Science.gov

Sample records for demain quels roles

  1. Des ballons pour demain

    NASA Astrophysics Data System (ADS)

    Régipa, R.

    A partir d'une théorie sur la détermination des formes et des contraintes globales d'un ballon de révolution, ou s'en rapprochant, une nouvelle famille de ballons a été définie. Les ballons actuels, dits de ``forme naturelle'', sont calculés en général pour une tension circonférencielle nulle. Ainsi, pour une mission donnée, la tension longitudinale et la forme de l'enveloppe sont strictement imposées. Les ballons de la nouvelle génération sont globalement cylindriques et leurs pôles sont réunis par un câble axial, chargé de transmettre une partie des efforts depuis le crochet (pôle inférieur), directement au pôle supérieur. De plus, la zone latérale cylindrique est soumise à un faible champ de tensions circonférencielles. Ainsi, deux paramètres permettent de faire évoluer la distribution des tensions et la forme de l'enveloppe: - la tension du câble de liaison entre pôles (ou la longueur de ce câble) - la tension circonférencielle moyenne désirée (ou le rayon du ballon). On peut donc calculer et réaliser: - soit des ballons de forme adaptée, comme les ballons à fond plat pour le bon fonctionnement des montgolfières infrarouge (projet MIR); - soit des ballons optimisés pour une bonne répartition des contraintes et une meilleure utilisation des matériaux d'enveloppe, pour l'ensemble des programmes stratosphériques. Il s'ensuit une économie sensible des coûts de fabrication, une fiabilité accrue du fonctionnement de ces ballons et une rendement opérationnel bien supérieur, permettant entre autres, d'envisager des vols à très haute altitude en matériaux très légers.

  2. Interactions avec des enfants migrants en contexte logopedique: quels etayages? (Interaction with Migrant Children in a Speech Therapy Context: What Kinds of Scaffolding?)

    ERIC Educational Resources Information Center

    Cornali, Sandra Galli

    1998-01-01

    Scaffolding strategies occurring in interactions between speech pathologists and migrant children are discussed. Various contexts and strategies are first defined, and the role of the concept of scaffolding in different types of research is examined. Finally, a corpus of therapist-child interactions is analyzed, focusing on problems of mutual…

  3. ONU Geneve: quel avenir pour le francais? Silence, on coule! (ONU Geneva: What Future for French? Quiet, We're Sinking!)

    ERIC Educational Resources Information Center

    Lebreton, Jean-Michel; And Others

    1986-01-01

    Two articles address change and conflict concerning the French language. One discusses the comparative roles of English and French at the United Nations office in Geneva; the other is in response to the opinions of Philippe de Saint Robert on the need to protect French from change. (MSE)

  4. Challenging Roles

    ERIC Educational Resources Information Center

    Younker, Keith

    2006-01-01

    A veteran teacher with over 35 years experience, the author reflects on the events of September 11, 2001, and how the events of that day demonstrated that teachers fulfill many shifting roles in their students' lives. Here, he shares his own feelings of profound sadness for all the victims on that day, and discusses how the roles of teachers often…

  5. Parents' Role.

    ERIC Educational Resources Information Center

    Hall, George C.

    A psychologist discusses efforts at the Boston Center for Blind Children to help parents adjust to the demands of their multiply-handicapped, visually-impaired children. The following programs are found to be helpful: an infant home visiting program (see EC 062 470)in which parents develop their role through participating in an individualized…

  6. Education, developpment et ecole de demain en Mediterranee (Education, Development and Schools of the Future in the Mediterranean).

    ERIC Educational Resources Information Center

    Sultana, Ronald G.

    2002-01-01

    Offers an analysis of the condition of education in developing countries such as Morocco, where, according to the author, educational improvements will not occur as a result of adopting European educational models. Argues that educational progress in developing regions should embrace humanistic values and be founded upon the concepts of the right…

  7. Genetics of Yeasts

    NASA Astrophysics Data System (ADS)

    Querol, Amparo; Fernández-Espinar, M. Teresa; Belloch, Carmela

    The use of yeasts in biotechnology processes dates back to ancient days. Before 7000 BC, beer was produced in Sumeria. Wine was made in Assyria in 3500 BC, and ancient Rome had over 250 bakeries, which were making leavened bread by 100 BC. And milk has been made into Kefyr and Koumiss in Asia for many centuries (Demain, Phaff, & Kurtzman, 1999). However, the importance of yeast in the food and beverage industries was only realized about 1860, when their role in food manufacturing became evident.

  8. Learning through Role Play.

    ERIC Educational Resources Information Center

    Simmons, Sandra

    2001-01-01

    Explains how role playing can provide enriching experiences that develop children's literacy and numeracy skills. Lists key ingredients of good role playing and suggests ways to plan them and prepare space for them. (SK)

  9. Role Discovery in Graphs

    Energy Science and Technology Software Center (ESTSC)

    2014-08-14

    RolX takes the features from Re-FeX or any other feature matrix as input and outputs role assignments (clusters). The output of RolX is a csv file containing the node-role memberships and a csv file containing the role-feature definitions.

  10. Changing Sex Roles.

    ERIC Educational Resources Information Center

    Worell, Judith

    This article reviews literature on sex role change in children and points to areas which need further research. Competing ideologies which support or reject sex typing of role behaviors are briefly discussed in the introduction. The sources of sex role change are divided into two categories: (1) planned direct intervention programs and (2) natural…

  11. The Advisor's Role

    ERIC Educational Resources Information Center

    Norris, Martha A.

    1975-01-01

    A training program for advisors is presented as a support system for implementing the Open Corridor concept into school systems. The following components of the advisor's role are discussed: selection and training, advisor-teacher relationship, work in the classroom, work with principals and parents, and role of teachers. (EC)

  12. Reconceptualizing Evaluator Roles

    ERIC Educational Resources Information Center

    Skolits, Gary J.; Morrow, Jennifer Ann; Burr, Erin Mehalic

    2009-01-01

    The current evaluation literature tends to conceptualize evaluator roles as a single, overarching orientation toward an evaluation, an orientation largely driven by evaluation methods, models, or stakeholder orientations. Roles identified range from a social transformer or a neutral social scientist to that of an educator or even a power merchant.…

  13. Gender Roles and Coping.

    ERIC Educational Resources Information Center

    Patterson, Joan M.; McCubbin, Hamilton I.

    1984-01-01

    Examined the relationship of gender-role orientation and specific behavioral coping responses of wives (N=82) experiencing a long-term separation from their military spouses. Results showed that an androgynous gender-role orientation was significantly associated with four of the five coping patterns identified as helpful to wives managing a…

  14. Role Playing and Skits

    ERIC Educational Resources Information Center

    Letwin, Robert, Ed.

    1975-01-01

    Explores non-scripted role playing, dialogue role playing, sociodrama, and skits as variations of simulation techniques. Provides step-by-step guidelines for conducting such sessions. Successful Meetings, Bill Communications, Inc., 1422 Chestnut Street, Philadelphia, Pa. 19102. Subscription Rates: yearly (US, Canada, Mexico) $14.00; elsewhere,…

  15. Expanded Roles for HRD.

    ERIC Educational Resources Information Center

    1998

    This document contains three papers from a symposium on expanded roles for human resource development (HRD). "The Roles of Consultants in Gainsharing Firms: Empirical Results" (Eunsang Cho, Gary N. McLean) reports findings that consultants are moderately involved at the separation, preparation, evaluation, and design stages and have low…

  16. Role relationships: lesbian perspectives.

    PubMed

    Lynch, J M; Reilly, M E

    This questionnaire study of 140 lesbians, 70 couples who have lived together for one or more years, explores equality and role relationships. We predicted that lesbians would achieve partnerships characterized by equality and freedom from traditional butch-femme role playing. Financial sharing and decision-making were found to be characterized by high degrees of equality. Household responsibilities tended to be performed individually, but no role-playing was evident. Sexual intimacy items indicated less perceived equality than other areas. And overall, some partners were viewed as unequal. The variables of age, income, education, occupation, assets, and years living together did not explain the inequality observed. PMID:3835202

  17. Dad's Role in Breastfeeding

    MedlinePlus

    ... Text Size Email Print Share Dad's Role in Breastfeeding Page Content Article Body Let’s say you and ... you can be when the time comes. Successful nursing depends on a host of factors, many of ...

  18. Roles within the Family

    MedlinePlus

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  19. The State Role

    ERIC Educational Resources Information Center

    Callan, Patrick M.; Jonsen, Richard W.

    1976-01-01

    Reviews higher education consumer protection activities currently undertaken by the states, with suggestions about others that should be implemented and the role that state coordinating agencies can play in them. (Editor/JT)

  20. Role-Playing Mitosis.

    ERIC Educational Resources Information Center

    Wyn, Mark A.; Stegink, Steven J.

    2000-01-01

    Introduces a role playing activity that actively engages students in the learning process of mitosis. Students play either chromosomes carrying information, or cells in the cell membrane. (Contains 11 references.) (Author/YDS)

  1. The meaning of role strain.

    PubMed

    Ward, C R

    1986-01-01

    Explicating the meaning of the concept of role strain is important in role theory formulation, an area requiring further development to provide explanations and predictions for both patient and provider roles. In this analysis, the use of the term role strain is traced from the structural-functionalist and symbolic-interactionist perspectives. Descriptive, stipulative, and connotative definitions of role strain are derived, and necessary and relevant properties are proposed. Antecedent and intervening conditions for role strain are outlined from the literature. Role strain manifestations and empirical referents are presented, and an initial step is taken toward a theoretical formulation by defining role strain within the context of role stress. PMID:3079985

  2. Teachers' Interpersonal Role Identity

    ERIC Educational Resources Information Center

    van der Want, Anna C.; den Brok, Perry; Beijaard, Douwe; Brekelmans, Mieke; Claessens, Luce C. A.; Pennings, Helena J. M.

    2015-01-01

    This article investigates the link between teachers' appraisal of specific interpersonal situations in classrooms and their more general interpersonal identity standard, which together form their interpersonal role identity. Using semi-structured and video-stimulated interviews, data on teachers' appraisals and interpersonal identity standards…

  3. Adults Role in Bullying

    ERIC Educational Resources Information Center

    Notar, Charles E.; Padgett, Sharon

    2013-01-01

    Do adults play a role in bullying? Do parents, teachers, school staff, and community adult leaders influence bullying behavior in children and teenagers? This article will focus on research regarding all adults who have almost daily contact with children and teens and their part in how bullying is identified, addressed, and prevented. This article…

  4. Roles and Role Conflict of Women in Infertile Couples.

    ERIC Educational Resources Information Center

    Allison, Janet R.

    1979-01-01

    Explores the experience of role conflict for women in infertile couples. Findings lead to an understanding of infertility as part of an interactional system for dealing with potentially intolerable sources of role conflict. (Author)

  5. Neuroendocrine Role for VGF

    PubMed Central

    Lewis, Jo E.; Brameld, John M.; Jethwa, Preeti H.

    2015-01-01

    The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain-derived neurotrophic factor, and glial-derived growth factor. The VGF gene gives rise to a 68 kDa precursor polypeptide, which is induced robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific prohormone convertases in these cells results in the production of a number of smaller peptides. The VGF gene and peptides are widely expressed throughout the brain, particularly in the hypothalamus and hippocampus, in peripheral tissues including the pituitary gland, the adrenal glands, and the pancreas, and in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. VGF peptides have been associated with a number of neuroendocrine roles, and in this review, we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction, and cognition. PMID:25699015

  6. Marital and Family Role Satisfaction

    ERIC Educational Resources Information Center

    Chadwick, Bruce A.; And Others

    1976-01-01

    This paper reports the satisfaction between several independent variables and marital satisfaction. Adequacy of role performance of both self and spouse and spouse's conformity to expectations emerged as the strongest predictors of satisfaction derived from playing family roles. (Author)

  7. The Many Roles of Fatherhood

    PubMed Central

    Henderson, Jim

    1992-01-01

    Recognition of the importance of fathers to children's development is increasing. Fathers play many roles: supporting the mother-infant relationship, nurturing, acting as mother surrogate, encouraging separation and individuation setting up care sexual identify and developing sex role, and encouraging the development of conscience. A fuller understanding of the role of fatherhood can help family physicians offering medical and preventive treatment.

  8. The Division of Family Roles.

    ERIC Educational Resources Information Center

    Ericksen, Julia A.; And Others

    1979-01-01

    Analyzes the marital role division between couples, in the Philadelphia area, concentrating on the division of household tasks, child care, and paid employment. Data support a marital power model with husband's income negatively related and wife's education positively related to shared roles. Blacks are more likely to share roles. (Author)

  9. Dose refinement. ARAC's role

    SciTech Connect

    Ellis, J. S.; Sullivan, T. J.; Baskett, R. L.

    1998-06-01

    The Atmospheric Release Advisory Capability (ARAC), located at the Lawrence Livermore National Laboratory, since the late 1970's has been involved in assessing consequences from nuclear and other hazardous material releases into the atmosphere. ARAC's primary role has been emergency response. However, after the emergency phase, there is still a significant role for dispersion modeling. This work usually involves refining the source term and, hence, the dose to the populations affected as additional information becomes available in the form of source term estimates release rates, mix of material, and release geometry and any measurements from passage of the plume and deposition on the ground. Many of the ARAC responses have been documented elsewhere. 1 Some of the more notable radiological releases that ARAC has participated in the post-emergency phase have been the 1979 Three Mile Island nuclear power plant (NPP) accident outside Harrisburg, PA, the 1986 Chernobyl NPP accident in the Ukraine, and the 1996 Japan Tokai nuclear processing plant explosion. ARAC has also done post-emergency phase analyses for the 1978 Russian satellite COSMOS 954 reentry and subsequent partial burn up of its on board nuclear reactor depositing radioactive materials on the ground in Canada, the 1986 uranium hexafluoride spill in Gore, OK, the 1993 Russian Tomsk-7 nuclear waste tank explosion, and lesser releases of mostly tritium. In addition, ARAC has performed a key role in the contingency planning for possible accidental releases during the launch of spacecraft with radioisotope thermoelectric generators (RTGs) on board (i.e. Galileo, Ulysses, Mars-Pathfinder, and Cassini), and routinely exercises with the Federal Radiological Monitoring and Assessment Center (FRMAC) in preparation for offsite consequences of radiological releases from NPPs and nuclear weapon accidents or incidents. Several accident post-emergency phase assessments are discussed in this paper in order to illustrate

  10. Role of the pharmacist.

    PubMed

    Bottorff, Michael

    2006-12-01

    The prevalence of cardiovascular risk factors continues to rise, with considerable emphasis on the upward trends in obesity and diabetes mellitus, which have increased by 46% and 60%, respectively, in the past 10 years. The alarming increase in the prevalence of diabetes and obesity has resulted in the development of new and innovative drug therapies to assist in managing cardiometabolic risk factors. This advent creates many opportunities for pharmacists to evaluate patients' drug regimens and influence lifestyle modification. Drug therapy management programs allow pharmacists to take active roles in assessing drug regimens and to intervene as appropriate. No matter what their practice environment, pharmacists have numerous opportunities to recognize and recommend treatment for cardiometabolic risk factors and to increase patient compliance by educating patients and health care practitioners. PMID:17125450

  11. Nursing's role in nutrition.

    PubMed

    Henning, Michael

    2009-01-01

    There are not enough dietitians and nutritionists available to serve the entire healthcare industry. That means that nurses often fill the role of nutrition counselors. Nurses do not receive extensive education about nutrition, but there are great opportunities for nurses in nutrition, both as educators and researchers. One way this can happen is through the use of nutrition assessment tools. This article introduces a freeware nutritional assessment tool for use on Windows-based computers (available at http://nursing.jmu.edu). Unlike currently available tools, the Nutrition Analyzer is a stand-alone, Web-independent product, which builds a database of client data that can be manipulated for analysis and research. PMID:19726924

  12. Functional roles of fructose.

    PubMed

    Kim, Jinyoung; Song, Gwonhwa; Wu, Guoyao; Bazer, Fuller W

    2012-06-19

    During the periimplantation period of pregnancy, pig blastocysts undergo morphological changes and differentiation requiring secretion and transport of nutrients (histotroph) into the uterine lumen. Of these nutrients, glucose is converted to fructose, an isomer of glucose, by conceptus trophectoderm. Although glucose is an energy source for proliferation and growth of mammalian cells, the role of fructose in uterine histotroph is unclear although it is the most abundant hexose sugar in fetal blood and fluids of ungulate mammals (e.g., cows, sheep, and pigs). In this study, we used porcine trophectoderm cells to determine that fructose increased cell proliferation, as did glucose. Western blot analyses of porcine trophectoderm cell extracts revealed that fructose increased the abundance of phosphorylated-RPS6K, -EIF4EBP1, and -RPS6 over basal levels within 30 min, and those levels remained elevated to 120 min. Phosphorylation of both RPS6K and EIF4EBP1 proteins in response to fructose was inhibited by inhibitors of both PI3K and MTOR. Further, when we investigated the inhibition of glutamine-fructose-6-phosphate transaminase 1 (GFPT1) by azaserine (an inhibitor of GFPT1) and GFPT1 siRNA, we found that MTOR-RPS6K and MTOR-EIF4EBP1 signaling in response to fructose is mediated via GFPT1 activation and the hexosamine pathway. We further demonstrated that fructose stimulates the production of hyaluronic acid via GFPT1 and the hexosamine biosynthesis pathway. Collectively, these results demonstrate critical roles for fructose that are mediated via the hexosamine biosynthesis pathway to stimulate MTOR cell signaling, proliferation of porcine trophectoderm cells, and synthesis of hyaluronic acid, a significant glycosaminoglycan in the pregnant uterus. PMID:22623530

  13. [Asbestosis and microfiber role].

    PubMed

    Piolatto, P G; Pira, E; Putzu, M G; Massiccio, M; Romano, C

    2006-01-01

    Based on the predominant content of thin and short asbestos fibres in lung and mesothelioma tissues, it was recently stated (2005) that such fibres "appear to contribute to the causation of human malignant mesothelioma". In another study of the same year it was stated that fibres in the order of few microm length and 0.2 microm diameter are the sole able to induce mesothelioma. This scientific conclusions entail some implications from practical point of view. The enormous amount of information gained on asbestos in the last decades is based on the definition of a fibre as an alongated particle with an aspect-ratio of at least 3:1, a diameter < or = 3 microm and a length > or = 5 microm. These parameters were used up today to define occupational and in some case non-occupational limits. In which way can "reference" values be established if all lengths or only fibres shorter than 5 microm are considered? Nowadays we have no answer. Secondly, assuming a prevalent role of such fibres especially in mesothelioma cases, how can reliable estimates of past exposure obtained in a medico-legal context, since they have never been counted? Morever, how might he the employer responsibility assessed since short fibres were not measured by definition pathogenic, and this not measured, nor were there appropriate filtering systems up to the middle of the '80? PMID:17144416

  14. Climate's Role in Terroir

    NASA Astrophysics Data System (ADS)

    Jones, G. V.

    2012-12-01

    The marriage between a given winegrape cultivar planted in its ideal climate, over favorable topography and physical soil characteristics, combine to create the potential to produce fine wine. The French term terroir embodies this potential as a holistic concept that relates to both environmental and cultural factors that together influence the grape growing to wine production continuum. While the landscape, geology, soil, and climate strongly interact to influence the vine's balance of nutrients and water, climate is clearly of prevailing importance in that it limits where grapes can be grown at both the global and site scale. This talk will review the nature of climate's role in terroir through a discussion of the structure of climate in wine regions globally and how this structure influences cultivar suitability. Furthermore, the talk will use two of the most commonly planted red wine cultivars as examples - Pinot Noir and Cabernet Sauvignon - providing details on the historic, current, and future climate structure of wine regions growing these cultivars. In general the examination reveals that cool climate cultivars tend to have a narrower climate niche for high quality wine production, than do warmer climate cultivars, with less range of adaptation. Furthermore, the range of the climate suitability of these two cultivars shows that potentially new terroirs for each are waiting to be found.

  15. Enseigner quel francais du tourisme (Which French to Teach for Tourism).

    ERIC Educational Resources Information Center

    Larsson, Bjorn

    1992-01-01

    Development of a course in French for tourism and the hotel industry in Sweden is chronicled, focusing on the process of functional analysis used to determine appropriate language content. A general functional outline of touristic French and an outline of language functions specific to a restaurant situation are presented. (MSE)

  16. Pourquoi le francais et quel francais au Maroc? (Why French and Which French in Morocco?)

    ERIC Educational Resources Information Center

    Akouaou, Ahmed

    1984-01-01

    The status of French in Morocco is ambiguous: it is neither an official language nor a foreign language, and it would benefit greatly from an official definition that would allow a variety of language conflicts to be resolved. (MSE)

  17. Models and role models.

    PubMed

    ten Cate, Jacob M

    2015-01-01

    Developing experimental models to understand dental caries has been the theme in our research group. Our first, the pH-cycling model, was developed to investigate the chemical reactions in enamel or dentine, which lead to dental caries. It aimed to leverage our understanding of the fluoride mode of action and was also utilized for the formulation of oral care products. In addition, we made use of intra-oral (in situ) models to study other features of the oral environment that drive the de/remineralization balance in individual patients. This model addressed basic questions, such as how enamel and dentine are affected by challenges in the oral cavity, as well as practical issues related to fluoride toothpaste efficacy. The observation that perhaps fluoride is not sufficiently potent to reduce dental caries in the present-day society triggered us to expand our knowledge in the bacterial aetiology of dental caries. For this we developed the Amsterdam Active Attachment biofilm model. Different from studies on planktonic ('single') bacteria, this biofilm model captures bacteria in a habitat similar to dental plaque. With data from the combination of these models, it should be possible to study separate processes which together may lead to dental caries. Also products and novel agents could be evaluated that interfere with either of the processes. Having these separate models in place, a suggestion is made to design computer models to encompass the available information. Models but also role models are of the utmost importance in bringing and guiding research and researchers. PMID:25871413

  18. Sex Role Attitudes and Sex Role Stereotyping: Recent Literature.

    ERIC Educational Resources Information Center

    New Jersey Research Bulletin, 1996

    1996-01-01

    This annotated bibliography profiles 17 publications examining sex role attitudes/sex role stereotyping from the perspectives of ethnicity, gender, and age. Cited in the section on ethnicity are studies of work satisfaction/family functioning among working-class Mexican-American women and cultural variations in sex typing by students in the United…

  19. Role Engagement and Anonymity in Synchronous Online Role Play

    ERIC Educational Resources Information Center

    Cornelius, Sarah; Gordon, Carole; Harris, Margaret

    2011-01-01

    Role play activities provide opportunities for learners to adopt unfamiliar roles, engage in interactions with others, and get involved in realistic tasks. They are often recommended to foster the development of soft skills and a wider perspective of the world. Such activities are widely used as an online teaching approach, with examples ranging…

  20. Balancing Caregiving and Work: Role Conflict and Role Strain Dynamics

    ERIC Educational Resources Information Center

    Gordon, Judith R.; Pruchno, Rachel A.; Wilson-Genderson, Maureen; Murphy, Wendy Marcinkus; Rose, Miriam

    2012-01-01

    Positing role conflict as a bidirectional construct in which work interferes with caregiving (WIC) and caregiving interferes with work (CIW), this study investigated its antecedents (demands and support of caregiving and work) and consequences (role strain). A national sample of 583 women between the ages of 50 and 64 years identified using…

  1. Ten Roles for Teacher Leaders

    ERIC Educational Resources Information Center

    Harrison, Cindy; Killion, Joellen

    2007-01-01

    Teacher leaders assume a wide range of roles to support school and student success. Harrison and Killion describe 10 roles that teacher leaders can fulfill in their schools. As resource providers, they provide materials to help their colleagues. Instructional specialists help colleagues with instructional strategies, and curriculum specialists…

  2. FORCES INFLUENCING THE COUNSELOR'S ROLE.

    ERIC Educational Resources Information Center

    MOLER, DONALD

    DEFINING THE ROLE OF A COUNSELOR IS A TASK WHICH IS COMPLICATED BY THE CHANGING WORLD, THE CHANGING SOCIAL STRUCTURE, AND THE INFLUENCES OF GOVERNMENT. THE ROLE IS FURTHER COMPLICATED BY THE FACT THAT COUNSELING HAS ORIGINATED FROM A VARIETY OF DISCIPLINES, BORROWING FROM THE JOB OF THE TEACHER, THE ADMINISTRATOR, THE SOCIAL WORKER, AND THE…

  3. Changing Societal Roles and Teaching.

    ERIC Educational Resources Information Center

    Dow, Ruth McNabb

    This handbook for home economics teachers as well as those teaching social studies and consumer education is designed to provide content and numerous student activities that explore the nature and effects of changing roles in society, particularly sex-related roles. The handbook begins with a brief section containing ten short single paragraph…

  4. Sex Role and Depressive Mood.

    ERIC Educational Resources Information Center

    Small, Arnold; And Others

    Research has suggested that an association exists between sex role identity and typing and affective states. The relationship of sex role type and depressive mood was explored through the direct manipulation of affect in a mood induction procedure. Female (N=208) and male (N=131) subjects, classified as either androgynous, masculine, feminine, or…

  5. ROLE CONFLICTS OF SCHOOL PRINCIPALS.

    ERIC Educational Resources Information Center

    GROSS, NEAL; AND OTHERS

    THE PURPOSE OF THIS STUDY WAS TO ISOLATE THE ROLE CONFLICTS TO WHICH SCHOOL PRINCIPALS ARE EXPOSED, THE METHODS USED TO RESOLVE THEM, AND THE FREQUENCY WITH WHICH THEY OCCUR. THE SOCIAL MATRIX OF ROLE CONFLICT IS BASED ON DIFFERING EXPECTATIONS OF COGNITIVE BEHAVIOR INTERPRETATIONS. THUS, WHEN PARENTS, STUDENTS, TEACHERS, OTHER ADMINISTRATORS, AND…

  6. Union Roles in Workplace Literacy.

    ERIC Educational Resources Information Center

    Hensley, Stephen Michael

    1993-01-01

    Discusses roles for labor unions in resolving workforce deficiencies, suggesting that labor, management, and government must work together to develop cooperative training initiatives. Describes labor's historic role in basic and workplace literacy training, lists skills workers need in the "new" workplace, describes exemplary union-management…

  7. Understanding medical practice team roles.

    PubMed

    Hills, Laura

    2015-01-01

    Do you believe that the roles your employees play on your medical practice team are identical to their job titles or job descriptions? Do you believe that team roles are determined by personality type? This article suggests that a more effective way to build and manage your medical practice team is to define team roles through employee behaviors. It provides 10 rules of behavioral team roles that can help practice managers to select and build high-performing teams, build more productive team relationships, improve the employee recruitment process, build greater team trust and understanding; and increase their own effectiveness. This article describes in detail Belbin's highly regarded and widely used team role theory and summarizes four additional behavioral team role theories and systems. It offers lessons learned when applying team role theory to practice. Finally, this article offers an easy-to-implement method for assessing current team roles. It provides a simple four-question checklist that will help practice managers balance an imbalanced medical practice team. PMID:26062328

  8. Classroom Roles and School Adjustment

    ERIC Educational Resources Information Center

    Van Rossem, Ronan; Vermande, Marjolijn M.

    2004-01-01

    The peer group is an important developmental context for children. In this paper we present a method to operationalize a child's integration into the classroom by their informal social classroom roles, which we obtained using a blockmodel analysis based on role equivalence. This method differs in several respects from the common socio-metric…

  9. Current Research on Sex Roles.

    ERIC Educational Resources Information Center

    Sells, Lucy W., Comp.

    Focusing on women, this annotated bibliography reviews recent research-oriented literature that investigates sex roles. The main concern is the role and place of women in present-day United States society. The literature areas which the bibliography covers are bibliographies and sources, action organizations, media, women's movement, affirmative…

  10. Role Clarity and Organizational Level.

    ERIC Educational Resources Information Center

    Posner, Barry Z.; Butterfield, D. Anthony

    1978-01-01

    Role clarity was examined in terms of its relationship with personal outcomes and organizational effectiveness. Organizational level as moderator of such relationship was also investigated. Hypotheses based on prior research were confirmed. Role clarity was positively related to perceptions of job satisfaction, personal influence, organizational…

  11. Role of Atmospheric Transport on the Arctic Amplification: Adjusting Role

    NASA Astrophysics Data System (ADS)

    KUG, J.; Yim, B.; Jin, F.

    2013-12-01

    It is controversial whether the atmospheric transport plays a role in arctic amplification. Recently, Hwang et al. (2011) showed that the magnitude of the arctic amplification is negatively correlated with anomalous poleward atmospheric transport. That is, when the arctic amplification is strong (weak), the atmospheric transport plays a negative (positive) role in the arctic amplification. In this study, it is discussed what is a physical mechanism to determine the role of atmospheric transport and relation with the arctic amplification. Here, we suggest adjusting roles of atmospheric transport. The strength of local feedback over the Arctic determines zonal wind changes. The zonal wind changes are determined by two factors. The first one is polar cap cooling, and second is surface warming. They play opposite roles. So, there will be two different zonal wind responses in high-latitude to the greenhouse warming. Depending on the zonal wind response, the atmospheric transport can play a different role because the zonal wind changes can organize synoptic eddy feedbacks including heat flux, which largely contributes to poleward energy transport. We show here that when polar cap cooling is strong, and surface warming over Arctic is relatively weak, the Jet stream tends to be shifted poleward, so it leads to poleward atmospheric transport. On the other hand, when the surface warming is too strong, it lead to southward shift of Jet stream and equatorward atmospheric transport, which paly a negative role in the Arctic amplification.

  12. The Nephrology Clinical Research Nurse Role: Potential Role Conflicts.

    PubMed

    Micklos, Lisa

    2016-01-01

    Clinical research nursing is becoming more visible to nephrology professionals. As more nephrology practices and units are participating in clinical trials, clinical research nursing is gaining interest as a career niche among nephrology nurses. This unique specialty requires that nephrology clinical nurse nurses (CRNs) reconcile the roles of nurse as caregiver and nurse as researcher, which may result in a role conflict. Nephrology nurses should be aware that they may experience this role conflict when transitioning from patient care to a position as a clinical research nurse. These nurses can rely on the American Nurses Association's Code of Ethics for Nurses and the Oncology Nursing Society's Oncology Clinical Trials Nurse Competencies to help reconcile the potential role conflict. PMID:27501633

  13. Roles of galectins in infection

    PubMed Central

    Vasta, Gerardo R.

    2013-01-01

    Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous (‘self) carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and effector factors in innate immunity. Some parasites subvert the recognition roles of the vector or host galectins to ensure successful attachment or invasion. This Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses. PMID:19444247

  14. Occupational Roles in Children's Literature

    ERIC Educational Resources Information Center

    Hillman, Judith Stevinson

    1976-01-01

    Compares children's literature of the 1930s and that of recent times in terms of occupational roles and sex typing. Little change was found in number or type of women's occupations despite the recent political, social and economic changes. (MS)

  15. The Changing Role of Logarithms

    ERIC Educational Resources Information Center

    Thomas, F. H.

    1974-01-01

    With the advent of computers and electronic calculators, the role of logarithms in the curriculum is changing. An intuitive approach to logarithms, stressing the notion of isomorphism, is discussed. (SD)

  16. Role Models in Aquatic Occupations.

    ERIC Educational Resources Information Center

    Brown, Mabel C.

    1982-01-01

    Provided for each of 12 minority group role models in aquatic occupations are job responsibilities, educational requirements, comments on a typical day at the job, salary range, and recommendations for students wishing to enter the field described. (JN)

  17. The Arctic's Role in Climate.

    ERIC Educational Resources Information Center

    Baker, D. James

    1986-01-01

    Discusses the special role the Arctic region plays in climate, focusing on: (1) the global energy balance; (2) feedback mechanisms; (3) effects of increasing carbon dioxide; and (4) climate processes study programs. (JN)

  18. Technology's Role in NASA's Future

    NASA Video Gallery

    NASA Chief Technologist Bobby Braun talks to NASA managers about the vital role technology research and development will play in NASA's future. Braun discusses how NASA will use new technologies to...

  19. Roles for the Family Caregiver

    MedlinePlus

    ... Communicator The family caregiver has many roles besides giving the patient hands-on care. Most people think ... caregiver becomes an advocate for the patient by giving this information to the health care team. Although ...

  20. Transformative Learning in Managerial Role Transitions

    ERIC Educational Resources Information Center

    Isopahkala-Bouret, Ulpukka

    2008-01-01

    The purpose of this study is to investigate the nature of learning in work role transitions from specialist roles to managerial roles in a context of a large international technology organisation. Prior theorisation of learning in role transitions has been based on quantitative, psychologically-oriented studies prescribing different role and…

  1. Role Socialization of Juvenile Court Probation Officers.

    ERIC Educational Resources Information Center

    Petronio, Richard J.

    1982-01-01

    Tested the degree of association between probation officers' sent and received roles and role behavior in four juvenile courts. Found the role communicated to probation officers by their superiors was predictive of the role the probation officers perceived but not of the role as enacted with juveniles. (Author)

  2. Linking species functional roles to their network roles.

    PubMed

    Coux, Camille; Rader, Romina; Bartomeus, Ignasi; Tylianakis, Jason M

    2016-07-01

    Species roles in ecological networks combine to generate their architecture, which contributes to their stability. Species trait diversity also affects ecosystem functioning and resilience, yet it remains unknown whether species' contributions to functional diversity relate to their network roles. Here, we use 21 empirical pollen transport networks to characterise this relationship. We found that, apart from a few abundant species, pollinators with original traits either had few interaction partners or interacted most frequently with a subset of these partners. This suggests that narrowing of interactions to a subset of the plant community accompanies pollinator niche specialisation, congruent with our hypothesised trade-off between having unique traits vs. being able to interact with many mutualist partners. Conversely, these effects were not detected in plants, potentially because key aspects of their flowering traits are conserved at a family level. Relating functional and network roles can provide further insight into mechanisms underlying ecosystem functioning. PMID:27169359

  3. Bioenergetic roles of mitochondrial fusion.

    PubMed

    Silva Ramos, Eduardo; Larsson, Nils-Göran; Mourier, Arnaud

    2016-08-01

    Mitochondria are bioenergetic hotspots, producing the bulk of ATP by the oxidative phosphorylation process. Mitochondria are also structurally dynamic and undergo coordinated fusion and fission to maintain their function. Recent studies of the mitochondrial fusion machinery have provided new evidence in detailing their role in mitochondrial metabolism. Remarkably, mitofusin 2, in addition to its role in fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway. Here, we review the bioenergetic roles of mitochondrial dynamics and emphasize the importance of the in vitro growth conditions when evaluating mitochondrial respiration. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016,' edited by Prof. Paolo Bernardi. PMID:27060252

  4. Role of the school physician.

    PubMed

    Devore, Cynthia DiLaura; Wheeler, Lani S M

    2013-01-01

    The American Academy of Pediatrics recognizes the important role physicians play in promoting the optimal biopsychosocial well-being of children in the school setting. Although the concept of a school physician has existed for more than a century, uniformity among states and school districts regarding physicians in schools and the laws governing it are lacking. By understanding the roles and contributions physicians can make to schools, pediatricians can support and promote school physicians in their communities and improve health and safety for children. PMID:23277314

  5. Transitioning between Work and Family Roles as a Function of Boundary Flexibility and Role Salience

    ERIC Educational Resources Information Center

    Winkel, Doan E.; Clayton, Russell W.

    2010-01-01

    This study investigates the manner in which people separate their work and family roles and how they manage the boundaries of these two important roles. Specifically, we focus on how role flexibility and salience influence transitions between roles. Results indicate that the ability and willingness to flex a role boundary and role salience are…

  6. Gender Stereotypes and Social Roles.

    ERIC Educational Resources Information Center

    Eagly, Alice H.

    The reason that people think women and men differ in their general qualities may be that the two sexes tend to be observed in different social roles. To explore the sources of stereotypes about men and women several experiments were conducted. Most of the studies involved randomly selected college students who were presented with a description of…

  7. Role Modeling for Clinical Educators.

    ERIC Educational Resources Information Center

    Ettinger, Ellen Richter

    1991-01-01

    To become better role models, higher educators in institutions of clinical education should be conscious of the behaviors they demonstrate and the broad range of activities and attitudes that students observe and emulate, including clinical competence, professional demeanor, doctor-patient interactions, ethical values, and social consciousness.…

  8. The Faculty Role in Budgeting.

    ERIC Educational Resources Information Center

    Meisinger, Richard J., Jr.; Dubeck, Leroy W.

    1984-01-01

    Specific roles faculty members can play in their institution's budget processes are discussed, and the general ends served by budgets are identified. Each of the dimensions of institutional character (e.g., size, mission) determines the ways in which participants in budgeting will interact. For example, broader faculty participation in budgeting…

  9. Exploring Unique Roles for Psychologists

    ERIC Educational Resources Information Center

    Ahmed, Mohiuddin; Boisvert, Charles M.

    2005-01-01

    This paper presents comments on "Psychological Treatments" by D. H. Barlow. Barlow highlighted unique roles that psychologists can play in mental health service delivery by providing psychological treatments--treatments that psychologists would be uniquely qualified to design and deliver. In support of Barlow's position, the authors draw from…

  10. Domestic Role Sharing in Sweden.

    ERIC Educational Resources Information Center

    Haas, Linda

    1981-01-01

    Investigated the extent to which Swedish couples (N=128) share domestic tasks using a mail survey. Suggests Swedish couples shared household chores more evenly than American couples. Results indicated variables measuring social exchange theory, family life-cycle stage, and socialization had the greatest influence on role sharing behavior.…

  11. Psychology's Role in Health Care.

    ERIC Educational Resources Information Center

    American Psychological Association, Washington, DC.

    This information packet contains eight two- to three-page publications from the American Psychological Association series "Psychological Services for the 21st Century, Psychology's Role in Health Care: Studying Human Behavior; Promoting Health; Saving Health Care Dollars; Providing Mental Health Services." The focus of the series is the connection…

  12. Role models face class expulsion.

    PubMed

    Sprinks, Jennifer

    There are plans to drop Mary Seacole and Florence Nightingale from the curriculum taught in schools, according to leaked reports. Here, nurse leaders protest that this would rob young people of valuable role models and undermine the image of the profession. It is also suggested that a person's contribution to society is more important than their personality. PMID:23427681

  13. The role of induction therapy

    PubMed Central

    Moremen, Jacob R.; Skopelja, Elaine N.

    2014-01-01

    The incidence of esophageal cancer has been steadily increasing. The 5-year survival of esophageal cancer has minimally improved over the past 30 years. In this article, we review the management of esophageal cancer, focusing on the literature investigating the role of induction chemotherapy and radiation therapy. PMID:24876935

  14. ISO 9000: The Librarian's Role.

    ERIC Educational Resources Information Center

    Dobson, Chris; Ernst, Carolyn

    1999-01-01

    Describes the special library's role in implementing ISO 9000 (i.e., a series of international quality-assurance standards developed by the International Organization of Standards). Topics discussed include document and data control, keeping the standards current, documentation of procedures, the ISO 9000 audit, and benefits for the library. (MES)

  15. Persona; Social Role and Personality.

    ERIC Educational Resources Information Center

    Perlman, Helen Harris

    These essays examine ways in which people, during the major part of adulthood, know and experience their identity through the roles they assume in work, marriage, and parenthood. Referring to Freud's definition of maturity as the ability to love and to work, the author discusses such concerns as adulthood and personal change, common problems of…

  16. Childhood Obesity: The Caregiver's Role.

    ERIC Educational Resources Information Center

    Haschke, Bernadette

    2003-01-01

    Describes the role caregivers play in helping young children dealing with obesity. Examines: (1) causes of childhood obesity; (2) caregiver's position; (3) learning nutrition concepts; (4) preparing and serving healthy foods; (5) encouraging physical activity; (6) working with parents; and (7) assisting an obese child. (SD)

  17. Perceived roles of oncology nursing.

    PubMed

    Lemonde, Manon; Payman, Naghmeh

    2015-01-01

    The Canadian Association of Nurses in Oncology (CANO) Standards of Care (2001) provides a framework that delineates oncology nursing roles and responsibilities. The purpose of this study was to explore how oncology nurses perceive their roles and responsibilities compared to the CANO Standards of Care. Six focus groups were conducted and 21 registered nurses (RNs) from a community-based hospital participated in this study. Transcripts were analyzed using qualitative inductive content analysis. Three themes were identified: (1) Oncology nurses perceive a gap between their defined roles and the reality of daily practice, as cancer care becomes more complex and as they provide advanced oncology care to more patients while there is no parallel adaptation to the health care system to support them, such as safe staffing; (2) Oncology nursing, as a specialty, requires sustained professional development and leadership roles; and (3) Oncology nurses are committed to providing continuous care as a reference point in the health care team by fostering interdisciplinary collaboration andfacilitating patient's navigation through the system. Organizational support through commitment to appropriate staffing and matching scope ofpractice to patient needs may lead to maximize the health and well-being of nurses, quality of patient care and organizational performance. PMID:26897865

  18. The Economic Role of Women.

    ERIC Educational Resources Information Center

    Women's Bureau (DOL), Washington, DC.

    Statistical information pertaining to one of the most important changes in the American economy in this century--the increase in the number of women who work outside the home--is presented as an introduction to the broader range of topics which will be considered by the Advisory Committee on the Economic Role of Women. Job-related aspects of…

  19. Perceptions of the Volunteer Role.

    ERIC Educational Resources Information Center

    Lucas, Wayne L.

    1987-01-01

    Examined questionnaire responses from 51 probation and parole line officers to determine staff perceptions of one Volunteers in Corrections program. Findings suggest that officers view volunteer role as involving several functions, including research, treatment, counseling, supervision, volunteer program operations, clerical, and investigation.…

  20. Political Elections: The Library Role.

    ERIC Educational Resources Information Center

    Link, Terry

    1984-01-01

    Discusses library role in providing access to information on political candidates and issues. Press coverage, political party literature, Federal Election Commission, interest groups, monographs, serials, and online databases are highlighted. Lists of 15 references, 89 national organizations that rate members of Congress, and 9 active political…

  1. The Role of International Expert

    ERIC Educational Resources Information Center

    Penn, Helen

    2008-01-01

    This article reviews Sally Lubeck's international contributions. It describes her role as "rapporteur" for the OECD review of early education and care services in the UK, one of 20 such reviews commissioned by the OECD. It discusses the continued relevance of her observations and comments on provision in the UK. The article goes on to comment…

  2. Sex Roles: Symposium V B.

    ERIC Educational Resources Information Center

    Lua, Sokhong; And Others

    Reported is an exploratory investigation of attitudes toward child-rearing practices in Malaysia, including an attempt to investigate and analyze the nature and extent of involvement of Malaysian fathers in child care. There is also an abstract of a study of the influence of child-rearing practices on marital role expectations in Bengali,…

  3. CTE's Role in Worker Retraining

    ERIC Educational Resources Information Center

    Hyslop, Alisha

    2011-01-01

    The economic downturn and growing skills mismatch dramatically highlight the importance of programs that retrain workers for the demands of the current workplace. The career and technical education (CTE) system has played a large role in the development of these programs, and CTE educators are leading efforts to ensure that new and newly…

  4. The Effect of Role Ambiguity and Role Conflict on Performance of Vice Principals: The Mediating Role of Burnout

    ERIC Educational Resources Information Center

    Celik, Kazim

    2013-01-01

    Problem Statement: Role ambiguity and role conflict are considered issues that affect performance and lead to burnout. While numerous studies have analyzed role ambiguity or role conflict in relation to burnout or performance, few studies have studied all of these issues together. Since vice principals are expected to carry out a variety of…

  5. Occupational Role Identity of Women Academic Librarians.

    ERIC Educational Resources Information Center

    Cravey, Pamela J.

    1991-01-01

    A national survey which examined the occupational role identity of female academic librarians collected personal, demographic, and job data. In addition, a test for orientation to the occupational role and a sex-role orientation test were administered. Women academic librarians were found to hold a positive and unique occupational role identity.…

  6. Principals Discuss Their Roles: An Observational Study.

    ERIC Educational Resources Information Center

    Rogers, Kathryn S.

    What principals are taught about their roles differs markedly from how they actually perceive and experience their roles. To discover the principals' views, comments made in discussion groups by 44 principals in a large urban Midwest school system over a four-month period were analyzed. Their descriptions of their roles and desired role changes…

  7. Role of MYC in Medulloblastoma

    PubMed Central

    Roussel, Martine F.; Robinson, Giles W.

    2013-01-01

    Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosis (Roussel et al. 1979) and its cloning (Vennstrom et al. 1982), c-MYC (MYC), as well as its paralogs MYCN and MYCL1, has been shown to play essential roles in cycling progenitor cells born from proliferating zones during embryonic development, and in all proliferating cells after birth. MYC deletion induces cell-cycle exit or cell death, depending on the cell type and milieu, whereas MYC and MYCN amplification or overexpression promotes cell proliferation and occurs in many cancers. Here, we review the relationship of MYC family proteins to the four molecularly distinct medulloblastoma subgroups, discuss the possible roles MYC plays in each of these subgroups and in the developing cells of the posterior fossa, and speculate on possible therapeutic strategies targeting MYC. PMID:24186490

  8. Role of Calpain in Apoptosis

    PubMed Central

    Momeni, Hamid Reza

    2011-01-01

    Apoptosis, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. While the importance of caspases in apoptosis is established, several noncaspase proteases (Ca2+-dependent proteases) such as calpain may play a role in the execution of apoptosis. The calpain family consists of two major isoforms, calpain I and calpain II which require µM and mM Ca2+ concentrations to initiate their activity. An increase in intracellular Ca2+ level is thought to trigger a cascade of biochemical processes including calpain activation. Once activated, calpains degrade membrane, cytoplasmic and nuclear substrates, leading to the breakdown of cellular architecture and finally apoptosis. The activation of calpain has been implicated in neuronal apoptosis following spinal cord injuries and neurodegenerative diseases. This review focuses on calpain with an emphasis on its key role in the proteolysis of cellular protein substrates following apoptosis. PMID:23507938

  9. Role ambiguity, employee gender, and workplace friendship.

    PubMed

    Chen, Chien-Yu; Mao, Hsiao-Yen; Hsieh, An-Tien

    2012-06-01

    The importance of workplace friendship is recognized by researchers and practitioners, but its antecedents with respect to work roles are not well understood. Employees' gender might moderate a relationship between work roles and friendships. Data from a survey of 221 international tourist hotel employees showed that a key aspect of job support, role ambiguity, was negatively related to having workplace friendships. However, employees' gender did not moderate this relationship. Role clarity (the opposite of role ambiguity) may facilitate workplace friendships. PMID:22897079

  10. Mitigating earthquakes; the federal role

    USGS Publications Warehouse

    Press, F.

    1977-01-01

    With rapid approach of a capability to make reliable earthquake forecasts, it essential that the Federal Government play a strong, positive role in formulating and implementing plans to reduce earthquake hazards. Many steps are being taken in this direction, with the President looking to the Office of Science and Technology Policy (OSTP) in his Executive Office to provide leadership in establishing and coordinating Federal activities. 

  11. Sex role ideology among physicians.

    PubMed Central

    Leichner, P.; Harper, D.

    1982-01-01

    Physicians have been accused by some feminist writers of having traditional views on sex roles that make them part of society's oppressive power structure and therefore responsible in part for the high incidence of psychologic problems and drug dependency among women. To assess whether physicians' attitudes towards women are indeed polarized in a traditional fashion, a sex role ideology questionnaire was given to all practising physicians belonging to the Manitoba Medical Association. Overall the physicians were found to be more feminist than male college students and a group of women with traditional beliefs. Psychiatrists, who had the highest adjusted group mean score on a sex role ideology scale (high indicating feminist beliefs), were found to be significantly more feminist than family practitioners, surgeons, and obstetricians and gynecologists, although not more so than internists, radiologists, pediatricians and anesthesiologists. These findings do not support the assumption that physicians have traditional views that reflect those of society. However, the significant differences between specialties emphasize the need for educating physicians and medical students in the behaviour of women. PMID:7104916

  12. The Relationship of Women's Role Strain to Social Support, Role Satisfaction, and Self Efficacy.

    ERIC Educational Resources Information Center

    Erdwins, Carol J.; Buffardi, Louis C.; Casper, Wendy J.; O'Brien, Alison

    2001-01-01

    Relationship of social support, role satisfaction, and self-efficacy to measures of role strain was explored in married, employed women with preschool aged children. Self efficacy in work and parental role proved to be a significant predictor of work-family conflict and role overload. Organizational support on role conflict was mediated by job…

  13. [The biological role of sulfatides].

    PubMed

    Suchański, Jarosław; Ugorski, Maciej

    2016-01-01

    Sulfatides (3-O-sulfogalactosylceramides, sulfated galactocerebrosides, SM4) are esters of sulfuric acid with galactosylceramides. These acidic glycosphingolipids, present at the external leaflet of the plasma membrane, are synthesized by a variety of mammalian cells. They are especially abundant in the myelin sheath of oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Studies using cerebroside galactosyltransferase-deficient mice revealed that sulfatides are responsible for proper structure and functioning of myelin. Large amounts of sulfatides are also found in the kidney, gastrointestinal tract, islets of Langerhans, and membranes of erythrocytes, thrombocytes and granulocytes. They are ligands for numerous proteins, but in most cases the biological role of such interactions is poorly understood. A notable exception is their binding by P- and L-selectins. Platelet sulfatides are major ligands for P-selectin, and this interaction is critical for the formation of stable platelet aggregates. Sulfatides also bind to chemokines, and seem to play a role in regulation of cytokine expression in human lymphocytes and monocytes. Aberrant metabolism of sulfatides, could cause several important human diseases. In this article, we describe the changes in sulfatide expression associated with such nervous disorders as metachromatic leukodystrophy (MLD), Parkinson's disease and Alzheimer's disease, and several types of cancer, e.g. colon cancer, kidney cancer, and ovarian cancer. We also discuss the involvement of sulfatides in cancer progression, diabetes and autoimmune and immune disorders such as multiple sclerosis. This acidic glycosphingolipids seem to play an important role in pathogenesis of infectious diseases, serving as receptors for binding various bacteria and viruses. PMID:27180966

  14. About Sleep's Role in Memory

    PubMed Central

    2013-01-01

    Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of “sleep and memory” research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems. PMID:23589831

  15. Refinement of boards' role required.

    PubMed

    Umbdenstock, R J

    1987-01-01

    The governing board's role in health care is not changing, but new competitive forces necessitate a refinement of the board's approach to fulfilling its role. In a free-standing, community, not-for-profit hospital, the board functions as though it were the "owner." Although it does not truly own the facility in the legal sense, the board does have legal, fiduciary, and financial responsibilities conferred on it by the state. In a religious-sponsored facility, the board fulfills these same obligations on behalf of the sponsoring institute, subject to the institute's reserved powers. In multi-institutional systems, the hospital board's power and authority depend on the role granted it by the system. Boards in all types of facilities are currently faced with the following challenges: Fulfilling their basic responsibilities, such as legal requirements, financial duties, and obligations for the quality of care. Encouraging management and the board itself to "think strategically" in attacking new competitive market forces while protecting the organization's traditional mission and values. Assessing recommended strategies in light of consequences if constituencies think the organization is abandoning its commitments. Boards can take several steps to match their mode of operation with the challenges of the new environment. Boards must rededicate themselves to the hospital's mission. Trustees must expand their understanding of health care trends and issues and their effect on the organization. Boards must evaluate and help strengthen management's performance, rather than acting as a "watchdog" in an adversarial position. Boards must think strategically, rather than focusing solely on operational details. Boards must evaluate the methods they use for conducting business. PMID:10280356

  16. The role of the university.

    PubMed Central

    Starck, P L

    1987-01-01

    The role of the university, and particularly the health sciences university, in promoting positive health for women is twofold. First, the dissemination of existing knowledge raises awareness of special health needs and identifies gaps in the present research and literature base. Second, universities must project future needs of women in a rapidly changing society where such things as space travel may become commonplace. Reduction of the risk of debilitating disease and promotion of positive attitudes will enhance the quality of life for women. A logotherapeutic approach to choosing one's own attitudes toward life's challenges promotes successful coping in a dynamic society. PMID:3120225

  17. Bronchovascular role in pulmonary congestion.

    PubMed

    McIlveen, S A

    2000-12-01

    1. A postulated role for the bronchial circulation in the development of pulmonary congestion may be based on recent studies of bronchovascular control. 2. The bronchial circulation is the nutrient blood supply of the conducting airways and, therefore, plays an important role in the function of the bronchial mucosa. Mucosal swelling secondary to elevation of mucosal capillary hydrostatic pressure may decrease airway calibre, increase resistance to airflow and precipitate symptoms of pulmonary congestion. 3. Resting mucosal capillary hydrostatic pressure is relatively constant due to autoregulation of bronchial blood flow and is maintained low by nett bronchovascular constriction due to the dominance of autonomic vasoconstriction over nitric oxidedependent vasodilatation. 4. Bronchial blood flow is also regulated by cardiac afferent reflexes. Stimulation of cardiac vagal and spinal afferents produces vasodilatation and vasoconstriction, respectively. Tonic activity of cardiac spinal afferents probably contributes to the resting autonomic vasoconstriction. 5. Therefore, mild heart failure, which is associated with abnormal cardiovascular reflex function, may decrease cardiac spinal afferent-mediated bronchial vasoconstriction and produce active dilatation due to stimulation of cardiac vagal afferents by excessive myocardial stretch, leading to bronchial mucosal swelling and pulmonary congestion. PMID:11117228

  18. Role of Microglia in Neurotrauma

    PubMed Central

    Loane, David J.; Byrnes, Kimberly R.

    2010-01-01

    Microglia are the primary mediators of the central nervous system's (CNS) immune defense system and are integral to the subsequent inflammatory response. The role of microglia in the injured CNS is under scrutiny as research has begun to fully explore how post-injury inflammation contributes to secondary damage and recovery of function. Whether microglia are ‘good’ or ‘bad’ is under debate, with strong support for a dual role or differential activation of microglia. Microglia release a number of factors that modulate secondary injury and recovery after injury, including pro- and anti-inflammatory cytokines, chemokines, nitric oxide, prostaglandins, growth factors and superoxide species. Here we review experimental work on the complex and varied responses of microglia in terms of both detrimental and beneficial effects. In addition, the impact of microglial activation in two examples of CNS injury - spinal cord and traumatic brain injury - will be discussed. Microglial activation is integral to the response of CNS tissue to injury. As such, future research should now focus on clarifying the signals and mechanisms by which microglia can be guided to promote optimal functional recovery. PMID:20880501

  19. Role models for complex networks

    NASA Astrophysics Data System (ADS)

    Reichardt, J.; White, D. R.

    2007-11-01

    We present a framework for automatically decomposing (“block-modeling”) the functional classes of agents within a complex network. These classes are represented by the nodes of an image graph (“block model”) depicting the main patterns of connectivity and thus functional roles in the network. Using a first principles approach, we derive a measure for the fit of a network to any given image graph allowing objective hypothesis testing. From the properties of an optimal fit, we derive how to find the best fitting image graph directly from the network and present a criterion to avoid overfitting. The method can handle both two-mode and one-mode data, directed and undirected as well as weighted networks and allows for different types of links to be dealt with simultaneously. It is non-parametric and computationally efficient. The concepts of structural equivalence and modularity are found as special cases of our approach. We apply our method to the world trade network and analyze the roles individual countries play in the global economy.

  20. Utilizing Peer Mentor Roles in Learning Communities

    ERIC Educational Resources Information Center

    Rieske, Laura Jo; Benjamin, Mimi

    2015-01-01

    For a number of learning community programs, peer mentors provide an additional layer of staffing support. This chapter highlights peer mentor roles from a sample of programs and suggests important components for the construction of these roles.

  1. Family size and sex-role stereotypes.

    PubMed

    Clarkson, F E; Vogel, S R; Broverman, I K; Broverman, D M; Rosenkrantz, P S

    1970-01-23

    Social attitudes about sex roles have been implicated as important factors in population growth. Degree of incorporation of stereotypic sex roles into the self-concepts of mothers is found to be related to completed family size. PMID:5409743

  2. Wanted: Active Role Models for Today's Kids

    MedlinePlus

    ... this page please turn Javascript on. Feature: Reducing Childhood Obesity Wanted: Active Role Models for Today's Kids Past ... the active role models they can get. "With childhood obesity at an all-time high, we need to ...

  3. Role of atomic collisions in fusion

    SciTech Connect

    Post, D.E.

    1982-04-01

    Atomic physics issues have played a large role in controlled fusion research. A general discussion of the present role of atomic processes in both magnetic and inertial controlled fusion work is presented.

  4. Role of Akirin in Skeletal Myogenesis

    PubMed Central

    Chen, Xiaoling; Huang, Zhiqing; Wang, Huan; Jia, Gang; Liu, Guangmang; Guo, Xiulan; Tang, Renyong; Long, Dingbiao

    2013-01-01

    Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin and discuss recent advances in our understanding of its role and signal pathway in skeletal myogenesis. PMID:23396110

  5. Perspectives on role socialization of nurses.

    PubMed

    Christman, L

    1991-01-01

    Individuals enact roles according to their personal knowledge of the role and the expectations of others interacting with the role. This is especially evident in patient care, where depths of knowledge are crucial to outcomes. The pecking order of health care professionals is directly related to the knowledge levels of the role enactors. Nurses tend to be the proverbial low man on the totem pole. PMID:1896312

  6. Role of akirin in skeletal myogenesis.

    PubMed

    Chen, Xiaoling; Huang, Zhiqing; Wang, Huan; Jia, Gang; Liu, Guangmang; Guo, Xiulan; Tang, Renyong; Long, Dingbiao

    2013-01-01

    Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin and discuss recent advances in our understanding of its role and signal pathway in skeletal myogenesis. PMID:23396110

  7. Restaurant Role-Play in Psychology

    ERIC Educational Resources Information Center

    Borya, Anthony

    2013-01-01

    Research methods is perceived as a technical and difficult topic by some students. Using role-play to teach it can make it more accessible, meaningful and engaging. Role-playing the familiar roles of customer and waiting staff at a restaurant and discussing the variables that may affect the size of tips can help students to learn some of the key…

  8. The Role of Libraries in Economic Restructuring.

    ERIC Educational Resources Information Center

    Fine, Sara

    1990-01-01

    Discusses the roles academic and public libraries can play in the process of economic restructuring and development. A business school library in Hungary is described, and its role in economic restructuring and the education of future managers is discussed; and the role of public libraries in the United States is examined. (four references) (LRW)

  9. Nature or Nurture? Gender Roles Scavenger Hunt

    ERIC Educational Resources Information Center

    Whalen, Shannon; Maurer-Starks, Suanne

    2008-01-01

    The examination of gender roles and stereotypes and their subsequent impact on sexual behavior is a concept for discussion in many sex education courses in college and sex education units in high school. This analysis often leads to a discussion of the impact of nature vs. nurture on gender roles. The gender roles scavenger hunt is an interactive…

  10. Gender Role Socialization in Jewish Men.

    ERIC Educational Resources Information Center

    Lasser, Jon; Gottlieb, Michael C.

    There has been little empirical research on the gender role socialization of Jewish men. This paper explores Jewish male gender role socialization and provides a model by which gender and ethnicity may be studied. A description of the gender role socialization of Jewish men, with an emphasis on advantages and disadvantages of such socialization…

  11. ROLE EXPECTATIONS AND PERCEPTIONS OF SCHOOL PRINCIPALS.

    ERIC Educational Resources Information Center

    SWEITZER, ROBERT E.; AND OTHERS

    EFFORTS WERE MADE TO DISCOVER THE RELATIONSHIPS BETWEEN SUPERINTENDENTS, PRINCIPALS, AND TEACHERS. MAJOR AREAS OF INVESTIGATION CONCERNED THE ROLE OF THE PRINCIPAL AND HIS FULFILLMENT OF THAT ROLE. THE STUDY WAS TO PROVIDE A BASIS FOR FURTHER RESEARCH IN THESE AREAS. THE ROLE OF THE PRINCIPAL CONCERNED THE TASKS OF SELECTION OF CURRICULUM,…

  12. Sex Roles and Fertility in College Women.

    ERIC Educational Resources Information Center

    Falbo, Toni; And Others

    1978-01-01

    The relationship of sex role acceptance to actual and desired fertility was assessed in a sample of female college students and women's organization members. Multiple regression analysis indicated that behavioral measures of sex role acceptance accounted for more variance in predicting desired fertility than did the Bem Sex Role Inventory.…

  13. Thematic Role Properties of Subjects and Objects

    ERIC Educational Resources Information Center

    Kako, Edward

    2006-01-01

    This paper tests two claims about the thematic roles Agent and Patient: first, that they can be decomposed into more primitive features, as laid out in Dowty's (1991) Proto-Roles Hypothesis; and second, that these properties can be inferred directly from the grammatical roles subject and object. In Experiments 1 and 2, participants rated the…

  14. Psychological Consequences of Multiple Social Roles.

    ERIC Educational Resources Information Center

    Pietromonaco, Paula R; And Others

    1986-01-01

    Explored consequences of having mulitiple roles. Questioned 500 employed women about self-esteem; satisfaction with careers, partners, and children; perceptions of life stress and pleasure; and number of roles held. Higher self-esteem and greater job satisfaction were associated with holding more roles. Marital and parental satisfaction were not…

  15. Marital Role Strain and Sexual Satisfaction.

    ERIC Educational Resources Information Center

    Frank, Ellen; And Others

    1979-01-01

    Responses to a questionnaire pertaining to discrepancies between an individual's ideal and actual marital role behaviors and level of sexual satisfaction indicated lower levels of role strain in nonpatient couples. A higher level of role strain correlated with increased sexual dissatisfaction. (Author)

  16. Identifying Role Diffusion in School Counseling

    ERIC Educational Resources Information Center

    Astramovich, Randall L.; Hoskins, Wendy J.; Gutierrez, Antonio P.; Bartlett, Kerry A.

    2013-01-01

    Role ambiguity in professional school counseling is an ongoing concern despite recent advances with comprehensive school counseling models. The study outlined in this article examined role diffusion as a possible factor contributing to ongoing role ambiguity in school counseling. Participants included 109 graduate students enrolled in a…

  17. Role Interaction: The Salt in the Soup.

    ERIC Educational Resources Information Center

    Kilbane-Flash, Marian T.

    This case study illustrates and expands upon the principle that innovation efforts involve both role change and change in role interrelationships, changes that (ideally) will be supportive of the innovation effort, but which may--if duplication, gaps among roles, or tension arise--weaken or destroy the effort. A planning effort in the Cleveland…

  18. Roles of Variables in Three Programming Paradigms

    ERIC Educational Resources Information Center

    Sajaniemi, J.; Ben-Ari, M.; Byckling, P.; Gerdt, P.; Kulikova, Y.

    2006-01-01

    Roles can be assigned to occurrences of variables in programs according to a small number of stereotypical patterns of use. Studies on explicitly teaching roles to novices learning programming have shown that roles are an excellent pedagogical tool for clarifying the structure and meaning of programs and that their use improves students'…

  19. Roles of Academic Department Chairpersons at the University Level.

    ERIC Educational Resources Information Center

    Kremer-Hayon, Lya; Avi-Itzhak, Tamar E.

    1986-01-01

    A survey of 90 department heads in six Israeli universities concerning their role perceptions, role fulfillment, and satisfaction with role fulfillment found five main role factors and significant differences between fulfillment of roles and the desire to fulfill them. (MSE)

  20. THE ROLE OF THE SCAPULA

    PubMed Central

    Voight, Michael L.

    2013-01-01

    Previously, the scapular musculature was often neglected in designing a rehabilitation protocol for the shoulder. In the past two decades a significant amount of research has been performed in order to help identify the role of the scapula in upper extremity function. Weakness of the scapular stabilizers and resultant altered biomechanics could result in: 1) abnormal stresses to the anterior capsular structures of the shoulder, 2) increased possibility of rotator cuff compression, and 3) decreased shoulder complex neuromuscular performance. This clinical commentary presents facts about the anatomy and biomechanics of the scapula and surrounding musculature, and describes the pathomechanics of scapular dysfunction. The focus is upon the assessment of dysfunction and retraining of the scapular musculature. Level of Evidence: 5 PMID:24175141

  1. Developmental roles of brain histamine.

    PubMed

    Panula, Pertti; Sundvik, Maria; Karlstedt, Kaj

    2014-03-01

    Histamine appears early during brain development, has been shown to regulate fetal and adult brain-derived stem cells in a receptor type-dependent manner, and has widespread actions on systems involved in arousal and movement. Developmental studies in both rodents and zebrafish have elucidated the spatiotemporal patterning of the histaminergic system and, in zebrafish, have revealed the mechanisms whereby histamine regulates the number of hypocretin/orexin (hcrt) neurons, which in turn may regulate the number of histaminergic cells. Recent demonstrations of increased numbers of histaminergic neurons in patients with narcolepsy highlight the importance, for our understanding of both normal and pathological brain function, of understanding these interactions. Here, we review recent research into the developmental roles of histamine and suggest key areas for future research. PMID:24486025

  2. The Role of Coherent Detection

    NASA Technical Reports Server (NTRS)

    Zmuidzinas, J.

    2004-01-01

    Many interesting astronomical objects, such as galaxies, molecular clouds, PDRs, star - forming regions, protostars, evolved stars, planets, and comets, have rich submillimeter spectra. In order to avoid line blending, and to be able to resolve the line shape, it is often necessary to measure these spectra at high resolution. This paper discusses the relative advantages and limitations of coherent and direct detection for high resolution spectroscopy in the submillimeter and far - infrared. In principle, direct detection has a fundamental sensitivity advantage. In practice, it is di.cult to realize this advantage given the sensitivities of existing detectors and reasonable constraints on the instrument volume. Thus, coherent detection can be expected to play an important role in submillimeter and far - infrared astrophysics well into the future.

  3. Roles of the Team Physician.

    PubMed

    Kinderknecht, James

    2016-07-01

    The roles of the team physician are much more than providing medical coverage at a sport's event. The team physician has numerous administrative and medical responsibilities. The development of an emergency action plan is an essential administrative task as an example. The implementation of the components of this plan requires the team physician to have the necessary medical knowledge and skill. An expertise in returning an athlete to play after an injury or other medical condition is a unique attribute of the trained team physician. The athlete's return to participation needs to start with the athlete's safety and best medical interests but not inappropriately restrict the individual from play. The ability to communicate on numerous levels needs to be a characteristic of the team physician. There are several potential ethical conflicts the team physician needs to control. These conflicts can create unique medicolegal issues. The true emphasis of the team physician is to focus on what is best for the athlete. PMID:27322925

  4. [Role of RAS in prehypertension].

    PubMed

    Inaba, Shinji; Iwai, Masaru; Horiuchi, Masatsugu

    2008-08-01

    Hypertension has long been recognized as a major risk factor of several cardiovascular diseases. It is well known that the renin-angiotensin system(RAS) is involved in the pathogenesis of both hypertension and hypertensive end-organ damage. Untreated hypertension is self-accelerating condition through RAS stimulation. Activation of RAS contributes to the transition from borderline hypertension to established hypertension. Recently, "the Seventh Report of Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC 7)" proposed a new classification of borderline blood pressure levels, as "prehypertension". The therapeutic focus has begun to shift from the therapy of established hypertension to the prevention of hypertension. This review addressed the relationship between hypertension, prehypertension and the role of RAS. PMID:18700549

  5. Role of Astrocytes in Epilepsy

    PubMed Central

    Coulter, Douglas A.; Steinhäuser, Christian

    2016-01-01

    Astrocytes express ion channels, transmitter receptors, and transporters and, thus, are endowed with the machinery to sense and respond to neuronal activity. Recent studies have implicated that astrocytes play important roles in physiology, but these cells also emerge as crucial actors in epilepsy. Astrocytes are abundantly coupled through gap junctions allowing them to redistribute elevated K+ and transmitter concentrations from sites of enhanced neuronal activity. Investigation of specimens from patients with pharmacoresistant temporal lobe epilepsy and epilepsy models revealed alterations in expression, localization, and function of astroglial K+ and water channels. In addition, malfunction of glutamate transporters and the astrocytic glutamate-converting enzyme, glutamine synthetase, has been observed in epileptic tissue. These findings suggest that dysfunctional astrocytes are crucial players in epilepsy and should be considered as promising targets for new therapeutic strategies. PMID:25732035

  6. [Diagnostic role of galectin-3].

    PubMed

    Gudowska, Monika; Chrostek, Lech

    2014-12-01

    The meaning of galectin-3 role in the diagnostics of different diseases was disscused in the paper. Galectin-3 is endogenous, soluble beta- galactoside-binding lectin, which occur in the cell nucleus, the cytoplasm and on the surface of certain cells. Galectin-3 controls cell cycle, modulates adhesion, affects the mRNA splicing, extracellular matrix interactions and cellular differentiation. Galectin-3, also affects to procollagen I which irreversibly crosslinks to form collagen and results in parenchymal organs fibrosis. Taking into account numerous research and knowledge of action mechanism of galectin-3 there were presented changes in its activity in the pathological processes of the human body, including: heart failure, liver fibrosis and tumors. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables to application in laboratory diagnosis. PMID:25715576

  7. Psychiatrists' Perceptions of Role-Playing Games.

    PubMed

    Lis, Eric; Chiniara, Carl; Biskin, Robert; Montoro, Richard

    2015-09-01

    The literature has seen a surge in research on the mental health impacts of technologies such as Facebook, video games, and massively-multiplayer online role-playing games such as World of Warcraft, but little is known regarding the mental health impact of non-video role-playing games, such as Dungeons & Dragons. The present study examines how psychiatrists' perceive role-playing games and whether they play them. Psychiatrists at a tertiary care centre in Canada completed a questionnaire assessing history of playing role-playing games and whether they associate them with psychopathology. Forty-eight psychiatrists responded. Twenty-three percent have played a role-playing game over their lifetimes. Twenty-two percent believed there was an association between psychopathology and role-playing games. A majority of psychiatrists who responded do not associate role-playing games with psychopathology. Implications for clinical practice and future research are discussed. PMID:25589035

  8. Curriculum change: the importance of team role.

    PubMed

    Broomfield, D; Bligh, J

    1997-03-01

    This paper describes a study examining aspects of team role in the management of curriculum change. The Belbin Team Role Self-Perception Inventory was completed by 25 members (83%) of a faculty curriculum development team. Overall the group showed a preference for the implementer and shaper roles, whilst the completer-finisher role was relatively weakly represented, ranking fifth out of eight possible roles. Older and more senior team members favoured the co-ordinator role, whilst younger and more junior members favoured the team-worker and completer-finisher roles. Some implications of these findings are discussed in the light of the current trend for widespread change in undergraduate medical curricula and the challenges faced by medical schools in a resource constrained environment. PMID:9231114

  9. Réflexions sur lʼavenir de lʼénergie nucléaire, de la France dʼaujourdʼhui au monde de demain : IIe à IVe générations

    NASA Astrophysics Data System (ADS)

    Dautray, Robert; Friedel, Jacques; Bréchet, Yves

    2012-06-01

    The recent events at the Fukushima power plants (PP) have brought to light key issues which have to be discussed concerning the position of nuclear energy in the energy mix, in the context of global warming, of waning petroleum resources, of an increasing world population, and of its industrial development. These questions are addressed here from the viewpoint of physical facts; and, without proposing definite choices, this article aims to provide information on the equipment required to benefit from the fission chain reaction, while explaining the possible incidents and accidents, and the possible hidden military misuse of nuclear matter. Specific issues, such as risk assessment and risk management, will be considered, under the constraints of dealing with international non-proliferation safeguards and France energy resources independence. A special emphasis will be given on the fuel cycle, on the variety of time scales involved, and on the requirements of developing the next generation of nuclear power plants, and more specifically the fast breeder option. The lessons to be drawn from the Fukushima accident, resulting mainly from the residual power of used fuel and the loss of cooling source, are outlined, and the consequences to be drawn about the various relevant time scales are emphasized.

  10. From "Mentor" to "Role Model": Scaling the Involvement of STEM Professionals through Role Model Videos

    ERIC Educational Resources Information Center

    Ware, Jennifer; Stein, Sarah

    2013-01-01

    Mentors and role models can play a significant role in high school students' motivation to pursue specific careers later in life. Although the use of role models in the classroom is an important research topic, little research has been conducted on scaling up STEM role models reach through the use of video vignettes. This essay outlines a series…

  11. The "Role" of Burnout among Special Educators: The Relationship between Burnout and Role Tensions.

    ERIC Educational Resources Information Center

    Edmonson, Stacey L.; Thompson, David P.

    This paper discusses the outcomes of a meta-analysis that reviewed primary studies from eight major databases to investigate the impact of role ambiguity and conflict in the burnout of special education teachers. Five role constructs were found to be present in the literature on burnout among special educators: role ambiguity, role conflict, role…

  12. Unemployment and health: physicians' role.

    PubMed

    Guirguis, S S

    1999-01-01

    Unemployment has been documented to have detrimental impacts on a person's mental, physical and social well being. When unemployment or being out of work is due to injury or sickness, the effects are compounded by mental and social factors. In an effort to prevent prolonged unemployment due to injury or sickness, changes were made to existing disability income supplement plans to redirect their focus from basic income support to active employment measures. This is intended to reduce individual's dependency on financial assistance and encourage individuals to take personal responsibility for getting back to work. The various disability insurance plans require primary care physicians to provide opinion and participate in the recovery and safety return to work of injured or sick persons. The physician approach to medical care of the injured/sick person with employment problems should focus on return to work as a goal of treatment. The patient should be seen as part of a social or environmental system and not as an isolated individual. The physician has a significant role to play in the diagnosis, determining functional abilities and participation in the return to work plan. The physician positive participation, not only provides an intrinsic cost saving value in insurance costs, but more important, helps patients maintain gainful employment. Work often helps in regaining health. Many factors are involved in a return to work outcome and physicians need to know how to identify and track the factors that facilitate or impede return to work. The challenge for the physician is to utilize the available resources to facilitate the recovery and communicate with other parties involved in the return to work process. This paper discusses the disability insurance plans in Canada and the community expectations from physicians dealing with patients who are out of work because of injury or sickness. It is acknowledged that primary care physicians' skills are not adequate in this

  13. Atom-Role-Based Access Control Model

    NASA Astrophysics Data System (ADS)

    Cai, Weihong; Huang, Richeng; Hou, Xiaoli; Wei, Gang; Xiao, Shui; Chen, Yindong

    Role-based access control (RBAC) model has been widely recognized as an efficient access control model and becomes a hot research topic of information security at present. However, in the large-scale enterprise application environments, the traditional RBAC model based on the role hierarchy has the following deficiencies: Firstly, it is unable to reflect the role relationships in complicated cases effectively, which does not accord with practical applications. Secondly, the senior role unconditionally inherits all permissions of the junior role, thus if a user is under the supervisor role, he may accumulate all permissions, and this easily causes the abuse of permission and violates the least privilege principle, which is one of the main security principles. To deal with these problems, we, after analyzing permission types and role relationships, proposed the concept of atom role and built an atom-role-based access control model, called ATRBAC, by dividing the permission set of each regular role based on inheritance path relationships. Through the application-specific analysis, this model can well meet the access control requirements.

  14. Functional Role of Ribosomal Signatures

    PubMed Central

    Chen, Ke; Eargle, John; Sarkar, Krishnarjun; Gruebele, Martin; Luthey-Schulten, Zaida

    2010-01-01

    Although structure and sequence signatures in ribosomal RNA and proteins are defining characteristics of the three domains of life and instrumental in constructing the modern phylogeny, little is known about their functional roles in the ribosome. In this work, the largest coevolving RNA/protein signatures in the bacterial 30S ribosome are investigated both experimentally and computationally through all-atom molecular-dynamics simulations. The complex includes the N-terminal fragment of the ribosomal protein S4, which is a primary binding protein that initiates 30S small subunit assembly from the 5′ domain, and helix 16 (h16), which is part of the five-way junction in 16S rRNA. Our results show that the S4 N-terminus signature is intrinsically disordered in solution, whereas h16 is relatively stable by itself. The dynamic disordered property of the protein is exploited to couple the folding and binding process to the five-way junction, and the results provide insight into the mechanism for the early and fast binding of S4 in the assembly of the ribosomal small subunit. PMID:21156135

  15. Biological roles of fungal carotenoids.

    PubMed

    Avalos, Javier; Carmen Limón, M

    2015-08-01

    Carotenoids are terpenoid pigments widespread in nature, produced by bacteria, fungi, algae and plants. They are also found in animals, which usually obtain them through the diet. Carotenoids in plants provide striking yellow, orange or red colors to fruits and flowers, and play important metabolic and physiological functions, especially relevant in photosynthesis. Their functions are less clear in non-photosynthetic microorganisms. Different fungi produce diverse carotenoids, but the mutants unable to produce them do not exhibit phenotypic alterations in the laboratory, apart of lack of pigmentation. This review summarizes the current knowledge on the functional basis for carotenoid production in fungi. Different lines of evidence support a protective role of carotenoids against oxidative stress and exposure to visible light or UV irradiation. In addition, the carotenoids are intermediary products in the biosynthesis of physiologically active apocarotenoids or derived compounds. This is the case of retinal, obtained from the symmetrical oxidative cleavage of β-carotene. Retinal is the light-absorbing prosthetic group of the rhodopsins, membrane-bound photoreceptors present also in many fungal species. In Mucorales, β-carotene is an intermediary in the synthesis of trisporoids, apocarotenoid derivatives that include the sexual hormones the trisporic acids, and they are also presumably used in the synthesis of sporopollenin polymers. In conclusion, fungi have adapted their ability to produce carotenoids for different non-essential functions, related with stress tolerance or with the synthesis of physiologically active by-products. PMID:25284291

  16. Role of infections in atherosclerosis.

    PubMed

    Valtonen, V V

    1999-11-01

    A growing amount of epidemiologic, experimental, and clinical evidence has linked infection as a risk factor to variousatherosclerotic diseases including acute myocardial infarction and cerebral infarction. Bacteremic infections with and without endocarditis carry a high risk for both stroke and acute myocardial infarction. During the last decade, chronic bacterial infections such as Chlamydia pneumoniae and dental infections have been associated as risk factors for various atherosclerotic diseases. These chronic bacterial infections are risk factors for acute cardiovascular events, but they may also have some role in the etiopathogenesis of atherosclerotic process itself. There are many known mechanisms that might explain the observed association of infection and atherosclerotic diseases, but it is probable that these mechanisms are complex and multifactorial and probably differ from infection to infection and from patient to patient. Infection theory is by no means against classic risk factor theory in the etiopathogenesis of atherosclerosis. Infection may also act as a synergistic risk factor together with classic risk factors in the development of various atherosclerotic diseases. PMID:10539842

  17. Men's role. Developing public opinion.

    PubMed

    Song, Y

    1994-03-01

    With most couples in China currently bearing only 1-2 children, the average couple must practice family planning for more than 20-30 years. An extremely high level of cooperation is therefore required between husband and wife to realize this level of fertility. The Vice-Chairman of the Standing Committee of the National People's Congress stresses that men should take a greater role in family planning. Women, like men, work to contribute to family income, but they also become pregnant, give birth, breastfeed, and rear children. Men should really share some responsibilities of family planning to alleviate some degree of burden borne by women. In particular, men could opt to be sexually sterilized to eliminate the potential for any further unwanted fertility as a result of their continued sexual intercourse. The process of male sterilization is easier and safer than female sterilization with the Li method of male sterilization requiring only an injection into the seminal passage to prevent the further emission of semen. The vice-chairman notes that more than 15 million men voluntarily underwent male sterilization in Sichuan province, thus accounting for half of male sterilization cases in the world. Not everyone, however, should accept sterilization, but efforts could nonetheless be made to encourage men to accept greater responsibility for the control of their fertility. PMID:12287782

  18. Ritual's role in profound change.

    PubMed

    1995-03-01

    In today's healthcare environment, characterized by downsizing, restructuring, mergers, and acquisitions, organizational cultures and employees are experiencing rapid--and often tense--changes. Ritual can facilitate change by acknowledging it and allowing the grieving process to take its course. The success of an organizational culture change can depend on whether the organization and its members have been given an opportunity to grieve. Until they grieve their losses, people cannot embrace the new. Organizational leaders who have survived downsizing must come to grips with their own survivor status first and then lead others in the organization through the current painful but irrevocable shift in their relationship to the organization. The use of ritual helps organizational survivors see the connection between the grieving process and their survivor symptoms of denial, anger, depression, guilt, fear, insecurity, anxiety, and uncertainty. A good ritual should allow those present to rise above barriers that separate, worries that overburden, and blindness that limits and to gather as one with God. As a rule, a good ritual is participative and recognizes the audience's diversity. The ritual should not just address those present but invite them to act, pray, or sing. Ritual is an important way to provide a structure that allows people to express their emotions. For leaders, it can be a visible way to acknowledge grief and show support for organizational members. For ritual to have any meaning, key leaders need to be present and perhaps have a role in the creation and enactment of the ritual. PMID:10146160

  19. Role of LCAT in Atherosclerosis.

    PubMed

    Ossoli, Alice; Simonelli, Sara; Vitali, Cecilia; Franceschini, Guido; Calabresi, Laura

    2016-01-01

    Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. However, despite the fact that it has been more than 50 years since the identification of LCAT, the role of this enzyme in the pathogenesis of atherosclerosis is still debated. A number of studies have been conducted in different animal models, with contradictory results. Studies in humans, in particular in the general population, in subjects at high cardiovascular risk, and in carriers of genetic LCAT deficiency in an excellent model to evaluate the correlation between the reduction of LCAT activity and atherosclerosis also gave conflicting results. This review provides a comprehensive overview of the controversial findings obtained in animals and humans, strengthening the necessity of further investigation to establish how LCAT could be regulated in a promising therapeutic strategy to reduce cardiovascular risk. PMID:26607351

  20. Educating nurses for leadership roles.

    PubMed

    Heller, Barbara R; Drenkard, Karen; Esposito-Herr, Mary Beth; Romano, Carol; Tom, Sally; Valentine, Nancy

    2004-01-01

    As a result of the growing shortage of nurses and the dramatically changing role of the front-line nurse manager, leadership education for nurses is of critical importance. The purpose of the project described in this article was to design, implement, and evaluate an innovative model of nursing leadership development for students enrolled in registered nurse to bachelor of science in nursing or registered nurse to master of science in nursing programs. A guided "action-learning" course was designed that focused on both core knowledge and experiential learning. The course was developed with the assistance of an advisory panel of prominent nurse leaders with expertise in administration, health policy, informatics, and nursing education. The prototype course was offered for the first time as an elective in Spring 2003. Evaluation data indicated that the course was considered valuable by students and with modifications suggested by students, faculty, and advisory panel members, the course would be offered regularly as part of the curriculum. Recommendations also included adapting course content to a continuing education format. PMID:15481400

  1. Role of carnitine in disease

    PubMed Central

    2010-01-01

    Carnitine is a conditionally essential nutrient that plays a vital role in energy production and fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters. Distinct deficiencies arise either from genetic mutation of carnitine transporters or in association with other disorders such as liver or kidney disease. Carnitine deficiency occurs in aberrations of carnitine regulation in disorders such as diabetes, sepsis, cardiomyopathy, malnutrition, cirrhosis, endocrine disorders and with aging. Nutritional supplementation of L-carnitine, the biologically active form of carnitine, is ameliorative for uremic patients, and can improve nerve conduction, neuropathic pain and immune function in diabetes patients while it is life-saving for patients suffering primary carnitine deficiency. Clinical application of carnitine holds much promise in a range of neural disorders such as Alzheimer's disease, hepatic encephalopathy and other painful neuropathies. Topical application in dry eye offers osmoprotection and modulates immune and inflammatory responses. Carnitine has been recognized as a nutritional supplement in cardiovascular disease and there is increasing evidence that carnitine supplementation may be beneficial in treating obesity, improving glucose intolerance and total energy expenditure. PMID:20398344

  2. Differential Roles of PML Isoforms.

    PubMed

    Nisole, Sébastien; Maroui, Mohamed Ali; Mascle, Xavier H; Aubry, Muriel; Chelbi-Alix, Mounira K

    2013-01-01

    The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of APL patients with arsenic trioxide (As2O3) reverses the disease phenotype by a process involving the degradation of the fusion protein via its PML moiety. Several PML isoforms are generated from a single PML gene by alternative splicing. They share the same N-terminal region containing the RBCC/tripartite motif but differ in their C-terminal sequences. Recent studies of all the PML isoforms reveal the specific functions of each. Here, we review the nomenclature and structural organization of the PML isoforms in order to clarify the various designations and classifications found in different databases. The functions of the PML isoforms and their differential roles in antiviral defense also are reviewed. Finally, the key players involved in the degradation of the PML isoforms in response to As2O3 or other inducers are discussed. PMID:23734343

  3. Approches interlinguistiques de la complementation verbale: Quels savoirs pour l'enseignant? Quels savoirs pour l'eleve? (Interlinguistic Approaches to Object-Verb Complementation: What the Teacher Needs To Know? What the Student Needs To Know?).

    ERIC Educational Resources Information Center

    Beguelin, Marie-Jose, Ed.; de Pietro, Jean-Francois, Ed.; Naf, Anton, Ed.

    2002-01-01

    This issue deals with verb-object complementation, a complex and controversial but important topic, in particular in connection with the teaching and learning of a second language. The articles are a response to a long debate about the harmonization of grammatical terminology used in schools and the simplification of grammar for students. The…

  4. Etiology of maternal-student role stress.

    PubMed

    Gigliotti, Eileen

    2004-04-01

    This paper details the refinement and testing of a proposition regarding the age-related effects of psychological involvement in both the maternal role and the student role, and total network support on maternal-student role stress. Results of hierarchical multiple regression analysis showed that the independent variables contribute to an explanation of maternal-student role stress only for women aged 37 years and older. The proposition was further refined. It supports the propositions of both Neuman's systems model and Meleis et al.'s transition framework. Implications for research and practice are discussed. PMID:15090092

  5. Taxonomy of the nuclear plant operator's role

    SciTech Connect

    Kisner, R.A.; Fullerton, A.M.; Frey, P.R.; Dougherty, E.M.

    1981-01-01

    A program is presently under way at the Oak Ridge National Laboratory (ORNL) to define the functional design requirements of operational aids for nuclear power plant operators. A first and important step in defining these requirements is to develop an understanding of the operator's role or function. This paper describes a taxonomy of operator functions that applies during all operational modes and conditions of the plant. Other topics such as the influence of automation, role acceptance, and the operator's role during emergencies are also discussed. This systematic approach has revealed several areas which have potential for improving the operator's ability to perform his role.

  6. Marketing the Changing Role of the SLMS.

    ERIC Educational Resources Information Center

    Freels, Judy; Kruse, Claire; Richards, David; Sophiea, Laura

    2001-01-01

    School library media specialists (SLMSs) in the Rochester (Michigan) Community Schools decided it was crucial to come to a consensus about key roles of SLMSs in successful school library media programs. They identified the following roles: information specialist, instructional partner, and program administrator. To educate administrators, staff…

  7. Roles in Literacy Learning: A New Perspective.

    ERIC Educational Resources Information Center

    Tovey, Duane R., Ed.; Kerber, James E., Ed.

    Refining and better understanding the roles parents, teachers, administrators, and researchers play in helping children learn to process written language is the focus of this book. Part 1 considers the role of the parents and includes the following articles: "Learning to Read: It Starts in the Home" (David B. Doake): "Let's Read Another One"…

  8. Veterinary Science Departments: Their Role in Academia

    ERIC Educational Resources Information Center

    Curtin, Terrence M.

    1977-01-01

    The roles played by veterinary science departments are creditable and important, says this head of a department of veterinary science. Those roles will reflect an absolute increase in participation with veterinary schools on a regional and national basis, and a relative increase in direct involvement in veterinary education. (LBH)

  9. Students' Roles during Peer Response Sessions

    ERIC Educational Resources Information Center

    Lin, Sandra Sim Phek; Samuel, Moses

    2013-01-01

    This study examined the types of roles played by students during peer response sessions and investigated how the students' roles facilitated learning. This qualitative case study involved six Grade 10 mixed-proficiency level students from a secondary school in Malaysia. Data were collected through multiple sources. The findings indicated that the…

  10. CTE's Role in Workforce Readiness Credentialing

    ERIC Educational Resources Information Center

    Hyslop, Alisha

    2008-01-01

    The career and technical education (CTE) programs play critical roles in the growth of workforce readiness credentials. This article presents an ACTE issue brief that highlighting the need for workforce readiness credentials, and the role CTE plays in helping students acquire them. CTE is at the forefront of preparing students at all levels for…

  11. Development of Mentor Teacher Role Inventory

    ERIC Educational Resources Information Center

    Koc, Ebru Melek

    2011-01-01

    This study aimed to develop and investigate the validity and reliability of the Mentor Teacher Role Inventory (MTRI). A total of 1843 student teachers in the Distance English Teacher Training Program participated in the study. The 58 items of the Mentor Teacher Role Inventory underwent principal factor analysis, which revealed nine factors…

  12. Roles, Responsibilities, and Qualifications for Reading Specialists.

    ERIC Educational Resources Information Center

    International Reading Association, Newark, DE.

    This document presents in outline form the roles, responsibilities, and qualifications of reading specialists as formulated by the Professional Standards and Ethics Committee and approved by the Board of Directors of the International Reading Association. The breakdown of roles, which are retained as outline headings in the sections on…

  13. The Role of the Primary School Head.

    ERIC Educational Resources Information Center

    Davies, Lester

    1987-01-01

    This study uses Henry Mintzberg's structural observation method to examine British primary school head teachers' work patterns and determine the nature of their role. Head teachers' days were characterized by brevity, variety, and fragmentation similar to those discussed in findings of other empirical managerial studies. Leadership roles stressed…

  14. Sex Role Socialization in Early Childhood.

    ERIC Educational Resources Information Center

    Katz, Lilian G.; And Others

    This paper reviews the theory and research related to the sex role socialization of young children, specifically addressing a range of theoretical and practical issues related to the implementation of the Women's Educational Equity Act. Section I examines the influence of the family on children's sex role development, focusing on differentiated…

  15. ROLE-PLAYING AND THE POOR.

    ERIC Educational Resources Information Center

    GOLDFARB, JEAN; RIESSMAN, FRANK

    ROLE-PLAYING IS A VALUABLE TECHNIQUE FOR WORKING WITH DISADVANTAGED PEOPLE BECAUSE IT IS CONGENIAL WITH THE LOW-INCOME PERSON'S STYLE. ROLE-PLAYING ALLOWS THE PRACTITIONER TO REDUCE THE DISTANCE BETWEEN HIMSELF AND THE DISADVANTAGED, IT PERMITS MORE LEARNING ABOUT THE CULTURE OF THE LOW-INCOME PERSON FROM THE "INSIDE," AND IT IS AN EXCELLENT…

  16. Origins of Sex-Role Development.

    ERIC Educational Resources Information Center

    Lewis, Michael; Weintraub, Marsha

    1979-01-01

    Development in general, and sex-role behavior in particular, is influenced by both biological and environmental factors. However, the coalescence of these factors around the child's growing social cognitive abilities is the critical factor in the development of sex role behavior. (Author/EB)

  17. A Leadership Role for Library Media Specialists.

    ERIC Educational Resources Information Center

    Crowley, John

    1995-01-01

    Discusses the role of library media specialists in education. Highlights include assessing the effect of media specialists on learning outcomes; sexism; educational change; and strategic planning for media centers and for schools, including a paradigm shift for media specialists to assume a leadership role in the educational community. (LRW)

  18. Using Role Play to Debate Animal Testing

    ERIC Educational Resources Information Center

    Agell, Laia; Soria, Vanessa; Carrió, Mar

    2015-01-01

    The use of animals in biomedical research is a socio-scientific issue in which decision-making is complicated. In this article, we describe an experience involving a role play activity performed during school visits to the Barcelona Biomedical Research Park (PRBB) to debate animal testing. Role playing games require students to defend different…

  19. Personality Correlates of Social Role Range.

    ERIC Educational Resources Information Center

    McReynolds, Paul; And Others

    The concept of social role range (SRR) deals with the magnitude of an individual's repertoire of different interpersonal behavior patterns and exhibits the properties of a personality trait. Over a broad range of interpersonal settings, individuals tend to be consistent in the magnitude of their SRR's. A role play technique was devised for…

  20. Preparing Change Agents for Change Agent Roles.

    ERIC Educational Resources Information Center

    Sedlacek, James R.

    Seventy-seven Spanish- and Portuguese-speaking agricultural change agents from developing Central and South American countries responded to a questionnaire which sought perceptions of the roles in which the change agents felt they were involved and the roles for which they felt they were being trained. The agents were participating in training…

  1. Children's Sextyped Views of Traditional Occupational Roles.

    ERIC Educational Resources Information Center

    Barnhart, Ruth S.

    1983-01-01

    Examined children's views of traditional occupations in a study of 300 elementary school students who viewed photographs of 18 occupations. Results showed for most of the 18 occupational roles, students chose a traditional male or female role. The occupations of homemaker and firefighter received the most stereotyped scores. (JAC)

  2. Opening Trade Barriers: Sex Role Awareness Tools.

    ERIC Educational Resources Information Center

    Goldstein, Rikki

    This manual consists of exercises to explore sex-role stereotyping as it affects work roles. They are intended to make young people aware of career opportunities in nontraditional fields. The 10 exercises include the following: values clarification; true-false quiz about sex characteristics and occupational requirements; character traits…

  3. Role Strain in University Research Centers

    ERIC Educational Resources Information Center

    Boardman, Craig; Bozeman, Barry

    2007-01-01

    One way in which university faculty members' professional lives have become more complex with the advent of contemporary university research centers is that many faculty have taken on additional roles. The authors' concern in this article is to determine the extent to which role strain is experienced by university faculty members who are…

  4. The Roles and Challenges of Deans.

    ERIC Educational Resources Information Center

    Montez, Joni Mina; Wolverton, Mimi; Gmelch, Walter H.

    2003-01-01

    Using data from the National Study of Academic Deans, examined the relationships between academic deans' roles, conflict, and ambiguity, postulating that the same roles in which they engage today will be challenges in the future unless conflict and ambiguity are lessened. Discusses the implications of these issues and recommends strategies for…

  5. Technological Dependency, Role Stress, and Strain.

    ERIC Educational Resources Information Center

    Caplan, Robert D.; Jones, Kenneth W.

    This study grew out of interest in how occupational role stress, moderated by personality, affects health--particularly in the area of coronary heart disease. People in organizations are now asking how occupational role demands and technological developments affect employee health. This study examined the effects of an impending shutdown of the…

  6. Key Roles in the Revolution of Work.

    ERIC Educational Resources Information Center

    Riverin-Simard, Danielle

    At the height of the work revolution and its great social challenges, career development and employment counseling specialists have essential key roles to play in order to support the socioeconomic growth of our community. This book suggests four pro-active key roles for the profession. This recommendation is based on research conducted over the…

  7. Higher Education Leadership Roles in Knowledge Processing

    ERIC Educational Resources Information Center

    Martin, Jeffery S.; Marion, Russell

    2005-01-01

    Purpose: To examine the critical roles of leadership in higher education and to define how such roles enable an environment that embraces the demands of a knowledge-based organization. Design/methodology/approach: Through interviews with executive leadership in several higher education institutions, the ontology of knowledge management was…

  8. Licensed Practical Nurses' Sex Role Stereotypes.

    ERIC Educational Resources Information Center

    Wallston, Barbara Strudler; And Others

    1983-01-01

    Examined whether sex-role stereotypes would affect nurses' (N=32) attitudes toward simulations of male and female patients. Emotional style and patients' diagnosis were manipulated. Results showed significant sex-role differences and stereotypical attitudes. Male patients were rated more positively, and were more likely to possess traditional male…

  9. Making a role for nurses in CCGs.

    PubMed

    Moore, Alison

    2016-07-13

    What do nurses in clinical commissioning groups (CCGs) do? The answer is lots, but their role and influence varies greatly between CCGs. In May, a report from NHS Clinical Commissioners (NHSCC) - the membership organisation of CCGs - highlighted the key responsibilities of nurses and the important contribution they make in what are often pressured and demanding roles (see tinyurl.com/CCG-nurses ). PMID:27406497

  10. Roles for vitamin K beyond coagulation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent interest in vitamin K has been motivated by evidence of physiological roles beyond that of coagulation. Vitamin K and vitamin K-dependent proteins may be involved in regulation of calcification, energy metabolism, and inflammation. However, the evidence for many of these proposed roles in the...

  11. Sex Role Stereotypes Are Alive and Well.

    ERIC Educational Resources Information Center

    Snodgrass, Sara E.

    Two studies, in late 1988 and early 1990, examined sex-role stereotypes held by northeastern liberal arts college students (N=719) and southern state university college students (N=145). The first study used the Personal Attributes Questionnaire (PAQ) and compared ratings of men and women with the traditional sex-roles represented by the PAQ in…

  12. Health Educators: Role Modeling and Smoking Behavior.

    ERIC Educational Resources Information Center

    Brennan, Andrew J. J.; Galli, Nicholas

    1985-01-01

    Examined cigarette smoking among health educators, their views about the effects of this behavior upon their audiences and beliefs about smoking in light of their professional role. Smokers and nonsmokers were significantly less included than former smokers to feel the role of health education is to convince people not to smoke. (Author/ABL)

  13. Role-Playing Methods in the Classroom.

    ERIC Educational Resources Information Center

    Chesler, Mark; Fox, Robert

    This book, one of three Teacher Resource Booklets on Classroom Social Relations and Learning developed at the Center for Research on Utilization of Scientific Knowledge at the University of Michigan, discusses the theoretical background of role playing and gives a step-by-step discussion of how to use role playing in the classroom. There are…

  14. Faculty Role Categories: A Dean's Management Challenge

    ERIC Educational Resources Information Center

    Harvey, Michael G.; Sigerstad, Thomas; Kuffel, Thomas S.; Novicevic, Milorad M.; Keaton, Paul N.

    2006-01-01

    In this article, the authors' goal was to examine faculty roles from a role-theoretic perspective based on a typology of faculty categories. Based on an assessment of specific faculty needs within each category, the authors proposed a differentiated management model for academic deans to address specific segments of the faculty work environment.…

  15. Preterm labor: role of the nurse practitioner.

    PubMed

    Doyle, Jennifer; Silber, Angela

    2015-03-12

    The nurse practitioner may play a pivotal role in diagnosing preterm labor through risk assessment and physical exam. While treatment and management of preterm labor are usually beyond the nurse practitioner's scope of practice, they can play an important role in preventing preterm birth through assessment, action, or advocacy. PMID:25585096

  16. The Federal Role in Postsecondary Education.

    ERIC Educational Resources Information Center

    Hodgkinson, Virginia A.

    The federal role in postsecondary education since 1787 is traced. Attention is directed to the types of indirect federal support toward postsecondary education until the first Higher Education Act of 1965, and the kinds of national priorities served by the current federal role in postsecondary education. Future projections and the implications of…

  17. Personality Characteristics and Evaluation of Women's Role.

    ERIC Educational Resources Information Center

    Welsh, Mary C.; Hawker, James

    The relationships between several commonly utilized women's role questionnaires and several personality inventories was investigated. Undergraduates students (120 females, 80 males) completed several personality and sex-role questionnaires including the Personal Orientation Inventory (POI); Rotter's Locus of Control Scale (I-E), MAFERR Forms A, B,…

  18. Probation's role in offender mental health.

    PubMed

    Sirdifield, Coral; Owen, Sara

    2016-09-12

    Purpose The purpose of this paper is to examine how the role in offender mental health for the probation service described in policy translates into practice through exploring staff and offenders' perceptions of this role in one probation trust. In particular, to examine barriers to staff performing their role and ways of overcoming them. Design/methodology/approach Qualitative secondary analysis of data from semi-structured interviews with a purposive sample of 11 probation staff and nine offenders using the constant comparative method. Findings Both staff and offenders defined probation's role as identifying and monitoring mental illness amongst offenders, facilitating access to and monitoring offenders' engagement with health services, and managing risk. Barriers to fulfilling this role included limited training, a lack of formal referral procedures/pathways between probation and health agencies, difficulties in obtaining and administering mental health treatment requirements, problems with inter-agency communication, and gaps in service provision for those with dual diagnosis and personality disorder. Strategies for improvement include improved training, developing a specialist role in probation and formalising partnership arrangements. Research limitations/implications Further research is required to explore the transferability of these findings, particularly in the light of the recent probation reforms. Originality/value This is the first paper to explore how staff and offenders perceive probation's role in offender mental health in comparison with the role set out in policy. PMID:27548020

  19. The Principal's Role in Instructional Leadership.

    ERIC Educational Resources Information Center

    Acheson, Keith

    1985-01-01

    The role of principal as supervisor and evaluator of teachers is central to instructional leadership, and this means direct involvement through classroom observation and interaction with each teacher. Principals often neglect this role, with lack of time usually given as the reason. There are other reasons: Interacting with teachers about their…

  20. UNESCO's Role in Global Educational Development

    ERIC Educational Resources Information Center

    Comparative Education Review, 2007

    2007-01-01

    This article presents a two-round discussion that centered around the question: "How well has UNESCO framed its own proposed role in meeting Education for All objectives as well as the roles of other UN organizations, national governments, and civil society actors?" The participants reviewed the most recent draft of UNESCO's "Global Action Plan"…

  1. Working Lesbians: Role Conflicts and Coping Strategies.

    ERIC Educational Resources Information Center

    Shachar, Sandra A.; Gilbert, Lucia A.

    1983-01-01

    Investigated interrole and intrarole conflict reported by lesbian working women (N=79) and factors influencing the types of coping strategies these women used. Responses to a questionnaire showed most interrole conflicts were between the work and lover roles, and intrarole conflicts involved the work and daughter roles. (Author/JAC)

  2. The Smallpox Threat: The School Nurse's Role

    ERIC Educational Resources Information Center

    Martin, Mary E.; Didion, Judy

    2003-01-01

    Today, with the threat of bioterrorism and war, there is a new dimension to the traditional role of the school nurse. The smallpox threat to public health will invoke the school nurse's role as an educator, liaison, and consultant in the community. This article discusses smallpox, the vaccination process, adverse effects, and postvaccination care.…

  3. The Online School Librarian: Roles and Responsibilities

    ERIC Educational Resources Information Center

    Beck, Dennis

    2015-01-01

    Children across the United States of America are maturing in a media-saturated society. Unfortunately, this often results in poor content choices and evaluative skills. North American schools have attempted to address this problem through information literacy skills. One role key to teaching these skills is the role of the school librarian.…

  4. Understanding the Role-Emerging Fieldwork Placement.

    ERIC Educational Resources Information Center

    Bossers, Ann M.; And Others

    1997-01-01

    Students' perceptions (n=11) of role-emerging placements as a learning experience in occupational therapy were explored using qualitative methods. Findings indicate that important learning occurs in the role-emerging experience, which provides opportunities for the development of students as professionals. (Author/JOW)

  5. Adult Children of Dysfunctional Families: Childhood Roles.

    ERIC Educational Resources Information Center

    Jenkins, Stephen J.; And Others

    1993-01-01

    Used retrospective accounts to compare adult children of alcoholics (ACOAs), adults who experienced stressful events in childhood not involving parental alcoholism (A-D+), and adults with no reported dysfunction in family of origin (A-D-) with regard to dysfunctional roles adopted as children. Dysfunctional role adoption was more frequent in ACOA…

  6. Sex-roles in Reading Schemes

    ERIC Educational Resources Information Center

    Lobban, Glenys

    1974-01-01

    Author contended that no broad-ranging study of the way sex-roles are presented in British reading schemes exists. In this article he described a preliminary study on sex-role content in readers in order to remedy this lack of information. (Author/RK)

  7. The Evaluative Role of Participant Observation.

    ERIC Educational Resources Information Center

    Lundsteen, Sara W.

    Participant observation, one of the fieldwork techniques of ethnography, requires a definition of and delicate balance between the roles of participant and observer and a clear understanding of the involvement of the researcher in these two roles. Ethnography is the study of the geographical distribution of people and their relation to their…

  8. Negotiating Researcher Roles in Ethnographic Program Evaluation

    ERIC Educational Resources Information Center

    Harklau, Linda; Norwood, Rachel

    2005-01-01

    We argue for the value of postmodernism in illuminating the roles or subject positions of ethnographic program evaluators. Drawing upon data from an ethnographic study of a summer college readiness program for African American, Asian American, and Anglo youth, we explore how postmodern theories can provide insights into the multiple roles of…

  9. Trends in Counselor Attitude About Women's Roles

    ERIC Educational Resources Information Center

    Engelhard, Patricia Auer; And Others

    1976-01-01

    Counselor attitudes were measured longitudinally to chart attitude changes accompanying increasing career development interests of women. Attitudes examined were: (1) the dual role of mother and worker; (2) perceptions of sex role definition; and (3) expectations regarding the societal impact of women. Changes suggest broader acceptance of sex…

  10. Modelling Focused Learning in Role Assignment.

    ERIC Educational Resources Information Center

    Matessa, Michael; Anderson, John R.

    2000-01-01

    ACT-R is a theory of cognition that is capable of learning the relative usefulness of alternative rules. A model using this implicit procedural learning mechanism is described that explains results from a concept formation task created by McDonald and MacWhinney (1991), a role assignment created by Blackwell (1995), and a new role assignment…

  11. THE ROLE BEHAVIOR OF SCHOOL PRINCIPALS.

    ERIC Educational Resources Information Center

    GROSS, NEAL; AND OTHERS

    THE EFFECTS AND DETERMINANTS OF THREE ROLE BEHAVIOR ASPECTS OF SCHOOL PRINCIPALS WERE STUDIED, AS FOLLOWS--(1) CLOSENESS OF TEACHER SUPERVISION, (2) SUPPORT OF INNOVATION, AND (3) INVOLVEMENT OF PARENTS IN SCHOOL AFFAIRS. SPECIFICALLY, THE EFFECTS AND DETERMINANTS TO BE EXAMINED WERE THE ORGANIZATIONAL EFFECTS OF ROLE BEHAVIOR IN TERMS OF TEACHER…

  12. University-Based Planning: Faculty Advocacy Roles.

    ERIC Educational Resources Information Center

    Harris, William M.; Thagard, Aubrey

    2001-01-01

    Supports the involvement of university planning faculty in advocacy roles as change agents in urban inner city communities, discussing several roles for urban design professionals in the academic context as advocates or contractors (i.e., planner advocacy in community development, in environmental affairs, and in urban design). (SM)

  13. The Role of SENCOs as Leaders

    ERIC Educational Resources Information Center

    Tissot, Catherine

    2013-01-01

    The year 2014 marks an important milestone for the SENCo role. It is the 20-year anniversary of the requirement for schools to have a named person as lead for special educational needs. This article, by Catherine Tissot from the University of Reading, explores the vision of the role as seen in Government guidance and documents and compares this…

  14. The Role of Platelets in Venous Thromboembolism.

    PubMed

    Montoro-García, Silvia; Schindewolf, Marc; Stanford, Sophia; Larsen, Ole Halfdan; Thiele, Thomas

    2016-04-01

    Multiple factors contribute to the risk of venous thromboembolism (VTE). Platelets have attracted much interest in arterial cardiovascular disease, whereas their role in VTE has received much less attention. Recent evidence suggests that platelets may play a more important role in VTE than previously anticipated. This review discusses the mechanisms that link platelets with venous thrombotic disease and their potential applications as novel risk factors for VTE. In addition, animal studies and randomized clinical trials that highlight the potential effect of antiplatelet therapy in venous thrombosis are evaluated to assess the role of platelets in VTE. The clinical significance of platelets for VTE risk assessment in specific patient cohorts and their role as a suitable therapeutic target for VTE prevention is acknowledged. The role of platelets in VTE is a promising field for future research. PMID:26926584

  15. The Relationship between Race and Students' Identified Career Role Models and Perceived Role Model Influence

    ERIC Educational Resources Information Center

    Karunanayake, Danesh; Nauta, Margaret M.

    2004-01-01

    The authors examined whether college students' race was related to the modal race of their identified career role models, the number of identified career role models, and their perceived influence from such models. Consistent with A. Bandura's (1977, 1986) social learning theory, students tended to have role models whose race was the same as…

  16. What Is a PE Teacher's Role? The Influence of Learning Opportunities on Role Definition

    ERIC Educational Resources Information Center

    Keay, Jeanne K.

    2006-01-01

    At a time when the role of a physical education teacher in schools is being called into question, this article considers the relationship between learning opportunities and role definition. Previous research suggests that teachers define their roles through prior experience; through interaction with colleagues, friends, family and media; and in…

  17. Roles of sucrose in guard cell regulation.

    PubMed

    Daloso, Danilo M; Dos Anjos, Leticia; Fernie, Alisdair R

    2016-08-01

    The control of stomatal aperture involves reversible changes in the concentration of osmolytes in guard cells. Sucrose has long been proposed to have an osmolytic role in guard cells. However, direct evidence for such a role is lacking. Furthermore, recent evidence suggests that sucrose may perform additional roles in guard cells. Here, we provide an update covering the multiple roles of sucrose in guard cell regulation, highlighting the knowledge accumulated regarding spatiotemporal differences in the synthesis, accumulation, and degradation of sucrose as well as reviewing the role of sucrose as a metabolic connector between mesophyll and guard cells. Analysis of transcriptomic data from previous studies reveals that several genes encoding sucrose and hexose transporters and genes involved in gluconeogenesis, sucrose and trehalose metabolism are highly expressed in guard cells compared with mesophyll cells. Interestingly, this analysis also showed that guard cells have considerably higher expression of C4 -marker genes than mesophyll cells. We discuss the possible roles of these genes in guard cell function and the role of sucrose in stomatal opening and closure. Finally, we provide a perspective for future experiments which are required to fill gaps in our understanding of both guard cell metabolism and stomatal regulation. PMID:27060199

  18. Aggression toward gay men as gender role enforcement: effects of male role norms, sexual prejudice, and masculine gender role stress.

    PubMed

    Parrott, Dominic J

    2009-08-01

    This study examined sexual prejudice and masculine gender role stress as mediators of the relations between male gender norms and anger and aggression toward gay men. Participants were 150 self-identified heterosexual men who completed measures of adherence to male gender role norms, sexual prejudice, masculine gender role stress, and state anger. Participants then viewed a video depicting intimate relationship behavior between 2 gay men, reported state anger a second time, and competed in a laboratory aggression task against either a heterosexual or a gay male. Results indicated that adherence to the antifemininity norm exerted an indirect effect, primarily through sexual prejudice, on increases in anger. Adherence to the status and antifemininity norms exerted indirect effects, also through sexual prejudice, on physical aggression toward the gay, but not the heterosexual, male. Findings provide the first multivariate evidence for determinants of aggression toward gay men motivated by gender role enforcement. PMID:19558440

  19. Aggression Toward Gay Men as Gender Role Enforcement: Effects of Male Role Norms, Sexual Prejudice, and Masculine Gender Role Stress

    PubMed Central

    Parrott, Dominic J.

    2009-01-01

    This study examined sexual prejudice and masculine gender role stress as mediators of the relations between male gender norms and anger and aggression toward gay men. Participants were 150 self-identified heterosexual men who completed measures of adherence to male gender role norms, sexual prejudice, masculine gender role stress, and state anger. Participants then viewed a video depicting intimate relationship behavior between two gay men, reported state anger a second time, and competed in a laboratory aggression task against either a heterosexual or a gay male. Results indicated that adherence to the antifemininity norm exerted an indirect effect, primarily through sexual prejudice, on increases in anger. Adherence to the status and antifemininity norms exerted indirect effects, also through sexual prejudice, on physical aggression toward the gay, but not the heterosexual, male. Findings provide the first multivariate evidence for determinants of aggression toward gay men motivated by gender role enforcement. PMID:19558440

  20. Mexican-American adolescents' gender role attitude development: the role of adolescents' gender and nativity and parents' gender role attitudes.

    PubMed

    Updegraff, Kimberly A; McHale, Susan M; Zeiders, Katharine H; Umaña-Taylor, Adriana J; Perez-Brena, Norma J; Wheeler, Lorey A; Rodríguez De Jesús, Sue A

    2014-12-01

    Gender development has long term implications for education and career endeavors and family formation behaviors, but we know very little about the role of sociocultural factors in developmental and individual differences. In this study, we investigated one domain of gender development, gender role attitudes, in Mexican-American adolescents (N = 246; 51 % female), using four phases of longitudinal data across 8 years. Data were collected when adolescents averaged 12.51 years (SD = 0.58), 14.64 years (SD = 0.59), 17.72 years (SD = 0.57), and 19.60 years of age (SD = 0.66). Mothers' and fathers' gender role attitudes also were assessed in Phases 1, 3, and 4. Findings revealed that gender attitude development varied as a function of the interaction between adolescents' nativity and gender. Among Mexico-born adolescents, females exhibited significant declines in traditional attitudes from early to late adolescence, but males' attitudes were stable over time. U.S.-born females and males, in contrast, did not differ in their gender attitude trajectories. Examining the links between mothers', fathers', and adolescents' gender role attitudes revealed within-person associations between mothers' and adolescents' gender role attitudes: on occasions when mothers reported more traditional attitudes relative to their own cross-time average, adolescents also reported more traditional attitudes than usual. In addition, fathers' more traditional gender role attitudes were associated with daughters', but not sons', more traditional gender role attitudes at the between-person level. The discussion focuses on the interpretation of Mexican-American adolescents' gender role attitude development from a cultural ecological perspective. PMID:24777649

  1. Mexican American Adolescents’ Gender Role Attitude Development: The Role of Adolescents’ Gender and Nativity and Parents’ Gender Role Attitudes

    PubMed Central

    Updegraff, Kimberly A.; McHale, Susan M.; Zeiders, Katharine H.; Umaña-Taylor, Adriana J.; Perez-Brena, Norma J.; Wheeler, Lorey A.; Rodríguez De Jesús, Sue A.

    2014-01-01

    Gender development has long term implications for education and career endeavors and family formation behaviors, but we know very little about the role of sociocultural factors in developmental and individual differences. In this study, we investigated one domain of gender development, gender role attitudes, in Mexican American adolescents (N = 246; 51% female), using four phases of longitudinal data across eight years. Data were collected when adolescents averaged 12.51 years (SD = 0.58), 14.64 years (SD = 0.59), 17.72 years (SD = 0.57), and 19.60 years of age (SD = 0.66). Mothers’ and fathers’ gender role attitudes also were assessed in Phases 1, 3, and 4. Findings revealed that gender attitude development varied as a function of the interaction between adolescents’ nativity and gender. Among Mexico-born adolescents, females exhibited significant declines in traditional attitudes from early to late adolescence, but males’ attitudes were stable over time. U.S.-born females and males, in contrast, did not differ in their gender attitude trajectories. Examining the links between mothers’, fathers’, and adolescents’ gender role attitudes revealed within-person associations between mothers’ and adolescents’ gender role attitudes: on occasions when mothers reported more traditional attitudes relative to their own cross-time average, adolescents also reported more traditional attitudes than usual. In addition, fathers’ more traditional gender role attitudes were associated with daughters’, but not sons’, more traditional gender role attitudes at the between-person level. The discussion focuses on the interpretation of Mexican American adolescents’ gender role attitude development from a cultural ecological perspective. PMID:24777649

  2. Role of Sodium Channels in Epilepsy.

    PubMed

    Kaplan, David I; Isom, Lori L; Petrou, Steven

    2016-01-01

    Voltage-gated sodium channels (VGSCs) are fundamentally important for the generation and coordinated transmission of action potentials throughout the nervous system. It is, therefore, unsurprising that they have been shown to play a central role in the genesis and alleviation of epilepsy. Genetic studies on patients with epilepsy have identified more than 700 mutations among the genes that encode for VGSCs attesting to their role in pathogenesis. Further, many common antiepileptic drugs act on VGSCs to suppress seizure activity. Here, we present an account of the role of VGSCs in epilepsy, both through their pathogenic dysfunction and as targets for pharmacotherapy. PMID:27143702

  3. Patient advocacy: the role of the nurse.

    PubMed

    Choi, Pin Pin

    2015-06-10

    The role of nurses as patient advocates is well recognised by healthcare professionals, yet the processes and practices involved in patient advocacy are not clearly understood. A suboptimal level of advocacy is often apparent in the literature, encompassing paternalistic concepts of protecting patients from harm. This article examines the concept of patient advocacy and its relevance to nursing, associated goals and outcomes of advocacy and the processes and practices involved. It provides insights into how nurses practise patient advocacy in healthcare settings and how they may develop this role further, through formal education, workplace learning, role modelling by expert nurses and promoting an organisational culture conducive to patient advocacy. PMID:26058653

  4. Working Sandwich Generation Women Utilize Strategies within and between Roles to Achieve Role Balance

    PubMed Central

    Girdler, Sonya J.

    2016-01-01

    Increasingly, women simultaneously balance the roles of mother, parental carer and worker. However, individual role balance strategies among these working ‘sandwich’ generation women have not been thoroughly explored. Eighteen women combining these three roles were interviewed about their individual role balance strategies. Findings were identified through the framework analysis technique, underpinned by the Model of Juggling Occupations. Achieving and maintaining role balance was explained as a complex process accomplished through a range of strategies. Findings revealed the women used six within-role balance strategies: living with integrity, being the best you can, doing what you love, loving what you do, remembering why and searching for signs of success. The women also described six between-role balance strategies: maintaining health and wellbeing, repressing perfectionism, managing time and energy, releasing responsibility, nurturing social connection and reciprocating. These findings provide a basis for health care providers to understand and potentially support working ‘sandwich’ generation women. PMID:27305074

  5. Working Sandwich Generation Women Utilize Strategies within and between Roles to Achieve Role Balance.

    PubMed

    Evans, Kiah L; Millsteed, Jeannine; Richmond, Janet E; Falkmer, Marita; Falkmer, Torbjorn; Girdler, Sonya J

    2016-01-01

    Increasingly, women simultaneously balance the roles of mother, parental carer and worker. However, individual role balance strategies among these working 'sandwich' generation women have not been thoroughly explored. Eighteen women combining these three roles were interviewed about their individual role balance strategies. Findings were identified through the framework analysis technique, underpinned by the Model of Juggling Occupations. Achieving and maintaining role balance was explained as a complex process accomplished through a range of strategies. Findings revealed the women used six within-role balance strategies: living with integrity, being the best you can, doing what you love, loving what you do, remembering why and searching for signs of success. The women also described six between-role balance strategies: maintaining health and wellbeing, repressing perfectionism, managing time and energy, releasing responsibility, nurturing social connection and reciprocating. These findings provide a basis for health care providers to understand and potentially support working 'sandwich' generation women. PMID:27305074

  6. Organizational role stress among medical school faculty members in Iran: dealing with role conflict

    PubMed Central

    Ahmady, Soleiman; Changiz, Tahereh; Masiello, Italo; Brommels, Mats

    2007-01-01

    Background Little research has been conducted to investigate role stress experienced by faculty members in medical schools in developing countries. This becomes even more important when the process of reform in medical education has already taken place, such as the case of Iran. The objectives of this study were to investigate and assess the level and source of role-related stress as well as dimensions of conflict among the faculty members of Iranian medical schools. Variables like the length of academic work, academic rank, employment position, and the departments of affiliation were also taken into consideration in order to determine potentially related factors. Methods A survey was conducted at three different ranks of public medical schools. The validated Organizational Role Stress Scale was used to investigate the level of role stress and dimensions of role conflict among medical faculty members. The response rate was 66.5%. Results The findings show that role stress was experienced in high level among almost all faculty members. All three studied medical schools with different ranks are threatened with relatively the same levels of role stress. Specific differences were found among faculty members from different disciplines, and academic ranks. Also having permanent position and the length of services had significant correlation with the level of role stress. The major role- related stress and forms of conflict among faculty members were role overload, role expectation conflict, inter-role distance, resource inadequacy, role stagnation, and role isolation. Conclusion The most role-related stressors and forms of conflict among faculty members include too many tasks and everyday work load; conflicting demands from colleagues and superiors; incompatible demands from their different personal and organizational roles; inadequate resources for appropriate performance; insufficient competency to meet the demands of their role; inadequate autonomy to make decision on

  7. Preserving Intellectual Freedom: The Principal's Role.

    ERIC Educational Resources Information Center

    Agee, Hugh

    1993-01-01

    Argues that one of the primary roles of any school principal is to act as champion of students' rights of academic and intellectual freedom. Provides five steps that principals can take to preserve intellectual freedom in their schools. (HB)

  8. Fish Peroxiredoxins and Their Role in Immunity

    PubMed Central

    Valero, Yulema; Martínez-Morcillo, Francisco J.; Esteban, M. Ángeles; Chaves-Pozo, Elena; Cuesta, Alberto

    2015-01-01

    Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The most studied roles of Prx1 and Prx2 are immunological. Here we present a review on the effects of some immunostimulant treatments and bacterial, viral, or parasitic infections on the expression of fish Prxs at the gene and/or protein level, and point to their important role in immunity. The Prxs show antioxidant activity as well as a protective effect against infection. Some preliminary data are presented about the role of fish Prx1 and Prx2 in virus resistance although further studies are needed before the role of fish Prx in immunity can be definitively defined. PMID:26633533

  9. Knowledge Management in Role Based Agents

    NASA Astrophysics Data System (ADS)

    Kır, Hüseyin; Ekinci, Erdem Eser; Dikenelli, Oguz

    In multi-agent system literature, the role concept is getting increasingly researched to provide an abstraction to scope beliefs, norms, goals of agents and to shape relationships of the agents in the organization. In this research, we propose a knowledgebase architecture to increase applicability of roles in MAS domain by drawing inspiration from the self concept in the role theory of sociology. The proposed knowledgebase architecture has granulated structure that is dynamically organized according to the agent's identification in a social environment. Thanks to this dynamic structure, agents are enabled to work on consistent knowledge in spite of inevitable conflicts between roles and the agent. The knowledgebase architecture is also implemented and incorporated into the SEAGENT multi-agent system development framework.

  10. The Role of Screen Translation: A Response.

    ERIC Educational Resources Information Center

    O'Connell, Eithne

    2000-01-01

    Discusses the role of screen translation in minority language broadcasting. The article is a response to a roundtable discussion on minority language broadcasting and language maintenance. (Author/VWL)

  11. Role Conflict and Ambiguity in Complex Organizations

    ERIC Educational Resources Information Center

    Rizzo, John R.; And Others

    1970-01-01

    Study describes the development and testing of questionnaire measures of role conflict and ambiguity. Analyses of responses of managers show these two constructs to be factorially identifiable and independent. (Author/KJ)

  12. Justice, citizenship, and role definition effects.

    PubMed

    Tepper, B J; Lockhart, D; Hoobler, J

    2001-08-01

    A limitation of the organizational citizenship behavior (OCB) literature is that theory and empirical evidence suggest that some employees define OCBs as part of their job. A theoretical framework that addresses this problem is tested in this article. The framework focuses on 2 effects: a role enlargement effect (i.e., employees with more favorable attitudes define OCB as inrole behavior, which, in turn, results in greater citizenship) and a role discretion effect (i.e., the relationship between employees' attitudes and their citizenship will be stronger among employees who define OCB as extrarole behavior). In tests of this framework with 2 independent samples of supervisor-subordinate dyads, role definitions were found to moderate several relationships between procedural justice and OCB, providing support for the role discretion effect. Implications for OCB theory and research are discussed. PMID:11519662

  13. Switching Roles: When Teachers Become Students

    ERIC Educational Resources Information Center

    Motz, Annabelle B.; Hollander, Elaine K.

    1973-01-01

    Impressions of what teachers experience when they are registered in a graduate level course as students and the ways in which they accommodate to their new role are analyzed by the research method of participation-observation. (Author/KM)

  14. Role of inflammation in the aging bones.

    PubMed

    Abdelmagid, Samir M; Barbe, Mary F; Safadi, Fayez F

    2015-02-15

    Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to inherent changes in mesenchymal stem cell (MSC) differentiation, resulting in impaired osteoblastogenesis. Also, the pro-inflammatory cytokines increase with aging, leading to enhanced myelopoiesis and osteoclastogenesis. Bone marrow macrophages (BMMs) play pivotal roles in osteoblast differentiation, the maintenance of hematopoietic stem cells (HSCs), and subsequent bone repair. However, during aging, little is known about the role of macrophages in the differentiation and function of MSC and HSC. Aged mammals have higher circulating pro-inflammatory cytokines than young adults, supporting the hypothesis of increased inflammation with aging. This review will aid in the understanding of the potential role(s) of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in differentiation and function of osteoblasts and osteoclasts in relation to aging. PMID:25510309

  15. Role of laparoscopy in hepatobiliary malignancies.

    PubMed

    Arumugam, Prabhu; Balarajah, Vickna; Watt, Jennifer; Abraham, Ajit T; Bhattacharya, Satyajit; Kocher, Hemant M

    2016-04-01

    The many benefits of laparoscopy, including smaller incision, reduced length of hospital stay and more rapid return to normal function, have seen its popularity grow in recent years. With concurrent improvements in non-surgical cancer management the importance of accurate staging is becoming increasingly important. There are two main applications of laparoscopic surgery in managing hepato-pancreatico-biliary (HPB) malignancy: accurate staging of disease and resection. We aim to summarize the use of laparoscopy in these contexts. The role of staging laparoscopy has become routine in certain cancers, in particular T[2] staged, locally advanced gastric cancer, hilar cholangiocarcinoma and non-Hodgkin's lymphoma. For other cancers, in particular colorectal, laparoscopy has now become the gold standard management for resection such that there is no role for stand-alone staging laparoscopy. In HPB cancers, although staging laparoscopy may play a role, with ever improving radiology, its role remains controversial. PMID:27377496

  16. The role of the food industry.

    PubMed

    Mettler, A E

    1986-01-01

    The role of the manufacturing food industry in relation to provision of foods for the weanling encompasses 4 main objectives viz. customer satisfaction, safety, providing product information and the maintenance of commercial viability. The effectiveness of the manufacturing food industry to fulfil these roles is judged by the customer wishing to buy for quality and convenience reasons, by the law of the land in meeting legal requirements for safety and labelling and by its generation of profit in terms of commercial viability. Whereas it is commonly expected that industry should fulfil a role in nutrition education this is seen as a primary role of health professionals whilst industry needs to provide full and detailed product information. The industry is highly creative in both its technological innovation and adaptation and works hard at trying to satisfy the requirements of consumers, the industry, health professionals and its critics. PMID:3463120

  17. Role of laparoscopy in hepatobiliary malignancies

    PubMed Central

    Arumugam, Prabhu; Balarajah, Vickna; Watt, Jennifer; Abraham, Ajit T.; Bhattacharya, Satyajit; Kocher, Hemant M.

    2016-01-01

    The many benefits of laparoscopy, including smaller incision, reduced length of hospital stay and more rapid return to normal function, have seen its popularity grow in recent years. With concurrent improvements in non-surgical cancer management the importance of accurate staging is becoming increasingly important. There are two main applications of laparoscopic surgery in managing hepato-pancreatico-biliary (HPB) malignancy: accurate staging of disease and resection. We aim to summarize the use of laparoscopy in these contexts. The role of staging laparoscopy has become routine in certain cancers, in particular T2 staged, locally advanced gastric cancer, hilar cholangiocarcinoma and non-Hodgkin's lymphoma. For other cancers, in particular colorectal, laparoscopy has now become the gold standard management for resection such that there is no role for stand-alone staging laparoscopy. In HPB cancers, although staging laparoscopy may play a role, with ever improving radiology, its role remains controversial. PMID:27377496

  18. Exploring the role of modern day fatherhood.

    PubMed

    Hermansen, Spencer; Croninger, Bill; Croninger, Sara

    2015-01-01

    The case is the personal perspective and reflection of a father and his daughter, each individually addressing five key aspects of the role of father, revealing a unique and fundamental family perspective. PMID:25248532

  19. The Role of Social Isolation in Suicide.

    ERIC Educational Resources Information Center

    Trout, Deborah L.

    1980-01-01

    Reviews the literature which relates to the role of social isolation in suicide. Major areas reviewed include theories on suicide and social isolation, measures of social isolation, and empirical studies which concern the relationship of social isolation to suicide. (Author)

  20. Roles of Galectin-7 in Cancer.

    PubMed

    Kaur, Manpreet; Kaur, Tarnjeet; Kamboj, Sukhdev Singh; Singh, Jatinder

    2016-01-01

    Galectins are β-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers. PMID:26925627

  1. Role of succinic acid in chemical evolution

    NASA Technical Reports Server (NTRS)

    Negron-Mendoza, A.; Ponnamperuma, C.

    1982-01-01

    Succinic acid is converted into other carboxylic acids by ionizing radiation. The results obtained have been correlated with the ready formation of this compound in prebiotic experiments. Its role in biological systems may be related to its prebiotic occurrence.

  2. The Future Roles of the Rehabilitation Counselor

    ERIC Educational Resources Information Center

    Muthard, John E.; Salomone, Paul R.

    1972-01-01

    The expectations of 50 rehabilitation leaders for the role and responsibilities of rehabilitation counselors in 1980 are summarized. Their projections, made in 1967, include the types of tasks, settings, clients, and services rehabilitation counselors will experience. (Author)

  3. NASA's Role in Understanding Climate Change

    NASA Video Gallery

    Earth's climate is changing because of human activity. Learn about NASA's role in understanding climate and climate change with Gilberto Colón, special assistant to the deputy director of NASA's Go...

  4. Planning and Role Setting: Alone or Together?

    ERIC Educational Resources Information Center

    Richmond, Elizabeth

    1988-01-01

    Reviews the recent American Library Association publication, "Planning and Role Setting for Public Libraries: A Manual of Options and Procedures," noting omissions in its approach. Several reasons for including the larger library community in the planning process are discussed. (MES)

  5. Role of neutrophils in systemic autoimmune diseases

    PubMed Central

    2013-01-01

    Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles that neutrophils and aberrant neutrophil cell death play in the pathogenesis of various systemic autoimmune diseases, including systemic lupus erythematosus, small vessel vasculitis and rheumatoid arthritis. PMID:24286137

  6. The role of inhibition in epileptic networks.

    PubMed

    Trevelyan, Andrew J; Muldoon, Sarah F; Merricks, Edward M; Racca, Claudia; Staley, Kevin J

    2015-06-01

    Inhibition plays many roles in cortical circuits, including coordination of network activity in different brain rhythms and neuronal clusters, gating of activity, gain control, and dictating the manner in which activity flows through the network. This latter is particularly relevant to epileptic states, when extreme hypersynchronous discharges can spread across cortical territories. We review these different physiological and pathological roles and discuss how inhibition can be compromised and why this predisposes the network to seizures. PMID:26035675

  7. Role Models for Pregnancy, Birth, and Breastfeeding

    PubMed Central

    Budin, Wendy C.

    2011-01-01

    In this column, the editor of The Journal of Perinatal Education discusses how the media provide role models—good and bad—for pregnancy, birth, and breastfeeding. There is a critical need for more positive role models that promote natural, safe, and healthy pregnancy and birth. The editor also describes the contents of this issue, which offer a broad range of resources, research, and inspiration for childbirth educators in their efforts to promote natural, safe, and healthy birth. PMID:22379353

  8. Role of vitamins in gastrointestinal diseases

    PubMed Central

    Masri, Omar A; Chalhoub, Jean M; Sharara, Ala I

    2015-01-01

    A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases. For instance, most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials, however interventional trials failed to prove a clear beneficial preventive role. On the other hand, more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities. Examples for this include the therapeutic role of vitamin E in patients with non-alcoholic steatohepatitis, the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus, the role of vitamin C in reducing the risk of gallstones, the positive outcome with vitamin B12 in patients with aphthous stomatitis, and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease. Other potential uses are yet to be elaborated, like those on celiac disease, pancreatic cancer, pancreatitis, cholestasis and other potential fields. Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years. Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost, their use should be encouraged in the fields where positive data are available. PMID:25954093

  9. Roles of social impact assessment practitioners

    SciTech Connect

    Wong, Cecilia H.M. Ho, Wing-chung

    2015-01-15

    The effectiveness of social impact assessment (SIA) hinges largely on the capabilities and ethics of the practitioners, yet few studies have dedicated to discuss the expectations for these professionals. Recognising this knowledge gap, we employed the systemic review approach to construct a framework of roles of SIA practitioners from literature. Our conceptual framework encompasses eleven roles, namely project manager of SIA, practitioner of SIA methodologies, social researcher, social strategy developer, social impact management consultant, community developer, visionary, public involvement specialist, coordinator, SIA researcher, and educator. Although these roles have been stratified into three overarching categories, the project, community and SIA development, they are indeed interrelated and should be examined together. The significance of this study is threefold. First, it pioneers the study of the roles of SIA practitioners in a focused and systematic manner. Second, it informs practitioners of the expectations of them thereby fostering professionalism. Third, it prepares the public for SIAs by elucidating the functions and values of the assessment. - Highlights: • We adopt systematic review to construct a framework of roles of social impact assessment (SIA) practitioners from literature. • We use three overarching categorises to stratify the eleven roles we proposed. • This work is a novel attempt to study the work as a SIA practitioner and build a foundation for further exploration. • The framework informs practitioners of the expectations on them thus reinforcing professionalism. • The framework also prepares the public for SIAs by elucidating the functions and values of the assessment.

  10. Evidence for the social role theory of stereotype content: observations of groups' roles shape stereotypes.

    PubMed

    Koenig, Anne M; Eagly, Alice H

    2014-09-01

    In applying social role theory to account for the content of a wide range of stereotypes, this research tests the proposition that observations of groups' roles determine stereotype content (Eagly & Wood, 2012). In a novel test of how stereotypes can develop from observations, preliminary research collected participants' beliefs about the occupational roles (e.g., lawyer, teacher, fast food worker, chief executive officer, store clerk, manager) in which members of social groups (e.g., Black women, Hispanics, White men, the rich, senior citizens, high school dropouts) are overrepresented relative to their numbers in the general population. These beliefs about groups' typical occupational roles proved to be generally accurate when evaluated in relation to data from the Bureau of Labor Statistics. Then, correlational studies predicted participants' stereotypes of social groups from the attributes ascribed to group members' typical occupational roles (Studies 1a, 1b, and 1c), the behaviors associated with those roles (Study 2), and the occupational interest profile of the roles (Study 3). As predicted by social role theory, beliefs about the attributes of groups' typical roles were strongly related to group stereotypes on both communion and agency/competence. In addition, an experimental study (Study 4) demonstrated that when social groups were described with changes to their typical social roles in the future, their projected stereotypes were more influenced by these future roles than by their current group stereotypes, thus supporting social role theory's predictions about stereotype change. Discussion considers the implications of these findings for stereotype change and the relation of social role theory to other theories of stereotype content. PMID:25133722

  11. Multifaceted Role of Sialylation in Prion Diseases

    PubMed Central

    Baskakov, Ilia V.; Katorcha, Elizaveta

    2016-01-01

    Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein, or PrPC. Sialylation of the prion protein N-linked glycans was discovered more than 30 years ago, yet the role of sialylation in prion pathogenesis remains poorly understood. Recent years have witnessed extraordinary growth in interest in sialylation and established a critical role for sialic acids in host invasion and host-pathogen interactions. This review article summarizes current knowledge on the role of sialylation of the prion protein in prion diseases. First, we discuss the correlation between sialylation of PrPSc glycans and prion infectivity and describe the factors that control sialylation of PrPSc. Second, we explain how glycan sialylation contributes to the prion replication barrier, defines strain-specific glycoform ratios, and imposes constraints for PrPSc structure. Third, several topics, including a possible role for sialylation in animal-to-human prion transmission, prion lymphotropism, toxicity, strain interference, and normal function of PrPC, are critically reviewed. Finally, a metabolic hypothesis on the role of sialylation in the etiology of sporadic prion diseases is proposed. PMID:27551257

  12. Bitter taste receptors: Extraoral roles in pathophysiology.

    PubMed

    Shaik, Feroz Ahmed; Singh, Nisha; Arakawa, Makoto; Duan, Kangmin; Bhullar, Rajinder P; Chelikani, Prashen

    2016-08-01

    Over the past decade tremendous progress has been made in understanding the functional role of bitter taste receptors (T2Rs) and bitter taste perception. This review will cover the recent advances made in identifying the role of T2Rs in pathophysiological states. T2Rs are widely expressed in various parts of human anatomy and have been shown to be involved in physiology of respiratory system, gastrointestinal tract and endocrine system. Empirical evidence has shown T2Rs to be an integral component of antimicrobial immune responses in upper respiratory tract infections. The studies on human airway smooth muscle cells have shown that a potent bitter tastant induced bronchodilatory effects mediated by bitter taste receptors. Clinical data suggests a role for T2R38 polymorphism in predisposition of individuals to chronic rhinosinusitis. The role of genetic variation in T2Rs and its impact on disease susceptibility have been investigated in various other disease risk factors such as alcohol dependence, head and neck cancers. Preliminary reports have demonstrated differential expression of functional T2Rs in breast cancer cell lines. Studies on the role of T2Rs in pathophysiology of diseases including chronic rhinosinusitis, asthma, cystic fibrosis, and cancer have been promising. However, research in this field is in its nascent stages, and more confirmatory studies on animal models and in clinical settings are required. PMID:27032752

  13. Multifaceted Role of Sialylation in Prion Diseases.

    PubMed

    Baskakov, Ilia V; Katorcha, Elizaveta

    2016-01-01

    Mammalian prion or PrP(Sc) is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein, or PrP(C). Sialylation of the prion protein N-linked glycans was discovered more than 30 years ago, yet the role of sialylation in prion pathogenesis remains poorly understood. Recent years have witnessed extraordinary growth in interest in sialylation and established a critical role for sialic acids in host invasion and host-pathogen interactions. This review article summarizes current knowledge on the role of sialylation of the prion protein in prion diseases. First, we discuss the correlation between sialylation of PrP(Sc) glycans and prion infectivity and describe the factors that control sialylation of PrP(Sc). Second, we explain how glycan sialylation contributes to the prion replication barrier, defines strain-specific glycoform ratios, and imposes constraints for PrP(Sc) structure. Third, several topics, including a possible role for sialylation in animal-to-human prion transmission, prion lymphotropism, toxicity, strain interference, and normal function of PrP(C), are critically reviewed. Finally, a metabolic hypothesis on the role of sialylation in the etiology of sporadic prion diseases is proposed. PMID:27551257

  14. Antagonistic neural networks underlying differentiated leadership roles

    PubMed Central

    Boyatzis, Richard E.; Rochford, Kylie; Jack, Anthony I.

    2014-01-01

    The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950s. Recent research in neuroscience suggests that the division between task-oriented and socio-emotional-oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks – the task-positive network (TPN) and the default mode network (DMN). Neural activity in TPN tends to inhibit activity in the DMN, and vice versa. The TPN is important for problem solving, focusing of attention, making decisions, and control of action. The DMN plays a central role in emotional self-awareness, social cognition, and ethical decision making. It is also strongly linked to creativity and openness to new ideas. Because activation of the TPN tends to suppress activity in the DMN, an over-emphasis on task-oriented leadership may prove deleterious to social and emotional aspects of leadership. Similarly, an overemphasis on the DMN would result in difficulty focusing attention, making decisions, and solving known problems. In this paper, we will review major streams of theory and research on leadership roles in the context of recent findings from neuroscience and psychology. We conclude by suggesting that emerging research challenges the assumption that role differentiation is both natural and necessary, in particular when openness to new ideas, people, emotions, and ethical concerns are important to success. PMID:24624074

  15. Role of Osteopontin in Liver Diseases

    PubMed Central

    Wen, Yankai; Jeong, Seogsong; Xia, Qiang; Kong, Xiaoni

    2016-01-01

    Osteopontin (OPN), a multifunctional protein, is involved in numerous pathological conditions including inflammation, immunity, angiogenesis, fibrogenesis and carcinogenesis in various tissues. Extensive studies have elucidated the critical role of OPN in cell signaling such as regulation of cell proliferation, migration, inflammation, fibrosis and tumor progression. In the liver, OPN interacts with integrins, CD44, vimentin and MyD88 signaling, thereby induces infiltration, migration, invasion and metastasis of cells. OPN is highlighted as a chemoattractant for macrophages and neutrophils during injury in inflammatory liver diseases. OPN activates hepatic stellate cells (HSCs) to exert an enhancer in fibrogenesis. The role of OPN in hepatocellular carcinoma (HCC) has also generated significant interests, especially with regards to its role as a diagnostic and prognostic factor. Interestingly, OPN acts an opposing role in liver repair under different pathological conditions. This review summarizes the current understanding of OPN in liver diseases. Further understanding of the pathophysiological role of OPN in cellular interactions and molecular mechanisms associated with hepatic inflammation, fibrosis and cancer may contribute to the development of novel strategies for clinical diagnosis, monitoring and therapy of liver diseases. PMID:27570486

  16. Antagonistic neural networks underlying differentiated leadership roles.

    PubMed

    Boyatzis, Richard E; Rochford, Kylie; Jack, Anthony I

    2014-01-01

    The emergence of two distinct leadership roles, the task leader and the socio-emotional leader, has been documented in the leadership literature since the 1950s. Recent research in neuroscience suggests that the division between task-oriented and socio-emotional-oriented roles derives from a fundamental feature of our neurobiology: an antagonistic relationship between two large-scale cortical networks - the task-positive network (TPN) and the default mode network (DMN). Neural activity in TPN tends to inhibit activity in the DMN, and vice versa. The TPN is important for problem solving, focusing of attention, making decisions, and control of action. The DMN plays a central role in emotional self-awareness, social cognition, and ethical decision making. It is also strongly linked to creativity and openness to new ideas. Because activation of the TPN tends to suppress activity in the DMN, an over-emphasis on task-oriented leadership may prove deleterious to social and emotional aspects of leadership. Similarly, an overemphasis on the DMN would result in difficulty focusing attention, making decisions, and solving known problems. In this paper, we will review major streams of theory and research on leadership roles in the context of recent findings from neuroscience and psychology. We conclude by suggesting that emerging research challenges the assumption that role differentiation is both natural and necessary, in particular when openness to new ideas, people, emotions, and ethical concerns are important to success. PMID:24624074

  17. Perceived Role-Taking Behavior and Role-Taking Test Performance in Fraternity and Sorority College Students.

    ERIC Educational Resources Information Center

    Moser, Rosemarie Scolaro

    Generally, role-taking research has focused on the development and correlates of role taking in children. To explore role taking in the relatively overlooked population of young adults, a sociometric instrument, the Peer Role-Taking Questionnaire (PRTQ), was developed and used to measure perceived role-taking behaviors. The results were compared…

  18. Climate hazards, adaptation and "resilience" of societies (early Little Ice Age, west of France).

    NASA Astrophysics Data System (ADS)

    Athimon, Emmanuelle; Maanan, Mohamed

    2016-04-01

    exports of wine or salt to finance the restoration of the bridges. So it appears that these societies have been able to adapt through a collective memory, a lifestyle, a significant perception of risks, a territory management, the construction of infrastructures, etc. Key words : Little Ice Age, West of France, climate hazards, resilience, adaptation. This work was supported by grants from the Fondation de France through the research program « Quels littoraux pour demain? ».

  19. Teams without Roles: Empowering Teams for Greater Creativity.

    ERIC Educational Resources Information Center

    McCrimmon, Mitch

    1995-01-01

    Criticizes Belbin's team role theory on the basis that roles are appropriate only in static organizations. Argues that most teams have no set roles and members interchange them. Suggests that all team members be trained to manage teamwork effectively. (SK)

  20. The role of Probiotics in allergic diseases

    PubMed Central

    Michail, Sonia

    2009-01-01

    Allergic disorders are very common in the pediatric age group. While the exact etiology is unclear, evidence is mounting to incriminate environmental factors and an aberrant gut microbiota with a shift of the Th1/Th2 balance towards a Th2 response. Probiotics have been shown to modulate the immune system back to a Th1 response. Several in vitro studies suggest a role for probiotics in treating allergic disorders. Human trials demonstrate a limited benefit for the use of probiotics in atopic dermatitis in a preventive as well as a therapeutic capacity. Data supporting their use in allergic rhinitis are less robust. Currently, there is no role for probiotic therapy in the treatment of bronchial asthma. Future studies will be critical in determining the exact role of probiotics in allergic disorders. PMID:19946408

  1. Role of STAT3 in lung cancer

    PubMed Central

    Dutta, Pranabananda; Sabri, Nafiseh; Li, Jinghong; Li, Willis X

    2014-01-01

    Lung cancer remains a challenging disease. It is responsible for the high cancer mortality rates in the US and worldwide. Elucidation of the molecular mechanisms operative in lung cancer is an important first step in developing effective therapies. Accumulating evidence over the last 2 decades suggests a critical role for Signal Transducer and Activator of Transcription 3 (STAT3) as a point of convergence for various signaling pathways that are dysregulated in the disease. In this review, we discuss possible molecular mechanisms involving STAT3 in lung tumorigenesis based on recent literature. We consider possible roles of STAT3 in cancer cell proliferation and survival, in the tumor immune environment, and in epigenetic regulation and interaction of STAT3 with other transcription factors. We also discuss the potential role of STAT3 in tumor suppression, which complicates strategies of targeting STAT3 in cancer therapy. PMID:26413424

  2. Cardiac arrhythmias in space. Role of vagotonia.

    PubMed

    Leguay, G; Seigneuric, A

    1981-07-01

    Rhythm disorders observed in space have always been minor but they are not unfrequent. They include: ventricular or supra-ventricular extrasystoles, nodal arrhythmias, auriculo-ventricular conduction disorders. There are several etiopathogenetic hypotheses: a strict selection must permit its elimination of an underlying heart disease; the potassium deficiency is often advanced but its role is not certain; the role of catecholamines is also discussed; the role of hypervagotony is extensively analysed as great clinical and electro-cardiographic evidence speaks for it. It can induce disorders which are more serious than those observed so far, particularly fibrillation or intermittent atrial flutter; weightlessness itself could partly condition the vagotonic state; and the effects of fluid shifts are also discussed from this point of view. The possible therapies for various atrial, nodal, ventricular disorders are reviewed, with greater detail for vagal atrial arrhythmias. PMID:11542963

  3. Neuropilins: expression and roles in the epithelium.

    PubMed

    Wild, Jonathan R L; Staton, Carolyn A; Chapple, Keith; Corfe, Bernard M

    2012-04-01

    Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in epithelial cells has received little attention when compared with neuronal and endothelial cells. Overexpression of NRPs is shown to enhance growth, correlate with invasion and is associated with poor prognosis in various tumour types, especially those of epithelial origin. The contribution of NRP and its ligands to tumour growth and metastasis has spurred a strong interest in NRPs as novel chemotherapy drug targets. Given NRP's role as a multifunctional co-receptor with an ability to bind with disparate ligand families, this has sparked new areas of research implicating NRPs in diverse biological functions. Here, we review the growing body of research demonstrating NRP expression and role in the normal and neoplastic epithelium. PMID:22414290

  4. Role of copper transporters in platinum resistance

    PubMed Central

    Kilari, Deepak; Guancial, Elizabeth; Kim, Eric S

    2016-01-01

    Platinum (Pt)-based antitumor agents are effective in the treatment of many solid malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced intracellular Pt accumulation has been consistently shown to correlate with resistance in tumors. Proteins involved in copper homeostasis have been identified as Pt transporters. In particular, copper transporter receptor 1 (CTR1), the major copper influx transporter, has been shown to play a significant role in Pt resistance. Clinical studies demonstrated that expression of CTR1 correlated with intratumoral Pt concentration and outcomes following Pt-based therapy. Other CTRs such as CTR2, ATP7A and ATP7B, may also play a role in Pt resistance. Recent clinical studies attempting to modulate CTR1 to overcome Pt resistance may provide novel strategies. This review discusses the role of CTR1 as a potential predictive biomarker of Pt sensitivity and a therapeutic target for overcoming Pt resistance. PMID:26862494

  5. Alcoholic Liver Disease: Role of Cytokines

    PubMed Central

    Neuman, Manuela G.; Maor, Yaakov; Nanau, Radu M.; Melzer, Ehud; Mell, Haim; Opris, Mihai; Cohen, Lawrence; Malnick, Stephen

    2015-01-01

    The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed. PMID:26343741

  6. Role of platelets in allergic airway inflammation.

    PubMed

    Idzko, Marco; Pitchford, Simon; Page, Clive

    2015-06-01

    Increasing evidence suggests an important role for platelets and their products (e.g., platelet factor 4, β-thromboglobulin, RANTES, thromboxane, or serotonin) in the pathogenesis of allergic diseases. A variety of changes in platelet function have been observed in patients with asthma, such as alterations in platelet secretion, expression of surface molecules, aggregation, and adhesion. Moreover, platelets have been found to actively contribute to most of the characteristic features of asthma, including bronchial hyperresponsiveness, bronchoconstriction, airway inflammation, and airway remodeling. This review brings together the current available data from both experimental and clinical studies that have investigated the role of platelets in allergic airway inflammation and asthma. It is anticipated that a better understanding of the role of platelets in the pathogenesis of asthma might lead to novel promising therapeutic approaches in the treatment of allergic airway diseases. PMID:26051948

  7. The role of macrophages in bone metastasis

    PubMed Central

    Vasiliadou, Ifigenia; Holen, Ingunn

    2013-01-01

    The skeleton is one of the most common sites of metastatic disease, affecting a large number of patients with advanced cancer. Although an increasing number of therapies are available for treatment of bone metastasis, this remains incurable, highlighting the need for better understanding of the underlying biology. Metastatic tumour spread to distant organs is a multistage process, involving not only cancer cells but also those of the surrounding host microenvironment. Tumour associated macrophages are multifunctional cells that contribute both to tumour development and response to treatment by regulating adaptive immunity, remodelling of stroma, mediating basement membrane breakdown and angiogenesis. Although direct evidence for a specific role of macrophages in bone metastasis is limited, their involvement in metastasis in general is well documented. In this review we provide an overview of role of macrophages in tumour progression, with particular emphasis on their potential role in bone metastasis. PMID:26909287

  8. Role of dental expert in forensic odontology.

    PubMed

    Verma, Anoop K; Kumar, Sachil; Rathore, Shiuli; Pandey, Abhishek

    2014-01-01

    Forensic dentistry has become an integral part of forensic science over the past 100 years that utilizes dental or oro-facial findings to serve the judicial system. This has been due to the dedication of people like Gustafson's, Keiser-Nielson, and Suzuki for this field. They established the essential role which forensic dentistry plays mainly in the identification of human remains. The tooth has been used as weapons and under certain circumstances, may leave information about the identity of the biter. Dental professionals have a major role to play in keeping accurate dental records and providing all necessary information so that legal authorities may recognize mal practice, negligence, fraud or abuse, and identity of unknown individuals. This paper will try to summarize the various roles of dental experts in forensic medicine. PMID:25298709

  9. Role of forensic pathologists in mass disasters.

    PubMed

    Schuliar, Yves; Knudsen, Peter Juel Thiis

    2012-06-01

    The forensic pathologist has always had a central role in the identification of the dead in every day practice, in accidents, and in disasters involving hundreds or thousands of victims. This role has changed in recent years, as advances in forensic odontology, genetics and anthropology have improved the chances of identifying victims beyond recognition. According to the Interpol DVI Guide, fingerprints, dental examination and DNA are the primary identifiers, and this has given new emphasis to the role of the forensic pathologist as the leader of a multidisciplinary team of experts in a disaster situation, based on his or her qualifications and the experience gained from doing the same work in the everyday situation of an institute of forensic medicine. PMID:22160735

  10. The veterinary technician's role in laser surgery.

    PubMed

    Kronberger, Charly

    2002-05-01

    The use of surgical lasers in veterinary practice has grown significantly since 1996. Many veterinarians have studied and implemented the basic physics and tissue didactics required to successfully incorporate a surgical laser program into their practice. The support role of the veterinary technician is crucial to ensuring an efficient, safe, and successful outcome of any surgical laser procedure. The technician's role may include practice management duties, client communication, and laser safety officer duties. Although there are a variety of lasers, the most common types used in veterinary practice are carbon dioxide (CO2) and diode. This article presents an overview of the veterinary technician's role as a key support person in ensuring a safe and positive outcome in the implementation of CO2 and diode lasers in a veterinary practice. PMID:12064050

  11. Oncogenic role of nucleophosmin/B23.

    PubMed

    Yung, Benjamin Yat Ming

    2007-01-01

    Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis. PMID:17939258

  12. Psychology's role in mathematics and science education.

    PubMed

    Newcombe, Nora S; Ambady, Nalini; Eccles, Jacquelynne; Gomez, Louis; Klahr, David; Linn, Marcia; Miller, Kevin; Mix, Kelly

    2009-09-01

    Improving mathematics and science education in the United States has been a matter of national concern for over half a century. Psychology has a vital role to play in this enterprise. In this article, the authors review the kinds of contributions that psychology can make in four areas: (a) early understanding of mathematics, (b) understanding of science, (c) social and motivational aspects of involvement in mathematics and science, and (d) assessment of learning in mathematics and science. They also examine challenges to psychology's playing a central and constructive role and make recommendations for overcoming those challenges. PMID:19739883

  13. Interleukin-33: increasing role in dermatological conditions.

    PubMed

    Balato, Anna; Raimondo, Annunziata; Balato, Nicola; Ayala, Fabio; Lembo, Serena

    2016-07-01

    Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings. PMID:26969580

  14. Role of Uncoupling Proteins in Cancer

    PubMed Central

    Valle, Adamo; Oliver, Jordi; Roca, Pilar

    2010-01-01

    Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance. PMID:24281083

  15. Diverse Roles of Prostaglandins in Blastocyst Implantation

    PubMed Central

    2014-01-01

    Prostaglandins (PGs), derivatives of arachidonic acid, play an indispensable role in embryo implantation. PGs have been reported to participate in the increase in vascular permeability, stromal decidualization, blastocyst growth and development, leukocyte recruitment, embryo transport, trophoblast invasion, and extracellular matrix remodeling during implantation. Deranged PGs syntheses and actions will result in implantation failure. This review summarizes up-to-date literatures on the role of PGs in blastocyst implantation which could provide a broad perspective to guide further research in this field. PMID:24616654

  16. Roles of FGFR in oral carcinogenesis.

    PubMed

    Xie, Xiaoyan; Wang, Zhiyong; Chen, Fangman; Yuan, Yao; Wang, Jiayi; Liu, Rui; Chen, Qianming

    2016-06-01

    Fibroblast growth factor receptors (FGFRs) play essential roles in organ development during the embryonic period, and regulate tissue repair in adults. Accumulating evidence suggests that alterations in FGFR signalling are involved in diverse types of cancer. In this review, we focus on aberrant regulation of FGFRs in pathogenesis of oral squamous cell carcinoma (OSCC), including altered expression and subcellular location, aberrant isoform splicing and mutations. We also provide an overview of oncogenic roles of each FGFR and its downstream signalling pathways in regulating OSCC cell proliferation and metastasis. Finally, we discuss potential application of FGFRs as anti-cancer targets in the preclinical environment and in clinical practice. PMID:27218663

  17. The Role of Stroma in Tumor Development

    PubMed Central

    Werb, Zena; Lu, Pengfei

    2016-01-01

    The tumor microenvironment plays an essential role in various stages of cancer development. This environment, composed of the extracellular matrix, fibroblasts, endothelial cells, and cells of the immune system regulates the behavior of and co-evolve with tumor cells. Many of the components, including the innate and adaptive immune cells, play multifaceted roles during cancer progression and can promote or inhibit tumor development, depending on local and systemic conditions. Interestingly, a strategy by which tumor cells gain drug resistance is by modifying the tumor microenvironment. Together, understanding the mechanisms by which the tumor microenvironment functions should greatly facilitate the development of new therapeutic interventions by targeting the tumor niche. PMID:26222075

  18. Male fertility: a possible role of vitamins.

    PubMed

    Kodentsova, V M; Vrzesinskaya, O A; Spirichev, V B

    1994-01-01

    This review concerns recent experimental information on some aspects revealing biochemical nature of the origin of defects responsible for the spermatozoa's loss of fertilizing potential. Possible protective effect of vitamins-antioxidants against peroxidative damage of spermatozoa playing a key role in the etiology of defective sperm function, regulating role of vitamins K and D in MM-isozyme creatine kinase activity serving as a measure of sperm biochemical maturity and normal sperm development and influence of body insufficiency of B group vitamins on energy metabolism disturbances in motile, actively metabolizing spermatozoa have been discussed. PMID:7747339

  19. Role of gravity in preparative electrophoresis

    NASA Technical Reports Server (NTRS)

    Bier, M.; Hinckley, J. O. N.; Smolka, A. J. K.; Binder, M. J.; Coxon, M.; Nee, T. W.; Scully, M. O.; Shih, H. S. T.; Snyder, R. S.

    1974-01-01

    Electrophoresis has contributed significantly to the methodology of biological sciences, and shows the potential for large scale fractionation of a wide range of medically important substances, including living cells. Gravity plays an important role in the electrophoretic process, and hence the importance of the NASA effort to develop a zero-gravity separation facility as part of its shuttle program. The current state of art in electrophoresis is reviewed with particular emphasis on the role of gravity and the possible use of istachophoresis. This technique utilizes a discontinuous buffer system, and appears to be the only high resolution electrophoretic technique currently available for separation of living cells.

  20. The Role of Autophagy in Hepatocellular Carcinoma

    PubMed Central

    Lee, Yoo Jin; Jang, Byoung Kuk

    2015-01-01

    Autophagy is a catabolic process involved in cellular homeostasis under basal and stressed conditions. Autophagy is crucial for normal liver physiology and the pathogenesis of liver diseases. During the last decade, the function of autophagy in hepatocellular carcinoma (HCC) has been evaluated extensively. Currently, autophagy is thought to play a dual role in HCC, i.e., autophagy is involved in tumorigenesis and tumor suppression. Recent investigations of autophagy have suggested that autophagy biomarkers can facilitate HCC prognosis and the establishment of therapeutic approaches. In this review, we briefly summarize the current understanding of autophagy and discuss recent evidence for its role in HCC. PMID:26561802

  1. The Role of Autophagy in Hepatocellular Carcinoma.

    PubMed

    Lee, Yoo Jin; Jang, Byoung Kuk

    2015-01-01

    Autophagy is a catabolic process involved in cellular homeostasis under basal and stressed conditions. Autophagy is crucial for normal liver physiology and the pathogenesis of liver diseases. During the last decade, the function of autophagy in hepatocellular carcinoma (HCC) has been evaluated extensively. Currently, autophagy is thought to play a dual role in HCC, i.e., autophagy is involved in tumorigenesis and tumor suppression. Recent investigations of autophagy have suggested that autophagy biomarkers can facilitate HCC prognosis and the establishment of therapeutic approaches. In this review, we briefly summarize the current understanding of autophagy and discuss recent evidence for its role in HCC. PMID:26561802

  2. Role of third molars in orthodontics.

    PubMed

    Almpani, Konstantinia; Kolokitha, Olga-Elpis

    2015-02-16

    The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too. PMID:25685759

  3. Space station: The role of software

    NASA Technical Reports Server (NTRS)

    Hall, D.

    1985-01-01

    Software will play a critical role throughout the Space Station Program. This presentation sets the stage and prompts participant interaction at the Software Issues Forum. The presentation is structured into three major topics: (1) an overview of the concept and status of the Space Station Program; (2) several charts designed to lay out the scope and role of software; and (3) information addressing the four specific areas selected for focus at the forum, specifically: software management, the software development environment, languages, and standards. NASA's current thinking is highlighted and some of the relevant critical issues are raised.

  4. Role of acetylcholinesterase in lung cancer

    PubMed Central

    Xi, Hui-Jun; Wu, Ren-Pei; Liu, Jing-Jing; Zhang, Ling-Juan; Li, Zhao-Shen

    2015-01-01

    Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. Intensive research has proven the involvement of this protein in novel functions, such as cell adhesion, differentiation, and proliferation. In addition, several recent studies have indicated that acetylcholinesterase is potentially a marker and regulator of apoptosis. Importantly, AChE is also a promising tumor suppressor. In this review, we briefly summarize the involvement of AChE in apoptosis and cancer, focusing on the role of AChE in lung cancer, as well as the therapeutic consideration of AChE for cancer therapy. PMID:26273392

  5. The role of antibodies in myasthenia gravis.

    PubMed

    De Baets, M; Stassen, M H W

    2002-10-15

    Myasthenia gravis is an autoimmune disease associated with antibodies directed to the postsynaptic acetylcholine receptor. These antibodies reduce the number of receptors. Autoantibodies against AChR and other muscle antigens can be used for the diagnosis of myasthenia gravis and related disorders. The origin and the role of these antibodies in the disease are discussed. Experimental autoimmune myasthenia gravis, an experimental model closely mimicking the disease, has provided answers to many questions about the role of antibodies, complement macrophages and AChR anchor proteins. Genetically modified anti-AChR antibodies may also be used in the future to treat myasthenia. PMID:12220686

  6. The Role of Mitochondria in Apoptosis*

    PubMed Central

    Wang, Chunxin; Youle, Richard J.

    2016-01-01

    Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family members regulate the release of proteins from the space between the mitochondrial inner and outer membrane that, once in the cytosol, activate caspase proteases that dismantle cells and signal efficient phagocytosis of cell corpses. Here we review the extensive literature on proteins released from the intermembrane space and consider genetic evidence for and against their roles in apoptosis activation. We also compare and contrast apoptosis pathways in Caenorhabditis elegans, Drosophila melanogaster, and mammals that indicate major mysteries remaining to be solved. PMID:19659442

  7. The role of psychologists in future spaceflight

    NASA Technical Reports Server (NTRS)

    Helmreich, Robert L.

    1985-01-01

    The need for psychologists to have a more active role in planning space missions is discussed. It is suggested that it would be beneficial if psychologists conducted research aimed at optimizing the organization, composition, and performance of crews; participated in the selection and training of crews; and monitored the actual performance and adjustment of crews during missions. The areas which require further research and the types of research strategies to be implemented are described. The desirable traits for future space personnel and the role of psychologists in mission control are examined.

  8. Drama and Role Playing in Teaching Practice: The Role of Group Works

    ERIC Educational Resources Information Center

    Çerkez, Yagmur; Altinay, Zehra; Altinay, Fahriye; Bashirova, Elnara

    2012-01-01

    The research study aims to explore the essence of group work in drama and role playing for teaching practice inline with the nature of collaborative learning process. This research study has qualitative nature by capturing experiences of volunteer ninety pre-service teachers about group works, gained skills from drama and role playing in their…

  9. Male Therapists' Clinical Bias: Influence of Client Gender Roles and Therapist Gender Role Conflict.

    ERIC Educational Resources Information Center

    Wisch, Andrew F.; Mahalik, James R.

    1999-01-01

    Examines male therapists' gender-role conflict, client sexual orientation, and client emotional expression as they interrelate with clinical judgments about male clients. Results indicate that therapist gender-role-conflict factors, in combination with client sexual orientation and emotional expression, were associated with therapists' ratings of…

  10. Perceived Role Legitimacy and Role Importance of Australian School Staff in Addressing Student Cannabis Use

    ERIC Educational Resources Information Center

    Gates, Peter J.; Norberg, Melissa M.; Dillon, Paul; Manocha, Ramesh

    2013-01-01

    The high prevalence of cannabis use by Australian secondary school students makes schools an ideal setting for the delivery of substance use prevention programs. Although efficacious school-based cannabis prevention programs exist, there is scant research investigating the perceived role legitimacy and role importance of school staff. As such,…

  11. Role Resources and Work-Family Enrichment: The Role of Work Engagement

    ERIC Educational Resources Information Center

    Siu, Oi-ling; Lu, Jia-fang; Brough, Paula; Lu, Chang-qin; Bakker, Arnold B.; Kalliath, Thomas; O'Driscoll, Michael; Phillips, David R.; Chen, Wei-qing; Lo, Danny; Sit, Cindy; Shi, Kan

    2010-01-01

    This article proposes a theoretical model of work-family enrichment and tests the mediating role of work engagement. The inclusion of work engagement extends prior research on work-family interface, and allows for examination of the effects of role resources (job resources, family support) on work-family enrichment. A two-wave survey was conducted…

  12. The Potential Role(s) of Writing in Second Language Development

    ERIC Educational Resources Information Center

    Williams, Jessica

    2012-01-01

    Writing is often seen as having a minor role in second language learning. This article explores recent research that suggests that writing can have a facilitative role in language development. In particular, it focuses on three features of writing: (1) its slower pace, and (2) the enduring record that it leaves, both of which can encourage…

  13. The Impact of Changing Teaching Jobs on Music Teacher Identity, Role, and Perceptions of Role Support

    ERIC Educational Resources Information Center

    Gray, Lori F.

    2011-01-01

    This study utilized symbolic interaction as a framework to examine the impact of mobility on four veteran elementary general music teachers' identities, roles, and perceptions of role support. Previous research has focused on teacher identity formation among preservice and novice teachers; veteran teachers are less frequently represented in the…

  14. What Screens Do: The Role(s) of the Screen in Academic Work

    ERIC Educational Resources Information Center

    Decuypere, Mathias; Simons, Maarten

    2016-01-01

    This article reports of an ethnographic study conducted in two academic research centers. The article is centrally directed at the role of digital technologies and devices in contemporary academic work, and more particularly at the role of the screen in the daily composition of this work. Three central questions are raised. First, which positional…

  15. The Consequences of Role Conflict and Role Ambiguity among Junior High School Administrators in Taiwan.

    ERIC Educational Resources Information Center

    Goldman, Paul; Chang, Derray

    Findings from a study that investigated the consequences of role conflict, role ambiguity, and demographic and organizational factors on work satisfaction and somatic complaints are presented in this paper. Data were derived from a survey administered to 225 Taipei (Taiwan) junior high school administrators, which elicited 211 responses (a 93…

  16. Work Design, Role Conflict, and Role Ambiguity: The Case of Elementary and Secondary Schools.

    ERIC Educational Resources Information Center

    Bacharach, Samuel B.; And Others

    1990-01-01

    Work design outcomes (role conflict, role ambiguity, stress symptomatology, turnover, and militancy) were assessed in New York State. Out of 3,200 mailed surveys, 2,247 teacher questionnaires were returned and analyzed. Managerial and educational policy implications of the findings for elementary school and secondary schools are discussed. (SLD)

  17. The Professional Negotiator: Role Conflict, Role Ambiguity and Motivation To Work.

    ERIC Educational Resources Information Center

    Medford, Robert E.; Miskel, Cecil

    The investigation examined the relationship among role conflict, role ambiguity, and motivation to work of teacher-negotiators. The theoretical rationale for the study was formulated from the finding of Walton and McKersie, Deutsch, Vidmar and McGrath, and Blum concerning the negotiator's conflict with his adversary, his dependence on his…

  18. Becoming a Principal: Role Conception, Initial Socialization, Role-Identity Transformation, Purposeful Engagement.

    ERIC Educational Resources Information Center

    Browne-Ferrigno, Tricia

    2003-01-01

    Exploratory case study of the professional growth of 18 educational practitioners in principal preparation cohort program. Analysis of the data suggests that four major themes influence practitioners' growth: Role conceptualization of principalship, initial socialization into new community of practice, role-identity transformation, and purposeful…

  19. The role of selenium in cancer prevention

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This elucidation of the role of selenium in health occurred over the last six decades. This involved selenium first being found to be a toxicant, followed only later by its recognition as an essential nutrient. This pathway of discovery led to fundamental discoveries in metabolic biochemistry, vir...

  20. Educational Choice: New Roles for Board Members.

    ERIC Educational Resources Information Center

    Randall, Ruth E.

    1990-01-01

    School board members' new leadership roles in planning and implementing school choice programs are described in this article, which draws on the experience of a former Minnesota Commissioner of Education. The first task of the board is to set high expectations in the district and to establish specific policies. Despite the extent of…

  1. Antibodies: Protective, destructive and regulatory role

    SciTech Connect

    Milgrom, F.; Abeyounis, C.J.; Albini, B.

    1985-01-01

    This book contains papers under 10 subject headings. The headings are: Production and Function of Antibodies, Protective Role of Antibodies, Antibodies to Foreign and Neoplastic Cells, Autoantibodies, Regulatory Mechanisms, Allergy, Immune Complexes, Antibodies in Pregnancy and Aging, Administration of Antibodies for Prevention and Therapy, and Abstracts of Poster Presentations.

  2. Vocational Education Institutions' Role in National Innovation

    ERIC Educational Resources Information Center

    Moodie, Gavin

    2006-01-01

    This article distinguishes research--the discovery of new knowledge--from innovation, which is understood to be the transformation of practice in a community or the incorporation of existing knowledge into economic activity. From a survey of roles served by vocational education institutions in a number of OECD countries the paper argues that…

  3. The Future of Instructional Teacher Leader Roles

    ERIC Educational Resources Information Center

    Mangin, Melinda M.; Stoelinga, Sara Ray

    2010-01-01

    In response to increased performance expectations, schools and districts are turning to nonsupervisory, school-based, instructional teacher leader roles to help improve teachers' instruction and enhance student learning. Increased opportunities to learn about teacher leadership may facilitate the implementation and institutionalization of…

  4. Child Participant Roles in Applied Linguistics Research

    ERIC Educational Resources Information Center

    Pinter, Annamaria

    2014-01-01

    Children's status as research participants in applied linguistics has been largely overlooked even though unique methodological and ethical concerns arise in projects where children, rather than adults, are involved. This article examines the role of children as research participants in applied linguistics and discusses the limitations of…

  5. The Role of New Hire Orientation Programs

    ERIC Educational Resources Information Center

    Dunn, Steven; Jasinski, Dale

    2009-01-01

    A vital component of a firm's human resource management is its new hire orientation (NHO) program. The authors' review of extant literature suggests that NHO programs can be organized based on a reconceptualization of human capital. Using their typology, a firm can organize the role and scope of its NHO program, assign responsibility for the…

  6. Elementary Principals' Role in Science Instruction

    ERIC Educational Resources Information Center

    Casey, Patricia; Dunlap, Karen; Brown, Kristen; Davison, Michele

    2012-01-01

    This study explores the role elementary school principals play in science education. Specifically, the study employed an online survey of 16 elementary school principals at high-performing campuses in North Texas to explore their perceptions of how they influenced science education on their campuses. The survey used a combination of Likert-type…

  7. Role-Play in the Science Classroom

    ERIC Educational Resources Information Center

    Worch, Eric A.; Scheuermann, Amy M.; Haney, Jodi J.

    2009-01-01

    The activity shared here is an animal role-playing lesson developed, field-tested, and refined for "Nature's Neighborhood", a newly designed children's education facility at the Toledo Zoo. The activity is targeted at students in kindergarten through second grade, but it can be adapted for use in grades three and four as well. Through students'…

  8. The Role of Cholesterol in Cancer.

    PubMed

    Kuzu, Omer F; Noory, Mohammad A; Robertson, Gavin P

    2016-04-15

    The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is not one. Furthermore, the Cancer Genome Atlas (TCGA) project using next-generation sequencing has profiled the mutational status and expression levels of all the genes in diverse cancers, including those involved in cholesterol metabolism, providing correlative support for a role of the cholesterol pathway in cancer development. Finally, preclinical studies tend to more consistently support the role of cholesterol in cancer, with several demonstrating that cholesterol homeostasis genes can modulate development. Because of space limitations, this review provides selected examples of the epidemiologic, TCGA, and preclinical data, focusing on alterations in cholesterol homeostasis and its consequent effect on patient survival. In melanoma, this focused analysis demonstrated that enhanced expression of cholesterol synthesis genes was associated with decreased patient survival. Collectively, the studies in melanoma and other cancer types suggested a potential role of disrupted cholesterol homeostasis in cancer development but additional studies are needed to link population-based epidemiological data, the TCGA database results, and preclinical mechanistic evidence to concretely resolve this controversy. Cancer Res; 76(8); 2063-70. ©2016 AACR. PMID:27197250

  9. Exploring Sex Roles in African Studies.

    ERIC Educational Resources Information Center

    Lee, David R.

    A method for incorporating an examination of sex roles and position of women into an undergraduate course on geography of Africa is discussed. It is a regional geography course with a cultural emphasis. Five percent of the total instruction is devoted to the examination of women. This is justified because geographical concepts such as spatial…

  10. A Role for Imagery in Mentoring.

    ERIC Educational Resources Information Center

    Fletcher, Sarah

    2000-01-01

    Examples of imagery and visualization in medicine, sports, and preservice teaching explore the potential of these techniques in mentoring relationships. They help proteges develop a positive self-image in a new role, make mentors' experience more explicit, and depict possible selves toward which proteges can work. (SK)

  11. Role modeling excellence in clinical nursing practice.

    PubMed

    Perry, R N Beth

    2009-01-01

    Role modeling excellence in clinical nursing practice is the focus of this paper. The phenomenological research study reported involved a group of 8 nurses identified by their colleagues as exemplary. The major theme revealed in this study was that these exemplary nurses were also excellent role models in the clinical setting. This paper details approaches used by these nurses that made them excellent role models. Specifically, the themes of attending to the little things, making connections, maintaining a light-hearted attitude, modeling, and affirming others are presented. These themes are discussed within the framework of Watson [Watson, J., 1989. Human caring and suffering: a subjective model for health services. In: Watson, J., Taylor, R. (Eds.), They Shall Not Hurt: Human Suffering and Human Caring. Colorado University, Boulder, CO] "transpersonal caring" and [Bandura, A., 1997. Social Learning Theory. Prentice Hall, Englewood Cliffs, NJ] "Social Learning Theory." Particular emphasis in the discussion is on how positive role modeling by exemplary practitioners can contribute to the education of clinical nurses in the practice setting. PMID:18590978

  12. On the Role of Nuclear Energy

    ERIC Educational Resources Information Center

    Parsegian, V. Lawrence

    1974-01-01

    The author elaborates on the thesis that much of the confusion and argument about the role of nuclear energy in meeting the energy needs of the nation and the world is caused by failure to place the known facts in perspective with respect to time, to hazards that accompany the use of energy in any form, to economics, and to ultimate limitations in…

  13. The Role of Computers in Writing Process

    ERIC Educational Resources Information Center

    Ulusoy, Mustafa

    2006-01-01

    In this paper, the role of computers in writing process was investigated. Last 25 years of journals were searched to find related articles. Articles and books were classified under prewriting, composing, and revising and editing headings. The review results showed that computers can make writers' job easy in the writing process. In addition,…

  14. The Role of Technology in SLA Research

    ERIC Educational Resources Information Center

    Chun, Dorothy M.

    2016-01-01

    In this review article for the 20th Anniversary Issue, I look back at research from the last two decades on the role of computer technology in understanding and facilitating second language acquisition (SLA) and forward to what future research might investigate. To be discussed are both how technology has been used to conduct research on SLA…

  15. CTE's Role in Energy and Environmental Sustainability

    ERIC Educational Resources Information Center

    Hyslop, Alisha

    2009-01-01

    ACTE Issue Briefs are designed to highlight the role of career and technical education (CTE) in a broader issue of national interest. Each Brief is designed to strengthen the voice of CTE related to the specific issue and to draw more attention to CTE activities and best practices around the country. The Briefs provide background information,…

  16. The Role of Consultants in Institutional Research

    ERIC Educational Resources Information Center

    Milam, John

    2008-01-01

    Institutional research (IR) is a multifaceted function, occurring at many levels and in many types of settings, addressing numerous audiences, and embracing an almost infinite array of topics. The IR community is well served by understanding the role that consultants play in the panoply of postsecondary education. With the growing complexity and…

  17. Emerging Professional Roles for Teacher Educators.

    ERIC Educational Resources Information Center

    Massanari, Karl; And Others

    Emerging professional roles for teacher educators are examined by three educators from three different viewpoints, and a critique of the positions developed is undertaken by a spokesman for the teacher organization viewpoint of professional development. Karl Massanari examines the changes currently affecting the education of teachers--social,…

  18. Role Taking in Childhood: Some Methodological Considerations

    ERIC Educational Resources Information Center

    Rubin, Kenneth H.

    1978-01-01

    Examines the convergent and discriminant validity of six widely used measures of role-taking skill. The Borke; Rothenberg; Miller, Kessel, and Flavell; Chandler; DeVries; and Glucksberg and Krauss tasks were administered to children in preschool and grades 1, 3, and 5. (Author/JMB)

  19. The Educational Role of Health Sciences Librarians.

    ERIC Educational Resources Information Center

    Rankin, Jocelyn A.; Sayre, Jean Williams

    1993-01-01

    Considers the expanding educational role of health sciences librarians in both academic centers and in hospitals resulting from influences of new educational models and new technology. Topics addressed include undergraduate health sciences education; continuing education; new technology and medical informatics; library educational programs;…

  20. Role and Personality among Adolescent Political Activists.

    ERIC Educational Resources Information Center

    Merelman, Richard M.

    1985-01-01

    Presents findings of a study of adolescent political activism that focused on why so few Americans participate in politics, despite the participatory ideology taught in most schools. Identifies aspects of role, ideology, and personality that encourage participatory motivations among youth. Reports that activist youths tend to be self-critical and…

  1. The Role of Narrative in Multimedia Learning

    ERIC Educational Resources Information Center

    Diamond, Myrna Elyse

    2011-01-01

    This descriptive case study investigated the role of narrative in multimedia learning and teaching and observed how teachers applied their understanding of narrative, and new constructivist technologies, to design multimedia presentations for instruction. The study looked specifically at the cognitive strategies, visual narrative concepts, and…

  2. Thematic Roles, Markedness Alignment and Processing Complexity

    ERIC Educational Resources Information Center

    Lee, Yoonhyoung; Kwon, Youan; Gordon, Peter C.

    2015-01-01

    Two experiments used eye-tracking during reading to investigate the role of the consistency of the relative markedness alignment of noun phrases (NPs) in the processing of complex sentences in Korean. To do so, the animacy of the first NP was varied in both experiments to manipulate the relative markedness of NPs. In addition, case markings of the…

  3. Academic Library Directors: A Managerial Role Profile.

    ERIC Educational Resources Information Center

    Mech, Terrence F.

    1990-01-01

    This examination of the managerial profiles of 354 academic library directors indicates that directors are active primarily in management roles within their libraries, although significant variations exist among directors at doctoral, comprehensive, baccalaureate, and two-year institutions. Work contacts and the importance of human, conceptual,…

  4. The Role of the Faculty Athletics Representative.

    ERIC Educational Resources Information Center

    Cooper, Arthur W.

    1992-01-01

    The faculty athletics representative plays an important role in the athletic-academic relationship. This responsibility includes certifying student-athlete eligibility, reporting academic data as required, evaluating athlete-applicant qualifications and abilities, regular evaluation of athlete performance, and participation in evaluation of…

  5. Siderophores in environmental research: roles and applications

    PubMed Central

    Ahmed, E; Holmström, S J M

    2014-01-01

    Siderophores are organic compounds with low molecular masses that are produced by microorganisms and plants growing under low iron conditions. The primary function of these compounds is to chelate the ferric iron [Fe(III)] from different terrestrial and aquatic habitats and thereby make it available for microbial and plant cells. Siderophores have received much attention in recent years because of their potential roles and applications in various areas of environmental research. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. The aim of this literature review is to outline and discuss the important roles and functions of siderophores in different environmental habitats and emphasize the significant roles that these small organic molecules could play in applied environmental processes. PMID:24576157

  6. EXPECTATIONS FOR THE SCHOOL BOARD ROLE.

    ERIC Educational Resources Information Center

    LIPHAM, JAMES M.; AND OTHERS

    WITHIN 12 WISCONSIN SCHOOL DISTRICTS, THE FOLLOWING GROUPS PROVIDED DATA IN AN INVESTIGATION OF THE EXPECTATIONS FOR THE SCHOOL BOARD ROLE--(1) 1,794 CITIZENS, (2) ALL MAYORS, CITY MANAGERS OR VILLAGE PRESIDENTS, CITY OR VILLAGE COUNCILMEN, AND TOWNSHIP CHAIRMEN WITHIN EACH DISTRICT, (3) 20 RANDOMLY SELECTED TEACHERS FROM EACH DISTRICT, AND (4)…

  7. APA's Role in Fostering Good Testing Practices.

    ERIC Educational Resources Information Center

    Camara, Wayne J.

    Psychological testing has played a major role in the American Psychological Association (APA) because testing and assessment are important aspects of what psychologists do; tests assist psychologists in diagnosis and treatment. From its earliest years, APA has had one or more committees concerned with testing. The present Committee on…

  8. Teachers' Burnout, Depression, Role Ambiguity and Conflict

    ERIC Educational Resources Information Center

    Papastylianou, Antonia; Kaila, Maria; Polychronopoulos, Michael

    2009-01-01

    The present study investigates issues associated with teachers' burnout in primary education as related to depression and role conflict-ambiguity. At the time of the study the participants (562 teachers) were working in seventy nine (79) Primary Education State Schools in Greece (Athens and two prefectures in the southern part of the country). The…

  9. The Chancellor's Role in a Presidential Transition

    ERIC Educational Resources Information Center

    Appleton, James R.; Dorsey, Stuart

    2009-01-01

    Successful transitions involving a formal role for the former president, such as chancellor, are rare enough that the authors think theirs is an exceptional experience and is worth sharing, especially given the bulge of presidential retirements anticipated over the next decade. The authors believe that this model of transition can be successful,…

  10. The role of CRAC channel in asthma.

    PubMed

    Kaur, Manminder; Birrell, Mark A; Dekkak, Bilel; Reynolds, Sophie; Wong, Sissie; De Alba, Jorge; Raemdonck, Kristof; Hall, Simon; Simpson, Karen; Begg, Malcolm; Belvisi, Maria G; Singh, Dave

    2015-12-01

    Asthma is increasing globally and current treatments only manage a proportion of patients. There is an urgent need to develop new therapies. Lymphocytes are thought to play a central role in the pathophysiology of asthma through the production of inflammatory mediators. This is thought to be via the transcription factor NFAT which in turn can be activated through Ca(2+) release-activated Ca(2+) (CRAC) channels. The aim of this work was to investigate the role of CRAC in clinical and pre-clinical models of allergic asthma. Initial data demonstrated that the NFAT pathway is increased in stimulated lymphocytes from asthmatics. To confirm a role for the channel we showed that a selective inhibitor, Synta 66, blocked mediator production from lymphocytes. Synta 66 inhibited CD2/3/28 induced IL-2, IL-7, IL-13 & IFNΥ in a concentration-dependent manner in healthy and severe asthma donors, with over 60% inhibition observed for all cytokines. NFAT pathway was also increased in a pre-clinical asthma model. In this model we have demonstrated that CRAC played a central role in the airway inflammation and late asthmatic response (LAR). In conclusion, our data provides evidence that suggests targeting CRAC channels could be of therapeutic benefit for asthma sufferers. PMID:26344428

  11. The State Role in School Desegregation.

    ERIC Educational Resources Information Center

    Mogin, Bert

    This study was designed to examine the role of State Educational Agencies (SEAs) in desegregation activity. It examines the nature of SEA activity and identifies common elements important to effective programs. It also assesses whether these activities and elements could serve as models for other states, and determines the need and desire of the…

  12. Teachers' Perceptions of the Principal's Role.

    ERIC Educational Resources Information Center

    Giannangelo, Duane M.; Malone, Marguerite G.

    To gain an insight into teachers' perceptions of the role and responsibilities of school principals, 143 teachers from a large metropolitan area were surveyed. They were asked to respond to the following four questions: (1) What do you believe are the most important functions of the principal?; (2) What do principals say to teachers are the…

  13. The Role of Gesture in Meaning Construction

    ERIC Educational Resources Information Center

    Singer, Melissa; Radinsky, Joshua; Goldman, Susan R.

    2008-01-01

    This article examines the role of gesture in the shared meaning-making processes of 6th-grade students studying plate tectonics using a data visualization tool; specifically, a geographic information system. Students' verbal and gestural characterizations of key concepts of plate motions (i.e., "subduction", "rift", and "buckling") were…

  14. The Managerial Roles of Chief Academic Officers.

    ERIC Educational Resources Information Center

    Mech, Terrence

    1997-01-01

    Examined the managerial roles emphasized by chief academic officers (CAOs) at 349 colleges and universities classified by the Carnegie Foundation as Comprehensive I institutions. What emerged was a picture of the CAO as an internally focused senior-level team manager in a collegial organization trying to develop and maintain a smooth-running…

  15. Linguistic Relativity: The Role of the Bilingual.

    ERIC Educational Resources Information Center

    Barnett, George A.

    The role of linguistic relativity was examined through the use of multidimensional scaling (MDS). Direct pair comparisons of the similarity among a set of translated equivalent lexical items dealing with the mass media were made by subjects monolingual in English or French or bilingual using either of the languages. Using MDS as a measure of…

  16. Roles of Naturalistic Observation in Comparative Psychology

    ERIC Educational Resources Information Center

    Miller, David B.

    1977-01-01

    "Five roles are considered by which systematic, quantified field research can augment controlled laboratory experimentation in terms of increasing the validity of laboratory studies." Advocates that comparative psychologists should "take more initiative in designing, executing, and interpreting our experiments with regard to the natural history of…

  17. Rethinking Education--Emerging Roles for Teachers

    ERIC Educational Resources Information Center

    Dar, Fatima Rehan

    2015-01-01

    The purpose of the study was to find out how teachers role modeled and taught empathetic and pro-social skills at the primary level. The study was qualitative in nature and followed a case study approach. Observations of regular English language classes were done from Grades 1-5 to see if class lessons incorporated the said themes and whether…

  18. Changing Roles of Mental Health Professionals.

    ERIC Educational Resources Information Center

    Garai, Josef E.

    The roles that mental health professionals must play to facilitate the prevention of mental illness and the introduction of mentally healthy attitudes in our society is discussed. Mental health professionals must re-examine the meaning of mental health in the context of the current world situation and ask themselves to what extent they are…

  19. THE ROLE OF THE COMMUNITY COLLEGE PRESIDENT.

    ERIC Educational Resources Information Center

    GILLIE, ANGELO C.

    FOUR ASPECTS OF THE COMMUNITY COLLEGE PRESIDENT'S ROLE ARE PLANNING A CAMPUS, ECONOMIC PLANNING, PROGRAM PLANNING AND MERGING OF INSTITUTIONS. FROM THE EARLIEST POSSIBLE MOMENT, THE PRESIDENT SHOULD BE INVOLVED IN CAMPUS PLANNING. HE MUST USE HIS KNOWLEDGE OF THE COMMUNITY, ITS EMPLOYMENT, POPULATION, SOCIAL CHARACTERISTICS, EDUCATIONAL…

  20. The Role of Meditation in Addiction Recovery

    ERIC Educational Resources Information Center

    Pruett, James M.; Nishimura, Nancy J.; Priest, Ronnie

    2007-01-01

    The authors examined the role of meditation as an important component in addiction recovery. Successful addiction recovery is often related to an individual's ability to develop and use a repertoire of coping behaviors, including the ability to maintain an ongoing awareness of one's vulnerability. These learned behaviors serve as reliable…

  1. The Arabic Language; Its Role in History.

    ERIC Educational Resources Information Center

    Chejne, Anwar G.

    This book reviews the position Arabic has traditionally occupied in Arab-Muslim society, and its role in the task of building a nation state. The work is aimed to aid students of Arabic and Arabic lore and add to a greater understanding of the historical factors which made Arabic a revered language in Arabic-Muslim cultural and religious…

  2. A Role-Play Rorschach Procedure

    ERIC Educational Resources Information Center

    Bricklin, Barry

    1975-01-01

    Three subjects were used in a role playing study based on the subject's own Rorschach responses. The results proved to be valuable as an aspect of therapeutic involvement. Results also help to expand and clarify the psychological meaning of Rorschach images. (Author/DEP)

  3. The Changing Role of CBOs in CETA.

    ERIC Educational Resources Information Center

    Rubio, Gloria

    1979-01-01

    Explains how community-based organizations (CBOs) have become increasingly ineffective in fighting unemployment and how the role of such organizations has become that of watchdog for CETA activities since that 1973 legislation. Details the current conflicts between SER, CETA, and local government in Houston, Texas. (SB)

  4. The Crucial Role of Recess in Schools

    ERIC Educational Resources Information Center

    Ramstetter, Catherine L.; Murray, Robert; Garner, Andrew S.

    2010-01-01

    Background: Recess is at the heart of a vigorous debate over the role of schools in promoting optimal child development and well-being. Reallocating time to accentuate academic concerns is a growing trend and has put recess at risk. Conversely, pressure to increase activity in school has come from efforts to combat childhood obesity. The purpose…

  5. Essential Role of Culture in Developmental Psychology

    ERIC Educational Resources Information Center

    Miller, Joan G.

    2005-01-01

    This chapter argues for the essential role of culture in forming the basic constructs and theories of developmental psychology. The case is made for the need to overcome the cultural insularity of core developmental concepts and methods in order to create a psychology that is more truly universal.

  6. Fostering Teacher Learning: Reflections on Leadership Roles

    ERIC Educational Resources Information Center

    Power, Alayne; Boutilier, Amy

    2009-01-01

    Over the months of a graduate course in literacy education, the authors engaged in many conversations about their leadership roles in the district in which they both work. Their schools are actively engaged in school improvement with a focus on enhancing student achievement. The district and the provincial Department of Education have given…

  7. Redesigning Our Role While Redesigning Our Libraries

    ERIC Educational Resources Information Center

    Bradburn, Frances Bryant

    2013-01-01

    This article describes a process one librarian discovered and implemented as she observed the changing role of the librarian and the library. Frustration was growing due to the gradual erosion of school libraries as they struggled to remain, with electronic books, video streaming, and databases supplanting many of the physical resources in the…

  8. The Counselor's Role: A Cooperative Exploration.

    ERIC Educational Resources Information Center

    Warthen, Mary Ann; Carson, W. E.

    The basic format of the conference incorporated orientation to student needs and to the proper utilization of professional talent, visual simulations of counselor roles, and exercise in group consensus, and a reaction panel. To present a picture of what the counselor should be doing from the viewpoint of student needs, Dr. Walter Busby spoke on…

  9. The Community College's Role in the Community

    ERIC Educational Resources Information Center

    Vaughan, George B.

    2007-01-01

    In this article, the author examines the "citizenship role" of community colleges, which causes them to devote time and resources to activities that have little to do with higher education: Is it a legitimate one for community colleges, or does it siphon off resources and energy that should be devoted to the primary educational mission? He draws…

  10. Role of Teacher in Personal Learning Environments

    ERIC Educational Resources Information Center

    Shaikh, Zaffar Ahmed; Khoja, Shakeel Ahmed

    2012-01-01

    This paper aims to discuss the changing roles and competencies of a teacher in context of prevailing developments accomplished by the vast availability of social software, which have made easy the development of Personal Learning Environments (PLEs). This has been accomplished by an in-depth review of the literature on teacher's socially situated…

  11. CTE's Role in Worker Retraining. Issue Brief

    ERIC Educational Resources Information Center

    Association for Career and Technical Education (NJ1), 2010

    2010-01-01

    This Issue Brief will explore the essential role that career and technical education programs play in addressing many of the issues faced by unemployed and underemployed workers. These programs target the adult learner through short-term and accelerated courses; utilize flexible learning approaches to account for students' other responsibilities;…

  12. From Semantic Roles to Temporal Information Representation

    NASA Astrophysics Data System (ADS)

    Llorens, Hector; Navarro, Borja; Saquete, Estela

    The automatic treatment of temporal elements of natural language has become a very important issue among NLP community. Recently, TimeML annotation scheme has been adopted as standard for temporal information representation by a large number of researchers. There are few TimeML resources for languages other than English whereas there exist semantic roles annotated corpora and automatic labeling tools for several languages. The objective of this paper is to study if semantic roles resources can be exploited to generate TimeML corpora. An analysis of the similarities and differences between the temporal semantic role and TimeML elements has been carried out, focusing on temporal expressions (TIMEX3). Using this analysis, an approach consisting of a set of transformation rules between semantic roles and TIMEX3 has been implemented. It has been evaluated in TIMEX3 identification for English and Spanish obtaining same quality results (76.85% F β= 1 AVG), which suggests that it could be also valid for other languages.

  13. The Role of the State Approving Agency.

    ERIC Educational Resources Information Center

    Dickinson, Bernell C.

    1987-01-01

    Discusses the role of the State Approving Agency (SAA) in assisting states with their Veterans Education Programs that originated with the G.I. Bill. SAAs continue to help states by providing monitoring services and advising or consulting as needed. (JOW)

  14. The Federal Role in Higher Education.

    ERIC Educational Resources Information Center

    Bell, T. H.

    This speech historically reviews what the federal role is, and what it ought to be, in terms of national priorities, and in terms of what is appropriate within national goals for the present and foreseeable future. Emphasis is placed on the GI Bill of Rights, the Higher Education Act of 1965, the Guaranteed Student Loan Program, and the State…

  15. Dyslexia: The Role of the Cerebellum

    ERIC Educational Resources Information Center

    Fawcett, Angela; Nicolson, Rod

    2004-01-01

    Introduction: In this review article we outline the thinking and evidence behind our hypothesis that the problems suffered by dyslexic people may be attributable to cerebellar deficit. Method: Firstly, we provide an overview of recent evidence that proposes a central role for the cerebellum in cognitive skills, in particular those scaffolded by…

  16. Interim Report: Program Development Specialist's Role.

    ERIC Educational Resources Information Center

    Coon, George E.

    In a memorandum to the Chief of Planning and Program Development, Teacher Corps, the Program Development Specialist for the Pontiac Urban Corps in Oakland examines the role of the program development specialist. Although the program was successful in that 31 beginning teachers were placed and modules were developed in three discipline areas, the…

  17. The Changing Role of the CTO

    ERIC Educational Resources Information Center

    Dessoff, Alan

    2011-01-01

    The role of a district's technology leader, known by a variety of titles including "chief technology officer" (CTO), "chief information officer" (CIO), "director of technology" and others, is changing rapidly in school systems around the country. These administrators principally have managed the nuts and bolts of hardware and software but now are…

  18. Assuming Multiple Roles: The Time Crunch.

    ERIC Educational Resources Information Center

    McKitric, Eloise J.

    Women's increased labor force participation and continued responsibility for most household work and child care have resulted in "time crunch." This strain results from assuming multiple roles within a fixed time period. The existence of an egalitarian family has been assumed by family researchers and writers but has never been verified. Time…

  19. Forensic Learning Disability Nursing Role Analysis

    ERIC Educational Resources Information Center

    Mason, Tom; Phipps, Dianne; Melling, Kat

    2011-01-01

    This article reports on a study carried out on the role constructs of forensic and nonforensic Learning Disability Nursing in relation to six binary themes. The aims were to identify if there were differences in perceptions of forensic learning disability nurses and nonforensic learning disability nurses in relation to the six binary themes of the…

  20. Aquaporins: Their role in gastrointestinal malignancies.

    PubMed

    Nagaraju, Ganji Purnachandra; Basha, Riyaz; Rajitha, Balney; Alese, Olatunji Boladale; Alam, Afroz; Pattnaik, Subasini; El-Rayes, Bassel

    2016-04-01

    Aquaporins (AQPs) are small (~30 kDa monomers) integral membrane water transport proteins that allow water to flow through cell membranes in reaction to osmotic gradients in cells. In mammals, the family of AQPs has thirteen (AQP0-12) unique members that mediate critical biological functions. Since AQPs can impact cell proliferation, migration and angiogenesis, their role in various human cancers is well established. Recently, AQPs have been explored as potential diagnostic and therapeutic targets in gastrointestinal (GI) cancers. GI cancers encompass multiple sites including the colon, esophagus, stomach and pancreas. Research in the last three decades has revealed biological aspects and signaling pathways critical for the development of GI cancers. Since the majority of these cancers are very aggressive and rapidly metastasizes, identifying effective targets is crucial for treatment. Preclinical studies have utilized inhibitors of specific AQPs and knock down of AQP expression using siRNA. Although several studies have explored the role of AQPs in colorectal, esophageal, gastric, hepatocellular and pancreatic cancers, there is no comprehensive review compiling the available information on GI cancers as has been published for other malignancies such as ovarian cancer. Due to the similarities and association of various sites of GI cancers, it is helpful to consider these results collectively in order to better understand the role of specific AQPs in critical GI cancers. This review summarizes the current knowledge of the role of AQPs in GI malignancies with particular focus on diagnosis and therapeutic applications. PMID:26780474

  1. The Role of Trust in Innovation

    ERIC Educational Resources Information Center

    Dovey, Ken

    2009-01-01

    Purpose: The purpose of this paper is to explore the role of trust in the collaborative learning processes that underpin innovation as a competitive strategy in organizations. Design/methodology/approach: As a conceptual paper, the argument is framed by academic perspectives, drawn from the academic literature on the topic and by professional and…

  2. Creating Civil Societies: The University's Role.

    ERIC Educational Resources Information Center

    Daxner, Michael

    2003-01-01

    The president emeritus of Carl von Ossietzky University in Germany describes a research project examining the university's role in creating a democratic citizenship, prompted by the European Union's need to create societies in which citizens can participate actively in determining their own future. (EV)

  3. The Role of Conversation in Technology Education

    ERIC Educational Resources Information Center

    Fox-Turnbull, Wendy

    2010-01-01

    This article investigates recent literature in the area of classroom conversation and dialogue with the aim of gaining a better understanding of the role that classroom conversation and dialogue plays in learning. It also investigates literature on the constructivist, collaborative nature of technology education and suggests that to enhance our…

  4. Adult Roles & Functions. Objective Based Evaluation System.

    ERIC Educational Resources Information Center

    West Virginia State Vocational Curriculum Lab., Cedar Lakes.

    This book of objective-based test items is designed to be used with the Adult Roles and Functions curriculum for a non-laboratory home economic course for grades eleven and twelve. It contains item banks for each cognitive objective in the curriculum. In addition, there is a form for the table of specifications to be developed for each unit. This…

  5. Integrating Technology: The Principals' Role and Effect

    ERIC Educational Resources Information Center

    Machado, Lucas J.; Chung, Chia-Jung

    2015-01-01

    There are many factors that influence technology integration in the classroom such as teacher willingness, availability of hardware, and professional development of staff. Taking into account these elements, this paper describes research on technology integration with a focus on principals' attitudes. The role of the principal in classroom…

  6. [The role of endothelial lipase in atherogenesis].

    PubMed

    Pierart Z, Camila; Serrano L, Valentina

    2012-03-01

    Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis of the enzyme is regulated by interleukin 1 and tumor necrosis factor a. These inflammatory cytokines play a role in diabetes and vascular disease. An increase in vascular mechanical forces, that play a role in atherogenesis, also increase the synthesis of EL. There is expression of EL in endothelial cells, macrophages and muscle cells of atherosclerotic lesions of coronary arteries of humans. This evidence leads to the suspicion that EL plays a role in atherogenesis. There are also higher plasma levels of EL in subjects with type 2 diabetes, who are especially susceptible to the development of vascular lesions. Therefore the inhibition of EL could play an important role in HDL metabolism and could be a new therapeutic strategy for the prevention of atherosclerosis. PMID:22689120

  7. Biofilms: Their Role in Dermal Fillers

    PubMed Central

    Sadashivaiah, Anitha B; Mysore, Venkataram

    2010-01-01

    Fillers are commonly used in several aesthetic indications. Though considered safe, several side effects have been reported. The role of biofilms in the causation of some of these side effects has been elucidated only recently and this article presents a short review of the subject. PMID:20606988

  8. Higher Education's Role in "Education for Sustainability"

    ERIC Educational Resources Information Center

    Shephard, Kerry

    2010-01-01

    This paper describes some of the drivers for "education for sustainability" that exist in universities and also explores some of the rationales that underpin higher education's reluctance to engage more formally in education for sustainability. It attempts to provide a balanced commentary on the role and capability of higher education in promoting…

  9. Occupational Sex Roles and Occupational Prestige.

    ERIC Educational Resources Information Center

    Simerly, D. Emily; Ruback, R. Barry

    Past studies on the sex-typing of occupations have used a single bipolar scale, ranging from masculinity to femininity. An empirical examination of both occupational sex roles and occupational prestige was conducted using two unipolar scales to assess masculinity and femininity. College students (N=183) rated 94 occupations, which were then…

  10. Narcissism, Sex Roles, and Self-Functioning.

    ERIC Educational Resources Information Center

    Watson, P. J.; And Others

    1987-01-01

    Examines the relationship between gender, sex role, and narcissism. Data indicated that males and masculine individuals were not higher in their levels of maladaptive narcissism, that an adjusted narcissism was more obvious in males and in masculine subjects, and that femininity appeared to inhibit the display of an unhealthy exploitative…

  11. My Role as an EPA Scientist

    EPA Science Inventory

    I will first describe my role as a Research Ecologist with the EPA’s Office of Research and Development, National Health and Environmental Effects Research Laboratory, Western Ecology Division, in Corvallis, Oregon, an example of a government agency conducting research in E...

  12. Network Literacy: A Role for Libraries?

    ERIC Educational Resources Information Center

    McClure, Charles R.

    1994-01-01

    Explores the impact of electronic networking on social evolution, new notions of literacy, and social equity. Strategies to develop the Internet/NREN as a vehicle for reconnecting segments of society and promoting a network-literate population are needed. The role of libraries and the educational community in accomplishing these objectives must be…

  13. The Role of the Supreme Court.

    ERIC Educational Resources Information Center

    Berger, Raoul

    Chapter 1 of a book on school law, this article analyzes the role of the U.S. Supreme Court, and contends that there has been a judicial takeover of functions that had been delegated by the Constitution to the states and to the people. Specifically, the author argues that much of the Supreme Court's expansion of its powers rests on the selective…

  14. Ceramide in apoptosis: a revisited role.

    PubMed

    Levade, Thierry; Malagarie-Cazenave, Sophie; Gouazé, Valérie; Ségui, Bruno; Tardy, Claudine; Betito, Susan; Andrieu-Abadie, Nathalie; Cuvillier, Olivier

    2002-08-01

    The sphingolipid ceramide has recently emerged as a new transducer or modulator of apoptotic cell death. This function, however, has recently been challenged. Here, in the light of recent observations, the role of ceramide in apoptosis signaling is discussed. PMID:12374195

  15. Role of lactoferrin in the tear film.

    PubMed

    Flanagan, J L; Willcox, M D P

    2009-01-01

    The surface of the eye provides an inert barrier against infection. Through its unique combination of antimicrobial action and anti-inflammatory activities lactoferrin (Lf) in the tear film plays an important role in the maintenance of ocular health. In order to maintain clarity the eye must provide immunological defense without immunopathology. Along with physical barriers, soluble plasma factors and other proteins such as lysozyme, Lf produced by the acinar cells of the lacrimal gland serves a number of roles in defense for this purpose. Lf in tears provides antimicrobial efficacy by binding free iron thus reducing the availability of iron necessary for microbial growth and survival as well as pathogenesis. Lf has been shown to inhibit biofilm formation and thus may play a role in protecting contact lens surfaces from colonization. Virus particles' entry into epithelial cells is inhibited by Lf while an excess of Lf in tear film is thought to limit the opportunistic Lf-mediated bridging of adenovirus and host cell that occurs in other tissues. Lf dampens the classical complement activation pathway by binding to markers of inflammation and immune activation while pathogen-associated molecular patterns such as lipopolysaccharide (LPS) are targeted by Lf for removal through tears and hydrodynamic flushing. This review focuses on the role of Lf in human tear film and its contribution to ocular health during contact lens wear. PMID:18718499

  16. The Role of Schools in Area Regeneration

    ERIC Educational Resources Information Center

    Cummings, Colleen; Dyson, Alan

    2007-01-01

    There is evidence in recent Government policy in England of the emergence of a wider role for schools in relation to the neighbourhoods they serve. In particular, the National Strategy for Neighbourhood Renewal in England sets the work of schools within the context of an overarching regeneration strategy. The study reported here, sponsored by the…

  17. Transendothelial Transport and Its Role in Therapeutics

    PubMed Central

    Upadhyay, Ravi Kant

    2014-01-01

    Present review paper highlights role of BBB in endothelial transport of various substances into the brain. More specifically, permeability functions of BBB in transendothelial transport of various substances such as metabolic fuels, ethanol, amino acids, proteins, peptides, lipids, vitamins, neurotransmitters, monocarbxylic acids, gases, water, and minerals in the peripheral circulation and into the brain have been widely explained. In addition, roles of various receptors, ATP powered pumps, channels, and transporters in transport of vital molecules in maintenance of homeostasis and normal body functions have been described in detail. Major role of integral membrane proteins, carriers, or transporters in drug transport is highlighted. Both diffusion and carrier mediated transport mechanisms which facilitate molecular trafficking through transcellular route to maintain influx and outflux of important nutrients and metabolic substances are elucidated. Present review paper aims to emphasize role of important transport systems with their recent advancements in CNS protection mainly for providing a rapid clinical aid to patients. This review also suggests requirement of new well-designed therapeutic strategies mainly potential techniques, appropriate drug formulations, and new transport systems for quick, easy, and safe delivery of drugs across blood brain barrier to save the life of tumor and virus infected patients. PMID:27355037

  18. Sport and Sex-Role Orientation.

    ERIC Educational Resources Information Center

    Fisher, A. Craig

    Psychosexual personality is not exclusively a postnatal and learned phenomenon. Three biologically-based sex differences can be cited as having promoted status differentiation between males and females. These are (a) greater physical strength of males, (b) greater aggressiveness of males, and (c) child-rearing and nursing roles of females. The…

  19. The Roles of the Future Library.

    ERIC Educational Resources Information Center

    Murr, Lawrence E.; Williams, James B.

    1987-01-01

    Discusses emerging roles for the library and librarian, including services in the following areas: (1) special collection management and reference; (2) information systems; (3) expert systems; (4) electronic publishing; (5) telecommunications networking; and (6) computer support. The technologies of artificial intelligence, graphic imaging,…

  20. Clinical role modelling: uncovering hidden knowledge.

    PubMed

    Davies, E

    1993-04-01

    Those responsible for the education of nurses are well aware of the need to reconcile the art and science of nursing so that future practitioners can be prepared to offer a humanistic and professional service to society. One way to assist students in this integration is to provide them with opportunities for role modelling as a means of discovering the knowledge embedded in clinical practice. A study of first-year undergraduate students undertaking a course which provides such opportunities in a number of practice settings was carried out to determine whether the observation of clinical role models does lead to knowledge discovery. The study, which used a grounded theory approach, indicated that the major aspect of nursing uncovered by the students through observation of clinical role models was that of provision of direct care. They articulated their values in relation to 'good' and 'bad' care and identified those attributes of nurses which they considered contributed to these care positions. In addition, they were able to recognize creativity and flexibility in practitioners and to relate these attributes to the ability to provide individualized, context-specific care. There was some uncovering of aspects of the nurse's role in maintaining their own professional competence, socializing neophytes into the profession and collaborating with the members of the multi-disciplinary health care team. PMID:8496511

  1. The Role of the Diabetes Educator.

    ERIC Educational Resources Information Center

    Hunt, C.

    1993-01-01

    Diabetes educators have a dual role--to prevent eye disease and to help people with diabetes who are visually impaired achieve and maintain their desired level of independence. Familiarity with the range of adaptive equipment available and utilization of the professional association, the American Association of Diabetes Educators, can assist in…

  2. The Role of Statistics in Kosovo Enterprises

    ERIC Educational Resources Information Center

    Gjonbalaj, Muje; Dema, Marjan; Miftari, Iliriana

    2009-01-01

    Considering science as the main contributor to contemporary developments has encouraged us to raise a scientific discussion regarding the role of statistics in business decision-making and economic development. Statistics, as an applicative science, is growing and being widely applied in different fields and professions. Statistical thinking is…

  3. Beliefs About Rape and Women's Social Roles.

    ERIC Educational Resources Information Center

    Costin, Frank; And Others

    The hypothesis that views of rape which place women at a disadvantage are positively related to beliefs which restrict the rights and roles of women in our society is tested. Two scales, the R scale and the W scale, based on a survey of beliefs about rape (Hubert Feild) and the attitudes toward women's scale (Janet Spence and Robert Helmreich),…

  4. Attitudes toward Sexual Discrimination and Nontraditional Roles.

    ERIC Educational Resources Information Center

    Dillon, Linda S.

    1986-01-01

    The author surveyed the attitudes of 1,551 North Carolinians toward sexual discrimination and nontraditional work roles. Sixty-three percent of all respondents thought that women had not been treated equally with men in being allowed to earn enough money to support themselves independently. Women were significantly different than men in their…

  5. Eating Disorders: The School Counselor's Role.

    ERIC Educational Resources Information Center

    Omizo, Sharon A.; Omizo, Michael M.

    1992-01-01

    Discusses role of school counselor in providing assistance to students who may be at risk for developing anorexia nervosa and bulimia and students who already display behaviors and physical symptoms of either of these illnesses. Addresses specific concerns regarding intervention strategies used by the school counselor in the student's recovery…

  6. The Occupations of Literacy: Occupational Therapy's Role

    ERIC Educational Resources Information Center

    Frolek Clark, Gloria

    2016-01-01

    Nationally, student proficiency in reading and writing is very low and requires ongoing focus from state and local agencies. With almost 25% of occupational therapists working in early intervention and school settings (AOTA, 2015), their role of facilitating literacy (e.g., reading, writing, speaking and listening) is critical. Occupational…

  7. Collaboration using roles. [in computer network security

    NASA Technical Reports Server (NTRS)

    Bishop, Matt

    1990-01-01

    Segregation of roles into alternative accounts is a model which provides not only the ability to collaborate but also enables accurate accounting of resources consumed by collaborative projects, protects the resources and objects of such a project, and does not introduce new security vulnerabilities. The implementation presented here does not require users to remember additional passwords and provides a very simple consistent interface.

  8. Media Roles and Legislators' New Media Use.

    ERIC Educational Resources Information Center

    Riffe, Daniel

    1990-01-01

    Surveys 82 Alabama legislators and finds officials' views of the press as adversary or agent of consensus relates to perceived value of media for job-relevant information. Suggests a dysfunction of the "watch-dog" role because those believing the consensus model found the press more useful than those seeing the press as an adversary. (MG)

  9. Role of the Military, Unit III.

    ERIC Educational Resources Information Center

    Robinson, Terry

    This unit on the role of the military in Wyoming history provides activities which focus on the system of forts which began in 1849, Indian conflicts, World War II, and the Army and Air National Guard. Student activities include illustrating various battles, locating major Wyoming forts on a map, field trips to F.E. Warren Air Force Base and Fort…

  10. Defining the Role of Academics in Accountability

    ERIC Educational Resources Information Center

    El-Khawas, Elaine

    2009-01-01

    The policy debate on accountability in higher education has been vigorous in many countries, but it has focused primarily on broad objectives or approaches. Limited attention has been paid to the mechanisms by which universities would implement accountability objectives and to the critical role of academics in developing ways to assess learning…

  11. Teachers' Perceptions of Their Students' Gender Roles.

    ERIC Educational Resources Information Center

    Tatar, Moshe; Emmanuel, Gina

    2001-01-01

    Investigated Israeli teachers' attitudes and perceptions regarding their students' gender roles. Surveys of 221 elementary and secondary teachers indicated no extreme egalitarian or chauvinistic responses. Elementary and female teachers tended to give more gender egalitarian responses. Only 15 percent of respondents had attended courses on gender…

  12. Vocational Education's Role in Developing Technological Literacy.

    ERIC Educational Resources Information Center

    Dyrenfurth, Michael J.; Lemons, Dale

    1982-01-01

    The authors discuss the role industrial arts and vocational education must play in developing the technological literacy of our youth. This literacy includes understanding technology (production, energy and power, and communication), consumer knowledge of technological products, ability to use microcomputers, and increased comfort with…

  13. The Role of Shame in Suicide.

    ERIC Educational Resources Information Center

    Lester, David

    1997-01-01

    Explores the differences between shame and guilt in suicide, with a focus on experiential and developmental factors and on behavioral reactions to these emotions. Illustrates the role of shame as a motive for suicidal behavior and provides examples of suicidal behavior in Greek tragedy, Asian cultures, jails, and famous individuals. (RJM)

  14. Macrophages: Their Emerging Roles in Bone.

    PubMed

    Sinder, Benjamin P; Pettit, Allison R; McCauley, Laurie K

    2015-12-01

    Macrophages are present in nearly all tissues and are critical for development, homeostasis, and regeneration. Resident tissue macrophages of bone, termed osteal macrophages, are recently classified myeloid cells that are distinct from osteoclasts. Osteal macrophages are located immediately adjacent to osteoblasts, regulate bone formation, and play diverse roles in skeletal homeostasis. Genetic or pharmacological modulation of macrophages in vivo results in significant bone phenotypes, and these phenotypes depend on which macrophage subsets are altered. Macrophages are also key mediators of osseous wound healing and fracture repair, with distinct roles at various stages of the repair process. A central function of macrophages is their phagocytic ability. Each day, billions of cells die in the body and efferocytosis (phagocytosis of apoptotic cells) is a critical process in both clearing dead cells and recruitment of replacement progenitor cells to maintain homeostasis. Recent data suggest a role for efferocytosis in bone biology and these new mechanisms are outlined. Finally, although macrophages have an established role in primary tumors, emerging evidence suggests that macrophages in bone support cancers which preferentially metastasize to the skeleton. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as therapeutic and regenerative approaches vital for skeletal health. PMID:26531055

  15. Principals' Collaborative Roles as Leaders for Learning

    ERIC Educational Resources Information Center

    Kitchen, Margaret; Gray, Susan; Jeurissen, Maree

    2016-01-01

    This article draws on data from three multicultural New Zealand primary schools to reconceptualize principals' roles as leaders for learning. In doing so, the writers build on Sinnema and Robinson's (2012) article on goal setting in principal evaluation. Sinnema and Robinson found that even principals hand-picked for their experience fell short on…

  16. The Role of the Principal in Development.

    ERIC Educational Resources Information Center

    Konzen, Joel M.

    Principals have an essential role in school development that includes an institution's effort to reach its goals and objectives. The main responsibility for development lies in the principal's knowledge, team building, involvement, and volunteer gathering. Setting the stage for development means establishing quality as a comprehensive goal,…

  17. Congress Takes Activist Role in Science Policy

    ERIC Educational Resources Information Center

    Polinger, Madeleine

    1972-01-01

    Second of three articles that probe the nature of federal involvement in science. The role of Congress in formulating and implementing science policy is changing to a more activist one. Congress is seetting up mechanisms to interpret the flood of information used in making policy decisions. (Author/TS)

  18. The Literacy Educator's Role in Suicide Prevention

    ERIC Educational Resources Information Center

    Fisher, Douglas

    2005-01-01

    Suicide, the second leading cause of death for adolescents in the United States, is preventable. Nearly 80% of individuals who commit suicide have demonstrated signs well in advance. Adolescent suicide prevention efforts require collaboration with teachers--individuals who know students well. Literacy educators have a role in suicide…

  19. Defining Role in the New Classroom Teams.

    ERIC Educational Resources Information Center

    Thomas, Gary

    1991-01-01

    Interviews with four teachers, one parent, one assistant, and two ancillary helpers found that classroom teams possess little structure with minimal role definition. Participants erect defenses against the lack of definition and use a process termed "fraternity" to get along with one another and camouflage uncertainties and tensions. (SK)

  20. Sport Nutritionist: A New Sport Education Role

    ERIC Educational Resources Information Center

    Martin, Matthew R.; Zimmerman, Ryan; Ciotto, Carol

    2015-01-01

    Considering the challenges associated with adolescent obesity and the need for innovative and meaningful physical education curricula, the authors of this article decided to create a new sport education role to help students learn about the fundamental nutritional concepts and practices that contribute to a healthy and active lifestyle. The new…

  1. Sex Roles as an Androcentric Vision.

    ERIC Educational Resources Information Center

    Rosenthal, Naomi

    The notion that women internalize personality characteristics that render them psychologically, socially and intellectually crippled is a denial of experience. The study of sex roles cuts across several disciplines, as well as being the major focus of women's liberation, thus creating the possibility for reappraisal of the field and its…

  2. The Trustee Role in College Personnel Management.

    ERIC Educational Resources Information Center

    Jasiek, Clem R.; And Others

    1985-01-01

    Considers the trustee's role in guaranteeing personnel quality, establishing institutional values, supporting the president in personnel decisions, and defining personnel standards and processes. Reviews the board's powers in personnel management and legislative and regulative considerations. Discusses the impact of an effective evaluation system.…

  3. Role of Zero in Grading. Research Brief

    ERIC Educational Resources Information Center

    Walker, Karen

    2006-01-01

    What is the role of "zero" in grading? According to several authors, giving students a zero lets them too easily off the hook, seldom serves as a motivator for them to do better and is not an accurate reflection of what has been learned. While students do need to be responsible and accountable for their work, assigning a zero skews the grade and…

  4. The Changing Role of the School Principal

    ERIC Educational Resources Information Center

    Ediger, Marlow

    2014-01-01

    The role of the school principal has changed much in the recent intervening years. He/she was formerly thought of as a manager and management of the local school. Today the principal is seen as the leader of curriculum improvement. School principals must believe in pupils being able to achieve optimally in school and in life. Principals must…

  5. Against Apathy: Role Models for Engagement.

    ERIC Educational Resources Information Center

    Loeb, Paul Rogat

    2001-01-01

    Explores how to address the perceptual barriers that dissuade student involvement in social and political issues, including feelings of resignation and helplessness, belief that they must be perfect in their knowledge and confidence before tackling such issues, lack of real knowledge about role models, and a disconnection between smaller,…

  6. The Mass Media Role in Terrorist Campaigns.

    ERIC Educational Resources Information Center

    Moore, Tim; Clavier, David E.

    Terrorists seek recognition for their cause by using violence to create public fear which will force the government into repressive counter-measures. The mass media play a vital role in this strategy. News reports of terrorism may magnify the climate of fear, thereby augmenting the public's overreaction. Moreover, broadcast of terrorist acts may…

  7. The Family's Role in Primary Prevention.

    ERIC Educational Resources Information Center

    Kane, Ruth P.

    1982-01-01

    Defines primary prevention for mental health and explores how the therapeutic process can be patterned after the family developmental life cycle. Examines the family's role in primary prevention and describes anticipatory guidance, support provision, education, and emphasis on strengths as ways of coping. (Author/MJL)

  8. Discrimination, Sex Roles, and Changing Family Structures.

    ERIC Educational Resources Information Center

    Giele, Janet Zollinger

    The problem of discrimination against families within the context of changing sex roles and the growing diversity of family structure is discussed in this paper. It begins with an analysis of underlying social trends, then focuses on sex discrimination and discrimination against different family types and concludes with an interpretation of…

  9. THE ROLE OF APOPTOSIS IN NEUROTOXICOLOGY.

    EPA Science Inventory

    The role of apoptosis in neurodegeneration in developing animals and in adults has become increasingly apparent in the past ten years. Normal apoptosis occurs in the CNS from the embryonic stage through senescence, with different cells in each region of the nervous system having ...

  10. Women's Roles and Vulnerability to Depression.

    ERIC Educational Resources Information Center

    Haussmann, Monika Johanna

    Research has confirmed the prevalence of depression in women, based on theoretical explanations that encompass genetic/endocrinological factors, the learned helplessness model, the cognitive model of depression, the effects of marital and occupational roles, and/or social discrimination. Women (N=215) completed a questionnaire which examined…

  11. Communication Theory's Role in the Reference Interview.

    ERIC Educational Resources Information Center

    Glogoff, Stuart

    1983-01-01

    Notes the applicability of communication science theory to the reference process, particularly in areas involving human behavior, and discusses the roles of both verbal and nonverbal communication (body language, paralanguage, proxemics, and environmental factors) in the reference interview. Forty-one references are provided. (EJS)

  12. Role-Based Design: Design Experiences

    ERIC Educational Resources Information Center

    Miller, Charles; Hokanson, Brad; Doering, Aaron; Brandt, Tom

    2010-01-01

    This is the fourth and final installment in a series of articles presenting a new outlook on the methods of instructional design. These articles examine the nature of the process of instructional design and are meant to stimulate discussion about the roles of designers in the fields of instructional design, the learning sciences, and interaction…

  13. Hold the salt: vasopressor role for BDNF.

    PubMed

    Marosi, Krisztina; Mattson, Mark P

    2015-04-01

    In a recent publication in Neuron, Choe et al. (2015) demonstrate that brain-derived neurotrophic factor (BDNF) signaling mediates salt-induced blood pressure elevation by increasing the excitability of hypothalamic vasopressin-secreting neurons. These findings suggest complex roles for BDNF in adaptive cardiovascular responses to physiological challenges and in the pathogenesis of hypertension. PMID:25863241

  14. Psychology's Role in Mathematics and Science Education

    ERIC Educational Resources Information Center

    Newcombe, Nora S.; Ambady, Nalini; Eccles, Jacquelynne; Gomez, Louis; Klahr, David; Linn, Marcia; Miller, Kevin; Mix, Kelly

    2009-01-01

    Improving mathematics and science education in the United States has been a matter of national concern for over half a century. Psychology has a vital role to play in this enterprise. In this article, the authors review the kinds of contributions that psychology can make in four areas: (a) early understanding of mathematics, (b) understanding of…

  15. The Role of Prelinguistic Vocalizations in Infancy.

    ERIC Educational Resources Information Center

    Ramey, Craig T.

    This paper deals with three areas concerning early vocal development: (1) review and critique of existing experimental evidence suggesting that early vocal behavior has the properties of an operant response, (2) speculations concerning the role of non-verbal vocal behavior in early psychological development, and (3) suggestions for future…

  16. Special and Compensatory Programs: The Administrator's Role.

    ERIC Educational Resources Information Center

    Boschee, Floyd; Beyer, Bonnie M.; Engelking, Jeri L.; Boschee, Marlys Ann

    This textbook provides a comprehensive look at the vast knowledge base supporting special and compensatory education. Each chapter begins with a context and concludes with a section on the school administrator's role in promoting and leading others in each of the special and compensatory programs. Chapters include: (1) "Special Education," which…

  17. The Maturing Mayoral Role in Education

    ERIC Educational Resources Information Center

    Kirst, Michael W.; Edelstein, Fritz

    2006-01-01

    As the chief elected officials of their cities, mayors have a rightful role in promoting the interests of public school students and parents who live there, as well as the interests of taxpayers who help fund the school district. Without a strong education system, mayors will find it more difficult to recruit new businesses, strengthen economic…

  18. Geriatrix: A Role-Playing Game.

    ERIC Educational Resources Information Center

    Hoffman, Stephanie B.; And Others

    1985-01-01

    To sensitize medical students to the complexities of geriatric patient care, the geriatrics faculty of Upstate Medical Center's Clinical Campus developed Geriatrix, a role-playing game. Students attempt to win points in a board game containing Fact, Concept, and Crisis Squares. Crises promote exposure to ethical dilemmas and invite intense debate…

  19. Reinvigorating the role of science in democracy.

    PubMed

    Rosenberg, Andrew A; Halpern, Michael; Shulman, Seth; Wexler, Celia; Phartiyal, Pallavi

    2013-01-01

    Private and political interests routinely conspire to sideline and misrepresent science and evidence in the public policy process. The Center for Science and Democracy, a new initiative at the Union of Concerned Scientists, endeavors to change this dynamic to strengthen the role of science in decision making. PMID:23667322

  20. The Role of Touch in Facilitated Communication.

    ERIC Educational Resources Information Center

    Kezuka, Emiko

    1997-01-01

    A study investigated the role of touch in the use of facilitated communication with Japanese individuals with autism. Five experiments were conducted involving a "telepathy game" using a rod with an attached strain gauge. Results found the facilitator's contact controlled the motor responses of the subjects. (Author/CR)

  1. The Principal's Role in Reporting Child Abuse.

    ERIC Educational Resources Information Center

    Payne, Beth

    1991-01-01

    The role of the principal in identifying and reporting child abuse and neglect is discussed in this bulletin. Although all 50 states and the District of Columbia have laws that require educators to report cases in which they have knowledge or reasonable cause to suspect child abuse, passage of legislation does not always lead to compliance.…

  2. Provider Role Attitudes, Marital Satisfaction, Role Overload, and Housework: A Dyadic Approach

    PubMed Central

    Helms, Heather M.; Walls, Jill K.; Crouter, Ann C.; McHale, Susan M.

    2010-01-01

    Treating the marital dyad as the unit of analysis, this study examined the within-couple patterning of 272 dual-earner spouses’ provider role attitudes and their longitudinal associations with marital satisfaction, role overload, and the division of housework. Based on the congruence of husbands’ and wives’ provider role attitudes, couples were classified into one of four types: (1) main-secondary, (2) coprovider, (3) ambivalent coprovider, and (4) mismatched couples. Nearly half of all spouses differed in their attitudes about breadwinning. A series of mixed model ANCOVAs revealed significant between- and within-couple differences in human capital characteristics, spouses’ perceptions of marital satisfaction and role overload, and the division of housework across 3 years of measurement. Coprovider couples reported higher levels of marital satisfaction and a more equitable division of housework than the other couple groups. Wives in the ambivalent coprovider couples’ group reported higher levels of role overload than their husbands to a greater extent than was found in the other couple groups. As the first study to adopt a dyadic approach that considers the meanings that both spouses in dual-earner couples ascribe to paid employment, these findings advance understanding of how dual-earner spouses’ provider role attitudes serve as contexts for marital quality, behavior, and role-related stress. PMID:20954767

  3. Role Management Strategies of Beginning Teachers in Hong Kong

    ERIC Educational Resources Information Center

    Choi, Pik Lin; Tang, Sylvia Yee Fan

    2005-01-01

    Beginning teachers encounter new challenges as the role system in contemporary society has become more and more demanding. By means of the life history method, role management strategies of four Hong Kong beginning teachers employed to cope with role demands and intra-role conflicts were located in their biographical, workplace and wider…

  4. Role Models and Psychosocial Outcomes among African American Adolescents.

    ERIC Educational Resources Information Center

    Bryant, Alison L.; Zimmerman, Marc A.

    2003-01-01

    Examined relationship of role models among African American ninth-graders to substance use, delinquency, academic engagement, and psychological well-being. Found that males without male role models and females identifying brothers as role models reported the most problem behavior. Adolescents with paternal role models had most positive school…

  5. Preschool Children's Attitudes about Deviations from Gender-Role Behaviors.

    ERIC Educational Resources Information Center

    Blakemore, Judith E. Owen; Russ, Lisa S.

    This study examined 3- to 7-year old children's knowledge about gender roles and moral and social norms, their beliefs about the possibility of violating these roles and norms, and their attitudes about children who do. The gender role norms were grouped into several categories: toys, games, play styles, adult occupations, adult parental roles,…

  6. Reality and Second-Language Role-Play.

    ERIC Educational Resources Information Center

    Piper, David; Piper, Terry

    1983-01-01

    Although role playing is a well-established and useful method of second language instruction, its success is often undermined by assignment of roles alien to the students' needs and experience. Redefinition of role playing to include the roles an individual assumes in everyday life will help the teacher plan more appropriate activities. (MSE)

  7. The Managerial Roles of Community College Chief Academic Officers.

    ERIC Educational Resources Information Center

    Anderson, Philip Wayne

    This study utilized Mintzberg's taxonomy of managerial roles to examine the roles performed by community college chief academic officers (CAOs). Mintzberg's taxonomy defines managerial roles as a set of behaviors and identifies 10 distinct roles: (1) figurehead; (2) leader; (3) liaison; (4) monitor; (5) disseminator; (6) spokesperson; (7)…

  8. 44 CFR 80.5 - Roles and responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Roles and responsibilities... ACQUISITION AND RELOCATION FOR OPEN SPACE General § 80.5 Roles and responsibilities. The roles and... this section. These are in addition to grants management roles and responsibilities identified...

  9. 44 CFR 80.5 - Roles and responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Roles and responsibilities... ACQUISITION AND RELOCATION FOR OPEN SPACE General § 80.5 Roles and responsibilities. The roles and... this section. These are in addition to grants management roles and responsibilities identified...

  10. Instructional Coach Job Satisfaction: An Exploration of Role Stressors

    ERIC Educational Resources Information Center

    Debacker, Jeffrey Paul

    2013-01-01

    This mixed methods dissertation examines the relationships between role conflict and job satisfaction, role ambiguity and job satisfaction, and role conflict and job satisfaction within a convenience sample of American instructional coaches (n = 46). Theoretically, this analysis is formed by Merton's idea of role-sets and how instructional…

  11. Role Change (From Teacher to Teacher/Advisor).

    ERIC Educational Resources Information Center

    Aiken, James B.

    Cognitive and operational difficulties that may ensue from the modification of teacher role into teacher/advisor role can be alleviated by the adoption of four sequential processes. Teachers and administrators involved in role change must pass through the stages of: (1) modifying the old role to include the new; (2) identifying with the new role…

  12. A Role Analysis of Department Chairmen at State Universities.

    ERIC Educational Resources Information Center

    Montgomery, James R.; And Others

    This study suggests that the position of department chairman can be viewed from two perspectives: the roles required of the position and the preparation of faculty for these roles. A taxonomy of the major roles of chairmen was provided. Investigation of chairmen's activities in their academic, administrative, and leadership roles permits a better…

  13. Parents or Pop Culture? Children's Heroes and Role Models.

    ERIC Educational Resources Information Center

    Anderson, Kristin J.; Cavallaro, Donna

    2002-01-01

    Examines the impact of mass media on children's choices of heroes and role models. Addresses questions of which cultural messages children attend to, whether role models vary according to ethnicity and gender, and the role played by educators in exposing children to previously unconsidered role models. (DLH)

  14. Testing Belbin's Team Role Theory of Effective Groups.

    ERIC Educational Resources Information Center

    Prichard, Jane S.; Stanton, Neville A.

    1999-01-01

    Belbin's theory that teams with a wide range of roles are more effective than those with role imbalance was tested with six teams composed of individuals with homogenous roles and six with mixed roles. Mixed teams performed better on team tasks. (SK)

  15. Choices & Careers; Free to Choose: Traditional Roles. With Leaders Guide.

    ERIC Educational Resources Information Center

    Dodge, Carol J.

    Focusing on a comparison of actual roles with stereotypical roles of tribal women, this unit emphasizes the fact that roles of Indian women of the past were dependent upon tribal customs and living conditions. The narrative section of the unit examines typical roles in Woodland tribes and describes the false information and stereotypes which…

  16. Androgens in pregnancy: roles in parturition

    PubMed Central

    Makieva, Sofia; Saunders, Philippa T.K.; Norman, Jane E.

    2014-01-01

    BACKGROUND Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterus (i) retains the fetus in utero during pregnancy without initiating stretch-induced contractions and (ii) is able to dilate the cervix and contract the myometrium at term to deliver the fetus. The onset of labour is associated with successful cervical remodelling and contraction of myometrium, arising from concomitant activation of uterine immune and endocrine systems. A large body of evidence suggests that actions of local steroid hormones may drive changes occurring in the uterine microenvironment at term. Although there have been a number of studies considering the potential role(s) played by progesterone and estrogen at the time of parturition, the bio-availability and effects of androgens during pregnancy have received less scrutiny. The aim of this review is to highlight potential roles of androgens in the biology of pregnancy and parturition. METHODS A review of published literature was performed to address (i) androgen concentrations, including biosynthesis and clearance, in maternal and fetal compartments throughout gestation, (ii) associations of androgen concentrations with adverse pregnancy outcomes, (iii) the role of androgens in the physiology of cervical remodelling and finally (iv) the role of androgens in the physiology of myometrial function including any impact on contractility. RESULTS Some, but not all, androgens increase throughout gestation in maternal circulation. The effects of this increase are not fully understood; however, evidence suggests that increased androgens might regulate key processes during pregnancy and parturition. For example, androgens are believed to be critical for cervical remodelling at term, in particular cervical ripening, via regulation of cervical collagen fibril organization. Additionally, a number of studies highlight

  17. Possible intermediary role of ghrelin in seborrhea.

    PubMed

    Elham, Zareie; Shahram, Agah; Omid, Sadeghpour

    2015-12-01

    Seborrhea, or oily skin, is a very common condition, especially among young people, caused by the increased secretion of sebum by sebaceous glands in the skin. Based on today's knowledge, a regulatory role of various hormones especially androgens is considered for sebaceous gland secretion; but despite significant evidences emphasis on the effects of the gastrointestinal disorders on coetaneous manifestations, the role of gastrointestinal problems in sebum secretion has not been emphasized yet. This study aimed to explain hormonal changes occurring in gastroesophageal reflux disease which may cause changes in sebaceous gland secretion so that, by explaining these communication mechanisms, common investigations between gastroenterology and dermatology can be performed to evaluate the accuracy of this hypothesis. PMID:26342835

  18. Physics And Its Roles In Economic Development

    NASA Astrophysics Data System (ADS)

    Melville, Peter

    2007-04-01

    Physics plays a variety of roles in economic development. These are explored and ways of increasing the importance of physics to world economies are discussed. Surveys by the Institute of Physics have shown that over 40% of employment in manufacturing in the UK is based on physics, and that this sector continues to expand. Physics provides techniques and equipment for advances in the life sciences. An education in physics gives an ability to tackle a diverse range of subjects from first principles and to find innovative solutions to problems where conventional approaches fail. Physicists in many countries readily find employment in a wide range of areas. However, because of the range of opportunities available, there is a reluctance of physics graduates to enter teaching and prepare the next generation of physicists. Sharing experience between countries is vital. The World Year of Physics has played an important role in this.

  19. Potential role of sirtuins in livestock production.

    PubMed

    Ghinis-Hozumi, Y; Antaramian, A; Villarroya, F; Piña, E; Mora, O

    2013-01-01

    Sirtuins are NAD(+)-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate energy homeostasis as they can sense the metabolic state of the cell through the NAD(+)/NADH ratio; hence, changes in the diet can modify the expression of these enzymes. Dietary manipulations are a common practice currently being used in livestock production with favorable results, probably due in part to the enhanced activity of sirtuins. Nevertheless, sirtuin expression in livestock species has not been a research target. For these reasons, the goal of this review is to awaken interest in these enzymes for future detailed characterization in livestock species by presenting a general introduction to what sirtuins are, how they work and what is known about their role in livestock. PMID:23031219

  20. The role of ubiquitin in retroviral egress.

    PubMed

    Martin-Serrano, Juan

    2007-10-01

    HIV and many other enveloped viruses encode a late budding domain (L-domain) that recruits the cellular machinery that mediates the separation of the nascent virion from the infected cell. The ubiquitin-proteasome system has been implicated in the L-domain activity, but the exact role of ubiquitin transfer and ubiquitin-binding proteins in the last step of viral replication remains elusive. It is now widely accepted that the class E vacuolar protein sorting pathway mediates both viral budding and vesicle budding into the multivesicular bodies and, remarkably, both budding events share the same topology and similar requirements for ubiquitin. In this review, the role of ubiquitin in viral budding is discussed in the light of recent advances in the understanding of the cellular mechanisms that assist the last step of HIV-1 release. PMID:17645437

  1. Role of sebaceous glands in inflammatory dermatoses.

    PubMed

    Shi, Vivian Y; Leo, Michael; Hassoun, Lauren; Chahal, Dev S; Maibach, Howard I; Sivamani, Raja K

    2015-11-01

    Skin is an important interface between the host and its environment. Inflammatory dermatoses often have disrupted skin barrier function, rendering patients more susceptible to allergenic triggers leading to an exaggerated immune response. The skin surface lipid film, an important component of the skin barrier, comprises a mixture of keratinocyte and sebaceous gland-derived lipids. Recent evidence demonstrated that defective keratinocyte lipid synthesis predisposes for the development of atopic dermatitis. However, the important role of sebaceous gland-derived lipids in skin inflammatory diseases may be underrecognized. This overview focuses on the importance of the contribution of sebaceous glands to barrier function. Sebaceous gland alteration may play a role in the pathogenesis of common skin diseases including acne vulgaris, atopic dermatitis, psoriasis, rosacea, and seborrheic dermatitis. PMID:26386632

  2. Restoring Psychology's Role in Peptic Ulcer

    PubMed Central

    Overmier, J Bruce; Murison, Robert

    2013-01-01

    This paper reviews the history of the transition from the belief that gastrointestinal ulcers are caused primarily by psychological factors to the current state of belief that they are caused primarily by infection and argues that neither is fully accurate. We argue that psychological factors play a significant role as predisposing to vulnerability, modulating of precipitation, and sustaining of gastric ulceration. We review data that challenge the assumption of a simple infectious disease model and adduce recent preclinical data that confirm the predisposing, modulatory, and sustaining roles for psychological factors. We note that others, too, are now challenging the adequacy of the contemporary simple bacterial infection model. We hope to replace the competition between psychology and medicine with cooperation in understanding and treating patients suffering gastric ulceration and ulcer. PMID:23457084

  3. The Greening Role of Tour Operators

    NASA Astrophysics Data System (ADS)

    Lozano, Javier; Arbulú, Italo; Rey-Maquieira, Javier

    2016-01-01

    This paper shows that the tour operators (TOs) can play a coordinating role in the adoption of environmental management upstream the tourism supply chain. This is done using a dynamic model to analyze the environmental management adoption by hotels in a tourism destination induced by a TO. The TO can create incentives to greening hotels' management through the sharing of an environmental price premium. We show that the extent of green management adoption depends on interest rate, the willingness to pay for environmental quality, and hotels' organizational inertia. We also show how the financial yields from green management are shared between TOs and hotels. Finally, we consider a destination manager that subsidizes hotels' green management. If the destination manager does not take the greening role of TOs into account, she could mistake the true trade-off that she faces between the destination's economic and environmental outcomes for the win-win setting that characterizes the general problem.

  4. The Greening Role of Tour Operators.

    PubMed

    Lozano, Javier; Arbulú, Italo; Rey-Maquieira, Javier

    2016-01-01

    This paper shows that the tour operators (TOs) can play a coordinating role in the adoption of environmental management upstream the tourism supply chain. This is done using a dynamic model to analyze the environmental management adoption by hotels in a tourism destination induced by a TO. The TO can create incentives to greening hotels' management through the sharing of an environmental price premium. We show that the extent of green management adoption depends on interest rate, the willingness to pay for environmental quality, and hotels' organizational inertia. We also show how the financial yields from green management are shared between TOs and hotels. Finally, we consider a destination manager that subsidizes hotels' green management. If the destination manager does not take the greening role of TOs into account, she could mistake the true trade-off that she faces between the destination's economic and environmental outcomes for the win-win setting that characterizes the general problem. PMID:26253501

  5. Unraveling the role of Mg(++) in osteoarthritis.

    PubMed

    Li, Yaqiang; Yue, Jiaji; Yang, Chunxi

    2016-02-15

    Mg(++) is widely involved in human physiological processes that may play key roles in the generation and progression of diseases. Osteoarthritis (OA) is a complex joint disorder characterized by articular cartilage degradation, abnormal mineralization and inflammation. Magnesium deficiency is considered to be a major risk factor for OA development and progression. Magnesium deficiency is active in several pathways that have been implicated in OA, including increased inflammatory mediators, cartilage damage, defective chondrocyte biosynthesis, aberrant calcification and a weakened effect of analgesics. Abundant in vitro and in vivo evidence in animal models now suggests that the nutritional supplementation or local infiltration of Mg(++) represent effective therapies for OA. The goal of this review is to summarize the current understanding of the role of Mg(++) in OA with particular emphasis on the related molecular mechanisms involved in OA progression. PMID:26800786

  6. The role of vitamin D in malaria.

    PubMed

    Lương, Khanh Vinh Quốc; Nguyễn, Lan Thi Hoàng

    2015-01-01

    An abnormal calcium-parathyroid hormone (PTH)-vitamin D axis has been reported in patients with malaria infection. A role for vitamin D in malaria has been suggested by many studies. Genetic studies have identified numerous factors that link vitamin D to malaria, including human leukocyte antigen genes, toll-like receptors, heme oxygenase-1, angiopoietin-2, cytotoxic T lymphocyte antigen-4, nucleotide-binding oligomerization domain-like receptors, and Bcl-2. Vitamin D has also been implicated in malaria via its effects on the Bacillus Calmette-Guerin (BCG) vaccine, matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, reactive oxidative species, and nitric oxide synthase. Vitamin D may be important in malaria; therefore, additional research on its role in malaria is needed. PMID:25596566

  7. Multiple Roles of Peroxiredoxins in Inflammation

    PubMed Central

    Knoops, Bernard; Argyropoulou, Vasiliki; Becker, Sarah; Ferté, Laura; Kuznetsova, Oksana

    2016-01-01

    Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets. PMID:26813661

  8. Emerging role of thyroid hormone metabolites.

    PubMed

    Gnocchi, D; Steffensen, K R; Bruscalupi, G; Parini, P

    2016-07-01

    Thyroid hormones (THs) are essential for the regulation of development and metabolism in key organs. THs produce biological effects both by directly affecting gene expression through the interaction with nuclear receptors (genomic effects) and by activating protein kinases and/or ion channels (short-term effects). Such activations can be either direct, in the case of ion channels, or mediated by membrane or cytoplasmic receptors. Short-term-activated signalling pathways often play a role in the regulation of genomic effects. Several TH intermediate metabolites, which were previously considered without biological activity, have now been associated with a broad range of actions, mostly attributable to short-term effects. Here, we give an overview of the physiological roles and mechanisms of action of THs, focusing on the emerging position that TH metabolites are acquiring as important regulators of physiology and metabolism. PMID:26748938

  9. The Role of Calcium Channels in Epilepsy.

    PubMed

    Rajakulendran, Sanjeev; Hanna, Michael G

    2016-01-01

    A central theme in the quest to unravel the genetic basis of epilepsy has been the effort to elucidate the roles played by inherited defects in ion channels. The ubiquitous expression of voltage-gated calcium channels (VGCCs) throughout the central nervous system (CNS), along with their involvement in fundamental processes, such as neuronal excitability and synaptic transmission, has made them attractive candidates. Recent insights provided by the identification of mutations in the P/Q-type calcium channel in humans and rodents with epilepsy and the finding of thalamic T-type calcium channel dysfunction in the absence of seizures have raised expectations of a causal role of calcium channels in the polygenic inheritance of idiopathic epilepsy. In this review, we consider how genetic variation in neuronal VGCCs may influence the development of epilepsy. PMID:26729757

  10. Role of autophagy in chronic kidney diseases

    PubMed Central

    Mao, Song; Zhang, Jianhua

    2015-01-01

    Chronic kidney diseases (CKD), a common pathway of various glomerular diseases, which carries great morbidity and mortality to people. CKD is characterized by progressive kidney fibrosis and remodeling. CKD is also associated with the depletion of glomerular and tubular cells. Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. It plays an important role in both normal and disease states, including immunity, inflammation, and adaptation to stress. Evidence has indicated that impaired autophagic activity is involved in the development of CKD. Here, we review the progress in our understanding of the role of autophagy in the development and progression of CKD. Targeting the autophagic signaling pathways may be a therapeutic strategy for CKD. PMID:26885176

  11. Role of Glycosaminoglycans in Infectious Disease

    PubMed Central

    Jinno, Akiko; Park, Pyong Woo

    2015-01-01

    Glycosaminoglycans (GAGs) have been shown to bind to a wide variety of microbial pathogens, including viruses, bacteria, parasites, and fungi in vitro. GAGs are thought to promote pathogenesis by facilitating pathogen attachment, invasion, or evasion of host defense mechanisms. However, the role of GAGs in infectious disease has not been extensively studied in vivo and therefore their pathophysiological significance and functions are largely unknown. Here we describe methods to directly investigate the role of GAGs in infections in vivo using mouse models of bacterial lung and corneal infection. The overall experimental strategy is to establish the importance and specificity of GAGs, define the essential structural features of GAGs, and identify a biological activity of GAGs that promotes pathogenesis. PMID:25325982

  12. The roles of macrophage autophagy in atherosclerosis

    PubMed Central

    Shao, Bo-zong; Han, Bin-ze; Zeng, Yan-xia; Su, Ding-feng; Liu, Chong

    2016-01-01

    Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts suggest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis. PMID:26750103

  13. An autonomous role in emergency departments.

    PubMed

    Swann, Garry; Chessum, Peter; Fisher, Joanne; Cooke, Matthew

    2013-06-01

    Heart of England NHS Foundation Trust, which manages 250,000 patients in three emergency units each year, has created an advanced clinical practitioner (ACP) role to ensure that patients can be seen in a timely manner as demand for emergency services continues to rise. Advanced clinical practitioners are non-medical clinicians who eventually work autonomously at the level of middle-grade doctors and manage patients with all types of clinical presentations in the emergency department (ED). This article provides an overview of the development and benefits of the ACP role and outlines the phases of a programme for staff who wish to achieve senior clinician status in the ED. PMID:23888560

  14. The mediating role of facebook fan pages.

    PubMed

    Chih, Wen-Hai; Hsu, Li-Chun; Wang, Kai-Yu; Lin, Kuan-Yu

    2014-01-01

    Using the dual mediation hypothesis, this study investigates the role of interestingness (the power of attracting or holding one's attention) attitude towards the news, in the formation of Facebook Fan Page users' electronic word-of-mouth intentions. A total of 599 Facebook fan page users in Taiwan were recruited and structural equation modeling (SEM) was used to test the research hypotheses. The results show that both perceived news entertainment and informativeness positively influence interestingness attitude towards the news. Interestingness attitude towards the news subsequently influences hedonism and utilitarianism attitudes towards the Fan Page, which then influence eWOM intentions. Interestingness attitude towards the news plays a more important role than hedonism and utilitarianism attitudes in generating electronic word-of-mouth intentions. Based on the findings, the implications and future research suggestions are provided. PMID:24875695

  15. [Roles of Aquaporins in Brain Disorders].

    PubMed

    Yasui, Masato

    2015-06-01

    Aquaporin (AQP) is a water channel protein that is expressed in the cell membranes. AQPs are related to several kinds of human diseases such as cataract. In the mammalian central nervous system (CNS), AQP4 is specifically expressed in the astrocyte membranes lining the perivascular and periventricular structures. AQP4 plays a role in the development of brain edema associated with certain brain disorders. Neuromyelitis optica (NMO) is a demyelinating disorder, and patients with NMO develop autoimmune antibodies against AQP4 in their serum. Therefore, AQP4 is involved in NMO pathogenesis. A new concept referred to as "glymphatic pathway" has been recently proposed to explain the lymphatic system in the CNS. Dysfunction of the "glymphatic pathway" may cause several neurodegenerative diseases and mood disorders. Importantly, AQP4 may play a role in the "glymphatic pathway". Further investigation of AQP4 in CNS disorders is necessary, and a new drug against AQP4 is expected. PMID:26062588

  16. Expanding the role of the oncology nurse

    PubMed Central

    Quinn, A

    2008-01-01

    Oncology nursing continues to evolve in response to advances in cancer treatment, information and biotechnology. As new scientific and technological discoveries are integrated into cancer care, oncology nurses need to play a key role in the management of this patient population. The role of the oncology nurse has expanded significantly and can differ greatly across cultures. Sophisticated treatments and the growth of targeted therapies will create the challenge of ensuring that all nurses working in this arena are well-educated, independent thinkers. Thus the future success of oncology nurses will focus on enhancement of nursing practice through advanced education. The increased globalisation of healthcare offers exciting opportunities to accomplish this goal by allowing for collaborative relationships among oncology nurses across the globe. PMID:21611002

  17. Role of Intermediate Filaments in Vesicular Traffic

    PubMed Central

    Margiotta, Azzurra; Bucci, Cecilia

    2016-01-01

    Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway. PMID:27120621

  18. Role of transcranial Doppler in cerebrovascular disease.

    PubMed

    Kulkarni, Amit A; Sharma, Vijay K

    2016-01-01

    Transcranial Doppler (TCD) is the only noninvasive modality for the assessment of real-time cerebral blood flow. It complements various anatomic imaging modalities by providing physiological-flow related information. It is relatively cheap, easily available, and can be performed at the bedside. It has been suggested as an essential component of a comprehensive stroke centre. In addition to its importance in acute cerebrovascular ischemia, its role is expanding in the evaluation of cerebral hemodynamics in various disorders of the brain. The "established" clinical indications for the use of TCD include cerebral ischemia, sickle cell disease, detection of right-to-left shunts, subarachnoid hemorrhage, periprocedural or surgical monitoring, and brain death. We present the role of TCD in acute cerebrovascular ischemia, sonothrombolysis, and intracranial stenosis. PMID:27625245

  19. Extracellular Matrix Revisited: Roles in Tissue Engineering

    PubMed Central

    2016-01-01

    The extracellular matrix (ECM) is a heterogeneous, connective network composed of fibrous glycoproteins that coordinate in vivo to provide the physical scaffolding, mechanical stability, and biochemical cues necessary for tissue morphogenesis and homeostasis. This review highlights some of the recently raised aspects of the roles of the ECM as related to the fields of biophysics and biomedical engineering. Fundamental aspects of focus include the role of the ECM as a basic cellular structure, for novel spontaneous network formation, as an ideal scaffold in tissue engineering, and its essential contribution to cell sheet technology. As these technologies move from the laboratory to clinical practice, they are bound to shape the vast field of tissue engineering for medical transplantations. PMID:27230457

  20. Role of CHK2 in cancer development.

    PubMed

    Perona, Rosario; Moncho-Amor, Verónica; Machado-Pinilla, Rosario; Belda-Iniesta, Cristóbal; Sánchez Pérez, Isabel

    2008-09-01

    DNA repair pathways enable tumour cells to survive DNA damage induced by external agents such as therapeutic treatments. Signalling cascades involved in these pathways comprise the DNA-dependent protein kinase (DNA-PK), Ataxia-telangiectasia mutated (ATM), ATM and Rad3 related (ATR) and checkpoint kinases I and 2 (Chk1/Chk2), among others. ATM and ATR phosphorylate, respectively, Chk2 and Chk1, leading to activation of checkpoints. Chk2 acts as a signal distributor, dispersing checkpoint signal to downstream targets such as p53, Cdc25A, Cdc25C, BRCA1 and E2F1. A role of Chk2 as a candidate tumour suppressor has been suggested based on both mouse genetics and somatic tumour studies. We will discuss here the possible role of this kinase in human carcinogenesis and the possibility to use it as a target to increment DNA damage in cancer cells in response to DNA-damaging therapies. PMID:18796370

  1. Roles for Growth Factors in Cancer Progression

    PubMed Central

    Witsch, Esther; Sela, Michael; Yarden, Yosef

    2011-01-01

    Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy. PMID:20430953

  2. Family Patterns of Gender Role Attitudes

    PubMed Central

    Marks, Jaime; Bun, Lam Chun; McHale, Susan M.

    2012-01-01

    Study goals were to identify family patterns of gender role attitudes, to examine the conditions under which these patterns emerged, and to assess the implications of gender attitude patterns for family conflict. Participants were mothers, fathers, and first- and second-born adolescents from 358 White, working and middle-class US families. Results of cluster analysis revealed three gender role attitude patterns: egalitarian parents and children, traditional parents and children, and a divergent pattern, with parents more traditional and children more egalitarian. Mixed-model ANOVAs indicated that these family patterns were related to socioeconomic status, parents' time spent in gendered household tasks and with children, and the gender constellation of the sibling dyad. The traditional family group reported the most family conflict. PMID:22308059

  3. Roles of Hydrogen in Space Explorations

    NASA Astrophysics Data System (ADS)

    Bowman, Robert C.

    2006-05-01

    The various roles of hydrogen in space technology are identified and discussed. The preeminent position of hydrogen as rocket fuel in launch vehicles is explained and illustrated for the NASA Space Shuttle. The history of hydrogen in launching space vehicles is also briefly summarized. The cryogenic aspects of hydrogen for cooling instruments during flight missions are covered for several past and current systems. The technology of Nickel-Hydrogen batteries is covered. The storage of cryogenic hydrogen to operate fuel cells and to provide potable water is described for the NASA Apollo and Shuttle Missions. Other less well-known applications of hydrogen and metal hydrides such as gas gap heat switches, fueling hypersonic scramjet flights to Mach 10 speeds, in-situ resource utilization on lunar or Martian surfaces, and providing ultrapure reference hydrogen to scientific instruments are also described. Finally, some possible future roles for hydrogen in space exploration are identified.

  4. [Roles of NLRP1 in blood diseases].

    PubMed

    Wu, Jin-Yan; Zeng, Ling-Yu

    2014-10-01

    The inflammasome is a group of multiprotein complexes in the cytoplasm, which can activate caspase-1 that mediates the maturation and release of IL-1β, IL-18, IL-33 and other pro-inflammatory cytokines.NALP1 (NACHT leucine-rich-repeat protein 1), also known as NLRP1, is the first one of the identified complex inflammasomes with definite ligands mainly involved in the activation of inflammasome assembly and the formation of apoptotic bodies. Moreover, it was also found that NLRP1 plays an important biological role in the development of acute leukemia, the bone marrow hematopoietic stem cell apoptosis and other blood diseases. This review briefly summarizes the structure, activation mechanism, regulation and the role of NLRP1 in the hematopoietic system. PMID:25338611

  5. Role of phospholipases in adrenal steroidogenesis.

    PubMed

    Bollag, Wendy B

    2016-04-01

    Phospholipases are lipid-metabolizing enzymes that hydrolyze phospholipids. In some cases, their activity results in remodeling of lipids and/or allows the synthesis of other lipids. In other cases, however, and of interest to the topic of adrenal steroidogenesis, phospholipases produce second messengers that modify the function of a cell. In this review, the enzymatic reactions, products, and effectors of three phospholipases, phospholipase C, phospholipase D, and phospholipase A2, are discussed. Although much data have been obtained concerning the role of phospholipases C and D in regulating adrenal steroid hormone production, there are still many gaps in our knowledge. Furthermore, little is known about the involvement of phospholipase A2, perhaps, in part, because this enzyme comprises a large family of related enzymes that are differentially regulated and with different functions. This review presents the evidence supporting the role of each of these phospholipases in steroidogenesis in the adrenal cortex. PMID:26878860

  6. Multiple roles of graphene in heterogeneous catalysis.

    PubMed

    Fan, Xiaobin; Zhang, Guoliang; Zhang, Fengbao

    2015-05-21

    Scientific interest in graphene as a catalyst and as a catalyst support in heterogeneous catalytic reactions has grown dramatically over the past several years. The present critical review summarizes the multiple roles of graphene in heterogeneous catalysis and highlights the influence of defects, heteroatom-containing functionalities, and graphene's two-dimensional structure on catalytic performance. We first discuss the role and advantages of graphene as a catalyst support, with emphasis on its interactions with the catalytic phases and the influence of mass transfer processes. We then clarify the origin of the intrinsic catalytic activity of graphene in heterogeneous catalytic reactions. Finally we suggest challenges and potential practical applications for graphene in industrial processes. PMID:25777748

  7. The Roles of Acidosis in Osteoclast Biology

    PubMed Central

    Yuan, Feng-Lai; Xu, Ming-Hui; Li, Xia; Xinlong, He; Fang, Wei; Dong, Jian

    2016-01-01

    The adverse effect of acidosis on the skeletal system has been recognized for almost a century. Although the underlying mechanism has not been fully elucidated, it appears that acidosis acts as a general stimulator of osteoclasts derived from bone marrow precursors cells and enhances osteoclastic resorption. Prior work suggests that acidosis plays a significant role in osteoclasts formation and activation via up-regulating various genes responsible for its adhesion, migration, survival and bone matrix degradation. Understanding the role of acidosis in osteoclast biology may lead to development of novel therapeutic approaches for the treatment of diseases related to low bone mass. In this review, we aim to discuss the recent investigations into the effects of acidosis in osteoclast biology and the acid-sensing molecular mechanism. PMID:27445831

  8. The role of serendipity in drug discovery

    PubMed Central

    Ban, Thomas A.

    2006-01-01

    Serendipity is one of the many factors that may contribute to drug discovery. It has played a role in the discovery of prototype psychotropic drugs that led to modern pharmacological treatment in psychiatry. It has also played a role in the discovery of several drugs that have had an impact on the development of psychiatry, “Serendipity” in drug discovery implies the finding of one thing while looking for something else. This was the case in six of the twelve serendipitous discoveries reviewed in this paper, ie, aniline purple, penicillin, lysergic acid diethylamide, meprobamate, chlorpromazine, and imipramine, in the case of three drugs, ie, potassium bromide, chloral hydrate, and lithium, the discovery was serendipitous because an utterly false rationale led to correct empirical results; and in case of two others, ie, iproniazid and sildenafil, because valuable indications were found for these drugs which were not initially those sought. The discovery of one of the twelve drugs, chlordiazepoxide, was sheer luck. PMID:17117615

  9. Euthanasia: American attitudes toward the physician's role.

    PubMed

    Caddell, D P; Newton, R R

    1995-06-01

    This is a study of American public opinion toward euthanasia and the physician's role in performing it. The authors examine how these attributes are affected by religious affiliation, religious self-perception, political self-perception and education. The data include 8384 American respondents from years 1977, 1978, 1982, 1985 and 1988 of the General Social Survey conducted by the National Opinion Research Center. The findings suggest that highly educated, politically liberal respondents with a less religious self-perception are most likely to accept active euthanasia or suicide in the case of terminally ill patient. The data also show that Americans tend to draw a distinction between the suicide of a terminally ill patient and active euthanasia under the care of a physician, preferring to have the physician perform this role in the dying process. The tendency to see a distinction between active euthanasia and suicide was clearly affected by religious affiliation and education. PMID:7660180

  10. Mitophagy: mechanisms, pathophysiological roles, and analysis

    PubMed Central

    Ding, Wen-Xing; Yin, Xiao-Ming

    2013-01-01

    Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy. PMID:22944659

  11. The Role of PGRN in Alzheimer's Disease.

    PubMed

    Jing, Hua; Tan, Meng-Shan; Yu, Jin-Tai; Tan, Lan

    2016-08-01

    Progranulin (PGRN), a multifunctional growth factor expressed in various tissues, is involved in a diversity of physiologic and pathological processes, including cell proliferation, wound healing, and modulation of inflammation. Interest in the role of progranulin in the brain has increased dramatically since mutations in GRN, which encodes for the protein PGRN, are associated with the pathogenesis of Alzheimer's disease (AD). A great many of studies suggest that PGRN participates in AD pathogenesis through diverse pathways, including Aβ deposition and clearance, intraneuronal deposition of phosphorylated tau, neuroinflammation, and neuronal survival. Decreased GRN mRNA levels can be detected in the parietal lobe of patients clinically diagnosed with AD; more importantly, emerging data support that serum or plasma PGRN can act as a biomarker for AD. By understanding PGRN in a wider context, we may be better able to depict its role in AD and then provide a therapeutic strategy for AD. PMID:26215834

  12. Role conflict in occupational therapy student parents.

    PubMed

    Menks, F A; Tupper, L C

    1987-01-01

    Surveys were conducted of occupational therapy curricula and of student parents who had a child or children less than 18 years old living with them. This was done to gather demographic data, to assess students' level of involvement in student and professional activities, to examine extent and sources of role conflict and potential support systems, and to identify curricular modifications that might be helpful in attracting and retaining these students. Of 5165 occupational therapy students, 8.2% were identified as being parents of children less than 18 years old who were living with them. The curricula survey indicated a generally positive attitude towards these nontraditional students. Both the curricula respondents and student respondents indicated that additional resources in the areas of financial support, child care, support groups, and flexible part-time enrollment were needed. Students' responses to the 15 role conflict situations revealed many good problem solving skills and adaptations. PMID:3826270

  13. The role of epigenetics in tuberculosis infection.

    PubMed

    Kathirvel, Maruthai; Mahadevan, Subramanian

    2016-04-01

    Epigenetic mechanisms are pivotal in regulating gene expression during cellular response to extracellular stimuli. Bacterial infections have a profound effect on the host epigenome, which triggers susceptibility to diseases. Recent studies suggest that Mycobacterium tuberculosis (Mtb) can alter the host epigenome to modulate the transcriptional machinery and plays a major role in immunomodulation of the host immune response. However, the mechanism of epigenetic alterations during Mtb infection has not yet been fully understood. Thus, Mtb-induced epigenetic changes may affect the host cell by either activation or suppression of key immune genes involved in immune response or pathogen persistence. In this review, we discuss the principles of epigenetics, recent advances in Mtb-induced alterations in the host epigenetic landscape and their role in the host immune response. PMID:27035266

  14. Roles of small RNAs in tumor formation

    PubMed Central

    Di Leva, Gianpiero; Croce, Carlo M.

    2010-01-01

    MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional repressors of gene expression in organisms ranging from plants to humans. A widespread role for miRNAs in diverse molecular processes driving initiation and progression of various tumor types has recently been described. In this review, we discuss the etiology of aberrant expression of miRNAs in human cancers and their role in tumor metastasis, which may define miRNAs as oncogenes or tumor suppressors. Moreover, we highlight the genomic/epigenetic alterations and transcriptional/post-transcriptional mechanisms associated with misexpression of miRNAs in cancer. A better understanding of miRNA biology may ultimately yield further insight into the molecular mechanisms of tumorigenesis and new therapeutic strategies against cancer. PMID:20493775

  15. Role of TNFα in pulmonary pathophysiology

    PubMed Central

    Mukhopadhyay, Srirupa; Hoidal, John R; Mukherjee, Tapan K

    2006-01-01

    Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions, generation of TNFα at high levels leads to the development of inflammatory responses that are hallmarks of many diseases. Of the various pulmonary diseases, TNFα is implicated in asthma, chronic bronchitis (CB), chronic obstructive pulmonary disease (COPD), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In addition to its underlying role in the inflammatory events, there is increasing evidence for involvement of TNFα in the cytotoxicity. Thus, pharmacological agents that can either suppress the production of TNFα or block its biological actions may have potential therapeutic value against a wide variety of diseases. Despite some immunological side effects, anti-TNFα therapeutic strategies represent an important breakthrough in the treatment of inflammatory diseases and may have a role in pulmonary diseases characterized by inflammation and cell death. PMID:17034639

  16. Role of Intermediate Filaments in Vesicular Traffic.

    PubMed

    Margiotta, Azzurra; Bucci, Cecilia

    2016-01-01

    Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway. PMID:27120621

  17. The role of interleukin-33 in rhinitis.

    PubMed

    Rogala, Barbara; Glück, Joanna

    2013-04-01

    IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine is considered to play a crucial role in an allergic inflammatory disease such as rhinitis. Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed. The role of IL-33 as a novel promising therapeutic target has also been discussed. PMID:23381303

  18. Role of PARP-1 in prostate cancer

    PubMed Central

    Deshmukh, Dhanraj; Qiu, Yun

    2015-01-01

    Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that catalyzes the covalent attachment of polymers of ADP-ribose (PAR) moieties on itself and its target proteins. PARP1 activity is frequently deregulated in various cancers and therefore it has emerged as a new drug target for cancer therapy. The role of PARP-1 in DNA repair has been well documented and BRCA mutations are implicated for determining the sensitivity to PARP inhibitors. Recent studies also point to a role of PARP-1 in transcription regulation which may contribute to oncogenic signaling and cancer progression. Given that efficacy of PARP inhibitors are also seen in patients not harboring BRCA mutations, some other mechanisms might also be involved. In the present review, we highlight the mechanisms by which PARP-1 regulates gene expression in prostate cancer and provide an overview of the ongoing clinical trials using PARP inhibitors in various cancers including prostate cancer. PMID:26069882

  19. Neurotensin: A role in substance use disorder?

    PubMed

    Ferraro, Luca; Tiozzo Fasiolo, Laura; Beggiato, Sarah; Borelli, Andrea C; Pomierny-Chamiolo, Lucyna; Frankowska, Malgorzata; Antonelli, Tiziana; Tomasini, Maria C; Fuxe, Kjell; Filip, Malgorzata

    2016-02-01

    Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin were originally proposed to play a role in the mechanism of action of antipsychotic agents. Additionally, neurotensin-containing pathways were demonstrated to mediate some of the rewarding and/or sensitizing properties of drugs of abuse.This review attempts to contribute to the understanding of the role of neurotensin and its receptors in drug abuse. In particular, we will summarize the potential relevance of neurotensin, its related compounds and neurotensin receptors in substance use disorders, with a focus on the preclinical research. PMID:26755548

  20. The Role of Cardiolipin in Cardiovascular Health.

    PubMed

    Shen, Zheni; Ye, Cunqi; McCain, Keanna; Greenberg, Miriam L

    2015-01-01

    Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health. PMID:26301254

  1. The Role of Cardiolipin in Cardiovascular Health

    PubMed Central

    Shen, Zheni; Ye, Cunqi; McCain, Keanna; Greenberg, Miriam L.

    2015-01-01

    Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health. PMID:26301254

  2. Wikipedia : its reliability and social role

    NASA Astrophysics Data System (ADS)

    Kusaka, Kyuhachi

    This article discusses Japanese Wikipedia's reliability and its social role as a free, collaborative, multilingual Internet encyclopedia supported by the non-profit Wikimedia Foundation. Japanese Wikipedia's reliability is explained from several surveys. The central concern is how the nature of encyclopedia and Wikipedia affects the quality of Wikipedia's articles. Wikipedia's core content policies such as verifiability, no original research and a neutral point of view will make articles better. But incomplete or poorly written first drafts exist because Wikipedia is a work in progress. The article also argues that social role of online encyclopedia which provides knowledge for all. Knowledge-based society or/and advanced information society require public understanding of science and other expertise. Online encyclopedia attributed to a reliable, published source using an inline citation will guide anyone to specialized knowledge.

  3. Helicobacter pylori: a role in schizophrenia?

    PubMed

    Yilmaz, Yusuf; Gul, Cuma Bulent; Arabul, Mahmut; Eren, Mehmet Ali

    2008-07-01

    Schizophrenia is a devastating psychiatric disorder that affects approximately one percent of the world's adult population. Despite substantial investigative efforts over the last decades, the exact mechanisms and pathogenesis of this condition are not yet fully understood. Published data support certain infectious agents as potential risk factors for schizophrenia. Since its discovery, Helicobacter pylori has been implicated in a variety of extra-digestive diseases, but its potential role in the pathogenesis of psychiatric disorders has thus far been neglected. It is hypothesized here that infection with H. pylori occurring in early childhood may induce persisting systemic biochemical aberrations, including dopaminergic dysfunction, decreased levels of essential polyunsaturated fatty acids, subtle inflammation, and homocysteine alterations, that may play a crucial role in the development of schizophrenia in genetically predisposed individuals. Evidence in favor of this hypothesis is provided and possible therapeutic implications are discussed. PMID:18591925

  4. Role of Wnt signaling in fracture healing

    PubMed Central

    Xu, Huiyun; Duan, Jing; Ning, Dandan; Li, Jingbao; Liu, Ruofei; Yang, Ruixin; Jiang, Jean X.; Shang, Peng

    2014-01-01

    The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair. [BMB Reports 2014; 47(12): 666-672] PMID:25301020

  5. [Role of antithrombin iii in cardiac surgery].

    PubMed

    Muedra, V; Barettino, D; D'Ocón, P

    2013-11-01

    Coagulation of blood is of multidisciplinary interest. Cardiac surgery produces major changes in the delicate balance between pro-and anti-coagulant serum factors. The role of antithrombin iii has been analysed after finding evidence that associated decreased levels of protein activity to postoperative morbidity and mortality. Supplementing exogenous antithrombin is considered with the aim of optimising outcomes. Its intrinsic anticoagulant and anti-inflammatory properties have stimulated a growing interest, and suggests new lines of research. PMID:23228672

  6. Role of inflammation in developmental odontogenic pathosis

    PubMed Central

    Gupta, Sandeep S; Shetty, Devi C; Urs, Aadithya B; Nainani, P

    2016-01-01

    Periapical infection in the primary tooth may lead to periapical abscess, granuloma, radicular cyst and even osteomyelitis. The infection in primary teeth can also affect the developing successor teeth leading to hypomineralization, hypoplasia, arrest of tooth development, regional odontodysplasia, delayed eruption etc. The purpose of this article is to report a case of malformed permanent tooth in relation to overlying infected deciduous teeth. The probable role of inflammation in pathogenesis of the present condition is also being discussed. PMID:27194886

  7. The role of human factors in telehealth.

    PubMed

    Demiris, George; Charness, Neil; Krupinski, Elizabeth; Ben-Arieh, David; Washington, Karla; Wu, John; Farberow, Bonne

    2010-05-01

    The purpose of this article is to provide an overview of the field of human factors (HFs) and its role in telehealth. We discuss HF concepts and methodologies that affect the design, implementation, and evaluation of telehealth applications and provide examples from numerous application areas that highlight the significance of HF principles and methodologies. We also provide recommendations for inclusion of HFs in telehealth system design and evaluation, and discuss resulting implications for system designers, practitioners, vendors, and policy makers. PMID:20420540

  8. Role of inflammation in developmental odontogenic pathosis.

    PubMed

    Gupta, Sandeep S; Shetty, Devi C; Urs, Aadithya B; Nainani, P

    2016-01-01

    Periapical infection in the primary tooth may lead to periapical abscess, granuloma, radicular cyst and even osteomyelitis. The infection in primary teeth can also affect the developing successor teeth leading to hypomineralization, hypoplasia, arrest of tooth development, regional odontodysplasia, delayed eruption etc. The purpose of this article is to report a case of malformed permanent tooth in relation to overlying infected deciduous teeth. The probable role of inflammation in pathogenesis of the present condition is also being discussed. PMID:27194886

  9. Role Preparation of Associate Degree Graduates.

    ERIC Educational Resources Information Center

    Stokes, Lillian G.

    The role of associate degree nursing (ADN) programs has changed dramatically in their 30 years of existence. The number of ADN graduates increased from 260 in 1954 to 36,434 in 1980, and 47.8% of all nursing graduates in 1980 came from ADN programs, as compared to 0.9% in 1954. These graduates have the best record of employment five years after…

  10. Aviation's role in earth resources surveys

    NASA Technical Reports Server (NTRS)

    Syvertson, C. A.; Mulholland, D. R.

    1972-01-01

    The role of satellites designed to make a wide variety of earth observations is discussed along with the renewed interest in the use of aircraft as platforms for similar and complementary earth resources surveys. Surveys covering the areas of forestry, agriculture, hydrology, oceanography, geology, and geography are included. Aerials surveys equipped for nonphotographic remote sensing and aircraft flights synchronized with satellite observations to provide correlated data are discussed. Photographs are shown to illustrate preliminary results from several of the test sites.

  11. Enhancing the role of the dairy vet.

    PubMed

    2016-09-01

    More than 3000 veterinarians, researchers and industry representatives gathered in Dublin in July for the 29th congress of the World Association for Buiatrics. With the theme of 'Cattle health - tomorrow's thinking today', the programme for the five-day meeting was wide-ranging, exploring issues such as animal health systems, animal welfare initiatives, zoonoses, mastitis control and infectious disease control. Here, Kristy Ebanks focuses on two keynote addresses which considered the evolving role of the dairy vet. PMID:27585891

  12. Role of Water in Urban Ecology

    NASA Astrophysics Data System (ADS)

    Grigg, Neil S.

    1984-04-01

    This volume is a report on a symposium on the role of water in urban ecology held in Amsterdam in August 1979. The second international environmental symposium of the Koninklijke Nederlandsche Heide Maatschappij (Royal Netherlands Land Development Society) was cosponsored by the International Association for Ecology (INTECOL) and Elsevier Scientific Publishing Company with proceedings published in a special edition of the journal Urban Ecology, volume 6, pp. 1-362, from which this volume is reprinted.

  13. Department of Justice Role in Countering WMD

    SciTech Connect

    Prosnitz, D

    2004-01-12

    Stopping terrorist is most likely to be accomplished by state, local and federal law enforcement. With the creation of the Department of Homeland Security, the specific roles and responsibilities of the Department of Justice (DOJ) in preventing and responding to weapons of mass destruction (WMD) terrorist attacks are under reversion, but unquestionably the DOJ, as the chief federal law enforcement agency, will continue to have major responsibilities.

  14. A bank's role in EDI implementation.

    PubMed

    Cole, L; Windham, J W

    1995-03-01

    By improving accuracy and speed of accounting operations, financial electronic data interchange (EDI) can enhance a healthcare organization's cash flow. Banks play a key role in implementing EDI for accounts receivable. This article describes how a healthcare organization's bank can assist in EDI by translating incoming electronic payments into the healthcare organization's general ledger format, thus allowing the organization to take advantage of EDI without investing in expensive translation software. PMID:10146151

  15. The role of managers of science

    NASA Astrophysics Data System (ADS)

    Balázs, Béla

    We outline F.X. von Zach's activities as an editor, organizer and manager. In modern management, operational competence of managers is required, and we give the characteristics and behavior which are typical of successful manager-leaders. In scientific research team work, managers may also have an important task. We describe the role and function of scientists in management, and outline ways and means of jointly achieving desired goals.

  16. Role of impurities in fusion plasmas

    SciTech Connect

    Tokar, M. Z.

    2008-10-15

    The role of impurity at the plasma edge of fusion devices is considered by analysing the influence on radiation losses and anomalous transport of particle and energy. The conditions critical for the development of radiative instabilities leading to the formation of detachment and MARFE and those necessary for the creation of a stable radiating edge, protecting the wall elements from intensive heat loads, are analyzed. Mechanisms responsible for anomalous transport suppression with impurity seeding are elucidated.

  17. Social Media's New Role in Emergency Management

    SciTech Connect

    Ethan Huffman; Sara Prentice

    2008-03-01

    As technology continues to evolve, emergency management organizations must adapt to new ways of responding to the media and public. This paper examines a brief overview of social media's new role in emergency management. This includes definitions of social media, the benefits of utilizing social media, examples of social media being used and finally a discussion of how agencies, such as Department of Energy national laboratories, can begin including social media in their emergency management plans.

  18. Role of Deubiquitinating Enzymes in DNA Repair

    PubMed Central

    2015-01-01

    Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling. PMID:26644404

  19. The role of aviation in climate change

    NASA Astrophysics Data System (ADS)

    Fahey, D. W.

    2015-12-01

    Aviation emissions contribute to the radiative forcing (RF) of climate. Of importance are emissions of carbon dioxide (CO2), nitrogen oxides (NOx), aerosols and their precursors (soot and sulphate), and increased cloudiness in the form of persistent linear contrails and induced-cirrus cloudiness. Aviation operations have grown strongly over the past years and further growth is expected. This presentation will provide an updated perspective on new research and understanding of the role of aviation in climate and where uncertainties and gaps remain.

  20. The role of IL-37 in cancer.

    PubMed

    Ding, Vivi A; Zhu, Ziwen; Xiao, Huaping; Wakefield, Mark R; Bai, Qian; Fang, Yujiang

    2016-07-01

    Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis. PMID:27251377

  1. The role of precise time in IFF

    NASA Technical Reports Server (NTRS)

    Bridge, W. M.

    1982-01-01

    The application of precise time to the identification of friend or foe (IFF) problem is discussed. The simple concept of knowing when to expect each signal is exploited in a variety of ways to achieve an IFF system which is hard to detect, minimally exploitable and difficult to jam. Precise clocks are the backbone of the concept and the various candidates for this role are discussed. The compact rubidium-controlled oscillator is the only practical candidate.

  2. The role of hyaluronic acid in biomineralization

    NASA Astrophysics Data System (ADS)

    Chen, Zhen-Hua; Ren, Xiu-Li; Zhou, Hui-Hui; Li, Xu-Dong

    2012-12-01

    Hyaluronic acid has been extensively investigated due to intrinsic properties of natural origin and strong ability to bind ions in water. Hyaluronic acid is an excellent crystal modifier because its abundant negatively charged carboxyl groups can bind the cations protruding from the crystal lattice. In this review, we mainly present the latest work focus on the role of hyaluronic acid in controlling the crystallization, breaking the symmetry of crystal, and the surface funtionalization of nanocrystals.

  3. Flavonols: old compounds for old roles

    PubMed Central

    Pollastri, Susanna; Tattini, Massimiliano

    2011-01-01

    Background New roles for flavonoids, as developmental regulators and/or signalling molecules, have recently been proposed in eukaryotic cells exposed to a wide range of environmental stimuli. In plants, these functions are actually restricted to flavonols, the ancient and widespread class of flavonoids. In mosses and liverworts, the whole set of genes for flavonol biosynthesis – CHS, CHI, F3H, FLS and F3′H – has been detected. The flavonol branch pathway has remained intact for millions of years, and is almost exclusively involved in the responses of plants to a wide array of stressful agents, despite the fact that evolution of flavonoid metabolism has produced >10 000 structures. Scope Here the emerging functional roles of flavonoids in the responses of present-day plants to different stresses are discussed based on early, authoritative views of their primary functions during the colonization of land by plants. Flavonols are not as efficient as other secondary metabolites in absorbing wavelengths in the 290–320 nm spectral region, but display the greatest potential to keep stress-induced changes in cellular reactive oxygen species homeostasis under control, and to regulate the development of individual organs and the whole plant. Very low flavonol concentrations, as probably occurred in early terrestrial plants, may fully accomplish these regulatory functions. Conclusions During the last two decades the routine use of genomic, chromatography/mass spectrometry and fluorescence microimaging techniques has provided new insights into the regulation of flavonol metabolism as well as on the inter- and intracellular distribution of stress-responsive flavonols. These findings offer new evidence on how flavonols may have performed a wide array of functional roles during the colonization of land by plants. In our opinion this ancient flavonoid class is still playing the same old and robust roles in present-day plants. PMID:21880658

  4. Changing roles of researchers in industry

    NASA Astrophysics Data System (ADS)

    Brillson, Leonard

    1999-04-01

    Major changes have occurred in the industrial research environment over the past decade. Dynamic global competition in the marketplace has altered the traditional roles of physicists in industry while offering new career opportunities. This talk will describe the opportunities and challenges facing physicists in a wide spectrum of responsibilities, from the bench to the executive suite. Drawing on perspectives from several leading physics-based industries, the talk will highlight the skills and knowledge required for success in this new environment.

  5. Sex-Role Egalitarian Attitudes and Gender Role Socialization Experiences of African American Men and Women: A Mixed Methods Paradigm

    ERIC Educational Resources Information Center

    Heard, Courtney Christian Charisse

    2013-01-01

    The purpose of this study was to assess the sex-role egalitarian attitudes and gender role socialization experiences of African American men and women. A sequential mixed-methods design was employed to research this phenomenon. The Sex-Role Egalitarianism Scale-Short Form BB (SRES-BB) was utilized to assess sex-role egalitarian attitudes (King…

  6. ROLE OF THE TEACHER AND OCCUPATIONAL CHOICE. STUDIES IN THE ROLE OF THE PUBLIC SCHOOL TEACHER, VOLUME 4.

    ERIC Educational Resources Information Center

    BIDDLE, BRUCE J.; AND OTHERS

    ONE OF A SERIES OF STUDIES PERTAINING TO ROLE THEORY, THE ROLE OF THE PUBLIC SCHOOL TEACHER, AND THE RELATIONSHIPS BETWEEN TEACHER ROLE AND THE PROBLEMS OF TEACHER RECRUITMENT, THE INVESTIGATION EXAMINES DIFFERENCES IN TEACHER ROLES AS PERCEIVED BY TEACHERS, COLLEGE EDUCATION MAJORS, AND COLLEGE STUDENTS MAJORING IN OTHER FIELDS. IT IS ASSUMED…

  7. The role of autophagy in cardiac hypertrophy.

    PubMed

    Li, Lanfang; Xu, Jin; He, Lu; Peng, Lijun; Zhong, Qiaoqing; Chen, Linxi; Jiang, Zhisheng

    2016-06-01

    Autophagy is conserved in nature from lower eukaryotes to mammals and is an important self-cannibalizing, degradative process that contributes to the elimination of superfluous materials. Cardiac hypertrophy is primarily characterized by excess protein synthesis, increased cardiomyocyte size, and thickened ventricular walls and is a major risk factor that promotes arrhythmia and heart failure. In recent years, cardiomyocyte autophagy has been considered to play a role in controlling the hypertrophic response. However, the beneficial or aggravating role of cardiomyocyte autophagy in cardiac hypertrophy remains controversial. The exact mechanism of cardiomyocyte autophagy in cardiac hypertrophy requires further study. In this review, we summarize the controversies associated with autophagy in cardiac hypertrophy and provide insights into the role of autophagy in the development of cardiac hypertrophy. We conclude that future studies should emphasize the relationship between autophagy and the different stages of cardiac hypertrophy, as well as the autophagic flux and selective autophagy. Autophagy will be a potential therapeutic target for cardiac hypertrophy. PMID:27084518

  8. Role of interleukin-32 in chronic rhinosinusitis

    PubMed Central

    Keswani, Anjeni; Kern, Robert C.; Schleimer, Robert P.; Kato, Atsushi

    2013-01-01

    Purpose of review IL-32 is a recently described proinflammatory cytokine and has been reported to be involved in inflammatory diseases. The purpose of this review is to discuss the role of IL-32 in chronic rhinosinusitis (CRS). Recent findings Two groups have recently reported data regarding the expression of IL-32 in CRS. IL-32 was induced by IFN-γ, TNF-α, dsRNA, and incubation with Th1 cells in primary nasal epithelial cells. IL-32 may be elevated in epithelial cells from patients with CRS without nasal polyps. IL-32 was significantly elevated in whole sinonasal tissue samples of nasal polyps compared with control tissue. IL-32 mRNA expression positively correlated with mRNA for CD3 and macrophage mannose receptor in nasal polyp tissue. Immunohistochemical studies demonstrated localization of IL-32 in epithelium, CD3+ and CD68+ cells, suggesting that epithelial cells, T cells, and macrophages are the major IL-32-producing cells in CRS. Activation of these cell types may trigger IL-32-related inflammation in CRS. Summary Elevated levels of IL-32 may play a role in the pathogenesis of CRS through its role as a proinflammatory cytokine and as an endogenous enhancer of pathogen-dependent cytokine production. PMID:23242112

  9. Possible role of hemichannels in cancer

    PubMed Central

    Schalper, Kurt A.; Carvajal-Hausdorf, Daniel; Oyarzo, Mauricio P.

    2014-01-01

    In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors. Alteration of Cxs and Panxs in cancer cells can be due to genetic, epigenetic and post-transcriptional/post-translational events. Activated hemichannels mediate the diffusional membrane transport of ions and small signaling molecules. In the last decade hemichannels have been shown to participate in diverse cell processes including the modulation of cell proliferation and survival. However, their possible role in tumor growth and expansion remains largely unexplored. Herein, we hypothesize about the possible role of hemichannels in carcinogenesis and tumor progression. To support this theory, we summarize the evidence regarding the involvement of hemichannels in cell proliferation and migration, as well as their possible role in the anti-tumor immune responses. In addition, we discuss the evidence linking hemichannels with cancer in diverse models and comment on the current technical limitations for their study. PMID:25018732

  10. Neuropilins: role in signalling, angiogenesis and disease.

    PubMed

    Zachary, Ian

    2014-01-01

    Neuropilins (NRPs) are co-receptors for class 3 semaphorins and for members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines. Genetic analysis of the role of NRPs in mice shows that NRP1 is essential for embryonic neuronal pathfinding and cardiovascular development, mediated via semaphorins and VEGF, respectively, while NRP2 has a more restricted role in neuronal patterning and lymphangiogenesis. NRPs are thought to mediate functional responses, most importantly cell migration, as a result of complex formation with other receptors, such as plexins in the case of semaphorins and the VEGF receptor, VEGFR2, resulting in enhanced signalling via some intracellular pathways. Recent findings indicate that NRPs may have important biological roles in other physiological and disease-related processes. In particular, NRPs are highly expressed in diverse tumour cell lines and human neoplasms and have been implicated in several biological processes regulating tumour growth in vivo, suggesting that NRP1 may be a future therapeutic target in cancer. PMID:24217602

  11. The role of cannabinoids in adult neurogenesis

    PubMed Central

    Prenderville, Jack A; Kelly, Áine M; Downer, Eric J

    2015-01-01

    The processes underpinning post-developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both intrinsic (cell signalling cascades) and extrinsic (neurotrophins, neurotransmitters, cytokines, hormones) signalling molecules are intimately associated with adult neurogenesis and largely dictate the proliferative activity and differentiation capacity of neural cells. Cannabinoids are a unique class of chemical compounds incorporating plant-derived cannabinoids (the active components of Cannabis sativa), the endogenous cannabinoids and synthetic cannabinoid ligands, and these compounds are becoming increasingly recognized for their roles in neural developmental processes. Indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both CB1 and CB2 receptors. In recent years, a large body of literature has deciphered the signalling networks involved in cannabinoid-mediated regulation of neurogenesis. This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets. Overall, these findings identify the central role of the cannabinoid system in adult neurogenesis in the hippocampus and the lateral ventricles and hence provide insight into the processes underlying post-developmental neurogenesis in the mammalian brain. PMID:25951750

  12. Role of PAR-4 in ovarian cancer.

    PubMed

    Meynier, Sonia; Kramer, Marianne; Ribaux, Pascale; Tille, Jean-Christophe; Delie, Florence; Petignat, Patrick; Cohen, Marie

    2015-09-01

    Prostate apoptosis response-4 (PAR-4) is considered as a tumour suppressor due to its ability to selectively induce cell apoptosis in most cancer cells. However little is known about the role of PAR-4 in ovarian cancer. In this study, we investigated for the first time the role of PAR-4 in ovarian carcinogenesis. We showed that PAR-4 mRNA level is not significantly different between healthy and cancer ovarian cells. Immunohistochemistry on ovarian tissue showed that ovarian cancer cells are positive for PAR-4 nuclear and cytoplasmic staining whereas ovarian healthy cells are negative for PAR-4 nuclear staining. We then studied the role of PAR-4 in cell apoptosis. We determined that PAR-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of GRP78 from endoplasmic reticulum to the cell surface of ovarian cancer cell line (SKOV-3 cells). In ovo, PAR-4 decreases ovarian tumour development and increases the response to taxol treatment. These observations suggest that PAR-4 is a very interesting therapeutic target against ovarian carcinogenesis. PMID:26246468

  13. Performing dual roles in education and practice.

    PubMed

    Hackett, Natasha; Harvey-Lloyd, Jane; Rooke, Nickey

    2016-06-01

    Aim To examine the benefits and challenges of dual posts, defined here as lecturers who work in clinical practice and have separate contracts with different organisations. Methods A case study approach was used to collate different perspectives. Equal numbers of participants were selected from lecturers (n=3) and dual post holders (n= 3), and one manager was included (n=1). Semi-structured interviews were recorded and transcribed verbatim to collect data. Key words were identified then highlighted throughout the transcripts and text retrievers searched the large amounts of data gathered. Key words were grouped into multiple sub-themes, which were then further grouped into four themes. Findings Four main themes emerged from the data: duality, theory/practice, credibility and student experience. Some benefits and challenges of dual posts were identified. Benefits included helping students contextualise theory into practice and maintaining currency in practice. Challenges were maintaining a multifaceted role and managing expectations in both roles. Conclusion Dual post holders are regarded as an important part of the team by all stakeholders involved in this study. However, more clarification about the expectations of each role is required and post holders should have more support from their organisations. PMID:27246433

  14. Role of PAR-4 in ovarian cancer

    PubMed Central

    Meynier, Sonia; Kramer, Marianne; Ribaux, Pascale; Tille, Jean-Christophe; Delie, Florence; Petignat, Patrick; Cohen, Marie

    2015-01-01

    Prostate apoptosis response-4 (PAR-4) is considered as a tumour suppressor due to its ability to selectively induce cell apoptosis in most cancer cells. However little is known about the role of PAR-4 in ovarian cancer. In this study, we investigated for the first time the role of PAR-4 in ovarian carcinogenesis. We showed that PAR-4 mRNA level is not significantly different between healthy and cancer ovarian cells. Immunohistochemistry on ovarian tissue showed that ovarian cancer cells are positive for PAR-4 nuclear and cytoplasmic staining whereas ovarian healthy cells are negative for PAR-4 nuclear staining. We then studied the role of PAR-4 in cell apoptosis. We determined that PAR-4 induces cell apoptosis in response to stimuli, in vitro, but is also involved in the relocation of GRP78 from endoplasmic reticulum to the cell surface of ovarian cancer cell line (SKOV-3 cells). In ovo, PAR-4 decreases ovarian tumour development and increases the response to taxol treatment. These observations suggest that PAR-4 is a very interesting therapeutic target against ovarian carcinogenesis. PMID:26246468

  15. The role of imprinted genes in humans.

    PubMed

    Ishida, Miho; Moore, Gudrun E

    2013-01-01

    Genomic imprinting, a process of epigenetic modification which allows the gene to be expressed in a parent-of-origin specific manner, has an essential role in normal growth and development. Imprinting is found predominantly in placental mammals, and has potentially evolved as a mechanism to balance parental resource allocation to the offspring. Therefore, genetic and epigenetic disruptions which alter the specific dosage of imprinted genes can lead to various developmental abnormalities often associated with fetal growth and neurological behaviour. Over the past 20 years since the first imprinted gene was discovered, many different mechanisms have been implicated in this special regulatory mode of gene expression. This review includes a brief summary of the current understanding of the key molecular events taking place during imprint establishment and maintenance in early embryos, and their relationship to epigenetic disruptions seen in imprinting disorders. Genetic and epigenetic causes of eight recognised imprinting disorders including Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS), and also their association with Assisted reproductive technology (ART) will be discussed. Finally, the role of imprinted genes in fetal growth will be explored by investigating their relationship to a common growth disorder, intrauterine growth restriction (IUGR) and also their potential role in regulating normal growth variation. PMID:22771538

  16. Dynamic role of myofibroblasts in oral lesions

    PubMed Central

    Bagul, Neeta; Ganjre, Anjali; Goryawala, SN; Kathariya, Rahul; Dusane, Shrikant

    2015-01-01

    Fibroblasts are the most abundant cellular components of connective tissue. They possess phenotypical heterogenicity and may be present in the form of smooth muscle cells or myofibroblasts (MFs). MFs are spindle-shaped cells with stress fibres and well-developed fibronexus, and they display α-smooth muscle actin immunohistochemically and smooth-muscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived from various sources, they play pivotal roles not only by synthesizing and producing extracellular matrix components, such as other connective tissue cells, but also are involved in force production. In the tissue remodelling phase of wound closure, integrin-mediated interactions between MFs and type I collagen result in scar tissue formation. The tumour stroma in oral cancer actively recruits various cell types into the tumour mass, where they act as different sources of MFs. This article reviews the importance of MFs and its role in pathological processes such as wound healing, odontogenic cysts and tumours, salivary gland tumours, oral preneoplasia, and oral squamous cell carcinoma. Research oriented on blocking the transdifferentiation of fibroblasts into MFs can facilitate the development of noninvasive therapeutic strategies for the treatment of fibrosis and/or cancer. PMID:26677439

  17. Role of Extracellular Vesicles in Hematological Malignancies

    PubMed Central

    Raimondo, Stefania; Corrado, Chiara; Raimondi, Lavinia; De Leo, Giacomo; Alessandro, Riccardo

    2015-01-01

    In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies. Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery. Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies. PMID:26583135

  18. ROLE OF CHEMOKINES IN TUMOR GROWTH

    PubMed Central

    Raman, Dayanidhi; Baugher, Paige J.; Thu, Yee Mon; Richmond, Ann

    2007-01-01

    Chemokines play a paramount role in the tumor progression. Chronic inflammation promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and cytokines. These act either by autocrine or paracrine mechanisms to sustain tumor cell growth, induce angiogenesis and facilitate evasion of immune surveillance through immunoediting. The chemokine receptor CXCR2 and its ligands promote tumor angiogenesis and leukocyte infiltration into the tumor microenvironment. In harsh acidic and hypoxic microenvironmental conditions tumor cells up-regulate their expression of CXCR4, which equips them to migrate up a gradient of CXCL12 elaborated by carcinoma associated fibroblasts (CAFs) to a normoxic microenvironment. The CXCL12-CXCR4 axis facilitates metastasis to distant organs and the CCL21-CCR7 chemokine ligand-receptor pair favors metastasis to lymph nodes. These two chemokine ligand-receptor systems are common key mediators of tumor cell metastasis for several malignancies and as such provide key targets for chemotherapy. In this paper, the role of specific chemokines/chemokine receptor interactions in tumor progression, growth and metastasis and the role of chemokine/chemokine receptor interactions in the stromal compartment as related to angiogenesis, metastasis, and immune response to the tumor are reviewed. PMID:17629396

  19. Role of target geometry in phagocytosis

    PubMed Central

    Champion, Julie A.; Mitragotri, Samir

    2006-01-01

    Phagocytosis is a principal component of the body’s innate immunity in which macrophages internalize targets in an actin-dependent manner. Targets vary widely in shape and size and include particles such as pathogens and senescent cells. Despite considerable progress in understanding this complicated process, the role of target geometry in phagocytosis has remained elusive. Previous studies on phagocytosis have been performed using spherical targets, thereby overlooking the role of particle shape. Using polystyrene particles of various sizes and shapes, we studied phagocytosis by alveolar macrophages. We report a surprising finding that particle shape, not size, plays a dominant role in phagocytosis. All shapes were capable of initiating phagocytosis in at least one orientation. However, the local particle shape, measured by tangent angles, at the point of initial contact dictates whether macrophages initiate phagocytosis or simply spread on particles. The local shape determines the complexity of the actin structure that must be created to initiate phagocytosis and allow the membrane to move over the particle. Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume. PMID:16549762

  20. Role of Cellular Magnesium in Human Diseases

    PubMed Central

    Long, Samantha; Romani, Andrea MP

    2015-01-01

    Magnesium is required for many of the major organs to function and plays a crucial role in human and mammalian physiology. Magnesium is essential for the structure of bones and teeth, acts as a cofactor for more than 300 enzymes in the body, including binding to ATP for kinase reactions, and affects permeability of excitable membranes and neuromuscular transmission. Despite these essential roles, much is still unknown about magnesium physiology and homeostasis. Currently, nutritionists believe that the general population intakes insufficient magnesium daily through the diet. The effects of magnesium deficiency are, for the most part undetected, and simple, widespread assessments of magnesium intake remain unavailable for humans. Many of the patients admitted to hospitals or medical care facilities are unaware of their low magnesium levels. Moreover, because magnesium is predominantly an intracellular cation (>99%), serum magnesium levels remain a poor predictor of tissue magnesium content and availability. This review will discuss the effects of magnesium deficiency in various pathologies affecting the human population. The underlying causes for magnesium depletion in major physiological systems will be examined along with the involved signaling pathways and the main roles of magnesium homeostasis. Where possible (e.g. alcoholism), the implications of administering supplemental magnesium will be discussed. Ultimately, this review will advocate for the necessity of identifying easy and reproducible methods to assess serum and cellular magnesium levels and to identify magnesium deficiency in order to alleviate related pathological conditions. PMID:25839058