Cyclite, 17. Mitt.: Bildung vond-bornesit und Dambonit in Nerium oleander  

Microsoft Academic Search

Dambonit (1,3-Di-O-methyl-myo-inosit) entsteht inNerium oleander, wie durch Einbauversuche mit radioaktiv markiertemmyo-Inosit undd-Bornesit sowie durch Bestimmung der Zeitabhängigkeit der Bildung der Cyclite bei Assimilation von14CO2 nachgewiesen wurde, ausmyo-Inosit überd-Bornesit als Zwischenprodukt. Neben Dambonit finden sich in der Cyclitfraktion vonN. oleander auchd-Bornesit,myo-Inosit sowiel-Leucanthemit.myo-Inosit unterliegt in der Pflanze-besonders im Winter-einem sehr intensiven Stoffwechsel, der zu nichtzyklischen Verbindungen führt.

H. Kindl; O. Hoffmann-Ostenhof



Atividade alelopática de Nerium Oleander L. e Dieffenbachia picta schott em sementes de Lactuca Sativa L. e Bidens pilosa L  

Microsoft Academic Search

SUMMARY Aqueous extracts from green leaves of Nerium oleander L. and Dieffenbachia picta in concentrations of 0; 0,0625; 0,125 and 0,25 mg\\/mL were prepared with the objective of studying the allelopathic potential of these ornamental plant species on lettuce (test plant) and Bidens pilosa L seeds. The experiments were carried out in January of 2007, at the Genetic Laboratory of

Clairomar Emílio; Flores Hoffmann; Luiz Augusto; Cristiane Freitas Bastos; Gabriel da Luz Wallau


Photoinhibition of photosynthesis: effect on chlorophyll fluorescence at 77K in intact leaves and in chloroplast membranes of Nerium oleander  

Microsoft Academic Search

The effect of exposing intact leaves and isolated chloroplast membranes of Nerium oleander L. to excessive light levels under otherwise favorable conditions was followed by measuring photosynthetic CO2 uptake, electron transport and low-temperature (77K=-196°C) fluorescence kinetics. Photoinhibition, as manifested by a reduced rate and photon (quantum) yield of photosynthesis and a reduced electron transport rate, was accompanied by marked changes

Stephen B. Powles; Olle Björkman



Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity.  


A pentacyclic triterpene, oleanderocioic acid, two flavonoidal glycosides, quercetin-5-O-[?-L-rhamnopyranosyl-(1?6)]-?-D-glucopyranoside and kaempferol-5-O-[?-L-rhamnopyranosyl-(1?6)-?-D-glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium oleander. Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines. PMID:22281382

Siddiqui, Bina Shaheen; Khatoon, Nasima; Begum, Sabira; Farooq, Ahsana Dar; Qamar, Kehkashan; Bhatti, Huma Aslam; Ali, Syed Kashif



The composition and relationships between trace element levels in inhalable atmospheric particles (PM 10) and in leaves of Nerium oleander L. and Lantana camara L  

Microsoft Academic Search

In order to evaluate the composition of inhalable atmospheric particles and to study the relationship between trace element levels in PM10 and in leaves of two plant species, the amount of Ba, Cu, Fe, Mn, Pb, Ti and V were analysed in PM10 and in Nerium oleander L. and Lantana camara L. leaves from two sites in the city of

A. J. Fernández Espinosa; S. Rossini Oliva




Microsoft Academic Search

Polycyclic Aromatic Hydrocarbons (PAH) were determined in the leaves of Nerium oleander L. an evergreen plant that occurs widely in both urban and rural areas, to monitor the degree of pollution in the urban area of Palermo (Italy) compared to remote areas. Twenty sites (urban roadside, urban, urban park, suburban and rural) in and around Palermo city were investigated.The purpose

Loredana Culotta; Antonio Gianguzza; Santino Orecchio



Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.  


We present a case of oleander leaf extract poisoning manifested by vomiting, lightheadedness, and heart block. Practicing physicians should understand the potential lethal properties of oleander and its availability throughout the world. PMID:21577379

Khan, Ibraheem; Kant, Chandra; Sanwaria, Anil; Meena, Lokesh



Metal uptake and distribution in cultured seedlings of Nerium oleander L. (Apocynaceae) from the Río Tinto (Huelva, Spain).  


Nerium oleander L. (Apocynaceae) is a micro-nano phanerophyte that grows in the riverbanks of the Río Tinto basin (Southwest Iberian Peninsula). The waters and soils of the Río Tinto area are highly acidic and have high concentrations of heavy metals. In this environment, N. oleander naturally grows in both extreme acidic (EA) and less extreme acidic (LEA) water courses, excluding, and bioindicating certain metals. In this work, we compared and evaluated the accumulation preferences and capacities, the distribution and processes of biomineralization of metals (Fe, Cu, Zn, Mn, Mg, Ca) in the first stages of growth of EA and LEA oleanders by means of inductively coupled plasma-mass spectrometry, scanning electron microscopy, and energy dispersive X-ray analyzer analysis. Seeds from both environments were grown and treated with a self-made solution simulating the most extreme red waters from the Río Tinto. LEA plants drastically reduces the metal uptake at the beginning, but later reactivates the uptake reaching concentration values in the same range as the EA plants. The results showed high Mn, Zn and Mg concentrations, accumulation of Fe and Cu in plants from both environments, differing from the metal concentrations of field-grown oleanders. Iron bioformations with traces of other metals were present inside and over epidermal cells and inside vascular cells of stems and roots. They were absent of leaves. The accumulation properties of N. oleander in its early stages of development make it a species to take in consideration in phytoremediation processes but optimized conditions are needed to ensure enough biomass production. PMID:23892697

Franco, Alejandro; Rufo, Lourdes; Zuluaga, Javier; de la Fuente, Vicenta



Nerium oleander indirect leaf photosynthesis and light harvesting reductions after clipping injury or Spodoptera eridania herbivory: high sensitivity to injury.  


Variable indirect photosynthetic rate (P(n)) responses occur on injured leaves after insect herbivory. It is important to understand factors that influence indirect P(n) reductions after injury. The current study examines the relationship between gas exchange and chlorophyll a fluorescence parameters with injury intensity (% single leaf tissue removal) from clipping or Spodoptera eridania Stoll (Noctuidae) herbivory on Nerium oleander L. (Apocynaceae). Two experiments showed intercellular [CO(2)] increases but P(n) and stomatal conductance reductions with increasing injury intensity, suggesting non-stomatal P(n) limitation. Also, P(n) recovery was incomplete at 3d post-injury. This is the first report of a negative exponential P(n) impairment function with leaf injury intensity to suggest high N. oleander leaf sensitivity to indirect P(n) impairment. Negative linear functions occurred between most other gas exchange and chlorophyll a fluorescence parameters with injury intensity. The degree of light harvesting impairment increased with injury intensity via lower (1) photochemical efficiency indicated lower energy transfer efficiency from reaction centers to PSII, (2) photochemical quenching indicated reaction center closure, and (3) electron transport rates indicated less energy traveling through PSII. Future studies can examine additional mechanisms (mesophyll conductance, carbon fixation, and cardenolide induction) to cause N. oleander indirect leaf P(n) reductions after injury. PMID:22325884

Delaney, Kevin J



Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model.  


The present study is aimed to assess the therapeutic potential of sulfonylurea drug glimepiride in comparison with Nerium oleander plant extract on insulin, glucose levels and some liver enzymes activities in streptozotocin-induced diabetic rats. Rats were rendered diabetic by intraperitoneal injection of a single dose of 50 mg kg(-1) body weight streptozotocin. Rats with serum glucose levels > 200 mg dL(-1) were subdivided into three sub-groups: the first sub-group were remained without treatment and considered as diabetics. The second and third subgroups were orally administered 0.1 mg kg(-1) body weight/day glimepiride and 250 mg kg(-1) body weight/day Nerium oleander, respectively for 4 weeks. Streptozotocin-induced diabetic rats showed hypoinsulinemia and hyperglycemia compared to controls. Strong negative correlation (r = -0.8) was found between serum insulin and glucose levels in diabetic rats. This correlation was +0.4 and -0.3 in glimepiride and Nerium olender-treated rats, respectively implying that glimepiride and plant extract improved insulin and glucose levels with the former was more efficient. The activities of serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were significantly increased in streptozotocin-induced diabetic rats compared to controls. Treatment of diabetic rats with glimepiride or Nerium oleander extract also improved liver enzymes activities. PMID:22514888

Mwafy, Saleh N; Yassin, Maged M



Dithiothreitol, an inhibitor of violaxanthin de-epoxidation, increases the susceptibility of leaves of Nerium oleander L. to photoinhibition of photosynthesis  

Microsoft Academic Search

Leaves ofNerium oleander L. plants, which had been previously kept in a shaded glasshouse for at least two months, were fed 1 mM dithiothreitol (DTT)\\u000a through their petioles, either for 12h in darkness (overnight) or for 2h in low light (28 ?mol photons·m?2·s?1), in each case followed by a 3-h exposure to high light (1260 ?mol photons·m?2·s?1). During exposure to

Klaus Winter; Martina Kiiniger



Injured and uninjured leaf photosynthetic responses after mechanical injury on Nerium oleander leaves, and Danaus plexippus herbivory on Asclepias curassavica leaves  

Microsoft Academic Search

Insect herbivory has variable effects on plant physiology; so greater understanding is needed about how injury alters photosynthesis\\u000a on individual injured and uninjured leaves. Gas exchange and light-adapted leaf chlorophyll fluorescence measurements were\\u000a collected from uninjured and mechanical partial leaf defoliation in two experiments with Nerium oleander (Apocynaceae) leaves, and one experiment with Danaus plexippus herbivory on Asclepias curassavica (Asclepiadaceae)

Kevin J. Delaney



Prophylactic and therapeutic effects of garlic extract on Nerium oleander-induced arrhythmia: a new approach to antiarrhythmic therapy in an ovine model.  


Abstract Context. Oleander is a potent cardiotoxic plant and is a common cause of poisoning in human and animals. There is no affordable and cost-effective treatment for oleander poisoning. Objective. To evaluate the prophylactic and therapeutic effects of garlic extract (Allium sativum) on Nerium oleander (a potent cardiotoxic plant) intoxication in sheep. Materials and methods. Eight sheep were intravenously infused with an unsterilized hydro-ethanol extract of garlic (50 mg/kg) before or after receiving a lethal dose of dried leaves (as a powder) of oleander (100 mg/kg, orally). The cardiac rhythm was continuously monitored using biopotential wireless transmitters and telemetry system. For evaluation of therapeutic effects, six sheep received the lethal dose of oleander and were administered with garlic extract after development of cardiac arrhythmias. Subsequently, the survived animals from the therapeutic study (four sheep) were administered with oleander without receiving any medication. Some blood constituents, including total antioxidant capacity, malondialdehyde, and troponin I, were compared between treated and untreated animals. Results. Pretreatment with garlic extract reversed the arrhythmia caused by oleander to its previous normal rhythm in seven sheep, but, one sheep died of ventricular fibrillation. On therapeutic treatment, four sheep survived while two died of ventricular fibrillation. Dosing with oleander without receiving garlic extract resulted in death of all sheep due to ventricular fibrillation. Blood constituents did not show any significant changes between treated and untreated sheep, and before and after intoxication. Conclusions. Garlic extract reduced the case fatality from 100% to 12.5% and 33.3% as a prophylactic or therapeutic agent, respectively. Additionally, garlic extract delayed the time of onset of arrhythmias and prolonged the interval between intoxication and death of the animals. Garlic extract could be considered to be a potential and affordable antidote in oleander poisoning. However additional studies with a larger sample size and in other species need to be performed to confirm the results in this study. PMID:23944745

Fattahi, M; Dalir-Naghadeh, B; Maham, M



The structure of a new cardenolide diglycoside and the biological activities of eleven cardenolide diglycosides from Nerium oleander.  


A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2-11. The structure of compound 1 was established on the basis of their spectroscopic data. The in vitro anti-inflammatory activity of compounds 1-11 was examined on the basis of inhibitory activity against the induction of the intercellular adhesion molecule-1 (ICAM-1). Compounds 2-5 were active at an IC(50) value of less than 0.8 µM. The cytotoxicity of compounds 1-11 was evaluated against three human cell lines normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), and human liver tumor cells (HepG2). Compound 3 was active toward VA-13 cells, and compounds 2-5 were active toward HepG2 cells at IC(50) values of less than 1.3 µM. The multidrug resistance (MDR)-reversal activity of compounds 1-11 was evaluated on the basis of the amount of calcein in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1 and 8 showed moderate effects on calcein accumulation. PMID:21372420

Zhao, Ming; Bai, Liming; Toki, Asami; Hasegawa, Ryo; Sakai, Jun-ichi; Hasegawa, Toshiaki; Ogura, Hirotsugu; Kataoka, Takao; Bai, Yuhua; Ando, Mariko; Hirose, Katsutoshi; Ando, Masayoshi



Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats.  


Diabetes was induced by intraperitoneal injection of streptozotocin (35?mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375??g/0.5?mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6?mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor- (PPAR-) ?, ?, and ? in adipose tissue and PPAR-?-? in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375??g/0.5?mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes. PMID:23251156

Bas, Ahmet Levent; Demirci, Sule; Yazihan, Nuray; Uney, Kamil; Ermis Kaya, Ezgi



The Nerium oleander aphid Aphis nerii is tolerant to a local isolate of Aphid lethal paralysis virus (ALPV).  


In a survey that was conducted during the year 2011, a local strain of Aphid lethal paralysis virus (ALPV) was identified and isolated from a wild population of Aphis nerii aphids living on Nerium oleander plants located in northern Israel. The new strain was tentatively named (ALPV-An). RNA extracted from the viral particles allowed the amplification and determination of the complete genome sequence. The virus genome is comprised of 9835 nucleotides. In a BLAST search analysis, the ALPV-An sequence showed 89 % nucleotide sequence identity with the whole genome of a South African ALPV and 96 and 94 % amino acid sequence identity with the ORF1 and ORF2 of that strain, respectively. In preliminary experiments, spray-applied, purified ALPV virions were highly pathogenic to the green peach aphid Myzus persicae; 95 % mortality was recorded 4 days post-infection. These preliminary results demonstrate the potential of ALPV for use as a biologic agent for some aphid control. Surprisingly, no visible ALPV pathogenic effects, such as morphological changes or paralysis, were observed in the A. nerii aphids infected with ALPV-An. The absence of clear ALPV symptoms in A. nerii led to the formulation of two hypotheses, which were partially examined in this study. The first hypothesis suggest that A. nerii is resistant or tolerant of ALPV, while the second hypothesis propose that ALPV-An may be a mild strain of ALPV. Currently, our results is in favor with the first hypothesis since ALPV-An is cryptic in A. nerii aphids and can be lethal for M. persicae aphids. PMID:23229204

Dombrovsky, Aviv; Luria, Neta



Platinum and rhodium associated with the leaves of Nerium oleander L.; analytical method using voltammetry; assessment of air quality in the Palermo (Italy) area.  


A rapid accumulation of the catalytic active noble metals in the environmental and biological matrices was observed and concern arose about potential environmental and health risks. The development of reliable analytic methods to measure very low Pt and Rh concentrations is required. The main purpose of this work was to develop a reliable method for the determination of Pt and Rh in environmental matrices because of inherent difficulties in using conventional techniques used, in particular, the ICP-OES technique. A direct determination of Pt using ICP-MS, for instance, is problematic, due to interfering signals. In this work, differential pulse voltammetry (DPV/a) and adsorptive stripping voltammetry (AdSV) were used for the determination of Pt and Rh in Nerium oleander leaves. Pt and Rh concentrations were found in the ranges 0.33-25 and 0.40-4.6 microg/kg d.w., respectively. We carried out linear regression analysis between total PAH concentrations in leaves of oleander and of Quercus ilex measured in previous researches and the data obtained in this work. The high correlation coefficients were obtained; which demonstrates that oleander leaves can be used to establish the presence and the distribution of pollutants in a chosen area. PMID:19846253

Orecchio, Santino; Amorello, Diana



Change in Uptake, Transport and Accumulation of Ions in Nerium oleander (Rosebay) as Affected by Different Nitrogen Sources and Salinity  

PubMed Central

Background and Aims The source of nitrogen plays an important role in salt tolerance of plants. In this study, the effects of NaCl on net uptake, accumulation and transport of ions were investigated in Nerium oleander with ammonium or nitrate as the nitrogen source in order to analyse differences in uptake and cycling of ions within plants. Methods Plants were grown in a greenhouse in hydroponics under different salt treatments (control vs. 100 mm NaCl) with ammonium or nitrate as the nitrogen source, and changes in ion concentration in plants, xylem sap exuded from roots and stems, and phloem sap were determined. Key Results Plant weight, leaf area and photosynthetic rate showed a higher salt tolerance of nitrate-fed plants compared with that of ammonium-fed plants. The total amount of Na+ transported in the xylem in roots, accumulated in the shoot and retranslocated in the phloem of ammonium-fed plants under salt treatment was 1·8, 1·9 and 2·7 times more, respectively, than that of nitrate-treated plants. However, the amount of Na+ accumulated in roots in nitrate-fed plants was about 1·5 times higher than that in ammonium-fed plants. Similarly, Cl? transport via the xylem to the shoot and its retranslocation via the phloem (Cl? cycling) were far greater with ammonium treatment than with nitrate treatment under conditions of salinity. The uptake and accumulation of K+ in shoots decreased more due to salinity in ammonium-fed plants compared with nitrate-fed plants. In contrast, K+ cycling in shoots increased due to salinity, with higher rates in the ammonium-treated plants. Conclusions The faster growth of nitrate-fed plants under conditions of salinity was associated with a lower transport and accumulation of Na+ and Cl? in the shoot, whereas in ammonium-fed plants accumulation and cycling of Na+ and Cl? in shoots probably caused harmful effects and reduced growth of plants.

Abdolzadeh, Ahmad; Shima, Kazuto; Lambers, Hans; Chiba, Kyozo



Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat  

PubMed Central

To gain insight into the hepatohistological alterations in noninjured rat liver, Nerium oleander (N.O.) leaves extract was injected intramuscularly to induce an acute phase reaction (APR). Histopathological changes were studied after 3, 12, and 24?h time course of sterile muscle abscess. Tissue integrity and any infiltration of inflammatory cells in the liver were investigated by Hematoxylin and Eosin and ED1 peroxidase stainings. The administration of N.O. leaves extract (10?mL/kg) in H & E stained sections showed a general vacuolization of cytoplasm resulting loss of polarity with prominent nucleoli after 3?h of induction. At 12?h, eccentric nuclei were also observed in the sections. Marked infiltration of leucocytes with predominate macrophages was also found after 24?h as seen by ED1 positive staining. In the present study, a possible relationship between serum hepcidin and total iron level was also investigated in vivo. An early increase of hepcidin and total iron level (3?h) with a maximum at 12?h (P < 0.01; P < 0.001) was observed. These changes indicate that sterile muscle abscess may induce APR resulting in hepatic damage which is evident with the recruitment of inflammatory cells into the organ.

Abbasi, Muddasir Hassan; Fatima, Sana; Naz, Naila; Malik, Ihtzaz A.



In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.  


The principal active constituent of the botanical drug candidate PBI-05204, a supercritical CO(2) extract of Nerium oleander, is the cardiac glycoside oleandrin. PBI-05204 shows potent anticancer activity and is currently in phase I clinical trial as a treatment for patients with solid tumors. We have previously shown that neriifolin, which is structurally related to oleandrin, provides robust neuroprotection in brain slice and whole animal models of ischemic injury. However, neriifolin itself is not a suitable drug development candidate and the FDA-approved cardiac glycoside digoxin does not cross the blood-brain barrier. We report here that both oleandrin as well as the full PBI-05204 extract can also provide significant neuroprotection to neural tissues damaged by oxygen and glucose deprivation as occurs in ischemic stroke. Critically, we show that the neuroprotective activity of PBI-05204 is maintained for several hours of delay of administration after oxygen and glucose deprivation treatment. We provide evidence that the neuroprotective activity of PBI-05204 is mediated through oleandrin and/or other cardiac glycoside constituents, but that additional, non-cardiac glycoside components of PBI-05204 may also contribute to the observed neuroprotective activity. Finally, we show directly that both oleandrin and the protective activity of PBI-05204 are blood brain barrier penetrant in a novel model for in vivo neuroprotection. Together, these findings suggest clinical potential for PBI-05204 in the treatment of ischemic stroke and prevention of associated neuronal death. PMID:21950737

Dunn, Denise E; He, Dong Ning; Yang, Peiying; Johansen, Mary; Newman, Robert A; Lo, Donald C



Effect of Nerium oleander (N.O.) Leaves Extract on Serum hepcidin, Total Iron, and Infiltration of ED1 Positive Cells in Albino Rat.  


To gain insight into the hepatohistological alterations in noninjured rat liver, Nerium oleander (N.O.) leaves extract was injected intramuscularly to induce an acute phase reaction (APR). Histopathological changes were studied after 3, 12, and 24?h time course of sterile muscle abscess. Tissue integrity and any infiltration of inflammatory cells in the liver were investigated by Hematoxylin and Eosin and ED1 peroxidase stainings. The administration of N.O. leaves extract (10?mL/kg) in H & E stained sections showed a general vacuolization of cytoplasm resulting loss of polarity with prominent nucleoli after 3?h of induction. At 12?h, eccentric nuclei were also observed in the sections. Marked infiltration of leucocytes with predominate macrophages was also found after 24?h as seen by ED1 positive staining. In the present study, a possible relationship between serum hepcidin and total iron level was also investigated in vivo. An early increase of hepcidin and total iron level (3?h) with a maximum at 12?h (P < 0.01; P < 0.001) was observed. These changes indicate that sterile muscle abscess may induce APR resulting in hepatic damage which is evident with the recruitment of inflammatory cells into the organ. PMID:24069586

Abbasi, Muddasir Hassan; Fatima, Sana; Naz, Naila; Malik, Ihtzaz A; Sheikh, Nadeem



Unexpected double lethal oleander poisoning.  


Nerium oleander is a very popular urban ornamental plant in Europe, but it is also extremely dangerous because it contains several types of glycosides, accidental ingestion of which can cause cardiac arrhythmias and even deaths. The rarity of such cases makes it difficult to think of oleander poisoning without evidences that suggest this possibility as the cause of the unexpected death. This report concerns the discovery of the bodies of 2 young people, a man and a woman, in a forest in conditions of extreme malnutrition. Medicolegal investigations showed neither pathologic nor traumatic causes of death, but the presence of vegetal remains in the stomach was noticed. A common toxicological analysis resulted negative, but the implementation of more detailed investigations showed the presence of digoxin in the blood of both cadavers, excluding the possibility of a pharmaceutical provenience of digoxin, this laboratory result was interpreted as evidence of ingestion of oleander, which contains oleandrine, the cross reaction of which with digoxin is widely described in the literature. Identification of the 2 subjects, which occurred after 4 years, strengthened the hypothesis of accidental poisoning by oleander because it was ascertained that the 2 young people were vegans--extreme vegetarians who reject the ingestion of foods of animal origin and live by eating only what they find in nature. PMID:21926903

Papi, Luigi; Luciani, Alessandro Bassi; Forni, David; Giusiani, Mario



New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway  

Microsoft Academic Search

Most of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (A?) peptides or deprivation of nutrition from serum. In

Man-Shan Yu; Anita Yuk-Yee Wong; Kwok-Fai So; Ji-Nian Fang; Wai-Hung Yuen; Raymond Chuen-Chung Chang



The effect of urban ground cover on microclimate, growth and leaf gas exchange of oleander in Phoenix, Arizona  

NASA Astrophysics Data System (ADS)

We assessed how small patches of contrasting urban ground cover [mesiscape (turf), xeriscape (gravel), concrete, and asphalt] altered the microclimate and performance of adjacent oleander (Nerium oleander L.) plants in Phoenix, Arizona during fall/winter (September February) and spring/summer (March September). Ground-cover and oleander canopy surface temperatures, canopy air temperatures and pot soil temperatures tended to be lowest in the mesiscape and highest in the asphalt and concrete. Canopy air vapor pressure deficits were lowest in the mesiscape and highest in the asphalt plot. Rates of net photosynthesis of all oleander plants were highest in October and May, and declined through mid-summer (June July), when rates tended to be highest in the cooler mesiscape, particularly when water was limiting. During fall/winter, oleanders in the mesiscape produced 20% less biomass, 13% less leaf area, and had 12% lower relative growth rates (RG) than those in the other ground covers. Lower nighttime temperatures in the mesiscape in December led to oleander frost damage. During spring/summer, oleanders in the mesiscape produced 11% more biomass, 16% more leaf area, and had 3% higher RG than those in the other cover types. The effects of urban ground cover on oleander performance were season-specific; while oleander growth was greatest in the mesiscape during spring/summer, it was lowest during fall/winter and these plants experienced frost damage. Because all oleander plants produced >10 times as much biomass during the spring/summer, on an annual basis oleanders in the mesiscape produced 5 11% more biomass than plants in the warmer ground covers.

Mueller, Erin C.; Day, Thomas A.



Electrocardiographic changes during inhalational oleander toxicity.  


Inhalational oleander toxicity was considered in a family of 4 by history of exposure to smoke from burning oleander twigs. Electrocardiography revealed first- and second-degree atrioventricular block with digoxin-like ST-T-wave changes, suggestive of oleander toxicity in the absence of exposure to digoxin or other herbal medicines, and without systemic illness. Complete blood count, biometabolic profile, chest x-ray, and echocardiography did not reveal any abnormalities. Electrocardiographies normalized within 4 days when kept away from offending agents. Because oleander plant materials are used for burning, people are exposed to inhalational oleander toxicity. Hence, practitioners shall consider such poisonings in them. PMID:21397908

Senthilkumaran, Subramanian; Meenakshisundaram, Ramachandran; Michaels, Andrew D; Thirumalaikolundusubramanian, Ponniah



Structural characterization of a pectic polysaccharide from Nerium indicum flowers.  


A polysaccharide fraction, J6, was isolated from the hot-water extract of flowers of oleander Nerium indicum Mill., using ethanol precipitation, cetyltrimethylammonium bromide (CTAB) complexing, anion-exchange chromatography and gel permeation chromatography. J6 was found to contain L-rhamnose, L-arabinose, D-galactose, and D-galacturonic acid, in the ratio of 10.1:49.8:30.1:10.0. Its structure was investigated by methylation analysis, periodate oxidation, Smith degradation, partial acid hydrolysis, electrospray ionization mass spectrometry and NMR spectroscopic methods. It was found that J6 is an RG-I type polysaccharide, which contains a rhamnogalacturonan backbone, with various branches attached to O-4 of L-rhamnose. The branches probably involve (1-->4)-beta-D-galactan, branched L-arabino-(1-->3)(1-->6)-beta-D-galactan, and (1-->5)-alpha-L-arabinan. J6 stimulated NO production of macrophage RAW264.7 cells in a preliminary test. PMID:20573364

Dong, Qun; Liu, Xuan; Yao, Jian; Dong, Xiaotang; Ma, Chao; Xu, Yuxia; Fang, Jinian; Ding, Kan



Evidence for the biosynthetic pathway from sinapic acid to syringyl lignin using labeled sinapic acid with stable isotope at both methoxy groups in Robinia pseudoacacia and Nerium indicum.  


A tracer experiment using synthesized labeled lignin precursors was designed to confirm the actual biosynthetic pathway for syringyl lignin. Tetradeuteroferulic acid-[8-D, 3-OCD(3)] and heptadeuterosinapic acid-[8-D, 3,5-OCD(3)] were synthesized and fed to shoots of robinia (Robinia pseudoacacia) and oleander (Nerium indicum) trees. The incorporation of each labeled precursor into lignin was traced by gas chromatography-mass spectrometry. The synthesized sinapic acid, in which both methoxy groups were labeled, was useful in monitoring the conversion of sinapic acid into syringyl lignin. When heptadeuterosinapic acid was fed, syringyl units containing seven deuterium labels were detected. The results of this study support the traditionally accepted pathway that sinapic acid is converted to sinapyl alcohol via sinapoyl-CoA in robinia and oleander. PMID:12009990

Yamauchi, Kazuchika; Yasuda, Seiichi; Fukushima, Kazuhiko



Evidence for an Invasive Aphid "Superclone": Extremely Low Genetic Diversity in Oleander Aphid (Aphis nerii) Populations in the Southern United States  

PubMed Central

Background The importance of genetic diversity in successful biological invasions is unclear. In animals, but not necessarily plants, increased genetic diversity is generally associated with successful colonization and establishment of novel habitats. The Oleander aphid, Aphis nerii, though native to the Mediterranean region, is an invasive pest species throughout much of the world. Feeding primarily on Oleander (Nerium oleander) and Milkweed (Asclepias spp.) under natural conditions, these plants are unlikely to support aphid populations year round in the southern US. The objective of this study was to describe the genetic variation within and among US populations of A. nerii, during extinction/recolonization events, to better understand the population ecology of this invasive species. Methodology/Principal Findings We used five microsatellite markers to assess genetic diversity over a two year period within and among three aphid populations separated by small (100 km) and large (3,700 km) geographic distances on two host plant species. Here we provide evidence for A. nerii “superclones”. Genotypic variation was absent in all populations (i.e., each population consisted of a single multilocus genotype (MLG) or “clone”) and the genetic composition of only one population completely changed across years. There was no evidence of sexual reproduction or host races on different plant species. Conclusions/Significance Aphis nerii is a well established invasive species despite having extremely low genetic diversity. As this aphid appears to be obligatorily asexual, it may share more similarities with clonally reproducing invasive plants, than with other animals. Patterns of temporal and geographic genetic variation, viewed in the context of its population dynamics, have important implications for the management of invasive pests and the evolutionary biology of asexual species.

Harrison, John Scott; Mondor, Edward B.



Cutaneous absorption of Oleander: Fact or fiction  

PubMed Central

Cardiac conduction disorders following oral ingestion of Oleander plant materials were documented earlier. Transcutaneous absorption of yellow oleander (Thevetia peruviana) leaf extract applied over non intact skin (raw wound) resulting in reversible cardiac conduction disorder observed in four healthy males who were free from any other systemic or electrolyte or metabolic disorders or exposure to pesticide or toxins is reported for the first time. Their hematological, biochemical, clinical, and echocardiogram status were within normal limits and free of any abnormalities. One among the four, presented for weakness and breathlessness (class II). He had bradycardia with Mobitz II block and hypotension without any other demonstrable localizing signs. The other three were identified in the community and without any symptoms. However, their ECG revealed bradycardia with Mobitz I block in two and complete heart block in the other. All of the four recovered well without any untoward events. Hence, it is suggested that physicians and practitioners have to elicit history and route of administration of unconventional therapy, whenever they are confronted with clinical challenges and during medical emergencies before embarking final decision.

Senthilkumaran, S; Saravanakumar, S; Thirumalaikolundusubramanian, P



Nematicidal cardenolides from Nerium indicum Mill.  


Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) and cardenolide N-1 (3). The median lethal concentrations (LC(50)) of compounds 1-3 against the nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, and Caenorhabditis elegans at 72 h were 103.3, 49.0, and 45.4 mg l(-1), 257.0, 62.7, and 177.8 mg l(-1), and 242.9, 29.1, and 41.7 mg l(-1), respectively. This is the first report about the nematicidal activity of cardenolides. PMID:19319871

Wang, Xing-Biao; Li, Guo-Hong; Zheng, Li-Jun; Ji, Kai-Yan; Lü, Hua; Liu, Fang-Fang; Dang, Li-Zhi; Mo, Ming-He; Zhang, Ke-Qin



Nerium oleander indirect leaf photosynthesis and light harvesting reductions after clipping injury or Spodoptera eridania herbivory: High sensitivity to injury  

Technology Transfer Automated Retrieval System (TEKTRAN)

Variable indirect photosynthetic rate (Pn) responses occur on injured leaves after insect herbivory. It is important to understand factors that influence indirect Pn reductions after injury. The current study examines the relationship between gas exchange and chlorophyll a fluorescence parameters wi...


Specific detection and identification of Xylella fastidiosa strains causing oleander leaf scorch using polymerase chain reaction.  


A pair of PCR primers, QH-OLS05/QH-OLS08 specific for strains of Xylella fastidiosa causing oleander leaf scorch was developed. The primers were designed according to a DNA sequence of a randomly amplified polymorphic DNA (RAPD)-polymerase chain reaction (PCR) product unique to oleander strains. The PCR assay using primer pair QH-OLS05/QH-OLS08 allowed quick and simple detection and identification of oleander strains in cultured bacterium and infected plant samples. The assay also can be applied to insect samples. Specific detection and identification of oleander strains of X. fastidiosa by PCR is useful for epidemiologic and etiologic studies of oleander leaf scorch by identifying what plants and insect vectors harbor or carry this particular strain of X. fastidiosa, especially in locations where mixed natural infections by oleander and other strains of X. fastidiosa occur. PMID:19020933

Huang, Qi



Controlling the Spread of XYLELLA FASTIDIOSA, the Causal Agent of Oleander Leaf Scorch, by Disrupting Vector Acquisition and Transmission.  

National Technical Information Service (NTIS)

Oleander Leaf Scorch (OLS) is a devastating disease of oleander induced by the bacterium Xylella fastidiosa. The Glassy-winged Sharpshooter (GWSS, Homalodisca coagulate) spreads the OLS bacterium during feeding by first acquiring it from infected plants a...

M. J. Blua R. A. Redak H. S. Costas




Technology Transfer Automated Retrieval System (TEKTRAN)

Bacterial leaf scorch caused by Xylella fastidiosa has been reported on oleander in California and Florida. Recently, leaf scorch symptoms were observed in oleanders at various locations in Texas. The symptomatic varieties from Moody Gardens in Galveston, Texas reacted positively in ELISA, and colo...


Rapid detection of oleander poisoning by Dimension Vista digoxin assay (Flex Reagent Cartridge).  


Oleander poisoning can be detected by digoxin immunoassays and for last two decades the fluorescence polarization immunoassay (FPIA) has been used for rapid detection of oleander poisoning in clinical laboratories. Recently, Abbott Laboratories (Abbott Park, IL) discontinued this assay. Therefore, we explored the possibility of using another digoxin assay (Dimension Vista Flex Reagent Cartridge, Tina Quant, EMIT 2000 and old FPIA assay for comparison) for rapid detection of oleander poisoning. When aliquots of drug-free serum pools were supplemented with pure oleandrin or oleander extract, we observed the highest apparent digoxin values using Dimension Vista digoxin assay (Flex Reagent Cartridge). We also observed significant apparent digoxin values in vivo in sera of mice both 1 and 2 ?hr after feeding with oleander extract. When a serum pool prepared from patients taking digoxin was further supplemented with various amounts of oleander extract, the highest falsely elevated digoxin values were observed with Dimension Vista digoxin assay. Monitoring free digoxin using Dimension Vista digoxin assay (Flex Reagent Cartridge) did not eliminate this interference. Digibind neutralized digoxin-like factors of oleander extract and such effect can be monitored by observing significant reduction in apparent free digoxin levels in the presence of Digibind as measured in the protein-free ultrafiltrate using Dimension Vista digoxin assay (Flex Reagent Cartridge). PMID:21438002

Dasgupta, Amitava; Klein, Kimberley; Risin, Semyon A; Actor, Jeffrey K



Platinum and rhodium associated with the leaves of Nerium oleander L.; analytical method using voltammetry; assessment of air quality in the Palermo (Italy) area  

Microsoft Academic Search

A rapid accumulation of the catalytic active noble metals in the environmental and biological matrices was observed and concern arose about potential environmental and health risks. The development of reliable analytic methods to measure very low Pt and Rh concentrations is required. The main purpose of this work was to develop a reliable method for the determination of Pt and

Santino Orecchio; Diana Amorello



Synthesis of oligosaccharide fragments of the rhamnogalacturonan of Nerium indicum.  


Three trisaccharides, one pentasaccharide, and one heptasaccharide, namely ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (1), ?-L-Rha-(1?4)-?-D-GalA-(1?4)-?-D-GalA-OC3H7 (2), ?-D-GalA-(1?4)-?-D-GalA-(1?2)-?-L-Rha-OC3H7 (3), ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (4), and ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (5), which are relevant to the fragments of the rhamnogalacturonan of Nerium indicum, were concisely synthesized. The syntheses feature highly stereoselective formation of the ?-D-GalA-linkage with GalA N-phenyltrifluoroacetimidates as donors. PMID:23811084

Ma, Yuyong; Cao, Xin; Yu, Biao



Detoxification of Nerium indicum roots based on Indian system of medicine: phytochemical and toxicity evaluations.  


Indian system of medicine describes the usage of certain very toxic plant based drugs after performing a detoxification process (Shodhana samskara). Nerium indicum is traditionally used as a medicine though known to cause severe allergic symptoms, tachycardia and gastrointestinal effects leading to fatalities. In this study, the detoxification (shodhana) for Nerium indicum was scientifically validated based on phytochemical and toxicity profiles. Shodhana was performed according to traditional literature. HPTLC densitometric studies were performed for the pre- and post-shodhana powders followed by sub-acute toxicity evaluation in rats. Preparative TLC and LC-MS showed the reduction of oleandrin peak in the post-shodhana sample. Prominent features of cardiotoxicity including tachycardia were noted in the pre-shodhana Nerium treated animals along with mortality. However, no such toxicity was encountered in the post-shodhana Nerium treated animals. Hence, using the recommended detoxification (shodhana), the toxicity of an important medicinal plant was significantly nullified. Such studies provide a scientific support towards our traditional medicinal practices using modem analytical and experimental methodologies and may prove to be very useful in establishing standard scientific procedures for routine and safe use of traditional medicines. PMID:22125956

Banerjee, Aryamitra A; Vasu, Kamala K; Pancholi, Harit; Rajani, Mandapati; Nivsarkar, Manish A


Rapid detection of oleander poisoning by Digoxin III, a new Digoxin assay: impact on serum Digoxin measurement.  


We studied the potential for detecting oleander with a new immunoassay (Digoxin III, Abbott Laboratories, Abbott Park, IL) by comparing results with those from the fluorescence polarization immunoassay (FPIA) and Digoxin II assay (Abbott). In aliquots of drug-free serum pools supplemented with pure oleandrin or oleander extract, we observed apparent digoxin values using all 3 immunoassays, but values obtained by the Digoxin III were higher than obtained by the other assays. We also observed significant apparent digoxin values in vivo in serum samples of mice 1 and 2 hours after feeding oleander extract. The average half-life of digoxin-like factors was 1.1 hours. In a serum pool (prepared from patients taking digoxin) supplemented with oleander extract, the observed digoxin values were falsely lowered when measured by the Digoxin II but falsely elevated when measured by the Digoxin III and FPIA. Monitoring free digoxin using the Digoxin III cannot eliminate this interference. Digibind neutralized digoxin-like factors of oleander extract; the effect can be monitored by observing a significant reduction in apparent free digoxin levels in the presence of Digibind as measured in protein-free ultrafiltrate using the Digoxin III. The Digoxin III is highly sensitive for measuring oleander. PMID:18343781

Dasgupta, Amitava; Risin, Semyon A; Reyes, Meredith; Actor, Jeffrey K



Structural elucidation of a new arabinogalactan from the leaves of Nerium indicum  

Microsoft Academic Search

A polysaccharide fraction, NIB-2, was obtained from the 3% aqueous sodium carbonate extract of Nerium indicum leaves using anion-exchange chromatography and gel-permeation chromatography. It was found to be composed of rhamnose, arabinose, galactose, in the ratios of 1.0:10.4:4.4, along with 4% of galacturonic acid. The results of methylation analysis, periodate oxidation, partial acid hydrolysis, pectinase treatment, and 13C and 1H

Qun Dong; Ji-nian Fang



Control of common freshwater predatory fish, Channa punctatus, through Nerium indicum leaf extracts  

Microsoft Academic Search

The diethyl ether, chloroform, acetone and methanol extract of Nerium indicum leaf were evaluated for their piscicidal activity against common freshwater air breathing predatory fish Channa punctatus. The rank of order of toxicity (LC50) of the leaf extract was, diethyl ether extract (17.34 mg\\/l)>acetone (40.01 mg\\/l)>chloroform (40.61 mg\\/l)>and methanol (106.37 mg\\/l). There was a significant negative correlation between LC50 values

Sudhanshu Tiwari; Ajay Singh



A TaqMan-based real time PCR assay for specific detection and quantification of Xylella fastidiosa strains causing bacterial leaf scorch in oleander  

Technology Transfer Automated Retrieval System (TEKTRAN)

A TaqMan-based real-time PCR assay is developed for strains of X. fastidiosa causing oleander leaf scorch. The assay uses primers WG-OLS-F1 and WG-OLS-R1 and the fluorescent probe WG-OLS-P1, designed based on unique sequences present only in genomic sequence of oleander strain Ann1. The assay is spe...


Alterations in blood electrolytes of a freshwater catfish Heteropneustes fossilis in response to treatment with a botanical pesticide, Nerium indicum leaf extract.  


The present study aimed at investigating the effects of Nerium indicum leaf extract on the blood electrolytes of Heteropneustes fossilis for short- and long term. Fish were subjected to Nerium indicum leaf extract for short term (11.27 mg/L i.e. 0.8 of 96 h LC??) and long term (2.81 mg/L i.e. 0.2 of 96 h LC??). Fish were killed on each time intervals from control and experimental (Nerium indicum) groups after 24, 48, 72, and 96 h in short-term exposure and after 7, 14, 21, and 28 days in long-term experiment. Blood samples were analyzed for calcium and inorganic phosphate levels. Acute exposure of Nerium indicum leaf extract caused a progressive decrease in the serum calcium levels after 48 h in fish H. fossilis, which persists till the close of the experiment (96 h). The serum inorganic phosphate levels remain unaffected till 48 h in the Nerium indicum leaf extract-exposed fish. After 72 and 96 h, the levels exhibit a decrease. Chronic Nerium indicum leaf extract treatment provoked a decrease in serum calcium levels at day 14. This decrease continues till 28 days. The serum phosphate level of the Nerium indicum leaf extract-treated fish decreases on day 14 and 21. However, on day 28, the levels become close to the normal values. We conclude that Nerium indicum leaf extract exposure alters the blood electrolytes of the fish, thus causing physiological disturbances which might affect seriously the normal vital functions, growth rate, reproduction, and their survival in nature. PMID:21127966

Prasad, Maniram; Kumar, Abhishek; Mishra, Diwakar; Srivastav, Sunil K; Srivastav, Ajai K



New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities  

Microsoft Academic Search

To discover drug candidates with anti-angiogenesis activity for cancer therapeutics, three galactooligosaccharides (OJ1–OJ3) were prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill. Their structures were characterized using sugar analysis, methylation analysis, and both 1D and 2D NMR spectroscopy, complemented by mass spectrometry. They were hexasaccharide (OJ1), a pentasaccharide (OJ2), and an undecasaccharide (OJ3), which was a new

Ke Hu; Qin Liu; Shunchun Wang; Kan Ding




Microsoft Academic Search

Laboratory evaluations were made to asses the piscicidal activity of ethyl alcohol extract of Nerium indicum leaf against predatory fish Channa punctatus and their ultimate mode of action on fish metabolism. Toxicity experiments show there was significant negative correlation between LC values and exposure periods i.e. LC50 value decreased from 66.32 mg\\/L (24h) to 44.96 mg\\/L (96h). Biochemical studies show

Sudhanshu Tiwari; Ajay Singh


Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity  

Microsoft Academic Search

Cardiac glycosides from fresh leaves of Nerium indicum were evaluated for its molluscicidal activity against Pomacea canaliculata (golden apple snail: GAS) under laboratory conditions. The results showed that LC50 value of cardiac glycosides against GAS was time dependent and the LC50 value at 96h was as low as 3.71mg\\/L, which was comparable with that of metaldehyde at 72h (3.88mg\\/L). These

Lingpeng Dai; Wanxian Wang; Xinjiao Dong; Renyong Hu; Xuyang Nan



Chemical defence in chewing and sucking insect herbivores: Plant-derived cardenolides in the monarch butterfly and oleander aphid  

Microsoft Academic Search

Summary Cardenolide sequestration by a hemimetabolous aphid and a holometabolous butterfly from the neotropical milkweed,Asclepias curassavica L., is compared. The oleander aphid,Aphis nerii B. de F., sequestered a similarly narrow range of cardenolide concentrations to the monarch butterfly,Danaus plexippus (L.), from the wide range of concentrations available in leaves of A.curassavica. However, A.nerii sequestered significantly less cardenolide (269 µg\\/0.1 g)

Stephen B. Malcolm



The toxic activities of Arisaema erubescens and Nerium indicum mixed with Streptomycete against snails.  


The comparative molluscicidal activities of Arisaema erubescens tuber extracts and Nerium indicum leaf extracts mixed with Streptomycete violacerruber dilution (SD) against the snail Oncomlania hupensis and the responses of the isozymes, esterase (EST) and superoxide dismutase (SOD) to the A. erubescens extracts and the mixtures were investigated. The molluscicidal activity of A. erubescens water extracts mixed with S. violacerruber dilution was 4-5 times higher than a single A. erubescens or S. violacerruber dilution after 24-h exposure, and is also higher than that of N. indicum leaf water extracts mixed with S. violacerruber dilution. At the end of exposure to the N-butanol extracts of A. erubescens tubers (NEAT), the EST activity in snail liver decreased and some enzyme bands (EST 1 and EST 3 in exposure to NEAT) disappeared but the activities of SOD 1 increased. The effect was more obvious in mixture treatment than in single NEAT or SD treatment. The results indicated that molluscicidal activities of plant and microorganism could be more effective than single plant. The decline of the detoxic ability in snail liver cells could be the reason of the snail dying. PMID:21783953

Zhang, Yi; Ke, Wenshan; Yang, Jinglian; Ma, Anning; Yu, Zhensen



Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: A randomized controlled double blind study  

PubMed Central

Background Cardiac toxicity due to ingestion of oleander plant seeds in Sri Lanka and some other South Asian countries is very common. At present symptomatic oleander seed poisoning carries a mortality of 10% in Sri Lanka and treatment of yellow oleander poisoning is limited to gastric decontamination and atropine administration. The only proven effective antidote is digoxin antibodies but these are not available for routine use because of the high cost. The main objective of this study is to investigate the effectiveness of a new and inexpensive antidote for patients with life threatening arrhythmias due oleander poisoning. Method/design We set up a randomised double blind clinical trial to assess the effectiveness of Fructose 1, 6 diphosphate (FDP) in acute yellow oleander poisoning patients admitted to the adult medical wards of a tertiary hospital in Sri Lanka. Patients will be initially resuscitated following the national guidelines and eligible patients will be randomised to receive either FDP or an equal amount of normal saline. The primary outcome measure for this study is the sustained reversion to sinus rhythm with a heart rate greater than 50/min within 2 hours of completion of FDP/placebo bolus. Secondary outcomes include death, reversal of hyperkalaemia on the 6, 12, 18 and 24 hour samples and maintenance of sinus rhythm on the holter monitor. Analysis will be on intention-to-treat. Discussion This trial will provide information on the effectiveness of FDP in yellow oleander poisoning. If FDP is effective in cardiac glycoside toxicity, it would provide substantial benefit to the patients in rural Asia. The drug is inexpensive and thus could be made available at primary care hospitals if proven to be effective. Trial Registration Current Controlled trial ISRCTN71018309



New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities.  


To discover drug candidates with anti-angiogenesis activity for cancer therapeutics, three galactooligosaccharides (OJ1-OJ3) were prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill. Their structures were characterized using sugar analysis, methylation analysis, and both 1D and 2D NMR spectroscopy, complemented by mass spectrometry. They were hexasaccharide (OJ1), a pentasaccharide (OJ2), and an undecasaccharide (OJ3), which was a new linear galactan. Bioactivity testing in vitro showed that OJ2 and OJ3 significantly inhibited the HMEC-1 (human microvascular endothelial cell) cell tube formation. PMID:19054503

Hu, Ke; Liu, Qin; Wang, Shunchun; Ding, Kan



Selectivity of compounds isolated from the leaves of Nerium indicum Mill. on various human cancer cell lines.  


The leaves of Nerium indicum Mill. have been utilized traditionally to cure cancer. By Bioassay (BST) guided isolation method, six compounds were isolated from the CHCl3 extract of the leaves. Selectivity of these compounds (in 0.6-12,500 ng/ml) was tested on various human cancer (MCF7, EVSA-T, T47D, H226, IGROV, A498, WIDR, M19, HeLa) and normal (Vero) cells in vitro. Doxorubicin and cysplatin were used as positive controls. The result indicated that NiO2D (5alpha-oleandrin) possessed the best cytotoxic effect on HeLa cells (IC50, 8.38 x10(-6) mM) and NiO2C (16, 17-dehidrodeasetil-5alpha-oleandrin) on A498 cells (IC50, 1.43 x 10(-6) mM). Those two compounds were not cytotoxic to normal cell. PMID:19024965

Mae, S H W; Sofia, M; Bolhuis, R L H; Nooter, K; Oostrum, R G; Subagus, W; Ibnu, G G



Sex pheromone of the oleander scale, Aspidiotus nerii: Structural characterization and absolute configuration of an unusual functionalized cyclobutane  

PubMed Central

The sex pheromone emitted by the female oleander scale, Aspidiotus nerii (Homoptera, Diaspididae), has been isolated and characterized as (1R,2S)-cis-2-isopropenyl-1-(4?-methyl-4?-penten-1?-yl)cyclobutaneethanol acetate by using advanced MS and NMR spectroscopic methods, as well as a variety of microderivatization sequences. The structure has been confirmed by stereo- and enantioselective synthesis of the four possible stereoisomers. The absolute configuration has been determined by comparison of the activity of the cis (1S,2R) and (1R,2S) enantiomers with that exhibited by the natural material in greenhouse bioassays and field tests. The structure of this sesquiterpenoid pheromone is new in the coccids and in the pheromone field in general.

Einhorn, Jacques; Guerrero, Angel; Ducrot, Paul-Henri; Boyer, Francois-Didier; Gieselmann, Mary; Roelofs, Wendell



Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity.  


Cardiac glycosides from fresh leaves of Nerium indicum were evaluated for its molluscicidal activity against Pomacea canaliculata (golden apple snail: GAS) under laboratory conditions. The results showed that LC(50) value of cardiac glycosides against GAS was time dependent and the LC(50) value at 96 h was as low as 3.71 mg/L, which was comparable with that of metaldehyde at 72 h (3.88 mg/L). These results indicate that cardiac glycosides could be an effective molluscicide against GAS. The toxicological mechanism of cardiac glucosides on GAS was also evaluated through changes of selected biochemical parameters, including cholinesterase (ChE) and esterase (EST) activities, glycogen and protein contents in hepatopancreas tissues of GAS. Exposure to sublethal concentrations of cardiac glycosides, GAS showed lower activities of EST isozyme in the later stages of the exposure period as well as drastically decreased glycogen content, although total protein content was not affected at the end of 24 and 48 h followed by a significant depletion at the end of 72 and 96 h. The initial increase followed by a decline of ChE activity was also observed during the experiment. These results suggest that cardiac glycosides seriously impair normal physiological metabolism, resulting in fatal alterations in major biochemical constituents of hepatopancreas tissues of P. canaliculata. PMID:21843803

Dai, Lingpeng; Wang, Wanxian; Dong, Xinjiao; Hu, Renyong; Nan, Xuyang



Multilocus sequence typing of Xylella fastidiosa causing Pierce's disease and oleander leaf scorch in the United States.  


Using a modified multilocus sequence typing (MLST) scheme for the bacterial plant pathogen Xylella fastidiosa based on the same seven housekeeping genes employed in a previously published MLST, we studied the genetic diversity of two subspecies, X. fastidiosa subsp. fastidiosa and X. fastidiosa subsp. sandyi, which cause Pierce's disease and oleander leaf scorch, respectively. Typing of 85 U.S. isolates (plus one from northern Mexico) of X. fastidiosa subsp. fastidiosa from 15 different plant hosts and 21 isolates of X. fastidiosa subsp. sandyi from 4 different hosts in California and Texas supported their subspecific status. Analysis using the MLST genes plus one cell-surface gene showed no significant genetic differentiation based on geography or host plant within either subspecies. Two cases of homologous recombination (with X. fastidiosa subsp. multiplex, the third U.S. subspecies) were detected in X. fastidiosa subsp. fastidiosa. Excluding recombination, MLST site polymorphism in X. fastidiosa subsp. fastidiosa (0.048%) and X. fastidiosa subsp. sandyi (0.000%) was substantially lower than in X. fastidiosa subsp. multiplex (0.240%), consistent with the hypothesis that X. fastidiosa subspp. fastidiosa and sandyi were introduced into the United States (probably just prior to 1880 and 1980, respectively). Using whole-genome analysis, we showed that MLST is more effective at genetic discrimination at the specific and subspecific level than other typing methods applied to X. fastidiosa. Moreover, MLST is the only technique effective in detecting recombination. PMID:20465416

Yuan, Xiaoli; Morano, Lisa; Bromley, Robin; Spring-Pearson, Senanu; Stouthamer, Richard; Nunney, Leonard



Impact des produits de lessivage de feuilles mortes sur la teneur en oxygène de l'eau et sur la survie d'un gastéropode  

Microsoft Academic Search

The impact of the leaching of oleander, Nerium oleander, and willow, Salix pedicellata, leaves on the aquatic environment was investigated in the laboratory. The leaves were collected on the banks of a Moroccan stream, leachate polyphenols were analysed, and leachate toxic effects on the dominant gastropod species of the stream were investigated. The following factors were considered: leaf species, dry

H. Chergui; L. Haddy; M. Markaoui; E. Pattee



Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal.  

PubMed Central

Intentional self-poisonings with seeds from the yellow oleander tree (Thevetia peruviana) are widely reported. Activated charcoal has been suggested to benefit patients with yellow oleander poisoning by reducing absorption and/or facilitating elimination. Two recent randomised controlled trials (RCTs) assessing the efficacy of activated charcoal reported conflicting outcomes in terms of mortality. The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been assessed. This information may be useful for determining whether further studies are necessary. Serial blood samples were obtained from patients enrolled in a RCT assessing the relative efficacy of single dose (SDAC) and multiple doses (MDAC) of activated charcoal compared to no activated charcoal (NoAC). The concentration of Thevetia cardenolides was estimated using a digoxin immunoassay. The effect of activated charcoal on cardenolide pharmacokinetics was compared between treatment groups using the AUC24, the 24h Mean Residence Time (MRT24), and regression lines obtained from serial concentration points adjusted for exposure. Erratic and prolonged absorption patterns were noted in each patient group. The apparent terminal half-life was highly variable, with a median time of 42.9h. There was a reduction in MRT24 and the apparent terminal half-life estimated from linear regression in patients administered activated charcoal compared to the control group (NoAC). This effect was approximately equal in patients administered MDAC or SDAC. Activated charcoal appears to favourably influence the pharmacokinetic profile of Thevetia cardenolides in patients with acute self-poisoning, which may have clinical benefits. Given the conflicting clinical outcomes noted in previous RCTs, this mechanistic data supports the need for further studies to determine whether a subgroup of patients (eg. those presenting soon after poisoning) will benefit from activated charcoal.

Roberts, Darren M; Southcott, Emma; Potter, Julia M; Roberts, Michael S; Eddleston, Michael; Buckley, Nick A



Evaluation of selected plants for acute toxicosis in budgerigars.  


Pairs of budgerigars were given samples, by gavage, of plants considered potentially toxic to pet birds. Samples were prepared by flash-freezing and powdering fresh plant material in liquid nitrogen and resuspending the material in deionized water for administration. Of the 19 plants tested, only 6 induced clinical signs of illness; these plants included yew, oleander, clematis, avocado, black locust, and Virginia creeper (Taxus media, Nerium oleander, Clematis sp, Persea americana, Robinia pseudoacacia, Parthenocissus quinquefolio). PMID:1577644

Shropshire, C M; Stauber, E; Arai, M



The responses of stomata and leaf gas exchange to vapour pressure deficits and soil water content  

Microsoft Academic Search

The responses of photosynthesis, transpiration and leaf conductance to changes in vapour pressure deficit were followed in well-watered plants of the herbaceous species, Helianthus annuus, Helianthus nuttallii, Pisum sativum and Vigna unguiculata, and in the woody species having either sclerophyllous leaves, Arbutus unedo, Nerium oleander and Pistacia vera, or mesomorphic leaves, Corylus avellana, Gossypium hirsutum and Prunus dulcis. When the

Neil C. Turner; E.-D. Schulze; T. Gollan



Antiviral Activity of Some Plant Extracts on the Replication of Autographa californica Nuclear Polyhedrosis Virus  

Microsoft Academic Search

The effect of crude extracts, obtained from Aconitum nasutum, Daphne glomerata, Hypericum androsaemum, Laurus nobilis, Nerium oleander, Olea europaea, Prunus laurocerasus, Punica granatum, Rhododendron caucasicum, and Urtica dioica on the replication of Autographa californica nuclear polyhedrosis virus (AcNPV) grown in Spodoptera frugiperda cell culture were investigated by observing changes in cytophatic effects, progeny virus concentration and viral protein (polyhedrin) synthesis.




Atlas del Genoma del Cáncer

El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.


Use of plant extracts and biocontrol agents for the management of brown spot disease in rice  

Microsoft Academic Search

Fifty plant extracts, four oil cakes and eight antagonistic organisms were tested against Bipolaris oryzae (Cochliobolus miyabeanus), the causal agent of brown spot disease of rice. In vitro studies indicated that two leaf extracts, Nerium\\u000a oleander and Pithecolobium dulce exerted the higher percent inhibition to mycelial growth (77.4, 75.1%) and spore germination (80.3, 80.0%) of B. oryzae. Among the four oil

Sankarasubramanian Harish; Duraiswamy Saravanakumar; Ramalingam Radjacommare; E. G. Ebenezar; K. Seetharaman



Multiform biosynthetic pathway of syringyl lignin in angiosperms  

Microsoft Academic Search

To clarify the pathway for biosynthesis of sinapyl alcohol in angiosperms, tracer experiments using stable isotopes were performed on robinia (Robinia pseudoacacia L.), oleander (Nerium indicum Mill.), magnolia (Magnolia kobus DC.) and Arabidopsis thaliana (L.) Heynh. Precursors used in the experiment were 13C- and 2H (D)-labeled [8-13C, 3-OCD3]ferulic acid and [8-13C, 3,5-OCD3]sinapic acid. The incorporation of labeled precursor into lignin

Kazuchika Yamauchi; Seiichi Yasuda; Katsuyoshi Hamada; Yuji Tsutsumi; Kazuhiko Fukushima



The behavior of exogenous sinapic acid in the differentiating xylem of angiosperm  

Microsoft Academic Search

For many angiosperms, a 4-coumarate-CoA ligase (4CL; EC isozyme that exhibits activity with a sinapic acid substrate has not been detected in vitro. Therefore, the possible role of sinapic acid as a precursor of syringyl lignin has been questioned. To further examine this issue, heptadeutero sinapic acid &?-D, (-OCD2)2& were synthesized and fed to shoots of oleander (Nerium indicum

Kazuchika Yamauchi; Sciichi Yasuda; Kazuhiko Fukushima



Impact des produits de lessivage de feuilles mortes sur la teneur en oxygène de l'eau et sur la survie d'un gastéropode  

NASA Astrophysics Data System (ADS)

The impact of the leaching of oleander, Nerium oleander, and willow, Salix pedicellata, leaves on the aquatic environment was investigated in the laboratory. The leaves were collected on the banks of a Moroccan stream, leachate polyphenols were analysed, and leachate toxic effects on the dominant gastropod species of the stream were investigated. The following factors were considered: leaf species, dry or fresh state of the leaves, litter concentration, duration of leaching, temperature. Within the first 8-12 hrs of submersion, the litter of both species caused a great depletion of dissolved oxygen. Later, oxygen consumption decreased. Dry oleander leaves caused a greater drop in oxygen concentration than fresh oleander leaves. The opposite was observed in willow leaves, most clearly at 5 and 10°C. At higher temperatures (20 and 25°C), oxygen nearly totally disappeared under all conditions, leaving 0 to 2 mg.I -1 after 48 hours. Whether fresh or dry, oleander leaves always caused a greater oxygen depletion than willow leaves. Willow leaves contained more tannin-and non-tannin-polyphenols than oleander leaves, and their leaching released more of these compounds, especially in dry leaves. The leaching of both leaf species only had a toxic effect on the gastropods at the higher temperatures (20 and 25°C), thus suggesting that the toxic effect was mainly due to lack of oxygen in the water. At these temperatures, the toxic effect of dry leaves was greater than that of fresh leaves. Oleander proved more toxic than willow, presumably under the influence of both lack of oxygen and toxic heterosides.

Chergui, H.; Haddy, L.; Markaoui, M.; Pattee, E.


Políticas del sitio web

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.


La virtualización del cuerpo a través del \\  

Microsoft Academic Search

Hablar de un cuerpo virtualizado es hablar de su problematización y consecuente actualización, una de las principales consecuencias de este proceso de transfiguración del cuerpo estaría marcada por una adjudicación actualizada de un cambio. El cuerpo es simultáneamente un cuerpo-materia prima, modelo físico para la conversión óptico-iconográfica digital, y un cuerpo interfaz, que permite el acceso a la morfogénesis del

Eduardo Castro Pinzón; José Luis Troncoso



Dinámica del Desempeño Académico  

Microsoft Academic Search

Este trabajo se ocupa del progreso, luego del ingreso, de los estudiantes de la cohorte 2000 de la Facultad de Ciencias Económicas de la Universidad Nacional de La Plata. Si bien hay antecedentes de medición del rendimiento de los estudiantes de la Facultad y sus factores explicativos, se trata de estudios realizados en base a encuestas a alumnos regulares en

Luciano Di Gresia; Alberto Porto



Comparison of the suitability of two lichen species and one higher plant for monitoring airborne heavy metals.  


We compared the capacity to accumulate airborne heavy metals of two lichens (Flavoparmelia caperata and Parmotrema chinense) and one higher plant (Nerium oleander) at a very densely populated urban site near Naples. After 15, 45, 75, and 120 days of exposure at four sites with different levels of air pollution, equal portions of thalli and 20 leaves were collected, and four environmentally significant elements, Fe, Cu, Zn, and Pb, were measured by inductively coupled plasma analysis. To compare the accumulation rates of lichens and the vascular plant, we determined an index of relative accumulation rate of pollutants during time and the ratio between the concentrations of each element in exposed samples to that of control samples (exposed-to-control ratio). Our data indicate F. caperata as being the most suitable bioaccumulator, followed by P. chinense. N. oleander was also found to be a useful heavy metal biomonitor though not suitable as a bioaccumulator. PMID:19255863

Aprile, Giuseppa Grazia; Di Salvatore, Mina; Carratù, Giovanna; Mingo, Antonio; Carafa, Anna Maria



Les Brulures Chimiques Par Le Laurier Rose  

PubMed Central

Summary Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose de gravité différente. Cela doit aboutir à une information élargie de la population, ainsi qu'une réglementation stricte de sa commercialisation.

Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.



Naturally occurring cardiac glycosides.  


Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. Significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (Thevetia peruviana); oleander (Nerium oleander); wintersweet (Carissa spectabilis); bushman's poison (Carissa acokanthera); sea-mango (Cerbera manghas); and frangipani (Plumeria rubra); and in the milkweeds: redheaded cotton-bush (Asclepias curassavica); balloon cotton (Asclepias fruiticosa); king's crown (Calotropis procera); and rubber vine (Cryptostegia grandifolia). The venom gland of the cane toad (Bufo marinus) also contained large quantities of cardiac glycosides. The competitive immunoassay method permits the rapid screening of specimens that are suspected to contain cardiac glycosides. Awareness of the existence of these plant and animal toxins and their dangers allows them to be avoided and poisoning prevented. The method is also useful for the confirmation of the presence of cardiac glycosides in serum in cases of poisoning. PMID:3086679

Radford, D J; Gillies, A D; Hinds, J A; Duffy, P



A fatal case of oleandrin poisoning.  


The study presents a case of fatal poisoning with oleander leaves in an adult diabetic male. After repeated vomiting, and gastrointestinal distress the patient was admitted at the hospital with cardiac symptoms 1h after the ingestion. Urine samples were assayed immunochemically and by GC-MS for drugs of abuse and for general toxicological screen. Blood was analyzed for alcohol and volatiles by static head space GC-MS. Blood and oleander leaves were analyzed by LC-MS/MS for oleandrin and related compounds, the main cardiac glycosides of Nerium oleander. Oleandrin was detected by LC-MS/MS in the blood sample at a concentration of approximately 10 ng/ml. Another cardiac glycoside with pseudo-molecular ion of m/z 577, a likely structural isomer of oleandrin, was also detected in the blood and oleander leaves. However, by using the response as a function of concentration for oleandrin, this cardiac glycoside was roughly estimated at a concentration of approximately 10 ng/ml in the deceased blood. This would give a total fatal blood concentration of cardiac glycosides of about approximately 20 ng/ml in the deceased blood. PMID:18602779

Wasfi, Ibrahim A; Zorob, Omar; Al katheeri, Nawal A; Al Awadhi, Anwar M



Boletín del Instituto Nacional del Cáncer - 07-20-2010

El doctor Harold Varmus, acompañado de su esposa Constance Casey (centro), presta juramento como director del NCI ante la Secretaria del Departamento de Salud y Servicios Humanos, Kathleen Sebelius, el lunes 12 de julio. (Foto cortesía de Chris Smith) El 12 de julio, el doctor Harold Varmus prestó juramento ante la Secretaria del Departamento de Salud y Servicios Humanos de los Estados Unidos, Kathleen Sebelios, como el decimocuarto director del Instituto Nacional del Cáncer.


El pronóstico del cáncer

Hoja informativa sobre la predicción de resultados y recuperación de una enfermedad, y sobre cómo las estadísticas ayudan a los médicos a hacer una estimación del pronóstico de un paciente con cáncer.


Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

D'Antona, F.



Fisiopatología del estreñimiento  

Microsoft Academic Search

ResumenEl estreñimiento es un trastorno extremadamente frecuente en la infancia, responsable de hasta el 25% de todas las consultas gastroenterológicas pediátricas y el 3% de todas las consultas pediátricas ambulatorias. En el 90% de los casos el origen del trastorno es funcional y sólo en un 10% existe un problema orgánico subyacente. Entre las causas orgánicas corrientes del estreñimiento infantil

Peter J. Milla



Flammability of Some Ornamental Species in Wildland-Urban Interfaces in Southeastern France: Laboratory Assessment at Particle Level  

NASA Astrophysics Data System (ADS)

Assessment of the flammability of ornamental vegetation (particularly hedges) planted around houses is necessary in light of the increasing urbanization of the wildland-urban interfaces (WUIs) and the high fire occurrence in such areas. The structure and flammability of seven of the species most frequently planted as hedges in Provence (southeastern France) were studied at particle level. Spatial repartition of the different types of fuel particles within plants was assessed by means of the cube method. The leaf flammability was assessed using an epiradiator as a burning device, and measurements of foliar physical characteristics and gross heat of combustion (GHC) helped to explain the results of burning experiments. Co-inertia analysis revealed that species with thin leaves were quick to ignite ( Pyracantha coccinea, Phyllostachys sp.) and species with high leaf GHC burned the longest ( Pittosporum tobira, Nerium oleander). Species presenting high ignitability ( Photinia fraseri, Phyllostachys sp. and Pyracantha coccinea) were characterized by high foliar surface area-to-volume ratio, and species presenting lower ignitability were characterized by high GHC ( Pittosporum tobira, Nerium oleander, Cupressus sempervirens). Hierarchical cluster analysis of the flammability variables (ignition frequency, time-to-ignition and flaming duration) categorized the relative flammability of the seven species (including dead Cupressus sempervirens) in five clusters of species from poorly flammable ( Pittosporum tobira) to extremely flammable (dead Cupressus sempervirens).This study provides useful information for reducing fire risk in WUIs in the study area.

Ganteaume, Anne; Jappiot, Marielle; Lampin, Corinne; Guijarro, Mercedes; Hernando, Carmen



Unripe red fruits may be aposematic  

PubMed Central

The unripe fruits of certain species are red. Some of these species disperse their seeds by wind (Nerium oleander, Anabasis articulata), others by adhering to animals with their spines (Emex spinosa) or prickles (Hedysarum spinosissimum). Certainly neither type uses red coloration as advertisement to attract the seed dispersing agents. Fleshy-fruited species (Rhamnus alaternus, Rubus sanguineus and Pistacia sp.), which disperse their seeds via frugivores, change fruit color from green to red while still unripe and then to black or dark blue upon ripening. The red color does not seem to function primarily in dispersal (unless red fruits form advertisement flags when there are already black ripe fruits on the plant) because the red unripe fruits of these species are poisonous, spiny, or unpalatable. The unripe red fruits of Nerium oleander are very poisonous, those of Rhamnus alaternus and Anabasis articulata are moderately poisonous, those of Rubus sanguineus are very sour, those of Pistacia sp. contain unpalatable resin and those of Emex spinosa and Hedysarum spinosissimum are prickly. We propose that these unripe red fruits are aposematic, protecting them from herbivory before seed maturation.

Ne'eman, Gidi; Izhaki, Ido



Unripe red fruits may be aposematic.  


The unripe fruits of certain species are red. Some of these species disperse their seeds by wind (Nerium oleander, Anabasis articulata), others by adhering to animals with their spines (Emex spinosa) or prickles (Hedysarum spinosissimum). Certainly neither type uses red coloration as advertisement to attract the seed dispersing agents. Fleshy-fruited species (Rhamnus alaternus, Rubus sanguineus and Pistacia sp.), which disperse their seeds via frugivores, change fruit color from green to red while still unripe and then to black or dark blue upon ripening. The red color does not seem to function primarily in dispersal (unless red fruits form advertisement flags when there are already black ripe fruits on the plant) because the red unripe fruits of these species are poisonous, spiny, or unpalatable. The unripe red fruits of Nerium oleander are very poisonous, those of Rhamnus alaternus and Anabasis articulata are moderately poisonous, those of Rubus sanguineus are very sour, those of Pistacia sp. contain unpalatable resin and those of Emex spinosa and Hedysarum spinosissimum are prickly. We propose that these unripe red fruits are aposematic, protecting them from herbivory before seed maturation. PMID:19847110

Lev-Yadun, Simcha; Ne'eman, Gidi; Izhaki, Ido



Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)

En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science Translational Medicine sobre “La integración del control del cáncer en la salud mundial" (Integrating Cancer Control into Global Health).


Multiform biosynthetic pathway of syringyl lignin in angiosperms.  


To clarify the pathway for biosynthesis of sinapyl alcohol in angiosperms, tracer experiments using stable isotopes were performed on robinia ( Robinia pseudoacacia L.), oleander ( Nerium indicum Mill.), magnolia ( Magnolia kobus DC.) and Arabidopsis thaliana (L.) Heynh. Precursors used in the experiment were (13)C- and (2)H ( D)-labeled [8-(13)C, 3-OCD(3)]ferulic acid and [8-(13)C, 3,5-OCD(3)]sinapic acid. The incorporation of labeled precursor into lignin was confirmed by gas chromatography-mass spectrometry of the products of derivatization followed by reductive cleavage. Crude extracts of differentiating xylem or stems from these plants were also assayed for 4-coumarate-CoA ligase (4CL; EC activity using sinapic acid and ferulic acid as substrates. In robinia and oleander, 4CL activity toward sinapic acid was detected, and labeled sinapic acids were incorporated into syringyl lignin. These results indicate that robinia and oleander have a pathway that produces sinapyl alcohol from sinapic acid via sinapoyl-CoA. By contrast, in magnolia and Arabidopsis, 4CL activity toward sinapic acid could not be detected, and labeled sinapic acid was not incorporated into lignin. These results suggest that syringyl lignin biosynthesis in angiosperms operates via multiple pathways that depend on the species. PMID:12520342

Yamauchi, Kazuchika; Yasuda, Seiichi; Hamada, Katsuyoshi; Tsutsumi, Yuji; Fukushima, Kazuhiko



Selection of woody species for wastewater enhancement and restoration of riparian woodlands.  


Growth and nutrient uptake of seven tree species were evaluated with the goal of selecting the species that can be used for wastewater enhancement by dendro-purification, or green tree filtering, and for restoration of riparian woodlands. Trees were grown in pots with an inert mixture of perlite and vermiculite and irrigated with either nutrient solution or treated wastewater We measured the effects of species and irrigation water on biomass and nutrient content of leaves, stems and roots. For most of the species, treated wastewater had a positive effect on final biomass and above ground: below ground ratio compared to that of nutrient solution. However, growth of Cupressus sempervirens and Populus nigra were inhibited by water sodium concentration. Nerium oleander, Tamarix africana and Vitex agnus-castus were the species with the greatest final biomass. Pistacia terebinthus had the highest nitrogen and phosphorus content in leaves, stems and roots, while N. oleander and V. agnus-castus showed the best potassium accumulation. In general, P. terebinthus, N. oleander, T. africana and V. agnus-castus were the best qualified species for purification of wastewater. PMID:18972692

Adrover, M; Forss, A L; Ramon, G; Vadell, J; Moya, G; Taberner, A Martinez



Phase Transitions in Thylakoid Polar Lipids of Chilling-Sensitive Plants  

PubMed Central

The phase behavior of thylakoid polar lipids from plants sensitive to chilling injury was investigated by calorimetry, electron spin resonance spectroscopy of spin labels, and fluorescence intensity after labeling with trans-parinaric acid. The plants used were oleander (Nerium oleander), mung bean (Vigna radiata L. var Mungo), and tomato (Lycopersicon esculentum cv Grosse Lisse). For all plants the initiation temperature for the calorimetric exotherm was coincident (±1°C) with the transition determined by the increase in the temperature coefficient of spin label motion and fluorescence intensity of trans-parinaric acid. For oleander plants, grown at 45°C, the transition was at 7°C while for plants from the same clone, grown at 20°C, it was at ?2°C. For mung bean and tomato the transition was between 9 and 12°C. The similarity in the transition detected by spin labeling and fluorescence intensity suggest that spin labels, like the fluorescent label trans-parinaric acid, preferentially partition into domains of ordered lipid. The coincidence of the temperature for initiation of the transition, determined by the three techniques, shows that each is a valid method of assessing a phase transition in membrane polar lipids.

Raison, John K.; Orr, Glenda R.



Boletín del Instituto Nacional del Cáncer - 02-02-2010

En un estudio clínico en fase inicial que probó una vacuna terapéutica en pacientes con leucemia mieloide crónica (LMC) que tomaban el fármaco imatinib (Gleevec), no se pudieron detectar células cancerosas en 7 de los 19 participantes por un tiempo promedio de 22 meses. Los resultados del estudio fueron publicados en el número del 1º de enero de la revista Clinical Cancer Research.


Cáncer de cuello del útero o uterino

Información acerca del cáncer de cérvix (cervical o cuello uterino), lo cual incluye temas como tratamiento, prevención, causas, factores de riesgo, exámenes selectivos de detección, estudios clínicos y estadísticas del Instituto Nacional del Cáncer.



Microsoft Academic Search

En este trabajo se aborda el posible origen evolutivo del derecho como una consecuencia del desarrollo social de nuestra especie. Otras especies con sistemas sociales similares presentan varias reglas para la convivencia en grupo. Algunas de estas reglas son comunes en todas las especies con comportamiento social. El desarrollo de la sociobiología en las últimas décadas es una herramienta importante

Axel P. Retana-Salazar


Assessing and ranking the flammability of some ornamental plant species to select firewise plants for landscaping in WUI (SE France).  

NASA Astrophysics Data System (ADS)

The increasing urbanization of Wildland-Urban Interfaces (WUI) as well as the high fire occurrence in these areas requires the assessment and the ranking of the flammability of the ornamental vegetation surrounding houses especially that planted in hedges. Thus, the flammability of seven species, among those most frequently planted in hedges in Provence (South-Eastern France), were studied at particle level and at dead surface fuel level (litters) under laboratory conditions. The flammability parameters (ignition frequency, time-to-ignition, flaming duration) of the very fine particles (live leaves and particles <2 mm in diameter) were measured using an epiradiator as burning device. The flammability parameters (ignition frequency, time-to-ignition, flaming duration and initial flame propagation) of the undisturbed litter samples were recorded during burning experiments performed on fire bench. Burning experiments using the epiradiator showed that live leaves of Phyllostachys sp., Photinia frasei and Prunus laurocerasus had the shortest time-to-ignition and the highest ignition frequency and flaming duration whereas Pittosporum tobira and Nerium oleander were the longest to ignite with a low frequency. Phyllostachys sp. and Nerium oleander litters were the shortest to ignite while Prunus laurocerasus litter had the lowest bulk density and long time-to-ignition, but high flame propagation. Photinia fraseri litter ignited frequently and had a high flame spread while Pittosporum tobira litter ignited the least frequently and for the shortest duration. Cupressus sempervirens litter had the highest bulk density and the longest flaming duration but the lowest flame propagation. Pyracantha coccinea litter was the longest to ignite and flame propagation was low but lasted a long time. Hierarchical cluster analysis performed on the flammability parameters of live leaves and of litters ranked the seven species in four distinct clusters from the most flammable (Prunus laurocerasus and Pyracantha coccinea) to the least flammable (Pittosporum tobira and Nerium oleander); the other species displaying two groups of intermediate flammabilities (Phyllostachys sp.- Photinia fraseri and Cupressus sempervirens ). The species with highly flammable characteristics should not be used in hedges planted in WUIs in South-Eastern France.

Ganteaume, A.; Jappiot, M.; Lampin, C.



Alberto del Pozo  

NSDL National Science Digital Library

The Cuban Heritage Collection of the University of Miami Libraries was a recipient of 17 original illustrations by Alberto del Pozo in 1998 from the Campilli family. "The Oricha Collection" is their gift, and it contains illustrations in pen, crayon, and ink and the collection "pays homage to the primary gods and goddesses that comprise the Afro-Cuban religion of Santer'a." The "Introduction" near the top of the page, is a good place for visitors to start learning about Pozo, who was a Parson's School of Design-trained, Cuban artist who died at the age of 47. The "Biographical Sketch" is worth looking at as well. Examples of his colorful, heavily patterned and symbolism-intensive drawings of Santeria gods and goddesses can be found in the link "Gallery". The description of each drawing is given in English and Spanish. Finally, visitors interested in more information on the Santeria, can look at the "Further Readings" link for authoritative books on the subject.


Sulla struttura eletronica del nitrobenzolo  

Microsoft Academic Search

Riassunto  È presentato un calcolo di alcune grandezze fisiche del nitrobenzolo mediante il metodo M.O. con una ragionevole scelta dei\\u000a parametri necessari. Per il momento elettrico, la frequenza del primo massimo di assorbimento nell’ultravioletto, le densità\\u000a elettroniche, gli ordini di legame, gli indici di valenza libera e l’energia di risonanza si ottengono valori in ottimo accordo\\u000a con le previsioni. Anche il

M. Simonetta; A. Vaciago



Plant-derived wildlife repellents  

US Patent & Trademark Office Database

Products from the plant species Nerium oleander and, Urginea maritima, are prepared and tested as wildlife repellents comparing them with digitalis products. Chemical compounds derived from these plants including oleandrin, oleandrigenin, scillirosidin, digitoxigenin and digoxigenin are shown to cause nausea and emesis at low doses in pigeons and to repel, mice, rats, gophers, meadow voles and mountain beavers. After ingestion these animals quickly learn to avoid targets treated with the plant-derived repellents. When the remembrance of a treated food or other target lasts for an extended period of time it can be termed an aversion conditioning agent. Such products can be used for the protection of other plants, seeds, buildings, structures, communication cables and animals exposed to wildlife.

Verbiscar; Anthony J. (Sierra Madre, CA)




Microsoft Academic Search

RESUMEN Datos diarios de temperaturas máximas y mínimas del aire fueron usados para determinar las unidades calor, que sirvieron como referencia para definir las principales etapas fenológicas en seis tipos diferentes de chile (Capsicum annuum). Las unidades calor sirvieron para inferir el período de mayor requerimiento de nutrimentos, así como la relación con la sintomatología de las enfermedades más importantes

Salvador Montes Hernández; Elena Heredia García; J. Alfonso; Aguirre Gómez


Space as a Metafictional Marker: Borges' 'Tema del traidor y del héroe' and Bertolucci's Strategia del ragno  

Microsoft Academic Search

:In this study, I analyse space as a key marker of the metafictional characteristic of Jorge Luis Borges' story 'Tema del traidor y del héroe' (in Ficciones) and Bernardo Bertolucci's film Strategia del ragno. I contend that the presentation of space – this understudied 'other' with regard to time in criticism of Borges – is a major aspect of the

Ilka Kressner


Space as a Metafictional Marker: Borges' 'Tema del traidor y del héroe' and Bertolucci's Strategia del ragno  

Microsoft Academic Search

In this study, I analyse space as a key marker of the metafictional characteristic of Jorge Luis Borges' story 'Tema del traidor y del héroe' (in Ficciones) and Bernardo Bertolucci's film Strategia del ragno. I contend that the presentation of space – this understudied 'other' with regard to time in criticism of Borges – is a major aspect of the

Ilka Kressner


Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina  

Microsoft Academic Search

Riassunto Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Michele Lunetta; Giuseppe Calcagno; Luciano Motta; Turiddu Lombardo



Marina Del Rey Subregional Plan.  

National Technical Information Service (NTIS)

The Marina del Ray Subregional Plan was created for submission to the South Coast Regional Commission of the California Coastal Zone Conservation Commission. Since there are not, as yet, any other coastal subregional plans to use as examples, this plan fo...

M. McCoy C. Walecka



Del Mar College GIS Program  

NSDL National Science Digital Library

Del Mar College offers a comprehensive geospatial program with certificates and Associates degrees in GIS. This site includes description of the program and courses, along with further contact information. By clicking on the link for "Geographic Information Systems" you may download a PDF with information about the program.



Del Pezzo surfaces with Du Val singularities  

NASA Astrophysics Data System (ADS)

In this paper we study the problem of existence of orbifold Kaehler-Einstein metrics on del Pezzo surfaces of degree 1 with Du Val singular points. Moreover we compute global log canonical thresholds of del Pezzo surfaces of degree 1 with Du Val singularities and of del Pezzo surfaces of Picard rank 1 with Du Val singularities.

Kosta, Dimitra



Política de comentarios del NCI

Animamos a los usuarios a compartir sus ideas relacionadas con los temas en discusión en las secciones o foros determinados para tal fin en este sitio web u otros sitios administrados por el Instituto Nacional del Cáncer. Revisamos y publicamos los comentarios de acuerdo a la política indicada a continuación. Nos reservamos el derecho, a nuestra completa discreción, a no publicar o eliminar comentarios que no están de acuerdo con nuestra política.


DelPhi: a comprehensive suite for DelPhi software and associated resources  

PubMed Central

Background Accurate modeling of electrostatic potential and corresponding energies becomes increasingly important for understanding properties of biological macromolecules and their complexes. However, this is not an easy task due to the irregular shape of biological entities and the presence of water and mobile ions. Results Here we report a comprehensive suite for the well-known Poisson-Boltzmann solver, DelPhi, enriched with additional features to facilitate DelPhi usage. The suite allows for easy download of both DelPhi executable files and source code along with a makefile for local installations. The users can obtain the DelPhi manual and parameter files required for the corresponding investigation. Non-experienced researchers can download examples containing all necessary data to carry out DelPhi runs on a set of selected examples illustrating various DelPhi features and demonstrating DelPhi’s accuracy against analytical solutions. Conclusions DelPhi suite offers not only the DelPhi executable and sources files, examples and parameter files, but also provides links to third party developed resources either utilizing DelPhi or providing plugins for DelPhi. In addition, the users and developers are offered a forum to share ideas, resolve issues, report bugs and seek help with respect to the DelPhi package. The resource is available free of charge for academic users from URL:



Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.


Los dilemas del desarrollo territorial: repercusiones del zapatismo en la Selva Lacandona de Chiapas1  

Microsoft Academic Search

Este artículo discute los dilemas del desarrollo territorial en la Selva Lacandona. En particular analiza las relaciones entre movimientos sociales, nuevas formas de gobernanza ambiental y desarrollo en esta región del estado de Chiapas, en México. Con base en el llamado enfoque territorial del desarrollo rural (Schejtman y Berdegué, 2004), planteamos que en el contexto actual de globalización, para lograr

Luis Reygadas


Aristocracia fantástica: los moderados y la poética del gobierno representativo  

Microsoft Academic Search

La mayor parte de los ideólogos del moderantismo tras la implantación del régimen liberal fueron destacados teóricos de la estética que contribuyeron a fijar el canon del romanticismo en España. Este artículo investiga la influencia de las reflexiones estéticas de autores como Alberto Lista, Nicomedes Pastor Díaz y Alcalá Galiano en su teoría del gobierno representativo. El asunto de fondo

Pablo Sánchez León



33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation...LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey...



33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 2009-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation...LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey...



Dust formation in Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the result of the IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. JHKLM photometry was carried out with 125-cm telescope using a InSb-photometer on:

Shenavrin, V. I.; Taranova, O. G.; Tatarnikov, A. M.



Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur  

NASA Astrophysics Data System (ADS)

Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( ? = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.



Precio del agua y relocalización del recurso en la economía andaluza. Una aproximación desde un modelo de equilibrio general aplicado  

Microsoft Academic Search

El objetivo de este trabajo consiste en analizar los efectos que tendría un incremento en la tarifa del agua del sector agrario sobre la conservación del recurso, la eficiencia en el consumo y la posible relocalización del mismo entre los diferentes sectores productivos. La política tarifaria se aplicará sobre el sector agrario debido, por un lado, al excesivo consumo de

M. Alejandro Cardenete; G. J. D. Hewings; E. Velázquez



Declaración del Instituto Nacional del Cáncer sobre los exámenes selectivos de detección de cáncer de seno

El Instituto Nacional del Cáncer (NCI) agradece la cuidadosa revisión y análisis que ha hecho la Brigada de Servicios Preventivos de los Estados Unidos de la evidencia con respecto a los exámenes de detección de cáncer de seno para mujeres que tienen un riesgo del promedio.Preguntas y Repuestas


Boletín del Instituto Nacional del Cáncer - 3 de enero de 2012

Dra. Rachel Ballard-Barbash Nuevos indicios del papel de la obesidad en el cáncer A medida que ha aumentado la prevalencia de la obesidad alrededor del mundo, se ha incrementado también la preocupación sobre sus consecuencias en la salud pública. Los índices de obesidad se han más que duplicado desde 1980, según la Organización Mundial de la Salud.


Preguntas y respuestas acerca del Estudio del Tamoxifeno y Raloxifeno (STAR)

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés) es un estudio clínico (un estudio de investigación conducido con voluntarios) diseñado para ver cómo el medicamento raloxifeno (Evista®) se compara con el medicamento tamoxifeno (Nolvadex®) en reducir la incidencia de cáncer del seno en las mujeres con alto riesgo de desarrollar la enfermedad.


Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

|This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy



Evaluación de elementos estructurales del hábitat del borrego cimarrón en la Sierra del Mechudo, Baja California Sur, México  

Microsoft Academic Search

Habitat lost and fragmentation can result in an isolated and local extinction risk for small populations like Ovis canadensis weemsi Goldman, 1937, in Sierra del Mechudo, Baja California Sur, Mexico. That is why it is important to evaluate the relationship between species and their habitat in order to design management and conservation plans. The object of this study was to

Sergio Alvarez-Cárdenas; Patricia Galina-Tessaro; Sara Díaz-Castro; Israel Guerrero-Cárdenas; Aradit Castellanos-Vera; Erika Mesa-Zavala


Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We continued to follow Nova Del 2013 during the period from 31.15 August 2013 UT through 25.18 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) is used as the standard star.

Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.



Andrea del Sarto rehabilitated: a psychoanalytic emendation.  


Ernest Jones's "The Influence of Andrea del Sarto's Wife on His Art" (1913) is an early example of psychoanalysis applied to the study of a prominent painter. Greatly influenced by Freud's Leonardo da Vinci and a Memory of His Childhood, Jones gave excessive credence to Vasari's highly prejudicial account of the life of del Sarto, on which the study relied heavily. Jones attempted to account psychologically for the circumstance that del Sarto, though highly skilled and "faultless," was not the equal of the three preeminent masters of the Italian High Renaissance: Leonardo, Michelangelo, and Raphael. Jones's uncritical acceptance of the Vasari biography encouraged him to view Sarto's assumed deficiency as the result of excessive attachment to his wife, a pathological uxoriousness. A contemporary psychoanalytic perspective, with its emphasis on the emotive response of the analyst, requires us to pay attention to the evocative nature of the work of the artist, an approach Jones neglected. In an examination of several paintings, the artist's sensitivity to the position of the spectator is explored, as is the interest in involving the viewer spatially and emotionally. An appreciation for the viewer's position is consistent with a capacity for using projected internal objects for creative purposes. The presence of this capacity suggests a revised view of del Sarto's contribution to art and of his relationship with his wife. PMID:12580329

Trosman, Harry



Quina és la funció del gen clonat?  

Microsoft Academic Search

Presentem una activitat didàctica complementària per a alumnes de segon de batxillerat. A partir d’una seqüència de nucleòtids del genoma de Paenibacillus barcinonensis determinem la regió codificant d’un gen, la proteïna corresponent i la seva funció. Com a annex s’inclou el guió per a l’alumnat.

Margarita Soriano; Francisca Guerola




Microsoft Academic Search

Es un hecho fácilmente constatable que la actividad económica en gene- ral e industrial en particular se localiza de forma desigual a lo largo de la geografía española. El presente trabajo plantea un modelo que tiene como objetivo analizar la incidencia de las economías externas en la dis- tribución territorial del empleo de los distintos sectores industriales. El modelo incorpora




Boletín del Instituto Nacional del Cáncer - 27 de marzo de 2012

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Els títols dels films de Quentin Tarantino : una perspectiva multilingüe  

Microsoft Academic Search

Els títols de films en llengua anglesa són, avui dia, textos (o paratextos) de gran importància cultural en les societats occidentals. En aquest article ens ocupem de dues qüestions: (1) del fenomen —força popular— de la traducció dels títols de pel·lícules en llengua anglesa que arriben al nostres cinemes; repassem les variades tipologies emprades per analitzar les traduccions dels títols

José Santaemilia; Betlem Soler



Análisis del comportamiento estructural de la basílica del Pilar de Zaragoza  

Microsoft Academic Search

En el artículo se presentan los trabajos de desarrollo y validación de un conjunto de modelos estructurales\\u000ade la basílica del Pilar de Zaragoza planteados con el objetivo de aproximar el estado estructural actual del\\u000atemplo y su nivel de seguridad. Los modelos numéricos se han formulado aplicando el MEF en teoría lineal\\u000ay no lineal, incluyendo el proceso constructivo

Luis E. Romera; Santiago Hernández; José Manuel Reinosa



Boletín del Instituto Nacional del Cáncer - 31 de enero de 2012

Dr. Nils Daulaire Salud mundial a través de la colaboración y el liderazgo Para conmemorar el Día Mundial del Cáncer que tuvo lugar el 4 febrero, el doctor Nils Daulaire, director de la Oficina de Asuntos Internacionales del Departamento de Salud y Servicios Humanos de los Estados Unidos habla sobre las razones por las cuales los Estados Unidos deben participar en iniciativas para mejorar la salud mundial.


Estudio para la prevención del cáncer necesita voluntarias: El Estudio del Tamoxifeno y Raloxifeno (STAR) se realiza en Norteamérica

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés), uno de los estudios más importantes realizados para la prevención del cáncer del seno, está ahora reclutando voluntarias en más de 400 centros en los Estados Unidos, Puerto Rico y Canadá.


Evaporación dinámica del cinturón de asteroides original  

NASA Astrophysics Data System (ADS)

Hemos integrado numéricamente un enjambre de 3000 partículas en la región del cinturón de asteroides, sujetas a las perturbaciones gravitatorias de Júpiter y Saturno. Al cabo de 107 años, se han formado ya todos los gaps de Kirkwood observados en el cinturón actual. El grupo en la resonancia 3/2 es, aunque en menor grado, también visible. Los tiempos de Lyapunov computados para los asteroides sobrevivientes, nos ha permitido encontrar la fracción de ellos que es capaz de sobrevivir por toda la edad del sistema solar, merced a la aplicacion de la relación empírica que vincula dichos tiempos al tiempo en el cual se manifiestan grandes transiciones orbitales. La fracción de supervivientes es de aproximadamente 1/100. El resto de la masa faltante en el cinturón, es atribuible a colisiones catastróficas con cometas en etapas primordiales.

Brunini, A.


Applicability of leachates originating from solid-waste landfills for irrigation in landfill restoration projects.  


Since, landfill areas are still the most widely used solid waste disposal method across the world, leachate generated from landfills should be given importance. Leachate of landfills exerts environmental risks mostly on surface and groundwater with its high pollutant content, which may cause unbearable water quality. This leads to the obligation for decontamination and remediation program to be taken into progress for the landfill area. Among a number of alternatives to cope with leachate, one is to employ the technology of phytoremediation. The main objective of this study was to determine the N accumulation ratios and the effects of landfill leachate in diluted proportions of chosen ratios (as 1/1, 1/2, 1/4, 0), on the growth and development of Cynodon dactylon, Stenotaphrum secundatum, Paspalum notatum, Pennisetum clandestinum, Mentha piperita, Rosmarinus officinalis, Nerium oleander, Pelargonium peltatum and Kochia scoparia species. In order to simulate the actual conditions of the landfill, soil covering the landfill is taken and used as medium for the trials. The study showed that S. secundatum, K. scoparia and N. oleander species had an impressive survival rate of 100%, being irrigated with pure leachate, while the others' survival rates were between 0 to 35% under the same conditions. As expected, application of leachate to the plants caused an increase in the accumulation of N, in the upper parts of all plants except P. peltatum. The highest N content increase was observed at S. Secundatum set, accumulating 3.70 times higher than its control set, whereas P. clandestinum value was 3.41 times of its control set. PMID:19295082

Erdogan, Reyhan; Zaimoglu, Zeynep; Sucu, M Yavuz; Budak, Fuat; Kekec, Secil



Particle pollution - An environmental magnetism study using biocollectors located in northern Portugal  

NASA Astrophysics Data System (ADS)

In this study the magnetic properties of tree leaves were measured in order to compare their capability to accumulate particles, to establish the relationship between magnetic properties and chemical data and to assess the particle pollution in selected locations in the cities of Braga, Porto, Valongo and Trancoso-Reboleiro, northern Portugal. In Porto, Braga and Valongo, leaves from the evergreen Nerium oleander were sampled each month during a year. N. oleander and deciduous Quercus spp. and Platanus spp. samples were collected in the same site in Porto, in order to determine the ability of these different leaves to accumulate particles. The leaves of deciduous Tilia spp. were collected in Porto and in a rural area (Trancoso-Reboleiro) so that a comparison could be established between them. The results indicated a contrast between the urban and the rural areas. The highest concentration of magnetic particles was found in the sampling site of Valongo and the lowest concentration in the sampling site of Trancoso-Reboleiro. In Porto, the results have shown that the Quercus leaves possessed the highest capability to accumulate particles even though it is a deciduous species. The IRM acquisition curves and the S-300 ratios found in the samples of the urban areas indicated the presence of magnetite-like structures. SIRM/? ratio revealed particles whose dimensions ranged between 5 ?m and 8 ?m in urban areas. The chemical elements copper and iron have a significant positive correlation with ? and SIRM, which highlights the use of magnetic properties as a proxy for the concentration of these metals in atmospheric dust. The magnetic properties were interpreted taking into consideration the rainfall peaks and then compared with the PM10 concentration levels monitored in an air quality station in Porto. Our data corroborated that magnetic properties provide a fast and inexpensive tool to evaluate long-term urban pollution from anthropogenic origin, especially heavy traffic.

Sant'Ovaia, Helena; Lacerda, Maria João; Gomes, Celeste



El valor de uso recreativo del Parque Natural de L'Albufera a través del método indirecto del coste de viaje  

Microsoft Academic Search

La valoración económica de bienes que carecen de mercado, como son los espacios naturales protegidos, proporcionan una valiosa información que puede ser utilizada en el análisis coste-beneficio como fundamento de las decisiones públicas que afectan a la calidad del medio ambiente. En este trabajo se aplica el método indirecto del coste de viaje individual para obtener el valor de uso




A Description of Del Mod and Its Final Evaluation, Final Report, Volume I.  

ERIC Educational Resources Information Center

This monograph presents an overview of five Del Mod System final reports, comments by the project director, financial structure of the Del Mod System, and descriptions of Del Mod Projects. The Del Mod System was concerned with changing the science and mathematics education programs in the state of Delaware. Between 1970 and 1976, Del Mod conducted…

Purnell, Charlotte H.; Bolig, John R.


An evening at "La Clinica del Pueblo".  


This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program. PMID:12281149

Shefsky, M L



UBVJHKLM photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the results of the optical and IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. UBV photometry was carried out with 60-cm Zeiss telescope using a photoelectric photometer on August 15.94 UT: U=4.54+/-0.02, B=5.07+/-0.01, V=5.05+/-0.01; on August 16.80 UT: U=4.54+/-0.01, B=4.85+/-0.02, V=4.68+/-0.01; on August 16.86 UT: U=4.66+/-0.01, B=4.92+/-0.01, V=4.73+/-0.01.

Burlak, A. M.; Shenavrin, I. V.; Tatarnikov, M. A.; Tatarnikova, A. A.



Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report RIJHKLM photometry of Nova Del 2013 taken on August 28.13 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) was used as the standard star. On this date we find: R = 5.6 +/- 0.1, I = 5.2 +/- 0.1, J = 4.5 +/- 0.1, H = 4.7 +/- 0.1, K = 4.7 +/- 0.1, L = 3.3 +/- 0.2, M = +1.8 +/- 0.3.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.



The paleontological site in the Sierra del Chaparral (Villaluenga del Rosario, Cádiz-Spain)  

Microsoft Academic Search

This article outlines the results obtained during the first study of the Chaparral site (Villaluenga del Rosario, Cádiz, Spain) situated in the karst area of the Sierra de Grazalema. The varied macro- and micro-vertebrate fauna include carnivore, herbivores and rodents, as well as reptiles and amphibians, suggesting an Early Pleistocene age. The taphonomic study of the fauna discovered on the

Francisco Giles Pacheco; Antonio Santiago; José María Gutiérrez; Juan Manuel López-García; Hugues-Alexandre Blain; Gloria Cuenca-Bescós; Jan van der Made; Isabel Cáceres; Nuria García



Microsoft Academic Search

Con este trabajo pretendemos acercarnos al Carnaval de Andalucía occidental a partir de su recuperación durante la Transición y los gobiernos socialistas en la década de los años ochenta del pasado siglo XX. Este proceso tuvo lugar en un marco de participación ciudadana, modernización económica, estado del bienestar, constitución de las comunidades autónomas, sociedad del espectáculo y del entretenimiento, y

Francisco José García Gallardo



Un mito del hambre en el nordeste de Brasil  

Microsoft Academic Search

El objetivo del presente estudio es permitir la comprensión, mediante un abordaje etnográfico, de los significados del hambre en las vivencias de actores sociales que enfrentan la pobreza extrema en un barrio de Salvador, Bahía, Brasil. Los relatos se han analizado con el objeto de entender la construcción de signos inherentes al sufrimiento de quienes padecen de hambre cotidianamente. En

Maria do Carmo S. Freitas; Paulo G. L. Pena




Microsoft Academic Search

El siguiente trabajo (a diferencia de otros) intenta ser un abordaje innovador sobre el tema que denota la etno-psicología del gasto (erogación). Asimismo, su presentación (en forma de comentarios etnográficos o cuaderno de notas) es combinada con datos estadísticos de gran relevancia y comentarios personales del observador durante el trabajo de campo. En este caso, se ha combinado prácticas propias

Maximiliano Korstanje



Del Pezzo surfaces and affine 7-brane backgrounds  

Microsoft Academic Search

A map between string junctions in the affine 7-brane backgrounds and vector bundles on Del Pezzo surfaces is constructed using mirror symmetry. It is shown that the lattice of string junctions with support on an affine 7-brane configuration is isomorphic to the K-theory group of the corresponding Del Pezzo surface. This isomorphism allows us to construct a map between the

Tamás Hauer; Amer Iqbal



The hydrothermal system of Nevado del Ruiz volcano, Colombia  

Microsoft Academic Search

Hot springs and steam vents on the slopes of Nevado del Ruiz volcano provide evidence regarding the nature of hydrothermal activity within the summit and flanks of the volcano. At elevations below 3000 m, alkali-chloride water is discharged from two groups of boiling springs and several isolated warm springs on the western slope of Nevado del Ruiz. Chemical and isotopic

Neil C. Sturchio; Stanley N. Williams; Nestor P. Garcia; Adela C. Londono



confirmation of no X-rays from Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an underestimation of the X-ray background for the particular Swift observation of Nova Del 2013 reported by us in ATel #5314, we agree with the non-detection given on ATel #5318 and determine a 3-sigma upper limit to the Nova Del 2013 count rate of 0.013 counts/sec. We apologize for the confusion.

Castro-Tirado, A. J.; Martin-Carrllo, A.; Hanlon, L.




Microsoft Academic Search

aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado para determinar si los indicadores del estrés oxidativo pudieran ser marcadores tempranos para determinar si los indicadores del

Belkis Martínez Sánchez; Rubén Castillo Jiménez


33 CFR 110.111 - Marina del Rey Harbor, Calif.  

Code of Federal Regulations, 2010 CFR

...Waters 1 2010-07-01 2010-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation...REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel within the...



33 CFR 110.111 - Marina del Rey Harbor, Calif.  

Code of Federal Regulations, 2010 CFR

...Waters 1 2009-07-01 2009-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation...REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel within the...



Orígen del deterioro del medio ambiente en Taiwan: Desajuste entre el modelo de desarrollo y la dotación de recursos naturales  

Microsoft Academic Search

De igual modo que el análisis de los llamados nuevos países industriales asiáticos (NPIAs) abre interesantes matices en el campo de las teorías del desarrollo, poniendo en duda la capacidad explicativa de los enfoques tanto dependentista como neoclásico, el estudio del medio ambiente en esos países aporta visiones nuevas y enriquecidas en lo referente a sus modelos de desarrollo. En

Antonio Rodríguez Carmona



Valoración Económica y Ambiental Aplicada a Casos del Manejo de la Calidad del Aire y Control de la Contaminación  

Microsoft Academic Search

Este documento fue comisionado por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Durante las últimas décadas se han establecido derechos y obligaciones ciudadanas; se han definido las funciones del Estado y de los organismos públicos responsables en materia ambiental; se han realizado

Luis A. Cifuentes; Luis Rizzi; Héctor Jorquera; Javier Vergara



Testing a vapour-phase model of stomatal responses to humidity.  


This study tests two predictions from a recently proposed model for stomatal responses to humidity and temperature. The model is based on water potential equilibrium between the guard cells and the air at the bottom of the stomatal pore and contains three independent variables: gs(0), Z and ?. gs(0) is the value of stomatal conductance that would occur at saturating humidity and will vary among leaves and with CO2 and light. The value of Z is determined primarily by the resistance to heat transfer from the epidermis to the evaporating site and the value of ? is determined primarily by the resistance to water vapour diffusion from the evaporating site to the guard cells. This leads to the two predictions that were tested. Firstly, the values of Z and ? should be constant for leaves of a given species grown under given conditions, although gs(0) should vary among leaves and with light and CO2. And secondly, the ratio of Z to ? should be higher in leaves having their stomata in crypts because the distance for heat transfer is greater than that for water vapour diffusion. Data from three species, Nerium oleander, Pastinaca sativum and Xanthium strumarium support these two predictions. PMID:23072325

Mott, Keith A; Peak, David



Plant sources of chinese herbal remedies: laboratory efficacy, suppression of Meloidogyne javanica in soil, and phytotoxicity assays.  


Extracts of Chinese herbal medicines from plants representing 13 families were tested for their ability to suppress plant-parasitic nematodes. Effective concentration (EC?? and EC??) levels for 18 of the extracts were determined in laboratory assays with Meloidogyne javanica juveniles and all stages of Pratylenchus vulnus. Efficacy of 17 extracts was tested against M. javanica in soil. Generally, EC?? and EC?? values determined in the laboratory were useful indicators for application rates in the soil. Extracts tested from plants in the Liliaceae reduced galling of tomato by M. javanica and were not phytotoxic. Similarly, isothiocyanate-yielding plants in the Brassicaceae suppressed root galling without phytotoxicity. Other plant extracts, including those from Azadirachta indica, Nerium oleander, and Hedera helix, suppressed root galling but were phytotoxic at the higher concentrations tested. Many of these plant sources have been tested elsewhere. Inconsistency in results across studies points to the need for identification of active components and for determination of concentration levels of these components when plant residues or extracts are applied to soil. PMID:19265919

Zasada, I A; Ferris, H; Zheng, L



Determinants of human and mouse melanoma cell sensitivities to oleandrin.  


Oleandrin, a cardiac glycoside component of Nerium oleander, has been shown to induce apoptosis in malignant cells. While human tumor cells are very sensitive to growth inhibition by oleandrin, murine tumor cells are extremely resistant. Using human BRO and mouse B16 melanoma cell lines, we explored several possible determinants of cell sensitivity to oleandrin and compared with ouabain. The studies include Na+, K(+)-ATPase activity and its isoforms as well as the cellular uptake of these cardiac glycosides. Oleandrin and ouabain induced apoptosis was detected in BRO cells while no evidence of cell death was observed in B16 cells even at concentrations 1000-fold higher than that used for BRO cells. Cellular uptake of oleandrin and ouabain was 3-4 fold greater in human BRO tumor cells than murine tumor cells. Partially purified Na+, K(+)-ATPase from human BRO cells was inhibited at a concentration that was 1000-fold less than that was required to inhibit mouse B16 enzyme to the same extent. Using Western blot analyses, human BRO cells were found to express both the sensitive alpha3 isoform and the less sensitive alpha1 isoform of Na+, K(+)-ATPase while mouse B16 cells expressed only the alpha1 isoform. These data suggest that differential expressions of Na+, K(+)-ATPase activities and its isoforms in BRO and B16 cells as well as cellular drug uptake may be important determinants of tumor cell sensitivity to cardiac glycosides. PMID:19066128

Lin, Yun; Dubinsky, William P; Ho, Dah H; Felix, Edward; Newman, Robert A



Carrier frequency of GJB2 gene mutations c.35delG, c.235delC and c.167delT among the populations of Eurasia.  


Hearing impairment is one of the most common disorders of sensorineural function and the incidence of profound prelingual deafness is about 1 per 1000 at birth. GJB2 gene mutations make the largest contribution to hereditary hearing impairment. The spectrum and prevalence of some GJB2 mutations are known to be dependent on the ethnic origin of the population. This study presents data on the carrier frequencies of major GJB2 mutations, c.35delG, c.167delT and c.235delC, among 2308 healthy persons from 18 various populations of Eurasia: Russians, Bashkirs, Tatars, Chuvashes, Udmurts, Komi-Permyaks and Mordvins (Volga-Ural region of Russia); Belarusians and Ukrainians (East Europe); Abkhazians, Avars, Cherkessians and Ingushes (Caucasus); Kazakhs, Uighurs and Uzbeks (Central Asia); and Yakuts and Altaians (Siberia). The data on c.35delG and c.235delC mutation prevalence in the studied ethnic groups can be used to investigate the prospective founder effect in the origin and prevalence of these mutations in Eurasia and consequently in populations around the world. PMID:20739944

Dzhemileva, Lilya U; Barashkov, Nikolay A; Posukh, Olga L; Khusainova, Rita I; Akhmetova, Vita L; Kutuev, Ildus A; Gilyazova, Irina R; Tadinova, Vera N; Fedorova, Sardana A; Khidiyatova, Irina M; Lobov, Simeon L; Khusnutdinova, Elza K



Photoperiodic control of extension growth, bud dormancy and flowering of Nerium indicum Mill. and Thevetia peruviana Schum  

Microsoft Academic Search

Plants ofN. indicum andT. peruviana grew taller and produced more leaves underld than undernd condition. WhileT. peruviana plants were taller and had more leaves undernd than undersd, those ofN. indicum did not differ under the two photoperiods. In both caseslds delayed the onset of bud dormancy but hastened the initiation of floral buds. While inT. peruviana floral buds were not

Kushal Singh; Surinder Kumar; K K Nanda



El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto



La teoría del desarrollo desigual de Oscar Braun. Un análisis crítico  

Microsoft Academic Search

En este análisis crítico de la teoría del intercambio desigual de Oscar Braun, intentamos movernos consistentemente a través de un número de etapas analíticas distintas. Estas etapas son: a) una discusión sobre el objeto del conocimiento en Braun, sin las restricciones de su propia problemática (sección 3); b) una confrontación del objeto del conocimiento en Braun con el objeto real

Richard Brown; Philip Wright



88. Paso Del Norte Hotel, 115117 South El Paso St., ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

88. Paso Del Norte Hotel, 115-117 South El Paso St., south facade, west side of street - South El Paso Street Historic District, South El Paso, South Oregon & South Santa Fe Streets, El Paso, El Paso County, TX


Current Work in Laser Cleaning of the Porta del Paradiso  

NASA Astrophysics Data System (ADS)

This paper summarises the conservation of the Porta del Paradiso, currently underway. It briefly illustrates the two cleaning methods employed and the reasons leading to continue the cleaning of the perimeter panels with laser ablation, describing the various working phases.

Agnoletti, S.; Brini, A.; Nicolai, L.


Proposed Bosque Del Apache Wilderness Area, New Mexico.  

National Technical Information Service (NTIS)

The report describes the proposal which recommends that approximately 32,500 acres within the Bosque del Apache National Wildlife Refuge in Socorro County, New Mexico, be designated as wilderness within the National Wilderness Preservation System. Since d...



Del Bueno Recalls Cheese Because Of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all size packages of Queso Fresco Fresh Cheese, Queso Panela Fresh Cheese, Requeson Mexican Style Ricotta Cheese, and Queso Enchilado Dry Cheese because they have the potential to be contaminated with Listeria ...


Extreme Environments in Tierra del Fuego, Argentina  

NASA Astrophysics Data System (ADS)

The upper timberline of the Andes Cordillera on the island of Tierra del Fuego at the tip of South America is an environment subject to extreme conditions. In order to further understand this environment, ecosystem parameters were measured within two transects of the Andes at Glaciar Martial and Cerro Guanaco. The measurements included pH, soil temperature, soil moisture, nitrogen, sodium and potassium concentration, chlorophyll absorbance, and irradiance in the ultraviolet range (200-400 nm). These data comprise a survey that serves as a baseline for an intensive research program. Chlorophyll concentration and soil data were within the range of our observations at several other sites, from Lapataia Bay on the southwestern boundary with Chile, through the eastern end of Lake Fagnano. However, unusual levels of solar irradiance were found in the open sites of both transects while those in the forest exhibited lower UV values, suggesting strong absorption and/or reflection by the forest canopy. High levels of UV radiation damage important biomolecules and may be partially responsible for the presence of life forms such as the krummholz belt in the upper timberline. These UV values may be due to the effects of global ozone depletion and the ozone hole. The low temperatures, strong winds, snow and ice-covered soil and especially the exposure to UV radiation make this area an extreme environment for life.

Schultz, C.; D'Antoni, H.; Burgess, S.; Zamora, J.; Skiles, J.



Antenatal Rh prophylaxis is unnecessary for “Asia type” DEL women  

Microsoft Academic Search

BackgroundGenerally Rh-negative patients need to be transfused with Rh-negative red blood cells. For pregnant women carrying Rh-positive fetus, the antenatal anti-D detection and Rh immunoglobulin prophylaxis are required worldwide. In East Asia, a RhD variant, termed “Asia type” DEL, was found in approximately 30% of apparent Rh-negative individuals. The antigenic and molecular properties of the DEL were previously defined. Few

Chao-Peng Shao; Hua Xu; Qun Xu; Guo-Dong Sun; Jian-Ping Li; Bo-Wei Zhang; Xiao-Hua Liang; Zhong Liu; Ying Zhou; Dan Li; Nai-Bao Zhuang



L’eruzione laterale etnea del novembre 1950 — dicembre 1951  

Microsoft Academic Search

Conclusione  L’eruzione etnea del 1950–51 si manifestata quasi senza segni premonitori, dopo una breve (meno di un anno) stasi del vulcano.\\u000a Essa si stabilita in una zona che stata gi teatro di precedenti eruzioni (1811) ed ha avuto un’attivit prevalentemente\\u000a effusiva di notevole durata. La lava emessa ha la composizione mineralogica identica alle lave emesse in questo secolo; essa\\u000a si differenzia

Gustavo Cumin



Los cambios comportamentales y del uso del espacio asociados a la muerte del macho dominante de una manada de lobos ibéricos (canis lupus signatus) en el Parque Zoológico de Barcelona  

Microsoft Academic Search

La dinámica social es uno de los campos más estudiados de la familia Canidae en condiciones de cautividad. En este estudio se pretende determinar cómo la muerte del macho dominante de una manada de lobos alojados en el Parque Zoológico de Barcelona afecta al patrón de actividad diario y al uso del espacio del resto de coespecíficos. Los individuos objeto

Ana Isabel Soriano Giménez; Susana Serrat Navarro; Conrad Ensenyat; Carles Riba; Carmen Maté García



Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas


Ongoing near-infrared observations of V339 Del (Nova Del 2013)  

NASA Astrophysics Data System (ADS)

We report continuing 1.08 to 2.35 micron near-infrared spectroscopy of Nova Del 2013 in the J,H,K bands with the Mount Abu 1.2 meter telescope (+ PRL Near-Infrared NICMOS3 Imager/Spectrograph). Subsequent to our initial report on August 28.674 UT (ATel #5337), spectra of the nova have been obtained at regular intervals. The latest spectra of September 16.5 and 19.5 UT are dominated by strong emission lines but the earlier reported strengths of many of the lines have changed significantly.

Banerjee, D. P. K.; Ashok, N. M.; Joshi, Vishal; Evans, Nye



A Case of Near-triploidy in Myelodysplastic Syndrome with del(5q) Combined with del(1p) and del(13q)  

PubMed Central

Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, near-triploidy in myeloid malignancies is associated with poor outcomes. Few studies on near-triploidy in myelodysplastic syndrome (MDS) have been reported, and the clinicopathologic significance of this condition is still unclear. Here, we report a novel case of MDS with near-triploidy and multiple structural chromosomal abnormalities: del(5q) combined with del(1p) and del(13q). These abnormalities were detected by cytogenetic analysis with array comparative genomic hybridization (CGH). Our results suggest that array CGH can be a useful tool for detecting chromosomal abnormalities in patients with MDS.

Kim, Bo-Ram; Kim, Ji-Eun; Woo, Kwang-Sook; Kim, Kyeong-Hee; Kim, Jeong-Man; Lee, Suee; Shaffer, Lisa G.



V339 Del (Nova Del 2013) is a weak non-super-soft X-ray source  

NASA Astrophysics Data System (ADS)

V339 Del (Nova Del 2013) is currently being monitored approximately daily by Swift-XRT. X-ray analysis has been complicated due to optical loading caused by photons from the very bright optical source. (For a discussion of optical loading in the XRT, see our help page.) At early times, the data were collected mainly in Windowed Timing mode to mitigate this issue, and no X-ray source was detected (ATel #5283, #5305, #5318).

Page, K. L.; Beardmore, A. P.



La reparación del daño como mecanismo de tutela de la persona. Del daño a la salud a los nuevos daños extrapatrimoniales  

Microsoft Academic Search

En la actualidad, el operador del Derecho se enfrenta a dos de los más importantes problemas del nuevo derecho de daños: por un lado, la clasificación del perjuicio y, por el otro, la reparación correspondiente a cada una de sus categorías, que debe estar informada por el principio de reparación integral, y que impone en consecuencia considerar más que las

Milagros Koteich Khatib


El valor de uso recreativo de los espacios naturales protegidos. Una aplicación de los métodos de valoración contingente y del coste del viaje  

Microsoft Academic Search

En este articulo se presenta una aplicación de dos de las metodologías desarrolladas para medir los beneficios que se derivan del uso recreativo de los bienes ambientales en ausencia de mercado, el método del coste del viaje (MCV) y el de valoración contingente (MVC). La zona objeto de estudio ha sido el Parque Nacional de “Aigüestortes y Estany de Sant




Componentes naturales y de uso del suelo vulnerables a las variaciones del nivel del mar en la costa atlántica de México  

Microsoft Academic Search

Palabras clave Regionalizaci6n de costas, fislografia, vulnerabilidad costera, uso del suelo Absúact Geomorphological alaradenstia of the mastal iongitudinal prn* and the arrangwent of the physiographical stmcture allowed the rmnition of two zonas: a) the intertidai zone -a basic sntne for dired imoaci of sea leve1 dame: and b) an adjacent peritidál (supralittoral) hnge &n area of cushioning or of polential

Mano Arturo; Ortiz Pérez; Ana Patricia; Méndez Linares


Estudio multifrecuencia del medio interestelar cercano a HD 192281  

NASA Astrophysics Data System (ADS)

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de ?˜21-cm del hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100?m, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5,Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

Arnal, E. M.; Cappa, C. E.; Cichowolski, S.; Pineault, S.; St-Louis, N.


Estudio multifrecuencia del medio interestelar cercano a HD 192281  

NASA Astrophysics Data System (ADS)

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de 21-cm del Hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100 micrones, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5 Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

Arnal, E. M.; Cappa, C.; Cichowolski, S.; Pineault, S.; St-Louis, N.


Categories of massless D-branes and del Pezzo surfaces  

NASA Astrophysics Data System (ADS)

In analogy with the physical concept of a massless D-brane, we define a notion of "" for objects in the derived category. This is defined in terms of monodromy around singularities in the stringy Kähler moduli space and is relatively easy to study using "spherical functors". We consider several examples in which del Pezzo surfaces and other rational surfaces in Calabi-Yau threefolds are contracted. For precisely the del Pezzo surfaces that can be written as hypersurfaces in weighted , the category of objects is a "fractional Calabi-Yau" category of graded matrix factorizations.

Addington, Nicolas; Aspinwall, Paul S.



Fotometría CCD en el campo del cúmulo abierto Ruprecht 58  

NASA Astrophysics Data System (ADS)

La región de Vela-Puppis contiene varios cúmulos cuyo estudio puede brindarnos información acerca de la cinemática y el estado evolutivo de la población estelar en las zonas externas del disco galáctico. A través de observaciones CCD en los filtros UBV en el campo del cúmulo abierto Ruprecht 58 (?2000= 8h 14m 41s, ?2000=-31o 57'), se han determinado por primera vez los parámetros fundamentales de este cúmulo tales como distancia, enrojecimiento y edad. Se analiza también la estructura de su secuencia principal y la presencia de gigantes y binarias.

Giorgi, E. E.; Vázquez, R. A.; Seggewiss, W.; Ostrov, P.; Solivella, G. R.


Continuing optical spectroscopy of V339 Del = Nova Del 2013 with the Nordic Optical Telescope and the ARAS Group  

NASA Astrophysics Data System (ADS)

Since our first report (ATel#5312) we have been continuing nightly, almost hourly spectroscopic observations of V339 Del = Nova Del 2013 = PNV J20233073+2046041). Here we report the state at approximately the t_3 point in the photometric decline (see also ATel#5370). Spectra have been obtained with the 2.6 m Nordic Optical Telecope FIbre-fed Echelle Spectrograph (FIES) (R ~ 67000), the Ondrejov Observatory 2m Zeiss coude spectrograph (R = 18000), and a variety of grating and echelle spectrographs of the ARAS group with resolutions ranging from 580 - 11000.

Shore, S. N.; Alton, K.; Antao, D.; Barbotin, E.; Berardi, P.; Bohlsen, P.; Boubault, F.; Boyd, D.; Briol, J.; Buil, C.; Charbonnel, S.; Dubreuil, P.; Dubs, M.; Edlin, J.; de France, T.; Favaro, A.; Garde, O.; Graham, K.; Greenan, D.; Guarro, J.; Hansen, T.; Hyde, D.; Lemoult, T.; Leadbeater, R.; Martineau, G.; Buchet, Y.; Masviel, J. P.; Montier, J.; Pollmann, E.; Ribeiro, J.; Thizy, O.; Terry, J.-N.; Teyssier, F.



First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

V339 Del = Nova Del 2013 was observed with the Space Telescope Imagine Spectrograph (STIS) aboard the Hubble Space Telescope (HST) on 2013 Sept. 18.2 UT from 1140-2888 A using the E140M and G230H gratings at a resolution of ~ 100000. At the time, V ~ 8, shortly after t_3. Continuing spectroscopy was provided by the Astronomical Ring for Access to Spectroscopy (ARAS) at resolutions ranging from 3684 - 7431 A with resolutions ranging from 580 - 11000 with time sequences as short as 10 minutes at resolutions up to 12000.

Shore, S. N.; Schwarz, G. J.; Alton, K.; Antao, D.; Barbotin, E.; Berardi, P.; Blank, T.; Bohlsen, T.; Boubault, F.; Boyd, D.; Briol, J.; Buil, C.; Charbonnel, S.; Dubreuil, P.; Dubs, M.; Edlin, J.; de France, T.; Favaro, A.; Garde, O.; Graham, K.; Greenan, D.; Guarro, J.; Hansen, T.; Hyde, D.; Lemoult, T.; Leadbeater, R.; Martineau, G.; Buchet, Y.; Masviel, J. P.; Montier, J.; Mauclaire, B.; Pollmann, E.; Ribeiro, J.; Schram, B.; Thizy, O.; Terry, J.-N.; Teyssier, F.; Page, K. L.; Osborne, J. P.; Ness, J.-U.; Starrfield, S.; Walter, F. M.; Woodward, C. E.; Bode, M. F.



The novel c.247_249delTTC (p.F83del) GJB2 mutation in a family with prelingual sensorineural deafness.  


Non-syndromic hearing loss is one of the most common hereditary determined diseases in human, and the disease is a genetically heterogeneous disorder. Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of non-syndromic recessive hearing impairment in many countries and are largely dependent on ethnic groups. Due to the high frequency of the c.35delG GJB2 mutation in the Greek population, we have previously suggested that Greek patients with sensorineural, non-syndromic deafness should be tested for the c.35delG mutation and the coding region of the GJB2 gene should be sequenced in c.35delG heterozygotes. Here we present on the clinical and molecular genetic evaluation of a family suffering from prelingual, sensorineural, non-syndromic deafness. A novel c.247_249delTTC (p.F83del) GJB2 mutation was detected in compound heterozygosity with the c.35delG GJB2 mutation in the proband and was later confirmed in the father, while the mother was homozygous for the c.35delG GJB2 mutation. We conclude that compound heterozygosity of the novel c.247_249delTTC (p.F83del) and the c.35delG mutations in the GJB2 gene was the cause of deafness in the proband and his father. PMID:22484064

Petersen, Michael B; Grigoriadou, Maria; Koutroumpe, Maria; Kokotas, Haris



Screening of 185DelAG, 1014DelGT and 3889DelAG BRCA1 mutations in breast cancer patients from North-East India.  


Around 1.35 million people of worldwide suffer from breast cancer each year, whereas in India, 1 in every 17 women develops the disease. Mutations of the Breast Cancer 1 (BRCA1) gene account for the majority of breast/ ovarian cancer families. The purpose of study was to provide a prevalence of BRCA1 germline mutations in the North-East Indian population. In relation to the personal and family history with the breast cancer, we found mutations in 6.25% and 12.5% respectively. Three mutations, 185DelAG, 1014DelGT and 3889DelAG, were observed in our North-East Indian patients in exons 2 and 11, resulting in truncation of the BRCA1 protein by forming stop codons individually at amino acid positions 39, 303 and 1265. Our results point to a necessity for an extensive mutation screening study of high risk breast cancer cases in our North-East Indian population, which will provide better decisive medical and surgical preventive options. PMID:23317271

Hansa, Jagadish; Kannan, Ravi; Ghosh, Sankar Kumar



Contribució al coneixement dels Noctuidae de la Garrotxa (Catalunya) (Lepidoptera: Noctuidae)  

Microsoft Academic Search

L'objecte d'aquest treball és presentar una actualització del catàleg dels Noctuidae de la Garrotxa. Es donen els resultats de l'estudi del material arreplegat per l'autor durant els darrers deu anys i del dipositat en abres col.leccions, i s'inclouen, també totes les dades de la bibliografia existent. El cens de Noctuidae de la Garrotxa queda establert provisionalment en 309 especies. Es

Josep Bellavista i Admetlla



Delia H. Etcheverry participó en 2008 del Seminario \\  

Microsoft Academic Search

El encaje es una técnica textil relativamente nueva; aparece en Europa en el siglo XVI y tiene su apogeo en los siglos XVII y XVIII. Sin embargo, cuando se menciona que un trabajo de encaje está hecho a mano, inmediatamente se lo asocia a una época mucho más anti­ gua, a piezas del pasado que se han quedado en el

Por Delia Etcheverry


Racionalidad limitada en la sociedad del riesgo mundial  

Microsoft Academic Search

Durante muchas décadas se ha pretendido que la teoría económica de la elección racional es la teoría general del comportamiento humano de la que carecen las ciencias sociales. Este artículo señala algunas de sus limitaciones. La psicología cognitiva describe los sesgos cognitivos de las personas cuando evalúan la información y eligen entre opciones, los cuales ponen en cuestión la idea

Francisco Augusto Laca Arocena



Il ruolo del turismo per l'integrazione Europea  

Microsoft Academic Search

Nell'Unione Europea l'espansione del settore turi stico è destinato a svolgere un ruolo di grande rilievo, per molteplici motivi. Inn anzitutto il turismo ha un notevole impatto economico, in quanto contribuisce positivamente all a creazione di nuovi posti di lavoro e alla crescita di reddito. Inoltre può potenziare le politiche regionali e la politica agricola comune sostenendo lo sviluppo delle

Giulio Querini; Carmen Bizzarri



Las Máscaras Del Héroe: Radiografía De Un Anti-Héroe  

Microsoft Academic Search

Las máscaras del héroe depicts Spanish society from the Second Republic to the start of the Civil War, a period when Spain was torn by poverty and immorality. This intertextual historical novel portrays figures such as Pedro Luis de Gálvez, the last of the bohemians and a failed writer. We encounter Gálvez through the first-person narration of Navales, who hates

Emilio Ramón



The mercury clock of the Libros del Saber  

Microsoft Academic Search

The Libros del Saber de Astronomia is a compilation of various Arabic astronomical works translated into Castilian in the second half of the thirteenth century, under the direction of King Alfonso X of Spain. A section describing a mercury clock has been suggested to be of particular significance in view of the likely invention of the mechanical clock around this

A. A. Mills



Medicine alternative: il senso del male nella postmodernità  

Microsoft Academic Search

Tra modernità e tradizione. E' palese la fortuna che le medicine cosiddette alternative o complementari stanno riscuotendo negli ultimi anni in Italia, come in molti altri Paesi occidentali. Esse interessano un pubblico sempre più ampio e differenziato, ed occupano ormai una fetta consistente dei servizi sanitari e del relativo mercato. Parallelamente, si diffondono in modo assai ampio certe concezioni culturali

Fabio Dei


87. Paso Del Norte Hotel, 115117 South El Paso St., ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

87. Paso Del Norte Hotel, 115-117 South El Paso St., south and east facades, west side of street - South El Paso Street Historic District, South El Paso, South Oregon & South Santa Fe Streets, El Paso, El Paso County, TX



Microsoft Academic Search

Las dificultades que plantea para su clasificación genérica, su filiación lingüística y su interpretación estética hacen de la Razón de amor con los Denuestos del agua y el vino un apasionante enigma de la poesía medieval castellana; y el problema central en torno al cual parecen gravitar todas esas dificultades es la aparente dicotomía y falta de unidad de la

Arsenio Pacheco



Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps  

Microsoft Academic Search

The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing

W. Haeberli; M. Chiarle; G. Mortara; A. Mazza



Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

Ford-Guerrera, Rebecca


Medical Ethnobotany of the Teribes of Bocas del Toro, Panama  

Microsoft Academic Search

Ethnomedical uses of 108 medicinal plant species, belonging to 52 families, 89 genera, used by the Teribe Amerindians of Bocas del Toro Province in Panama, along with their socio-cultural practices are reported here. The methods of administration of the herbal remedies, the plant parts used, their families and local names are also documented. The recorded medicinal plants were used mainly

M. P. Gupta; P. N. Solís; A. I. Calderón; F. Guinneau-Sinclair; M. Correa; C. Galdames; C. Guerra; A. Espinosa; G. I. Alvenda; G. Robles; R. Ocampo



Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

|This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation,…

Ford-Guerrera, Rebecca


Design, aerodynamics and autonomy of the DelFly.  


One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W



Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer




Microsoft Academic Search

Resumen La distensión abdominal es un síntoma común, siendo en general la presentación inicial de enfer- medades sistémicas o desórdenes gastrointestinales. Otras causas son infrecuentes. Los quistes del cordón espermático son poco frecuentes, pero aún más su ubicación intraabdominal, su tamaño habitual es insuficiente para producir distensión. El paciente presentado en este caso es un varón con criptorquidia bilateral admitido



Historia del Tiempo Presente e Historia de las Relaciones Internacionales  

Microsoft Academic Search

Es la Historia del Presente una disciplina en tiempo de elaboración teórica. El rasgo específico de nuestro presente histórico bien pudiera la sociedad tecnológica en construcción. Puesto que la sociedad tecnológica nos introduce en un entorno desterritorializado con un protagonismo de la información sin precedentes en la historia, intuimos que nos adentramos en una sociedad internacional singular, propia exclusivamente de

Montserrat Huguet Santos



Lo multicultural como mitología y como coartada del racismo  

Microsoft Academic Search

La noción de cultura en tanto que conjunto de caracteres de un colectivo nacional, tribal o religioso, ha venido a reemplazar por equivalencia la noción de raza, desprestigiada por la experiencia nazi. Pero su funcionamiento objetivo es el mismo. Raza, nación y cultura son constructos nacidos a la sombra del Romanticismo, de la reacción antiiluminista. El multiculturalismo es la ideología

Horacio Vázquez Rial



Un Análisis del Testimonio en The Little School: Tales of Disappearance and Survival de Alicia Partnoy  

Microsoft Academic Search

El testimonio, como género en la literatura latinoamericana, es muy único. El punto de vista del autor es distinto ya que se deriva del sufrimiento vivido directamente por el testigo. Lo que hace especial al testimonio es la razón principal por la cual se escribe. El testimonio es un acto político que se basa en la fuerza del espíritu de

Jessica Verbanac




Microsoft Academic Search

En la enseñanza del Derecho cobra vida un grupo de categorías didácticas, aplicadas al desarrollo sistémico del proceso docente-educativo, que constituyen la base donde se sostiene una parte importante de la teoría pedagógica. Entre estas categorías se encuentran las formas organizativas y la evaluación del aprendizaje, las que poseen un carácter universal, a partir de su expresión en los distintos

Carlos Justo Bruzón Viltres



Síndrome del cuidador de adultos mayores discapacitados y sus implicaciones psicosociales  

Microsoft Academic Search

Objetivo: Describir la prevalencia del síndrome del cuidador y las características psicosociales de los cuidadores de adultos mayores discapacitados. Materiales y métodos: Se realizó un estudio piloto de casos y controles en el Valle del Cauca durante el 2003-2004 para evaluar la funcionalidad familiar (APGAR familiar), la ansiedad y depresión (escala de Goldberg), la presencia de enfermedades (cuidadores y no




Fallas estructurales del mercado de maíz. Comentario a Robles y García  

Microsoft Academic Search

El artículo es un esfuerzo valioso por parte de economistas para poner (por fin) a funcionar el instrumental de la teoría económica sobre un tema del que sólo parecen ocuparse antropólogos y agrónomos. La carencia de investigación empírica y de reflexión analítica sobre aspectos centrales de la realidad económica del país habla mal del estado que guarda la disciplina de

Ángel Palerm



Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.  

NASA Astrophysics Data System (ADS)

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 ?m, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Muñoz-Caro, Guillermo Manuel


El tutor del docente en formación, figura necesaria en la formación inicial del profesional de la educación  

Microsoft Academic Search

El desarrollo de la universalización pedagógica ha revitalizado el papel del tutor y actualmente cobra mayor importancia si queremos elevar la calidad en la formación y egreso de los futuros docentes. El tutor debe promover, facilitar, ayudar al docente en formación, creando las condiciones para su crecimiento personal y profesional, sin embargo, se ha detectado que es insuficiente su preparación

Maribel Asín Cala; María Isabel Jiménez Martínez; Imara Lay Bravo




Microsoft Academic Search

América Latina y el Caribe es la única región en desarrollo que puede acabar con el hambre en nuestra generación. Tiene 52,4 millones de personas subnutridas (10% de población) y 9 millones de niños con desnutrición crónica, pero también es la principal productora mundial de alimentos y tiene recursos financieros, naturales, humanos e institucionales para hacer del hambre un recuerdo

Jose Luis Viveros; Niemeyer Almeida Filho



The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss  

PubMed Central

Aging is linked to increased susceptibility to chronic inflammatory diseases several of which, including periodontitis, involve neutrophil-mediated tissue injury. Here, we found that aging-associated periodontitis was accompanied by diminished expression of Del-1 (EDIL3), an endogenous inhibitor of LFA-1 integrin-dependent neutrophil adhesion, and by a reciprocal increase in IL-17 expression. Consistently, IL-17 inhibited gingival endothelial cell expression of Del-1, thereby promoting LFA-1-dependent neutrophil recruitment. Young Del-1-deficient mice developed spontaneous periodontitis featuring excessive neutrophil infiltration and IL-17 expression; disease was prevented in Del-1–LFA-1 and Del-1–IL-17 receptor double-deficient mice. Locally administered Del-1 inhibited IL-17 production, neutrophil accumulation, and bone loss. Therefore, Del-1 suppresses LFA-1-dependent neutrophil recruitment and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic for inflammatory diseases.

Eskan, Mehmet A.; Jotwani, Ravi; Abe, Toshiharu; Chmelar, Jindrich; Lim, Jong-Hyung; Liang, Shuang; Ciero, Paul A.; Krauss, Jennifer L.; Li, Fenge; Rauner, Martina; Hofbauer, Lorenz C.; Choi, Eun Young; Chung, Kyoung-Jin; Hashim, Ahmed; Curtis, Michael A.; Chavakis, Triantafyllos; Hajishengallis, George




Microsoft Academic Search

En el presente trabajo se analiza el comportamiento del comercio intraindustrial (CII) de los subsectores representativos de la industria del Valle del Cauca con los países de Ecuador y Venezuela para el período 1980-2006 a través del índice Greenaway y Milner y el índice de Brülhart. De esta forma se corrige el problema de agregación presentado en mediciones anteriores y

Aura María Muñoz Cardona; Lina Johanna Salinas Luna



A model of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

A workshop was held at the Observatorio Vulcanologico de Colombia in Manizales, Colombia, March 28 to April 1, 1988, to review the accumulated data on the disastrous November 13, 1985, eruption and related activity of Nevado del Ruiz volcano (Figure 1). Approximately 30 scientists from eight countries presented data, developed a preliminary model, and addressed the future problems of Ruiz. The volcano (see Figure 2) erupted just prior to the meeting, covering the meeting site with 1-2 mm of ash.The workshop was convened by Stanley N. Williams (Louisiana State University, Baton Rouge) and Hansjürgen Meyer (Universidad del Valle, Cali, Colombia). A special volume of the Journal of Volcanology and Geothermal Research is planned for the papers and letters presented at the workshop, with some additional contributions. Publication is expected in mid-1989.

Williams, Stanley N.; Meyer, Hansjürgen


Recent Optical Spectroscopy of V339 Del 2013  

NASA Astrophysics Data System (ADS)

C. E. Woodward (U. Minnesota), R. M. Wagner (Ohio State U.), R. A. Hounsell (STScI), S. Starrfield (Arizona State U.) report optical spectroscopy of V339 Del obtained on on 2013 October 20.14 UT using the Steward Observatory 2.3 m Bok telescope on Kitt Peak with the B&C spectrograph covering the spectral range 325.0 to 925.0 nm at a spectral resolution of ~0.63 nm. In addition, we obtained an earlier spectrum of V339 Del on 2013 September 5.14 UT with the 2.4 m Hiltner telescope of the MDM Observatory on Kitt Peak using the OSU CCD spectrograph (CCDS) and covering the spectral range 320.0 to 965.0 nm at a spectral resolution of 0.9 nm.

Woodward, C. E.; Wagner, R. M.; Hounsell, R. A.; Starrfield, S.



Biological and behavioral determinants of fertility in Tierra del Fuego.  


The reproductive history of 182 women in postreproductive life or near menopause from the Chilean part of Tierra del Fuego was traced back by means of familial interviews. These postmenopausal women represent the population since almost the beginning of the settlement, and their reproductive years were spent on the island. Path analysis was applied to analyze fertility determinants of these women and to propose a complex model of interconnections among factors. The reproductive history of these women is characterized by a long fertile span, a short childbearing period, and low fertility. Age at menarche is relatively late, and the age of the women at first birth is mainly determined by their late age at marriage. The use of contraception is related to both spacing and stopping behaviors. The late age of women at marriage, the rhythm of conception, and practices of contraception are proposed as the main determinants of fertility in Tierra del Fuego. PMID:15386216

Pascual, J; García-Moro, C E; Hernández, M



El ``Aula del Cel'': astronomy approaching high school  

NASA Astrophysics Data System (ADS)

The “Aula del Cel” is a project carried out by the Astronomical Obsevatory of the University of Valencia, Spain. It offers high-school teachers a tool for teaching Astronomy to 10 to 17 year-old students. Different programs, experiments, and audiovisual presentations have been prepared by a team formed both by professional astronomers and teachers, and are offered in a format chosen to suit each particular age and curriculum group. Special sessions have been designed for students with special needs (for example blind or autistic children) in close contact with the pedagogical teams responsible for their education. Nearly three thousand students have already visited the “Aula del Cel” over the first six months that it has been offered to the school community.

Ortiz-Gil, A.; Gómez Collado, M.; Gallego Calvente, A. T.



Microsoft Academic Search

RIASSUNTO In questo lavoro è stato impiegato e descritto l'utilizzo del Tramadolo per via epidurale durante l'anestesia in un cane che affronta, in successione, tre interventi nella stessa seduta operatoria; il primo in regione perineale seguito da orchiectomia e successivamente l'exeresi di una grossa neoformazione sul gomito. La somministrazione epidurale lombo-sacrale effettuata con Tramadolo a 2mg\\/kg diluito 1:1 in soluzione



Descripción del coronógrafo a ser instalado en Argentina (MICA)  

NASA Astrophysics Data System (ADS)

El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.


An erupted migmatite from Cerro del Hoyazo, SE Spain  

Microsoft Academic Search

The almandine-bearing biotite-cordierite-labradorite dacite of the Cerro del Hoyazo is part of the Neogene volcanic range in SE Spain, extending roughly from Cabo de Gata to Cartagena. About 1 vol. % of the lava consists of rock inclusions, measuring over 1 cm, made up of almandine-biotite-sillimanite gneiss, quartz-cordierite gneiss and spinel-cordierite rock. On the ground of their abundance, chemical composition,

H. P. Zeck



Steroidal saponins from the aerial parts of Tribulus alatus Del  

Microsoft Academic Search

Six steroidal glycosides (1–6) were isolated from the aerial parts of Tribulus alatus Del. (Zygophyllaceae), together with one known cholestane, one spirostane, and six flavonol glycosides. Among them, 1 and 2 possess a furostane-type aglycone, 3 and 6 a cholestane structure, and 4 and 5 a spirostane skeleton. Their structural elucidation was accomplished by extensive spectroscopic methods including 1D (1H,

Abeer Temraz; Omayma D. El Gindi; Hazem A. Kadry; Nunziatina De Tommasi; Alessandra Braca



Prenatal Care in the Paso del Norte Border Region  

Microsoft Academic Search

OBJECTIVES: The impact of a Medicaid-managed care system on access to prenatal care was investigated.STUDY DESIGN: Postpartum interviews and medical chart abstractions were conducted among 493 Hispanic women who reside on the El Paso Texas\\/Juarez Mexico border (the Paso del Norte region). Descriptive analysis identified barriers and facilitators to prenatal care. Logistic regression identified the impact of social and demographic

Judith T Fullerton; Carlene Nelson; Rachel Shannon; Julia Bader



L'Aula del Cel: Communicating Astronomy at School Level  

NASA Astrophysics Data System (ADS)

L'Aula del Cel (The "Sky Classroom") is an effort to bring astronomy closer to school children. It is a project led by the Astronomical Observatory of the University of Valencia in collaboration with the regional education authorities. It has been running for two years and it has been a big success, with nearly three thousand students visiting the Aula during the school term.

Ortiz-Gil, A.; Gomez-Collado, M.; Gallego-Calvente, A. T.



Correction: First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an error in transcription, the distance is given incorrectly in the text of ATel#5409. Along with the typo "Space Telescope Imaging Spectrograph", the text should read: Comparing these STIS UV spectra with high resolution IUE spectra of the CO nova OS And 1986 obtained between 12 days (LWP) and 22 days (SWP) after optical discovery (1986 Dec. 17, 27 respectively) shows a very close agreement such that when independently dereddened, the ratio of V339 Del to OS And between 1200 and 1900A is ~1.5 in flux (similar in the 2000-3000A range but more uncertain because of the earlier date of the long wavelength IUE observation), indicating that the distance to V339 Del is about 4.2 kpc (distance to OS And ~ 5.1 kpc with E(B-V)=0.25+/-0.05, see Schwarz et al.

Shore, S. N.




Microsoft Academic Search

We report 61 new records of alien plants for Torres del Paine National Park. The park is located in the Magellan Region (49°21'-51°08'S y 73°07'-74°52'O), with an area of 181.414 ha. The study area has 21 families, 65 genera and 85 alien species. The families with the largest number of species are Poaceae (22 spp.), Asteraceae (11 spp.) and Caryophyllaceae

Erwin Domínguez; Arve Elvebakk; Clodomiro Marticorena; Aníbal Pauchard


El Vallès Oriental : problemes induïts per l'artificialització del sòl i la preservació del medi ambient  

Microsoft Academic Search

El paisatge i els recursos naturals al Vallès Oriental estan sotmesos a una forta pressió deguda a la progressiva artificialització del medi. L'article proposa una metodologia per tal d'avaluar l'impacte d'aquesta pressió i les mesures correctores que s'hi apliquen. Així, comença per establir una tipologia d'àrees que permet distingir entre municipis desenvolupats, dinàmics, primaris i desafavorits. A continuació proposa un

Jordi Bertran



Su inversioni del campo elettrico terrestre a cielo sereno e una loro possibile spiegazione  

Microsoft Academic Search

\\u000a Sunto  Viene descritto un andamento anomalo del gradiente di Potenziale al Col d’Olen sul Monte Rosa durante una giornata che, dalle\\u000a condizioni atmosferiche, si poteva giudicare del tutto normale.\\u000a \\u000a Del fenomeno si dà una spiegazione plausibile dimostrando corne sia possibile la formazione di cariche spaziali solo che a\\u000a una certa distanza dalla stazione si trovino nubi o semplici strati di nebbia

G. Aliverti; M. C. Montù



VEGF: A modifier of the del22q11 (DiGeorge) syndrome?  

Microsoft Academic Search

Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Here, we report that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11

Ingeborg Stalmans; Diether Lambrechts; Frederik De smet; Sandra Jansen; Jian Wang; Sunit Maity; Paige Kneer; Maren von der Ohe; Ann Swillen; Christa Maes; Marc Gewillig; Daniel G. M. Molin; Peter Hellings; Thurid Boetel; Maartin Haardt; Veerle Compernolle; Mieke Dewerchin; Stephane Plaisance; Robert Vlietinck; Beverly Emanuel; Adriana C. Gittenberger-de Groot; Peter Scambler; Bernice Morrow; Deborah A. Driscol; Lieve Moons; Camila V. Esguerra; Geert Carmeliet; Annett Behn-Krappa; Koen Devriendt; Désiré Collen; Simon J. Conway; Peter Carmeliet



The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins.  


BRCA2-c.2808_2811del (3036delACAA) is one of the most reported germ line mutations in non-Ashkenazi breast cancer patients. We investigated its genetic origin in 51 Spanish carrier families that were genotyped with 11 13q polymorphic markers. Three independent associated haplotypes were clearly distinguished accounting for 23 [west Castilla y León (WCL)], 20 [east Castilla y León (ECL)] and 6 (South of Spain) families. Mutation age was estimated with the Disequilibrium Mapping using Likelihood Estimation software in a range of 45-68 and 45-71 generations for WCL and ECL haplotypes, respectively. The most prevalent variants, c.2808_2811del and c.2803G > A, were located in a double-hairpin loop structure (c.2794-c.2825) predicted by Quikfold that was proposed as a mutational hotspot. To check this hypothesis, random mutagenesis was performed over a 923 bp fragment of BRCA2, and 86 DNA variants were characterized. Interestingly, three mutations reported in the mutation databases (c.2680G > A, c.2944del and c.2957dup) were replicated and 20 affected the same position with different nucleotide changes. Moreover, five variants were placed in the same hairpin loop of c.2808_2811del, and one affected the same position (c.2808A > G). In conclusion, our results support that at least three different mutational events occurred to generate c.2808_2811del. Other highly prevalent DNA variants, such as BRCA1-c.68_69delAG, BRCA2-c.5946delT and c.8537delAG, are concentrated in hairpin loops, suggesting that these structures may represent mutational hotspots. PMID:23929434

Infante, Mar; Durán, Mercedes; Acedo, Alberto; Sánchez-Tapia, Eva María; Díez-Gómez, Beatriz; Barroso, Alicia; García-González, María; Feliubadaló, Lídia; Lasa, Adriana; de la Hoya, Miguel; Esteban-Cardeñosa, Eva; Díez, Orland; Martínez-Bouzas, Cristina; Godino, Javier; Teulé, Alexandre; Osorio, Ana; Lastra, Enrique; González-Sarmiento, Rogelio; Miner, Cristina; Velasco, Eladio A



CHEK2 1100delC and Del5395bp mutations in BRCA-negative individuals from Serbian hereditary breast and ovarian cancer families.  


Purpose: Hereditary breast/ovarian cancer (HBOC) occurs in families with several members affected. Most HBOC is caused by mutations in high penetrance BRCA genes accounting for about 5% of all breast cancers. There is a large number of genes with moderate or low penetrance, contributing to non-BRCA aggregation of breast and ovarian cancers. In the present study, we evaluated the presence and frequency of 1100delC and Del5395 mutations in CHEK2 gene in Serbian BRCA-negative HBOC cases. Methods: We analyzed 57 BRCA-negative subjects from high risk breast/ovarian cancer families from Serbia for CHEK2 1100delC and Del5395 mutations. We used two multiplex allele specific PCR in order to detect them. All suspected positive cases were compared with controls and confirmed by DNA sequencing. Results: 1100delC was not detected in the tested group. However, we detected one Del5395 mutation in a female diagnosed with breast cancer at the age of 32 and with apparent family history of breast cancer (her mother and sister were diagnosed with breast cancer at 42 and 39 years of age, respectively). The frequency of Del5395 mutation in our tested group was 1.7% (1/57). Conclusions: 1100delC variant in CHEK2 gene was not present in the tested subjects from HBOC families in Serbia. However, the finding of Del5395 mutation does not allow us to discard a possible involvement of this gene in breast cancer susceptibility in Serbian population. It would be of great interest to assess the distribution of this large deletion in other countries from the Balkan region in order to assess its geographical distribution and possible founder effect. PMID:24065469

Krivokuca, A; Dobricic, J; Brankovic-Magic, M


Distribución del continuo ultravioleta e infrarrojo en estrellas Be  

NASA Astrophysics Data System (ADS)

Estamos interesados en interpretar los excesos de flujo infrarrojo y/o ultravioleta observados en estrellas Be con respecto al de estrellas B normales, así como su posible correlación. Una envoltura rodeando la estrella distingue una estrella Be de una B normal; para explicar las observaciones es necesario entonces tener en cuenta todos los posibles procesos físicos que en ella tienen lugar. Adoptando un modelo atmosférico específico, hemos estudiado el proceso de recombinación dielectrónica de metales como MgII y FeII, teniendo en cuenta la posible influencia de la opacidad del medio en el flujo emitido.

Cruzado, A.; Ringuelet, A.; di Rocco, H.


An erupted migmatite from Cerro del Hoyazo, SE Spain  

Microsoft Academic Search

The almandine-bearing biotite-cordierite-labradorite dacite of the Cerro del Hoyazo is part of the Neogene volcanic range\\u000a in SE Spain, extending roughly from Cabo de Gata to Cartagena.\\u000a \\u000a About 1 vol. % of the lava consists of rock inclusions, measuring over 1 cm, made up of almandine-biotite-sillimanite gneiss,\\u000a quartz-cordierite gneiss and spinel-cordierite rock. On the ground of their abundance, chemical composition,

H. P. Zeck



X-ray detection of Nova Del 2013 with Swift  

NASA Astrophysics Data System (ADS)

Continuous X-ray monitoring by Swift of Nova Del 2013 (see CBET #3628) shows an increase of X-ray emission at the source location compared to previous observations (ATEL #5283, ATEL #5305) during a 3.9 ksec observation at UT 2013-08-22 12:05. With the XRT instrument operating in window timing mode, 744 counts were extracted from a 50 pixel long source region and 324 counts from a similar box for a background region, resulting in a 13-sigma detection with a net count rate of 0.11±0.008 counts/sec.

Castro-Tirado, Alberto J.; Martin-Carrillo, Antonio; Hanlon, Lorraine



Optical photometry and spectroscopy of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.



Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan.  


Two main research questions are framing this investigation: (1) the main taxa of the medicinal importance value altered the Showbak forest stand and species composition? (2) The most safe species and what are the toxic ones (unsafe). These two research questions are the vital ones to draw a clear image about the wild medicinal plants of this investigated area of Showbak region in Jordan. 79 wild medicinal plant species were investigated in this study which are used in traditional medication for the treatment of various diseases. Most of the locals interviewed dealt with well-known safe medicinal plants such as Aaronsohnia factorovskyi Warb. et Eig., Achillea santolina L., Adiantum capillus-veneris L., Artemisia herba-alba L., Ceratonia siliqua L., Clematis recta L., Herniaria hirsuta L., Malva neglecta Wallr., Rosmarinus officinalis L., Ruta chalepensis L., Salvia triloba L., Sarcopoterium spinosa (L.) Spach., Thymbra capitata (L.) Hof, and Urginea maritima Barker. Many of the wild medicinal plants investigated were toxic and needed to be practiced by practitioners and herbalists rather than the local healers. These plants include Calotropis procera Willd R.Br., Citrullus colocynthis (L.) Sch., Datura stramonium L., Digitalis purpurea L., Ecballium elaterium (L.) A.Rich., Euphorbia helioscopia L., Euphorbia tinctoria Boiss., Glaucium corniculatum (L.) Curt., Hyoscyamus aureus L., Mandragora officinarum L., Nerium oleander L., Ricinus communis L., Solanum nigrum L., Withania somnifera (L.) Dunel. The conservation of medicinal plants and natural resources is becoming increasingly important, so this research is trying to collect information from local population concerning the use of medicinal plants in Showbak; identify the most important specie; determine the relative importance value of the species and calculate the informant consensus factor (ICF) for the medicinal plants. Obtaining results is relied on the interviewee's personal information and the medicinal use of specific plants. PMID:19429338

Al-Qura'n, S



Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.  


Lipid-soluble cardiac glycosides such as bufalin, oleandrin, and digitoxin have been suggested as potent agents that might be useful as anticancer agents. Past research with oleandrin, a principle cardiac glycoside in Nerium oleander L. (Apocynaceae), has been shown to induce cell death through induction of apoptosis. In PANC-1 cells, a human pancreatic cancer cell line, cell death occurs not through apoptosis but rather through autophagy. Oleandrin at low nanomolar concentrations potently inhibited cell proliferation associated with induction of a profound G(2)/M cell cycle arrest. Inhibition of cell cycle was not accompanied by any significant sub G1 accumulation of cells, suggesting a nonapoptotic mechanism. Oleandrin-treated cells exhibited time- and concentration-dependent staining with acridine orange, a lysosomal stain. Subcellular changes within PANC-1 cells included mitochondrial condensation and translocation to a perinuclear position accompanied by vacuoles. Use of a fluorescent oleandrin analog (BODIPY-oleandrin) revealed co-localization of the drug within cell mitochondria. Damaged mitochondria were found within autophagosome structures. Formation of autophagosomes was confirmed through electron microscopy and detection of green fluorescent protein-labeled light chain 3 association with autophagosome membranes. Also observed was a drug-mediated inhibition of pAkt formation and up-regulation of pERK. Transfection of Akt into PANC-1 cells or inhibition of pERK activation by MAPK inhibitor abrogated oleandrin-mediated inhibition of cell growth, suggesting that the reduction of pAkt and increased pERK are important to oleandrin's ability to inhibit tumor cell proliferation. The data provide insight into the mechanisms and role of a potent, lipid-soluble cardiac glycoside (oleandrin) in control of human pancreatic cancer proliferation. PMID:18048883

Newman, Robert A; Kondo, Yasuko; Yokoyama, Tomohisa; Dixon, Susan; Cartwright, Carrie; Chan, Diana; Johansen, Mary; Yang, Peiying



Crueldad, simulacion, absurdo y amenaza: Barbarie del drama moderno y tradicion hermetica en los esperpentos de Ramon del Valle-Inclan  

Microsoft Academic Search

The purpose of this dissertation is to demonstrate that the esperpentos by the Spanish playwright Ramón del Valle-Inclán (1866–1936), represent a culminating moment of theatrical precepts of modern European drama, while perpetuating the ancient esoteric traditions of the Iberian Peninsula. Focusing on four plays—Los cuernos de Don Friolera (1920), Luces de Bohemia (1921), Las galas del difunto (1926) y La

Barbara Safille




Microsoft Academic Search

En el proceso de extracción de cloruro de sodio a partir de agua de mar queda una salmuera residual rica en sales de sodio y magnesio que al ser tratadas químicamente y al ser evaporada permite recuperar aproximadamente el 75% del cloruro de sodio que queda en dicho residual, lo que puede reducir la contaminación ambiental del litoral y generar

Mariana Estela Colombat Rodríguez; Amada Lissett Colombat Rodríguez




Microsoft Academic Search

La gestione delle infestanti è una pratica fondamentale nella coltivazione del mais. Il tempo di comparsa delle malerbe influenza la competizione tra infestante e specie coltivata determinando l'entità del danno che le malerbe possono provocare in termini di resa della coltura. La capacità di prevedere le emergenze delle malerbe può aiutare ad ottimizzare i tempi di controllo, può aumentare l'efficacia

Roberta Masin; Giuliano Cacciatori; Maria Clara Zuin; Giuseppe Zanin


Estrategia para potenciar el desarrollo del talento en los escolares de la educación primaria  

Microsoft Academic Search

El desarrollo del talento en el mundo es una polémica que cobra auge en la actualidad. Cuba, país en vía de desarrollo brinda a este tema especial atención. Por su importancia y novedad, la presente investigación se centra en cómo potenciar el desarrollo del talento en la Educación Primaria. Con un enfoque histórico cultural la estrategia propuesta como vía de

Niurkis Lozano Cabrera




Microsoft Academic Search

El origen de la teoría del apego se remonta a los trabajos etológicos de Lorenz con patos silvestres. Según la observación de este autor, se notaba en los patos cierto apego entre la madre y sus crías minutos después de los nacimientos; dicho lazo duraría gran parte de la vida biológica del animal (Bowlby, 1986; 1989). Con estas observaciones en

Maximiliano Korstanje



Contrastación del modelo de in versión de Rusbult en una muestra de casados y divorciados  

Microsoft Academic Search

Este estudio examina la capacidad del modelo de in versión propuesto por Rusbult para diferenciar en - tre individuos en relaciones estables e individuos en relaciones inestables, así como la capacidad de las variables del modelo (satisfacción matrimonial, in versión y relaciones alternati vas) para predecir el compromiso y la estabilidad de las relaciones matrimoniales. Los datos sobre las varia

David Martínez-Íñigo



El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.


61. M.C., photographer June 22, 1951 KLAMATH, DEL NORTE COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. M.C., photographer June 22, 1951 KLAMATH, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #452 NORTHERLY THROUGH KLAMATH FROM STA. 325+50, 6/22/51, M.C. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA


Indicador espacial del metabolismo urbano. Huella Ecológica de la ciudad de Tandil, Argentina  

Microsoft Academic Search

Además de problemas urbanos evidentes -contaminación, residuos, etc.-, existe un problema asociado a la propia dinámica del sistema urbano que es de interés: la apropiación creciente de ecosistemas productivos externos destinados a satisfacer los requerimientos del metabolismo urbano de la ciudad de Tandil, Argentina. Se emplea para su cálculo, la Huella Ecológica (HE) (Rees 1996a; Wackernagel 1996) que permite evaluar

Elsa Marcela Guerrero; Fernando Guiñirgo



Experience the magic of light and color: outreach activity by Universidad del Valle student chapter  

Microsoft Academic Search

During 2007, the Universidad del Valle Student Chapter presented a proposal for developing an educational outreach activity for children from an underprivileged zone to the Optical Society of America Foundation (OSAF) and to SPIE. The activity was carried out jointly by OSA and SPIE Universidad del Valle Student Chapters in the hillsides of Santiago de Cali, in a zone known

Claudia Valdes; Camilo Reyes; Alberto Osorio; Efrain Solarte



Quattordici Punti di accordo con i rapporti ufficiali governativi sulla distruzione del World Trade Center  

Microsoft Academic Search

I rapporti di FEMA e NIST contengono la versione ufficiale sulla distruzione del World Trade Center, avvenuta l'11 settembre 2001. In questa lettera vogliamo porre le basi per una discussione costruttiva e chiarificatrice, focalizzandoci sui punti di comune accordo con FEMA e NIST, e refutando nel contempo diverse credenze errate sui crolli del WTC. L'undici settembre 2001 le Torri Gemelle

Steven E. Jones; Frank M. Legge; Kevin R. Ryan; Anthony F. Szamboti; James R. Gourley


Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT): preguntas y respuestas

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años, no impide el cáncer de próstata.


Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT)

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años y medio, no impiden el cáncer de próstata.


33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Delaware Bay off Cape Henlopen, Del.; naval...RESTRICTED AREA REGULATIONS § 334.110 Delaware Bay off Cape Henlopen, Del.; naval...Beginning at a point on the south shore of Delaware Bay at longitude 75°06â²12â³; thence to latitude...



33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2010 CFR

...Waters 2 2010-07-01 2010-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200...INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area ....



33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2010 CFR

...Waters 2 2009-07-01 2009-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200...INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area ....



C.35delG/ GJB2 and del(GJB6-D13S1830) mutations in Croatians with prelingual non-syndromic hearing impairment  

PubMed Central

Background C.35delG/GJB2 mutation is the most frequent genetic cause of deafness in Caucasians. Another frequent mutation in some Caucasian populations is del(GJB6-D13S1830). Both GJB2 and GJB6 genes belong to the same DFNB1 locus and when the two mutations are found in combination in a hearing-impaired person, a digenic pattern of inheritance is suggested. Methods We examined 63 Croatian subjects (25 familial and 38 sporadic cases) with prelingual non-syndromic hearing impairment by polymerase chain reaction for the presence of the c.35delG/GJB2 and the del(GJB6-D13S1830) mutations. Results Of the 63 unrelated hearing-impaired subjects, the mutation c.35delG/GJB2 was found in 21 subjects (33.3%). In 5 of them the mutation was found in the heterozygous state, all of them being compound heterozygotes, as sequencing revealed a second mutation within the coding region of the gene in 3 subjects, and a splice site mutation in 2 subjects. The del(GJB6-D13S1830) mutation was not found in the investigated hearing-impaired Croatian subjects. Conclusion Our results contribute to the knowledge of geographic distribution and population genetics of the GJB2 and GJB6 mutations in the Europeans.

Medica, Igor; Rudolf, Gorazd; Balaban, Manuela; Peterlin, Borut



33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal). 162.40 Section 162...REGULATIONS § 162.40 Inland waterway from Delaware River to Chesapeake Bay, Del. and...



33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... § 207.100 Inland waterway from Delaware River to Chesapeake Bay, Del. and...



33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... § 207.100 Inland waterway from Delaware River to Chesapeake Bay, Del. and...



Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect  

PubMed Central

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF.

Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stephanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noelie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander



High precision ages from the Torres del Paine Intrusion, Chile  

NASA Astrophysics Data System (ADS)

The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic complex by the granite and we conclude that some parts of the mafic complex were emplaced before the granite. The well defined 206/238U-age for zircons and the slightly younger 40Ar/39Ar -ages for biotites of both rock suites show that emplacement and cooling of the Torres del Paine Intrusion took place in a relatively short time-frame. Halpern, 1973, Geological Society of America Bulletin, 84/7: 2407-2422. Sanchez, 2006. V SSAGI, Punta del Este, April 2006.

Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.



Numerical Kähler-Einstein Metric on the Third del Pezzo  

NASA Astrophysics Data System (ADS)

The third del Pezzo surface admits a unique Kähler-Einstein metric, which is not known in closed form. The manifold’s toric structure reduces the Einstein equation to a single Monge-Ampère equation in two real dimensions. We numerically solve this nonlinear PDE using three different algorithms, and describe the resulting metric. The first two algorithms involve simulation of Ricci flow, in complex and symplectic coordinates respectively. The third algorithm involves turning the PDE into an optimization problem on a certain space of metrics, which are symplectic analogues of the “algebraic” metrics used in numerical work on Calabi-Yau manifolds. Our algorithms should be applicable to general toric manifolds. Using our metric, we compute various geometric quantities of interest, including Laplacian eigenvalues and a harmonic (1,1)-form. The metric and (1,1)-form can be used to construct a Klebanov-Tseytlin-like supergravity solution.

Doran, Charles; Headrick, Matthew; Herzog, Christopher P.; Kantor, Joshua; Wiseman, Toby



Renewable energy load assessment for Boquillas Del Carmen Coahuila, Mexico  

SciTech Connect

This report outlines the estimates that were made in 1992 of the potential load requirements for Boquillas del Carmen, a small Mexican village on the northern border of the state of Coahuila, Mexico near Big Bend National Park in southern Texas. The study was made to help determine the possibility that village might be electrified by solar or wind energy. Various estimates of are given of the potential load based on estimates ranging from basic use of lights, radio, television, and small household appliances to microwave ovens, refrigerators, and direct evaporative coolers. The low-energy consumption case was estimated to be at 23.0 kWh/month per residence per month, and the high-energy consumption case (with cooling) was 140.7 kWh/month per residence. On average, the typical residence is occupied by five individuals.

Foster, R. [Southwest Technology Development Institute, Las Cruces, NM (United States)



Near-IR Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report Near-IR photometry of Nova Del 2013 taken with the 0.76-m infrared telescope at the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). RIJHKLM photometry were obtained on August 21.17 and 23.13 UT using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 21.17 UT: R = 5.1 +/- 0.1, I = 4.6 +/- 0.1, J = 4.6 +/- 0.1, H = 4.1 +/- 0.1, K = 3.9 +/- 0.1, L = 2.7 +/- 0.2, M = +2.2 +/- 0.2.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.



Impacto de las Tecnologías de la Información y las Comunicaciones (TIC) en el desarrollo y la competitividad del país  

Microsoft Academic Search

La primera parte de este estudio caracteriza al sector de telecomunicaciones en Colombia, comparando a Colombia con otros países y regiones del mundo, mostrando la evolución de algunos de los principales indicadores de telecomunicaciones. En la segunda parte se hacen estimaciones cuantitativas del impacto socioeconómico del sector en la economía colombiana, a través de dos herramientas: la metodología insumo-producto y

Juan Benavides; Felipe Castro; Lina Devis; Mauricio Olivera




Microsoft Academic Search

Este artículo trata sobre el papel preponderante que juegan los Auxiliares de la Justicia que cobra mayor relevancia dentro del engranaje del modelo del Sistema Acusatorio, en los Procesos Orales, garantista en Contra posición con el actual Sistema Inquisitivo destacando el trabajo, capacidad y preponderancia de Estos colaboradores muchas veces anónimos en el Sistema actual, pero que serán de suma

Ivanovha Lamela



Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile  

NASA Astrophysics Data System (ADS)

The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and a detailed account of palaeoclimate in subantarctic Patagonia. Chronology over the 262-cm length of core is regulated by 20 AMS radiocarbon dates between 14 455 and 10 089 14C yr BP. Of 13 pollen assemblage zones, the earliest representing the Oldest Dryas chronozone (14 455-13 000 14C yr BP) records impoverished steppe with decreasing frequencies and loss of southern beech (Nothofagus). Successive 100-yr-long episodes of grass/herbs and of heath (Empetrum/Ericaceae) before 14 000 14C yr BP infer deglacial successional communities under a climate of increased continentality prior to the establishment of grass-dominated steppe. The Bølling-Allerød (13 000-11 000 14C yr BP) is characterised by mesic grassland under moderating climate that with abrupt change to heath dominance after 12 000 14C yr BP was warmer and not as humid. At the time of the Younger Dryas (11 000-10 000 14C yr BP), grass steppe expanded with a return of colder, more humid climate. Later, with gradual warming, communities were invaded by southern beech. The Puerto del Hambre record parallels multistep, deglacial palaeoclimatic sequences reported elsewhere in the Southern Andes and at Taylor Dome in Antarctica. Deglaciation of Estrecho de Magallanes-Bahía Inútil is dated close to 14 455 14C yr BP, invalidating earlier dates of between 15 800 and 16 590 14C yr BP.

Heusser, Calvin J.; Heusser, Linda E.; Lowell, Thomas V.; Moreira M., Andrés; Moreira M., Simón



[Epidemiology of dog bite lesions in Tierra del Fuego, Argentina].  


The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health centers was carried out between 3/1/05 and 3/1/06. A total of 382 records were made. The children group represents 49.5%. The group between 5 and 9 year-old was the most affected (44.4%; IC95% 37.2-51.8). In the adult group, that between 15 and 24 year-old was the most affected (29.5%; IC95% 23.2-36.5). More lesions were registered in men (57.6%) than in women (42.4%) (chi2 = 8.6, p = 0.003). During spring and summer months, 56.5% of the lesions were registered. A 72.8% of the incidents occurred on the public highway. Dogs of big size were responsible of 49.7% (IC95% 44.6-54.9) of the injuries. The 89.8% of the incidents were caused by another person's dog. Of the lesions, 55.8% (IC95% 50.6-60.8) were registered in lower extremities and 11% (IC95% 8.1-14.7) in head and neck. These data show that dog bite lesions affect the health and impact in the quality of life of the population of Tierra del Fuego, Argentina. PMID:18416313

Zanini, Fabián; Padinger, Patricia; Elissondo, María C; Pérez, Héctor



FISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians  

PubMed Central

Background B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of the correlation of these chromosomal abnormalities with laboratory features and clinical course of the disease. The most frequent genomic changes are deletions at 13q14, 11q22-23 and 17p13 and trisomy of chromosome 12. Objectives The aim of this study was to investigate the frequency of chromosomal aberrations in B-CLL patients’ peripheral blood and/or bone marrow using a molecular cytogenetic method, interphase fluorescence in situ hybridization (I-FISH) and to evaluate the correlation between these genomic changes and clinical findings. Patients and Methods I-FISH analyses were performed on bone marrow and blood samples of 66 B-CLL patients. Results Deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). Statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings with family history, Rai staging and CD38 marker. No clear differences in distribution was noted for del17p13 and del6q21 among patients with and without family history, and no direct correlation was noted between these genomic changes and CD38 marker, but the correlation of del17p13 and Rai stage was significant. There was a high frequency of Rai stage II within del17p13 patients. Conclusions It was demonstrated that the presence of del6q21 in B-CLL patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease.

Teimori, Hossein; Ashoori, Saeede; Akbari, Mohamad Taghi; Mojtabavi Naeini, Marjan; Hashemzade Chaleshtori, Morteza



33 CFR 162.35 - Channel of Christina River, Del.; navigation.  

Code of Federal Regulations, 2013 CFR

...Christina River, Del.; navigation. (a) That vessels of over 20 tons capacity, propelled by machinery, shall not proceed at any time within the limits of these waters at a greater speed than 8 statute miles per...



Intestinal Parasites of Man in Agusan del Norte, Philippines with Emphasis on Schistosomiasis and Capillariasis.  

National Technical Information Service (NTIS)

A total of 1,920 fecal specimens from residents of seven villages in Agusan del Norte Province, Mindanao, Philippines were examined for schistosomes and common intestinal parasites. Schistosoma japonicum eggs were found in 14% of the samples. Infections i...

W. P. Carney R. Nocun A. G. Vergel I. Pagaran A. Mercado



Notes on the Geochemical Survey in Zamboanga Del Norte - Misamis Occidental, Mindanao, Philippines.  

National Technical Information Service (NTIS)

Stream sediment and panned heavy mineral surveys were conducted in Zamboanga del Norte and Misamis Occidental provinces in northwestern Mindanao. A total of 70 stream sediments and 64 panned heavy mineral concentrates were obtained along active streams dr...

G. Santos J. E. Seguis L. Carino P. Escalada L. Antonio



Del Bueno Amends Recall of Queso Fresco Cheese Because of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all size packages of Queso Fresco Fresh Cheese because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, ...


Elementos para una reforma del sector público en el contexto de una economía de mercado  

Microsoft Academic Search

En este trabajo se propone un conjunto de elementos básicos que deben ser considerados para el diseño de cualquier estrategia de reforma del sector público en el Perú, abordando cuestiones de carácter económico, social, político y de organización institucional.

Claudio Herzka



Geostatistical investigations of rock masses. The Sierra del Medio Case (Argentina).  

National Technical Information Service (NTIS)

The geostatistical tehniques applied for the selection of a minimun fracturation volume in Sierra del Medio allow to quantify and qualify the variability of mechanic characteristics and density of fracture and also the level of reliability in estimations....

J. A. Matar M. A. Sarquis J. P. Girardi G. H. Tabbia



The Ecology and Distribution of Rock-Boring Pelecypods off Del Monte Beach, Monterey, California.  

National Technical Information Service (NTIS)

Divers using SCUBA gear gathered and identified rock-boring pelecypods found in the subtidal outcrops of Monterey silicious shale off Del Monte Beach, Monterey, California. Underwater photographs were taken of all the recognizable species present. A speci...

G. S. Booth



Estudio multiespectral del remanente de supernova W 28  

NASA Astrophysics Data System (ADS)

Se presentan observaciones en continuo de radio con muy alta resolución angular y sensibilidad del remanente de supernova (RSN) W28. Las observaciones fueron realizadas con el interferómetro Very Large Array (Estados Unidos), en las configuraciones C y D, en 1415 y 324 MHz. Por la gran extensión de este remanente (diámetro ~ 1o), las observaciones en 1415 MHz se realizaron en modo mosaico, combinando 48 apuntamientos diferentes en una única imagen. En ambas frecuencias los datos se procesaron con el agregado de observaciones de menor resolución angular, a fin de recuperar información en todas las frecuencias espaciales y obtener estimaciones precisas de densidad de flujo. Las imágenes resultantes muestran por primera vez la presencia de extensiones con forma de arco, cuya naturaleza se investiga. Las observaciones en radio se comparan con una imagen óptica de W28, y con la emisión en rayos X, observada con el satélite ROSAT. Este remanente muestra una clara morfología híbrida, tipo cáscara en frecuencias de radio y de centro lleno en las bandas óptica y de rayos X blandos.

Dubner, G.; Velázquez, P.; Castelletti, G.


Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.



Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.



``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism  

NASA Astrophysics Data System (ADS)

In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

López, Alejandro Martín; Altman, Agustina



L’evolució del pensament escolar al Principat (1808-1845)  

Microsoft Academic Search

L’article analitza la implantació i el desenvolupament de l’ educació escolar a les primeres dècades del segle XIX a Catalunya, concretament des de l’arribada de les tropes napoleòniques el 1808 fins a la consolidació de la reforma liberal de 1845. S’hi realitza una anàlisi cronològica dels esdeveniments polítics, legals i culturals més importants, i s’aprofundeix en el pensament escolar d’aquesta

Jordi Monés i Pujol-Busquets



NCI ofrece apoyo a quienes están necesitados después del huracane Katrina

El Instituto Nacional del Cáncer (NCI), parte de los Institutos Nacionales de la Salud (NIH), está empeñado en ayudar a las miles de personas que han sido asoladas por los efectos del huracán Katrina. NCI está tratando de llegar a los públicos diversos para proporcionarles información relacionada con el cáncer que pueda ser compartida con exactitud y efectividad con quienes han sido afectados por el huracán.


CHEK2 1100delC mutation is frequent among Russian breast cancer patients  

Microsoft Academic Search

This study was aimed to assess the role of CHEK2 1100delC mutation in breast cancer (BC) predisposition in Russia. The 1100delC allele was detected in 14\\/660 (2.1%) unilateral BC cases and in 8\\/155 (5.2%) patients with the bilateral form of the disease, but only in 1\\/448 (0.2%) middle-aged control females and in none of 373 elderly tumor-free women. The obtained

Elena V. Chekmariova; Anna P. Sokolenko; Konstantin G. Buslov; Aglaya G. Iyevleva; Yulia M. Ulibina; Maxim E. Rozanov; Natalia V. Mitiushkina; Alexandr V. Togo; Dmitry E. Matsko; Dmitry A. Voskresenskiy; Oleg L. Chagunava; Peter Devilee; Cees Cornelisse; Vladimir F. Semiglazov; Evgeny N. Imyanitov



La ceràmica de procedència sud-itàlica del Museu Episcopal de Vic  

Microsoft Academic Search

En aquest article s’estudien tretze vasos ceràmics procedents del sud d’Itàlia que formen part de la col·lecció de ceràmiques gregues, etrusques, falisques i sud-itàliques del Museu Episcopal de Vic (MEV). Es tracta d’un conjunt homogeni pel que fa a l’origen geogràfic, ja que tots els exemplars provenen de l’Apúlia preromana, avui regió de la Pulla. Els vasos abasten un ventall



Aplicación del método SAC a líneas de Fe II en atmósferas extendidas de estrellas Be  

NASA Astrophysics Data System (ADS)

En el presente trabajo hemos analizado las líneas de Fe II en emisión, para varios multipletes en el rango óptico, presentes en los espectros de un grupo de estrellas Be. Mediante la aplicación del método de curvas de autoabsorción (SAC), obtenemos una estimación del valor de los parámetros característicos de la región en la cual se forman dichas líneas, tales como temperatura de excitación, opacidad y dimensión.

Arias, M. L.; Zorec, J.; Cidale, L.; Morrell, N.; Friedjung, M.; Chauville, J.; Ballereau, D.



Microsoft Academic Search

RESUMEN. En este trabajo se presenta una revisión de los cambios que se han producido en los últimos años en las ecuaciones de estado cúbicas de más amplia aceptación y se hace un estudio comparativo del cálculo del volumen específico de once líquidos puros por medio de cinco ecuaciones cúbicas: Van der Waals, Redlich-Kwong, Soave-Redlich-Kwong, Peng-Robinson y Valderrama-Patel- Teja .



Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications  

PubMed Central

Introduction Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. Methods In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. Results We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels. Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. Conclusions We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions, we identified potential drivers of CHEK2 1100delC-associated tumorigenesis, whose role in cancer progression is worth investigating. Furthermore, poorer survival related to the CHEK2 1100delC gene-expression signature highlights pathways that are likely to have a role in the development of metastatic disease in carriers of the CHEK2 1100delC mutation.




Microsoft Academic Search

El presente trabajo investigativo realizado en la comunidad René Almanza Soto, del consejo popular 01 en Amancio, constituyó una gran experiencia ya que el objeto de la recreación física son indudablemente los gustos y preferencias recreativas de la población, a través de este método logramos incorporar gran parte de los habitantes a la realización de las actividades físicas recreativas que

Rosalba Mensoney Liben; Gerardo Sutherland Lemes




Microsoft Academic Search

RESUMEN: En el presente trabajo se aborda el estudio de las flechas en el Arte Levantino a partir de su contrastación con los proyectiles en piedra tallada recuperados en los yacimientos meso- líticos y neolíticos más próximos a los abrigos pintados del núcleo de la Valltorta-Gasulla. El aná- lisis de las diferentes modalidades de representación y las distintas propuestas de



Valoración Económica del Manejo Sustentable de la Calidad del Aire y de la Contaminación: Ejemplos de Experiencias, Implicaciones Políticas y Aplicabilidad en el Contexto de la Región  

Microsoft Academic Search

Esta presentación fue comisionada por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Las ciudades de Latinoamérica tienen niveles altos de contaminación atmosférica, principalmente de material particulado. No hay duda de que la contaminación atmosférica produce efectos nocivos a altas concentraciones, pero la

Luis A. Cifuentes



L'assimilació dels historicismes en l'arquitectura domèstica del segle XIX. De la dependència formal a la consecució d'un estil propi  

Microsoft Academic Search

Aquí se pretende analizar la influencia de los diferentes historicismos en la arquitectura doméstica del siglo XIX a través de las diferentes capitales europeas. Así, se observa cómo la influencia de los estilos históricos, tan importante en la arquitectura oficial y representativa, se limita al uso de algunos elementos estilísticos concretos, pero sin llegar nunca a reproducciones completas de edificios

Joan Molet i Petit



Identification of novel mutations in the ABCA12 gene, c.1857delA and c.5653-5655delTAT, causing harlequin ichthyosis.  


Harlequin ichthyosis (HI) is a severe autosomal recessive developmental disorder of the skin that is frequently but not always fatal in the first few days of life. In HI, mutations in both ABCA12 gene alleles must have a severe impact on protein function and most mutations are truncating. The presence of at least one nontruncating mutation (predicting a residual protein function) usually causes a less severe congenital ichthyosis (lamellar ichthyosis or congenital ichthyosiform erythroderma). Here we report on a girl with severe HI diagnosed by prenatal ultrasound at 33 5/7week gestation. Ultrasound findings included ectropion, eclabium, deformed nose, hands and feet, joint contractures, hyperechogenic amniotic fluid and polyhydramnion. After birth, palliative treatment was provided and she died on her first day of life. Sequence analysis of the ABCA12 gene identified two novel mutations, c.1857delA (predicting p.Lys619*) in exon 15 and c.5653-5655delTAT (predicting p.1885delTyr) in exon 37, each in heterozygous state. The c.5653-5655delTAT mutation is not truncating, but the deleted tyrosine at position 1885 is perfectly conserved among vertebrates and molecular studies evaluated the mutation as probably disease causing and damaging. PMID:24055722

Follmann, Johannes; Macchiella, Doris; Whybra, Catharina; Mildenberger, Eva; Poarangan, Cornelia; Zechner, Ulrich; Bartsch, Oliver



Captura y Reconfiguración Cooptada del Estado en Guatemala, México y Colombia Análisis conceptual de las memorias de la Primera Discusión Internacional Sobre Captura y Reconfiguración Cooptada del Estado  

Microsoft Academic Search

La evidencia muestra que el narcotráfico es importante en el fortalecimiento de la corrupción de Guatemala, México y Colombia; por lo tanto, es problemático analizar de modo separado ambos fenómenos. Los hechos muestran también que las organizaciones narcotraficantes de los tres países han aprendido a regular la coerción del Estado. Este aprendizaje ha representado un salto que va desde la

Luis Jorge Garay-Salamanca; Isaac de León-Beltrán; Eduardo Salcedo-Albarán



La red exterior de Puertos del Estado: Información oceanográfica en tiempo real. Puertos del Estado deep water network: Oceanographic information in real time  

Microsoft Academic Search

SUMMARY In the last 20 years, Puertos del Estado has settled a complex marine monitoring system that allows the access to real time oceanographic and meteorological information. One of the networks in this system is the deep water network with buoys deployed at open sea. The access to this information is completely free through the web pages where users can

Marta Alfonso; José Damián López; Isabel Ruiz; Enrique Álvarez; Nuevas Tecnologías


Bidimensional spectroscopy of HR Del shell with GMOS-IFU  

NASA Astrophysics Data System (ADS)

The slow and bright classical nova HR Del 1967 was observed in the optical using GEMINI-NORTH GMOS-IFU in 2002 with a spectral range from 0.4 ?m to 1 ?m, a resolution of ˜ 300 km/s, and spatial resolution of ˜ 0''.5. Line intensity maps were obtained for H? +[NII], [OIII] 5007, H? and helium lines. The shell showed a bipolar and clumped structure resembling the shell observed in 1998 (Harman and O'Brien 2003). The [OIII] 5007 map showed seven bright knots. Models of the central source, shell and knots spectra were performed using CLOUDY 94 (Ferland et al. 1998) and RA3D (Diaz 2001). Central source spectra were best fitted with a T_{eff} = 60000 K, log(g) = 6 and log(L_*) = 36.6 Rauch atmosphere model. Shell H-density law was modeled using a power law with ? parameter -1.2 and mass = 4.1 × 10^{-4} M_?. The knots spectra were fitted as gaussian condensations with ˜ 50000cm^{-3} peak H-density and ˜ 20000cm^{-3} average H-density. HeII 4686 emission was found in the knots. The HeII origin is atributted to projected emission from diffuse matter in front of the knots, hypothesis corroborated by about the same HeII intensity observed outside the knots. Physical parameters of the condensations were obtained from our analysis and helium abundances were recalculated. A peak density contrast N/N_S = 270 was found when compared to the medium outside the knots. Electron temperatures ˜ 9500 K, electron densities ˜ 20000cm^{-3} and helium number abundance ˜ 0.2 were derived. Our results showed a constant helium abundance within a narrow radius range which is consistent with impulsive ejection (Kato and Hachisu 1994).

Augusto, A.; Diaz, M.



Predicting Nonspecific Ion Binding Using DelPhi  

PubMed Central

Ions are an important component of the cell and affect the corresponding biological macromolecules either via direct binding or as a screening ion cloud. Although some ion binding is highly specific and frequently associated with the function of the macromolecule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic attraction is strong enough to immobilize them. Here, we test such a scenario and demonstrate that experimentally identified surface-bound ions are located at a potential that facilitates binding, which indicates that the major driving force is the electrostatics. Without taking into consideration geometrical factors and structural fluctuations, we show that ions tend to be bound onto the protein surface at positions with strong potential but with polarity opposite to that of the ion. This observation is used to develop a method that uses a DelPhi-calculated potential map in conjunction with an in-house-developed clustering algorithm to predict nonspecific ion-binding sites. Although this approach distinguishes only the polarity of the ions, and not their chemical nature, it can predict nonspecific binding of positively or negatively charged ions with acceptable accuracy. One can use the predictions in the Poisson-Boltzmann approach by placing explicit ions in the predicted positions, which in turn will reduce the magnitude of the local potential and extend the limits of the Poisson-Boltzmann equation. In addition, one can use this approach to place the desired number of ions before conducting molecular-dynamics simulations to neutralize the net charge of the protein, because it was shown to perform better than standard screened Coulomb canned routines, or to predict ion-binding sites in proteins. This latter is especially true for proteins that are involved in ion transport, because such ions are loosely bound and very difficult to detect experimentally.

Petukh, Marharyta; Zhenirovskyy, Maxim; Li, Chuan; Li, Lin; Wang, Lin; Alexov, Emil



Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier  

Microsoft Academic Search

The 185delAG and 5382insC mutations in the BRCA1 gene and the 6174delT mutation in the BRCA2 gene (the Ashkenazi mutations) have been found to be significantly more common among Jews of eastern European ancestry (1 in 40, 2.5%) in comparison to the general population (1 in 800 to 1 in 300, 0.12–0.33%). Carriers of these mutations, especially the BRCA1 185delAG

Benjamin Piura; Alex Rabinovich; Ilana Yanai-Inbar



Age of Cu(Fe)Au mineralization and thermal evolution of the Punta del Cobre district, Chile  

Microsoft Academic Search

The Punta del Cobre belt is located 15?km south of Copiap?, northern Chile. It comprises several Cu(-Fe)-Au deposits in the\\u000a Punta del Cobre and Ladrillos districts, east of the Copiap? river, and the Ojancos Nuevo district, with the new Candelaria\\u000a mine, and Las Pintadas district, west of the river. The mineralization in the Punta del Cobre belt is characterized by

R. Marschik; B. S. Singer; F. Munizaga; C. Tassinari; R. Moritz; L. Fontboté



Evolució recent del paisatge agrari de l'Alt Empordà a través de la teledetecció i d'índexs paisatgístics  

Microsoft Academic Search

En l'article es presenta el mètode emprat i els resultats obtinguts en l'evolució de les cobertes i usos del sòl extretes d'imatges satèl·lit de vint-i-un municipis de l'Alt Empordà. En concret s'ha quantificat com han evolucionat des del 1977 al 1997 pel que fa a la fragmentació o compactació a través de diversos índexs emprats en l'Ecologia del Paisatge. Els

Xavier Pons i Fernández; Pere Serra; David Saurí i Pujol



The RGD finger of Del-1 is a unique structural feature critical for integrin binding  

SciTech Connect

Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai (Harvard-Med)



Basis for a streamflow forecasting system to Rincón del Bonete and Salto Grande (Uruguay)  

NASA Astrophysics Data System (ADS)

This paper presents the basis for the design of streamflow prediction systems for the hydroelectric dams of Rincón del Bonete (Uruguay) and Salto Grande (Uruguay-Argentina). The prediction is made, independently, for each reservoir and each month of the year with two methodologies: data-driven statistical models and hybrid downscaling that includes atmospheric predictors. We determine a set of potential predictors and then fit linear models coupled with variable selection techniques, under the hypothesis of perfectly known predictors. The predictive skill of the schemes outperforms the climatological forecast throughout the year in both reservoirs (except August in Rincón del Bonete). This remains the case even when the forecast lead does not allow for the use of preceding flows as predictors. While in Rincón del Bonete it is not possible to distinguish a period of high predictability, in Salto Grande, there is a robust signal in March-May and October-December.

Talento, Stefanie; Terra, Rafael



Basis for a streamflow forecasting system to Rincón del Bonete and Salto Grande (Uruguay)  

NASA Astrophysics Data System (ADS)

This paper presents the basis for the design of streamflow prediction systems for the hydroelectric dams of Rincón del Bonete (Uruguay) and Salto Grande (Uruguay-Argentina). The prediction is made, independently, for each reservoir and each month of the year with two methodologies: data-driven statistical models and hybrid downscaling that includes atmospheric predictors. We determine a set of potential predictors and then fit linear models coupled with variable selection techniques, under the hypothesis of perfectly known predictors. The predictive skill of the schemes outperforms the climatological forecast throughout the year in both reservoirs (except August in Rincón del Bonete). This remains the case even when the forecast lead does not allow for the use of preceding flows as predictors. While in Rincón del Bonete it is not possible to distinguish a period of high predictability, in Salto Grande, there is a robust signal in March-May and October-December.

Talento, Stefanie; Terra, Rafael



Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta  

NASA Astrophysics Data System (ADS)

Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

Cirigliano, D.; Vial, J.-C.; Rovira, M.


Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

SciTech Connect

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. We also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.

Wiersma, G.B.; Kohler, A.; Boelcke, C.; Baker, G.; Harmon, M.; Weber, C.; Gonzales, J.



Trichomycetes living in the guts of aquatic insects of Misiones and Tierra del Fuego, Argentina.  


Fourteen species of Trichomycetes living in the guts of aquatic insects are reported from two provinces of Argentina, Misiones and Tierra del Fuego. Twelve of the species belong to the Harpellales and two are Amoebidiales. Five harpellid species are reported from Misiones in the extreme northeast of the country (Genistellospora homothallica, Harpella tica, Smittium culisetae, Smittium sp., Stachylina sp.) and seven are from Tierra del Fuego, the southern tip of South America (H. meridianalis, Glotzia sp., S. culicis, S. cellaspora, S. imitatum, Stachylina minima, Penella simulii). Insect hosts all were immature stages of Culicidae, Simuliidae, Chironomidae, Ceratopogonidae (Insecta: Diptera), and Ephemeroptera and Plecoptera. The lower diversity of Trichomycetes found at Misiones, which has a subtropical climate and rainforest vegetation, was due possibly to the warmer temperatures of the water (15-24 C), compared to the colder streams of Tierra del Fuego (9-15 C), with forests and steppes as typical vegetation. PMID:16396339

López Lastra, Claudia C; Scorsetti, Ana C; Marti, Gerardo A; Coscarón, Sixto


DelsGate: a robust and rapid method for gene deletion.  


Gene deletion is one of the most powerful tools to study gene function. In the genomics era there is great demand for fast, simple high-throughput methods for gene deletion to study the roles of the large numbers of genes that are being identified. Here we present an approach that speeds up the process of generation of deletion mutants by greatly simplifying the production of gene deletion constructs. With this purpose we have developed a method, which we named DelsGate (Deletion via Gateway), that combines PCR and Gateway cloning technology together with the use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. DelsGate consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for the transformation of Ascomycetes and the Basidiomycete fungus Ustilago maydis. The PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. We describe here the entire process, from the generation of the deletion construct with DelsGate to the analysis of the fungal transformants to test for gene replacement, with the Basidiomycete fungus Ustilago maydis. Application of DelsGate to other fungal species is also underway. Additionally, we describe how this basic approach can be adapted to other genetic manipulations with minor changes. We specifically describe its application to create unmarked deletions in Ralstonia solanacearum, a Gram-negative phytopathogenic bacterium. PMID:20238261

García-Pedrajas, María D; Nadal, Marina; Denny, Timothy; Baeza-Montañez, Lourdes; Paz, Zahi; Gold, Scott E



Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations.  


The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ~2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5?MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ~5?MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750-1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ~650 years ago, and into the Iraqi-Jewish community ~450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews. PMID:22763381

Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan



Jasmin i Frederic Mistral, dos models literaris per a Miquel dels Sants Oliver  

Microsoft Academic Search

M. S. Oliver l'any 1903 va publicar al Diario de Barcelona la secció «Literatura extrangera\\u000a», dedicada a l'anàlisi de l'obra d'alguns dels escriptors europeus més notables de l'època.\\u000aLa posició del crític, basada tant en criteris estètics com morals i polítics, s'expressava amb\\u000auna nitidesa absoluta. D'una banda, rebutjava tres tipus de literatura que aleshores tenien un\\u000agran predicament:

Damià Pons i Pons



Gonadal dysgenesis, Turner syndrome with 46,XX,del(18p)3  

SciTech Connect

The authors report a case of a female infant with gonadal dysgenesis, clinical features of Turner syndrome and a de novo del(18p). The factors controlling gonadal dysgenesis and Turner syndrome are unknown to date. The genes involved could be located not only on X chromosome but also on autosomes. The present case suggests that one of these genes is situated on the short arm of chromosome 18. We conclude that patients with del(18p) syndrome should be evaluated for gonadal dysgenesis.

Telvi, L.; Ion, R. [Hopital Saint Vincent de Paul, Paris (France); Bernheim, A. [CNRS, Villejif (France)] [and others



Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos  

NASA Astrophysics Data System (ADS)

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Cellone, S. A.


Aplicación del Teorema de Nekhorochev para tiempos de estabilidad en Mecánica Celeste  

NASA Astrophysics Data System (ADS)

En Mecánica Celeste, uno de los problemas centrales consiste en la determinación de los tiempos de estabilidad. El teorema de Nekhorochev proporciona un método para dicho estudio, para un sistema determinado por un hamiltoniano descripto en las variables acción-ángulo. El trabajo consiste en la acotación tanto del potencial perturbador y de la matriz hessiana del hamiltoniano integrable para determinar luego el tiempo de estabilidad de dicho sistema, donde por estabilidad se entiende la separación en norma infinito en el espacio de las acciones.

Miloni, O.; Núñez, J.; Brunini, A.


A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity  

PubMed Central

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

Chothani, Daya L.; Vaghasiya, H. U.



Do crustal deformations observed by GPS in Tierra del Fuego (Argentina) reflect glacial-isostatic adjustment?  

NASA Astrophysics Data System (ADS)

Vertical site velocities determined by geodetic GPS observations in the Lago Fagnano area, Tierra del Fuego main island, are interpreted with respect to their potential relation with the glacial-isostatic crustal response to ice mass changes. The spatial pattern of the uplift rates, in combination with the horizontal crustal deformation pattern, point towards a fault-tectonic rather than glacial-isostatic origin of the determined vertical crustal deformations. This implies rather small GIA effects pointing towards relatively small Holocene ice-mass changes in Tierra del Fuego. However, these findings are considered to be preliminary. They should be confirmed by additional observations covering an extended area with GPS sites.

Mendoza, L.; Richter, A.; Hormaechea, J. L.; Perdomo, R.; Del Cogliano, D.; Dietrich, R.; Fritsche, M.



Recepción y extensión de las explicaciones metafísicas de los números imaginarios en la España del siglo XIX  

Microsoft Academic Search

1. Preliminares El problema del rigor en Matemáticas puede afrontarse al menos desde dos puntos de vista. El primero, que encontramos sobre todo en las Matemáticas contemporáneas, procede del explosivo desarrollo de esta ciencia durante el Siglo XIX y se distingue sobre todo porque los matemáticos ejercientes son entrenados en ciertas técnicas que en líneas generales se componen de una



Entre metrópolis y periferias. Análisis de los movimientos migratorios a partir del censo de población de 1993  

Microsoft Academic Search

El Área de Demografía y Estudios de Población, del Centro de Investigaciones sobre Dinámica Social –CIDS– de la Universidad Externado de Colombia, definió como objetivo de una de sus Líneas estratégicas de investigación el análisis de los procesos migratorios en Colombia. Aunque la migración constituye un elemento central en la determinación del crecimiento, volumen y composición de la población, este

Alejandro González Pulido; Norma Rubiano



Microsoft Academic Search

Resumen Se plantea una reflexión desde el darwinismo y el psicoanálisis sobre el sentido del sentimiento estético, así como de algunas características del mismo, concluyendo que el sentimiento estético es un tónico de la voluntad imprescindi- ble para vivir con el malestar inherente al hecho de saber que somos seres para la muerte. Palabras clave: Estética, conciencia de sí mismo,

Fabio Rivas Guerrero


Acumulación de tierras, cambio socio-económico y movilidad espacial en los inmigrantes Wolof del bosque de Pata  

Microsoft Academic Search

A través de una migración que han emprendido desde 1978 en el bosque de Pata (sur de Senegal), los Wolof que han venido de Saloum han dado un nuevo giro a su vida. Los beneficios sacados del cultivo de cacahuete, al cual son particularmente apegados, les han permitido hacer varias realizaciones y algunas inversiones. Así, después del refuerzo de medios

Mamady Sidibe



Caracterización de entornos y determinantes de la eficiencia en los sectores del cuero, el calzado y la marroquinería  

Microsoft Academic Search

Este estudio permite caracterizar al sector en Colombia en seis entornos principales e identificar los principales aspectos que marcan la diferenciaentre las empresas de calzado y marroquinería en cuero, ubicadas en el Área Metropolitana del Valle de Aburrá (Amva),1 seleccionadas a partir de una muestra representativa, y comparadas con otras ciudades del país. Adicionalmente, y lo más importante, ayuda a

David Tobón Orozco; Jorge Barrientos Marín


Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.  


CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with previous work, all CHEK2 1100delC mutant tumors clustered among the hormone receptor-positive breast cancers. In the hormone receptor-positive subset, a 40-gene CHEK2 signature was subsequently defined that significantly associated with CHEK2 1100delC breast cancers. The identification of a CHEK2 gene signature implies an unexpected biological homogeneity among the CHEK2 1100delC breast cancers. In addition, all 26 CHEK2 1100delC tumors classified as luminal intrinsic subtype breast cancers, with 8 luminal A and 18 luminal B tumors. This biological make-up of CHEK2 1100delC breast cancers suggests that a relatively limited number of additional susceptibility alleles are involved in the polygenic CHEK2 model. Identification of these as-yet-unknown susceptibility alleles should be aided by clues from the 40-gene CHEK2 signature. PMID:21614566

Nagel, Jord H A; Peeters, Justine K; Smid, Marcel; Sieuwerts, Anieta M; Wasielewski, Marijke; de Weerd, Vanja; Trapman-Jansen, Anita M A C; van den Ouweland, Ans; Brüggenwirth, Hennie; van I Jcken, Wilfred F J; Klijn, Jan G M; van der Spek, Peter J; Foekens, John A; Martens, John W M; Schutte, Mieke; Meijers-Heijboer, Hanne



L'azione del propranololo sulla glicemia e sull'insulina immunoreattiva in una paziente affetta da insulinoma  

Microsoft Academic Search

Riassunto Con la somministrazione orale di propranololo ad una paziente affetta da insulinoma si è notato un miglioramento delle condizioni cliniche e una minor frequenza delle crisi ipoglicemiche. I valori di glicemia e di IRI si sono portati nella norma. Vengono riportati e brevemente discussi i risultati delle prove del digiuno, del glucagone e della leucina praticate prima e durante

Vittorio Neri; Alberto Bartorelli; Giovanni Faglia



Efectos del desajuste educativo sobre el rendimient o de la escolaridad: Un análisis para el caso español  

Microsoft Academic Search

El objetivo del presente estudio es analizar grado de adecuación entre educación y empleo en el mercado de trabajo español, centrándonos principalmente en el fenómeno de la sobreeducación y estudiando sus e fectos sobre los ingresos individuales. Más concretamente, se aborda el estud io del desajuste educativo desde una doble perspectiva: por una parte, se calculan los r endimientos privados

Inés P. Murillo Huertas; Marta Rahona López; Maria del Mar; Salinas Jiménez



Microsoft Academic Search

E n s a y o En este artículo se discuten algunos de los principales aspectos a considerar al momento de abordar el análisis del mercado de los servicios de salud. Las consideraciones conceptuales se refieren tanto a la demanda como a la oferta, aunque el análisis pudiera centrarse en algunos momentos hacia la demanda. Por otra parte, las mismas

Arredondo López; Recaman Mejía


La estructura de mercado del sector de las artes escénicas en España  

Microsoft Academic Search

La diversidad de agentes y de comportamientos, así como la complejidad que encierra la existencia e interrelación de dos mercados, el de la producción y el de la difusión, han dificultado el estudio del sistema escénico español desde perspectivas científicas. Con el objetivo de cubrir parcialmente ese vacío y presentar las especificidades de dicho sistema, el presente trabajo utiliza el





Microsoft Academic Search

La discriminación laboral por raza ha sido un tema ampliamente analizado en la economía del trabajo a partir de la estimación de ecuaciones de ingreso para determinar diferenciales en el salario, pero la influencia de este factor en el acceso a un empleo de calidad no se ha explorado lo suficiente. Realizar este análisis cobra vital importancia para una ciudad




Las fundaciones de ciudades y el pensamiento urbanístico hispano en la era del Descubrimiento  

Microsoft Academic Search

La historia urbana referida al periodo histórico en torno a la fecha de 1492, con sus precedentes, desde la caída de Constantinopla (1452) y su evolución hasta la entronización y asentamiento de la monarquía del Emperador Carlos (~1530), es un periodo excepcional que requiere una reinterpretación a la luz de nuevos enfoques interdisciplinarios y de nuevos descubrimientos científicos. El periodo

María Isabel Navarro Segura



Estudio Comparado de la Tributación del Sector Transporte de Carga en Argentina, Brasil, y Uruguay  

Microsoft Academic Search

En un contexto de creciente integración internacional, caracterizado por la formación de bloques económicos regionales, el sector del transporte de carga cobra cada vez más prominencia. Por ejemplo, el tratamiento tributario conferido al sector por los distintos países participantes de un bloque crea incentivos diferenciados en relación con la ampliación de la integración comercial.

Erika Amorim Araujo




Microsoft Academic Search

La dinámica del prejuicio y el racismo son fenómenos que no necesariamente deben ser estudiados con grandes y complejas escalas tomando grandes muestras de población o en experimentos de laboratorio controlados. Una perspectiva micro-social y etnográfica precisa de 30 minutos y “no intrusiva” no sólo puede ser suficiente metodológicamente en el estudio de estos problemas sino a veces esclarecedora. El

Maximiliano Korstanje




Microsoft Academic Search

El salvaje metropolitano no es sólo un libro de antropología sino además un tratado hermenéutico sobre la filosofía del método que ayuda a los lectores más allá de su disciplina de base a hacer uso de la etnografía en sus trabajos de campo. En base a lo expuesto, Rosana Guber comienza su capítulo introductorio con un análisis sobre las limitaciones

Maximiliano Korstanje




Microsoft Academic Search

He leído con suma atención el trabajo de Korstanje pero tengo que decir, de entrada, que, desafortunadamente, ese trabajo no responde, como su autor cree, al mío. Mi trabajo versa sobre un hecho constatable, no sobre una opinión o sobre una teoría: la ausencia o ignorancia en la literatura del turismo de la función de producción. Como vengo demostrando, el

Francisco Muñoz de Escalona



Cache Valley Virus in the Del Mar VA Peninsula. Ii. Identity of Virus Recovered from Mosquitoes.  

National Technical Information Service (NTIS)

Viruses recovered on the Del Mar Va peninsula from northern salt-marsh mosquitoes Aedes sollicitans and Aedes taeniorhynchus from 1961 through 1964 were shown to be similar to, if not indistinguishable from, Cache Valley virus, and different from Tensaw v...

T. M. Yuill E. L. Buescher



Pedagogia del cos simbòlic. El cos com a valor emergent entre els joves  

Microsoft Academic Search

El artículo aborda desde una perspectiva socio-antropológica el cuerpo humano. Los cambios paradigmáticos sucedidos en disciplinas artísticas así como en el campo de las humanidades permiten una lectura simbólica del cuerpo humano. Es justamente esta dimensión simbólica que nos permite presentarlo como un valor emergente en las identidades de los jóvenes; identidades que pasan por transformar el cuerpo a través

Jordi Planella Ribera



Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells  

PubMed Central

Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF.

Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M.; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W.; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W.; Thomas, David Y.



Boswellia papyrifera (Del.) Hochst: a tropical key species in northern Ethiopia  

Microsoft Academic Search

Boswellia papyrifera (Del.) Hochst is a dryland tree species native to Ethiopia and widely known for its frankincense production. Besides, it has also other numerous environmental, socio-economic, traditional and industrial benefits. However, the population of the species is declining at an alarming rate due to extensive human encroachment. This paper presents the importance of the species, techniques of tapping, harvesting

Kindeya Gebrehiwot; Bart Muys; Mitiku Haile; Ralph Mitloehner


High carrier frequency of the 35delG deafness mutation in European populations  

Microsoft Academic Search

Congenital deafness accounts for about 1 in 1000 infants and approximately 80% of cases are inherited as an autosomal recessive trait. Recently, it has been demonstrated that connexin 26 (GJB2) gene is a major gene for congenital sensorineural deafness. A single mutation (named 35delG) was found in most recessive families and sporadic cases of congenital deafness, among Caucasoids, with relative

Paolo Gasparini; Raquel Rabionet; Guido Barbujani; Salvatore Melchionda; Michael Petersen; Karen Brøndum-Nielsen; Andres Metspalu; Eneli Oitmaa; Marina Pisano; Paolo Fortina; Leopoldo Zelante; Xavier Estivill



Estructura interna y baremación del Test de Pensamiento Creativo de Torrance  

Microsoft Academic Search

Con el presente trabajo se pretende, por una parte, estudiar la estructura interna del TTCT (Torrance Thinking Creative TTCT), y, por otra, establecer los baremos con el fin de poder utilizar el test en el diagnóstico y ambientes educativos. En el trabajo han participado 649 alumnos (319 niñas y 330 ni- ños) cuyas edades oscilan entre 5 y 12 años

Mercedes Ferrando; Carmen Ferrándiz; María Rosario Bermejo; Cristina Sánchez; Joaquín Parra; María Dolores Prieto



Análisis del metabolismo energético y de materiales de Brasil, Chile y Venezuela  

Microsoft Academic Search

El artículo presenta una aplicación de las metodologías de Análisis de Flujo de Materiales y Análisis Integrado Multi- Escala del Metabolismo Social (MSIASM, siglas en inglés) para la caracterización de modelos de desarrollo económico de Brasil, Chile, y Venezuela, mediante la utilización combinada de datos económicos y de uso de energía y materiales para diferentes sectores y en diversos niveles

Nina Eisenmenger; Jesús Ramos Martín; Heinz Schandl




Microsoft Academic Search

El siguiente trabajo responde a un problema que enfrenta el C\\/P Osvaldo Socarrás Martínez, relacionado con las insuficiencias que afectan el desarrollo de la Lengua Materna en los estudiantes, por lo que el objetivo de la misma es el de la elaboración de actividades para favorecer la expresión oral y escrita en los estudiantes del segundo año de técnico medio

Orlando Martínez Cuba; Lisandra Ávila Arzuaga



Natural sinks of CO 2 : Technical synthesis from the palmas Del Mar Workshop  

Microsoft Academic Search

Natural CO2 sinks in terrestrial and marine environments are important components of the global carbon cycle, yet the sign and magnitudes of key fluxes among them are unknown. The results of the Palmas Del Mar Workshop — Natural Sinks of CO2 presented in this special issue and its companion hardbound volume of Water, Air, & Soil Pollution, provide a synthesis

John P. Downing; Dominic A. Cataldo



Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del  

Microsoft Academic Search

In the present study the polyphenolic compound has been isolated from methanol extract of Acacia nilotica Willd. Ex. Del. which has been identified as kaempferol (AN-5) by NMR and mass spectroscopy. The antioxidant potential of the AN-5 was demonstrated in several in vitro assays: measuring the proton radical scavenging activity (DPPH scavenging assay), hydroxyl radical scavenging activity (deoxyribose degradation assay),

Rajbir Singh; Bikram Singh; Sukhpreet Singh; Neeraj Kumar; Subodh Kumar; Saroj Arora




EPA Science Inventory

Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...



Microsoft Academic Search

An analysis of the structure of two short stories by Carmen Martín Gaite: El Castillo de las Tres Murallas and El Pastel del Diablo (The Devil's Cake). These short stories follow the traditional structure of the quest and the journey, but they also propose an interpretatio n from within that reflects and completes the tale.



Nutrición deportiva en la infancia: Cumplimiento de las demandas metabólicas del crecimiento y el ejercicio  

Microsoft Academic Search

ExtractoLos objetivos fundamentales de la infancia son el crecimiento y la maduración óptimos. Estos procesos relacionados con el desarrollo exigen un balance energético y nitrogenado positivo. Aunque la actividad física regular puede intensificar el desarrollo en la infancia, un entrenamiento físico extenuante puede reducir las reservas de energía y nitrógeno del organismo que, entonces, deberán reemplazarse a través de la

C. L. Zanker



Antimicrobial activity of flavonoids in medicinal plants from Taf?? del Valle (Tucumán, Argentina)  

Microsoft Academic Search

Preliminary studies of flavonoids have been realised in five native species from Taf?? del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The

Nancy E. Hernández; M. L. Tereschuk; L. R. Abdala




Microsoft Academic Search

Sommario In questo lavoro viene illustrato uno strumento di modellazione e simulazione multicorpo di roller coaster che si inserisce in una più ampia procedura di progettazione sviluppata per conto di una delle maggiori aziende del settore. Il codice e la metodologia sviluppati investono l'ideazione, il disegno, la simulazione e la verifica funzionale e dinamica di questa particolare tipologia di giostre

C. Braccesi; F. Cianetti; G. Lori


Holocene glaciations in the Ema Glacier valley, Monte Sarmiento Massif, Tierra del Fuego  

Microsoft Academic Search

Investigations carried out in the Ema Glacier valley, Tierra del Fuego, on the eastern side of Monte Sarmiento Massif, enable the recognition of five Holocene glacial events. The oldest glacial advance deposited the so-called external moraines of Ema Glacier, with a probable occurrence between 6000 and 5000 14 C y BP without discarding the potential for these deposits to be from

Jorge Strelin; Gino Casassa; Gunhild Rosqvist; Per Holmlund



Design, Development and Optimization of Highly Efficient Solar Cars: Gato del Sol I-IV  

Microsoft Academic Search

Engineering students at the University of Kentucky have designed and built solar powered cars for the 2008 North American Solar Challenge and the 2009 Formula Sun Grand Prix. Gato del Sol III, our most accomplished car, is powered by a solar array of 480 Silicon monocrystalline photovoltaic cells. Maximum Power Point trackers efficiently made use of these cells and tracked

Raghu Mangu; Krishna Prayaga; Bhavananda Nadimpally; Sam Nicaise




EPA Science Inventory

The reproductive rhythmicity of the false grunion, Colpichthys regis, was observed in the Estero del Soldado, Mexico during October 1982 through January 1983. Spawning runs occurred at approximately 2-week intervals during daytime high tides. These high tides coincided with new a...


Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua  

Microsoft Academic Search

The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation

W. Strauch; E. Talavera; N. Acosta; M. Sanchez; E. Mejia



Impacto Económico en la Salud por Contaminación del Aire en Lima Metropolitana  

Microsoft Academic Search

I. Objetivos y Justificación del Proyecto: La contaminación ambiental es un problema que se ha venido agravando en las ?ltimas décadas en el Perú, sin embargo, en la práctica es poco lo que se ha hecho para reducirla a niveles aceptables o permitidos. A principios de la presente década se han emitido ciertas normas legales que buscan regular los niveles

Juan José Miranda


Las políticas públicas de fomento del reciclaje: La regeneración de aceites usados  

Microsoft Academic Search

Los aceites usados son un residuo peligroso del que pueden derivarse graves daños medioambientales si su gestión es inadecuada; al mismo tiempo, tienen un indudable valor económico, ya que conservan gran parte de los hidrocarburos que los lubricantes contenían originalmente. La gestión de los aceites usados ofrece distintas alternativas, dirigidas principalmente al reciclaje, siendo de destacar la combustión y la

Asunción Arner Güerre; Ramón Barberán Ortí; Jesús Mur Lacambra



Efectos heterogéneos del trabajo infantil en la adquisición de habilidades cognitivas  

Microsoft Academic Search

El estudio se ocupa de los efectos heterogéneos del trabajo en la formación de capital humano a través de una definición amplia de trabajo que incluye toda actividad asociada a responsabilidades no escolares. Dada la variedad de responsabilidades asumidas por niños y adolescentes peruanos, se toma en cuenta dos criterios para clasificar los diferentes tipos de trabajo: el tipo de

Carmen Ponce



Counter-Utopia and Anti-Epic History Writing in Gabriel Miró's El abuelo del rey  

Microsoft Academic Search

In El abuelo del rey (1915) Gabriel Miró tells of the last member of a provincial dynasty, who in the late 1800s travels to the farthest corner of South America expecting to find glory for himself and for his nation. Instead, he ends up working as a petty clerk. In this article, it is argued that through this un-heroic character

Álvaro A. Ayo



Del Bueno Recalls Queso Fresco Casero Cheese Because of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all 16oz. size packages of Queso Fresco Casero Fresh Cheese with a date stamp of Sept 14, 2011 because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious ...



Microsoft Academic Search

Este trabajo se centra en el estudio de la ética en la venta, más concretamente en la importancia que los consumidores conceden a la corrección ética del comportamiento de los vendedores con los que entran en contacto en una relación de compraventa. Lo que se pretende conocer es si la actuación ética de los vendedores en la relación de compraventa

M. A. Revilla Camacho; M. A. Gallego Agueda



Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.  

ERIC Educational Resources Information Center

|A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

Luckie, Jo Ann I.; Bonham, L. Adrianne


Principales resultados del Estudio Nacional de Exámenes de pulmón (NLST): Síntesis

El 4 de noviembre de 2010, el Estudio Nacional de Exámenes de Pulmón dio a conocer resultados iniciales que indican que hubo 20% menos muertes por cáncer de pulmón entre los participantes del estudio evaluados con tomografía computarizada espiral de baja dosis (también conocida como tomografía computarizada helicoidal) que en los participantes que fueron evaluados con radiografías de pecho.


Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).  

ERIC Educational Resources Information Center

This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

Eduplan Informa, 1971




Microsoft Academic Search

Diagnostic investigation on a wild rabbit population in the Serio Park (Bergamo Province, Northern Italy). During the July - September 1997 period, six hundred wild rabbits (Oryctolagus cuniculus) were shot in the Parco del Serio area (Bergamo province, Northern Italy). This action was decided in order to reduce the number of rabbits, considered too high, and to limit the diffusion



33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2013 CFR

...REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area . That portion of the Pacific Ocean lying shoreward of the offshore breakwater and the most seaward 1,000 feet of the entrance channel between the north and...



Biotic association and palaeoenvironmental reconstruction of the “Loma del Pterodaustro” fossil site (Early Cretaceous, Argentina)  

Microsoft Academic Search

A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine LagarcitoFormation at “Loma del Pterodaustro” (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore

Luis Chiappe; David Rivarola; Alberto Cione; Marian Fregenal-Martínez; Héctor Sozzi; Luis Buatois; Oscar Gallego; José Laza; Edgardo Romero; Adriana López-Arbarello; Angela Buscalioni; Claudia Marsicano; Susana Adamonis; Francisco Ortega; Sherri McGehee; Osvaldo Di Iorio



Shed Some Light on the Subject: Teaching Ramon del Valle-Inclan's "Luces de bohemia"  

ERIC Educational Resources Information Center

This essay seeks to provide parallel and interchangeable approaches to teaching Ramon del Valle-Inclan's challenging play "Luces de bohemia". A greater understanding of the cultural and mental frameworks of the early twentieth-century Spanish spectator will permit students to penetrate the dense intertextuality that characterizes Valle's…

Parker, Jason Thomas



Evaluación paramétrica y no paramétrica del desempleo pesquero en Marruecos: Una aplicación para el caso andaluz  

Microsoft Academic Search

RESUMEN El principal objetivo es el análisis de las medidas que las diferentes administraciones pusieron en marcha para reducir las altas tasas de desempleo en la población andaluza afectada por la paralización de la actividad pesquera como consecuencia de la finalización del Acuerdo de Pesca entre la Unión Europea y Marruecos desde el 30 de noviembre de 1999. Mediante la

Encarnación Cordón Lagares; Félix García Ordaz



Rare genotype del2,3\\/2184insA in a cystic fibrosis patient  

Microsoft Academic Search

In this paper we present an interesting case of cystic fibrosis patient with rare genotype del2,3\\/2184insA and atypical clinical image including: mild symptoms in an early phase of disease, quick progress of lung disease, compli- cated with pneumothorax after Bordetella pertussis infection and very good response to systemic and inhaled steroid therapy.

Alina Minarowska; Oksana Kowalczuk; Maciej Kaczmarski; Danuta Kowalczuk


Characterization of Nasal Potential Difference in cftr Knockout and F508del-CFTR Mice  

PubMed Central

Background Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR) defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF). Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (VTE) to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal VTE in CF mice must be well characterized for correct interpretation. Methods We performed VTE measurements in large-scale studies of two mouse models of CF—B6;129 cftr knockout and FVB F508del-CFTR—and their respective wild-type (WT) littermates. We assessed the repeatability of the test for cftr knockout mice and defined cutoff points distinguishing between WT and F508del-CFTR mice. Results We determined the typical VTE values for CF and WT mice and demonstrated the existence of residual CFTR activity in F508del-CFTR mice. We characterized intra-animal variability in B6;129 mice and defined the cutoff points for F508del-CFTR chloride secretion rescue. Hyperpolarization of more than -2.15 mV after perfusion with a low-concentration Cl- solution was considered to indicate a normal response. Conclusions These data will make it possible to interpret changes in nasal VTE in mouse models of CF, in future preclinical studies.

Saussereau, Emilie Lyne; Roussel, Delphine; Diallo, Siradiou; Debarbieux, Laurent; Edelman, Aleksander; Sermet-Gaudelus, Isabelle



Ritrovato per migliorare la qualità della traduzione automatica basato sulla teoria correlazionale del pensiero  

Microsoft Academic Search

In questo articolo l'autore descrive un ritrovato per migliorare la qualità della traduzione automatica i- deato da Silvio Ceccato e basato sulla sua teoria correlazionale del pensiero. Basandosi su esso Ceccato e i suoi collaboratori si dedicarono al problema della traduzione automatica dal 1959 al 1966, compien- do ricerche di tipo quasi esclusivamente teorico. Il progetto fu interrotto quando la

Giulio Benedetti



Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

Microsoft Academic Search

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites.

G. B. Wiersma; A. Kohler; C. Boelcke; G. Baker; M. Harmon; C. Weber; J. Gonzales



El modelo de crecimiento hacia adentro: una interpretación del caso colombiano  

Microsoft Academic Search

En este trabajo se realiza un análisis de los fundamentos teóricos de la CEPAL, haciendo énfasis en las ideas que sobre la industrialización diseñó la institución. Se estudia la forma en que se integran las economías latinoamericanas con el resto del mundo y la manera en que las han afectado las crisis de los años treinta y luego la de

Luis E. Vallejo Zamudio



Aerial Radiometric and Magnetic Survey: Del Rio National Topographic Map, Texas. Final Report.  

National Technical Information Service (NTIS)

The results of analyses of the airborne gamma radiation and total magnetic field survey flown for the region identified as the Del Rio National Topographic Map NH14-7 are presented. The airborne data gathered are reduced by ground computer facilities to y...



Genetics of Suicidal Germination of Striga hermonthica (Del.) Benth by Cotton  

Microsoft Academic Search

of the crop and abandonment of otherwise productive fields (Butler, 1995). Well over a decade ago, a conserva- The germination of giant witchweed (Striga hermonthica (Del.) tive estimate of crop losses due to Striga in Africa was Benth), a noxious root parasite of many cereal crops, is stimulated by exudates from the roots of both host and non-host trap plants.

C. J. Botanga; S. O. Alabi; C. A. Echekwu; S. T. O. Lagoke


Calidad objetiva y su relación con la formación y la satisfacción del empresario: El caso de los alojamientos rurales españoles1  

Microsoft Academic Search

La revisión de la literatura desvela una relación entre el perfil del pequeño empresario y la competitividad del negocio que regenta. A su vez, observamos la progresiva utilización de estándares de calidad en el sector del turismo rural, bien por parte de la Administración o por asociaciones privadas. El desarrollo de estándares se debe a los resultados empresariales positivos que

Rosa María; Hernández Maestro; Pablo A. Muñoz Gallego; Libia Santos Requejo



Microsoft Academic Search

El objetivo del presente documento es mostrar la influencia de la cultura y del perfil cultural, sobre el clima organizacional en las empresas del giro industrial de la Ciudad de México, ubicadas en la Delegación Iztapalapa. Para abordar el estudio de la cultura y el clima organizacional se recurrió al análisis organizacional y al estudio de caso comparativo de medianas




A chemical corrector modifies the channel function of F508del-CFTR.  


The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing the biosynthetic defect in F508del-CFTR, thereby permitting its functional expression at the cell surface. The mechanism of action of chemical correctors remains unclear, but it has been suggested that certain correctors [including 4-cyclohexyloxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-325)] may act to promote trafficking by interacting directly with the mutant protein. To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hydroxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-186)], caused a modest but significant inhibition of cAMP-mediated halide flux. Furthermore, VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR in our ATPase activity assay, an effect that may account for the decrease in channel activity by temperature-rescued F508del-CFTR. These findings suggest that biosynthetic rescue mediated by VRT-325 may be conferred (at least in part) by direct modification of the structure of the mutant protein, leading to a decrease in its ATP-dependent conformational dynamics. Therefore, the challenge for therapy discovery will be the design of small molecules that bind to promote biosynthetic maturation of the major mutant without compromising its activity in vivo. PMID:20501743

Kim Chiaw, Patrick; Wellhauser, Leigh; Huan, Ling Jun; Ramjeesingh, Mohabir; Bear, Christine E



Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.  


Cell cycle checkpoint kinase 2 (CHEK2) gene has been inconsistently associated with colorectal cancer (CRC), particularly the 1100delC variant. To generate large-scale evidence on whether the CHEK2 1100delC variant is associated with CRC susceptibility we have conducted a meta-analysis. Data were collected from the following electronic databases: PubMed, Excerpta Medica Database and Chinese Biomedical Literature Database, with the last report up to November 2010. The odds ratio (OR) and its 95% confidence interval (95% CI) were used to assess the strength of association. We evaluated the contrast of carriers versus non-carriers. Meta-analysis was performed in a fixed/random effect model by using the software Review Manager 4.2. A total of six studies including 4194 cases and 10,010 controls based on the search criteria were involved in this meta-analysis. A significant association of the CHEK2 1100delC variant with unselected CRC was found (OR=2.11, 95% CI=1.41-3.16, P=0.0003). We also found an association of the CHEK2 1100delC variant with familial CRC (OR=2.80, 95% CI=1.74-4.51, P<0.0001). However, the association was not established for sporadic CRC (OR=1.45, 95% CI=0.49-4.30, P=0.50). This meta-analysis demonstrates that the CHEK2 1100delC variant may be an important CRC-predisposing gene, which increases CRC risk. PMID:21807500

Xiang, He-ping; Geng, Xiao-ping; Ge, Wei-wei; Li, He



DelsGate, a robust and rapid gene deletion construction method.  


With the increasing availability of fungal genome sequences there is great demand for fast, simple high-throughput methods to generate constructs for gene deletion. Here we describe a method that combines PCR and Gateway cloning technology together with use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. These constructs are then used to produce deletion mutants in the organism of interest following applicable methods for that species. In establishing this protocol we determined empirically that 1 kb was a suitable flank length to facilitate homologous recombination in our species of interest, Ustilago maydis. The method, which we have named DelsGate (Deletions via Gateway), consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for transformation of Ascomycetes and the Basidiomycete fungus U. maydis which causes corn smut disease. We have tested the reproducibility of the DelsGate approach by generating deletion constructs for 12 U. maydis genes. Although not tested here, the PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. DelsGate has the potential to be universal for all organisms with efficient transformation and homologous recombination systems. PMID:18248826

García-Pedrajas, María D; Nadal, Marina; Kapa, Laura B; Perlin, Michael H; Andrews, David L; Gold, Scott E



Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico  

NASA Astrophysics Data System (ADS)

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la investigacion se utilizo una metodologia cuantitativa y la herramienta para lograrlo fue una encuesta. La encuesta se analizo estadisticamente mediante analisis de frecuencias y por cientos, prueba ANOVA, prueba t, pruebas Post Hoc de Tukey y de Levene. Tambien se realizo nuevamente una prueba de confiabilidad mediante el alfa de Cronbach. Los resultados reflejaron que los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Ciencias Naturales, Educacion, Humanidades, Estudios Generales y el Departamento de Ciencias Biologicas tienen una percepcion muy positiva del concepto de cultura cientifica, los contenidos curriculares de Ciencias Biologicas y del nuevo bachillerato.

Ramos Pastrana, Nilsa


Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1  

PubMed Central

Misfolding and degradation of CFTR is the cause of disease in patients with the most prevalent CFTR mutation, an in-frame deletion of phenylalanine (F508del), located in the first nucleotide-binding domain of human CFTR (hNBD1). Studies of (F508del)CFTR cellular folding suggest that both intra- and inter-domain folding is impaired. (F508del)CFTR is a temperature-sensitive mutant, that is, lowering growth temperature, improves both export, and plasma membrane residence times. Yet, paradoxically, F508del does not alter the fold of isolated hNBD1 nor did it seem to perturb its unfolding transition in previous isothermal chemical denaturation studies. We therefore studied the in vitro thermal unfolding of matched hNBD1 constructs ±F508del to shed light on the defective folding mechanism and the basis for the thermal instability of (F508del)CFTR. Using primarily differential scanning calorimetry (DSC) and circular dichroism, we show for all hNBD1 pairs studied, that F508del lowers the unfolding transition temperature (Tm) by 6–7°C and that unfolding occurs via a kinetically-controlled, irreversible transition in isolated monomers. A thermal unfolding mechanism is derived from nonlinear least squares fitting of comprehensive DSC data sets. All data are consistent with a simple three-state thermal unfolding mechanism for hNBD1 ± F508del: N(±MgATP) ? IT(±MgATP) ? AT ? (AT)n. The equilibrium unfolding to intermediate, IT, is followed by the rate-determining, irreversible formation of a partially folded, aggregation-prone, monomeric state, AT, for which aggregation to (AT)n and further unfolding occur with no detectable heat change. Fitted parameters indicate that F508del thermodynamically destabilizes the native state, N, and accelerates the formation of AT.

Protasevich, Irina; Yang, Zhengrong; Wang, Chi; Atwell, Shane; Zhao, Xun; Emtage, Spencer; Wetmore, Diana; Hunt, John F; Brouillette, Christie G



CHEK2*1100delC homozygosity in the Netherlands-prevalence and risk of breast and lung cancer.  


The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency.European Journal of Human Genetics advance online publication, 8 May 2013; doi:10.1038/ejhg.2013.85. PMID:23652375

Huijts, Petra Ea; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly Mm; Wijnen, Juul; Berns, Els Mjj; Martens, John Wm; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob Aem; Devilee, Peter; van Asperen, Christi J



Genetic counseling for susceptibility loci and neurodevelopmental disorders: The del15q11.2 as an example.  


In recent years, several recurrent copy number variations (CNVs) that confer risk of neurodevelopmental disorders have been identified (e.g., del and dup 16p11.2, del15q13.3, del and dup 1q21.1, del16p13.3, del15q11.2). They are often inherited from an unaffected parent and lack phenotypic specificity. Although there is growing evidence from association studies to consider them as susceptibility CNVs, their clinical utility is debated. Yet the clinician is frequently challenged to deal with these counseling situations without guidelines or consensus. In this report, counseling issues and research opportunities are discussed, with the recurrent 15q11.2 BP1-BP2 (including CYFIP1, NIPA1, NIPA2, TUBGCP5) as an example. Several clinical reports have been published describing patients with del15q11.2 featuring intellectual disability, developmental delay, neurological problems, autism spectrum disorder (ASD), attention problems, speech delay, and dysmorphism. The del15q11.2 was found to be significantly associated with intellectual disability, schizophrenia, epilepsy, and ASD. In this report we discuss how patient-specific and family-specific information may alter the interpretation of del15q11.2 as a contributing factor to the disorder in practical counseling situations. In addition, an association study for ASD in a Belgian Flemish cohort and an overview of reported association studies, clinical reports and genomics data for del15q11.2 are presented. © 2013 Wiley Periodicals, Inc. PMID:24123946

De Wolf, Veerle; Brison, Nathalie; Devriendt, Koenraad; Peeters, Hilde



Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.  


Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa. PMID:22972202

Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian



Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997-1999.  


Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain). This is the first time that a molecular analysis was performed for the E. granulosus isolates from Tierra del Fuego. PMID:16504405

Zanini, Fabián; Gonzalo, Roberto; Pérez, Héctor; Aparici, Inés; Soto, Ximena; Guerrero, Juvenal; Cerrone, Gloria; Elissondo, Celina




Microsoft Academic Search

Este trabajo busca contribuir a la discusión sobre el proceso de expansión del estado Inka hacia las áreas periféricas del sur de los Andes, particularmente en los valles costeros Lluta y Azapa del extremo norte de Chile. Este proceso es analizado explorando el rol del arte rupestre -como soporte material de transmisión de ideología- en el proceso de integración que

Daniela Valenzuela; Calogero M. Santoro; Álvaro Romero



The 'Del'fin' high-power laser facility for heating spherical thermonuclear targets  

NASA Astrophysics Data System (ADS)

A review is presented of the 12-channel Del'fin laser fusion system for the high-temperature heating of thermonuclear targets in spherical irradiation geometry. Del'fin consists of a neodymium laser (with limit output energy of 10 kJ, pulse duration of 0.1-1.0 nsec, and radiation divergence of 0.0005 rad), a vacuum chamber for the laser-plasma interaction, and diagnostic probes for laser and plasma. Particular consideration is given to the focusing system which makes it possible to achieve a high degree of symmetry of spherical irradiation for maximum flux densities at the target surface (10 to the 15th W/sq cm). The problem of maximizing spherical target heating in the laser fusion system is considered.

Basov, N. G.; Bykovskii, N. E.; Danilov, A. E.; Kalashnikov, M. P.; Krokhin, O. N.; Kruglov, B. V.; Mikhailov, Iu. A.; Osetrov, V. P.; Pletnev, N. V.; Rode, A. V.



History and use of del Nido cardioplegia solution at Boston Children's Hospital.  


Cardioplegia is an integral and essential method of myocardial protection for patients of all ages requiring cardiac surgery in which the heart must be stopped. Numerous cardioplegia solutions and delivery methods have been developed. The del Nido cardioplegia solution has been in use for 18 years at Boston Children's Hospital. This is a unique four parts crystalloid to one part whole blood formulation that is generally used in a single-dose fashion. Although the formulation was originally developed for use in pediatric and infant patients, its use for adult cardiac surgery has been expanding. National and international inquiries to our institution regarding this cardioplegia have been increasing over the last 2 years. We present the developmental history, supporting theory, and current protocol for use of what is now referred to as del Nido cardioplegia. PMID:23198389

Matte, Gregory S; del Nido, Pedro J



Detection of super-soft emission in nova V339 Del  

NASA Astrophysics Data System (ADS)

Swift has been regularly observing the fourth LAT-detected classical nova (ATEL #5302) V339 Del (Nova Del 2013; PNV J20233073+2046041) since its outburst on 2013 August 14. Once optical loading had been correctly accounted for (ATel #5429), a real X-ray source was first detected on September 19. The XRT 0.3-10 keV X-ray count rate has been slowly rising since this time, from a value of (1.8 +0.7/-0.6)x10-3 count s-1 on September 19 to (7 +/- 2)x10-3 count s-1 on October 8 [these count rates are from grade 0 (single pixel) events only, to mitigate any residual optical loading effects].

Page, K. L.; Osborne, J. P.; Kuin, N. P. M.; Woodward, C. E.; Schwarz, G. J.; Starrfield, S.; Shore, S. N.; Walter, F. M.



Seismic stratigraphic analysis of the Punta del Este basin, offshore Uruguay, South America  

SciTech Connect

The Punta del Este part of the greater Salado basin is relatively unexplored with only two wells having been drilled, both in the updip part of the basin. These two wells have contributed some understanding of the stratigraphic succession but have failed to adequately assess the basin's true hydrocarbon potential. This paper constitutes one of the first detailed, comprehensive published accounts of this basin and is a prerequisite for future exploration in the area. In this paper, the authors give the results and major conclusions of a regional seismic stratigraphic analysis of the Punta del Este basin, offshore Uruguay. This paper is one of the first detailed, comprehensive published accounts of the tectonic and sedimentary evolution of this basin. The study area covers approximately 15,000 km{sup 2} (5,790 mi{sup 2}) of the continental shelf, from the shoreline to the 200-m (655-ft) shelf isobath.

Stoakes, F.A.; Campbell, C.V. (Stoakes Campbell Geoconsulting Ltd., Calgary, Alberta (Canada)); Cass, R. (Arvec Consulting Ltd., Calgary, Alberta (Canada)); Ucha, N. (ANCAP, Montivideo (Uruguay))



From badge of pride to cause of stigma: combatting mal del pinto in Mexico.  


Mal del pinto is a dermatological disease characterized by discoloured patches of skin on the face and body. It has been present in what is now the territory of Mexico from before the Spanish conquest up to recent times. Though early concerns for mal del pinto as a public health problem can be traced back to the late 19th century, no campaign to combat the disease was undertaken until the second half of the 20th. Thanks to the effectiveness of treatment with penicillin, the fight against this illness--which was once assumed as a symbol of pride--enjoyed a broader acceptance among the population that other health campaigns. PMID:23332859

Carrillo, Ana María



Down and Turner syndromes in a female infant with 47,X,del(X)(p11),+21  

Microsoft Academic Search

This report describes a female infant with a 47,X,del(X)(p11),+21 karyotype who has clinical features of both Down and Turner syndromes. The majority of her clinical features are suggestive of Down syndrome.

John T. Martsolf; M. Ray; Fred Bauder; Rod Boychuk; J. D. Armstrong



75 FR 39668 - Notice of Availability of Final Environmental Impact Statement for the Proposed Rio del Oro...  

Federal Register 2010, 2011, 2012, 2013

...Rio del Oro Specific Plan Project, in Sacramento County, CA, Corps Permit Application...Army Corps of Engineers (USACE), Sacramento District has prepared a Final Environmental...use development within south-eastern Sacramento County. On December 8, 2006,...



Phase II, Final Project Report, Paso del Norte Watershed Council, Coordinated Water Resources Database, and GIS Project.  

National Technical Information Service (NTIS)

The Coordinated Water Resources Database and GIS Project was developed to provide improved access to regional water resources data in the Paso del Norte region for regional water stakeholders to make timely decisions in water operations and flood control....

C. Brown M. Bourdon Z. Sheng



A history of 'uel': From Latin to Castilian \\/ Una història de 'uel': Del llatí al castellà  

Microsoft Academic Search

Centrant-nos específicament en les evidències procedents de la Península Ibèrica,\\u000aen aquest article s'hi traça la història de la partícula disjuntiva llatina 'uel';, del\\u000aseu ús en llatí clàssic a la seva eventual desaparició en romanç. S'hi estudien\\u000ales semblances entre el llatí i el romanç, i s'hi prova que tot i que encara es pot\\u000aaprendre molt concentrant-nos només

Neil Allies



La externalizacion del trabajo agrario y las empresas de servicios a la agricultura  

Microsoft Academic Search

Resumen: En este art�culo se analiza el proceso de externalizaci�n de las labores agrarias y el consiguiente desarrollo de una agricultura terciarizada. La fragmentada dimensi�n laboral y econ�mica de las explotaciones agrarias determina el proceso de externalizaci�n de las tareas agrarias en la medida en que no permite ni la incorporaci�n de innovaciones que exige el desarrollo del sistema alimentario

Alicia Langreo Navarro; Sociedad de Estudios



Patrones alimenticios y valoración del estado nutricional en población adulta atendida en la Atención Primaria  

Microsoft Academic Search

INTRODUCCIÓN: Los patrones alimenticios influyen en la salud del momento y pueden determinarla a largo plazo.\\u000aOBJETIVOS: Identificar los hábitos alimenticios y el estado nutricional de la población entre 18 y 44 años de edad atendida en un centro de atención primaria y estudiar los factores asociados.\\u000aTIPO DE ESTUDIO: Transversal.\\u000aEMPLAZAMIENTO: Área básica urbana.\\u000aSUJETOS: Muestra aleatoria de 201

Matilde González Solanellas; Marta Puig Soler; Ana Romagosa Perez-Portabella; Clàudia Caselles Montagut; Montserrat Grau Carod; Hegoi Segurola Gurrutxaga; Santiago Lancho Lancho; Edurne Zabaleta del Olmo



Pasado, presente y futuro de las dimensiones pública y social en el desarrollo conceptual del marketing  

Microsoft Academic Search

Resumen  Bien sabido es lo conveniente que resulta delimitar conceptual y metodológicamente un fenómeno o circunstancia antes de proceder\\u000a a su estudio, afirmación que cobra pleno sentido si a lo que se está haciendo referencia es a las dimensiones páblica y social\\u000a del marketing. A partir de dicho planteamiento, en el presente trabajo se lleva a cabo un análisis de la

José Luis Vézquez Burguete



The cyclic hierarchy of the 'Purbeckian' Sierra del Pozo Section, Lower Cretaceous (Berriasian), southern Spain  

Microsoft Academic Search

The lowermost Cretaceous (Berriasian) Sierra del Pozo Formation is divisible into metre-scale cycles that are bundled in a four-tiered hierarchy of cycles and cyclic sequences. At the smallest scale, sixth-order cycles, thought to be the product of precessionally forced sea-level fluctuations (c. 20 ka), average less than a metre in thickness, shallow upward and are bounded by surfaces where deeper




Optimización mediante algoritmos genéticos de la gestión del agua en el regadío  

Microsoft Academic Search

El uso de un recurso como el agua, esencial y escaso, tiene gran trascendencia ambiental, social, económica,\\u000apolítica, etc., siendo su adecuada gestión fundamental para conseguir la sostenibilidad de sus aprovechamientos.\\u000aPara alcanzar ese objetivo, la agricultura actual necesita modelos de ayuda a la toma de decisiones para\\u000ala gestión y explotación agrícola.\\u000aSe presenta un modelo de optimización del

Pedro Carrión; Eulogio López; José Fernando Ortega; Arturo de Juan



Challenges of modeling current very large lahars at Nevado del Huila Volcano, Colombia  

Microsoft Academic Search

Nevado del Huila, a glacier-covered volcano in the South of Colombia’s Cordillera Central, had not experienced any historical\\u000a eruptions before 2007. In 2007 and 2008, the volcano erupted with phreatic and phreatomagmatic events which produced lahars\\u000a with flow volumes of up to about 300 million m3 causing severe damage to infrastructure and loss of lives. The magnitude of these lahars

Raphael Worni; Christian Huggel; M. Stoffel; B. Pulgarín


Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.


The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study  

Microsoft Academic Search

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC).\\u000a Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data\\u000a from a total of 7,753

Bernd Frank; Sushila H. Rigas; Justo Lorenzo Bermejo; Miriam Wiestler; Kerstin Wagner; Kari Hemminki; Malcolm W. Reed; Christian Sutter; Barbara Wappenschmidt; Sabapathy P. Balasubramanian; Alfons Meindl; Marion Kiechle; Peter Bugert; Rita K. Schmutzler; Claus R. Bartram; Christina Justenhoven; Yon-Dschun Ko; Thomas Brüning; Hiltrud Brauch; Ute Hamann; Paul P. D. Pharoah; Alison M. Dunning; Karen A. Pooley; Douglas F. Easton; Angela Cox; Barbara Burwinkel



The distribution and regeneration of Boswellia papyrifera (Del.) Hochst. in Eritrea  

Microsoft Academic Search

Boswellia papyrifera (Del.) Hochst. is a deciduous gum-producing multipurpose perennial tree species growing in Sudanian and Sahelian regions. The tree is tapped on the stem for oleo-gum called olibanum (true frankincense). Land clearing for agriculture and un-regulated grazing are threatening the future of the natural Boswellia woodlands in Eritrea. Against this background, a study was carried out to investigate the

Ogbazghi Woldeselassie



Physical, morphological and chemical characteristics, oil recovery and fatty acid composition of Balanites aegyptiaca Del. kernels  

Microsoft Academic Search

Balanites aegyptiaca Del. kernels were chemically,physically and morphologically characterized. Crude oil (49.0%) andcrude protein (32.4%) were the two major constituents of the kernels.Phytic acid content was relatively high compared to other legumes. Incontrast, antitryptic activities of the kernel flours were very low.Sapogenin contents of the full fat, defatted and testa flours were 1.5, 2.7and 3.0%, respectively. The hardness of the

A. M. Mohamed; W. Wolf; W. E. L. Spieß



GIS based Relative Tsunami Hazard Maps for Northern California, Humboldt and Del Norte Counties  

Microsoft Academic Search

Tsunami hazard maps are generated using a geographical information systems (GIS) approach to depict the relative tsunami hazard of coastal Humboldt and Del Norte Counties in northern California. Maps are composed for the Humboldt Bay, Eel River, and Crescent City regions and available online at http:\\/\\/\\/~geodept\\/earthquakes\\/rctwg\\/toc.html . In contrast to previous mapping efforts that utilize a single line to represent

J. R. Patton; L. A. Dengler



CHEK2 1100delC and polygenic susceptibility to breast cancer and colorectal cancer  

Microsoft Academic Search

Approximately 15-25% of breast cancers are identified in women with a family history of breast cancer. Yet, germline mutations in the currently known breast cancer susceptibility genes account for only one-third of familial breast cancer cases. In 2002, our research group had identified the CHEK2 1100delC mutation as a breast cancer susceptibility allele. It was estimated that this mutation confers

M. Wasielewski



Antimicrobial activity of flavonoids in medicinal plants from Tafí del Valle (Tucumán, Argentina).  


Preliminary studies of flavonoids have been realised in five native species from Tafí del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The total extracts of flavonoids of each plant were tested and four species studied showed antimicrobial activity. PMID:11025172

Hernández, N E; Tereschuk, M L; Abdala, L R



Urban agriculture, poverty alleviation, and gender in Villa María del Triunfo, Peru  

Microsoft Academic Search

This chapter describes gender mainstreaming in the multi-stakeholder action- planning process (MPAP) in the district of Villa María del Triunfo, which began in 2005. It refl ects the inclusion of a gender perspective in every stage of the process developed, and the project's contribution to promoting gender equity in urban agriculture. The multi-stakeholder action-planning process was conceived in the city

Noemí Soto; Gunther Merzthal; Maribel Ordoñez; Milagros Touzet


Growth patterns of Nothofagus pumilio trees along altitudinal gradients in Tierra del Fuego, Argentina  

Microsoft Academic Search

The influence of ecological factors resulting from altitude on growth characteristics of Nothofagus pumilio was analyzed. N. pumilio forests grow in the southern Andes from near sea level to 600 m.a.s.l. Eight study sites were selected in the southwestern\\u000a area of Tierra del Fuego, on north- and south-facing slopes, and distributed along an altitudinal gradient (200–600 m.a.s.l.).\\u000a Growth cycles throughout

Guillermina Massaccesi; Fidel A. Roig; Guillermo J. Martínez Pastur; Marcelo D. Barrera



Mössbauer study of archaeological ceramics from Valle del Alto Sinu (Colombia)  

NASA Astrophysics Data System (ADS)

A physico-chemical characterization of ceramic samples from the arachaeological sites of El Cabrero, El Gallo, and El Frasquillo (Valle del Alto Sinú) is presented. Extensive use of Mössbauer spectroscopy data reveals that the currently used typological classification scheme of Dolmatoff is related to the production technology of the different artifacts. In addition, a model for firing conditions for “Rojo Sencillo”, “Tierra Impresa”, “Tierra Incisa”, and “Blanco” types of ceramics is proposed.

Useche, L. A.; Gaviria, S.; Alabart, J. R.; Fontcuberta, J.



Lack of founding Amerindian mitochondrial DNA lineages in extinct aborigines from Tierra del Fuego-Patagonia  

Microsoft Academic Search

Ancient DNA from bones and teeth of 60 individuals from four extinct human populations from Tierra del Fuego-Patagonia (Selknam, Yamana, Kaweskar and Aonikenk) has been extracted and the mitochondrial DNA (mtDNA) amplified by using the polymerase chain reaction. High-resolution analysis of endonuclease restriction site variation in the mtDNA and sequencing of its hypervariable non-coding control region, revealed complete absence of

Carles Lalueza; Alejandro Pérez-Pérez; Eva Prats; Lluís Cornudella; Daniel Turbón



Groundwater flow modelling of the regional aquifer of the Pampa del Tamarugal, northern Chile  

Microsoft Academic Search

The Pampa del Tamarugal Aquifer (PTA) is an important source of groundwater in northern Chile. In this study, a groundwater\\u000a flow model of this aquifer is developed and calibrated for the period 1983–2004. The model reproduces the observed flow-field\\u000a and the water balance components reasonably well. Five scenarios are defined to evaluate the response to different pumping\\u000a situations. These scenarios

Rodrigo Rojas; Alain Dassargues



A sole del(15q) anomaly in post-myelodysplasia acute myeloid leukemia  

Microsoft Academic Search

We report the second case of post-myelodysplasia acute myeloid leukemia (post-MDS AML) with a sole chromosome change del(15q). This anomaly is rarely seen. To our knowledge, only seven cases so far have been reported in human neoplasias, including one case each of acute myeloid leukemia (AML), acute lymphoid leukemia, post myelodysplasia AML, myelodysplastic syndrome, myelofibrosis, macroglobulinemia, Hodgkin's lymphoma and uterine

Naoyuki Yahata; Kazuma Ohyashiki; Osamu Iwase; Yukihiko Kimura; Atsushi Kodama; Katsuyski Fukutake; Keisuke Toyama



Metabolismo di cellule adipose umane isolate in vitro. I. Effetto del glucosio e dell'Insulina  

Microsoft Academic Search

Riassunto L'insulina stimola l'incorporazione dell' 114C del glucosio nel CO2 prodotto da cellule adipose umane isolatein vitro. Tale effetto sembra essere evidente solo con concentrazioni abbastanza elevate dell'ormone, nelle condizioni sperimentali descritte nel presente lavoro. Analogamente, anche l'effetto antilipolitico dell'insulina è evidenziabile, in modesta entità, solo con concentrazioni relativamente elevate dell'ormone nelmedium di incubazione. La presenza di glucosio nelmedium di

Guido Pozza; Alberto Ghidoni; Edda Sanesi; Augusta Pappalettera; Angela Tognetti



Studio degli anticorpi anti-insulina del siero umano in soggetti normali e diabetici  

Microsoft Academic Search

Riassunto Vengono presentati i risultati ottenuti con l'impiego di una metodica di semplice esecuzione per la ricerca di anticorpi anti-insulina, basata sull'impiego di insulina I125 o I131 e sulla successiva precipitazione con alcool assoluto del complesso antigene-anticorpo. Gli anticorpi anti-insulina sono stati riscontrati con grande frequenza solo in pazienti diabetici già sottoposti a trattamento insulinico. Un elevato titolo di anticorpi

Alberto Ghidoni; Giuseppe Sorgato; Edda Sanesi; Guido Pozza



Paleomagnetism and 40Ar\\/39Ar Chronology of Lavas from Meseta del Lago Buenos Aires, Patagonia  

Microsoft Academic Search

As part of a larger project investigating paleosecular variation in South America, 36 paleomagnetic and geochronology sites were sampled on Meseta del Lago Buenos Aires (47°S, 289°E), 200 km east of the active plate boundary in southern Patagonia. Basaltic lavas sampled range from late Miocene to late Pleistocene yet most of the individual lavas are younger than 3.3 Ma. Thirty-eight

Laurie L. Brown; Brad S. Singer; Matthew L. Gorring



Ricerche sull’azione del campo magnetico terrestre sopra i corpuscoli della radiazione penetrante  

Microsoft Academic Search

\\u000a Sunto  Se la radiazione penetrante giunge al limite dell’atmosfera come una radiazione corpuscolare avente un’energia di alcuni miliardi\\u000a di volt-elettrone, il campo magnetico terrestre dovrebbe dar luogo ad una forte dissimetria nella sua distribuzione di intensità\\u000a rispetto al piano del meridiano magnetico. L’esperiema eseguita per mettere in evidenza questa dissimetria ha dato esito negativo.

Bruno Rossi



Chemostratigraphy of the Lower Arroyo del Soldado Group (Vendian, Uruguay) and Palaeoclimatic Implications  

Microsoft Academic Search

New C- and O-isotopic determinations from the Vendian lower Arroyo del Soldado Group are reported and combined with sedimentologic and biostratigraphic data. On the basis of different geochemical and petrographic criteria, the primary nature of the C- and Sr-isotopic signature is shown. Positive d13C-values characterize the mainly siliciclastic upper Yerbal Formation, which contains oxide-facies BIF and a diverse assemblage of

Claudio Gaucher; Alcides Nóbrega Sial; Gonzalo Blanco; Peter Sprechmann



The Icelandic founder mutation BRCA2 999del5: analysis of expression  

Microsoft Academic Search

INTRODUCTION: A founder mutation in the BRCA2 gene (BRCA2 999del5) accounts for 7–8% of female breast cancers and for 40% of male breast cancers in Iceland. If expressed, the mutant gene would encode a protein consisting of the first 256 amino acids of the BRCA2 protein. The purpose of this study was to determine whether this mutant protein is produced

Evgenia K Mikaelsdottir; Sigridur Valgeirsdottir; Jorunn E Eyfjord; Thorunn Rafnar



Sul problema del cambiamento di variabili nella teoria delle distribuzioni (II)  

Microsoft Academic Search

Riassunto  Si espongono nuove considerazioni relative al problema del cambiamento di variabili nella teoria delle distribuzioni, in aggiunta\\u000a a quelle svolte in un nostro precedente lavoro. Nel primo numero si tratterà il problema della derivazione delle distribuzioni\\u000a trasformate in analogia al teorema classico sulla derivazione delle funzioni composte. Nei numeri successivi si tratterà soprattutto\\u000a della estensione, al caso di più variabili,

S. Albertoni; M. Cugiani



SPInDel: a multifunctional workbench for species identification using insertion/deletion variants.  


The majority of the available methods for the molecular identification of species use pairwise sequence divergences between the query and reference sequences (DNA barcoding). The presence of multiple insertions and deletions (indels) in the target genomic regions is generally regarded as a problem, as it introduces ambiguities in sequence alignments. However, we have recently shown that a high level of species discrimination is attainable in all taxa of life simply by considering the length of hypervariable regions defined by indel variants. Each species is tagged with a numeric profile of fragment lengths-a true numeric barcode. In this study, we describe a multifunctional computational workbench (named SPInDel for SPecies Identification by Insertions/Deletions) to assist researchers using variable-length DNA sequences, and we demonstrate its applicability in molecular ecology. The SPInDel workbench provides a step-by-step environment for the alignment of target sequences, selection of informative hypervariable regions, design of PCR primers and the statistical validation of the species-identification process. In our test data sets, we were able to discriminate all species from two genera of frogs (Ansonia and Leptobrachium) inhabiting lowland rainforests and mountain regions of South-East Asia and species from the most common genus of coral reef fishes (Apogon). Our method can complement conventional DNA barcoding systems when indels are common (e.g. in rRNA genes) without the required step of DNA sequencing. The executable files, source code, documentation and test data sets are freely available at PMID:22978681

Carneiro, João; Pereira, Filipe; Amorim, António



Simulación numérica del transporte iónico en electrodeposición en condiciones más realísticas  

Microsoft Academic Search

El fenómeno de deposición electroquímica ramificada (ECD) en celdas delgadas presenta dos escalas que\\u000adifieren notablemente: una zona de casi neutralidad que ocupa la mayor parte del espacio y una capa límite\\u000ade carga varios órdenes de magnitud menor a aquélla. En la capa límite se produce la mayor parte de la\\u000acaída de potencial y de las variaciones de

Guillermo Santiago; Alejandro Peuriot; Guillermo Marshall; Fernando Molina



Dysmorphic Villi Mimicking Partial Mole in a Case with del(18)(q21)  

Microsoft Academic Search

In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies,

Dinesh Rakheja; Kathleen S. Wilson; Beverly B. Rogers



Germline BRCA1 185delAG mutations in Jewish women with breast cancer  

Microsoft Academic Search

SummaryBackground We aimed to find out the proportion of breast cancers in Ashkenazi Jewish women attributable to the frameshift mutation at position 185 involving the deletion of adenine and guanine (185delAG) in the breast cancer gene BRCA1.Methods We studied 107 Ashkenazi Jewish women with breast cancer seen at medical oncology and genetic counselling clinics in New York over a three

K Offit; P McGuire; A Schluger; H Hampel; K Brown; T Gilewski; L Norton; J Swensen; S Neuhausen; M Skolnick; D Goldgar



El nou cremallera de Montserrat (1): significarà la recuperació del ferrocarril més popular de Catalunya  

Microsoft Academic Search

L'article recull, en aquesta primera part, els antecedents històrics del cremallera de Montserrat fons al replantejament de la necessitat de reinstaurar aquest transport públic després de la seva clausura el 1957. S'hi presenten les alternatives que es van estudiar prèviament a l'adopció d'un nou sistema de cremallera que permetrà alhora serveis directes amb unes altres poblacions de Catalunya.

Carles Salmeron i Bosch



Atmospheric background trace elements deposition in Tierra del Fuego region (Patagonia, Argentina), using transplanted Usnea barbata lichens  

Microsoft Academic Search

Lichen, Usnea barbata, transplants taken from Tierra del Fuego (south Patagonia, Argentina) were tested as potential biomonitors of atmospheric\\u000a airborne deposition in an apparently pristine environment. In 2005, lichens were sampled in a reference site (n?=?31) and transplanted in the northern Region of Tierra del Fuego. After, respectively, 1 month and 1 year of exposure, we\\u000a collected them. The aim of the

Marcelo Enrique Conti; Maria Grazia Finoia; Beatrice Bocca; Giustino Mele; Alessandro Alimonti; Anna Pino


DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness*  

PubMed Central

Previously, both primary and secondary anti-D alloimmunizations induced by “Asian type” DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi’an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The “Asian type” DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR).

Shao, Chao-peng; Wang, Bao-yan; Ye, Shi-hui; Zhang, Wen-li; Xu, Hua; Zhuang, Nai-bao; Wu, Xiao-ying; Xu, Heng-gui



Frequency of the CHEK2 1100delC Mutation among Women with Breast Cancer: An International Study  

Microsoft Academic Search

A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranean. The frequency of the 1100delC allele has not been

Shiyu Zhang; Catherine M. Phelan; Phil Zhang; Francois Rousseau; Parviz Ghadirian; William Foulkes; Nancy Hamel; David McCready; Maureen Trudeau; Henry Lynch; Douglas Horsman; Zeba Aziz; Magda Gomes; Mauricio Magalhaes Costa; Alexander Liede; Aletta Poll; Ping Sun; Steven A. Narod


Frequency of CHEK2*1100delC in New York breast cancer cases and controls  

Microsoft Academic Search

BACKGROUND: The 1100delC CHEK2 allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear. METHODS: We genotyped 1665 healthy New York

Kenneth Offit; Heather Pierce; Tomas Kirchhoff; Prema Kolachana; Beth Rapaport; Peter Gregersen; Steven Johnson; Orit Yossepowitch; Helen Huang; Jaya Satagopan; Mark Robson; Lauren Scheuer; Khedoudja Nafa; Nathan Ellis



Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama  

USGS Publications Warehouse

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

Lovelock, C. E.; Feller, I. C.; McKee, K. L.; Thompson, R.



Campano-Maastrichtian foraminifera from onshore sediments in the Rio del Rey Basin, Southwest Cameroon  

NASA Astrophysics Data System (ADS)

Campanian-Maastrichtian marine sediments outcrop in five genetically linked sedimentary basins along the West African coast in the Gulf of Guinea, from the Douala Basin in Cameroon to the Anambra Basin in Nigeria. These sediments in the more centrally located Rio del Rey Basin have been the least studied. Therefore, the geologic history of this region has merely been speculative. The Rio del Rey Basin like the adjacent Niger Delta is producing hydrocarbon from the offshore Tertiary sedimentary interval in which all studies have been focused, neglecting the onshore Cretaceous sediments. Outcrops in the basin are rare, small and highly weathered. Samples from some of these sediments have yielded a few Planktonic and dominantly benthonic foraminiferal assemblages. The long-ranging heterohelix and hedbergellids characterized the planktics while the species Afrobolivina afra which is a well known diagnostic taxon for Campanian-Maastrichtian sediments in West African basins clearly dominate the benthic assemblage. Its occurrence in association with other Upper Cretaceous forms such as Bolivina explicata, Praebulimina exiqua, Gabonita lata, Ammobaculites coprolithiformis amongst others, formed the basis on which this age was assigned to the sediments sampled from the Rio del Rey Basin. Hence, this work has undoubtedly established the much needed link in this regional geologic history and correlates these sediments with the Logbaba and Nkporo Formations in the Douala Basin in Cameroon and the southeastern Nigerian Sedimentary Basins. Thus, these units were all deposited during this same geologic period and probably controlled by the same geologic event.

Njoh, Oliver Anoh; Victor, Obiosio; Christopher, Agyingi



CASP-8 -652 6N ins/del polymorphism and cancer risk: A literature-based systematic HuGE review and meta-analysis  

PubMed Central

Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 ?652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancers. However, the overall reported studies have shown inconsistent conclusions. In this human genome epidemiology (HuGE) review and meta-analysis, the aim was to identify the association between CASP-8 ?652 6N ins/del polymorphism and cancer risk. According to the inclusion criteria, 19 case-control studies with a total of 23,172 cancer cases and 26,532 healthy controls were retrieved. Meta-analysis results showed that the del allele, del allele carrier and ins/del genotype of ?652 6N ins/del in the CASP-8 gene were negatively associated with cancer risk (OR=0.91, 95% CI=0.84–0.98, P=0.01; OR=0.88, 95% CI=0.80–0.96, P=0.005; OR=0.91, 95% CI=0.85–0.98, P<0.001; respectively, while no significant correlation was observed between the del/del genotype of ?652 6N ins/del and cancer risk (OR=0.89, 95% CI=0.79–1.01, P=0.08). In the subgroup analysis by ethnicity, the meta-analysis indicated that Caucasian populations harboring the del allele, del allele carriers and ins/del genotype had a lower cancer risk (OR=0.96, 95% CI=0.93–1.00, P=0.05; OR=0.86, 95% CI=0.75–1.00, P=0.05; OR=0.91, 95% CI=0.84–0.98, P=0.01; respectively). In addition, a negative association was found between the del allele of ?652 6N ins/del in the CASP-8 gene and cancer risk in the Asian population (OR=0.89, 95% CI=0.83–0.97, P=0.005). In conclusion, this meta-analysis suggests that the del allele, del allele carrier and ins/del geno-type of the ?652 6N ins/del polymorphism in the CASP-8 gene may be protective factors for cancer risk.




CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50,112 subjects.  


Disruptions of normal apoptotic pathways, which are mainly mediated by caspases, play an essential role in cancer development. Caspase-8 (CASP8) is encoded by the CASP8 gene and is centrally involved in the apoptosis of T lymphocytes. The association between a six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene and the risk of cancer is widely reported; however, study results have been inconsistent and contradictory. To evaluate the association between the CASP8 -652 6N del polymorphism and the risk of cancer and to overcome the limitations of any individual study, a meta-analysis based on a total of 23?700 cases and 26?412 controls from 30 case-control studies was conducted. The results of the overall analysis suggested that the CASP8 -652 6N del polymorphism is associated with decreased risk of cancer for the allele contrast [del versus ins: odd ratio (OR) = 0.86, 95% confidence interval (CI) = 0.80-0.92], the additive genetic model (del/del versus ins/ins: OR = 0.78, 95% CI = 0.69-0.88), the dominant genetic model (del/del+del/ins versus ins/ins: OR = 0.83, 95% CI = 0.78-0.89) and the recessive genetic model (del/del versus ins/ins+del/ins: OR = 0.84, 95% CI = 0.75-0.93). In addition, after stratification for ethnicity and cancer type, significantly reduced risk was found for Asians and Caucasians as well as for individuals in the colorectal cancer group and the 'other cancers' group. Accordingly, there is an association between the CASP8 -652 6N del polymorphism and reduced cancer risk, especially among Asians, Caucasians and those with colorectal cancer. However, further research, such as studies focusing on additional ethnic groups and cancer types, is needed to provide a more exact and comprehensive synthesis conclusion. PMID:22513478

Zhang, Fan; Yang, Yuan; Guo, Cheng; Wang, Yang



Effect of medicinal and aromatic plants on rumen fermentation, protozoa population and methanogenesis in vitro.  


The potential of tannins from 21 medicinal and aromatic plant leaves as antimethanogenic additives in ruminant feeds was investigated. The effect of tannin from these leaves on rumen fermentation parameters, protozoa population and methanogenesis was studied by incubating the samples [200?mg dry matter (DM)] without and with polyethylene glycol (PEG)-6000 (400?mg DM) as a tannin binder during 24-h incubation in the in vitro Hohenheim gas method. Based on the methane percentage estimated in the total gas produced, methane production in millilitre was calculated [methane volume (ml)?=?methane %?×?total gas produced (ml) in 24?h]. In the samples, crude protein and neutral detergent fibre (g/kg DM) ranged from 113 to 172 and from 352 to 444 respectively. The total phenol (TP; g/kg DM) content was highest in Terminalia chebula (274) followed by Hemigraphis colorata (71) and Sapindus laurifolia (51) respectively. In the remaining samples, it was <43?g/kg DM. Activity of tannins, as represented by the increase in gas volume on addition of PEG, ranged from 0 to 133%, with the highest being recorded in T. chebula. The per cent increase in methane on PEG addition was 0 for Ammi majus, Aristolochia indica, Cascabela thevetia, Ipomea nil and Lantana camara, illustrating that tannins present in these samples had no effect on methane concentration. The PEG addition increased the total protozoa count by >50% in A. indica and C. thevetica. One of the important findings of our study was that of the 21 samples screened, Entodinia population increased in 12 with PEG as compared to 7 where Holotricha increased, indicating higher susceptibility of Entodinia to tannin. There was no increase in the protozoa population with PEG when incubating Cardiospermum halicacabum, Clerodendrum inerme, Dioscorea floribunda, Nerium oleander and Selastras paniculatus, which strongly suggested that methane suppression recorded in these samples was not because of a defaunating effect of their tannins per se. The fermentation pattern reflected increased total volatile fatty acid (TVFA) concentration from 0 to 28.3% with PEG addition among the leaves. Our results confirmed further observations that methanogenesis in vitro is not essentially related to density of protozoa population. Secondly, medicinal and aromatic plants such as C. inerme, Gymnema sylvestre and Sapindus laurifolia containing tannins appear to have a potential to suppress in vitro methanogenesis. PMID:22385477

Bhatta, R; Baruah, L; Saravanan, M; Suresh, K P; Sampath, K T



Prevalence of the BRCA1 c.68_69delAG (BIC: 185delAG) mutation in women with breast cancer from north-central Poland and a review of the literature on other regions of the country  

PubMed Central

Aim of the study Germline mutations in BRCA tumor suppressor genes are strongly associated with breast and ovarian cancer. The lifetime risk of these cancers in women with BRCA1 mutation is 84% and 27%, respectively. Studies on the prevalence of BRCA1 c.68_69delAG congenital mutation, the most frequent in Ashkenazi Jews, among women with breast cancer from north-central Poland and review of the literature on other regions of the country. Evaluation of the c.68_69delAG association with breast cancer risk, with respect to women's age at diagnosis and family history of cancer. Material and methods 252 women with breast cancer, without any of the mutations c.5266dupC, c.181T > G, or c.4034delA, regardless of histological type and family history of cancer. The mutation was detected using allele-specific oligonucleotide polymerase chain reaction (ASO-PCR) assay and confirmed by sequence analysis. Results The c.68_69delAG mutation was disclosed in one out of the 252 women (0.4%), who had been diagnosed with breast cancer at age 43. Family investigations revealed the presence of c.68_69delAG also in the patient's mother, diagnosed with breast cancer at age 68. Sequence analysis confirmed the heterozygous status of the mutation, and family investigation its hereditary character. In the group of families with breast cancer history 1.4% frequency of c.68_69delAG was shown. Conclusions Among families with breast cancer aggregation, originating from north-central Poland, c.68_69delAG is a rare BRCA1 alteration, similarly to other central regions of the country, investigated by other authors. However, in northern, north-western and south-western parts of Poland, it occurs 2–4 times more frequently than in our region.

Janiszewska, Hanna; Bak, Aneta; Pilarska, Maria; Heise, Marta; Junkiert-Czarnecka, Anna; Laskowski, Ryszard; Haus, Olga



A systematic review and meta-analysis of 235delC mutation of GJB2 gene  

PubMed Central

Background The 235delC mutation of GJB2 gene is considered as a risk factor for the non-syndromic hearing loss (NSHL), and a significant difference in the frequency and distribution of the 235delC mutation has been described world widely. Methods A systematic review was performed by means of a meta-analysis to evaluate the influence of the 235delC mutation on the risk of NSHL. A literature search in electronic databases using keywords “235delC”, “GJB2” associated with “carrier frequency” was conducted to include all papers from January 1999 to June 2011. A total of 36 papers were included and there contained 13217 cases and 6521 controls derived from Oceania, American, Europe and Asian. Results A remarkable heterogeneity between these studies was observed. The combined results of meta-analysis showed that the 235delC mutant increased the risk of NSHL (OR?=?7.9, 95%CI 4.77?~?13.11, P <0.00001). Meanwhile, heterogeneity of genetic effect was also observed due to the ethnic specificity and regional disparity. Therefore, the stratified meta-analysis was subsequently conducted and the results indicated that the 235delC mutation was significantly correlated with the risk of NHSL in the East Asian and South-east Asian populations (OR?=?12.05, 95%CI 8.33~17.44, P <0.00001), but not significantly in the Oceania and European populations (OR?=?10.36, 95%CI: 4.68~22.96, Z?=?1.68, P >0.05). Conclusions The 235delC mutation of GJB2 gene increased the risk of NHSL in the East Asian and South-east Asian populations, but non-significantly associated with the NSHL susceptibility in Oceania and European populations, suggesting a significant ethnic specificity of this NSHL-associated mutation.



The E2FD/DEL2 factor is a component of a regulatory network controlling cell proliferation and development in Arabidopsis.  


An emerging view of plant cell cycle regulators, including the E2F transcription factors, implicates them in the integration of cell proliferation and development. Arabidopsis encodes six E2F proteins that can act as activators or repressors of E2F-responsive genes. E2FA, E2FB and E2FC interact with the retinoblastoma-like RBR protein and bind to DNA together with their DP partners. In contrast, E2FD, E2FE and E2FF (also known as DEL2, DEL1 and DEL3) are atypical E2Fs that possess duplicated DNA binding regions, lack trans-activating and RBR-binding domains and are believed to act as transcriptional inhibitors/repressors. E2FE/DEL1 has been shown to inhibit the endocycle and E2FF/DEL3 appears to control cell expansion but the role of E2FD/DEL2 has not been reported so far. In this study, we investigated the expression of E2FD/DEL2 and analysed the accumulation of its product. These studies revealed that E2FD/DEL2 accumulation is subject to negative post-translational regulation mediated by the plant hormone auxin. Moreover, the analysis of mutant and transgenic plants characterized by altered expression of E2FD/DEL2 has revealed that this atypical E2F can affect plant growth by promoting cell proliferation and repressing cell elongation. Overexpression of E2FD/DEL2 increased the expression of E2FA, E2FB and E2FE/DEL1 whereas its inactivation led to the up-regulation of genes encoding repressors of cell division. These results suggest that E2FD/DEL2 is part of a regulatory network that controls the balance between cell proliferation and development in Arabidopsis. PMID:19937368

Sozzani, Rosangela; Maggio, Caterina; Giordo, Roberta; Umana, Elisabetta; Ascencio-Ibañez, Jose Trinidad; Hanley-Bowdoin, Linda; Bergounioux, Catherine; Cella, Rino; Albani, Diego



Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon  

SciTech Connect

The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

Coughlin, R.M.; Bement, W.O.; Maloney, W.V. (Pecten International Company, Houston, TX (United States))



Paleomagnetic evidence for an episodic eruptive history of the Cerros del Rio volcanic field, New Mexico  

NASA Astrophysics Data System (ADS)

The Pliocene to Quaternary (~2.6-1.14 Ma) Cerros del Rio volcanic field of northern New Mexico forms a dissected basaltic plateau sourced by multiple eruptive centers. Paleomagnetic data compliment geologic mapping, geochronologic and geochemical data to define the spatial and temporal eruptive history of Cerros del Rio volcanic deposits. The preserved stratigraphic sequence reflects three principal phases of volcanism; 1) 2.7-2.6 Ma, 2) 2.5-2.2 Ma, and 3) 1.5-1.1 Ma. Paleomagnetic data collected from 85 sites that span the area of the volcanic field largely sample phase-1 deposits that record the Guass normal-polarity chron or phase-2 deposits that record the Matuyama reversed-polarity chron. A grand mean of individual sites (excluding transitional directions) is D = 352.8°, I = 49.7°, k= 14, a95 = 3.9. However, normal- and reversed-polarity group means are not statistically antipodal, with the normal-polarity inclination being significantly shallower than an expected (55°) dipole inclination. This failed reversal test suggests that paleosecular variation has not be fully averaged within both polarity groups, despite a basis on abundant data from multiple eruptive centers. Compared to variation recorded by the full volcanic field, site directions from individual eruptive centers have restricted dispersion, indicating that the centers formed quickly relative to paleosecular variation. Grouping data within individual eruptive centers to calculate eruptive-group means (EGM), directions of the normal- and reversed-polarity EGM remain skewed from antipodal. Modal analysis demonstrates the presence of multiple directional clusters among the normal-polarity EGM whereas the frequency distribution of reversed polarity EGM are symmetrical about their maximum. These paleomagnetic directional characteristics indicate that voluminous phase-1 deposits of the Cerros del Rio volcanic field probably erupted episodically during short time intervals and that several individual volcanic centers were erupted nearly synchronously.

Hudson, M. R.; Thompson, R. A.



L-Band Measurement of Nova Del 2013 Consistent with Presence of Dust  

NASA Astrophysics Data System (ADS)

An L-band measurement of Nova Del 2013 on 29.17 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded a magnitude of L = +2.6 +/- 0.3. Vega (alpha Lyrae) was used as the standard star. This flux level is consistent with a small amount of dust having formed recently as reported in ATEL 5431.

Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.



Use of del Nido cardioplegia solution and a low-prime recirculating cardioplegia circuit in pediatrics.  


The evolution of myocardial protection techniques has been both the source of milestone advancements and controversial debate in cardiac surgery. Our institution has modified a low-prime cardioplegia system (CPS) and adopted a single-dose cardioplegia solution (del Nido cardioplegia) for our congenital heart disease population. The goal of this article is to describe our CPS and outline our myocardial protection protocol. These techniques have allowed us to minimize circuit surface area, operate uninterrupted, and safely protect the myocardium during extended ischemic periods. PMID:23691784

Ginther, Richard M; Gorney, Ronald; Forbess, Joseph M



Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies  

NASA Astrophysics Data System (ADS)

Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as well as the regional precipitation regime. The very high frequency measurements from XRF scan allows us to obtain decadal scale resolution from the lamination. Pollen analysis identifies local shifts in the forest-steppe ecotone over time. Results from this core represent an important contribution to our knowledge of Southern South American Holocene paleoclimate. Its ideal location in a climatically sensitive and hydrologically protected site, its stratigraphic integrity, and the high temporal resolution of the isotopic record as a consequence of the short residence time of water in the lake, and its proximity to a dense network of paleoclimate records from the region provide a unique paleoclimate reconstruction for this region.

Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.



Early neogene history of the central American arc from Bocas del Toro, western Panama  

USGS Publications Warehouse

A newly discovered sequence of lower to middle Miocene rocks from the eastern Bocas del Toro archipelago, western Panama, reveals the timing and environment of the earliest stages in the rise of the Isthmus of Panama in this region. Two new formations, the Punta Alegre Formation (lower Miocene, Aquitanian to Burdigalian) and the Valiente Formation (middle Miocene, Langhian to Serravallian), are here named and formally described. The Punta Alegre Formation contains a diagnostic microfauna of benthic and planktic foraminifera and calcareous nannofossils that indicate deposition in a 2000-m-deep pre-isthmian neotropical ocean from as old as 21.5-18.3 Ma. Its lithology varies from silty mudstone to muddy foraminiferal ooze with rare thin microturbidite layers near the top. The Valiente Formation, which ranges in age from 16.4 to ca. 12.0 Ma, lies with slight angular unconformity on the Punta Alegre Formation and consists of five lithofacies: (1) columnar basalt and flow breccia, (2) pyroclastic deposits, (3) coarse-grained volcaniclastic deposits, (4) coral-reef limestone with diverse large coral colonies, and (5) marine debris-flow deposits and microturbidities. These lithofacies are interpreted to indicate that after ca. 16 Ma a volcanic arc developed in the region of Bocas del Toro and that by ca. 12 Ma an extensively emergent archipelago of volcanic islands had formed. 39Ar/40Ar dating of basalt flows associated with the fossiliferous sedimentary rocks in the upper part of the Valiente Formation strongly confirms the ages derived from planktic foraminifera and nannofossils. Paleobathymetric analysis of the two new formations in the Valiente Peninsula and Popa Island, in the Bocas del Toro archipelago, shows a general shallowing from lower- through upper-bathyal to upper-neritic and emergent laharic and fluviatile deposits from ca. 19 to 12 Ma. The overlying nonconformable Bocas del Toro Group contains a lower transgressive sequence ranging from basal nearshore sandstone to upper-bathyal mudstone (ca. 8.1-5.3. Ma) and an upper regressive sequence (5.3-3.5 Ma). A similar paleobathymetric pattern is observed from the Gatun to Chagres Formations (12-6 Ma) in the Panama Canal Basin area and in the Uscari, Rio Banana, Quebrada Chocolate, and Moin Formations (8-1.7 Ma) in the southern Limo??n Basin of Costa Rica.

Coates, A. G.; Aubry, M. -P.; Berggren, W. A.; Collins, L. S.; Kunk, M.



Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California  

SciTech Connect

Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

Bischoff, J.L.; Rosenbauer, R.J.



Canalization analysis of birth weight in Bruna dels Pirineus beef cattle.  


Although heteroskedasticity has been a main topic of interest in beef cattle during recent decades, the current availability of canalization models provided new insights for animal breeding programs. Within this context, birth BW (BWT) was analyzed in the Bruna dels Pirineus beef cattle breed by implementing canalization models that accounted for heterogeneous residual variances due to systematic, permanent environmental effects and additive genetic effects. Analyses were performed on BWT data from 8,130 calves born in 12 commercial breeding herds contributing to the yield recording scheme of the Bruna dels Pirineus breed. Analytical models accounted for direct additive genetic, permanent environmental, and 4 systematic effects (i.e., age of the dam, sex of the calf, birth type, and herd-year-season), and the same effects were evaluated as potential sources of variation in the residual term. Their relevance was checked by the deviance information criterion (DIC), and only residual additive genetic, permanent environmental, birth type, and herd-year-season remained in the operational model, all of them originating relevant reductions in the DIC parameter. Bruna dels Pirineus calves showed a moderate heritability of 0.30 (95% high posterior density, 0.19 to 0.40) for BWT; additional additive genetic variability was revealed in the residual term, this being positively correlated with the direct additive genetic component (0.44; 95% high posterior density, 0.37 to 0.54). Genetic trends were evaluated on both sources of additive genetic variance, and relevant patterns were identified in several herds. Although this breed did not evidence a homogeneous genetic trend for the whole population, herd-specific positive and negative trends were revealed, suggesting the plausibility of genetic selection for canalization on BWT in beef cattle breeds. These results must be viewed as a contribution to the canalization research field, providing relevant information for the breeding scheme of the Bruna dels Pirineus breed, as well as important insights about the genetic background of BWT for the beef industry worldwide. PMID:23658344

Fina, M; Ibáñez-Escriche, N; Piedrafita, J; Casellas, J



Anomalous ocean load tide signal observed in lake-level variations in Tierra del Fuego  

NASA Astrophysics Data System (ADS)

We demonstrate the application of a 100 km long lake as a sensor for studying the tidal effects on Tierra del Fuego main island. The lake-level variations observed in Lago Fagnano reflect both the direct response to the tidal potential and the indirect effect of the ocean tidal loading. Modeling both contributions explains the observed tidal signal in the lake to about 70%. Underestimated model load tide amplitudes are found to be probably responsible for the remaining difference. We interpret this discrepancy as a hint for regional elastic lithosphere properties differing substantially from those represented by currently available global models.

Richter, A.; Hormaechea, J. L.; Dietrich, R.; Perdomo, R.; Fritsche, M.; Del Cogliano, D.; Liebsch, G.; Mendoza, L.



Further X-ray observations of Nova Del 2013 with Swift  

NASA Astrophysics Data System (ADS)

We observed Nova Del 2013 (see CBET #3628) with the Swift satellite on 2013-08-18, four days after discovery (see also ATEL #5283). The exposures were carried out between 0.0 and 15.7 UT, and are therefore coincident with the first appearance of gamma-ray emission from this nova as seen with the Fermi-LAT (ATEL #5302). The XRT instrument was operated in Window Timing (WT) in order to mitigate the impact of optical loading on the CCD, and the total exposure time was 4522s.

Nelson, T.; Mukai, K.; Chomiuk, L.; Sokoloski, J.; Weston, J.; Zheng, Y.; Rupen, M.; Mioduszewski, A.; Linford, J.; Finzell, T.



Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.  


A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives. PMID:17732038

Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W



A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairment  

PubMed Central

Fifty to eighty percent of autosomal recessive congenital severe to profound hearing impairment result from mutations in a single gene, GJB2, that encodes the protein connexin 26. One mutation of this gene, the 35delG allele, is particularly common in white populations. We report evidence that the high frequency of this allelic variant is the result of a founder effect rather than a mutational hot spot in GJB2, which was the prevailing hypothesis. Patients homozygous for the 35delG mutation and normal hearing controls originating from Belgium, the UK, and the USA were genotyped for different single nucleotide polymorphisms (SNPs). Four SNPs mapped in the immediate vicinity of GJB2, while two were positioned up to 76 kb from it. Significant differences between the genotypes of patients and controls for the five SNPs closest to GJB2 were found, with nearly complete association of one SNP allele with the 35delG mutation. For the most remote SNP, we could not detect any association. We conclude that the 35delG mutation is derived from a common, albeit ancient founder.???Keywords: connexin 26; GJB2; 35delG; founder effect

Van Laer, L; Coucke, P; Mueller, R; Caethoven, G; Flothmann, K; Prasad, S; Chamberlin, G; Houseman, M; Taylor, G; Van de Heyning, C M; Fransen, E; Rowland, J; Cucci, R; Smith, R; Van Camp, G



Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction.  


Inflammation in the course of systemic inflammatory response syndrome (SIRS) or sepsis often results in dysregulation of the hypothalamic-pituitary-adrenal axis; however, the underlying mechanisms are not well understood. The adrenal gland is highly vascularized; thus, we hypothesized that endothelial dysfunction may actively participate in inflammation-related adrenal insufficiency. To address this hypothesis, we used the properties of developmental endothelial locus-1 (Del-1), which is an endothelial-derived anti-inflammatory factor that antagonizes integrin-dependent leukocyte adhesion. Here we identified that Del-1 is expressed in the adrenal gland and that its expression was down-regulated upon SIRS induction by systemic lipopolysaccharide administration. Furthermore, we observed increased leukocyte accumulation, inflammation, and higher apoptosis in the adrenal glands of Del-1-deficient mice as compared with wild-type mice. Strikingly, Del-1 deficiency was also associated with reduced corticosterone and ACTH levels 24 hours after lipopolysaccharide administration. Together, these data suggest that Del-1 may act as a gatekeeper of adrenal gland inflammation and may regulate the integrity of the hypothalamic-pituitary-adrenal axis stress response, thereby modulating adrenal (dys)function in the course of SIRS. PMID:23364949

Kanczkowski, Waldemar; Chatzigeorgiou, Antonios; Grossklaus, Sylvia; Sprott, David; Bornstein, Stefan R; Chavakis, Triantafyllos



Atmospheric background trace elements deposition in Tierra del Fuego region (Patagonia, Argentina), using transplanted Usnea barbata lichens.  


Lichen, Usnea barbata, transplants taken from Tierra del Fuego (south Patagonia, Argentina) were tested as potential biomonitors of atmospheric airborne deposition in an apparently pristine environment. In 2005, lichens were sampled in a reference site (n?=?31) and transplanted in the northern Region of Tierra del Fuego. After, respectively, 1 month and 1 year of exposure, we collected them. The aim of the study was to determine the bioaccumulation of 26 elements in order to evaluate the background levels in the selected area. Samples were analyzed by the sector field inductively coupled plasma mass spectrometry. Discriminant analysis on principal component analysis factors was applied in order to explore the relationship among the different elements as far as time and spatial variation in transplants regards. The analysis was tested by Monte Carlo test based on 999 replicates. The most important contamination source resulted to be the atmospheric soil particle deposition. Furthermore, the results were compared with those obtained from the lichens collected in central and southern Tierra del Fuego. This study confirms the ability of U. barbata to reflect the background levels of the 26 elements in that environment. Compared with other background sites in the world, we did confirm that Tierra del Fuego lichens have a low content of the studied elements. Tierra del Fuego turned out not to be a pristine environment as supposed, but it can be considered as a reference basal ecosystem for useful comparisons among different geographical areas. These findings can be very relevant and useful for environmental conservation programs. PMID:21409357

Conti, Marcelo Enrique; Finoia, Maria Grazia; Bocca, Beatrice; Mele, Giustino; Alimonti, Alessandro; Pino, Anna



Aplicación del \\  

Microsoft Academic Search

SUMMARY The MINI (International Mini Neuropsychiatric Interview) is a brief and high structured interview of the main psychiatric disorders of the IDC - 10 and DSM-IV in order to be employed by psychiatrists and physi- cians not psychiatrists afterwards short time training. It was elaborated by Y. Lecrubier from the \\



Laterality Preference and Cognition: Cross-Syndrome Comparison of Patients with Trisomy 21 (Down), del7q11.23 (Williams–Beuren) and del22q11.2 (DiGeorge or Velo-Cardio-Facial) Syndromes  

Microsoft Academic Search

We report on a cross-syndrome comparison of hand, foot, eye and ear laterality in three groups of individuals with different\\u000a genetic disorders (trisomy 21, del7q11.23, and del22q11.2) to test the relationship between atypical laterality and intellectual\\u000a disability. These groups were compared to a group of typically developing persons. Hand, foot, eye and ear laterality was\\u000a assessed using item tasks, conducted

Michèle Carlier; Aude Gérard Desplanches; Nicole Philip; Silvia Stefanini; Stefano Vicari; Virginia Volterra; Christine Deruelle; Gene Fisch; Anne Lise Doyen; Anne Swillen



Expression of a cyanobacterial {del}{sup 6}-desaturase gene results in {gamma}-linolenic acid production in transgenic plants  

SciTech Connect

Gamma-linolenic acid (GLA), a nutritionally important fatty acid in human and animal diets, is not produced in oil seed crops. Many oil seed plants, however, produce significant quantities of linoleic acid, a fatty acid that could be converted to GLA by the enzyme {del}{sup 6}-desaturase if it were present. As a first step to producing GLA in oil seed crops, we have cloned a cyanobacterial {del}{sup 6}-desaturase gene. Expression of this gene in transgenic tobacco resulted in GLA accumulation. Octadecatetraenoic acid, a highly unsaturated, industrially important fatty acid, was also found in transgenic tobacco plants expressing the cyanobacterial {del}{sup 6}-desaturase. This is the first example of engineering the production of `novel` polyunsaturated fatty acids in transgenic plants. 28 refs., 4 figs., 1 tab.

Reddy, A.S.; Thomas, T.L. [Texas A & M Univ., College Station, TX (United States)



Superfund Record of Decision (EPA Region 9): Del Amo Facility Waste Pits Operable Unit, Los Angeles, CA, September 5, 1997  

SciTech Connect

This decision document presents the selected remedial action for the Del Amo Waste Pits Operable Unit (Waste Pits OU) of the Proposed Del Amo Superfund Site (Del Amo Site), in Los Angeles, California. The remedy selected in this ROD addresses the principal threat remaining at the Waste Pits Area by selecting actions that will prevent future releases of hazardous substances from the remaining waste materials present in the waste pits, either upward to the surface, downward into the groundwater, or laterally out from the pits, that would create unacceptable risks to public health or welfare or the environment. The ROD also selects measures intended to prevent additional contamination of groundwater beneath the Waste Pits Area by selecting response actions to clean-up hazardous substance contamination that had been previously releases from the waste pits and is currently present in the vadose zone soils.




[Tierra del Fuego: the scientific-political construction of exclusion and counter-image of the ideal city dweller].  


Due to its late incorporation into the national State, the social, economic and political setting of the Argentine province Tierra del Fuego differed from that of the rest of the national territory. In the construction of dependent otherness, objectifications and representations were imposed by state-related and non-state-related institutions, among other agencies. In this context, the Salesian mission of La Candelaria and Ushuaia's Jail for recidivists stand out as spaces in which biopolitics was concretised. The native population and criminals in Tierra del Fuego were those to be subjugated. The thesis of the extinction of the Indian and the simultaneous exaltation of the criminal as the subject of progress identified the scientific and political mechanisms by which the exclusion of certain social groups (Tierra del Fuego's indigenous population) and the inclusion of others (criminals) were regulated. PMID:22849216

Nacach, Gabriela




PubMed Central

El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.

Garofoli, Adrian; Montoya, Paola; Elias, Carlos; Benzo, Roberto



Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua  

NASA Astrophysics Data System (ADS)

The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation of the local population, as: -General education on disaster prevention, participative events; -Investigation of awareness level and information needs for different population groups; -Specific educational measures in the schools; -Publication of brochures, calendars, news paper articles, radio programs, TV spots -Development of local tsunami hazard maps, 1:5,000 scale; (based on previous regional tsunami hazard mapping projects and local participation) -Development of a tsunami warning plan; -Improvements of the national tsunami warning system. -Installation of sirens for tsunami warning -Installation of tsunami signs, indicating hazardous areas, evacuation routes, safe places; -Realization of evacuation drills in schools. Based on the experiences gained in Masachapa it is planned to run similar projects in other areas along the Nicaraguan Pacific coast. In the project participated the local municipality and local stakeholders of San Rafael del Sur, Ministry of Education, National Police, Nicaraguan Red Cross, Ministry of Health, Ministry of Tourism, Nicaraguan Geosciences Institute (INETER), National System for Disaster Prevention (SINAPRED), Swiss Agency for Development and Cooperation (SDC). It was financed by SDC and INETER.

Strauch, W.; Talavera, E.; Acosta, N.; Sanchez, M.; Mejia, E.



La estructura dinámica del cinturón de Kuiper interior y la formación de Urano y Neptuno  

NASA Astrophysics Data System (ADS)

De acuerdo a los más recientes estudios sobre la formación de Urano y Neptuno, éstos podrían haber sufrido una importante migración radial hacia el exterior, debido al intercambio de momento angular con los planetesimales presentes en esa región durante las últimas etapas de la formación del Sistema Solar. Esta migración radial habría tenido importantes consecuencias sobre la presente estructura dinámica del cinturón cometario de Kuiper. Tal como lo reflejan las observaciones, la mayoría de los cuerpos observados en el cinturón de Kuiper se encuentran en resonancia de movimientos medios exteriores con Neptuno, hecho que también se refleja en la presente órbita de Plutón. En el presente trabajo se estudia tanto numérica como analíticamente la influencia de la variación de las masas de Urano y Neptuno durante el proceso de migración sobre las probabilidades de captura en algunas de las resonancias exteriores de Neptuno. Se estudia también la influencia de encuentros gravitacionales mutuos sobre la estabilidad de las órbitas resonantes. Este estudio ofrece argumentos de plausibilidad para explicar por qué ninguno de los objetos descubiertos en el cinturón de Kuiper se encontraría en la resonancia 2:1.

Melita, M. D.; Brunini, A.


A del(X)(p11) carrying SRY sequences in an infant with ambiguous genitalia  

PubMed Central

Background SRY (sex-determining region, Y) is the gene responsible of gonadal differentiation in the male and it is essential for the regular development of male genitalia. Translocations involving the human sex chromosomes are rarely reported, however here we are reporting a very rare translocation of SRY gene to the q -arm of a deleted X chromosome. This finding was confirmed by cytogenetic, fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR). Case presentation A 7-month infant was clinically diagnosed as an intersex case, with a phallus, labia majora and minora, a blind vagina and a male urethra. Neither uterus nor testes was detected by Ultrasonography. G-banding of his chromosomes showed 46,X,del(X)(p11) and fluorescent in situ hybridization (FISH) analysis showed a very small piece from the Y chromosome translocated to the q-arm of the del(X). Polymerase chain reaction (PCR) analysis revealed the presence of material from the sex-determining region Y (SRY) gene. Conclusion It is suggested that the phenotype of the patient was caused by activation of the deleted X chromosome with SRY translocation, which is responsible for gonadal differentiation.

Ellaithi, M; Gisselsson, D; Nilsson, T; Abd El-Fatah, S; Ali, T; Elagib, A; Ibrahim, ME; Fadl-Elmula, I



Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations.  


Lenalidomide is an effective drug in low-risk myelodysplastic syndromes (MDS) with isolated del(5q), although not all patients respond. Studies have suggested a role for TP53 mutations and karyotype complexity in disease progression and outcome. In order to assess the impact of complex karyotypes on treatment response and disease progression in 52 lenalidomide-treated patients with del(5q) MDS, conventional G-banding cytogenetics (CC), single nucleotide polymorphism array (SNP-A), and genomic sequencing methods were used. SNP-A analysis (with control sample, lymphocytes CD3+, in 30 cases) revealed 5q losses in all cases. Other recurrent abnormalities were infrequent and were not associated with lenalidomide responsiveness. Low karyotype complexity (by CC) and a high baseline platelet count (>280 × 10(9) /l) were associated with the achievement of haematological response (P = 0·020, P = 0·013 respectively). Unmutated TP53 status showed a tendency for haematological response (P = 0·061). Complete cytogenetic response was not observed in any of the mutated TP53 cases. By multivariate analysis, the most important predictor for lenalidomide treatment failure was a platelet count <280 × 10(9) /l (Odds Ratio = 6·17, P = 0·040). This study reveals the importance of a low baseline platelet count, karyotypic complexity and TP53 mutational status for response to lenalidomide treatment. It supports the molecular study of TP53 in MDS patients treated with lenalidomide. PMID:23614682

Mallo, Mar; Del Rey, Mónica; Ibáñez, Mariam; Calasanz, M José; Arenillas, Leonor; Larráyoz, M José; Pedro, Carmen; Jerez, Andrés; Maciejewski, Jaroslaw; Costa, Dolors; Nomdedeu, Meritxell; Diez-Campelo, María; Lumbreras, Eva; González-Martínez, Teresa; Marugán, Isabel; Such, Esperanza; Cervera, José; Cigudosa, Juan C; Alvarez, Sara; Florensa, Lourdes; Hernández, Jesús M; Solé, Francesc



Epidemiological surveillance of cystic echinococcosis in rural population of Tierra del Fuego, Argentina, 1997-2006.  


Cystic echinococcosis (CE) is the most prevalent zoonosis in Tierra del Fuego. In 1997, ulrasonography (US) was selected as the method of choice for the development of population surveys for epidemiological surveillance and early diagnosis in rural population. The aim of this work was to present the results of the epidemiological surveillance of CE by means of US in rural population of Tierra del Fuego, Argentina between 1997 and 2006. The ultrasonographic diagnostic was realized once a year. The population was stratified in children (4 to 17 years) and adults. From each individual, name, age, sex, actual residence and origin were registered. The images compatible with cysts were graded according to location, number and characteristics. A total of 1400 rural inhabitants were examined for CE. From the total of studied individuals, 27 (1.9%) exhibited images compatible with cysts on the abdominal ultrasound scan. Thirteen of these persons were finally diagnosed as having CE. The overall prevalence of CE was 0.9%. This value is in accordance with the decrease in the prevalence observed in the definitive host and the intermediate hosts (sheep and cattle). The absence of cases in children during the studied period, evidence no transmission of the disease to humans in the recent past. PMID:18996221

Zanini, Fabián; Suárez, Carlos; Pérez, Héctor; Elissondo, María C



L10P and P158DEL DJ-1 Mutations Cause Protein Instability, Aggregation, and Dimerization Impairments  

PubMed Central

A variety of mutations in the gene encoding DJ-1 protein are causal of autosomal recessive early-onset parkinsonism. Recently, a novel pathogenic homozygous DJ-1 missense mutation resulting in the L10P amino acid substitution was reported. In a separate study, a novel homozygous mutation resulting in the deletion of DJ-1 residue P158 was also reported to be causative of disease. The specific effects of the novel L10P and P158DEL mutations on protein function have not been studied. Herein, L10P and P158DEL DJ-1 proteins were assessed for protein stability, dimerization, solubility, subcellular localization, and protective function in comparison to WT and the L166P DJ-1 pathogenic variant. It was discovered that in comparison to WT protein, L10P, L166P, and P158DEL DJ-1 variants exhibited dramatically reduced protein stabilities. Degradation of each of the respective pathogenic mutants appeared to be mediated in-part by the proteasome. Interestingly, unlike L166P DJ-1, the L10P and P158DEL DJ-1 variants retained the ability to dimerize with WT DJ-1 protein; however, neither of these mutants was able to form homodimers. Additionally, the L10P, L166P, and P158DEL DJ-1 variants exhibited altered profiles on size-exclusion chromatography and demonstrated reduced solubilities in comparison to WT protein, and the latter aberration could be exacerbated in the presence of MG-132. Further, cells stably expressing L10P DJ-1 were more vulnerable to treatments with proteasome inhibitors, suggesting that L10P DJ-1 may be toxic to cells under conditions of proteasome stress. Taken together, these findings suggest that diverse aberrant mechanisms, including alterations in protein stability and protein folding, are associated with the pathogenicity of the L10P and P158DEL DJ-1 variants.

Ramsey, Chenere P.; Giasson, Benoit I.



CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis.  


It is possible that reduced function of DNA repair and cell-cycle control genes increases the individual susceptibility to malignant melanoma. As CHEK2 is a cell-cycle master controller, we tested the hypothesis that heterozygosity for the frameshift alteration CHEK2*1100delC is associated with increased risk of malignant melanoma. First, we performed case-control studies of 1,152 Danish and 752 German individuals with malignant melanoma compared with 9,142 Danish and 3,718 German controls. Second, we performed a meta-analysis of CHEK2*1100delC and malignant me