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1

Oleander (Nerium oleander) (image)  

MedlinePLUS

Oleander (Nerium oleander) is a common ornamental evergreen shrub. It is used as a freeway median divider in warmer states, such ... leaf may kill an adult. This photograph shows oleander not yet in bloom.

2

Cytotoxicity and Antimicrobial Activity of Nerium oleander Extracts  

Microsoft Academic Search

El Sawi, N.M., Geweely, N.S., Qusti, S., Mohamed, M. and Kamel, A. 2010. Cytotoxicity and antimicrobial activity of Nerium oleander extracts. J. Appl. Anim. Res., 37: 25–31.The antimicrobial properties of the crude and pure extracts of Nerium oleander were investigated against three Gramve bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteritidis), three Gram +ve bacteria (Bacillus subtilis, Listeria monocytogenes and

Nagwa M. El Sawi; Neveen S. Geweely; Safaa Qusti; M. Mohamed; A. Kamel

2010-01-01

3

[Chemical burns caused by the shrub nerium oleander].  

PubMed

Nerium Oleander is a shrub that grows naturally in the Mediterranean regions. In Morocco it is found in wet places. It is famous for its risk of systemic toxicity in cases of poisoning because of the presence of two alkaloids, especially oleandrine. The literature describes cases of local use of leaves of this plant against scabies, haemorrhoids, and boils. We report two cases of chemical burns of different gravity due to Nerium Oleander. This should lead to more widely diffused information for the general population and strict regulation of its marketing. PMID:21991211

Bakkali, H; Ababou, M; Nassim Sabah, T; Moussaoui, A; Ennouhi, A; Fouadi, F Z; Siah, S; Ihrai, H

2010-09-30

4

Two new triterpenoid isomers from Nerium oleander leaves  

Microsoft Academic Search

Two new triterpenoid isomers ?-neriursate (1) and ?-neriursate (2) have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3?-acetophenoxy-urs-12-en-28-oic acid and 3?-acetophenoxy-urs-12-en-28-oic acid, respectively. The structure elucidation is based on spectroscopic methods, including 1D (H NMR, C NMR) and 2D (H-H COSY, NOESY, HMQC, HMBC and J-resolved) NMR data and chemical transformation.

Bina S. Siddiqui; Nasima Khatoon; Sabira Begum; Saima A. Durrani

2009-01-01

5

Experimental oleander (Nerium oleander) intoxication in broiler chickens (Gallus gallus).  

PubMed

Dried leaves of oleander were orally given at a single dose of 500 mg/kg body weight to 20 clinically healthy male chickens. Clinical signs of toxicosis began to appear about 1 h after receiving the oleander and included hypersalivation, vomiting, diarrhea, deep depression, and sudden death. Also, hyperemia in the combs and wattles was obviously seen. Electrocardiograms (ECG) were repeatedly recorded at 30 min intervals. ECGs findings included increasing the QRS duration in some birds and various kinds of arrhythmias. Bradycardia was the most frequently detected finding (30.43%). During necropsy, there were congestion and hemorrhages in the visceral organs particularly in heart, liver, kidney, and lung. Histopathology revealed myocardial cell necrosis with hyperemia and hemorrhage, severe diffuse pulmonary congestion and edema, severe renal congestion and hemorrhage with tubular necrosis, and coagulative necrosis of hepatocytes with hyperemia and hemorrhage. There were also congestion, mild epithelial necrosis and desquamation with infiltration of mononuclear inflammatory cells in the proventriculus of all birds. There was also mild to moderate congestion in the intestines with scattered necrosis of surface enterocytes. The lack of information about the toxicity of oleanders in poultry was the main cause for this study. The results suggest that chickens appear to respond to oleander poisoning in a manner similar to other species. PMID:21576188

Omidi, Arash; Razavizadeh, Alireza T; Movassaghi, Ahmad R; Aslani, Mohammad R

2012-08-01

6

Clinical and pathological aspects of experimental oleander (Nerium oleander) toxicosis in sheep.  

PubMed

Dried Nerium oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to six native male sheep. Clinical signs of toxicosis in sheep began to appear about 30 min after receiving the oleander and included decrease of the heart rate followed by cardiac pauses and tachyarrhythmias; ruminal atony, mild to moderate tympany, abdominal pain, polyuria and polakiuria. Electrocardiography revealed bradycardia, atrio-ventricular blocks, depression of S-T segments, ventricular premature beats and tachycardia, and ventricular fibrillation. Five sheep died within 4-12 h and one survived. At necropsy there were varying degrees of haemorrhages in different organs and gastroenteritis. Histopathological examination of tissue sections revealed myocardial degeneration and necrosis, degeneration and focal necrosis of hepatocytes, necrosis of tubular epithelium in kidneys, oedema in the lungs, and ischemic changes in the cerebrum. PMID:15563108

Aslani, M R; Movassaghi, A R; Mohri, M; Abbasian, A; Zarehpour, M

2004-10-01

7

[A non-fatal Nerium oleander self-poisoning: case report and discussion].  

PubMed

Nerium oleander is potentially lethal plants after ingestion. We report a case of poisoning by these plants. Our patient complained of nausea, vomiting, and diarrhoea. He had bradycardia during first twelve hours. He was discharge after 3 days. All parts of these plants are toxic and contain a variety of cardiac glycosides including oleandrin. In most cases, clinical management of poisoning by N. oleander involves administration of activated charcoal and supportive care. Digoxin specific Fab fragments are an effective treatment. PMID:21890104

Hugues, T; Arnoult, M; Beau, N; Yaici, K; Mélandri, P; Saoudi, N; Gibelin, P

2012-04-01

8

Three new cardenolides from methanol extract of stems and twigs of Nerium oleander.  

PubMed

Two new cardenolide monoglycosides, cardenolides B-1 (1) and B-2 (2) were isolated from Nerium oleander, together with oleagenin (3) which is the first isolated compound from natural sources. The structure of compounds 1-3 were established on the basis of their spectroscopic data. PMID:20686265

Bai, Liming; Zhao, Ming; Toki, Asami; Sakai, Jun-ichi; Yang, Xiao-yang; Bai, Yuhua; Ando, Mariko; Hirose, Katsutoshi; Ando, Masayoshi

2010-08-01

9

Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats.  

PubMed

Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities. Herein, the hypolipidemic potential of the ethanolic extract of flowers of Nerium oleander (ENO) in a minimal dose was assessed. A high fat diet (HFD) resulted in a significant increase in cardiac lipids and lipoproteins and an increase in body weight gain. Simultaneous treatment with ENO significantly lowered the increase in body weight gain, lipid and lipoprotein levels, with a concomitant increase in HDL in the plasma and heart when compared to HFD-fed rats. Likewise, the activities of lipolytic enzymes were also upheld by the ENO treatment in the heart compared to HFD-fed rats. The above findings highlight the possible mechanism of N. oleander as a hypolipidemic agent in its use in folklore medicine as a cardiotonic. PMID:21726133

Gayathri, Veeraraghavan; Ananthi, Subhash; Chandronitha, Chandranayagam; Sangeetha, Marimuthu Kannan; Vasanthi, Hannah R

2011-07-01

10

A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning.  

PubMed

Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) are potentially lethal plants after ingestion. Poisoning by these plants is a common toxicological emergency in tropical and subtropical parts of the world and intentional self-harm using T. peruviana is prevalent in South Asian countries, especially India and Sri Lanka. All parts of these plants are toxic, and contain a variety of cardiac glycosides including neriifolin, thevetin A, thevetin B, and oleandrin. Ingestion of either oleander results in nausea, vomiting, abdominal pain, diarrhoea, dysrhythmias, and hyperkalemia. In most cases, clinical management of poisoning by either N. oleander or T. peruviana involves administration of activated charcoal and supportive care. Digoxin specific Fab fragments are an effective treatment of acute intoxication by either species. However, where limited economic resources restrict the use of such Fab fragments, treatment of severely poisoned patients is difficult. Data from case reports and clinical studies were reviewed to identify treatments supported by evidence for the management of poisoning by N. oleander and T. peruviana. PMID:20438743

Bandara, Veronika; Weinstein, Scott A; White, Julian; Eddleston, Michael

2010-09-01

11

Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity.  

PubMed

We evaluated the effectiveness of Anvirzel™, an aqueous extract of Nerium oleander on HIV infection of human peripheral blood mononuclear cells. Oleandrin, the principle cardiac glycoside (CG) in Anvirzel™ has been shown to exhibit anti-cancer properties but its efficacy against HIV is unknown. Treatment with Anvirzel™ significantly reduced the infectivity of virus produced from infected cells without any change in the total amount of virus produced. This is in contrast to treatment with AZT, a potent inhibitor of HIV replication that has been shown to significantly reduce virus production. Relative to untreated cultures, virus in cultures treated with oleandrin had significantly reduced expression of the envelope protein gp120, the sole determinant of virus infectivity, suggesting a novel mechanism underlying the impaired infectivity. These results support the potential utility of the Nerium oleander aqueous extract, containing the CG oleandrin as a novel candidate anti-HIV therapeutic. PMID:23127567

Singh, Shailbala; Shenoy, Sachin; Nehete, Pramod N; Yang, Peiying; Nehete, Bharti; Fontenot, Danielle; Yang, Guojun; Newman, Robert A; Sastry, K Jagannadha

2013-01-01

12

Antioxidant Activity and Total Phenolic Content of Nerium oleander L. Grown in North of Iran.  

PubMed

IN THIS STUDY, WE HAVE EXAMINED THE ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENT OF DIFFERENT EXTRACTS (INCLUDING WATER, METHANOL, WATER : methanol and acetone) of Nerium oleander L. grown in the north of Iran by employing various in-vitro assay, i.e. DPPH free radical scavenging, reducing power and total antioxidant capacity through the Mo (VI) reduction. The extracts showed different levels of efficacy in each assay in a dose-dependent manner. Methanolic and aqueous methanolic extracts with the highest amount of total phenolic (by using the Folin-Ciocalteu phenol reagent method), were the most potent antioxidant in all of the assays that were used. According to the results of present study, Nerium oleander L. flowers were found to serve as a potential source of natural antioxidants. PMID:24250545

Mohadjerani, Maryam

2012-01-01

13

Antioxidant Activity and Total Phenolic Content of Nerium oleander L. Grown in North of Iran  

PubMed Central

In this study, we have examined the antioxidant activity and total phenolic content of different extracts (including water, methanol, water : methanol and acetone) of Nerium oleander L. grown in the north of Iran by employing various in-vitro assay, i.e. DPPH free radical scavenging, reducing power and total antioxidant capacity through the Mo (VI) reduction. The extracts showed different levels of efficacy in each assay in a dose-dependent manner. Methanolic and aqueous methanolic extracts with the highest amount of total phenolic (by using the Folin-Ciocalteu phenol reagent method), were the most potent antioxidant in all of the assays that were used. According to the results of present study, Nerium oleander L. flowers were found to serve as a potential source of natural antioxidants.

Mohadjerani, Maryam

2012-01-01

14

Endophytic fungi from Nerium oleander L (Apocynaceae): main constituents and antioxidant activity  

Microsoft Academic Search

Diverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species.\\u000a These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal\\u000a endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total

Wu-Yang Huang; Yi-Zhong Cai; Kevin D. Hyde; Harold Corke; Mei Sun

2007-01-01

15

Complete atrioventricular block after self-ingestion of Nerium oleander for relief of hemorrhoidal complaints.  

PubMed

Nerium oleander is a plant native only in the Mediterranean region, but it can also be cultivated worldwide, particularly in warm areas. Biologically active oleander compounds may be used for therapeutic purposes. However, when used for self-medication, it may cause serious problems including death. We present a 30-year-old otherwise healthy man who developed complete atrioventricular block after taking a syrup of N. oleander leaves for self-medication to relive hemorrhoidal complaints. The patient was treated by oral administration of charcoal combined with sodium sulfate as well as electrolyte solutions and transient use of an external cardiac pacemaker. The atrioventricular block reverted to sinus rhythm in 30 hours and he was discharged in good hemodynamic status and general condition. PMID:22710590

Küçükdurmaz, Zekeriya; Karapinar, Hekim; Gül, Ibrahim; Yilmaz, Ahmet

2012-03-01

16

Acute toxicity of various oral doses of dried Nerium oleander leaves in sheep.  

PubMed

The acute toxicity of dried Nerium oleander leaves to Najdi sheep is described in 12 sheep assigned as untreated controls, N. oleander-treated once at 1 and 0.25 g/kg body weight and N. oleander-treated daily at 0.06 g/kg body weight by drench. Single oral doses of 1 or 0.25 g of dried N. oleander leaves/kg body weight caused restlessness, chewing movements of the jaws, dyspnea, ruminal bloat, incoordination of movements, limb paresis, recumbency and death 4-24 hr after dosing. Lesions were widespread congestion or hemorrhage, pulmonary cyanosis and emphysema, hepatorenal fatty change and catarrhal abomasitis and enteritis. The daily oral doses of 0.06 g dried N. oleander leaves/kg body weight caused less severe signs and death occurred between days 3 and 14. In these animals, the main lesions were hepatonephropathy and gelatinization of the renal pelvis and mesentry and were accompanied by significant increases in serum AST and LDH activities, in bilirubin, cholesterol and urea concentrations and significant decreases in total protein and albumin levels, anemia and leucopenia. PMID:11789596

Ada, S E; Al-Yahya, M A; Al-Farhan, A H

2001-01-01

17

Implications from a pharmacogenomic analysis: Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats.  

PubMed

Abstract Context: Despite the usage of Nerium oleander L. (Apocynaceae) for anticancer studies and traditional remediation, the regulatory effect of N. oleander leaf distillate on cholesterol metabolism is not disclosed sufficiently. Objective: Cholesterol is an important biological molecule and the synthesis rate is regulated by the amount of cholesterol uptake from the diet. The aim of this study was to investigate the regulation of cholesterol metabolism in response to a high-fat diet (HFD) and the effects of N. oleander leaf distillate-supplemented diet (NOHFD) in rats. Materials and methods: Microarray technology was used to clarify the regulation of cholesterol mechanism in HFD and NOHFD-fed rats (375??g/0.5?mL distilled water applied by gavage). The treatment period was 90 days. Rat liver tissues were used for microarray analysis using the Affymetrix GeneChip Rat Genome platform. Results of groups were statistically analyzed with the Partek 6.6 bioinformatic program. Results: The HFD group exhibited alterations in the expression levels of about 1945 genes with respect to the normal diet (ND) group. The results showed that expression levels of 47 genes were altered related to cholesterol metabolism in HFD and NOHFD groups. The expression levels of seven genes in the NOHFD group were significantly closer to those in the ND group than those of the HFD group. Discussion and conclusion: To conclude, findings suggest that N. oleander leaf distillate-supplemented food has considerable beneficial effects on cholesterol metabolism-related gene expression levels. PMID:24617822

Demirel Kars, Meltem; Odaba??, Burcu Asena; Kars, Gökhan; Uney, Kamil; Ba?c?, Yavuz; Ba?, Ahmet Levent

2014-08-01

18

A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells.  

PubMed

Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the leaves of this plant have already entered phase I clinical trials. In this communication, we have prepared a hydroalcoholic extract from the leaves of Nerium oleander (containing 4.75 ± 0.32 % of cardenolides) and have assessed its cytotoxic activity in A549 lung cancer cells vs. MRC5 nonmalignant lung fibroblasts. The results showed that the cytotoxicity of the Nerium oleander extract against the cancer cell line was significantly higher than that against the nonmalignant cell line, with a potency and selectivity similar to those of the anticancer drug cisplatin. Pretreatment of A549 cells with the antioxidants N-acetylcysteine and catalase slightly prevented the cytotoxicity of the extract, therefore suggesting that the formation of reactive oxygen species participates in its cytotoxic activity but does not play a major role. Nerium oleander extract-induced cytotoxicity and DNA damage (gamma-H2AX focus formation) were slightly higher in cells lacking BRCA2 (deficient in homologous recombination repair) than in parental cells; this indicates that the induction of DNA damage may also play a role in the cytotoxicity of the extract. Nerium oleander extract induced a marked inhibition of glycolysis (glucose consumption and lactate production) in A549 cells, comparable to that of the glycolysis inhibitor dichloroacetate (currently in clinical development for cancer therapy). Because platinum compounds are widely used in the treatment of lung cancer, we tested the cytotoxicity of several combinations of cisplatin with the extract and found a moderate synergism when Nerium oleander extract was administered after cisplatin but a moderate antagonism when it was added before cisplatin. Our results suggest that extracts from Nerium oleander might induce anticancer effects in patients with lung cancer and support their possible advancement into phase II clinical trials for the treatment of this type of cancer. PMID:23824549

Calderón-Montaño, José Manuel; Burgos-Morón, Estefanía; Orta, Manuel Luis; Mateos, Santiago; López-Lázaro, Miguel

2013-08-01

19

Synchrotron radiation X-ray fluorescence analysis of trace elements in Nerium oleander for pollution monitoring  

NASA Astrophysics Data System (ADS)

This works describes the use of synchrotron radiation fluorescence analysis as a technique for monitoring trace elements in bio-indicators for environmental pollution control. The analyses were performed on leaves of Nerium oleander collected in streets with different levels of traffic flow in Rio de Janeiro, Brazil, with one sample from a rural zone. The leaves were collected from adult trees in December and April. The measurement was made with a white beam of synchrotron radiation calibrated with thin samples from MicroMatter. The results indicate that some metals such as Ti, V, Fe and Zn have major content in samples that were collected in places with a high traffic flow, even in the leaves that have been washed. The levels of Mn, Co, Cu and Ni did not show significant differences between the samples. The Pb level also did not vary significantly. This was expected because in Brazil gasoline without Pb has been used for many years. The results seem to indicate that the leaves from Nerium oleander absorb metals from the atmosphere and may be used as an environmental indicator.

de Jesus, E. F. O.; Simabuco, S. M.; dos Anjos, M. J.; Lopes, R. T.

2000-07-01

20

Cardioprotective effect of Nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats.  

PubMed

Nerium oleander Linn (NOL) an evergreen shrub belonging to the Apocynaceae family has been reported to have a wide spectrum of bioactivities. In in vitro study, the free radical scavenging potential of the hydroethanolic extract of N oleander Linn (ENO) flower and its fractions (glycosidic and nonglycosidic) were studied using 2, 2(')-azino-di [3-ethylbenzthiazoline sulphonate] (ABTS(*+) ) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH*) scavenging assay. ENO exhibited better radical scavenging activities than its fractions. Furthermore, the cardioprotective role of ENO (10, 30, 100 mg/kg, per oral [po]) was tested against isoproterenol-induced myocardial toxicity (ISO, 120 mg/kg per day, subcutaneously [sc], for 2 days at 48 hours interval) in experimental rats when compared to propranolol (5 mg/kg, po) which was the standard. Pretreatment with ENO (10, 30, and 100 mg/kg) and propranolol for 2 weeks followed by ISO challenge in rats prevented the elevation of marker enzymes such as lactate dehydrogenase (LDH), ?-glutamyl transferase (GGT), creatine kinase (CK-MB and creatine phosphokinase [CPK]), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in plasma. In addition, pretreatment with ENO and propranolol significantly attenuated the lipid peroxidation by maintaining the levels of enzymatic (superoxide dismutase and glutathione peroxidase) and nonenzymatic antioxidants (reduced glutathione and nitrite), which was also confirmed histologically. Taken together, the current study indicates that the hydroalcoholic extract of N oleander Linn flowers aid in cardioprotection probably by improving the antioxidant defense system during experimental myocardial necrosis. PMID:21191138

Gayathri, Veeraraghavan; Ananthi, Subhash; Chandronitha, Chandranayagam; Ramakrishnan, Ganapathy; Lakshmisundaram, Raman; Sundaram, Raman Lakshmi; Vasanthi, Hannah R

2011-03-01

21

Flavonoid and cardenolide glycosides and a pentacyclic triterpene from the leaves of Nerium oleander and evaluation of cytotoxicity.  

PubMed

A pentacyclic triterpene, oleanderocioic acid, two flavonoidal glycosides, quercetin-5-O-[?-L-rhamnopyranosyl-(1?6)]-?-D-glucopyranoside and kaempferol-5-O-[?-L-rhamnopyranosyl-(1?6)-?-D-glucopyranoside, and a cardenolide, oleandigoside, together with 11 known compounds, were isolated from the leaves of Nerium oleander. Their structures were elucidated on the basis of spectroscopic analysis. The growth inhibitory and cytotoxic activities of eight compounds were evaluated against the MCF-7 human breast cancer cell line using a sulforhodamine B assay. Three compounds, oleandrin, odoroside A and B were further assayed using a panel of 57 human cancer cell lines. PMID:22281382

Siddiqui, Bina Shaheen; Khatoon, Nasima; Begum, Sabira; Farooq, Ahsana Dar; Qamar, Kehkashan; Bhatti, Huma Aslam; Ali, Syed Kashif

2012-05-01

22

Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning.  

PubMed

We present a case of oleander leaf extract poisoning manifested by vomiting, lightheadedness, and heart block. Practicing physicians should understand the potential lethal properties of oleander and its availability throughout the world. PMID:21577379

Khan, Ibraheem; Kant, Chandra; Sanwaria, Anil; Meena, Lokesh

2010-10-01

23

Metal uptake and distribution in cultured seedlings of Nerium oleander L. (Apocynaceae) from the Río Tinto (Huelva, Spain).  

PubMed

Nerium oleander L. (Apocynaceae) is a micro-nano phanerophyte that grows in the riverbanks of the Río Tinto basin (Southwest Iberian Peninsula). The waters and soils of the Río Tinto area are highly acidic and have high concentrations of heavy metals. In this environment, N. oleander naturally grows in both extreme acidic (EA) and less extreme acidic (LEA) water courses, excluding, and bioindicating certain metals. In this work, we compared and evaluated the accumulation preferences and capacities, the distribution and processes of biomineralization of metals (Fe, Cu, Zn, Mn, Mg, Ca) in the first stages of growth of EA and LEA oleanders by means of inductively coupled plasma-mass spectrometry, scanning electron microscopy, and energy dispersive X-ray analyzer analysis. Seeds from both environments were grown and treated with a self-made solution simulating the most extreme red waters from the Río Tinto. LEA plants drastically reduces the metal uptake at the beginning, but later reactivates the uptake reaching concentration values in the same range as the EA plants. The results showed high Mn, Zn and Mg concentrations, accumulation of Fe and Cu in plants from both environments, differing from the metal concentrations of field-grown oleanders. Iron bioformations with traces of other metals were present inside and over epidermal cells and inside vascular cells of stems and roots. They were absent of leaves. The accumulation properties of N. oleander in its early stages of development make it a species to take in consideration in phytoremediation processes but optimized conditions are needed to ensure enough biomass production. PMID:23892697

Franco, Alejandro; Rufo, Lourdes; Zuluaga, Javier; de la Fuente, Vicenta

2013-10-01

24

Nerium oleander indirect leaf photosynthesis and light harvesting reductions after clipping injury or Spodoptera eridania herbivory: high sensitivity to injury.  

PubMed

Variable indirect photosynthetic rate (P(n)) responses occur on injured leaves after insect herbivory. It is important to understand factors that influence indirect P(n) reductions after injury. The current study examines the relationship between gas exchange and chlorophyll a fluorescence parameters with injury intensity (% single leaf tissue removal) from clipping or Spodoptera eridania Stoll (Noctuidae) herbivory on Nerium oleander L. (Apocynaceae). Two experiments showed intercellular [CO(2)] increases but P(n) and stomatal conductance reductions with increasing injury intensity, suggesting non-stomatal P(n) limitation. Also, P(n) recovery was incomplete at 3d post-injury. This is the first report of a negative exponential P(n) impairment function with leaf injury intensity to suggest high N. oleander leaf sensitivity to indirect P(n) impairment. Negative linear functions occurred between most other gas exchange and chlorophyll a fluorescence parameters with injury intensity. The degree of light harvesting impairment increased with injury intensity via lower (1) photochemical efficiency indicated lower energy transfer efficiency from reaction centers to PSII, (2) photochemical quenching indicated reaction center closure, and (3) electron transport rates indicated less energy traveling through PSII. Future studies can examine additional mechanisms (mesophyll conductance, carbon fixation, and cardenolide induction) to cause N. oleander indirect leaf P(n) reductions after injury. PMID:22325884

Delaney, Kevin J

2012-04-01

25

Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model.  

PubMed

The present study is aimed to assess the therapeutic potential of sulfonylurea drug glimepiride in comparison with Nerium oleander plant extract on insulin, glucose levels and some liver enzymes activities in streptozotocin-induced diabetic rats. Rats were rendered diabetic by intraperitoneal injection of a single dose of 50 mg kg(-1) body weight streptozotocin. Rats with serum glucose levels > 200 mg dL(-1) were subdivided into three sub-groups: the first sub-group were remained without treatment and considered as diabetics. The second and third subgroups were orally administered 0.1 mg kg(-1) body weight/day glimepiride and 250 mg kg(-1) body weight/day Nerium oleander, respectively for 4 weeks. Streptozotocin-induced diabetic rats showed hypoinsulinemia and hyperglycemia compared to controls. Strong negative correlation (r = -0.8) was found between serum insulin and glucose levels in diabetic rats. This correlation was +0.4 and -0.3 in glimepiride and Nerium olender-treated rats, respectively implying that glimepiride and plant extract improved insulin and glucose levels with the former was more efficient. The activities of serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were significantly increased in streptozotocin-induced diabetic rats compared to controls. Treatment of diabetic rats with glimepiride or Nerium oleander extract also improved liver enzymes activities. PMID:22514888

Mwafy, Saleh N; Yassin, Maged M

2011-11-01

26

The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts.  

PubMed

Cardiovascular diseases are increasingly becoming one of the leading diseases causing morbidity and mortality in Uganda. Ethnographic evidence suggests that these diseases are often first managed by indigenous and related herbs before patients are referred for allopathic forms of management. One such herb of interest is Nerium oleander. Therefore the crude ethanolic extracts of the dried leaves of this herb were tested against the following parameters in the isolated guinea pig hearts: force of contraction, heart rate and cardiac flow. The extracts brought about dose-dependent increases in all these parameters from their baseline readings. Compared with graded doses of digoxin the effects closely mirrored the activities in a dose dependent manner. At the mechanism of action level, it would appear the extract works in the same as digoxin since their dose-contraction-response curves are parallel. This finding would tend to provide a strong rationale for the herb's traditional use in cardiovascular illness. PMID:12913798

Adome, R O; Gachihi, J W; Onegi, B; Tamale, J; Apio, S O

2003-08-01

27

Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats.  

PubMed

Diabetes was induced by intraperitoneal injection of streptozotocin (35?mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375??g/0.5?mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6?mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor- (PPAR-) ?, ?, and ? in adipose tissue and PPAR-?-? in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375??g/0.5?mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes. PMID:23251156

Bas, Ahmet Levent; Demirci, Sule; Yazihan, Nuray; Uney, Kamil; Ermis Kaya, Ezgi

2012-01-01

28

Nerium oleander Distillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats  

PubMed Central

Diabetes was induced by intraperitoneal injection of streptozotocin (35?mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375??g/0.5?mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6?mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated-receptor- (PPAR-) ?, ?, and ? in adipose tissue and PPAR-?–? in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375??g/0.5?mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes.

Bas, Ahmet Levent; Demirci, Sule; Yazihan, Nuray; Uney, Kamil; Ermis Kaya, Ezgi

2012-01-01

29

The structure of a new cardenolide diglycoside and the biological activities of eleven cardenolide diglycosides from Nerium oleander.  

PubMed

A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2-11. The structure of compound 1 was established on the basis of their spectroscopic data. The in vitro anti-inflammatory activity of compounds 1-11 was examined on the basis of inhibitory activity against the induction of the intercellular adhesion molecule-1 (ICAM-1). Compounds 2-5 were active at an IC(50) value of less than 0.8 µM. The cytotoxicity of compounds 1-11 was evaluated against three human cell lines normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), and human liver tumor cells (HepG2). Compound 3 was active toward VA-13 cells, and compounds 2-5 were active toward HepG2 cells at IC(50) values of less than 1.3 µM. The multidrug resistance (MDR)-reversal activity of compounds 1-11 was evaluated on the basis of the amount of calcein in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1 and 8 showed moderate effects on calcein accumulation. PMID:21372420

Zhao, Ming; Bai, Liming; Toki, Asami; Hasegawa, Ryo; Sakai, Jun-ichi; Hasegawa, Toshiaki; Ogura, Hirotsugu; Kataoka, Takao; Bai, Yuhua; Ando, Mariko; Hirose, Katsutoshi; Ando, Masayoshi

2011-01-01

30

The Nerium oleander aphid Aphis nerii is tolerant to a local isolate of Aphid lethal paralysis virus (ALPV).  

PubMed

In a survey that was conducted during the year 2011, a local strain of Aphid lethal paralysis virus (ALPV) was identified and isolated from a wild population of Aphis nerii aphids living on Nerium oleander plants located in northern Israel. The new strain was tentatively named (ALPV-An). RNA extracted from the viral particles allowed the amplification and determination of the complete genome sequence. The virus genome is comprised of 9835 nucleotides. In a BLAST search analysis, the ALPV-An sequence showed 89 % nucleotide sequence identity with the whole genome of a South African ALPV and 96 and 94 % amino acid sequence identity with the ORF1 and ORF2 of that strain, respectively. In preliminary experiments, spray-applied, purified ALPV virions were highly pathogenic to the green peach aphid Myzus persicae; 95 % mortality was recorded 4 days post-infection. These preliminary results demonstrate the potential of ALPV for use as a biologic agent for some aphid control. Surprisingly, no visible ALPV pathogenic effects, such as morphological changes or paralysis, were observed in the A. nerii aphids infected with ALPV-An. The absence of clear ALPV symptoms in A. nerii led to the formulation of two hypotheses, which were partially examined in this study. The first hypothesis suggest that A. nerii is resistant or tolerant of ALPV, while the second hypothesis propose that ALPV-An may be a mild strain of ALPV. Currently, our results is in favor with the first hypothesis since ALPV-An is cryptic in A. nerii aphids and can be lethal for M. persicae aphids. PMID:23229204

Dombrovsky, Aviv; Luria, Neta

2013-04-01

31

Oleander toxicity: an examination of human and animal toxic exposures  

Microsoft Academic Search

The oleander is an attractive and hardy shrub that thrives in tropical and subtropical regions. The common pink oleander, Nerium oleander, and the yellow oleander, Thevetia peruviana, are the principle oleander representatives of the family Apocynaceae. Oleanders contain within their tissues cardenolides that are capable of exerting positive inotropic effects on the hearts of animals and humans. The cardiotonic properties

Shannon D. Langford; Paul J. Boor

1996-01-01

32

Platinum and rhodium associated with the leaves of Nerium oleander L.; analytical method using voltammetry; assessment of air quality in the Palermo (Italy) area.  

PubMed

A rapid accumulation of the catalytic active noble metals in the environmental and biological matrices was observed and concern arose about potential environmental and health risks. The development of reliable analytic methods to measure very low Pt and Rh concentrations is required. The main purpose of this work was to develop a reliable method for the determination of Pt and Rh in environmental matrices because of inherent difficulties in using conventional techniques used, in particular, the ICP-OES technique. A direct determination of Pt using ICP-MS, for instance, is problematic, due to interfering signals. In this work, differential pulse voltammetry (DPV/a) and adsorptive stripping voltammetry (AdSV) were used for the determination of Pt and Rh in Nerium oleander leaves. Pt and Rh concentrations were found in the ranges 0.33-25 and 0.40-4.6 microg/kg d.w., respectively. We carried out linear regression analysis between total PAH concentrations in leaves of oleander and of Quercus ilex measured in previous researches and the data obtained in this work. The high correlation coefficients were obtained; which demonstrates that oleander leaves can be used to establish the presence and the distribution of pollutants in a chosen area. PMID:19846253

Orecchio, Santino; Amorello, Diana

2010-02-15

33

Oleander tea: herbal draught of death.  

PubMed

A woman died after drinking herbal tea prepared from oleander (Nerium oleander) leaves. This case demonstrates the cross-reactivity between the cardiac glycosides in oleander and the digoxin radioimmunoassay. Digoxin-specific Fab antibody fragments have not been used in oleander poisoning, but these might prove to be lifesaving. Treatment of oleander toxicity is aimed at controlling arrhythmias and hyperkalemia; inactivation of the Na-K ATPase pump, however, can make treatment difficult. PMID:4039113

Haynes, B E; Bessen, H A; Wightman, W D

1985-04-01

34

Effect of Nerium oleander (N.O.) leaves extract on serum hepcidin, total iron, and infiltration of ED1 positive cells in albino rat.  

PubMed

To gain insight into the hepatohistological alterations in noninjured rat liver, Nerium oleander (N.O.) leaves extract was injected intramuscularly to induce an acute phase reaction (APR). Histopathological changes were studied after 3, 12, and 24 h time course of sterile muscle abscess. Tissue integrity and any infiltration of inflammatory cells in the liver were investigated by Hematoxylin and Eosin and ED1 peroxidase stainings. The administration of N.O. leaves extract (10 mL/kg) in H & E stained sections showed a general vacuolization of cytoplasm resulting loss of polarity with prominent nucleoli after 3 h of induction. At 12 h, eccentric nuclei were also observed in the sections. Marked infiltration of leucocytes with predominate macrophages was also found after 24 h as seen by ED1 positive staining. In the present study, a possible relationship between serum hepcidin and total iron level was also investigated in vivo. An early increase of hepcidin and total iron level (3 h) with a maximum at 12 h (P < 0.01; P < 0.001) was observed. These changes indicate that sterile muscle abscess may induce APR resulting in hepatic damage which is evident with the recruitment of inflammatory cells into the organ. PMID:24069586

Abbasi, Muddasir Hassan; Fatima, Sana; Naz, Naila; Malik, Ihtzaz A; Sheikh, Nadeem

2013-01-01

35

In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.  

PubMed

The principal active constituent of the botanical drug candidate PBI-05204, a supercritical CO(2) extract of Nerium oleander, is the cardiac glycoside oleandrin. PBI-05204 shows potent anticancer activity and is currently in phase I clinical trial as a treatment for patients with solid tumors. We have previously shown that neriifolin, which is structurally related to oleandrin, provides robust neuroprotection in brain slice and whole animal models of ischemic injury. However, neriifolin itself is not a suitable drug development candidate and the FDA-approved cardiac glycoside digoxin does not cross the blood-brain barrier. We report here that both oleandrin as well as the full PBI-05204 extract can also provide significant neuroprotection to neural tissues damaged by oxygen and glucose deprivation as occurs in ischemic stroke. Critically, we show that the neuroprotective activity of PBI-05204 is maintained for several hours of delay of administration after oxygen and glucose deprivation treatment. We provide evidence that the neuroprotective activity of PBI-05204 is mediated through oleandrin and/or other cardiac glycoside constituents, but that additional, non-cardiac glycoside components of PBI-05204 may also contribute to the observed neuroprotective activity. Finally, we show directly that both oleandrin and the protective activity of PBI-05204 are blood brain barrier penetrant in a novel model for in vivo neuroprotection. Together, these findings suggest clinical potential for PBI-05204 in the treatment of ischemic stroke and prevention of associated neuronal death. PMID:21950737

Dunn, Denise E; He, Dong Ning; Yang, Peiying; Johansen, Mary; Newman, Robert A; Lo, Donald C

2011-11-01

36

Response to water stress of some oleander cultivars suitable for pot plant production  

Microsoft Academic Search

Oleander (Nerium oleander L.) is an evergreen shrub of great ornamental interest which, in recent times, has been increasingly used as a flowering pot plant. Plants grown in pots undergo more frequent water stress conditions than those grown in the soil, due to the limited volume of substrate available for the roots. Oleander is a species adaptable to dry conditions

Anna Lenzi; Lambros Pittas; Tommaso Martinelli; Piero Lombardi; Romano Tesi

2009-01-01

37

Unexpected double lethal oleander poisoning.  

PubMed

Nerium oleander is a very popular urban ornamental plant in Europe, but it is also extremely dangerous because it contains several types of glycosides, accidental ingestion of which can cause cardiac arrhythmias and even deaths. The rarity of such cases makes it difficult to think of oleander poisoning without evidences that suggest this possibility as the cause of the unexpected death. This report concerns the discovery of the bodies of 2 young people, a man and a woman, in a forest in conditions of extreme malnutrition. Medicolegal investigations showed neither pathologic nor traumatic causes of death, but the presence of vegetal remains in the stomach was noticed. A common toxicological analysis resulted negative, but the implementation of more detailed investigations showed the presence of digoxin in the blood of both cadavers, excluding the possibility of a pharmaceutical provenience of digoxin, this laboratory result was interpreted as evidence of ingestion of oleander, which contains oleandrine, the cross reaction of which with digoxin is widely described in the literature. Identification of the 2 subjects, which occurred after 4 years, strengthened the hypothesis of accidental poisoning by oleander because it was ascertained that the 2 young people were vegans--extreme vegetarians who reject the ingestion of foods of animal origin and live by eating only what they find in nature. PMID:21926903

Papi, Luigi; Luciani, Alessandro Bassi; Forni, David; Giusiani, Mario

2012-03-01

38

The effect of urban ground cover on microclimate, growth and leaf gas exchange of oleander in Phoenix, Arizona  

Microsoft Academic Search

We assessed how small patches of contrasting urban ground cover [mesiscape (turf), xeriscape (gravel), concrete, and asphalt] altered the microclimate and performance of adjacent oleander ( Nerium oleander L.) plants in Phoenix, Arizona during fall\\/winter (September–February) and spring\\/summer (March–September). Ground-cover and oleander canopy surface temperatures, canopy air temperatures and pot soil temperatures tended to be lowest in the mesiscape and

Erin C. Mueller; Thomas A. Day

2005-01-01

39

The effect of urban ground cover on microclimate, growth and leaf gas exchange of oleander in Phoenix, Arizona  

Microsoft Academic Search

We assessed how small patches of contrasting urban ground cover [mesiscape (turf), xeriscape (gravel), concrete, and asphalt] altered the microclimate and performance of adjacent oleander (Nerium oleander L.) plants in Phoenix, Arizona during fall\\/winter (September February) and spring\\/summer (March September). Ground-cover and oleander canopy surface temperatures, canopy air temperatures and pot soil temperatures tended to be lowest in the mesiscape

Erin C. Mueller; Thomas A. Day

2005-01-01

40

Effect of selected insecticides on Homalodisca coagulata (Homoptera: Cicadellidae) and transmission of oleander leaf scorch in a greenhouse study.  

PubMed

Homalodisca coagulata (Say) is a recent introduction to California. It is known to spread a strain of the bacterium Xylella fastidiosa Wells, Raju, Hung, Weisberg, Mandelco-Paul & Brenner that induces oleander leaf scorch disease in oleander, Nerium oleander L. Oleander leaf scorch is lethal to oleander and threatens to decimate one of the most important landscape shrubs in California. Towards developing a management strategy for H. coagulata-spread oleander leaf scorch, we documented the affects of selected insecticides on H. coagulata mortality, feeding behavior, and disease transmission in a greenhouse study. Oleanders treated with fenpropathrin, fenpropathrin + acephate, and imidacloprid caused significant mortality to caged H. coagulata within 4 h of exposure. Within 24 h, these pesticides caused nearly 100% mortality 3 wk after treatment. In other experiments, acetamiprid and fenpropathrin treatments reduced time spent feeding and total time on plants. H. coagulata on fenpropathrin-, acetamiprid-, and imidacloprid-treated oleander died in less than 13 min on average. Oleander leaf scorch transmission by H. coagulata was blocked by applications of foliar-applied acetamiprid, and soil-applied imidacloprid and thiamethoxam. PMID:11681662

Bethke, J A; Blua, M J; Redak, R A

2001-10-01

41

Fatal oleander poisoning.  

PubMed

A case of fatal poisoning due to the presumed ingestion of leaves and/or fruit of the yellow oleander (Thevetia peruviana) is described. The diagnosis was confirmed by radioimmunoassay using antibodies of differential specificity towards cardiac glycosides. Attention is drawn to the potential usefulness of digoxin assay in suspected cases of oleander poisoning. PMID:7195456

Ansford, A J; Morris, H

1981-04-01

42

The effect of urban ground cover on microclimate, growth and leaf gas exchange of oleander in Phoenix, Arizona  

NASA Astrophysics Data System (ADS)

We assessed how small patches of contrasting urban ground cover [mesiscape (turf), xeriscape (gravel), concrete, and asphalt] altered the microclimate and performance of adjacent oleander (Nerium oleander L.) plants in Phoenix, Arizona during fall/winter (September February) and spring/summer (March September). Ground-cover and oleander canopy surface temperatures, canopy air temperatures and pot soil temperatures tended to be lowest in the mesiscape and highest in the asphalt and concrete. Canopy air vapor pressure deficits were lowest in the mesiscape and highest in the asphalt plot. Rates of net photosynthesis of all oleander plants were highest in October and May, and declined through mid-summer (June July), when rates tended to be highest in the cooler mesiscape, particularly when water was limiting. During fall/winter, oleanders in the mesiscape produced 20% less biomass, 13% less leaf area, and had 12% lower relative growth rates (RG) than those in the other ground covers. Lower nighttime temperatures in the mesiscape in December led to oleander frost damage. During spring/summer, oleanders in the mesiscape produced 11% more biomass, 16% more leaf area, and had 3% higher RG than those in the other cover types. The effects of urban ground cover on oleander performance were season-specific; while oleander growth was greatest in the mesiscape during spring/summer, it was lowest during fall/winter and these plants experienced frost damage. Because all oleander plants produced >10 times as much biomass during the spring/summer, on an annual basis oleanders in the mesiscape produced 5 11% more biomass than plants in the warmer ground covers.

Mueller, Erin C.; Day, Thomas A.

2005-03-01

43

The effect of urban ground cover on microclimate, growth and leaf gas exchange of oleander in Phoenix, Arizona.  

PubMed

We assessed how small patches of contrasting urban ground cover [mesiscape (turf), xeriscape (gravel), concrete, and asphalt] altered the microclimate and performance of adjacent oleander (Nerium oleander L.) plants in Phoenix, Arizona during fall/winter (September-February) and spring/summer (March-September). Ground-cover and oleander canopy surface temperatures, canopy air temperatures and pot soil temperatures tended to be lowest in the mesiscape and highest in the asphalt and concrete. Canopy air vapor pressure deficits were lowest in the mesiscape and highest in the asphalt plot. Rates of net photosynthesis of all oleander plants were highest in October and May, and declined through mid-summer (June-July), when rates tended to be highest in the cooler mesiscape, particularly when water was limiting. During fall/winter, oleanders in the mesiscape produced 20% less biomass, 13% less leaf area, and had 12% lower relative growth rates (R(G)) than those in the other ground covers. Lower nighttime temperatures in the mesiscape in December led to oleander frost damage. During spring/summer, oleanders in the mesiscape produced 11% more biomass, 16% more leaf area, and had 3% higher R(G) than those in the other cover types. The effects of urban ground cover on oleander performance were season-specific; while oleander growth was greatest in the mesiscape during spring/summer, it was lowest during fall/winter and these plants experienced frost damage. Because all oleander plants produced >10 times as much biomass during the spring/summer, on an annual basis oleanders in the mesiscape produced 5-11% more biomass than plants in the warmer ground covers. PMID:15726447

Mueller, Erin C; Day, Thomas A

2005-03-01

44

Electrocardiographic changes during inhalational oleander toxicity.  

PubMed

Inhalational oleander toxicity was considered in a family of 4 by history of exposure to smoke from burning oleander twigs. Electrocardiography revealed first- and second-degree atrioventricular block with digoxin-like ST-T-wave changes, suggestive of oleander toxicity in the absence of exposure to digoxin or other herbal medicines, and without systemic illness. Complete blood count, biometabolic profile, chest x-ray, and echocardiography did not reveal any abnormalities. Electrocardiographies normalized within 4 days when kept away from offending agents. Because oleander plant materials are used for burning, people are exposed to inhalational oleander toxicity. Hence, practitioners shall consider such poisonings in them. PMID:21397908

Senthilkumaran, Subramanian; Meenakshisundaram, Ramachandran; Michaels, Andrew D; Thirumalaikolundusubramanian, Ponniah

2011-01-01

45

Structural characterization of a pectic polysaccharide from Nerium indicum flowers.  

PubMed

A polysaccharide fraction, J6, was isolated from the hot-water extract of flowers of oleander Nerium indicum Mill., using ethanol precipitation, cetyltrimethylammonium bromide (CTAB) complexing, anion-exchange chromatography and gel permeation chromatography. J6 was found to contain L-rhamnose, L-arabinose, D-galactose, and D-galacturonic acid, in the ratio of 10.1:49.8:30.1:10.0. Its structure was investigated by methylation analysis, periodate oxidation, Smith degradation, partial acid hydrolysis, electrospray ionization mass spectrometry and NMR spectroscopic methods. It was found that J6 is an RG-I type polysaccharide, which contains a rhamnogalacturonan backbone, with various branches attached to O-4 of L-rhamnose. The branches probably involve (1-->4)-beta-D-galactan, branched L-arabino-(1-->3)(1-->6)-beta-D-galactan, and (1-->5)-alpha-L-arabinan. J6 stimulated NO production of macrophage RAW264.7 cells in a preliminary test. PMID:20573364

Dong, Qun; Liu, Xuan; Yao, Jian; Dong, Xiaotang; Ma, Chao; Xu, Yuxia; Fang, Jinian; Ding, Kan

2010-08-01

46

Beneficial effect of digoxin-specific Fab antibody fragments in oleander intoxication.  

PubMed

A 24-year-old man presented to the emergency department with nausea, vomiting, abdominal pain, and an acute confusional state of 6 hours' duration. Ten hours before admission, he had ingested a mixture of orange juice and six ground leaves, later identified as Nerium oleander (common pink oleander) leaves. His blood pressure was 100/80 mm Hg, and his pulse rate was irregular at 40/min. He was disoriented and his speech was dysarthric. Twelve-lead electrocardiography revealed a complete atrioventricular block, with a nodal escape rhythm of 40/min and diffuse ST depression. The presumptive diagnosis of acute oleander intoxication was confirmed by the detection of digoxin (1.0 nmol/L [0.8 ng/mL]) on radioimmunoassay. Despite intensive therapy, the patient's hemodynamic condition deteriorated. His blood pressure decreased to 70/40 mm Hg; he became oliguric and nonresponsive to external stimuli; and his potassium concentration rose to 6.8 mmol/L. Eighteen hours after admission, an empiric 480-mg dose of digoxin-specific Fab antibody fragments was administered intravenously over 30 minutes. Within minutes of the initiation of immunotherapy, the patient woke up; his blood pressure rose to 90/50 mm Hg; and he regained a sinus rhythm of 68/min with a prolonged PR interval. His potassium concentration decreased to 5.1 mmol/L within 15 minutes and normalized within 1 hour of therapy initiation. One day later, the 1 degree atrioventricular block disappeared, but the ST depression persisted for an additional 6 days. The value of digoxin-specific Fab antibody fragments in the treatment of plant glycoside and, in particular, oleander intoxication is discussed. PMID:7575073

Safadi, R; Levy, I; Amitai, Y; Caraco, Y

1995-10-23

47

Oleander interference in the digoxin radioimmunoassay in a fatal ingestion.  

PubMed

An elderly woman allegedly ingested oleander leaves and died. Ventricular arrhythmias and asystole were unresponsive to cardiopulmonary resuscitation, pharmacologic agents, and cardioversion. The patient, who had no access to digoxin, had an initial serum digoxin concentration of 5.8 ng/mL. Cross-reactivities between oleander extract and pure oleandrin and digoxin in the digoxin radioimmunoassay were 100:1 and 29,000:1, respectively. We postulate that glycosides in oleander leaves produced the elevated serum digoxin concentration. Based on an assumed volume of distribution of the oleander glycosides of 1 L/kg, the calculated lethal dose absorbed by our patient was 200 times greater than lethal doses in several animal species and corresponded to the absorption of 4 g of oleander leaves. PMID:7038154

Osterloh, J; Herold, S; Pond, S

1982-03-19

48

Nematicidal cardenolides from Nerium indicum Mill.  

PubMed

Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) and cardenolide N-1 (3). The median lethal concentrations (LC(50)) of compounds 1-3 against the nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, and Caenorhabditis elegans at 72 h were 103.3, 49.0, and 45.4 mg l(-1), 257.0, 62.7, and 177.8 mg l(-1), and 242.9, 29.1, and 41.7 mg l(-1), respectively. This is the first report about the nematicidal activity of cardenolides. PMID:19319871

Wang, Xing-Biao; Li, Guo-Hong; Zheng, Li-Jun; Ji, Kai-Yan; Lü, Hua; Liu, Fang-Fang; Dang, Li-Zhi; Mo, Ming-He; Zhang, Ke-Qin

2009-03-01

49

A case of non-fatal oleander poisoning  

PubMed Central

We present a case of non-fatal poisoning with oleander blooms in a 42-year-old woman. After repeated vomiting and gastrointestinal distress, the patient was admitted to the hospital with cardiac symptoms 4 h after the ingestion. Urine and blood samples were assayed for drugs of abuse and for general toxicological screen. Blood was analysed for alcohol and volatiles. Oleandrin was detected in the blood sample at a concentration of 14.7 ng/ml. Following a review of the literature, this is the first case of oleander poisoning in which the patient recovered with only conservative treatment. Oleander poisonings occur rarely, and generally result in death.

Al, Behcet; Yarbil, P?nar; Dogan, Mehmet; Kabul, Sinem; Y?ld?r?m, Cuma

2010-01-01

50

Cutaneous absorption of Oleander: Fact or fiction  

PubMed Central

Cardiac conduction disorders following oral ingestion of Oleander plant materials were documented earlier. Transcutaneous absorption of yellow oleander (Thevetia peruviana) leaf extract applied over non intact skin (raw wound) resulting in reversible cardiac conduction disorder observed in four healthy males who were free from any other systemic or electrolyte or metabolic disorders or exposure to pesticide or toxins is reported for the first time. Their hematological, biochemical, clinical, and echocardiogram status were within normal limits and free of any abnormalities. One among the four, presented for weakness and breathlessness (class II). He had bradycardia with Mobitz II block and hypotension without any other demonstrable localizing signs. The other three were identified in the community and without any symptoms. However, their ECG revealed bradycardia with Mobitz I block in two and complete heart block in the other. All of the four recovered well without any untoward events. Hence, it is suggested that physicians and practitioners have to elicit history and route of administration of unconventional therapy, whenever they are confronted with clinical challenges and during medical emergencies before embarking final decision.

Senthilkumaran, S; Saravanakumar, S; Thirumalaikolundusubramanian, P

2009-01-01

51

Specific detection and identification of Xylella fastidiosa strains causing oleander leaf scorch using polymerase chain reaction.  

PubMed

A pair of PCR primers, QH-OLS05/QH-OLS08 specific for strains of Xylella fastidiosa causing oleander leaf scorch was developed. The primers were designed according to a DNA sequence of a randomly amplified polymorphic DNA (RAPD)-polymerase chain reaction (PCR) product unique to oleander strains. The PCR assay using primer pair QH-OLS05/QH-OLS08 allowed quick and simple detection and identification of oleander strains in cultured bacterium and infected plant samples. The assay also can be applied to insect samples. Specific detection and identification of oleander strains of X. fastidiosa by PCR is useful for epidemiologic and etiologic studies of oleander leaf scorch by identifying what plants and insect vectors harbor or carry this particular strain of X. fastidiosa, especially in locations where mixed natural infections by oleander and other strains of X. fastidiosa occur. PMID:19020933

Huang, Qi

2009-04-01

52

Controlling the Spread of XYLELLA FASTIDIOSA, the Causal Agent of Oleander Leaf Scorch, by Disrupting Vector Acquisition and Transmission.  

National Technical Information Service (NTIS)

Oleander Leaf Scorch (OLS) is a devastating disease of oleander induced by the bacterium Xylella fastidiosa. The Glassy-winged Sharpshooter (GWSS, Homalodisca coagulate) spreads the OLS bacterium during feeding by first acquiring it from infected plants a...

M. J. Blua R. A. Redak H. S. Costas

2002-01-01

53

75 FR 5074 - Oleander Power Project, LP; Southern Company-Florida LLC; Notice of Filing  

Federal Register 2010, 2011, 2012, 2013

...Commission [Docket Nos. ER00-3240-016; ER01-1633-013] Oleander Power Project, LP; Southern Company-Florida LLC; Notice...January 22, 2010. Take notice that on January 14, 2010, Oleander Power Project, LP and Southern Company-Florida LLC...

2010-02-01

54

Rapid detection of oleander poisoning by Dimension Vista digoxin assay (Flex Reagent Cartridge).  

PubMed

Oleander poisoning can be detected by digoxin immunoassays and for last two decades the fluorescence polarization immunoassay (FPIA) has been used for rapid detection of oleander poisoning in clinical laboratories. Recently, Abbott Laboratories (Abbott Park, IL) discontinued this assay. Therefore, we explored the possibility of using another digoxin assay (Dimension Vista Flex Reagent Cartridge, Tina Quant, EMIT 2000 and old FPIA assay for comparison) for rapid detection of oleander poisoning. When aliquots of drug-free serum pools were supplemented with pure oleandrin or oleander extract, we observed the highest apparent digoxin values using Dimension Vista digoxin assay (Flex Reagent Cartridge). We also observed significant apparent digoxin values in vivo in sera of mice both 1 and 2 ?hr after feeding with oleander extract. When a serum pool prepared from patients taking digoxin was further supplemented with various amounts of oleander extract, the highest falsely elevated digoxin values were observed with Dimension Vista digoxin assay. Monitoring free digoxin using Dimension Vista digoxin assay (Flex Reagent Cartridge) did not eliminate this interference. Digibind neutralized digoxin-like factors of oleander extract and such effect can be monitored by observing significant reduction in apparent free digoxin levels in the presence of Digibind as measured in the protein-free ultrafiltrate using Dimension Vista digoxin assay (Flex Reagent Cartridge). PMID:21438002

Dasgupta, Amitava; Klein, Kimberley; Risin, Semyon A; Actor, Jeffrey K

2011-01-01

55

The new enzyme-linked immunosorbent digoxin assay on the ADVIA Integrated Modular System is virtually free from oleander interference.  

PubMed

Despite known toxicity of oleander, this product is used in herbal preparations. Oleander interferes with various digoxin immunoassays. It is possible that a person taking digoxin also may take oleander-containing herbal products, and digoxin immunoassays interfering with oleander cannot be used for therapeutic monitoring of digoxin. Recently, Bayer Diagnostics introduced a new enzyme-linked chemiluminescent immunosorbent digoxin assay for application on the ADVIA IMS System (ECLIA-digoxin). We studied potential interference of oleander with this new digoxin assay and found that this assay is virtually free from oleander interference. When aliquots of drug-free serum pools were supplemented with ethyl alcohol extract of oleander leaf or pure oleandrin standard, we observed significant apparent digoxin concentration when measured by the fluorescence polarization immunoassay (FPIA) but minimal digoxin-like immunoreactivity using the ECLIA digoxin assay. Because cross-reactivity should be studied in the presence of primary analyte, we prepared 2 serum pools using sera from patients receiving digoxin. Then aliquots of first digoxin pool were supplemented with oleandrin standard and aliquots of second digoxin pool with oleander extract. We observed significant increases in apparent digoxin concentration in the presence of both oleandrin and oleander extract using the FPIA. However, we observed no statistically significant change in digoxin concentration when ECLIA digoxin assay was used, indicating that this assay is virtually free from oleander interference. PMID:16628146

Dasgupta, Amitava; Kang, Edward; Datta, Pradip

2006-04-01

56

Synthesis of oligosaccharide fragments of the rhamnogalacturonan of Nerium indicum.  

PubMed

Three trisaccharides, one pentasaccharide, and one heptasaccharide, namely ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (1), ?-L-Rha-(1?4)-?-D-GalA-(1?4)-?-D-GalA-OC3H7 (2), ?-D-GalA-(1?4)-?-D-GalA-(1?2)-?-L-Rha-OC3H7 (3), ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (4), and ?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-(1?2)-?-L-Rha-(1?4)-?-D-GalA-OC3H7 (5), which are relevant to the fragments of the rhamnogalacturonan of Nerium indicum, were concisely synthesized. The syntheses feature highly stereoselective formation of the ?-D-GalA-linkage with GalA N-phenyltrifluoroacetimidates as donors. PMID:23811084

Ma, Yuyong; Cao, Xin; Yu, Biao

2013-08-01

57

Detoxification of Nerium indicum roots based on Indian system of medicine: phytochemical and toxicity evaluations.  

PubMed

Indian system of medicine describes the usage of certain very toxic plant based drugs after performing a detoxification process (Shodhana samskara). Nerium indicum is traditionally used as a medicine though known to cause severe allergic symptoms, tachycardia and gastrointestinal effects leading to fatalities. In this study, the detoxification (shodhana) for Nerium indicum was scientifically validated based on phytochemical and toxicity profiles. Shodhana was performed according to traditional literature. HPTLC densitometric studies were performed for the pre- and post-shodhana powders followed by sub-acute toxicity evaluation in rats. Preparative TLC and LC-MS showed the reduction of oleandrin peak in the post-shodhana sample. Prominent features of cardiotoxicity including tachycardia were noted in the pre-shodhana Nerium treated animals along with mortality. However, no such toxicity was encountered in the post-shodhana Nerium treated animals. Hence, using the recommended detoxification (shodhana), the toxicity of an important medicinal plant was significantly nullified. Such studies provide a scientific support towards our traditional medicinal practices using modem analytical and experimental methodologies and may prove to be very useful in establishing standard scientific procedures for routine and safe use of traditional medicines. PMID:22125956

Banerjee, Aryamitra A; Vasu, Kamala K; Pancholi, Harit; Rajani, Mandapati; Nivsarkar, Manish A

2011-01-01

58

Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds.  

PubMed

Thevetia cardiac glycosides can lead to intoxication, thus they are important indicators for forensic and pharmacologic surveys. Six thevetia cardiac glycosides, including two with unknown structures, were isolated from the seeds of the Yellow Oleander (Thevetia peruviana (Pers.) K. Shum., Apocynaceae). LC-ESI?-MS(/MS) analysis under high-resolution conditions used as a qualitative survey of the primary glycosides did not lead to fragmentation of the aglycones. Acid hydrolysis of the polar and non-volatile thevetia glycosides under severe conditions yielded the aglycones of the thevetia glycosides and made them amenable to GC-MS analysis. Comparison of mass spectral fragmentation patterns of the aglycones, as well as high-resolution mass spectrometric and NMR data of four of the primary thevetia glycosides including the two unknowns, revealed the structures of the complete set of six thevetia glycosides. The identified compounds are termed thevetin C and acetylthevetin C and differ by an 18,20-oxido-20,22-dihydro functionality from thevetin B and acetylthevetin B, respectively. The absence of an unsaturated lactone ring renders the glycosides cardio-inactive. The procedures developed in this study and the sets of analytical data obtained will be useful for screening and structure assessment of other, particularly polar, cardiac glycosides. PMID:22196940

Kohls, Sarah; Scholz-Böttcher, Barbara M; Teske, Jörg; Zark, Patrick; Rullkötter, Jürgen

2012-03-01

59

Rapid detection of oleander poisoning using digoxin immunoassays: comparison of five assays.  

PubMed

Oleander is an ornamental shrub that grows in the United States, Australia, India, Sri Lanka, China, and other parts of the world. All parts of the plant are poisonous because the presence of cardiac glycoside oleandrin. Despite its toxicity, oleander extract is used in folk medicines. Because of its structural similarity, oleandrin cross-reacts with the fluorescence polarization immunoassay (FPIA) for digoxin. We studied the potential of detecting oleandrin in serum using 5 common digoxin immunoassays (FPIA, MEIA, both from Abbott; Beckman digoxin assay on Synchron LX, Chemiluminescent assay, CLIA from Bayer Diagnostics) and a recently FDA-approved turbidimetric assay on the ADVIA 1650 analyzer (Bayer). Aliquots of drug-free and digoxin-like immunoreactive substances (DLIS)-free serum pools were supplemented with ethanol extract of oleander leaves or oleandrin (Sigma Chemicals) in amounts expected in vivo after severe overdose. We observed significant apparent digoxin concentration with FPIA, Beckman, and the new turbidimetric assay (1 mL drug-free serum supplemented with 5.0 microL of oleander extract: apparent digoxin 2.36 ng/mL by the FPIA, 0.32 ng/mL by the MEIA, 0.93 ng/mL by the Beckman, 0.82 ng/mL by the new turbidimetric assay). The CLIA showed no cross-reactivity. Similar observations were made when serum pools were supplemented with oleandrin. Because cross reactivity should be tested in the presence of the primary analyte, we supplemented serum pools prepared from patients receiving digoxin with oleander extract or oleandrin. The measured digoxin concentrations were falsely elevated with the FPIA, Beckman, and turbidimetric assays, the highest false elevation being observed with the FPIA. Surprisingly, apparent digoxin concentrations were falsely lowered when MEIA was used. Digibind neutralizes free apparent digoxin concentration in vitro in serum pools supplemented with oleander extract, and this effect can be measured by the FPIA. We conclude that FPIA is most sensitive to detect the presence of oleander in serum. In contrast, the CLIA (no cross-reactivity) should be used for monitoring digoxin in a patient receiving digoxin and self-medicated with a herbal remedy containing oleander. PMID:15570191

Dasgupta, Amitava; Datta, Pradip

2004-12-01

60

Rapid detection of oleander poisoning by Digoxin III, a new Digoxin assay: impact on serum Digoxin measurement.  

PubMed

We studied the potential for detecting oleander with a new immunoassay (Digoxin III, Abbott Laboratories, Abbott Park, IL) by comparing results with those from the fluorescence polarization immunoassay (FPIA) and Digoxin II assay (Abbott). In aliquots of drug-free serum pools supplemented with pure oleandrin or oleander extract, we observed apparent digoxin values using all 3 immunoassays, but values obtained by the Digoxin III were higher than obtained by the other assays. We also observed significant apparent digoxin values in vivo in serum samples of mice 1 and 2 hours after feeding oleander extract. The average half-life of digoxin-like factors was 1.1 hours. In a serum pool (prepared from patients taking digoxin) supplemented with oleander extract, the observed digoxin values were falsely lowered when measured by the Digoxin II but falsely elevated when measured by the Digoxin III and FPIA. Monitoring free digoxin using the Digoxin III cannot eliminate this interference. Digibind neutralized digoxin-like factors of oleander extract; the effect can be monitored by observing a significant reduction in apparent free digoxin levels in the presence of Digibind as measured in protein-free ultrafiltrate using the Digoxin III. The Digoxin III is highly sensitive for measuring oleander. PMID:18343781

Dasgupta, Amitava; Risin, Semyon A; Reyes, Meredith; Actor, Jeffrey K

2008-04-01

61

Alterations in blood electrolytes of a freshwater catfish Heteropneustes fossilis in response to treatment with a botanical pesticide, Nerium indicum leaf extract.  

PubMed

The present study aimed at investigating the effects of Nerium indicum leaf extract on the blood electrolytes of Heteropneustes fossilis for short- and long term. Fish were subjected to Nerium indicum leaf extract for short term (11.27 mg/L i.e. 0.8 of 96 h LC??) and long term (2.81 mg/L i.e. 0.2 of 96 h LC??). Fish were killed on each time intervals from control and experimental (Nerium indicum) groups after 24, 48, 72, and 96 h in short-term exposure and after 7, 14, 21, and 28 days in long-term experiment. Blood samples were analyzed for calcium and inorganic phosphate levels. Acute exposure of Nerium indicum leaf extract caused a progressive decrease in the serum calcium levels after 48 h in fish H. fossilis, which persists till the close of the experiment (96 h). The serum inorganic phosphate levels remain unaffected till 48 h in the Nerium indicum leaf extract-exposed fish. After 72 and 96 h, the levels exhibit a decrease. Chronic Nerium indicum leaf extract treatment provoked a decrease in serum calcium levels at day 14. This decrease continues till 28 days. The serum phosphate level of the Nerium indicum leaf extract-treated fish decreases on day 14 and 21. However, on day 28, the levels become close to the normal values. We conclude that Nerium indicum leaf extract exposure alters the blood electrolytes of the fish, thus causing physiological disturbances which might affect seriously the normal vital functions, growth rate, reproduction, and their survival in nature. PMID:21127966

Prasad, Maniram; Kumar, Abhishek; Mishra, Diwakar; Srivastav, Sunil K; Srivastav, Ajai K

2011-09-01

62

Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity  

Microsoft Academic Search

Cardiac glycosides from fresh leaves of Nerium indicum were evaluated for its molluscicidal activity against Pomacea canaliculata (golden apple snail: GAS) under laboratory conditions. The results showed that LC50 value of cardiac glycosides against GAS was time dependent and the LC50 value at 96h was as low as 3.71mg\\/L, which was comparable with that of metaldehyde at 72h (3.88mg\\/L). These

Lingpeng Dai; Wanxian Wang; Xinjiao Dong; Renyong Hu; Xuyang Nan

2011-01-01

63

Eating seeds from the 'be still' tree, yet having lucky nut poisoning: a case of acute yellow oleander poisoning.  

PubMed

A 25-year-old woman was evaluated and treated for ingestion of Thevetia peruviana seeds and flower petals-a natural digoxin cross reacting cardinolide-with intent to cause self-harm. The following case report provides the clinical presentation, treatment and management of acute yellow oleander poisoning. PMID:24898992

Fentanes, Emilio

2014-01-01

64

A TaqMan-based real time PCR assay for specific detection and quantification of Xylella fastidiosa strains causing bacterial leaf scorch in oleander.  

PubMed

A TaqMan-based real-time PCR assay was developed for specific detection of strains of X. fastidiosa causing oleander leaf scorch. The assay uses primers WG-OLS-F1 and WG-OLS-R1 and the fluorescent probe WG-OLS-P1, designed based on unique sequences found only in the genome of oleander strain Ann1. The assay is specific, allowing detection of only oleander-infecting strains, not other strains of X. fastidiosa nor other plant-associated bacteria tested. The assay is also sensitive, with a detection limit of 10.4fg DNA of X. fastidiosa per reaction in vitro and in planta. The assay can also be applied to detect low numbers of X. fastidiosa in insect samples, or further developed into a multiplex real-time PCR assay to simultaneously detect and distinguish diverse strains of X. fastidiosa that may occupy the same hosts or insect vectors. Specific and sensitive detection and quantification of oleander strains of X. fastidiosa should be useful for disease diagnosis, epidemiological studies, management of oleander leaf scorch disease, and resistance screening for oleander shrubs. PMID:23165115

Guan, Wei; Shao, Jonathan; Singh, Raghuwinder; Davis, Robert E; Zhao, Tingchang; Huang, Qi

2013-02-15

65

Pontibacter rhizosphera sp. nov., isolated from rhizosphere soil of an Indian medicinal plant Nerium indicum.  

PubMed

A gram-negative, motile, straight to curved rod shaped, pink pigmented bacterium was isolated from a soil sample collected from the rhizosphere of an Indian medicinal plant, Nerium indicum (Chuvanna arali) and subjected to a detailed polyphasic taxonomic study. The strain, designated as IMTB-1969(T), matched with most of the phenotypic and chemotaxonomic properties of the genus Pontibacter and represents a novel species. The major fatty acids of the strain were monounsaturated iso/anteiso branched C17 fatty acids (45.1%) and iso-C15:0 (16.5%). MK-7 was the predominant isoprenoid quinone. According to 16S rRNA gene sequence analysis, strain IMTB-1969(T) was indicated to belonged to the phylum Bacteroidetes and further phylogenetic analysis revealed that the strain IMTB-1969(T) belongs to the family Cytophagaceae and genus Pontibacter. The highest 16S rRNA gene sequence similarity was with Pontibacter korlensis CCTCC AB 206081(T) (97.2%) and lower sequence similarity was observed with other species in the genus Pontibacter (95.9-94.0%). DNA-DNA relatedness study of the strain IMTB-1969(T) confirmed that it represents a novel species. The G+C content of the genomic DNA was 52.2 (±0.5) mol%. The results of physiological and biochemical tests allowed the genotypic and phenotypic distinction of strain IMTB-1969(T) from its closest phylogenetic relatives. The strain IMTB-1969(T) should be classified as novel species of the genus Pontibacter, for which the name Pontibacter rhizosphera sp. nov. is proposed. The type strain is IMTB-1969(T) (=MTCC 10673(T) = DSM 24399(T)). PMID:21409554

Raichand, Revti; Kaur, Ishwinder; Singh, Nitin Kumar; Mayilraj, Shanmugam

2011-06-01

66

Mapping Gulf Stream warm core rings from shipboard ADCP transects of the Oleander Project  

NASA Astrophysics Data System (ADS)

The flow patterns of the Gulf Stream warm core rings and surrounding shelf break and slope water are constructed from shipboard acoustic Doppler current profiler (ADCP) transects of the Oleander Project. For each warm ring, consecutive ADCP transects are colocated to a common ring center and are mapped into a stream function. Methods to locate ring centers from the ADCP transect and advanced very high resolution radiometer image are developed and tested. Two warm rings in 1999, which have relatively complete data coverage, are examined to study the ring-induced warm and cold streamers. For cold streamers, the estimated volume flux, based on more than 10 independent ADCP transects, is at least 1 × 106 m3 s-1. This result agrees well with the previous estimate in the Warm Core Ring Experiment. For warm streamers, the result is new. On the basis of a large number of ADCP transects, the estimated volume flux is about 2.5 × 106 m3 s-1. By pulling large transports associated with the cold/warm streamers, the warm rings likely play a fundamental role in the water exchange in the Slope Sea.

Wei, Jun; Wang, Dong-Ping; Flagg, Charles N.

2008-10-01

67

Rapid detection of oleander poisoning using fluorescence polarization immunoassay for digitoxin. Effect of treatment with digoxin-specific Fab antibody fragment (ovine).  

PubMed

Poisoning from the oleander plant is common. Taking advantage of the high cross-reactivity of oleandrin, the major cardiac glycoside found in the oleander plant, we demonstrated that the serum digitoxin assay can be successfully used for the rapid diagnosis of oleander poisoning. Digitoxin is rarely used for treatment of cardiac disorders in the United States and has a therapeutic range of 19.7 to 39.3 nmol/L. In a typical oleander poisoning, serum oleandrin concentrations may reach 174 mmol/L or more. A serum specimen supplemented with 174 mmol/L of oleandrin containing no digitoxin showed an apparent digitoxin concentration of 1,272.1 nmol/L, a very high value compared with the range of the serum digitoxin assay, which is 2.6 to 104.8 nmol/L. Moreover, the response of the serum digitoxin assay with serum specimens containing various concentrations of oleandrin (and no digitoxin) is linear. Therefore, the oleandrin concentration in serum can be calculated from the apparent digitoxin concentration to access the severity of poisoning. Recently, the usefulness of the digoxin-specific Fab antibody fragment in the treatment of oleander poisoning has been described; however, no laboratory test was performed to demonstrate the progress of therapy. We demonstrated that the digoxin-specific Fab antibody can bind oleandrin in vitro, thus reducing the pharmacologically active free oleandrin. Because Fab and oleandrin bound to Fab are absent in the protein-free ultrafiltrates, monitoring the activity of free oleandrin in the ultrafiltrates can be used for monitoring the effectiveness of therapy. PMID:9322594

Dasgupta, A; Hart, A P

1997-10-01

68

The Oleander Program - 9 years of Gulf Stream Sampling and Still Going Strong!  

NASA Astrophysics Data System (ADS)

Starting in Fall 1992 we have been monitoring the currents between the mid-Atlantic Bight and the NW Sargasso Sea with an acoustic Doppler current profiler on the freighter CMV Oleander, which makes weekly roundtrips between Port Elizabeth, NJ and Bermuda. In addition, XBTs and surface salts have been taken on a monthly basis since 1979. These systematic observations of the upper ocean are giving us new insights into the structure of the Gulf Stream and adjacent waters. In this overview we will highlight some of the major findings of this ongoing program. One of the more striking observations is perhaps the structural stability of the Gulf Stream itself. Its shape can be characterized as a double-exponential which results from the mixing or homogenization of waters between the current and either side, but not across it. We show that 80 percent of the Eulerian eddy kinetic energy that is observed in the Gulf Stream can be described in terms of the meandering of a rigid double-exponential current. The remaining variability can be accounted for in terms of a few structural modes that are most likely associated with the meandering of the current. We have found that the transport of the current has been conspicuously stable, and will argue that past thoughts about large variations in transport may result from an inability to distinguish between the current itself and adjacent local recirculations of varying intensity. The distinction is made clear thanks to the repeat sampling. However, the Gulf Stream does exhibit significant variations in mean path on interannual time scales. These show a strong correlation with temperature-salinity anomalies in the Slope Sea. We suggest that both result from time-varying transports from the Labrador shelf, but there is presently considerable discussion as to whether the path shifting should be viewed as a thermohaline or a winddriven process. More generally, we use the above examples to argue that with more deliberate planning, the unparalleled and repeat access to in-situ sampling of the oceans provided by commercial shipping and cruise vessels could provide society with far more extensive and valuable information about the ocean and atmospheric conditions at sea. But for this to happen, the instrumentation needs to be optimized for completely automatic and unattended operation. This also means working with the merchant marine community to develop guidelines and procedures for future cooperative efforts.

Rossby, T.

2001-12-01

69

Sex pheromone of the oleander scale, Aspidiotus nerii: Structural characterization and absolute configuration of an unusual functionalized cyclobutane  

PubMed Central

The sex pheromone emitted by the female oleander scale, Aspidiotus nerii (Homoptera, Diaspididae), has been isolated and characterized as (1R,2S)-cis-2-isopropenyl-1-(4?-methyl-4?-penten-1?-yl)cyclobutaneethanol acetate by using advanced MS and NMR spectroscopic methods, as well as a variety of microderivatization sequences. The structure has been confirmed by stereo- and enantioselective synthesis of the four possible stereoisomers. The absolute configuration has been determined by comparison of the activity of the cis (1S,2R) and (1R,2S) enantiomers with that exhibited by the natural material in greenhouse bioassays and field tests. The structure of this sesquiterpenoid pheromone is new in the coccids and in the pheromone field in general.

Einhorn, Jacques; Guerrero, Angel; Ducrot, Paul-Henri; Boyer, Francois-Didier; Gieselmann, Mary; Roelofs, Wendell

1998-01-01

70

Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity.  

PubMed

Cardiac glycosides from fresh leaves of Nerium indicum were evaluated for its molluscicidal activity against Pomacea canaliculata (golden apple snail: GAS) under laboratory conditions. The results showed that LC(50) value of cardiac glycosides against GAS was time dependent and the LC(50) value at 96 h was as low as 3.71 mg/L, which was comparable with that of metaldehyde at 72 h (3.88 mg/L). These results indicate that cardiac glycosides could be an effective molluscicide against GAS. The toxicological mechanism of cardiac glucosides on GAS was also evaluated through changes of selected biochemical parameters, including cholinesterase (ChE) and esterase (EST) activities, glycogen and protein contents in hepatopancreas tissues of GAS. Exposure to sublethal concentrations of cardiac glycosides, GAS showed lower activities of EST isozyme in the later stages of the exposure period as well as drastically decreased glycogen content, although total protein content was not affected at the end of 24 and 48 h followed by a significant depletion at the end of 72 and 96 h. The initial increase followed by a decline of ChE activity was also observed during the experiment. These results suggest that cardiac glycosides seriously impair normal physiological metabolism, resulting in fatal alterations in major biochemical constituents of hepatopancreas tissues of P. canaliculata. PMID:21843803

Dai, Lingpeng; Wang, Wanxian; Dong, Xinjiao; Hu, Renyong; Nan, Xuyang

2011-09-01

71

Multilocus sequence typing of Xylella fastidiosa causing Pierce's disease and oleander leaf scorch in the United States.  

PubMed

Using a modified multilocus sequence typing (MLST) scheme for the bacterial plant pathogen Xylella fastidiosa based on the same seven housekeeping genes employed in a previously published MLST, we studied the genetic diversity of two subspecies, X. fastidiosa subsp. fastidiosa and X. fastidiosa subsp. sandyi, which cause Pierce's disease and oleander leaf scorch, respectively. Typing of 85 U.S. isolates (plus one from northern Mexico) of X. fastidiosa subsp. fastidiosa from 15 different plant hosts and 21 isolates of X. fastidiosa subsp. sandyi from 4 different hosts in California and Texas supported their subspecific status. Analysis using the MLST genes plus one cell-surface gene showed no significant genetic differentiation based on geography or host plant within either subspecies. Two cases of homologous recombination (with X. fastidiosa subsp. multiplex, the third U.S. subspecies) were detected in X. fastidiosa subsp. fastidiosa. Excluding recombination, MLST site polymorphism in X. fastidiosa subsp. fastidiosa (0.048%) and X. fastidiosa subsp. sandyi (0.000%) was substantially lower than in X. fastidiosa subsp. multiplex (0.240%), consistent with the hypothesis that X. fastidiosa subspp. fastidiosa and sandyi were introduced into the United States (probably just prior to 1880 and 1980, respectively). Using whole-genome analysis, we showed that MLST is more effective at genetic discrimination at the specific and subspecific level than other typing methods applied to X. fastidiosa. Moreover, MLST is the only technique effective in detecting recombination. PMID:20465416

Yuan, Xiaoli; Morano, Lisa; Bromley, Robin; Spring-Pearson, Senanu; Stouthamer, Richard; Nunney, Leonard

2010-06-01

72

A case of nondigitalis cardiac glycoside toxicity.  

PubMed

A case is presented of cardiac glycoside poisoning in a 1-year-old patient from the plant Nerium oleander (common oleander). The patient had bradycardia, vomiting, altered level of consciousness, and no history of ingestion. Antibody-based digoxin assays may cross-react with other cardiac glycosides nonquantitatively. Chromatographic techniques can be used in the specific diagnosis. PMID:9421116

Gupta, A; Joshi, P; Jortani, S A; Valdes, R; Thorkelsson, T; Verjee, Z; Shemie, S

1997-12-01

73

Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow Oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal.  

PubMed

Intentional self-poisonings with seeds from the yellow oleander tree (Thevetia peruviana) are widely reported. Activated charcoal has been suggested to benefit patients with yellow oleander poisoning by reducing absorption and/or facilitating elimination. Two recent randomized controlled trials (RCTs) assessing the efficacy of activated charcoal yielded conflicting outcomes in terms of mortality. The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been assessed. This information may be useful for determining whether further studies are necessary. Serial blood samples were obtained from patients enrolled in an RCT assessing the relative efficacy of single-dose and multiple-dose activated charcoal (SDAC and MDAC, respectively) compared with no activated charcoal (NoAC). The concentration of Thevetia cardenolides was estimated with a digoxin immunoassay. The effect of activated charcoal on cardenolide pharmacokinetics was compared between treatment groups by determining the area under the curve for each patient in the 24 hours following admission, the 24-hour mean residence time, and regression lines obtained from serial concentration points, adjusted for exposure. Erratic and prolonged absorption patterns were noted in each patient group. The apparent terminal half-life was highly variable, with a median time of 42.9 hours. There was a reduction in 24-hour mean residence time and in the apparent terminal half-life estimated from linear regression in patients administered activated charcoal, versus the control group (NoAC). This effect was approximately equal in patients administered MDAC or SDAC. Activated charcoal appears to favorably influence the pharmacokinetic profile of Thevetia cardenolides in patients with acute self-poisoning and may have clinical benefits. Given the conflicting clinical outcomes noted in previous RCTs, these mechanistic data support the need for further studies to determine whether a particular subgroup of patients (eg, those presenting soon after poisoning) will benefit from activated charcoal. PMID:17164695

Roberts, Darren M; Southcott, Emma; Potter, Julia M; Roberts, Michael S; Eddleston, Michael; Buckley, Nick A

2006-12-01

74

Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal.  

PubMed Central

Intentional self-poisonings with seeds from the yellow oleander tree (Thevetia peruviana) are widely reported. Activated charcoal has been suggested to benefit patients with yellow oleander poisoning by reducing absorption and/or facilitating elimination. Two recent randomised controlled trials (RCTs) assessing the efficacy of activated charcoal reported conflicting outcomes in terms of mortality. The effect of activated charcoal on the pharmacokinetics of Thevetia cardenolides has not been assessed. This information may be useful for determining whether further studies are necessary. Serial blood samples were obtained from patients enrolled in a RCT assessing the relative efficacy of single dose (SDAC) and multiple doses (MDAC) of activated charcoal compared to no activated charcoal (NoAC). The concentration of Thevetia cardenolides was estimated using a digoxin immunoassay. The effect of activated charcoal on cardenolide pharmacokinetics was compared between treatment groups using the AUC24, the 24h Mean Residence Time (MRT24), and regression lines obtained from serial concentration points adjusted for exposure. Erratic and prolonged absorption patterns were noted in each patient group. The apparent terminal half-life was highly variable, with a median time of 42.9h. There was a reduction in MRT24 and the apparent terminal half-life estimated from linear regression in patients administered activated charcoal compared to the control group (NoAC). This effect was approximately equal in patients administered MDAC or SDAC. Activated charcoal appears to favourably influence the pharmacokinetic profile of Thevetia cardenolides in patients with acute self-poisoning, which may have clinical benefits. Given the conflicting clinical outcomes noted in previous RCTs, this mechanistic data supports the need for further studies to determine whether a subgroup of patients (eg. those presenting soon after poisoning) will benefit from activated charcoal.

Roberts, Darren M; Southcott, Emma; Potter, Julia M; Roberts, Michael S; Eddleston, Michael; Buckley, Nick A

2008-01-01

75

Effect of cardiac glycosides from Nerium indicum on feeding rate, digestive enzymes activity and ultrastructural alterations of hepatopancreas in Pomacea canaliculata.  

PubMed

Cardiac glycosides from Nerium indicum showed potent molluscicide activity against Pomacea canaliculata (GAS), but the toxicological mechanism is still far less understood. Effects of sublethal treatments of cardiac glycosides on feeding rate, digestive enzymes and ultrastructural alterations of the hepatopancreas in GAS were evaluated in this study. Exposure of GAS to sublethal concentrations of cardiac glycosides resulted in a significant reduction of feeding rate of GAS. The amylase, cellulose and protease activity were increase significantly at the end of 24 h followed by significant inhibition after 48 h of exposure while lipase activity was not affected significantly at the end of 24 h followed by a significant inhibition after 48 h of exposure during experimental period. The main ultrastructural alterations of hepatopancreas observed in snails under cardiac glycosides treatment comprised disruption of nuclear membrane, increased vesiculation and dilatation of endoplasmic reticulum, and vacuolization and swelling of mitochondrial compared to the untreated GAS. These results, for the first time, provide systematic evidences showing that cardiac glycosides seriously impairs the hepatopancreas tissues of GAS, resulting in inhibition of digestive enzymes activity and feeding rate and cause GAS death in the end. PMID:24361644

Dai, Lingpeng; Qian, Xiaowei; Nan, Xuyang; Zhang, Yejian

2014-01-01

76

From the CMV Oleander Project: A Study of the Shelfbreak Front of the Middle Atlantic Bight From Long-term ADCP and Hydrographic Data  

NASA Astrophysics Data System (ADS)

Utilizing the first decade of shipboard ADCP data as well as XBT and surface salinity data obtained from the CMV Oleander, this study is focused on the mean structure, and seasonal and interannual variability of the frontal zone at the edge of the shelf of the Middle Atlantic Bight. The early analysis showed that more than half the data in the frontal zone were influenced by warm core rings and that removing the confounding influence of the rings was vital if the true structure of the front was to emerge. From the culled data set of 128 transects of the front with sufficient coverage we have proceeded to generate a velocity description following the core of the frontal jet showing a maximum, surface intensified velocity of more than 0.25 ms-1, a vertical extent of roughly 80 m, a half-amplitude width of about 20 km and an alongshore transport of ~0.34 Sv. The maximum mean relative vorticity of the jet is 0.56*f. The alongshore jet is accompanied by a substantial surface intensified convergent flow that implies a maximum down-welling in the center of the jet of ~30 m/day. The seasonally the shelfbreak jet has its minimal velocities during the summer months, increasing to maximal velocities during the winter before decreasing agin in the spring. An interesting feature that emerges from the ADCP data is that while the shelfbreak frontal jet is usually assumed to consist of a single high-speed core, in fact, the jet often exhibits multiple high velocity extrema, the existence of which appears to undergo a seasonal progression.

Flagg, C. N.; Dunn, M.; Wang, D.

2004-12-01

77

A study of air pollution with heavy metals in Thessaloniki city (Greece) using trees as biological indicators  

Microsoft Academic Search

The air pollution of the city of Thessaloniki was studied, using park trees as biomonitors. The species analyzed were Ligustrum japonicum, Nerium oleander, Olea europea, Pinus brutia, Platanus orientalis, Populus alba, Populus nigra, and Robinia pseudoacacia. Acid digestion of leaf tissues and subsequent use of atomic absorption spectrometry was the analytical methodology used for the determination of heavy metals (Cu,

T. Sawidis; A. Marnasidis; G. Zachariadis; J. Stratis

1995-01-01

78

Genetic Differentiation in Tetranychus Urticae (Acari: Tetranychidae): polymorphism, host races or sibling species?  

Microsoft Academic Search

Based on allozyme electrophoresis at the Pgm locus and nuclear ribosomal DNA (ITS2) sequences, we studied the genetic variation of the two-spotted spider mite Tetranychus urticae Koch collected on rose bay, Nerium oleander L. (Apocynaceae), from several localities around the Mediterranean basin. In addition, we compared these results with those of Navajas et al. (1998) and Tsagkarakou (1997) who collected

Maria Navajas; Anastasia Tsagkarakov; Jaques Lagnel; Marie-Jeanne Perrot-Minnot

2000-01-01

79

Inhibition of photosynthetic reactions under water stress: interaction with light level  

Microsoft Academic Search

When the shrub Nerium oleander L., growing under full natural daylight outdoors, was subjected to water stress, stomatal conductance declined, and so did non-stomatal components of photosynthesis, including the CO2-saturated rate of CO2 uptake by intact leaves and the activity of electron transport by chloroplasts isolated from stressed plants. This inactivation of photosynthetic activity was accompanied by changes in the

Olle Björkman; Stephen B. Powles

1984-01-01

80

Fire retardancy impact of sodium bicarbonate on ligno-cellulosic materials  

Microsoft Academic Search

In this paper, the effect of NaHCO3 as fire retardant additive during pyrolysis and combustion has been investigated. Four different contents (5%, 10%, 15%, and 20% w\\/w) of NaHCO3 have been tested on Pinus brutia, Laurus nobilis and Nerium oleander; forest species commonly dispersed in the Mediterranean region. Pyrolysis experiments have been conducted using a thermogravimetric analyzer (TGA) employing nitrogen

D. Bakirtzis; M. A. Delichatsios; S. Liodakis; W. Ahmed

2009-01-01

81

Análisis descriptivo del tamaño relativo del gasto del gobierno chileno  

Microsoft Academic Search

En este trabajo se examina el tamaño relativo del Gobierno chileno a través de una comparación internacional con valores equivalentes de otros países. Adicionalmente hay un análisis similar para dos componentes importantes del gasto público: educación y salud. El gasto del Gobierno de Chile, valor en torno del 20% (PIB), está junto al tercio inferior de países que poseen un

Eduardo Engel; Patricio Meller; Claudio Bravo

1998-01-01

82

Atlas del Genoma del Cáncer  

Cancer.gov

Es posible que haya más de 200 tipos diferentes de cáncer y muchos subtipos más, cada uno de estos causado por errores en el ADN que desencadenan el crecimiento descontrolado de las células. La identificación de los cambios en el conjunto completo de ADN de cada tipo de cáncer, su genoma, y el entendimiento de cómo interactúan dichos cambios para impulsar el proceso de la enfermedad sentarán las bases de una era individualizada de tratamiento del cáncer.

83

Instantánea del cáncer infantil  

Cancer.gov

Información sobre la incidencia y mortalidad del cáncer en los niños, tendencias en el financiamiento del NCI para la investigación del cáncer infantil; así como ejemplos de actividades y adelantos en la investigación relevantes para esta población.

84

Políticas del sitio web  

Cancer.gov

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.

85

Instantánea del cáncer colorrectal  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

86

Impact des produits de lessivage de feuilles mortes sur la teneur en oxygène de l'eau et sur la survie d'un gastéropode  

NASA Astrophysics Data System (ADS)

The impact of the leaching of oleander, Nerium oleander, and willow, Salix pedicellata, leaves on the aquatic environment was investigated in the laboratory. The leaves were collected on the banks of a Moroccan stream, leachate polyphenols were analysed, and leachate toxic effects on the dominant gastropod species of the stream were investigated. The following factors were considered: leaf species, dry or fresh state of the leaves, litter concentration, duration of leaching, temperature. Within the first 8-12 hrs of submersion, the litter of both species caused a great depletion of dissolved oxygen. Later, oxygen consumption decreased. Dry oleander leaves caused a greater drop in oxygen concentration than fresh oleander leaves. The opposite was observed in willow leaves, most clearly at 5 and 10°C. At higher temperatures (20 and 25°C), oxygen nearly totally disappeared under all conditions, leaving 0 to 2 mg.I -1 after 48 hours. Whether fresh or dry, oleander leaves always caused a greater oxygen depletion than willow leaves. Willow leaves contained more tannin-and non-tannin-polyphenols than oleander leaves, and their leaching released more of these compounds, especially in dry leaves. The leaching of both leaf species only had a toxic effect on the gastropods at the higher temperatures (20 and 25°C), thus suggesting that the toxic effect was mainly due to lack of oxygen in the water. At these temperatures, the toxic effect of dry leaves was greater than that of fresh leaves. Oleander proved more toxic than willow, presumably under the influence of both lack of oxygen and toxic heterosides.

Chergui, H.; Haddy, L.; Markaoui, M.; Pattee, E.

87

Boletín del Instituto Nacional del Cáncer - 16 de enero 2013  

Cancer.gov

El Boletín del Instituto Nacional del Cáncer ha suspendido su publicación a partir del 16 de enero de 2013. El archivo del Boletín, que cuenta con todas las ediciones publicadas desde 2009 a 2013, permanecerá a disposición de los lectores en el sitio web del NCI.

88

La teoria del pendolo  

Microsoft Academic Search

Il silenzio era tale che, ascoltando attentamente, si sarebbe potuto udire la voce dell'anima. Era proprio questo il motivo per cui Galileo si alzava ogni mattina di buon ora per dire le sue orazioni innanzi al maestoso altare del duomo. Guardava a lungo le volte intorno a lui cercando con lo sguardo la perfezione del creato e poi, con l'ambiguità

Di Claudio Chillemi

89

Comparison of the suitability of two lichen species and one higher plant for monitoring airborne heavy metals.  

PubMed

We compared the capacity to accumulate airborne heavy metals of two lichens (Flavoparmelia caperata and Parmotrema chinense) and one higher plant (Nerium oleander) at a very densely populated urban site near Naples. After 15, 45, 75, and 120 days of exposure at four sites with different levels of air pollution, equal portions of thalli and 20 leaves were collected, and four environmentally significant elements, Fe, Cu, Zn, and Pb, were measured by inductively coupled plasma analysis. To compare the accumulation rates of lichens and the vascular plant, we determined an index of relative accumulation rate of pollutants during time and the ratio between the concentrations of each element in exposed samples to that of control samples (exposed-to-control ratio). Our data indicate F. caperata as being the most suitable bioaccumulator, followed by P. chinense. N. oleander was also found to be a useful heavy metal biomonitor though not suitable as a bioaccumulator. PMID:19255863

Aprile, Giuseppa Grazia; Di Salvatore, Mina; Carratù, Giovanna; Mingo, Antonio; Carafa, Anna Maria

2010-03-01

90

Evaluación del desempeño integral del sector transporte  

Microsoft Academic Search

Las organizaciones hoy por hoy buscan aplicar un sistema de indicadores que evalúe la gestión y el desempeño del sector transporte en materia económica, social, ambiental e integral, con el fin de garantizar a las partes interesadas una información confiable sobre los resultados de desempeño frente al desarrollo sostenible, que facilite el ingreso a mercados nacionales e internacionales a partir

Clara Inés Pardo Martínez

2007-01-01

91

Naturally occurring cardiac glycosides.  

PubMed

Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. Significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (Thevetia peruviana); oleander (Nerium oleander); wintersweet (Carissa spectabilis); bushman's poison (Carissa acokanthera); sea-mango (Cerbera manghas); and frangipani (Plumeria rubra); and in the milkweeds: redheaded cotton-bush (Asclepias curassavica); balloon cotton (Asclepias fruiticosa); king's crown (Calotropis procera); and rubber vine (Cryptostegia grandifolia). The venom gland of the cane toad (Bufo marinus) also contained large quantities of cardiac glycosides. The competitive immunoassay method permits the rapid screening of specimens that are suspected to contain cardiac glycosides. Awareness of the existence of these plant and animal toxins and their dangers allows them to be avoided and poisoning prevented. The method is also useful for the confirmation of the presence of cardiac glycosides in serum in cases of poisoning. PMID:3086679

Radford, D J; Gillies, A D; Hinds, J A; Duffy, P

1986-05-12

92

Determination of oleandrin in tissues and biological fluids by liquid chromatography-electrospray tandem mass spectrometry.  

PubMed

A rapid LC-MS/MS method, using a triple-quadrupole/linear ion trap mass spectrometer, was developed for the quantitative determination of oleandrin in serum, urine, and tissue samples. Oleandrin, the major cardiac glycoside of oleander (Nerium oleander L.), was extracted from serum and urine samples with methylene chloride and from tissues with acetonitrile. The tissue extracts were cleaned up using Florisil solid-phase extraction columns. Six replicate fortifications of serum and urine at 0.001 microg/g (1 ppb) oleandrin gave average recoveries of 97% with 5% CV (relative standard deviation) and 107% with 7% CV, respectively. Six replicate fortifications of liver at 0.005 microg/g (5 ppb) oleandrin gave average recoveries of 98% with 6% CV. This is the first report of a positive mass spectrometric identification and quantitation of oleandrin in tissue samples from oleander intoxication cases. The sensitivity and specificity of the LC-MS/MS analysis enables it to be the method of choice for toxicological investigations of oleander poisoning. PMID:15913289

Tor, Elizabeth R; Filigenzi, Michael S; Puschner, Birgit

2005-06-01

93

Boletín del Instituto Nacional del Cáncer - 07-20-2010  

Cancer.gov

El doctor Harold Varmus, acompañado de su esposa Constance Casey (centro), presta juramento como director del NCI ante la Secretaria del Departamento de Salud y Servicios Humanos, Kathleen Sebelius, el lunes 12 de julio. (Foto cortesía de Chris Smith) El 12 de julio, el doctor Harold Varmus prestó juramento ante la Secretaria del Departamento de Salud y Servicios Humanos de los Estados Unidos, Kathleen Sebelios, como el decimocuarto director del Instituto Nacional del Cáncer.

94

Hojas informativas del NCI  

Cancer.gov

La colección de hojas informativas del NCI trata de una variedad de temas relacionados con el cáncer. Las hojas informativas se revisan y ponen al día de acuerdo a las investigaciones más recientes sobre el cáncer.

95

Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

D'Antona, F.

1995-03-01

96

Amenazas comerciales del Acuerdo Can-Mercosur para los sectores productivos del Valle del Cauca  

Microsoft Academic Search

El Acuerdo de Complementación Económica, suscrito entre la Comunidad Andina (CAN) y el Mercado Común del Sur (MERCOSUR), marca un avance hacia una integración económica y política más profunda en América Latina. Por tal razón, el objetivo del presente artículo es identificar los sectores del Valle del Cauca que revelan desventajas competitivas relativas, por lo que se pueden ver potencialmente

Lya Paola Sierra Suárez; José Tomás Peláez Soto

2008-01-01

97

EL DESARROLLO DEL PENSAMIENTO CRÍTICO DEL ESTUDIANTE. UNA FINALIDAD EDUCATIVA PENDIENTE DEL ÁREA CURRICULAR ESTUDIOS SOCIALES  

Microsoft Academic Search

Esta investigación tuvo como objetivo determinar las características del proceso instruccional en la tercera etapa del nivel de Educación Básica que contribuyen al desarrollo del pensamiento crítico del estudiante para satisfacer el imperativo legal vigente desde julio de 1980, particularmente para el área curricular Estudios Sociales. Durante cuatro años escolares en dos instituciones educativas que ofrecen el precitado nivel se

Haydée Páez

98

Espectroscopia del Cometa Halley  

NASA Astrophysics Data System (ADS)

Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.

1987-05-01

99

Boletín del Instituto Nacional del Cáncer  

Cancer.gov

No se puede negar que vivimos en una comunidad global, en la que los eventos de una ciudad o país pueden tener graves consecuencias para los residentes de otra ciudad o país a miles de kilómetros de distancia. Ya sea la pandemia del virus H1N1, los recientes disturbios en Irán o la recesión económica mundial, es evidente que esta interconectividad trae consigo retos importantes. Pero también puede crear oportunidades sin precedentes, en particular aquellas que podrían mejorar sustancialmente la salud pública.

100

Pruebas de Papanicolaou y del virus del papiloma humano (VPH)  

Cancer.gov

Hoja informativa que describe los exámenes selectivos de detección del cáncer de cérvix, los cuales incluyen la prueba de Papanicolaou y la prueba de los virus del papiloma humano. La hoja informativa incluye también información acerca de las pautas de exámenes de detección del cáncer de cérvix.

101

Instantánea del cáncer de esófago  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

102

Instantánea del cáncer de próstata  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

103

Instantánea del cáncer de estómago  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

104

Instantánea del sarcoma de Kaposi  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

105

Instantánea del cáncer de tiroides  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

106

Instantánea del cáncer de ovario  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

107

Instantánea del cáncer de endometrio  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

108

Instantánea del cáncer de vejiga  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

109

Instantánea del cáncer de riñón  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

110

Instantánea del cáncer de páncreas  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

111

Instantánea del cáncer de pulmón  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

112

Unripe red fruits may be aposematic.  

PubMed

The unripe fruits of certain species are red. Some of these species disperse their seeds by wind (Nerium oleander, Anabasis articulata), others by adhering to animals with their spines (Emex spinosa) or prickles (Hedysarum spinosissimum). Certainly neither type uses red coloration as advertisement to attract the seed dispersing agents. Fleshy-fruited species (Rhamnus alaternus, Rubus sanguineus and Pistacia sp.), which disperse their seeds via frugivores, change fruit color from green to red while still unripe and then to black or dark blue upon ripening. The red color does not seem to function primarily in dispersal (unless red fruits form advertisement flags when there are already black ripe fruits on the plant) because the red unripe fruits of these species are poisonous, spiny, or unpalatable. The unripe red fruits of Nerium oleander are very poisonous, those of Rhamnus alaternus and Anabasis articulata are moderately poisonous, those of Rubus sanguineus are very sour, those of Pistacia sp. contain unpalatable resin and those of Emex spinosa and Hedysarum spinosissimum are prickly. We propose that these unripe red fruits are aposematic, protecting them from herbivory before seed maturation. PMID:19847110

Lev-Yadun, Simcha; Ne'eman, Gidi; Izhaki, Ido

2009-09-01

113

Flammability of some ornamental species in wildland-urban interfaces in southeastern France: laboratory assessment at particle level.  

PubMed

Assessment of the flammability of ornamental vegetation (particularly hedges) planted around houses is necessary in light of the increasing urbanization of the wildland-urban interfaces (WUIs) and the high fire occurrence in such areas. The structure and flammability of seven of the species most frequently planted as hedges in Provence (southeastern France) were studied at particle level. Spatial repartition of the different types of fuel particles within plants was assessed by means of the cube method. The leaf flammability was assessed using an epiradiator as a burning device, and measurements of foliar physical characteristics and gross heat of combustion (GHC) helped to explain the results of burning experiments. Co-inertia analysis revealed that species with thin leaves were quick to ignite (Pyracantha coccinea, Phyllostachys sp.) and species with high leaf GHC burned the longest (Pittosporum tobira, Nerium oleander). Species presenting high ignitability (Photinia fraseri, Phyllostachys sp. and Pyracantha coccinea) were characterized by high foliar surface area-to-volume ratio, and species presenting lower ignitability were characterized by high GHC (Pittosporum tobira, Nerium oleander, Cupressus sempervirens). Hierarchical cluster analysis of the flammability variables (ignition frequency, time-to-ignition and flaming duration) categorized the relative flammability of the seven species (including dead Cupressus sempervirens) in five clusters of species from poorly flammable (Pittosporum tobira) to extremely flammable (dead Cupressus sempervirens).This study provides useful information for reducing fire risk in WUIs in the study area. PMID:23765042

Ganteaume, Anne; Jappiot, Marielle; Lampin, Corinne; Guijarro, Mercedes; Hernando, Carmen

2013-08-01

114

Flammability of Some Ornamental Species in Wildland-Urban Interfaces in Southeastern France: Laboratory Assessment at Particle Level  

NASA Astrophysics Data System (ADS)

Assessment of the flammability of ornamental vegetation (particularly hedges) planted around houses is necessary in light of the increasing urbanization of the wildland-urban interfaces (WUIs) and the high fire occurrence in such areas. The structure and flammability of seven of the species most frequently planted as hedges in Provence (southeastern France) were studied at particle level. Spatial repartition of the different types of fuel particles within plants was assessed by means of the cube method. The leaf flammability was assessed using an epiradiator as a burning device, and measurements of foliar physical characteristics and gross heat of combustion (GHC) helped to explain the results of burning experiments. Co-inertia analysis revealed that species with thin leaves were quick to ignite ( Pyracantha coccinea, Phyllostachys sp.) and species with high leaf GHC burned the longest ( Pittosporum tobira, Nerium oleander). Species presenting high ignitability ( Photinia fraseri, Phyllostachys sp. and Pyracantha coccinea) were characterized by high foliar surface area-to-volume ratio, and species presenting lower ignitability were characterized by high GHC ( Pittosporum tobira, Nerium oleander, Cupressus sempervirens). Hierarchical cluster analysis of the flammability variables (ignition frequency, time-to-ignition and flaming duration) categorized the relative flammability of the seven species (including dead Cupressus sempervirens) in five clusters of species from poorly flammable ( Pittosporum tobira) to extremely flammable (dead Cupressus sempervirens).This study provides useful information for reducing fire risk in WUIs in the study area.

Ganteaume, Anne; Jappiot, Marielle; Lampin, Corinne; Guijarro, Mercedes; Hernando, Carmen

2013-08-01

115

Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species  

PubMed Central

Background: The anticancer properties of Apocynaceae species are well known in barks and roots but less so in leaves. Materials and Methods: In this study, leaf extracts of 10 Apocynaceae species were assessed for antiproliferative (APF) activities using the sulforhodamine B assay. Their extracts were also analyzed for total alkaloid content (TAC), total phenolic content (TPC), and radical scavenging activity (RSA) using the Dragendorff precipitation, Folin–Ciocalteu, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays, respectively. Results: Leaf extracts of Alstonia angustiloba, Calotropis gigantea, Catharanthus roseus, Nerium oleander, Plumeria obtusa, and Vallaris glabra displayed positive APF activities. Extracts of Allamanda cathartica, Cerbera odollam, Dyera costulata, and Kopsia fruticosa did not show any APF activity. Dichloromethane (DCM) extract of C. gigantea, and DCM and DCM:MeOH extracts of V. glabra showed strong APF activities against all six human cancer cell lines. Against breast cancer cells of MCF-7 and MDA-MB-231, DCM extracts of C. gigantea and N. oleander were stronger than or comparable to standard drugs of xanthorrhizol, curcumin, and tamoxifen. All four extracts of N. oleander were effective against MCF-7 cells. Extracts of Kopsia fruticosa had the highest TAC while those of Dyera costulata had the highest TPC and RSA. Extracts of C. gigantea and V. glabra inhibited the growth of all six cancer cell lines while all extracts of N. oleander were effective against MCF-7 cells. Conclusion: Extracts of C. gigantea, V. glabra, and N. oleander therefore showed great promise as potential candidates for anticancer drugs. The wide-spectrum APF activities of these three species are reported for the first time and their bioactive compounds warrant further investigation.

Wong, Siu Kuin; Lim, Yau Yan; Abdullah, Noor Rain; Nordin, Fariza Juliana

2011-01-01

116

Documenting Endangered Languages (DEL)  

NSF Publications Database

Full Proposal Preparation Instructions: This solicitation contains information that supplements the standard Grant Proposal Guide (GPG) proposal preparation guidelines. All DEL proposals for project grants and fellowships will receive specialist (ad hoc) and panel review within the NSF review process. More comprehensive information on NSF Award Conditions is contained in the NSF Grant Policy Manual (GPM) Chapter II, available electronically on the NSF Website at http://www.nsf.gov/...

117

Nevado del Huila, Columbia  

NASA Technical Reports Server (NTRS)

Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

118

Combining experimental evolution and field population assays to study the evolution of host range breadth.  

PubMed

Adapting to specific hosts often involves trade-offs that limit performance on other hosts. These constraints may either lead to narrow host ranges (i.e. specialists, able to exploit only one host type) or wide host ranges often leading to lower performance on each host (i.e. generalists). Here, we combined laboratory experiments on field populations with experimental evolution to investigate the impact of adaptation to the host on host range evolution and associated performance over this range. We used the two-spotted spider mite, Tetranychus urticae, a model organism for studies on the evolution of specialization. Field mite populations were sampled on three host plant species: tomato, citrus tree and rosebay (Nerium oleander). Testing these populations in the laboratory revealed that tomato populations of mites could exploit tomato only, citrus populations could exploit citrus and tomato whereas Nerium populations could exploit all three hosts. Besides, the wider niche ranges of citrus and Nerium populations came at the cost of low performance on their non-native hosts. Experimental lines selected to live on the same three host species exhibited similar patterns of host range and relative performance. This result suggests that adaptation to a new host species may lead to wider host ranges but at the expense of decreased performance on other hosts. We conclude that experimental evolution may reliably inform on evolution in the field. PMID:24689448

Fellous, S; Angot, G; Orsucci, M; Migeon, A; Auger, P; Olivieri, I; Navajas, M

2014-05-01

119

Boletín del Instituto Nacional del Cáncer - 02-02-2010  

Cancer.gov

En un estudio clínico en fase inicial que probó una vacuna terapéutica en pacientes con leucemia mieloide crónica (LMC) que tomaban el fármaco imatinib (Gleevec), no se pudieron detectar células cancerosas en 7 de los 19 participantes por un tiempo promedio de 22 meses. Los resultados del estudio fueron publicados en el número del 1º de enero de la revista Clinical Cancer Research.

120

Vacunas contra los virus del papiloma humano  

Cancer.gov

Hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.

121

Phase Transitions in Thylakoid Polar Lipids of Chilling-Sensitive Plants  

PubMed Central

The phase behavior of thylakoid polar lipids from plants sensitive to chilling injury was investigated by calorimetry, electron spin resonance spectroscopy of spin labels, and fluorescence intensity after labeling with trans-parinaric acid. The plants used were oleander (Nerium oleander), mung bean (Vigna radiata L. var Mungo), and tomato (Lycopersicon esculentum cv Grosse Lisse). For all plants the initiation temperature for the calorimetric exotherm was coincident (±1°C) with the transition determined by the increase in the temperature coefficient of spin label motion and fluorescence intensity of trans-parinaric acid. For oleander plants, grown at 45°C, the transition was at 7°C while for plants from the same clone, grown at 20°C, it was at ?2°C. For mung bean and tomato the transition was between 9 and 12°C. The similarity in the transition detected by spin labeling and fluorescence intensity suggest that spin labels, like the fluorescent label trans-parinaric acid, preferentially partition into domains of ordered lipid. The coincidence of the temperature for initiation of the transition, determined by the three techniques, shows that each is a valid method of assessing a phase transition in membrane polar lipids.

Raison, John K.; Orr, Glenda R.

1986-01-01

122

Siga adelante: la vida después del tratamiento del cáncer  

Cancer.gov

Consejos para supervivientes de cáncer con información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.

123

Siga adelante: la vida después del tratamiento del cáncer  

Cancer.gov

E-book con consejos para supervivientes de cáncer e información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.

124

Boletín del Instituto Nacional del Cáncer - 05-25-2010  

Cancer.gov

Aproximadamente 41.000 participantes en un estudio en el Reino Unido se sometieron una sola vez a una examen de detección en la parte inferior del colon mediante el uso de un sigmoidoscopio, un instrumento delgado en forma de tubo que se inserta a través del recto para buscar lesiones precancerosas o cancerosas. Este dispositivo también tiene una herramienta para extraer pólipos potencialmente precancerosos.

125

Se da a conocer el plan del Instituto Nacional del Cáncer para acelerar la investigación del cáncer  

Cancer.gov

En la 100va Reunión Anual de la Asociación Estadounidense de Investigación del Cáncer realizada en Denver, el director del Instituto Nacional del Cáncer, doctor John E. Niederhuber, dio a conocer detalles importantes, tales como financiamiento de más subvenciones, creación de una plataforma para atención personalizada del cáncer y un programa acelerado de genética del cáncer que hará avanzar la investigación oncológica en este nuevo ambiente económico.

126

MODELADO Y SIMULACION DEL SISTEMA CARDIOVASCULAR FETAL  

Microsoft Academic Search

Resumen: En el modelado fisiológico, el propósito es comprender las funciones del cuerpo humano. Con este propósito, se abordan problemas del embarazo y el parto para minimizar las cesáreas innecesarias en mujeres propensas a cursar con Sufrimiento Fetal Agudo (SFA). En el presente estudio se realizó: el Modelado Matemático del Sistema Cardiovascular Fetal (SCVF), la Simulación y Validación del SCVF.

Rubén Moreno

127

Antioxidantes y prevención del cáncer  

Cancer.gov

Hoja informativa acerca de los antioxidantes, sustancias que pueden proteger las células del daño causado por moléculas inestables conocidas como radicales libres. El daño de los radicales libres puede resultar en cáncer.

128

Case Study: del Amo Bioventing  

EPA Science Inventory

The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study....

129

Alberto del Pozo  

NSDL National Science Digital Library

The Cuban Heritage Collection of the University of Miami Libraries was a recipient of 17 original illustrations by Alberto del Pozo in 1998 from the Campilli family. "The Oricha Collection" is their gift, and it contains illustrations in pen, crayon, and ink and the collection "pays homage to the primary gods and goddesses that comprise the Afro-Cuban religion of Santer'a." The "Introduction" near the top of the page, is a good place for visitors to start learning about Pozo, who was a Parson's School of Design-trained, Cuban artist who died at the age of 47. The "Biographical Sketch" is worth looking at as well. Examples of his colorful, heavily patterned and symbolism-intensive drawings of Santeria gods and goddesses can be found in the link "Gallery". The description of each drawing is given in English and Spanish. Finally, visitors interested in more information on the Santeria, can look at the "Further Readings" link for authoritative books on the subject.

130

Boletín del Instituto Nacional del Cáncer - 28 de febrero de 2012  

Cancer.gov

Los artículos originales en inglés están disponibles en las páginas del NCI Cancer Bulletin. El Boletín es una publicación del Instituto Nacional del Cáncer (NCI), una entidad gubernamental de los Estados Unidos creada en 1937.

131

Assessing and ranking the flammability of some ornamental plant species to select firewise plants for landscaping in WUI (SE France).  

NASA Astrophysics Data System (ADS)

The increasing urbanization of Wildland-Urban Interfaces (WUI) as well as the high fire occurrence in these areas requires the assessment and the ranking of the flammability of the ornamental vegetation surrounding houses especially that planted in hedges. Thus, the flammability of seven species, among those most frequently planted in hedges in Provence (South-Eastern France), were studied at particle level and at dead surface fuel level (litters) under laboratory conditions. The flammability parameters (ignition frequency, time-to-ignition, flaming duration) of the very fine particles (live leaves and particles <2 mm in diameter) were measured using an epiradiator as burning device. The flammability parameters (ignition frequency, time-to-ignition, flaming duration and initial flame propagation) of the undisturbed litter samples were recorded during burning experiments performed on fire bench. Burning experiments using the epiradiator showed that live leaves of Phyllostachys sp., Photinia frasei and Prunus laurocerasus had the shortest time-to-ignition and the highest ignition frequency and flaming duration whereas Pittosporum tobira and Nerium oleander were the longest to ignite with a low frequency. Phyllostachys sp. and Nerium oleander litters were the shortest to ignite while Prunus laurocerasus litter had the lowest bulk density and long time-to-ignition, but high flame propagation. Photinia fraseri litter ignited frequently and had a high flame spread while Pittosporum tobira litter ignited the least frequently and for the shortest duration. Cupressus sempervirens litter had the highest bulk density and the longest flaming duration but the lowest flame propagation. Pyracantha coccinea litter was the longest to ignite and flame propagation was low but lasted a long time. Hierarchical cluster analysis performed on the flammability parameters of live leaves and of litters ranked the seven species in four distinct clusters from the most flammable (Prunus laurocerasus and Pyracantha coccinea) to the least flammable (Pittosporum tobira and Nerium oleander); the other species displaying two groups of intermediate flammabilities (Phyllostachys sp.- Photinia fraseri and Cupressus sempervirens ). The species with highly flammable characteristics should not be used in hedges planted in WUIs in South-Eastern France.

Ganteaume, A.; Jappiot, M.; Lampin, C.

2012-04-01

132

Boletín del Instituto Nacional del Cáncer - 01-05-2010  

Cancer.gov

Al caminar por los pasillos del nuevo centro oncológico integral en la sede de Ciencias Médicas de la Universidad de Puerto Rico (UPR) en San Juan, uno debe mantener los ojos abiertos. La mujer que pasa caminando vigorosamente podría ser la doctora Marcia Roxana Cruz-Correa, y no debe uno perderse la oportunidad de conocerla.

133

Boletín del Instituto Nacional del Cáncer - 04-27-2010  

Cancer.gov

Cada vez es más evidente que los esfuerzos mundiales de salud de mayor éxito dependen no solo del aporte de las mentes más brillantes, sino de la colaboración entre ellas para marcar la diferencia en el escenario global. Este enfoque es el motor impulsor detrás de una asociación excepcional con el NCI, financiada en parte por Susan G.

134

La Investigación del Cáncer en América Latina  

Cancer.gov

Este programa busca fomentar los esfuerzos locales y mundiales de prevención, diagnóstico y tratamiento del cáncer facilitando la creación de una infraestructura integral para la investigación del cáncer en América Latina.

135

Instantánea del cáncer de cuello uterino  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

136

Instantánea del cáncer de seno (mama)  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

137

Geología y registros magnéticos entre arroyo La Tapera y Santa Clara del Mar, Mar del Plata  

Microsoft Academic Search

Geology and magnetic records between Arroyo La Tapera and Santa Clara del Mar, Mar del Plata. Paleomagnetic studies were carried out in Pleistocene-Holocene sedimentary sequences exposed between Arroyo La Tapera and Santa Clara del Mar in Mar del Plata. The sediments exposed in the lower part of the La Tapera and Camet sections, which apparently belong to the Ensenada Formation,

Juan Carlos BIDEGAIN; Margarita L. OSTERRIETH; Adrianus J. VAN VELZEN; Yamile RICO

138

Variabilità interannuale del fi toplancton del Lago di Tovel (Trentino, Italia)  

Microsoft Academic Search

RIASSUNTO - Variabilità interannuale del fi toplancton del Lago di Tovel (Trentino, Italia) - Lo studio del fi toplancton del Lago di Tovel nel periodo 2002-2004 ha avuto come principali obiettivi l'analisi della variabilità interannuale delle dinamiche stagionali nel Bacino Principale e nella Baia Rossa, il confronto tra le associazioni fi toplanctoniche attuali e passate (prima e dopo la scomparsa

Monica TOLOTTI; Dámaso CALLIARI; Flavio CORRADINI

139

Características del desplazamiento forzado en Colombia  

Microsoft Academic Search

RESUMEN El presente estudio es una contribución a la explicación y comprensión de la problemática del desplazamiento forzado interno en Colombia, fenómeno considerado como violación masiva y múltiple de los derechos humanos, circunstancia de lesa humanidad además de ser infracción grave del Derecho Internacional Humanitario. Se identificaron los antecedentes históricos, la dinámica regional del fenómeno, la existencia de factores estructurales

Henry Fernández Pinto; JIMMY SÁNCHEZ REYEZ

2011-01-01

140

Del Mar College GIS Program  

NSDL National Science Digital Library

Del Mar College offers a comprehensive geospatial program with certificates and Associates degrees in GIS. This site includes description of the program and courses, along with further contact information. By clicking on the link for "Geographic Information Systems" you may download a PDF with information about the program.

2010-10-28

141

Los cuatro entornos del procomún  

Microsoft Academic Search

Bastan unos minutos para entender la inmensa complejidad que tiene la noción de procomún. Disponemos de muchas definiciones aceptables, aunque las más frecuentes bordean de una u otra manera el problema de la propiedad y la teoría del valor. Cuando decimos que pertenece al procomún todo cuanto es de todos y de nadie a mismo tiempo estamos pensando en un

Antonio Lafuente

142

Detection of poisoning by plant-origin cardiac glycoside with the Abbott TDx analyzer.  

PubMed

Cardiac glycoside poisoning caused by ingestion of plant material is common in tropical and sub-tropical areas. In evaluating the use of the Abbott TDx Digoxin II assay to detect such cases of poisoning, we found it a rapid and convenient method for confirming the ingestion of glycosides from the plants Nerium oleander, Thevetia peruviana, and Adonis microcarpa, and from the toad Bufo marinus. Here we report some clinical cases illustrating our experience with the use of this assay, and describe results of cross-reactivity studies with compounds structurally similar to digoxin. Because of the competitive nature of the immunoassay as well as the complexity of the mixture of cross-reacting cardiac glycosides present in the plant material, the measured apparent digoxin concentration is not linearly related to the cardiac glycoside concentration. PMID:2914377

Cheung, K; Hinds, J A; Duffy, P

1989-02-01

143

Trasformazioni e patologie del paesaggio  

Microsoft Academic Search

\\u000a Anche il paesaggio, come vedremo, si evolve. Ma parlare oggi di evoluzione è assai problematico e quindi non si può fare a\\u000a meno di un inquadramento più generale del fenomeno. Quando oggi si parla di evoluzione si presenta sovente un quadro che,\\u000a purtroppo, non ha sempre i caratteri della scienza e un dibattito che, di conseguenza, trascina polemiche anche fra

Vittorio Ingegnoli

144

Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer  

Cancer.gov

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.

145

Aplicación del cálculo de las diferencias al problema del efecto de embalse  

Microsoft Academic Search

Resumen Presentamos una solución numérica del problema del efecto de embalse con ayuda de una ecuación lineal inhomogénea en diferencias finitas de primer orden, suponiendo una ley lineal del desagüe. Este método numérico es de maneje cómodo para un cálculo aproximado.

Hans Ertel

1962-01-01

146

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

147

Strategies of heavy metal uptake by plants growing under industrial emissions.  

PubMed

Total concentrations of Al, Ba, Ca, Cr, Cu, Fe, K, Mg, Mn, Pb and Zn have been estimated in soil (A-horizon) and in leaves and stem samples of two Mediterranean species (Nerium oleander L. and Pinus pinea L.) growing in an industrial area in Spain (Huelva). Both species showed a different behaviour for the elements studied. Bark and leaves of both species acted as excluders of Al, Ba, Cr, Fe and Pb, N. oleander acted as indicator of Cu and Zn and, needles and bark of P. pinea behaved as accumulators of Cu. The enrichment ratio data indicated that Cu in soil and plant was enhanced with anthropogenic activities, with industrial activities being the primary contributor for Cu. All the other elements studied were controlled by natural source variations, but Pb could also be anthropogenically enhanced. Wood did not accumulate pollutants, with the translocation from bark being rather reduced. Uptake patterns of metals into foliage and bark tissues were more or less the same in both species for almost all the studied elements, which indicates that both plant parts could be indifferently used as biomonitors. PMID:17363057

Mingorance, M D; Valdés, B; Oliva, S Rossini

2007-05-01

148

Oleandrin: A cardiac glycosides with potent cytotoxicity.  

PubMed

Cardiac glycosides are used in the treatment of congestive heart failure and arrhythmia. Current trend shows use of some cardiac glycosides in the treatment of proliferative diseases, which includes cancer. Nerium oleander L. is an important Chinese folk medicine having well proven cardio protective and cytotoxic effect. Oleandrin (a toxic cardiac glycoside of N. oleander L.) inhibits the activity of nuclear factor kappa-light-chain-enhancer of activated B chain (NF-?B) in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture. The mechanism of action includes improved cellular export of fibroblast growth factor-2, induction of apoptosis through Fas gene expression in tumor cells, formation of superoxide radicals that cause tumor cell injury through mitochondrial disruption, inhibition of interleukin-8 that mediates tumorigenesis and induction of tumor cell autophagy. The present review focuses the applicability of oleandrin in cancer treatment and concerned future perspective in the area. PMID:24347921

Kumar, Arvind; De, Tanmoy; Mishra, Amrita; Mishra, Arun K

2013-07-01

149

Unexpectedly dangerous escargot stew: oleandrin poisoning through the alimentary chain.  

PubMed

A female, aged 43 and a male, aged 66, experienced gastrointestinal and cardiovascular symptoms after a meal including snail stew. Twelve hours after the ingestion, they presented with nausea, vomiting, diarrhea, and cardiovascular symptoms typical of acute toxic digoxin ingestion and were hospitalized. The man's electrocardiogram was altered, and the woman's was normal. Serum digoxin levels, measured on a Roche COBAS Integra 800 with the Roche On-Line Digoxin reagent, were 1.14 and 1.00 nmol/L, respectively. Potassium levels were normal in both patients. The serum digoxin concentration decreased on the second day, and symptoms resolved on the third day with patients fully recovered (i.e., reversion to a normal sinus rhythm). Cardiac-glycoside-like intoxication symptoms follow the ingestion of leaves or flowers of Nerium oleander. The consumed snails were suspected to be responsible for the intoxication. In the homogenized snail tissue, the concentration expressed in digoxin equivalents was 0.282 nmol/g. The presence of oleandrin and oleandrigenin in the snails was confirmed by liquid chromatography-tandem mass spectrometry analysis, which was performed on a ionic-trap Finnigan LXQ instrument using an electrospray ionization interface. High-pressure liquid chromatographic separation was performed on a C18 column with a gradient of methanol/water. An extract of oleander leaves was used as reference. PMID:17137529

Gechtman, Cecilia; Guidugli, Federico; Marocchi, Alessandro; Masarin, Adriano; Zoppi, Francesco

2006-01-01

150

Fractional Indices of Log del Pezzo Surfaces  

NASA Astrophysics Data System (ADS)

The fractional index of a (possibly singular) Q-Gorenstein del Pezzo surface X is the greatest rational number r such that -K_X\\equiv rH, where H is a primitive Cartier divisor. This paper describes the set of values taken by fractional indices of del Pezzo surfaces with log terminal singularities. Bibliography: 7 titles.

Alekseev, V. A.

1989-06-01

151

Fisiología del embarazo: Interacción materno-infantil  

Microsoft Academic Search

ResumenEn los últimos años los datos han demostrado de qué manera el bienestar vitalicio depende considerablemente del crecimiento y el desarrollo intrauterinos durante la vida dentro del útero. El crecimiento fetal puede alcanzar únicamente su potencial íntegro mediante una interacción adecuada y armonizada entre la madre, la placenta y el feto. Este delicado equilibrio puede ser alterado por varios factores

Irene Cetin; Manuela Cardellicchio

2010-01-01

152

La gestione perioperatoria del paziente diabetico  

Microsoft Academic Search

\\u000a Il continuo aumento dei pazienti diabetici che giungono all’osservazione degli anestesisti rende sempre più importante la\\u000a conoscenza delle patologie comunemente associate al diabete e delle strategie da attuare per mantenere un equilibrio glicemico\\u000a ottimale nel periodo perioperatorio.\\u000a \\u000a \\u000a Per questa ragione, dopo aver sinteticamente descritto il metabolismo del glucosio, verrà trattato in questo capitolo il problema\\u000a del corretto trattamento insulinico del

Biagio Allaria

153

Centro para la Salud Mundial del NCI  

Cancer.gov

El Centro para la Salud Mundial del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para entender y enfrentar la carga que representa el cáncer a nivel mundial.

154

Exploración del Nuevo Laboratorio Científico de Marte  

NASA Video Gallery

Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

155

Dust formation in Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the result of the IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. JHKLM photometry was carried out with 125-cm telescope using a InSb-photometer on:

Shenavrin, V. I.; Taranova, O. G.; Tatarnikov, A. M.

2013-09-01

156

ANÁLISIS DEL ÍNDICE DE DESARROLLO DEL GOBIERNO ELECTRÓNICO EN CUBA Y SU COMPARACIÓN CON DISTINTAS REGIONES Y PAÍSES  

Microsoft Academic Search

Se realiza un estudio comparado del grado de desarrollo del gobierno electrónico en distintas regiones y países del mundo, dedicándole una atención particular al caso Cuba. Para ello se utiliza el Índice de desarrollo de gobierno electrónico (IDGE) establecido por las Naciones Unidas. A partir de los componentes del IDGE que son, el índice de servicios en línea (ISL), el

Alejandro de Armas Suárez; Roberto de Armas Urquiza

2011-01-01

157

Manual del McVCO 1999  

USGS Publications Warehouse

El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

McChesney, P.J.

1999-01-01

158

La capacidad redistributiva y estabilizadora del presupuesto del gobierno central español  

Microsoft Academic Search

El objetivo de este trabajo es estimar los efectos redistributivo y estabilizador\\/asegurador del presupuesto de la Administración Pública Central española en el período 1991-1996 a nivel regional. Este análisis se lleva a cabo para el conjunto del presupuesto a través de los saldos fiscales regionales y, separadamente, para el conjunto de ingresos y gastos y sus principales categorías. La metodología

NURIA BOSCH; MARTA ESPASA; PILAR SORRIBAS

2002-01-01

159

Rapporto del Sottocomitato Ricerca del Workshop Internazionale dell'Occhio Secco (2007)  

Microsoft Academic Search

I membri del Sottocomitato Ricerca del DEWS hanno esaminato i dati in letteratura relativi meccanismi ba- se della malattia dell'occhio secco. Sono state valutate le evidenze scientifiche riguardanti il film lacrimale, la ghian- dola lacrimale primaria e le ghiandole lacrimali accessorie, gli epiteli della superficie oculare (incluse cornea e con- giuntiva), le ghiandole di Meibomio, il sistema dei dotti lacri-

Membri del Sottocomitato Ricerca; Ilene K. Gipson; Pablo Argüeso; Roger Beuerman; Stefano Bonini; Igor Butovich; Reza Dana; Darlene Dartt; Dan Gamache; Bryan Ham; Marcia Jumblatt; Donald Korb; Friederich Kruse; Yoko Ogawa; Friedrich Paulsen; Michael Stern; Deborah F. Sweeney; John Tiffany; John Ubels; Mark Willcox

160

Valoración económica del ruido: una aplicación a través del método de transferencia de beneficios  

Microsoft Academic Search

Este artículo tiene como objetivo realizar una aproximación a la valoración económica de los beneficios de la reducción del ruido generado por infraestructuras de telecomunicaciones en cuatro zonas urbanas del área metropolitana de la ciudad de Medellín (Colombia). Así, mediante el método de transferencia de beneficios, en un horizonte a perpetuidad, se obtuvo un valor económico de $79,40 millones para

Francisco Javier Correa Restrepo; Juan David Osorio Múnera; Bernardo Andrés Patiño Valencia

2011-01-01

161

Efectos del color en la aceptabilidad, artificialidad, dulzor e intensidad del sabor de bebidas lácteas  

Microsoft Academic Search

El objetivo del presente estudio es analizar el efecto de la concentración de colorantes en bebidas lác- teas (batidos de vainilla) y de los parámetros de color, pureza o c ro m a, cl a ridad y tono, sobre las ex- p e c t at ivas del grado de acep t abilidad global de dichas bebidas así como sobre

T. Coello García; C. Díaz Berciano; N. Gómez Pestaña

2000-01-01

162

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy

2012-01-01

163

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.

164

El Servicio de Información sobre el Cáncer del Instituto Nacional del Cáncer  

Cancer.gov

El Servicio de Información del Cáncer (CIS) del Instituto Nacional del Cáncer facilita la información más actualizada y precisa sobre el cáncer a pacientes, a sus familias, al público en general y a profesionales médicos. El CIS brinda respuestas personalizadas a preguntas específicas sobre el cáncer y asistencia a los fumadores que quieren abandonar el hábito. Comuníquese con el CIS al 1-800-422-6237 (1-800-4-CANCER) o al 1-877-448-7848 (1-877-44U-QUIT).

165

La reconstrucción del seno después de una mastectomía  

Cancer.gov

Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

166

Transformación de los programas de estudios clínicos del NCI  

Cancer.gov

Información sobre los programas e iniciativas del NCI que patrocinan, realizan, crean o apoyan estudios clínicos, entre los que se incluyen la Red Nacional de Estudios Clínicos (NCTN) y el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI.

167

Exportaciones del Sector Maderas y Papeles No Tradicional  

Microsoft Academic Search

fueron México (23.0% % de participación), Estados Unidos (15.4%), China (15.1%), Venezuela (8.2%) y Ecuador (8.1%). En conjunto estos cinco países concentraron el 66.8.0% del total de exportaciones del sector. Las ventas hacia los mercados de México, China, Ecuador y Venezuela, fueron superiores a las registradas en el mismo periodo del 2007, creciendo durante los primeros seis meses del año

Millones FOB

168

33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2013 CFR

...1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation and Navigable Waters...DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South...

2013-07-01

169

Boletín del Instituto Nacional del Cáncer - 8 de noviembre de 2011  

Cancer.gov

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.

170

Impacto del conflicto colombiano en los periodistas  

Microsoft Academic Search

Introducción: Este artículo esboza las dificultades que presentan los periodistas colombianos en su trabajo y caracteriza el impacto del conflicto armado colombiano en su relación con este ejercicio profesional. Método: Los autores realizaron 70 entrevistas a algunos periodistas colombianos que cubren el conflicto. Para el análisis de las entrevistas se intentó entender la lógica de su conducta y cómo representan

Ismael Roldán; Diana Sofía Giraldo; Miguel Ángel Flórez

2008-01-01

171

Exámenes selectivos de detección del cáncer colorrectal  

Cancer.gov

Un ejemplo excelente del poder de la investigación de prevención es el progreso sustancial que hemos logrado en la reducción de la incidencia y muerte por cáncer colorrectal, con nuevos conocimientos que iluminan el camino a incluso mayores reducciones en un futuro cercano.

172

Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)  

USGS Publications Warehouse

La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; translated by Rivera, M.C.; Munoz, A.

1998-01-01

173

Boletín del Instituto Nacional del Cáncer - 31 de enero de 2012  

Cancer.gov

Dr. Nils Daulaire Salud mundial a través de la colaboración y el liderazgo Para conmemorar el Día Mundial del Cáncer que tuvo lugar el 4 febrero, el doctor Nils Daulaire, director de la Oficina de Asuntos Internacionales del Departamento de Salud y Servicios Humanos de los Estados Unidos habla sobre las razones por las cuales los Estados Unidos deben participar en iniciativas para mejorar la salud mundial.

174

Comportamiento del Helio en estrellas químicamente peculiares  

NASA Astrophysics Data System (ADS)

Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de los efectos NLTE.

Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.

175

[Orientamento religioso e disturbi del comportamento alimentare].  

PubMed

riassunto. Introduzione. L'obiettivo principale del presente studio caso-controllo è stato quello di valutare le relazioni intercorrenti tra la psicopatologia dei disturbi del comportamento alimentare (DCA) con il differente orientamento religioso: intrinseco ed estrinseco. Metodi. Sono stati confrontati un gruppo di pazienti affetti da DCA (23 con anoressia nervosa, 10 con bulimia nervosa e 39 con disturbo d'alimentazione incontrollata) con un gruppo di controllo di soggetti sani, utilizzando la Religious Orientation Scale (ROS). Risultati. I pazienti affetti da DCA hanno mostrato punteggi più alti nella sottoscala della religiosità estrinseca e minori punteggi nella sottoscala riguardante la religiosità intrinseca rispetto ai controlli sani. Nessuna differenza significativa è stata osservata tra i gruppi di DCA in termini di punteggi ROS. Conclusioni. Punteggi più elevati riscontrati in pazienti con orientamento religioso estrinseco sembrano essere associati con la presenza di DCA, mentre un orientamento religioso di tipo intrinseco sembra rappresentare un fattore protettivo. PMID:25000890

Castellini, Giovanni; Zagaglioni, Alice; Godini, Lucia; Monami, Francesca; Dini, Carla; Faravelli, Carlo; Ricca, Valdo

2014-01-01

176

Del Norte means north to recycling  

SciTech Connect

Del Norte Regional Recycling and Transfer Station is owned by the city of Oxnard, California and operated by BLT Enterprises, Inc. The Del Norte facility--located in southwestern Ventura County about an hour northwest of Los Angeles--processes polyethylene terephthalate (PET) and high-density polyethylene (HDPE) plastic containers, aluminum, steel, glass, old corrugated containers (OCC), newspapers, computer printout paper, white and colored ledger paper, coated book, supermix paper, telephone books, and old magazines. According to the company, there has been virtually no community opposition to the site. The facility has few neighbors, and those are agricultural. To keep the community relationship strong, the facility`s design and location all but eliminated odor and noise complaints. The building was designed against the prevailing wind pattern, and BLT processes odorous material fast. A misting system installed for dust suppression also can be used with a solution for odor control should the need arise.

Aquino, J.T.

1998-06-01

177

Enfoques de programación matemática fuzzy multiobjetivo para la planificación operativa del transporte en una cadena de suministro del sector del automóvil = Fuzzy Multiobjective Mathematical Programming Approaches for Operational Transport Planning in an Automobile Supply Chain  

Microsoft Academic Search

En este trabajo se presenta un modelo de programación matemática fuzzy multiobjetivo para la planificación del transporte a nivel operativo en una cadena de suministro. Los objetivos del modelo propuesto son la minimización del número de camiones utilizados y del inventario total, considerando como parámetro borroso las capacidades de los vehículos empleados. Se propone una metodología de resolución para transformar

Manuel Díaz-Madroñero; David Peidro; Josefa Mula; Francisco J. Ferriols

2010-01-01

178

SISTEMA PARA GESTIONAR LA ACTIVIDAD CIENTÍFICA DEL DEPARTAMENTO DE INFORMÁTICA DE LA UNIVERSIDAD DE GUANTÁNAMO  

Microsoft Academic Search

El sistema para gestionar la actividad científica del Departamento de Informática de la Universidad de Guantánamo surge debido a la necesidad de gestionar de manera más rápida, segura y eficaz los procesos que se desarrollan actualmente en dicho centro. Fue desarrollado utilizando los lenguajes PHP del lado del servidor con CodeIgniter como framework y JavaScript del lado del cliente. Se

Denis Boizan Romero

2012-01-01

179

Epidemiologia della malattia dell'Occhio Secco: Rapporto del Sottocomitato Epidemiologia del Workshop Internazionale dell'Occhio Secco (2007) Epidemiologia  

Microsoft Academic Search

Il rapporto del Sottocomitato Epidemiologia del Workshop dell'Occhio Secco del 2007 riassume le cono- scenze attuali dell'epidemiologia della malattia dell'occhio secco, fornendo i dati di prevalenza e incidenza derivanti da varie popolazioni. Mette in risalto la necessità di allargare gli studi epidemiologici a ulteriori aree geografiche, di incorpo- rare varie razze ed etnie negli studi futuri e di determinare un

Sottocomitato Epidemiologia; Janine A. Smith; Julie Albeitz; Carolyn Begley; Barbara Caffery; Kelly Nichols; Debra Schaumberg; Oliver Schein

180

Descripción del funcionamiento del mercado secundario de bonos soberanos locales en Chile  

Microsoft Academic Search

En este trabajo se describe el funcionamiento del mercado secundario de los bonos de largo plazo soberanos locales. Más específicamente, se describen en profundidad los agentes involucrados, los instrumentos transados y los tipos de plataformas existentes. A partir de este trabajo es posible obtener las siguientes conclusiones. Primero, existe un alto grado de segmentación en el mercado secundario de renta

Sergio D’Acuña; Sergio Godoy; Nicolás Malandre

2009-01-01

181

Eficiencia y determinantes del funcionamiento del mercado paralelo de divisas en Colombia  

Microsoft Academic Search

El presente trabajo analiza la relación entre el tipo de cambio negro y el oficial, al igual que la eficiencia del mercado paralelo de divisas en Colombia. Con base en datos mensuales para el período 1970-1989, se encontró que la tasa de cambio oficial y paralela estaban cointegradas, lo cual implica que el dólar oficial y el negro mantuvieron una

Santiago Herrera

1990-01-01

182

Ajuste estructural y mercado del trabajo: Nigeria después de la crisis del petróleo  

Microsoft Academic Search

En este artículo examinamos la experiencia de Nigeria durante la crisis petrolera de los años 1980 y el comienzo de la aplicación de un paquete de ajuste estructural. Nuestro análisis se concentra en el rol jugado por el mercado del trabajo, particularmente en relación a la situación de empleo y desempleo, como también a los flujos migratorios despertados por la

Paul Collier; Luis Riveros

183

Mujeres en ascenso: dinámica del sistema educativo y del mercado laboral en Colombia, 1900-2000  

Microsoft Academic Search

El objetivo principal de la presente investigación es describir y analizar los cambios en la transmisión de conocimiento en los establecimientos educativos femeninos de Bogotá y la participación de la mujer dentro del mercado laboral bogotano. Con base en los resultados que arrojó la Encuesta de empleo de 1963-1970 para Bogotá y la Encuesta Integrada de hogares 2006, se elaboró

María del Pilar López-Uribe; Diana Quintero Castellanos; Loly Aylú Gaitán Guerrero

2011-01-01

184

La quimera del mezzo termine. La contribución franco-británica a la caída del liberalismo peninsular  

Microsoft Academic Search

En 1823, en un contexto marcado por el temor a despertar del fantasma de la revolución en Europa, pasó a un primer plano la posibilidad de ensayar en la Península fórmulas moderadas de organización política, un mezzo termine que conjugara la renuncia a los principios más revolucionarios con el reconocimientos de ciertos derechos y garantías individuales. El debate creado en

Gonzalo Butrón Prida

2001-01-01

185

Boletín del Instituto Nacional del Cáncer - 11 de septiembre de 2012  

Cancer.gov

Con la ayuda de herramientas genéticas, investigadores han identificado subconjuntos de células que parecen impulsar el crecimiento de tumores en ratones. Estos resultados ofrecen factores adicionales que sustentan la hipótesis de la existencia de células madre del cáncer, es decir, la idea de que algunos tumores contienen células que se autorenuevan y dan origen a todo tipo de células tumorales.

186

Diseño del saneamiento de Urdaibai (País Vasco) bajo una perspectiva de preservación ambiental del litoral  

Microsoft Academic Search

Los sistemas de saneamiento unitarios, del mismo modo que cualquier obra de infraestructura dispuesta a soportar fenómenos naturales, pre- sentan, inevitablemente, una determinada probabilidad de fallo, igual, a la de que los efectos producidos por estos superen a los considerados en su diseño. Por tanto, el comportamiento general de los mismos sólo puede evaluarse en términos probabilísticos. Siendo la lluvia

ANDRÉS GARCÍA; KALIN N. KOEV; JOSÉ A. REVILLA; JOSÉ A. JUANES

187

Alcune osservazioni sulle cause di tenuta del settore del franchising nelle fasi recessive  

Microsoft Academic Search

La ricerca esamina le imprese che operano in franchising attraverso microdati raccolti da Assofranchising, la principale associazione italiana nel campo del franchising. Mediante tecniche esplorative e multivariate si dimostra che, ceteris paribus, un aumento della scala delle reti, basata sulla crescita delle risorse umane e materiali, ha un effetto positivo sull’efficienza aziendale attraverso il miglioramento di indicatori strategici di produttività.

Antonio Bernardi

2011-01-01

188

Tratamiento adyuvante del carcinoma de recto  

Microsoft Academic Search

Resumen\\u000a Objectivo  Neustro objetivo es analizar los resultados del tratamiento adyuvante en pacientes operados por un carcinoma rectal localmente\\u000a avanzado, tratados con radioquimioterapia concomitante o secuencial.\\u000a \\u000a \\u000a \\u000a Material y métodos  Entre enero de 1994 y septiembre de 1997, 122 pacientes fueron tratados postquirúrgicamente por un adenocarcinoma rectal en\\u000a estadio B2-C. Setenta y siete pacientes fueron tratados siguiendo un esquema alternante de quimiorradioterapia y

Javier Valencia Julve; Ricardo Escó Barón; Javier Sanz Lacalle; Miguel Burillo Cordero; Pedro Mateo de las Heras; Carmen Lainez Baquero

2003-01-01

189

UBVJHKLM photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the results of the optical and IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. UBV photometry was carried out with 60-cm Zeiss telescope using a photoelectric photometer on August 15.94 UT: U=4.54+/-0.02, B=5.07+/-0.01, V=5.05+/-0.01; on August 16.80 UT: U=4.54+/-0.01, B=4.85+/-0.02, V=4.68+/-0.01; on August 16.86 UT: U=4.66+/-0.01, B=4.92+/-0.01, V=4.73+/-0.01.

Burlak, A. M.; Shenavrin, I. V.; Tatarnikov, M. A.; Tatarnikova, A. A.

2013-08-01

190

TEMA V TENDENCIAS RECIENTES EN EL MERCADO DE TRABAJO (I): LA CONSTRUCCIÓN SOCIOHISTÓRICA DEL MERCADO DE TRABAJO CONTEMPORÁNEO: DEL FORDISMO AL POSFORDISMO  

Microsoft Academic Search

Este tema presenta un conjunto de cuestiones relacionadas con las transformaciones históricas más recientes del trabajo y del empleo. Intentaremos aquí seguir su trayectoria en la segunda mitad del siglo XX para poder analizar las tendencias más recientes del mercado de trabajo que se proyectan hacia el siglo XXI y que sirven de contexto y de marco de explicación al

Antonio Santos Ortega

191

MÚSICA Y AGRUPACIONES DE CARNAVAL A FINALES DEL SIGLO XX EN ANDALUCÍA OCCIDENTAL. LA REVITALIZACIÓN FESTIVA Y EL RENACIMIENTO DEL CARNAVAL  

Microsoft Academic Search

Con este trabajo pretendemos acercarnos al Carnaval de Andalucía occidental a partir de su recuperación durante la Transición y los gobiernos socialistas en la década de los años ochenta del pasado siglo XX. Este proceso tuvo lugar en un marco de participación ciudadana, modernización económica, estado del bienestar, constitución de las comunidades autónomas, sociedad del espectáculo y del entretenimiento, y

Francisco José García Gallardo

2005-01-01

192

Instantánea de los cánceres de cerebro y del sistema nervioso central  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

193

Particle pollution - An environmental magnetism study using biocollectors located in northern Portugal  

NASA Astrophysics Data System (ADS)

In this study the magnetic properties of tree leaves were measured in order to compare their capability to accumulate particles, to establish the relationship between magnetic properties and chemical data and to assess the particle pollution in selected locations in the cities of Braga, Porto, Valongo and Trancoso-Reboleiro, northern Portugal. In Porto, Braga and Valongo, leaves from the evergreen Nerium oleander were sampled each month during a year. N. oleander and deciduous Quercus spp. and Platanus spp. samples were collected in the same site in Porto, in order to determine the ability of these different leaves to accumulate particles. The leaves of deciduous Tilia spp. were collected in Porto and in a rural area (Trancoso-Reboleiro) so that a comparison could be established between them. The results indicated a contrast between the urban and the rural areas. The highest concentration of magnetic particles was found in the sampling site of Valongo and the lowest concentration in the sampling site of Trancoso-Reboleiro. In Porto, the results have shown that the Quercus leaves possessed the highest capability to accumulate particles even though it is a deciduous species. The IRM acquisition curves and the S-300 ratios found in the samples of the urban areas indicated the presence of magnetite-like structures. SIRM/? ratio revealed particles whose dimensions ranged between 5 ?m and 8 ?m in urban areas. The chemical elements copper and iron have a significant positive correlation with ? and SIRM, which highlights the use of magnetic properties as a proxy for the concentration of these metals in atmospheric dust. The magnetic properties were interpreted taking into consideration the rainfall peaks and then compared with the PM10 concentration levels monitored in an air quality station in Porto. Our data corroborated that magnetic properties provide a fast and inexpensive tool to evaluate long-term urban pollution from anthropogenic origin, especially heavy traffic.

Sant'Ovaia, Helena; Lacerda, Maria João; Gomes, Celeste

2012-12-01

194

Decoding F508del Misfolding in Cystic Fibrosis  

PubMed Central

The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. The F508del misfolding originates in the first nucleotide-binding domain (NBD1), which induces a global conformational change in CFTR through NBD1’s interactions with other domains. Such global misfolding produces a mutant chloride channel that is impaired in exocytic trafficking, peripheral stability, and channel gating. The nature and atomic details of F508del misfolding have been subject to extensive research during the past decade. Current data support a central role for NBD1 in F508del misfolding and rescue. Many cis-acting NBD1 second-site mutations rescue F508del misfolding in the context of full-length CFTR. While some of these mutations appear to specifically counteract the F508del-induced misfolding, others release certain inherent conformational constraints of the human wild-type CFTR. Several small-molecule correctors were recently found to act on key interdomain interfaces of F508del CFTR. Potential rational approaches have been proposed in an attempt to develop highly effective small molecule modulators that improve the cell surface functional expression of F508del CFTR.

Wang, Xiaodong Robert; Li, Chenglong

2014-01-01

195

Conceptos fundamentales del desarrollo de proveedores (Caso de negocios 13)  

Microsoft Academic Search

El desarrollo de proveedores es una actividad que enriquece la gestión de la cadena de suministro, dotándola de mayor valor a través del aporte mutuo entre empresas clientes y subcontratistas. Este aporte incluye nuevas tecnologías, know-how, herramientas de la calidad y organización del trabajo, además de negociaciones sobre la política de precios, entre otros temas. En este trabajo presentamos sus

Enrique Yacuzzi

2012-01-01

196

Fomento de la investigación del cáncer en América Latina  

Cancer.gov

La Oficina para el Desarrollo de Programas de Cáncer en América Latina (OLACPD), fruto de una alianza innovadora entre el Instituto Nacional del Cáncer (NCI) y el Centro Internacional Fogarty (FIC), fue creada en reconocimiento de la oportunidad de apoyar y mejorar la investigación y el tratamiento del cáncer en América Latina.

197

El presidente Obama anuncia nombramiento del doctor Harold Varmus  

Cancer.gov

En los últimos cinco años como director del NCI, y en otras funciones ejercidas durante muchos años, he disfrutado ampliamente cada oportunidad que he tenido de visitar los laboratorios y las oficinas, desde Bethesda hasta Frederick, para conocer en persona a los miembros del personal y compartir mis opiniones sobre temas importantes en torno a la ciencia y al manejo de este gran Instituto.

198

El sistema muscular es el impulsor del desarrollo esquelético  

Microsoft Academic Search

ExtractoEn esta revisión se abordan los conceptos metodológicos de evaluación de la función de la musculatura esquelética y adaptación ósea. Actualmente se considera que la propiedad crítica del hueso no es tanto su peso como su resistencia, y que el control de la resistencia ósea se ejerce principalmente a través del efecto de las cargas mecánicas que inciden sobre el

Eckhard Schoenau

2006-01-01

199

The hydrothermal system of Nevado del Ruiz volcano, Colombia  

Microsoft Academic Search

Hot springs and steam vents on the slopes of Nevado del Ruiz volcano provide evidence regarding the nature of hydrothermal activity within the summit and flanks of the volcano. At elevations below 3000 m, alkali-chloride water is discharged from two groups of boiling springs and several isolated warm springs on the western slope of Nevado del Ruiz. Chemical and isotopic

Neil C. Sturchio; Stanley N. Williams; Nestor P. Garcia; Adela C. Londono

1988-01-01

200

Gestión ambiental de la vitivinicultura: aplicación del cuadro de mando  

Microsoft Academic Search

Resumen La vitivinicultura es una de las principales industrias de San Juan, Argentina. En esta provincia existen más de 266 bodegas. Actualmente, existe mayor conciencia, por parte del consumidor, del proceso de elaboración de un producto, desde el punto de vista medioambiental, sobre todo en países como Estados Unidos y el Reino Unido, los cuales son los principales países importadores

Rosa Ana Rodríguez; Gustavo R. Traconis

2012-01-01

201

An Accretion Disc Model For Eclipsing Binary System: AV Del  

Microsoft Academic Search

We investigate the light and radial-veloci -ty curves of the eclipsing binary AV Del. Using the most new version of Wilson & Van Hamme (2003) code, the absolute elements, fundamental orbital and physical parameters of the system are determined. Then, using the new SHELLSPEC code, we study and present an accretion disc model for the system. We found AV Del

Sayyed Mohammad Reza Ghoreyshi; Jamshid Ghanbari; Fatemeh Salehi

202

Molecular basis of DEL phenotype in the Chinese population  

PubMed Central

Background Rh blood group system is the most complex and immunogenetic blood group system. Prevalent RHD alleles vary in different populations. We conducted the present study to examine the genotype of DEL individuals and to elucidate whether novel alleles exist in the Chinese population. Methods DEL phenotype was identified by a serologic adsorption-elution method. The nucleotide sequences of ten RHD exons and exon-intron boundary regions were evaluated by RHD gene-specific PCR-SSP and sequencing. Results Of 42306 samples from individual donors and patients, 165 samples were typed as D-negative. Among these D-negative samples, 41 DEL individuals were observed. Thirty-seven DELs were confirmed to have the RHD1227A allele. Two DELs seemed to have RHD-CE-D hybrid alleles, including one RHD-CE (4–7)-D and one RHD-CE (2–5)-D. Two novel RHD alleles were found among the rest of the DEL samples, including one RHD93T?>?A and one RHD838G?>?A. Conclusion In this study, about 24.85% (41/165) of the apparent D-negative Chinese individuals were DEL. RHD1227G?>?A is the most frequent allele in Chinese DEL phenotypes, accounting for 90.24% (37/41). The RHD-CE-D hybrid allele might be the second most frequent DEL allele in the Chinese population. Our study would contribute to the understanding of the molecular mechanism underlying D antigen expression of DEL individuals and provide useful information for designing suitable genotyping strategies in RhD-negative individuals in Asia.

2014-01-01

203

El Instituto Nacional del Cáncer de EE. UU. y la República del Perú firman una Declaración de Intención  

Cancer.gov

El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común de educar y capacitar la futura generación de científicos y clínicos en investigación oncológica.

204

La dimensione del tumore è predittiva della sopravvivenza nel tumore del polmone non a piccole cellule in stadio IA  

Microsoft Academic Search

Oggetto dello studio: La premessa base dello screening mediante TC è che la dimensione sia una determinante importante della sopravvivenza per il cancro del polmone. Noi abbiamo cer- cato di esaminare questa ipotesi per il tumore del polmone non a piccole cellule (NSCLC) in stadio IA. Metodi: È stata condotta una analisi retrospettiva di tutti i pazienti con NSCLC istologicamente

Jeffrey L. Port; Michael S. Kent; Robert J. Korst; Daniel Libby; Mark Pasmantier; Nasser K. Altorki

2004-01-01

205

[Strengths and future of the Revista Médica del Instituto Mexicano del Seguro Social].  

PubMed

The journals of medicine arose as a communication tool more than 200 years ago. At the beginning, their nature was local; later, their aim was to spread medical information along the nation; and, finally, they sought to reach the world distribution. The Revista Médica del Instituto Mexicano del Seguro Social was published for the first time 52 years ago, and it has walked its way from local to international distribution. This journal has 23 000 subscribers, it is included in Medline and it reached a 0.112 SCImago Journal Rank in 2012. Its website receives around 200 000 visits monthly and 45 % are foreign visits. In the future, the peer review system is going to be strengthened, and the journal is going to offer audio, video, and applications to reinforce interactive participation between authors, readers in order to reach modernity and draw young new attention. PMID:24758842

Fajardo-Dolci, Germán

2014-01-01

206

El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto

2009-01-01

207

La teoría de juegos conductual, el dilema del viajero alternativo y la maximización de pagos  

Microsoft Academic Search

Dentro del área de teoría de juegos conductual nos enfocamos en un contexto específico, el del juego que denominamos Dilema del viajero alternativo. En este contexto hemos observado que los participantes tienden a elegir estrategias estrictamente dominadas. Para explicar tendencias similares en otros juegos, los investigadores del área han apelado a sesgos cognitivos o bien a factores motivacionales. Proponemos un

Rodrigo Moro; Esteban Freidin; Fernando Tohmé; Marcelo Auday

208

Doctor Harold Varmus, director del NCI: Bienvenidos a Cancer.gov en español  

Cancer.gov

El director del NCI, doctor Harold Varmus, da la bienvenida a los visitantes al sitio web del NCI y habla sobre la complejidad del cáncer, así como de los avances alcanzados gracias a las nuevas herramientas y tecnologías para la investigación del cáncer.

209

Antenatal Rh prophylaxis is unnecessary for “Asia type” DEL women  

Microsoft Academic Search

BackgroundGenerally Rh-negative patients need to be transfused with Rh-negative red blood cells. For pregnant women carrying Rh-positive fetus, the antenatal anti-D detection and Rh immunoglobulin prophylaxis are required worldwide. In East Asia, a RhD variant, termed “Asia type” DEL, was found in approximately 30% of apparent Rh-negative individuals. The antigenic and molecular properties of the DEL were previously defined. Few

Chao-Peng Shao; Hua Xu; Qun Xu; Guo-Dong Sun; Jian-Ping Li; Bo-Wei Zhang; Xiao-Hua Liang; Zhong Liu; Ying Zhou; Dan Li; Nai-Bao Zhuang

2010-01-01

210

Arthrobacter siccitolerans sp. nov., a highly desiccation-tolerant, xeroprotectant-producing strain isolated from dry soil.  

PubMed

A novel desiccation-tolerant, xeroprotectant-producing bacterium, designated strain 4J27(T), was isolated from a Nerium oleander rhizosphere subjected to seasonal drought in Granada, Spain. Phylogenetic analysis based on 16S rRNA gene sequencing placed the isolate within the genus Arthrobacter, its closest relative being Arthrobacter phenanthrenivorans Shep3 DSM 18606(T), with which it showed 99.23?% 16S rRNA gene sequence similarity. DNA-DNA hybridization measurements showed less than 25?% relatedness between strain 4J27(T) and Arthrobacter phenanthrenivorans DSM 18606(T). The DNA base composition of strain 4J27(T) was 65.3 mol%. The main fatty acids were anteiso C15?:?0, anteiso C17?:?0, C16?:?0 and iso C16?:?0 and the major menaquinone was MK-9 (H2). The peptidoglycan type was A3? with an l-Lys-l-Ser-l-Thr-l-Ala interpeptide bridge. The bacterium tested positive for catalase activity and negative for oxidase activity. Phylogenetic, chemotaxonomic and phenotypic analyses indicated that the desiccation-tolerant strain 4J27(T) represents a novel species within the genus Arthrobacter, for which the name Arthrobacter siccitolerans is proposed. The type strain is 4J27(T) (?=?CECT 8257(T)?=?LMG 27359(T)). PMID:23771623

Santacruz-Calvo, L; González-López, J; Manzanera, M

2013-11-01

211

BDNF Mediates Neuroprotection against Oxygen-Glucose Deprivation by the Cardiac Glycoside Oleandrin  

PubMed Central

We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro and in vivo brain slice-based models for focal ischemia (Dunn et al., 2011). Intriguingly, plasma levels of the neurotrophin BDNF were increased in patients treated with PBI-05204 in a phase I clinical trial (Bidyasar et al., 2009). We thus tested the hypothesis that neuroprotection provided by PBI-05204 to rat brain slices damaged by oxygen-glucose deprivation (OGD) is mediated by BDNF. We found, in fact, that exogenous BDNF protein itself is sufficient to protect brain slices against OGD, whereas downstream activation of TrkB receptors for BDNF is necessary for neuroprotection provided by PBI-05204, using three independent methods. Finally, we provide evidence that oleandrin, the principal cardiac glycoside component of PBI-05204, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. Together, these findings support further investigation of cardiac glycosides in providing neuroprotection in the context of ischemic stroke.

Van Kanegan, Michael J.; He, Dong Ning; Dunn, Denise E.; Yang, Peiying; Newman, Robert A.; West, Anne E.

2014-01-01

212

BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.  

PubMed

We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro and in vivo brain slice-based models for focal ischemia (Dunn et al., 2011). Intriguingly, plasma levels of the neurotrophin BDNF were increased in patients treated with PBI-05204 in a phase I clinical trial (Bidyasar et al., 2009). We thus tested the hypothesis that neuroprotection provided by PBI-05204 to rat brain slices damaged by oxygen-glucose deprivation (OGD) is mediated by BDNF. We found, in fact, that exogenous BDNF protein itself is sufficient to protect brain slices against OGD, whereas downstream activation of TrkB receptors for BDNF is necessary for neuroprotection provided by PBI-05204, using three independent methods. Finally, we provide evidence that oleandrin, the principal cardiac glycoside component of PBI-05204, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. Together, these findings support further investigation of cardiac glycosides in providing neuroprotection in the context of ischemic stroke. PMID:24431454

Van Kanegan, Michael J; He, Dong Ning; Dunn, Denise E; Yang, Peiying; Newman, Robert A; West, Anne E; Lo, Donald C

2014-01-15

213

[Selection and purification potential evaluation of woody plant in vertical flow constructed wetlands in the subtropical area].  

PubMed

In order to solve the problem that wetland herbaceous plants tend to die during winter in subtropics areas, selection and purification potential evaluation experiments were carried out by introducing into the constructed wetlands 16 species of woody wetland plants. Cluster analysis was performed by including the morphological characteristics, physiological characteristics, as well as nitrogen and phosphorus accumulation of the woody wetland plants. The results indicated that there were significant differences among the tested woody plants in their survival rate, height increase, root length increase and vigor, Chlorophyll content, Superoxide dismutase, Malonaldehyde, Proline, Peroxidase, biomass, average concentration and accumulation of nitrogen and phosphorus. Based on the established evaluation system, the tested plants were clustered into 3 groups. The plants in the 1st group possessing high purification potentials are Nerium oleander and Hibiscus syriacus. Those in the 2nd group possessing moderate purification potentials are Trachycarpus fortune, Llex latifolia Thunb., Gardenia jasminoides, Serissa foetida and Ilex crenatacv Convexa. And those in the 3rd group with low purification potentials are Jasminum udiflorum, Hedera helix, Ligustrum vicaryi, Ligustrum lucidum, Buxus sempervives, Murraya paniculata, Osmanthus fragrans, Mahoniafortune and Photinia serrulata. PMID:24812951

Chen, Yong-Hua; Wu, Xiao-Fu; Hao, Jun; Chen, Ming-Li; Zhu, Guang-Yu

2014-02-01

214

Arthrobacter siccitolerans sp. nov., a highly desiccation-tolerant, xeroprotectant-producing strain isolated from dry soil  

PubMed Central

A novel desiccation-tolerant, xeroprotectant-producing bacterium, designated strain 4J27T, was isolated from a Nerium oleander rhizosphere subjected to seasonal drought in Granada, Spain. Phylogenetic analysis based on 16S rRNA gene sequencing placed the isolate within the genus Arthrobacter, its closest relative being Arthrobacter phenanthrenivorans Shep3 DSM 18606T, with which it showed 99.23?% 16S rRNA gene sequence similarity. DNA–DNA hybridization measurements showed less than 25?% relatedness between strain 4J27T and Arthrobacter phenanthrenivorans DSM 18606T. The DNA base composition of strain 4J27T was 65.3 mol%. The main fatty acids were anteiso C15?:?0, anteiso C17?:?0, C16?:?0 and iso C16?:?0 and the major menaquinone was MK-9 (H2). The peptidoglycan type was A3? with an l-Lys–l-Ser–l-Thr–l-Ala interpeptide bridge. The bacterium tested positive for catalase activity and negative for oxidase activity. Phylogenetic, chemotaxonomic and phenotypic analyses indicated that the desiccation-tolerant strain 4J27T represents a novel species within the genus Arthrobacter, for which the name Arthrobacter siccitolerans is proposed. The type strain is 4J27T (?=?CECT 8257T?=?LMG 27359T).

SantaCruz-Calvo, L.; Gonzalez-Lopez, J.

2013-01-01

215

Ephedra alte (Joint Pine): An Invasive, Problematic Weedy Species in Forestry and Fruit Tree Orchards in Jordan  

PubMed Central

A field survey was carried out to record plant species climbed by Ephedra alte in certain parts of Jordan during 2008–2010. Forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of E. alte. Growth of host plants was adversely affected by E. alte growth that extended over their vegetation. In addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, smothers growth and makes plants die underneath the extensive cover. However, E. alte did not climb all plant species, indicating a host preference range. Damaged fruit trees included Amygdalus communis, Citrus aurantifolia, Ficus carica, Olea europaea, Opuntia ficus-indica, and Punica granatum. Forestry species that were adversely affected included Acacia cyanophylla, Ceratonia siliqua, Crataegus azarolus, Cupressus sempervirens, Pinus halepensis, Pistacia atlantica, Pistacia palaestina, Quercus coccifera, Quercus infectoria, Retama raetam, Rhamnus palaestina, Rhus tripartita, and Zizyphus spina-christi. Woody ornamentals attacked were Ailanthus altissima, Hedera helix, Jasminum fruticans, Jasminum grandiflorum, Nerium oleander, and Pyracantha coccinea. Results indicated that E. alte is a strong competitive for light and can completely smother plants supporting its growth. A. communis, F. carica, R. palaestina, and C. azarolus were most frequently attacked.

Qasem, Jamal R.

2012-01-01

216

Zeaxanthin and the Induction and Relaxation Kinetics of the Dissipation of Excess Excitation Energy in Leaves in 2% O2, 0% CO21  

PubMed Central

The relationship between the carotenoid zeaxanthin, formed by violaxanthin de-epoxidation, and nonphotochemical fluorescence quenching (qNP) in the light was investigated in leaves of Glycine max during a transient from dark to light in 2% O2, 0% CO2 at 100 to 200 micromoles of photons per square meter per second. (a) Up to a qNP (which can vary between 0 and 1) of about 0.7, the zeaxanthin content of leaves was linearly correlated with qNP as well as with the rate constant for radiationless energy dissipation in the antenna chlorophyll (kD). Beyond this point, at very high degrees of fluorescence quenching, only kD was directly proportional to the zeaxanthin content. (b) The relationship between zeaxanthin and kD was quantitatively similar for the rapidly relaxing quenching induced in 2% O2, 0% CO2 at 200 micromoles of photons per square meter per second and for the sustained quenching induced by long-term exposure of Nerium oleander to drought in high light (B Demmig, K Winter, A Krüger, F-C Czygan [1988] Plant Physiol 87: 17-24). These findings suggest that the same dissipation process may be induced by very different treatments and that this particular dissipation process can have widely different relaxation kinetics. (c) A rapid induction of strong nonphotochemical fluorescence quenching within about 1 minute was observed exclusively in leaves which already contained a background level of zeaxanthin.

Demmig-Adams, Barbara; Winter, Klaus; Kruger, Almuth; Czygan, Franz-Christian

1989-01-01

217

Genetic differentiation in Tetranychus urticae (Acari: Tetranychidae): polymorphism, host races or sibling species?  

PubMed

Based on allozyme electrophoresis at the Pgm locus and nuclear ribosomal DNA (ITS2) sequences, we studied the genetic variation of the two-spotted spider mite Tetranychus urticae Koch collected on rose bay, Nerium oleander L. (Apocynaceae), from several localities around the Mediterranean basin. In addition, we compared these results with those of Navajas et al. (1998) and Tsagkarakou (1997) who collected from several other host plants from the Mediterranean. In the western part of this area (Spain, France, Tunisia), we found the individuals collected from rose bay to be clearly genetically differentiated from other samples. No evidence of such host-associated differentiation was detected in the eastern Mediterranean (Italy and Greece). The genetic differentiation of mites collected on rose bay was investigated further by studying the reproductive incompatibilities between populations in Greece and in France and a laboratory strain reared on bean, Phaseolus vulgaris, in France. Reciprocal crosses performed between these strains revealed variable levels of incompatibility, spanning from partial to complete reproductive isolation. In all cases incompatibility was asymmetric. We designed a test based on double-mating to establish the fertilization status of females in fully incompatible crosses. These crosses showed that the females had been inseminated, which suggests that the barrier to reproduction is not of a prezygotic behavioral nature. The data raises the question of the relative role of ecological factors (host plant) and geographical distance, in the ongoing differentiation process potentially leading to speciation. PMID:11156162

Navajas, M; Tsagkarakov, A; Lagnel, J; Perrot-Minnot, M J

2000-01-01

218

Testing a vapour-phase model of stomatal responses to humidity.  

PubMed

This study tests two predictions from a recently proposed model for stomatal responses to humidity and temperature. The model is based on water potential equilibrium between the guard cells and the air at the bottom of the stomatal pore and contains three independent variables: gs(0), Z and ?. gs(0) is the value of stomatal conductance that would occur at saturating humidity and will vary among leaves and with CO2 and light. The value of Z is determined primarily by the resistance to heat transfer from the epidermis to the evaporating site and the value of ? is determined primarily by the resistance to water vapour diffusion from the evaporating site to the guard cells. This leads to the two predictions that were tested. Firstly, the values of Z and ? should be constant for leaves of a given species grown under given conditions, although gs(0) should vary among leaves and with light and CO2. And secondly, the ratio of Z to ? should be higher in leaves having their stomata in crypts because the distance for heat transfer is greater than that for water vapour diffusion. Data from three species, Nerium oleander, Pastinaca sativum and Xanthium strumarium support these two predictions. PMID:23072325

Mott, Keith A; Peak, David

2013-05-01

219

Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades  

NASA Astrophysics Data System (ADS)

A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

Cirigliano, D.; Vial, J. C.; Rovira, M.

220

Peat soil flows in Bahía del Buen Suceso, Tierra del Fuego (Argentina)  

NASA Astrophysics Data System (ADS)

On the southeastern edge of Tierra del Fuego, a mountainous area with a cold humid oceanic climate, peat soils cover not only flat areas but also steep hillslopes under an evergreen Nothofagus betuloides forest. Peat flows in the form of chutes are very frequent on these hillslopes. Some data were gathered on the field for 11 of these movements and from aerial photographs for 21 of them. The results suggest that peat soils become unstable when thickness exceeds a critical value which depends on the slope. This critical slope depends on the altitude and aspect regardless of soil thickness. A temporal analysis carried out by tree-ring counting demonstrated that the occurrence of these movements is not random though there are some periods of higher hazard, the probable triggering mechanisms being heavy snowfalls or earthquakes.

Gallart, Francesc; Clotet-Perarnau, Núria; Bianciotto, Oscar; Puigdefàbregas, Joan

1994-05-01

221

Análisis del espectro infrarrojo del polvo interestelar asociado con cúmulos globulares y de su evolución temporal  

NASA Astrophysics Data System (ADS)

El trabajo que se presenta investiga la dinámica de las partículas de polvo interestelar eyectadas por estrellas gigantes rojas en un cúmulo globular utilizando simulaciones numéricas de su interacción con el campo gravitatorio y con la radiación electromagnética de las estrellas. Se pretende con ello determinar la distribución espacial de ese material como una función del tiempo en un sistema similar a NGC 104 (47 Tuc). A partir de la distribución espacial resultante se obtuvo el espectro infrarrojo integrado el cual sugiere que el máximo contraste con la radiación estelar ocurre en longitudes de onda cercanas a 300 ?m y que decrece rápidamente hacia longitudes de onda menores, en las que suelen realizarse las observaciones.

Pellizza, L. J.; Forte, J. C.; Carpintero, D.

222

El diseño final del espectrógrafo de banco (EBASIM) para CASLEO  

NASA Astrophysics Data System (ADS)

Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

Simmons, J.; Levato, H.

223

EFECTO GENOTÓxICO DEL DICROMATO DE POTASIO EN ERITROCITOS DE SANGRE PERIFéRICA DE Oreochromis niloticus (TILAPIA)  

Microsoft Academic Search

RESUMEN Existen múltiples reportes del efecto genotóxico y cancerígeno del cromo VI, los seres humanos tenemos una permanente exposición a este elemento. Objetivos. Evidencias la genotoxicidad del dicromato de potasio utilizando como sistema biológico a Oreochromis niloticus \\

Zulita Prieto; Julio León-Incio; Carlos Quijano-Jara; Radigud Fernández; Edgardo Polo-Benites; Roger Vallejo-Rodríguez; Luis Villegas-Sanchez

224

Field measurements of del13C in ecosystem respiration  

NASA Astrophysics Data System (ADS)

Stable carbon isotope del13C-measurements are extensively used to study ecological and biogeochemical processes in ecosystems. Above terrestrial ecosystems, atmospheric del13C can vary largely due to photosynthetic fractionation. Photosynthetic processes prefer the uptake of the lighter isotope 12C (in CO2), thereby enriching the atmosphere in 13C and depleting the ecosystem carbon. At night, when ecosystem respiratory fluxes are dominant, 13C-depleted CO2 is respired and thereby depletes the atmospheric del13C-content. Different ecosystems and different parts of one ecosystem (type of plant, leaves, and roots) fractionate and respire with a different del13C-ratio signature. By determining the del13C-signature of ecosystem respiration in temporal and spatial scale, an analysis can be made of the composition of respiratory sources of the ecosystem. A field study at a dry cropland after harvest (province of Viterbo, Lazio, Italy) was performed in the summer of 2013. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure CO2-, CH4-, N2O-, CO- and del13C-concentrations. The FTIR was connected to 2 different flux measurements systems: a Flux Gradient system (sampling every half hour at 1.3m and 4.2m) and 2 flux chambers (measured every hour), providing a continuous data set of the biosphere-atmosphere gas fluxes and of the gas concentrations at different heights. Keeling plot intercept values of respiratory CO2, measured by the Flux Gradient system at night, were determined to be between -25‰ and -20‰. Keeling plot intercept values of respiratory CO2, measured by the flux chamber system, varied between -24‰ and -29‰, and showed a clear diurnal pattern, suggesting different (dominant) respiratory processes between day and night.

van Asperen, Hella; Sabbatini, Simone; Nicolini, Giacomo; Warneke, Thorsten; Papale, Dario; Notholt, Justus

2014-05-01

225

Applied clinical pharmacology and public health in rural Asia - preventing deaths from organophosphorus pesticide and yellow oleander poisoning  

PubMed Central

Self-poisoning with pesticides or plants is a major clinical problem in rural Asia, killing several hundred thousand people every year. Over the last 17 years, our clinical toxicology and pharmacology group has carried out clinical studies in the North Central Province of Sri Lanka to improve treatment and reduce deaths. Studies have looked at the effectiveness of anti-digoxin Fab in cardiac glycoside plant poisoning, multiple dose activated charcoal in all poisoning, and pralidoxime in moderate toxicity organophosphorus insecticide poisoning. More recently, using a Haddon matrix as a guide, we have started conducting public health and animal studies to find strategies that may work outside of the hospital. Based on the 2009 GSK Research in Clinical Pharmacology prize lecture, this review shows the evolution of the group's research from a clinical pharmacology approach to one that studies possible interventions at multiple levels, including the patient, the community and government legislation.

Eddleston, Michael

2013-01-01

226

The Oleander Project: Monitoring the Variability of the Gulf Stream and Adjacent Waters between New Jersey and Bermuda.  

NASA Astrophysics Data System (ADS)

An overview of the first 4.5 years of operation of a program to monitor the structure and variability of the Gulf Stream (GS) is presented. A container vessel that operates on a weekly schedule between Port Elizabeth, New Jersey, and Hamilton, Bermuda, is equipped with a 150-kHz narrowband acoustic Doppler current profiler to measure currents from the surface to 300 m depth. A major objective of the multiyear program is to study the annual cycle and interannual variations in velocity structure and transport by the GS. In this survey the focus is on the transport and lateral structure of the current at 52-m depth.The velocity maximum is constant at 2.07 ± 0.24 m s1 (4 kt) with a seasonal range of 0.1 m s1. Seasonal and interannual variations in total transport are observed but appear to be limited to the edges of the current, apparently reflecting low-frequency variations in the intensity of the recirculating waters adjacent to the stream. The transport by the central core of the current, defined as those waters moving at 1 m s1 or faster, equals 0.9 ×180; 105 m2 s1, has no seasonal signal, and is constant to within a few percent when averaged in half-year intervals. If the central core of the current is viewed as "insolated" from the effects of meandering, this result implies substantial stability to the large-scale wind-driven and thermohaline circulations during the observation program. Variations in poleward heat transport probably originate less in the GS and more from changing heat loss patterns at higher latitudes.Other issues concerning the potential vorticity field and energy conversion rates are also discussed. This ongoing program illustrates the role commercially operated vessels can play in making repeat observations of the velocity structure (and other parameters) of the ocean on a regular basis.

Rossby, T.; Gottlieb, E.

1998-01-01

227

El doctor Varmus dirigirá una institución "inigualable", afirma el director del NCI, doctor John Niederhuber  

Cancer.gov

En un mensaje dirigido al personal del Instituto Nacional del Cáncer (NCI) y a quienes se interesan por la oncología, el doctor John Niederhuber, director del NCI, aplaude el nombramiento de Harold Varmus y afirma que esta designación le "dará al NCI un liderazgo fuerte no solo en la institución sino mas allá de ella, así como una voz muy respetada en el Congreso, que abogue por los recursos que son tan necesarios para sostener la misión del Instituto.

228

Net'aa chonaarãweda nepiripata p’edaa = Tradición oral del pueblo épera  

Microsoft Academic Search

La presencia épera en el Ecuador se remonta a principios de los años sesenta del siglo pasado, cuando pequeñas olas migratorias de indígenas colombianos del Saija llegaron a Ecuador y se asentaron en la región noroccidental de la provincia de Esmeraldas en la costa del Pacífico. Algunas razones para la migración fueron el comercio y la similitud entre su medio

J. Gómez Rendón; W. Poirama; L. Quiroz; B. Chiripua; Y. Capena

2008-01-01

229

Política monetaria y cambios de régimen en los tipos de interés del mercado interbancario español  

Microsoft Academic Search

En este trabajo analizamos el comportamiento dinámico del tipo de interés a un mes del mercado interbancario español entre 1987 y 2001. Se utiliza un proceso de difusión tipo raíz cuadrada que permite que el tipo cambie dependiendo del estado de la economía. El cambio entre regímenes es dirigido por un proceso de Markov de primer orden con probabilidades de

José Luis Fernández-Serrano; M. Dolores Robles Fernández

2004-01-01

230

Política Monetaria y Cambios de Régimen en los tipos de Interés del Mercado Interbancario  

Microsoft Academic Search

En este trabajo analizamos el comportamiento dinámico del tipo de interés a un mes del mercado interbancario español entre 1987 y 2001. Se utiliza un proceso de difusión tipo raíz cuadrada que permite que el tipo cambie dependiendo del estado en el que se encuentre la economía. El cambio entre regímenes es dirigido por un proceso de Markov de primer

José Luis Fernández Serrano; Dolores Robles Fernández

2002-01-01

231

Estudio Hidrológico del río Arlanzón a su paso por el Término Municipal de Burgos  

Microsoft Academic Search

Para la ordenación del territorio en el Término Municipal de Burgos se necesita conocer el riesgo de inundación por las aguas de los ríos Arlanzón, Vena, Cardeñadijo y Ubierna. Por ello, se ha realizado un estudio hidrológico de la cuenca del Arlanzón partiendo de los datos de precipitaciones, cartografía referente a usos del suelo, edafología, geología y topografía, fotografías aéreas

Iñigo OLEAGORDIA MONTAÑA; Rebeca RODRÍGUEZ GARCÍA; Joaquín NAVARRO HEVIA; CASTILLO NOVO

232

ESTUDIO MESOMECÁNICO DE LA FRACTURA DEL HORMIGÓN PARA DIFERENTES VELOCIDADES DE CARGA  

Microsoft Academic Search

Resumen. En este artículo se analiza el comportamiento del hormigón a un nivel mesomecánico de observación bajo cargas de tracción uniaxial dependientes del tiempo. Como punto de partida se ha empleado un modelo mesoestructural en 2D para materiales heterogéneos basado en elementos junta de espesor nulo, desarrollado dentro del grupo de investigación de la ETSECCPB-UPC. En este modelo, la estructura

Ricardo Lorefice; Guillermo Etse; Carlos M. López; Ignacio Carol

233

Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

Ford-Guerrera, Rebecca

234

Regulaciones del mercado laboral: un estudio comparativo entre países  

Microsoft Academic Search

En este trabajo se analizan tres tipos de instituciones prevalecientes en los mercados laborales de muchos países, normas sobre salario mínimo, introducción de costos no salariales (prestaciones complementarias) y las políticas de salario y empleo del gobierno. Se sostiene que estos tres son los aspectos estratégicos a analizar en el caso de los países en desarrollo con respecto a las

Peter R. Fallon; Luis Riveros

235

Estimación endógena del repudio en mercados soberanos de crédito  

Microsoft Academic Search

En vista de la falta de fundamentos teóricos en la bibliografía relacionada con el repudio en los mercados soberanos de crédito, se construye un modelo que considera todas las peculiaridades de los mercados internacionales de crédito. En particular, se incluye la idea de sanciones en el caso de repudio. Del modelo se extraen diversas conclusiones que contrastan con lo existente.

Fausto Hernández Trillo

1994-01-01

236

Del Mod: A State-Wide System for School Improvement.  

ERIC Educational Resources Information Center

This is a retrospective account of the Del Mod System, a statewide project to improve science and mathematics education in the elementary and secondary schools of Delaware. The project functioned from 1970-76 under the auspices of a committee including the presidents of institutions of higher education, the state superintendent of public…

Neale, Daniel C.

237

Advances in optical technologies at Pontificia Universidad Católica del Perú  

NASA Astrophysics Data System (ADS)

In this work, it is shown a panoramically view of advances and works on fundamental optical technology developed and Physics Section at Pontificia Universidad Católica del Perú PUCP in Lima Peru. This includes works in, precision optics manufacturing, optical testing, and optical design and simulation and also in optical thin film evaporation and its design techniques

Baldwin, Guillermo; Asmad, Miguel; Romero, Sandra; Gonzales, Franco; Gálvez, Gonzalo; Sánchez, Rubén; Córdova, Darwin

2011-05-01

238

Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer

2008-01-01

239

Medical Ethnobotany of the Teribes of Bocas del Toro, Panama  

Microsoft Academic Search

Ethnomedical uses of 108 medicinal plant species, belonging to 52 families, 89 genera, used by the Teribe Amerindians of Bocas del Toro Province in Panama, along with their socio-cultural practices are reported here. The methods of administration of the herbal remedies, the plant parts used, their families and local names are also documented. The recorded medicinal plants were used mainly

M. P. Gupta; P. N. Solís; A. I. Calderón; F. Guinneau-Sinclair; M. Correa; C. Galdames; C. Guerra; A. Espinosa; G. I. Alvenda; G. Robles; R. Ocampo

2005-01-01

240

Aspetti evolutivi del sistema agro-alimentare in Algeria  

Microsoft Academic Search

Aspetti evolutivi del sistema agro-alimentare in Algeria (di Antonio Guariglia) - ABSTRACT: Even if it’s estimated that Algeria has potentially around 39 millions hectares of cultivable grounds, at present, the SAU is estimated equal to only 8 millions hectares (3% of territorial surface) situated in the almost totality along the fruitful and narrow coastal plan, while around 31 thousand hectares

Antonio Guariglia

2000-01-01

241

Regional geoid determination in Tierra del Fuego including GPS levelling  

Microsoft Academic Search

A regional geoid model for the Argentine part of the Isla Grande de Tierra del Fuego, established in previous works on the basis of GPS levelling, suffers a lack of observation data in the remote south-western investigation area. In order to improve the data distribution in this region, the mean lake level of Lago Fagnano has been regarded as a

Daniel del Cogliano; Reinhard Dietrich; Andreas Richter; Raúl Perdomo; José Luis Hormaechea; Gunter Liebsch; Mathias Fritsche

2007-01-01

242

Geological and Geophysical Investigations at Sierra del Medio Massif - Argentine.  

National Technical Information Service (NTIS)

Geological investigations were performed at Sierra del Medio (Chubut Province), a mountainous massif of about 25 km by 8 km of migmatic origin, which emerges from a depressed tectonic trench or graben called Pampa de Gastre. The most ancient rocks belong ...

J. C. Perucca E. Llambias H. H. Puigdomenech E. Cebrelli C. E. Castro

1987-01-01

243

The mercury clock of the Libros del Saber  

Microsoft Academic Search

The Libros del Saber de Astronomia is a compilation of various Arabic astronomical works translated into Castilian in the second half of the thirteenth century, under the direction of King Alfonso X of Spain. A section describing a mercury clock has been suggested to be of particular significance in view of the likely invention of the mechanical clock around this

A. A. Mills

1988-01-01

244

Políticas Española e Italiana según la Directiva Marco del Agua  

Microsoft Academic Search

RESUMEN Se ha elaborado un análisis de la evolución de la política internacional y europea, en relación a la gestión de los recursos hídricos, para identificar y comparar principios, objetivos y métodos de actuación en dos países mediterráneos miembros de la Unión Europea: Italia y España. La comparativa obtenida se hace tomando como referencia esencial la Directiva Marco del Agua,

Luis Miguel Valenzuela Montes; Anna Rigossi

2009-01-01

245

MATEMÁTICAS Y ORDENADORES EN EL CONOCIMIENTO DEL MUNDO  

Microsoft Academic Search

espacios abstractos, llamados hoy espacios de Hilbert, sería la base ,matemática de la ,Mecánica Cuántica. Esta situación contrasta con la del siglo XVII, en que Newton se vió obligado a desarrollar por sí mismo el cálculo diferencial para hacer convincentes las conclu- siones de los Principia, en tanto que a Hilbert le parecía que esfuerzos de este ,tipo ya no

M ANUEL L ÓPEZ; P ELLICER

246

L' IMPOLLINAZIONE DEL MIRTILLO GIGANTE AMERICANO (VACCINIUM CORYMBOSUM L.)  

Microsoft Academic Search

Nella fascia montana della nostra Regione la coltivazione delle specie frutticole minori è stata introdotta negli anni '80 come atti- vità agricola alternativa per diversificare le produzioni e come possibile integrazione al reddito per le aree marginali. Tra le diverse specie coltivate si annovera anche il mirtillo gigante (Vaccinium corymbosum L.). I fiori del mirtillo, di forma urceola- ta, sono

D. Prodorutti; F. Frilli; P. A. Belletti

247

Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.  

ERIC Educational Resources Information Center

An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

Karadima, Oscar

248

Se lanza Red Nacional de Estudios Clínicos del NCI  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

249

Cosmogenic Radionuclides in the Campo Del Cielo Iron Meteorite  

NASA Technical Reports Server (NTRS)

Cosmogenic Be-10, Al-26, Cl-36, Ca-41, and Ni-59 were measured in the Campo del Cielo iron meteorite. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented. Additional information is contained in the original extended abstract.

Liberman, R. G.; FernandezNiello, J. O.; Reedy, R. C.; Fifield, L. K.; diTada, M. L.

2001-01-01

250

Efecto del Programa de Entrenamiento "Manejo del Dolor" en la Documentaci?n de Enfermer?a en el Expediente Electr?nico  

PubMed Central

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones.

Monsivais, Maria Guadalupe Moreno; Guzman, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vazquez

2012-01-01

251

Molecular and cytogenetic characterization of del(9p) syndrome  

SciTech Connect

The del(9p) syndrome is characterized by mental retardation, trigonocephaly, midface hypoplasia, upward slanting palpebral fissures, a long philtrum, and is typically associated with a breakpoint at 9p22. Seventeen unrelated patients with del(9p) and their parents were analyzed by high resolution chromosome studies, molecular analysis using a series of highly polymorphic dinucleotide repeat markers for 9p, and fluorescence in situ hybridization (FISH) to characterize precisely the extent of chromosome loss. Eleven patients were found to have an interstitial deletion with breakpoints assigned to 9p22.1 and 9p24.3 in most cases. Two patients had familial unbalanced translocations of maternal origin and four had de novo complex rearrangements identified by high resolution analysis and FISH utilizing chromosome libraries. PCR analysis of eleven families with eight minisatellite markers determined paternal origin of the deletion in six cases and maternal origin in five. This suggests that the molecular event resulting in the deletion is equally prevalent in both male and female gametogenesis and that genomic imprinting does not play a role in the pathogenesis of del(9p) syndrome. Increased precision in mapping these minisatellite markers was also possible through this work. This study demonstrates the existence of molecular heterogeneity as six patients with a cytological breakpoint at 9p22.1 revealed three different molecular breakpoints. These findings suggest that genotype-phenotype correlations in deletion syndromes such as this should be based on high-resolution molecular analysis of the deleted chromosome segment. Work is in progress to map a series of cosmid probes by FISH relative to chromosomal breakpoints in these patients. These combined studies should provide a better understanding of the mechanisms involved in the pathogenesis of del(9p) syndrome and may identify loci where genes responsible for one or more aspects of the del(9p) phenotype may reside.

Micale, M.A.; Haren, J.M.; Schwartz, S. [Case Western Reserve Univ. School of Medicine, Cleveland, OH (United States)] [and others

1994-09-01

252

Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.  

NASA Astrophysics Data System (ADS)

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 ?m, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Muñoz-Caro, Guillermo Manuel

253

LA CONSOLIDACIÓN DEL HAMBRE Y DEL DERECHO A LA ALIMENTACIÓN EN LAS AGENDAS POLÍTICAS DE AMÉRICA LATINA  

Microsoft Academic Search

América Latina y el Caribe es la única región en desarrollo que puede acabar con el hambre en nuestra generación. Tiene 52,4 millones de personas subnutridas (10% de población) y 9 millones de niños con desnutrición crónica, pero también es la principal productora mundial de alimentos y tiene recursos financieros, naturales, humanos e institucionales para hacer del hambre un recuerdo

Jose Luis Viveros; Niemeyer Almeida Filho

2008-01-01

254

La democracia constitucional en América Latina y las evoluciones recientes del presidencialismo. Memorias Encuentro del Instituto Iberoamericano de Derecho Constitucional  

Microsoft Academic Search

Siempre será oportuno reflexionar sobre la democracia, su contenido, sus desafíos, su presente y su futuro, las transformaciones y percepciones que de ella se tienen. No son pocas las preocupaciones o inquietudes que la democracia suscita en esta parte del mundo, y muestra de ello son los más variados estudios e informes sobre el estado actual de la democracia y

Pedro Pablo Vanegas

255

Prognostic Impact of del(17p) and del(22q) as Assessed by Interphase FISH in Sporadic Colorectal Carcinomas  

PubMed Central

Background Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. Methodology/Principal Findings We prospectively analyzed the frequency of numerical/structural abnormalities of chromosomes 1, 7, 8, 13, 14, 17, 18, 20, and 22 by iFISH in 58 sCRC patients: thirty-one non-metastatic (54%) vs. 27 metastatic (46%) disease. From a total of 18 probes, significant differences emerged only for the 17p11.2 and 22q11.2 chromosomal regions. Patients with liver metastatic sCRC showed an increased frequency of del(17p11.2) (10% vs. 67%;p<.001) and del(22q11.2) (0% vs. 22%;p?=?.02) versusnon-metastatic cases. Multivariate analysis of prognostic factors for overall survival (OS) showed that the only clinical and cytogenetic parameters that had an independent adverse impact on patient outcome were the presence of del(17p) with a 17p11.2 breakpoint and del(22q11.2). Based on these two cytogenetic variables, patients were classified into three groups: low- (no adverse features), intermediate- (one adverse feature) and high-risk (two adverse features)- with significantly different OS rates at 5-years (p<.001): 92%, 53% and 0%, respectively. Conclusions/Significance Our results unravel the potential implication of del(17p11.2) in sCRC patients with liver metastasis as this cytogenetic alteration appears to be intrinsically related to an increased metastatic potential and a poor outcome, providing additional prognostic information to that associated with other cytogenetic alterations such as del(22q11.2). Additional prospective studies in larger series of patients would be required to confirm the clinical utility of the new prognostic markers identified.

Gonzalez-Gonzalez, Maria; Munoz-Bellvis, Luis; Mackintosh, Carlos; Fontanillo, Celia; Gutierrez, M. Laura; Abad, M. Mar; Bengoechea, Oscar; Teodosio, Cristina; Fonseca, Emilio; Fuentes, Manuel; De Las Rivas, Javier

2012-01-01

256

Fair trade, premio di prezzo e fallimenti del mercato  

Microsoft Academic Search

Il premio di prezzo è solo una componente, non marginale, sicuramente la più caratteristica e facilmente comunicabile, ma certamente non decisiva nel modello Fair Trade. L’avere incentrato l’attenzione su questo specifico aspetto del meccanismo complessivo ha nascosto altri aspetti più rilevanti dello schema operativo. Nel presente lavoro si cerca di mostrare come l’impatto maggiore delle strategie di Fair Trade riguarda

A. Arrighetti

2007-01-01

257

The Borexino detector at the Laboratori Nazionali del Gran Sasso  

Microsoft Academic Search

Borexino, a large volume detector for low energy neutrino spectroscopy, is currently running underground at the Laboratori Nazionali del Gran Sasso, Italy. The main goal of the experiment is the real-time measurement of sub-MeV solar neutrinos, and particularly of the monoenergetic (862keV) 7Be electron capture neutrinos, via neutrino–electron scattering in an ultra-pure liquid scintillator. This paper is mostly devoted to

G. Alimonti; C. Arpesella; H. Back; M. Balata; D. Bartolomei; A. de Bellefon; G. Bellini; J. Benziger; A. Bevilacqua; D. Bondi; S. Bonetti; A. Brigatti; B. Caccianiga; L. Cadonati; F. Calaprice; C. Carraro; G. Cecchet; R. Cereseto; A. Chavarria; M. Chen; A. Chepurnov; W. Czech; D. D’Angelo; F. Dalnoki-Veress; A. De Bari; E. De Haas; A. Derbin; M. Deutsch; A. Di Credico; A. Di Ludovico; G. Di Pietro; R. Eisenstein; F. Elisei; A. Etenko; F. von Feilitzsch; R. Fernholz; K. Fomenko; R. Ford; D. Franco; B. Freudiger; N. Gaertner; C. Galbiati; F. Gatti; S. Gazzana; V. Gehman; M. Giammarchi; D. Giugni; M. Goeger-Neff; T. Goldbrunner; A. Golubchikov; C. Grieb; C. Hagner; T. Hagner; W. Hampel; E. Harding; S. Hardy; F. X. Hartmann; R. von Hentig; T. Hertrich; G. Heusser; M. Hult; A. Ianni; An. Ianni; L. Ioannucci; K. Jaenner; M. Joyce; H. de Kerret; S. Kidner; J. Kiko; T. Kirsten; V. Kobychev; G. Korga; G. Korschinek; Yu. Kozlov; D. Kryn; P. La Marche; V. Lagomarsino; M. Laubenstein; C. Lendvai; M. Leung; T. Lewke; E. Litvinovich; B. Loer; F. Loeser; P. Lombardi; L. Ludhova; I. Machulin; S. Malvezzi; A. Manco; J. Maneira; W. Maneschg; I. Manno; D. Manuzio; G. Manuzio; M. Marchelli; A. Martemianov; F. Masetti; U. Mazzucato; K. McCarty; D. McKinsey; Q. Meindl; E. Meroni; L. Miramonti; M. Misiaszek; D. Montanari; M. E. Monzani; V. Muratova; P. Musico; H. Neder; A. Nelson; L. Niedermeier; S. Nisi; L. Oberauer; M. Obolensky; M. Obolensky; F. Ortica; M. Pallavicini; L. Papp; R. Parcells; S. Parmeggiano; M. Parodi; N. Pelliccia; L. Perasso; A. Pocar; R. Raghavan; G. Ranucci; W. Rau; A. Razeto; E. Resconi; P. Risso; A. Romani; D. Rountree; A. Sabelnikov; P. Saggese; R. Saldhana; C. Salvo; R. Scardaoni; D. Schimizzi; S. Schönert; K. H. Schubeck; T. Shutt; F. Siccardi; H. Simgen; M. Skorokhvatov; O. Smirnov; A. Sonnenschein; F. Soricelli; A. Sotnikov; S. Sukhotin; C. Sule; Y. Suvorov; V. Tarasenkov; R. Tartaglia; G. Testera; D. Vignaud; S. Vitale; R. B. Vogelaar; V. Vyrodov; B. Williams; M. Wojcik; R. Wordel; M. Wurm; O. Zaimidoroga; S. Zavatarelli; G. Zuzel

2009-01-01

258

Paradigmas de verbos en el zapoteco del istmo  

Microsoft Academic Search

Varios an?lisis se han hecho o pueden hacerse de las conjugaciones de los verbos en el zapoteco, una familia de lenguas de Oaxaca, M?xico. Marlett y Pickett 1987, siguiendo el an?lisis de Speck 1984, proponen uno para el zapoteco del istmo que hace referencia a un an?lisis de la estructura sil?bica de la lengua. Pickett 1967 presenta otro. Un desaf?o

Isthmus Zapotec; Verb Paradigms

259

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

260

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

261

Solar adaptive optics at the Observatorio del Teide, Tenerife  

NASA Astrophysics Data System (ADS)

Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

2013-10-01

262

Nuevo sitio web en español del Instituto Nacional del Cáncer, (NCI, por sus siglas en inglés) Cancer.gov en español - Silvia Inéz Salazar - transcript  

Cancer.gov

Transmisiones de radio para promover Cancer.gov en espa%XF1ol | Nuevo sitio web en espa%XF1ol del Instituto Nacional del C%XE1ncer, (NCI, por sus siglas en ingl%XE9s) Cancer.gov en espa%XF1ol | Transcripci%XF3n Transmisiones de radio para promover

263

Un gobierno alternativo en una región olvidada de Colombia: entrevista al taita Floro Alberto Tunubalái Paja, gobernador del departamento del Cauca  

Microsoft Academic Search

El Departamento del Cauca está situado al Sur de Colombia. En los últimos años ha ocupado el penúltimo lugar en su aporte económico al país. Lós índices de pobreza son grandes, la oferta de trabajo es baja y la desatención y disminución del Estado se acentúa, haciendo cada vez más dificil la solución de las desigualdades sociales que vive la

Diego Jaramillo Salgado

2001-01-01

264

Correction: First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an error in transcription, the distance is given incorrectly in the text of ATel#5409. Along with the typo "Space Telescope Imaging Spectrograph", the text should read: Comparing these STIS UV spectra with high resolution IUE spectra of the CO nova OS And 1986 obtained between 12 days (LWP) and 22 days (SWP) after optical discovery (1986 Dec. 17, 27 respectively) shows a very close agreement such that when independently dereddened, the ratio of V339 Del to OS And between 1200 and 1900A is ~1.5 in flux (similar in the 2000-3000A range but more uncertain because of the earlier date of the long wavelength IUE observation), indicating that the distance to V339 Del is about 4.2 kpc (distance to OS And ~ 5.1 kpc with E(B-V)=0.25+/-0.05, see Schwarz et al.

Shore, S. N.

2013-09-01

265

The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma coming from a reservoir located approximately at a depth of approximately 8 km and accumulating in shallow reservoir less than 2 km beneath the main crater. We fit the data with both a spherical and a vertical spheroid source. The spherical source indicates the existence of an intrusion at a depth of 1823±1056 m with a volume change of (7±17)×106 m3 . The vertical spheroidal source suggests a source 1855 m deep with a volume change of 6×106 m3 . These results imply that while we have strong bounds on the depth of the intrusion, the actual volume of the source is less certain. Gas emission from Nevado del Ruiz volcano in April 7, 2012.

Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.

2012-12-01

266

Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma  

PubMed Central

Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most of the studies have targeted the TP53 gene for deletion analyses, although no study showed that this gene is the deletion target. In order to address this issue, we sequenced the TP53 gene in 92 patients with multiple myeloma at diagnosis, 54 with a del(17p) and 38 lacking del(17p). At least one mutation was found in 20 patients, all of them presenting a del(17p). The analysis of the mutation location showed that virtually all of them occurred in highly conserved domains involved in the DNA-protein interactions. In conclusion, we showed that 37% of the myeloma patients with del(17p) present a TP53 mutation versus 0% in patients lacking the del(17p). The prognostic significance of these mutations remains to be evaluated.

Lode, Laurence; Eveillard, Marion; Trichet, Valerie; Soussi, Thierry; Wuilleme, Soraya; Richebourg, Steven; Magrangeas, Florence; Ifrah, Norbert; Campion, Loic; Traulle, Catherine; Guilhot, Francois; Caillot, Denis; Marit, Gerald; Mathiot, Claire; Facon, Thierry; Attal, Michel; Harousseau, Jean-Luc; Moreau, Philippe; Minvielle, Stephane; Avet-Loiseau, Herve

2010-01-01

267

VEGF: A modifier of the del22q11 (DiGeorge) syndrome?  

Microsoft Academic Search

Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Here, we report that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11

Ingeborg Stalmans; Diether Lambrechts; Frederik De smet; Sandra Jansen; Jian Wang; Sunit Maity; Paige Kneer; Maren von der Ohe; Ann Swillen; Christa Maes; Marc Gewillig; Daniel G. M. Molin; Peter Hellings; Thurid Boetel; Maartin Haardt; Veerle Compernolle; Mieke Dewerchin; Stephane Plaisance; Robert Vlietinck; Beverly Emanuel; Adriana C. Gittenberger-de Groot; Peter Scambler; Bernice Morrow; Deborah A. Driscol; Lieve Moons; Camila V. Esguerra; Geert Carmeliet; Annett Behn-Krappa; Koen Devriendt; Désiré Collen; Simon J. Conway; Peter Carmeliet

2003-01-01

268

Efectos derivados de la puesta en pr ctica del marketing de relaciones en los servicios profesionales  

Microsoft Academic Search

El objetivo del presente trabajo es identificar la influencia sobre el consumidor y sobre el resultado empresarial de dos dimensiones b sicas de los servicios profesionales: la dimensi¢n formal o calidad del servicio prestado y la dimensi¢n informal o interacci¢n personal con el cliente. Sobre la base te¢rica del marketing de relaciones, se analiza c¢mo influyen los aspectos formales e

Paolo Freire de Carvalho Filho; Carmen Camarero Izquierdo

2003-01-01

269

Use of Real Time PCR for Rapid Detection of Del Phenotype in Taiwan  

Microsoft Academic Search

During routine serologic procedures, Rh Del blood is often not identified and subsequently labeled as RhD-negative. Recently, several reports have shown the ability of Del blood to induce anti-D in RhD-negative recipients. Among Korean, Japanese, and Chinese, almost all individuals with Del blood have a nucleotide change in the RHD gene of 1227G>A (RHDK407K). Thus, nucleotide 1227A at RHD exon

Chien-Feng Sun; Jui-Ping Liu; Ding-Ping Chen; Wei-Ting Wang; Tyng-Tyng Yang

270

Els Fragments del Sacramentari de Sant Boi de Lluçanès (Vic. Bib. Espisc., Frag I\\/6)  

Microsoft Academic Search

Els disset folis del manuscrit Vic, Bib. Episc., frag. I\\/6 són les restes d'un sacramentari de tipus gregorià mixt, procedents de la parròquia de Sant Boi de Lluçanès. Foren escrites en l'últim quart del segle X, però, al segon quart del segle XII s'hi feren esmenes adaptant el seu cànon als models d'aquest segle. En això rau la seva singularitat.

Miquel dels Sants Gros i Pujol

2005-01-01

271

Distribución del continuo ultravioleta e infrarrojo en estrellas Be  

NASA Astrophysics Data System (ADS)

Estamos interesados en interpretar los excesos de flujo infrarrojo y/o ultravioleta observados en estrellas Be con respecto al de estrellas B normales, así como su posible correlación. Una envoltura rodeando la estrella distingue una estrella Be de una B normal; para explicar las observaciones es necesario entonces tener en cuenta todos los posibles procesos físicos que en ella tienen lugar. Adoptando un modelo atmosférico específico, hemos estudiado el proceso de recombinación dielectrónica de metales como MgII y FeII, teniendo en cuenta la posible influencia de la opacidad del medio en el flujo emitido.

Cruzado, A.; Ringuelet, A.; di Rocco, H.

272

Variabilidad del metabolismo oxidativo de fármacos en la población uruguaya Polimorfismo genético del citocromo P-450 2D6  

Microsoft Academic Search

Resumen El estudio ele losj¿7ctores gméticos que determirmr7 la respuesta a los 7~2edictr7i2erzfo.s se demmirm ,fi77.7rlacogerrética. EH la década del 70 se describió el polirnorfïsmo perr&ico dc Iri Llchri.coqLrina-hidroxiiasa. u77 hallazgo de gran r-elevatrcia dado que rnlrclîo.r.f¿í~\\/llcrc,o.c utili:ados cu terapéutica se oxidar? por la misma \\\\jía metahólic~a. Esto e.xpliccr ,grrrrr parte LIP iir var-iahilitiud iudividual que se obset-va en las

Francisco E. Estévez; Marcos Giusti; Susana Parrillo; Miguel Pr-ando

1997-01-01

273

Aparición del cometa Hale - BOPP C / 1995-01  

NASA Astrophysics Data System (ADS)

El Cometa Hale - Bopp fue observado a partir de la 10ma. magnitud con el telescopio de 300mm de abertura a f/6.5. En esas primeras observaciones desde luego no hubo mucho detalle. A su vez las posiciones del cometa para nuestro hemisferio no fueron favorables, solamente asomó por el horizonte N.O. para nuestra latitud cuando se alejaba de la Tierra. Se registró la observación visualmente con binoculares 10 x 50, y fotográficamente con un Telezoom de 210mm a f/4,5 con película 400 ASA color. Todas las imágenes fueron procesadas y digitalizadas a fin de obtener las diferentes escalas de brillo. El aspecto que presentó para nuestra posición geográfica fue discreta ya que tuvo su máximo brillo cuando era visible desde el hemisferio norte. Presentó la clásica cola de polvo curva, y con su aspecto casi estelar, destacándose entre la luminosidad del crepúsculo. Instrumentos Utilizados: Telezoom de 210mm a f/4.5, Telescopio refractor de 80mm a f/15, Binocular 10 x 50

Arquiola, A.

274

Deadly Lahars from Nevado del Ruiz, Colombia: November 13, 1985  

NSDL National Science Digital Library

This web site describes a series of Lahars that occurred from the Nevado del Ruiz volcano in the Andes mountains, the northernmost and highest volcano in Colombia. Beginning in November 1984, the volcano began showing clear signs of unrest. An explosive eruption from Ruiz's summit crater on November 13, 1985, at 9:08 p.m. generated an eruption column and sent a series of pyroclastic flows and surges across the volcano's summit. Within minutes, pumice and ash began to fall to the northeast along with heavy rain that had started earlier in the day. Within four hours, lahars had traveled 100 km and left behind a wake of destruction: more than 23,000 people killed, about 5,000 injured, and more than 5,000 homes destroyed along the Chinchina, Guali, and Lagunillas rivers and destroying the town of Armero, Columbia. This deadly eruption of Nevado del Ruiz offers lessons on the generation of lahars for scientists, emergency-response professionals, and communities located downstream of such ice- and snow-covered volcanoes. The narrative is illustrated with 9 photographs.

Banks, N.; Marso, J.; Pierson, T.; Janda, R.

275

Descubrimiento del primer yacimiento cuaternario (Riss-Wiirm) de vertebrados con restos humanos en la provincia de Madrid (Pinilla del Valle)  

Microsoft Academic Search

We give notice of a new fossiliferous loeality with vertebrate rests of Pleistocene age, placed in Pinilla del Valle (Madrid). It is made up by quaternary sediments filling a ca)careous fallen shelter.

E. ALFÉREZ; G. MOLERO; E. MALDONADO; P. BREA; A. IV

276

Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis  

Microsoft Academic Search

The mutation F508del is the commonest cause of the genetic disease cystic fibrosis (CF). CF disrupts the function of many organs in the body, most notably the lungs, by perturbing salt and water transport across epithelial surfaces. F508del causes harm in two principal ways. First, the mutation prevents delivery of the cystic fibrosis transmembrane conductance regulator (CFTR) to its correct

Zhi-wei Cai; Jia Liu; Hong-yu Li; David N Sheppard

2011-01-01

277

Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

Microsoft Academic Search

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

S. J. Landau; P. D. Sisterna; H. Vucetich

2003-01-01

278

Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

NASA Astrophysics Data System (ADS)

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

Landau, S. J.; Sisterna, P. D.; Vucetich, H.

279

El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer  

Cancer.gov

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.

280

Vertebrates of the El Pelillal locality (Campanian, Cerro Del Pueblo Formation), southeastern Coahuila, Mexico  

Microsoft Academic Search

A new locality named El Pelillal (Cerro del Pueblo Formation, Late Cretaceous, Campanian) in the southeastern area of the State of Coahuila, México yields an assemblage of vertebrates that is important for correlation due to its frequent occurrence in other localities along the Cerro del Pueblo Formation outcrops. It is located in the Municipio de Ramos Arizpe, Coahuila. Among the

Ruben A. Rodriguez-De La Rosa; Sergio R. S. Cevallos-Ferriz

1998-01-01

281

Screening of antibacterial activity of Amaicha del Valle (Tucumán, Argentina) propolis  

Microsoft Academic Search

Propolis is extensively used in Argentine folk medicine. Alcoholic extracts of propolis from four localities of Amaicha del Valle (El Paraiso, La Banda Este, La Banda Oeste and El Molino), Province of Tucumán and from Cerrillos, Province of Santiago del Estero, Argentina were prepared. All showed antibacterial activity against Gram positive bacteria, the propolis from La Banda Este being the

M. I. Nieva Moreno; M. I. Isla; N. G. Cudmani; M. A. Vattuone; A. R. Sampietro

1999-01-01

282

Determinantes del precio de la vivienda en Santiago: Una estimación hedónica  

Microsoft Academic Search

Siguiendo la tradición de una extensa literatura de la economía urbana, desarrollada a partir de la base teórica propuesta por Rosen (1974), aquí se utiliza un modelo de precios hedónicos para analizar la determinación del precio de la vivienda (casas) en el mercado de Santiago. La estimación empírica del modelo permite explicar sobre el 70 por ciento de la varianza

Eugenio Figueroa; George Lever

283

Caracterización del mercado de energía elétrica para usuarios no regulados en Colombia  

Microsoft Academic Search

En este artículo se presenta un análisis sobre las características del mercado de energía para usuarios no regulados en Colombia, el cual puede ser considerado como un sub-mercado dentro del mercado global de energía eléctrica en Colombia. En este análisis se incluye un indicador de concentración de mercado (Herfindahl-Hirschman), así como los porcentajes de participación en cubrimiento de demanda y

Ana Cecilia Escudero; Sergio Botero Botero

2006-01-01

284

Boletín No 11: Caracterización del Trabajo Independiente y su Afiliación a la Seguridad Social en Colombia  

Microsoft Academic Search

El tema central del presente Boletín es aparentemente un tema de coyuntura. En efecto, la afiliación del trabajador independiente al sistema de seguridad social integral está generando arduos debates, económicos y jurídicos, desde la implementación de la Planilla Integrada de Liquidación de Aportes –PILA- a mediados de este año. Sin embargo, el trabajo independiente en relación a la seguridad social

Stefano Farne; Jesus Perdomo; Carlos Andrés Vergara

2008-01-01

285

Eleven new cases of del(9p) and features from 80 cases  

Microsoft Academic Search

We report 11 cases of del(9p) and review 69 previously published ones. Of the 80 cases, 39 have a del(9p) as the sole anomaly. The symptoms are typical and diagnosis should be suspected at birth. The sex ratio does not appear to be unbalanced. A cardiac murmur is often present but surgery is rarely necessary. Mean IQ is 48. The

J L Huret; C Leonard; B Forestier; M O Rethoré; J Lejeune

1988-01-01

286

ERUPCIÓN DEL VOLCÁN HUDSON Y CRISIS GANADERA EN LA MESETA CENTRAL SANTACRUCEÑA, PATAGONIA ARGENTINA  

Microsoft Academic Search

El sector ovino-extensivo de la Meseta Central Santacruceña, extensa región ecológica del centro-Norte de la provincia de Santa Cruz (Patagonia Argentina), en las últimas décadas atraviesa una situación de crisis, evidenciada en el escaso porcentaje de parcelas que mantienen el uso del suelo tradicional. Las interpretaciones con respecto a las causas de la crisis no son muy numerosas, en la

Alberto Vazquez

2012-01-01

287

SENSIBILIDAD IN VITRO DE AISLADOS DEL HONGO PHYTOPHTHORA CAPSICI A FUNGUICID AS  

Microsoft Academic Search

RESUMEN En el cultivo de chile, la incidencia de la enfermedad marchitez del chile causada por el hongo oomyceto Phytophthora capsici Leo., constituye a nivel nacional, uno de los principales problemas que afectan la productividad del cultivo. El presente estudio tuvo como objetivo: conocer la respuesta de 14 aislados de Phytophthora capsici a diferentes fungicidas. Los fungicidas utilizados fueron azoxystrobin,

Luis Pérez-Moreno; Luisa Josefina Durán-Ortiz; Rafael Ramírez-Malagón; Jesús Ricardo Sánchez-Pale; Víctor Olalde-Portugal

288

Descubrimiento del conocimiento en base de datos utilizando herramienta de software libre, caso: DAIS  

Microsoft Academic Search

El desempeño académico es un indicador que muestra el nivel de desempeño escolar de los estudiantes, en el presente artículo se describe los resultados del proceso de descubrimiento del conocimiento en bases de datos (KDD) para identificar las asignaturas que inciden en el rendimiento académico de los estudiantes de la División Académica de Informática y Sistemas de la Universidad Juárez

José Luís Gómez Ramos; Homero Alpuín Jiménez; Candelario Vicente Osorio; Mirtha Angelica; Taracena Martinez

289

Efecto de la modificación del perfil en el rendimiento de altavoces dinámicos de radiación directa  

Microsoft Academic Search

Uno de los parámetros más significativos de los altavoces es, probablemente, su rendimiento. Este puede definirse como la relación entre la potencia radiada y la potencia eléctrica consumida. Normalmente se\\u000aexpresa en % y puede ser determinado aplicado expresiones en las que figuran los valores de los componentes del circuito equivalente del altavoz. Un primer elemento necesario es la impedancia

Jesús Alba Fernández; Jaime Ramis Soriano

1970-01-01

290

El desarrollo de la creatividad a través del proceso docente como problema social  

Microsoft Academic Search

El artículo tiene como propósito reflejar aspectos sobre el desarrollo de la creatividad en estudiantes de Educación Inicial del Programa Nacional de Formación de Educadores y Educadoras (PNFE). En tal sentido el Problema científico es ¿Cómo perfeccionar los modos de actuación en los estudiantes del PNFE? El Objetivo está dirigido a la Elaboración de una metodología para favorecer el desarrollo

Magaly Sarmiento Romero

2011-01-01

291

62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION D, HIGHWAY 1. REDWOOD CLEARING ON EXISTING LINE, 1-DN-71-A #26, R.L.T. 11-1-34. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

292

El cuento del cáncer de cérvix podría tener un final feliz  

Cancer.gov

El cuento del cáncer de cérvix podría tener un final feliz Por el Instituto Nacional del Cáncer El cáncer de cérvix fue en un tiempo la causa principal de muerte por cáncer entre mujeres estadounidenses. Pero, en los últimos 50 años, el número de

293

Aspectos generales de la Red Nacional de Estudios Clínicos del NCI  

Cancer.gov

Reseña general sobre la estructura organizativa de la Red Nacional de Estudios Clínicos del NCI, así como un resumen de los cambios que se están llevando a cabo y una sinopsis de cómo estos cambios se basan en el éxito del programa de Grupos Cooperativos.

294

63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

295

Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT)  

Cancer.gov

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años y medio, no impiden el cáncer de próstata.

296

Los grupos fricativa+nasal del polaco: realización sonora y fenómenos intermedios  

Microsoft Academic Search

El presente trabajo es un estudio de la sonoridad y de los fenómenos intermedios en la realización de los grupos consonanticos fricativa + nasal del polaco. El estudio acústico se ha realizado mediante el sistema CSL, en el que se pueden observar simultáneamente el oscilograma, el espectrograma, la onda glotal y los pulsos glotales. Los resultados del análisis han puesto

Dorota Szmidt; Joan Castellví Vives

2006-01-01

297

Crueldad, simulacion, absurdo y amenaza: Barbarie del drama moderno y tradicion hermetica en los esperpentos de Ramon del Valle-Inclan  

Microsoft Academic Search

The purpose of this dissertation is to demonstrate that the esperpentos by the Spanish playwright Ramón del Valle-Inclán (1866–1936), represent a culminating moment of theatrical precepts of modern European drama, while perpetuating the ancient esoteric traditions of the Iberian Peninsula. Focusing on four plays—Los cuernos de Don Friolera (1920), Luces de Bohemia (1921), Las galas del difunto (1926) y La

Barbara Safille

2004-01-01

298

Metodologie di diagnosi e monitoraggio della malattia dell'Occhio Secco: Rapporto del Sottocomitato Metodologia Diagnostica del Workshop Internazionale dell'Occhio Secco (2007) Metodologia Diagnostica  

Microsoft Academic Search

Il ruolo del Sottocomitato Metodologia Diagno- stica del Workshop dell'Occhio Secco è stato: 1) identificare i test utilizzati per lo screening, la diagnostica e il monito- raggio dell'occhio secco, 2) stabilire i criteri per l'esecuzione dei test e 3) valutare l'utilizzo dei test per i vari impieghi clini- ci. Il Comitato ha creato un database di test utilizzati per dia-

Membri del Sottocomitato; Metodologia Diagnostica; Antony J. Bron; Anthony J. Bron; Mark B. Abelson; George Ousler; E. Pearce; Alan Tomlinson; Norihiko Yokoi; Janine A. Smith; Carolyn Begley; Barbara Caffery; Kelly Nichols; Debra Schaumberg; Oliver Schein; Margarita Calonge; Christophe Baudouin; Eiki Goto; Franz Grus; Jerry Paugh

299

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013

...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund...petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...

2013-01-29

300

Screening of antibacterial activity of Amaicha del Valle (Tucumán, Argentina) propolis.  

PubMed

Propolis is extensively used in Argentine folk medicine. Alcoholic extracts of propolis from four localities of Amaicha del Valle (El Paraiso, La Banda Este, La Banda Oeste and El Molino), Province of Tucumán and from Cerrillos, Province of Santiago del Estero, Argentina were prepared. All showed antibacterial activity against Gram positive bacteria, the propolis from La Banda Este being the most active (MIC = 7.8 microg/ml) against Streptococcus piogenes, an antibiotic resistant bacterium. Thin layer chromatographic (TLC) separation profiles of propolis from Amaicha del Valle region were similar but differ from the alcoholic extract of the propolis from Cerrillos, another phytogeographical region of Argentina (provincia chaqueña). Bioautographic assays of the TLC profiles showed that several separated compounds of the Amaicha del Valle propolis have antibacterial activity. The difference in composition between Amaicha del Valle and Cerrillos propolis coincides with a different phytogeographical formation. PMID:10624867

Nieva Moreno, M I; Isla, M I; Cudmani, N G; Vattuone, M A; Sampietro, A R

1999-12-15

301

ACTIVIDADES FORESTALES Y SU RELACIÓN CON EL SIG EN FORESTAL BOSQUES DEL PLATA S.A. FORESTRY ACTIVITIES AND THEY RELATIONSHIPS WITH THE GIS IN FORESTAL BOSQUES DEL PLATA S.A  

Microsoft Academic Search

Resumen El objetivo del presente trabajo es presentar las relaciones existentes entre algunas de las actividades forestales actualmente desarrolladas en Forestal Bosques del Plata S.A. y el sistema de información geográfica (SIG) vigente. Con el uso de nuevas tecnologías y capacitación del personal se han desarrollado proyectos de estudios de plantación establecida, instalación de parcelas permanentes, fichas de rodal y

R. Trujillo; R. Pezzutti; S. Schmidt; F. Rodríguez

302

Infraestructuras urbanas de la Segunda Revolución Tecnológica. La difusión del teléfono en las ciudades españolas, 1877-1930  

Microsoft Academic Search

El uso del teléfono es en el mundo globalizado de hoy algo tan indisolublemente ligado a nuestros hábitos cotidianos que resulta casi impensable concebir una época en que tal servicio estuviera ausente. Profundizar en el estudio del origen y desarrollo del teléfono supone, pues, enfrentarse con algunas de las claves de la civilización actual. \\u000a\\u000aLa difusión del teléfono en las

Àngel Calvo Calvo

2007-01-01

303

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect  

PubMed Central

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF.

Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stephanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noelie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander

2012-01-01

304

Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps  

NASA Astrophysics Data System (ADS)

The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the east face of Monte Rosa, for interruption of the access trail to the Rifugio Zamboni by overrid- ing and/or collapse of the lateral moraine, for impacts by ice invading various instal- lations (cable car, restaurant, ski runs, trails) near the moraine hill of Belvedere, and for sudden outbursts of pressurized subglacial water or the newly formed supraglacial lake must be envisaged.

Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

305

Evaluación y perspectivas del Código Nacional de Recursos Naturales de Colombia en sus 30 años de vigencia  

Microsoft Academic Search

Los artículos presentados estudian la eficacia, vigencia y perspectivas del Código Nacional de Recursos Naturales, decreto 2811 de 1974, teniendo de presente el avanzado estado de la ciencia en Colombia establecido por la Constitución del 91, y la Ley 99 de 1993; de esta manera los doctrinantes retoman la historia y las funciones del Código, la biodiversidad, la diversidad de

Autores varios

306

Taphonomy of guanaco bones in Tierra del Fuego  

NASA Astrophysics Data System (ADS)

Guanaco carcasses are deposited in great quantities in Cabo San Pablo, Tierra del Fuego (Argentina), as a result of winter stress. Taphonomic studies indicate that the gnawing action of foxes on guanaco ( Lama guanicoe) carcasses produces only very tenuous marks on the bones. Lack of sustained interest in the carcasses by carnivores results in slow disarticulation. The articulated and disarticulated bones are exposed to heavy trampling by guanacos, a process that produces vertical migration of small/dense bones and fracturing of the most weathered bones. An understanding of this ongoing process is important for local archaeology, since modern bones are migrating into archaeological contexts. A regional approach to taphonomy is the most appropriate instrument to solve this and other related problems.

Borrero, Luis Alberto

1990-11-01

307

Clean cities: Award winning coalition -- Paso del Norte  

SciTech Connect

Designated the 41st Clean Cities coalition in November 1995, the Paso del Norte Clean Cities Coalition (PDNCCC) is the first in the country to gain international participation. Spanning the US-Mexico border; the coalition includes stakeholders from El Paso, Texas; Ciudad Juarez, Mexico; and Las Cruces, New Mexico. PDNCCC developed a comprehensive plan to jump-start its program place, alternative fuel vehicles (AFVs) on the road, and eliminate barriers inhibiting alternative fuel market growth. PDNCC raised more than $2.3 million for alternative fuel activities and clean air initiatives in less than 26 months. In 1998, the US Department of Energy (DOE) recognized that PDNCCC accomplishment with its Rainmaker Award for leveraging the most funds from outside sources. PDNCCC is proud of its efforts to drive the alternative fuels and AFV market in the El Paso/Juarez region.

O'Connor, K.

1999-10-25

308

High precision ages from the Torres del Paine Intrusion, Chile  

NASA Astrophysics Data System (ADS)

The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic complex by the granite and we conclude that some parts of the mafic complex were emplaced before the granite. The well defined 206/238U-age for zircons and the slightly younger 40Ar/39Ar -ages for biotites of both rock suites show that emplacement and cooling of the Torres del Paine Intrusion took place in a relatively short time-frame. Halpern, 1973, Geological Society of America Bulletin, 84/7: 2407-2422. Sanchez et.al., 2006. V SSAGI, Punta del Este, April 2006.

Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.

2006-12-01

309

[Scorpions(Arachnida) from Bocas del Toro archipelago, Panamá].  

PubMed

Four species of buthid scorpions (Ananteris platnicki Lourenço, 1993; Centruroides limbatus [Pocock, 1898]; Tityus pachyurus [Pocock, 1897]; and T. ocelote Francke and Stockwell, 1987) are recorded for the first time from some islands and cays of the Bocas del Toro Archipelago, Panama. Morphological variation and ecological data are given for all the species. This is the first Panamanian record for both C. limbatus and T. ocelote. The scorpion fauna of the Bocas de Toro Archipelago is related with the recent fauna of the Atlantic continental lowland region of Costa Rica and Panama and includes Amazonian-Guyanese (genera Ananteris and Tityus) as well as Mexican-North Central American (genus Centruroides) elements. PMID:12298241

Montoya, Michel; de Armas, Luis F

2002-03-01

310

Numerical Kähler-Einstein Metric on the Third del Pezzo  

NASA Astrophysics Data System (ADS)

The third del Pezzo surface admits a unique Kähler-Einstein metric, which is not known in closed form. The manifold’s toric structure reduces the Einstein equation to a single Monge-Ampère equation in two real dimensions. We numerically solve this nonlinear PDE using three different algorithms, and describe the resulting metric. The first two algorithms involve simulation of Ricci flow, in complex and symplectic coordinates respectively. The third algorithm involves turning the PDE into an optimization problem on a certain space of metrics, which are symplectic analogues of the “algebraic” metrics used in numerical work on Calabi-Yau manifolds. Our algorithms should be applicable to general toric manifolds. Using our metric, we compute various geometric quantities of interest, including Laplacian eigenvalues and a harmonic (1,1)-form. The metric and (1,1)-form can be used to construct a Klebanov-Tseytlin-like supergravity solution.

Doran, Charles; Headrick, Matthew; Herzog, Christopher P.; Kantor, Joshua; Wiseman, Toby

2008-09-01

311

Ozone studies in the Paso del Norte region  

NASA Astrophysics Data System (ADS)

The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results obtained from this photolysis study demonstrate that the local ground level ozone formation is not only influenced by the strong solar radiation and changing aerosol makeup, but also by other heterogeneous factors and reactions. In addition, this research provided good evidence that the ground level ozone precursor regime in El Paso during the ozone episode of June 2006 was mostly VOC-limited. Much of this estimation was derived from measurements of local ambient VOC/NOx ratios. This finding shows that at least during June 2006, the non-linear surface ozone production increased during weekends compared to workdays in a habitually VOC-limited regime. The seasonal variations of columnar ozone as measured by a Multi-filter Rotating Shadowband instrument installed at the UTEP campus are analyzed for the first time for this region and results are presented. This investigation has addressed the problem of ground-level ozone formation in the Paso del Norte region. Urban ozone is a complex problem with many aspects that are not fully understood. In this investigation, a range of techniques has been used to address the study of local surface ozone episodes with the purpose of acquiring new insights and knowledge that will help understand and remediate the diverse atmospheric pollution events that affect this bi-national region recurrently. Innovative techniques were developed and used, ranging from the use of local ambient atmospheric pollution data to the utilization of complex modeling techniques to achieve the best possible computer results. Finally, the influence of ground level ozone concentrations in admissions to hospitals for this region due to respiratory diseases is analyzed. The comprehensive results obtained in this work will help to better understand ozone formation in the Paso del Norte Region for future policy regulation implementations.

Becerra-Davila, Fernando

312

Isotope hydrology of groundwaters in the Pampa del Tamarugal, Chile  

NASA Astrophysics Data System (ADS)

The water resources in northern Chile are extremely scarce and development is limited by this. This paper discusses the isotope hydrology of groundwaters in the Pampa del Tamarugal — an area of extreme aridity (rainfall < 1 mm/yr.) — whose groundwater resources are mined for the town of Iquique, as well as for industrial and agricultural purposes. The aim of the project was to obtain information on modern recharge and to delineate, if possible recharge environments. To obtain the necessary background information a precipitation survey in the high Andes, as well as spring- and surface-water studies were carried out. The results show that a well-defined meteoric water line exists where ? 2H = (7.8 ? 18O + 10.3)% , and altitude effects depend on air-mass movements and cannot be defined without a broader regional and detailed sampling programme. However, it is still possible to assign maximum altitudes of recharge to springs in the Andes and at the eastern border of the Pampa del Tamarugal. Comparison of these data with groundwater compositions show, that these groundwaters originate from infiltrating surface water rather than directly infiltrated precipitation. A dependence of individual groundwater systems on specific quebradas (river valleys) is recognized. However, low 14C activities indicate that most of the waters pumped today are fossil and at least several hundreds if not thousands of years old. Some minor subsurface recharge does occur at the foot of the Andes, especially at Pica where high-altitude waters discharge, but even there groundwater appears to be a diminishing resource.

Fritz, P.; Suzuki, O.; Silva, C.; Salati, E.

1981-09-01

313

Higher plants as bioindicators of sulphur dioxide emissions in urban environments.  

PubMed

The evaluation of certain vascular plants that grow in the city of Madrid as biomonitors of SO(2) air pollution in urban environments has been carried out. Total concentration of sulphur in leaves of the chosen higher plants as well as other parameters in close relation to this contaminant (visible injury symptoms, chlorophyll a- and b-content and peroxidase activity) have been determined in order to study the spatial distribution and temporal changes in SO(2) deposition. Results obtained show that coniferous species such as Pinus pinea, were more sensitive to SO(2) atmospheric concentration than leafy species as Quercux ilex subspecies ballota and, in the same way, bush species, such as Pyracantha coccinea and Nerium oleander, were more sensitive than wooded species, such as Cedrus deodara and Pinus pinea, respectively. There is a higher accumulation of sulphur in vegetable species located near highways and dense traffic incidence roads and near areas with high density of population. The minimum values for accumulation of SO(2) were registered in winter and spring seasons (from January to April) due to the vegetative stop; while maximum values are obtained during the summer season (from June to September), due to the stoma opening. The highest increments in sulphur concentration, calculated as the difference between two consecutive months, are obtained in May and June for all considered species except for Cedrus deodara and Pyracantha coccinea, both species have few seasonal changes during the whole year. Some species are more sensitive to natural washing than others, showing a decrease in sulphur concentration after rainfall periods. PMID:16311823

Hijano, Concepción Fidalgo; Domínguez, Maria Dolores Petit; Gimínez, Rosario García; Sínchez, Pilar Hungría; García, Inís Sancho

2005-12-01

314

Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan.  

PubMed

Two main research questions are framing this investigation: (1) the main taxa of the medicinal importance value altered the Showbak forest stand and species composition? (2) The most safe species and what are the toxic ones (unsafe). These two research questions are the vital ones to draw a clear image about the wild medicinal plants of this investigated area of Showbak region in Jordan. 79 wild medicinal plant species were investigated in this study which are used in traditional medication for the treatment of various diseases. Most of the locals interviewed dealt with well-known safe medicinal plants such as Aaronsohnia factorovskyi Warb. et Eig., Achillea santolina L., Adiantum capillus-veneris L., Artemisia herba-alba L., Ceratonia siliqua L., Clematis recta L., Herniaria hirsuta L., Malva neglecta Wallr., Rosmarinus officinalis L., Ruta chalepensis L., Salvia triloba L., Sarcopoterium spinosa (L.) Spach., Thymbra capitata (L.) Hof, and Urginea maritima Barker. Many of the wild medicinal plants investigated were toxic and needed to be practiced by practitioners and herbalists rather than the local healers. These plants include Calotropis procera Willd R.Br., Citrullus colocynthis (L.) Sch., Datura stramonium L., Digitalis purpurea L., Ecballium elaterium (L.) A.Rich., Euphorbia helioscopia L., Euphorbia tinctoria Boiss., Glaucium corniculatum (L.) Curt., Hyoscyamus aureus L., Mandragora officinarum L., Nerium oleander L., Ricinus communis L., Solanum nigrum L., Withania somnifera (L.) Dunel. The conservation of medicinal plants and natural resources is becoming increasingly important, so this research is trying to collect information from local population concerning the use of medicinal plants in Showbak; identify the most important specie; determine the relative importance value of the species and calculate the informant consensus factor (ICF) for the medicinal plants. Obtaining results is relied on the interviewee's personal information and the medicinal use of specific plants. PMID:19429338

Al-Qura'n, S

2009-05-01

315

Application of optical spectroscopic techniques for disease diagnosis  

NASA Astrophysics Data System (ADS)

Optical spectroscopy, a truly non-invasive tool for remote diagnostics, is capable of providing valuable information on the structure and function of molecules. However, most spectroscopic techniques suffer from drawbacks, which limit their application. As a part of my dissertation work, I have developed theoretical and experimental methods to address the above mentioned issues. I have successfully applied these methods for monitoring the physical, chemical and biochemical parameters of biomolecules involved in some specific life threatening diseases like lead poisoning and age-related macular degeneration (AMD). I presented optical studies of melanosomes, which are one of the vital organelles in the human eye, also known to be responsible for a disease called age-related macular degeneration (AMD), a condition of advanced degeneration which causes progressive blindness. I used Raman spectroscopy, to first chemically identify the composition of melanosome, and then monitor the changes in its functional and chemical behavior due to long term exposure to visible light. The above study, apart from explaining the role of melanosomes in AMD, also sets the threshold power for lasers used in surgeries and other clinical applications. In the second part of my dissertation, a battery of spectroscopic techniques was successfully applied to explore the different binding sites of lead ions with the most abundant carrier protein molecule in our circulatory system, human serum albumin. I applied optical spectroscopic tools for ultrasensitive detection of heavy metal ions in solution which can also be used for lead detection at a very early stage of lead poisoning. Apart from this, I used Raman microspectroscopy to study the chemical alteration occurring inside a prostate cancer cell as a result of a treatment with a low concentrated aqueous extract of a prospective drug, Nerium Oleander. The experimental methods used in this study has tremendous potential for clinical application and will gain widespread acceptance within next few years from bench to bedside as an inexpensive and non-invasive tool compared to the other technologies.

Saha, Anushree

316

Mistletoes and mutant albino shoots on woody plants as mineral nutrient traps  

PubMed Central

Background and Aims Potassium, sulphur and zinc contents of mistletoe leaves are generally higher than in their hosts. This is attributed to the fact that chemical elements which are cycled between xylem and phloem in the process of phloem loading of sugars are trapped in the mistletoe, because these parasites do not feed their hosts. Here it is hypothesized that mutant albino shoots on otherwise green plants should behave similarly, because they lack photosynthesis and thus cannot recycle elements involved in sugar loading. Methods The mineral nutrition of the mistletoe Scurrula elata was compared with that of albino shoots on Citrus sinensis and Nerium oleander. The potential for selective nutrient uptake by the mistletoe was studied by comparing element contents of host leaves on infected and uninfected branches and by manipulation of the haustorium–shoot ratio in mistletoes. Phloem anatomy of albino leaves was compared with that of green leaves. Key Results Both mistletoes and albino leaves had higher contents of potassium, sulphur and zinc than hosts or green leaves, respectively. Hypothetical discrimination of nutrient elements during the uptake by the haustorium is not supported by our data. Anatomical studies of albino leaves showed characteristics of release phloem. Conclusions Both albino shoots and mistletoes are traps for elements normally recycled between xylem and phloem, because retranslocation of phloem mobile elements into the mother plant or the host is low or absent. It can be assumed that the lack of photosynthetic activity in albino shoots and thus of sugars needed in phloem loading is responsible for the accumulation of elements. The absence of phloem loading is reflected in phloem anatomy of these abnormal shoots. In mistletoes the evolution of a parasitic lifestyle has obviously eliminated substantial feeding of the host with photosynthates produced by the mistletoe.

Lo Gullo, M. A.; Glatzel, G.; Devkota, M.; Raimondo, F.; Trifilo, P.; Richter, H.

2012-01-01

317

El camino recorrido: el aporte del Grupo Banco Interamericano de Desarrollo (BID) a la microempresa en los últimos 30 años en El Salvador  

Microsoft Academic Search

La idea de este libro surge con motivo del décimo aniversario de la celebración del Foro Interamericano de la Microempresa, esta vez con sede en El Salvador. El objetivo del mismo es contribuir a documentar el impacto producido por iniciativas del banco durante estos treinta años de trabajo conjunto con la microempresa en El Salvador. El libro presenta un resumen

Mercedes del Carmen Góchez; Carmen Cristina Álvarez

2007-01-01

318

Modelli history-friendly dell'evoluzione delle industrie: il caso dell'industria del computer  

Microsoft Academic Search

Modelli history-friendly dell'evoluzione delle industrie: il caso dell'industria del computer (di Franco Malerba, Luigi Orsenigo) - ABSTRACT: In this paper, we review and discuss the main features of a new generation of evolutionary models: \\

Luigi Orsenigo; Franco Malerba

2001-01-01

319

Geostatistical investigations of rock masses. The Sierra del Medio Case (Argentina).  

National Technical Information Service (NTIS)

The geostatistical tehniques applied for the selection of a minimun fracturation volume in Sierra del Medio allow to quantify and qualify the variability of mechanic characteristics and density of fracture and also the level of reliability in estimations....

J. A. Matar M. A. Sarquis J. P. Girardi G. H. Tabbia

1987-01-01

320

[Progress in InDel as a new generation of genetic marker].  

PubMed

As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward. PMID:23930511

Sun, Kuan; Zhang, Su-Hua; Zhu, Ru-Xin; Zhao, Shu-Min; Li, Cheng-Tao

2013-04-01

321

The extracellular matrix protein Del1 induces apoptosis via its epidermal growth factor motif.  

PubMed

Mouse Del1 is an extracellular matrix protein mainly expressed in the developing embryo. Del1 has three EGF motifs and two discoidin domains. The second EGF motif reportedly contains an RGD sequence that binds to integrin receptors. Here, we provide evidence that Del1 protein induces cell death in vitro. Chromatin condensation and DNA laddering were observed, suggestive of apoptosis. The results of analysis using the TUNEL method and annexin V staining were also consistent with apoptosis. The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated. As little as twenty-five picomolar of recombinant E3 could induce apoptosis. PMID:20171188

Kitano, Hisataka; Kokubun, Shinichiro; Hidai, Chiaki

2010-03-19

322

EFECTO DEL GATUÑO SOBRE LA FERTILIDAD DEL SUELO Y LA BIOMASA HERBÁCEA EN PASTIZALES DEL CENTRO DE MÉXICO Effect of Catclaw Mimosa on Soil Fertility and Forage Yield in Rangelands in Central Mexico  

Microsoft Academic Search

RESUMEN El trabajo se realizó durante los años 2002 y 2003, en los estados de Aguascalientes y Jalisco, con el objetivo de evaluar el efecto del gatuño (Mimosa monancistra) en el grado de asociación de algunas variables edáficas, como pH, materia orgánica (MO), fósforo, calcio y magnesio, así como la cantidad de biomasa herbácea en tres sitios con diferente grado

Ernesto Flores; Juan Frías; Pedro Jurado; Víctor Olalde; Juan de Dios Figueroa; Arturo Valdivia; Edmundo García

323

CÁLCULO DEL VOLUMEN ESPECÍFICO DE LÍQUIDOS PUROS CON ECUACIONES DE ESTADO CÚBICAS  

Microsoft Academic Search

RESUMEN. En este trabajo se presenta una revisión de los cambios que se han producido en los últimos años en las ecuaciones de estado cúbicas de más amplia aceptación y se hace un estudio comparativo del cálculo del volumen específico de once líquidos puros por medio de cinco ecuaciones cúbicas: Van der Waals, Redlich-Kwong, Soave-Redlich-Kwong, Peng-Robinson y Valderrama-Patel- Teja .

BIBIAN HOYOS

324

Calculo del valor de la cuota lactea en las explotaciones de leche gallegas  

Microsoft Academic Search

RESUMEN: El nivel de cuota l�ctea por explotaci�n y la transferencia de cuota entre las distintas explotaciones juegan un papel principal en la reestructuraci�n del sector productor de leche en Espa�a. En este trabajo se estiman el valor de una unidad de cuota, de su valor de capitalizaci�n en el horizonte del a�o 2006 y la concreci�n de algunos determinantes

Jose Carlos De Miguel Dominguez; Tomas Perez Vidal; Xose Anton Rodriguez Gonzalez

2003-01-01

325

Avaluació de plantes protegides, amenaçades o rares al Parc Natural del Cadí-Moixeró (Pirineus orientals)  

Microsoft Academic Search

Sintetitzem els resultats obtinguts des de 1995 amb l'estudi de les plantes rares o protegides del Parc Natural del Cadí-Moixeró (Pirineus orientals, Catalunya). Es presenta una llista de flora d'interès especial d'aquest espai protegit, que actualment consta de 63 tàxons, distribuïts en 4 grups de diferent prioritat de conservació. Es donen dades sobre alguns tàxons per als quals s'han realitzat

Pere Aymerich i Boixader

2006-01-01

326

El Teatre Principal de Figueres: una història del dinou (1814-1902)  

Microsoft Academic Search

Aquest article és una aproximació a la idea, el projecte i l’execució de l’equipament\\u000apúblic més rellevant que Figueres duu del segle XIX i part del XX, juntament amb la Rambla. El significat d’aquesta construcció, excessiva per a una ciutat petita, va molt més enllà de l’edifici neoclàssic, ja que suposa una nova manera d’entendre l’urbanisme públic de la mà

Alfons Martínez i Puig

2009-01-01

327

[Molecular mechanism of RhDel phenotype in blood donation population of Chinese Harbin area].  

PubMed

This study was aimed to explore the molecular mechanism of RhDel phenotype expression in blood donors of Chinese Harbin area. Three hundred and seventy-four RhD negative donors confirmed by indirect antiglobulin test were detected by using serological and molecular methods for red blood cell RhD blood group genotyping and RH gene variant detection. And the other special samples of undetermined RhD genotype were sequenced. The results showed that 62 cases of Del type were detected in 374 negative blood donors' samples, accounting for 16.6%, among them there were 61 cases of RHD1227A, and 1 case of rare RHD Del (cde) 1 allele was found. Sequencing analysis indicated that RHD711DelC allele existed in 11 cases. In addition, the new mutant alleles were found in 3 samples. It is concluded that RHD1227A allele is generally carried allele in Del phenotype population of Chinese Harbin area and is an important genetic marker in Del phenotype individual. PMID:23257457

Li, Ji-Hong; Zhang, Chun-Yan; Sun, Jian-Hua; Liu, Jie

2012-12-01

328

Heterotic horizons, Monge-Ampère equation and del Pezzo surfaces  

NASA Astrophysics Data System (ADS)

Heterotic horizons preserving 4 supersymmetries have sections which are T 2 fibrations over 6-dimensional conformally balanced Hermitian manifolds. We give new examples of horizons with sections S 3 × S 3 × T 2 and SU(3). We then examine the heterotic horizons which are T 4 fibrations over a Kähler 4-dimensional manifold. We prove that the solutions depend on 6 functions which are determined by a non-linear differential system of 6 equations that include the Monge-Ampére equation. We show that this system has an explicit solution for the Kähler manifold S 2 × S 2. We also demonstrate that there is an associated cohomological system which has solutions on del Pezzo surfaces. We raise the question of whether for every solution of the cohomological problem there is a solution of the differential system, and so a new heterotic horizon. The horizon sections have topologies which include (( k - 1) S 2 × S 4# k( S 3 × S 3) × T 2 indicating the existence of exotic black holes. We also find an example of a horizon section which gives rise to two different near horizon geometries.

Gutowski, J.; Papadopoulos, G.

2010-10-01

329

CASP8 -652 6N Del Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Meta-Analysis  

PubMed Central

Objective Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. Methods All studies published up to October 2013 on the association between CASP8 -652 6N ins/del polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Cochrane library. The association between CASP8 -652 6N ins/del polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results Six studies with 6,325 cases and 6,842 controls were included in the meta-analysis. We observed that the CASP8 -652 6N ins/del polymorphism was significantly correlated with CRC risk when all studies were pooled into the meta-analysis (ins/del vs. ins/ins: OR?=?0.890, 95%CI 0.821–0.964, P?=?0.004; del/del + ins/del vs. ins/ins: OR?=?0.899, 95%CI 0.833–0.970, P?=?0.006). In stratified analyses by ethnicity, source of control, and quality score, significant association was observed in Asians (ins/del vs. ins/ins: OR?=?0.862, 95%CI 0.761–0.977, P?=?0.020; del/del + ins/del vs. ins/ins: OR?=?0.845, 95%CI 0.749–0.953, P?=?0.006), population-based studies (ins/del vs. ins/ins: OR?=?0.890, 95%CI 0.813–0.975, P?=?0.012; del/del + ins/del vs. ins/ins: OR?=?0.901, 95%CI 0.827–0.982, P?=?0.018), and high quality studies. However, in subgroup analysis according to cancer location, no significant association was detected. Conclusions The present meta-analysis suggests that the CASP8 is a candidate gene for CRC susceptibility. The CASP8 -652 6N ins/del polymorphism may play a protective role in CRC development especially among Asians. Further large and well-designed studies are needed to confirm this association.

Chen, Zhiping; Li, Ruolin; Wang, Jian; Deng, Yan; Li, Taijie; Qin, Xue; Li, Shan

2014-01-01

330

Resolución de problemas basada en el análisis. Hacer del análisis y del razonamiento el foco de la enseñanza de la física  

Microsoft Academic Search

Resumen. Usando los resultados provenientes de la investigación educativa en áreas tales como concepciones alternativas, diferencias entre expertos y novatos, adquisición de esquemas, sobrecarga cognitiva y análisis jerárquico, hemos desarrollado un marco para pensar sobre la organización del conocimiento y su uso para la comunicación, y sobre el razonamiento y la resolución de problemas. Basados en este marco y en

J. Leonard William; William J. Gerace; Robert J. Dufresne

2002-01-01

331

BASES PARA EL MANEJO INTEGRADO DEL RECURSO LANGOSTA (Panulirus argus) EN LA ZONA COSTERA SUR DE PINAR DEL RÍO. I. FACTORES AMBIENTALES  

Microsoft Academic Search

A study of management of costal areas in the western gulf of Batabanó, southern coast of Pinar del Río province, is presented in three parts: environmental factors, socio economical factors and integrated management. Main characteristics of natural factors are analyzed, such as river supply of water to the coast, water temperature, salinity, dissolved oxygen, turbidity, ph, nutrients and organic nitrogen

Roberto Piñeiro; Rafael Puga; Gaspar González-Sansón

332

La red exterior de Puertos del Estado: Información oceanográfica en tiempo real. Puertos del Estado deep water network: Oceanographic information in real time  

Microsoft Academic Search

SUMMARY In the last 20 years, Puertos del Estado has settled a complex marine monitoring system that allows the access to real time oceanographic and meteorological information. One of the networks in this system is the deep water network with buoys deployed at open sea. The access to this information is completely free through the web pages where users can

Marta Alfonso; José Damián López; Isabel Ruiz; Enrique Álvarez; Nuevas Tecnologías

333

ESTADO DEL ARTE DE LA IMPLEMENTACIÓN DEL MÉTODO DE CRÉDITOS ACADÉMICOS - APRENDIZAJE AUTÓNOMO EN LAS INSTITUCIONES DE EDUCACIÓN SUPERIOR EN COLOMBIA  

Microsoft Academic Search

This paper intends to assess the current situation of the application process of academic loans in higher education institutions and to visualize new decision-making scenarios to generate spaces, dynamics and methodologies needed for its appropriate implementation. The study was based on three national universities: Universidad Militar Nueva Granada in Bogotá, Corporación Universita- ria del Meta -Unimeta-, and Universidad de los

RODRIGO PALACIO GÓMEZ; CLAUDIA LILIANA; MANCERA GUZMÁN; LUIS EDGAR CRUZ; WILLIAM PARRA PIÑEROS

2006-01-01

334

Screening for F508del as a first step in the molecular diagnosis of cystic fibrosis*,**  

PubMed Central

OBJECTIVE: To determine the relevance of screening for the F508del mutation of the cystic fibrosis transmembrane conductance regulator gene as a first step in the genetic diagnosis of cystic fibrosis (CF) by associating the genotype with various clinical variables. METHODS: We evaluated 180 CF patients regarding the F508del mutation. The clinical data were obtained from the medical records of the patients and from interviews with their parents or legal guardians. RESULTS: Of the 180 patients studied, 65 (36.1%) did not carry the F508del mutation (group 0 [G0]), 67 (37.2%) were F508del heterozygous (G1), and 48 (26.7%) were F508del homozygous (G2). All three groups showed associations with the clinical variables. Homozygosis was associated with younger patients, younger age at CF diagnosis, and younger age at the first isolation of Pseudomonas aeruginosa (PA), as well as with higher prevalence of pancreatic insufficiency (PI) and non-mucoid PA (NMPA) colonization. In comparison with G1+G2 patients, G0 patients were older; first experienced clinical symptoms, digestive disease, and pulmonary disease at an older age; were older at CF diagnosis and at first PA isolation; and had a lower prevalence of PI and meconium ileus, as well as of colonization by NMPA, mucoid PA, and Burkholderia cepacia. In G1 patients, values were intermediate for age at CF diagnosis; age at first PA isolation, first pulmonary symptoms, and first clinical manifestations; MPA colonization; and OR for PI. CONCLUSIONS: The identification of F508del in 63.9% of the patients studied showed that this can be a useful tool as a first step in the genetic diagnosis of CF. The F508del genotype was associated with clinical severity of the disease, especially with the variables related to CF onset.

Marson, Fernando Augusto de Lima; Bertuzzo, Carmen Silvia; Ribeiro, Maria Angela Goncalves de Oliveira; Ribeiro, Antonio Fernando; Ribeiro, Jose Dirceu

2013-01-01

335

El comerç de pintura antiga i el col·leccionisme a Barcelona a la segona meitat del segle XIX  

Microsoft Academic Search

En aquesta presentació es fa un breu recorregut per les col·leccions pictòriques construïdes a Catalunya durant la primera meitat del segle XIX. Es citen, però, els dos precedents més destacats. El més antic és la col·lecció del músic moianès Josep Elies (1690-1779) que fou organista del convent de les Descalzas Reales de Madrid, ciutat en la qual aplegà pintura barroca

Bonaventura Bassegoda

2009-01-01

336

High-Resolution Melting Analysis as a Powerful Tool to Discriminate and Genotype Pseudomonas savastanoi Pathovars and Strains  

Microsoft Academic Search

Pseudomonas savastanoi is a serious pathogen of Olive, Oleander, Ash, and several other Oleaceae. Its epiphytic or endophytic presence in asymptomatic plants is crucial for the spread of Olive and Oleander knot disease, as already ascertained for P. savastanoi pv. savastanoi (Psv) on Olive and for pv. nerii (Psn) on Oleander, while no information is available for pv. fraxini (Psf)

Andrea Gori; Matteo Cerboneschi; Stefania Tegli

2012-01-01

337

Using Del-1 to tip the angiogenic balance in endothelial cells in modular constructs.  

PubMed

Modular tissue engineering is a method of building vascularized tissue-engineered constructs. Submillimeter-sized collagen pieces (modules) coated with a layer of endothelial cells (EC; vascular component), and with embedded functional cells, are self-assembled into a larger, three-dimensional tissue. In this study, we examined the use of developmental endothelial locus-1 (Del-1), an extracellular matrix protein with proangiogenic properties, as a means of tipping the angiogenic balance in human umbilical vein endothelial cells incorporated in modular tissue-engineered constructs. The motivation was to enhance the vascularization of these constructs upon transplantation in vivo, in this case, without the use of exogenous mesenchymal stromal cells. EC were transduced using a lentiviral construct to overexpress Del-1. The Del-1 EC formed more sprouts in a fibrin gel sprouting assay in vitro compared with eGFP (control) transduced EC, as expected. Del-1 EC had a distinct profile of gene expression (upregulation of matrix metalloproteinase-9 [MMP-9], urokinase-type plasminogen activator [uPA/PLAU], vascular endothelial growth factor [VEGF-A], and intercellular adhesion molecule-1 [ICAM-1]; downregulation of angiopoietin-2 [Ang2]), also supporting the notion of "tipping the angiogenic balance". On the other hand, contrary to our expectations, when Del-1 EC-coated modules were implanted subcutaneously in a severe combined immunodeficient/beige animal model, the proangiogenic effect of Del-1 was less remarkable. There was only a small increase in the number of blood vessels formed in Del-1 implants compared with the eGFP implants, and only few blood vessels formed at the implant site in both cases. This was presumed due to limited EC survival after transplantation. We speculate that if we could improve EC survival in our study (for example, by adding other prosurvival factors or supporting cells), we would see a greater Del-1-induced angiogenic benefit in vivo as a consequence of increased Del-1 secretion by a higher number of surviving cells. PMID:24138448

Ciucurel, Ema C; Vlahos, Alexander E; Sefton, Michael V

2014-04-01

338

Magnetic fabric of the Torres del Paine, Patagonia  

NASA Astrophysics Data System (ADS)

The Miocene bimodal Torres del Paine Intrusive Complex (TIPC) consists of the lower Paine-Mafic-Complex (PMC) and the overlaying Paine Granite. Igneous structures (layering, xenolith orientations, and major contacts) are vertical in the westernmost part of the PMC, while they are sub-horizontal in the central and eastern parts. The TPIC is very homogeneous except in the PMC where complex interactions between mafic and felsic magmas were observed. No foliation or lineations are present in the field. Based on field-observations we distinguish at least three different sheet-like units in the Paine Granite, each one several tens to hundreds of meters thick. Younger sheets generally under-plate their precursor. We measured the anisotropy of magnetic susceptibility (AMS) on 145 samples from sites distributed horizontally over the entire surface of the TPIC and along 4 vertical profiles. The high intensity of the magnetic susceptibility for most of the Paine Granite and the PMC samples is due to the presence of magnetite. The magnetic lineations show a general WNW-ESE trend, parallel to the long axis of the intrusion. Lineations in the western part are strongly west-dipping to subvertical, parallel to the magmatic layering in the PMC. This supports the interpretation of a feeder-zone in that area. The lineations are sub-horizontal in the rest of the intrusion. Only minor variations in lineation orientation are observed in several hundred meter long vertical profiles in the central part of the Paine Granite. The magnetic foliations show the structural control exerted by the contact of the intrusion during its assembly: they are mostly horizontal in the central part, and are progressively steeper towards the contact. The low anisotropy is in agreement with the absence of texture observed in the field and thin sections. No sub-solidus deformation took place during the TPIC construction. The internal structures and magnetic fabrics support the interpretation of an intrusion assembled by horizontal transfer of magma in the form of sheet-like pulses stacking them vertically. Our results also show that the regional syn-magmatic deformation played no role in the emplacement of the TPIC.

Michel, J.; Baumgartner, L.; de Saint-Blanquat, M.; Putlitz, B.; Sanchez, A.; Darbellay, B.; Cavargna, M.

2007-12-01

339

The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection  

NASA Astrophysics Data System (ADS)

This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize essential chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination — the limitations of predication/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available — provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency-management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or detectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error — by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produces no victims, and therein dwells its immense tragedy.

Voight, Barry

1990-07-01

340

The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection  

NASA Astrophysics Data System (ADS)

This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize important chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination - the limitations of prediction/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available - provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or defectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error - by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produced no victims, and therein dwells its immense tragedy.

Voight, Barry

1990-12-01

341

Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins  

PubMed Central

Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts. Bypass through slippage over homonucleotide repeats by transcriptional and/or translational infidelity is known to occur sporadically. However, the overall frequency of bypass and its relation to sequence composition remain unclear. Intriguingly, the occurrence of InDels and the bypass of frame-shifts are mechanistically related - occurring through slippage over repeats by DNA or RNA polymerases, or by the ribosome, respectively. Here, we show that the frequency of frame-shifting InDels, and the frequency by which they are bypassed to give full-length, functional proteins, are indeed highly correlated. Using a laboratory genetic drift, we have exhaustively mapped all InDels that occurred within a single gene. We thus compared the naive InDel repertoire that results from DNA polymerase slippage to the frame-shifting InDels tolerated following selection to maintain protein function. We found that InDels repeatedly occurred, and were bypassed, within homonucleotide repeats of 3–8 bases. The longer the repeat, the higher was the frequency of InDels formation, and the more frequent was their bypass. Besides an expected 8A repeat, other types of repeats, including short ones, and G and C repeats, were bypassed. Although obtained in vitro, our results indicate a direct link between the genetic occurrence of InDels and their phenotypic rescue, thus suggesting a potential role for frame-shifting InDels as bridging evolutionary intermediates.

Rockah-Shmuel, Liat; Toth-Petroczy, Agnes; Sela, Asaf; Wurtzel, Omri; Sorek, Rotem; Tawfik, Dan S.

2013-01-01

342

Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins.  

PubMed

Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts. Bypass through slippage over homonucleotide repeats by transcriptional and/or translational infidelity is known to occur sporadically. However, the overall frequency of bypass and its relation to sequence composition remain unclear. Intriguingly, the occurrence of InDels and the bypass of frame-shifts are mechanistically related - occurring through slippage over repeats by DNA or RNA polymerases, or by the ribosome, respectively. Here, we show that the frequency of frame-shifting InDels, and the frequency by which they are bypassed to give full-length, functional proteins, are indeed highly correlated. Using a laboratory genetic drift, we have exhaustively mapped all InDels that occurred within a single gene. We thus compared the naive InDel repertoire that results from DNA polymerase slippage to the frame-shifting InDels tolerated following selection to maintain protein function. We found that InDels repeatedly occurred, and were bypassed, within homonucleotide repeats of 3-8 bases. The longer the repeat, the higher was the frequency of InDels formation, and the more frequent was their bypass. Besides an expected 8A repeat, other types of repeats, including short ones, and G and C repeats, were bypassed. Although obtained in vitro, our results indicate a direct link between the genetic occurrence of InDels and their phenotypic rescue, thus suggesting a potential role for frame-shifting InDels as bridging evolutionary intermediates. PMID:24204297

Rockah-Shmuel, Liat; Tóth-Petróczy, Ágnes; Sela, Asaf; Wurtzel, Omri; Sorek, Rotem; Tawfik, Dan S

2013-10-01

343

Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta  

NASA Astrophysics Data System (ADS)

Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

Cirigliano, D.; Vial, J.-C.; Rovira, M.

344

CASE REPORT: Phenotypic presentation of the Ser63Del MPZ mutation  

PubMed Central

Mutations in MPZ cause CMT1B, the second most frequent cause of CMT1. Elegant studies with Ser63del mice suggest that Ser63del MPZ is retained in the ER where it activates the unfolded protein response (UPR) that contributes to the neuropathy. Clinical information about patients with this mutation is limited. We present clinical and electrophysiological data on a large multigenerational family with CMT1B caused by Ser63del MPZ. The patients have a classical CMT1 phenotype that is much less severe than that of patients with Arg98Cys MPZ that also activates the UPR. These results suggest that clinical presentation along cannot predict which MPZ mutations will be retained in the ER and activate the UPR.

Miller, Lindsey J.; Patzko, Agnes; Lewis, Richard A.; Shy, Michael E.

2013-01-01

345

Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)  

USGS Publications Warehouse

A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio, O.

1998-01-01

346

EVALUACIÓN DEL CRECIMIENTO Y PRODUCCIÓN DE Pleurotus ostreatus SOBRE DIFERENTES RESIDUOS AGROINDUSTRIALES DEL DEPARTAMENTO DE CUNDINAMARCA EVALUATION OF GROWTH AND PRODUCTION OF Pleurotus ostreatus ON DIFFERENT AGROINDUSTRIALS WASTES OF CUNDINAMARCA  

Microsoft Academic Search

Resumen Se llevó a cabo la evaluación del cultivo de Pleurotus ostreatus, para determinar el residuo sobre el cual este hongo genera mejor crecimiento y producción. Los sustratos evaluados fueron residuos agroindustriales del departamento de Cundinamarca (capacho de uchuva, cáscara de arveja y tusa de maíz); teniendo como sustrato control el aserrín de roble. Las mezclas a evaluar fueron empacadas

Claudia López-Rodríguez; Ricardo Hernández-Corredor; Christian Suárez-Franco; Marta Borrero; Facultad de Ciencias

2008-01-01

347

Origin and distribution of the BRCA2-8765delAG mutation in breast cancer  

PubMed Central

Background The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families. We evaluated both the prevalence of the BRCA2-8765delAG variant in Sardinia and the putative existence of a common ancestral origin through a haplotype analysis of breast cancer family members carrying such a mutation. Methods Eight polymorphic microsatellite markers (D13S1250, centromeric, to D13S267, telomeric) spanning the BRCA2 gene locus were used for the haplotype analysis. Screening for the 8765delAG mutation was performed by PCR-based amplification of BRCA2-exon 20, followed by automated sequencing. Results Among families with high recurrence of breast cancer (? 3 cases in first-degree relatives), those from North Sardinia shared the same haplotype whereas the families from French Canadian and Jewish-Yemenite populations presented distinct genetic assets at the BRCA2 locus. Screening for the BRCA2-8765delAG variant among unselected and consecutively-collected breast cancer patients originating from the entire Sardinia revealed that such a mutation is present in the northern part of the island only [9/648 (1.4%) among cases from North Sardinia versus 0/493 among cases from South Sardinia]. Conclusion The BRCA2-8765delAG has an independent origin in geographically and ethnically distinct populations, acting as a founder mutation in North but not in South Sardinia. Since BRCA2-8765delAG occurs within a triplet repeat sequence of AGAGAG, our study further confirmed the existence of a mutational hot-spot at this genomic position (additional genetic factors within each single population might be involved in generating such a mutation).

Palomba, Grazia; Cossu, Antonio; Friedman, Eitan; Budroni, Mario; Farris, Antonio; Contu, Antonio; Pisano, Marina; Baldinu, Paola; Sini, Maria C; Tanda, Francesco; Palmieri, Giuseppe

2007-01-01

348

[Il ruolo del cervelletto nella depressione unipolare e bipolare: una rassegna delle principali evidenze neurobiologiche].  

PubMed

riassunto. Evidenze derivanti da numerosi studi condotti sia su pazienti affetti da patologie cerebellari sia su soggetti sani suggeriscono che il cervelletto eserciti, oltre a un ruolo ormai ben definito nel controllo e nella regolazione delle funzioni motorie, una significativa attività di modulatore del tono dell'umore, del comportamento e delle funzioni cognitive. In questo lavoro di revisione abbiamo passato in rassegna tutti quegli studi di neuroimaging volti a indagare la presenza di alterazioni cerebellari sia morfologiche sia funzionali in pazienti affetti da disturbo bipolare (DB) e disturbo depressivo maggiore (DDM), ipotizzando l'esistenza di un meccanismo fisiopatologico alla base di questi disturbi, che coinvolga, almeno in parte, il cervelletto. Allo stesso scopo, sono stati esaminati anche quegli studi post mortem che indagavano la presenza di alterazioni cellulari e molecolari a partire da campioni di tessuto cerebellare, per esempio alterazioni delle proteine mitocondriali, della tirosin-chinasi B e del brain-derived neurotrophic factor (BDNF), del fattore di trascrizione SP4, della proteina fibrillare acida della glia (GFAP). In totale sono stati esaminati 28 studi, 12 inerenti le alterazioni morfologiche e funzionali del cervelletto nel DB, 13 inerenti le alterazioni morfologiche e funzionali del cervelletto nel DDM e 4 inerenti le alterazioni cerebellari post mortem in entrambi i disturbi. Dal nostro lavoro di revisione, in linea con quanto presente nella letteratura internazionale, emerge l'interessante ipotesi che il cervelletto funzioni come un "pacemaker emotivo" e che quindi una sua lesione potrebbe tradursi nell'incapacità dell'individuo di rimanere in equilibrio sulla sottile linea dell'eutimia, giustificando in questo modo la comparsa di profonde oscillazioni emotive sia sul versante depressivo sia su quello maniacale. PMID:25000888

Minichino, Amedeo; Bersani, Francesco Saverio; Trabucchi, Guido; Albano, Gabriella; Primavera, Martina; Delle Chiaie, Roberto; Biondi, Massimo

2014-01-01

349

Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations  

PubMed Central

The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ?2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5?MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ?5?MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750–1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ?650 years ago, and into the Iraqi–Jewish community ?450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews.

Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan

2013-01-01

350

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity.  

PubMed

Balanites aegyptiaca Del. (Zygophyllaceae), known as 'desert date,' is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

Chothani, Daya L; Vaghasiya, H U

2011-01-01

351

Parental origin of de novo chromosome 9 deletions in del(9p) syndrome  

SciTech Connect

Parental origin of de novo deletions in the short arm of chromosome 9 in patients with a clinical diagnosis of del(9p) syndrome was assessed in 13 patients using polymerase chain reaction (PCR) analysis of highly polymorphic dinucleotide repeat microsatellite markers located in the putative deleted region. The deletion was found to be of paternal origin in 9 cases and of maternal origin in the remaining 4 cases, suggesting that the molecular event resulting in the deletion occurs in both male and female gametogenesis and that genomic imprinting does not appear to play a role in the pathogenesis of del(9p) syndrome. 22 refs., 1 fig.

Micale, M.A.; Haren, J.M.; Conroy, J.M. [Case Western University School of Medicine, Clevelend, OH (United States)

1995-05-22

352

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity  

PubMed Central

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

Chothani, Daya L.; Vaghasiya, H. U.

2011-01-01

353

Energy and Momentum in Spacetime Homogeneous G$\\\\ddot{o}$del-type Metrics  

Microsoft Academic Search

Using Einstein and Papapetrou energy-momentum complexes, we explicitly\\u000acalculate the energy and momentum distribution associated with spacetime\\u000ahomogeneous G$\\\\ddot{o}$del-type metrics. We obtain that the two definitions of\\u000aenergy-momentum complexes do not provide the same result for these type of\\u000ametrics. However, it is shown that the results obtained are reduced to the\\u000aenergy-momentum densities of G$\\\\ddot{o}$del metric already available in

M. Sharif

2003-01-01

354

Taphonomic alterations in upper Viséan dissepimented rugose corals from the Sierra del Castillo unit (Carboniferous, Córdoba, Spain)  

Microsoft Academic Search

Dissepimented rugose corals are common in the Sierra del Castillo Unit (upper Viséan from SW Spain). A complete taphonomic study has been made of the corals from three localities, each representing different environmental conditions: Antolín rocks are interpreted as mid-ramp and contains mainly reworked corals from reefs, Sierra del Castillo rocks are regarded as originating on a shallow-water platform, and

Sergio Rodríguez

2004-01-01

355

Una nota sobre la sostenibilidad fiscal y el nexo entre los ingresos y gastos del Gobierno Colombiano  

Microsoft Academic Search

En este trabajo se analiza empíricamente la sostenibilidad fiscal en Colombia a través de las técnicas de cointegración. En particular, usando los ingresos tributarios y los gastos primarios del gobierno nacional central para el período 1990Q1 a 2008Q4 (datos reales y ajustados por el ciclo económico), en el documento se examina si las cuentas fiscales del gobierno han sido sostenibles

Ignacio Lozano; Enrique Cabrera

2009-01-01

356

Acuerdos entre el gobierno central y los departamentos: una propuesta para aumentar la eficiencia del gasto público  

Microsoft Academic Search

El objetivo de este trabajo es proponer un instrumento para el seguimiento de la eficiencia del gasto público. El instrumento muestra que el gobierno central se puede apoyar en las administraciones departamentales con el fin de medir los productos del gasto. La idea central de la propuesta es que los objetivos de productividad acordados entre el nivel nacional y el

Isaac de León-Beltrán; Diego Jaramillo

2006-01-01

357

Estudio Multicentrico de Prevalencia del Trastorno por Déficit de Atención e Hiperactividad en la República Argentina1  

Microsoft Academic Search

El presente es el primer estudio de prevalencia del Trastorno por Déficit de Atención realizado en la República Argentina. Se utilizó una muestra de inicial de 898 niños de 6 a 9 años correspondientes a los tres primeros años de escuelas primarias del Gran Buenos Aires que tras ser depurada quedó conformada por 801 niños de ambos sexos. Metodología: Para

Ruben O. Scandar

358

MORFOLOGIA DE LOS GRANOS DE POLEN DE LAS FAMILIAS ACANTHACEAE, VITACEAE Y VIOLACEAE DEL VALLE DE MEXICO  

Microsoft Academic Search

2 RESUMEN Se estudia e ilustra la morfología del polen de las familias Acanthaceae, Vitaceae y Violaceae pertenecientes a la flora del Valle de México; la primera está representada por: Acanthus mollis L., Anisacanthus quadrifidus (Vahl) Standley, Dicliptera peduncularis Nees, Dyschoriste decumbens (Gray) O. Ktze., D. microphylla (Cav.) O. Ktze., Justicia furcata Jacq., Pseuderanthemum praecox (Benth.) Leonard, Ruellia bourgaei Hemsl.,

RODOLFO PALACIOS-CHAVEZ; DAVID LEONOR QUIROZ-GARCIA

359

DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT  

EPA Science Inventory

EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

360

Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.  

PubMed

Most cases of cystic fibrosis (CF) are attributable to the F508del allele of CFTR, which causes the protein to be retained in the endoplasmic reticulum (ER) and subsequently degraded. One strategy for CF therapy is to identify corrector compounds that help traffic F508del-CFTR to the cell surface. Pharmacological chaperones, or correctors that bind specifically to F508del-CFTR and restore function, would be the most promising drug development candidates, but few pharmacological chaperones exist for F508del-CFTR. Using differential scanning fluorimetry (DSF), we have surveyed corrector compounds and identified one, RDR1, which binds directly to the first nucleotide binding domain (NBD1) of F508del-CFTR. We show that RDR1 treatment partially rescues F508del-CFTR function in both cells and in an F508del-CF mouse model. Thus, RDR1 is a pharmacological chaperone of F508del-CFTR and represents a novel scaffold for drug development. PMID:21338920

Sampson, Heidi M; Robert, Renaud; Liao, Jie; Matthes, Elizabeth; Carlile, Graeme W; Hanrahan, John W; Thomas, David Y

2011-02-25

361

El espejismo del desarrollo y la globalización económica en los países de América Latina. (Axe II, Symposium 8)  

Microsoft Academic Search

El presente trabajo tiene el objetivo de reflexionar sobre el discurso del concepto de “globalización económica” que conlleva la ilusión de ofrecer un “desarrollo económico” que no es equivalente a lo que denominamos “desarrollo total” de una sociedad, ya que éste se refiere sólo a una dimensión parcial del proceso: la estrictamente económica. El cuestionamiento que nos hacemos es ¿Por

Marco Antonio Merchand

2010-01-01

362

SISTEMA DE INDICADORES PARA LA EVALUACIÓN DE LA APLICACIÓN DEL SISTEMA DE GESTIÓN AMBIENTAL EN EMPRESAS CONSTRUCTORAS  

Microsoft Academic Search

Se tuvo como objetivo la propuesta de un sistema de indicadores para la evaluación de la aplicación del Sistema de Gestión Ambiental en empresas constructoras y la elaboración de un software para el procesamiento de los mismos, que contribuya a elevar la eficacia de la evaluación del desempeño ambiental y los resultados de las organizaciones de este tipo. Este sistema

Ninfa del Carmen Moncada Serrano

2012-01-01

363

Evaluación del ciclo de vida aplicada en agrocadenas productivas: un instrumento de gestión ambiental para el diseño de políticas  

Microsoft Academic Search

La Evaluación del Ciclo de Vida del Producto (ECV) ha sido sugerida como un instrumento adecuado para ampliar el análisis y formulación de estrategias y políticas al utilizar el enfoque de Cadenas Globales de Mercancías. En este artículo se analizan los alcances de la aplicación de la ECV en diferentes sistemas de gestión ambiental lo cual permite establecer las áreas

Rafael Díaz Porras; Marjorie Hartley Ballestero

2006-01-01

364

Gestión para el desarrollo local sostenible en Granjas Agroindustriales y Empresas Azucareras del MINAZ de la provincia de Cienfuegos  

Microsoft Academic Search

La investigación se realizó en las entidades del MINAZ, teniendo como título: “Gestión para el desarrollo local sostenible en Granjas Agroindustriales y Empresas Azucareras del MINAZ en la provincia de Cienfuegos”. Tiene como objetivo general proponer un sistema de gestión ambiental integral que permita valorar e implantar las políticas de desarrollo local sostenible de las granjas agroindustriales y empresas azucareras

Eduardo Julio López Bastida; Mileisy Balbis Morejón

2008-01-01

365

Carta abierta a las organizaciones y personas que trabajan en el área del cáncer acerca de los estudios clínicos en la comunidad  

Cancer.gov

El doctor Varmus reafirma el compromiso del NCI con los pacientes que participan en estudios clínicos en la comunidad y explica en qué consiste la transición al nuevo Programa de Investigación Oncológica Comunitaria del NCI (NCORP).

366

["Legal highs": paradisi sicuri e legali? Uno studio sulla diffusione, conoscenza e consapevolezza del rischio delle nuove droghe psicoattive tra gli studenti del Regno Unito].  

PubMed

RIASSUNTO. Introduzione. La recente comparsa delle nuove sostanze ricreazionali, combinata alla possibilità offerta da Internet di diffondere le informazioni velocemente, ha sollevato numerose nuove preoccupazioni nel campo legislativo, nel campo della ricerca sulle nuove sostanze e per quanto riguarda la salute pubblica. Metodi. È stato utilizzato un questionario semistrutturato pubblicizzato sul sito di Study Room da novembre a dicembre 2010 per esplorare la consapevolezza, l'uso e la percezione di rischio delle "legal highs" tra la popolazione studentesca nel Regno Unito. Risultati. Un terzo (31,40%) dei 446 partecipanti ha riferito l'uso di queste sostanze. Gli intervistati hanno riferito soprattutto l'uso di: mefedrone (41,4%), Salvia divinorum (20%), "spice drugs" (10,7%), metilone (1,4%), nafirone (NRG) (2,1%) e benzilpiperazina (BZP) (2,1%), mentre il 15,7% non sapeva che tipo di composto avesse assunto. La maggioranza (78,9%) considerava queste sostanze "legali", mentre il 74,2% non le considerava più sicure di composti illegali. Metà del campione (50,8%) era consapevole della presenza di componenti illegali nei prodotti consumati. Conclusioni. Lo studio contribuisce al tentativo di stimare l'uso e la consapevolezza del rischio in merito alle nuove sostanze psicoattive tra gli studenti del Regno Unito. Si ritengono necessari ulteriori studi, soprattutto in termini di personalità e stili di vita, al fine di inquadrare meglio queste nuove forme di abuso, anche in setting non propriamente ricreazionali. PMID:24770577

Corazza, Ornella; Simonato, Pierluigi; Corkery, John; Trincas, Giuseppina; Schifano, Fabrizio

2014-01-01

367

El trabajo político e ideológico en la universidad cubana de hoy. El socialismo en las nuevas condiciones del siglo XXI: una opción viable  

Microsoft Academic Search

Un objetivo de primer orden en todos los años de Revolución ha sido lograr en los graduados universitarios la formación integral de un profesional revolucionario. Los cambios operados en la situación internacional después del derrumbe del campo socialista y la desaparición de la URSS así como el incremento de la agresividad económica e ideológica del gobierno de Estados Unidos y

Anay Pulgarón Ramos

2011-01-01

368

Valoración de impactos socio- ambientales del arbolado urbano: una aplicación a la ciudad de Santiago, Chile  

Microsoft Academic Search

Santiago de Chile es tercero en la lista de ciudades más contaminadas de Latinoamérica, después de Ciudad de México y Sao Paulo, por lo cual la valoración ambiental y social del arbolado urbano en este contexto es de vital importancia. Los proyectos de arbolado urbano ya sea en calles, plazas, parques u otras áreas verdes tienen como propósito, por una

Carmen L. De la Maz; Claudia L. Cerd

2009-01-01

369

Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

Microsoft Academic Search

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites.

G. B. Wiersma; A. Kohler; C. Boelcke; G. Baker; M. Harmon; C. Weber; J. Gonzales

1985-01-01

370

Efectos heterogéneos del trabajo infantil en la adquisición de habilidades cognitivas  

Microsoft Academic Search

El estudio se ocupa de los efectos heterogéneos del trabajo en la formación de capital humano a través de una definición amplia de trabajo que incluye toda actividad asociada a responsabilidades no escolares. Dada la variedad de responsabilidades asumidas por niños y adolescentes peruanos, se toma en cuenta dos criterios para clasificar los diferentes tipos de trabajo: el tipo de

Carmen Ponce

2012-01-01

371

Las políticas públicas de fomento del reciclaje: La regeneración de aceites usados  

Microsoft Academic Search

Los aceites usados son un residuo peligroso del que pueden derivarse graves daños medioambientales si su gestión es inadecuada; al mismo tiempo, tienen un indudable valor económico, ya que conservan gran parte de los hidrocarburos que los lubricantes contenían originalmente. La gestión de los aceites usados ofrece distintas alternativas, dirigidas principalmente al reciclaje, siendo de destacar la combustión y la

Asunción Arner Güerre; Ramón Barberán Ortí; Jesús Mur Lacambra

2003-01-01

372

A tectonically controlled basin-fill within the Valle del Cauca, West-Central Colombia  

SciTech Connect

Tertiary strata of the Valle del Cauca reflect a forearc/foreland basin tectonic history spanning a period from pre-uplift of the Cordillera Central to initiation of uplift of the Cordillera Occidental. Stratigraphy of the Valle del Cauca begins with Jurassic-Cretaceous rocks of exotic and/or volcanic provenance and of oceanic origin. Unconformably overlying these are Eocene to Oligocene basal quartz-rich sandstones, shallow marine algal limestones, and fine-grained fluvial/deltaic mudstones and sandstones with coalbeds. These Eocene to Oligocene deposits represent a period of low tectonic activity. During late Oligocene to early Miocene, increased tectonic activity produced conglomeratic sediments which were transported from east to west, apparently derived from uplift of the Cordillera Central, and deposited within a fluvial to deltaic setting. East-west shortening of the Valle del Cauca basin folded the Eocene to early Miocene units, and additional uplift of the Cordillera Central during the later Miocene resulted in syn-tectonic deposition of alluvial fans. After additional fold and thrust deformation of the total Eocene-Miocene basin-fill, tectonic activity abated and Pliocene-Quaternary alluvial and lacustrine strata were deposited. Within the framework of this depositional and tectonic history of the Valle del Cauca, hydrocarbon exploration strategies can be formulated and evaluated.

Rine, J.M.; Keith, J.F. Jr.; Alfonso, C.A.; Ballesteros, I.; Laverde, F.; Sacks, P.E.; Secor, D.T. Jr. (Univ. of South Carolina, Columbia (United States)); Perez, V.E.; Bernal, I.; Cordoba, F.; Numpaque, L.E. (Ecopetrol, Bogota (Colombia))

1993-02-01

373

Integrated Global Background Monitoring Network. Preliminary Results from Torres Del Paine and Olympic National Parks.  

National Technical Information Service (NTIS)

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrate...

G. B. Wiersma A. Kohler C. Boelcke G. Baker M. Harmon

1985-01-01

374

Acantholachesilla gen. n. (Psocodea:'Psocoptera': Lachesillidae: Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.  

PubMed

Acantholachesilla saltoensis gen. et sp. n. is described from Valle del Cauca, Colombia, in the Lachesillidae, tribe Graphocaeciliini (Eolachesillinae). The genus is related to Dagualachesilla and Dagualachesilloides that occur in the same area, differing from them in the male clunial projection, phallosome, and female subgenital plate and gonapophyses. PMID:24989767

Aldrete, Alfonso N García; Manchola, Oscar Fernando Saenz; Obando, Ranulfo González

2014-01-01

375

¿Competencia o colusión en el mercado de gasolina? Una aproximación a través del parámetro de conducta  

Microsoft Academic Search

Este trabajo analiza la competencia en el mercado minorista de gasolinas. Para ello nos centramos en el mercado de las Islas Canarias porque ofrece dos ventajas inéditas respecto de otros mercados: la facilidad en la definición del mercado relevante (insular) y la existencia de mercados en monopolio y en oligopolio simultáneamente. Este último hecho permite estimar un modelo de variaciones

Jordi Perdiguero; Juan Luis Jiménez

2009-01-01

376

La culpa es del Yankee: Correlaciones e ineficiencias en el mercado de dinero  

Microsoft Academic Search

Los cambios en las tasas de interés de los bonos globales colombianos -mecanismo de transmisión de las presiones de los mercados internacionales sobre el mercado localson los principales causantes de las fluctuaciones en el mercado de dinero doméstico. Este fenómeno parece haberse acentuado incluso después de que los problemas del mercado de TES de fin de 2002 indujeron la conformación

Santiago Gutiérrez V; Michel Formisano P

2003-01-01

377

Historia de la investigación marina de la Isla del Coco Costa Rica  

Microsoft Academic Search

Abstract: History of marine research at Cocos Island, Costa Rica. The marine organisms and environments ofIsla del Coco (Cocos Island), Pacific Costa Rica, were described by explorers in the late 17, century, during the Albatross Expeditions. The first expedition by Costa Rican scientists was in 1898. Between the 1920’s and 1940’s, many expeditions visited the island and many papers were

Jorge Cortés

378

La reordenación y reducción del tiempo de trabajo en la Unión Europea  

Microsoft Academic Search

Si hasta la primera mitad de la década de los 80, eran las reivindicaciones sindicales en materia de reducción del tiempo de trabajo las que propiciaban acuerdos de reducción de las jornadas de trabajo y legislaciones de trabajo tendentes a reducir las joranadas máximas legales e incrementar el número de días de vacaciones anuales, con la liberalización e internacionalización de

Luis A. Rasines García; Iñigo Renovales Mota

1995-01-01

379

INNOVACIÓN EN LOS GOBIERNOS SUBNACIONALES DE MÉXICO: EL CASO DEL ESTADO DE SAN LUIS POTOSÍ  

Microsoft Academic Search

En los últimos años se ha discutido el papel de los gobiernos subnacionales como entes tomadores de decisiones y generadores de política en diversos ámbitos, considerando que las prácticas novedosas y la participación de diversos actores gubernamentales y no gubernamentales son un factor detonante del desarrollo en el diseño e implementación de política pública. Estas nuevas formas —entendidas como innovación—

Mario E. Ibarra Cortés; Erika García Méndez

2010-01-01

380

Las corporaciones autonomas regionales del caribe colombiano: Un analisis de sus finanzas y gobierno corporativo  

Microsoft Academic Search

Las Corporaciones Autónomas Regionales (car) y las Corporaciones de Desarrollo Sostenible (cds) son las instituciones encargadas de la protección del medio ambiente en Colombia. Este trabajo estudia el desempeño de las corporaciones que tienen jurisdicción sobre la Costa Caribe. En particular, examina sus principales fortalezas y limitaciones administrativas, y analiza si en sus presupuestos se reproducen las desigualdades regionales que

Joaquin Viloria de la Hoz

2011-01-01

381

Innovazione, finanza e sviluppo: aspetti del dibattito teorico e dell'evidenza empirica  

Microsoft Academic Search

Innovazione, finanza e sviluppo: aspetti del dibattito teorico e dell'evidenza empirica (di Ferruccio Bresolin) - ABSTRACT: According to Schumpeter, one of the most important problems of innovation is the search for new financial resources to dedicate to research, experimentation and innovation. The aim of this article is to provide a summary on the subject of the discussion concerning the problems

Ferruccio Bresolin

2006-01-01

382

Diagnóstico y tratamiento farmacológico del trastorno por déficit de atención e hiperactividad  

Microsoft Academic Search

. Se asocia con retraso y dificultades del funcionamiento académico y social 2 , y hay evidencia creciente que indica que también se asocia con morbilidad significativa y peor funcionamiento en la edad adulta 3,4 . Además, estudios longitudinales recientes señalan que los niños con TDAH de ambos sexos y de cual- quier edad generan un gasto médico total y

César Soutullo Esperón

2003-01-01

383

A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"  

ERIC Educational Resources Information Center

In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

Manickam, Samuel

2014-01-01

384

Genetics of Suicidal Germination of Striga hermonthica (Del.) Benth by Cotton  

Microsoft Academic Search

of the crop and abandonment of otherwise productive fields (Butler, 1995). Well over a decade ago, a conserva- The germination of giant witchweed (Striga hermonthica (Del.) tive estimate of crop losses due to Striga in Africa was Benth), a noxious root parasite of many cereal crops, is stimulated by exudates from the roots of both host and non-host trap plants.

C. J. Botanga; S. O. Alabi; C. A. Echekwu; S. T. O. Lagoke

385

Las fundaciones de ciudades y el pensamiento urbanístico hispano en la era del Descubrimiento  

Microsoft Academic Search

La historia urbana referida al periodo histórico en torno a la fecha de 1492, con sus precedentes, desde la caída de Constantinopla (1452) y su evolución hasta la entronización y asentamiento de la monarquía del Emperador Carlos (~1530), es un periodo excepcional que requiere una reinterpretación a la luz de nuevos enfoques interdisciplinarios y de nuevos descubrimientos científicos. El periodo

María Isabel Navarro Segura

2007-01-01

386

REPRODUCTIVE RHYTHMICITY OF THE ATHERINID FISH, 'COLPICHTHYS REGIS', FROM ESTERO DEL SOLDADO, SONORA, MEXICO  

EPA Science Inventory

The reproductive rhythmicity of the false grunion, Colpichthys regis, was observed in the Estero del Soldado, Mexico during October 1982 through January 1983. Spawning runs occurred at approximately 2-week intervals during daytime high tides. These high tides coincided with new a...

387

Sistemi informativi geografici come estensione del Customer Relationship Management nelle imprese e nei servizi  

Microsoft Academic Search

Sistemi informativi geografici come estensione del Customer Relationship Management nelle imprese e nei servizi (di Federica Tombari) - ABSTRACT: The paper illustrates the increasing opportunities related to the adoption of Geographic Information Systems (GIS) with the potential of Customer Database (CDB) and Customer Relationship Management (CRM) in the traditional analysis for the support decision system in the business management of

Federica Tombari

2006-01-01

388

El Instituto Nacional del Cáncer lanza el sitio en la Internet  

Cancer.gov

El Instituto Nacional del Cáncer (NCI, por sus siglas en ingls) anunci hoy el lanzamiento de Cancer.gov (http://www.cancer.gov), que ha sido mejorado significativamente, es muy fcil de navegar y brinda en un solo sitio toda la informacin sobre el cáncer

389

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells.  

PubMed

Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF. PMID:23060796

Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W; Thomas, David Y

2012-01-01

390

MEDICIÓN DE HABILIDADES DIRECTIVAS EN LOS INSTITUTOS TECNOLÓGICOS DEL SURESTE DE MÉXICO. AVANCE DE INVESTIGACIÓN  

Microsoft Academic Search

Se presentan los avances de la investigacion doctoral con los resultados del estudio piloto. En la primera fase se obtuvo la opinion de un grupo de expertos de las habilidades que requieren tener los jefes de deprtamento, los subdirectores y directores para desempeñarse en su funcion. En una segunda fase se toma una muestra representativa de los directivos de los

Gloria Pérez Garmendia; Francisco Gerardo Barroso Tanoira; José Juan Escalante Fernández; Hortensia Eliseo Dantes

2008-01-01

391

Il quadro finanziario pluriennale dell'Unione e la costruzione del processo di integrazione europea  

Microsoft Academic Search

Il quadro finanziario pluriennale dell'Unione e la costruzione del processo di integrazione europea (di Silvano Presa) - ABSTRACT: This paper assesses how the eu budget is going to be shaped over the next decade in view of meeting the challenge of growth. Firstly, the paper briefly recalls the main features of the European Union’s public finances. Secondly, it highlights the

Silvano Presa

2005-01-01

392

Design, Development and Optimization of Highly Efficient Solar Cars: Gato del Sol I-IV  

Microsoft Academic Search

Engineering students at the University of Kentucky have designed and built solar powered cars for the 2008 North American Solar Challenge and the 2009 Formula Sun Grand Prix. Gato del Sol III, our most accomplished car, is powered by a solar array of 480 Silicon monocrystalline photovoltaic cells. Maximum Power Point trackers efficiently made use of these cells and tracked

Raghu Mangu; Krishna Prayaga; Bhavananda Nadimpally; Sam Nicaise

2010-01-01

393

SISTEMA REMOTO DE ADQUISICIÓN PARA EL CONTROL DEL RUIDO AMBIENTAL CON FPGA Y FPAA  

Microsoft Academic Search

RESUMEN Este artículo propone el diseño de un sistema de adquisición de datos con componentes digitales y analógicos microelectrónicos reconfigurables, como son el FPGA (Field Programmable Gate Array) y el FPAA (Field Programmable Analog Array), para monitorear y analizar la contaminación por ruido ambiental. Este prototipo obtiene los datos del ruido de una zona vial (zona centro de una ciudad)

A. Castillo Atoche; J. Vázquez Castillo; V. Sanchez Huerta; P. Del Río Dawn

394

33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2013 CFR

...REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area . That portion of the Pacific Ocean lying shoreward of the offshore breakwater and the most seaward 1,000 feet of the entrance channel between the north and...

2013-07-01

395

L'INSEDIAMENTO EBRAICO DI SAN DANIELE DEL FRIULI NEL SETTECENTO  

Microsoft Academic Search

In many ways the Jewish community of San Daniele del Friuli enjoyed a fortunate existence compared with Jews in other settlements in the region. They were protected from the patriarchs, whose jurisdiction in San Daniele continued even after the Venetian Conquest (1420), owing to the churchstate accord of 1445. The Jews took fair advantage of this situation, in fact no

Lara Pironio

1999-01-01

396

Indicadores de riesgo y de gestión del riesgo de los desastres: resultados para Nicaragua  

Microsoft Academic Search

Los desastres naturales han repercutido en las perspectivas de desarrollo de muchos de los países de América Latina y el Caribe. Nicaragua está al frente de esta infortunada realidad, estando localizada en una de las zonas del mundo más propensa a amenazas naturales. Con el fin de apoyar a Nicaragua es reducir su vulnerabilidad frente a las amenazas y las

Omar D. Cardona

2007-01-01

397

VALORACIÓN ECONÓMICA DEL MEDIO AMBIENTE: “LAS PROPUESTAS DE LA ECONOMÍA ECOLÓGICA Y LA ECONOMÍA AMBIENTAL”  

Microsoft Academic Search

La supervivencia de la especie humana es inconcebible sin aquello que aporta el medio ambiente. Pese a ello los seres humanos hemos tendido, con el paso del tiempo, a despreciar su importancia, realizando nuestras actividades sin considerar nuestro impacto sobre él. La configuración de un sistema energético basado en la mala gestión de los recursos naturales, muchas veces utilizados a

Leonardo Granato; Nahuel Oddone; Adolfo Carballo Penela

2009-01-01

398

ANALISI SPERIMENTALE DEL CONTATTO PIANO-PIANO CON INDENTATORE CILINDRICO RACCORDATO  

Microsoft Academic Search

Sommario Nel presente studio è proposta l'analisi sperimentale, mediante ultrasuoni, del contatto tra un indentatore cilindrico piano a bordi raccordati ed un piano, problema per il quale è stata recentemente proposta una soluzione analitica mai validata sperimentalmente. Per ciascun accoppiamento è stata valutata la riflessione dall'interfaccia, che è noto essere in relazione con lo stato di contatto. I risultati sperimentali

B. Leban; M. Pau; A. Baldi; F. Ginesu

399

UN HERMANO DEL PADRE ANTONIO SOLER, FAGOTISTA DE LA REAL CAPILLA MADRILEÑA  

Microsoft Academic Search

El P. Antonio Soler tuvo al menos un hermano que también era músico y compositor: Mateo Soler, que actuó como fagotista de la Real Capilla en Madrid de 1780 a 1799, año en que murió. Damos cuenta de los pormenores biográficos tanto familiares como profesionales que hemos podido averiguar sobre este músico olvidado, del que incluso se conserva una sonata

Guy Bourligueux

1985-01-01

400

An Accretion-Disc Model for the Algol-Type Eclipsing Binary System AV Del  

Microsoft Academic Search

This study inspects the light and radial-velocity curves of the eclipsing binary AV Del. In comparison with other studies already done, the study shows that the absolute elements, fundamental orbital and physical parameters of the system can be determined using the Wilson-Devinney code. Using these parameters, the configuration of the system is presented. Then, an accretion disc model for the

S. M. R. Ghoreyshi; J. Ghanbari; F. Salehi

2011-01-01

401

Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.  

ERIC Educational Resources Information Center

A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

Luckie, Jo Ann I.; Bonham, L. Adrianne

402

Nutrición deportiva en la infancia: Cumplimiento de las demandas metabólicas del crecimiento y el ejercicio  

Microsoft Academic Search

ExtractoLos objetivos fundamentales de la infancia son el crecimiento y la maduración óptimos. Estos procesos relacionados con el desarrollo exigen un balance energético y nitrogenado positivo. Aunque la actividad física regular puede intensificar el desarrollo en la infancia, un entrenamiento físico extenuante puede reducir las reservas de energía y nitrógeno del organismo que, entonces, deberán reemplazarse a través de la

C. L. Zanker

2006-01-01

403

Declaración sobre los cambios que tendrán lugar próximamente en los programas de estudios clínicos del NCI  

Cancer.gov

Los estudios clínicos son elementos fundamentales en la transformación de los descubrimientos científicos en métodos prácticos para prevenir y tratar el cáncer. En esta declaración, hacemos un resumen de los cambios que están teniendo lugar en las organizaciones que realizan estudios clínicos bajo los auspicios del NCI.

404

ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY  

EPA Science Inventory

Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

405

Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?  

PubMed Central

Background Understanding where mutant CFTR is localised in airway epithelia is essential in guiding the best therapeutic approach to correct the dysfunction of the CFTR protein. The widely held paradigm is that CF patients harbouring the commonest mutation, CFTR-delF508, trap CFTR within the endoplasmic reticulum and target it for degradation. However there are conflicting reports concerning expression and localisation of CFTR-delF508 in lung tissue. To attempt to resolve this fundamental issue we developed a novel approach to measure CFTR-delF508 in the lower airways of patients who have undergone lung transplantation for advanced CF. By sampling CF and non-CF epithelium simultaneously from the same individual, confounding factors of different airway microenvironments which may have influenced previous observations can be overcome. Methods Epithelia sampled by bronchial brushing above (CF) and below (non-CF) the bronchial anastomosis were stained for CFTR and the localisation and level of expression assessed (n?=?12). Results There was no significant difference in the proportion of tall columnar cells showing CFTR immunostaining as a discrete band at the apical membrane in cells harbouring the CFTR-delF508 mutation compared to non-CF cells (p?=?0.21, n?=?12). However, the amount of CFTR expressed at the apical surface was reduced by ?50% in CF cells compared to non-CF cells (p?=?0.04, n?=?5). Conclusions Our novel observation challenges the prevailing paradigm that CFTR is essentially absent from the apical membrane of respiratory cells harbouring the CFTR-delF508 mutation. Moreover, it raises the possibility that the new generation of CFTR potentiators may offer a realistic therapeutic option for CF patients.

Borthwick, Lee A.; Botha, Phil; Verdon, Bernard; Brodlie, Malcolm J.; Gardner, Aaron; Bourn, David; Johnson, Gail E.

2011-01-01

406

A chemical corrector modifies the channel function of F508del-CFTR.  

PubMed

The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing the biosynthetic defect in F508del-CFTR, thereby permitting its functional expression at the cell surface. The mechanism of action of chemical correctors remains unclear, but it has been suggested that certain correctors [including 4-cyclohexyloxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-325)] may act to promote trafficking by interacting directly with the mutant protein. To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hydroxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-186)], caused a modest but significant inhibition of cAMP-mediated halide flux. Furthermore, VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR in our ATPase activity assay, an effect that may account for the decrease in channel activity by temperature-rescued F508del-CFTR. These findings suggest that biosynthetic rescue mediated by VRT-325 may be conferred (at least in part) by direct modification of the structure of the mutant protein, leading to a decrease in its ATP-dependent conformational dynamics. Therefore, the challenge for therapy discovery will be the design of small molecules that bind to promote biosynthetic maturation of the major mutant without compromising its activity in vivo. PMID:20501743

Kim Chiaw, Patrick; Wellhauser, Leigh; Huan, Ling Jun; Ramjeesingh, Mohabir; Bear, Christine E

2010-09-01

407

DelsGate, a robust and rapid gene deletion construction method.  

PubMed

With the increasing availability of fungal genome sequences there is great demand for fast, simple high-throughput methods to generate constructs for gene deletion. Here we describe a method that combines PCR and Gateway cloning technology together with use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. These constructs are then used to produce deletion mutants in the organism of interest following applicable methods for that species. In establishing this protocol we determined empirically that 1 kb was a suitable flank length to facilitate homologous recombination in our species of interest, Ustilago maydis. The method, which we have named DelsGate (Deletions via Gateway), consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for transformation of Ascomycetes and the Basidiomycete fungus U. maydis which causes corn smut disease. We have tested the reproducibility of the DelsGate approach by generating deletion constructs for 12 U. maydis genes. Although not tested here, the PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. DelsGate has the potential to be universal for all organisms with efficient transformation and homologous recombination systems. PMID:18248826

García-Pedrajas, María D; Nadal, Marina; Kapa, Laura B; Perlin, Michael H; Andrews, David L; Gold, Scott E

2008-04-01

408

Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico  

NASA Astrophysics Data System (ADS)

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la investigacion se utilizo una metodologia cuantitativa y la herramienta para lograrlo fue una encuesta. La encuesta se analizo estadisticamente mediante analisis de frecuencias y por cientos, prueba ANOVA, prueba t, pruebas Post Hoc de Tukey y de Levene. Tambien se realizo nuevamente una prueba de confiabilidad mediante el alfa de Cronbach. Los resultados reflejaron que los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Ciencias Naturales, Educacion, Humanidades, Estudios Generales y el Departamento de Ciencias Biologicas tienen una percepcion muy positiva del concepto de cultura cientifica, los contenidos curriculares de Ciencias Biologicas y del nuevo bachillerato.

Ramos Pastrana, Nilsa

409

Yeast DEL Assay Detects Protection against Radiation-Induced Cytotoxicity and Genotoxicity: Adaptation of a Microtiter Plate Version  

PubMed Central

The DEL assay in yeast detects DNA deletions that are inducible by many carcinogens. Here we use the colorimetric agent MTS to adapt the yeast DEL assay for microwell plate measurement of ionizing radiation-induced cell killing and DNA deletions. Using the microwell-based DEL assay, cell killing and genotoxic DNA deletions both increased with radiation dose between 0 and 2000 Gy. We used the microwell-based DEL assay to assess the effectiveness of varying concentrations of five different radioprotectors, N-acetyl-l-cysteine, l-ascorbic acid, DMSO, Tempol and Amifostine, and one radiosensitizer, 5-bromo-2-deoxyuridine. The microwell format of the DEL assay was able to successfully detect protection against and sensitization to both radiation-induced cytotoxicity and genotoxicity. Such radioprotection and sensitization detected by the micro-well-based DEL assay was validated and compared with similar measurements made using the traditional agar-based assay format. The yeast DEL assay in microwell format is an effective tool for rapidly detecting chemical protectors and sensitizers to ionizing radiation and is automatable for chemical high-throughput screening purposes.

Hafer, Kurt; Rivina, Yelena; Schiestl, Robert H.

2010-01-01

410

Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.  

PubMed

Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking of F508del CFTR may overcome this defect; however, the rescued F508del CFTR still displays reduced chloride permeability. Therefore, a combined administration of correctors and potentiators of the gating defect is ideal. We recently found that 4,6,4'-trimethylangelicin (TMA), besides inhibiting the expression of the IL-8 gene in airway cells in which the inflammatory response was challenged with Pseudomonas aeruginosa, also potentiates the cAMP/PKA-dependent activation of wild-type CFTR or F508del CFTR that has been restored to the plasma membrane. Here, we demonstrate that long preincubation with nanomolar concentrations of TMA is able to effectively rescue both F508del CFTR-dependent chloride secretion and F508del CFTR cell surface expression in both primary or secondary airway cell monolayers homozygous for F508del mutation. The correction effect of TMA seems to be selective for CFTR and persisted for 24 h after washout. Altogether, the results suggest that TMA, besides its anti-inflammatory and potentiator activities, also displays corrector properties. PMID:24816489

Favia, Maria; Mancini, Maria T; Bezzerri, Valentino; Guerra, Lorenzo; Laselva, Onofrio; Abbattiscianni, Anna C; Debellis, Lucantonio; Reshkin, Stephan J; Gambari, Roberto; Cabrini, Giulio; Casavola, Valeria

2014-07-01

411

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.  

PubMed

The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency. PMID:23652375

Huijts, Petra E A; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly M M; Wijnen, Juul; Berns, Els M J J; Martens, John W M; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob A E M; Devilee, Peter; van Asperen, Christi J

2014-01-01

412

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1  

PubMed Central

Misfolding and degradation of CFTR is the cause of disease in patients with the most prevalent CFTR mutation, an in-frame deletion of phenylalanine (F508del), located in the first nucleotide-binding domain of human CFTR (hNBD1). Studies of (F508del)CFTR cellular folding suggest that both intra- and inter-domain folding is impaired. (F508del)CFTR is a temperature-sensitive mutant, that is, lowering growth temperature, improves both export, and plasma membrane residence times. Yet, paradoxically, F508del does not alter the fold of isolated hNBD1 nor did it seem to perturb its unfolding transition in previous isothermal chemical denaturation studies. We therefore studied the in vitro thermal unfolding of matched hNBD1 constructs ±F508del to shed light on the defective folding mechanism and the basis for the thermal instability of (F508del)CFTR. Using primarily differential scanning calorimetry (DSC) and circular dichroism, we show for all hNBD1 pairs studied, that F508del lowers the unfolding transition temperature (Tm) by 6–7°C and that unfolding occurs via a kinetically-controlled, irreversible transition in isolated monomers. A thermal unfolding mechanism is derived from nonlinear least squares fitting of comprehensive DSC data sets. All data are consistent with a simple three-state thermal unfolding mechanism for hNBD1 ± F508del: N(±MgATP) ? IT(±MgATP) ? AT ? (AT)n. The equilibrium unfolding to intermediate, IT, is followed by the rate-determining, irreversible formation of a partially folded, aggregation-prone, monomeric state, AT, for which aggregation to (AT)n and further unfolding occur with no detectable heat change. Fitted parameters indicate that F508del thermodynamically destabilizes the native state, N, and accelerates the formation of AT.

Protasevich, Irina; Yang, Zhengrong; Wang, Chi; Atwell, Shane; Zhao, Xun; Emtage, Spencer; Wetmore, Diana; Hunt, John F; Brouillette, Christie G

2010-01-01

413

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.  

PubMed

Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal response or lose one. This heterogeneity could be attributed to the presence of human organic cation transporter-1 (hOCT1) single nucleotide polymorphisms (SNPs). In the present study, we analyzed the effect of 23 hOCT1 SNPs on imatinib treatment outcome in newly diagnosed CML patients using MassARRAY sequencing and pyrosequencing. The only SNP associated with outcome was M420del (rs35191146), with patients with the M420del demonstrating an increased probability of imatinib treatment failure. In CML cell lines transfected with M420del and/or M408V, M420del significantly decreased imatinib uptake, but this effect was countered if the M408V (rs628031) SNP was also present. A similar effect was seen for the uptake of the hOCT1 substrates TEA(+) and ASP(+). Finally, apparent hOCT1 mRNA levels were studied using both our earlier primers covering the M420del and another set that did not. Different mRNA expression was observed, explaining the disparity in published data on the prognostic importance of hOCT1 mRNA and highlighting the importance of avoiding common SNP sites in primer design. These data demonstrate that the common M420del SNP can modulate the outcome of imatinib treatment. PMID:23223357

Giannoudis, Athina; Wang, Lihui; Jorgensen, Andrea L; Xinarianos, George; Davies, Andrea; Pushpakom, Sudeep; Liloglou, Triantafilos; Zhang, Jieying-Eunice; Austin, Gemma; Holyoake, Tessa L; Foroni, Letizia; Kottaridis, Panagiotis D; Müller, Martin C; Pirmohamed, Munir; Clark, Richard E

2013-01-24

414

Physiological profile of fighters influences training organisation in combat sports: response to Del Vecchio, Hirata, and Franchini (2011).  

PubMed

The article by Del Vecchio, et al. (2011) provides relevant information to trainers about the effort-pause ratio during mixed martial arts matches. Taking into account the physiological profiles of fighters would increase interest in these findings. PMID:22403925

Paillard, Thierry

2011-12-01

415

Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis.  

PubMed

To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted a meta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphism was associated with cancer risk in the pooled analysis and in Asian population, whereas no association was observed in Caucasian population. Stratified analysis by subtypes of cancer showed that the -94ins/del polymorphism was associated with oral squamous cell carcinoma and ovarian cancer risk, but had no association with colorectal cancer, bladder cancer, and renal cell cancer. Our meta-analysis suggests the NFKB1 -94ins/del polymorphism affects cancer susceptibility, and the association is ethnic-specific. PMID:24827594

Duan, Wenyuan; Wang, Erli; Zhang, Fengquan; Wang, Tongjian; You, Xiangdong; Qiao, Bin

2014-08-01

416

Los Alamos National Laboratory (USA): Instituto Mexicano Del Petroleo Cooperative Program for the ASPEN Flowsheet Simulator: Status Report.  

National Technical Information Service (NTIS)

On June 20, 1983, the Los Alamos National Laboratory, the US Department of Energy, and the Instituto Mexicano del Petroleo (IMP) signed a Memorandum of Understanding (MOU) that established a program of cooperation between the Los Alamos National Laborator...

T. T. Phillips

1987-01-01

417

CHEK2 1100 delC mutation in Russian ovarian cancer patients.  

PubMed

BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers. PMID:19725991

Krylova, Nadezhda Yu; Ponomariova, Daria N; Sherina, Natalia Yu; Ogorodnikova, Natalia Yu; Logvinov, Denis A; Porhanova, Natalia V; Lobeiko, Oksana S; Urmancheyeva, Adel F; Maximov, Sergey Ya; Togo, Alexandr V; Suspitsin, Evgeny N; Imyanitov, Evgeny N

2007-01-01

418

CHEK2 1100 delC mutation in Russian ovarian cancer patients  

PubMed Central

BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers.

Krylova, Nadezhda Yu; Ponomariova, Daria N; Sherina, Natalia Yu; Ogorodnikova, Natalia Yu; Logvinov, Denis A; Porhanova, Natalia V; Lobeiko, Oksana S; Urmancheyeva, Adel F; Maximov, Sergey Ya; Togo, Alexandr V; Suspitsin, Evgeny N; Imyanitov, Evgeny N

2007-01-01

419

Incentivos para atraer y retener personal de salud de zonas rurales del Per?: un estudio cualitativo  

PubMed Central

El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado.

Huicho, Luis; Canseco, Francisco Diez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andres G.

2014-01-01

420

A Neandertal mandible from the Cova del Gegant (Sitges, Barcelona, Spain).  

PubMed

A human mandible from the site of Cova del Gegant is described here for the first time and compared with other Middle and Upper Pleistocene representatives of the genus Homo from Europe and Southwest Asia. The specimen was recovered from sediments which also yielded Mousterian stone tools and Pleistocene fauna. The preserved morphology of the mandible, particularly in the region of the mental foramen, clearly aligns it with the Neandertals, making the Cova del Gegant the only known site in Catalonia documenting diagnostic human skeletal remains in association with Middle Paleolithic stone tools. This represents an important new addition to the human fossil record from the Iberian Peninsula and joins the Bañolas mandible in documenting the course of human evolution in the northern Mediterranean region of Spain. PMID:15896823

Daura, J; Sanz, M; Subirá, M E; Quam, R; Fullola, J M; Arsuaga, J L

2005-07-01

421

Topological open string amplitudes on local toric del Pezzo surfaces via remodeling the B-model  

NASA Astrophysics Data System (ADS)

We study topological strings on local toric del Pezzo surfaces by a method called remodeling the B-model which was recently proposed by Bouchard, Klemm, Mariño and Pasquetti. For a large class of local toric del Pezzo surfaces we prove a functional formula of the Bergman kernel which is the basic constituent of the topological string amplitudes by the topological recursion relation of Eynard and Orantin. Because this formula is written as a functional of the period, we can obtain the topological string amplitudes at any point of the moduli space by a simple change of variables of the Picard-Fuchs equations for the period. By this formula and mirror symmetry we compute the A-model amplitudes on KF_2, and predict the open orbifold Gromov-Witten invariants of C/Z.

Manabe, Masahide

2009-09-01

422

Datos sobre la biometría del Pájaro moscón (Remiz pendulinus) en la provincia de Alicante (SE de España)  

Microsoft Academic Search

Aquesta nota presenta dades biomètriques sobre la longitud de l'ala i el pes del teixidor en una localitat d'hivernada de la provincia d'Alacant. Es va obtenir una mitjana de la longitud de l'ala de 55,88 mm (SD= 1,85; n= 51), amb un rang de 51-60 mm. La mitjana del pes va ser 9,33 g (SD=0,52; n=51) (8-10,5). No es van

Ignacio García Peiró

1991-01-01

423

Quaternary eruptive history and hazard-zone model at Nevado del Tolima and Cerro Machin volcanoes, Colombia  

Microsoft Academic Search

The ice-clad and fumarolic Nevado del Tourna volcano (4 ° 39?N, 75 ° 20?W) south of Nevado del Ruiz, is offset toward the southeast from the axis of the volcanic Ruiz-Tolima massif with respect to the major NE-trending strike-slip Palestina fault. It is composed of four units: (1) a pre-Tolima plateau-like basement of basaltic andesite lava flows of early Quaternary

J. C. Thouret; J. M. Cantagrel; C. Robin; A. Murcia; R. Salinas; H. Cepeda

1995-01-01

424

Frequency of the CHEK2 1100delC Mutation among Women with Breast Cancer: An International Study  

Microsoft Academic Search

A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranean. The frequency of the 1100delC allele has not been

Shiyu Zhang; Catherine M. Phelan; Phil Zhang; Francois Rousseau; Parviz Ghadirian; William Foulkes; Nancy Hamel; David McCready; Maureen Trudeau; Henry Lynch; Douglas Horsman; Zeba Aziz; Magda Gomes; Mauricio Magalhaes Costa; Alexander Liede; Aletta Poll; Ping Sun; Steven A. Narod

425

OSSERVAZIONE CON TECNICA E.S.P.I. DEL COMPORTAMENTO A COMPRESSIONE DI MATERIALI QUASI-FRAGILI  

Microsoft Academic Search

Oggetto di questo lavoro è il perfezionamento di una tecnica interferometrica a luce laser E.S.P.I. per lo studio del comportamento a compressione di materiali quasi-fragili. Per lo sviluppo del sistema E.S.P.I. sono state effettuate prove di compressione su campioni prismatici in gasbeton, un particolare conglomerato aerato. Per misurare gli spostamenti verticali della superficie dei campioni, il setup E.S.P.I. è stato

Eva Coïsson; Daniele Ferretti

426

CARACTERIZACIÓN DE LA DUCTILIDAD Y DEL COMPORTAMIENTO MECÁNICO A VELOCIDAD DE DEFORMACIÓN VARIABLE DE HORMIGONES DE ALTA RESISTENCIA  

Microsoft Academic Search

Resumen. Este trabajo trata sobre el comportamiento mecánico del hormigón de alta resistencia cuando se ensa- ya a compresión y en control de deformación. Los ensayos se realizan a cuatro velocidades de deformación dife- rentes, en el rango de 1.5x10 -3 a 5.0x10 -8 s -1 . Los resultados obtenidos permiten cuantificar la ductilidad del ma- terial. Por ejemplo, la

G. Ruiz; J. R. Del Viso; J. R. Carmona

2006-01-01

427

Aberrant RNA splicing in RHD 7-9 exons of DEL individuals in Taiwan: A mechanism study  

Microsoft Academic Search

BackgroundThe Rh blood D group provides a clinically important model of aberrant splicing with skipped exons. Approximately 30% of serologically D-negative Chinese individuals have an intact RHD gene (DEL phenotype) and induce allo-immunization in transfusions. The RHD1227GNA polymorphism occurs in >95% DEL phenotype of Asian descent. The effects of RHD 1227A and a novel allele on exon 9 splicing were

Hsiang-Chun Liu; Hock-Liew Eng; Yu-Fen Yang; Ya-Hui Wang; Kuan-Tsou Lin; Hua-Lin Wu; Tsun-Mei Lin

2010-01-01

428

Spectroscopic Observation of Nova Del 2013 with the 2.6m Telescope of the Crimean Astrophysical Observatory  

NASA Astrophysics Data System (ADS)

We obtained low resolution spectra (R~1000) of Nova Del 2013 on August 15.8 UT using Nesmith spectrograph attached to the 2.6m telescope of the Crimean Astrophysical Observatory (Nauchny, Ukraine). The spectral observation were performed in the region 3470-7575 A. The spectra display that Nova Del 2013 is still in the fireball stage as mention Darnley et al. (ATEL 5279) and Shore et al. (ATEL 5282).

Tarasova, T. N.

2013-08-01

429

Chemostratigraphy of the Lower Arroyo del Soldado Group (Vendian, Uruguay) and Palaeoclimatic Implications  

Microsoft Academic Search

New C- and O-isotopic determinations from the Vendian lower Arroyo del Soldado Group are reported and combined with sedimentologic and biostratigraphic data. On the basis of different geochemical and petrographic criteria, the primary nature of the C- and Sr-isotopic signature is shown. Positive d13C-values characterize the mainly siliciclastic upper Yerbal Formation, which contains oxide-facies BIF and a diverse assemblage of

Claudio Gaucher; Alcides Nóbrega Sial; Gonzalo Blanco; Peter Sprechmann

2004-01-01

430

Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel  

Cancer.gov

Está bien pasar algún tiempo en el sol, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.

431

Physical, morphological and chemical characteristics, oil recovery and fatty acid composition of Balanites aegyptiaca Del. kernels  

Microsoft Academic Search

Balanites aegyptiaca Del. kernels were chemically,physically and morphologically characterized. Crude oil (49.0%) andcrude protein (32.4%) were the two major constituents of the kernels.Phytic acid content was relatively high compared to other legumes. Incontrast, antitryptic activities of the kernel flours were very low.Sapogenin contents of the full fat, defatted and testa flours were 1.5, 2.7and 3.0%, respectively. The hardness of the

A. M. Mohamed; W. Wolf; W. E. L. Spieß

2002-01-01

432

Observación y registro fotográfico del cometa HYAKUTAKE C/1996 B2  

NASA Astrophysics Data System (ADS)

Desde el momento en que nos llega la información del descubrimiento, comenzamos la observación de forma detallada a fin de apreciar y seguir su creciente actividad. La primera observación se realizó el 17 de febrero de 1996 a las 4h20m UT con nuestro telescopio de 300mm newtoniano de f/6.5, con una muy buena transparencia atmosférica, estimando una magnitud de 8.5. Realizábamos observaciones casi todas las noches, mientras nos lo permitían las condiciones climáticas. Ya el 26 de febrero el cometa presentaba un aspecto muy particular, ligeramente distinto a las primeras observaciones, ya que comenzamos a notar su gran actividad. En primer lugar se destacaba la cola de iones mucho mas extensa que la cola de polvo. Magnitud estimada 7.5. El 19 de marzo ya era visible a simple vista y en especial su cola muy abierta y extensa (3 grados) y no quedaba duda alguna que la última noche de observación del cometa en el horizonte de la Ciudad de Funes, que fue el 24 de marzo de 1996, un día antes del acercamiento a la Tierra, tendríamos una apreciación del cometa en su máximo esplendor. El 24 de marzo de 1996 a las 4hs UT, asomó el cometa por el horizonte NE, con su cola espectacular, llegando a medir 23 grados de longitud, muy recta y brillante, y su cabellera muy estelar. A este marco de observación se sumaron mas de 600 personas que participaron usando instrumentos, siendo la mayoría de los concurrentes de la vecina Ciudad de Rosario, ya que su observación era a muy baja atura sobre el horizonte norte. Instrumentos utilizados : Telescopio Newtoniano 300mm f/6.5, Telescopio Schmidt-Cassegrain 200mm , Binoculares 10 x 50, 7 x 50, Lente normal 50mm a f/1.8, Película 100 - 400 ASA Lugar de Observación : Ciudad de Funes, zona rural, ``Estancia La Polola" Latitud: - 32o 55' Longitud: 60o 40' Oeste

Arquiola, A. P.; Arquiola, F. E.

433

Brand extension nelle imprese di servizi sportivi: opportunità ed implicazioni manageriali nel caso del calcio  

Microsoft Academic Search

L’obiettivo del lavoro è di definire le opportunità e le implicazioni manageriali connaturate all’implementazione di strategie di sfruttamento dei brand all’interno delle imprese di servizi sportivi. L’interesse nei confronti delle strategie di brand discende da un lato dalla necessità per le imprese sportive di diversificare le proprie attività e di svincolare le performance economiche dai risultati sul campo e, dall’altro,

Tommasina Pianese

2010-01-01

434

Life to 450 m depth at Isla del Coco, Costa Rica  

Microsoft Academic Search

Isla del Coco is the summit of a seamount 500 km southwest of Costa Rica's mainland. The island is surrounded by a platform about 18 km long that trends in a southwest-northeast direction with a break in slope at around 180 m deep. Since 2006 the DeepSee submarine, with a 450 m depth capability, has been exploring the deep-water environments

Jorge Cortés; Shmulik Blum

435

Evaluacion de proceso del programa de educacion afectivo-sexual Ni ogros ni princesas.  

PubMed

RESUMEN Fundamento: En 2008, se puso en marcha el programa Ni ogros ni princesas en 12 centros de secundaria de Asturias (España) para incorporar la educación afectivo-sexual. El programa proponía 14 actividades, dirigidas a alumnado, profesorado y familias. Este estudio recoge la evaluación de proceso de esta intervención, en relación a la ejecución de las actividades, participación, satisfacción, utilidad percibida y propuestas de mejora. Métodos: La población de estudio fueron los 12 centros que participaron en el programa, y su alumnado, profesorado y familias. Se obtuvo información sobre la ejecución de actividades mediante un cuestionario de seguimiento; se recogió la satisfacción y utilidad percibida con cuestionarios auto-administrados para alumnado y profesorado; también se recogieron sus propuestas de mejora, y las de las familias, en grupos focales. Resultados: El número medio de actividades realizadas por los 12 centros fue 11,6. Se implicaron 185 docentes (26%), que impartieron sesiones al 81% del alumnado en estos 12 centros. El número medio de sesiones impartidas fue 6 en cada nivel de la ESO. El 79% del profesorado se sintió bastante/muy satisfecho con su actuación y al 65% del alumnado le gustaron bastante/mucho estas sesiones. Más del 60% de estudiantes y docentes consideraron que estas sesiones servían bastante/mucho para aumentar conocimientos, reflexionar, mejorar la igualdad, conocer otras opiniones y favorecer el respeto a la diversidad sexual. Entre las propuestas de mejora, más horas para la educación sexual, liberación horaria para el profesorado, y más actividades para familias. Conclusiones: El programa fue una intervención novedosa y percibida como útil para incorporar la educación sexual en los centros de secundaria, ya que contó con un gran nivel de ejecución, así como una alta participación, satisfacción y utilidad percibida por el alumnado y profesorado. PMID:24801790

García-Vázquez, Jose; Ordóñez, Adelina Lena; Alvarez, Y Óscar Suárez

2012-06-01

436

GIS based Relative Tsunami Hazard Maps for Northern California, Humboldt and Del Norte Counties  

Microsoft Academic Search

Tsunami hazard maps are generated using a geographical information systems (GIS) approach to depict the relative tsunami hazard of coastal Humboldt and Del Norte Counties in northern California. Maps are composed for the Humboldt Bay, Eel River, and Crescent City regions and available online at http:\\/\\/www.humboldt.edu\\/~geodept\\/earthquakes\\/rctwg\\/toc.html . In contrast to previous mapping efforts that utilize a single line to represent

J. R. Patton; L. A. Dengler

2004-01-01

437

Isolation and assessment of phytate-hydrolysing bacteria from the DelMarVa Peninsula  

Microsoft Academic Search

Summary The Delaware-Maryland-Virginia (DelMarVa) Penin- sula, flanking one side of the Chesapeake Bay, is home to a substantial broiler chicken industry. As such, it produces a significant amount of manure that is typically composted and spread onto local crop- lands as a fertilizer. Phytate (myo inositol hexak- isphosphate), the major form of organic phosphorus in the manure, can be hydrolysed

Jane E. Hill; David Kysela; Menachem Elimelech

2007-01-01

438

Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel  

Cancer.gov

Está bien pasar algún tiempo al aire libre, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.

439

Estudio semiótico de El embrujado de Ramón del Valle-Inclán  

Microsoft Academic Search

El embrujado by Ramón del Valle-Inclán, published first in 1913, did not enjoy a positive reception from the public and the critics. The play was not actually produced\\u000a on stage until 1931 by the Teatro Muñoz Seca. Even though critical reception was a bit more positive this time, the play did\\u000a not achieve great public success. This essay constitutes a

Inma Cívico Lyons

2011-01-01

440

Optimización mediante algoritmos genéticos de la gestión del agua en el regadío  

Microsoft Academic Search

El uso de un recurso como el agua, esencial y escaso, tiene gran trascendencia ambiental, social, económica,\\u000apolítica, etc., siendo su adecuada gestión fundamental para conseguir la sostenibilidad de sus aprovechamientos.\\u000aPara alcanzar ese objetivo, la agricultura actual necesita modelos de ayuda a la toma de decisiones para\\u000ala gestión y explotación agrícola.\\u000aSe presenta un modelo de optimización del

Pedro Carrión; Eulogio López; José Fernando Ortega; Arturo de Juan

1970-01-01

441

An Accretion Disc Model For Algol Type Eclipsing Binary System: AV Del  

Microsoft Academic Search

We inspect the light and radial-velocity curves of the eclipsing binary AV\\u000aDel. Using the most new version of Wilson - Devinney (1971) code (for more\\u000ainformation please see Wilson - Wan Hamme, 2003), the absolute elements,\\u000afundamental orbital and physical parameters of the system are determined. Using\\u000athese parameters the configuration of the system are presented. Then, using the

Sayyed Mohammad Reza Ghoreyshi; Jamshid Ghanbari; Fatemeh Salehi

2008-01-01

442

Antimicrobial activity of flavonoids in medicinal plants from Tafí del Valle (Tucumán, Argentina).  

PubMed

Preliminary studies of flavonoids have been realised in five native species from Tafí del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The total extracts of flavonoids of each plant were tested and four species studied showed antimicrobial activity. PMID:11025172

Hernández, N E; Tereschuk, M L; Abdala, L R

2000-11-01

443

Análisis geométrico de localización del modelo elastoplástico parabólico de Drucker-Prager dependiente de gradientes  

Microsoft Academic Search

En este trabajo se presenta el método geométrico para el análisis de las propiedades de localización del modelo\\u000aelastoplástico parabólico de Drucker-Prager dependiente de gradientes. El modelo es termodinámicamente\\u000aconsistente. A partir de la solución de la condición de bifurcación discontinua de la elastoplasticidad dependiente\\u000ade gradientes para pequeñas deformaciones, se formula la elipse de localización en las coordenadas\\u000ade

Sonia Mariel Vrech; Guillermo Etse

1970-01-01

444

Red de Investigación del Cáncer de los Estados Unidos y América Latina  

Cancer.gov

El estado general de la infraestructura de capacidad y apoyo de la investigación y desarrollo tanto de investigación como del ejercicio de la atención médica es bastante diversa en América Latina. Algunos países latinoamericanos con diferentes niveles capacidad de investigación y de ejercicio de la atención médica se han unido a la Oficina para el Desarrollo de Programas de Cáncer en América Latina para formar la Red de Investigación de Cáncer de los Estados Unidos y América Latina.

445

Experience the magic of light and color: outreach activity by Universidad del Valle student chapter  

NASA Astrophysics Data System (ADS)

During 2007, the Universidad del Valle Student Chapter presented a proposal for developing an educational outreach activity for children from an underprivileged zone to the Optical Society of America Foundation (OSAF) and to SPIE. The activity was carried out jointly by OSA and SPIE Universidad del Valle Student Chapters in the hillsides of Santiago de Cali, in a zone known as "Pueblo Joven" during 2008. It was aimed to boys and girls with ages between 8 and 13 years and was called "Experience the magic of light and color". The main purpose was to bring the children some basic concepts on optics and to encourage them to explore science through optics. The Universidad del Valle Student Chapters designed a series of talks and practical workshops where children participated in hands-on experiments that easily explain the fundamental concepts of light phenomena. Afterwards the children presented their achievements in a small science fair offered to the community and tried to explain in their own words what they learned and built. In this work, we present the most successful experimental designs and the educational standards we tried to develop with this activity.

Valdes, Claudia; Reyes, Camilo; Osorio, Alberto; Solarte, Efrain

2010-08-01

446

[Seventy years of medicine in the Instituto Mexicano del Seguro Social].  

PubMed

The purpose of these lines is to remember and refer some of the historical landmarks in the evolution of the medical services of the Instituto Mexicano del Seguro Social (IMSS, according to its initials in Spanish) since it was founded, in 1943. We also want to bring to the reader's attention that the dimensions and impacts on health that IMSS has achieved, throughout its history, have strengthened the citizenship, as well as social sustainability. Also, those impacts have determined the creation and the reinforcement of human capital in México. Throughout this concise balance, all the controversy surrounding the foundation of the Institute is being recalled (the protest in the Mexico City Zócalo, or the attack to an hospital in San Ángel -a neighborhood located in the Southwest of Mexico City-), as well as the way the IMSS incorporated several words into the vocabulary of Mexicans. We also remember the previous antecedent of the Revista Médica del Instituto Mexicano del Seguro Social, as well as the Revista de Enfermería, and the emblematic Archives of Medical Research. The IMSS has 70 years of achievements, seven decades covered. PMID:24758865

Fajardo-Ortiz, Guillermo

2014-01-01

447

A Precambrian cratonic block in the west-central Chihuahua - The Sierra del Nido cratonic block  

SciTech Connect

Precambrian rocks in west-central Chihuahua have been recognized by Denison (1969) and Mauger et al. (1983), on the basis of radiometric dating. The rocks are rhyolite clasts, and an allucthonous block, respectively, however their source direction and vergence can be measured. They point back to and are on the edge of a large, uniform, negative Bouguer gravity anomaly, having values greater than 200 milligals. The isotopic geochemical character of several Tertiary felsic fields within this anomalous are has been determined, and initial strontium isotopic ratios are all greater than 0.7055. Outside the anomalous area these ratios are lower, and Basin and Range extension tectonism is more evident. It is proposed that a Precambrian cratonic block, the Sierra del Nido, is present in the crust in west-central Chihuahua. It is reasonable to propose that it was decreted from North America during a Precambrian extensional (1.1. By ) event, from somewhere along the Arizona Transition Zone-Texas Linament region. The Sierra del Nido Block is separated form the ATZ-TL by a region of disrupted craton and extended crust, the Basin and Range Province. Implications of the pressure of the Sierra del Nido Block on other regional tectonic events will be discussed.

Goodell, P.C. (Univ. of Texas, El Paso, TX (United States). Dept. of Geological)

1993-02-01

448

Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama  

USGS Publications Warehouse

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

Lovelock, C. E.; Feller, I. C.; McKee, K. L.; Thompson, R.

2005-01-01

449

Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.  

PubMed

Cystic fibrosis (CF) is an inherited, life-threatening disease caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), an ABC transporter-class protein and ion channel that transports ions across epithelial cell membranes. The most common mutation leads to the deletion of a single phenylalanine, and the resulting protein, F508del-CFTR, shows reduced trafficking to the membrane and defective channel gating. The ideal therapeutic approach would address both of these defects and restore channel function at the same time. We describe here the application of a combination high-throughput screening to search for synergistic modulators of F508del-CFTR. With the adapted Fischer rat thyroid-yellow fluorescent protein halide flux assay to the combination high-throughput screening platform, we identified many interesting single agents as CFTR modulators from a library of approved drugs and mechanistic probe compounds, and combinations that synergistically modulate F508del-CFTR channel function in Fischer rat thyroid cells, demonstrating the potential for combination therapeutics to address the defects that cause CF. PMID:21050065

Lin, Stephen; Sui, Jinliang; Cotard, Shakira; Fung, Brenda; Andersen, Jennifer; Zhu, Ping; El Messadi, Najib; Lehar, Joseph; Lee, Margaret; Staunton, Jane

2010-12-01

450

Pampa del Palo: an anomalous composite marine terrace on the uprising coast of southern Peru  

NASA Astrophysics Data System (ADS)

Quaternary sediments along the southern Perúvian coast occur as staircase terraces of coastal and shallow-marine deposits in response to continuous uplift related to the active boundary between the Nazca and South-American plates. However, near ILO (in the same coastal stretch) the emergent Pampa del Palo terrace consists of a relatively-thick, vertical stack of shallow-marine, coastal and lagoonal deposits that indicate a rather different geodynamic behaviour. Coastal deposits are correlatable with the successive marine highstands of isotopic stages 7 (?) and 5 (substages 5e and 5c). Combining aerial photo-interpretation, geomorphological mapping, sedimentological analysis, chronostratigraphical data, and structural observations, the Pampa del Palo feature is interpreted as a faulted block that moved independently of the remaining southern Peruvian coast and, for some time between the end of Middle Pleistocene (before ca. 220 ka) and the early Late Pleistocene (ca. 120 ka), it rose more slowly or was even down-faulted relative to the rest of the southern Peruvian margin. The independent block movements ceased after substage 5e, when the Pampa del Palo "terrace" was incorporated into the regional uplift of the area. Since ca. 100 ka, measured uplift rates in the Ilo area amounted up to {160 mm}/{10 3y } when the area has been affected by a few active, NE-SE trending faults only.

Ortlieb, L.; Zazo, C.; Goy, J. L.; Dabrio, C.; Macharé, J.

1996-11-01

451

DLX3 c.561_562delCT mutation causes attenuated phenotype of tricho-dento-osseous syndrome.  

PubMed

The distal-less homeobox gene DLX3 is expressed in a variety of tissues including placenta, skin, hair, teeth, and bone. Mutation of DLX3 (c.571_574delGGGG) causes the tricho-dento-osseous syndrome (TDO), characterized by abnormal hair, teeth, and bone. Evaluation of a kindred segregating the DLX3 c.561_562delCT mutation revealed distinct changes in the hair, teeth, and bones as has been observed with the DLX3 c.571_574delGGGG mutation. Previously, the DLX3 c.561_562delCT mutation was associated with autosomal dominant amelogenesis imperfecta with taurodontism. The present study shows that the DLX3 c.560_561delCT mutation causes an attenuated TDO phenotype with less severe hair, tooth, and bone manifestations compared with individuals having the DLX3 c.571_574delGGGG mutation. Careful phenotyping of individuals with allelic DLX3 mutations reveals marked differences in phenotypic severity indicating that the carboxy-terminus of the DLX3 protein is critical in determining its function during development in these different tissues. PMID:18203197

Wright, J Timothy; Hong, Sung P; Simmons, Darrin; Daly, Bill; Uebelhart, Daniel; Luder, Hans U

2008-02-01

452

Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis  

PubMed Central

Nuclear factor-?B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism ?94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the ?94ins/del ATTG polymorphism and cancer risk reported conflicting results. To clarify this relationship, we performed a meta-analysis of 21 case-control studies involving 6127 cases and 9238 controls. We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter ?94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). Stratified analyses revealed a significant association between the polymorphism and ovarian, oral, and prostate cancers. Similar results were determined in an Asian population and not in a Caucasian population. Thus, our results suggested that the polymorphism can contribute to cancer risk. Moreover, the polymorphism can exert race- and cancer-specific effects on cancer risk. Further large-scale and functional studies are necessary to elucidate this possible effect.

Tao, Jun; Cao, Qiang; Gu, Jinbao; Deng, Xiaheng; Wang, Jun; Liu, Xuzhong; Wang, Zijie; Wu, Bian; Lu, Qiang; Yin, Changjun

2014-01-01

453

Virus-like attachment sites and plastic CpG islands:landmarks of diversity in plant Del retrotransposons.  

PubMed

Full-length Del elements from ten angiosperm genomes, 5 monocot and 5 dicot, were retrieved and putative attachment (att) sites were identified. In the 2432 Del elements, two types of U5 att sites and a single conserved type of U3 att site were identified. Retroviral att sites confer specificity to the integration process, different att sites types therefore implies lineage specificity. While some features are common to all Del elements, CpG island patterns within the LTRs were particular to lineage specific clusters. All eudicot copies grouped into one single clade while the monocots harbour a more diverse collection of elements. Furthermore, full-length Del elements and truncated copies were unevenly distributed amongst chromosomes. Elements of Del lineage are organized in plants into three clusters and each cluster is composed of elements with distinct LTR features. Our results suggest that the Del lineage efficiently amplified in the monocots and that one branch is probably a newly emerging sub-lineage. Finally, sequences in all groups are under purifying selection. These results show the LTR region is dynamic and important in the evolution of LTR-retrotransposons, we speculate that it is a trigger for retrotransposon diversification. PMID:24849372

Cruz, Guilherme M Q; Metcalfe, Cushla J; de Setta, Nathalia; Cruz, Edgar A O; Vieira, Andréia Prata; Medina, Rosario; Van Sluys, Marie-Anne

2014-01-01

454

Virus-Like Attachment Sites and Plastic CpG Islands: Landmarks of Diversity in Plant Del Retrotransposons  

PubMed Central

Full-length Del elements from ten angiosperm genomes, 5 monocot and 5 dicot, were retrieved and putative attachment (att) sites were identified. In the 2432 Del elements, two types of U5 att sites and a single conserved type of U3 att site were identified. Retroviral att sites confer specificity to the integration process, different att sites types therefore implies lineage specificity. While some features are common to all Del elements, CpG island patterns within the LTRs were particular to lineage specific clusters. All eudicot copies grouped into one single clade while the monocots harbour a more diverse collection of elements. Furthermore, full-length Del elements and truncated copies were unevenly distributed amongst chromosomes. Elements of Del lineage are organized in plants into three clusters and each cluster is composed of elements with distinct LTR features. Our results suggest that the Del lineage efficiently amplified in the monocots and that one branch is probably a newly emerging sub-lineage. Finally, sequences in all groups are under purifying selection. These results show the LTR region is dynamic and important in the evolution of LTR-retrotransposons, we speculate that it is a trigger for retrotransposon diversification.

de Setta, Nathalia; Cruz, Edgar A. O.; Vieira, Andreia Prata; Medina, Rosario; Van Sluys, Marie-Anne

2014-01-01

455

Prevalence of the BRCA1 c.68_69delAG (BIC: 185delAG) mutation in women with breast cancer from north-central Poland and a review of the literature on other regions of the country  

PubMed Central

Aim of the study Germline mutations in BRCA tumor suppressor genes are strongly associated with breast and ovarian cancer. The lifetime risk of these cancers in women with BRCA1 mutation is 84% and 27%, respectively. Studies on the prevalence of BRCA1 c.68_69delAG congenital mutation, the most frequent in Ashkenazi Jews, among women with breast cancer from north-central Poland and review of the literature on other regions of the country. Evaluation of the c.68_69delAG association with breast cancer risk, with respect to women's age at diagnosis and family history of cancer. Material and methods 252 women with breast cancer, without any of the mutations c.5266dupC, c.181T > G, or c.4034delA, regardless of histological type and family history of cancer. The mutation was detected using allele-specific oligonucleotide polymerase chain reaction (ASO-PCR) assay and confirmed by sequence analysis. Results The c.68_69delAG mutation was disclosed in one out of the 252 women (0.4%), who had been diagnosed with breast cancer at age 43. Family investigations revealed the presence of c.68_69delAG also in the patient's mother, diagnosed with breast cancer at age 68. Sequence analysis confirmed the heterozygous status of the mutation, and family investigation its hereditary character. In the group of families with breast cancer history 1.4% frequency of c.68_69delAG was shown. Conclusions Among families with breast cancer aggregation, originating from north-central Poland, c.68_69delAG is a rare BRCA1 alteration, similarly to other central regions of the country, investigated by other authors. However, in northern, north-western and south-western parts of Poland, it occurs 2–4 times more frequently than in our region.

Janiszewska, Hanna; Bak, Aneta; Pilarska, Maria; Heise, Marta; Junkiert-Czarnecka, Anna; Laskowski, Ryszard; Haus, Olga

2013-01-01

456

Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors  

PubMed Central

Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators.

Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J.; de Jonge, Hugo R.

2012-01-01

457

Art pop i curtmetratges a una biblioteca penitenciària: tallers de dinamització cultural a la Biblioteca del Centre Penitenciari de Joves de Barcelona  

Microsoft Academic Search

Es descriuen i s'analitzen dues activitats d'extensió cultural dutes a terme a la Biblioteca del Centre Penitenciari de Joves de Barcelona a partir d'una col·laboració externa. S'inclou una descripció del Centre, de la Biblioteca i del perfil d'usuari a qui s'han dirigit les activats. Seguidament, es resumeixen els diferents passos duts a terme per a la confecció de les activitats,

Laia Castell Padilla; Josep M. Pallisé Carreté; Núria Pedrola i Guillén; Cristina Tomàs i Humbert; Lola Burgos Oliván

2004-01-01

458

The Torres del Paine intrusion as a model for a shallow magma chamber  

NASA Astrophysics Data System (ADS)

The shallow magmatic Torres del Paine Intrusive Complex (TPIC) belongs to a series of sub-volcanic and plutonic igneous bodies in Southern Chile and Argentina. This trench-parallel belt is located in a transitional position between the Patagonia Batholith in the West, and the alkaline Cenozoic plateau lavas in the East. While volumetrically small amounts of magmatism started around 28 my ago in the Torres del Paine area, and a second period occurred between 17-16 Ma, it peaked with the TPIC 12.59-12.43 Ma ago. The spectacular cliffs of the Torres del Paine National park provide a unique opportunity to study the evolution of a very shallow magma chamber and the interaction with its host rocks. Intrusion depth can be estimated based on contact metamorphic assemblages and granite solidus thermobarometry to 750±250 bars, corresponding to an intrusion depth of ca. 3km, ca. 500m above the base of the intrusion. Hornblende thermobarometry in mafic rocks agrees well with these estimates (Leuthold et al., 2014). The TPIC is composed of a granitic laccolith emplaced over 90ka (Michel et al., 2008) in 3 major, several 100m thick sheets, forming an overall thickness of nearly 2 km. Contacts are sharp between sheets, with the oldest sheet on the top and the youngest on the bottom (Michel et al., 2008). The granitic laccolith is under-plated by a ca. 400m thick mafic laccolith, built up over ca. 50ka (Leuthold et al. 2012), constructed from the bottom up. Granitic and mafic sheets are themselves composed of multiple metric to decametric pulses, mostly with ductile contacts between them, resulting in outcrop patterns resembling braided stream sediments. The contact of the TPIC with the Cretaceous flysch sediments document intrusion mechanism. Pre-existing sub-horizontal fold axes are rotated in the roof of the TPIC, clearly demonstrating ballooning of the roof; no ballooning was observed in the footwall of the intrusion. Extension during ballooning of the roof is indicated by dykes emanating from the roof of the intrusion into the host rocks. The dykes are perpendicular to the contact, radially shooting into the country rocks. Since the oldest granite is found in the roof, it is also permeated by dykes of successive intrusions. Contact metamorphism can be used to constrain the granite intrusion temperature to ca. 1000°C. Intrusion occurred in multiple pulses along the granite-host rock contact, in rapid succession, before significant cooling occurred in the aureole. Hydration of the biotite and feldspar of the immature sediments in the outer aureole contributed significantly to the overall thermal signature of the host-rock-TPIC system. In contrast, stable isotopes do not document significant fluid circulation. Leuthold, J., Müntener, O., Baumgartner, L., Putlitz, B., Ovtcharova, M., Schaltegger, U. (2012) Time resolved construction of a granitic to mafic laccolith (Torres del Paine, Patagonia). Earth Plan Sci Lett. 325. 85-92 Leuthold J., Müntener O., Baumgartner L.P., Putlitz B., (2014) Recycling of mafic crystal mush, transport and emplacement in the Torres del Paine mafic complex (Patagonia). J. Petrology; accepted pending revision Michel, J., Baumgartner, L.P. Putlitz, B., Ovtcharova, M., Schaltegger, U. (2008) Incremental growth of a shallow crustal laccolith over 80 kyrs: the Torres del Paine Granite, Patagonia. Geology vol. 36, 459-462

Baumgartner, Lukas; Bodner, Robert; Leuthold, Julien; Muntener, Othmar; Putlitz, Benita; Vennemann, Torsten

2014-05-01

459

Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California  

USGS Publications Warehouse

The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ??18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4??? (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ??18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500??C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center. ?? 1984.

Schiffman, P.; Williams, A. E.; Evarts, R. C.

1984-01-01

460

The imprint of subduction fluids on subducted MORB-derived melts (Sierra del Convento Mélange, Cuba)  

NASA Astrophysics Data System (ADS)

Major and trace element signatures and Sr-Nd-Pb isotope data for muscovite (Ms)-bearing amphibolite blocks and associated muscovite-bearing trondhjemite and quartz-muscovite rocks from the Sierra del Convento mélange (eastern Cuba) indicate that Proto-Caribbean oceanic crust underwent wet partial melting processes during Mesozoic subduction and after accretion to the upper plate. Trace element normalized patterns of Ms-bearing amphibolites are enriched in light rare earth elements (LREE) and large-ion lithophile elements (LILE) and evidence variable trace element transfer from the Proto-Caribbean subducting slab to the mantle wedge. Ms-bearing trondhjemites show LREE enrichment and HREE depletion and have geochemical features similar to adakites, including SiO 2 > 56 wt.%, high Na 2O contents (5.5-9.0 wt.%) and high Sr/Y (16-644). We consider that the trondhjemites represent primary and natural melts formed by deep partial melting of the subducting slab which did not significantly react with the mantle wedge before intrusion in the subduction channel. The Ms-bearing trondhjemites show different geochemical and petrological signatures compared with the Ms-free tonalites-trondhjemites from Sierra del Convento, that are interpreted as primary slab melts. These differences support the idea that partial melting processes in the Sierra del Convento subduction channel were triggered by the infiltration of fluids derived from three distinct subducted sources: sediments, altered mid-ocean ridge basalts (MORB), and serpentinites. In this scenario, the pegmatitic quartz-muscovite rocks, which are highly enriched in LILE, probably represent the crystallization products of fluids derived by differentiation of the trondhjemitic melts.

Lázaro, C.; Blanco-Quintero, I. F.; Marchesi, C.; Bosch, D.; Rojas-Agramonte, Y.; García-Casco, A.

2011-10-01

461

Towards a systematic construction of realistic D-brane models on a del Pezzo singularity  

NASA Astrophysics Data System (ADS)

A systematic approach is followed in order to identify realistic D-brane models at toric del Pezzo singularities. Requiring quark and lepton spectrum and Yukawas from D3 branes and massless hypercharge, we are led to Pati-Salam extensions of the Standard Model. Hierarchies of masses, flavour mixings and control of couplings select higher order del Pezzo singularities, minimising the Higgs sector prefers toric del Pezzos with dP 3 providing the most successful compromise. Then a supersymmetric local string model is presented with the following properties at low energies: (i) the MSSM spectrum plus a local B - L gauge field or additional Higgs fields depending on the breaking pattern, (ii) a realistic hierarchy of quark and lepton masses and (iii) realistic flavour mixing between quark and lepton families with computable CKM and PMNS matrices, and CP violation consistent with observations. In this construction, kinetic terms are diagonal and under calculational control suppressing standard FCNC contributions. Proton decay operators of dimension 4, 5, 6 are suppressed, and gauge couplings can unify depending on the breaking scales from string scales at energies in the range 1012-1016 GeV, consistent with TeV soft-masses from moduli mediated supersymmetry breaking. The GUT scale model corresponds to D3 branes at dP 3 with two copies of the Pati-Salam gauge symmetry SU(4) × SU(2) R × SU(2) L . D-brane instantons generate a non-vanishing ?-term. Right handed sneutrinos can break the B - L symmetry and induce a see-saw mechanism of neutrino masses and R-parity violating operators with observable low-energy implications.

Dolan, Matthew J.; Krippendorf, Sven; Quevedo, Fernando

2011-10-01

462

Lidar Investigation of Atmospheric Stratification: Del=2, 7/3, 23/9 or 3?  

NASA Astrophysics Data System (ADS)

Practically all theories of turbulence assume isotropy or at least local isotropy. In buoyancy driven flows the justification is not obvious because gravity breaks the isotropy yet acts at all scales. The classical assumption is that gravity leads to a basic stably stratified state while simultaneously postulating that the perturbations are nevertheless statistically isotropic. In the atmosphere, the scale height (about 10km) presents a further challenge: isotropic three dimensional turbulence cannot extend to very large scales. The standard model postulates an intermediate "meso-scale gap" followed at larger scales by two dimensional horizontally isotropic turbulence. Today, although we still lack consensus about the full horizontal atmospheric statistics, the meso-scale gap separating the these D=3, D=2 regimes has not been observed and there is wide consensus that the horizontal wind is scaling in the horizontal with spectral exponent ?h =5/3 out to at least several hundred km. In the vertical direction, the spectral exponent ?v > ?h implying scaling stratification with the volume of structures growing at a rate Del=2+ (?h-1)/(?v-1). The two main contending proposals being ?v =11/5 (buoyancy driven, Bolgiano-Obhukov) and ?v =3 (gravity waves, Lumley-Shur) implying Del=7/3, 23/9 respectively. In this talk we describe some recent results using state of the art lidar data of passive scalars, over the range 3m to 120km, we directly estimate Del=2.56±0.05 supporting the 23/9 dimensional "unified scaling" model . We discuss this in relation to other measurement campaigns, and also the implications for modelling the atmosphere. Finally, we show how to make multifractal models of vertical cross-sections which are very close to the data.

Lilley, M.; Lovejoy, S.; Strawbridge, K.; Schertzer, D.

2004-05-01

463

Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon  

SciTech Connect

The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

Coughlin, R.M.; Bement, W.O.; Maloney, W.V. (Pecten International Company, Houston, TX (United States))

1993-09-01

464

F508del-CFTR rescue: a matter of cell stress response.  

PubMed

Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature. PMID:23331026

Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

2013-01-01

465

Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California  

NASA Astrophysics Data System (ADS)

The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ? 18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4‰ (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ? 18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500°C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center.

Schiffman, Peter; Williams, Alan E.; Evarts, Russell C.

1984-10-01

466

Soilscapes in the dynamic tropical environments: The case of Sierra Madre del Sur  

NASA Astrophysics Data System (ADS)

The paper gives an analysis of the pattern of soil cover of the Sierra Madre del Sur, one of the most complex physiographic regions of Mexico. It presents the results of the study of four latitudinal traverses across the region. We show that the distribution of soils in the Sierra Madre del Sur is associated with major climatic gradients, namely by vertical bioclimatic zonality in the mountains and by the effect of mountain shadow. Altitudinal distribution of soil-bioclimatic belts is complex due to non-uniform gradients of temperature and rainfall, and varies with the configuration of the mountain range. The distribution of soils is associated with the erosion and accumulation rates both on mountain slopes and in river valleys. The abundance of poorly developed soils in (semi)arid areas was ascribed to high erosion rate rather than to low pedogenetic potential. The formation of soil mosaic at a larger scale might be ascribed to the complex net of gully erosion and to the system of seismically triggered landslides of various ages. In the valleys, the distribution of soils depends upon the dynamics of sedimentation and erosion, which eventually exposes paleosols. Red-colored clayey sediments are remains of ancient weathering and pedogenesis. Their distribution is associated mainly with the intensity of recent slope processes. The soil cover pattern of the Sierra Madre del Sur cannot be explained by simplified schemes of bioclimatic zonality. The soil ranges can be explained by the distribution of climates, lithology, complex geological history of the region, and recent geomorphological processes.

Krasilnikov, P. V.; García-Calderón, N. E.; Ibáñez-Huerta, A.; Bazán-Mateos, M.; Hernández-Santana, J. R.

2011-12-01

467

Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.  

PubMed

Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

2014-01-01

468

Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.  

PubMed

The F508del mutation impairs trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) to the plasma membrane and results in a partially functional chloride channel that is retained in the endoplasmic reticulum and degraded. We recently used a novel high-throughput screening (HTS) assay to identify small-molecule correctors of F508del CFTR trafficking and found several classes of hits in a screen of 2000 compounds (Carlile et al., 2007). In the present study, we have extended the screen to 42,000 compounds and confirmed sildenafil as a corrector using this assay. We evaluated structural analogs of sildenafil and found that one such molecule called KM11060 (7-chloro-4-{4-[(4-chlorophenyl) sulfonyl] piperazino}quinoline) was surprisingly potent. It partially restored F508del trafficking and increased maturation significantly when baby hamster kidney (BHK) cells were treated with 10 nM for 24 h or 10 muM for 2 h. Partial correction was confirmed by the appearance of mature CFTR in Western blots and by using ha