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Sample records for demonstrates dna-protective effects

  1. A novel liquid multi-phytonutrient supplement demonstrates DNA-protective effects.

    PubMed

    Baechler, Benjamin J; Nita, Florina; Jones, Lon; Frestedt, Joy L

    2009-06-01

    This study explored the DNA protective (anti-mutagenic) effects of an oral, liquid, multi-phytonutrient dietary supplement containing a proprietary blend of fruits, vegetables and aloe vera concentrated components in addition to a proprietary catechin complex from green tea (VIBE Cardiac & Life, Eniva Nutraceuticals, Anoka, MN; herein described as "VIBE"). This study tested the hypothesis that VIBE would reduce DNA damage in skin cells exposed to UVR. Human epidermal cells, from the cell line A431NS, were treated with 0% (control), 0.125%, 0.5%, 1% and 2% VIBE, and then exposed to 240 J/m(2) UVR. The amount of DNA damage was assessed using the COMET assay. At each concentration tested, a significantly smaller amount of DNA damage was measured by the COMET assay for the VIBE treated cells compared to the control cells exposed to UVR without VIBE. The dose response curves showed a maximal response at 0.5% VIBE with a threefold reduction in COMET tail density compared to the control samples without VIBE (p < 0.001). Additional research is warranted in human clinical trials to further explore the results of this study which demonstrated the DNA protective and anti-mutagenic effects of VIBE for human skin cells exposed to UVR-induced DNA damage. PMID:19255855

  2. Enhanced DPPH radical scavenging activity and DNA protection effect of litchi pericarp extract by Aspergillus awamori bioconversion

    PubMed Central

    2012-01-01

    Background Litchi (Litchi chinensis Sonn.) pericarp is a major byproduct which contains a significant amount of polyphenol. This study was designed to biotransformation litchi pericarp extract (LPE) by Aspergillus awamori to produce more bioactive compounds with stronger antioxidant activities. Results The study exhibited that the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities significantly (p < 0.05) increased from 15.53% to 18.23% in the water-extracted fraction and from 25.41% to 36.82% in the ethyl acetate-extracted fraction. Application of DNA cleavage assay further demonstrated the enhanced protection effect of the fermented phenolics on DNA damage. It is also noted that the water-extracted fraction of the fermented LPE possessed a much stronger capacity than the ethyl acetate-extracted fraction to prevent from damage of supercoiled DNA. Interestingly, it was found that some new compounds such as catechin and quercetin appeared after of A. awamori fermentation of LPE, which could account for the enhanced antioxidant activity. Conclusion The DPPH radical scavenging activity and DNA protection effect of LPE were increased by Aspergillus awamori bioconversion while some compounds responsible for the enhanced antioxidant activity were identified. This study provided an effective way of utilizing fruit pericarp as a readily accessible source of the natural antioxidants in food industry and, thus, extended the application area such as fruit by-products. PMID:23016522

  3. Assessment of antioxidative, chelating, and DNA-protective effects of selected essential oil components (eugenol, carvacrol, thymol, borneol, eucalyptol) of plants and intact Rosmarinus officinalis oil.

    PubMed

    Horvathova, Eva; Navarova, Jana; Galova, Eliska; Sevcovicova, Andrea; Chodakova, Lenka; Snahnicanova, Zuzana; Melusova, Martina; Kozics, Katarina; Slamenova, Darina

    2014-07-16

    Selected components of plant essential oils and intact Rosmarinus officinalis oil (RO) were investigated for their antioxidant, iron-chelating, and DNA-protective effects. Antioxidant activities were assessed using four different techniques. DNA-protective effects on human hepatoma HepG2 cells and plasmid DNA were evaluated with the help of the comet assay and the DNA topology test, respectively. It was observed that whereas eugenol, carvacrol, and thymol showed high antioxidative effectiveness in all assays used, RO manifested only antiradical effect and borneol and eucalyptol did not express antioxidant activity at all. DNA-protective ability against hydrogen peroxide (H2O2)-induced DNA lesions was manifested by two antioxidants (carvacrol and thymol) and two compounds that do not show antioxidant effects (RO and borneol). Borneol was able to preserve not only DNA of HepG2 cells but also plasmid DNA against Fe(2+)-induced damage. This paper evaluates the results in the light of experiences of other scientists. PMID:24955655

  4. Carvacrol and rosemary essential oil manifest cytotoxic, DNA-protective and pro-apoptotic effect having no effect on DNA repair.

    PubMed

    Melusova, M; Slamenova, D; Kozics, K; Jantova, S; Horvathova, E

    2014-01-01

    For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effects. In our study we assessed the cytotoxic, DNA-protective and pro-apoptotic effect of two frequently occurring natural compounds, carvacrol and rosemary essential oil, on human hepatoma HepG2 cells. In addition we examined the in vitro incision repair activity of liver cell extracts prepared from hepatocytes isolated from Sprague-Dawley (SD) rats fed with water containing carvacrol or rosemary oil. Using conventional and modified single cell gel electrophoresis we proved that incubation of HepG2 cells with selected concentrations of carvacrol and rosemary oil significantly protected cellular DNA against two dangerous oxidative agents, hydrogen peroxide (H(2)O(2)) and 2,3-dimethoxy-1,4-naphthoquinone (DMNQ). It is interesting that despite this DNA protection, the addition of both volatiles to the drinking water of SD rats had no effect on incision repair capacity of hepatocyte extracts. In this paper we also showed that carvacrol and rosemary oil can trigger apoptotic cell death pathways in HepG2 cells, which is probably connected with their cytotoxicity. PMID:25341996

  5. A Facile and Effective Chemiluminescence Demonstration Experiment

    ERIC Educational Resources Information Center

    Mohan, Arthur G.; Turro, Nicholas J.

    1974-01-01

    Describes a chemiluminescence system which can be used to demonstrate the effects of certain factors which affect the rate of reaction (temperature, concentration, catalysis, solvent, etc.), and to perform experiments relevant to the mechanism of the system. (SLH)

  6. Studying the Greenhouse Effect: A Simple Demonstration.

    ERIC Educational Resources Information Center

    Papageorgiou, G.; Ouzounis, K.

    2000-01-01

    Studies the parameters involved in a presentation of the greenhouse effect and describes a simple demonstration of this effect. Required equipment includes a 100-120 watt lamp, a 250mL beaker, and a thermometer capable of recording 0-750 degrees Celsius together with a small amount of chloroform. (Author/SAH)

  7. Experiments to Demonstrate Piezoelectric and Pyroelectric Effects

    ERIC Educational Resources Information Center

    Erhart, Jirí

    2013-01-01

    Piezoelectric and pyroelectric materials are used in many current applications. The purpose of this paper is to explain the basic properties of pyroelectric and piezoelectric effects and demonstrate them in simple experiments. Pyroelectricity is presented on lead zirconium titanate (PZT) ceramics as an electric charge generated by the temperature…

  8. Simple Demonstration of the Seebeck Effect

    ERIC Educational Resources Information Center

    Molki, Arman

    2010-01-01

    In this article we propose a simple and low-cost experimental set-up through which science educators can demonstrate the Seebeck effect using a thermocouple and an instrumentation amplifier. The experiment can be set up and conducted during a 1-hour laboratory session. (Contains 3 tables and 3 figures.)

  9. A Classroom Demonstration for Teaching Network Effects

    ERIC Educational Resources Information Center

    Sawler, James

    2007-01-01

    The introduction of the concept of network effects is useful at the principles level to facilitate discussions of the determinants of monopoly, the need for standards in high-tech industries, and the general complexity of real-world competition. The author describes a demonstration and an extension that help students understand how consumers make…

  10. Neocarzinostatin as a probe for DNA protection activity--molecular interaction with caffeine.

    PubMed

    Chin, Der-Hang; Li, Huang-Hsien; Kuo, Hsiu-Maan; Chao, Pei-Dawn Lee; Liu, Chia-Wen

    2012-04-01

    Neocarzinostatin (NCS), a potent mutagen and carcinogen, consists of an enediyne prodrug and a protein carrier. It has a unique double role in that it intercalates into DNA and imposes radical-mediated damage after thiol activation. Here we employed NCS as a probe to examine the DNA-protection capability of caffeine, one of common dietary phytochemicals with potential cancer-chemopreventive activity. NCS at the nanomolar concentration range could induce significant single- and double-strand lesions in DNA, but up to 75 ± 5% of such lesions were found to be efficiently inhibited by caffeine. The percentage of inhibition was caffeine-concentration dependent, but was not sensitive to the DNA-lesion types. The well-characterized activation reactions of NCS allowed us to explore the effect of caffeine on the enediyne-generated radicals. Postactivation analyses by chromatographic and mass spectroscopic methods identified a caffeine-quenched enediyne-radical adduct, but the yield was too small to fully account for the large inhibition effect on DNA lesions. The affinity between NCS chromophore and DNA was characterized by a fluorescence-based kinetic method. The drug-DNA intercalation was hampered by caffeine, and the caffeine-induced increases in DNA-drug dissociation constant was caffeine-concentration dependent, suggesting importance of binding affinity in the protection mechanism. Caffeine has been shown to be both an effective free radical scavenger and an intercalation inhibitor. Our results demonstrated that caffeine ingeniously protected DNA against the enediyne-induced damages mainly by inhibiting DNA intercalation beforehand. The direct scavenging of the DNA-bound NCS free radicals by caffeine played only a minor role. PMID:21538576

  11. Antioxidant, DNA protective efficacy and HPLC analysis of Annona muricata (soursop) extracts.

    PubMed

    George, V Cijo; Kumar, D R Naveen; Suresh, P K; Kumar, R Ashok

    2015-04-01

    Annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. In India, it has a long history of traditional use in treating various ailments. The present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of A. muricata, followed by validation of its radical scavenging and DNA protection activities. The extracts were also analyzed for its total phenolic contents and subjected to HPLC analysis to determine its active metabolites. The radical scavenging activities were premeditated by various complementary assays (DRSA, FRAP and HRSA). Further, its DNA protection efficacy against H2O2 induced toxicity was evaluated using pBR322 plasmid DNA. The results revealed that the extracts were highly rich in various phytochemicals including luteolin, homoorientin, tangeretin, quercetin, daidzein, epicatechin gallate, emodin and coumaric acid. Both the extracts showed significant (p < 0.05) radical scavenging activities, while methanolic extract demonstrated improved protection against H2O2-induced DNA damage when compared to aqueous extract. A strong positive correlation was observed for the estimated total phenolic contents and radical scavenging potentials of the extracts. Further HPLC analysis of the phyto-constituents of the extracts provides a sound scientific basis for compound isolation. PMID:25829616

  12. Demonstrating the Effects of Light Quality on Plant Growth.

    ERIC Educational Resources Information Center

    Whitesell, J. H.; Garcia, Maria

    1977-01-01

    Describes a lab demonstration that illustrates the effect of different colors or wavelengths of visible light on plant growth and development. This demonstration is appropriate for use in college biology, botany, or plant physiology courses. (HM)

  13. Demonstrations at School Level of the Effects of IAA

    ERIC Educational Resources Information Center

    Falk, Peter

    1973-01-01

    Describes demonstrations suitable for secondary school biology classes relating to the effects of the hormone IAA on plant growth. Demonstrations illustrate how hormone treatments affect stem elongation, callus formation, inhibition of axillary buds, stimulation of secondary growth and initiation of adventitious root development, root elongation,…

  14. A Simple Apparatus to Demonstrate the Peltier Effect

    ERIC Educational Resources Information Center

    Dougal, R. C.

    1974-01-01

    Discusses the Peltier, or thermoelectric effect, which provides a way of cooling a system by coupling it thermally to the junction of two materials suitably chosen, shaped, and connected to a d.c. current. Describes an apparatus which simply and inexpensively demonstrates this effect. (MLH)

  15. MOS: The Critical Elements of Doing Effective Classroom Demonstrations

    ERIC Educational Resources Information Center

    Shmaefsky, Brian R.

    2005-01-01

    MOS, or Minds-On-Science, is the foundation of conducting educationally valuable science demonstrations. It is a teaching strategy equally effective as hands-on-learning. Plus, it proves much more effective at reinforcing abstract science concepts than traditional lectures, readings, and audiovisual presentations. Adding MOS to a demonstration…

  16. Effects of a Demonstration Laboratory on Student Learning

    NASA Astrophysics Data System (ADS)

    McKee, Erik; Williamson, Vickie M.; Ruebush, Laura E.

    2007-10-01

    Laboratory and demonstration have long been used to supplement lecture in chemistry education. Current research indicates that students are better served by laboratories which exercise the higher-order cognitive skills, such as inquiry-based laboratories. However, the time and the resources available to perform these recommended types of laboratories are continually shrinking. Due to these factors, a demonstration-laboratory was designed to allow students to make observations through demonstration rather then through hands-on laboratory. For this study, the hands-on procedures of an inquiry style laboratory were replaced by an instructor demonstration of these same procedures. A significant difference was found between student conceptual understanding before and after the experiment, indicating that students performing the laboratory experiment and students viewing the demonstration-laboratory had an increase in conceptual understanding. However, no significant difference was found between the conceptual understanding of the two groups after the experiment, indicating that students learn roughly the same from both methods and that the demonstration-laboratory at least does no harm to the students conceptually. Long-term effects on student understanding were not measured. Student opinions comparing the demonstration laboratory to a hands-on laboratory were also collected and analyzed.

  17. Experimental demonstration of an Allee effect in microbial populations.

    PubMed

    Kaul, RajReni B; Kramer, Andrew M; Dobbs, Fred C; Drake, John M

    2016-04-01

    Microbial populations can be dispersal limited. However, microorganisms that successfully disperse into physiologically ideal environments are not guaranteed to establish. This observation contradicts the Baas-Becking tenet: 'Everything is everywhere, but the environment selects'. Allee effects, which manifest in the relationship between initial population density and probability of establishment, could explain this observation. Here, we experimentally demonstrate that small populations ofVibrio fischeriare subject to an intrinsic demographic Allee effect. Populations subjected to predation by the bacterivoreCafeteria roenbergensisdisplay both intrinsic and extrinsic demographic Allee effects. The estimated critical threshold required to escape positive density-dependence is around 5, 20 or 90 cells ml(-1)under conditions of high carbon resources, low carbon resources or low carbon resources with predation, respectively. This work builds on the foundations of modern microbial ecology, demonstrating that mechanisms controlling macroorganisms apply to microorganisms, and provides a statistical method to detect Allee effects in data. PMID:27048467

  18. The Mercury-Drag Effect, a Demonstration of Transport Phenomena

    ERIC Educational Resources Information Center

    Martin, D. H.; Teese, R. B

    1969-01-01

    The mercury-drag effect is demonstrated when mercury vapor diffuses through nitrogen gas at low pressure, passing through tubes of different radii to liquid nitrogen-cooled cold traps. The pressure changes of the nitrogen gas on the mercury-deficient side of the cold traps are observed and compared with theoretical and experimental valves from the…

  19. The Physics behind a Simple Demonstration of the Greenhouse Effect

    ERIC Educational Resources Information Center

    Buxton, Gavin A.

    2014-01-01

    A simple, and popular, demonstration of the greenhouse effect involves a higher temperature being observed in a container with an elevated concentration of CO[subscript 2] inside than in a container with just air enclosed, when subject to direct light. The CO[subscript 2] absorbs outgoing thermal radiation and causes the air inside the container…

  20. Demonstration of an Ice Contamination Effects Flight Training Device

    NASA Technical Reports Server (NTRS)

    Ratvasky, Thomas P.; Ranaudo, Richard J.; Blankenship, Kurt S.; Lee, Sam

    2006-01-01

    The development of a piloted flight simulator called the Ice Contamination Effects Flight Training Device (ICEFTD) was recently completed. This device demonstrates the ability to accurately represent an iced airplane s flight characteristics and is utilized to train pilots in recognizing and recovering from aircraft handling anomalies that result from airframe ice formations. The ICEFTD was demonstrated at three recent short courses hosted by the University of Tennessee Space Institute. It was also demonstrated to a group of pilots at the National Test Pilot School. In total, eighty-four pilots and flight test engineers from industry and the regulatory community spent approximately one hour each in the ICEFTD to get a "hands on" lesson of an iced airplane s reduced performance and handling qualities. Additionally, pilot cues of impending upsets and recovery techniques were demonstrated. The purpose of this training was to help pilots understand how ice contamination affects aircraft handling so they may apply that knowledge to the operations of other aircraft undergoing testing and development. Participant feedback on the ICEFTD was very positive. Pilots stated that the simulation was very valuable, applicable to their occupations, and provided a safe way to explore the flight envelope. Feedback collected at each demonstration was also helpful to define additional improvements to the ICEFTD; many of which were then implemented in subsequent demonstrations

  1. The DNA protection during starvation protein (Dps) influences attachment of Escherichia coli to abiotic surfaces.

    PubMed

    Goulter-Thorsen, Rebecca M; Gentle, Ian R; Gobius, Kari S; Dykes, Gary A

    2011-08-01

    The attachment of bacterial species such as Escherichia coli to abiotic materials is of concern to the food industry. This study investigated the role of DNA protection during starvation protein (Dps) in cell surface hydrophobicity and attachment of E. coli to glass, stainless steel, and Teflon surfaces. The Dps was not found to influence hydrophobicity, but did have a putative role in attachment in a strain- and substrate-dependent manner. PMID:21438764

  2. Experimental demonstration of topological effects in bianisotropic metamaterials

    PubMed Central

    Slobozhanyuk, Alexey P.; Khanikaev, Alexander B.; Filonov, Dmitry S.; Smirnova, Daria A.; Miroshnichenko, Andrey E.; Kivshar, Yuri S.

    2016-01-01

    Existence of robust edge states at interfaces of topologically dissimilar systems is one of the most fascinating manifestations of a novel nontrivial state of matter, a topological insulator. Such nontrivial states were originally predicted and discovered in condensed matter physics, but they find their counterparts in other fields of physics, including the physics of classical waves and electromagnetism. Here, we present the first experimental realization of a topological insulator for electromagnetic waves based on engineered bianisotropic metamaterials. By employing the near-field scanning technique, we demonstrate experimentally the topologically robust propagation of electromagnetic waves around sharp corners without backscattering effects. PMID:26936219

  3. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography

    PubMed Central

    Park, J. W.; Piknova, B.; Nghiem, K.; Lozier, J. N.; Schechter, A. N.

    2014-01-01

    Nitric oxide (NO) can be generated by two-step reduction pathway in which nitrate is converted first into nitrite and then into NO via several mechanisms, as well as from arginine by endogenous nitric oxide synthase (NOS). We have recently shown that nitrite ions in the presence of erythrocytes inhibit platelet aggregation and activation, as measured by aggregometry and flow cytometric analysis of P-selectin, through its reduction to NO under partially deoxygenated conditions. In the current study, we investigated how nitrite may affect overall clotting processes via modulating platelet function using thrombelastography (TEG). We measured three major TEG parameters, reaction time (R, time to initial fibrin formation), α angle (velocity of clot growth) and maximum amplitude (MA, maximum clot strength) using blood from healthy volunteers. An NO donor (DEANONOate) showed inhibitory effects on all TEG parameters in platelet rich plasma (PRP) and whole blood, resulting in delayed R, decreased angle, and reduced MA in a dose dependent manner. Nitrite ions also exhibited inhibitory effects in whole blood at 20% hematocrit, and this was greatly enhanced under hypoxic conditions, being demonstrable at 0.1 μM concentration. Neither compound changed any TEG parameters in plasma. Our results suggest that nitrite affects overall blood clotting and that TEG may be used to follow this process. Further the physiological effects of factors which determine NO bioavailability, such as endogenous levels of blood and tissue nitrite, may be useful as biomarkers for predicting hemostatic potential. PMID:24858214

  4. 30 CFR 553.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 553.43 Section 553.43 Mineral Resources BUREAU OF OCEAN ENERGY... of your or your indemnitor's current fiscal year....

  5. 30 CFR 253.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 253.43 Section 253.43 Mineral Resources BUREAU OF OCEAN ENERGY... of the 5th month after the close of your or your indemnitor's current fiscal year....

  6. 30 CFR 553.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 553.43 Section 553.43 Mineral Resources BUREAU OF OCEAN ENERGY... of your or your indemnitor's current fiscal year....

  7. 30 CFR 553.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 553.43 Section 553.43 Mineral Resources BUREAU OF OCEAN ENERGY... of your or your indemnitor's current fiscal year....

  8. 30 CFR 253.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 253.43 Section 253.43 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE...

  9. Antioxidant and cyto/DNA protective properties of apple pomace enriched bakery products.

    PubMed

    Sudha, M L; Dharmesh, Shylaja M; Pynam, Hasitha; Bhimangouder, Shivaleela V; Eipson, Sushma W; Somasundaram, Rajarathnam; Nanjarajurs, Shashirekha M

    2016-04-01

    Apple pomace (AP), the residue that remains after the extraction of juice from apple accounts for ~25 % of total apple weight. Current study is aimed at identification of phytochemicals and utilization of Dehydrated apple pomace (DAP) in the preparation of bakery products with potential health benefits. DAP was prepared by drying the pomace obtained by crushing peeled apple fruits. DAP was incorporated into bakery products such as bun, muffin and cookies for value addition. Bioactivity such as free radical scavenging, cyto/DNA protectivity was evaluated in these products. DAP contained 17 g/100 g starch, 49.86 g/100 g fructose and 37 g/100 g dietary fibre. The phenolics and flavonoids content was 1.5 mg/g and 3.92 mg/g, respectively. Increase in DAP resulted in decreased volume and enhanced firmness of buns and muffins. DAP at 15 % in buns, 30 % in muffins and 20 % in cookies were found to be acceptable. DAP blended products exhibited better free radical scavenging as well as cyto/DNA protective properties suggesting the retention of bioactivity after baking. Addition of DAP potentially enhanced the bioactivity of the products evaluated. PMID:27413217

  10. Demonstration of the greenhouse effect for elementary school students

    NASA Astrophysics Data System (ADS)

    Radovanovic, Jelena

    2014-05-01

    The school where I work is part of the "Step by step towards the sustainable development school" project. Project activities are partly directed towards the popularization of science. As a physics teacher, I have had the opportunity to engage in designing interactive workshops, aiming to introduce younger students to simple experiments which illustrate different natural phenomena, and also in organization, preparation and implementation of school and city science festival (in 2012 and 2013). Numerous displays, workshops and experiments served to introduce a large number of visitors to different topics in the area of science and technology. One of the subjects of forthcoming science festival, planned for May of 2014, is the climate change. To that effect, eight grade students will hold a demonstration and explanation of the greenhouse effect. Although the terms greenhouse effect and global warming are widely used in media, most of the elementary school students in Serbia have poor understanding of the underlying scientific concepts. The experiment with analysis and discussion will first be implemented in one eight-grade class (14 years of age). After that, a group of students from this class will present their newly-acquired knowledge to their peers and younger students at the science fair. Activity objectives: • Explain how atmosphere affects the surface temperature of Earth • Conduct an experiment to demonstrate the greenhouse effect • Analyze the consequences of climate changes Experiment description: Take two empty, transparent containers and add a layer of garden soil. Use cardboard or similar material to make housings for the thermometers. Hang them in the containers, so that they don't touch the soil. Cover one container with a glass panel, and leave the other one open. Place identical incandescent light bulbs at the same distance above each container. Turn the light bulbs on. The students should mark the thermometer readings every 2 minutes, for 20

  11. Classroom as Reality: Demonstrating Campaign Effects through Live Simulation

    ERIC Educational Resources Information Center

    Coffey, Daniel J.; Miller, William J.; Feuerstein, Derek

    2011-01-01

    Scholastic research has demonstrated that when conducted properly, active learning exercises are successful at increasing student awareness, student interest, and knowledge retention. Face-to-face simulations, in particular, have been demonstrated to add positively to classrooms focusing on comparative politics, international relations, public…

  12. A Simple Demonstration of the Effect of Eddy Currents

    ERIC Educational Resources Information Center

    Sapple, Paul; Reilly, Lee M.

    2013-01-01

    Demonstrating that a moving magnet can induce an electromagnetic force by causing an electric current in a conducting material can be shown by a number of methods. A common method is dropping a magnet down a copper pipe and showing that the rate of fall is much slower than expected owing to the induced electric current in the copper pipe. This…

  13. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts.

    PubMed

    Anter, Jaouad; Fernández-Bedmar, Zahira; Villatoro-Pulido, Myriam; Demyda-Peyras, Sebastian; Moreno-Millán, Miguel; Alonso-Moraga, Angeles; Muñoz-Serrano, Andrés; Luque de Castro, María Dolores

    2011-08-16

    Leaves of olive trees are an abundant raw material in the Mediterranean basin. They contain large amounts of potentially useful phytochemicals and could play beneficial roles in health care. In the present study, the principal bioactive phenols in olive-leaf extracts (OLEs) have been identified and quantified, and their genotoxic/antigenotoxic, cytotoxic and apoptotic effects have been assessed. The Somatic Mutation and Recombination Test (SMART) in wing imaginal discs of Drosophila melanogaster has been performed to test the possible genotoxicity of overall OLE and the individual components oleuropein and luteolin at different concentrations. The same assay was able to detect antigenotoxic activity against hydrogen peroxide as oxidative genotoxicant. None of the extracts/phenols tested showed significant mutagenic activity. This fact, together with the antigenotoxic activity against H(2)O(2) detected for all these extracts/phenols, confirmed the safety of OLE, oleuropein and luteolin in terms of DNA protection. HL60 human promyelocytic leukemia cells were used to assess the cytotoxic effects of the extracts/phenols. OLE, oleuropein and luteolin showed a dose-dependent cytotoxic effect with different IC50 (10μl/ml, 170μM, and 40μM, respectively). DNA fragmentation patterns and cell staining with acridine orange and ethidium bromide indicated that the mechanism for the cytotoxic effect of OLE, oleuropein and luteolin was the apoptotic pathway, with DNA laddering and cytoplasmic and nuclear changes. These results could help explain the mechanism of action that underlies the beneficial effect of OLE, proposed as a nutraceutical in the prevention of human cancer. PMID:21620995

  14. Demonstrating various quantum effects with two entangled laser beams

    NASA Astrophysics Data System (ADS)

    Hage, B.; Janoušek, J.; Armstrong, S.; Symul, T.; Bernu, J.; Chrzanowski, H. M.; Lam, P. K.; Bachor, H. A.

    2011-08-01

    We report on the preparation of entangled two mode squeezed states of yet unseen quality. Based on a measurement of the covariance matrix we found a violation of the Reid and Drummond EPR-criterion at a value of only 0.36 ± 0.03 compared to the threshold of 1. Furthermore, quantum state tomography was used to extract a single photon Fock state solely based on homodyne detection, demonstrating the strong quantum features of this pair of laser-beams. The probability for a single photon in this ensemble measurement exceeded 2/3.

  15. Have complementary therapies demonstrated effectiveness in rheumatoid arthritis?

    PubMed

    Fernández-Llanio Comella, Nagore; Fernández Matilla, Meritxell; Castellano Cuesta, Juan Antonio

    2016-01-01

    In recent decades the treatment of rheumatoid arthritis (RA) has improved thanks to the use of highly effective drugs. However, patients usually require long term therapy, which is not free of side effects. Therefore RA patients often demand complementary medicine, they seek additional sources of relief and/or less side effects. In fact 30-60% of rheumatic patients use some form of complementary medicine. Therefore, from conventional medicine, if we want to optimally treat our patients facilitating communication with them we must know the most commonly used complementary medicines. The aim of this review is to assess, based on published scientific research, what complementary therapies commonly used by patients with RA are effective and safe. PMID:26711840

  16. STUDY OF CHARACTERISTICS CONTRIBUTING TO THE EFFECTIVENESS OF VISUAL DEMONSTRATIONS.

    ERIC Educational Resources Information Center

    BOGUSLAVSKY, GEORGE W.

    SLIDES OF SELECTED TEXTBOOK ILLUSTRATIONS, DRAWN TO HIGHLIGHT THE PERTINENT AREAS OF THE ILLUSTRATION BY MEANS OF SHADING AND ILLUMINATION, WERE USED TO EVALUATE THEIR EFFECTIVENESS OVER SELECTED SLIDES OF CONVENTIONAL ILLUSTRATIONS AND DIAGRAMS IN WHICH ALL DETAILS WERE PROMINENTLY DISPLAYED. WHEN THE CONTROL SLIDES WERE PRESENTED, A TEACHER USED…

  17. Demonstrating Effectiveness of Antibiotics Against Known Bacteria Strains

    ERIC Educational Resources Information Center

    Keefe, Lois M.

    1977-01-01

    Procedures are described for showing the effectiveness of antibiotics (penicillin, ampicillin, and tetracycline) against a nonpathogenic bacteria strain (Bacillus cereus). Methods are outlined for preparing nutrient agar, sterilizing tubes, pouring agar plates, preparing antibiotic discs, and transferring antibiotic discs to agar plates. (CS)

  18. Polymer Photooxidation: An Experiment to Demonstrate the Effect of Additives.

    ERIC Educational Resources Information Center

    Allen, Norman S.; McKellar, John F.

    1979-01-01

    This undergraduate experiment shows that the inclusion of an appropriate additive can have a very marked effect on the physical properties of a polymer. The polymer used is polypropylene and the additives are 2-hydroxy-4-octyloxy-benzophenone and benzophenone. (BB)

  19. Classroom Demonstration of the Visual Effects of Eye Diseases

    PubMed Central

    Raphail, Ann-Marie; Bach, Emily C.; Hallock, Robert M.

    2014-01-01

    An understanding of the visual system is a fundamental aspect of many neuroscience and psychology courses. These classes often cover a variety of visual diseases that are correlated with the anatomy of the visual system, e.g., cataracts are caused by a clouding of the lens. Here, we describe an easy way to modify standard laboratory glasses/goggles to simulate the various perceptual deficits that accompany vision disorders such as astigmatism, cataracts, diabetic retinopathy, glaucoma, optic neuritis, posterior vitreous detachment, and retinitis pigmentosa. For example, when teaching about cataracts, students can put on glasses that mimic how severe cataracts affect one’s vision. Using the glasses will allow students to draw connections between the disorder, its perceptual deficits, and the underlying anatomy. We also discuss floaters in the eye and provide an easy method to allow students to detect their own floaters. Together, these demonstrations make for a more dynamic and interactive class on the visual system that will better link diseases of the eye to anatomy and perception, and allow undergraduate students to develop a better understanding of the visual system as a whole. PMID:24693262

  20. A Simple Demonstration of Convective Effects on Reaction-Diffusion Systems: A Burning Cigarette.

    ERIC Educational Resources Information Center

    Pojman, John A.

    1990-01-01

    Described is a demonstration that provides an introduction to nonequilibrium reaction-diffusion systems and the coupling of hydrodynamics to chemical reactions. Experiments that demonstrate autocatalytic behavior that are effected by gravity and convection are included. (KR)

  1. Mixing, Matching, and Mating: Demonstrating the Effect of Contrast on Relationship Satisfaction

    ERIC Educational Resources Information Center

    Lewis, Brian P.; Gurung, Regan A. R.

    2003-01-01

    We extended earlier demonstrations of the matching phenomenon (individuals choose romantic partners who tend to match them on a variety of traits) to demonstrate several relationship issues including contrast effects, the impact of alternative mates on relationship satisfaction, and social exchange and equity theories. Students first place playing…

  2. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin.

    PubMed

    Carvalho-Silva, Ronaldo; Pereira, Alanna Cibelle Fernandes; Dos Santos Alves, Rúbens Prince; Guecheva, Temenouga N; Henriques, João A P; Brendel, Martin; Pungartnik, Cristina; Rios-Santos, Fabrício

    2016-01-01

    Garcinia mangostana, popularly known as "mangosteen fruit," originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing. We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen extract [HEGM, 10 to 640 μg/mL] in established test assays (Comet assay, micronucleus test, and Salmonella/microsome test). In the Comet assay, HEGM-exposed human leukocytes showed no DNA damage. No significant HEGM-induced mutation in TA98 and TA100 strains of Salmonella typhimurium (with or without metabolic activation) was observed and HEGM-exposed human lymphocytes had no increase of micronuclei. However, HEGM suggested exposure concentration-dependent antigenotoxic potential in leukocytes and antioxidant potential in the yeast Saccharomyces cerevisiae. HEGM preloading effectively protected against H2O2-induced DNA damage in leukocytes (Comet assay). Preloading of yeast with HEGM for up to 4 h significantly protected the cells from lethality of chronic H2O2-exposure, as expressed in better survival. Absence of genotoxicity and demonstration of an antigenotoxic and antioxidant potential suggest that HEGM or some substances contained in it may hold promise for pharmaceutical or nutraceutical application. PMID:27042187

  3. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin

    PubMed Central

    Carvalho-Silva, Ronaldo; Pereira, Alanna Cibelle Fernandes; dos Santos Alves, Rúbens Prince; Guecheva, Temenouga N.; Henriques, João A. P.; Brendel, Martin; Rios-Santos, Fabrício

    2016-01-01

    Garcinia mangostana, popularly known as “mangosteen fruit,” originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing. We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen extract [HEGM, 10 to 640 μg/mL] in established test assays (Comet assay, micronucleus test, and Salmonella/microsome test). In the Comet assay, HEGM-exposed human leukocytes showed no DNA damage. No significant HEGM-induced mutation in TA98 and TA100 strains of Salmonella typhimurium (with or without metabolic activation) was observed and HEGM-exposed human lymphocytes had no increase of micronuclei. However, HEGM suggested exposure concentration-dependent antigenotoxic potential in leukocytes and antioxidant potential in the yeast Saccharomyces cerevisiae. HEGM preloading effectively protected against H2O2-induced DNA damage in leukocytes (Comet assay). Preloading of yeast with HEGM for up to 4 h significantly protected the cells from lethality of chronic H2O2-exposure, as expressed in better survival. Absence of genotoxicity and demonstration of an antigenotoxic and antioxidant potential suggest that HEGM or some substances contained in it may hold promise for pharmaceutical or nutraceutical application. PMID:27042187

  4. Virgin Olive Oil Enriched with Its Own Phenols or Complemented with Thyme Phenols Improves DNA Protection against Oxidation and Antioxidant Enzyme Activity in Hyperlipidemic Subjects.

    PubMed

    Romeu, Marta; Rubió, Laura; Sánchez-Martos, Vanessa; Castañer, Olga; de la Torre, Rafael; Valls, Rosa M; Ras, Rosa; Pedret, Anna; Catalán, Úrsula; López de las Hazas, María del Carmen; Motilva, María J; Fitó, Montserrat; Solà, Rosa; Giralt, Montserrat

    2016-03-01

    The effects of virgin olive oil (VOO) enriched with its own phenolic compounds (PC) and/or thyme PC on the protection against oxidative DNA damage and antioxidant endogenous enzymatic system (AEES) were estimated in 33 hyperlipidemic subjects after the consumption of VOO, VOO enriched with its own PC (FVOO), or VOO complemented with thyme PC (FVOOT). Compared to pre-intervention, 8-hydroxy-2'-deoxyguanosine (a marker for DNA damage) decreased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in olive and thyme phenolic metabolites. Superoxide dismutase (AEES enzyme) significantly increased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in thyme phenolic metabolites. When all three oils were compared, FVOOT appeared to have the greatest effect in protecting against oxidative DNA damage and improving AEES. The sustained intake of a FVOOT improves DNA protection against oxidation and AEES probably due to a greater bioavailability of thyme PC in hyperlipidemic subjects. PMID:26889783

  5. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1981-01-01

    Presents: (1) a simple demonstration which illustrates the driving force of entropy using the familiar effects of the negative thermal expansion coefficient of rubber; and (2) a demonstration of tetrahedral bonding using soap films. (CS)

  6. Effective Use of Demonstration Assessments in the Classroom Relative to Laboratory Topics

    ERIC Educational Resources Information Center

    Pierce, David T.; Pierce, Thomas W.

    2007-01-01

    Demonstrations assessment techniques are shown to be more effective in the teaching process, as compared to the normally used laboratory topics and aids. These assessments improve learning and help students learn the principles or concepts underlying chemistry.

  7. Tested Demonstrations: Visualization of Buffer Action and the Acidifying Effect of Carbon Dioxide.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1985-01-01

    Presents a buffer demonstration which features visualization of the effects of carbon dioxide on pH. Background information, list of materials needed, procedures used, and a discussion of results obtained are included. (JN)

  8. Experimental demonstration of quenched transmission effect of an ultrathin metallic grating.

    PubMed

    Kim, Sung W; Pang, Lin; Hong, Brandon; Ptasinski, Joanna; Fainman, Yeshaiahu

    2016-04-01

    We report on the experimental study of an anomalous transmission effect in ultrathin metallic gratings, where the metal thickness is much thinner than the skin depth. In particular, incident transverse magnetic polarized waves are reflected while incident transverse electric polarized waves are transmitted. This anomalous effect is strongly dependent on the metal thickness and metal width. We systematically investigate and demonstrate the anomalous effect and find the optimized nanostrip thickness and width by introducing a shadow-mask fabrication approach. Our results demonstrate the possibility of developing ultrathin nanostrip based planar metasurfaces with low loss. PMID:27192277

  9. Effects of Expanded Coverage for Chiropractic Services on Medicare Costs in a CMS Demonstration

    PubMed Central

    Stason, William B.; Ritter, Grant A; Prottas, Jeffrey; Tompkins, Christopher; Shepard, Donald S.

    2016-01-01

    Background Moderately convincing evidence supports the benefits of chiropractic manipulations for low back pain. Its effectiveness in other applications is less well documented, and its cost-effectiveness is not known. These questions led the Centers for Medicaid and Medicare Services (CMS) to conduct a two-year demonstration of expanded Medicare coverage for chiropractic services in the treatment of beneficiaries with neuromusculoskeletal (NMS) conditions affecting the back, limbs, neck, or head. Methods The demonstration was conducted in 2005–2007 in selected counties of Illinois, Iowa, and Virginia and the entire states of Maine and New Mexico. Medicare claims were compiled for the preceding year and two demonstration years for the demonstration areas and matched comparison areas. The impact of the demonstration was analyzed through multivariate regression analysis with a difference-in-difference framework. Results Expanded coverage increased Medicare expenditures by $50 million or 28.5% in users of chiropractic services and by $114 million or 10.4% in all patients treated for NMS conditions in demonstration areas during the two-year period. Results varied widely among demonstration areas ranging from increased costs per user of $485 in Northern Illinois and Chicago counties to decreases in costs per user of $59 in New Mexico and $178 in Scott County, Iowa. Conclusion The demonstration did not assess possible decreases in costs to other insurers, out-of-pocket payments by patients, the need for and costs of pain medications, or longer term clinical benefits such as avoidance of orthopedic surgical procedures beyond the two-year period of the demonstration. It is possible that other payers or beneficiaries saved money during the demonstration while costs to Medicare were increased. PMID:26928221

  10. Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects.

    PubMed

    Møller, Anders Pape; Mousseau, Timothy Alexander

    2013-01-01

    Recent nuclear accidents have prompted renewed interest in the fitness consequences of low-dose radiation. Hiyama et al. provided information on such effects in the Japanese pale grass blue butterfly in a paper that has been viewed more than 300,000 times, prompting a barrage of criticism. These exchanges highlight the role of scrutiny in studies with potential effects on humans, but also raise questions about minimum requirements for demonstrating biological effects. PMID:23987799

  11. Graded photonic crystals curve the flow of light: An experimental demonstration by the mirage effect

    NASA Astrophysics Data System (ADS)

    Akmansoy, Eric; Centeno, Emmanuel; Vynck, Kevin; Cassagne, David; Lourtioz, Jean-Michel

    2008-03-01

    We report the experimental demonstration of a beam curvature in graded photonic crystals via a spectacular mirage effect. A two-dimensional structure of metallic rods is constructed to produce this effect in the microwave domain near 10GHz. Experimental results are in excellent agreement with theoretical predictions, thus, proving the versatility of graded photonic crystals in view of their integration in future photonic circuits.

  12. Secondary Schools Demonstration Project: Program Effects of School-Based Interventions on Antisocial Behaviour

    ERIC Educational Resources Information Center

    Wright, Robin; Offord, David; John, Lindsay; Duku, Eric; DeWit, David

    2005-01-01

    This article describes the methodology and program effects of the Secondary Schools Demonstration Project (SSDP) conducted in four Ontario schools. The objective of the study was to evaluate the extent to which a universal program model of three interventions--cooperative learning; classroom management; and peer-helping approaches that included…

  13. Tested Demonstrations: The Effect of Free Radical Stability on the Rate of Bromination of Hydrocarbons.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.; And Others

    1980-01-01

    Presents a demonstration of the effect of alkyl free radical stability on the rate of free radical halogenation of hydrocarbons. The arenes toluene, ethylbenzene and comene are photobrominated comparatively, using an overhead projector both to provide a light source for the chemical reaction and to project the results on a screen. (CS)

  14. Adult Dyslexic Readers Do Not Demonstrate Regularity Effects in Sentence Processing: Evidence from Eye-Movements

    ERIC Educational Resources Information Center

    Jones, Manon Wyn; Kelly, M. Louise; Corley, Martin

    2007-01-01

    We report an eye-movement study that demonstrates differences in regularity effects between adult developmental dyslexic and control non-impaired readers, in contrast to findings from a large number of word recognition studies (see G. Brown, 1997). For low frequency words, controls showed an advantage for Regular items, in which…

  15. The Effect of Group Works and Demonstrative Experiments Based on Conceptual Change Approach: Photosynthesis and Respiration

    ERIC Educational Resources Information Center

    Cibik, Ayse Sert; Diken, Emine Hatun; Darcin, Emine Selcen

    2008-01-01

    The purpose of this study is to investigate the effect of the use of group works and demonstration experiments based on conceptual change approach in the elimination of misconception about the subject of photosynthesis and respiration in plants in pre-service science teachers. This study was conducted with 78 pre-service science teachers including…

  16. Evaluation of antibacterial, antioxidant and DNA protective capacity of Chenopodium album's ethanolic leaf extract.

    PubMed

    Elif Korcan, S; Aksoy, Onur; Erdoğmuş, S Feyza; Ciğerci, İ Hakkı; Konuk, Muhsin

    2013-01-01

    We have investigated the antibacterial effects of Chenopodium album's ethanolic leaf extract (CAE) on all the Gram (+) and Gram (-) microorganisms and evaluated the protective effects of CAE on both yeast and human mononuclear leukocytes' genomic DNA upon oxidative shock. Antibacterial activity was recorded on Bacillus subtilis with 13 mm of inhibition zone. Total oxidative status (TOS) and the total antioxidative status (TAS) levels were determined to evaluate the antioxidant activity of CAE. Results indicated that there was a good correlation between dose of CAE and TAS levels. We also observed that CAE protect the DNA of both yeast and mononuclear leukocytes against the damaging effect of hydrogen peroxide. The comet assay, applied on both Saccharomyces cerevisiae BY4741 (MATa his3Δ1 leu2Δ0 met15Δ0 ura3Δ0) and human leukocytes, results suggested that there was statistically significant correlation between CAE dilutions and antigenotoxic activity. PMID:22897836

  17. Diarylheptanoids from green alder bark and their potential for DNA protection.

    PubMed

    Novaković, Miroslav; Stanković, Miroslava; Vučković, Ivan; Todorović, Nina; Trifunović, Snežana; Apostolović, Danijela; Mandić, Boris; Veljić, Milan; Marin, Petar; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan

    2014-06-01

    Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine. PMID:24934673

  18. Pharmacodynamic properties of faropenem demonstrated by studies of time-kill kinetics and postantibiotic effect.

    PubMed

    Boswell, F J; Andrews, J M; Wise, R

    1997-03-01

    The pharmacodynamic properties of faropenem, a new oral penem antibiotic, were investigated by studying time-kill kinetics and postantibiotic effect. Time-kill kinetics were employed against strains of Bacteroides fragilis, Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes. The postantibiotic effects of faropenem were studied using strains of E. coli, S. aureus, H. influenzae and Streptococcus pneumoniae. The time-kill kinetic data demonstrated that faropenem has bactericidal activity. Faropenem exhibited a significant postantibiotic effect against all strains except H. influenzae. PMID:9096193

  19. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1990-01-01

    Described are demonstrations designed to reveal the important "nonsolvent" properties of water through its interaction with a toy called "Magic Sand" and other synthetic silica derivatives, especially those bonded with organic moities. The procedures for seven demonstrations along with a discussion of the effects are presented. (CW)

  20. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L.

    1982-01-01

    Two demonstrations are described: (1) a sunset effect using a gooseneck lamp and 20 sheets of paper and (2) the preparation and determination of structural features of dimethyl sulfoxide (DMSO) by infrared spectroscopy. (SK)

  1. Molecular characterization, immune responses and DNA protection activity of rock bream (Oplegnathus fasciatus), peroxiredoxin 6 (Prx6).

    PubMed

    De Zoysa, Mahanama; Ryu, Jae-Ho; Chung, Hee-Chung; Kim, Cheol-Hee; Nikapitiya, Chamilani; Oh, Chulhong; Kim, Hyowon; Saranya Revathy, K; Whang, Ilson; Lee, Jehee

    2012-07-01

    In this study, we describe the molecular characterization, immune responses of rock bream, Oplegnathus fasciatus peroxiredoxin 6 cDNA (RbPrx6) and DNA protection activity of its recombinant protein. The full-length cDNA sequence of RbPrx6 was identified after pyrosequencing of rock bream cDNA library. RbPrx6 consists of 663 bp open reading frame (ORF) that codes for a putative protein of 221 amino acids with predicted molecular mass of 27 kDa. It showed characteristic peroxiredoxin super-family domain similar to vertebrate Prx counterparts. In the pair-wise comparison, RbPrx6 showed the highest amino acid identity (92.8%) to Scophthalmus maximus Prx6. Real-time RT-PCR analysis revealed that constitutive expression of RbPrx6 transcripts in eleven tissues selected from un-challenged fish showing the highest level in liver. Synthetic polyinosinic:polycytidylic acid (poly I:C) and iridovirus containing supernatant, up-regulated the RbPrx6 mRNA in liver. Purified recombinant RbPrx6 protein was able to protect supercoiled plasmid DNA from damages that is induced by metal-catalyzed generation of reactive oxygen species. Our results suggest that RbPrx6 may play an important role in regulating oxidative stress by scavenging of ROS, involving immune reactions and minimizing the DNA damage in rock bream. PMID:22484606

  2. Actin and DNA Protect Histones from Degradation by Bacterial Proteases but Inhibit Their Antimicrobial Activity

    PubMed Central

    Sol, Asaf; Skvirsky, Yaniv; Blotnick, Edna; Bachrach, Gilad; Muhlrad, Andras

    2016-01-01

    Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis, and infection – induced cell death, histones are released from the cell. The extracellular histones have strong antimicrobial activity but are also cytotoxic and thought as mediators of cell death in sepsis. The antimicrobial activity of the cationic extracellular histones is inhibited by the polyanionic DNA and F-actin, which also become extracellular upon cell death. DNA and F-actin protect histones from degradation by the proteases of Pseudomonas aeruginosa and Porphyromonas gingivalis. However, though the integrity of the histones is protected, the activity of histones as antibacterial agents is lost. The inhibition of the histone’s antibacterial activity and their protection from proteolysis by DNA and F-actin indicate a tight electrostatic interaction between the positively charged histones and negatively charged DNA and F-actin, which may have physiological significance in maintaining the equilibrium between the beneficial antimicrobial activity of extracellular histones and their cytotoxic effects. PMID:27555840

  3. An expert panel report of a proposed scientific model demonstrating the effectiveness of antibacterial handwash products.

    PubMed

    Boyce, John M; Dupont, Herbert L; Massaro, Joseph; Sack, David; Schaffner, Donald W

    2012-10-01

    In 2005, a US Food and Drug Administration Nonprescription Drug Advisory Committee (NDAC) review of consumer antiseptic handwash product studies concluded that the data regarding existing products failed to demonstrate any association between specific log reductions of bacteria achieved by antiseptic handwashing and reduction of infection. The NDAC recommended that consumer antibacterial handwashing products should demonstrate a reduction in infection compared with non-antibacterial handwash products. In response to the NDAC review, a consumer product industry-sponsored expert panel meeting was held in October 2007 to review new methods for assessing the efficacy of antibacterial handwashes. The expert panel reviewed a newly proposed model for linking the effectiveness of antibacterial handwashing to infection reduction and made recommendations for conducting future studies designed to demonstrate the efficacy of antibacterial handwash formulations. The panel concluded that using the surrogate infection model to demonstrate efficacy has a sound scientific basis, that the use of Shigella flexneri as a test organism coupled with a modified hand contamination procedure is supported by published data, and that the model represents a realistic test for the efficacy of consumer antibacterial handwash products. This article summarizes the expert panel's deliberations, conclusions, and recommendations. PMID:22300895

  4. Music-of-light stethoscope: a demonstration of the photoacoustic effect

    NASA Astrophysics Data System (ADS)

    Nikitichev, D. I.; Xia, W.; Hill, E.; Mosse, C. A.; Perkins, T.; Konyn, K.; Ourselin, S.; Desjardins, A. E.; Vercauteren, T.

    2016-07-01

    In this paper we present a system aimed at demonstrating the photoacoustic (PA) effect for educational purposes. PA imaging is a hybrid imaging modality that requires no contrast agent and has a great potential for spine and brain lesion characterisation, breast cancer and blood flow monitoring notably in the context of fetal surgery. It relies on combining light excitation with ultrasound reception. Our brief was to present and explain PA imaging in a public-friendly way suitable for a variety of ages and backgrounds. We developed a simple, accessible demonstration unit using readily available materials. We used a modulated light emitting diode (LED) torch and an electronic stethoscope. The output of a music player was used for light modulation and the chest piece of the stethoscope covered by a black tape was used as an absorbing target and an enclosed chamber. This demonstration unit was presented to the public at the Bloomsbury Festival On Light in October 2015. Our stall was visited by over 100 people of varying ages. Twenty families returned in-depth evaluation questionnaires, which show that our explanations of the photoacoustic effect were well understood. Their interest in biomedical engineering was increased.

  5. Comprehensive Health Effects Testing Program for Denver's Potable Water Reuse Demonstration Project.

    PubMed

    Lauer, W C; Johns, F J; Wolfe, G W; Myers, B A; Condie, L W; Borzelleca, J F

    1990-08-01

    The Comprehensive Health Effects Testing Program for the Denver Water Department's Potable Water Reuse Demonstration Project is designed to evaluate the relative health effects of highly treated reclaimed water derived from secondary wastewater compared to Denver's present high-quality drinking water. The 1 million gallon per day (1 mgd) demonstration plant provides water to be evaluated in the studies treating unchlorinated secondary treated wastewater with the following additional processes: high pH lime clarification, recarbonation, filtration, ultraviolet irradiation, activated carbon adsorption, reverse osmosis, air stripping, ozonation, and chloramination. An additional sample is obtained from the identical treatment process substituting ultrafiltration for reverse osmosis. The toxicology tests to evaluate the possible long-term health effects are chronic toxicity and oncogenicity studies in Fischer 344 rats and B6C3F1 mice and reproductive/teratology in Sprague-Dawley rats. The results of these evaluations will be correlated with microbiological, chemical, and physical test results to establish the relative quality of reclaimed water compared to all established health standards as well as Denver's pristine drinking water. PMID:2388301

  6. Demonstration of large field effect in topological insulator films via a high-κ back gate

    NASA Astrophysics Data System (ADS)

    Wang, C. Y.; Lin, H. Y.; Yang, S. R.; Chen, K. H. M.; Lin, Y. H.; Chen, K. H.; Young, L. B.; Cheng, C. K.; Fanchiang, Y. T.; Tseng, S. C.; Hong, M.; Kwo, J.

    2016-05-01

    The spintronics applications long anticipated for topological insulators (TIs) has been hampered due to the presence of high density intrinsic defects in the bulk states. In this work we demonstrate the back-gating effect on TIs by integrating Bi2Se3 films 6-10 quintuple layer (QL) thick with amorphous high-κ oxides of Al2O3 and Y2O3. Large gating effect of tuning the Fermi level EF to very close to the band gap was observed, with an applied bias of an order of magnitude smaller than those of the SiO2 back gate, and the modulation of film resistance can reach as high as 1200%. The dependence of the gating effect on the TI film thickness was investigated, and ΔN2D/ΔVg varies with TI film thickness as ˜t-0.75. To enhance the gating effect, a Y2O3 layer thickness 4 nm was inserted into Al2O3 gate stack to increase the total κ value to 13.2. A 1.4 times stronger gating effect is observed, and the increment of induced carrier numbers is in good agreement with additional charges accumulated in the higher κ oxides. Moreover, we have reduced the intrinsic carrier concentration in the TI film by doping Te to Bi2Se3 to form Bi2TexSe1-x. The observation of a mixed state of ambipolar field that both electrons and holes are present indicates that we have tuned the EF very close to the Dirac Point. These results have demonstrated that our capability of gating TIs with high-κ back gate to pave the way to spin devices of tunable EF for dissipationless spintronics based on well-established semiconductor technology.

  7. Technology demonstration: geostatistical and hydrologic analysis of salt areas. Assessment of effectiveness of geologic isolation systems

    SciTech Connect

    Doctor, P.G.; Oberlander, P.L.; Rice, W.A.; Devary, J.L.; Nelson, R.W.; Tucker, P.E.

    1982-09-01

    The Office of Nuclear Waste Isolation (ONWI) requested Pacific Northwest Laboratory (PNL) to: (1) use geostatistical analyses to evaluate the adequacy of hydrologic data from three salt regions, each of which contains a potential nuclear waste repository site; and (2) demonstrate a methodology that allows quantification of the value of additional data collection. The three regions examined are the Paradox Basin in Utah, the Permian Basin in Texas, and the Mississippi Study Area. Additional and new data became available to ONWI during and following these analyses; therefore, this report must be considered a methodology demonstration here would apply as illustrated had the complete data sets been available. A combination of geostatistical and hydrologic analyses was used for this demonstration. Geostatistical analyses provided an optimal estimate of the potentiometric surface from the available data, a measure of the uncertainty of that estimate, and a means for selecting and evaluating the location of future data. The hydrologic analyses included the calculation of transmissivities, flow paths, travel times, and ground-water flow rates from hypothetical repository sites. Simulation techniques were used to evaluate the effect of optimally located future data on the potentiometric surface, flow lines, travel times, and flow rates. Data availability, quality, quantity, and conformance with model assumptions differed in each of the salt areas. Report highlights for the three locations are given.

  8. Spherical Primary Optical Telescope (SPOT): An Architecture Demonstration for Cost-effective Large Space Telescopes

    NASA Technical Reports Server (NTRS)

    Feinberg, Lee; Hagopian, John; Budinoff, Jason; Dean, Bruce; Howard, Joe

    2005-01-01

    This paper summarizes efforts underway at the Goddard Space Flight Center to demonstrate a new type of space telescope architecture that builds on the rigid, segmented telescope heritage of the James Webb Space Telescope but that solves several key challenges for future space telescopes. The architecture is based on a cost-effective segmented spherical primary mirror combined with a unique wavefront sensing and control system that allows for continuous phasing of the primary mirror. The segmented spherical primary allows for cost-effective 3-meter class (eg, Midex and Discovery) missions as well as enables 30-meter telescope solutions that can be manufactured in a reasonable amount of time and for a reasonable amount of money. The continuous wavefront sensing and control architecture enables missions in low-earth-orbit and missions that do not require expensive stable structures and thermal control systems. For the 30-meter class applications, the paper discusses considerations for assembling and testing the telescopes in space. The paper also summarizes the scientific and technological roadmap for the architecture and also gives an overview of technology development, design studies, and testbed activities underway to demonstrate it s feasibility.

  9. Spherical Primary Optical Telescope (SPOT): An Architecture Demonstration for Cost-effective Large Space Telescopes

    NASA Technical Reports Server (NTRS)

    Feinberg, Lee D.; Hagopian, John; Budinoff, Jason; Dean, Bruce; Howard, Joe

    2004-01-01

    This paper summarizes efforts underway at the Goddard Space Flight Center to demonstrate a new type of space telescope architecture that builds on the rigid segmented telescope heritage of the James Webb Space Telescope but that solves several key challenges for future space telescopes. The architecture is based on a cost-effective segmented spherical primary mirror combined with a unique wavefront sensing and control system that allows for continuous phasing of the primary mirror. The segmented spherical primary allows for cost-effective 3-meter class (e.g., Midex and Discovery) missions as well as enables 30-meter telescope solutions that can be manufactured in a reasonable amount of time and for a reasonable amount of money. The continuous wavefront sensing and control architecture enables missions in low-earth-orbit and missions that do not require expensive stable structures and thermal control systems. For the 30-meter class applications, the paper discusses considerations for assembling and testing the telescopes in space. The paper also summarizes the scientific and technological roadmap for the architecture and also gives an overview of technology development, design studies, and testbed activities underway to demonstrate its feasibility.

  10. Direct Demonstration of the Concept of Unrestricted Effective-Medium Approximation

    NASA Technical Reports Server (NTRS)

    Mishchenko, Michael I.; Dlugach, Zhanna M.; Zakharova, Nadezhda T.

    2014-01-01

    The modified unrestricted effective-medium refractive index is defined as one that yields accurate values of a representative set of far-field scattering characteristics (including the scattering matrix) for an object made of randomly heterogeneous materials. We validate the concept of the modified unrestricted effective-medium refractive index by comparing numerically exact superposition T-matrix results for a spherical host randomly filled with a large number of identical small inclusions and Lorenz-Mie results for a homogeneous spherical counterpart. A remarkable quantitative agreement between the superposition T-matrix and Lorenz-Mie scattering matrices over the entire range of scattering angles demonstrates unequivocally that the modified unrestricted effective-medium refractive index is a sound (albeit still phenomenological) concept provided that the size parameter of the inclusions is sufficiently small and their number is sufficiently large. Furthermore, it appears that in cases when the concept of the modified unrestricted effective-medium refractive index works, its actual value is close to that predicted by the Maxwell-Garnett mixing rule.

  11. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L.

    1983-01-01

    An apparatus is described in which effects of pressure, volume, and temperature changes on a gas can be observed simultaneously. Includes use of the apparatus in demonstrating Boyle's, Gay-Lussac's, and Charles' Laws, attractive forces, Dalton's Law of Partial pressures, and in illustrating measurable vapor pressures of liquids and some solids.…

  12. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Cliche, Jean-Marie; And Others

    1988-01-01

    Describes two demonstrations: 1) the effect of polarity on solubility using sodium dichromate, TTE, ligroin, and water to form nonpolar-polar-nonpolar layers with the polar layer being colored; 2) determination of egg whites to be yellow by determining the content of yellow colored riboflavin in the egg white. (MVL)

  13. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Two demonstrations are described. The first shows the effect of polarity on solubility. The second is based on the unexpected formation of a precipitate of barium nitrate when barium carbonate or barium phosphate is treated with dilute nitric acid. List of materials needed and procedures used are included. (JN)

  14. Demonstrating Masculinity” Via Intimate Partner Aggression: The Moderating Effect of Heavy Episodic Drinking

    PubMed Central

    Lisco, Claire G.; Leone, Ruschelle M.; Gallagher, Kathryn E.; Parrott, Dominic J.

    2015-01-01

    The aim of the present study was to examine the mediational effect of masculine gender role stress on the relation between adherence to dimensions of a hegemonic masculinity and male-to-female intimate partner physical aggression. Men’s history of heavy episodic drinking was also examined as a moderator of the proposed mediation effect. A sample of 392 heterosexual men from the southeastern United States who had been in an intimate relationship within the past year completed measures of hegemonic masculine norms (i.e., status, toughness, and antifemininity), masculine gender role stress, alcohol use patterns, and intimate partner physical aggression. Results indicated that the indirect effects of adherence to the antifemininity and toughness norms on physical aggression toward female intimate partners via masculine gender role stress were significant and marginal, respectively. A significant indirect effect of status was not detected. Moreover, subsequent analyses revealed that the indirect effects of antifemininity and toughness were significant only among men with a history of heavy episodic drinking. These findings suggest that heavy episodic drinking exacerbates a gender-relevant stress pathway for intimate partner aggression among men who adhere to specific norms of masculinity. Overall, results suggest that the proximal effect of heavy episodic drinking focuses men’s attention on gender-based schemas associated with antifemininity and toughness, which facilitates partner-directed aggression as a means to demonstrate these aspects of their masculinity. Implications for the intersection between men’s adherence to specific norms of hegemonic masculinity, cognitive appraisal of gender relevant situations, and characteristic patterns of alcohol consumption are discussed. PMID:26456996

  15. Quantitative and empirical demonstration of the Matthew effect in a study of career longevity

    PubMed Central

    Petersen, Alexander M.; Jung, Woo-Sung; Yang, Jae-Suk; Stanley, H. Eugene

    2011-01-01

    The Matthew effect refers to the adage written some two-thousand years ago in the Gospel of St. Matthew: “For to all those who have, more will be given.” Even two millennia later, this idiom is used by sociologists to qualitatively describe the dynamics of individual progress and the interplay between status and reward. Quantitative studies of professional careers are traditionally limited by the difficulty in measuring progress and the lack of data on individual careers. However, in some professions, there are well-defined metrics that quantify career longevity, success, and prowess, which together contribute to the overall success rating for an individual employee. Here we demonstrate testable evidence of the age-old Matthew “rich get richer” effect, wherein the longevity and past success of an individual lead to a cumulative advantage in further developing his or her career. We develop an exactly solvable stochastic career progress model that quantitatively incorporates the Matthew effect and validate our model predictions for several competitive professions. We test our model on the careers of 400,000 scientists using data from six high-impact journals and further confirm our findings by testing the model on the careers of more than 20,000 athletes in four sports leagues. Our model highlights the importance of early career development, showing that many careers are stunted by the relative disadvantage associated with inexperience. PMID:21173276

  16. Demonstration of hetero-gate-dielectric tunneling field-effect transistors (HG TFETs)

    NASA Astrophysics Data System (ADS)

    Choi, Woo Young; Lee, Hyun Kook

    2016-06-01

    The steady scaling-down of semiconductor device for improving performance has been the most important issue among researchers. Recently, as low-power consumption becomes one of the most important requirements, there have been many researches about novel devices for low-power consumption. Though scaling supply voltage is the most effective way for low-power consumption, performance degradation is occurred for metal-oxide-semiconductor field-effect transistors (MOSFETs) when supply voltage is reduced because subthreshold swing (SS) of MOSFETs cannot be lower than 60 mV/dec. Thus, in this thesis, hetero-gate-dielectric tunneling field-effect transistors (HG TFETs) are investigated as one of the most promising alternatives to MOSFETs. By replacing source-side gate insulator with a high- k material, HG TFETs show higher on-current, suppressed ambipolar current and lower SS than conventional TFETs. Device design optimization through simulation was performed and fabrication based on simulation demonstrated that performance of HG TFETs were better than that of conventional TFETs. Especially, enlargement of gate insulator thickness while etching gate insulator at the source side was improved by introducing HF vapor etch process. In addition, the proposed HG TFETs showed higher performance than our previous results by changing structure of sidewall spacer by high- k etching process.

  17. Demonstration Results on the Effects of Mercury Speciation on the Stabilization of Wastes

    SciTech Connect

    Conley, T.B.; Hulet, G.A.; Morris, M.I.; Osborne-Lee, I.W.

    1999-06-01

    Mercury-contaminated wastes are currently being stored at approximately 19 Department of Energy sites, the volume of which is estimated to be about 16m(sup)3. These wastes exist in various forms including soil, sludges, and debris, which present a particular challenge regarding possible mercury stabilization methods. This reports provides the test results of three vendors, Allied Technology Group, IT Corporation, and Nuclear Fuel Services, Inc., that demonstrate the effects of mercury speciation on the stabilization of the mercury wastes. Mercury present in concentrations that exceed 260 parts per million must be removed by extraction methods and requires stabilization to ensure that the final wasteforms leach less than 0.2mg/L of mercury by the Toxicity Characteristic Leaching Procedure or 0.025 mg/L using the Universal Treatment Standard.

  18. Measurements of Forward Flight Effects on the Advanced Ducted Propulsion Demonstrator Engine

    NASA Technical Reports Server (NTRS)

    Horne, W. C.; Soderman, P. T.; Larkin, M.; Bock, L.; Olson, Lawrence (Technical Monitor)

    1994-01-01

    The performance of the Pratt & Whitney Advanced Ducted Propulsion (ADP) UHB concept has been recently evaluated with studies of a 17 in. diameter fan simulator. Following the model scale tests, a 118 in. diameter demonstrator was tested at the NASA Ames 40- by 80-Foot Wind Tunnel. The 18 blade fan was driven by the low compressor shaft of a PW2037 core through a reduction gear system fabricated by Fiat with approximately 1:3.7 reduction ratio. ne variable pitch fan was hydraulically actuated with settings for take-off, cruise, feather, and reverse thrust. The low-pressure turbine was built by MTU to provide higher shaft power in comparison with the standard PW2037. The demonstrator was provided with 45 vanes located 2.6 fan chords downstream of the rotor, and 10 case struts approximately 1 fan chord downstream of the vanes. The inlet, mid-duct, and exhaust linings were acoustically treated. Acoustic surveys were taken in the for-ward thrust mode for fan speeds of 898, 1120, 1205, and 1302 R.P.M., and at tunnel speeds of 25, 50, 100, and 140 kts. The lowest speed was achieved with the wind tunnel fans at flat pitch, but with the engine pumping the test section Microphone signals were recorded for 30 seconds at 5 deg. increments. These measurements will be used to assess the effects of forward speed on UHB engines, to compare these effects with the corresponding characteristics of conventional bypass ratio engines, and to discuss the various aspects of testing large engines in the wind tunnel.

  19. Demonstration Explosion

    NASA Astrophysics Data System (ADS)

    Lee, Charles "Skip"

    1998-05-01

    Last week I did a demonstration that produced a serious explosion. After putting methanol in a big glass carboy and rotating the carboy to build up some methanol vapor, I lit the mouth of the carboy. What normally happens is a "jet engine" effect out of the mouth of the carboy. In my case, the carboy exploded. Two polycarbonate blast shields were shattered and glass was blown as far as 15 feet away. I was not seriously cut and bruised, but had I not been using the two blast shields, I would have been severely injured. At this time, I am not sure what caused the explosion. I have done this demonstration around one hundred times with no problem using the exact same amount of methanol and technique. I think it is important to get the word out that this demonstration may be more dangerous than previously thought. I would also welcome any hypotheses concerning what caused the carboy to explode.

  20. ESWT and alendronate sodium demonstrate equal protective effects in osteoarthritis of the knee

    NASA Astrophysics Data System (ADS)

    Wang, Ching-Jen; Chou, Wen-Yi; Hsu, Shan-Ling; Huang, Chien-Yiu; Cheng, Jai-Hong

    2016-01-01

    This study compared the effects of extracorporeal shock wave therapy (ESWT) and alendronate sodium (alendronate) in osteoarthritis (OA) of rat knees. The control group was subjected to a sham surgery and did not receive either ESWT or alendronate treatment. The OA group underwent anterior cruciate ligament transection (ACLT) and medial meniscectomy (MM) surgery and did not receive either ESWT or alendronate. The ESWT group underwent ACLT and MM surgery and received ESWT after the surgery. The alendronate group received alendronate after ACLT and MM surgery. The evaluations included radiograph, bone mineral density (BMD), serum C-telopeptide collagen II (CTX-II), cartilage oligomeric protein (COMP), alkaline phosphatase and osteocalcin, histopathological examination and immunohistochemical analysis. Radiographs at 12 weeks showed pronounced OA changes in the OA group. The BMD values, CTX-II, COMP, alkaline phosphatase and osteocalcin showed no significant difference between ESWT and alendronate groups. In histopathology, the Mankin and Safranin O scores significantly increased in the OA, ESWT and alendronate groups, but without any significant difference between the ESWT and alendronate groups. In immunohistochemical analysis, the von Willebrand factor (vWF), vascular endothelial factor (VEGF), soluble vascular cell adhesion molecule (sVCAM), proliferating cell nuclear antigen (PCNA), bone morphogenetic protein 2 (BMP-2), and osteocalcin expressions in articular cartilage and subchondral bone showed a significant decrease in the OA group, but no difference was noted between the ESWT and alendronate groups. In conclusion, ESWT and alendronate sodium demonstrate equal protective effects from developing osteoarthritis of the knee in rats.

  1. The discovery of the Mach reflection effect and its demonstration in an auditorium

    NASA Astrophysics Data System (ADS)

    Krehl, P.; van der Geest, M.

    1991-03-01

    This paper examines the historical background leading to the discovery of the Mach reflection effect and applies original documents from Mach's residue which are kept in the archives of the Ernst-Mach-Institut in Freiburg. Two experimental setups for the generation and demonstration of the Mach reflection effect, incorporating an overhead projector, are described: (a) Mach's historic mechanical shock wave reflection and interaction experiments with soot covered glass plates, performed in 1875. The Mach triple points sharply erase the soot which results in a residual picture of funnel-shaped V-formations. The head-on collision of two shock waves is marked as a narrow line of piled-up soot. (b) CalTech's hydraulic jump reflection experiments in a shallow ripple tank, performed during World War II. Regular reflection and its transition into a Mach reflection wave. Using a slightly inclined tank and providing a “shoreline” in the middle of the tank, Mach stem propagation slows down to zero when hitting the shore line and, therefore, can be observed “live” without the use of a slow motion technique.

  2. CubeSat Measurement and Demonstration of Coulomb Drag Effect for Deorbiting

    NASA Astrophysics Data System (ADS)

    2013-08-01

    Deorbiting satellites by passive or active electrodynamic tether Lorentz force effect is well known. Probably less well known is that a charged conducting tether also interacts with the streaming ionospheric plasma by electrostatic Coulomb drag. Especially for the case of small satellites deorbited by thin tethers, the Coulomb drag effect can be larger than the Lorentz force effect. When a tether is optimised for Coulomb drag, the goal is only to keep it charged. The fact that the charged tether gathers current is then a side effect which can be minimised by using negative voltage and by making the tether very thin. Using negative voltage in most cases implies that one can use the satellite's conducting surface as the other electrode so that no electron or ion emitter is needed on the spacecraft for closing the circuit. Thinness of the tether is a large benefit not only from the mass saving and power consumption minimisation points of view, but also because a sufficiently thin tether (made e.g. four 25-50 micrometre thin aluminium wires) poses nearly no threat to other space assets in the even of an unwanted collision. ESTCube-1 is an Estonian 1U CubeSat which is scheduled for Vega launch in May 2013 to 680 km polar orbit. The payload of ESTCube-1 is a 10 m long Heytether made of 25-50 aluminium wires which can be charged to plus orminus 500 V by onboard voltage sources and electron gun. The mission of ESTCube-1 is to demonstrate deployment of very thin multiline (and thus micrometeoroid tolerant) tether and to measure the Coulomb drag effect on the charged tether by ionospheric plasma ram flow. The Coulomb drag has not been measured before and besides useful for deorbiting the effect can also be used to propel interplanetary spacecraft by the fast moving solar wind plasma stream. The measurement of the micronewton scale force is carried out by turning the voltage on and off in a synchronous way with the satellite's rotation and by measuring the cumulative change

  3. The Fort McMurray Demonstration Project in Social Marketing: no demonstrable effect on already falling injury rates following intensive community and workplace intervention.

    PubMed

    Guidotti, Tee L; Deb, Pooja; Bertera, Robert; Ford, Lynda

    2009-10-01

    The Fort McMurray Demonstration Project in Social Marketing attempted to achieve mutually reinforcing effects from thematically coordinated educational and awareness efforts in the community as a whole and in the workplace and the inclusion of occupational safety within the framework of a community health promotion project. The study community was Fort McMurray, a small, industrial city in northern Alberta. The Mistahiai Health Region, several hundred kilometers to the west and also dominated by one city, Grande Prairie, served as the reference community. The intervention was based on media and events staged at public events, with supporting educational activities in schools and the community. It relied heavily on community-based partners and volunteers. Data on healthcare utilization of selected preventable injuries were obtained from Alberta Health for the time period 1990-1996 for the Regional Health Authorities of Northern Lights, where the only large population centre is Fort McMurray, and Mistahia. Age-adjusted aggregate injury rates were analyzed for evidence of an effect of the intervention. Severity was measured by proxy, using the number of diagnostic claims submitted for reimbursement for medical services in a given year. The communities differed in age-specific injury rates, with Fort McMurray showing higher rates for residents aged less than 55. Young adults and older adolescents showed higher levels of severity. Injury rates fell substantially and at similar rates in both communities over the five-year period. However, in both communities injury rates were already falling before the intervention in Fort McMurray began and continued to fall at about the same rate, slowing toward the end of the period. No evidence was found for an effect of the Project or for acceleration of the reduction in injury frequency in the intervention area. Over the period, fewer medical services were delivered in office settings and more in emergency rooms, in both

  4. Effectiveness of a publicly-funded demonstration program to promote management of dryland salinity.

    PubMed

    Robertson, M J; Measham, T G; Batchelor, G; George, R; Kingwell, R; Hosking, K

    2009-07-01

    Community and catchment-based approaches to salinity management continue to attract interest in Australia. In one such approach, Catchment Demonstration Initiative (CDI) projects were established by the Western Australian (WA) Government in 2000 for targeted investment in large-scale catchment-based demonstrations of integrated salinity management practices. The aim was to promote a process for technically-informed salinity management by landholders. This paper offers an evaluation of the effectiveness of one CDI project in the central wheatbelt of WA, covering issues including: its role in fostering adoption of salinity management options, the role of research and the technical requirements for design and implementation of on-ground works, the role of monitoring and evaluation, the identification and measurement of public and private benefits, comparison and identification of the place and value of plant-based and engineering-based options, reliance on social processes and impacts of constraints on capacity, management of governance and administration requirements and an appreciation of the value of group-based approaches. A number of factors may reduce the effectiveness of CDI-type approaches in facilitating landholder action to address salinity, many of these are socially-based. Such approaches can create considerable demands on landholders, can be expensive (because of the planning and accountability required) on the basis of dollars per hectare impacted, and can be difficult to garner ownership from all involved. An additional problem could be that few community groups would have the capacity to run such programs and disseminate the new knowledge so that the CDI-type projects can impact outside the focus catchment. In common with many publicly-funded approaches to salinity, we found that direct benefits on public assets are smaller than planned and that results from science-based requirements of monitoring and evaluation have long lead times, causing farmers

  5. 77 FR 37059 - Draft Guidance for Industry on Active Controls in Studies To Demonstrate Effectiveness of a New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... Demonstrate Effectiveness of a New Animal Drug for Use in Companion Animals; Availability AGENCY: Food and... Demonstrate Effectiveness of a New Animal Drug for Use in Companion Animals.'' This draft guidance advises... of new animal drugs for use in companion animals. The intent of the guidance is to...

  6. Effectiveness of Demonstration and Lecture Methods in Learning Concept in Economics among Secondary School Students in Borno State, Nigeria

    ERIC Educational Resources Information Center

    Muhammad, Amin Umar; Bala, Dauda; Ladu, Kolomi Mutah

    2016-01-01

    This study investigated the Effectiveness of Demonstration and Lecture Methods in Learning concepts in Economics among Secondary School Students in Borno state, Nigeria. Five objectives: to determine the effectiveness of demonstration method in learning economics concepts among secondary school students in Borno state, determine the effectiveness…

  7. Demonstration of high current carbon nanotube enabled vertical organic field effect transistors at industrially relevant voltages

    NASA Astrophysics Data System (ADS)

    McCarthy, Mitchell

    The display market is presently dominated by the active matrix liquid crystal display (LCD). However, the active matrix organic light emitting diode (AMOLED) display is argued to become the successor to the LCD, and is already beginning its way into the market, mainly in small size displays. But, for AMOLED technology to become comparable in market share to LCD, larger size displays must become available at a competitive price with their LCD counterparts. A major issue preventing low-cost large AMOLED displays is the thin-film transistor (TFT) technology. Unlike the voltage driven LCD, the OLEDs in the AMOLED display are current driven. Because of this, the mature amorphous silicon TFT backplane technology used in the LCD must be upgraded to a material possessing a higher mobility. Polycrystalline silicon and transparent oxide TFT technologies are being considered to fill this need. But these technologies bring with them significant manufacturing complexity and cost concerns. Carbon nanotube enabled vertical organic field effect transistors (CN-VFETs) offer a unique solution to this problem (now known as the AMOLED backplane problem). The CN-VFET allows the use of organic semiconductors to be used for the semiconductor layer. Organics are known for their low-cost large area processing compatibility. Although the mobility of the best organics is only comparable to that of amorphous silicon, the CN-VFET makes up for this by orienting the channel vertically, as opposed to horizontally (like in conventional TFTs). This allows the CN-VFET to achieve sub-micron channel lengths without expensive high resolution patterning. Additionally, because the CN-VFET can be easily converted into a light emitting transistor (called the carbon nanotube enabled vertical organic light emitting transistor---CN-VOLET) by essentially stacking an OLED on top of the CN-VFET, more potential benefits can be realized. These potential benefits include, increased aperture ratio, increased OLED

  8. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for two demonstrations are presented. The first is a demonstration of chemiluminescence. The second is a demonstration using a secondary battery constructed from common household articles. (JN)

  9. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1978-01-01

    Presents the following chemistry lecture demonstrations and experiments: (1) a versatile kinetic demonstration; (2) the Bakelite Demonstration; (3) applying Beer's law; and (4) entropy calculations. (HM)

  10. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1979-01-01

    Presents two demonstrations which are intended for chemistry college students. These demonstrations are: (1) enhancement of concentration quenching by micelles; and (2) the thermite lecture demonstration. (HM)

  11. Apparatus for the demonstration of superconductivity at liquid nitrogen temperature by means of Meissner effect

    SciTech Connect

    McSharry, W.O.; Phillips, J.E.

    1988-09-15

    One property of superconductive materials, the exclusion of a magnetic field, or Meissner effect, can be observed with only a magnet and a refrigeration source. Levitation of a cooled pellet of superconducting material above a magnet or levitation of a magnet above the superconducting material is commonly used as a means of demonstrating the presence of a superconductor. If the applied magnetic field is strong enough relative to the amount of superconductive material present in the sample, levitation can be observed. However, if the fraction of superconductor in the pellet is not great enough to overcome the force of gravity, the repulsive force may not be apparent without sensitive equipment. If the material is a powder, a superconductor may be detected by sprinkling the powder into a container of liquid nitrogen with a magnet in or beneath it. The superconducting material avoids the region of high magnetic flux, leaving a bare spot. According to the authors, 2% of superconducting powder admixed with inert copper oxide can be detected in this way. This method requires the use of only simple, inexpensive equipment that, except for the liquid nitrogen, is likely to be available in most laboratories. It will by useful for the detection of superconductivity in known compounds.

  12. Direct effects of ethane dimethanesulphonate on epididymal function in adult rats. An in vitro demonstration

    SciTech Connect

    Klinefelter, G.L.; Roberts, N.L.; Suarez, J.D.

    1992-01-01

    It was recently demonstrated that the Leydig cell toxicant ethane dimethanesulphonate (EDS) produces multiple effects on the epididymis after a single in vivo exposure. To determine whether any of the perturbations were mediated by a direct action of the compound, we used a novel system for the coculture of epididymal epithelial cells and sperm from the caput epididymidis. This system maintains the morphologic integrity and cell polarity of the epididymal epithelial cells before and during coculture, and the sperm recovered after coculture have intact plasma and acrosomal membranes. In addition, several functions required for epididymal sperm maturation are expressed, including the secretion of protein by the epididymal epithelium, the association of secreted protein with the plasma membrane of cocultured sperm, and the acquisition of progressive motility by cocultured sperm. In vitro exposure of epididymal epithelial cells and sperm to EDS results in a significant decline in protein secretion by the epithelial cells during coculture, and in particular, a dose-dependent decline in a 36- to 38-kd protein (PI 4.0 to 4.5) and a 34- to 36-kd protein (PI 4.5 to 5.0). Moreover, these and other proteins are not recovered from the sperm membrane of cocultured sperm after EDS treatment. Finally, EDS results in a dose-dependent decline in the percentage of both motile and progressively motile sperm recovered after coculture compared with that of sperm from untreated cocultures.

  13. Major Effects of Nonmetallic Inclusions on the Fatigue Life of Disk Superalloy Demonstrated

    NASA Technical Reports Server (NTRS)

    Gabb, Timothy P.; Telesman, Jack; Kantzos, Peter T.; Bonacuse, Peter J.; Barrie, Robert L.

    2002-01-01

    then sealed in separate containers, hot isostatically pressurized, extruded, forged into subscale disks, and heat treated. Low-cycle-fatigue specimens were then extracted, machined, and tested. Fatigue tests were performed at 650 C in closed-loop servohydraulic testing machines using induction heating and axial extensometers. All tests were continued to failure, and fractographic evaluations were performed on all specimens to determine the crack initiation sites. A large majority of the failures in specimens with introduced inclusions occurred at cracks initiating from inclusions at the specimen surface, as shown for each type of inclusion in the following bar chart. The inclusions significantly reduced fatigue life from unseeded material levels, as shown in the bar chart. These effects were found to depend on the strain range, strain ratio, and inclusion size. Tests at lower strain ranges and higher strain ratios resulted in larger effects of inclusions on life. Inclusion effects on life were thereby maximized in tests at the lowest strain range of 0.6 percent and the most positive strain ratio of 0.5. Under these conditions, small Type 2 inclusions reduced life substantially-- about 20 times, whereas large Type 1 inclusions dramatically reduced life 100 times. These results clearly demonstrate that it is essential to include the effects of inclusions for realistic predictions of disk fatigue life. Important issues, including temperature dependence, crack initiation versus propagation, surface treatments, realistic disk features and machining, and realistic disk spin testing will be addressed to accurately model inclusion effects on disk fatigue life. Fatigue life varied from well over 105 cycles for no inclusions to a little over 103 cycles for 100-micrometer inclusions. A single crack initiating at a surface-connected seeded inclusion caused failure in each case.

  14. Notes: Water Flow and Chemical Retardation in Soils: A Simple Effective Laboratory Demonstration.

    ERIC Educational Resources Information Center

    Bowman, R. S.; And Others

    1988-01-01

    Describes a laboratory demonstration that illustrates principles of miscible displacement and chemical retardation in soils. Discusses how the experimental apparatus can be constructed from readily available materials. (TW)

  15. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1988-01-01

    Details three demonstrations for use in chemistry classrooms. Includes: "A Demonstration of Corrosion by Differential Aeration"; "A Simple Demonstration of the Activation Energy Concept"; and "A Boiling Demonstration at Room Temperature." Each description includes equipment, materials, and methods. (CW)

  16. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1988-01-01

    Describes two chemistry demonstrations including a demonstration of chemical inhibition and "The Rayleigh Fountain" which demonstrates the polarity of the water molecule. Provides instructions and explanations for each demonstration. (CW)

  17. A Palatable Introduction to and Demonstration of Statistical Main Effects and Interactions

    ERIC Educational Resources Information Center

    Christopher, Andrew N.; Marek, Pam

    2009-01-01

    Because concrete explanations in a familiar context facilitate understanding, we illustrate the concept of an interaction via a baking analogy to provide students with food for thought. The demonstration initially introduces the concepts of independent and dependent variables using a chocolate chip cookie recipe. The demonstration provides an…

  18. Effect of Dialogue on Demonstrations: Direct Quotations, Facial Portrayals, Hand Gestures, and Figurative References

    ERIC Educational Resources Information Center

    Bavelas, Janet; Gerwing, Jennifer; Healing, Sara

    2014-01-01

    "Demonstrations" (e.g., direct quotations, conversational facial portrayals, conversational hand gestures, and figurative references) lack conventional meanings, relying instead on a resemblance to their referent. Two experiments tested our theory that demonstrations are a class of communicative acts that speakers are more likely to use…

  19. USTUR WHOLE BODY CASE 0269: DEMONSTRATING EFFECTIVENESS OF I.V. CA-DTPA FOR PU

    SciTech Connect

    James, Anthony C.; Sasser , Lyle B.; Stuit, Dorothy B.; Glover, Samuel E.; Carbaugh, Eugene H.

    2008-01-28

    This whole body donation case (USTUR Registrant) involved a single acute inhalation of an acidic Pu(NO3)4 solution in the form of an aerosol ‘mist.’ Chelation treatment with i.v. Ca-EDTA was initiated on the day of the intake, and continued intermittently over 6 months. After 2½ years with no further treatment, a course of i.v. Ca-DTPA was administered. A total of 400 measurements of 239+240Pu excreted in urine were recorded; starting on the first day (both before and during the initial Ca-EDTA chelation), and continuing for 37 years. This sampling included all intervals of chelation. In addition, 91 measurements of 239+240Pu-in-feces were recorded over this whole period. The Registrant died about 38 years after the intake, at age 79 y, with extensive carcinomatosis secondary to adenocarcinoma of the prostate gland. At autopsy, all major soft tissue organs were harvested for radiochemical analyses of their 238Pu, 239+240Pu and 241Am content. Also, all types of bone (comprising about half the skeleton) were harvested for radiochemical analyses, as well as samples of skin, subcutaneous fat and muscle. This comprehensive dataset has been applied to derive ‘chelation-enhanced’ transfer rates in the ICRP Publication 67 plutonium biokinetic model, representing the behaviour of blood-borne and tissue-incorporated plutonium during intervals of therapy. The resulting model of the separate effects of i.v. Ca-EDTA and Ca-DTPA chelation shows that the therapy administered in this case succeeded in reducing substantially the long-term burden of plutonium in all body organs, except for the lungs. The calculated reductions in organ content at the time of death are approximately 40% for the liver, 60% for other soft tissues (muscle, skin, glands, etc.), 50% for the kidneys, and 50% for the skeleton. Essentially all of the substantial reduction in skeletal burden occurred in trabecular bone. This modeling exercise demonstrated that 3-y-delayed Ca-DTPA therapy was as

  20. How-To-Do-It: Environmental Pollution Effects Demonstrated by Metal Adsorption in Lichens.

    ERIC Educational Resources Information Center

    Miller, James E.

    1988-01-01

    Presents an experiment to demonstrate the degree to which environmental cations are taken up by susceptible lichen organisms in the field. Discusses the preparation of materials, procedures and typical results for this short laboratory exercise. (CW)

  1. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1988-01-01

    Describes three flame test demonstrations including "Student-Presented Demonstrations on the Colors of Transition Metal Complexes,""A Flame Test Demonstration Device," and "Vivid Flame Tests." Preparation and procedures are discussed. Included in the first demonstration is an evaluation scheme for grading student demonstrations. (CW)

  2. [Thinking and Methods for Demonstrating the Effectiveness of Chinese Herbal Compounds from the Perspective of Pharmacokinetics].

    PubMed

    Su, Ru-yu; Zhang, Lei; Zhang, Yu; Yan, Rong; Hou, Xue-qin; Qu, Zhao; Yang, Cong; Chen, Yun-bo; Wang, Qi

    2016-01-01

    To exert pharmacological effects, no matter therapeutic effect or toxic/side effect, it's necessary to achieve enough plasma concentration. Chinese medical compounds, which contain various ingredients, influence the metabolism of some active ingredients through the interaction of ingredients to improve curative effects or reduce toxic/side effects. Pharmacokinetics can be used to explore how Chinese medical compounds influence the in vivo metabolism of some active ingredients to achieve better curative effects. PMID:26955690

  3. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Presented are three demonstrations for chemical education. The activities include: (1) demonstration of vapor pressure; (2) a multicolored luminol-based chemiluminescence demonstration; and (3) a Charles's Law/Vapor pressure apparatus. (RH)

  4. Reflectance Demonstration.

    ERIC Educational Resources Information Center

    Kowalski, Frank

    1993-01-01

    Presents a demonstration in which a mirror "disappears" upon rotation. The author has used the demonstration with students from fourth grade up through college. Suggestions are given for making the demonstration into a permanent hallway display. (MVL)

  5. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1982-01-01

    Three chemistry demonstrations are described: (1) partition coefficients; (2) Rutherford simulation experiment; and (3) demonstration of the powerful oxidizing property of dimanganeseheptoxide. Background information, materials needed, and procedures are provided for each demonstration. (JN)

  6. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1981-01-01

    Provides procedures for demonstrations: (1) the ferrioxalate actinometer, which demonstrates a photochemical reaction; and (2) the silver mirror, which demonstrates the reduction of a metal salt to the metal and/or the reducing power of sugars. (CS)

  7. Detection of African animal trypanosomes: the haematocrit centrifugation technique compared to PCR with samples stored on filter paper or in DNA protecting buffer.

    PubMed

    Moti, Y; Fikru, R; Büscher, P; Van Den Abbeele, J; Duchateau, L; Delespaux, V

    2014-07-14

    The present study aimed at comparing the trypanosome specific 18S-PCR-RFLP using samples stored either on Whatman filter papers (PCR-RFLP-fp) or in a commercial cell lysis and DNA protecting buffer (PCR-RFLP-pb) with the haematocrit centrifugation technique (HCT), a method widely used for the diagnosis of African Animal Trypanosomosis. Out of 411 head of cattle, 49 (11.92%) (CI=8.95-15.45) scored positive for the presence of trypanosomes by HCT whereas 75 (18.25%) (CI=14.63-22.33) and 124 (30.17%) (CI=25.77-34.86) scored positive using PCR-RFLP-fp and PCR-RFLP-pb, respectively. Out of the 49 positives by HCT, 14 (28.57%) (CI=16.58-43.26) and 28 (57.14%) (CI=42.21-71.18) were concordant by PCR-RFLP-fp and PCR-RFLP-pb, respectively. None of the PCR techniques detected parasites from the Trypanozoon group. Although HCT detected more cases of Trypanosoma vivax (33), species identification using PCR-RFLP-fp and PCR-RFLP-pb were significantly different (p<0.001) from the HCT technique. The use of DNA protective buffer is thus recommended as the output of the PCR-RFLP-pb is improved and the risk of contamination between samples is reduced. PMID:24836424

  8. An Easy and Effective Demonstration of Enzyme Stereospecificity and Equilibrium Thermodynamics

    ERIC Educational Resources Information Center

    Herdman, Chelsea; Dickman, Michael

    2011-01-01

    Enzyme stereospecificity and equilibrium thermodynamics can be demonstrated using the coupling of two amino acid derivatives by Thermoase C160. This protease will catalyze peptide bond formation between Z-L-AspOH and L-PheOMe to form the Aspartame precursor Z-L-Asp-L-PheOMe. Reaction completion manifests itself by precipitation of the product. As…

  9. Demonstrating the Effect of Interphase Mass Transfer in a Transparent Fluidized Bed Reactor

    ERIC Educational Resources Information Center

    Saayman, Jean; Nicol, Willie

    2011-01-01

    A demonstration experiment is described that employs the ozone decomposition reaction at ambient conditions on Fe2O3 impregnated Fluidized Catalytic Cracking (FCC) catalyst. Using a two-dimensional see-through column the importance of interphase mass transfer is clearly illustrated by the significant difference in ozone conversion between the…

  10. Salience and Contrast Effects in Reference Resolution: The Interpretation of Dutch Pronouns and Demonstratives

    ERIC Educational Resources Information Center

    Kaiser, Elsi

    2011-01-01

    We report three experiments on reference resolution in Dutch. The results of two off-line experiments and an eye-tracking study suggest that the interpretation of different referential forms--in particular, "emphatic" strong pronouns, weak pronouns, and demonstrative pronouns--cannot be satisfactorily explained in terms of a single feature of the…

  11. Silicon Carbide Junction Field Effect Transistor Digital Logic Gates Demonstrated at 600 deg. C

    NASA Technical Reports Server (NTRS)

    Neudeck, Philip G.

    1998-01-01

    The High Temperature Integrated Electronics and Sensors (HTIES) Program at the NASA Lewis Research Center is currently developing silicon carbide (SiC) for use in harsh conditions where silicon, the semiconductor used in nearly all of today's electronics, cannot function. The HTIES team recently fabricated and demonstrated the first semiconductor digital logic gates ever to function at 600 C.

  12. Supported Work Demonstration: Effects During the First 18 Months after Enrollment.

    ERIC Educational Resources Information Center

    Maynard, Rebecca; And Others

    An interim evaluation was conducted to determine the impact of the National Supported Work Demonstration (NSWD) on employment of four target groups: Aid for Dependent Children (AFDC) recipients, ex-drug-addicts, ex-offenders, and youths. The evaluation was based on data collected in interviews with 2,830 persons--1,419 of whom were offered…

  13. Tested Demonstrations

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1977-01-01

    Three demonstrations are described: paramagnetic properties of Fe(11) and Fe(111), the preparation of polyurethane foam: a lecture demonstration and the electrolysis of water-fuel cell reactions. A small discussion of the concepts demonstrated is included in each demonstration's description. (MR)

  14. The Principle of Equivalence: Demonstrations of Local Effective Vertical and Horizontal

    ERIC Educational Resources Information Center

    Munera, Hector A.

    2010-01-01

    It has been suggested that Einstein's principle of equivalence (PE) should be introduced at an early stage. This principle leads to the notion of local effective gravity, which in turn defines effective vertical and horizontal directions. Local effective gravity need not coincide with the direction of terrestrial gravity. This paper describes…

  15. Experimental demonstration of nonlocal effects in the partial-collapse measurement and reversal process

    SciTech Connect

    Xu Xiaoye; Xu Jinshi; Li Chuanfeng; Zou Yang; Guo Guangcan

    2011-01-15

    We demonstrate experimentally the nonlocal reversal of a partial-collapse quantum measurement of a two-photon entangled state. Both the partial-collapse measurement and the reversal operation are implemented in linear optics with two displaced Sagnac interferometers, characterized by single-qubit quantum-process tomography. The recovered state is measured by quantum-state tomography, and its nonlocality is characterized by testing the Bell inequality. Our result will be helpful in quantum communication and quantum error correction.

  16. Organic Lecture Demonstrations of Common-Ion Effect, Ionizing Power of Solvents, and First-Order Reaction Kinetics.

    ERIC Educational Resources Information Center

    Danen, Wayne C.; Blecha, M. Therese, Sr.

    1982-01-01

    Background information and experimental procedures are provided for three lecture-demonstrations (involving hydrolysis of tetra-butyl chloride) illustrating: (1) common-ion or mass law effect; (2) effect of changing ionizing power of a solvent on a solvolysis reaction; and (3) collecting/plotting data to illustrate a first-order reaction.…

  17. 78 FR 63477 - Guidance for Industry on Active Controls in Studies To Demonstrate Effectiveness of a New Animal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... INFORMATION: I. Background In the Federal Register of June 20, 2012 (77 FR 37059), FDA published the notice of... Demonstrate Effectiveness of a New Animal Drug for Use in Companion Animals; Availability AGENCY: Food and... Effectiveness of a New Animal Drug for Use in Companion Animals.'' This guidance advises industry on the use...

  18. Light and Plants. A Series of Experiments Demonstrating Light Effects on Seed Germination, Plant Growth, and Plant Development.

    ERIC Educational Resources Information Center

    Downs, R. J.; And Others

    A brief summary of the effects of light on plant germination, growth and development, including photoperiodism and pigment formation, introduces 18 experiments and demonstrations which illustrate aspects of these effects. Detailed procedures for each exercise are given, the expected results outlined, and possible sources of difficulty discussed.…

  19. Pitfalls in Evaluating the Effectiveness of Case Management Programs for Homeless Persons: Lessons from the NIAAA Community Demonstration Program.

    ERIC Educational Resources Information Center

    Orwin, Robert G.; And Others

    1994-01-01

    Evaluation findings of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Community Demonstration Program show few clear indications of the effectiveness of case management approaches. This article identifies phenomena that explain the lack of positive effects and suggests that evaluation problems may explain apparent negative…

  20. A Laboratory to Demonstrate the Effect of Thermal History on Semicrystalline Polymers Using Rapid Scanning Rate Differential Scanning Calorimetry

    ERIC Educational Resources Information Center

    Badrinarayanan, Prashanth; Kessler, Michael R.

    2010-01-01

    A detailed understanding of the effect of thermal history on the thermal properties of semicrystalline polymers is essential for materials scientists and engineers. In this article, we describe a materials science laboratory to demonstrate the effect of parameters such as heating rate and isothermal annealing conditions on the thermal behavior of…

  1. 30 CFR 1243.12 - May I substitute a demonstration of financial solvency for a bond posted before the effective...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... solvency for a bond posted before the effective date of this rule? 1243.12 Section 1243.12 Mineral... May I substitute a demonstration of financial solvency for a bond posted before the effective date of this rule? If you appealed an order before June 14, 1999 and you submitted an ONRR-specified...

  2. Cost-Effectiveness Analysis of Early Reading Programs: A Demonstration with Recommendations for Future Research

    ERIC Educational Resources Information Center

    Hollands, Fiona M.; Kieffer, Michael J.; Shand, Robert; Pan, Yilin; Cheng, Henan; Levin, Henry M.

    2016-01-01

    We review the value of cost-effectiveness analysis for evaluation and decision making with respect to educational programs and discuss its application to early reading interventions. We describe the conditions for a rigorous cost-effectiveness analysis and illustrate the challenges of applying the method in practice, providing examples of programs…

  3. The Effect of Initial Conditions and Discussion on Students' Predictions for Interactive Lecture Demonstrations

    NASA Astrophysics Data System (ADS)

    Marx, Jeffrey

    2008-10-01

    Over the past eight years at McDaniel College, students' Predictions for various Interactive Lecture Demonstrations (ILDs) have improved markedly. One explanation is that students have become increasingly sophisticated in their understanding of kinematics and dynamics. Another possible explanation is that the class as a whole is only slightly more sophisticated, and during the Discussion Phase of the ILD the correct Predication is very successfully transmitted within groups and between groups. The purpose of this paper is to support the proposition of this possible explanation. To begin to address this idea, I present an overview of and results from a preliminary, computer-based simulation of classroom discussion.

  4. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Provides instructions on conducting four demonstrations for the chemistry classroom. Outlines procedures for demonstrations dealing with coupled oscillations, the evaporation of liquids, thioxanthone sulfone radical anion, and the control of variables and conservation of matter. (TW)

  5. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1990-01-01

    Presented are two demonstrations; "Heat of Solution and Colligative Properties: An Illustration of Enthalpy and Entropy," and "A Vapor Pressure Demonstration." Included are lists of materials and experimental procedures. Apparatus needed are illustrated. (CW)

  6. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1978-01-01

    Presents two demonstrations; one on Boyle's Law, to illustrate the gas law and serve as a challenging problem for the students; the other is a modified Color Blind Traffic Light demonstration in which the oscillating reactions were speeded up. (GA)

  7. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1978-01-01

    Two demonstrations are described which are suitable for introductory chemistry classes. The first involves the precipitation of silver, and the second is a demonstration of the relationship between rate constants and equilibrium constants using water and beakers. (BB)

  8. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1989-01-01

    Presented are two demonstrations including a variation of the iodine clock reaction, and a simple demonstration of refractive index. The materials, procedures, and a discussion of probable results are given for each. (CW)

  9. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1981-01-01

    Two demonstrations are described: (1) red cabbage and electrolysis of water to bring together acid/base and electrochemical concepts; and (2) a model to demonstrate acid/base conjugate pairs utilizing magnets. (SK)

  10. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1988-01-01

    Describes two demonstrations for college level chemistry courses including: "Electrochemical Cells Using Sodium Silicate" and "A Simple, Vivid Demonstration of Selective Precipitation." Lists materials, preparation, procedures, and precautions. (CW)

  11. Demonstration of a quasi-scalar angular Goos-Hänchen effect.

    PubMed

    Merano, M; Hermosa, N; Aiello, A; Woerdman, J P

    2010-11-01

    We show experimentally that the angular Goos-Hänchen (GH) effect can be easily observed, also without employing its resonant enhancement at Brewster incidence. An s-polarized beam was used to decouple the polarization from the propagation dynamics of the beam. We found that, in this case, the angular GH effect can be strongly enhanced by increasing the angular aperture of the Gaussian beam. Our experiments suggest a route toward observing the angular GH effect for true scalar waves, such as acoustic waves and quantum matter waves. PMID:21042350

  12. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1986-01-01

    Describes a demonstration involving the controlled combustion of a mixture of metals with black and smokeless powder in a small Erlenmeyer flask. Also describes demonstrations using a device that precludes breathing of hazardous vapors during class demonstrations; the device is easy to transport and use in rooms without sinks. (JN)

  13. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Describes two classroom chemistry demonstrations which focus on the descriptive chemistry of bromine and iodine. Outlines the chemicals and equipment needed, experimental procedures, and discussion of one demonstration of the oxidation states of bromine and iodine, and another demonstration of the oxidation states of iodine. (TW)

  14. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Sands, Robert; And Others

    1982-01-01

    Procedures for two demonstrations are provided. The solubility of ammonia gas in water is demonstrated by introducing water into a closed can filled with the gas, collapsing the can. The second demonstration relates scale of standard reduction potentials to observed behavior of metals in reactions with hydrogen to produce hydrogen gas. (Author/JN)

  15. Demonstrating Diffusion

    ERIC Educational Resources Information Center

    Foy, Barry G.

    1977-01-01

    Two demonstrations are described. Materials and instructions for demonstrating movement of molecules into cytoplasm using agar blocks, phenolphthalein, and sodium hydroxide are given. A simple method for demonstrating that the rate of diffusion of a gas is inversely proportional to its molecular weight is also presented. (AJ)

  16. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1985-01-01

    List of materials needed, procedures used, and results obtained are provided for two demonstrations. The first is an inexpensive and quick method for demonstrating column chromatography of plant pigments of spinach extract. The second is a demonstration of cathodic protection by impressed current. (JN)

  17. How-to-Do-It: Demonstrating the Effects of Stress on Cellular Membranes.

    ERIC Educational Resources Information Center

    Vodopich, Darrell S.; Moore, Randy

    1989-01-01

    Describes two simple procedures allowing students to experiment with living membranes and to relate their results to fundamental membrane structure. Provides instructions for determining the effects of temperature and organic solvent stress on cellular membranes, and spectrophotometric analysis. (RT)

  18. 76 FR 10038 - Determination That a Demonstration Needle Exchange Program Would be Effective in Reducing Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... Drug Abuse and the Risk of Acquired Immune Deficiency Syndrome Infection Among Intravenous Drug Users... program or SSP) would be effective in reducing drug abuse and the risk of infection with the...

  19. The effect of science demonstrations as a community service activity on pre-service science teachers' teaching practices

    NASA Astrophysics Data System (ADS)

    Gurel, Derya Kaltakci

    2016-03-01

    In the scope of this study, pre-service science teachers (PSST) developed and carried out science demonstrations with everyday materials for elementary school students as a community service activity. 17 PSST enrolled in the community services practices course at Kocaeli University comprised the sample of the present study. Community service practices aim to develop consciousness of social responsibility and professional skills, as well as to gain awareness of social and community problems and find solutions for pre-service teachers. With this aim, each PSST developed five science demonstration activities and their brochures during a semester. At the end of the semester, a total of 85 demonstrations were carried out at public elementary schools, which are especially located in socioeconomically poor districts of Kocaeli, Turkey. In the present case study, the effect of developing and carrying out science demonstrations for elementary school students on six of the PSST' teaching practices on density and buoyancy concept was investigated. 30-minute interviews conducted with each PSST, videos recorded during their demonstration performances, brochures they prepared for their demonstration activities, and reflection papers were used as data collection tools of the study. The results showed that community service practices with science demonstrations had positive effects on PSST' science content knowledge and pedagogical content knowledge.

  20. Experimental demonstration of the stabilizing effect of dielectric coatings on magnetically accelerated imploding metallic liners

    DOE PAGESBeta

    Awe, Thomas James; Peterson, Kyle J.; Yu, Edmund P.; McBride, Ryan D.; Sinars, Daniel B.; Gomez, Matthew R.; Jennings, Christopher Ashley; Martin, Matthew R.; Rosenthal, Stephen E.; Sefkow, Adam B.; et al

    2016-02-10

    Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70 μm of dielectric. The dielectric tamps liner-mass redistribution from electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio [CR=Rin,0/Rin(z,t)] of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. Lastly, the inner-wall radius Rin(z,t) displayed unprecedented uniformity, varying from 95 to 130 μm over the 4.0 mm axial height captured by the radiograph.

  1. Experimental Demonstration of the Stabilizing Effect of Dielectric Coatings on Magnetically Accelerated Imploding Metallic Liners

    NASA Astrophysics Data System (ADS)

    Awe, T. J.; Peterson, K. J.; Yu, E. P.; McBride, R. D.; Sinars, D. B.; Gomez, M. R.; Jennings, C. A.; Martin, M. R.; Rosenthal, S. E.; Schroen, D. G.; Sefkow, A. B.; Slutz, S. A.; Tomlinson, K.; Vesey, R. A.

    2016-02-01

    Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70 μ m of dielectric. The dielectric tamps liner-mass redistribution from electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio [CR =Rin,0/Rin(z ,t ) ] of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. The inner-wall radius Rin(z ,t ) displayed unprecedented uniformity, varying from 95 to 130 μ m over the 4.0 mm axial height captured by the radiograph.

  2. Experimental Demonstration of the Stabilizing Effect of Dielectric Coatings on Magnetically Accelerated Imploding Metallic Liners.

    PubMed

    Awe, T J; Peterson, K J; Yu, E P; McBride, R D; Sinars, D B; Gomez, M R; Jennings, C A; Martin, M R; Rosenthal, S E; Schroen, D G; Sefkow, A B; Slutz, S A; Tomlinson, K; Vesey, R A

    2016-02-12

    Enhanced implosion stability has been experimentally demonstrated for magnetically accelerated liners that are coated with 70  μm of dielectric. The dielectric tamps liner-mass redistribution from electrothermal instabilities and also buffers coupling of the drive magnetic field to the magneto-Rayleigh-Taylor instability. A dielectric-coated and axially premagnetized beryllium liner was radiographed at a convergence ratio [CR=Rin,0/Rin(z,t)] of 20, which is the highest CR ever directly observed for a strengthless magnetically driven liner. The inner-wall radius Rin(z,t) displayed unprecedented uniformity, varying from 95 to 130  μm over the 4.0 mm axial height captured by the radiograph. PMID:26918996

  3. Exaggerating psychopathology produces residual effects that are resistant to corrective feedback: an experimental demonstration.

    PubMed

    Merckelbach, Harald; Dandachi-FitzGerald, Brechje; van Mulken, Peter; Ponds, Rudolf; Niesten, Elly

    2015-01-01

    We explored the effects of feedback on symptom reporting. Two experimental groups (n=15 each) were given a scenario with the option to exaggerate symptoms. Compared with a control condition (n=15), both groups scored significantly higher on the Structured Inventory of Malingered Symptomatology. Next, one group was confronted in a sympathetic way about their symptom validity test failure, whereas the other group was confronted in a neutral manner. Both groups subsequently completed the Brief Symptom Inventory (BSI). BSI scores of both feedback groups remained significantly higher than those of control participants. Participants who had been provided with sympathetic feedback or neutral feedback did not differ in their BSI scores. Even participants who indicated during the exit interview that they had given up symptom exaggeration attained significantly higher BSI scores than those of controls, indicating that exaggeration has residual effects that are resistant to corrective feedback. We discuss cognitive dissonance as a model for understanding the residual effects of symptom exaggeration. PMID:25529587

  4. Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation.

    PubMed

    Sutoo, Den'etsu; Akiyama, Kayo

    2004-08-01

    The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. Music might regulate and/or affect various brain functions through dopaminergic neurotransmission, and might therefore be effective for rectification of symptoms in various diseases that involve DA dysfunction. PMID:15246862

  5. Student Evaluations of Teaching: Combining the Meta-Analyses and Demonstrating Further Evidence for Effective Use

    ERIC Educational Resources Information Center

    Wright, Stephen L.; Jenkins-Guarnieri, Michael A.

    2012-01-01

    There is a plethora of research on student evaluations of teaching (SETs) regarding their validity, susceptibility to bias, practical use and effective implementation. Given that there is not one study summarising all these domains of research, a comprehensive overview of SETs was conducted by combining all prior meta-analyses related to SETs.…

  6. A Simple Experiment to Demonstrate the Effects of Cracks on Materials Strength

    ERIC Educational Resources Information Center

    Sauls, Frederick C.

    2011-01-01

    A simple in-class experiment was designed to expose students to an aspect of materials science dealing with defects. Students break a series of paper strips to gauge the breaking strength. A precut transverse "crack" weakens the paper strip by a surprising amount. Adding a precut "crack stopper" greatly reduces the effect of the original "crack".…

  7. Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations

    PubMed Central

    Patel, Chirag J.; Burford, Belinda; Ioannidis, John P.A

    2015-01-01

    Objectives Model specification -- what adjusting variables are analytically modeled –may influence results of observational associations. We present a standardized approach to quantify the variability of results obtained with choices of adjustments called the “vibration of effects” (VoE). Study Design and Setting We estimated the VoE for 417 clinical, environmental, and physiological variables in association with all-cause mortality using National Health and Nutrition Examination Survey data. We selected 13 variables as adjustment co-variates and computed 8,192 Cox models for each of 417 variables’ associations with all-cause mortality. Results We present the VoE by assessing the variance of the effect size and in the −log10(p-value) obtained by different combinations of adjustments. We present whether there are multimodality patterns in effect sizes and p-values and the trajectory of results with increasing adjustments. For 31% of the 417 variables we observed a Janus effect, with the effect being in opposite direction in the 99th versus the 1st percentile of analyses. For example, the vitamin E variant α-tocopherol had a VoE that indicated higher and lower risk for mortality. Conclusions Estimating VoE offers empirical estimates of associations are under different model specifications. When VoE is large, claims for observational associations should be very cautious. PMID:26279400

  8. Demonstrating the Effectiveness of an Integrated and Intensive Research Methods and Statistics Course Sequence

    ERIC Educational Resources Information Center

    Pliske, Rebecca M.; Caldwell, Tracy L.; Calin-Jageman, Robert J.; Taylor-Ritzler, Tina

    2015-01-01

    We developed a two-semester series of intensive (six-contact hours per week) behavioral research methods courses with an integrated statistics curriculum. Our approach includes the use of team-based learning, authentic projects, and Excel and SPSS. We assessed the effectiveness of our approach by examining our students' content area scores on the…

  9. A Peer-Assisted Learning Program and Its Effect on Student Skill Demonstration

    ERIC Educational Resources Information Center

    Carr, W. David; Volberding, Jennifer; Vardiman, Phillip

    2011-01-01

    Objective: To explore the effect of an intentional Peer-Assisted Learning (PAL) program on peer-tutors and peer-tutees for performance on specific psychomotor skills. Design and Setting: Randomized, pretest-posttest experimental design. Participants: Undergraduate students (N = 69, 42 females and 27 males, all participants were 18 to 22 years old,…

  10. A randomised trial to demonstrate the effectiveness of electronic messages on sun protection behaviours.

    PubMed

    Szabó, Csanád; Ócsai, Henriette; Csabai, Márta; Kemény, Lajos

    2015-08-01

    Message exposure is effective at changing a variety of health behaviours. Our aim was to improve sun protection habits of a volunteer sample. We conducted a randomised, non-blinded, investigator-initiated trial (from 1st June to 31st August in 2011) on the effect of an electronic text-message system on sun protection behaviours. The assessments of 149 healthy volunteer participants took place at the Clinical Department of Dermatology and Allergology at the University of Szeged in Hungary. Psychological and medical assessments were also made. Total motivation scores for adherence to sunscreen use improved at a nearly significant level (t=-1.954, p=0.054). The intervention group used sunscreens more often than the other groups according to their sun exposure diaries (F=8.173, p<0.05) and their interview results (F=3.44, p<0.05). Using electronic messages offers an effective method to improve sun protection behaviours. Our intervention is a cost-effective method and it can easily be implemented at worksites. PMID:26114220

  11. An Effective and Economical Photometer for Classroom Demonstrations and Laboratory Use

    ERIC Educational Resources Information Center

    Butterfield, Anthony E.; Young, Colin C.

    2012-01-01

    We present a simple, effective, and inexpensive spectrophotometer design that may be used in a stand-alone teaching module, and to enhance various unit operations experiments. The spectrophotometers described performed as well as a commercial option at estimating cell concentration in a bioreactor and tracking a first-order reaction. Such devices…

  12. Baca geothermal demonstration project baseline ecosystem studies of cooling tower emission effects

    SciTech Connect

    Leitner, P.; Osterling, R.; Price, D.; Westermeier, J.

    1981-03-01

    Results of baseline studies for boron, arsenic, mercury, and fluorine in vegetation and soil near the Baca Geothermal Demonstration Power Plant are provided for the 1980 sampling season. Preliminary results of visual vegetation assessments and population density studies of soil invertebrate fauna are also provided. Foliage samples were collected for chemical analysis on a total of 17 plots on 5 transects. Two to five plant species were sampled at each plot. Samples were collected in June-July and September. Soil samples were collected at each plot during September. Visual vegetation inspections were conducted along each transect. Eighty-eight soil samples were collected for soil invertebrate studies. Boron, arsenic, mercury, and fluorine levels in vegetation were within normal range for natural vegetation and crops. Concentrations of soil arsenic and mercury were comparable to foliage concentrations. Boron concentrations were lower in soil than in foliage, whereas soil fluorine concentrations were considerably higher than foliage concentrations. With the exception of heavy insect infestations in June-July, no vegetation abnormalities were noted. Preliminary soil invertebrate analysis indicated an overall arthropod density of approximately 100,000/m/sup 2/ which appears within the normal range encountered in forest and meadow soil.

  13. Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer.

    PubMed

    Liu, Xiaogang; Qiao, Qinglong; Tian, Wenming; Liu, Wenjuan; Chen, Jie; Lang, Matthew J; Xu, Zhaochao

    2016-06-01

    Replacing conventional dialkylamino substituents with a three-membered aziridine ring in naphthalimide leads to significantly enhanced brightness and photostability by effectively suppressing twisted intramolecular charge transfer formation. This replacement is generalizable in other chemical families of fluorophores, such as coumarin, phthalimide, and nitrobenzoxadiazole dyes. In highly polar fluorophores, we show that aziridinyl dyes even outperform their azetidinyl analogues in aqueous solution. We also proposed one simple mechanism that can explain the vulnerability of quantum yield to hydrogen bond interactions in protonic solvents in various fluorophore families. Such knowledge is a critical step toward developing high-performance fluorophores for advanced fluorescence imaging. PMID:27203847

  14. Data set demonstrating an absence of touch effects on social orienting in adults.

    PubMed

    Reece, Christy; Ebstein, Richard; Cheng, Xiaoqin; Ng, Tabitha; Schirmer, Annett

    2016-09-01

    Forty-five women participated in a variant of the social orienting paradigm employed in "Maternal Touch Predicts Attentional Bias Towards Faces in Young Children" (Reece, in press) [1]. On a given trial, they saw a mathematical equation and indicated whether this equation was true or false. Equations were superimposed on face or house distractors. A female experimenter sat next to the participant. In separate blocks, she either rested her hand on the participants arm or refrained from touching. Performance was poorer on trials with face than house distractors. However, experimenter touch failed to modulate this effect. Here we present raw and analyzed data of this companion experiment. PMID:27508241

  15. [DEMONSTRATION OF LIKELIHOOD OF THE NEGATIVE EFFECT OF PHYSICAL PROTECTION DURING TOTAL PROTON IRRADIATION OF MICE].

    PubMed

    Ivanov, A A; Bulynina, T M; Molokanov, A G; Vorozhtsova, S V; Utina, D M; Severyukhin, Yu S; Ushakov, I B

    2015-01-01

    The experiments were performed with outbred CD-1 male mice (SPF category). Total irradiation at 1.0; 2.5 and 5.0 Gy by protons with the average energy of 170 MeV was conducted in a level medical beam of the phasotron at the Joint Institute of Nuclear Investigations. Targets were 2 points of in-depth dose distribution, i.e. beam entrance of the object, and modified Bragg peak. As a physical protector, the comb filter increases linear energy transfer (LET) of 170 MeV entrance protons from 0.49 keV/μm to 1.6 keV/μm and, according to the bone marrow test, doubles the biological effectiveness of protons when comparing radiation doses that cause 37% inhibition of blood cell formation in the bone marrow. Physical protection increases dose rate from 0.37 Gy/min for entrance protons to 0.8 Gy/min for moderated protons which more than in thrice reduces time of irradiation needed to reach an equal radiobiological effect. PMID:26554131

  16. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1983-01-01

    Describes a lecture demonstration of a solid state phase transition using a thermodynamic material which changes state at room temperature. Also describes a demonstration on kinetics using a "Big Bang" (trade mark) calcium carbide cannon. Indicates that the cannon is safe to use. (JN)

  17. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1983-01-01

    Provides directions for setup and performance of two demonstrations. The first demonstrates the principles of Raoult's Law; using a simple apparatus designed to measure vapor pressure. The second illustrates the energy available from alcohol combustion (includes safety precautions) using an alcohol-fueled missile. (JM)

  18. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1979-01-01

    Presents two demonstrations for classroom use related to precipitation of ferrous hydroxide and to variation of vapor pressure with temperature. The former demonstration is simple and useful when discussing solubility of ionic compounds electrode potential of transition elements, and mixed valence compounds. (Author/SA)

  19. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1989-01-01

    Presented are two chemistry demonstrations: (1) an alternative method for the demonstration of the properties of alkali metals, water is added to small amounts of metal; (2) an exploration of the properties of hydrogen, helium, propane, and carbon dioxide using an open trough and candle. (MVL)

  20. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1986-01-01

    Outlines a simple, inexpensive way of demonstrating electroplating using the reaction between nickel ions and copper metal. Explains how to conduct a demonstration of the electrolysis of water by using a colored Na2SO4 solution as the electrolyte so that students can observe the pH changes. (TW)

  1. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1983-01-01

    Free radical chlorination of methane is used in organic chemistry to introduce free radical/chain reactions. In spite of its common occurrence, demonstrations of the reaction are uncommon. Therefore, such a demonstration is provided, including background information, preparation of reactants/reaction vessel, introduction of reactants, irradiation,…

  2. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1986-01-01

    Describes two demonstrations designed to help chemistry students visualize certain chemical properties. One experiment uses balloons to illustrate the behavior of gases under varying temperatures and pressures. The other uses a makeshift pea shooter and a commercial model to demonstrate atomic structure and the behavior of high-speed particles.…

  3. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1980-01-01

    Two demonstrations are described: (1) a variant of preparing purple benzene by phase transfer catalysis with quaternary ammonium salts and potassium permanganate in which crown ethers are used; (2) a corridor or "hallway" demonstration in which unknown molecular models are displayed and prizes awarded to students correctly identifying the…

  4. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1982-01-01

    Three chemistry demonstrations are described: (1) modification of copper catalysis demonstration apparatus; (2) experiments in gas-liquid chromatography with simple gas chromatography at room temperature; and (3) equilibria in silver arsenate-arsenic acid and silver phosphate-phosphoric acid systems. Procedures and materials needed are provided.…

  5. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1980-01-01

    Described is a demonstration utilized to measure the heat of vaporization using the Clausius-Clapeyron equation. Explained is that when measurement is made as part of a demonstration, it raises student's consciousness that chemistry is experimentally based. (Author/DS)

  6. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Describes two laboratory demonstrations in chemistry. One uses dry ice, freon, and freezer bags to demonstrate volume changes, vapor-liquid equilibrium, a simulation of a rain forest, and vaporization. The other uses the clock reaction technique to illustrate fast reactions and kinetic problems in releasing carbon dioxide during respiration. (TW)

  7. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1990-01-01

    Presented are three demonstrations: "The Construction and Use of Commercial Voltaic Cell Displays in Freshman Chemistry"; Dramatizing Isotopes: Deuterated Ice Cubes Sink"; and "A Simple Apparatus to Demonstrate Differing Gas Diffusion Rates (Graham's Law)." Materials, procedures, and safety considerations are discussed. (CW)

  8. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Background information and procedures are provided for a second part to the dichromate volcano demonstration. The green ash produced during the demonstration is reduced to metal using aluminothermy (Goldschmide process). Also describes suitable light sources and spectroscopes for student observation of emission spectra in lecture halls. (JN)

  9. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1986-01-01

    Provides three descriptions of demonstrations used in various chemistry courses. Includes the use of a simple demonstration model to illustrate principles of chromatography, techniques for using balloons to teach about the behavior of gases, and the use of small concentrations of synthetic polyelectrolytes to induce the flocculation hydrophobic…

  10. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1983-01-01

    Discusses a supplement to the "water to rose" demonstration in which a pink color is produced. Also discusses blood buffer demonstrations, including hydrolysis of sodium bicarbonate, simulated blood buffer, metabolic acidosis, natural compensation of metabolic acidosis, metabolic alkalosis, acidosis treatment, and alkalosis treatment. Procedures…

  11. Experimental evidence needed to demonstrate inter- and trans-generational effects of ancestral experiences in mammals

    PubMed Central

    Dias, Brian G.; Ressler, Kerry J.

    2015-01-01

    Environmental factors routinely influence an organism’s biology. The inheritance or transmission of such influences to descendant generations would be an efficient mode of information transfer across generations. The developmental stage at which a specific environment is encountered by the ancestral generation, and the number of generations over which information about that environment is registered, determines an inter- vs. trans-generational effect of ancestral influence. This commentary will outline the distinction between these influences. While seductive in principle, inter- and trans-generational inheritance in mammals is a hotly debated area of research inquiry. We present constructive criticism of such inheritance, and suggest potential experimental avenues for reconciliation. Finally, epigenetic mechanisms present an avenue for gene regulation that is dynamic. We briefly discuss how such malleability affords the potential for a reversal of any detrimental environmental influences that might have adversely impacted ancestral or descendant generations. PMID:25154497

  12. A FIELD DEMONSTRATION OF THE EFFECTIVENESS AND FEASIBILITY OF EARLY ADMISSION TO SCHOOL FOR MENTALLY ADVANCED CHILDREN.

    ERIC Educational Resources Information Center

    BIRCH, JACK W.; AND OTHERS

    A 4-YEAR STUDY DEMONSTRATED THE FEASIBILITY AND EFFECTIVENESS OF EARLY ADMISSION TO SCHOOL FOR MENTALLY ADVANCED CHILDREN. APPROXIMATELY 800 CHILDREN WERE SCREENED TO LOCATE THE 36 CHILDREN WHO ENTERED KINDERGARTEN BEFORE THE USUAL TIME. CRITERIA FOR EARLY ADMISSION INCLUDED AN INTELLIGENCE QUOTIENT APPROXIMATELY 130 OR HIGHER, SOCIAL MATURITY AT…

  13. Effectiveness of Demonstrations Supported by ICT Tools on Upper Secondary School Students' Attitudes towards the Learning of Physics

    ERIC Educational Resources Information Center

    Yap, Boon Chien; Chew, Charles

    2014-01-01

    This quantitative research study reports the effectiveness of demonstrations supported by appropriate information and communication technology (ICT) tools such as dataloggers, animations and video clips on upper secondary school students' attitudes towards the learning of physics. A sample of 94 secondary four express stream (age 16 years)…

  14. 30 CFR 243.12 - May I substitute a demonstration of financial solvency for a bond posted before the effective...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I substitute a demonstration of financial solvency for a bond posted before the effective date of this rule? 243.12 Section 243.12 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS...

  15. The Effectiveness of Online Instructional Videos in the Acquisition and Demonstration of Cognitive, Affective and Psychomotor Rehabilitation Skills

    ERIC Educational Resources Information Center

    Cooper, Darren; Higgins, Steve

    2015-01-01

    The use of instructional videos to teach clinical skills is an ever growing area of e-learning based upon observational learning that is cited as one of the most basic yet powerful learning strategies. The aim of the current study is to evaluate the effectiveness of online instructional videos for the acquisition and demonstration of cognitive,…

  16. The Effect of Interactive Lecture Demonstrations on Students' Understanding of Heat and Temperature: A Study from Thailand

    ERIC Educational Resources Information Center

    Tanahoung, Choksin; Chitaree, Ratchapak; Soankwan, Chernchok; Sharma, Manjula D.; Johnston, Ian D.

    2009-01-01

    The purpose of this study was to investigate the effectiveness of Interactive Lecture Demonstrations over traditional instruction on university students' understanding of heat and temperature. The participants were 327 first year undergraduate students from two science classes in two academic years from the same university in Thailand. One class…

  17. The environmental virtual observatory pilot (EVOp): a cloud solution demonstrating effective science for efficient decisions

    NASA Astrophysics Data System (ADS)

    Gurney, R. J.; Emmett, B.; McDonald, A.

    2012-12-01

    Environmental managers and policy makers face a challenging future trying to accommodate growing expectations of environmental well-being, while subject to maturing regulation, constrained budgets and a public scrutiny that expects easier and more meaningful access to data and decision logic. To support such a challenge requires new tools and new approaches. The EVOp is an initiative from the UK Natural Environment Research Council (NERC) designed to deliver proof of concept for these new tools and approaches. A series of exemplar 'big catchment science questions' are posed and the prospects for their solution are assessed. These are then used to develop cloud solutions for serving data, models, visualisation and analysis tools to scientists, regulators, private companies and the public, all of whom have different expectations of what environmental information is important. Approaches are tested regularly with users using SCRUM. The VO vision encompasses seven key ambitions: i. being driven by the need to contribute to the solution of major environmental issues that impinge on, or link to, catchment science ii. having the flexibility and adaptability to address future problems not yet defined or fully clarified iii. being able to communicate issues and solutions to a range of audiences iv. supporting easy access by a variety of users v. drawing meaningful information from data and models and identifying the constraints on application in terms of errors, uncertainties, etc vi. adding value and cost effectiveness to current investigations by supporting transfer and scale adjustment thus limiting the repetition of expensive field monitoring addressing essentially the same issues in varying locations vii. promoting effective interfacing of robust science with a variety of end users by using terminology or measures familiar to the user (or required by regulation), including financial and carbon accounting, whole life or fixed period costing, risk as probability or as

  18. Experimental Demonstration of Microwave Signal/Electric Thruster Plasma Interaction Effects

    NASA Technical Reports Server (NTRS)

    Zaman, Afroz J.; Lambert, Kevin M.; Curran, Frank M.

    1995-01-01

    An experiment was designed and conducted in the Electric Propulsion Laboratory of NASA Lewis Research Center to assess the impact of ion thruster exhaust plasma plume on electromagnetic signal propagation. A microwave transmission experiment was set up inside the propulsion test bed using a pair of broadband horn antennas and a 30 cm 2.3 kW ion thruster. Frequency of signal propagation covered from 6.5 to 18 GHz range. The stainless steel test bed when enclosed can be depressurized to simulate a near vacuum environment. A pulsed CW system with gating hardware was utilized to eliminate multiple chamber reflections from the test signal. Microwave signal was transmitted and received between the two hours when the thruster was operating at a given power level in such a way that the signal propagation path crossed directly through the plume volume. Signal attenuation and phase shift due to the plume was measured for the entire frequency band. Results for this worst case configuration simulation indicate that the effects of the ion thruster plume on microwave signals is a negligible attenuation (within 0.15 dB) and a small phase shift (within 8 deg.). This paper describes the detailed experiment and presents some of the results.

  19. Solubility of Au in Intermediate Silicate Melts : Experimental Demonstration of the Effect of S

    NASA Astrophysics Data System (ADS)

    Jego, S.; Pichavant, M.; Mavrogenes, J.

    2006-05-01

    .5 being the dissolved gold species. Gold solubility in S-bearing charges appears much higher, ranging from 250 to 5200 ppb. Gold content is higher in reduced (1000 to 5200 ppb) than in more oxidized conditions (250 to 2500 ppb), and is not affected by melt composition. At each fO2, the gold content of silicate melt appears to be the result of a complex competition between fO2 and fS2. Under very oxidized conditions, these two parameters seem to exactly counterbalance their effects, leading to a roughly constant gold content (500 to 660 ppb). On the contrary, under more reduced conditions, the effect of fS2 appears the strongest, leading to a direct dependence of gold solubility on sulfur content. The dissolved gold complexes consistent with the data may be Au3S4+ at NNO+1.5 and Au3S5- at NNO-1. This study shows conclusively that Au transport and concentration in silicic melts is dramatically enhanced by the presence of sulfur. A major consequence is that sulfide crystallization does not scavenge all Au present in the magma, but allows gold-enriched residual magmas, especially those that are moderately reduced (NNO-1 to NNO+1.5), to be emplaced in the upper crust. Gold enrichment in porphyry- and epithermal-type deposits can be directly linked with sulfur incorporation and abundances in magmas.

  20. Field Effect Transistor Behavior in Electrospun Polyaniline/Polyethylene Oxide Demonstrated

    NASA Technical Reports Server (NTRS)

    Mueller, Carl H.; Theofylaktos, Onoufrios; Robinson, Daryl C.; Miranda, Felix A.

    2004-01-01

    Novel transistors and logic devices based on nanotechnology concepts are under intense development. The potential for ultra-low-power circuitry makes nanotechnology attractive for applications such as digital electronics and sensors. For NASA applications, nanotechnology offers tremendous opportunities for increased onboard data processing, and thus autonomous decisionmaking ability, and novel sensors that detect and respond to environmental stimuli with little oversight requirements. Polyaniline/polyethylene oxide (PANi/PEO) nanofibers are of interest because they have electrical conductivities that can be changed from insulating to metallic by varying the doping levels and conformations of the polymer chain. At the NASA Glenn Research Center, we have observed field effect transistor (FET) behavior in electrospun PANi/PEO nanofibers doped with camphorsulfonic acid. The nanofibers were deposited onto Au electrodes, which had been prepatterned onto oxidized silicon substrates. The preceding scanning electron image shows the device used in the transistor measurements. Saturation channel currents are observed at surprisingly low source/drain voltages (see the following graph). The hole mobility in the depletion regime is 1.4x10(exp -4)sq cm/V sec, whereas the one-dimensional charge density (at zero gate bias) is calculated to be approximately 1 hole per 50 two-ring repeat units of polyaniline, consistent with the rather high channel conductivity (approx.10(exp -3) S/cm). Reducing or eliminating the PEO content in the fiber is expected to enhance device parameters. Electrospinning is thus proposed as a simple method of fabricating one-dimensional polymer FET's.

  1. An in silico model to demonstrate the effects of Maspin on cancer cell dynamics.

    PubMed

    Al-Mamun, M A; Farid, D M; Ravenhil, L; Hossain, M A; Fall, C; Bass, R

    2016-01-01

    Most cancer treatments efficacy depends on tumor metastasis suppression, where tumor suppressor genes play an important role. Maspin (Mammary Serine Protease Inhibitor), an non-inhibitory serpin has been reported as a potential tumor suppressor to influence cell migration, adhesion, proliferation and apoptosis in in vitro and in vivo experiments in last two decades. Lack of computational investigations hinders its ability to go through clinical trials. Previously, we reported first computational model for maspin effects on tumor growth using artificial neural network and cellular automata paradigm with in vitro data support. This paper extends the previous in silico model by encompassing how maspin influences cell migration and the cell-extracellular matrix interaction in subcellular level. A feedforward neural network was used to define each cell behavior (proliferation, quiescence, apoptosis) which followed a cell-cycle algorithm to show the microenvironment impacts over tumor growth. Furthermore, the model concentrates how the in silico experiments results can further confirm the fact that maspin reduces cell migration using specific in vitro data verification method. The data collected from in vitro and in silico experiments formulates an unsupervised learning problem which can be solved by using different clustering algorithms. A density based clustering technique was developed to measure the similarity between two datasets based on the number of links between instances. Our proposed clustering algorithm first finds the nearest neighbors of each instance, and then redefines the similarity between pairs of instances in terms of how many nearest neighbors share the two instances. The number of links between two instances is defined as the number of common neighbors they have. The results showed significant resemblances with in vitro experimental data. The results also offer a new insight into the dynamics of maspin and establish as a metastasis suppressor gene

  2. Polarized Light Corridor Demonstrations.

    ERIC Educational Resources Information Center

    Davies, G. R.

    1990-01-01

    Eleven demonstrations of light polarization are presented. Each includes a brief description of the apparatus and the effect demonstrated. Illustrated are strain patterns, reflection, scattering, the Faraday Effect, interference, double refraction, the polarizing microscope, and optical activity. (CW)

  3. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1980-01-01

    Presented is a Corridor Demonstration which can be set up in readily accessible areas such as hallways or lobbies. Equipment is listed for a display of three cells (solar cells, fuel cells, and storage cells) which develop electrical energy. (CS)

  4. Kinetic Demonstration.

    ERIC Educational Resources Information Center

    Burgardt, Erik D.; Ryan, Hank

    1996-01-01

    Presents a unit on chemical reaction kinetics that consists of a predemonstration activity, the demonstration, and a set of postdemonstration activities that help students transfer the concepts to actual chemical reactions. Simulates various aspects of chemical reaction kinetics. (JRH)

  5. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Roffia, Sergio; And Others

    1988-01-01

    Reports two electrochemical demonstrations. Uses a hydrogen-oxygen fuel cell to power a clock. Includes description of methods and materials. Investigates the "potato clock" used with different fruits. Lists emf and current for various fruit and electrode combinations. (ML)

  6. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Rehfeld, D. W.; And Others

    1988-01-01

    Describes two demonstrations (1) a dust explosion using a coffee can, candle, rubber tubing, and cornstarch and (2) forming a silicate-polyvinyl alcohol polymer which can be pressed into plastic sheets or molded. Gives specific instructions. (MVL)

  7. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Presents three demonstrations suitable for undergraduate chemistry classes. Focuses on experiments with calcium carbide, the induction by iron of the oxidation of iodide by dichromate, and the classical iodine clock reaction. (ML)

  8. Tested Demonstrations

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1977-01-01

    Describes a room-temperature method for demonstrating phosphorescence by including samples in a polymer matrix. Also discusses the Old Nassau Reaction, a clock reaction which turns orange then black. (MLH)

  9. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L.

    1990-01-01

    Included are three demonstrations that include the phase change of ice when under pressure, viscoelasticity and colloid systems, and flame tests for metal ions. The materials, procedures, probable results, and applications to real life situations are included. (KR)

  10. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1986-01-01

    Background information, list of materials needed, and procedures used are provided for a demonstration involving the transformation of a hydrophobic liquid to a partially hydrophobic semisolid. Safety considerations are noted. (JN)

  11. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1988-01-01

    Describes two demonstrations for use in college chemistry classes. Includes "Spectroscopy in Large Lecture Halls" and "The Endothermic Dissolution of Ammonium Nitrate." Gives materials lists and procedures as well as a discussion of the results. (CW)

  12. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1979-01-01

    Presents a recipe for the Nylon Rope Trick, which is considered to be one of the most spectacular demonstrations in chemistry. Materials for growing the polymer and some safety precautions are given. (SA)

  13. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1989-01-01

    Discusses three broad classes of magnetic behavior: diamagnetic, paramagnetic, and ferromagnetic. Presents a simple lecture demonstration using an overhead projector to synthesize triiron tetraoxide and to show its interaction with a magnetic field and comparing it to a paramagnetic material. (MVL)

  14. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1985-01-01

    Describes two demonstrations that require almost no preparation time, are visually stimulating, and present a variety of material for class discussion (with sample questions provided). The first involves a sodium bicarbonate hydrochloric acid volcano; the second involves a dissolving polystyrene cup. Procedures used and information on…

  15. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1981-01-01

    Provides instructions and a list of materials needed to demonstrate: (1) a model of the quantum mechanical atom; (2) principles involved in metal corrosion and in the prevention of this destructive process by electrochemical means; and (3) a Thermit reaction, modified to make it more dramatic and interesting for students. (SK)

  16. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1985-01-01

    Background information, procedures, and typical results obtained are provided for two demonstrations. The first involves the colorful complexes of copper(II). The second involves reverse-phase separation of Food, Drug, and Cosmetic (FD & C) dyes using a solvent gradient. (JN)

  17. Tested Demonstrations.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1987-01-01

    Describes two demonstrations to illustrate characteristics of substances. Outlines a method to detect the changes in pH levels during the electrolysis of water. Uses water pistols, one filled with methane gas and the other filled with water, to illustrate the differences in these two substances. (TW)

  18. Tested Demonstrations

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1976-01-01

    Describes two demonstrations: one that illustrates the attainment of equilibrium in first-order reactions by changing the volumes of two beakers of water at a specified rate, and another that illustrates the role of indicators in showing pH changes in buffer solutions. (MLH)

  19. Glucosamine Supplementation Demonstrates a Negative Effect On Intervertebral Disc Matrix in an Animal Model of Disc Degeneration

    PubMed Central

    Jacobs, Lloydine; Vo, Nam; Coehlo, J. Paulo; Dong, Qing; Bechara, Bernard; Woods, Barrett; Hempen, Eric; Hartman, Robert; Preuss, Harry; Balk, Judith; Kang, James; Sowa, Gwendolyn

    2013-01-01

    Study Design Laboratory based controlled in vivo study Objective To determine the in vivo effects of oral glucosamine sulfate on intervertebral disc degeneration Summary of Background Data Although glucosamine has demonstrated beneficial effect in articular cartilage, clinical benefit is uncertain. A CDC report from 2009 reported that many patients are using glucosamine supplementation for low back pain (LBP), without significant evidence to support its use. Because disc degeneration is a major contributor of LBP, we explored the effects of glucosamine on disc matrix homeostasis in an animal model of disc degeneration. Methods Eighteen skeletally mature New Zealand White rabbits were divided into four groups: control, annular puncture, glucosamine, and annular puncture+glucosamine. Glucosamine treated rabbits received daily oral supplementation with 107mg/day (weight based equivalent to human 1500mg/day). Annular puncture surgery involved puncturing the annulus fibrosus (AF) of 3 lumbar discs with a 16G needle to induce degeneration. Serial MRIs were obtained at 0, 4, 8, 12, and 20 weeks. Discs were harvested at 20 weeks for determination of glycosaminoglycan(GAG) content, relative gene expression measured by RT-PCR, and histological analyses. Results The MRI index and NP area of injured discs of glucosamine treated animals with annular puncture was found to be lower than that of degenerated discs from rabbits not supplemented with glucosamine. Consistent with this, decreased glycosaminoglycan was demonstrated in glucosamine fed animals, as determined by both histological and GAG content. Gene expression was consistent with a detrimental effect on matrix. Conclusions These data demonstrate that the net effect on matrix in an animal model in vivo, as measured by gene expression, MRI, histology, and total proteoglycan is anti-anabolic. This raises concern over this commonly used supplement, and future research is needed to establish the clinical relevance of these

  20. A Demonstration Project in New York and Virginia: Retrofitting Cost-Effective Roll-over Protective Structures (CROPS) on Tractors

    PubMed Central

    Hard, David L.; McKenzie, E. A.; Cantis, Douglas; May, John; Sorensen, Julie; Bayes, Barbara; Madden, Erin; Wyckoff, Sherry; Stone, Bruce; Maass, Jimmy

    2015-01-01

    The NIOSH cost-effective roll-over protective structure (CROPS) demonstration project sought to determine whether three prototype roll-over protective structures (ROPS) designed to be retrofitted on Ford 8N, Ford 3000, Ford 4000, and Massey Ferguson 135 tractors could be installed in the field and whether they would be acceptable by the intended end users (farmers). There were a total of 50 CROPS demonstrators (25 in New York and 25 in Virginia), with 45 observers attending the New York CROPS demonstrations and 36 observers attending the Virginia CROPS demonstrations, for a total of 70 participants in New York and 61 in Virginia. The oldest retrofitted tractors were 77 to 62 years old, while the newest retrofitted tractors were 40 to 37 years old. The most frequently retrofitted tractor in the CROPS demonstration project was a Ford 3000 series tractor (n = 19; 38%), followed by Ford 4000 (n = 11; 22%), Massey Ferguson 135 (n = 11; 22%), and Ford 8N (n = 9; 18%). A major issue of CROPS retrofitting was the rear wheel fenders. The effort involved in disassembling the fenders (removing the old bolts was often faster by cutting them with a torch), modifying the fender mounting brackets, and then reinstalling the fenders with the CROPS generally required the most time. In addition, various other semi-permanent equipment attachments, such as front-end loaders, required additional time and effort to fit with the CROPS. Demonstrators were asked to rank the reasons why they had not retrofitted their tractors with ROPS until they had enrolled in the CROPS demonstration program. ROPS “cost too much” was ranked as the primary reason for participants in both states (80% for New York and 88% for Virginia). The second highest ranked reasons were “ROPS wasn’t available” for Virginia (80%) and “hassle to find ROPS” for New York (69%). The third highest ranked reasons were “not enough time to find ROPS” for New York (67%) and “hassle to find ROPS” for Virginia

  1. A Demonstration Project in New York and Virginia: Retrofitting Cost-Effective Roll-over Protective Structures (CROPS) on Tractors.

    PubMed

    Hard, D L; McKenzie, E A; Cantis, D; May, J; Sorensen, J; Bayes, B; Madden, E; Wyckoff, S; Stone, B; Maass, J

    2015-07-01

    The NIOSH cost-effective roll-over protective structure (CROPS) demonstration project sought to determine whether three prototype roll-over protective structures (ROPS) designed to be retrofitted on Ford 8N, Ford 3000, Ford 4000, and Massey Ferguson 135 tractors could be installed in the field and whether they would be acceptable by the intended end users (farmers). There were a total of 50 CROPS. demonstrators (25 in New York and 25 in Virginia), with 45 observers attending the New York CROPS demonstrations and 36 observers attending the Virginia CROPS demonstrations, for a total of 70 participants in New York and 61 in Virginia. The oldest retrofitted tractors were 77 to 62 years old, while the newest retrofitted tractors were 40 to 37 years old. The most frequently retrofitted tractor in the CROPS demonstration project was a Ford 3000 series tractor (n = 19; 38%), followed by Ford 4000 (n = 11; 22%), Massey Ferguson 135 (n = 11; 22%), and Ford 8N (n = 9; 18%). A major issue of CROPS retrofitting was the rear wheel fenders. The effort involved in disassembling the fenders (removing the old bolts was often faster by cutting them with a torch), modifying the fender mounting brackets, and then reinstalling the fenders with the CROPS generally required the most time. In addition, various other semi-permanent equipment attachments, such as front-end loaders, required additional time and effort to fit with the CROPS. Demonstrators were asked to rank the reasons why they had not retrofitted their tractors with ROPS until they had enrolled in the CROPS demonstration program. ROPS "cost too much" was ranked as the primary reason for participants in both states (80% for New York and 88% for Virginia). The second highest ranked reasons were "ROPS wasn't available" for Virginia (80%) and "hassle to find ROPS" for New York (69%). The third highest ranked reasons were "not enough time to find ROPS" for New York (67%) and "hassle to find ROPS" for Virginia (79%). All

  2. Computational fluid dynamics: a suitable assessment tool for demonstrating the antiobstructive effect of drugs in the therapy of allergic rhinitis.

    PubMed

    Achilles, N; Pasch, N; Lintermann, A; Schröder, W; Mösges, R

    2013-02-01

    This systematic review aims first to summarize the previous areas of application of computational fluid dynamics (CFD) and then to demonstrate that CFD is also a suitable instrument for generating three-dimensional images that depict drug effects on nasal mucosa. Special emphasis is placed on the three-dimensional visualization of the antiobstructive effect of nasal steroids and antihistamines in the treatment of allergic rhinitis. In the beginning, CFD technology was only used to demonstrate physiological and pathophysiological airflow conditions in the nose and to aid in preoperative planning and postoperative monitoring of surgical outcome in the field of rhinosurgery. The first studies using CFD examined nasal respiratory physiology, important functions of the nose, such as conditioning and warming of inspired air, and the influence of pathophysiological changes on nasal breathing. Also, postoperative outcome of surgical procedures could be "predicted" using the nasal airflow model. Later studies focused on the three-dimensional visualization of the effect of nasal sprays in healthy subjects and postoperative patients. A completely new approach, however, was the use of CFD in the area of allergic rhinitis and the treatment of its cardinal symptom of nasal obstruction. In two clinical trials, a suitable patient with a positive history of allergic rhinitis was enrolled during a symptom-free period after the pollen season. The patient developed typical allergic rhinitis symptoms after provocation with birch pollen. The 3-D visualization showed that the antiallergic treatment successfully counteracted the effects of nasal allergen provocation on nasal airflow. These observations were attributed to the antiobstructive effect of a nasal steroid (mometasone furoate) and a systemic antihistamine (levocetirizine), respectively. CFD therefore constitutes a non-invasive, precise, reliable and objective examination procedure for generating three-dimensional images that

  3. Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.

    PubMed

    Marshall, Pamela A; Jurutka, Peter W; Wagner, Carl E; van der Vaart, Arjan; Kaneko, Ichiro; Chavez, Pedro I; Ma, Ning; Bhogal, Jaskaran S; Shahani, Pritika; Swierski, Johnathon C; MacNeill, Mairi

    2015-03-01

    In order to determine the feasibility of utilizing novel rexinoids for chemotherapeutics and as potential treatments for neurological conditions, we undertook an assessment of the side effect profile of select rexinoid X receptor (RXR) analogs that we reported previously. We assessed pharmacokinetic profiles, lipid and thyroid-stimulating hormone (TSH) levels in rats, and cell culture activity of rexinoids in sterol regulatory element-binding protein (SREBP) induction and thyroid hormone inhibition assays. We also performed RNA sequencing of the brain tissues of rats that had been dosed with the compounds. We show here for the first time that potent rexinoid activity can be uncoupled from drastic lipid changes and thyroid axis variations, and we propose that rexinoids can be developed with improved side effect profiles than the parent compound, bexarotene (1). PMID:26038698

  4. Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles

    PubMed Central

    Marshall, Pamela A; Jurutka, Peter W; Wagner, Carl E; van der Vaart, Arjan; Kaneko, Ichiro; Chavez, Pedro I; Ma, Ning; Bhogal, Jaskaran S; Shahani, Pritika; Swierski, Johnathon C; MacNeill, Mairi

    2015-01-01

    In order to determine the feasibility of utilizing novel rexinoids for chemotherapeutics and as potential treatments for neurological conditions, we undertook an assessment of the side effect profile of select rexinoid X receptor (RXR) analogs that we reported previously. We assessed pharmacokinetic profiles, lipid and thyroid-stimulating hormone (TSH) levels in rats, and cell culture activity of rexinoids in sterol regulatory element-binding protein (SREBP) induction and thyroid hormone inhibition assays. We also performed RNA sequencing of the brain tissues of rats that had been dosed with the compounds. We show here for the first time that potent rexinoid activity can be uncoupled from drastic lipid changes and thyroid axis variations, and we propose that rexinoids can be developed with improved side effect profiles than the parent compound, bexarotene (1). PMID:26038698

  5. Statistical demonstration of the relative effect of surface chemistry and roughness on human osteoblast short-term adhesion.

    PubMed

    Anselme, K; Bigerelle, M

    2006-05-01

    The effects of material composition, surface chemistry or surface topography on cell attachment (short-term adhesion) have been largely studied on bone-derived cells. However, no statistical demonstration of these effects has been performed until now. With this objective, we quantified the attachment after 24 hours of human osteoblasts on pure titanium, titanium alloy and stainless steel substrates presenting 6 different surface morphologies and 2 different roughness amplitude obtained by sand-blasting, electro-erosion, acid etching, polishing and machine-tooling. The coating by a gold-palladium layer of these surfaces allowed determining the relative effect of the surface roughness and of the surface chemistry. By multiple analysis of variance, we demonstrated that neither material composition nor surface roughness amplitude influenced cell attachment except on sandblasted pure titanium substrates. On the contrary, a high significant influence of the process used to produce the surface was observed meaning that the main influent factor on cell attachment could be either the surface morphology or the surface chemistry induced by the process. As the coating of surfaces by a gold-palladium layer decreased significantly the attachment of cells on the majority of substrates, we concluded that attachment is rather influenced by surface chemistry than by surface topography. PMID:16688588

  6. Role of DNA Protection and Repair in Resistance of Bacillus subtilis Spores to Ultrahigh Shock Pressures Simulating Hypervelocity Impacts▿

    PubMed Central

    Moeller, Ralf; Horneck, Gerda; Rabbow, Elke; Reitz, Günther; Meyer, Cornelia; Hornemann, Ulrich; Stöffler, Dieter

    2008-01-01

    Impact-induced ejections of rocks from planetary surfaces are frequent events in the early history of the terrestrial planets and have been considered as a possible first step in the potential interplanetary transfer of microorganisms. Spores of Bacillus subtilis were used as a model system to study the effects of a simulated impact-caused ejection on rock-colonizing microorganisms using a high-explosive plane wave setup. Embedded in different types of rock material, spores were subjected to extremely high shock pressures (5 to 50 GPa) lasting for fractions of microseconds to seconds. Nearly exponential pressure response curves were obtained for spore survival and linear dependency for the induction of sporulation-defective mutants. Spores of strains defective in major small, acid-soluble spore proteins (SASP) (α/β-type SASP) that largely protect the spore DNA and spores of strains deficient in nonhomologous-end-joining DNA repair were significantly more sensitive to the applied shock pressure than were wild-type spores. These results indicate that DNA may be the sensitive target of spores exposed to ultrahigh shock pressures. To assess the nature of the critical physical parameter responsible for spore inactivation by ultrahigh shock pressures, the resulting peak temperature was varied by lowering the preshock temperature, changing the rock composition and porosity, or increasing the water content of the samples. Increased peak temperatures led to increased spore inactivation and reduced mutation rates. The data suggested that besides the potential mechanical stress exerted by the shock pressure, the accompanying high peak temperatures were a critical stress parameter that spores had to cope with. PMID:18791028

  7. GASIS demonstration

    SciTech Connect

    Vidas, E.H.

    1995-04-01

    A prototype of the GASIS database and retrieval software has been developed and is the subject of this poster session and computer demonstration. The prototype consists of test or preliminary versions of the GASIS Reservoir Data System and Source Directory datasets and the software for query and retrieval. The prototype reservoir database covers the Rocky Mountain region and contains the full GASIS data matrix (all GASIS data elements) that will eventually be included on the CD-ROM. It is populated for development purposes primarily by the information included in the Rocky Mountain Gas Atlas. The software has been developed specifically for GASIS using Foxpro for Windows. The application is an executable file that does not require Foxpro to run. The reservoir database software includes query and retrieval, screen display, report generation, and data export functions. Basic queries by state, basin, or field name will be assisted by scrolling selection lists. A detailed query screen will allow record selection on the basis of any data field, such as depth, cumulative production, or geological age. Logical operators can be applied to any-numeric data element or combination of elements. Screen display includes a {open_quotes}browse{close_quotes} display with one record per row and a detailed single record display. Datasets can be exported in standard formats for manipulation with other software packages. The Source Directory software will allow record retrieval by database type or subject area.

  8. Demonstrating Bacterial Flagella.

    ERIC Educational Resources Information Center

    Porter, John R.; And Others

    1992-01-01

    Describes an effective laboratory method for demonstrating bacterial flagella that utilizes the Proteus mirabilis organism and a special harvesting technique. Includes safety considerations for the laboratory exercise. (MDH)

  9. A Boyle's Law Demonstrator.

    ERIC Educational Resources Information Center

    Sathe, Dileep V.

    1984-01-01

    The usual apparatus for demonstrating Boyle's law produces reasonably accurate results, but is not impressive as a demonstration because students cannot easily appreciate the change in pressure. An apparatus designed to produce a more effective demonstration is described. Procedures employed are also described. (JN)

  10. A novel approach to delayed-start analyses for demonstrating disease-modifying effects in Alzheimer's disease.

    PubMed

    Liu-Seifert, Hong; Andersen, Scott W; Lipkovich, Ilya; Holdridge, Karen C; Siemers, Eric

    2015-01-01

    One method for demonstrating disease modification is a delayed-start design, consisting of a placebo-controlled period followed by a delayed-start period wherein all patients receive active treatment. To address methodological issues in previous delayed-start approaches, we propose a new method that is robust across conditions of drug effect, discontinuation rates, and missing data mechanisms. We propose a modeling approach and test procedure to test the hypothesis of noninferiority, comparing the treatment difference at the end of the delayed-start period with that at the end of the placebo-controlled period. We conducted simulations to identify the optimal noninferiority testing procedure to ensure the method was robust across scenarios and assumptions, and to evaluate the appropriate modeling approach for analyzing the delayed-start period. We then applied this methodology to Phase 3 solanezumab clinical trial data for mild Alzheimer's disease patients. Simulation results showed a testing procedure using a proportional noninferiority margin was robust for detecting disease-modifying effects; conditions of high and moderate discontinuations; and with various missing data mechanisms. Using all data from all randomized patients in a single model over both the placebo-controlled and delayed-start study periods demonstrated good statistical performance. In analysis of solanezumab data using this methodology, the noninferiority criterion was met, indicating the treatment difference at the end of the placebo-controlled studies was preserved at the end of the delayed-start period within a pre-defined margin. The proposed noninferiority method for delayed-start analysis controls Type I error rate well and addresses many challenges posed by previous approaches. Delayed-start studies employing the proposed analysis approach could be used to provide evidence of a disease-modifying effect. This method has been communicated with FDA and has been successfully applied to actual

  11. A Novel Approach to Delayed-Start Analyses for Demonstrating Disease-Modifying Effects in Alzheimer’s Disease

    PubMed Central

    Liu-Seifert, Hong; Andersen, Scott W.; Lipkovich, Ilya; Holdridge, Karen C.; Siemers, Eric

    2015-01-01

    One method for demonstrating disease modification is a delayed-start design, consisting of a placebo-controlled period followed by a delayed-start period wherein all patients receive active treatment. To address methodological issues in previous delayed-start approaches, we propose a new method that is robust across conditions of drug effect, discontinuation rates, and missing data mechanisms. We propose a modeling approach and test procedure to test the hypothesis of noninferiority, comparing the treatment difference at the end of the delayed-start period with that at the end of the placebo-controlled period. We conducted simulations to identify the optimal noninferiority testing procedure to ensure the method was robust across scenarios and assumptions, and to evaluate the appropriate modeling approach for analyzing the delayed-start period. We then applied this methodology to Phase 3 solanezumab clinical trial data for mild Alzheimer’s disease patients. Simulation results showed a testing procedure using a proportional noninferiority margin was robust for detecting disease-modifying effects; conditions of high and moderate discontinuations; and with various missing data mechanisms. Using all data from all randomized patients in a single model over both the placebo-controlled and delayed-start study periods demonstrated good statistical performance. In analysis of solanezumab data using this methodology, the noninferiority criterion was met, indicating the treatment difference at the end of the placebo-controlled studies was preserved at the end of the delayed-start period within a pre-defined margin. The proposed noninferiority method for delayed-start analysis controls Type I error rate well and addresses many challenges posed by previous approaches. Delayed-start studies employing the proposed analysis approach could be used to provide evidence of a disease-modifying effect. This method has been communicated with FDA and has been successfully applied to

  12. Experimental Procedures for Demonstration of MicroRNA Mediated Enhancement of Functional Neuroprotective Effects of Estrogen Receptor Agonists.

    PubMed

    Chakrabarti, Mrinmay; Ray, Swapan K

    2016-01-01

    Protection of motoneurons is an important therapeutic goal in the treatment of neurological disorders. Recent reports have suggested that specific microRNAs (miRs) could modulate the expression of particular proteins for significant alterations in the pathogenesis of different neurological disorders. Thus, combination of overexpression of a specific neuroprotective miR and treatment with a neuroprotective agent could be a novel strategy for functional protection of motoneurons. The protocols described herein demonstrate that miR-7-1, a neuroprotective miR, can enhance the functional neuroprotective effects of estrogen receptor agonists such as 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole (PPT), Way 200070 (WAY), and estrogen (E2) in preventing apoptosis in A23187 calcium ionophore (CI) exposed VSC4.1 motoneurons. This article describes the protocols for the cell viability assay, transfection of VSC4.1 motoneurons with miRs, Annexin V/propidium iodide staining for apoptosis, Western blotting, patch-clamp recording of whole-cell membrane potential, and JC-1 staining for detection of mitochondrial membrane potential. Taken together, these protocols are used to demonstrate that miR-7-1 caused significant enhancement of the efficacy of estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons. PMID:26585150

  13. Towards a conceptual framework demonstrating the effectiveness of audiovisual patient descriptions (patient video cases): a review of the current literature

    PubMed Central

    2012-01-01

    Background Technological advances have enabled the widespread use of video cases via web-streaming and online download as an educational medium. The use of real subjects to demonstrate acute pathology should aid the education of health care professionals. However, the methodology by which this effect may be tested is not clear. Methods We undertook a literature review of major databases, found relevant articles relevant to using patient video cases as educational interventions, extracted the methodologies used and assessed these methods for internal and construct validity. Results A review of 2532 abstracts revealed 23 studies meeting the inclusion criteria and a final review of 18 of relevance. Medical students were the most commonly studied group (10 articles) with a spread of learner satisfaction, knowledge and behaviour tested. Only two of the studies fulfilled defined criteria on achieving internal and construct validity. The heterogeneity of articles meant it was not possible to perform any meta-analysis. Conclusions Previous studies have not well classified which facet of training or educational outcome the study is aiming to explore and had poor internal and construct validity. Future research should aim to validate a particular outcome measure, preferably by reproducing previous work rather than adopting new methods. In particular cognitive processing enhancement, demonstrated in a number of the medical student studies, should be tested at a postgraduate level. PMID:23256787

  14. A novel landscape genetic approach demonstrates the effects of human disturbance on the Udzungwa red colobus monkey (Procolobus gordonorum).

    PubMed

    Ruiz-Lopez, M J; Barelli, C; Rovero, F; Hodges, K; Roos, C; Peterman, W E; Ting, N

    2016-02-01

    A comprehensive understanding of how human disturbance affects tropical forest ecosystems is critical for the mitigation of future losses in global biodiversity. Although many genetic studies of tropical forest fragmentation have been conducted to provide insight into this issue, relatively few have incorporated landscape data to explicitly test the effects of human disturbance on genetic differentiation among populations. In this study, we use a newly developed landscape genetic approach that relies on a genetic algorithm to simultaneously optimize resistance surfaces to investigate the effects of human disturbance in the Udzungwa Mountains of Tanzania, which is an important part of a universally recognized biodiversity hotspot. Our study species is the endangered Udzungwa red colobus monkey (Procolobus gordonorum), which is endemic to the Udzungwa Mountains and a known indicator species that thrives in large and well-protected blocks of old growth forest. Population genetic analyses identified significant population structure among Udzungwa red colobus inhabiting different forest blocks, and Bayesian cluster analyses identified hierarchical structure. Our new method for creating composite landscape resistance models found that the combination of fire density on the landscape and distance to the nearest village best explains the genetic structure observed. These results demonstrate the effects that human activities are having in an area of high global conservation priority and suggest that this ecosystem is in a precarious state. Our study also illustrates the ability of our novel landscape genetic method to detect the impacts of relatively recent landscape features on a long-lived species. PMID:26374237

  15. Dynamic ground-effect measurements on the F-15 STOL and Maneuver Technology Demonstrator (S/MTD) configuration

    NASA Technical Reports Server (NTRS)

    Kemmerly, Guy T.

    1990-01-01

    A moving-model ground-effect testing method was used to study the influence of rate-of-descent on the aerodynamic characteristics for the F-15 STOL and Maneuver Technology Demonstrator (S/MTD) configuration for both the approach and roll-out phases of landing. The approach phase was modeled for three rates of descent, and the results were compared to the predictions from the F-15 S/MTD simulation data base (prediction based on data obtained in a wind tunnel with zero rate of descent). This comparison showed significant differences due both to the rate of descent in the moving-model test and to the presence of the ground boundary layer in the wind tunnel test. Relative to the simulation data base predictions, the moving-model test showed substantially less lift increase in ground effect, less nose-down pitching moment, and less increase in drag. These differences became more prominent at the larger thrust vector angles. Over the small range of rates of descent tested using the moving-model technique, the effect of rate of descent on longitudinal aerodynamics was relatively constant. The results of this investigation indicate no safety-of-flight problems with the lower jets vectored up to 80 deg on approach. The results also indicate that this configuration could employ a nozzle concept using lower reverser vector angles up to 110 deg on approach if a no-flare approach procedure were adopted and if inlet reingestion does not pose a problem.

  16. First demonstration of SiGe-based carrier-injection Mach-Zehnder modulator with enhanced plasma dispersion effect.

    PubMed

    Kim, Younghyun; Fujikata, Junichi; Takahashi, Shigeki; Takenaka, Mitsuru; Takagi, Shinichi

    2016-02-01

    We demonstrate a strained Si0.91Ge0.09-based carrier-injection Mach-Zehnder (MZ) optical modulator using the enhanced plasma dispersion effect in strained SiGe through mass modulation for the first time. The SiGe modulator has an injection current of 1.47 mA for a phase shift of π which is lower than that for a Si modulator. Also, it is expected that the injection current can be further reduced by increasing the strain and Ge fraction, enabling operation at an injection current of less than 1 mA. As an example of the dynamic characteristics, 10 Gbps modulation with clear eye opening was obtained by the pre-emphasis method. PMID:26906774

  17. Demonstration of Cost-Effective, High-Performance Computing at Performance and Reliability Levels Equivalent to a 1994 Vector Supercomputer

    NASA Technical Reports Server (NTRS)

    Babrauckas, Theresa

    2000-01-01

    The Affordable High Performance Computing (AHPC) project demonstrated that high-performance computing based on a distributed network of computer workstations is a cost-effective alternative to vector supercomputers for running CPU and memory intensive design and analysis tools. The AHPC project created an integrated system called a Network Supercomputer. By connecting computer work-stations through a network and utilizing the workstations when they are idle, the resulting distributed-workstation environment has the same performance and reliability levels as the Cray C90 vector Supercomputer at less than 25 percent of the C90 cost. In fact, the cost comparison between a Cray C90 Supercomputer and Sun workstations showed that the number of distributed networked workstations equivalent to a C90 costs approximately 8 percent of the C90.

  18. Development and Demonstration of a Computational Tool for the Analysis of Particle Vitiation Effects in Hypersonic Propulsion Test Facilities

    NASA Technical Reports Server (NTRS)

    Perkins, Hugh Douglas

    2010-01-01

    In order to improve the understanding of particle vitiation effects in hypersonic propulsion test facilities, a quasi-one dimensional numerical tool was developed to efficiently model reacting particle-gas flows over a wide range of conditions. Features of this code include gas-phase finite-rate kinetics, a global porous-particle combustion model, mass, momentum and energy interactions between phases, and subsonic and supersonic particle drag and heat transfer models. The basic capabilities of this tool were validated against available data or other validated codes. To demonstrate the capabilities of the code a series of computations were performed for a model hypersonic propulsion test facility and scramjet. Parameters studied were simulated flight Mach number, particle size, particle mass fraction and particle material.

  19. [Experimental and clinical demonstration of the antiproliferative effect of a highly purified coal tar fraction in a special gel vehicle].

    PubMed

    Bernd, A; Wehrenberg, O; Hevert, F; Holzmann, H

    1988-04-01

    In this study a combination of clinical and experimental investigations demonstrates the antiproliferative effect of the coal tar-containing preparation Berniter. From a concentration of 70 micrograms/ml onwards (= 0.35 micrograms coal tar/ml) Berniter inhibits DNA synthesis of transformed human keratinocytes in vitro. The growth inhibiting effect is reversible up to the ED50 concentration (257 micrograms Berniter/ml = 1.3 micrograms coal tar/ml). The tar-free vehicle has no identifiable effect on the proliferation of the cells at a concentration of 260 micrograms/ml. However, at higher concentrations (ED50 = 1023 micrograms/ml) the vehicle also inhibits cell growth, this inhibition being irreversible. The effect of Berniter and the tar-free vehicle on amino acid metabolism corresponds with the reduced growth rate. The ED50 concentrations (331 micrograms/ml for Berniter and 1445 micrograms/ml for the tar-free vehicle) are higher than those in the investigation of the proliferation. The clinical trial was performed in two groups of 12 and 11 patients, respectively, suffering from Psoriasis capillitii. After 3 days' topical treatment of both groups with salicylic acid for scaling, one group was treated for 4 weeks with betamethasone-17-valerate (in the following briefly called Bet-17-v), as a commercial lotion. The other group received Bet-17-v initially for 3 days and was then treated for 4 weeks with Berniter. The 4 parameters used for evaluation (erythema, scaling, infiltration and itching) showed a more significant improvement in the Berniter group than in the Bet-17-v group. Subjectively, treatment with Berniter was assessed to be preferable.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3401273

  20. An Experiment to Determine the Effectiveness of Slides and Audio-Tapes for Presenting Manipulative Demonstrations in Graphic Arts.

    ERIC Educational Resources Information Center

    Jenkins, John David

    This study compared teacher demonstrations with a slide-tape methods of presenting demonstrations in graphic arts. It involved 134 eighth grade students and four teachers in four schools. Random assignment to treatments was made by classes. Four demonstrations randomly selected from a group were (1) composing a line of type, (2) locking-up a type…

  1. Edible Astronomy Demonstrations

    NASA Astrophysics Data System (ADS)

    Lubowich, D. A.

    2006-08-01

    By using astronomy demonstrations with edible ingredients, I have been able to increase student interest and knowledge of astronomical concepts. This approach has been successful with all age groups from elementary school through college students. I will present some of the edible demonstrations I have created including using popcorn to simulate radioactivity; using chocolate, nuts, and marshmallows to illustrate density and differentiation during the formation of the planets; and making big-bang brownies or chocolate chip-cookies to illustrate the expansion of the Universe. Sometimes the students eat the results of the astronomical demonstrations. These demonstrations are an effective teaching tool and the students remember these demonstrations after they are presented.

  2. Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts.

    PubMed

    Görögh, Tibor; Quabius, Elgar S; Heidebrecht, Hans; Nagy, Andreas; Muffels, Till; Haag, Jochen; Ambrosch, Petra; Hoffmann, Markus

    2016-05-15

    A new member of the lysyl oxidase (LOX) family, lysyl oxidase-like 4 (LOXL4), is overexpressed in head and neck squamous cell carcinoma (HNSCC) compared to normal squamous epithelium. A monoclonal antibody (mAb) derived from fusion of Balb/c mouse splenocytes immunized with LOXL4 specific peptide was used to evaluate its therapeutic efficacy in 15 HNSCC cell lines associated with LOXL4 overexpression. For xenograft experiments 41 severe combined immunodeficient (SCID) mice were used to analyze LOXL4-mAb mediated tumor regression. Cell viability was analyzed using cytotoxicity-, and clonogenic-assays. Significant suppression of tumor cell growth was observed in 12 out of 15 (80%) tumor cell lines after 48 hr exposure to the mAb (LD50 of 15 µg/ml to 45 µg/ml). The effect induced by the antibody could be blocked by pre-incubation of the antibody with the peptide used for immunization of the mice and antibody generation, indicating that the effect of the antibody is specific. In mice inoculated with HNSCC cells, i.v. injections of the LOXL4-mAb resulted within 70 days in extensive tumor destruction in all treated animals whereas no tumor regression occurred in control animals. In mice pre-immunized i.v. with LOXL4-mAb and subsequently injected with HNSCC cells, tumor development was considerably delayed in contrast to non LOXL4-mAb pre-immunized animals. These results demonstrate that the LOXL4-mAb has potent antitumor activity and suggest its suitability as a therapeutic immune agent applicable to HNSCC exhibiting tumor specific upregulation of LOXL4. PMID:26756583

  3. Water extract of Triticum aestivum L. and its components demonstrate protective effect in a model of vascular dementia.

    PubMed

    Han, Hyung Soo; Jang, Jung-Hee; Jang, Jae Hee; Choi, Jung Sook; Kim, Yoon Jung; Lee, Chan; Lim, Sun Ha; Lee, Hyeong-Kyu; Lee, Jongwon

    2010-06-01

    Although vascular dementia is the second leading cause of dementia and often underdiagnosed, there are no drugs yet approved for the treatment of vascular dementia. In this study, it is demonstrated that water extract of Triticum aestivum L. (TALE) and some of its components have protective effects against vascular dementia-induced damage by preserving the myelin sheath and inhibiting astrocytic activation. The memory test used a vascular dementia model utilizing bilateral ligation of the carotid arteries of rats. TALE, some of its components, such as starch, total dietary fiber (TDF), arabinoxylan, beta-glucan, and degraded products of arabinoxylan, such as arabinose and xylose, were administered to the animals from day 8 to day 14, following the surgery. Twenty-one days after the surgery, the water maze test was performed for 5 days, and the time taken to find the platform during training trials (mean escape latency) was measured. The mean escape latency was decreased consistently in the TALE-, starch-, TDF-, arabinoxylan-, and arabinose-treated groups, compared with that in the vascular dementia group. To measure brain damage, Luxol fast blue staining and immunohistochemistry of myelin basic protein (MBP) were performed to observe myelin sheath in the white matter, and immunohistochemistry of glial fibrillary acidic protein (GFAP) was performed to observe the astrocytic reaction. Vascular dementia reduced the MBP level and increased the GFAP level. Arabinose effectively inhibited the MBP and GFAP change, whereas arabinoxylan inhibited the GFAP change only. These results suggest that TALE and some of its components can be used as a medicinal material for the development of neuroprotective agents against vascular dementia. PMID:20521983

  4. Demonstration of surface plasmons in metal island films and the effect of the surrounding medium--An undergraduate experiment

    SciTech Connect

    Orfanides, P.; Buckner, T. F.; Buncick, M. C.; Meriaudeau, F.; Ferrell, T. L.

    2000-10-01

    We present a demonstration of the surface plasmon phenomenon as it occurs in thin metal island films. The metal films are deposited on glass microscope slides. The effect of the surface plasmon resonance may be observed visually on the slide without further apparatus. Heating the film changes the shape of the islands and therefore the resonant frequency of the surface plasmon and changes the color of the film. Placing the film in a dielectric medium changes the resonance condition for the surface plasmon again and changes the color again. We show this by coating the slides with commercially available liquids with different indices of refraction. We present a theoretical model that assumes the islands are oblate spheroids. There are enough details given so that the equations can be programed and the theoretical optical absorbance can be reproduced. We also present a modification to the theory so that the shift in resonant frequency can be calculated when the spheroids are immersed in the index fluids. We describe our apparatus for making thin films and our optical spectrometer system. We then present optical absorbance measurements of thin films of both Ag and Au in air and in two liquids with different indices of refraction. (c) 2000 American Association of Physics Teachers.

  5. Levitation Kits Demonstrate Superconductivity.

    ERIC Educational Resources Information Center

    Worthy, Ward

    1987-01-01

    Describes the "Project 1-2-3" levitation kit used to demonstrate superconductivity. Summarizes the materials included in the kit. Discusses the effect demonstrated and gives details on how to obtain kits. Gives an overview of the documentation that is included. (CW)

  6. Demonstrating Reduced Gravity.

    ERIC Educational Resources Information Center

    Pearlman, Howard; And Others

    1996-01-01

    Describes the construction of the Reduced-Gravity Demonstrator, which can be used to illustrate the effects of gravity on a variety of phenomena, including the way fluids flow, flames burn, and mechanical systems behave. Presents experiments, appropriate for classroom use, to demonstrate how the behavior of common physical systems change when…

  7. Demonstrating Reduced Gravity

    NASA Technical Reports Server (NTRS)

    Pearlman, Howard; Stocker, Dennis; Gotti, Daniel; Urban, David; Ross, Howard; Sours, Thomas

    1996-01-01

    A miniature drop tower, Reduced-Gravity Demonstrator is developed to illustrate the effects of gravity on a variety of phenomena including the way fluids flow, flames burn, and mechanical systems (such as pendulum) behave. A schematic and description of the demonstrator and payloads are given, followed by suggestions for how one can build his (her) own.

  8. Development of Criteria to Measure the Extent of Implementation and the Effectiveness of Demonstration in Vocational Education. Case Studies.

    ERIC Educational Resources Information Center

    Development Associates, Inc., Arlington, VA.

    This document presents case studies of eight demonstration projects selected to assess the practicality and feasibility of a monograph for improving and measuring the impact of vocational education demonstration projects. An introduction provides background of the project that developed that monograph and information on the case studies, including…

  9. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Hambly, Gordon F.; Goldsmith, Robert H.

    1988-01-01

    Presented is a method of demonstrating the optical activity of glucose using an overhead projector and easily obtainable materials. Explores the difference between reflected and transmitted light (Tyndall Effect) using sodium thiosulfate, hydrochloric acid, and an overhead projector. (ML)

  10. Floating Magnet Demonstration.

    ERIC Educational Resources Information Center

    Wake, Masayoshi

    1990-01-01

    A room-temperature demonstration of a floating magnet using a high-temperature superconductor is described. The setup and operation of the apparatus are described. The technical details of the effect are discussed. (CW)

  11. Dynamic metabolism modelling of urban water services--demonstrating effectiveness as a decision-support tool for Oslo, Norway.

    PubMed

    Venkatesh, G; Sægrov, Sveinung; Brattebø, Helge

    2014-09-15

    Urban water services are challenged from many perspectives and different stakeholders demand performance improvements along economic, social and environmental dimensions of sustainability. In response, urban water utilities systematically give more attention to criteria such as water safety, climate change adaptation and mitigation, environmental life cycle assessment (LCA), total cost efficiency, and on how to improve their operations within the water-energy-carbon nexus. The authors of this paper collaborated in the development of a 'Dynamic Metabolism Model' (DMM). The model is developed for generic use in the sustainability assessment of urban water services, and it has been initially tested for the city of Oslo, Norway. The purpose has been to adopt a holistic systemic perspective to the analysis of metabolism and environmental impacts of resource flows in urban water and wastewater systems, in order to offer a tool for the examination of future strategies and intervention options in such systems. This paper describes the model and its application to the city of Oslo for the analysis time period 2013-2040. The external factors impacting decision-making and interventions are introduced along with realistic scenarios developed for the testing, after consultation with officials at the Oslo Water and Wastewater Works (Norway). Possible interventions that the utility intends to set in motion are defined and numerically interpreted for incorporation into the model, and changes in the indicator values over the time period are determined. This paper aims to demonstrate the effectiveness and usefulness of the DMM, as a decision-support tool for water-wastewater utilities. The scenarios considered and interventions identified do not include all possible scenarios and interventions that can be relevant for water-wastewater utilities. PMID:24880242

  12. Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability.

    PubMed

    Zhaojie, Meng; Ming, Zhang; Shengnan, Wei; Xiaojia, Bi; Hatch, Grant M; Jingkai, Gu; Li, Chen

    2014-06-01

    Low oral bioavailability of berberine due to poor solubility and membrane permeability limits its clinical use for treatment of diabetes. We developed an amorphous solid dispersion of berberine with absorption enhancer sodium caprate, referred to as Huang-Gui Solid Dispersion (HGSD) preparations, and examined them for improvement of dissolution and oral bioavailability. HGSDs were prepared by solvent evaporation, and the formulations of amorphous solid dispersions were characterized by X-ray diffraction, differential scanning calorimetry and scanning electron microscopy. According to in vitro solubility and dissolution studies, P9, the 9th production of HGSDs based on orthogonal test, was sorted out. Then pharmacokinetic behavior of P9 was evaluated by in vitro membrane permeation, in situ intestinal perfusion, and in vivo bioavailability in rats. Furthermore, the anti-diabetic effect of P9 was examined in a type 2 diabetic rat model. It was found that majority of berberine in P9 existed in an amorphous form, and its solubility and dissolution rate were significantly increased. Pharmacokinetic studies demonstrated a 3-fold increase in in vitro membrane permeation, a 4-fold increase in in situ intestinal perfusion and a 5-fold increase in vivo bioavailability of P9 compared to berberine or berberine tablets. In addition, oral administration of P9 (100mg/kg) improved glucose and lipid metabolism in diabetic rats compared to pure berberine (100mg/kg), berberine tablets (100mg/kg) or metformin (300 mg/kg) treatment. These findings indicate that P9 enhances oral bioavailability of berberine and may be a potential candidate drug for treatment of diabetes. PMID:24607213

  13. Demonstrating the effects of phonological similarity and frequency on item and order memory in Down syndrome using process dissociation.

    PubMed

    Smith, Elizabeth; Jarrold, Christopher

    2014-12-01

    It is important to distinguish between memory for item information and memory for order information when considering the nature of verbal short-term memory (vSTM) performance. Although other researchers have attempted to make this distinction between item and order memory in children, none has done so using process dissociation. This study shows that such an approach can be particularly useful and informative. Individuals with Down syndrome (DS) tend to experience a vSTM deficit. These two experiments explored whether phonological similarity (Experiment 1) and item frequency (Experiment 2) affected vSTM for item and order information in a group of individuals with DS compared with typically developing (TD) vocabulary-matched children. Process dissociation was used to obtain measures of item and order memory via Nairne and Kelley's procedure (Journal of Memory and Language, 50 (2004) 113-133). Those with DS were poorer than the matched TD group for recall of both item and order information. However, in both populations, phonologically similar items reduced order memory but enhanced item memory, whereas high-frequency items resulted in improvements in both item and order memory-effects that are in line with previous research in the adult literature. These results indicate that, despite poorer vSTM performance in DS, individuals experience phonological coding of verbal input and a contribution of long-term memory knowledge to recall. These findings inform routes for interventions for those with DS, highlighting the need to enhance both item and order memory. Moreover, this work demonstrates that process dissociation is applicable and informative for studying special populations and children. PMID:25089885

  14. The Microgravity Demonstrator

    NASA Technical Reports Server (NTRS)

    Rogers, Melissa J. B.; Wargo, Michael J.

    1999-01-01

    The Demonstrator is a tool to create microgravity conditions in your classroom. A series of demonstrations is used to provide a dramatically visual, physical connection between free-fall and microgravity conditions and to understand why various types of experiments are performed under microgravity conditions. A wealth of back-round material on free-fall, microgravity, and micro-gravity sciences is available in two educational documents available through the NASA Teacher Resource Centers: Microgravity-Activity Guide for Science, Mathematics, and Technology Education, and The Mathematics of Microgravity. The remainder of this manual is divided into five sections. The first explains how to put the Microgravity Demonstrator together. The next section introduces the individual demonstrations and discusses the underlying physical science concepts. Following that are detailed steps for conducting each demonstration to make your use of the Demonstrator most effective. Next are some ideas on how to make your own Microgravity Demonstrator. The last section is a tips and troubleshooting guide for video connections and operations. If you have one of the NASA Microgravity Demonstrators, this entire manual should be useful. If you have a copy of the Microgravity Demonstrator Videotape and would like to use that as a teaching tool, the Demonstrations and Scientific Background section of this manual will give you insight into the science areas studied in microgravity.

  15. Demonstration of a novel technique to measure two-photon exchange effects in elastic e±p scattering

    SciTech Connect

    Moteabbed, Maryam; Niroula, Megh; Raue, Brian A.; Weinstein, Lawrence B.

    2013-08-30

    difference between the incoming electron and positron beams. This systematic effect leads to the largest uncertainty in the final ratio of positron to electron scattering: R=1.027±0.005±0.05 for < Q2 >=0.206 GeV2 and 0.830 ≤ ε ≤ 0.943. We have demonstrated that the tertiary e± beam generated using this technique provides the opportunity for dramatically improved comparisons of e±p scattering, covering a significant range in both Q2 and scattering angle. Combining data with different chicane polarities will allow for detailed studies of the difference between the incoming e+ and e- beams.

  16. Demonstration of a novel technique to measure two-photon exchange effects in elastic e±p scattering

    DOE PAGESBeta

    Moteabbed, Maryam; Niroula, Megh; Raue, Brian A.; Weinstein, Lawrence B.

    2013-08-30

    between the incoming electron and positron beams. This systematic effect leads to the largest uncertainty in the final ratio of positron to electron scattering: R=1.027±0.005±0.05 for < Q2 >=0.206 GeV2 and 0.830 ≤ ε ≤ 0.943. We have demonstrated that the tertiary e± beam generated using this technique provides the opportunity for dramatically improved comparisons of e±p scattering, covering a significant range in both Q2 and scattering angle. Combining data with different chicane polarities will allow for detailed studies of the difference between the incoming e+ and e- beams.« less

  17. Demonstration of a novel technique to measure two-photon exchange effects in elastic e±p scattering

    NASA Astrophysics Data System (ADS)

    Moteabbed, M.; Niroula, M.; Raue, B. A.; Weinstein, L. B.; Adikaram, D.; Arrington, J.; Brooks, W. K.; Lachniet, J.; Rimal, Dipak; Ungaro, M.; Afanasev, A.; Adhikari, K. P.; Aghasyan, M.; Amaryan, M. J.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Bennett, R. P.; Biselli, A. S.; Bono, J.; Boiarinov, S.; Briscoe, W. J.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Cole, P. L.; Collins, P.; Contalbrigo, M.; Cortes, O.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Doughty, D.; Dupre, R.; Egiyan, H.; Fassi, L. El; Eugenio, P.; Fedotov, G.; Fegan, S.; Fersch, R.; Fleming, J. A.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Harrison, N.; Heddle, D.; Hicks, K.; Ho, D.; Holtrop, M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Keller, D.; Khandaker, M.; Kim, A.; Klein, F. J.; Koirala, S.; Kubarovsky, A.; Kubarovsky, V.; Kuhn, S. E.; Kuleshov, S. V.; Lewis, S.; Lu, H. Y.; MacCormick, M.; MacGregor, I. J. D.; Martinez, D.; Mayer, M.; McKinnon, B.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moriya, K.; Moutarde, H.; Munevar, E.; Munoz Camacho, C.; Nadel-Turonski, P.; Nasseripour, R.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L. L.; Paremuzyan, R.; Park, K.; Park, S.; Phelps, E.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Protopopescu, D.; Puckett, A. J. R.; Ripani, M.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Stepanyan, S.; Strauch, S.; Tang, W.; Taylor, C. E.; Tian, Ye; Tkachenko, S.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2013-08-01

    to study the difference between the incoming electron and positron beams. This systematic effect leads to the largest uncertainty in the final ratio of positron to electron scattering: R=1.027±0.005±0.05 for =0.206 GeV2 and 0.830⩽ɛ⩽0.943.Conclusions: We have demonstrated that the tertiary e± beam generated using this technique provides the opportunity for dramatically improved comparisons of e±p scattering, covering a significant range in both Q2 and scattering angle. Combining data with different chicane polarities will allow for detailed studies of the difference between the incoming e+ and e- beams.

  18. Demonstration of a new ICPC design with a double-effect absorption chiller in an office building in Sacramento, California[Integrated Compound Parabolic Concentrator

    SciTech Connect

    Duff, W.S.; Winston, R.; O'Gallagher, J.J.; Henkel, T.; Muschaweck, J.; Christiansen, R.; Bergquam, J.

    1999-07-01

    In 1998 two new technologies, a new ICPC solar collector and the solar operation of a double effect chiller, have been demonstrated for the first in an office building in Sacramento, California. This paper describes the demonstration project and reports on component and system performance.

  19. The Effect of Demonstrator Gender on Wind Instrument Preferences of Kindergarten, Third-Grade, and Fifth-Grade Students

    ERIC Educational Resources Information Center

    Killian, Janice N.; Satrom, Shauna L.

    2011-01-01

    This study examined possible influences of demonstrator gender on children's instrument choices. Participants (N = 104) included boys (n = 53) and girls ( n = 51) in fifth grade (n = 27), third grade (n = 41), and kindergarten (n = 36) in six intact music classes from a single elementary school. Pretest and posttest consisted of circling (Grades 3…

  20. Demonstrating the Superiority of the FCB Grid as a Tool for Students To Write Effective Advertising Strategy.

    ERIC Educational Resources Information Center

    Yssel, Johan C.

    Although the FCB (Foote, Cone, & Belding) grid was never intended to serve as an educational tool, it can be applied successfully in advertising classes to address the three areas that S. E. Moriarty considers to be the minimum for writing strategy. To demonstrate the superiority of the FCB grid as a pedagogical tool, a study analyzed strategies…

  1. Effects of Lecture, Teacher Demonstrations, Discussion and Practical Work on 10th Graders' Attitudes to Chemistry and Understanding of Electrolysis.

    ERIC Educational Resources Information Center

    Thompson, Jerome; Soyibo, Kola

    2002-01-01

    Investigates whether the use of the combination of lecture, teacher demonstrations, class discussion, and student practical work in small groups significantly improved experimental subjects' attitudes to chemistry and understanding of electrolysis more than their control group counterparts who were not exposed to practical work. Examines whether…

  2. Is Quality/Effectiveness An Empirically Demonstrable School Attribute? Statistical Aids for Determining Appropriate Levels of Analysis.

    ERIC Educational Resources Information Center

    Griffith, James

    2002-01-01

    Describes and demonstrates analytical techniques used in organizational psychology and contemporary multilevel analysis. Using these analytic techniques, examines the relationship between educational outcomes and the school environment. Finds that at least some indicators might be represented as school-level phenomena. Results imply that the…

  3. Evaluating Effectiveness: A Comparison of Federal Expectations and Local Capabilities for Evaluation among Federally Funded Model Demonstration Programs.

    ERIC Educational Resources Information Center

    DeStefano, Lizanne

    1992-01-01

    Citing the signaling and charged use distinction, examines federal expectations and need for evaluation data and extent of local capabilities to meet those expectations when secondary/transition model demonstration projects, funded by the Office of Special Education and Rehabilitation Services, were obligated to improve amount, quality, and use of…

  4. Effects of visual demonstration, verbal instructions, and prompted verbal descriptions on the performance of human subjects in conditional discriminations

    PubMed Central

    Ribes-Iñesta, Emilio; Cepeda, Ma. Luisa; Hickman, Hortencia; Moreno, Diana; Peñalosa, Eduardo

    1992-01-01

    A study was conducted to confirm prior results concerning the role of prompted verbal descriptions of visually demonstrated stimulus relations in the acquisition and transfer of identity, difference, and similarity-matching relations (Ribes et al., 1988). Four groups of human adults were trained with these three matching relations under four different procedures: (1) visual demonstration without response requirement, (2) verbal instructions, (3) visual demonstration plus prompted verbal description, and (4) visual demonstration plus verbal instructions. These procedures were presented at the beginning of the training period before subjects could respond to the experimental task. Although most subjects in the four groups acquired the conditional discrimination under the three matching relations, only those in the two instruction-related groups showed some intramodal and extramodal transfer in tests with stimuli that had not been used in training. These results suggest the importance of measuring extra-situational and trans-situational generalization, and raise the need to distinguish between formal and functional verbal factors in the regulation of human behavior. ImagesFig. 3Fig. 4 PMID:22477044

  5. The AEGIS technology demonstration for a nuclear waste repository in basalt. Assessment of effectiveness of geologic isolation systems

    NASA Astrophysics Data System (ADS)

    Dove, F. H.; Cole, C. R.; Foley, M. G.

    1982-09-01

    A technology demonstration of performance assessment techniques as applied to a nuclear waste repository in the Columbia Plateau Basalts was conducted. Hypothetical repository coordinates were selected for an acutal geographical setting on the Hanford Reservation in the state of Washington. Available information was used to establish the data base and initial hydrologic and geologic interpretations for this site-specific application. A simplified diagram of the AEGIS analyses is shown. Because an understanding of the dynamics of ground water flow is essential to the development of release scenarios and consequence analyses, a key step in the demonstration is the systems characterization contained in the conceputal model. Regional and local ground water movement patterns were defined with the aid of hydrologic computer models.

  6. The cause of cancer: biochemical defects in the cancer cell demonstrated by the effects of electromagnetic radiation, glucose and oxygen.

    PubMed

    Holt, J A

    1979-01-01

    The responses of a person carrying a cancer to 434 MHz electromagnetic radiation are such that they demonstrate that each human cell contains at least two separate respiratory pathways which can convert glucose to energy. The first pathway produces energy by an anaerobic mechanism and it can be demonstrated that this energy is used for the purpose of cell replication. The second pathway(s) produces energy from glucose by aerobic oxidative processes which can be shown to energise other cellular functions. One of these functions is that of controlling its own cell division. Other demonstrable functions of this aerobic energy producing mechanism are concerned with individual cellular repair processes, multicellular organisation and repair and the preservation of gross anatomical perfection. Release of the first or anaerobic system from supervisory control by the second or aerobic sytem(s) permits the unlimited cell division which is the phenomenon known as cancer. The available circumstantial evidence suggests that this is not the result of nuclear or chromosomal defects or mutations but is due to direct irreversible sublethal damage to the cellular aerobic glucose metabolic system whilst the anaerobic system remains intact. PMID:459964

  7. LIMB Demonstration Project Extension and Coolside Demonstration

    SciTech Connect

    Goots, T.R.; DePero, M.J.; Nolan, P.S.

    1992-11-10

    This report presents results from the limestone Injection Multistage Burner (LIMB) Demonstration Project Extension. LIMB is a furnace sorbent injection technology designed for the reduction of sulfur dioxide (SO[sub 2]) and nitrogen oxides (NO[sub x]) emissions from coal-fired utility boilers. The testing was conducted on the 105 Mwe, coal-fired, Unit 4 boiler at Ohio Edison's Edgewater Station in Lorain, Ohio. In addition to the LIMB Extension activities, the overall project included demonstration of the Coolside process for S0[sub 2] removal for which a separate report has been issued. The primary purpose of the DOE LIMB Extension testing, was to demonstrate the generic applicability of LIMB technology. The program sought to characterize the S0[sub 2] emissions that result when various calcium-based sorbents are injected into the furnace, while burning coals having sulfur content ranging from 1.6 to 3.8 weight percent. The four sorbents used included calcitic limestone, dolomitic hydrated lime, calcitic hydrated lime, and calcitic hydrated lime with a small amount of added calcium lignosulfonate. The results include those obtained for the various coal/sorbent combinations and the effects of the LIMB process on boiler and plant operations.

  8. The Comparative Effects of Teacher-Demonstration and Self-Paced Instruction on Concept Acquisition and Problem-Solving Skills of College Level Chemistry Students.

    ERIC Educational Resources Information Center

    Eniaiyeju, Paul A.

    1983-01-01

    Compared effectiveness of teacher-demonstration and self-paced modes of teaching concepts and problem-solving skills in college chemistry. Results showed the self-paced mode significantly more effective for teaching concepts and problem-solving skills. Results of an attitude test also showed that most students (N=60) preferred the self-paced…

  9. AEGIS technology demonstration for a nuclear waste repository in basalt. Assessment of effectiveness of geologic isolation systems

    SciTech Connect

    Dove, F.H.; Cole, C.R.; Foley, M.G.

    1982-09-01

    A technology demonstration of current performance assessment techniques as applied to a nuclear waste repository in the Columbia Plateau Basalts was conducted. Hypothetical repository coordinates were selected for an actual geographical setting on the Hanford Reservation in the state of Washington. Published hydrologic and geologic data used in the analyses were gathered in 1979 or earlier. The following report documents the technology demonstration in basalt. Available information has been used to establish the data base and initial hydrologic and geologic interpretations for this site-specific application. A simplified diagram of the AEGIS analyses is shown. Because an understanding of the dynamics of ground-water flow is essential to the development of release scenarios and consequence analyses, a key step in the demonstration is the systems characterization contained in the conceptual model. Regional and local ground-water movement patterns have been defined with the aid of hydrologic computer models. Hypothetical release scenarios have been developed and evaluated by a process involving expert opinion and a Geologic Simulation Model for basalt. (The Geologic Simulation Model can also be used to forecast future boundary conditions for the hydrologic simulation.) Chemical reactivity of the basalt with ground water will influence the leaching and transport of radionuclides; solubility equilibria based on available data are estimated with geochemical models. After the radionuclide concentrations are mathematically introduced into the ground-water movement patterns, waste movement patterns are outlined over elapsed time. Contaminant transport results are summarized for significant radionuclides that are hypothetically released to the accessible environment and to the biosphere.

  10. Edible Astronomy Demonstrations

    NASA Astrophysics Data System (ADS)

    Lubowich, Donald A.

    2007-12-01

    Astronomy demonstrations with edible ingredients are an effective way to increase student interest and knowledge of astronomical concepts. This approach has been successful with all age groups from elementary school through college students - and the students remember these demonstrations after they are presented. In this poster I describe edible demonstrations I have created to simulate the expansion of the universe (using big-bang chocolate chip cookies); differentiation during the formation of the Earth and planets (using chocolate or chocolate milk with marshmallows, cereal, candy pieces or nuts); and radioactivity/radioactive dating (using popcorn). Other possible demonstrations include: plate tectonics (crackers with peanut butter and jelly); convection (miso soup or hot chocolate); mud flows on Mars (melted chocolate poured over angel food cake); formation of the Galactic disk (pizza); formation of spiral arms (coffee with cream); the curvature of Space (Pringles); constellations patterns with chocolate chips and chocolate chip cookies; planet shaped cookies; star shaped cookies with different colored frostings; coffee or chocolate milk measurement of solar radiation; Oreo cookie lunar phases. Sometimes the students eat the results of the astronomical demonstrations. These demonstrations are an effective teaching tool and can be adapted for cultural, culinary, and ethnic differences among the students.

  11. Theoretical demonstration of Brillouin lasing effect in racetrack resonators based on germanium waveguides in the mid-infrared.

    PubMed

    De Leonardis, Francesco; Troia, Benedetto; Soref, Richard A; Passaro, Vittorio M N

    2016-01-15

    In this Letter, we present a theoretical investigation of integrated racetrack Brillouin lasers based on germanium waveguides that are buried in silicon nitride and operate at a wavelength of 4 μm. General design equations in a steady-state regime have been carried out to determine the threshold power and the emitted Stokes power as a function of the resonance mismatch and coupling factor. The pulling effect as induced by the Brillouin gain dispersion and the pushing effects originated by SPM and XPM effects have been accurately investigated to predict the lasing frequency. PMID:26766728

  12. Innovative technology demonstration

    SciTech Connect

    Anderson, D.B.; Luttrell, S.P.; Hartley, J.N.; Hinchee, R.

    1992-04-01

    The Innovative Technology Demonstration (ITD) program at Tinker Air Force Base (TAFB), Oklahoma City, Oklahoma, will demonstrate the overall utility and effectiveness of innovative technologies for site characterization, monitoring, and remediation of selected contaminated test sites. The current demonstration test sites include a CERCLA site on the NPL list, located under a building (Building 3001) that houses a large active industrial complex used for rebuilding military aircraft, and a site beneath and surrounding an abandoned underground tank vault used for storage of jet fuels and solvents. The site under Building 3001 (the NW Test Site) is contaminated with TCE and Cr{sup {plus}6}; the site with the fuel storage vault (the SW Tanks Site) is contaminated with fuels, BTEX and TCE. These sites and others have been identified for cleanup under the Air Force`s Installation Restoration Program (IRP). This document describes the demonstrations that have been conducted or are planned for the TAFB.

  13. Innovative technology demonstration

    SciTech Connect

    Anderson, D.B.; Luttrell, S.P. ); Hartley, J.N. ); Hinchee, R. )

    1992-04-01

    The Innovative Technology Demonstration (ITD) program at Tinker Air Force Base (TAFB), Oklahoma City, Oklahoma, will demonstrate the overall utility and effectiveness of innovative technologies for site characterization, monitoring, and remediation of selected contaminated test sites. The current demonstration test sites include a CERCLA site on the NPL list, located under a building (Building 3001) that houses a large active industrial complex used for rebuilding military aircraft, and a site beneath and surrounding an abandoned underground tank vault used for storage of jet fuels and solvents. The site under Building 3001 (the NW Test Site) is contaminated with TCE and Cr{sup {plus}6}; the site with the fuel storage vault (the SW Tanks Site) is contaminated with fuels, BTEX and TCE. These sites and others have been identified for cleanup under the Air Force's Installation Restoration Program (IRP). This document describes the demonstrations that have been conducted or are planned for the TAFB.

  14. Investigating differences in treatment effect estimates between propensity score matching and weighting: A demonstration using STAR*D trial data

    PubMed Central

    Ellis, Alan R.; Dusetzina, Stacie B.; Hansen, Richard A.; Gaynes, Bradley N.; Farley, Joel F.; Stürmer, Til

    2013-01-01

    Purpose The choice of propensity score (PS) implementation influences treatment effect estimates not only because different methods estimate different quantities, but also because different estimators respond in different ways to phenomena such as treatment effect heterogeneity and limited availability of potential matches. Using effectiveness data, we describe lessons learned from sensitivity analyses with matched and weighted estimates. Methods With subsample data (N=1,292) from Sequenced Treatment Alternatives to Relieve Depression, a 2001–2004 effectiveness trial of depression treatments, we implemented PS matching and weighting to estimate the treatment effect in the treated and conducted multiple sensitivity analyses. Results Matching and weighting both balanced covariates but yielded different samples and treatment effect estimates (matched RR 1.00, 95% CI:0.75–1.34; weighted RR 1.28, 95% CI:0.97–1.69). In sensitivity analyses, as increasing numbers of observations at both ends of the PS distribution were excluded from the weighted analysis, weighted estimates approached the matched estimate (weighted RR 1.04, 95% CI 0.77–1.39 after excluding all observations below the 5th percentile of the treated and above the 95th percentile of the untreated). Treatment appeared to have benefits only in the highest and lowest PS strata. Conclusions Matched and weighted estimates differed due to incomplete matching, sensitivity of weighted estimates to extreme observations, and possibly treatment effect heterogeneity. PS analysis requires identifying the population and treatment effect of interest, selecting an appropriate implementation method, and conducting and reporting sensitivity analyses. Weighted estimation especially should include sensitivity analyses relating to influential observations, such as those treated contrary to prediction. PMID:23280682

  15. Innovative technology demonstrations

    SciTech Connect

    Anderson, D.B.; Luttrell, S.P. ); Hartley, J.N. . Environmental Management Operations); Hinchee, R. )

    1992-08-01

    Environmental Management Operations (EMO) is conducting an Innovative Technology Demonstration Program for Tinker Air Force Base (TAFB). Several innovative technologies are being demonstrated to address specific problems associated with remediating two contaminated test sites at the base. Cone penetrometer testing (CPT) is a form of testing that can rapidly characterize a site. This technology was selected to evaluate its applicability in the tight clay soils and consolidated sandstone sediments found at TAFB. Directionally drilled horizontal wells was selected as a method that may be effective in accessing contamination beneath Building 3001 without disrupting the mission of the building, and in enhancing the extraction of contamination both in ground water and in soil. A soil gas extraction (SGE) demonstration, also known as soil vapor extraction, will evaluate the effectiveness of SGE in remediating fuels and TCE contamination contained in the tight clay soil formations surrounding the abandoned underground fuel storage vault located at the SW Tanks Site. In situ sensors have recently received much acclaim as a technology that can be effective in remediating hazardous waste sites. Sensors can be useful for determining real-time, in situ contaminant concentrations during the remediation process for performance monitoring and in providing feedback for controlling the remediation process. Following the SGE demonstration, the SGE system and SW Tanks test site will be modified to demonstrate bioremediation as an effective means of degrading the remaining contaminants in situ. The bioremediation demonstration will evaluate a bioventing process in which the naturally occurring consortium of soil bacteria will be stimulated to aerobically degrade soil contaminants, including fuel and TCE, in situ.

  16. Innovative technology demonstrations

    SciTech Connect

    Anderson, D.B.; Hartley, J.N.; Luttrell, S.P.

    1992-04-01

    Currently, several innovative technologies are being demonstrated at Tinker Air Force Base (TAFB) to address specific problems associated with remediating two contaminated test sites at the base. Cone penetrometer testing (CPT) is a form of testing that can rapidly characterize a site. This technology was selected to evaluate its applicability in the tight clay soils and consolidated sandstone sediments found at TAFB. Directionally drilled horizontal wells have been successfully installed at the US Department of Energy's (DOE) Savannah River Site to test new methods of in situ remediation of soils and ground water. This emerging technology was selected as a method that may be effective in accessing contamination beneath Building 3001 without disrupting the mission of the building, and in enhancing the extraction of contamination both in ground water and in soil. A soil gas extraction (SGE) demonstration, also known as soil vapor extraction, will evaluate the effectiveness of SGE in remediating fuels and TCE contamination contained in the tight clay soil formations surrounding the abandoned underground fuel storage vault located at the SW Tanks Site. In situ sensors have recently received much acclaim as a technology that can be effective in remediating hazardous waste sites. Sensors can be useful for determining real-time, in situ contaminant concentrations during the remediation process for performance monitoring and in providing feedback for controlling the remediation process. A demonstration of two in situ sensor systems capable of providing real-time data on contamination levels will be conducted and evaluated concurrently with the SGE demonstration activities. Following the SGE demonstration, the SGE system and SW Tanks test site will be modified to demonstrate bioremediation as an effective means of degrading the remaining contaminants in situ.

  17. Innovative technology demonstrations

    SciTech Connect

    Anderson, D.B.; Hartley, J.N.; Luttrell, S.P.

    1992-04-01

    Currently, several innovative technologies are being demonstrated at Tinker Air Force Base (TAFB) to address specific problems associated with remediating two contaminated test sites at the base. Cone penetrometer testing (CPT) is a form of testing that can rapidly characterize a site. This technology was selected to evaluate its applicability in the tight clay soils and consolidated sandstone sediments found at TAFB. Directionally drilled horizontal wells have been successfully installed at the US Department of Energy`s (DOE) Savannah River Site to test new methods of in situ remediation of soils and ground water. This emerging technology was selected as a method that may be effective in accessing contamination beneath Building 3001 without disrupting the mission of the building, and in enhancing the extraction of contamination both in ground water and in soil. A soil gas extraction (SGE) demonstration, also known as soil vapor extraction, will evaluate the effectiveness of SGE in remediating fuels and TCE contamination contained in the tight clay soil formations surrounding the abandoned underground fuel storage vault located at the SW Tanks Site. In situ sensors have recently received much acclaim as a technology that can be effective in remediating hazardous waste sites. Sensors can be useful for determining real-time, in situ contaminant concentrations during the remediation process for performance monitoring and in providing feedback for controlling the remediation process. A demonstration of two in situ sensor systems capable of providing real-time data on contamination levels will be conducted and evaluated concurrently with the SGE demonstration activities. Following the SGE demonstration, the SGE system and SW Tanks test site will be modified to demonstrate bioremediation as an effective means of degrading the remaining contaminants in situ.

  18. Change point analysis of phosphorus trends in the Illinois River (Oklahoma) demonstrates the effects of watershed management.

    PubMed

    Scott, J Thad; Haggard, Brian E; Sharpley, Andrew N; Romeis, J Joshua

    2011-01-01

    Detecting water quality improvements following watershed management changes is complicated by flow-dependent concentrations and nonlinear or threshold responses that are difficult to detect with traditional statistical techniques. In this study, we evaluated the long-term trends (1997-2009) in total P (TP) concentrations in the Illinois River of Oklahoma, and some of its major tributaries, using flow-adjusted TP concentrations and regression tree analysis to identify specific calendar dates in which change points in P trends may have occurred. Phosphorus concentrations at all locations were strongly correlated with stream flow. Flow-adjusted TP concentrations increased at all study locations in the late 1990s, but this trend was related to a change in monitoring practices where storm flow samples were specifically targeted after 1998. Flow-adjusted TP concentrations decreased in the two Illinois River sites after 2003. This change coincided with a significant decrease in effluent TP concentrations originating with one of the largest municipal wastewater treatment facilities in the basin. Conversely, flow-adjusted TP concentrations in one tributary increased, but this stream received treated effluent from a wastewater facility where effluent TP did not decrease significantly over the study period. Results of this study demonstrate how long-term trends in stream TP concentrations are difficult to quantify without consistent long-term monitoring strategies and how flow adjustment is likely mandatory for examining these trends. Furthermore, the study demonstrates how detecting changes in long-term water quality data sets requires statistical methods capable of identifying change point and nonlinear responses. PMID:21712594

  19. Zebrafish Locomotor Responses Demonstrate Irritant Effects of Fine Particulate Matter Sources and a Role for TRPA1

    EPA Science Inventory

    Fine particulate matter (PM) air pollution is a complex mixture of chemicals, the composition of which is determined by contributing sources, and has been linked to cardiopulmonary dysfunction. These effects stem in part from the irritating properties of PM constituents, which ...

  20. The Effect of Prenatal Hypoxia on Brain Development: Short- and Long-Term Consequences Demonstrated in Rodent Models

    ERIC Educational Resources Information Center

    Golan, Hava; Huleihel, Mahmoud

    2006-01-01

    Hypoxia (H) and hypoxia-ischemia (HI) are major causes of foetal brain damage with long-lasting behavioral implications. The effect of hypoxia has been widely studied in human and a variety of animal models. In the present review, we summarize the latest studies testing the behavioral outcomes following prenatal hypoxia/hypoxia-ischemia in rodent…

  1. Simple Research Paradigm for Demonstrating Subliminal Pschodynamic Activation: Effects of Oedipal Stimuli on Dart-Throwing Accuracy in College Males

    ERIC Educational Resources Information Center

    Silverman, Lloyd H.; And Others

    1978-01-01

    Four experiments were carried out in which "subliminal psychodynamic activation" effects, used for studying the relationship between psychopathology and unconscious conflict, were sought out from male college students. Results were discussed for their bearing on subliminal research and research in personality. (Editor/RK)

  2. Field Demonstration of Horizontal Infill Drilling Using Cost-effective Integrated Reservoir Modeling--Mississippian Carbonates, Central Kansas

    SciTech Connect

    Saibal Bhattacharya

    2005-08-31

    Mississippian carbonate reservoirs have produced in excess of 1 billion barrels of oil in Kansas accounting for over 16% of the state's production. With declining production from other age reservoirs, the contribution of Mississippian reservoirs to Kansas's oil production has risen to 43% as of 2004. However, solution-enhanced features such as vertical shale intervals extending from the karst erosional surface at the top introduce complexities/compartmentalizations in Mississippian carbonate reservoirs. Coupled with this, strong water drives charge many of these reservoirs resulting in limited drainage from vertical wells due to high water cuts after an initial period of low water production. Moreover, most of these fields are operated by small independent operators without access to the knowledge bank of modern research in field characterization and exploitation/development practices. Thus, despite increasing importance of Mississippian fields to Kansas production, these fields are beset with low recovery factors and high abandonment rates leaving significant resources in the ground. Worldwide, horizontal infill wells have been successful in draining compartmentalized reservoirs with limited pressure depletion. The intent of this project was to demonstrate the application of horizontal wells to successfully exploit the remaining potential in mature Mississippian fields of the mid-continent. However, it is of critical importance that for horizontal wells to be economically successful, they must be selectively targeted. This project demonstrated the application of initial and secondary screening methods, based on publicly available data, to quickly shortlist fields in a target area for detailed studies to evaluate their potential to infill horizontal well applications. Advanced decline curve analyses were used to estimate missing well-level production data and to verify if the well produced under unchanging bottom-hole conditions--two commonly occurring data

  3. Demonstrations in Introductory Geophysics

    NASA Astrophysics Data System (ADS)

    Schramm, K. A.; Stein, S.; van der Lee, S.; Swafford, L.; Klosko, E.; Delaughter, J.; Wysession, M.

    2005-12-01

    Geophysical concepts are challenging to teach at introductory levels, because students need to understand both the underlying physics and its geological application. To address this, our introductory courses include class demonstrations and experiments to demonstrate underlying physical principles and their geological applications. Demonstrations and experiments have several advantages over computer simulations. First, computer simulations "work" even if the basic principle is wrong. In contrast, simple demonstrations show that a principle is physically correct, rather than a product of computer graphics. Second, many students are unfamiliar with once-standard experiments demonstrating ideas of classical physics used in geophysics. Demonstrations are chosen that we consider stimulating, relevant, inexpensive, and easy to conduct in a non-lab classroom. These come in several groups. Many deal with aspects of seismic waves, using springs, light beams, and other methods such as talking from outside the room to illustrate the frequency dependence of diffraction (hearing but not seeing around a corner). Others deal with heat and mass transfer, such as illustrating fractional crystallization with apple juice and the surface/volume effect in planetary evolution with ice. Plate motions are illustrated with paper cutouts showing effects like motion on transform faults and how the Euler vector geometry changes a plate boundary from spreading, to strike-slip, to convergence along the Pacific-North America boundary from the Gulf of California to Alaska. Radioactive decay is simulated by having the class rise and sit down as a result of coin flips (one tail versus two gives different decay rates and hence half lives). This sessions' goal of exchanging information about demonstrations is an excellent idea: some of ours are described on http://www.earth.nwu.edu/people/seth/202.

  4. The anodic emitter effect and its inversion demonstrated by temperature measurements at doped and undoped tungsten electrodes

    NASA Astrophysics Data System (ADS)

    Hoebing, T.; Bergner, A.; Hermanns, P.; Mentel, J.; Awakowicz, P.

    2016-04-01

    The admixture of a small amount of emitter oxides, e.g. \\text{Th}{{\\text{O}}2} , \\text{L}{{\\text{a}}2}{{\\text{O}}3} or \\text{C}{{\\text{e}}2}{{\\text{O}}3} to tungsten generates the so-called emitter effect. It reduces the work function of tungsten cathodes, that are applied in high intensity discharge (HID) lamps. After leaving the electrode bulk and moving to the surface, a monolayer of Th, La, or Ce atoms is formed on the surface, which reduces the effective work function ϕ. Depending on the coverage of the electrode, the effective reduction in ϕ is subjected to the thermal desorption of the monolayer from the hot electrode surface. The thermal desorption of emitter atoms from the cathode is compensated not only by the supply from the interior of the electrode and by surface diffusion of the emitter material to its tip, but also to a large extent by a repatriation of the emitter ions from the plasma by the strong electric field in front of the cathode. Yet, an emitter ion current from the arc discharge to the anode may only be present, if the anode is cold enough to refrain from thermionic emission. Therefore, the ability of emitter oxides to reduce the temperature of tungsten anodes is only given for a moderate temperature so that the thermal desorption is low and an additional ion current is present in front of the anode. A higher electrode temperature leads to their evaporation and to an inversion of the emitter effect, which increases the temperature of the respective anodes in comparison with pure tungsten anodes. Within this article, the emitter effect of doped tungsten anodes and the transition to its inversion is investigated for thoriated, lanthanated, and ceriated tungsten electrodes by measurements of the electrode temperature in dependence on the discharge current. It is shown for a lanthanated and a ceriated anode that the emitter effect is sustained by an ion current at anode temperatures at which the thermal evaporation of emitter material

  5. Crystalline structure and magnetic behavior of the Ni41Mn39In12Co8 alloy demonstrating giant magnetocaloric effect

    NASA Astrophysics Data System (ADS)

    Madiligama, A. S. B.; Ari-Gur, P.; Shavrov, V. G.; Koledov, V. V.; Calder, S.; Mashirov, A. V.; Kamantsev, A. P.; Dilmieva, E. T.; Gonzalez-Legarreta, L.; Grande, B. H.; Vega, V. V.; Kayani, A.

    2016-08-01

    Magnetic cooling is a green cooling technology, which is more energy efficient than existing fluid-compression cooling machines. Ni41Mn39In12Co8 alloy, which demonstrates promising magnetocaloric performances, was investigated using neutron diffraction and thermomagnetic measurements. The austenite structure is cubic L21 (Fm\\bar{3}m), while that of the martensite is a mix of 8 and 6 M modulated monoclinic structures (P\\quad 1\\quad 2/m\\quad 1). The austenitic site occupancy refinements reveal that all substituting Co atoms occupy Ni-sites. Most Mn atoms (65%) are in the Mn-sites and the rest go to In-sites (about 35%) and Ni-sites (less than 5%). This disorder of the magnetic atoms (Mn, Ni and Co) in the austenitic phase remains unchanged during the martensitic transition. The distortions of the interatomic distances due to the modulation of the martensitic structures further enhance the disorder in the magnetic interactions. Thermomagnetic measurements indicate that the austenitic phase is ferromagnetic. Cooling to below 250 K, where the alloy loses its ferromagnetic nature, and down to 50 K, the lack of any antiferromagnetic Bragg peaks suggests no antiferromagnetic ordering in the martensitic phase. At very low temperatures in the martensitic phase, spin glass magnetic nature is identified by magnetic measurements, and the spin-glass transition temperature is ∼19 K.

  6. Demonstration of Effects on Tropical Cyclone Forecasts with a High Resolution Global Model from Variation in Cumulus Convection Parameterization

    NASA Technical Reports Server (NTRS)

    Miller, Timothy L.; Robertson, Franklin R.; Cohen, Charles; Mackaro, Jessica

    2009-01-01

    The Goddard Earth Observing System Model, Version 5 (GEOS-5) is a system of models that have been developed at Goddard Space Flight Center to support NASA's earth science research in data analysis, observing system modeling and design, climate and weather prediction, and basic research. The work presented used GEOS-5 with 0.25o horizontal resolution and 72 vertical levels (up to 0.01 hP) resolving both the troposphere and stratosphere, with closer packing of the levels close to the surface. The model includes explicit (grid-scale) moist physics, as well as convective parameterization schemes. Results will be presented that will demonstrate strong dependence in the results of modeling of a strong hurricane on the type of convective parameterization scheme used. The previous standard (default) option in the model was the Relaxed Arakawa-Schubert (RAS) scheme, which uses a quasi-equilibrium closure. In the cases shown, this scheme does not permit the efficient development of a strong storm in comparison with observations. When this scheme is replaced by a modified version of the Kain-Fritsch scheme, which was originally developed for use on grids with intervals of order 25 km such as the present one, the storm is able to develop to a much greater extent, closer to that of reality. Details of the two cases will be shown in order to elucidate the differences in the two modeled storms.

  7. Effects of Lecture, Teacher Demonstrations, Discussion and Practical Work on 10th Graders' Attitudes to Chemistry and Understanding of Electrolysis

    NASA Astrophysics Data System (ADS)

    Thompson, Jerome; Soyibo, Kola

    2002-01-01

    This study investigated: (a) whether the use of the combination of lecture, teacher demonstrations, class discussion and student practical work in small groups significantly improved the experimental subjects' attitudes to chemistry and understanding of electrolysis more than their control group counterparts who were not exposed to practical work; and (b) whether there were statistically significant differences in their performance on electrolysis linked to their treatment, gender and post-test attitudes to chemistry. The sample was comprised of 138 Jamaican 10th graders in two high schools in St Catherine. The Attitudes to Chemistry Questionnaire and an Understanding of Electrolysis Test (UET) were used for data collection. The results showed that the experimental subjects' post-test attitudes to chemistry were statistically significantly better than those of their control group counterparts; the experimental groups' post-test mean scores on the multiple and structured items on the UET were statistically significantly better than those of the control groups; there was a positive, statistically significant but weak relationship between the experimental subjects' treatment and performance on the multiple and structured items, while the relationship between the control subjects' treatment and performance on both items was not significant.

  8. A Case of Palmoplantar Pustulosis Induced by Certolizumab Pegol: New Anti-TNF-alpha Demonstrates the Same Class Effect.

    PubMed

    Shelling, Michael L; Vitiello, Magalys; Lanuti, Emma L; Miteva, Maria; Romanelli, Paolo; Kerdel, Francisco A

    2012-08-01

    The development of de novo psoriasis in patients treated with tumor necrosis factor-alpha antagonists is well recognized. The authors hereby report a case of palmplantar pustular psoriasis in a patient with rheumatoid arthritis treated with etanercept. The condition responded to topical steroids but re-occurred upon treating the patient with certolizumab pegol. This strongly suggests that the development of de novo psoriasis is a class effect. PMID:22916313

  9. Demonstrating marketing accountability.

    PubMed

    Gombeski, William R; Britt, Jason; Taylor, Jan; Riggs, Karen; Wray, Tanya; Adkins, Wanda; Springate, Suzanne

    2008-01-01

    Pressure on health care marketers to demonstrate effectiveness of their strategies and show their contribution to organizational goals is growing. A seven-tiered model based on the concepts of structure (having the right people, systems), process (doing the right things in the right way), and outcomes (results) is discussed. Examples of measures for each tier are provided and the benefits of using the model as a tool for measuring, organizing, tracking, and communicating appropriate information are provided. The model also provides a framework for helping management understand marketing's value and can serve as a vehicle for demonstrating marketing accountability. PMID:19064476

  10. Can we demonstrate that breast cancer “Integrative Oncology” is effective? A methodology to evaluate the effectiveness of integrative oncology offered in community clinics

    PubMed Central

    Standish, Leanna J.; Sweet, Erin; Naydis, Eleonora; Andersen, M. Robyn

    2016-01-01

    Background Many women diagnosed with breast cancer receive both standard cancer treatment and care from providers trained in the emerging field of medicine called ‘integrative oncology’ (IO) in which science-based complementary and alternative medical1 therapies are prescribed by physicians. The effectiveness of IO services has not been fully studied, so is yet unknown. Purpose Determine if a matched case-controlled prospective outcomes study evaluating the efficacy and safety of breast cancer IO care is feasible. Methods Methodological proof of principle requires demonstration that 1) it is possible to find matched control breast cancer patients using the Surveillance, Epidemiology and End Results (SEER) Program’s western Washington Cancer Surveillance System (CSS), and 2) an IO clinic can recruit breast cancer patients into a matched controlled study. Results A pilot study was conducted in 2008 (N=14) to determine if matched controlled women could be identified in the western Washington SEER database. All 14 women who were approached agreed to participate. The cases were matched to the CSS along five variables - age and stage at diagnosis, race, marital and ER/PR status. Multiple matches were found for 12 of the 14 participants. Conclusion A prospective cohort study with a matched comparison group is a feasible and potentially rigorous study design with high patient acceptability. It may provide valuable data for the evaluation of the effectiveness of IO care on patient health, relapse rate, and health-related quality of life (HRQOL). A federally funded matched-case controlled outcomes study is currently underway at Bastyr University and the Fred Hutchinson Cancer Research Center. PMID:22740079

  11. Numerical demonstration of surfactant concentration-dependent capillarity and viscosity effects on infiltration from a constant flux line source

    NASA Astrophysics Data System (ADS)

    Henry, Eric J.; Smith, James E.

    2006-09-01

    SummarySurface infiltration line sources can deliver surfactant solutions for agricultural purposes or for use in subsurface remediation. Though the prediction of water distribution below a line source has received considerable attention in the scientific literature, little has been has been reported on how infiltration of surfactant solution from a line source differs from water infiltration. Few numerical models are capable of simulating surfactant-induced changes in moisture characteristic and hydraulic conductivity properties of unsaturated soil, so it is difficult to assess the importance of these effects when designing surfactant application schemes. We investigated surfactant infiltration behavior by using the variably-saturated flow and transport model HYDRUS-2D [Simunek, J., Sejna, M., van Genuchten, M.Th., 1999. The HYDRUS-2D software package for simulating the two-dimensional movement of water, heat, and multiple solutes in variably-saturated media, Version 2.0. IGWMC-TPS-53C. International Ground Water Modeling Center, Colorado School of Mines, Golden, CO] which was modified by [Henry, E.J., Smith, J.E., Warrick, A.W., 2002. Two-dimensional modeling of flow and transport in the vadose zone with surfactant-induced flow. Water Resour. Res. 38. DOI: doi:10.1029/2001WR000674] to incorporate surfactant effects on unsaturated flow. Significant differences were found between pure water and surfactant solution infiltration into a fine sand that was initially at residual moisture content. The surfactant solution wetted a larger area, both horizontally and vertically, relative to water, while the distribution of water within the wetted zone was more uniform than in the surfactant system. The surfactant system exhibited transient localized drainage and rewetting caused by surfactant-induced capillary pressure gradients within the wetting front. A standard unsaturated flow model (i.e., one that does not include surfactant effects on flow) is not capable of

  12. Triclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformans

    PubMed Central

    Movahed, Elaheh; Tan, Grace Min Yi; Munusamy, Komathy; Yeow, Tee Cian; Tay, Sun Tee; Wong, Won Fen; Looi, Chung Yeng

    2016-01-01

    Objectives: Cryptococcus neoformans is an opportunistic fungus that causes fatal meningoencephalitis especially in AIDS patients. There is an increasing need for discovery of new anti-cryptococcal drugs due to emergence of resistance cases in recent years. In this study, we aim to elucidate the antifungal effect of triclosan against C. neoformans. Methods: Minimal inhibitory concentration (MIC) of triclosan in different C. neoformans strains was first examined. The in vitro interactions between triclosan and two standard anti-fungal drugs (amphotericin B and fluconazole) were further evaluated by microdilution checkerboard assay. Mechanism of triclosan fungicidal activity was then investigated by viewing the cell morphology under transmission electron microscope. Results: We reported that triclosan potently inhibited the growth of C. neoformans. A combination of triclosan with amphotericin B or with fluconazole enhanced their fungicidal effects. Triclosan-treated C. neoformans displayed characteristics such as nuclear chromatin condensation, extensive intracellular vacuolation and mitochondrial swelling, indicating that triclosan triggered apoptosis-like cell death. Conclusion: In summary, our report suggests triclosan as an independent drug or synergent for C. neoformans treatment. PMID:27047474

  13. Toxicological and biochemical analyses demonstrate no toxic effect of Cry1C and Cry2A to Folsomia candida

    PubMed Central

    Yang, Yan; Chen, Xiuping; Cheng, Lisheng; Cao, Fengqin; Romeis, Jörg; Li, Yunhe; Peng, Yufa

    2015-01-01

    Collembolans are common soil arthropods that may be exposed to insecticidal proteins produced in genetically engineered (GE) plants by ingestion of crop residues or root exudates. In the present study, a dietary exposure assay was validated and used to assess the lethal and sublethal effects of two Bacillus thuringiensis (Bt) insecticidal proteins, Cry1C and Cry2A, on Folsomia candida. Using the insecticidal compounds potassium arsenate (PA), protease inhibitor (E-64), and Galanthus nivalis agglutinin (GNA) mixed into Baker’s yeast, we show that the assay used can detect adverse effects on F. candida. Survival and development were significantly reduced when F. candida was fed a diet containing PA, E-64, and GNA at 9, 75, and 100 μg/g diet, respectively, but not when fed a diet containing 300 μg/g Cry1C or 600 μg/g Cry2A. The activities of test antioxidant-, detoxification-, and digestion-related enzymes in F. candida were unaltered by a diet containing 300 μg/g Cry1C or 600 μg/g Cry2A, but were significantly increased by a diet containing 75 μg/g E-64. The results confirm that Cry1C and Cry2A are not toxic to F. candida at concentrations that are much higher than those encountered under field conditions. PMID:26494315

  14. Field-induced networks of weak-links: an experimental demonstration that the paramagnetic Meissner effect is inherent to granularity

    NASA Astrophysics Data System (ADS)

    Ortiz, W. A.; Lisboa-Filho, P. N.; Passos, W. A. C.; Araújo-Moreira, F. M.

    2001-10-01

    In this article we report a direct observation that the paramagnetic Meissner effect (PME, also called Wohlleben effect), presented by some superconducting samples, is an inherent consequence of granularity in superconductors. The experiments reported here were performed using high-quality thin films of Nb and YBa 2Cu 3O 7- δ. A network of randomly distributed SS‧S weak-links was induced on the film by application of a small perpendicular DC magnetic field. The high demagnetization factor arising from this geometry, forces magnetic flux to penetrate into the sample, establishing a pattern of magnetic dendrites. By changing the external field we can adjust the critical current strength of the weak-links, thus controlling the magnetic response of the induced network. In this way we have tuned the temperature dependence of the field-cooled magnetization. An important conclusion supported by the experiments is that PME results from a competition between positive and negative magnetic responses generated by different levels of granularity in a multigranular system. This is in accordance with previous experiments correlating PME and the dynamic reentrance exhibited by a Josephson junction array, a particularly ordered granular system.

  15. Toxicological and biochemical analyses demonstrate no toxic effect of Cry1C and Cry2A to Folsomia candida.

    PubMed

    Yang, Yan; Chen, Xiuping; Cheng, Lisheng; Cao, Fengqin; Romeis, Jörg; Li, Yunhe; Peng, Yufa

    2015-01-01

    Collembolans are common soil arthropods that may be exposed to insecticidal proteins produced in genetically engineered (GE) plants by ingestion of crop residues or root exudates. In the present study, a dietary exposure assay was validated and used to assess the lethal and sublethal effects of two Bacillus thuringiensis (Bt) insecticidal proteins, Cry1C and Cry2A, on Folsomia candida. Using the insecticidal compounds potassium arsenate (PA), protease inhibitor (E-64), and Galanthus nivalis agglutinin (GNA) mixed into Baker's yeast, we show that the assay used can detect adverse effects on F. candida. Survival and development were significantly reduced when F. candida was fed a diet containing PA, E-64, and GNA at 9, 75, and 100 μg/g diet, respectively, but not when fed a diet containing 300 μg/g Cry1C or 600 μg/g Cry2A. The activities of test antioxidant-, detoxification-, and digestion-related enzymes in F. candida were unaltered by a diet containing 300 μg/g Cry1C or 600 μg/g Cry2A, but were significantly increased by a diet containing 75 μg/g E-64. The results confirm that Cry1C and Cry2A are not toxic to F. candida at concentrations that are much higher than those encountered under field conditions. PMID:26494315

  16. Regular and sporadic demonstration of space weather effects on Earth's upper atmosphere according to dragging of low satellites

    NASA Astrophysics Data System (ADS)

    Koshkin, Nikolay; Ryabov, Mikhail; Komendant, Volodymyr

    Dynamics drag of low orbital artificial satellites as development indicators of a influence of space weather on the upper atmosphere of the Earth is considered. The investigated period which actuates: phases of decrease and a long minimum of the 23rd cycle of solar activity (2005-2008yy), increase phase and a maximum of the 24th cycle of activity (2009-2013yy). In dynamics of drags of all investigated artificial satellites effects as results of x-ray and ultra-violet radiation of high-power solar flares, fluxes of electrons and protons, coronal mass ejection (СМЕ) are distinctly shown. Influences of magnetic storms with the sudden and gradual beginning on dynamics of satellite's drag are investigated. The particular interest represents studying of the periods of common effects of radiation and magnetic storms influence. In the absence of extreme developments of space weather in character of artificial satellites drags various periodic wave processes are shown. Among them there are long-term variations of a geomagnetic field, the gravitational and thermal tidal phenomena in the upper atmosphere etc. The results of identification of the impact of these wave processes on the nature of the artificial satellites drag will be presented.

  17. Demonstration of. beta. -adrenergic receptors and catecholamine-mediated effects on cell proliferation in embryonic palatal tissue

    SciTech Connect

    Pisano, M.M.

    1986-01-01

    The ability of catecholamines to modulate cell proliferation, differentiation and morphogenesis in other systems, and modulate adenylate cyclase activity in the developing palate during the period of cellular differentiation, made it of interest to determine their involvement in palatal ontogenesis. Catecholamines exert their physiologic effects via interaction with distinct membrane-bound receptors, one class being the B-adrenergic receptors which are coupled to stimulation of adenylate cyclase and the generation of cAMP. A direct radioligand binding technique utilizing the B-adrenergic antagonist (/sup 3/H)-dihydroalprenolol ((/sup 3/H)-DHA) was employed in the identification of B-adrenergic receptors in the developing murine secondary palate. Specific binding of (/sup 3/H)-DHA in embryonic (day 13) palatal tissue homogenates was saturable and of high affinity. The functionality of B-adrenergic receptor binding sites was assessed from the ability of embryonic palate mesenchmyal cells in vitro to respond to catecholamines with elevations of cAMP. Embryonic palate mesenchymal cells responded to various B-adrenergic catecholamine agonists with significant, dose-dependent accumulations of intracellular cAMP. Embryonic (day 13) maxillary tissue homogenates were analyzed for the presence of catecholamines by high performance liquid chromatography and radioenzymatic assay. Since normal palatal and craniofacial morphogenesis depends on proper temporal and spatial patterns of growth, the effect of B-adrenergic catecholamines on embryonic palate mesenchymal cell proliferation was investigated.

  18. An intervention study demonstrates effects of MC4R genotype on boar taint and performances of growing-finishing pigs.

    PubMed

    Van den Broeke, A; Aluwé, M; Tuyttens, F A M; Ampe, B; Vanhaecke, L; Wauters, J; Janssens, S; Coussé, A; Buys, N; Millet, S

    2015-03-01

    The Asp298Asn polymorphism of the melanocortin-4 receptor (MC4R) in pigs is known to affect economically important traits such as growth rate and backfat thickness. We have assessed the possible use of this polymorphism as a molecular marker to perform genetic selection toward lower boar taint levels without compromising growth performance and carcass and meat quality in commercial boars and gilts. Homozygous boars and gilts of the AA genotype and GG genotype were compared in an intervention study with a 2 × 2 design to assess main effects and possible interactions between sex and genotype. The concentrations of the 3 boar taint compounds androstenone ( = 0.044), skatole ( = 0.049), and indole ( = 0.006) were significantly higher in fat of AA boars compared to GG boars. However, no effect on the sensory analysis of the fat samples could be observed. Between 20 and 115 kg BW, AA pigs showed higher ADFI than GG pigs ( < 0.001). An interaction between genotype and sex was observed for ADG ( = 0.044): AA boars had a significantly higher ADG than GG boars but there was no significant difference between the gilts. Daily lean meat gain tended to be higher in boars compared to gilts ( = 0.051), independent of genotype. Similarly, boars showed higher G:F compared to gilts ( < 0.001), without effect of genotype. Genotype and sex affected several carcass quality parameters but there was no interaction. Pigs of the AA genotype displayed a lower dressing percentage ( = 0.005), lower ham width ( = 0.024), lower muscle thickness ( = 0.011), and higher fat thickness ( < 0.001), resulting in a lower lean meat percentage ( < 0.001) in comparison with GG pigs. Gilts had a significantly higher dressing percentage ( < 0.001), higher muscle thickness ( < 0.001), higher ham width ( < 0.001), and lower ham angle ( < 0.001) compared to boars. Other than the boar taint compounds, meat quality was not affected by genotype. Pork of gilts was darker ( = 0.014) and less exudative during

  19. Effects of space flight on the immunohistochemical demonstration of connexin 26 and connexin 43 in the postpartum uterus of rats

    NASA Technical Reports Server (NTRS)

    Burden, H. W.; Zary, J.; Alberts, J. R.

    1999-01-01

    The effect of space flight in a National Aeronautics and Space Administration shuttle was studied in pregnant rats. Rats were launched on day 11 of gestation and recovered on day 20 of gestation. Pregnancy was allowed to proceed to term and rats delivered vaginally on days 22-23, although flight animals required more labour contractions to complete the delivery process. Pups were placed with foster dams and connexin 26 and 43 were examined in the uterus of flight animals approximately 3 h after delivery. Space flight did not affect uterine connexin 26, localized primarily in epithelial cells of the endometrium, but decreased connexin 43, the major gap junction protein in the myometrium. It is suggested that decreased connexin 43 alters synchronization and coordination of labour contractions, resulting in a requirement for more contractions to complete the delivery process.

  20. Laboratory demonstration of a prozone-like effect in HRP2-detecting malaria rapid diagnostic tests: implications for clinical management

    PubMed Central

    2011-01-01

    Background Malaria rapid diagnostic tests (RDTs) are now widely used for prompt on-site diagnosis in remote endemic areas where reliable microscopy is absent. Aberrant results, whereby negative test results occur at high parasite densities, have been variously reported for over a decade and have led to questions regarding the reliability of the tests in clinical use. Methods In the first trial, serial dilutions of recombinant HRP2 antigen were tested on an HRP2-detectiing RDT. In a second trial, serial dilutions of culture-derived Plasmodium falciparum parasites were tested against three HRP2-detecting RDTs. Results A prozone-like effect occurred in RDTs at a high concentration of the target antigen, histidine-rich protein-2 (above 15,000 ng/ml), a level that corresponds to more than 312000 parasites per μL. Similar results were noted on three RDT products using dilutions of cultured parasites up to a parasite density of 25%. While reduced line intensity was observed, no false negative results occurred. Conclusions These results suggest that false-negative malaria RDT results will rarely occur due to a prozone-like effect in high-density infections, and other causes are more likely. However, RDT line intensity is poorly indicative of parasite density in high-density infections and RDTs should, therefore, not be considered quantitative. Immediate management of suspected severe malaria should rely on clinical assessment or microscopy. Evaluation against high concentrations of antigen should be considered in malaria RDT product development and lot-release testing, to ensure that very weak or false negative results will not occur at antigen concentrations that might be seen clinically. PMID:21957869

  1. Coaching and Demonstration of Evidence-Based Book-Reading Practices: Effects on Head Start Teachers' Literacy-Related Behaviors and Classroom Environment

    ERIC Educational Resources Information Center

    Gettinger, Maribeth; Stoiber, Karen C.

    2016-01-01

    This study examined the effects of coaching with versus without demonstrations of evidence-based book-reading practices on teachers' use of strategies during independent book-reading periods. A total of 22 Head Start teachers were randomly assigned to one of two cohorts. One cohort (n = 12) participated in biweekly coaching sessions that included…

  2. Infrared spectroscopic demonstration of cooperative and anti-cooperative effects in C-H--O hydrogen bonds

    NASA Astrophysics Data System (ADS)

    Samanta, Amit K.; Chakraborty, Tapas

    Matrix isolation infrared spectra of 1,2-cyclohexanedione (1,2-CHD) and 3-methyl-1,2-cyclohexanedione are measured in a nitrogen matrix at 8K temperature. The spectra reveal that in the matrix environment both the molecules exist exclusively in monohydroxy tautomeric forms with an intramolecular O-H⋯O=C hydrogen bonding. In the case of 3-MeCD, the fundamental of OH stretching νO--H band appears more red-shifted with larger bandwidth indicating that the intramolecular O-H⋯O hydrogen bond of this molecule is somewhat stronger compared to that of 1,2-CD. Electronic structure calculations at B3LYP/6-311++G∗∗ and MP2/cc-pVTZ levels predict that the monohydroxy tautomer of 1,2-CD is nearly 4.5 kcal/mol more stable than the corresponding diketo tautomer, but in the case of 3-MeCD, the stability difference between the diketo and preferred enol tautomer is more than 7.5 kcal/mol. Analysis of the geometric parameters reveals that the excess stabilization of the latter originates as a result of formation of an intramolecular O⋯H-O⋯H-C type interconnected hydrogen bonding network involving a methyl C-H bond, which interact in a cooperative fashion. The predicted infrared spectrum shows that the formation of such hydrogen bonding network causes large blue-shifting of the H-bonded methyl νC--H transition, and this spectral prediction matches well with the features displayed in the measured spectrum.For intermolecular case, 1:1 complex between 1,2-cyclohexanedione and chloroform have been studied. Here two types of complex is possible, interconnected and bifurcated. In the interconnected complex a cooperative stabilizing effect and in the bifurcated complex an anti-cooperative destabilizing effect of the C-H⋯O hydrogen bond on the intramolecular O-H⋯O bond is observable. In the room temperature solution phase of FTIR spectra, the anti-cooperative complex is observable.

  3. Infrared spectroscopic demonstration of cooperative and anti-cooperative effects in C-H--O hydrogen bonds

    NASA Astrophysics Data System (ADS)

    Samanta, Amit K.; Chakraborty, Tapas

    2010-06-01

    Matrix isolation infrared spectra of 1,2-cyclohexanedione (1,2-CHD) and 3-methyl-1,2-cyclohexanedione are measured in a nitrogen matrix at 8K temperature. The spectra reveal that in the matrix environment both the molecules exist exclusively in monohydroxy tautomeric forms with an intramolecular O-H⋯O=C hydrogen bonding. In the case of 3-MeCD, the fundamental of OH stretching νO--H band appears more red-shifted with larger bandwidth indicating that the intramolecular O-H⋯O hydrogen bond of this molecule is somewhat stronger compared to that of 1,2-CD. Electronic structure calculations at B3LYP/6-311++G∗∗ and MP2/cc-pVTZ levels predict that the monohydroxy tautomer of 1,2-CD is nearly 4.5 kcal/mol more stable than the corresponding diketo tautomer, but in the case of 3-MeCD, the stability difference between the diketo and preferred enol tautomer is more than 7.5 kcal/mol. Analysis of the geometric parameters reveals that the excess stabilization of the latter originates as a result of formation of an intramolecular O⋯H-O⋯H-C type interconnected hydrogen bonding network involving a methyl C-H bond, which interact in a cooperative fashion. The predicted infrared spectrum shows that the formation of such hydrogen bonding network causes large blue-shifting of the H-bonded methyl νC--H transition, and this spectral prediction matches well with the features displayed in the measured spectrum.For intermolecular case, 1:1 complex between 1,2-cyclohexanedione and chloroform have been studied. Here two types of complex is possible, interconnected and bifurcated. In the interconnected complex a cooperative stabilizing effect and in the bifurcated complex an anti-cooperative destabilizing effect of the C-H⋯O hydrogen bond on the intramolecular O-H⋯O bond is observable. In the room temperature solution phase of FTIR spectra, the anti-cooperative complex is observable.

  4. Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo.

    PubMed

    Ruszová, Ema; Cheel, José; Pávek, Stanislav; Moravcová, Martina; Hermannová, Martina; Matějková, Ilona; Spilková, Jiřina; Velebný, Vladimír; Kubala, Lukáš

    2013-09-01

    Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of normal human dermal fibroblasts (NHDF) in vitro and to exhibit skin photo-protection in vivo. The HPLC-UV-MS analysis of the EA preparation identified three major polyphenol groups: tannins (oenothein B), phenolic acids (gallic and chlorogenic acids) and flavonoids. EA extract increased the cell viability of senescent NHDF induced by serum deprivation. It diminished connective tissue growth factor and fibronectin gene expressions in senescent NHDF. Down-regulation of the UV-induced release of both matrix metalloproteinase-1 and -3 and the tissue inhibitor of matrix metalloproteinases-1 and -2, and also down-regulation of the gene expression of hyaluronidase 2 were observed in repeatedly UV-irradiated NHDF after EA extract treatment. Interestingly, EA extract diminished the down-regulation of sirtuin 1 dampened by UV-irradiation. The application of EA extract using a sub-irritating dose protected skin against UV-induced erythema formation in vivo. In summary, EA extract diminished stress-induced effects on NHDF, particularly on connective tissue growth factor, fibronectin and matrix metalloproteinases. These results collectively suggest that EA extract may possess anti-aging properties and that the EA polyphenols might account for these benefits. PMID:23817638

  5. Surface Treatments that Demonstrate a Significant Positive Effect on the Shear Bond Strength of Repaired Resin-modified Glass Ionomer.

    PubMed

    Welch, D; Seesengood, B; Hopp, C

    2015-01-01

    This study examined surface treatment options used to repair resin-modified glass ionomer (RMGI; GC Fuji II LC, GC America). Two hundred forty specimens were equally divided into four different water/temperature cycling environmental conditions. The conditions were 1) five-minute delay, 2) one-week delay with one thermocycle, 3) 500 thermocycles, and 4) 24-hour delay in a dry environment, followed by 500 thermocycles. Within each of the condition groups, the specimens were equally divided again into three different surface treatment groups with 20 specimens in each. The treatment groups comprised A) sanding, B) sanding and acid etch, and C) sanding, acid etch, and dental bonding agent. Our results suggest that RMGI is extremely susceptible to the simultaneous exposure of temperature cycling and water during the first 24 hours. Our main results reflect that 1) during the first five minutes after the initial placement, the surface treatments made no difference in terms of the shear bond strength (NS); and 2) when we weakened the RMGI by exposing it to water and temperature cycling immediately after initial placement, each of the treatments (Aeffect on the micromechanical bond strength of the repair. PMID:25575195

  6. A robust demonstration of the cognate facilitation effect in first-language and second-language naming.

    PubMed

    Sheng, Li; Lam, Boji Pak Wing; Cruz, Diana; Fulton, Aislynn

    2016-01-01

    The cognate facilitation effect refers to the phenomenon that in bilinguals performance on various vocabulary tasks is enhanced for cross-linguistic cognates as opposed to noncognates. However, research investigating the presence of the cognate advantage in bilingual children remains limited. Most studies with children conducted to date has not included a control group or rigorously designed stimuli, which may jeopardize the validity and robustness of the emerging evidence. The current study addressed these methodological problems by examining performance in picture naming tasks in 34 4- to 7-year-old Spanish-English bilinguals and 52 Mandarin-English bilinguals as well as 37 English-speaking monolinguals who served as controls. Stimuli were controlled for phonology, word frequency, and length. The Spanish-English bilinguals performed better for cognates than for noncognates and exhibited a greater number of doublet responses (i.e., providing correct responses in both languages) in naming cognate targets than in naming noncognates. The control groups did not show differences in performance between the two sets of words. These findings provide compelling evidence that cross-linguistic similarities at the phonological level allow bootstrapping of vocabulary learning. PMID:26463463

  7. Experimental demonstration of the coexistence of spin Hall and Rashba effects in β -tantalum/ferromagnet bilayers

    NASA Astrophysics Data System (ADS)

    Allen, Gary; Manipatruni, Sasikanth; Nikonov, Dmitri E.; Doczy, Mark; Young, Ian A.

    2015-04-01

    We have measured the spin torques of β -tantalum /C o20F e60B20 bilayers versus Ta thickness at room temperature using a ferromagnetic resonance (FMR) technique. A significant fieldlike spin torque originating from Ta was identified, which is constant and independent of Ta thickness. Because of this constant torque, the spin Hall coefficient θSH needs to be calculated from the ratio of the symmetric component of the FMR signal to the slope of the antisymmetric component with Ta thickness, from which a value of -0.11 ±0.01 was determined. The saturation magnetization of the CoFeB layers for samples deposited with Ta was found to be smaller than that of a single CoFeB layer, with values of 1.84 ±0.01 and 1.92 ±0.01 T, respectively. The origin of the fieldlike torque is ascribed to an interface spin-orbit coupling, or Rashba effect, due to the strength and constancy of the torque with Ta thickness. From fitting measured data to a semiclassical diffusion model that includes interface spin-orbit coupling, we have determined the spin diffusion length for β-tantalum to be 2.5 nm.

  8. A case study of bats and white-nose syndrome demonstrating how to model population viability with evolutionary effects.

    PubMed

    Maslo, Brooke; Fefferman, Nina H

    2015-08-01

    Ecological factors generally affect population viability on rapid time scales. Traditional population viability analyses (PVA) therefore focus on alleviating ecological pressures, discounting potential evolutionary impacts on individual phenotypes. Recent studies of evolutionary rescue (ER) focus on cases in which severe, environmentally induced population bottlenecks trigger a rapid evolutionary response that can potentially reverse demographic threats. ER models have focused on shifting genetics and resulting population recovery, but no one has explored how to incorporate those findings into PVA. We integrated ER into PVA to identify the critical decision interval for evolutionary rescue (DIER) under which targeted conservation action should be applied to buffer populations undergoing ER against extinction from stochastic events and to determine the most appropriate vital rate to target to promote population recovery. We applied this model to little brown bats (Myotis lucifugus) affected by white-nose syndrome (WNS), a fungal disease causing massive declines in several North American bat populations. Under the ER scenario, the model predicted that the DIER period for little brown bats was within 11 years of initial WNS emergence, after which they stabilized at a positive growth rate (λ = 1.05). By comparing our model results with population trajectories of multiple infected hibernacula across the WNS range, we concluded that ER is a potential explanation of observed little brown bat population trajectories across multiple hibernacula within the affected range. Our approach provides a tool that can be used by all managers to provide testable hypotheses regarding the occurrence of ER in declining populations, suggest empirical studies to better parameterize the population genetics and conservation-relevant vital rates, and identify the DIER period during which management strategies will be most effective for species conservation. PMID:25808080

  9. Medicago truncatula Mutants Demonstrate the Role of Plant Calcium Oxalate Crystals as an Effective Defense against Chewing Insects1

    PubMed Central

    Korth, Kenneth L.; Doege, Sarah J.; Park, Sang-Hyuck; Goggin, Fiona L.; Wang, Qin; Gomez, S. Karen; Liu, Guangjie; Jia, Lingling; Nakata, Paul A.

    2006-01-01

    Calcium oxalate is the most abundant insoluble mineral found in plants and its crystals have been reported in more than 200 plant families. In the barrel medic Medicago truncatula Gaertn., these crystals accumulate predominantly in a sheath surrounding secondary veins of leaves. Mutants of M. truncatula with decreased levels of calcium oxalate crystals were used to assess the defensive role of this mineral against insects. Caterpillar larvae of the beet armyworm Spodoptera exigua Hübner show a clear feeding preference for tissue from calcium oxalate-defective (cod) mutant lines cod5 and cod6 in choice test comparisons with wild-type M. truncatula. Compared to their performance on mutant lines, larvae feeding on wild-type plants with abundant calcium oxalate crystals suffer significantly reduced growth and increased mortality. Induction of wound-responsive genes appears to be normal in cod5 and cod6, indicating that these lines are not deficient in induced insect defenses. Electron micrographs of insect mouthparts indicate that the prismatic crystals in M. truncatula leaves act as physical abrasives during feeding. Food utilization measurements show that, after consumption, calcium oxalate also interferes with the conversion of plant material into insect biomass during digestion. In contrast to their detrimental effects on a chewing insect, calcium oxalate crystals do not negatively affect the performance of the pea aphid Acyrthosiphon pisum Harris, a sap-feeding insect with piercing-sucking mouthparts. The results confirm a long-held hypothesis for the defensive function of these crystals and point to the potential value of genes controlling crystal formation and localization in crop plants. PMID:16514014

  10. Demonstration of the Effect of Generic Anatomical Divisions versus Clinical Protocols on Computed Tomography Dose Estimates and Risk Burden

    PubMed Central

    Moorin, Rachael E.; Gibson, David A. J.; Forsyth, Rene K.; Fox, Richard

    2014-01-01

    Objective Choosing to undertake a CT scan relies on balancing risk versus benefit, however risks associated with CT scanning have generally been limited to broad anatomical locations, which do not provided adequate information to evaluate risk against benefit. Our study aimed to determine differences in radiation dose and risk estimates associated with modern CT scanning examinations when computed for clinical protocols compared with those using anatomical area. Methods Technical data were extracted from a tertiary hospital Picture Archiving Communication System for random samples of 20–40 CT examinations per adult clinical CT protocol. Organ and whole body radiation dose were calculated using ImPACT Monte Carlo simulation software and cancer incidence and mortality estimated using BEIR VII age and gender specific lifetime attributable risk weights. Results Thirty four unique CT protocols were identified by our study. When grouped according to anatomic area the radiation dose varied substantially, particularly for abdominal protocols. The total estimated number of incident cancers and cancer related deaths using the mean dose of anatomical area were 86 and 69 respectively. Using more specific protocol doses the estimates rose to 214 and 138 incident cancers and cancer related deaths, at least doubling the burden estimated. Conclusions Modern CT scanning produces a greater diversity of effective doses than much of the literature describes; where a lack of focus on actual scanning protocols has produced estimates that do not reflect the range and complexity of modern CT practice. To allow clinicians, patients and policy makers to make informed risk versus benefit decisions the individual and population level risks associated with modern CT practices are essential. PMID:24878841

  11. Changing Feeding Regimes To Demonstrate Flexible Biogas Production: Effects on Process Performance, Microbial Community Structure, and Methanogenesis Pathways

    PubMed Central

    Mulat, Daniel Girma; Jacobi, H. Fabian; Feilberg, Anders; Adamsen, Anders Peter S.; Richnow, Hans-Hermann

    2015-01-01

    Flexible biogas production that adapts biogas output to energy demand can be regulated by changing feeding regimes. In this study, the effect of changes in feeding intervals on process performance, microbial community structure, and the methanogenesis pathway was investigated. Three different feeding regimes (once daily, every second day, and every 2 h) at the same organic loading rate were studied in continuously stirred tank reactors treating distiller's dried grains with solubles. A larger amount of biogas was produced after feeding in the reactors fed less frequently (once per day and every second day), whereas the amount remained constant in the reactor fed more frequently (every 2 h), indicating the suitability of the former for the flexible production of biogas. Compared to the conventional more frequent feeding regimes, a methane yield that was up to 14% higher and an improved stability of the process against organic overloading were achieved by employing less frequent feeding regimes. The community structures of bacteria and methanogenic archaea were monitored by terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA and mcrA genes, respectively. The results showed that the composition of the bacterial community varied under the different feeding regimes, and the observed T-RFLP patterns were best explained by the differences in the total ammonia nitrogen concentrations, H2 levels, and pH values. However, the methanogenic community remained stable under all feeding regimes, with the dominance of the Methanosarcina genus followed by that of the Methanobacterium genus. Stable isotope analysis showed that the average amount of methane produced during each feeding event by acetoclastic and hydrogenotrophic methanogenesis was not influenced by the three different feeding regimes. PMID:26497462

  12. Demonstrating the Effect of Particle Impact Dampers on the Random Vibration Response and Fatigue Life of Printed Wiring Assemblies

    NASA Technical Reports Server (NTRS)

    Knight, Brent; Montgomery, Randall; Geist, David; Hunt, Ron; LaVerde, Bruce; Towner, Robert

    2013-01-01

    In a recent experimental study, small Particle Impact Dampers (PID) were bonded directly to the surface of printed circuit board (PCB) or printed wiring assemblies (PWA), reducing the random vibration response and increasing the fatigue life. This study provides data verifying practicality of this approach. The measured peak strain and acceleration response of the fundamental out of plane bending mode was significantly attenuated by adding a PID device. Attenuation of this mode is most relevant to the fatigue life of a PWA because the local relative displacements between the board and the supported components, which ultimately cause fatigue failures of the electrical leads of the board-mounted components are dominated by this mode. Applying PID damping at the board-level of assembly provides mitigation with a very small mass impact, especially as compared to isolation at an avionics box or shelf level of assembly. When compared with other mitigation techniques at the PWA level (board thickness, stiffeners, constrained layer damping), a compact PID device has the additional advantage of not needing to be an integral part of the design. A PID can simply be bonded to heritage or commercial off the shelf (COTS) hardware to facilitate its use in environments beyond which it was originally qualified. Finite element analysis and test results show that the beneficial effect is not localized and that the attenuation is not due to the simple addition of mass. No significant, detrimental reduction in frequency was observed. Side-by-side life testing of damped and un-damped boards at two different thicknesses (0.070" and 0.090") has shown that the addition of a PID was much more significant to the fatigue life than increasing the thickness. High speed video, accelerometer, and strain measurements have been collected to correlate with analytical results.

  13. Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro.

    PubMed

    Seeger, T; Worek, F; Szinicz, L; Thiermann, H

    2007-04-20

    Organophosphorus (OP) pesticides or nerve agents cause severe intoxication by inhibition of acetylcholinesterase, finally resulting in death due to respiratory failure. The phrenic nerve diaphragm preparation is considered as the classic model to investigate the effect of OP intoxications and oxime treatment at the neuromuscular junction. However, this preparation is unsuitable for larger species or for muscle strips from biopsies where no nerve is available for stimulation. An alternative technique is the indirect field stimulation of muscles containing intramuscular nerve branches only. The proposed method by Wolthuis et al. [Wolthuis, O.L., Vanwersch, R.A.P., Van Der Wiel, H.J., 1981. The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man. Eur. J. Pharmacol. 70, 355-369] was modified and experimentally reevaluated in isolated mouse diaphragms. To confirm that electrical field stimulation technique induced muscle contraction only via the neuromuscular endplate the nicotinic antagonists pancuronium or d-tubocurarine (1microM) were given. In the presence of a nicotinic antagonist hardly any contraction was blocked after indirect field stimulation technique with very short pulses (5micros, <0.6A), in contrast to direct muscle stimulation (broader pulse width, or higher amplitude >0.6A). During paraoxon circumfusion (20min, 1micromol/l) muscle force generation by indirect stimulation was almost completely blocked. Restoration of paralyzed muscle function to 80% of initial values could be achieved after paraoxon wash out (20min) and circumfusion with obidoxime (1micromol/l, 20min). This data correspond quite well to data shown earlier when using conventional nerve stimulation techniques. PMID:17250944

  14. The Blowgun Demonstration Experiment

    ERIC Educational Resources Information Center

    Tsukamoto, Koji; Uchino, Masanori

    2008-01-01

    We have found that a simple demonstration experiment using a match or a cotton swab and a drinking straw or an acrylic pipe serves as an effective introduction to dynamics. The most basic apparatus has a cotton swab serving as a dart and the straw as the blowgun. When blown from a starting point near the exit end of the straw, the cotton swab does…

  15. Astronomy LITE Demonstrations

    NASA Astrophysics Data System (ADS)

    Brecher, Kenneth

    2006-12-01

    Project LITE (Light Inquiry Through Experiments) is a materials, software, and curriculum development project. It focuses on light, optics, color and visual perception. According to two recent surveys of college astronomy faculty members, these are among the topics most often included in the large introductory astronomy courses. The project has aimed largely at the design and implementation of hands-on experiences for students. However, it has also included the development of lecture demonstrations that employ novel light sources and materials. In this presentation, we will show some of our new lecture demonstrations concerning geometrical and physical optics, fluorescence, phosphorescence and polarization. We have developed over 200 Flash and Java applets that can be used either by teachers in lecture settings or by students at home. They are all posted on the web at http://lite.bu.edu. For either purpose they can be downloaded directly to the user's computer or run off line. In lecture demonstrations, some of these applets can be used to control the light emitted by video projectors to produce physical effects in materials (e.g. fluorescence). Other applets can be used, for example, to demonstrate that the human percept of color does not have a simple relationship with the physical frequency of the stimulating source of light. Project LITE is supported by Grant #DUE-0125992 from the NSF Division of Undergraduate Education.

  16. LIMB Demonstration Project Extension

    SciTech Connect

    Not Available

    1989-06-15

    The basic goal of the Limestone Injection Multistage Burner (LIMB) demonstration is to extend LIMB technology development to a full- scale application on a representative wall-fired utility boiler. The successful retrofit of LIMB to an existing boiler is expected to demonstrate that (a) reductions of 50 percent or greater in SO{sub x} and NO{sub x} emissions can be achieved at a fraction of the cost of add-on FGD systems, (b) boiler reliability, operability, and steam production can be maintained at levels existing prior to LIMB retrofit, and (c) technical difficulties attributable to LIMB operation, such as additional slagging and fouling, changes in ash disposal requirements, and an increased particulate load, can be resolved in a cost-effective manner. The primary fuel to be used will be an Ohio bituminous coal having a nominal sulfur content of 3 percent or greater.

  17. LIMB Demonstration Project Extension

    SciTech Connect

    Not Available

    1989-11-15

    The basic goal of the Limestone Injection Mitigation Burner (LIMB) demonstration is to extend LIMB technology development to a full- scale application on a representative wall-fired utility boiler. The successful retrofit of LIMB to an existing boiler is expected to demonstrate that (a) reductions of 50 percent or greater in SO{sub x} and NO{sub x} emissions can be achieved at a fraction of the cost of add-on FGD systems, (b) boiler reliability, operability, and steam production can be maintained at levels existing prior to LIMB retrofit, and (c) technical difficulties attributable to LIMB operation, such as additional slagging and fouling, changes in ash disposal requirements, and an increased particulate load, can be resolved in a cost-effective manner. The primary fuel to be used will be an Ohio bituminous coal having a nominal sulfur content of 3 percent or greater.

  18. LIMB Demonstration Project Extension

    SciTech Connect

    Not Available

    1989-03-15

    The basic goal of the Limestone Injection Multistage Burner (LIMB) demonstration is to extend LIMB technology development to a full- scale application on a representative wall-fired utility boiler. The successful retrofit of LIMB to an existing boiler is expected to demonstrate that (a) reductions of 50 percent or greater in SO{sub x} and NO{sub x} emissions can be achieved at a fraction of the cost of add-on FGD systems, (b) boiler reliability, operability, and steam production can be maintained at levels existing prior to LIMB retrofit, and (c) technical difficulties attributable to LIMB operation, such as additional slagging and fouling, changes in ash disposal requirements, and an increased particulate load, can be resolved in a cost-effective manner. The primary fuel to be used will be an Ohio bituminous coal having a nominal sulfur content of 3 percent or greater.

  19. LIMB Demonstration Project Extension

    SciTech Connect

    Not Available

    1988-12-15

    The basic goal of the Limestone Injection Multistage Burner (LIMB) demonstration is to extend LIMB technology development to a full- scale application on a representative wall-fired utility boiler. The successful retrofit of LIMB to an existing boiler is expected to demonstrate that (a) reductions of 50 percent or greater in SO{sub x} and NO{sub x} emissions can be achieved at a fraction of the cost of add-on FGD systems, (b) boiler reliability, operability, and steam production can be maintained at levels existing prior to LIMB retrofit, and (c) technical difficulties attributable to LIMB operation, such as additional slagging and fouling, changes in ash disposal requirements, and an increased particulate load, can be resolved in a cost-effective manner. The primary fuel to be used will be an Ohio bituminous coal having a nominal sulfur content of 3 percent or greater.

  20. Nucla CFB Demonstration Project

    SciTech Connect

    Not Available

    1990-12-01

    This report documents Colorado-Ute Electric Association's Nucla Circulating Atmospheric Fluidized-Bed Combustion (AFBC) demonstration project. It describes the plant equipment and system design for the first US utility-size circulating AFBC boiler and its support systems. Included are equipment and system descriptions, design/background information and appendices with an equipment list and selected information plus process flow and instrumentation drawings. The purpose of this report is to share the information gathered during the Nucla circulating AFBC demonstration project and present it so that the general public can evaluate the technical feasibility and cost effectiveness of replacing pulverized or stoker-fired boiler units with circulating fluidized-bed boiler units. (VC)

  1. The comparative effects of teacher-demonstration and self-paced instruction on concept acquisition and problem-solving skills of college level chemistry students

    NASA Astrophysics Data System (ADS)

    Eniaiyeju, Paul A.

    A comparison is made of the relative effectiveness of teacher-demonstration and self-paced modes of teaching concepts and problem-solving skills in chemistry. Sixty students were randomized into two treatment groups. A self-paced instructional package was used by subjects in the self-paced group. Subjects in the second group were taught by a teacher who used the same self-paced package. Results of the analyses of variance performed showed that the selfpaced mode of instruction was significantly more effective for teaching concepts and problem-solving skills. An attitude test was given at the end of the third unit. Results of the test showed that most students preferred the self-paced instruction to the teacher-demonstration method.

  2. A Fluorescence Lecture Demonstration.

    ERIC Educational Resources Information Center

    Bozzelli, Joseph W.; Kemp, Marwin

    1982-01-01

    Describes fluorescence demonstrations related to several aspects of molecular theory and quantitized energy levels. Demonstrations use fluorescent chemical solutions having luminescence properties spanning the visible spectrum. Also describes a demonstration of spontaneous combustion of familiar substances in chlorine. (JN)

  3. Herschel's Interference Demonstration.

    ERIC Educational Resources Information Center

    Perkalskis, Benjamin S.; Freeman, J. Reuben

    2000-01-01

    Describes Herschel's demonstration of interference arising from many coherent rays. Presents a method for students to reproduce this demonstration and obtain beautiful multiple-beam interference patterns. (CCM)

  4. Data demonstrating the effects of build orientation and heat treatment on fatigue behavior of selective laser melted 17-4 PH stainless steel.

    PubMed

    Yadollahi, Aref; Simsiriwong, Jutima; Thompson, Scott M; Shamsaei, Nima

    2016-06-01

    Axial fully-reversed strain-controlled ([Formula: see text]) fatigue experiments were performed to obtain data demonstrating the effects of building orientation (i.e. vertical versus horizontal) and heat treatment on the fatigue behavior of 17-4 PH stainless steel (SS) fabricated via Selective Laser Melting (SLM) (Yadollahi et al., submitted for publication [1]). This data article provides detailed experimental data including cyclic stress-strain responses, variations of peak stresses during cyclic deformation, and fractography of post-mortem specimens for SLM 17-4 PH SS. PMID:26955653

  5. Data demonstrating the effects of build orientation and heat treatment on fatigue behavior of selective laser melted 17–4 PH stainless steel

    PubMed Central

    Yadollahi, Aref; Simsiriwong, Jutima; Thompson, Scott M.; Shamsaei, Nima

    2016-01-01

    Axial fully-reversed strain-controlled (R=−1) fatigue experiments were performed to obtain data demonstrating the effects of building orientation (i.e. vertical versus horizontal) and heat treatment on the fatigue behavior of 17–4 PH stainless steel (SS) fabricated via Selective Laser Melting (SLM) (Yadollahi et al., submitted for publication [1]). This data article provides detailed experimental data including cyclic stress-strain responses, variations of peak stresses during cyclic deformation, and fractography of post-mortem specimens for SLM 17–4 PH SS. PMID:26955653

  6. Whirl/whip demonstration

    NASA Technical Reports Server (NTRS)

    Grissom, R.

    1985-01-01

    Fluid flow in bearings and seals, set in motion by shaft rotation, generates dynamic forces which may result in a well recognized instability known as whirl and whip. These are lateral, forward precessional, self excited, subsynchronous vibrations in which the amplitude may vary from very small to nearly the limit of the bearing or seal clearances. Oil whirl in lubricated bearings, in particular, typically occurs at somewhat less than half rotative speed. As the rotative speed increases, the frequency relationship remains constant until the whirl frequency approaches the first balance resonance. Now the whirl is smoothly replaced by whip at a nearly constant frequency asymptotically approaching first balance resonance, independent of increasing rotative speed. Changes in bearing/seal radial loading can permit, prevent, or eliminate this instability. The oil whirl/whip rig demonstrates the effects of fluid dynamic forces generated by the rotating shaft. At low rotative speeds, this produces changes of the journal static equilibrium position within the bearing. The demonstrator shows the relationship between any load direction and the average journal equilibrium position. At higher rotative speeds, the instability threshold is observed as a function of unidirectional radial load, unbalance, and rotor configuration.

  7. PFBC Utility Demonstration Project

    SciTech Connect

    Not Available

    1992-11-01

    This report provides a summary of activities by American Electric Power Service Corporation during the first budget period of the PFBC Utility Demonstration Project. In April 1990, AEP signed a Cooperative Agreement with the US Department of Energy to repower the Philip Sporn Plant, Units 3 4 in New Haven, West Virginia, with a 330 KW PFBC plant. The purpose of the program was to demonstrate and verify PFBC in a full-scale commercial plant. The technical and cost baselines of the Cooperative Agreement were based on a preliminary engineering and design and a cost estimate developed by AEP subsequent to AEP's proposal submittal in May 1988, and prior to the signing of the Cooperative Agreement. The Statement of Work in the first budget period of the Cooperative Agreement included a task to develop a preliminary design and cost estimate for erecting a Greenfield plant and to conduct a comparison with the repowering option. The comparative assessment of the options concluded that erecting a Greenfield plant rather than repowering the existing Sporn Plant could be the technically and economically superior alternative. The Greenfield plant would have a capacity of 340 MW. The ten additional MW output is due to the ability to better match the steam cycle to the PFBC system with a new balance of plant design. In addition to this study, the conceptual design of the Sporn Repowering led to several items which warranted optimization studies with the goal to develop a more cost effective design.

  8. A Comprehensive Assessment of the Effects of Bt Cotton on Coleomegilla maculata Demonstrates No Detrimental Effects by Cry1Ac and Cry2Ab

    PubMed Central

    Li, Yunhe; Romeis, Jörg; Wang, Ping; Peng, Yufa; Shelton, Anthony M.

    2011-01-01

    The ladybird beetle, Coleomegilla maculata (DeGeer), is a common and abundant predator in many cropping systems. Its larvae and adults are predaceous, feeding on aphids, thrips, lepidopteran larvae and plant tissues, such as pollen. Therefore, this species is exposed to insecticidal proteins expressed in insect-resistant, genetically engineered cotton expressing Cry proteins derived from Bacillus thuringiensis (Bt). A tritrophic bioassay was conduced to evaluate the potential impact of Cry2Ab- and Cry1Ac-expressing cotton on fitness parameters of C. maculata using Bt-susceptible and -resistant larvae of Trichoplusia ni as prey. Coleomegilla maculata survival, development time, adult weight and fecundity were not different when they were fed with resistant T. ni larvae reared on either Bt or control cotton. To ensure that C. maculata were not sensitive to the tested Cry toxins independent from the plant background and to add certainty to the hazard assessment, C. maculata larvae were fed artificial diet incorporated with Cry2Ab, Cry1Ac or both at >10 times higher concentrations than in cotton tissue. Artificial diet containing E-64 was included as a positive control. No differences were detected in any life-table parameters between Cry protein-containing diet treatments and the control diet. In contrast, larvae of C. maculata fed the E-64 could not develop to the pupal stage and the 7-d larval weight was significantly negatively affected. In both feeding assays, the stability and bioactivity of Cry proteins in the food sources were confirmed by ELISA and sensitive-insect bioassays. Our results show that C. maculata is not affected by Bt cotton and is not sensitive to Cry2Ab and Cry1Ac at concentrations exceeding the levels in Bt cotton, thus demonstrating that Bt cotton will pose a negligible risk to C. maculata. More importantly, this study demonstrates a comprehensive system for assessing the risk of genetically modified plants on non-target organisms. PMID

  9. Tested Demonstrations. A Chemiluminescence Demonstration - Oxalyl Chloride Oxidation.

    ERIC Educational Resources Information Center

    Gilber, George L., Ed.

    1979-01-01

    This inexpensive, effective chemiluminescence demonstration requires minimal preparation. It is based on the oxidation of oxalyl chloride by hydrogen peroxide in the presence of an appropriate fluorescent sensitizer. The reaction mechanism is not completely understood. (BB)

  10. Dual-modality imaging demonstrates the enhanced antitumoral effect of herpes simplex virus-thymidine kinase/ganciclovir plus gemcitabine combination therapy on cholangiocarcinoma

    PubMed Central

    WANG, JIANFENG; LI, ANG; JIN, MEI; ZHANG, FAN; LI, XIAOLING

    2016-01-01

    Herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV) therapy is one of the most promising therapeutic strategies for the treatment of cholangiocarcinoma, which is the second most common hepatobiliary cancer. The aim of the present study was to evaluate the enhanced therapeutic effects of HSV-TK/GCV with gemcitabine on cholangiocarcinoma. QBC939 cholangiocarcinoma cells and mouse models of cholangiocarcinoma (established via tumor xenografts) received one of the following treatments: i) Gemcitabine therapy (3 µg/ml); ii) HSV-TK/GCV monotherapy; iii) HSV-TK/GCV + gemcitabine; and iv) control group, treated with phosphate-buffered saline. Cell proliferation was quantified using MTT assay and post-treatment tumor alterations were monitored using ultrasound imaging and optical imaging. For the in vitro experiments, the MTT assays demonstrated that the relative cell viabilities in the gene therapy, gemcitabine and gemcitabine + gene groups were 70.37±9.07, 52.64±8.28 and 34.21±6.63%, respectively. For the in vivo experiments, optical imaging indicated significantly decreased optical signals in the combination therapy group, as compared with the gemcitabine and gemcitabine + gene groups (1.68±0.74 vs. 2.27±0.58 and 2.87±0.82, respectively; Р<0.05). As demonstrated by ultrasound imaging, reduced tumor volumes were detected in the combination therapy group, as compared with the three control groups (114.32±17.17 vs. 159±23.74, 201.63±19.26 and 298.23±36.1 mm3, respectively; P<0.05). The results of the present study demonstrated that gemcitabine enhances the antitumoral effects of HSV-TK/GCV on cholangiocarcinoma, which may provide a novel therapeutic strategy for the management and treatment of cholangiocarcinoma using gemcitabine and gene therapy. PMID:27347037

  11. Electrodynamic Dust Shield Demonstrator

    NASA Technical Reports Server (NTRS)

    Stankie, Charles G.

    2013-01-01

    The objective of the project was to design and manufacture a device to demonstrate a new technology developed by NASA's Electrostatics and Surface Physics Laboratory. The technology itself is a system which uses magnetic principles to remove regolith dust from its surface. This project was to create an enclosure that will be used to demonstrate the effectiveness of the invention to The Office of the Chief Technologist. ONE of the most important challenges of space exploration is actually caused by something very small and seemingly insignificant. Dust in space, most notably on the moon and Mars, has caused many unforeseen issues. Dirt and dust on Earth, while a nuisance, can be easily cleaned and kept at bay. However, there is considerably less weathering and erosion in space. As a result, the microscopic particles are extremely rough and abrasive. They are also electrostatically charged, so they cling to everything they make contact with. This was first noted to be a major problem during the Apollo missions. Dust would stick to the spacesuits, and could not be wiped off as predicted. Dust was brought back into the spacecraft, and was even inhaled by astronauts. This is a major health hazard. Atmospheric storms and other events can also cause dust to coat surfaces of spacecraft. This can cause abrasive damage to the craft. The coating can also reduce the effectiveness of thermal insulation and solar panels.' A group of engineers at Kennedy Space Center's Electrostatics and Surface Physics Laboratory have developed a new technology, called the Electrodynamic Dust Shield, to help alleviate these problems. It is based off of the electric curtain concept developed at NASA in 1967. "The EDS is an active dust mitigation technology that uses traveling electric fields to transport electrostatically charged dust particles along surfaces. To generate the traveling electric fields, the EDS consists of a multilayer dielectric coating with an embedded thin electrode grid

  12. Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats.

    PubMed

    Yogalakshmi, Baskaran; Viswanathan, Periyasamy; Anuradha, Carani Venkatraman

    2010-02-01

    The present study investigated the preventive effect of eugenol, a naturally occurring food flavouring agent on thioacetamide (TA)-induced hepatic injury in rats. Adult male Wistar rats of body weight 150-180 g were used for the study. Eugenol (10.7 mg/kg b.w./day) was administered to rats by oral intubation for 15 days. TA was administered (300 mg/kg b.w., i.p.) for the last 2 days at 24h interval and the rats were sacrificed on the 16th day. Markers of liver injury (aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma-glutamyl transferase and bilirubin), inflammation (myeloperoxidase, tumor necrosis factor-alpha and interleukin-6), oxidative stress (lipid peroxidation indices, protein carbonyl and antioxidant status) and cytochrome P4502E1 activity were assessed. Expression of cyclooxygenase-2 (COX-2) and the extent of DNA damage were analyzed using immunoblotting and comet assay, respectively. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin and Masson trichrome staining. Rats exposed to TA alone showed increased activities of hepatocellular enzymes in plasma, lipid peroxidation indices, inflammatory markers and pro-inflammatory cytokines and decreased antioxidant status in circulation and liver. Hepatic injury and necrosis were also evidenced by histology. Eugenol pretreatment prevented liver injury by decreasing CYP2E1 activity, lipid peroxidation indices, protein oxidation and inflammatory markers and by improving the antioxidant status. Single-cell gel electrophoresis revealed that eugenol pretreatment prevented DNA strand break induced by TA. Increased expression of COX-2 gene induced by TA was also abolished by eugenol. These findings suggest that eugenol curtails the toxic effects of TA in liver. PMID:20036707

  13. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris, Ed.

    1987-01-01

    Describes several chemistry demonstrations that use an overhead projector. Some of the demonstrations deal with electrochemistry, and another deals with the reactions of nonvolatile immiscible liquid in water. (TW)

  14. Smart Grid Demonstration Project

    SciTech Connect

    Miller, Craig; Carroll, Paul; Bell, Abigail

    2015-03-11

    The National Rural Electric Cooperative Association (NRECA) organized the NRECA-U.S. Department of Energy (DOE) Smart Grid Demonstration Project (DE-OE0000222) to install and study a broad range of advanced smart grid technologies in a demonstration that spanned 23 electric cooperatives in 12 states. More than 205,444 pieces of electronic equipment and more than 100,000 minor items (bracket, labels, mounting hardware, fiber optic cable, etc.) were installed to upgrade and enhance the efficiency, reliability, and resiliency of the power networks at the participating co-ops. The objective of this project was to build a path for other electric utilities, and particularly electrical cooperatives, to adopt emerging smart grid technology when it can improve utility operations, thus advancing the co-ops’ familiarity and comfort with such technology. Specifically, the project executed multiple subprojects employing a range of emerging smart grid technologies to test their cost-effectiveness and, where the technology demonstrated value, provided case studies that will enable other electric utilities—particularly electric cooperatives— to use these technologies. NRECA structured the project according to the following three areas: Demonstration of smart grid technology; Advancement of standards to enable the interoperability of components; and Improvement of grid cyber security. We termed these three areas Technology Deployment Study, Interoperability, and Cyber Security. Although the deployment of technology and studying the demonstration projects at coops accounted for the largest portion of the project budget by far, we see our accomplishments in each of the areas as critical to advancing the smart grid. All project deliverables have been published. Technology Deployment Study: The deliverable was a set of 11 single-topic technical reports in areas related to the listed technologies. Each of these reports has already been submitted to DOE, distributed to co-ops, and

  15. Classical Demonstration of Polarization.

    ERIC Educational Resources Information Center

    Bauman, Robert P.; Moore, Dennis R.

    1980-01-01

    Presents a classical demonstration of polarization for high school students. The initial state of this model, which demonstrates the important concepts of the optical and quantum problems, was developed during the 1973 summer program on lecture demonstration at the U.S. Naval Academy. (HM)

  16. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris, Ed.

    1988-01-01

    Details two demonstrations for use with an overhead projector in a chemistry lecture. Includes "A Very Rapidly Growing Silicate Crystal" and "A Colorful Demonstration to Simulate Orbital Hybridization." The materials and directions for each demonstration are included as well as a brief explanation of the essential learning involved. (CW)

  17. ARJIS satellite demonstration project

    NASA Astrophysics Data System (ADS)

    Severance, Steve; Williams, Carl

    2005-06-01

    In 2003, the California Space Authority (CSA) was provided funding by the U. S. Congress through the Defense Appropriations Act to develop a project that would demonstrate the U.S. space enterprise capability that would contribute to the effectiveness of those engaged in Homeland Security. The project was given broad latitude in selecting the area of Homeland Security to be addressed and the nature of the space technology to be applied. CSA became aware of a nascent law enforcement data-sharing project in the San Diego region known as the Automated Regional Justice Information System (ARJIS). First developed by the police departments in San Diego, ARJIS is an innovative system that shares criminal justice information among 50 federal, state, and local agencies. ARJIS was completing a pilot project that enabled officers to receive information on handheld computers, which was transmitted wirelessly through cellular networks. The accessed information came from several databases that collectively contained the entire region's crime and arrest reports, traffic citations, and incidents, as well as state and county wants and warrants. The fundamental limitations that plague all cellular-based devices caught CSA's attention and resulted in a cooperative effort to harden the communications link between the patrol officer and critical data. The principal goal of the SATCOM development task was to create a proof-of-concept application that would use SATCOM links to augment the current ARJIS handheld wireless (cellular) capability. The successful technical demonstration and the positive support for satellite communications from the law enforcement community showed that this project filled a need-both for improved information sharing and for highly reliable communications systems.

  18. Pacific Northwest Resources Inventory Demonstration

    NASA Technical Reports Server (NTRS)

    Nichols, J. D.

    1976-01-01

    The Pacific Northwest Land Resource Inventory Demonstration project is designed to demonstrate to users from state and local agencies in Washington, Oregon, and Idaho the cost effective role that Landsat derived information can play in natural resource planning and management when properly supported by ground and aircraft data. The project has been organized into five main phases: (1) maps and overlays, (2) early digital image analysis, (3) demonstration of applications using interactive image analysis, (4) Landsat products and land resources information systems, and (5) documentation. The demonstration project has been applied to Washington forestry, water inventory in southern Idaho, and monitoring of tansy ragwort in western Oregon.

  19. Strategy Guideline: Demonstration Home

    SciTech Connect

    Savage, C.; Hunt, A.

    2012-12-01

    This guideline will provide a general overview of the different kinds of demonstration home projects, a basic understanding of the different roles and responsibilities involved in the successful completion of a demonstration home, and an introduction into some of the lessons learned from actual demonstration home projects. Also, this guideline will specifically look at the communication methods employed during demonstration home projects. And lastly, we will focus on how to best create a communication plan for including an energy efficient message in a demonstration home project and carry that message to successful completion.

  20. Strategy Guideline. Demonstration Home

    SciTech Connect

    Hunt, A.; Savage, C.

    2012-12-01

    This guideline will provide a general overview of the different kinds of demonstration home projects, a basic understanding of the different roles and responsibilities involved in the successful completion of a demonstration home, and an introduction into some of the lessons learned from actual demonstration home projects. Also, this guideline will specifically look at the communication methods employed during demonstration home projects. And lastly, we will focus on how to best create a communication plan for including an energy efficient message in a demonstration home project and carry that message to successful completion.

  1. Data surety demonstrations

    SciTech Connect

    Draelos, T.; Harris, M.; Herrington, P.; Kromer, D.

    1998-08-01

    The use of data surety within the International Monitoring System (IMS) is designed to offer increased trust of acquired sensor data at a low cost. The demonstrations discussed in the paper illustrate the feasibility of hardware authentication for sensor data and commands in a retrofit environment and a new system and of the supporting key management system. The individual demonstrations which are summarized in the paper are: (1) demonstration of hardware authentication for communication authentication in a retrofit environment; (2)demonstration of hardware authentication in a new system; and (3) demonstration of key management for sensor data and command authentication.

  2. Nursing Management Minimum Data Set: Cost-Effective Tool To Demonstrate the Value of Nurse Staffing in the Big Data Science Era.

    PubMed

    Pruinelli, Lisiane; Delaney, Connie W; Garciannie, Amy; Caspers, Barbara; Westra, Bonnie L

    2016-01-01

    There is a growing body of evidence of the relationship of nurse staffing to patient, nurse, and financial outcomes. With the advent of big data science and developing big data analytics in nursing, data science with the reuse of big data is emerging as a timely and cost-effective approach to demonstrate nursing value. The Nursing Management Minimum Date Set (NMMDS) provides standard administrative data elements, definitions, and codes to measure the context where care is delivered and, consequently, the value of nursing. The integration of the NMMDS elements in the current health system provides evidence for nursing leaders to measure and manage decisions, leading to better patient, staffing, and financial outcomes. It also enables the reuse of data for clinical scholarship and research. PMID:27265947

  3. The social effects of poor classroom acoustics on students and The District of Columbia Public Schools demonstration of support through mandating the ANSI Classroom Acoustics standard

    NASA Astrophysics Data System (ADS)

    Ellis, Donna

    2002-11-01

    The effects that poor acoustics have on students extend beyond the classroom. This paper is to discuss the immediate and long-term results that inadequate acoustical design in the educational setting has on academic and social development and how the District of Columbia Public Schools (DCPS) are contributing to the classroom acoustic movement. DCPS is taking a pro-active stance in educational acoustics by mandating the ANSI Draft S12.60-200X classroom acoustic standard in the transformation of ten schools a year for the next ten to fifteen years. Synthesizing the ANSI S12 standard with the DCPS Design Guidelines describes explanation of how to design for appropriate acoustics in all core-learning spaces. Examples of the existing conditions of the facilities and acoustical remediation for new and historical preservation projects will be demonstrated. In addition, experience will be shared on the International Building Code Council hearings for classroom acoustics.

  4. Tidd PFBC demonstration project

    SciTech Connect

    Marrocco, M.

    1997-12-31

    The Tidd project was one of the first joint government-industry ventures to be approved by the US Department of Energy (DOE) in its Clean Coal Technology Program. In March 1987, DOE signed an agreement with the Ohio Power Company, a subsidiary of American Electric Power, to refurbish the then-idle Tidd plant on the banks of the Ohio River with advanced pressurized fluidized bed technology. Testing ended after 49 months of operation, 100 individual tests, and the generation of more than 500,000 megawatt-hours of electricity. The demonstration plant has met its objectives. The project showed that more than 95 percent of sulfur dioxide pollutants could be removed inside the advanced boiler using the advanced combustion technology, giving future power plants an attractive alternative to expensive, add-on scrubber technology. In addition to its sulfur removal effectiveness, the plant`s sustained periods of steady-state operation boosted its availability significantly above design projections, heightening confidence that pressurized fluidized bed technology will be a reliable, baseload technology for future power plants. The technology also controlled the release of nitrogen oxides to levels well below the allowable limits set by federal air quality standards. It also produced a dry waste product that is much easier to handle than wastes from conventional power plants and will likely have commercial value when produced by future power plants.

  5. Exploration Technology Development & Demonstration

    NASA Video Gallery

    Chris Moore delivers a presentation from the Exploration Technology Development & Demonstration (ETDD) study team on May 25, 2010, at the NASA Exploration Enterprise Workshop held in Galveston, TX....

  6. LIMB demonstration project extension

    SciTech Connect

    Not Available

    1990-09-21

    The purpose of the DOE limestone injection multistage burner (LIMB) Demonstration Project Extension is to extend the data base on LIMB technology and to expand DOE's list of Clean Coal Technologies by demonstrating the Coolside process as part of the project. The main objectives of this project are: to demonstrate the general applicability of LIMB technology by testing 3 coals and 4 sorbents (total of 12 coal/sorbent combinations) at the Ohio Edison Edgewater plant; and to demonstrate that Coolside is a viable technology for improving precipitator performance and reducing sulfur dioxide emissions while acceptable operability is maintained. Progress is reported. 3 figs.

  7. NESC VII European project: demonstration of warm pre-stressing effect in biaxial loading conditions - Bending tests on 18MND5 cruciform specimens and their interpretation

    SciTech Connect

    Jacquemoud, C.; Yuritzinn, T.; Marie, S.

    2012-07-01

    In the framework of the NESC VII European project, a large experimental program has been dedicated to characterize the Warm Pre-Stressing (WPS) effect in different testing configurations. One of the CEA (France) contributions to this project is the realization of five point bending tests on large cruciform specimens considering different WPS loading cycles. The five cruciform specimens, sponsored by EDF (France) and IRSN (France), are made of 18MND5 steel. Two of them have been tested on a same LCF (Load-Cool-Fracture) loading cycle and two others on the same LCTF (Load-Cool-Transient-Fracture) loading cycle. The experimental results presented in this paper give a successful demonstration of the WPS effect in biaxial loading conditions either on a LCF or on a LCTF cycle. During the test interpretations, different models have then been tested and compared in order to evaluate their ability to predict the cleavage fracture in the case of different WPS loading cycles. They all provide very conservative predictions whatever loading cycle is concerned. (authors)

  8. The Microgravity Demonstrator.

    ERIC Educational Resources Information Center

    Rogers, Melissa J. B.; Wargo, Michael J.

    The Microgravity Demonstrator is a tool used to create microgravity conditions in the classroom. A series of demonstrations is used to provide a dramatically visual, physical connection between free-fall and microgravity conditions in order to understand why various types of experiments are performed under microgravity conditions. The manual is…

  9. Demonstrating Newton's Second Law.

    ERIC Educational Resources Information Center

    Fricker, H. S.

    1994-01-01

    Describes an apparatus for demonstrating the second law of motion. Provides sample data and discusses the merits of this method over traditional methods of supplying a constant force. The method produces empirical best-fit lines which convincingly demonstrate that for a fixed mass, acceleration is proportional to force. (DDR)

  10. Better Ira Remsen Demonstration

    ERIC Educational Resources Information Center

    Dalby, David K.; Maynard, James H.; Moore, John W.

    2011-01-01

    Many versions of the classic Ira Remsen experience involving copper and concentrated nitric acid have been used as lecture demonstrations. Remsen's original reminiscence from 150 years ago is included in the Supporting Information, and his biography can be found on the Internet. This article presents a new version that makes the demonstration more…

  11. Kinetics and Catalysis Demonstrations.

    ERIC Educational Resources Information Center

    Falconer, John L.; Britten, Jerald A.

    1984-01-01

    Eleven videotaped kinetics and catalysis demonstrations are described. Demonstrations include the clock reaction, oscillating reaction, hydrogen oxidation in air, hydrogen-oxygen explosion, acid-base properties of solids, high- and low-temperature zeolite reactivity, copper catalysis of ammonia oxidation and sodium peroxide decomposition, ammonia…

  12. A Stellar Demonstrator

    ERIC Educational Resources Information Center

    Ros, Rosa M.

    2009-01-01

    The main purpose of the stellar demonstrator is to help explain the movement of stars. In particular, students have difficulties understanding why, if they are living in the Northern Hemisphere, they may observe starts in the Southern Hemisphere, or why circumpolar stars are not the same in different parts of Europe. Using the demonstrator, these…

  13. A Greener Chemiluminescence Demonstration

    ERIC Educational Resources Information Center

    Jilani, Osman; Donahue, Trisha M.; Mitchell, Miguel O.

    2011-01-01

    Because they are dramatic and intriguing, chemiluminescence demonstrations have been used for decades to stimulate interest in chemistry. One of the most intense chemiluminescent reactions is the oxidation of diaryl oxalate diesters with hydrogen peroxide in the presence of a fluorescer. In typical lecture demonstrations, the commercially…

  14. Demonstrating Phase Changes.

    ERIC Educational Resources Information Center

    Rohr, Walter

    1995-01-01

    Presents two experiments that demonstrate phase changes. The first experiment explores phase changes of carbon dioxide using powdered dry ice sealed in a piece of clear plastic tubing. The second experiment demonstrates an equilibrium process in which a crystal grows in equilibrium with its saturated solution. (PVD)

  15. USFWS demonstration fees

    USGS Publications Warehouse

    Taylor, Jonathan; Vaske, Jerry; Donnelly, Maureen; Shelby, Lori

    2002-01-01

    This study examined National Wildlife Refuge (NWR) visitors' reactions to changes in fees implemented as part of the fee demonstration program. Visitors' evaluations of the fees paid were examined in addition to their beliefs about fees and the fee demonstration program, and the impact of fees paid on their intention to return. All results were analyzed relative to socio-demographic characteristics.

  16. Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams.

    PubMed

    Kano, M; Matsushita, K; Rahmutulla, B; Yamada, S; Shimada, H; Kubo, S; Hiwasa, T; Matsubara, H; Nomura, F

    2016-01-01

    Combination therapy of carbon-ion beam with the far upstream element-binding protein (FBP)-interacting repressor, FIR, which interferes with DNA damage repair proteins, was proposed as an approach for esophageal cancer treatment with low side effects regardless of TP53 status. In vivo therapeutic antitumor efficacy of replication-defective adenovirus (E1 and E3 deleted adenovirus serotype 5) encoding human FIR cDNA (Ad-FIR) was demonstrated in the tumor xenograft model of human esophageal squamous cancer cells, TE-2. Bleomycin (BLM) is an anticancer agent that introduces DNA breaks. The authors reported that Ad-FIR involved in the BLM-induced DNA damage repair response and thus applicable for other DNA damaging agents. To examine the effect of Ad-FIR on DNA damage repair, BLM, X-ray and carbon-ion irradiation were used as DNA damaging agents. The biological effects of high linear energy transfer (LET) radiotherapy used with carbon-ion irradiation are more expansive than low-LET conventional radiotherapy, such as X-rays or γ rays. High LET radiotherapy is suitable for the local control of tumors because of its high relative biological effectiveness. Ad-FIR enhanced BLM-induced DNA damage indicated by γH2AX in vitro. BLM treatment increased endogenous nuclear FIR expression in TE-2 cells, and P27Kip1 expression was suppressed by TP53 siRNA and BLM treatment. Further, Ad-FIRΔexon2, a dominant-negative form of FIR that lacks exon2 transcriptional repression domain, decreased Ku86 expression. The combination of Ad-FIR and BLM in TP53 siRNA increased DNA damage. Additionally, Ad-FIR showed synergistic cell toxicity with X-ray in vitro and significantly increased the antitumor efficacy of carbon-ion irradiation in the xenograft mouse model of TE-2 cells (P=0.03, Mann-Whitney's U-test) and was synergistic with the sensitization enhancement ratio (SER) value of 1.15. Therefore, Ad-FIR increased the cell-killing activity of the carbon-ion beam that avoids late

  17. Demonstrating environmental compliance

    SciTech Connect

    Pankratz, R.H.

    1995-12-31

    Almost every company, plant, or government entity wants to be in compliance with environmental statutes, regulations, and permit provisions. Today wanting is not enough. At the Pantex Plant, we have taken the approach, that unless we can demonstrate compliance, we are not necessarily in compliance. This paper is intended to illustrate how the Pantex Plant has designed its various programs to demonstrate compliance with environmental statutes, regulations, and permit provisions. A major emphasis is to have permit provisions that are objective and measurable so as to aid in demonstrating compliance. In conjunction with unambiguous permit provisions, appropriate management systems are required to provide the necessary records for this documentation.

  18. Demonstrating Natural Selection

    ERIC Educational Resources Information Center

    Hinds, David S.; Amundson, John C.

    1975-01-01

    Describes laboratory exercises with chickens selecting their food from dyed and natural corn kernels as a method of demonstrating natural selection. The procedure is based on the fact that organisms that blend into their surroundings escape predation. (BR)

  19. Remote Agent Demonstration

    NASA Technical Reports Server (NTRS)

    Dorais, Gregory A.; Kurien, James; Rajan, Kanna

    1999-01-01

    We describe the computer demonstration of the Remote Agent Experiment (RAX). The Remote Agent is a high-level, model-based, autonomous control agent being validated on the NASA Deep Space 1 spacecraft.

  20. Methanol Cannon Demonstrations Revisited.

    ERIC Educational Resources Information Center

    Dolson, David A.; And Others

    1995-01-01

    Describes two variations on the traditional methanol cannon demonstration. The first variation is a chain reaction using real metal chains. The second example involves using easily available components to produce sequential explosions that can be musical in nature. (AIM)

  1. Commissioning the Majorana Demonstrator

    NASA Astrophysics Data System (ADS)

    Xu, Wenqin; Majorana Collaboration

    2016-03-01

    The Majorana Demonstrator deploys high purity germanium (HPGe) detector modules to search for neutrinoless double beta (0 νββ) decay in 76Ge. The experiment is aimed at demonstrating the technical feasibility and low backgrounds for a next generation Ge-based BBz experiment. The program of testing and commissioning the Demonstrator modules is a critical step to debug and improve the experimental apparatus, to establish and refine operational procedures, and to develop data analysis tools. In this talk, we will discuss our experience commissioning the Demonstrator modules and show how this program leads to successful data-taking. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, the Particle Astrophysics and Nuclear Physics Programs of the National Science Foundation, and the Sanford Underground Research Facility.

  2. Spacecraft servicing demonstration plan

    NASA Technical Reports Server (NTRS)

    Bergonz, F. H.; Bulboaca, M. A.; Derocher, W. L., Jr.

    1984-01-01

    A preliminary spacecraft servicing demonstration plan is prepared which leads to a fully verified operational on-orbit servicing system based on the module exchange, refueling, and resupply technologies. The resulting system can be applied at the space station, in low Earth orbit with an orbital maneuvering vehicle (OMV), or be carried with an OMV to geosynchronous orbit by an orbital transfer vehicle. The three phase plan includes ground demonstrations, cargo bay demonstrations, and free flight verifications. The plan emphasizes the exchange of multimission modular spacecraft (MMS) modules which involves space repairable satellites. Three servicer mechanism configurations are the engineering test unit, a protoflight quality unit, and two fully operational units that have been qualified and documented for use in free flight verification activity. The plan balances costs and risks by overlapping study phases, utilizing existing equipment for ground demonstrations, maximizing use of existing MMS equipment, and rental of a spacecraft bus.

  3. EVA Retriever Demonstration

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The EVA retriever is demonstrated in the Manipulator Development Facility (MDF). The retriever moves on the air bearing table 'searching' for its target, in this case tools 'dropped' by astronauts on orbit.

  4. Technology Demonstration Missions

    NASA Video Gallery

    NASA's Technology Demonstration Missions (TDM) Program seeks to infuse new technology into space applications, bridging the gap between mature “lab-proven” technology and "flight-ready" status....

  5. Flagship Technology Demonstrations (FTD)

    NASA Video Gallery

    Mike Conley delivers a presentation from the Flagship Technology Demonstrations (FTD) study team on May 25, 2010, at the NASA Exploration Enterprise Workshop held in Galveston, TX. The purpose of t...

  6. Demonstration of Surface Tension.

    ERIC Educational Resources Information Center

    Rosenthal, Andrew J.

    2001-01-01

    Surface tension is a fundamental obstacle in the spontaneous formation of bubbles, droplets, and crystal nuclei in liquids. Describes a simple overhead projector demonstration that illustrates the power of surface tension that can prevent so many industrial processes. (ASK)

  7. Five amazing physics demonstrations

    NASA Astrophysics Data System (ADS)

    Downie, Neil

    2015-04-01

    There's nothing better than a good physics demonstration to illustrate the subject's fundamental principles. Neil Downie, who has run Saturday science clubs for children for more than two decades, presents his five best demos of all time.

  8. Classroom Demonstration of Sunspots.

    ERIC Educational Resources Information Center

    Callaway, Thomas O.; And Others

    1982-01-01

    An overhead projector, projection screen, and clear tungsten Filament light bulb operated through a dimmer or variac switch are used to demonstrate the fact that black appearance of sunspots is due only to contrast and that sunspots are bright. (SK)

  9. Education Payload Operation - Demonstrations

    NASA Technical Reports Server (NTRS)

    Keil, Matthew

    2009-01-01

    Education Payload Operation - Demonstrations (EPO-Demos) are recorded video education demonstrations performed on the International Space Station (ISS) by crewmembers using hardware already onboard the ISS. EPO-Demos are videotaped, edited, and used to enhance existing NASA education resources and programs for educators and students in grades K-12. EPO-Demos are designed to support the NASA mission to inspire the next generation of explorers.

  10. Dexterous manipulator flight demonstration

    NASA Technical Reports Server (NTRS)

    Carter, Edward L.

    1989-01-01

    The Dexterous Manipulator Flight Experiment, an outgrowth of the Dexterous End Effector project, is an experiment to demonstrate newly developed equipment and methods that make for a dexterous manipulator which can be used on the Space Shuttle or other space missions. The goals of the project, the objectives of the flight experiment, the experiment equipment, and the tasks to be performed during the demonstration are discussed.

  11. Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solutions Demonstrate Equal Effectiveness in Preventing Cellular Edema in Preserved Human Pancreata Intended for Islet Isolation

    PubMed Central

    Pauster, Daniel; Qi, Meirigeng; Danielson, Kirstie K.; Harvat, Tricia A.; Kinzer, Katie; Barbaro, Barbara; Patel, Sonny; Hassan, Sarah Z.; Oberholzer, Jose; Wang, Yong

    2013-01-01

    We have previously reported that both Histidine-Tryptophan-Ketoglutarate solution (HTK) and University of Wisconsin solution (UW) provide equal preservation of the pancreas for islet isolation, based upon the assessment of islet yield and function. In this study, we further assessed the ability of each solution to prevent cellular edema. This large-scale, retrospective analysis included the assessment of islet isolation outcomes influenced by cellular edema, such as pancreatic digestion efficacy, purification outcome, and islet size distribution. Multi-variable linear regression analysis, adjusted for donor age, sex, BMI, cold ischemia time, and enzyme, demonstrated similar results for the HTK group (n = 95) and the UW group (n = 157), including post-purification islet yields (the HTK: 289,702 vs. the UW: 283,036; p = 0.76), percentage of digested pancreatic tissue (the HTK: 66.9% vs. the UW: 64.1%; p = 0.18), and islet loss from post-digestion to post-purification (the HTK: 24,972 vs. the UW: 39,551; p = 0.38). Changes in islet size between the post-digestion and post-purification stages were comparable within each islet size category for the HTK and the UW groups (p = 0.14 - 0.99). Tissue volume distribution across purification fractions and islet purity in the top fractions were similar between the groups; however, the HTK group had significantly higher islet purity in the middle fractions (p = 0.003 - 0.008). Islet viability and stimulation indices were also similar between the HTK and the UW groups. In addition, we analyzed a small sample of patients transplanted either with HTK (n = 7) or UW (n = 8) preserved islets and found similar outcomes. This study demonstrates that HTK and UW solutions offer comparable pancreas preservation and are equally efficacious in the prevention of pancreatic tissue edema in islet transplantation. Future studies assessing in vivo islet outcomes in larger samples are needed for complete analysis of the effects of HTK on islet

  12. In vivo inhibition followed by exogenous supplementation demonstrates galactopoietic effects of prolactin on mammary tissue and milk production in dairy cows.

    PubMed

    Lollivier, V; Lacasse, P; Angulo Arizala, J; Lamberton, P; Wiart, S; Portanguen, J; Bruckmaier, R; Boutinaud, M

    2015-12-01

    It has been previously shown that the long-term inhibition of milking-induced prolactin (PRL) release by quinagolide (QN), a dopamine agonist, reduces milk yield in dairy cows. To further demonstrate that PRL is galactopoietic in cows, we performed a short-term experiment that used PRL injections to restore the release of PRL at milking in QN-treated cows. Nine Holstein cows were assigned to treatments during three 5-d periods in a 3×3 Latin square design: 1) QN: twice-daily i.m. injections of 1mg of QN; 2) QN-PRL: twice-daily i.m. injections of 1mg of QN and twice-daily (at milking time) i.v. injections of PRL (2µg/kg body weight); and 3) control: twice-daily injections of the vehicles. Mammary epithelial cells (MEC) were purified from milk so that their viability could be assessed, and mammary biopsies were harvested for immunohistological analyses of cell proliferation using PCNA and STAT5 staining. In both milk-purified MEC and mammary tissue, the mRNA levels of milk proteins and BAX were determined using real-time reverse-transcription PCR. Daily QN injections reduced milking-induced PRL release. The area under the PRL curve was similar in the control and PRL injection treatments, but the shape was different. The QN treatment decreased milk, lactose, protein, and casein production. Injections of PRL did not restore milk yield but tended to increase milk protein yield. In mammary tissue, the percentage of STAT5-positive cells was reduced during QN but not during QN-PRL in comparison with the control treatment. The percentage of PCNA-positive cells was greater during QN-PRL injections than during the control or QN treatment and tended to be lower during QN than during the control treatment. In milk-purified MEC, κ-casein and α-lactalbumin mRNA levels were lower during QN than during the control treatment, but during QN-PRL, they were not different from the control treatment. In mammary tissue, the BAX mRNA level was lower during QN-PRL than during QN. The

  13. Favorite Demonstrations: A Macroscopic Demonstration of a Microscopic Phenomenon.

    ERIC Educational Resources Information Center

    Mellen, John W.

    1988-01-01

    Finding ways to demonstrate microscopic phenomena and contending with life science students' lack of interest in physical principles are two problems in laboratory courses. Describes a clinical laboratory test for parasite infection that can be used to effectively solve both of them. (RT)

  14. Offsite demonstrations for MWLID technologies

    SciTech Connect

    Williams, C.; Gruebel, R.

    1995-04-01

    The goal of the Offsite Demonstration Project for Mixed Waste Landfill Integrated Demonstration (MWLID)-developed environmental site characterization and remediation technologies is to facilitate the transfer, use, and commercialization of these technologies to the public and private sector. The meet this goal, the project identified environmental restoration needs of mixed waste and/or hazardous waste landfill owners (Native American, municipal, DOE, and DoD); documenting potential demonstration sites and the contaminants present at each site; assessing the environmental regulations that would effect demonstration activities; and evaluating site suitability for demonstrating MWLID technologies at the tribal and municipal sites identified. Eighteen landfill sites within a 40.2-km radius of Sandia National Laboratories are listed on the CERCLIS Site/Event Listing for the state of New Mexico. Seventeen are not located within DOE or DoD facilities and are potential offsite MWLID technology demonstration sites. Two of the seventeen CERCLIS sites, one on Native American land and one on municipal land, were evaluated and identified as potential candidates for off-site demonstrations of MWLID-developed technologies. Contaminants potentially present on site include chromium waste, household/commercial hazardous waste, volatile organic compounds, and petroleum products. MWLID characterization technologies applicable to these sites include Magnetometer Towed Array, Cross-borehole Electromagnetic Imaging, SitePlanner {trademark}/PLUME, Hybrid Directional Drilling, Seamist{trademark}/Vadose Zone Monitoring, Stripping Analyses, and x-ray Fluorescence Spectroscopy for Heavy Metals.

  15. TRUEX hot demonstration

    SciTech Connect

    Chamberlain, D.B.; Leonard, R.A.; Hoh, J.C.; Gay, E.C.; Kalina, D.G.; Vandegrift, G.F.

    1990-04-01

    In FY 1987, a program was initiated to demonstrate technology for recovering transuranic (TRU) elements from defense wastes. This hot demonstration was to be carried out with solution from the dissolution of irradiated fuels. This recovery would be accomplished with both PUREX and TRUEX solvent extraction processes. Work planned for this program included preparation of a shielded-cell facility for the receipt and storage of spent fuel from commercial power reactors, dissolution of this fuel, operation of a PUREX process to produce specific feeds for the TRUEX process, operation of a TRUEX process to remove residual actinide elements from PUREX process raffinates, and processing and disposal of waste and product streams. This report documents the work completed in planning and starting up this program. It is meant to serve as a guide for anyone planning similar demonstrations of TRUEX or other solvent extraction processing in a shielded-cell facility.

  16. Autonomous docking ground demonstration

    NASA Technical Reports Server (NTRS)

    Lamkin, Steve L.; Le, Thomas Quan; Othon, L. T.; Prather, Joseph L.; Eick, Richard E.; Baxter, Jim M.; Boyd, M. G.; Clark, Fred D.; Spehar, Peter T.; Teters, Rebecca T.

    1991-01-01

    The Autonomous Docking Ground Demonstration is an evaluation of the laser sensor system to support the docking phase (12 ft to contact) when operated in conjunction with the guidance, navigation, and control (GN&C) software. The docking mechanism being used was developed for the Apollo/Soyuz Test Program. This demonstration will be conducted using the 6-DOF Dynamic Test System (DTS). The DTS simulates the Space Station Freedom as the stationary or target vehicle and the Orbiter as the active or chase vehicle. For this demonstration, the laser sensor will be mounted on the target vehicle and the retroflectors will be on the chase vehicle. This arrangement was chosen to prevent potential damage to the laser. The laser sensor system, GN&C, and 6-DOF DTS will be operated closed-loop. Initial conditions to simulate vehicle misalignments, translational and rotational, will be introduced within the constraints of the systems involved.

  17. Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

    PubMed Central

    Wan, Li; Zhang, Xiaoping; Gunaseelan, Simi; Pooyan, Shahriar; Debrah, Olivia; Leibowitz, Michael J; Rabson, Arnold B; Stein, Stanley; Sinko, Patrick J

    2006-01-01

    Background Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time. Despite this, curing AIDS remains an elusive goal, partially due to the occurrence of drug resistance. Since the development of resistance is linked to, among other things, fluctuating drug levels, our long-term goal has been to develop nanotechnology-based drug delivery systems that can improve therapy by more precisely controlling drug concentrations in target cells. The theme of the current study is to investigate the value of combining AIDS drugs and modifiers of cellular uptake into macromolecular conjugates having novel pharmacological properties. Results Bioconjugates were prepared from different combinations of the approved drug, saquinavir, the antiviral agent, R.I.CK-Tat9, the polymeric carrier, poly(ethylene) glycol and the cell uptake enhancer, biotin. Anti-HIV activities were measured in MT-2 cells, an HTLV-1-transformed human lymphoid cell line, infected with HIV-1 strain Vbu 3, while parallel studies were performed in uninfected cells to determine cellular toxicity. For example, R.I.CK-Tat9 was 60 times more potent than L-Tat9 while the addition of biotin resulted in a prodrug that was 2850 times more potent than L-Tat9. Flow cytometry and confocal microscopy studies suggest that variations in intracellular uptake and intracellular localization, as well as synergistic inhibitory effects of SQV and Tat peptides, contributed to the unexpected and substantial differences in antiviral activity. Conclusion Our results demonstrate that highly potent nanoscale multi-drug conjugates with low non-specific toxicity can be produced by combining moieties with anti-HIV agents for different targets onto macromolecules having improved delivery properties. PMID:16635263

  18. Gigashot Optical Laser Demonstrator

    SciTech Connect

    Deri, R. J.

    2015-10-13

    The Gigashot Optical Laser Demonstrator (GOLD) project has demonstrated a novel optical amplifier for high energy pulsed lasers operating at high repetition rates. The amplifier stores enough pump energy to support >10 J of laser output, and employs conduction cooling for thermal management to avoid the need for expensive and bulky high-pressure helium subsystems. A prototype amplifier was fabricated, pumped with diode light at 885 nm, and characterized. Experimental results show that the amplifier provides sufficient small-signal gain and sufficiently low wavefront and birefringence impairments to prove useful in laser systems, at repetition rates up to 60 Hz.

  19. Space fabrication demonstration system

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The lower right aluminum beam cap roll forming mill was delivered and installed in the beam builder. The beam was brought to full operational status and beams of one to six bay lengths were produced to demonstrate full system capability. Although the cap flange waviness problem persists, work is progressing within cost and schedule.

  20. A Biofeedback Demonstration.

    ERIC Educational Resources Information Center

    Garrity, Michael K.

    1978-01-01

    Describes a demonstration for measurement of biophysical signals produced by the human body. The signals, after amplification, could provide acoustical feedback through a voltage-controlled oscillator (VCO), or they could be seen either with an oscilloscope or a high speed chart recorder. (GA)

  1. Why Demonstrations Matter

    ERIC Educational Resources Information Center

    Black, Richard

    2005-01-01

    The author remembers how exciting it was when the teacher had "stuff" on the front desk: unfamiliar objects and other things out of place in the traditional classroom. Years later, as a new teacher, the author learned the importance of building lessons around concepts and that demonstrations are an integral part of concept development in science.…

  2. ALASKA VILLAGE DEMONSTRATION PROJECTS

    EPA Science Inventory

    Two demonstration projects were built as authorized by Section 113 of PL 92-500. Modular construction was used to provide central utility systems which included water supply, laundry, bathing, saunas, and wastewater treatment. Service to homes was by vehicular delivery. Fire dest...

  3. Demonstrating the Gas Laws.

    ERIC Educational Resources Information Center

    Holko, David A.

    1982-01-01

    Presents a complete computer program demonstrating the relationship between volume/pressure for Boyle's Law, volume/temperature for Charles' Law, and volume/moles of gas for Avagadro's Law. The programing reinforces students' application of gas laws and equates a simulated moving piston to theoretical values derived using the ideal gas law.…

  4. Musical acoustics demonstrations

    NASA Astrophysics Data System (ADS)

    Hoekje, P. L.

    2003-10-01

    The ASA Musical Acoustics Demonstrations website (trial version at http://www.bw.edu/~phoekje) includes sound files, video clips, program code listings, and other material for demonstrations related to musical acoustics. Many of the sound demonstrations may be experienced either as expositions, in which the phenomena are explained before they are presented, or as experiments, in which the explanation comes after listeners have had the opportunity to draw their own conclusions. Suggestions are provided for apparatus construction and classroom experiments, as well as for building simple musical instruments. Software is recommended if it is available free and compatible with multiple personal computer operating systems. For example, Audacity (http://audacity.sourceforce.net) is a sound file editor and analyzer that can be used to visually represent sounds and manipulate them. Source files are included for the synthesized sound examples, which were created in Csound (http://csounds.com), so that interested users may create their own variations. Source code is also included for visual demonstrations created in Visual Python and Python (http://www.python.org), an efficient, high level programming language. Suggestions, criticisms, and contributions are always welcome! [Work supported by ASA and Baldwin-Wallace College.

  5. Polarized Light: Three Demonstrations.

    ERIC Educational Resources Information Center

    Goehmann, Ruth; Welty, Scott

    1984-01-01

    Describes three demonstrations used in the Chicago Museum of Science and Industry polarized light show. The procedures employed are suitable for the classroom by using smaller polarizers and an overhead projector. Topic areas include properties of cellophane tape, nondisappearing arrows, and rope through a picket fence. (JN)

  6. SOIL BIOVENTING DEMONSTRATION PROJECT

    EPA Science Inventory

    A pilot scale demonstration project of a soil bioventing system, which utilizes the biodegradation in soil and physical removal of VOC by induced air flow, is in operation at the U.S. Coast Guard Aviation Field in Traverse City, Michigan. he system is being tested to determine it...

  7. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris, Ed.

    1988-01-01

    Provides two demonstrations: (1) electrolyte migration of ions using colored ions which cross a strip of gelatin allowing for noticeable migration; and (2) photochemical reduction of Fe+3 by the citrate ion. Points out both reactions can be done in a Petri dish using common lab materials. (MVL)

  8. Astronomy Demonstrations and Models.

    ERIC Educational Resources Information Center

    Eckroth, Charles A.

    Demonstrations in astronomy classes seem to be more necessary than in physics classes for three reasons. First, many of the events are very large scale and impossibly remote from human senses. Secondly, while physics courses use discussions of one- and two-dimensional motion, three-dimensional motion is the normal situation in astronomy; thus,…

  9. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris, Ed.

    1989-01-01

    Presents two demonstrations using the overhead projector: (1) describes how to build a projecting voltmeter and presents uses for the classroom; and (2) investigates the color of fluorescent solutions by studying the absorption and transmission of light through the solutions. (MVL)

  10. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris, Ed.

    1989-01-01

    Described are three chemistry demonstrations: (1) a simple qualitative technique for taste pattern recognition in structure-activity relationships; (2) a microscale study of gaseous diffusion using bleach, HCl, ammonia, and phenolphthalein; and (3) the rotation of polarized light by stereoisomers of limonene. (MVL)

  11. More Diamagnetism Demonstrations

    NASA Astrophysics Data System (ADS)

    Conery, Chris; Goodrich, L. F.; Stauffer, T. C.

    2003-02-01

    Inspired by, among others, Charles Sawicki's description of an inexpensive diamagnetic levitation apparatus, we built two such devices for classroom use and for educational outreach at the National Institute of Standards and Technology, Boulder, Colo. With a slightly different setup, the same demonstration can be done horizontally on an overhead projector.

  12. Calculus Demonstrations Using MATLAB

    ERIC Educational Resources Information Center

    Dunn, Peter K.; Harman, Chris

    2002-01-01

    The note discusses ways in which technology can be used in the calculus learning process. In particular, five MATLAB programs are detailed for use by instructors or students that demonstrate important concepts in introductory calculus: Newton's method, differentiation and integration. Two of the programs are animated. The programs and the…

  13. A Fruity Biochemistry Demonstration

    ERIC Educational Resources Information Center

    Shmaefsky, Brian R.

    2005-01-01

    Classroom demonstrations are a great vehicle for getting students to apply information they have heard in a lecture. Educational research is replete with data showing that concept application in an inquiry setting reinforces long-term science content retention. This means that students learn best when they experience applications of concepts and…

  14. Demonstrating carbon capture

    SciTech Connect

    Qader, A.; Hooper, B.; Stevens, G.

    2009-11-15

    Australia is at the forefront of advancing CCS technology. The CO2CRC's H3 (Post-combustion) and Mulgrave (pre-combustion) capture projects are outlined. The capture technologies for these 2 demonstration projects are described. 1 map., 2 photos.

  15. Organic Lecture Demonstrations.

    ERIC Educational Resources Information Center

    Silversmith, Ernest F.

    1988-01-01

    Provides a listing of 35 demonstrations designed to generate interest in organic chemistry and help put points across. Topics include opening lecture; molecular structure and properties; halogenation; nucleophilic substitution, alkenes and dienes, stereochemistry, spectroscopy, alcohols and phenols, aldehydes and ketones; carboxylic acids, amines,…

  16. Participatory Lecture Demonstrations.

    ERIC Educational Resources Information Center

    Battino, Rubin

    1979-01-01

    The use of participatory lecture demonstrations in the classroom is described. Examples are given for the following topics: chromatography, chemical kinetics, balancing equations, the gas laws, kinetic molecular theory, Henry's law of gas solubility, electronic energy levels in atoms, and translational, vibrational, and rotational energies of…

  17. RADON MITIGATION STUDIES: NASHVILLE DEMONSTRATION

    EPA Science Inventory

    The report gives results of an EPA radon mitigation demonstration project involving 14 houses in the Nashville, TN, area with indoor radon levels of 5.6-47.6 pCi/L, using a variety of techniques, designed to be the most cost effective methods possible to implement, and yet adequa...

  18. Wave rotor demonstrator engine assessment

    NASA Technical Reports Server (NTRS)

    Snyder, Philip H.

    1996-01-01

    The objective of the program was to determine a wave rotor demonstrator engine concept using the Allison 250 series engine. The results of the NASA LERC wave rotor effort were used as a basis for the wave rotor design. A wave rotor topped gas turbine engine was identified which incorporates five basic requirements of a successful demonstrator engine. Predicted performance maps of the wave rotor cycle were used along with maps of existing gas turbine hardware in a design point study. The effects of wave rotor topping on the engine cycle and the subsequent need to rematch compressor and turbine sections in the topped engine were addressed. Comparison of performance of the resulting engine is made on the basis of wave rotor topped engine versus an appropriate baseline engine using common shaft compressor hardware. The topped engine design clearly demonstrates an impressive improvement in shaft horsepower (+11.4%) and SFC (-22%). Off design part power engine performance for the wave rotor topped engine was similarly improved including that at engine idle conditions. Operation of the engine at off design was closely examined with wave rotor operation at less than design burner outlet temperatures and rotor speeds. Challenges identified in the development of a demonstrator engine are discussed. A preliminary design was made of the demonstrator engine including wave rotor to engine transition ducts. Program cost and schedule for a wave rotor demonstrator engine fabrication and test program were developed.

  19. Automatic lighting controls demonstration

    SciTech Connect

    Rubinstein, F.; Verderber, R.

    1990-03-01

    The purpose of this work was to demonstrate, in a real building situation, the energy and peak demand reduction capabilities of an electronically ballasted lighting control system that can utilize all types of control strategies to efficiently manage lighting. The project has demonstrated that a state-of-the-art electronically ballasted dimmable lighting system can reduce energy and lighting demand by as least 50% using various combinations of control strategies. By reducing light levels over circulation areas (tuning) and reducing after hours light levels to accommodate the less stringent lighting demands of the cleaning crew (scheduling), lighting energy consumption on weekdays was reduced an average of 54% relative to the initial condition. 10 refs., 14 figs., 3 tabs.

  20. AVNG system demonstration

    SciTech Connect

    Thron, Jonathan Louis; Mac Arthur, Duncan W; Kondratov, Sergey; Livke, Alexander; Razinkov, Sergey

    2010-01-01

    An attribute measurement system (AMS) measures a number of unclassified attributes of potentially classified material. By only displaying these unclassified results as red or green lights, the AMS protects potentially classified information while still generating confidence in the measurement result. The AVNG implementation that we describe is an AMS built by RFNC - VNIIEF in Sarov, Russia. To provide additional confidence, the AVNG was designed with two modes of operation. In the secure mode, potentially classified measurements can be made with only the simple red light/green light display. In the open mode, known unclassified material can be measured with complete display of the information collected from the radiation detectors. The AVNG demonstration, which occurred in Sarov, Russia in June 2009 for a joint US/Russian audience, included exercising both modes of AVNG operation using a number of multi-kg plutonium sources. In addition to describing the demonstration, we will show photographs and/or video taken of AVNG operation.

  1. Mars Umbilical Technology Demonstrator

    NASA Technical Reports Server (NTRS)

    Houshangi, Nasser

    2000-01-01

    The objective of this project is to develop a autonomous umbilical mating for the mars umbilical technology demonstrator. The Mars Umbilical Technology Demonstrator (MUTD) shall provide electrical power and fiber optic data cable connections between two simulated mars vehicles. The Omnibot is used to provide the mobile base for the system. The mate to umbilical plate is mounted on a three axis Cartesian table, which is installed on the Omnibot mobile base. The Omnibot is controlled in a teleoperated mode. The operator using the vision system will guide the Omnibot to get close to the mate to plate. The information received from four ultrasonic sensors is used to identify the position of mate to plate and mate the umbilical plates autonomously. A successful experimentation verifies the approach.

  2. Chemical Domino Demonstration

    NASA Astrophysics Data System (ADS)

    Alexander, M. Dale

    1998-04-01

    The Chemical Domino Demonstration is both educational and entertaining. It provides an excellent means for a review of chemical concepts at the conclusion of a general chemistry course. This demonstration consists of a number of different chemical reactions occurring in sequence in a Rube Goldberg-type apparatus. These reactions include the reduction of water by an active metal, the oxidation of a moderately active metal by an acid, reduction of metallic ions by a metal of greater activity, acid-base neutralization reactions in solution monitored with indicators, a gas-phase acid-base neutralization reaction, decomposition of a compound, precipitation of an insoluble salt, substitution reactions of coordination complexes, and pyrotechnic oxidation-reduction reactions including a hypergolic oxidation-reduction reaction, an intramolecular oxidation-reduction reaction, and the combustion of a flammable gas.

  3. Overhead Projector Demonstrations.

    ERIC Educational Resources Information Center

    Kolb, Doris

    1988-01-01

    Describes two oscillating reactions: the Briggs-Raucher reaction using H202, KIO3, malonic acid, and MnSO4 which changes from yellow to blue, and the Belousov-Zhabotinskii reaction uses NaBrO3, NaBr, malonic acid, and ferroin solution and changes from red to blue. Includes a third color demonstration on the six oxidation states of manganese. (MVL)

  4. Joined Beryllium Mirror Demonstrator

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip; Parsonage, Tom; Burdine, Robert (Technical Monitor)

    2001-01-01

    Fabrications of large Beryllium optical components are fundamentally limited by available facility capabilities. To overcome this limitation, NASA funded Brush Wellman Corp to study a Be joining process. Four 76 mm diameters samples and a 0.5 mm diameter Joined Beryllium Mirror Demonstrator (JBMD) were fabricated. This presentation will review the fabrication of these samples and summarize the results of their cryogenic testing at MSFCs XRCF.

  5. Lunar Water Resource Demonstration

    NASA Technical Reports Server (NTRS)

    Muscatello, Anthony C.

    2008-01-01

    In cooperation with the Canadian Space Agency, the Northern Centre for Advanced Technology, Inc., the Carnegie-Mellon University, JPL, and NEPTEC, NASA has undertaken the In-Situ Resource Utilization (ISRU) project called RESOLVE. This project is a ground demonstration of a system that would be sent to explore permanently shadowed polar lunar craters, drill into the regolith, determine what volatiles are present, and quantify them in addition to recovering oxygen by hydrogen reduction. The Lunar Prospector has determined these craters contain enhanced hydrogen concentrations averaging about 0.1%. If the hydrogen is in the form of water, the water concentration would be around 1%, which would translate into billions of tons of water on the Moon, a tremendous resource. The Lunar Water Resource Demonstration (LWRD) is a part of RESOLVE designed to capture lunar water and hydrogen and quantify them as a backup to gas chromatography analysis. This presentation will briefly review the design of LWRD and some of the results of testing the subsystem. RESOLVE is to be integrated with the Scarab rover from CMIJ and the whole system demonstrated on Mauna Kea on Hawaii in November 2008. The implications of lunar water for Mars exploration are two-fold: 1) RESOLVE and LWRD could be used in a similar fashion on Mars to locate and quantify water resources, and 2) electrolysis of lunar water could provide large amounts of liquid oxygen in LEO, leading to lower costs for travel to Mars, in addition to being very useful at lunar outposts.

  6. Performance Measurement to Demonstrate Value.

    PubMed

    Hyder, Joseph A; Hebl, James R

    2015-12-01

    Anesthesiologists are obligated to demonstrate the value of the care they provide. The Centers for Medicare and Medicaid Services has multiple performance-based payment programs to drive high-value care and motivate integrated care for surgical patients and hospitalized patients. These programs rely on diverse arrays of performance measures and complex reporting rules. Among all specialties, anesthesiology has tremendous potential to effect wide-ranging change on diverse measures. Performance measures deserve scrutiny by anesthesiologists as tools to improve care, the means by which payment is determined, and as a means to demonstrate the value of care to surgeons, hospitals, and patients. PMID:26610623

  7. TRW utility demonstration unit

    SciTech Connect

    Not Available

    1990-01-01

    The TRW Advanced Entrained Coal Combustor Demonstration Project consists of retrofitting Orange and Rockland (O R) Utility Corporation's Lovett Plant Unit No. 3 with four (4) slagging combustors which will allow the gas/oil unit to fire 2.5% sulfur coal. The slagging combustor process will provide NO{sub x} and SO{sub x} emissions that meet NSPS and New York State Environmental Standards. During this report period, activity continued to address the total program funding shortfall. Ideas and responsibilities for further evaluation have been put forward to reduce the shortfall. In addition, an effort aimed at gaining additional program sponsorships, was initiated.

  8. NAVAJO ELECTRIFICATION DEMONSTRATION PROJECT

    SciTech Connect

    Terry W. Battiest

    2008-06-11

    The Navajo Electrification Demonstration Project (NEDP) is a multi-year project which addresses the electricity needs of the unserved and underserved Navajo Nation, the largest American Indian tribe in the United States. The program serves to cumulatively provide off-grid electricty for families living away from the electricty infrastructure, line extensions for unserved families living nearby (less than 1/2 mile away from) the electricity, and, under the current project called NEDP-4, the construction of a substation to increase the capacity and improve the quality of service into the central core region of the Navajo Nation.

  9. Santa Clara Demonstration Status

    SciTech Connect

    Leo, Anthony J.; Skok, Andrew J.; O'Shea, Thomas P.

    1996-08-01

    Fuel Cell Engineering Corporation (FCE) is in the fourth year of a DOE Cooperative Agreement Program (private-sector cost-shared) aimed at the demonstration of ERC's direct carbonate fuel cell (DFC) technology at full scale. FCE is a wholly owned subsidiary of Energy Research Corporation (ERC), which has been pursuing the development of the DFC for commercialization near the end of this decade. The DFC produces power directly from hydrocarbon fuels electrochemically, without the need for external reforming or intermediate mechanical conversion steps. As a result, the DFC has the potential to achieve very high efficiency with very low levels of environmental emissions. Modular DFC power plants, which can be shop-fabricated and sited near the user, are ideally suited for distributed generation, cogeneration, industrial, and defense applications. This project is an integral part of the ERC effort to commercialize the technology to serve these applications. Potential users of the commercial DFC power plant under development at ERC will require that the technology be demonstrated at or near the full scale of the commercial products. The objective of the Santa Clara Demonstration Project (SCDP) is to provide the first such demonstration of the technology. The approach ERC has taken in the commercialization of the DFC is described in detail elsewhere [1]. Briefly, an aggressive core technology development program is in place which is focused by ongoing contact with customers and vendors to optimize the design of the commercial power plant. ERC has selected a 2.85 MW power plant unit for initial market entry. Two ERC subsidiaries are supporting the commercialization effort: The Fuel Cell Manufacturing Corporation (FCMC) and the Fuel Cell Engineering Corporation (FCE). FCMC manufactures carbonate stacks and multi-stack modules, currently from its manufacturing facility in Torrington, CT. FCE is responsible for power plant design, integration of all subsystems, sales

  10. Exploration Medical System Demonstration

    NASA Technical Reports Server (NTRS)

    Rubin, D. A.; Watkins, S. D.

    2014-01-01

    BACKGROUND: Exploration class missions will present significant new challenges and hazards to the health of the astronauts. Regardless of the intended destination, beyond low Earth orbit a greater degree of crew autonomy will be required to diagnose medical conditions, develop treatment plans, and implement procedures due to limited communications with ground-based personnel. SCOPE: The Exploration Medical System Demonstration (EMSD) project will act as a test bed on the International Space Station (ISS) to demonstrate to crew and ground personnel that an end-to-end medical system can assist clinician and non-clinician crew members in optimizing medical care delivery and data management during an exploration mission. Challenges facing exploration mission medical care include limited resources, inability to evacuate to Earth during many mission phases, and potential rendering of medical care by non-clinicians. This system demonstrates the integration of medical devices and informatics tools for managing evidence and decision making and can be designed to assist crewmembers in nominal, non-emergent situations and in emergent situations when they may be suffering from performance decrements due to environmental, physiological or other factors. PROJECT OBJECTIVES: The objectives of the EMSD project are to: a. Reduce or eliminate the time required of an on-orbit crew and ground personnel to access, transfer, and manipulate medical data. b. Demonstrate that the on-orbit crew has the ability to access medical data/information via an intuitive and crew-friendly solution to aid in the treatment of a medical condition. c. Develop a common data management framework that can be ubiquitously used to automate repetitive data collection, management, and communications tasks for all activities pertaining to crew health and life sciences. d. Ensure crew access to medical data during periods of restricted ground communication. e. Develop a common data management framework that

  11. Space Research Benefits Demonstrated

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Angie Jackman, a NASA project manager in microgravity research, demonstrates the enhanced resilience of undercooled metal alloys as compared to conventional alloys. Experiments aboard the Space Shuttle helped scientists refine their understanding of the physical properties of certain metal alloys when undercooled (i.e., kept liquid below their normal solidification temperature). This new knowledge then allowed scientists to modify a terrestrial production method so they can now make limited quantities marketed under the Liquid Metal trademark. The exhibit was a part of the NASA outreach activity at AirVenture 2000 sponsored by the Experimental Aircraft Association in Oshkosh, WI.

  12. Human respiratory mechanics demonstration model.

    PubMed

    Anderson, Janelle; Goplen, Chris; Murray, Lynn; Seashore, Kristen; Soundarrajan, Malini; Lokuta, Andrew; Strang, Kevin; Chesler, Naomi

    2009-03-01

    Respiratory mechanics is a difficult topic for instructors and students alike. Existing respiratory mechanics models are limited in their abilities to demonstrate any effects of rib cage movement on alveolar and intrapleural pressures. We developed a model that can be used in both large and small classroom settings. This model contains digital pressure displays and computer integration for real-time demonstration of pressure changes that correspond to the different phases of breathing. Moving the simulated diaphragm and rib cage causes a volume change that results in pressure changes visible on the digital sensors and computer display. Device testing confirmed the model's ability to accurately demonstrate pressure changes in proportion to physiological values. Classroom testing in 427 surveyed students showed improved understanding of respiratory concepts (P < 0.05). We conclude that our respiratory mechanics model is a valuable instructional tool and provide detailed instructions for those who would like to create their own. PMID:19261761

  13. A RESEARCH DEMONSTRATION TO ASSESS THE EFFECTIVENESS OF A SPECIAL LIVING UNIT WITHIN A UNIVERSITY DORMITORY SETTING FOR THE REHABILITATION OF STUDENTS DISABLED BY EMOTIONAL DISTURBANCE.

    ERIC Educational Resources Information Center

    SINNETT, E. ROBERT

    USE OF A RESIDENCE HALL AS A THERAPEUTIC MILIEU FOR DISTURBED COLLEGE STUDENTS IS DESCRIBED IN THIS REPORT OF A RESEARCH AND DEMONSTRATION STUDY. THE EXPERIMENTAL GROUP CONSISTED OF TEN DISTURBED STUDENTS, AND A CONTROL GROUP WAS COMPOSED OF 10 VOLUNTEER STUDENTS. ALL STUDENTS PARTICIPATED IN THE REGULAR RESIDENCE HALL PROGRAMS (ORGANIZATIONAL…

  14. A Robust, "One-Pot" Method for Acquiring Kinetic Data for Hammett Plots Used to Demonstrate Transmission of Substituent Effects in Reactions of Aromatic Ethyl Esters

    ERIC Educational Resources Information Center

    Yau, Hon Man; Haines, Ronald S.; Harper, Jason B.

    2015-01-01

    A "one-pot" method for acquiring kinetic data for the reactions of a series of substituted aromatic esters with potassium hydroxide using [supserscript 13]C NMR spectroscopy is described, which provides an efficient way to obtain sufficient data to demonstrate the Hammett equation in undergraduate laboratories. The method is…

  15. Residential Transactive Control Demonstration

    SciTech Connect

    Widergren, Steven E.; Fuller, Jason C.; Marinovici, Maria C.; Somani, Abhishek

    2014-02-19

    Arguably the most exciting aspect of the smart grid vision is the full participation of end-use resources with all forms of generation and energy storage in the reliable and efficient operation of an electric power system. Engaging all of these resources in a collaborative manner that respects the objectives of each resource, is sensitive to the system and local constraints of electricity flow, and scales to the large number of devices and systems participating is a grand challenge. Distributed decision-making system approaches have been presented and experimentation is underway. This paper reports on the preliminary findings of a residential demand response demonstration that uses the bidding transactions of supply and end-use air conditioning resources communicating with a real-time, 5 minute market to balance the various needs of the participants on a distribution feeder. The nature of the demonstration, the value streams being explored, and the operational scenarios implemented to characterize the system response are summarized along with preliminary findings.

  16. Vortex Apparatus and Demonstrations

    NASA Astrophysics Data System (ADS)

    Shakerin, Said

    2010-05-01

    Vortex flow, from millimeter to kilometer in scale, is important in many scientific and technological areas. Examples are seen in water strider locomotion, from industrial pipe flow (wastewater treatment) to air traffic control (safe distance between aircrafts on a runway ready for takeoff) to atmospheric studies.2-5 In this paper, we focus on a particular vortex known as bathtub vortex (BTV). It occurs when water is drained from a hole at the bottom of a container such as a bathtub or a sink under the action of gravity. The vortex has a funnel shape with a central air core, resembling a tornado. We have designed a portable apparatus to demonstrate bathtub vortex on a continual basis. The apparatus consists of a clear cylinder supported by a frame over a water reservoir and a submersible pump. Young and old have been equally amazed by watching the demonstrations at various public presentations held at the University of the Pacific recently. With material cost of less than 100, the apparatus can be easily fabricated and used at other universities. With a short set-up time, it is an ideal device for promoting science to the general public, and it can be used to enhance lectures in physics courses as well.

  17. SSME Key Operations Demonstration

    NASA Technical Reports Server (NTRS)

    Anderson, Brian; Bradley, Michael; Ives, Janet

    1997-01-01

    A Space Shuttle Main Engine (SSME) test program was conducted between August 1995 and May 1996 using the Technology Test Bed (TTB) Engine. SSTO vehicle studies have indicated that increases in the propulsion system operating range can save significant weight and cost at the vehicle level. This test program demonstrated the ability of the SSME to accommodate a wide variation in safe operating ranges and therefore its applicability to the SSTO mission. A total of eight tests were completed with four at Marshall Space Flight Center's Advanced Engine Test Facility and four at the Stennis Space Center (SSC) A-2 attitude test stand. Key demonstration objectives were: 1) Mainstage operation at 5.4 to 6.9 mixture ratio; 2) Nominal engine start with significantly reduced engine inlet pressures of 50 psia LOX and 38 psia fuel; and 3) Low power level operation at 17%, 22%, 27%, 40%, 45%, and 50% of Rated Power Level. Use of the highly instrumented TTB engine for this test series has afforded the opportunity to study in great detail engine system operation not possible with a standard SSME and has significantly contributed to a greater understanding of the capabilities of the SSME and liquid rocket engines in general.

  18. A Demonstration of Car Braking Instabilities.

    ERIC Educational Resources Information Center

    Irwin, Jack; Swinson, Derek

    1990-01-01

    Detailed are the construction of a demonstration car, apparatus and procedures used in the demonstration, and the analysis of the effects of car braking. The cases of rear-wheel and front-wheel braking are considered. (CW)

  19. Buried Waste Integrated Demonstration Plan

    SciTech Connect

    Kostelnik, K.M.

    1991-12-01

    This document presents the plan of activities for the Buried Waste Integrated Demonstration (BWID) program which supports the environmental restoration (ER) objectives of the Department of Energy (DOE) Complex. Discussed in this plan are the objectives, organization, roles and responsibilities, and the process for implementing and managing BWID. BWID is hosted at the Idaho National Engineering Laboratory (INEL), but involves participants from throughout the DOE Complex, private industry, universities, and the international community. These participants will support, demonstrate, and evaluate a suite of advanced technologies representing a comprehensive remediation system for the effective and efficient remediation of buried waste. The processes for identifying technological needs, screening candidate technologies for applicability and maturity, selecting appropriate technologies for demonstration, field demonstrating, evaluation of results and transferring technologies to environmental restoration programs are also presented. This document further describes the elements of project planning and control that apply to BWID. It addresses the management processes, operating procedures, programmatic and technical objectives, and schedules. Key functions in support of each demonstration such as regulatory coordination, safety analyses, risk evaluations, facility requirements, and data management are presented.

  20. Shuttle bay telerobotics demonstration

    NASA Technical Reports Server (NTRS)

    Chun, W.; Cogeos, P.

    1987-01-01

    A demonstration of NASA's robotics capabilities should be a balanced agenda of servicing and assembly tasks combined with selected key technical experiments. The servicing tasks include refueling and module replacement. Refueling involves the mating of special fluid connectors while module replacement requires an array of robotic technologies such as special tools, the arm of a logistics tool, and the precision mating of orbital replacement units to guides. The assembly task involves the construction of a space station node and truss structure. The technological experiments will focus on a few important issues: the precision manipulation of the arms by a teleoperator, the additional use of several mono camera views in conjunction with the stereo system, the use of a general purpose end effector versus a caddy of tools, and the dynamics involved with using a robot with a stabilizer.

  1. Fusion power demonstration

    SciTech Connect

    Henning, C.D.; Logan, B.G.

    1983-09-01

    As a satellite to the MARS (Mirror Advanced Reactor Study) a smaller, near-term device has been scoped, called the FPD (Fusion Power Demonstration). Envisioned as the next logical step toward a power reactor, it would advance the mirror fusion program beyond MFTF-B and provide an intermediate step toward commercial fusion power. Breakeven net electric power capability would be the goal such that no net utility power would be required to sustain the operation. A phased implementation is envisioned, with a deuterium checkout first to verify the plasma systems before significant neutron activation has occurred. Major tritium-related facilities would be installed with the second phase to produce sufficient fusion power to supply the recirculating power to maintain the neutral beams, ECRH, magnets and other auxiliary equipment.

  2. Jennings Demonstration PLant

    SciTech Connect

    Russ Heissner

    2010-08-31

    Verenium operated a demonstration plant with a capacity to produce 1.4 million gallons of cellulosic ethanol from agricultural resiues for about two years. During this time, the plant was able to evaluate the technical issues in producing ethanol from three different cellulosic feedstocks, sugar cane bagasse, energy cane, and sorghum. The project was intended to develop a better understanding of the operating parameters that would inform a commercial sized operation. Issues related to feedstock variability, use of hydrolytic enzymes, and the viability of fermentative organisms were evaluated. Considerable success was achieved with pretreatment processes and use of enzymes but challenges were encountered with feedstock variability and fermentation systems. Limited amounts of cellulosic ethanol were produced.

  3. Structural assembly demonstration experiment

    NASA Technical Reports Server (NTRS)

    Stokes, J. W.

    1982-01-01

    The experiment is of an operational variety, designed to assess crew capability in Large Space System (LSS) assembly. The six Structural Assembly Demonstration Experiment objectives include: (1) the establishment of a quantitative correlation between LSS neutral buoyancy simulation and on-orbit assembly operations in order to enhance the validity of those assembly simulations; (2) the quantitative study of the capabilities and mechanics of human assembly in an Extravehicular Activity environment; (3) the further corroboration of the LSS Assembly Analysis cost algorithm through the obtainment of hard data base information; (4) the verification of LSS assembly techniques and timeless, as well as the identification of crew imposed loads and assembly aid requirements and concepts; (5) verification of a Launch/Assembly Platform structure concept for other LSS missions; and (6) lastly, to advance thermal control concepts through a flexible heat pipe.

  4. Fusion Power Demonstration III

    SciTech Connect

    Lee, J.D.

    1985-07-01

    This is the third in the series of reports covering the Fusion Power Demonstration (FPD) design study. This volume considers the FPD-III configuration that incorporates an octopole end plug. As compared with the quadrupole end-plugged designs of FPD-I and FPD-II, this octopole configuration reduces the number of end cell magnets and shortens the minimum ignition length of the central cell. The end-cell plasma length is also reduced, which in turn reduces the size and cost of the end cell magnets and shielding. As a contiuation in the series of documents covering the FPD, this report does not stand alone as a design description of FPD-III. Design details of FPD-III subsystems that do not differ significantly from those of the FPD-II configuration are not duplicated in this report.

  5. Space Research Benefits Demonstrated

    NASA Technical Reports Server (NTRS)

    2000-01-01

    An entranced youngster watches a demonstration of the enhanced resilience of undercooled metal alloys as compared to conventional alloys. Steel bearings are dropped onto plates made of steel, titanium alloy, and zirconium liquid metal alloy, so-called because its molecular structure is amorphous and not crystalline. The bearing on the liquid metal plate bounces for a minute or more longer than on the other plates. Experiments aboard the Space Shuttle helped scientists refine their understanding of the physical properties of certain metal alloys when undercooled (i.e., kept liquid below their normal solidification temperature). This new knowledge then allowed scientists to modify a terrestrial production method so they can now make limited quantities marketed under the Liquid Metal trademark. The exhibit was a part of the NASA outreach activity at AirVenture 2000 sponsored by the Experimental Aircraft Association in Oshkosh, WI.

  6. An Inexpensive Resonance Demonstration

    ERIC Educational Resources Information Center

    Dukes, Phillip

    2005-01-01

    The phenomenon of resonance is applicable to almost every branch of physics. Without resonance, there wouldn't be televisions or stereos, or even swings on the playground. However, resonance also has undesirable side effects such as irritating noises in the car and the catastrophic events such as helicopters flying apart. In this article, the…

  7. Paramagnetism Paradoxes: Projectable Demonstrations

    ERIC Educational Resources Information Center

    Sauls, Frederick C.; Vitz, Ed

    2008-01-01

    Drops of oil in Mn(SO[subscript 4])(aq) and drops of the solution in oil show opposite effects when brought near a rare earth magnet. Oxygen, nitrogen, and air bubbles atop water show expected attraction, repulsion, and null behavior, respectively. Air bubbles atop aqueous Mn(SO[subscript 4]) show paradoxical behavior because the magnet's…

  8. Plug cluster module demonstration

    NASA Technical Reports Server (NTRS)

    Rousar, D. C.

    1978-01-01

    The low pressure, film cooled rocket engine design concept developed during two previous ALRC programs was re-evaluated for application as a module for a plug cluster engine capable of performing space shuttle OTV missions. The nominal engine mixture ratio was 5.5 and the engine life requirements were 1200 thermal cycles and 10 hours total operating life. The program consisted of pretest analysis; engine tests, performed using residual components; and posttest analysis. The pretest analysis indicated that operation of the operation of the film cooled engine at O/F = 5.5 was feasible. During the engine tests, steady state wall temperature and performance measurement were obtained over a range of film cooling flow rates, and the durability of the engine was demonstrated by firing the test engine 1220 times at a nominal performance ranging from 430 - 432 seconds. The performance of the test engine was limited by film coolant sleeve damage which had occurred during previous testing. The post-test analyses indicated that the nominal performance level can be increased to 436 seconds.

  9. Orbital construction demonstration study

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A conceptual design and program plan for an Orbital Construction Demonstration Article (OCDA) was developed that can be used for evaluating and establishing practical large structural assembly operations. A flight plan for initial placement and continued utility is presented as a basic for an entirely new shuttle payload line-item having great future potential benefit for space applications. The OCDA is a three-axis stabilized platform in low-earth orbit with many structural nodals for mounting large construction and fabrication equipments. This equipment would be used to explore methods for constructing the large structures for future missions. The OCDA would be supported at regular intervals by the shuttle. Construction experiments and consumables resupply are performed during shuttle visit periods. A 250 kw solar array provides sufficient power to support the shuttle while attached to the OCDA and to run construction experiments at the same time. Wide band communications with a Telemetry and Data Relay Satellite compatible high gain antenna can be used between shuttle revisits to perform remote controlled, TV assisted construction experiments.

  10. NASA Bioreactor Demonstration System

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Leland W. K. Chung (left), Director, Molecular Urology Therapeutics Program at the Winship Cancer Institute at Emory University, is principal investigator for the NASA bioreactor demonstration system (BDS-05). With him is Dr. Jun Shu, an assistant professor of Orthopedics Surgery from Kuming Medical University China. The NASA Bioreactor provides a low turbulence culture environment which promotes the formation of large, three-dimensional cell clusters. Due to their high level of cellular organization and specialization, samples constructed in the bioreactor more closely resemble the original tumor or tissue found in the body. The Bioreactor is rotated to provide gentle mixing of fresh and spent nutrient without inducing shear forces that would damage the cells. The work is sponsored by NASA's Office of Biological and Physical Research. The bioreactor is managed by the Biotechnology Cell Science Program at NASA's Johnson Space Center (JSC). NASA-sponsored bioreactor research has been instrumental in helping scientists to better understand normal and cancerous tissue development. In cooperation with the medical community, the bioreactor design is being used to prepare better models of human colon, prostate, breast and ovarian tumors. Cartilage, bone marrow, heart muscle, skeletal muscle, pancreatic islet cells, liver and kidney are just a few of the normal tissues being cultured in rotating bioreactors by investigators. Credit: Emory University.

  11. Factors that Contribute towards Improving Learning Effectiveness Using a Specific Learning Management System (LMS) at the Military Academy (MA): A Demonstration

    ERIC Educational Resources Information Center

    Pretorius, Andre

    2010-01-01

    Purpose: The purpose of this paper is to explore the factors that contribute towards learning effectiveness in e-learning courses. A review of previous studies was carried out to determine those factors that are most applicable to a tertiary teaching environment and to propose a model to assess effectiveness in online courses. The virtual learning…

  12. Unmanned space vehicle technology demonstrator

    NASA Astrophysics Data System (ADS)

    Tancredi, U.; Accardo, D.; Grassi, M.; Curreri, F.

    2007-02-01

    The unmanned space vehicle (USV) program has been undertaken by the Italian Center for Aerospace Research with the aim of developing flying test beds of next generation reentry launch vehicles. In this framework, the development of small demonstrators is also foreseen to validate technological and operational aspects of full-scale vehicles and missions. In this paper, a small-scale demonstrator of the sub-orbital re-entry test mission of the USV program is described. Both mission profile and objectives are very challenging in terms of demonstrator guidance, navigation and control. After a short description of the mission and demonstrator architectures, particular emphasis is given to the guidance and navigation analysis. To this end, mission objectives and reduced-scale system constaints are integrated and translated into innovative guidance solutions relying on optimization techniques. Then, performance of a commercial-off-the-shelf GPS-aided, miniature inertial navigation system over the proposed trajectories is evaluated by Monte Carlo analysis. Standalone inertial and GPS-aided inertial navigation performance is also compared considering GPS loss conditions due to antenna plasma effects.

  13. Kinesthetic Transverse Wave Demonstration

    NASA Astrophysics Data System (ADS)

    Pantidos, Panagiotis; Patapis, Stamatis

    2005-09-01

    This is a variation on the String and Sticky Tape demonstration "The Wave Game," suggested by Ron Edge. A group of students stand side by side, each one holding a card chest high with both hands. The teacher cues the first student to begin raising and lowering his card. When he starts lowering his card, the next student begins to raise his. As succeeding students move their cards up and down, a wave such as that shown in the figure is produced. To facilitate the process, students' motions were synchronized with the ticks of a metronome (without such synchronization it was nearly impossible to generate a satisfactory wave). Our waves typically had a frequency of about 1 Hz and a wavelength of around 3 m. We videotaped the activity so that the students could analyze the motions. The (17-year-old) students had not received any prior instruction regarding wave motion and did not know beforehand the nature of the exercise they were about to carry out. During the activity they were asked what a transverse wave is. Most of them quickly realized, without teacher input, that while the wave propagated horizontally, the only motion of the transmitting medium (them) was vertical. They located the equilibrium points of the oscillations, the crests and troughs of the waves, and identified the wavelength. The teacher defined for them the period of the oscillations of the motion of a card to be the total time for one cycle. The students measured this time and then several asserted that it was the same as the wave period. Knowing the length of the waves and the number of waves per second, the next step can easily be to find the wave speed.

  14. VLBI2010 Demonstrator Project

    NASA Astrophysics Data System (ADS)

    Niell, A.

    2008-12-01

    . Observations demonstrating the full four-band configuration are planned for October. In this talk the results of these tests, the improvements that are anticipated for the operational VLBI2010 network, and the status of other developments in the next generation of geodetic VLBI systems will be presented. * Bruce Whittier, Mike Titus, Jason SooHoo, Dan Smythe, Alan Rogers, Jay Redmond, Mike Poirier, Chuck Kodak, Alan Hinton, Ed Himwich, Skip Gordon, Mark Evangelista, Irv Diegel, Brian Corey, Tom Clark, Chris Beaudoin (in reverse alphabetical order)

  15. Dabigatran, a direct thrombin inhibitor, blocks differentiation of normal fibroblasts to a myofibroblast phenotype and demonstrates anti-fibrotic effects on scleroderma lung fibroblasts

    PubMed Central

    Bogatkevich, Galina S.; Ludwicka-Bradley, Anna; Silver, Richard M.

    2010-01-01

    Myofibroblasts are the principal mesenchymal cells responsible for tissue remodeling, collagen deposition, and the restrictive nature of lung parenchyma associated with pulmonary fibrosis. We previously reported that thrombin activates protease-activated receptor (PAR)-1 thereby inducing normal lung fibroblasts to differentiate to a myofibroblast phenotype resembling scleroderma lung myofibroblasts. Here we demonstrate that the thrombin inhibitor dabigatran inhibits in a dose-dependant manner thrombin's induction of myofibroblasts. Dabigatran inhibits thrombin-induced cell proliferation, α-smooth muscle actin (α-SMA) expression and organization, and the production of collagen and connective tissue growth factor (CTGF). Moreover, when treated with dabigatran scleroderma lung myofibroblasts produce less CTGF, α-SMA, and collagen type I. We conclude that dabigatran restrains important profibrotic events in lung fibroblasts and that this oral direct thrombin inhibitor warrants study as a potential anti-fibrotic drug for the treatment of fibrosing lung diseases, e.g. scleroderma lung disease and idiopathic pulmonary fibrosis. PMID:19877031

  16. Effectiveness and safety of the Proxis system in demonstrating retrograde coronary blood flow during proximal occlusion and in capturing embolic material.

    PubMed

    Sievert, Horst; Wahr, Dennis W; Schuler, Gerhard; Schofer, Joachim J; Sutsch, Gabor; Pavliska, Jim; Skowasch, Marijke

    2004-11-01

    The Feasibility And Safety Trial for its embolic protection device during transluminal intervention in coronary vessels: a European Registry (FASTER) was designed to demonstrate that (1) the Proxis embolic protection system can control anterograde flow and reverse blood flow in native coronary arteries and saphenous vein grafts; and (2) this system can capture embolic debris. Percutaneous coronary intervention on stenotic coronary lesions revolutionized treatment of coronary disease, but is associated with the risk of major adverse cardiac events. This prospective, nonrandomized, multicenter clinical feasibility and safety study enrolled 40 patients with 51 lesions at 4 centers who underwent treatment of stenotic lesions with proximal emboli protection (Proxis system). Proxis was successfully used 95% of the time, and embolic debris was qualitatively identified in all cases. Major adverse cardiac events occurred in 2 patients (5.0%): 1 late in-stent thrombosis resulting in death and 1 non-Q-wave infarction when a lesion was crossed before deployment of the Proxis system. Mean vessel occlusion time was 4.3 +/- 2.4 minutes. Native flow reversal was sufficient in 31 patients, with a mean aspirate volume of 11.8 +/- 6.5 ml. When the infusion catheter was used to augment reflow, mean occlusion time was 4.6 minutes. In conclusion, this trial is the first to demonstrate that retrograde blood flow can be achieved during proximal occlusion and that the Proxis system can be used safely during intervention of saphenous vein grafts and native coronary arterial lesions to capture embolic material. PMID:15518607

  17. LIMB Demonstration Project Extension and Coolside Demonstration. [Final report

    SciTech Connect

    Goots, T.R.; DePero, M.J.; Nolan, P.S.

    1992-11-10

    This report presents results from the limestone Injection Multistage Burner (LIMB) Demonstration Project Extension. LIMB is a furnace sorbent injection technology designed for the reduction of sulfur dioxide (SO{sub 2}) and nitrogen oxides (NO{sub x}) emissions from coal-fired utility boilers. The testing was conducted on the 105 Mwe, coal-fired, Unit 4 boiler at Ohio Edison`s Edgewater Station in Lorain, Ohio. In addition to the LIMB Extension activities, the overall project included demonstration of the Coolside process for S0{sub 2} removal for which a separate report has been issued. The primary purpose of the DOE LIMB Extension testing, was to demonstrate the generic applicability of LIMB technology. The program sought to characterize the S0{sub 2} emissions that result when various calcium-based sorbents are injected into the furnace, while burning coals having sulfur content ranging from 1.6 to 3.8 weight percent. The four sorbents used included calcitic limestone, dolomitic hydrated lime, calcitic hydrated lime, and calcitic hydrated lime with a small amount of added calcium lignosulfonate. The results include those obtained for the various coal/sorbent combinations and the effects of the LIMB process on boiler and plant operations.

  18. Smart Sensor Demonstration Payload

    NASA Technical Reports Server (NTRS)

    Schmalzel, John; Bracey, Andrew; Rawls, Stephen; Morris, Jon; Turowski, Mark; Franzl, Richard; Figueroa, Fernando

    2010-01-01

    Sensors are a critical element to any monitoring, control, and evaluation processes such as those needed to support ground based testing for rocket engine test. Sensor applications involve tens to thousands of sensors; their reliable performance is critical to achieving overall system goals. Many figures of merit are used to describe and evaluate sensor characteristics; for example, sensitivity and linearity. In addition, sensor selection must satisfy many trade-offs among system engineering (SE) requirements to best integrate sensors into complex systems [1]. These SE trades include the familiar constraints of power, signal conditioning, cabling, reliability, and mass, and now include considerations such as spectrum allocation and interference for wireless sensors. Our group at NASA s John C. Stennis Space Center (SSC) works in the broad area of integrated systems health management (ISHM). Core ISHM technologies include smart and intelligent sensors, anomaly detection, root cause analysis, prognosis, and interfaces to operators and other system elements [2]. Sensor technologies are the base fabric that feed data and health information to higher layers. Cost-effective operation of the complement of test stands benefits from technologies and methodologies that contribute to reductions in labor costs, improvements in efficiency, reductions in turn-around times, improved reliability, and other measures. ISHM is an active area of development at SSC because it offers the potential to achieve many of those operational goals [3-5].

  19. DEVELOPMENT AND DEMONSTRATION OF THE EFFECTIVENESS OF USING PROGRAMED MATERIAL FOR TEACHING FUNDAMENTAL TOOLS AND TECHNIQUES REQUIRED FOR ENGLISH COMPOSITION AT THE UNIVERSITY LEVEL. FINAL REPORT.

    ERIC Educational Resources Information Center

    TRIMBLE, MARTHA S.

    THIS STUDY WAS SET UP TO DETERMINE THE EFFECTIVENESS OF USING PROGRAMED MATERIAL IN SPELLING, DICTION, AND SENTENCE ARRANGEMENT AND PARAGRAPH COHERENCE FOR (1) IMPROVEMENT IN THE LANGUAGE HABITS OF THREE TYPES OF STUDENTS AT COLORADO STATE UNIVERSITY AND (2) ECONOMY IN TIME AND PERSONNEL REQUIRED FOR INSTRUCTION OF THESE STUDENTS. ONE EXPERIMENTAL…

  20. MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case–control samples

    PubMed Central

    Aberg, Karolina A; McClay, Joseph L; Nerella, Srilaxmi; Xie, Lin Y; Clark, Shaunna L; Hudson, Alexandra D; Bukszár, Jozsef; Adkins, Daniel; Consortium, Swedish Schizophrenia; Hultman, Christina M; Sullivan, Patrick F; Magnusson, Patrik KE; van den Oord, Edwin JCG

    2013-01-01

    Aim We studied the use of methyl-CpG binding domain (MBD) protein-enriched genome sequencing (MBD-seq) as a cost-effective screening tool for methylome-wide association studies (MWAS). Materials & methods Because MBD-seq has not yet been applied on a large scale, we first developed and tested a pipeline for data processing using 1500 schizophrenia cases and controls plus 75 technical replicates with an average of 68 million reads per sample. This involved the use of technical replicates to optimize quality control for multi- and duplicate-reads, an in silico experiment to identify CpGs in loci with alignment problems, CpG coverage calculations based on multiparametric estimates of the fragment size distribution, a two-stage adaptive algorithm to combine data from correlated adjacent CpG sites, principal component analyses to control for confounders and new software tailored to handle the large data set. Results We replicated MWAS findings in independent samples using a different technology that provided single base resolution. In an MWAS of age-related methylation changes, one of our top findings was a previously reported robust association involving GRIA2. Our results also suggested that owing to the many confounding effects, a considerable challenge in MWAS is to identify those effects that are informative about disease processes. Conclusion This study showed the potential of MBD-seq as a cost-effective tool in large-scale disease studies. PMID:23244307

  1. Effects of Project, Inquiry and Lecture-Demonstration Teaching Methods on Senior Secondary Students' Achievement in Separation of Mixtures Practical Test

    ERIC Educational Resources Information Center

    Sola, Agboola Omowunmi; Ojo, Oloyede Ezekiel

    2007-01-01

    This study assessed and compared the relative effectiveness of three methods for teaching and conducting experiments in separation of mixtures in chemistry. A pre-test, post-test experimental design with a control group was used. Two hundred and thirty three randomly selected Senior Secondary School I (SSS I) chemistry students were drawn from…

  2. Demonstrating Cost-Effective Marker Assisted Selection for Biomass Yield in Red Clover (Trifolium pratense L.) – Part 1: Paternity Testing

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many methods have been proposed to incorporate molecular markers into breeding programs. Presented is a cost effective marker assisted selection (MAS) methodology that utilizes individual plant phenotypes, seed production-based knowledge of maternity, and molecular marker-determined paternity. Proge...

  3. The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing

    PubMed Central

    2009-01-01

    Background Recent studies have shown that the fecal microbiota is generally resilient to short-term antibiotic administration, but some bacterial taxa may remain depressed for several months. Limited information is available about the effect of antimicrobials on small intestinal microbiota, an important contributor to gastrointestinal health. The antibiotic tylosin is often successfully used for the treatment of chronic diarrhea in dogs, but its exact mode of action and its effect on the intestinal microbiota remain unknown. The aim of this study was to evaluate the effect of tylosin on canine jejunal microbiota. Tylosin was administered at 20 to 22 mg/kg q 24 hr for 14 days to five healthy dogs, each with a pre-existing jejunal fistula. Jejunal brush samples were collected through the fistula on days 0, 14, and 28 (14 days after withdrawal of tylosin). Bacterial diversity was characterized using massive parallel 16S rRNA gene pyrosequencing. Results Pyrosequencing revealed a previously unrecognized species richness in the canine small intestine. Ten bacterial phyla were identified. Microbial populations were phylogenetically more similar during tylosin treatment. However, a remarkable inter-individual response was observed for specific taxa. Fusobacteria, Bacteroidales, and Moraxella tended to decrease. The proportions of Enterococcus-like organisms, Pasteurella spp., and Dietzia spp. increased significantly during tylosin administration (p < 0.05). The proportion of Escherichia coli-like organisms increased by day 28 (p = 0.04). These changes were not accompanied by any obvious clinical effects. On day 28, the phylogenetic composition of the microbiota was similar to day 0 in only 2 of 5 dogs. Bacterial diversity resembled the pre-treatment state in 3 of 5 dogs. Several bacterial taxa such as Spirochaetes, Streptomycetaceae, and Prevotellaceae failed to recover at day 28 (p < 0.05). Several bacterial groups considered to be sensitive to tylosin increased in their

  4. ASTP science demonstration data analysis

    NASA Technical Reports Server (NTRS)

    Grodzka, P. G.; Bourgeois, S. V.

    1977-01-01

    Analyses of the Apollo-Soyuz science demonstrations on chemical foams and liquid spreading are presented. The chemical foams demonstation showed that aqueous foams and gas/liquid dispersions are more stable in low-g than on the ground. Unique chemical reactions in low-g foams and gas/liquid dispersions are therefore possible. Further ground tests on the formaldehyde clock reaction led to the rather surprising conclusions that surfaces can exert a nucleation effect and that long-range surface influences on chemical reaction rates are apparently operative.

  5. Effect of external magnetic field on IV 99mTc-labeled aminosilane-coated iron oxide nanoparticles: demonstration in a rat model: special report.

    PubMed

    Liberatore, Mauro; Barteri, Mario; Megna, Valentina; D'Elia, Piera; Rebonato, Stefania; Latini, Augusto; De Angelis, Francesca; Scaramuzzo, Francesca Anna; De Stefano, Maria Egle; Guadagno, Noemi Antonella; Chondrogiannis, Sotirios; Maffione, Anna Margherita; Rubello, Domenico; Pala, Alessandro; Colletti, Patrick M

    2015-02-01

    Among the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body. PMID:25551623

  6. A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

    PubMed

    Kogel, Ulrike; Schlage, Walter K; Martin, Florian; Xiang, Yang; Ansari, Sam; Leroy, Patrice; Vanscheeuwijck, Patrick; Gebel, Stephan; Buettner, Ansgar; Wyss, Christoph; Esposito, Marco; Hoeng, Julia; Peitsch, Manuel C

    2014-06-01

    Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology. We demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) compared with the reference research cigarette 3R4F. Rats were exposed to filtered air or to three concentrations of mainstream smoke (MS) from 3R4F, or to a high concentration of MS from a pMRTP. Histopathology revealed concentration-dependent changes in response to 3R4F that were irritative stress-related in nasal and bronchial epithelium, and inflammation-related in the lung parenchyma. For pMRTP, significant changes were seen in the nasal epithelium only. Transcriptomics data were obtained from nasal and bronchial epithelium and lung parenchyma. Concentration-dependent gene expression changes were observed following 3R4F exposure, with much smaller changes for pMRTP. A computational-modeling approach based on causal models of tissue-specific biological networks identified cell stress, inflammation, proliferation, and senescence as the most perturbed molecular mechanisms. These perturbations correlated with histopathological observations. Only weak perturbations were observed for pMRTP. In conclusion, a correlative evaluation of classical histopathology together with gene expression-based computational network models may facilitate a systems toxicology-based risk assessment, as shown for a pMRTP. PMID:24632068

  7. Demonstration of cost-effective NO{sub x} reduction on a regenerative sideport glass furnace using oxygen-enriched air staging

    SciTech Connect

    Mohr, P.; Neff, D.; Rue, D.

    1996-12-31

    The Gas Research Institute (GRI), the U.S. Department of Energy (DOE), and the Southern California Gas Company (SoCal) have joined with the development team of the Institute of Gas Technology (IGT), Combustion Tec, Inc. (CTI), and Air Products and Chemicals, Inc. (APCI) and provided support for extension of the oxygen-enriched air staging (OEAS) NO{sub x} control technology to natural gas-fired sideport regenerative glass melters. In previous demonstrations, the OEAS technology has successfully reduced NO{sub x} emissions by more than 50% on natural gas-fired endport regenerative glass melters without any adverse impacts on furnace performance or glass quality. In the current program, Owens-Brockway (OB) provided operations expertise and a 6 port pair, sideport furnace for field evaluation tests of OEAS. Background and initial test results for a single port pair and the complete furnace are presented along with CFD modeling results for OEAS on a single port pair of the sideport furnace. Modeling results confirm the capacity of OEAS to provide significant NO{sub x} reduction and CO burnout while maintaining or increasing thermal efficiency and furnace production rate.

  8. Nurses' Health Study: demonstrating the impact of research, and adapting new measures and approaches to increase relevance and effect of cohort studies.

    PubMed

    Colditz, Graham A

    2016-01-01

    The Nurses' Health Study, a cohort of 121 701 female registered nurses, was established in 1976 to prospectively address the relationship between the use of oral contraceptives and the risk of breast cancer. Through follow-up questionnaires every 2 years, exposures have been updated and new exposure assessments added. Repeated measures have allowed a broad range of analyses, including change measures and risk according to time since exposure. Responding to emerging public health issues and accessing new measures (such as exposure to silicone implants, air pollution and the built environment) has allowed investigators to address an evolving spectrum of topics. Prospective data on a wide range of chronic conditions have allowed assessment of preventable fractions of diseases, development of risk prediction models, and other applications that bring data to bear on translation of epidemiologic findings to health policy and practice. The aim of this report is to highlight the features of the Nurses' Health Study and other cohorts that demonstrate continuing contributions to the changing epidemiology of chronic conditions. PMID:27421340

  9. Potential control of Aedes aegypti (Diptera: Culicidae) with Piper aduncum L. (Piperaceae) extracts demonstrated by chromosomal biomarkers and toxic effects on interphase nuclei.

    PubMed

    Rafael, M S; Hereira-Rojas, W J; Roper, J J; Nunomura, S M; Tadei, W P

    2008-01-01

    Dillapiol, a phenylpropanoid isolate from essential oils of leaves of Piper aduncum (Piperaceae), has insecticidal, fungicidal and antimicrobial activities. The insecticidal activity of dillapiol was tested in vivo on the larvae and pupae of Aedes aegypti, the mosquito vector of dengue. Specifically, the effect of dillapiol on the formation of micronuclei and chromosome aberrations was analyzed. Dillapiol treatments comprised two concentrations of 200 and 400 micro dissolved in well water, and a pure well water control used to rear four generations of mosquitoes. Micronuclei occurred in mitotic diploid and tetraploid chromosomes of larvae; nuclear abnormalities also occurred in interphase, metaphase, telophase, and single nucleus cells of pupae. Mortality, oviposition, chromosome breakage, and anaphase bridges were significantly greater in the extract treatments than in controls. The genotoxic effects of dillapiol described here suggest that this natural product may be a useful alternative for the control of A. aegypti. PMID:18767246

  10. Demonstration of Hole Transport and Voltage Equilibration in Self-Assembled π-Conjugated Peptide Nanostructures Using Field-Effect Transistor Architectures.

    PubMed

    Besar, Kalpana; Ardoña, Herdeline Ann M; Tovar, John D; Katz, Howard E

    2015-12-22

    π-Conjugated peptide materials are attractive for bioelectronics due to their unique photophysical characteristics, biofunctional interfaces, and processability under aqueous conditions. In order to be relevant for electrical applications, these types of materials must be able to support the passage of current and the transmission of applied voltages. Presented herein is an investigation of both the current and voltage transmission activities of one-dimensional π-conjugated peptide nanostructures. Observations of the nanostructures as both semiconducting and gate layers in organic field-effect transistors (OFETs) were made, and the effect of systematic changes in amino acid composition on the semiconducting/conducting functionality of the nanostructures was investigated. These molecular variations directly impacted the hole mobility values observed for the nanomaterial active layers over 3 orders of magnitude (∼0.02 to 5 × 10(-5) cm(2) V(-1) s(-1)) when the nanostructures had quaterthiophene cores and the assembled peptide materials spanned source and drain electrodes. Peptides without the quaterthiophene core were used as controls and did not show field-effect currents, verifying that the transport properties of the nanostructures rely on the semiconducting behavior of the π-electron core and not just ionic rearrangements. We also showed that the nanomaterials could act as gate electrodes and assessed the effect of varying the gate dielectric layer thickness in devices where the conventional organic semiconductor pentacene spanned the source and drain electrodes in a top-contact OFET, showing an optimum performance with 35-40 nm dielectric thickness. This study shows that these peptides that self-assemble in aqueous environments can be used successfully to transmit electronic signals over biologically relevant distances. PMID:26554697

  11. Using resistant prey demonstrates that Bt plants producing Cry1Ac, Cry2Ab, and Cry1F have no negative effects on Geocoris punctipes and Orius insidiosus.

    PubMed

    Tian, Jun-Ce; Long, Li-Ping; Wang, Xiang-Ping; Naranjo, Steven E; Romeis, Jörg; Hellmich, Richard L; Wang, Ping; Shelton, Anthony M

    2014-02-01

    Geocoris punctipes (Say) and Orius insidiosus (Say) are generalist predators found in a wide range of crops, including cotton (Gossypium hirsutum L.) and maize (Zea mays L.), where they provide important biological control services by feeding on an array of pests, including eggs and small larvae of caterpillars. A high percentage of cotton and maize in the United States and several other countries are transgenic cultivars that produce one or more of the insecticidal Cry proteins of Bacillus thuringiensis Berliner (Bt). Here we quantify effects of three Cry proteins on the life history of these predators over two generations when they are exposed to these Cry proteins indirectly through their prey. To eliminate the confounding prey quality effects that can be introduced by Bt-susceptible prey, we used Cry1Ac/Cry2Ab-resistant Trichoplusia ni (Hübner) and Cry1 F-resistant Spodoptera frugiperda (J.E. Smith) in a series of tri-trophic studies. Survival, development, adult mass, fecundity, and fertility were similar when predators consumed larvae feeding on Cry1Ac/Cry2Ab cotton or Cry1 F maize compared with prey feeding on isogenic or near-isogenic cotton or maize. Repeated exposure of the same initial cohort over a second generation also resulted in no differences in life-history traits when feeding on non-Bt- or Bt-fed prey. Enzyme-linked immunosorbent assay showed that predators were exposed to Bt Cry proteins from their prey and that these proteins became increasingly diluted as they moved up the food chain. Results show a clear lack of effect of three common and widespread Cry proteins on these two important predator species. The use of resistant insects to eliminate prey quality effects provides a robust and meaningful assessment of exposure and hazard. PMID:24472212

  12. Favorite Demonstrations: Gaseous Diffusion: A Demonstration of Graham's Law.

    ERIC Educational Resources Information Center

    Kauffman, George B.; Ebner, Ronald D.

    1985-01-01

    Describes a demonstration in which gaseous ammonia and hydrochloric acid are used to illustrate rates of diffusion (Graham's Law). Simple equipment needed for the demonstration include a long tube, rubber stoppes, and cotton. Two related demonstrations are also explained. (DH)

  13. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.

    PubMed

    Deredge, Daniel; Li, Jiawen; Johnson, Kenneth A; Wintrode, Patrick L

    2016-05-01

    New nonnucleoside analogs are being developed as part of a multi-drug regimen to treat hepatitis C viral infections. Particularly promising are inhibitors that bind to the surface of the thumb domain of the viral RNA-dependent RNA polymerase (NS5B). Numerous crystal structures have been solved showing small molecule non-nucleoside inhibitors bound to the hepatitis C viral polymerase, but these structures alone do not define the mechanism of inhibition. Our prior kinetic analysis showed that nonnucleoside inhibitors binding to thumb site-2 (NNI2) do not block initiation or elongation of RNA synthesis; rather, they block the transition from the initiation to elongation, which is thought to proceed with significant structural rearrangement of the enzyme-RNA complex. Here we have mapped the effect of three NNI2 inhibitors on the conformational dynamics of the enzyme using hydrogen/deuterium exchange kinetics. All three inhibitors rigidify an extensive allosteric network extending >40 Å from the binding site, thus providing a structural rationale for the observed disruption of the transition from distributive initiation to processive elongation. The two more potent inhibitors also suppress slow cooperative unfolding in the fingers extension-thumb interface and primer grip, which may contribute their stronger inhibition. These results establish that NNI2 inhibitors act through long range allosteric effects, reveal important conformational changes underlying normal polymerase function, and point the way to the design of more effective allosteric inhibitors that exploit this new information. PMID:27006396

  14. Transfer-free graphene synthesis on sapphire by catalyst metal agglomeration technique and demonstration of top-gate field-effect transistors

    SciTech Connect

    Miyoshi, Makoto Arima, Yukinori; Kubo, Toshiharu; Egawa, Takashi; Mizuno, Masaya; Soga, Tetsuo

    2015-08-17

    Transfer-free graphene synthesis was performed on sapphire substrates by using the catalyst metal agglomeration technique, and the graphene film quality was compared to that synthesized on sputtered SiO{sub 2}/Si substrates. Raman scattering measurements indicated that the graphene film on sapphire has better structural qualities than that on sputtered SiO{sub 2}/Si substrates. The cross-sectional transmission microscopic study also revealed that the film flatness was drastically improved by using sapphire substrates instead of sputtered SiO{sub 2}/Si substrates. These quality improvements seemed to be due the chemical and thermal stabilities of sapphire. Top-gate field-effect transistors were fabricated using the graphene films on sapphire, and it was confirmed that their drain current can be modulated with applied gate voltages. The maximum field-effect mobilities were estimated to be 720 cm{sup 2}/V s for electrons and 880 cm{sup 2}/V s for holes, respectively.

  15. Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects.

    PubMed

    Hannan, Fadil M; Howles, Sarah A; Rogers, Angela; Cranston, Treena; Gorvin, Caroline M; Babinsky, Valerie N; Reed, Anita A; Thakker, Clare E; Bockenhauer, Detlef; Brown, Rosalind S; Connell, John M; Cook, Jacqueline; Darzy, Ken; Ehtisham, Sarah; Graham, Una; Hulse, Tony; Hunter, Steven J; Izatt, Louise; Kumar, Dhavendra; McKenna, Malachi J; McKnight, John A; Morrison, Patrick J; Mughal, M Zulf; O'Halloran, Domhnall; Pearce, Simon H; Porteous, Mary E; Rahman, Mushtaqur; Richardson, Tristan; Robinson, Robert; Scheers, Isabelle; Siddique, Haroon; Van't Hoff, William G; Wang, Timothy; Whyte, Michael P; Nesbit, M Andrew; Thakker, Rajesh V

    2015-09-15

    The adaptor protein-2 sigma subunit (AP2σ2) is pivotal for clathrin-mediated endocytosis of plasma membrane constituents such as the calcium-sensing receptor (CaSR). Mutations of the AP2σ2 Arg15 residue result in familial hypocalciuric hypercalcaemia type 3 (FHH3), a disorder of extracellular calcium (Ca(2+) o) homeostasis. To elucidate the role of AP2σ2 in Ca(2+) o regulation, we investigated 65 FHH probands, without other FHH-associated mutations, for AP2σ2 mutations, characterized their functional consequences and investigated the genetic mechanisms leading to FHH3. AP2σ2 mutations were identified in 17 probands, comprising 5 Arg15Cys, 4 Arg15His and 8 Arg15Leu mutations. A genotype-phenotype correlation was observed with the Arg15Leu mutation leading to marked hypercalcaemia. FHH3 probands harboured additional phenotypes such as cognitive dysfunction. All three FHH3-causing AP2σ2 mutations impaired CaSR signal transduction in a dominant-negative manner. Mutational bias was observed at the AP2σ2 Arg15 residue as other predicted missense substitutions (Arg15Gly, Arg15Pro and Arg15Ser), which also caused CaSR loss-of-function, were not detected in FHH probands, and these mutations were found to reduce the numbers of CaSR-expressing cells. FHH3 probands had significantly greater serum calcium (sCa) and magnesium (sMg) concentrations with reduced urinary calcium to creatinine clearance ratios (CCCR) in comparison with FHH1 probands with CaSR mutations, and a calculated index of sCa × sMg/100 × CCCR, which was ≥ 5.0, had a diagnostic sensitivity and specificity of 83 and 86%, respectively, for FHH3. Thus, our studies demonstrate AP2σ2 mutations to result in a more severe FHH phenotype with genotype-phenotype correlations, and a dominant-negative mechanism of action with mutational bias at the Arg15 residue. PMID:26082470

  16. Experimental Demonstration of the Effectiveness of Electromagnetically Induced Transparency for Enhancing Cross-Phase Modulation in the Short-Pulse Regime

    NASA Astrophysics Data System (ADS)

    Dmochowski, Greg; Feizpour, Amir; Hallaji, Matin; Zhuang, Chao; Hayat, Alex; Steinberg, Aephraim M.

    2016-04-01

    We present an experiment using a sample of laser-cooled Rb atoms to show that cross-phase modulation schemes continue to benefit from electromagnetically induced transparency (EIT) even as the transparency window is made narrower than the signal bandwidth (i.e., for signal pulses much shorter than the response time of the EIT system). Addressing concerns that narrow EIT windows might not prove useful for such applications, we show that while the peak phase shift saturates in this regime, it does not drop, and the time-integrated effect continues to scale inversely with EIT window width. This integrated phase shift is an important figure of merit for tasks such as the detection of single-photon-induced cross-phase shifts. Only when the window width approaches the system's dephasing rate γ does the peak phase shift begin to decrease, leading to an integrated phase shift that peaks when the window width is equal to 4 γ .

  17. Experimental Demonstration of the Effectiveness of Electromagnetically Induced Transparency for Enhancing Cross-Phase Modulation in the Short-Pulse Regime.

    PubMed

    Dmochowski, Greg; Feizpour, Amir; Hallaji, Matin; Zhuang, Chao; Hayat, Alex; Steinberg, Aephraim M

    2016-04-29

    We present an experiment using a sample of laser-cooled Rb atoms to show that cross-phase modulation schemes continue to benefit from electromagnetically induced transparency (EIT) even as the transparency window is made narrower than the signal bandwidth (i.e., for signal pulses much shorter than the response time of the EIT system). Addressing concerns that narrow EIT windows might not prove useful for such applications, we show that while the peak phase shift saturates in this regime, it does not drop, and the time-integrated effect continues to scale inversely with EIT window width. This integrated phase shift is an important figure of merit for tasks such as the detection of single-photon-induced cross-phase shifts. Only when the window width approaches the system's dephasing rate γ does the peak phase shift begin to decrease, leading to an integrated phase shift that peaks when the window width is equal to 4γ. PMID:27176519

  18. Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments

    SciTech Connect

    Dowdell, Stephen; Paganetti, Harald; Grassberger, Clemens

    2013-12-15

    Purpose: To compare motion effects in intensity modulated proton therapy (IMPT) lung treatments with different levels of intensity modulation.Methods: Spot scanning IMPT treatment plans were generated for ten lung cancer patients for 2.5Gy(RBE) and 12Gy(RBE) fractions and two distinct energy-dependent spot sizes (σ∼8–17 mm and ∼2–4 mm). IMPT plans were generated with the target homogeneity of each individual field restricted to <20% (IMPT{sub 20%}). These plans were compared to full IMPT (IMPT{sub full}), which had no restriction on the single field homogeneity. 4D Monte Carlo simulations were performed upon the patient 4DCT geometry, including deformable image registration and incorporating the detailed timing structure of the proton delivery system. Motion effects were quantified via comparison of the results of the 4D simulations (4D-IMPT{sub 20%}, 4D-IMPT{sub full}) with those of a 3D Monte Carlo simulation (3D-IMPT{sub 20%}, 3D-IMPT{sub full}) upon the planning CT using the equivalent uniform dose (EUD), V{sub 95} and D{sub 1}-D{sub 99}. The effects in normal lung were quantified using mean lung dose (MLD) and V{sub 90%}.Results: For 2.5Gy(RBE), the mean EUD for the large spot size is 99.9%± 2.8% for 4D-IMPT{sub 20%} compared to 100.1%± 2.9% for 4D-IMPT{sub full}. The corresponding values are 88.6%± 8.7% (4D-IMPT{sub 20%}) and 91.0%± 9.3% (4D-IMPT{sub full}) for the smaller spot size. The EUD value is higher in 69.7% of the considered deliveries for 4D-IMPT{sub full}. The V{sub 95} is also higher in 74.7% of the plans for 4D-IMPT{sub full}, implying that IMPT{sub full} plans experience less underdose compared to IMPT{sub 20%}. However, the target dose homogeneity is improved in the majority (67.8%) of plans for 4D-IMPT{sub 20%}. The higher EUD and V{sub 95} suggests that the degraded homogeneity in IMPT{sub full} is actually due to the introduction of hot spots in the target volume, perhaps resulting from the sharper in-target dose gradients. The

  19. Measurement of Pockels' coefficients and demonstration of the anisotropy of the elasto-optic effect in optical fibers under axial strain.

    PubMed

    Roselló-Mechó, X; Delgado-Pinar, M; Díez, A; Andrés, M V

    2016-07-01

    The elasto-optic effect in optical fibers under axial strain can be characterized by means of the whispering gallery mode (WGM) resonances of the fiber itself. This technique enables a direct measurement of the anisotropy, the determination of the individual Pockels' coefficients, and the study of the wavelength dependence. The method is based on a rigorous theoretical study of WGM resonances in cylindrical microresonators. The shift of the WGM resonances as a function of strain was measured for the TE and TM modes, showing a strong modal anisotropy. In particular, the shift rate for TE modes was 1.84 times the one for TM modes. From these measurements, experimental values for the Pockels' coefficients were obtained: p11=0.116 and p12=0.255 at 1531 nm, and p11=0.131 and p12=0.267 at 1064 nm. The dispersion of p44 with wavelength was shown to be 5%  μm-1. PMID:27367069

  20. Effects of light on direct and indirect defences against herbivores of young plants of Mallotus japonicus demonstrate a trade-off between two indirect defence traits

    PubMed Central

    Yamawo, Akira; Hada, Yoshio

    2010-01-01

    Background and Aims Although most studies on plant defence strategies have focused on a particular defence trait, some plant species develop multiple defence traits. To clarify the effects of light on the development of multiple defence traits, the production of direct and indirect defence traits of young plants of Mallotus japonicus were examined experimentally under different light conditions. Methods The young plants were cultivated under three light conditions in the experimental field for 3 months from May to July. Numbers of ants and pearl bodies on leaves in July were examined. After cultivation, the plants were collected and the developments of trichomes and pellucid dots, and extrafloral nectaries (EFNs) on the leaves were examined. On plants without nectar-collecting insects, the size of EFNs and the volume of extrafloral nectar secreted from the EFNs were examined. Key results Densities of trichomes and pellucid dots did not differ significantly among the plants under the different light conditions, suggesting that the chemical and physical defences function under both high and low light availability. The number of EFNs on the leaves did not differ significantly among the plants under the different light conditions, but there appeared to be a trade-off between the size of EFNs and the number of pearl bodies; the largest EFNs and the smallest number of pearl bodies were found under high light availability. EFN size was significantly correlated with the volume of extrafloral nectar secreted for 24 h. The number of ants on the plants was smaller under low light availability than under high and moderate light availability. Conclusions These results suggest that direct defence traits function regardless of light conditions, but light conditions affected the development of indirect defence traits. PMID:20472698

  1. Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver

    PubMed Central

    Harsányi, László; Budai, András; Pekli, Damján; Korsós, Diána; Horváth, Ildikó; Kovács, Noémi; Karlinger, Kinga

    2014-01-01

    Objectives In the early recognition of portal vein ligation (PVL) induced tumor progression, positron emission tomography and magnetic resonance imaging (PET/MRI) could improve diagnostic accuracy of conventionally used methods. It is unknown how PVL affects metabolic patterns of tumor free hepatic tissues. The aim of this preliminary study is to evaluate the effect of PVL on glucose metabolism, using PET/MRI imaging in healthy rat liver. Materials and Methods Male Wistar rats (n = 30) underwent PVL. 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/MRI imaging (nanoScan PET/MRI) and morphological/histological examination were performed before (Day 0) and 1, 2, 3, and 7 days after PVL. Dynamic PET data were collected and the standardized uptake values (SUV) for ligated and non-ligated liver lobes were calculated in relation to cardiac left ventricle (SUVVOI/SUVCLV) and mean liver SUV (SUVVOI/SUVLiver). Results PVL induced atrophy of ligated lobes, while non-ligated liver tissue showed compensatory hypertrophy. Dynamic PET scan revealed altered FDG kinetics in both ligated and non-ligated liver lobes. SUVVOI/SUVCLV significantly increased in both groups of lobes, with a maximal value at the 2nd postoperative day and returned near to the baseline 7 days after the ligation. After PVL, ligated liver lobes showed significantly higher tracer uptake compared to the non-ligated lobes (significantly higher SUVVOI/SUVLiver values were observed at postoperative day 1, 2 and 3). The homogenous tracer biodistribution observed before PVL reappeared by 7th postoperative day. Conclusion The observed alterations in FDG uptake dynamics should be taken into account during the assessment of PET data until the PVL induced atrophic and regenerative processes are completed. PMID:24599299

  2. [Cytotoxic effects of lead on the endocrine and exocrine sexual function of pubescent male and female rats. Demonstration of apoptotic activity].

    PubMed

    Gorbel, Fatma; Boujelbene, Manel; Makni-Ayadi, Fatma; Guermazi, Fadhel; Croute, Françoise; Soleilhavoup, Jean Pierre; el Feki, Abdelfettah

    2002-09-01

    , disorder deals with the hormonal function, which is affected at the early stages of poisoning, but is rapidly corrected; second, disorder deals with the genital tract, affecting the testis and the ovary, resulting in a reduced fertility in both P1 and P2 females, in spite of the presence of a normal oestrus. The cytotoxic effect of lead in males seems to be related to an apoptotic process. PMID:12481686

  3. The HumanIndexMod and New Calculations Demonstrating Heat Stress Effects All Aspects of Human Life Through Industry, Agriculture, and Daily Life.

    NASA Astrophysics Data System (ADS)

    Buzan, J. R.; Huber, M.

    2014-12-01

    We show the new climatic tool, HumanIndexMod (HIM), for quantitatively assessing key climatic variables that are critical for decision making. The HIM calculates 9 different heat stress and 4 moist thermodynamic quantities using meteorological inputs of T, P, and Q. These heat stress metrics are commonly used throughout the world. We show new methods for integrating and standardizing practices for applying these metrics with the latest Earth system models. We implemented the HIM into CLM4.5, a component of CESM, maintained by NCAR. These heat stress metrics cover philosophical approaches of comfort, physiology, and empirically based algorithms. The metrics are directly connected to the Urban, Canopy, Bare Ground, and Lake modules, to differentiate distinct regimes within each grid cell. The module calculates the instantaneous moisture-temperature covariance at every model time step and in every land surface type, capturing all aspects of non-linearity. The HIM uses the most accurate and computationally efficient moist thermodynamic algorithms available. Additionally, we show ways that the HIM may be effectively integrated into climate modeling and observations. The module is flexible. The user may decide which metrics to call, and there is an offline version of the HIM that is available to be used with weather and climate datasets. Examples include using high temporal resolution CMIP5 archive data, local weather station data, and weather and forecasting models. To provide comprehensive standards for applying the HIM to climate data, we executed a CLM4.5 simulation using the RCP8.5 boundary conditions. Preliminary results show moist thermodynamic and heat stress quantities have smaller variability in the extremes as compared to extremes in T (both at the 95th percentile). Additionally, the magnitude of the moist thermodynamic changes over land is similar to sea surface temperature changes. The metric changes from the early part of the 21st century as compared to the

  4. Experimental Study of the Behaviour of Gold in Calc-alkaline Arc Magmas : Demonstration of the Effect of Sulphur and Geological Implications on the Formation of Gold Deposits

    NASA Astrophysics Data System (ADS)

    Jego, S.; Pichavant, M.; Mavrogenes, J.

    2007-12-01

    -240 ppb) but globally increases with fO2, suggesting the implication of oxidized species in the dissolution of gold. Gold solubility in S-bearing charges appears much higher, ranging from ~500 to 5200 ppb. Gold content is higher in reduced than in moderately oxidizing conditions, and is not affected by melt composition. In very oxidizing conditions, Au solubility is low and nearly constant, and does not seem affected by the presence of S ; it only shows a dependence on fO2 by following the same trend than S-free charges. At ~NNO+1.5, gold content of silicate melt appears to be the result of a complex competition between fO2 and fS2, whereas under more reduced conditions, the effect of fS2 appears the strongest, leading to a direct dependence of gold solubility on sulfur content. This study shows conclusively that Au transport and concentration in silicic melts can be dramatically enhanced by the presence of sulphur. A major consequence is that sulfide crystallization is not likely to scavenge all Au present in the magma, but may allow gold-enriched residual magmas, especially those that are moderately reduced (NNO-1 to NNO+1.5), to be emplaced in the upper crust. Gold enrichment in porphyry- and epithermal- type deposits can be directly linked with sulfur incorporation and abundances in magmas.

  5. Exploration Medical System Demonstration Project

    NASA Technical Reports Server (NTRS)

    Chin, D. A.; McGrath, T. L.; Reyna, B.; Watkins, S. D.

    2011-01-01

    A near-Earth Asteroid (NEA) mission will present significant new challenges including hazards to crew health created by exploring a beyond low earth orbit destination, traversing the terrain of asteroid surfaces, and the effects of variable gravity environments. Limited communications with ground-based personnel for diagnosis and consultation of medical events require increased crew autonomy when diagnosing conditions, creating treatment plans, and executing procedures. Scope: The Exploration Medical System Demonstration (EMSD) project will be a test bed on the International Space Station (ISS) to show an end-to-end medical system assisting the Crew Medical Officers (CMO) in optimizing medical care delivery and medical data management during a mission. NEA medical care challenges include resource and resupply constraints limiting the extent to which medical conditions can be treated, inability to evacuate to Earth during many mission phases, and rendering of medical care by a non-clinician. The system demonstrates the integration of medical technologies and medical informatics tools for managing evidence and decision making. Project Objectives: The objectives of the EMSD project are to: a) Reduce and possibly eliminate the time required for a crewmember and ground personnel to manage medical data from one application to another. b) Demonstrate crewmember's ability to access medical data/information via a software solution to assist/aid in the treatment of a medical condition. c) Develop a common data management architecture that can be ubiquitously used to automate repetitive data collection, management, and communications tasks for all crew health and life sciences activities. d) Develop a common data management architecture that allows for scalability, extensibility, and interoperability of data sources and data users. e) Lower total cost of ownership for development and sustainment of peripheral hardware and software that use EMSD for data management f) Provide

  6. Integrated Payload Data Handling Demonstrator

    NASA Astrophysics Data System (ADS)

    FitzGeorge, T.; Wishart, A.; Hann, M.; Phan, N.; Carr, C. M.; Cupido, E.; Fox, P.; Oddy, T.; McGregor, A.; Marshall, A.; Waltham, N.

    2013-09-01

    An integrated Payload Data Handling System (IPDHS) is one in which multiple instruments share a central payload processor for their on-board data processing tasks. This offers a number of advantages over the conventional decentralised architecture. Savings in payload mass and power can be realised because the total processing resource is matched to the requirement, as opposed to the decentralised architecture where the processing resource is in effect the sum of all the applications. Overall development cost can be reduced using a common processor. At individual instrument level the potential benefits include a standardised application development environment, and the opportunity to run the instrument data handling application on a fully redundant and more powerful processor. This paper describes a joint programme by Astrium Ltd, SCISYS UK Limited, Imperial College London and RAL Space to implement a realistic demonstration of an I-PDHS using engineering models of flight instruments (a magnetometer and a camera) and a laboratory demonstrator of a central payload processor which is functionally representative of a flight design. The objective is to raise the Technology Readiness Level (TRL) of the centralised data processing technique by addressing the key areas of task partitioning to prevent fault propagation and the use of a common development process for the instrument applications. The project is supported by a UK Space Agency grant awarded under the National Space Technology Programme SpaceCITI scheme. The demonstration system is set up at the UK Space Agency's International Space Innovation Centre (ISIC) at Harwell and makes use of the ISIC Concurrent Design Facility (CDF).

  7. Industrial heat pump demonstration project

    SciTech Connect

    Not Available

    1988-09-01

    This booklet describes an industrial heat pump demonstration project conducted at a plant in Norwich, New York. The project required retrofitting an open-cycle heat pump to a single-effect, recirculating-type evaporator. The heat pump design uses an electrically driven centrifugal compressor to recover the latent heat of the water vapor generated by the evaporator. The compressed vapor is returned to the process, where it displaces the use of boiler steam. The goal was to reduce costs associated with operating the evaporator, which is used for reduction the water content of whey (a liquid by-product from cheese production). The retrofit equipment has now completed more than one year of successful operation. Heat pump coefficient of performance has been measured and is in the range of 14 to 18 under varying process conditions. Generalization of project results indicates that the demonstrated technology achieved attractive economics over a wide range of energy price assumptions, especially when the heat pump is applied to larger processes. 5 refs., 17 figs.

  8. Bentonite mat demonstration. Final report

    SciTech Connect

    Serrato, M.G.

    1994-12-30

    The Bentonite Mat Demonstration was developed to provide the Environmental Restoration Department with field performance characteristics and engineering data for an alternative closure cover system configuration. The demonstration was initiated in response to regulatory concerns regarding the use of an alternative cover system for future design configurations. These design considerations are in lieu of the US Environmental Protection Agency (EPA) Recommended Design for Closure Cover Systems and specifically a single compacted kaolin clay layer with a hydraulic conductivity of 1 {times} 10{sup {minus}7} cm/sec. This alternative configuration is a composite geosynthetic material hydraulic barrier consisting from bottom to top: 2 ft compacted sandy clay layer (typical local Savannah River Site soil type) that is covered by a bentonite mat--geosynthetic clay liner (GCL) and is overlaid by a 40 mil High Density Polyethylene (HDPE) geomembrane--flexible membrane liner. This effort was undertaken to obtain and document the necessary field performance/engineering data for future designs and meet regulatory technical requirements for an alternative cover system configuration. The composite geosynthetic materials hydraulic barrier is the recommended alternative cover system configuration for containment of hazardous and low level radiological waste layers that have a high potential of subsidence to be used at the Savannah River Site (SRS). This alternative configuration mitigates subsidence effects in providing a flexible, lightweight cover system to maintain the integrity of the closure. The composite geosynthetic materials hydraulic barrier is recommended for the Sanitary Landfill and Low Level Radiological Waste Disposal Facility (LLRWDF) Closures.

  9. National Orange Show Photovoltaic Demonstration

    SciTech Connect

    Dan Jimenez Sheri Raborn, CPA; Tom Baker

    2008-03-31

    National Orange Show Photovoltaic Demonstration created a 400KW Photovoltaic self-generation plant at the National Orange Show Events Center (NOS). The NOS owns a 120-acre state fairground where it operates an events center and produces an annual citrus fair known as the Orange Show. The NOS governing board wanted to employ cost-saving programs for annual energy expenses. It is hoped the Photovoltaic program will result in overall savings for the NOS, help reduce the State's energy demands as relating to electrical power consumption, improve quality of life within the affected grid area as well as increase the energy efficiency of buildings at our venue. In addition, the potential to reduce operational expenses would have a tremendous effect on the ability of the NOS to service its community.

  10. Halo and mirage demonstrations in atmospheric optics

    NASA Astrophysics Data System (ADS)

    Vollmer, Michael; Greenler, Robert

    2003-01-01

    Some laboratory demonstrations on atmospheric optics are presented. The focus is on dispersion effects in mirages, lateral mirages, and inferior mirages produced with small hot plates. We also show a demonstration of the upper-tangent-arc halo, produced with a hexagonal prism, rotating about two axes.

  11. Experiments and Demonstrations in Smoking Education.

    ERIC Educational Resources Information Center

    Gilbert, Glen G.; Ziady, Merrie

    This document contains experiments, demonstrations, and descriptions of computer software that may be useful in smoking education. Strategies are presented so that instructors can select the ones that are appropriate for their target populations. Experiments and demonstrations on the effects of smoking presented in this book are appropriate for…

  12. The Bernoulli or Coanda Conundrum and Other Classical Demonstration Myths

    NASA Astrophysics Data System (ADS)

    Stille, Dale

    2009-11-01

    Lecture Demonstration professionals have recently taken a closer look at demonstrations that were traditionally labeled ``Bernoulli Demonstrations'' in most textbooks. This examination has shown that in most cases the Coanda Effect, Magnus Effect, and Entrainment may be better explanations for most of these classic demonstrations. A discussion of other similarly classic demonstrations and some of their problems or misconceptions will also be presented.

  13. Demonstration Advanced Avionics System (DAAS), Phase 1

    NASA Technical Reports Server (NTRS)

    Bailey, A. J.; Bailey, D. G.; Gaabo, R. J.; Lahn, T. G.; Larson, J. C.; Peterson, E. M.; Schuck, J. W.; Rodgers, D. L.; Wroblewski, K. A.

    1981-01-01

    Demonstration advanced anionics system (DAAS) function description, hardware description, operational evaluation, and failure mode and effects analysis (FMEA) are provided. Projected advanced avionics system (PAAS) description, reliability analysis, cost analysis, maintainability analysis, and modularity analysis are discussed.

  14. A Dramatic Flame Test Demonstration.

    ERIC Educational Resources Information Center

    Johnson, Kristin A.; Schreiner, Rodney

    2001-01-01

    Flame tests are used for demonstration of atomic structure. Describes a demonstration that uses spray bottles filled with methanol and a variety of salts to produce a brilliantly colored flame. (Contains 11 references.) (ASK)

  15. Revisiting the Electric Pickle Demonstration

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 2005

    2005-01-01

    The electric pickle is a classic demonstration that is widely used in both high school and college settings to explain the general principles behind atomic emission. The demonstration fails to provide an interesting multi-line spectrum.

  16. Favorite Demonstrations for College Science

    ERIC Educational Resources Information Center

    Shmaefsky, Brian

    2004-01-01

    Peer-reviewed, classroom-tested, and tailored specifically for introductory science courses, Favorite Demonstrations is a complement to every college instructor's lesson plans. The book is an all-in-one compilation of 36 popular classroom demonstrations published since 1993 in the "Favorite Demonstration" column of NSTA's Journal of College …

  17. Demonstrations with a Vacuum: Old Demonstrations for New Vacuum Pumps.

    ERIC Educational Resources Information Center

    Greenslade, Thomas B., Jr.

    1989-01-01

    Explains mechanisms of 19th-century vacuum pumps. Describes demonstrations using the pump including guinea and feather tube, aurora tube, electric egg, Gassiots cascade, air mill, bell in vacuum, density and buoyancy of air, fountain in vacuum, mercury shower, palm and bladder glasses, Bacchus demonstration, pneumatic man-lifter, and Magdeburg…

  18. Real-time demonstration of QoS guaranteed 25-Gb/s PON prototype with Ethernet-PON MAC/PHY and cost-effective APD receivers for 100-Gb/s access networks.

    PubMed

    Lee, Han Hyub; Doo, Kyeong-Hwan; Mun, Sil-Gu; Kim, Kwangok; Lee, Jie Hyun; Kang, Sae-Kyoung; Park, Heuk; Park, Nowook; Park, Hyungjin; Chung, Hwan Seok

    2016-06-27

    We demonstrate a real-time 25-Gb/s PON prototype with ethernet-PON MAC/PHY, O-band transmitter, and cost-effective APD receivers. With applying parasitic inductance and capacitance reduction, the frequency response of 25-Gb/s APD ROSA with TO46-pacakge is improved to support high receiver sensitivity around -25 dBm at the BER of 10-3. The 30 dB power budget of 25 Gb/s downstream is achieved at the BER of 10-3. With long-term ethernet packet transmission, 25 Gigabit and 10 Gigabit ethernet traffics are successfully transmitted through the 20-km SMF over 14 hour's observation window. Furthermore, QoS and bandwidth re-assignment function of the 25-Gb/s PON prototype are successfully demonstrated with respect to residential, business and mobile backhaul services in ONUs. PMID:27410561

  19. Space telerobotics technology demonstration program

    NASA Technical Reports Server (NTRS)

    Szirmay, S. Z.; Schenker, P. S.; Rodriguez, G.; French, R. L.

    1987-01-01

    The paper reports the ongoing development of a telerobot demonstrator. The demonstrator is implemented as a laboratory-based research testbed, and will show proof-of-concept for supervised automation of space assembly, servicing, and repair operations. The demonstrator system features a hierarchically layered intelligent control architecture which enables automated planning and run-time sequencing of complex tasks by a supervisory human operator. The demonstrator also provides a full bilateral force-reflecting hand control teleroperations capability. The operator may switch smoothly between the automated and teleroperated tasking modes in run-time, either on a preplanned or operator-designated basis.

  20. Demonstration of an instrumented patch

    NASA Astrophysics Data System (ADS)

    Martinez, M.; Renaud, G.; Backman, D.; Genest, M.; Delannoy, M.

    2007-04-01

    The primary objective of this study was to demonstrate the effectiveness of various strain measurement techniques at detecting the disbonding of a composite repair patch and then using this information to validate a new capacitance based disbond detection technique. The instrumented repair patch was parametrically designed with the help of Finite Element Analysis (FEA) software to have a stress concentration at its tip. This stress concentration was designed to produce a disbond during fatigue testing, without the need for the introduction of any foreign material to create an artificial disbond condition. The aluminum substrate was grit blasted and the instrumented patch was bonded using FM ®73 adhesive, and was cured following the recommendations of the manufacturer. The geometric characteristics of the patch followed standard repair guidelines for such variables as material selection, taper angles and loading conditions, with the exception of the area designed for premature disbond. All test specimens were inspected using non-destructive testing technique (ultrasound pulse echo) to guarantee that no disbonding had occurred during curing of the specimen. The specimens were placed under fatigue loading to induce a disbond condition between the aluminum substrate and the patch. The specimens were cyclically loaded and strain gauges bonded to strategic locations on the aluminum and composite patch surface to be able to measure changes in surface strains as the disbond progressed. A Digital Image Correlation (DIC) system was also used to measure full field strains over the gauge length of the coupon. The DIC results were compared with the strain gauge data and were used to provide a qualitative measure of the load transfer in the bonded specimen, which clearly demonstrated the change in surface strain that occurred as the composite patch disbonded from the aluminum substrate. Thermoelastic Stress Analysis (TSA) was also used to measure surface strains on the

  1. Teaching and Demonstrating Classical Conditioning.

    ERIC Educational Resources Information Center

    Sparrow, John; Fernald, Peter

    1989-01-01

    Discusses classroom demonstrations of classical conditioning and notes tendencies to misrepresent Pavlov's procedures. Describes the design and construction of the conditioner that is used for demonstrating classical conditioning. Relates how students experience conditioning, generalization, extinction, discrimination, and spontaneous recovery.…

  2. A Demonstration of Acid Rain

    ERIC Educational Resources Information Center

    Fong, Man Wai

    2004-01-01

    A demonstration showing acid rain formation is described. Oxides of sulfur and nitrogen that result from the burning of fossil fuels are the major pollutants of acid rain. In this demonstration, SO[subscript 2] gas is produced by the burning of matches. An acid-base indicator will show that the dissolved gas turns an aqueous solution acidic.

  3. Optics Demonstrations Using Cylindrical Lenses

    ERIC Educational Resources Information Center

    Ivanov, Dragia; Nikolov, Stefan

    2015-01-01

    In this paper we consider the main properties of cylindrical lenses and propose several demonstrational experiments that can be performed with them. Specifically we use simple glasses full of water to demonstrate some basic geometrical optics principles and phenomena. We also present some less standard experiments that can be performed with such…

  4. A Demonstration on Every Exam.

    ERIC Educational Resources Information Center

    Julian, Glenn M.

    1995-01-01

    Argues that inclusion of demonstrations on examinations increases students' ability to observe carefully the physical world around them, translate from observation in terms of models, and make quantitative estimates and physicist-type "back-of-the-envelope" calculations. Presents demonstration ideas covering the following topics: mechanics,…

  5. A Demonstration of Sample Segregation

    ERIC Educational Resources Information Center

    Fritz, Mark D.; Brumbach, Stephen B.; Hartman, JudithAnn R.

    2005-01-01

    The demonstration of sample segregation, which is simple, and visually compelling illustrates the importance of sample handling for students studying analytical chemistry and environmental chemistry. The mixture used in this demonstration has two components, which have big particle size, and different colors, which makes the segregation graphic.

  6. Three Mechanical Demonstrations of Chaos.

    ERIC Educational Resources Information Center

    Ehrlich, Robert

    1990-01-01

    Describes three demonstrations showing chaotic motion, which makes long-term prediction impossible. Discusses the apparatus for the demonstrations and procedures for illustrating chaotic motion of pendulum, balls rolling in a double potential well, and a ball rolling on a balanced beam. (YP)

  7. The "Mushroom Cloud" Demonstration Revisited

    ERIC Educational Resources Information Center

    Panzarasa, Guido; Sparnacci, Katia

    2013-01-01

    A revisitation of the classical "mushroom cloud" demonstration is described. Instead of aniline and benzoyl peroxide, the proposed reaction involves household chemicals such as alpha-pinene (turpentine oil) and trichloroisocyanuric acid ("Trichlor") giving an impressive demonstration of oxidation and combustion reactions that…

  8. Understanding Statistics Using Computer Demonstrations

    ERIC Educational Resources Information Center

    Dunn, Peter K.

    2004-01-01

    This paper discusses programs that clarify some statistical ideas often discussed yet poorly understood by students. The programs adopt the approach of demonstrating what is happening, rather than using the computer to do the work for the students (and hide the understanding). The programs demonstrate normal probability plots, overfitting of…

  9. Demonstrating Allotropic Modifications of Sulfur.

    ERIC Educational Resources Information Center

    McCarty, Jillian L.; Dragojlovic, Veljko

    2002-01-01

    Shows how a common demonstration that consists of slowly heating sulfur powder in a test tube to illustrate sulfur's allotropic modifications can convince students of conclusions about the moon Io which they often find surprising. Describes the demonstration in full. (Author/MM)

  10. A Comprehensive General Chemistry Demonstration

    ERIC Educational Resources Information Center

    Sweeder, Ryan D.; Jeffery, Kathleen A.

    2013-01-01

    This article describes the use of a comprehensive demonstration suitable for a high school or first-year undergraduate introductory chemistry class. The demonstration involves placing a burning candle in a container adjacent to a beaker containing a basic solution with indicator. After adding a lid, the candle will extinguish and the produced…

  11. Measuring Impact of Demonstration Projects.

    ERIC Educational Resources Information Center

    Fleischman, Howard L.

    A proposed evaluation model for measuring the impact of demonstration projects in vocational education defines sets of criteria, standards, and documentation for both interim and final acceptable evidence of project impact. Interim acceptable evidence is that evidence of project success which should be expected during the demonstration grant…

  12. Rocket Ignition Demonstrations Using Silane

    NASA Technical Reports Server (NTRS)

    Pal, Sibtosh; Santoro, Robert; Watkins, William B.; Kincaid, Kevin

    1998-01-01

    Rocket ignition demonstration tests using silane were performed at the Penn State Combustion Research Laboratory. A heat sink combustor with one injection element was used with gaseous propellants. Mixtures of silane and hydrogen were used as fuel, and oxygen was used as oxidizer. Reliable ignition was demonstrated using fuel lead and and a swirl injection element.

  13. Tested Demonstrations: A Simple Demonstration of Reversible Oxygenation.

    ERIC Educational Resources Information Center

    Kildahl, Nicholas K.

    1983-01-01

    Materials needed, reaction involved, and potential hazards are provided for a demonstration of reversible oxygenation. Also discusses the importance of the reaction in biological systems, focusing on hemoglobin/myoglobin and their function in mammals. (JM)

  14. Buried Waste Integrated Demonstration: Selection of potential demonstration locations

    SciTech Connect

    Arrenholz, D.A.; Knight, J.L.

    1991-11-01

    The first step towards identifying primary Buried Waste Integrated Demonstration locations is the selection of potential demonstration sites within the Subsurface Disposal Area. The sites selected are Pits 4, 5, 6, and 9, containing transuranic waste of Rocky Flats origin, the Acid Pit, and Pad A. The criteria and methodology for selection of these sites, as well as a description of the wastes present in each area, are included in this report. At a later date, technology-specific demonstration locations will be selected from these six potential sites. The selected locations will be used as necessary to demonstrate technologies whose potential abilities may be optimal on waste forms present at these identified locations.

  15. Buried Waste Integrated Demonstration Strategy Plan

    SciTech Connect

    Kostelnik, K.M.

    1993-02-01

    The Buried Waste Integrated Demonstration (BWID) supports the applied research, development, demonstration, and evaluation of a suite of advanced technologies that form a comprehensive remediation system for the effective and efficient remediation of buried waste. These efforts are identified and coordinated in support of the US Department of Energy (DOE), Environmental Restoration and Waste Management (ERWM) needs and objectives. The present focus of BWID is to support retrieval and ex situ treatment configuration options. Future activities will explore and support containment and stabilization efforts in addition to the retrieval/ex situ treatment options. Long and short term strategies of the BWID are provided. Processes for identifying technological needs, screening candidate technologies for BWID applicability, researching technical issues, field demonstrating technologies, evaluating demonstration results to determine each technology`s threshold of capability, and commercializing successfully demonstrated technologies for implementation for environmental restoration also are presented in this report.

  16. Buried Waste Integrated Demonstration Strategy Plan

    SciTech Connect

    Kostelnik, K.M.

    1993-02-01

    The Buried Waste Integrated Demonstration (BWID) supports the applied research, development, demonstration, and evaluation of a suite of advanced technologies that form a comprehensive remediation system for the effective and efficient remediation of buried waste. These efforts are identified and coordinated in support of the US Department of Energy (DOE), Environmental Restoration and Waste Management (ERWM) needs and objectives. The present focus of BWID is to support retrieval and ex situ treatment configuration options. Future activities will explore and support containment and stabilization efforts in addition to the retrieval/ex situ treatment options. Long and short term strategies of the BWID are provided. Processes for identifying technological needs, screening candidate technologies for BWID applicability, researching technical issues, field demonstrating technologies, evaluating demonstration results to determine each technology's threshold of capability, and commercializing successfully demonstrated technologies for implementation for environmental restoration also are presented in this report.

  17. Resource Letter PhD-2: Physics Demonstrations

    NASA Astrophysics Data System (ADS)

    Berg, Richard E.

    2012-03-01

    This Resource Letter provides a guide to physics demonstrations, computer simulations of physics demonstrations, and physics education research regarding the use and effectiveness of demonstrations and simulations. Articles, books, and materials on the internet are cited for the following: professional journals dealing with demonstrations, web sites of professional organizations, workshops including use of demonstrations and simulations, books dealing with demonstrations in classroom teaching as well as informal settings, web sites for physics demonstrations, videos of physics demonstrations, demonstration simulations, and physics education research regarding the use of demonstrations in teaching.

  18. Buried Waste Integrated Demonstration test objectives

    SciTech Connect

    Morrison, J.L.; Heard, R.E.

    1993-05-01

    The mission of the Buried Waste Integrated Demonstration Program (BWID) is to support the development and demonstration of a suite of technologies that when integrated with commercially available baseline technologies form a comprehensive system for the effective and efficient remediation of buried waste throughout the US Department of Energy complex. To accomplish this mission of identifying technology solutions for remediation deficiencies, the Office of Technology Development initiated the BWID at the Idaho National Engineering Laboratory in fiscal year (FY) 1991. This document provides the test objectives against which the demonstrations will be tested during FY-93.

  19. Crafting a Gauss Gun Demonstration

    NASA Astrophysics Data System (ADS)

    Blodgett, Matthew E.; Blodgett, E. D.

    2006-12-01

    A Gauss Gun launches a ferromagnetic projectile using a pulsed electromagnet. This demonstration provides a nice counterpoint to the popular Thompson's jumping ring demonstration, which launches a nonferromagnetic ring via repulsion of an induced current. The pulsed current must be short enough in duration so that the projectile is not retarded by lingering current in the launch solenoid, but also large enough to provide a suitably impressive velocity. This project involved an iterative design process, as we worked through balancing all the different design criteria. We recommend it as a very nice electronics design project which will produce a very portable and enjoyable demonstration. AAPT sponsor Earl Blodgett.

  20. Optical Communications and Sensor Demonstration

    NASA Technical Reports Server (NTRS)

    Martinez, Andres; Petro, Andrew

    2015-01-01

    The Optical Communications and Sensor Demonstration (OCSD) project addresses two cross-cutting capabilities of value to many future small spacecraft missions: high-speed optical transmission of data and small spacecraft proximity operations. Optical data rates demonstrated by OCSD are expected to be 200 megabits persecond (Mbs) or higher, a factor of 100 increase over current high-end CubeSat communications systems. The proximity sensors developed for this mission enable relative position measurement between two small satellites - a capability not previously demonstrated.

  1. Notional Airspace Operations Demonstration Plan

    NASA Technical Reports Server (NTRS)

    Trongale, Nicholas A.

    2006-01-01

    The airspace operations demonstration (AOD) is intended to show that the Access 5 Step 1 functional requirements can be met. The demonstration will occur in two phases. The initial on-range phase will be carried out in restricted airspace to demonstrate the cooperative collision avoidance (CCA) functional requirements and to provide risk-reduction for the AOD by allowing the test team to rehearse some elements of the demonstration mission. The CCA system to be used in these flights is based on Automatic Dependent Surveillance-Broadcast (ADS-B) which is a commercially-available system by which airplanes constantly broadcast their current position and altitude to other aircraft and ground resources over a dedicated radio datalink. The final phase will occur in the national airspace (NAS) and will be the formal demonstration of the remainder of the proposed functional requirements. The general objectives of the AOD are as follows: (1) Demonstrate that the UAS can aviate in the NAS (2) Demonstrate that the UAS can navigate in the NAS (3) Demonstrate that the UAS can communicate with the NAS (4) Demonstrate that the UAS can perform selected collision avoidance functions in the NAS (5) Demonstrate that the UAS can evaluate and avoid weather conflicts in the NAS (6) Demonstrate that the UAS can provide adequate command and control in the NAS In addition to the stated objectives, there are a number of goals for the flight demonstration. The demo can be accomplished successfully without achieving these goals, but these goals are to be used as a guideline for preparing for the mission. The goals are: (1) Mission duration of at least 24 hours (2) Loiter over heavy traffic to evaluate the data block issue identified during the Access 5 Airspace Operations Simulations (3) Document the contingency management process and lessons learned (4) Document the coordination process for Ground Control Stations (GCS) handoff (5) Document lessons learned regarding the process of flying in

  2. New Adaptive Optics Technique Demonstrated

    NASA Astrophysics Data System (ADS)

    2007-03-01

    First ever Multi-Conjugate Adaptive Optics at the VLT Achieves First Light On the evening of 25 March 2007, the Multi-Conjugate Adaptive Optics Demonstrator (MAD) achieved First Light at the Visitor Focus of Melipal, the third Unit Telescope of the Very Large Telescope (VLT). MAD allowed the scientists to obtain images corrected for the blurring effect of atmospheric turbulence over the full 2x2 arcminute field of view. This world premiere shows the promises of a crucial technology for Extremely Large Telescopes. ESO PR Photo 19a/07 ESO PR Photo 19a/07 The MCAO Demonstrator Telescopes on the ground suffer from the blurring effect induced by atmospheric turbulence. This turbulence causes the stars to twinkle in a way which delights the poets but frustrates the astronomers, since it blurs the fine details of the images. However, with Adaptive Optics (AO) techniques, this major drawback can be overcome so that the telescope produces images that are as sharp as theoretically possible, i.e., approaching space conditions. Adaptive Optics systems work by means of a computer-controlled deformable mirror (DM) that counteracts the image distortion induced by atmospheric turbulence. It is based on real-time optical corrections computed from image data obtained by a 'wavefront sensor' (a special camera) at very high speed, many hundreds of times each second. The concept is not new. Already in 1989, the first Adaptive Optics system ever built for Astronomy (aptly named "COME-ON") was installed on the 3.6-m telescope at the ESO La Silla Observatory, as the early fruit of a highly successful continuing collaboration between ESO and French research institutes (ONERA and Observatoire de Paris). Ten years ago, ESO initiated an Adaptive Optics program to serve the needs for its frontline VLT project. Today, the Paranal Observatory is without any doubt one of the most advanced of its kind with respect to AO with no less than 7 systems currently installed (NACO, SINFONI, CRIRES and

  3. Cubesat Proximity Operations Demonstration (CPOD)

    NASA Technical Reports Server (NTRS)

    Villa, Marco; Martinez, Andres; Petro, Andrew

    2015-01-01

    The CubeSat Proximity Operations Demonstration (CPOD) project will demonstrate rendezvous, proximity operations and docking (RPOD) using two 3-unit (3U) CubeSats. Each CubeSat is a satellite with the dimensions 4 inches x 4 inches x 13 inches (10 centimeters x 10 centimeters x 33 centimeters) and weighing approximately 11 pounds (5 kilograms). This flight demonstration will validate and characterize many new miniature low-power proximity operations technologies applicable to future missions. This mission will advance the state of the art in nanosatellite attitude determination,navigation and control systems, in addition to demonstrating relative navigation capabilities.The two CPOD satellites are scheduled to be launched together to low-Earth orbit no earlier than Dec. 1, 2015.

  4. Status of the Majorana Demonstrator

    SciTech Connect

    Cuesta, C.; Abgrall, N.; Arnquist, I. J.; Avignone, III, F. T.; Barabash, A. S.; Bertrand, F. E.; Brudanin, V.; Busch, M.; Buuck, M.; Byram, D.; Caldwell, A. S.; Chan, Y. -D.; Christofferson, C. D.; Detwiler, J. A.; Efremenko, Yu.; Ejiri, H.; Elliott, S. R.; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Henning, R.; Hoppe, E. W.; Howard, S.; Howe, M. A.; Jasinski, B. R.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; LaFerriere, B. D.; Leon, J.; MacMullin, J.; Martin, R. D.; Meijer, S. J.; Mertens, S.; Orrell, J. L.; O'Shaughnessy, C.; Overman, N. R.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Rielage, K.; Robertson, R. G. H.; Romero-Romero, E.; Schmitt, C.; Shanks, B.; Shirchenko, M.; Snyder, N.; Suriano, A. M.; Tedeschi, D.; Timkin, V.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C. -H.; Yumatov, V.

    2015-08-06

    The Majorana Collaboration is constructing the Majorana Demonstrator, an ultra-low background, 40-kg modular high purity Ge detector array to search for neutrinoless double-beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based neutrinoless double-beta decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the Demonstrator is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. Lastly, the current status of the Demonstrator is discussed, as are plans for its completion.

  5. Status of the Majorana Demonstrator

    DOE PAGESBeta

    Cuesta, C.; Abgrall, N.; Arnquist, I. J.; Avignone, III, F. T.; Barabash, A. S.; Bertrand, F. E.; Brudanin, V.; Busch, M.; Buuck, M.; Byram, D.; et al

    2015-08-06

    The Majorana Collaboration is constructing the Majorana Demonstrator, an ultra-low background, 40-kg modular high purity Ge detector array to search for neutrinoless double-beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based neutrinoless double-beta decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the Demonstrator is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. Lastly, the current status of the Demonstrator is discussed, as are plans for its completion.

  6. CT Demonstration of Caput Medusae

    ERIC Educational Resources Information Center

    Weber, Edward C.; Vilensky, Joel A.

    2009-01-01

    Maximum intensity and volume rendered CT displays of caput medusae are provided to demonstrate both the anatomy and physiology of this portosystemic shunt associated with portal hypertension. (Contains 2 figures.)

  7. Classroom Demonstrations of Auditory Perception.

    ERIC Educational Resources Information Center

    Haws, LaDawn; Oppy, Brian J.

    2002-01-01

    Presents activities to help students gain understanding about auditory perception. Describes demonstrations that cover topics, such as sound localization, wave cancellation, frequency/pitch variation, and the influence of media on sound propagation. (CMK)

  8. Novel Third-Law Demonstration.

    ERIC Educational Resources Information Center

    Lonc, William

    1995-01-01

    Presents an easy method to demonstrate Third-Law interactions using identical button magnets sliding along a smooth (nonmagnetic) knitting needle. Explains the gravitational and magnetic interactions in the case of horizontal and vertical positions of the needle. (JRH)

  9. Demonstration of the Fenton Reaction

    ERIC Educational Resources Information Center

    Luehrs, Dean C.; Roher, Alex E.

    2007-01-01

    The study demonstrates the Fenton reaction, which is carried out using the Fenton reagent that is used for groundwater and soil remediation. The Fenton reaction can be implicated in DNA damage, Alzheimer's disease, cardiovascular disease and ageing in general.

  10. Demonstrating Forces between Parallel Wires.

    ERIC Educational Resources Information Center

    Baker, Blane

    2000-01-01

    Describes a physics demonstration that dramatically illustrates the mutual repulsion (attraction) between parallel conductors using insulated copper wire, wooden dowels, a high direct current power supply, electrical tape, and an overhead projector. (WRM)

  11. Status of the Majorana Demonstrator

    SciTech Connect

    Cuesta, C.; Abgrall, N.; Arnquist, Isaac J.; Avignone, Frank T.; Barabash, Alexander S.; Bertrand, F.; Brudanin, V.; Busch, Matthew; Buuck, M.; Byram, D.; Caldwell, A. S.; Chan, Yuen-Dat; Christofferson, Cabot-Ann; Detwiler, Jason A.; Efremenko, Yuri; Ejiri, H.; Elliott, S. R.; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, M. P.; Gruszko, J.; Guinn, I.; Guiseppe, V. E.; Henning, R.; Hoppe, Eric W.; Howard, Stanley; Howe, M. A.; Jasinski, B. R.; Keeter, K.; Kidd, M. F.; Konovalov, S.; Kouzes, Richard T.; Laferriere, Brian D.; Leon, Jonathan D.; MacMullin, J.; Martin, R. D.; Meijer, S. J.; Mertens, S.; Orrell, John L.; O'Shaughnessy, C.; Overman, Nicole R.; Poon, Alan; Radford, D. C.; Rager, J.; Rielage, Keith; Robertson, R. G. H.; Romero-Romero, E.; Schmitt, C.; Shanks, B.; Shirchenko, M.; Snyder, N.; Suriano, Anne-Marie; Tedeschi, D.; Timkin, V.; Trimble, J. E.; Varner, R. L.; Vasilyev, Sergey; Vetter, Kai; Vorren, Kris R.; White, Brandon R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, Chang-Hong; Yumatov, Vladimir

    2015-06-09

    The Majorana Collaboration is constructing the Majorana Demonstrator, an ultra-low background, 40-kg modular high purity Ge detector array to search for neutrinoless double-beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based neutrinoless double-beta decay searches that will probe the neutrino mass scale in the inverted hierarchy region, a major goal of the Demonstrator is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The current status of the Demonstrator is discussed, as are plans for its completion.

  12. Edison Demonstration of Smallsat Networks

    NASA Technical Reports Server (NTRS)

    Westley, Deborah; Martinez, Andres; Petro, Andrew

    2015-01-01

    The goal of NASA's Edison Demonstration of Smallsat Networks (EDSN) mission is to demonstrate interactive satellite swarms capable of collecting, exchanging and transmitting multi-point scientific measurements. Satellite swarms enable a wide array of scientific, commercial and academic research not achievable with a single satellite. The EDSN satellites are scheduled to be launched into space as secondary payloads on the first flight of the Super Strypi launch vehicle no earlier than Oct. 29, 2015.

  13. Lunar Water Resource Demonstration (LWRD)

    NASA Technical Reports Server (NTRS)

    Muscatello, Anthony C.

    2009-01-01

    Lunar Water Resource Demonstration (LWRD) is part of RESOLVE (Regolith and Environment Science & Oxygen and Lunar Volatile Extraction). RESOLVE is an ISRU ground demonstration: (1) A rover to explore a permanently shadowed crater at the south or north pole of the Moon (2) Drill core samples down to 1 meter (3) Heat the core samples to 150C (4) Analyze gases and capture water and/or hydrogen evolved (5) Use hydrogen reduction to extract oxygen from regolith

  14. Slant Borehole Demonstration Summary Report

    SciTech Connect

    GARDNER, M.G.

    2000-07-19

    This report provides a summary of the demonstration project for development of a slant borehole to retrieve soil samples from beneath the SX-108 single-shell tank. It provides a summary of the findings from the demonstration activities and recommendations for tool selection and methods to deploy into the SX Tank Farm. Daily work activities were recorded on Drilling and Sampling Daily Work Record Reports. The work described in this document was performed during March and April 2000.

  15. Yo-Yo Pull Demonstration

    ERIC Educational Resources Information Center

    Layton, William

    2013-01-01

    A popular demonstration involves placing a yo-yo on a level table and gently pulling the string horizontally when it is wrapped to come out below the center of the yo-yo's axis. Students are then asked to predict which way the yo-yo will move. A similar demonstration is performed with a tricycle by pulling forward on a pedal with the pedal down in…

  16. Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity

    PubMed Central

    Täubel, Jörg; Ferber, Georg; Lorch, Ulrike; Wang, Duolao; Sust, Mariano; Camm, A. John

    2015-01-01

    Background E-52862 is a Sigma-1 receptor antagonist (S1RA) currently under investigation as a potential analgesic medicine. We successfully applied a concentration-effect model retrospectively to a four-way crossover Phase I single ascending dose study and utilized the QTc shortening effects of a meal to demonstrate assay sensitivity by establishing the time course effects from baseline in all four periods, independently from any potential drug effects. Methods Thirty two healthy male and female subjects were included in four treatment periods to receive single ascending doses of 500 mg, 600 mg or 800 mg of E-52862 or placebo. PK was linear over the dose range investigated and doses up to 600 mg were well tolerated. The baseline electrocardiography (ECG) measurements on Day-1 were time-matched with ECG and pharmacokinetic (PK) samples on Day 1 (dosing day). Results In this conventional mean change to time-matched placebo analysis, the largest time-matched difference to placebo QTcI was 1.44 ms (90% CI: -4.04, 6.93 ms) for 500 mg; -0.39 ms (90% CI: -3.91, 3.13 ms) for 600 mg and 1.32 ms (90% CI: -1.89, 4.53 ms) for 800 mg of E-52862, thereby showing the absence of any QTc prolonging effect at the doses tested. In addition concentration-effect models, one based on the placebo corrected change from baseline and one for the change of QTcI from average baseline with time as fixed effect were fitted to the data confirming the results of the time course analysis. Conclusion The sensitivity of this study to detect small changes in the QTc interval was confirmed by demonstrating a shortening of QTcF of -8.1 (90% CI: -10.4, -5.9) one hour and -7.2 (90% CI: -9.4, -5.0) three hours after a standardised meal. Trial Registration EU Clinical Trials Register EudraCT 2010 020343 13 PMID:26291080

  17. Toms Creek IGCC Demonstration Project

    SciTech Connect

    Virr, M.J.

    1992-01-01

    The Toms Creek Integrated Gasification Combined Cycle (IGCC) Demonstration Project was selected by DOE in September 1991 to participate in Round Four of the Clean Coal Technology Demonstration Program. The project will demonstrate a simplified IGCC process consisting of an air-blown, fluidized-bed gasifier (Tampella U-Gas), a gas cooler/steam generator, and a hot gas cleanup system in combination with a gas turbine modified for use with a low-Btu content fuel and a conventional steam bottoming cycle. The demonstration plant will be located at the Toms Creek coal mine near Coeburn, Wise County, Virginia. Participants in the project are Tampella Power Corporation and Coastal Power Production Company. The plant will use 430 tons per day of locally mined bituminous coal to produce 55 MW of power from the gasification section of the project. A modern pulverized coal fired unit will be located adjacent to the Demonstration Project producing an additional 150 MW. A total 190 MW of power will be delivered to the electric grid at the completion of the project. In addition, 50,000 pounds per hour of steam will be exported to be used in the nearby coal preparation plant. Dolomite is used for in-bed gasifier sulfur capture and downs cleanup is accomplished in a fluidized-bed of regenerative zinc titanate. Particulate clean-up, before the gas turbine, will be performed by high temperature candle filters (1020[degree]F). The demonstration plant heat rate is estimated to be 8,700 Btu/kWh. The design of the project goes through mid 1995, with site construction activities commencing late in 1995 and leading to commissioning and start-up by the end of 1997. This is followed by a three year demonstration period.

  18. Toms Creek IGCC Demonstration Project

    SciTech Connect

    Virr, M.J.

    1992-11-01

    The Toms Creek Integrated Gasification Combined Cycle (IGCC) Demonstration Project was selected by DOE in September 1991 to participate in Round Four of the Clean Coal Technology Demonstration Program. The project will demonstrate a simplified IGCC process consisting of an air-blown, fluidized-bed gasifier (Tampella U-Gas), a gas cooler/steam generator, and a hot gas cleanup system in combination with a gas turbine modified for use with a low-Btu content fuel and a conventional steam bottoming cycle. The demonstration plant will be located at the Toms Creek coal mine near Coeburn, Wise County, Virginia. Participants in the project are Tampella Power Corporation and Coastal Power Production Company. The plant will use 430 tons per day of locally mined bituminous coal to produce 55 MW of power from the gasification section of the project. A modern pulverized coal fired unit will be located adjacent to the Demonstration Project producing an additional 150 MW. A total 190 MW of power will be delivered to the electric grid at the completion of the project. In addition, 50,000 pounds per hour of steam will be exported to be used in the nearby coal preparation plant. Dolomite is used for in-bed gasifier sulfur capture and downs cleanup is accomplished in a fluidized-bed of regenerative zinc titanate. Particulate clean-up, before the gas turbine, will be performed by high temperature candle filters (1020{degree}F). The demonstration plant heat rate is estimated to be 8,700 Btu/kWh. The design of the project goes through mid 1995, with site construction activities commencing late in 1995 and leading to commissioning and start-up by the end of 1997. This is followed by a three year demonstration period.

  19. Tested Demonstrations. Brownian Motion: A Classroom Demonstration and Student Experiment.

    ERIC Educational Resources Information Center

    Kirksey, H. Graden; Jones, Richard F.

    1988-01-01

    Shows how video recordings of the Brownian motion of tiny particles may be made. Describes a classroom demonstration and cites a reported experiment designed to show the random nature of Brownian motion. Suggests a student experiment to discover the distance a tiny particle travels as a function of time. (MVL)

  20. Demonstration Extension: Copper-to-Silver-to-Gold Penny Demonstration

    ERIC Educational Resources Information Center

    Vitz, Ed

    2008-01-01

    This demonstration, if done in the original way, can lead to fires in waste containers (sometimes in the middle of the night after the experiment has been conducted), because pyrophoric zinc is generated by suspending powdered zinc in hot sodium hydroxide. This is avoided by using hot ZnSO[subscript 4].