Science.gov

Sample records for dependent fluxes due

  1. Collisionality dependence of the quasilinear particle flux due to microinstabilities

    SciTech Connect

    Fueloep, T.; Pusztai, I.; Helander, P.

    2008-07-15

    The collisionality dependence of the quasilinear particle flux due to the ion temperature gradient (ITG) and trapped electron mode (TEM) instabilities is studied by including electron collisions modeled by a pitch-angle scattering collision operator in the gyrokinetic equation. The inward transport due to ITG modes is caused mainly by magnetic curvature and thermodiffusion and can be reversed as electron collisions are introduced, if the plasma is far from marginal stability. However, if the plasma is close to marginal stability, collisions may even enhance the inward transport. The sign and the magnitude of the transport are sensitive to the form of the collision operator, to the magnetic drift normalized to the real frequency of the mode, and to the density and temperature scale lengths. These analytical results are in agreement with previously published gyrokinetic simulations. Unlike the ITG-driven flux, the TEM-driven flux is expected to be outwards for conditions far from marginal stability and inwards otherwise.

  2. Temperature-dependent surface modification of Ta due to high-flux, low-energy He+ ion irradiation

    NASA Astrophysics Data System (ADS)

    Novakowski, T. J.; Tripathi, J. K.; Hassanein, A.

    2015-12-01

    This work examines the response of Tantalum (Ta) as a potential candidate for plasma-facing components (PFCs) in future nuclear fusion reactors. Tantalum samples were exposed to high-flux, low-energy He+ ion irradiation at different temperatures in the range of 823-1223 K. The samples were irradiated at normal incidence with 100 eV He+ ions at constant flux of 1.2 × 1021 ions m-2 s-1 to a total fluence of 4.3 × 1024 ions m-2. An additional Ta sample was also irradiated at 1023 K using a higher ion fluence of 1.7 × 1025 ions m-2 (at the same flux of 1.2 × 1021 ions m-2 s-1), to confirm the possibility of fuzz formation at higher fluence. This higher fluence was chosen to roughly correspond to the lower fluence threshold of fuzz formation in Tungsten (W). Surface morphology was characterized with a combination of field-emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). These results demonstrate that the main mode of surface damage is pinholes with an average size of ∼70 nm2 for all temperatures. However, significantly larger pinholes are observed at elevated temperatures (1123 and 1223 K) resulting from the agglomeration of smaller pinholes. Ex situ X-ray photoelectron spectroscopy (XPS) provides information about the oxidation characteristics of irradiated surfaces, showing minimal exfoliation of the irradiated Ta surface. Additionally, optical reflectivity measurements are performed to further characterize radiation damage on Ta samples, showing gradual reductions in the optical reflectivity as a function of temperature.

  3. Plasma flux-dependent lipid A deactivation

    NASA Astrophysics Data System (ADS)

    Chang, Hung-Wen; Hsu, Cheng-Che; Ahmed, Musahid; Liu, Suet Yi; Fang, Yigang; Seog, Joonil; Oehrlein, Gottlieb S.; Graves, David B.

    2014-06-01

    This paper reports the influence of gas plasma flux on endotoxin lipid A film deactivation. To study the effect of the flux magnitude of reactive species, a modified low-pressure inductively coupled plasma (ICP) with O radical flux ˜1016 cm-2 s-1 was used. After ICP exposures, it was observed that while the Fourier transform infrared absorbance of fatty chains responsible for the toxicity drops by 80% through the film, no obvious film endotoxin deactivation is seen. This is in contrast to that previously observed under low flux exposure conducted in a vacuum beam system: near-surface only loss of fatty chains led to significant film deactivation. Secondary ion mass spectrometry characterization of changes at the film surface did not appear to correlate with the degree of deactivation. Lipid A films need to be nearly completely removed in order to detect significant deactivation under high flux conditions. Additional high reactive species flux experiments were conducted using an atmospheric pressure helium plasma jet and a UV/ozone device. Exposure of lipid A films to reactive species with these devices showed similar deactivation behaviour. The causes for the difference between low and high flux exposures may be due to the nature of near-surface structural modifications as a function of the rate of film removal.

  4. Flux concentrations on solar dynamic components due to mispointing

    NASA Technical Reports Server (NTRS)

    Rylicki, Daniel S.

    1992-01-01

    Mispointing of the solar dynamic (SD) concentrator designed for use on Space Station Freedom (SSF) causes the optical axis of the concentrator to be nonparallel to the incoming rays from the Sun. This causes solar flux not to be focused into the aperture hole of the receiver and may position the flux on other SSF components. A Rocketdyne analysis has determined the thermal impact of off-axis radiation due to mispointing on elements of the SD module and photovoltaic (PV) arrays. The conclusion was that flux distributions on some of the radiator components, the two-axis gimbal rings, the truss, and the PV arrays could present problems. The OFFSET computer code was used at Lewis Research Center to further investigate these flux distributions incident on components. The Lewis study included distributions for a greater range of mispoint angles than the Rocketdyne study.

  5. Outward Poynting flux due to electromagnetic fluctuations in an RFP

    NASA Astrophysics Data System (ADS)

    Thuecks, D. J.; McCollam, K. J.; Stone, D. R.

    2013-10-01

    In a reversed-field pinch (RFP) driven by a toroidal electric field, tearing modes not only generate the net EMF that sustains the equilibrium profile but are also expected to produce an outward flow of electromagnetic energy, or Poynting flux, to be dissipated at the plasma edge. In MST experiments, insertable edge probes measure both electrostatic Ẽ and magnetic B~ fluctuations, which are used to reconstruct the flux-surface average Poynting flux < Ẽ × B~ > as it varies with minor radius, time, and equilibrium parameters. Our initial results indicate that this outward flux is a significant fraction of the total input power on time average and increases to large values during the brief periods surrounding discrete magnetic relaxation events, or sawtooth crashes. The flux decreases with radius outside of the reversal surface, suggesting that the electromagnetic energy is deposited there and dissipated into the plasma. These results are qualitatively similar to expectation from a simple model of an incompressible fluid plasma with a solid, resistive boundary. DOE and NSF support this work.

  6. Uncertainties Associated with Flux Measurements Due to Heterogeneous Contaminant Distributions

    EPA Science Inventory

    Mass flux and mass discharge measurements at contaminated sites have been applied to assist with remedial management, and can be divided into two broad categories: point-scale measurement techniques and pumping methods. Extrapolation across un-sampled space is necessary when usi...

  7. g Dependent particle concentration due to sedimentation

    NASA Astrophysics Data System (ADS)

    Haranas, Ioannis; Gkigkitzis, Ioannis; Zouganelis, George D.

    2012-11-01

    Sedimentation of particles in a fluid has long been used to characterize particle size distribution. Stokes' law is used to determine an unknown distribution of spherical particle sizes by measuring the time required for the particles to settle a known distance in a fluid of known viscosity and density. In this paper, we study the effects of gravity on sedimentation by examining the resulting particle concentration distributed in an equilibrium profile of concentration C m, n above the bottom of a container. This is for an experiment on the surface of the Earth and therefore the acceleration of gravity had been corrected for the oblateness of the Earth and its rotation. Next, at the orbital altitude of the spacecraft in orbit around Earth the acceleration due to the central field is corrected for the oblateness of the Earth. Our results show that for experiments taking place in circular or elliptical orbits of various inclinations around the Earth the concentration ratio C m, n / C m, ave , the inclination seems to be the most ineffective in affecting the concentration among all the orbital elements. For orbital experiment that use particles of diameter d p =0.001 μm the concentration ratios for circular and slightly elliptical orbits in the range e=0-0.1 exhibit a 0.009 % difference. The concentration ratio increases with the increase of eccentricity, which increases more for particles of larger diameters. Finally, for particles of the same diameter concentration ratios between Earth and Mars surface experiments are related in the following way C_{(m,n)_{mathit{Earth}}} = 0.99962 C_{(m,n)_{mathit{Mars}}}.

  8. Eddy-covariance flux errors due to biases in gas concentration measurements: origins, quantification and correction

    NASA Astrophysics Data System (ADS)

    Fratini, G.; McDermitt, D. K.; Papale, D.

    2013-08-01

    Errors in gas concentration measurements by infrared gas analysers can occur during eddy-covariance campaigns, associated with actual or apparent instrumental drifts or to biases due to thermal expansion, dirt contamination, aging of components or errors in field operations. If occurring on long time scales (hours to days), these errors are normally ignored during flux computation, under the assumption that errors in mean gas concentrations do not affect the estimation of turbulent fluctuations and, hence, of covariances. By analysing instrument theory of operation, and using numerical simulations and field data, we show that this is not the case for instruments with curvilinear calibrations; we further show that if not appropriately accounted for, concentration biases can lead to roughly proportional systematic flux errors, where the fractional errors in fluxes are about 30-40% the fractional errors in concentrations. We quantify these errors and characterize their dependency on main determinants. We then propose a correction procedure that largely - potentially completely - eliminates these errors. The correction, to be applied during flux computation, is based on knowledge of instrument calibration curves and on field or laboratory calibration data. Finally, we demonstrate the occurrence of such errors and validate the correction procedure by means of a field experiment, and accordingly provide recommendations for in situ operations. The correction described in this paper will soon be available in the EddyPro software (www.licor.com/eddypro).

  9. Test particle Monte Carlo simulation of return flux due to ambient scatter of outgassing molecules

    NASA Astrophysics Data System (ADS)

    Jin, Xuhong; Huang, Fei; Cheng, Xiaoli

    2014-12-01

    The return flux on circular disk surface due to ambient scatter of outgassing molecules is simulated by using the test particle Monte Carlo (TPMC) method. The return flux ratio (RFR) obtained here for the return flux problem is in good agreement with existent results. Moreover, some factors affecting the return flux, such as the radius and temperature of the circular disk and the freestream molecular mass, velocity, temperature and molecular number density, have been analyzed and the mechanism how they affect RFR has been discussed, which provide theoretical explanations for the evaluation and control of the return flux contamination.

  10. Spatial pattern dynamics due to the fitness gradient flux in evolutionary games.

    PubMed

    deForest, Russ; Belmonte, Andrew

    2013-06-01

    We introduce a nondiffusive spatial coupling term into the replicator equation of evolutionary game theory. The spatial flux is based on motion due to local gradients in the relative fitness of each strategy, providing a game-dependent alternative to diffusive coupling. We study numerically the development of patterns in one dimension (1D) for two-strategy games including the coordination game and the prisoner's dilemma, and in two dimensions (2D) for the rock-paper-scissors game. In 1D we observe modified traveling wave solutions in the presence of diffusion, and asymptotic attracting states under a frozen-strategy assumption without diffusion. In 2D we observe spiral formation and breakup in the frozen-strategy rock-paper-scissors game without diffusion. A change of variables appropriate to replicator dynamics is shown to correctly capture the 1D asymptotic steady state via a nonlinear diffusion equation. PMID:23848658

  11. Suppression of weak localization due to magnetic flux in few-channel ballistic microstructures

    SciTech Connect

    Pluhar, Z.; Weidenmueller, H.A.; Zuk, J.A. ); Lewenkopf, C.H. )

    1994-10-10

    Using a random-matrix model for the Hamiltonian of a ballistic microstructure, which is chaotic in the classical limit, maximizing the coupling to the external leads, and employing Landauer's formula and Efetov's supersymmetry technique, we derive an expression for the magnetic-flux dependence of weak localization. This expression describes the crossover from orthogonal to unitary symmetry, depends only on the number of channels and on the magnetic flux through the structure, and is expected to apply universally.

  12. Validation of neutron flux redistribution factors in JSI TRIGA reactor due to control rod movements.

    PubMed

    Kaiba, Tanja; Žerovnik, Gašper; Jazbec, Anže; Štancar, Žiga; Barbot, Loïc; Fourmentel, Damien; Snoj, Luka

    2015-10-01

    For efficient utilization of research reactors, such as TRIGA Mark II reactor in Ljubljana, it is important to know neutron flux distribution in the reactor as accurately as possible. The focus of this study is on the neutron flux redistributions due to control rod movements. For analyzing neutron flux redistributions, Monte Carlo calculations of fission rate distributions with the JSI TRIGA reactor model at different control rod configurations have been performed. Sensitivity of the detector response due to control rod movement have been studied. Optimal radial and axial positions of the detector have been determined. Measurements of the axial neutron flux distribution using the CEA manufactured fission chambers have been performed. The experiments at different control rod positions were conducted and compared with the MCNP calculations for a fixed detector axial position. In the future, simultaneous on-line measurements with multiple fission chambers will be performed inside the reactor core for a more accurate on-line power monitoring system. PMID:26141293

  13. Heat flux due to poloidal electric field in the banana regime

    SciTech Connect

    Taguchi, M. )

    1992-02-01

    The heat flux due to poloidally varying electrostatic potential is calculated in the banana regime. This electrostatic potential determined self-consistently from charge neutrality is shown to increase the electron heat flux by a factor {radical}{ital m}{sub {ital i}}/{ital m}{sub {ital e}} compared with that when this potential is neglected, where {ital m}{sub {ital e}} and {ital m}{sub {ital i}} are the masses of electron and ion, respectively.

  14. Time-dependent modeling of solar wind acceleration from turbulent heating in open flux tubes

    NASA Astrophysics Data System (ADS)

    Woolsey, Lauren Nicole; Cranmer, Steven R.

    2015-04-01

    The acceleration of the solar wind, particularly from open flux tubes, remains an open question in solar physics. Countless physical processes have been suggested to explain all or parts of the coupled problem of coronal heating and wind acceleration, but the current generation of observations have been so far unable to distinguish which mechanism(s) dominates. In this project, we consider heating by Alfvén waves in a three-dimensional, time-dependent reduced magnetohydrodynamics model. This model solves for the heating rate as a function of time due to the twisting and braiding of magnetic field lines within a flux tube, which is caused by Alfvén waves generated at the single footpoint of the flux tube. We investigate three specific structures commonly found in the corona: 1) an open flux tube in a coronal hole, 2) an open flux tube on the edge of an equatorial streamer, and 3) an open flux tube directly neighboring an active region. We present the time-dependent heating rate, power spectra of fluctuations, and the time-averaged properties of the solar wind arising from each magnetic structure. We compare the time-averaged properties from the present modeling with previous results from a one-dimensional, time-steady code (Cranmer et al. 2007) to better calibrate the physics in the lower-dimensional code and get a better understanding of the intricate role that bursty, transient heating from Alfvén-wave-driven turbulence plays in the acceleration of the solar wind from different magnetic structures.

  15. The time dependence of reversed archeomagnetic flux patches

    NASA Astrophysics Data System (ADS)

    Terra-Nova, Filipe; Amit, Hagay; Hartmann, Gelvam A.; Trindade, Ricardo I. F.

    2015-02-01

    Archeomagnetic field models may provide important insights to the geodynamo. Here we investigate the existence and mobility of reversed flux patches (RFPs) in an archeomagnetic field model. We introduce topological algorithms to define, identify, and track RFPs. In addition, we explore the relations between RFPs and dipole changes and apply robustness tests to the RFPs. In contrast to previous definitions, patches that reside on the geographic equator are adequately identified based on our RFPs definition. Most RFPs exhibit a westward drift and migrate toward higher latitudes. Undulations of the magnetic equator and RFPs oppose the axial dipole moment (ADM). Filtered models show a tracking behavior similar to the nonfiltered model, and surprisingly new RFPs occasionally emerge. The advection and diffusion of RFPs have worked in unison to yield the decrease of the ADM at recent times. The absence of RFPs in the period 550-1440 A.D. is related to a low in intermediate degrees of the geomagnetic power spectrum. We thus hypothesize that the RFPs are strongly dependent on intermediate spherical harmonic degrees 4 and above.

  16. The time dependence of reversed archeomagnetic flux patches

    NASA Astrophysics Data System (ADS)

    Terra-Nova, Filipe; Amit, Hagay; Hartmann, Gelvam A.; Trindade, Ricardo I. F.

    2016-04-01

    Archeomagnetic field models may provide important insights to the geodynamo. Here we investigate the existence and mobility of reversed flux patches (RFPs) in archeomagnetic field model CALS3k.4b of Korte and Constable (2011; PEPI, 188, 247-259). We introduce topological algorithms to define, identify and track RPFs. In addition, we explore the relations between RFPs and dipole changes, and apply robustness tests to the RFPs. In contrast to previous definitions, patches that reside on the geographic equator are adequately identified based on our RFPs definition that takes the magnetic equator as a reference. Most RFPs exhibit a westward drift and migrate towards higher latitudes. Undulations of the magnetic equator and RFPs oppose the axial dipole moment (ADM). Filtered models show a tracking behaviour similar to the non-filtered model, and surprisingly new RFPs occasionally emerge. The advection and diffusion of RFPs have worked in unison to yield the decrease of the ADM at recent times. The absence of RFPs in the period 550-1440 AD is related to a low in intermediate degrees of the geomagnetic power spectrum. We thus hypothesize that the RFPs are strongly dependent on intermediate spherical harmonic degrees 4 and above. Comparison of tracking of RFPs among various archeomagnetic field models was also performed and gives more complex results.

  17. Forest Thinning Dramatically Enhances Ozone Flux due to Reactions With Elevated Emissions of Biogenic Hydrocarbons

    NASA Astrophysics Data System (ADS)

    Goldstein, A. H.; McKay, M.; Kurpius, M. R.; Schade, G. W.

    2003-12-01

    Forests are routinely managed for timber production and fire suppression by thinning and harvesting. The impact of these activities on biosphere-atmosphere exchange of reactive trace gases is profound, but has rarely been studied in the field. Here we present simultaneous observations of ozone and terpene fluxes before, during, and after pre-commercial thinning of a ponderosa pine plantation at Blodgett Forest (1300 m elevation on the western slope of the Sierra Nevada Mountains, CA). We previously reported that monoterpene emissions increased by an order of magnitude during and following forest thinning (Schade and Goldstein, GRL 2003). We also previously reported that half the daytime ozone flux to this ecosystem under normal summertime conditions (no disturbance) was due to gas-phase chemical loss, and we suggested that this ozone loss was occurring by reactions with biogenically emitted terpenes whose lifetime was short enough that they reacted before escaping the forest canopy (Kurpius and Goldstein, GRL 2003). Here we report that ozone loss was also dramatically enhanced during and following thinning, and we link these observations to confirm that the chemical ozone loss in the canopy was indeed due to reaction with biogenically emitted compounds whose emission was enhanced by disturbance. Based on the magnitudes of ozone flux due to chemical loss and the measured terpene fluxes, we infer that the emissions of previously undetected short-lived terpenes are approximately 15-20 times those of a-pinene during thinning, and 30-50 times those of a-pinene during summer and fall. Since a-pinene accounts for approximately 25% of the total monoterpenes we routinely measure with our automated in-situ GC instrumentation, we conclude that emissions of highly reactive terpenoid compounds could have been drastically under measured in previous field campaigns and that emissions of unidentified reactive terpenes could be 5-10 times larger than emissions of total terpenes

  18. Kilometric radiation power flux dependence on area of discrete aurora

    NASA Technical Reports Server (NTRS)

    Saflekos, N. A.; Burch, J. L.; Gurnett, D. A.; Anderson, R. R.; Sheehan, R. E.

    1989-01-01

    Kilometer wavelength radiation, measured from distant positions over the North Pole and over the Earth's equator, was compared to the area of discrete aurora imaged by several low-altitude spacecraft. Through correlative studies of auroral kilometric radiation (AKR) with about two thousand auroral images, a stereoscopic view of the average auroral acceleration region was obtained. A major result is that the total AKR power increases as the area of the discrete auroral oval increases. The implications are that the regions of parallel potentials or the auroral plasma cavities, in which AKR is generated, must possess the following attributes: (1) they are shallow in altitude and their radial position depends on wavelength, (2) they thread flux tubes of small cross section, (3) the generation mechanism in them reaches a saturation limit rapidly, and (4) their distribution over the discrete auroral oval is nearly uniform. The above statistical results are true for large samples collected over a long period of time (about six months). In the short term, AKR frequently exhibits temporal variations with scales as short as three minutes (the resolution of the averaged data used). These fluctuations are explainable by rapid quenchings as well as fast starts of the electron cyclotron maser mechanism. There were times when AKR was present at substantial power levels while optical emissions were below instrument thresholds. A recent theoretical result may account for this set of observations by predicting that suprathermal electrons, of energies as low as several hundred eV, can generate second harmonic AKR. The indirect observations of second harmonic AKR require that these electrons have mirror points high above the atmosphere so as to minimize auroral light emissions. The results provide evidence supporting the electron cyclotron maser mechanism.

  19. Net Fluorescein Flux Across Corneal Endothelium Strongly Suggests Fluid Transport is due to Electro-osmosis.

    PubMed

    Sanchez, J M; Cacace, V; Kusnier, C F; Nelson, R; Rubashkin, A A; Iserovich, P; Fischbarg, J

    2016-08-01

    We have presented prior evidence suggesting that fluid transport results from electro-osmosis at the intercellular junctions of the corneal endothelium. Such phenomenon ought to drag other extracellular solutes. We have investigated this using fluorescein-Na2 as an extracellular marker. We measured unidirectional fluxes across layers of cultured human corneal endothelial (HCE) cells. SV-40-transformed HCE layers were grown to confluence on permeable membrane inserts. The medium was DMEM with high glucose and no phenol red. Fluorescein-labeled medium was placed either on the basolateral or the apical side of the inserts; the other side carried unlabeled medium. The inserts were held in a CO2 incubator for 1 h (at 37 °C), after which the entire volume of the unlabeled side was collected. After that, label was placed on the opposite side, and the corresponding paired sample was collected after another hour. Fluorescein counts were determined with a (Photon Technology) DeltaScan fluorometer (excitation 380 nm; emission 550 nm; 2 nm bwth). Samples were read for 60 s. The cells utilized are known to transport fluid from the basolateral to the apical side, just as they do in vivo in several species. We used 4 inserts for influx and efflux (total: 20 1-h periods). We found a net flux of fluorescein from the basolateral to the apical side. The flux ratio was 1.104 ± 0.056. That difference was statistically significant (p = 0.00006, t test, paired samples). The endothelium has a definite restriction at the junctions. Hence, an asymmetry in unidirectional fluxes cannot arise from osmosis, and can only point instead to paracellular solvent drag. We suggest, once more, that such drag is due to electro-osmotic coupling at the paracellular junctions. PMID:26989056

  20. LYM2-dependent chitin perception limits molecular flux via plasmodesmata

    PubMed Central

    Faulkner, Christine; Petutschnig, Elena; Benitez-Alfonso, Yoselin; Beck, Martina; Robatzek, Silke; Lipka, Volker; Maule, Andrew J.

    2013-01-01

    Chitin acts as a pathogen-associated molecular pattern from fungal pathogens whose perception triggers a range of defense responses. We show that LYSIN MOTIF DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN 2 (LYM2), the Arabidopsis homolog of a rice chitin receptor-like protein, mediates a reduction in molecular flux via plasmodesmata in the presence of chitin. For this response, lym2-1 mutants are insensitive to the presence of chitin, but not to the flagellin derivative flg22. Surprisingly, the chitin-recognition receptor CHITIN ELCITOR RECEPTOR KINASE 1 (CERK1) is not required for chitin-induced changes to plasmodesmata flux, suggesting that there are at least two chitin-activated response pathways in Arabidopsis and that LYM2 is not required for CERK1-mediated chitin-triggered defense responses, indicating that these pathways are independent. In accordance with a role in the regulation of intercellular flux, LYM2 is resident at the plasma membrane and is enriched at plasmodesmata. Chitin-triggered regulation of molecular flux between cells is required for defense responses against the fungal pathogen Botrytis cinerea, and thus we conclude that the regulation of symplastic continuity and molecular flux between cells is a vital component of chitin-triggered immunity in Arabidopsis. PMID:23674687

  1. The evolution of future geogenic matter fluxes due Enhanced Weathering: Results from the Antwerp Experiment

    NASA Astrophysics Data System (ADS)

    Hartmann, Jens; Weiss, Andreas; Struyf, Eric; Schoelynck, Jonas; Meire, Patrick; Amann, Thorben

    2015-04-01

    Understanding the evolution of geogenic matter fluxes in soils due the application of rock products ontop of soils is relevant to evaluate alteration of soil solutions and saturation states of solutes. In the future the practice of applying rock products will continue and areas affected will likely spread (Hartmann et al., 2013). This trend will likely be fuelled by attempts to optimize carbon dioxide removal by increasing biomass production, soil organic carbon stocks, increase crop production or afforestation. All those efforts demand a certain amount of geogenic nutrients, which need to be replaced. To investigate the release patterns and the downward transport of an array of elements, and to study their fate as well as reaction processes, altered through this practice, a mesocosm experiment was established at Antwerp University. Extended results will be presented (c.f., Weiss et al., 2014) focusing on the release and transport of DIC (dissolved inorganic carbon) and Mg (magnesium) in the soil column downwards after the application of 22 kg m-2 olivine powder. Elevated DIC and Mg concentrations are detected in case of olivine is applied to mesocosms with wheat and barley, if compared to the mesocsoms without plants, and without olivine. The change patterns in concentrations and fluxes will be discussed. Hartmann, J., et al. (2013) Enhanced chemical weathering as a geoengineering strategy to reduce atmospheric carbon dioxide, supply nutrients, and mitigate ocean acidification. Reviews of Geophysics; 51(2), 113-149. doi: 10.1002/rog.20004 Weiss, A., et al. (2014) The overlooked compartment of the critical-zone-complex, considering the evolution of future geogenic matter fluxes: Agricultural topsoils. Procedia Earth and Planetary Science, 10, 339-342. doi:10.1016/j.proeps.2014.08.032

  2. MEASUREMENT OF RF LOSSES DUE TO TRAPPED FLUX IN A LARGE-GRAIN NIOBIUM CAVITY

    SciTech Connect

    Gianluigi Ciovati; Alex Gurevich

    2008-01-23

    Trapped magnetic field in superconducting niobium is a well known cause of radio-frequency (RF) residual losses. In this contribution, we present the results of RF tests on a single-cell cavity made of high-purity large grain niobium before and after allowing a fraction of the Earth magnetic field to be trapped in the cavity during the cooldown below the critical temperature Tc. This experiment has been done on the cavity before and after a low temperature baking. Temperature mapping allowed us to determine the location of hot-spots with high losses and to measure their field dependence. The results show not only an increase of the low-field residual resistance, but also a larger increase of the surface resistance for intermediate RF field (higher “medium field Q-slope”), which depends on the amount of the trapped flux. These additional field-dependent losses can be described as losses of pinned vortices oscillating under the applied RF magnetic field.

  3. MEASUREMENT OF RF LOSSES DUE TO TRAPPED FLUX IN A LARGE-GRAIN NIOBIUM CAVITY

    SciTech Connect

    Gianluigi Ciovati; Alex Gurevich

    2008-01-23

    Trapped magnetic field in superconducting niobium is a well known cause of radio-frequency (RF) residual losses. In this contribution, we present the results of RF tests on a single-cell cavity made of high-purity large grain niobium before and after allowing a fraction of the Earth’s magnetic field to be trapped in the cavity during the cooldown below the critical temperature Tc. This experiment has been done on the cavity before and after a low temperature baking. Temperature mapping allowed us to determine the location of hot-spots with high losses and to measure their field dependence. The results show not only an increase of the low-field residual resistance, but also a larger increase of the surface resistance for intermediate RF field (higher "medium field Qslope"), which depends on the amount of the trapped flux. These additional field-dependent losses can be described as losses of pinned vortices oscillating under the applied RF magnetic field.

  4. Soil organic carbon stocks and fluxes due to land use conversions at the European scale

    NASA Astrophysics Data System (ADS)

    Gobin, A.; Campling, P.

    2012-04-01

    (HOC) assimilated depends on the yields, as these directly relate to potential residue production, and on the prevailing climate with cold temperatures and dry moisture regimes being less favourable. Incorporating all crop residues into the soil results in HOC fluxes that range from 1.36 tonnes HOC/ha for oilseed and 1.14 tonnes HOC/ha for cereal to 0.54 tonnes/ha for sugar beet. The HOC fluxes drop to 0.69, 0.58 and 0.05 tonnes HOC/ha respectively when all residues are removed, e.g. for bio-energy purposes. Taking into account the projected areas for cereals (65 Mha), oilseed (10 Mha) and sugarbeet (2 Mha) in 2030, shows that residue management of cereals has a much larger impact on carbon fluxes to the agricultural soil than oilseed and sugar beet. The removal of all crop residues result in a lowering of soil organic carbon stocks, a reduction of humified organic carbon fluxes into the soil and an increase of carbon dioxide concentrations in the atmosphere. A significant minimum percentage of crop residues should be retained in the soils. Land management, land use changes and climate change have a significant influence on soil organic carbon stocks and fluxes across the EU-27. Determining the soil sequestration potential necessitates soil monitoring to provide evidence on the state of, and change, in agricultural soils, allowing to evaluate its effectiveness.

  5. Direction dependence of cosmological parameters due to cosmic hemispherical asymmetry

    NASA Astrophysics Data System (ADS)

    Mukherjee, Suvodip; Aluri, Pavan K.; Das, Santanu; Shaikh, Shabbir; Souradeep, Tarun

    2016-06-01

    Persistent evidence for a cosmic hemispherical asymmetry in the temperature field of cosmic microwave background (CMB) as observed by both WMAP as well as PLANCK increases the possibility of its cosmological origin. Presence of this signal may lead to different values for the standard model cosmological parameters in different directions, and that can have significant implications for other studies where they are used. We investigate the effect of this cosmic hemispherical asymmetry on cosmological parameters using non-isotropic Gaussian random simulations injected with both scale dependent and scale independent modulation strengths. Our analysis shows that As and ns are the most susceptible parameters to acquire position dependence across the sky for the kind of isotropy breaking phenomena under study. As expected, we find maximum variation arises for the case of scale independent modulation of CMB anisotropies. We find that scale dependent modulation profile as seen in PLANCK data could lead to only 1.25σ deviation in As in comparison to its estimate from isotropic CMB sky.

  6. Scale dependent climate change due to deforestation in Amazonia

    NASA Astrophysics Data System (ADS)

    Rauscher, Sara A.

    Numerous experiments were conducted with a regional climate model (MM5) to determine its ability to simulate the climate of tropical South America and to investigate the modeled climate's response to deforestation. Six month-long test simulations were performed for the wet (January) and dry seasons (July). MM5 was able to simulate the differences in regional circulation between the two seasons, and also reproduced the regional climate features of each month quite well. An evaluation of MM5's land surface model (OSULSM) showed that OSULSM does not partition energy at the surface correctly. The modeled sensible heat flux was far too high in comparison with observations. In order to mitigate this effect, soil layer depth, rooting depth, leaf area index, and initial soil moisture were increased. This configuration compared more favorably with observed data. Three experiments with 100% (DEF), 50% (PD1), and 20% (PD2) deforestation were performed for January and July. The partial deforestation experiments were designed to present a realistic picture of deforestation. The experiments showed that the model climate was more sensitive to land cover changes during the dry season. In addition, the response of the model to the imposed land cover changes was of the same or lesser magnitude than the difference between the wet and dry months for each season. In the January experiments, the area-averaged precipitation response was small. The July simulations showed a stronger response to the land cover changes, as precipitation decreased in all three experiments. The reduction in precipitation for each experiment was not proportional to the amount of deforestation: the decrease in precipitation for PD1 and PD2 was less than amount of deforestation relative to DEF, indicating that the amount and distribution of deforestation does have an impact on the climate signal. These simulations are sensitivity studies, and should not be interpreted as a forecast of the climatic effects of

  7. Thermodynamics of deposition flux-dependent intrinsic film stress

    PubMed Central

    Saedi, Amirmehdi; Rost, Marcel J.

    2016-01-01

    Vapour deposition on polycrystalline films can lead to extremely high levels of compressive stress, exceeding even the yield strength of the films. A significant part of this stress has a reversible nature: it disappears when the deposition is stopped and re-emerges on resumption. Although the debate on the underlying mechanism still continues, insertion of atoms into grain boundaries seems to be the most likely one. However, the required driving force has not been identified. To address the problem we analyse, here, the entire film system using thermodynamic arguments. We find that the observed, tremendous stress levels can be explained by the flux-induced entropic effects in the extremely dilute adatom gas on the surface. Our analysis justifies any adatom incorporation model, as it delivers the underlying thermodynamic driving force. Counterintuitively, we also show that the stress levels decrease, if the barrier(s) for adatoms to reach the grain boundaries are decreased. PMID:26888311

  8. Thermodynamics of deposition flux-dependent intrinsic film stress

    NASA Astrophysics Data System (ADS)

    Saedi, Amirmehdi; Rost, Marcel J.

    2016-02-01

    Vapour deposition on polycrystalline films can lead to extremely high levels of compressive stress, exceeding even the yield strength of the films. A significant part of this stress has a reversible nature: it disappears when the deposition is stopped and re-emerges on resumption. Although the debate on the underlying mechanism still continues, insertion of atoms into grain boundaries seems to be the most likely one. However, the required driving force has not been identified. To address the problem we analyse, here, the entire film system using thermodynamic arguments. We find that the observed, tremendous stress levels can be explained by the flux-induced entropic effects in the extremely dilute adatom gas on the surface. Our analysis justifies any adatom incorporation model, as it delivers the underlying thermodynamic driving force. Counterintuitively, we also show that the stress levels decrease, if the barrier(s) for adatoms to reach the grain boundaries are decreased.

  9. EFT for vortices with dilaton-dependent localized flux

    NASA Astrophysics Data System (ADS)

    Burgess, C. P.; Diener, Ross; Williams, M.

    2015-11-01

    We study how codimension-two objects like vortices back-react gravitationally with their environment in theories (such as 4D or higher-dimensional supergravity) where the bulk is described by a dilaton-Maxwell-Einstein system. We do so both in the full theory, for which the vortex is an explicit classical `fat brane' solution, and in the effective theory of `point branes' appropriate when the vortices are much smaller than the scales of interest for their back-reaction (such as the transverse Kaluza-Klein scale). We extend the standard Nambu-Goto description to include the physics of flux-localization wherein the ambient flux of the external Maxwell field becomes partially localized to the vortex, generalizing the results of a companion paper [4] from N=2 supergravity as the end-point of a hierarchical limit in which the Planck mass first and then the supersymmetry breaking scale are sent to infinity. We define, in the parent supergravity model, a new symplectic frame in which, in the rigid limit, manifest symplectic invariance is preserved and the electric and magnetic Fayet-Iliopoulos terms are fully originated from the dyonic components of the embedding tensor. The supergravity origin of several features of the resulting rigid supersymmetric theory are then elucidated, such as the presence of a traceless SU(2)- Lie algebra term in the Ward identity and the existence of a central charge in the supersymmetry algebra which manifests itself as a harmless gauge transformation on the gauge vectors of the rigid theory; we show that this effect can be interpreted as a kind of "superspace non-locality" which does not affect the rigid theory on space-time. To set the stage of our analysis we take the opportunity in this paper to provide and prove the relevant identities of the most general dyonic gauging of Special-Kaehler and Quaternionic-Kaehler isometries in a generic N=2 model, which include the supersymmetry Ward identity, in a fully symplectic-covariant formalism.

  10. Quantitative flux analysis reveals folate-dependent NADPH production

    NASA Astrophysics Data System (ADS)

    Fan, Jing; Ye, Jiangbin; Kamphorst, Jurre J.; Shlomi, Tomer; Thompson, Craig B.; Rabinowitz, Joshua D.

    2014-06-01

    ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidative pentose phosphate pathway, with malic enzyme sometimes also important. Although the relative contribution of glycolysis and oxidative phosphorylation to ATP production has been extensively analysed, similar analysis of NADPH metabolism has been lacking. Here we demonstrate the ability to directly track, by liquid chromatography-mass spectrometry, the passage of deuterium from labelled substrates into NADPH, and combine this approach with carbon labelling and mathematical modelling to measure NADPH fluxes. In proliferating cells, the largest contributor to cytosolic NADPH is the oxidative pentose phosphate pathway. Surprisingly, a nearly comparable contribution comes from serine-driven one-carbon metabolism, in which oxidation of methylene tetrahydrofolate to 10-formyl-tetrahydrofolate is coupled to reduction of NADP+ to NADPH. Moreover, tracing of mitochondrial one-carbon metabolism revealed complete oxidation of 10-formyl-tetrahydrofolate to make NADPH. As folate metabolism has not previously been considered an NADPH producer, confirmation of its functional significance was undertaken through knockdown of methylenetetrahydrofolate dehydrogenase (MTHFD) genes. Depletion of either the cytosolic or mitochondrial MTHFD isozyme resulted in decreased cellular NADPH/NADP+ and reduced/oxidized glutathione ratios (GSH/GSSG) and increased cell sensitivity to oxidative stress. Thus, although the importance of folate metabolism for proliferating cells has been long recognized and attributed to its function of producing one-carbon units for nucleic acid synthesis, another crucial function of this pathway is generating reducing power.

  11. Estimation of surface temperature variations due to changes in sky and solar flux with elevation.

    USGS Publications Warehouse

    Hummer-Miller, S.

    1981-01-01

    Sky and solar radiance are of major importance in determining the ground temperature. Knowledge of their behavior is a fundamental part of surface temperature models. These 2 fluxes vary with elevation and this variation produces temperature changes. Therefore, when using thermal-property differences to discriminate geologic materials, these flux variations with elevation need to be considered. -from Author

  12. Flux noise due to magnetic impurities in superconducting circuits: Optimal spin texture and role of phase transition

    NASA Astrophysics Data System (ADS)

    de Sousa, Rogério

    Superconducting quantum interference devices (SQUIDs) and other superconducting circuits are limited by intrinsic flux noise with spectral density 1 /fα with α < 1 whose origin is believed to be due to spin impurities. We present a theory of flux noise in the presence of phase transitions and arbitrary spin textures in the impurity spin system. At higher temperatures we find that the spin-spin correlation length scale (describing, e.g., the average size of ferromagnetic spin clusters) greatly impacts the scaling of flux noise with wire geometry. At lower temperatures we find that flux noise is quite sensitive to the particular spin texture realized by the spin system ground state. Remarkably, we show that flux-noise is exactly equal to zero when the spins form a poloidal texture. Flux noise is nonzero for other spin textures, but gets reduced in the presence of correlated ferromagnetic fluctuations between the top and bottom wire surfaces, where the flux vectors are antiparallel. This demonstrates the idea of engineering spin textures and/or intersurface correlation as a method to reduce flux noise in superconducting circuits. This research was supported by the Natural Sciences and Engineering Research Council of Canada (RGPIN/342982-2010, EGP/429649-2012) through its Discovery and Engage programs.

  13. Evidence for a possible calcium flux dependent cardiomyopathy in hyperthyroidism

    SciTech Connect

    Barat, J.L.; Wicker, P.; Manley, W.; Brendel, A.J.; Lefort, G.; San Galli, F.; Commenges-Ducos, M.; Latapie, J.L.; Riviere, J.; Ducassou, D.

    1985-05-01

    This study was designed to test the hypothesis that the impaired functional cardiac reserve to exercise in hyperthyroidism is related to alterations in the regulation of calcium transport. In 2l hyperthyroid patients, the left ventricular ejection fraction (LVEF) was measured using equilibrium gated radionuclide angiocardiography at rest and during supine dynamic exercise. After a recovery period, the patients performed a second exercise study after random administration of Verapamil, a calcium entry blocker (11 pts), or propanolol, a beta adrenergic antagonist (10 pts) for comparison. The results showed i) normal resting LVEF with no significant change during exercise before any medication, ii) resting LVEF significantly decreased after Propanolol, and no significantly changed after Verapamil, iii) during exercise, significant increase of LVEF after Verapamil, and no significant change after Propanolol. These results are consistent with previous studies showing that abnormal change in LVEF during exercise in hyperthyroidism seems independent of beta adrenergic activation, and suggest a reversible functional cardiomyopathy dependent of calcium transporting systems.

  14. Fast stratocumulus adjustment timescale due to entrainment-liquid flux feedback

    NASA Astrophysics Data System (ADS)

    Jones, C. R.; Bretherton, C. S.; Blossey, P. N.

    2013-12-01

    We use a mixed-layer model (MLM) and large eddy simulation (LES) to analyze the response timescales of a stratocumulus-topped boundary layer. From the MLM, we find three separate time scales: a slow adjustment timescale associated with boundary layer deepening (on the order of several days); an intermediate timescale associated with thermodynamic adjustment of the boundary layer (approximately one day); and a fast timescale (6-12 hours) associated with entrainment rate feedbacks. We show that the fast scale is due to entrainment-liquid flux (ELF) adjustment, an internal cloud-regulating feedback between entrainment rate and the cloud liquid water path (LWP). A thicker cloud generates more turbulent kinetic energy and an increased entrainment rate which tends to warm and dry the boundary layer, thereby decreasing the cloud thickness (a negative feedback). Through this mechanism, the cloud base quickly adjusts until the entrainment rate and LWP stabilize as entrainment warming balances boundary-layer radiative cooling. We use two cases based on past model intercomparison studies to investigate the fast time scale. The first (DYCOMS RF01) involves a nocturnal stratocumulus-capped mixed layer with idealized radiative forcing. A perturbation to the free tropospheric relative humidity is shown to induce fast adjustment of cloud thickness in the MLM and also in an LES. A second case with realistic radiation used in past for cloud feedback studies (CGILS S12) is used to show that an instantaneous CO2 increase does not elicit a fast response in cloud thickness. However, an instantaneous temperature increase to the whole atmosphere-ocean column induces a cloud thinning with a few hours in both MLM and LES that largely explains the equilibrium response of the cloud layer to this forcing. This fast ELF adjustment suggests that stratocumulus cloud changes likely have a positive feedback on greenhouse warming.

  15. Energy dependence of relativistic electron flux variations in the outer radiation belt during geomagnetic storms

    NASA Astrophysics Data System (ADS)

    Xiong, Ying; Xie, Lun; Li, Jinxing; Fu, Suiyan; Pu, Zuyin; Chen, Lunjin; Ni, Binbin; Li, Wen

    2015-04-01

    Geomagnetic storms can either increase or decrease relativistic electron fluxes in the outer radiation belt, depending on the delicate competition between electron energization and loss processes. Despite the well-known "energy independent" prototype in which electron fluxes enhance after geomagnetic storms at all energies, we present observations of "energy dependent" events, i.e., post-storm electron fluxes at lower energies (0.3-2.5 MeV, measured by MEPED/POES) recover or even exceed the pre-storm level, while electron fluxes at higher energies (2.5-14 MeV, measured by PET/SAMPEX) do not restore. The statistical survey of 84 isolated storms demonstrates that geomagnetic storms preferentially decrease relativistic electron fluxes at higher energies while flux enhancements are more common at lower energies: ~ 82% (3%) storm events produce increased (decreased) flux for 0.3-2.5 MeV electrons, while ~ 37% (45%) storms lead to enhancements (reductions) of 2.5-14 MeV electron flux. Superposed epoch analysis suggests that "energy dependent" events preferentially occur during periods of high solar wind density along with high dynamic pressure. Previous statistical studies have shown that this kind of solar wind conditions account for significant enhancements of EMIC waves, which cause efficient precipitation of > 2 MeV electrons into atmosphere via pitch angle scattering. Two cases of "energy dependent" events are investigated in detail with evident observations of EMIC waves that can resonate effectively with >2 MeV electrons. Besides, we do not capture much differences in the chorus wave activity between those "energy dependent" and "energy independent" events. Therefore, our results strongly suggest that EMIC waves play a crucial role in the occurrences of those "energy dependent" events in the outer zone during geomagnetic storms.

  16. Energy Dependent Responses of Relativistic Electron Fluxes in the Outer Radiation Belt to Geomagnetic Storms

    NASA Astrophysics Data System (ADS)

    Xie, L.

    2015-12-01

    Geomagnetic storms can either increase 4 or decrease relativistic electron fluxes in the outer radiation belt. A statistical survey of 84 isolated storms demonstrates that geomagnetic storms preferentially decrease relativistic electron fluxes at higher energies while flux enhancements are more common at lower energies. In about 87% of the storms, 0.3-2.5 MeV electrons fluxes show increase, whereas 2.5-14 MeV electron fluxes increase in only 35% of the storms. Superposed epoch analyses suggest that such 'energy dependent' behavior of electrons preferably occurs during conditions of high solar wind density which is favorable to generate magnetospheric electromagnetic ion cyclotron (EMIC) waves and these 'energy dependent' events are associated with relatively weaker chorus activities. We have examined one of the cases where observed EMIC waves can resonate effectively with >2.5 MeV electrons and scatter them into the atmosphere. The correlation study further illustrates that electron flux drop-outs during storm main phases do not correlate well with the flux build-up during storm recovery phases. We suggest that a combination of efficient EMIC-induced scattering and weaker chorus-driven acceleration provide a viable candidate for the energy dependent responses of outer radiation belt relativistic electrons to geomagnetic storms. These results are of great interest to both understanding of the radiation belt dynamics and applications in space weather.

  17. Self-Regulated Plasma Heat Flux Mitigation Due to Liquid Sn Vapor Shielding.

    PubMed

    van Eden, G G; Morgan, T W; Aussems, D U B; van den Berg, M A; Bystrov, K; van de Sanden, M C M

    2016-04-01

    A steady-state high-flux H or He plasma beam was balanced against the pressure of a Sn vapor cloud for the first time, resulting in a self-regulated heat flux intensity near the liquid surface. A temperature response of the liquid surface characterized by a decoupling from the received heating power and significant cooling of the plasma in the neutral Sn cloud were observed. The plasma heat flux impinging on the target was found to be mitigated, as heat was partially dissipated by volumetric processes in the vapor cloud rather than wholly by surface effects. These results motivate further exploration of liquid metal solutions to the critical challenge of heat and particle flux handling in fusion power plants. PMID:27081983

  18. Self-Regulated Plasma Heat Flux Mitigation Due to Liquid Sn Vapor Shielding

    NASA Astrophysics Data System (ADS)

    van Eden, G. G.; Morgan, T. W.; Aussems, D. U. B.; van den Berg, M. A.; Bystrov, K.; van de Sanden, M. C. M.

    2016-04-01

    A steady-state high-flux H or He plasma beam was balanced against the pressure of a Sn vapor cloud for the first time, resulting in a self-regulated heat flux intensity near the liquid surface. A temperature response of the liquid surface characterized by a decoupling from the received heating power and significant cooling of the plasma in the neutral Sn cloud were observed. The plasma heat flux impinging on the target was found to be mitigated, as heat was partially dissipated by volumetric processes in the vapor cloud rather than wholly by surface effects. These results motivate further exploration of liquid metal solutions to the critical challenge of heat and particle flux handling in fusion power plants.

  19. A case study of electron precipitation fluxes due to plasmaspheric hiss

    NASA Astrophysics Data System (ADS)

    Hardman, Rachael; Clilverd, Mark A.; Rodger, Craig J.; Brundell, James B.; Duthie, Roger; Holzworth, Robert H.; Mann, Ian R.; Milling, David K.; Macusova, Eva

    2015-08-01

    We find that during a large geomagnetic storm in October 2011 the trapped fluxes of >30, >100, and >300 keV outer radiation belt electrons were enhanced at L = 3-4 during the storm main phase. A gradual decay of the trapped fluxes was observed over the following 5-7 days, even though no significant precipitation fluxes could be observed in the Polar Orbiting Environmental Satellite (POES) electron precipitation detectors. We use the Antarctic-Arctic Radiation-belt (Dynamic) Deposition-VLF Atmospheric Research Konsortium receiver network to investigate the characteristics of the electron precipitation throughout the storm period. Weak electron precipitation was observed on the dayside for 5-7 days, consistent with being driven by plasmaspheric hiss. Using a previously published plasmaspheric hiss-induced electron energy e-folding spectrum of E0 = 365 keV, the observed radio wave perturbation levels at L = 3-4 were found to be caused by >30 keV electron precipitation with flux ~100 el cm-2 s-1 sr-1. The low levels of precipitation explain the lack of response of the POES telescopes to the flux, because of the effect of the POES lower sensitivity limit and ability to measure weak diffusion-driven precipitation. The detection of dayside, inner plasmasphere electron precipitation during the recovery phase of the storm is consistent with plasmaspheric hiss wave-particle interactions and shows that the waves can be a significant influence on the evolution of the outer radiation belt trapped flux that resides inside the plasmapause.

  20. Artificial neural network prediction model for geosynchronous electron fluxes: Dependence on satellite position and particle energy

    NASA Astrophysics Data System (ADS)

    Shin, Dae-Kyu; Lee, Dae-Young; Kim, Kyung-Chan; Hwang, Junga; Kim, Jaehun

    2016-04-01

    Geosynchronous satellites are often exposed to energetic electrons, the flux of which varies often to a large extent. Since the electrons can cause irreparable damage to the satellites, efforts to develop electron flux prediction models have long been made until recently. In this study, we adopt a neural network scheme to construct a prediction model for the geosynchronous electron flux in a wide energy range (40 keV to >2 MeV) and at a high time resolution (as based on 5 min resolution data). As the model inputs, we take the solar wind variables, geomagnetic indices, and geosynchronous electron fluxes themselves. We also take into account the magnetic local time (MLT) dependence of the geosynchronous electron fluxes. We use the electron data from two geosynchronous satellites, GOES 13 and 15, and apply the same neural network scheme separately to each of the GOES satellite data. We focus on the dependence of prediction capability on satellite's magnetic latitude and MLT as well as particle energy. Our model prediction works less efficiently for magnetic latitudes more away from the equator (thus for GOES 13 than for GOES 15) and for MLTs nearer to midnight than noon. The magnetic latitude dependence is most significant for an intermediate energy range (a few hundreds of keV), and the MLT dependence is largest for the lowest energy (40 keV). We interpret this based on degree of variance in the electron fluxes, which depends on magnetic latitude and MLT at geosynchronous orbit as well as particle energy. We demonstrate how substorms affect the flux variance.

  1. Intensity of Upward Muon Flux Due to Cosmic-Ray Neutrinos Produced in the Atmosphere

    DOE R&D Accomplishments Database

    Lee, T. D.; Robinson, H.; Schwartz, M.; Cool, R.

    1963-06-01

    Calculations were performed to determine the upward going muon flux leaving the earth's surface after production by cosmic-ray neutrinos in the crust. Only neutrinos produced in the earth's atmosphere are considered. Rates of the order of one per 100 sq m/day might be expected if an intermediate boson exists and has a mass less than 2 Bev. (auth)

  2. The seasonal dependence of relativistic electron fluxes in the Earth's outer van Allen Belt

    NASA Astrophysics Data System (ADS)

    Kanekal, S. G.; Baker, D. N.; McPherron, R.

    2007-12-01

    It is well known that geomagnetic activity shows a marked seasonal dependence. This effect has been attributed to the seasonal variation of the Earth's dipole tilt angle exposing the magnetosphere to an increased southward component of the interplanetary field (the Russell-McPherron effect) or an increased solar wind velocity (the axial/equinoctial effect). We examine the seasonal dependence of relativistic electron fluxes in the Earth's outer Van Allen belt. An earlier investigation by Baker et. al., (1999) found that the relativistic electron fluxes do show a strong seasonal dependence with the equinoctial electron fluxes being almost three times higher than the solstitial fluxes. We extend this previous investigation using data obtained by sensors onboard SAMPEX. This study of the seasonal dependence is based on data with a higher time resolution as compared to the earlier study. The results of our analysis show that the peak electron fluxes are shifted in time from the nominal equinoctial times. We discuss some possible implications of our observations in the context of electron energization in the Earth's magnetosphere. Baker, D.N., S.G. Kanekal, T.I. Pulkkinen, and J.B. Blake, Equinoctial and solstitial averages of magnetospheric relativistic electrons: A strong semiannual modulation, Geophys. Res. Lett., 26, No. 20, 3193-3196, 1999.

  3. Temperature dependent surface modification of molybdenum due to low energy He+ ion irradiation

    NASA Astrophysics Data System (ADS)

    Tripathi, J. K.; Novakowski, T. J.; Joseph, G.; Linke, J.; Hassanein, A.

    2015-09-01

    In this paper, we report on the temperature dependent surface modifications in molybdenum (Mo) samples due to 100 eV He+ ion irradiation in extreme conditions as a potential candidate to plasma-facing components in fusion devices alternative to tungsten. The Mo samples were irradiated at normal incidence, using an ion fluence of 2.6 × 1024 ions m-2 (with a flux of 7.2 × 1020 ions m-2 s-1). Surface modifications have been studied using high-resolution field emission scanning electron-(SEM) and atomic force (AFM) microscopy. At 773 K target temperature homogeneous evolution of molybdenum nanograins on the entire Mo surface were observed. However, at 823 K target temperature appearance of nano-pores and pin-holes nearby the grain boundaries, and Mo fuzz in patches were observed. The fuzz density increases significantly with target temperatures and continued until 973 K. However, at target temperatures beyond 973 K, counterintuitively, a sequential reduction in the fuzz density has been seen till 1073 K temperatures. At 1173 K and above temperatures, only molybdenum nano structures were observed. Our temperature dependent studies confirm a clear temperature widow, 823-1073 K, for Mo fuzz formation. Ex-situ high resolution X-ray photoelectron spectroscopy studies on Mo fuzzy samples show the evidence of MoO3 3d doublets. This elucidates that almost all the Mo fuzz were oxidized during open air exposure and are thick enough as well. Likewise the microscopy studies, the optical reflectivity measurements also show a sequential reduction in the reflectivity values (i.e., enhancement in the fuzz density) up to 973 K and after then a sequential enhancement in the reflectivity values (i.e., reduction in the fuzz density) with target temperatures. This is in well agreement with microscopy studies where we observed clear temperature window for Mo fuzz growth.

  4. The thermal dependence of Na+ flux in isolated liver cells from ectotherms and endotherms.

    PubMed

    Else, Paul L

    2016-07-15

    The thermal dependence (0-40°C) of Na(+) flux in isolated liver cells of three endotherms (mice, rat and rabbit) was compared with that of ectotherms in the form of a thermally tolerant amphibian (cane toad), a cold-water fish (rainbow trout) and a thermophilic reptile (lizard). Mammals were found to share similar high rates of Na(+) flux (3.0-3.7 nmol Na(+) mg(-1) protein min(-1)) at their normal body temperatures (36-39°C). These Na(+) flux rates were significantly greater (P<0.0004-0.0001) than those of the ectotherms, which shared similar low rates of Na(+) flux (0.7-1.3 nmol Na(+) mg(-1) protein min(-1)) at their very different normal acclimated body temperatures (15°C for trout, 25°C for toad and 37°C for the lizard species). Trout, which possess highly unsaturated membranes (similar to those of mammals), showed a Na(+) flux with high thermal sensitivity at low temperatures similar to that found in mammals at higher temperatures. The thermal sensitivity of toad Na(+) flux was significantly less (P<0.05-0.01) than that of rat and rabbit. Trout Na(+) flux did not increase with increasing temperature much above 20°C, whereas all other species measured increased their Na(+) flux with increasing temperature up to 40°C. In conclusion, at normal operating body temperatures, the rate of Na(+) flux is much lower in ectotherms. PMID:27207635

  5. Dependence of Large-Scale Global Poynting Flux on IMF By Polarity Change

    NASA Astrophysics Data System (ADS)

    Humberset, B. K.; Gjerloev, J. W.

    2014-12-01

    In this study we present the dependence of the global Poynting flux on the IMF By polarity change. The amount of energy that enters the magnetosphere from the solar wind is a function of the solar wind speed and pressure and the IMF orientation and magnitude. All the various published coupling models show that the polarity of the IMF By component does not change the energy input. In contrast the global convection patterns, and thus the ionospheric Pedersen currents, depend on IMF By polarity. This seems to imply that the ionospheric energy deposition is a function of IMF By polarity. Thus, there appear to be a fundamental difference between the input (from the solar wind) and the output (energy dissipating Pedersen currents). We, therefore, ask the question: To what extend is the global Poynting flux dependent on the IMF By polarity? We have performed a statistical study evaluating 59 abrupt transitions in the IMF By component (polarity changes) as measured by the ACE spacecraft. The effect of other solar wind coupling parameters, such as the IMF Bz component, are minimized by selecting events where these are nearly constant. We use electric field distributions from SuperDARN and field-aligned current distributions from AMPERE to calculate the global distribution of the Poynting Flux. To minimize the effect of magnetospheric energy unloading we focus on the 06-18 MLT region. We further investigate the dependence on solar induced conductivity. We find that the Poynting flux is slightly larger for positive IMF By compared to negative By conditions. For a low conductivity (not sunlit) ionosphere the Poynting flux is smaller than in the high conductivity (sunlit) ionosphere and we find a smaller dependence on IMF By polarity. The study emphasizes the global dynamic behavior of the ionosphere in its response to changes in the external driver (IMF).

  6. Apparent drifts of IRGA measurements due to optical path contamination and their effects on eddy-covariance fluxes

    NASA Astrophysics Data System (ADS)

    McDermitt, D. K.; Fratini, G.; Papale, D.

    2013-12-01

    Apparent instrumental biases can cause errors in gas concentration measurements by infrared gas analysers (IRGAs) used in eddy-covariance flux measurements. Such biases most often result from deposition of atmospheric pollutants, such as aerosols, pollen, or particulate matter on surfaces in the optical path, which in some cases, can cause differential signal attenuation in the sample and reference channels of the gas analyser. We refer to such biases as apparent, to stress that they are not the result of an intrinsic loss of instrumental metric performance, but rather of incidental and avoidable deployment artefacts. Nonetheless, due to the curvilinear nature of IRGAs calibration curves, they can cause errors in eddy-covariance fluxes, resulting from reduced accuracy of the gas concentration measurement. In this work we describe the phenomenological and mathematical foundations of these concentration biases, also showing how measurements from different IRGA typologies are affected as a result. By means of numerical simulations, we find that concentration biases can lead to roughly proportional systematic flux errors, where the fractional errors in fluxes are roughly 30-40% the fractional errors in concentrations. We also propose a correction procedure and provide recommendations for field deployment and operation, to minimize or completely eliminate such errors. The correction procedure will soon be available in the EddyPro software (www.licor.com/eddypro).

  7. Angular dependences of the motion of the anisotropic flux line lattice and the peak effect in MgB2

    NASA Astrophysics Data System (ADS)

    Jang, D.-J.; Lee, H.-S.; Kang, B.; Lee, H.-G.; Cho, M.-H.; Lee, S.-I.

    2008-12-01

    We have studied the angle-dependent motion of the anisotropic flux line lattice (FLL) and the peak effect (PE) in MgB2 single crystals. For arbitrary angles (θ), we measured the resistance (R(H)) and critical current (Ic(H)) with AC and DC currents, respectively. At low fields below the PE, R(H) and Ic(H) showed a weak angular dependence, regardless of the type of excitation current, because of the stable vortex state. At intermediate fields near the PE, R(H) and Ic(H) at the onset of the PE varied with θ, depending on the type of external current, due to the metastability of the disordered vortex lattice near the PE. At high fields above the PE and near the upper critical field Hc2, the R(H) curves showed a simple scaling behavior with θ.

  8. Excessive magnetic field flux density distribution from overhead isolated powerline conductors due to neutral line current.

    PubMed

    Netzer, Moshe

    2013-06-01

    Overhead isolated powerline conductors (hereinafter: "OIPLC") are the most compact form for distributing low voltage currents. From the known physics of magnetic field emission from 3-phase power lines, it is expected that excellent symmetry of the 120° shifted phase currents and where compact configuration of the 3-phase+neutral line exist, the phase current vectorial summation of the magnetic field flux density (MFFD) is expected to be extremely low. However, despite this estimation, an unexpectedly very high MFFD was found in at least three towns in Israel. This paper explains the reasons leading to high MFFD emissions from compact OIPLC and the proper technique to fix it. Analysis and measurement results had led to the failure hypothsis of neutral line poor connection design and poor grounding design of the HV-LV utility transformers. The paper elaborates on the low MFFD exposure level setup by the Israeli Environmental Protection Office which adopted a rather conservative precaution principal exposure level (2 mG averaged over 24 h). PMID:23675630

  9. Generation mechanism of L-value dependence of oxygen flux enhancements during substorms

    NASA Astrophysics Data System (ADS)

    Nakayama, Y.; Ebihara, Y.; Tanaka, T.; Ohtani, S.; Gkioulidou, M.; Takahashi, K.; Kistler, L. M.; Kletzing, C.

    2015-12-01

    The Van Allen Probes Helium Oxygen Proton Electron (HOPE) instrument measures charged particles with an energy range from ~eV to ~ tens of keV. The observation shows that the energy flux of the particles increases inside the geosynchronous orbit during substorms. For some night-side events around the apogee, the energy flux of O+ ion enhances below ~10 keV at lower L shell, whereas the flux below ~8 keV sharply decreases at higher L shells. This structure of L-energy spectrogram of flux is observed only for the O+ ions. The purpose of this study is to investigate the generation mechanism of the structure by using numerical simulations. We utilized the global MHD simulation developed by Tanaka et al (2010, JGR) to simulate the electric and magnetic fields during substorms. We performed test particle simulation under the electric and magnetic fields by applying the same model introduced by Nakayama et al. (2015, JGR). In the test particle simulation each test particle carries the real number of particles in accordance with the Liouville theorem. Using the real number of particles, we reconstructed 6-dimensional phase space density and differential flux of O+ ions in the inner magnetosphere. We obtained the following results. (1) Just after the substorm onset, the dawn-to-dusk electric field is enhanced to ~ 20 mV/m in the night side tail region at L > 7. (2) The O+ ions are accelerated and transported to the inner region (L > ~5.5) by the large-amplitude electric field. (3) The reconstructed L-energy spectrogram shows a similar structure to the Van Allen Probes observation. (4) The difference in the flux enhancement between at lower L shell and higher L shells is due to two distinct acceleration processes: adiabatic and non-adiabatic. We will discuss the relationship between the particle acceleration and the structure of L-energy spectrogram of flux enhancement in detail.

  10. Higher order treatment on temporal derivative of angular flux for time-dependent MOC

    SciTech Connect

    Tsujita, K.; Endo, T.; Yamamoto, A.; Kamiyama, Y.; Kirimura, K.

    2013-07-01

    A new kinetic analysis method, whose angular dependence of temporal derivative for angular flux is accurately treated within practical memory requirement, is proposed. The method of characteristics (MOC) is being widely used for reactor analysis thanks to the advances of numerical algorithms and computer hardware. However, the computational resources, i.e., the memory capacity, can be still a crucial problem for rigorous kinetic calculations using MOC. In the straightforward approach for kinetic calculation using MOC, the segment-averaged angular fluxes should be stored on the memory in order to explicitly calculate the temporal derivative of the angular flux, which would require huge memory. Thus, in the conventional kinetic calculation code using MOC, the temporal derivative of the angular flux has been approximated as angularly isotropic in order to reduce the memory requirement (isotropic assumption). However, the approximation error caused by the conventional isotropic assumption has not been thoroughly and quantitatively investigated so far and an accurate kinetic calculation method, which can quantitatively estimate the above approximation error within practical memory storage, has not been developed. The present study tries to address this issue with a newly developed approach. Effect of the approximate treatment for the temporal derivative of angular flux is evaluated through benchmark calculations. (authors)

  11. The uncertainty of UTCI due to uncertainties in the determination of radiation fluxes derived from measured and observed meteorological data

    NASA Astrophysics Data System (ADS)

    Weihs, Philipp; Staiger, Henning; Tinz, Birger; Batchvarova, Ekaterina; Rieder, Harald; Vuilleumier, Laurent; Maturilli, Marion; Jendritzky, Gerd

    2012-05-01

    In the present study, we investigate the determination accuracy of the Universal Thermal Climate Index (UTCI). We study especially the UTCI uncertainties due to uncertainties in radiation fluxes, whose impacts on UTCI are evaluated via the mean radiant temperature ( Tmrt). We assume "normal conditions", which means that usual meteorological information and data are available but no special additional measurements. First, the uncertainty arising only from the measurement uncertainties of the meteorological data is determined. Here, simulations show that uncertainties between 0.4 and 2 K due to the uncertainty of just one of the meteorological input parameters may be expected. We then analyse the determination accuracy when not all radiation data are available and modelling of the missing data is required. Since radiative transfer models require a lot of information that is usually not available, we concentrate only on the determination accuracy achievable with empirical models. The simulations show that uncertainties in the calculation of the diffuse irradiance may lead to Tmrt uncertainties of up to ±2.9 K. If long-wave radiation is missing, we may expect an uncertainty of ±2 K. If modelling of diffuse radiation and of longwave radiation is used for the calculation of Tmrt, we may then expect a determination uncertainty of ±3 K. If all radiative fluxes are modelled based on synoptic observation, the uncertainty in Tmrt is ±5.9 K. Because Tmrt is only one of the four input data required in the calculation of UTCI, the uncertainty in UTCI due to the uncertainty in radiation fluxes is less than ±2 K. The UTCI uncertainties due to uncertainties of the four meteorological input values are not larger than the 6 K reference intervals of the UTCI scale, which means that UTCI may only be wrong by one UTCI scale. This uncertainty may, however, be critical at the two temperature extremes, i.e. under extreme hot or extreme cold conditions.

  12. Magnetic Flux Concentrations in Stratified Turbulent Plasma Due to Negative Effective Magnetic Pressure Instability

    NASA Astrophysics Data System (ADS)

    Jabbari, S.; Brandenburg, A.

    2014-12-01

    al. 2013). When the field is vertical, the resulting magnetic flux concentrations lead to the magnetic spots and can be of equipartition field strength. DNS, MFS, and implicit large eddy simulations (ILES) confirm that in a proper parameter regime, vertical imposed fields lead to the formation of circular magnetic spots (Brandenburg et al. 2014).

  13. INCLINATION-DEPENDENT ACTIVE GALACTIC NUCLEUS FLUX PROFILES FROM STRONG LENSING OF THE KERR SPACETIME

    SciTech Connect

    Chen, Bin; Dai, Xinyu; Baron, E.

    2013-01-10

    Recent quasar microlensing observations have constrained the X-ray emission sizes of quasars to be about 10 gravitational radii, one order of magnitude smaller than the optical emission sizes. Using a new ray-tracing code for the Kerr spacetime, we find that the observed X-ray flux is strongly influenced by the gravity field of the central black hole, even for observers at moderate inclination angles. We calculate inclination-dependent flux profiles of active galactic nuclei in the optical and X-ray bands by combining the Kerr lensing and projection effects for future reference. We further study the dependence of the X-ray-to-optical flux ratio on the inclination angle caused by differential lensing distortion of the X-ray and optical emission, assuming several corona geometries. The strong lensing X-ray-to-optical magnification ratio can change by a factor of {approx}10 for normal quasars in some cases, and a further factor of {approx}10 for broad absorption line (BAL) quasars and obscured quasars. Comparing our results with the observed distributions in normal and BAL quasars, we find that the inclination angle dependence of the magnification ratios can significantly change the X-ray-to-optical flux ratio distributions. In particular, the mean value of the spectrum slope parameter {alpha}{sub ox}, 0.3838log F {sub 2keV}/F {sub 2500A}, can differ by {approx}0.1-0.2 between normal and BAL quasars, depending on corona geometries, suggesting larger intrinsic absorptions in BAL quasars.

  14. Calculations of increased solar UV fluxes and DUV doses due to stratospheric-ozone depletions

    SciTech Connect

    Zardecki, A.; Gerstl, S.A.W.

    1982-02-01

    Accurate radiative transfer calculations are performed in the middle ultraviolet spectral region for aerosol-loaded atmospheres with the goal of determining the solar irradiance at the ground and quantifying the irradiance perturbations due to the presence of aerosols and various ozone depletions. The extent of the increase of UV-B radiation as a function of wave-length and solar zenith angle is calculated for five model atmospheres. In addition, the damaging ultraviolet dose rates and radiation amplification factors are evaluated at different latitudes and seasons for erythemal and DNA action spectra.

  15. Changes in Carbon Flux at the Duke Forest Hardwood Ameriflux Site Due to Land Cover/Land Use Changes

    NASA Astrophysics Data System (ADS)

    McCombs, A. G.

    2014-12-01

    The Raleigh/Durham, North Carolina metropolitan area has been ranked by Forbes as the fastest growing cities in the United States. As a result of the rapid growth, there has been a significant amount of urban sprawl. The objective of this study was to determine if the changes in land use and land cover have caused a change in the carbon flux near the Duke Forest AmeriFlux station that was active from 2001 to 2008. The land cover and land use were assessed every two years to determine how land cover has changed at the Duke Forest Hardwoods (US-Dk2) AmeriFlux site from 2001 to 2008 using Landsat scenes. The change in land cover and land use was then compared to changes in the carbon footprint that is computed annually from 2001 to 2008. The footprint model for each wind direction determined that there are changes annually and that the research will determine if these changes are due to annual weather patterns or land use and land cover changes.

  16. Time dependent theory of gapless d-wave superconductors: Application to the flux flow

    SciTech Connect

    Kopnin, N.B. |

    1998-02-01

    Time-dependent equations for a d-wave superconductor are derived for temperatures close to T{sub c} under the gapless condition {tau}{Delta}(T) {much_lt} 1. They differ from the usual time-dependent Ginzburg-Landau (TDGL) theory by an additional term which describes as diffusive relaxation of nonequilibrium excitations. These equations are applied to the problem of flux flow. The longitudinal conductivity is found to differ considerably from the Bardeen and Stephen model; the implication of this result for resistive measurements of the upper critical field is discussed. The Hall conductivity, however, coincides with the usual TDGL expression.

  17. Origin of dc voltage in type II superconducting flux pumps: field, field rate of change, and current density dependence of resistivity

    NASA Astrophysics Data System (ADS)

    Geng, J.; Matsuda, K.; Fu, L.; Fagnard, J.-F.; Zhang, H.; Zhang, X.; Shen, B.; Dong, Q.; Baghdadi, M.; Coombs, T. A.

    2016-03-01

    Superconducting flux pumps are the kind of devices which can generate direct current into superconducting circuit using external magnetic field. The key point is how to induce a dc voltage across the superconducting load by ac fields. Giaever (1966 IEEE Spectr. 3 117) pointed out flux motion in superconductors will induce a dc voltage, and demonstrated a rectifier model which depended on breaking superconductivity. van de Klundert et al (1981 Cryogenics 21 195, 267) in their review(s) described various configurations for flux pumps all of which relied on inducing the normal state in at least part of the superconductor. In this letter, following their work, we reveal that a variation in the resistivity of type II superconductors is sufficient to induce a dc voltage in flux pumps and it is not necessary to break superconductivity. This variation in resistivity is due to the fact that flux flow is influenced by current density, field intensity, and field rate of change. We propose a general circuit analogy for travelling wave flux pumps, and provide a mathematical analysis to explain the dc voltage. Several existing superconducting flux pumps which rely on the use of a travelling magnetic wave can be explained using the analysis enclosed. This work can also throw light on the design and optimization of flux pumps.

  18. Transient Convection Due to Imposed Heat Flux: Application to Liquid-Acquisition Devices

    NASA Technical Reports Server (NTRS)

    Duval, Walter M. B.; Chato, David J.; Doherty, Michael P.

    2014-01-01

    A model problem is considered that addresses the effect of heat load from an ambient laboratory environment on the temperature rise of liquid nitrogen inside an enclosure. This model has applications to liquid acquisition devices inside the cryogenic storage tanks used to transport vapor-free propellant to the main engine. We show that heat loads from Q = 0.001 to 10 W, with corresponding Rayleigh numbers from Ra = 109 to 1013, yield a range of unsteady convective states and temperature rise in the liquid. The results show that Q = 1 to 10 W (Ra = 1012 to 1013) yield temperature distributions along the enclosure height that are similar in trend to experimental measurements. Unsteady convection, which shows selfsimilarity in its planforms, is predicted for the range of heat-load conditions. The onset of convection occurs from a free-convection-dominated base flow that becomes unstable against convective instability generated at the bottom of the enclosure while the top of the enclosure is convectively stable. A number of modes are generated with small-scale thermals at the bottom of the enclosure in which the flow selforganizes into two symmetric modes prior to the onset of the propagation of the instability. These symmetric vertical modes transition to asymmetric modes that propagate as a traveling-wave-type motion of convective modes and are representative of the asymptotic convective state of the flow field. Intense vorticity production is created in the core of the flow field due to the fact that there is shear instability between the vertical and horizontal modes. For the higher Rayleigh numbers, 1012 to 1013, there is a transition from a stationary to a nonstationary response time signal of the flow and temperature fields with a mean value that increases with time over various time bands and regions of the enclosure.

  19. Magnetic Flux Concentrations in Stratified Turbulent Plasma Due to Negative Effective Magnetic Pressure Instability

    NASA Astrophysics Data System (ADS)

    Jabbari, Sarah

    2015-08-01

    We study a system of a highly stratified turbulent plasma. In such a system, when the magnetic Reynolds number is large enough and there is a background field of suitable strength, a new effect will play role in con- centrating magnetic fields such that it leads to the formation of magnetic spots and bipolar regions. This effect is due to the fact that the turbu- lent pressure is suppressed by the large-scale magnetic field, which adds a negative term to the total mean-field (effective) pressure. This leads to an instability, which is known as the negative effective magnetic pressure instability (NEMPI). Direct numerical simulations (DNS) of isothermally forced turbulence have shown that NEMPI leads to the formation of spots in the presence of an imposed field. Our main aim now is to use NEMPI to explain the formation of active regions and sunspots. To achieve this goal, we need to move progressively to more realistic models. Here we extend our model by allowing the magnetic field to be generated by a dy- namo. A dynamo plays an important role in solar activity. Therefore, it is of interest to investigate NEMPI in the presence of dynamo-generated magnetic fields. Mean-field simulations (MFS) of such systems in spheri- cal geometry have shown how these two instabilities work in concert. In fact NEMPI will be activated as long as the strength of the magnetic field generated by the dynamo is in a proper range (for more detail see Jab- bari et al. 2013). In our new study, we use DNS to investigate a similar system. The turbulence is forced in the entire spherical shell, but the forc- ing is made helical in the lower 30% of the shell, similar to the model of Mitra et al. (2014). We perform simulations using the Pencil Code for different density contrasts and other input parameters. We applied ver- tical field boundary conditions in the r direction. The results show that, when the stratification is high enough, intense bipolar regions form and as time passes, they expand

  20. The field-dependent shock profiles of a magnetorhelogical damper due to high impact: an experimental investigation

    NASA Astrophysics Data System (ADS)

    Kim, Hwan-Choong; Oh, Jong-Seok; Choi, Seung-Bok

    2015-02-01

    This work proposes a new damper featuring magnetorheological fluid (MR damper) and presents its field-dependent damping forces due to high impact. To achieve this goal, a large MR damper, which can produce a damping force of 100 kN at 6 A, is designed and manufactured based on the analysis of the magnetic flux intensity of the damper. After identifying the field-dependent damping force levels of the manufactured MR damper, a hydraulic horizontal shock tester is established. This shock testing system consists of a velocity generator, impact mass, shock programmer, and test mass. The MR damper is installed at the end of the wall in the shock tester and tested under four different experimental conditions. The shock profile characteristics of the MR damper due to different impact velocities are investigated at various input current levels. In addition, the inner pressure of the MR damper during impact, which depends on the input’s current level, is evaluated at two positions that can represent the pressure drop that generates the damping force of the MR damper. It is demonstrated from this impact testing that the shock profiles can be changed by the magnitude of the input current applied to the MR damper. It directly indicates that a desired shock profile can be achieved by installing the MR damper associated with appropriate control logics to adjust the magnitude of the input current.

  1. Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux

    PubMed Central

    Bai, Fan; Fink, Brian D.; Yu, Liping; Sivitz, William I.

    2016-01-01

    Oxygen consumption by isolated mitochondria is generally measured during state 4 respiration (no ATP production) or state 3 (maximal ATP production at high ADP availability). However, mitochondria in vivo do not function at either extreme. Here we used ADP recycling methodology to assess muscle mitochondrial function over intermediate clamped ADP concentrations. In so doing, we uncovered a previously unrecognized biphasic respiratory pattern wherein O2 flux on the complex II substrate, succinate, initially increased and peaked over low clamped ADP concentrations then decreased markedly at higher clamped concentrations. Mechanistic studies revealed no evidence that the observed changes in O2 flux were due to altered opening or function of the mitochondrial permeability transition pore or to changes in reactive oxygen. Based on metabolite and functional metabolic data, we propose a multifactorial mechanism that consists of coordinate changes that follow from reduced membrane potential (as the ADP concentration in increased). These changes include altered directional electron flow, altered NADH/NAD+ redox cycling, metabolite exit, and OAA inhibition of succinate dehydrogenase. In summary, we report a previously unrecognized pattern for complex II energized O2 flux. Moreover, our findings suggest that the ADP recycling approach might be more widely adapted for mitochondrial studies. PMID:27153112

  2. Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux.

    PubMed

    Bai, Fan; Fink, Brian D; Yu, Liping; Sivitz, William I

    2016-01-01

    Oxygen consumption by isolated mitochondria is generally measured during state 4 respiration (no ATP production) or state 3 (maximal ATP production at high ADP availability). However, mitochondria in vivo do not function at either extreme. Here we used ADP recycling methodology to assess muscle mitochondrial function over intermediate clamped ADP concentrations. In so doing, we uncovered a previously unrecognized biphasic respiratory pattern wherein O2 flux on the complex II substrate, succinate, initially increased and peaked over low clamped ADP concentrations then decreased markedly at higher clamped concentrations. Mechanistic studies revealed no evidence that the observed changes in O2 flux were due to altered opening or function of the mitochondrial permeability transition pore or to changes in reactive oxygen. Based on metabolite and functional metabolic data, we propose a multifactorial mechanism that consists of coordinate changes that follow from reduced membrane potential (as the ADP concentration in increased). These changes include altered directional electron flow, altered NADH/NAD+ redox cycling, metabolite exit, and OAA inhibition of succinate dehydrogenase. In summary, we report a previously unrecognized pattern for complex II energized O2 flux. Moreover, our findings suggest that the ADP recycling approach might be more widely adapted for mitochondrial studies. PMID:27153112

  3. On the existence of motion-induced heat flux due to thermoelastic waves in a one-dimensional solid rod

    NASA Astrophysics Data System (ADS)

    Semperlotti, Fabio; Sen, Mihir

    2014-03-01

    In this Letter, we show the existence of motion-induced heat transfer in homogeneous isotropic solids due to the propagation of thermoelastic waves. In particular, using the linearized governing equations for thermoelastic waves, we show that heat transfer in a one-dimensional rod is not only due to conduction but also to the local particle displacement a phenomenon which, in principle, is similar to advective heat transfer in fluids. It is found that the time-averaged heat transfer is dependent on both the material properties and the external excitation parameters. This mechanism can potentially be useful in ultrasonic welding and in the development of solid state refrigerators or heat pumps.

  4. The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression.

    PubMed

    Ewald, Jennifer C; Kuehne, Andreas; Zamboni, Nicola; Skotheim, Jan M

    2016-05-19

    Cell division entails a sequence of processes whose specific demands for biosynthetic precursors and energy place dynamic requirements on metabolism. However, little is known about how metabolic fluxes are coordinated with the cell division cycle. Here, we examine budding yeast to show that more than half of all measured metabolites change significantly through the cell division cycle. Cell cycle-dependent changes in central carbon metabolism are controlled by the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protein kinase A. At the G1/S transition, Cdk1 phosphorylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central carbon metabolism. Trehalose utilization fuels anabolic processes required to reliably complete cell division. Thus, the cell cycle entrains carbon metabolism to fuel biosynthesis. Because the oscillation of Cdk activity is a conserved feature of the eukaryotic cell cycle, we anticipate its frequent use in dynamically regulating metabolism for efficient proliferation. PMID:27203178

  5. Ion flux's pressure dependence in an asymmetric capacitively coupled rf discharge in NF3

    NASA Astrophysics Data System (ADS)

    Mateev, Emil; Zhelyazkov, Ivan

    2004-03-01

    Starting from an analytical macroscopic/phenomenological model yielding the self-bias voltage as a function of the absorbed radio-frequency (rf) power of an asymmetric capacitively coupled discharge in NF3 this paper studies the dependence of the ion flux onto the powered electrode on the gas pressure. An essential feature of the model is the assumption that the ions' drift velocity in the sheath near the powered electrode is proportional to E α, where E=-ΔU (U being the self-bias potential), and α is a coefficient depending on the gas pressure and cross section of elastic ion-neutral collisions. The model also considers the role of γ-electrons, stochastic heating as well as the contribution of the active electron current to the global discharge power balance. Numerically solving the model's basic equations one can extract the magnitude of the ion flux (at three different gas pressures) in a technological etching device (Alcatel GIR 220) by using easily measurable quantities, notably the self-bias voltage and absorbed rf power.

  6. Nonlinear thermoelectric response due to energy-dependent transport properties of a quantum dot

    NASA Astrophysics Data System (ADS)

    Svilans, Artis; Burke, Adam M.; Svensson, Sofia Fahlvik; Leijnse, Martin; Linke, Heiner

    2016-08-01

    Quantum dots are useful model systems for studying quantum thermoelectric behavior because of their highly energy-dependent electron transport properties, which are tunable by electrostatic gating. As a result of this strong energy dependence, the thermoelectric response of quantum dots is expected to be nonlinear with respect to an applied thermal bias. However, until now this effect has been challenging to observe because, first, it is experimentally difficult to apply a sufficiently large thermal bias at the nanoscale and, second, it is difficult to distinguish thermal bias effects from purely temperature-dependent effects due to overall heating of a device. Here we take advantage of a novel thermal biasing technique and demonstrate a nonlinear thermoelectric response in a quantum dot which is defined in a heterostructured semiconductor nanowire. We also show that a theoretical model based on the Master equations fully explains the observed nonlinear thermoelectric response given the energy-dependent transport properties of the quantum dot.

  7. Inter-element fractionation of highly siderophile elements in the Tonga Arc due to flux melting of a depleted source

    NASA Astrophysics Data System (ADS)

    Dale, Christopher W.; Macpherson, Colin G.; Pearson, D. Graham; Hammond, Samantha J.; Arculus, Richard J.

    2012-07-01

    Highly siderophile element concentrations (HSEs: Os, Ir, Ru, Pt, Pd, and Re) have been determined for a suite of fresh, submarine mafic lavas from the northern Tonga Arc front and the nascent backarc Fonualei Spreading Centre (FSC). Prior melt depletion of the Tongan mantle wedge combined with a high degree of fluid fluxed melting is thought to have produced boninitic magmas at several arc and FSC locations. As such, this arc system provides an opportunity to assess the fluid mobility of HSEs and to investigate the effects of fluid-induced melting and prior melt depletion on HSE behaviour during both mantle melting and magma evolution. Tongan lavas display extreme enrichment of Pt (2.5-32 ng/g) and Pd over Os (0.002-0.6 ng/g), Ir, and Ru, significantly greater than basalts from mid-ocean ridges. Magma evolution increases the degree of fractionation, resulting in the highest recorded Pt/Ru ratios (>300) in arc front samples with MgO <8 wt.%. This increasing fractionation is due to the mild incompatibility of Pt and Pd, and concurrent compatibility of Ru, during sulphide undersaturated magma evolution. However, the fractionation of Pt and Pd from Os, Ir, and Ru is observed in the highest MgO samples, indicating source inheritance. Prior melt depletion of the mantle and elevated oxygen fugacity both increase the likelihood of complete consumption of sulphide in the source during melting, which typically leads to melts with high concentrations of all the HSE. Indeed, modelling indicates that 25% aggregate partial melting of a depleted MORB-mantle source, proposed for the Tonga Arc, will lead to complete base-metal sulphide consumption unless there is considerable addition of S by the slab flux (at least 200 μg/g). Although source enrichment of Pt, Pd, and Re by slab fluids may take place, the fractionation of Pt and Pd from Os, Ir, and Ru can largely be explained by relatively low-temperature, yet high-degree, melting of fluid-fluxed melt-depleted mantle. The high Pt

  8. Seasonal to interannual depth-dependent changes in phosphorus flux in Cariaco Basin, Venezuela

    NASA Astrophysics Data System (ADS)

    Benitez-Nelson, C. R.; O'Neill, L.; Thunell, R.

    2004-12-01

    One of the major removal pathways of phosphorus (P) from the water column is through the formation, sinking, and burial of particles formed during marine biological production. Yet the flux of P containing particles to the seafloor remains one of the least studied components of the P cycle. In this study, particulate inorganic P (PIP) and particulate organic P (POP) fluxes were measured in a series of samples collected from sediment traps ranging in depth from 275 to 1255 m from November 1995 - November 2002 in Cariaco Basin, Venezuela. PIP concentrations averaged 40- 60 % (depending on depth) of the total particulate P (TPP) measured in the traps. PIP fluxes decreased by 75 % between the surface and deep waters, from a median of 28.6 to 6.3 \\mu mol m-2 d-1, whereas POP fluxes decreased by only 50 %, from 17.2 to 8.5 \\mu mol m-2 d-1. TPP, PIP and POP all vary seasonally and higher fluxes follow higher production during the upwelling season from late January to April. The relationship between particulate organic C (POC) and POP is relatively constant (POC:POP = 283) throughout the entire water column over the entire period (r2 = 0.58). However, there is a much tighter relationship between POP and POC in upwelling (January through April, r2 = 0.85) versus non upwelling (May through December, r2 = 0.40) seasons. Furthermore, upwelling, and hence higher production appears to be associated with higher POC:POP ratios (327 versus 258 in non upwelling periods). Higher than Redfield POC:POP ratios may indicate that preferential release of P containing organic matter is occurring, but if true, it is restricted to the upper 250 m of the water column above the shallowest sediment trap. An alternative explanation may be that the composition of plankton in the Cariaco Basin does not conform to the Redfield-ratio. Plankton tow samples collected over the upper 200 m with a > 200 um mesh had POC:POP ratios of 294 +/- 38. However, there is no other evidence that the euphotic zone

  9. An experimental measurement of metal multilayer x-ray reflectivity degradation due to intense x-ray flux

    SciTech Connect

    Hockaday, M.Y.P.

    1987-06-01

    The degradation of the x-ray reflection characteristics of metal multilayer Bragg diffractors due to intense x-ray flux was investigated. The Z-pinch plasma produced by PROTO II of Sandia National Laboratories, Albuquerque, New Mexico, was used as the source. The plasma generated total x-ray yields of as much as 40 kJ with up to 15 kJ in the neon hydrogen- and helium-like resonance lines in nominal 20-ns pulses. Molybdenum-carbon, palladium-carbon, and tungsten-carbon metal multilayers were placed at 15 and 150 cm from the plasma center. The multilayers were at nominal angles of 5/sup 0/ and 10/sup 0/ to diffract the neon resonance lines. The time-integrated x-ray reflection of the metal multilayers was monitored by x-ray film. A fluorescer-fiber optic-visible streak camera detector system was then used to monitor the time-resolved x-ray reflection characteristics of 135 A- 2d tungsten-carbon multilayers. A large specular component in the reflectivity prevented determination of the rocking curve of the multilayer. For a neon implosion onto a vanadium-doped polyacrylic acid foam target shot, detailed modeling was attempted. The spectral flux was determined with data from 5 XRD channels and deconvolved using the code SHAZAM. The observed decay in reflectivity was assumed to correspond to the melting of the first tungsten layer. A ''conduction factor'' of 82 was required to manipulate the heat loading of the first tungsten layer such that the time of melting corresponded to the observed decay. The power at destruction was 141 MW/cm/sup 2/ and the integrated energy at destruction was 2.0 J/cm/sup 2/. 82 refs., 66 figs., 10 tabs.

  10. Analytical Model for Estimating the Zenith Angle Dependence of Terrestrial Cosmic Ray Fluxes

    PubMed Central

    Sato, Tatsuhiko

    2016-01-01

    A new model called “PHITS-based Analytical Radiation Model in the Atmosphere (PARMA) version 4.0” was developed to facilitate instantaneous estimation of not only omnidirectional but also angular differential energy spectra of cosmic ray fluxes anywhere in Earth’s atmosphere at nearly any given time. It consists of its previous version, PARMA3.0, for calculating the omnidirectional fluxes and several mathematical functions proposed in this study for expressing their zenith-angle dependences. The numerical values of the parameters used in these functions were fitted to reproduce the results of the extensive air shower simulation performed by Particle and Heavy Ion Transport code System (PHITS). The angular distributions of ground-level muons at large zenith angles were specially determined by introducing an optional function developed on the basis of experimental data. The accuracy of PARMA4.0 was closely verified using multiple sets of experimental data obtained under various global conditions. This extension enlarges the model’s applicability to more areas of research, including design of cosmic-ray detectors, muon radiography, soil moisture monitoring, and cosmic-ray shielding calculation. PARMA4.0 is available freely and is easy to use, as implemented in the open-access EXcel-based Program for Calculating Atmospheric Cosmic-ray Spectrum (EXPACS). PMID:27490175

  11. Analytical Model for Estimating the Zenith Angle Dependence of Terrestrial Cosmic Ray Fluxes.

    PubMed

    Sato, Tatsuhiko

    2016-01-01

    A new model called "PHITS-based Analytical Radiation Model in the Atmosphere (PARMA) version 4.0" was developed to facilitate instantaneous estimation of not only omnidirectional but also angular differential energy spectra of cosmic ray fluxes anywhere in Earth's atmosphere at nearly any given time. It consists of its previous version, PARMA3.0, for calculating the omnidirectional fluxes and several mathematical functions proposed in this study for expressing their zenith-angle dependences. The numerical values of the parameters used in these functions were fitted to reproduce the results of the extensive air shower simulation performed by Particle and Heavy Ion Transport code System (PHITS). The angular distributions of ground-level muons at large zenith angles were specially determined by introducing an optional function developed on the basis of experimental data. The accuracy of PARMA4.0 was closely verified using multiple sets of experimental data obtained under various global conditions. This extension enlarges the model's applicability to more areas of research, including design of cosmic-ray detectors, muon radiography, soil moisture monitoring, and cosmic-ray shielding calculation. PARMA4.0 is available freely and is easy to use, as implemented in the open-access EXcel-based Program for Calculating Atmospheric Cosmic-ray Spectrum (EXPACS). PMID:27490175

  12. Scalings for unsteady natural convection boundary layers on an evenly heated plate with time-dependent heating flux

    NASA Astrophysics Data System (ADS)

    Lin, Wenxian; Armfield, S. W.

    2013-12-01

    It is of fundamental significance, especially with regard to application, to fully understand the flow behavior of unsteady natural convection boundary layers on a vertical plate heated by a time-dependent heat flux. Such an understanding is currently scarce. In this paper, the scaling analysis by Lin et al. [Phys. Rev. E 79, 066313 (2009), 10.1103/PhysRevE.79.066313] using a simple three-region structure for the unsteady natural convection boundary layer of a homogeneous Newtonian fluid with Pr >1 under isothermal heating was substantially extended for the case when the heating is due to a time-varying sinusoidal heat flux. A series of scalings was developed for the thermal boundary thickness, the plate temperature, the viscous boundary thicknesses, and the maximum vertical velocity within the boundary layer, which are the major parameters representing the flow behavior, in terms of the governing parameters of the flow, i.e., the Rayleigh number Ra, the Prandtl number Pr, and the dimensionless natural frequency fn of the time-varying sinusoidal heat flux, at the start-up stage, at the transition time scale which represents the ending of the start-up stage and the beginning of the transitional stage of the boundary-layer development, and at the quasi-steady stage. These scalings were validated by comparison to 10 full numerical solutions of the governing equations with Ra, Pr, and fn in the ranges 106≤Ra≤109, 3≤Pr≤100, and 0.01≤fn≤0.1 and were shown in general to provide an accurate description of the flow at different development stages, except for high-Pr runs in which a further, although weak, Pr dependence is present, which cannot be accurately predicted by the current scaling analysis using the simple three-region structure, attributed to the non-boundary-layer nature of the velocity field with high-Pr fluids. Some scalings at the transition time scale and at the quasi-steady stage also produce noticeable deviations from the numerical results when

  13. Latitudinal dependence of solar proton flux derived from interplanetary Lyman alpha emission

    NASA Astrophysics Data System (ADS)

    Nakagawa, H.; Fukunishi, H.; Watanabe, S.; Takahashi, Y.; Taguchi, M.; Bertaux, J.; Quemerais, E.; Lallement, R.

    2004-12-01

    There is a uniform flow of the interplanetary hydrogen in the solar system. The distribution of interplanetary neutral hydrogen is sensitive to solar wind proton flux, which has a latitudinal distribution, because interplanetary neutral hydrogen atoms are mainly ionized through a process of charge-exchange with solar wind protons (contributing to 80% of the total ionization rate). Rucinski et al. [1996] estimated the ionization rate of the interplanetary hydrogen in an average solar activity condition: 6.4±0.14 [10E-7/s] for charge exchange with protons. The most practical technique for determining the latitudinal dependence of the interplanetary hydrogen is observation of resonant backscatter of solar Lyman ƒ¿ emission at 121.6 nm. The interplanetary Lyman ƒ¿ emission has been measured by the ultraviolet imaging spectrometer (UVS) on board the Nozomi spacecraft crusing on its Mars transfer orbit with a periapsis of 1 AU and an apoapsis 1.5 AU from the Sun. The field-of-view of UVS is perpendicular to the spin axis of the spacecraft, which is controlled toward the Earth. The spatial resolution of UVS is 1.41 degrees in a plane perpendicular to the spin axis and 0.29 degrees in a plane including the spin axis. Spatial distributions are obtained from the full sky scanning of UVS with spin and orbital motions of the Nozomi spacecraft. One-year UVS data enable us to construct a full sky image of Lyman ƒ¿ emission. We present the results obtained from Nozomi/UVS data analysis for the period of 1999-2002. From a fitting of model calculations to the observed data, it is confirmed that a latitudinal anisotropy with the higher ionization region at the equator is reduced toward solar maximum. Finally, higher ionization region are found at the poles than at the equator near solar maximum. Basically, this change is produced by variations in the latitudinal dependence of persistent solar wind proton flux. However, proton flux from transient CMEs also affects the

  14. Characterization of time-dependent component reliability and availability effects due to aging

    NASA Astrophysics Data System (ADS)

    Hilsmeier, Todd Andrew

    The time-dependent effects of reliability and unavailability that occur due to the component first failure density and due to the maintenance policy are important since: (i) they may substantially deviate from static or average values, (ii) when these time-dependent effects are incorporated into a system, deviations can superimpose creating even greater deviations from static. Characterization of component reliability and unavailability effects due to aging is important for all engineering systems and has not been investigated. A general surveillance/repair policy including its constraints and limitations is defined. Potential dynamic variables under this surveillance/repair policy are identified, and a methodology for determining the most useful of these dynamic variables under this surveillance/repair policy are also developed. Under periodic surveillance and perfect detection/repair, expressions for time-dependent unavailability, failure frequency, and renewal frequency are developed from the general methodology. Under periodic surveillance, time-dependent failure frequency, w(t), unavailability, q(t), and probability of failure within test interval, Wsb{n}(T), are determined for Weibull and linear failure rates with aging threshold time, and normal failure density. These failure densities model component aging in nuclear power plants. The time-dependent variables are plotted and some important features that describe their time-dependent behavior (characteristics) are defined and determined directly from the plots. Using these characteristics, criteria are established to demonstrate the significance of dynamic modeling under periodic surveillance. It is observed that w(t) and q(t) may oscillate to values exceeding 5 times the static values during plant life. Also, dynamic periods may be on the order of years; therefore, dynamic modeling of q(t) and w(t) under periodic surveillance may be necessary. Under periodic surveillance, a simple non-recursive expression

  15. Uncertainties in wind speed dependent CO2 transfer velocities due to airflow distortion at anemometer sites on ships

    NASA Astrophysics Data System (ADS)

    Griessbaum, F.; Moat, B. I.; Narita, Y.; Yelland, M. J.; Klemm, O.; Uematsu, M.

    2009-09-01

    Data from research vessels and merchant ships are used to estimate ocean CO2 uptake via parameterizations of the gas transfer velocity (k) and measurements of the difference between the concentration of CO2 in the ocean (pCO2sw) and atmosphere (pCO2atm) and of wind speed. Gas transfer velocities estimated using wind speed dependent parameterisations may be in error due to air flow distortion by the ship's hull and superstructure introducing biases into the measured wind speed. The effect of airflow distortion on estimates of the transfer velocity was examined by modelling the airflow around the three-dimensional geometries of the research vessels Hakuho Maru and Mirai, using the Large Eddy Simulation code GERRIS. For airflows within ±45° of the bow the maximum bias was +16%. For wind speed of 10 m s-1 to 15 m s-1, a +16% bias in wind speed would cause an overestimate in the calculated value of k of 30% to 50%, depending on which k parameterisation is used. This is due to the propagation of errors when using quadratic or cubic parameterizations. Recommendations for suitable anemometer locations on research vessels are given. The errors in transfer velocity may be much larger for typical merchant ships, as the anemometers are generally not as well-exposed as those on research vessels. Flow distortion may also introduce biases in the wind speed dependent k parameterizations themselves, since these are obtained by relating measurements of the CO2 flux to measurements of the wind speed and the CO2 concentration difference. To investigate this, flow distortion effects were estimated for three different platforms from which wind speed dependent parameterizations are published. The estimates ranged from -4% to +14% and showed that flow distortion may have a significant impact on wind speed dependent parameterizations. However, the wind biases are not large enough to explain the differences at high wind speeds in parameterizations which are based on eddy covariance and

  16. Uncertainties in wind speed dependent CO2 transfer velocities due to airflow distortion at anemometer sites on ships

    NASA Astrophysics Data System (ADS)

    Griessbaum, F.; Moat, B. I.; Narita, Y.; Yelland, M. J.; Klemm, O.; Uematsu, M.

    2010-06-01

    Data from platforms, research vessels and merchant ships are used to estimate ocean CO2 uptake via parameterisations of the gas transfer velocity (k) and measurements of the difference between the partial pressures of CO2 in the ocean (pCO2 sw) and atmosphere (pCO2 atm) and of wind speed. Gas transfer velocities estimated using wind speed dependent parameterisations may be in error due to air flow distortion by the ship's hull and superstructure introducing biases into the measured wind speed. The effect of airflow distortion on estimates of the transfer velocity was examined by modelling the airflow around the three-dimensional geometries of the research vessels Hakuho Maru and Mirai, using the Large Eddy Simulation code GERRIS. For airflows within ±45° of the bow the maximum bias was +16%. For wind speed of 10 m s-1 to 15 m s-1, a +16% bias in wind speed would cause an overestimate in the calculated value of k of 30% to 50%, depending on which k parameterisation is used. This is due to the propagation of errors when using quadratic or cubic parameterisations. Recommendations for suitable anemometer locations on research vessels are given. The errors in transfer velocity may be much larger for typical merchant ships, as the anemometers are generally not as well-exposed as those on research vessels. Flow distortion may also introduce biases in the wind speed dependent k parameterisations themselves, since these are obtained by relating measurements of the CO2 flux to measurements of the wind speed and the CO2 concentration difference. To investigate this, flow distortion effects were estimated for three different platforms from which wind speed dependent parameterisations are published. The estimates ranged from -4% to +14% and showed that flow distortion may have a significant impact on wind speed dependent parameterisations. However, the wind biases are not large enough to explain the differences at high wind speeds in parameterisations which are based on eddy

  17. LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

    PubMed

    Doonan, Patrick J; Chandramoorthy, Harish C; Hoffman, Nicholas E; Zhang, Xueqian; Cárdenas, César; Shanmughapriya, Santhanam; Rajan, Sudarsan; Vallem, Sandhya; Chen, Xiongwen; Foskett, J Kevin; Cheung, Joseph Y; Houser, Steven R; Madesh, Muniswamy

    2014-11-01

    Dysregulation of mitochondrial Ca(2+)-dependent bioenergetics has been implicated in various pathophysiological settings, including neurodegeneration and myocardial infarction. Although mitochondrial Ca(2+) transport has been characterized, and several molecules, including LETM1, have been identified, the functional role of LETM1-mediated Ca(2+) transport remains unresolved. This study examines LETM1-mediated mitochondrial Ca(2+) transport and bioenergetics in multiple cell types, including fibroblasts derived from patients with Wolf-Hirschhorn syndrome (WHS). The results show that both mitochondrial Ca(2+) influx and efflux rates are impaired in LETM1 knockdown, and similar phenotypes were observed in ΔEF hand, (D676A D688K)LETM1 mutant-overexpressed cells, and in cells derived from patients with WHS. Although LETM1 levels were lower in WHS-derived fibroblasts, the mitochondrial Ca(2+) uniporter components MCU, MCUR1, and MICU1 remain unaltered. In addition, the MCU mitoplast patch-clamp current (IMCU) was largely unaffected in LETM1-knockdown cells. Silencing of LETM1 also impaired basal mitochondrial oxygen consumption, possibly via complex IV inactivation and ATP production. Remarkably, LETM1 knockdown also resulted in increased reactive oxygen species production. Further, LETM1 silencing promoted AMPK activation, autophagy, and cell cycle arrest. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics. These findings reveal the role of LETM1-dependent mitochondrial Ca(2+) flux in shaping cellular bioenergetics. PMID:25077561

  18. Beam test results of the dependence of signal size on incident particle flux in diamond pixel and pad detectors

    NASA Astrophysics Data System (ADS)

    Wallny, R.

    2015-07-01

    We present results of beam tests of charged particle detectors based on single-crystal and poly-crystalline Chemical Vapor Deposition (CVD) diamond. We measured the signal pulse height dependence on the particle flux. The detectors were tested over a range of particle fluxes from 2 kHz/cm2 to 20 MHz/cm2. The pulse height of the sensors was measured with pad and pixel readout electronics. The pulse height of the non-irradiated single-crystal CVD diamond pad sensors was stable with respect to flux, while the pulse height of irradiated single-crystal CVD diamond pad sensors decreased with increasing particle flux. The pulse height of the non-irradiated single-crystal CVD diamond pixel detectors decreased slightly with increasing particle flux while the pulse height of the irradiated single-crystal CVD diamond pixel detectors decreased significantly with increasing particle flux. The observed sensitivity to flux is similar in both the diamond pad sensors constructed using diamonds from the Pixel Luminosity Telescope (PLT) irradiated during its pilot run in the Compact Muon Solenoid (CMS) detector and in neutron irradiated diamond pad sensors from the same manufacturer irradiated to the same fluence of neutrons. The pulse height for irradiated poly-crystalline CVD diamond pad sensors proved to be stable with respect to particle flux.

  19. Isotopically nonstationary 13C flux analysis of changes in Arabidopsis thaliana leaf metabolism due to high light acclimation.

    PubMed

    Ma, Fangfang; Jazmin, Lara J; Young, Jamey D; Allen, Doug K

    2014-11-25

    Improving plant productivity is an important aim for metabolic engineering. There are few comprehensive methods that quantitatively describe leaf metabolism, although such information would be valuable for increasing photosynthetic capacity, enhancing biomass production, and rerouting carbon flux toward desirable end products. Isotopically nonstationary metabolic flux analysis (INST-MFA) has been previously applied to map carbon fluxes in photoautotrophic bacteria, which involves model-based regression of transient (13)C-labeling patterns of intracellular metabolites. However, experimental and computational difficulties have hindered its application to terrestrial plant systems. We performed in vivo isotopic labeling of Arabidopsis thaliana rosettes with (13)CO2 and estimated fluxes throughout leaf photosynthetic metabolism by INST-MFA. Plants grown at 200 µmol m(-2)s(-1) light were compared with plants acclimated for 9 d at an irradiance of 500 µmol⋅m(-2)⋅s(-1). Approximately 1,400 independent mass isotopomer measurements obtained from analysis of 37 metabolite fragment ions were regressed to estimate 136 total fluxes (54 free fluxes) under each condition. The results provide a comprehensive description of changes in carbon partitioning and overall photosynthetic flux after long-term developmental acclimation of leaves to high light. Despite a doubling in the carboxylation rate, the photorespiratory flux increased from 17 to 28% of net CO2 assimilation with high-light acclimation (Vc/Vo: 3.5:1 vs. 2.3:1, respectively). This study highlights the potential of (13)C INST-MFA to describe emergent flux phenotypes that respond to environmental conditions or plant physiology and cannot be obtained by other complementary approaches. PMID:25368168

  20. Methane fluxes show consistent temperature dependence across microbial to ecosystem scales.

    PubMed

    Yvon-Durocher, Gabriel; Allen, Andrew P; Bastviken, David; Conrad, Ralf; Gudasz, Cristian; St-Pierre, Annick; Thanh-Duc, Nguyen; del Giorgio, Paul A

    2014-03-27

    Methane (CH4) is an important greenhouse gas because it has 25 times the global warming potential of carbon dioxide (CO2) by mass over a century. Recent calculations suggest that atmospheric CH4 emissions have been responsible for approximately 20% of Earth's warming since pre-industrial times. Understanding how CH4 emissions from ecosystems will respond to expected increases in global temperature is therefore fundamental to predicting whether the carbon cycle will mitigate or accelerate climate change. Methanogenesis is the terminal step in the remineralization of organic matter and is carried out by strictly anaerobic Archaea. Like most other forms of metabolism, methanogenesis is temperature-dependent. However, it is not yet known how this physiological response combines with other biotic processes (for example, methanotrophy, substrate supply, microbial community composition) and abiotic processes (for example, water-table depth) to determine the temperature dependence of ecosystem-level CH4 emissions. It is also not known whether CH4 emissions at the ecosystem level have a fundamentally different temperature dependence than other key fluxes in the carbon cycle, such as photosynthesis and respiration. Here we use meta-analyses to show that seasonal variations in CH4 emissions from a wide range of ecosystems exhibit an average temperature dependence similar to that of CH4 production derived from pure cultures of methanogens and anaerobic microbial communities. This average temperature dependence (0.96 electron volts (eV)), which corresponds to a 57-fold increase between 0 and 30°C, is considerably higher than previously observed for respiration (approximately 0.65 eV) and photosynthesis (approximately 0.3 eV). As a result, we show that both the emission of CH4 and the ratio of CH4 to CO2 emissions increase markedly with seasonal increases in temperature. Our findings suggest that global warming may have a large impact on the relative contributions of CO2 and CH

  1. Energy dependent time delays of kHz oscillations due to thermal Comptonization

    NASA Astrophysics Data System (ADS)

    Kumar, Nagendra; Misra, Ranjeev

    2014-12-01

    We study the energy dependent photon variability from a thermal Comptonizing plasma that is oscillating at kHz frequencies. In particular, we solve the linearized time-dependent Kompaneets equation and consider the oscillatory perturbation to be either in the soft photon source or in the heating rate of the plasma. For each case, we self consistently consider the energy balance of the plasma and the soft photon source. The model incorporates the possibility of a fraction of the Comptonized photons impinging back into the soft photon source. We find that when the oscillation is due to the soft photon source, the variation of the fractional root mean sqaure (rms) is nearly constant with energy and the time-lags are hard. However, for the case when the oscillation is due to variation in the heating rate of the corona, and when a significant fraction of the photons impinge back into the soft photon source, the rms increases with energy and the time-lags are soft. As an example, we compare the results with the ˜850 Hz oscillation observed on 1996 March 3 for 4U 1608-52 and show that both the observed soft time-lags as well as the rms versus energy can be well described by such a model where the size of the Comptonizing plasma is ˜1 km. Thus, modelling of the time-lags as due to Comptonization delays, can provide tight constraints on the size and geometry of the system. Detailed analysis would require well-constrained spectral parameters.

  2. Food-dependent exercise-induced anaphylaxis due to wheat in a young woman.

    PubMed

    Ahanchian, Hamid; Farid, Reza; Ansari, Elham; Kianifar, Hamid Reza; Jabbari Azad, Farahzad; Jafari, Seyed Ali; Purreza, Reza; Noorizadeh, Shadi

    2013-03-01

    Food Dependent Exercise-Induced Allergy is a rare condition. However, the occurrence of anaphylaxis is increasing especially in young people. The diagnosis of anaphylaxis is based on clinical criteria and can be supported by laboratory tests such as serum tryptase and positive skin test results for specific IgE to potential triggering allergens. Anaphylaxis prevention needs strict avoidance of confirmed relevant allergen. Food-exercise challenge test may be an acceptable method for diagnosis of Food Dependent Exercise-Induced Allergy and dietary elimination of food is recommended to manage it. In this study, a 32 year-old woman visited the allergy clinic with a history of several episodes of hives since 11 years ago and 3 life-threatening attacks of anaphylaxis during the previous 6 months. The onsets of majority of these attacks were due to physical activity after breakfast. On Blood RAST test, the panel of common food Allergens was used and she had positive test only to wheat flour. On skin prick tests for common food allergens she showed a 6 millimeter wheal with 14 mm flare to Wheat Extract. The rest of allergens were negative.The patient was diagnosed as wheat-dependent exercise-induced, and all foods containing wheat were omitted from her diet. In this report we emphasized on the importance of careful history taking in anaphylaxis diagnosis. PMID:23454785

  3. Breaks of dose dependence of transient creep as result of competing influence of defects’ fluxes on climb of dislocations

    NASA Astrophysics Data System (ADS)

    Selyshchev, P.

    2015-04-01

    In the framework of climb-glide model a theoretical approach is developed to describe transient creep under irradiation. It is obtained the explicit expression for creep rate which describes experimentally observed breaks of dose dependence of creep. It is shown that the breaks arise as result of competition of radiation and thermal fluxes of defects to dislocation. When interstitial and vacancy fluxes become equal, the dislocation cannot overcome the obstacle via climbing and cannot continue glide. Climb-glide mechanism does not contribute to the creep. The creep rate drops. Numbers of breaks depend on initial state of material and conditions of irradiation. Dose (time) of break appearance are obtained.

  4. Multispecies Density and Temperature Gradient Dependence of Quasilinear Particle and Energy Fluxes

    SciTech Connect

    G. Rewoldt; R.V. Budny; W.M. Tang

    2004-08-09

    The variations of the normalized quasilinear particle and energy fluxes with artificial changes in the density and temperature gradients, as well as the variations of the linear growth rates and real frequencies, for ion temperature gradient and trapped-electron modes, are calculated. The quasilinear fluxes are normalized to the total energy flux, summed over all species. Here, realistic cases for tokamaks and spherical torii are considered which have two impurity species. For situations where there are substantial changes in the normalized fluxes, the ''diffusive approximation,'' in which the normalized fluxes are taken to be linear in the gradients, is seen to be inaccurate. Even in the case of small artificial changes in density or temperature gradients, changes in the fluxes of different species (''off-diagonal'') generally are significant, or even dominant, compared to those for the same species (''diagonal'').

  5. PLANETESIMAL FORMATION IN MAGNETOROTATIONALLY DEAD ZONES: CRITICAL DEPENDENCE ON THE NET VERTICAL MAGNETIC FLUX

    SciTech Connect

    Okuzumi, Satoshi; Hirose, Shigenobu

    2012-07-01

    Turbulence driven by magnetorotational instability (MRI) affects planetesimal formation by inducing diffusion and collisional fragmentation of dust particles. We examine conditions preferred for planetesimal formation in MRI-inactive 'dead zones' using an analytic dead-zone model based on our recent resistive MHD simulations. We argue that successful planetesimal formation requires not only a sufficiently large dead zone (which can be produced by tiny dust grains) but also a sufficiently small net vertical magnetic flux (NVF). Although often ignored, the latter condition is indeed important since the NVF strength determines the saturation level of turbulence in MRI-active layers. We show that direct collisional formation of icy planetesimal across the fragmentation barrier is possible when the NVF strength is lower than 10 mG (for the minimum-mass solar nebula model). Formation of rocky planetesimals via the secular gravitational instability is also possible within a similar range of the NVF strength. Our results indicate that the fate of planet formation largely depends on how the NVF is radially transported in the initial disk formation and subsequent disk accretion processes.

  6. Water and Carbon Fluxes in a Semi-Arid Region Floodplain: Multiple Approaches to Constrain Estimates of Seasonal- and Depth Dependent Fluxes at Rifle, Colorado

    NASA Astrophysics Data System (ADS)

    Tokunaga, T. K.; Wan, J.; Dong, W.; Kim, Y.; Williams, K. H.; Conrad, M. E.; Christensen, J. N.; Bill, M.; Faybishenko, B.; Hobson, C.; Dayvault, R.; Long, P. E.; Hubbard, S. S.

    2014-12-01

    at the soil surface are consistent with estimates based on season- and temperature-dependent diffusion and respiration within the vadose zone. Thus, fairly predictable seasonal variations in water table elevation, evapotranspiration, and temperature can help constrain estimates of water and carbon fluxes.

  7. Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: dependence upon both fluxes and forces.

    PubMed

    Rigoulet, M; Leverve, X; Fontaine, E; Ouhabi, R; Guérin, B

    1998-07-01

    The purpose of this work was to show how the quantitative definition of the different parameters involved in mitochondrial oxidative phosphorylation makes it possible to characterize the mechanisms by which the yield of ATP synthesis is affected. Three different factors have to be considered: (i) the size of the different forces involved (free energy of redox reactions and ATP synthesis, proton electrochemical difference); (ii) the physical properties of the inner mitochondrial membrane in terms of leaks (H+ and cations); and finally (iii) the properties of the different proton pumps involved in this system (kinetic properties, regulation, modification of intrinsic stoichiometry). The data presented different situations where one or more of these parameters are affected, leading to a different yield of oxidative phosphorylation. (1) By manipulating the actual flux through each of the respiratory chain units at constant protonmotive force in yeast mitochondria, we show that the ATP/O ratio decreases when the flux increases. Moreover, the highest efficiency was obtained when the respiratory rate was low and almost entirely controlled by the electron supply. (2) By using almitrine in different kinds of mitochondria, we show that this drug leads to a decrease in ATP synthesis efficiency by increasing the H+/ATP stoichiometry ofATP synthase (Rigoulet M et al. Biochim Biophys Acta 1018: 91-97, 1990). Since this enzyme is reversible, it was possible to test the effect of this drug on the reverse reaction of the enzyme i.e. extrusion of protons catalyzed by ATP hydrolysis. Hence, we are able to prove that, in this case, the decrease in efficiency of oxidative phosphorylation is due to a change in the mechanistic stoichiometry of this proton pump. To our knowledge, this is the first example of a modification in oxidative phosphorylation yield by a change in mechanistic stoichiometry of one of the proton pumps involved. (3) In a model of polyunsaturated fatty acid deficiency

  8. Pharmacological and genetic reversal of age dependent cognitive deficits due to decreased presenilin function

    PubMed Central

    McBride, Sean M. J.; Choi, Catherine H.; Schoenfeld, Brian P.; Bell, Aaron J.; Liebelt, David A.; Ferreiro, David; Choi, Richard J.; Hinchey, Paul; Kollaros, Maria; Terlizzi, Allison M.; Ferrick, Neal J.; Koenigsberg, Eric; Rudominer, Rebecca L.; Sumida, Ai; Chiorean, Stephanie; Siwicki, Kathleen K.; Nguyen, Hanh T.; Fortini, Mark E.; McDonald, Thomas V.; Jongens, Thomas A.

    2010-01-01

    Alzheimer's disease is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are due to mutations in a single copy of the Presenilin (PS) and Amyloid Precursor Protein (APP) genes. The dominant inheritance pattern of FAD indicates that it may be due to gain or change of function mutations. Studies of FAD-linked forms of presenilin in model organisms, however, indicate that they are loss of function, leading to the possibility that a reduction in PS activity might contribute to FAD and that proper psn levels are important for maintaining normal cognition throughout life. To explore this issue further, we have tested the effect of reducing psn activity during aging in Drosophila melanogaster males. We have found that flies in which the dosage of psn function is reduced by 50% display age-onset impairments in learning and memory. Treatment with metabotropic glutamate receptor (mGluR) antagonists or lithium during the aging process prevented the onset of these deficits, and treatment of aged flies reversed the age-dependent deficits. Genetic reduction of DmGluRA, the inositol trisphosphate receptor (InsP3R) or IPPase also prevented these age-onset cognitive deficits. These findings suggest that reduced psn activity may contribute to the age onset cognitive loss observed with FAD. They also indicate that enhanced mGluR signaling and calcium release regulated by InsP3R as underlying causes of the age-dependent cognitive phenotypes observed when psn activity is reduced. PMID:20631179

  9. Convective radial energy flux due to resonant magnetic perturbations and magnetic curvature at the tokamak plasma edge

    SciTech Connect

    Marcus, F. A.; Beyer, P.; Fuhr, G.; Monnier, A.; Benkadda, S.

    2014-08-15

    With the resonant magnetic perturbations (RMPs) consolidating as an important tool to control the transport barrier relaxation, the mechanism on how they work is still a subject to be clearly understood. In this work, we investigate the equilibrium states in the presence of RMPs for a reduced MHD model using 3D electromagnetic fluid numerical code with a single harmonic RMP (single magnetic island chain) and multiple harmonics RMPs in cylindrical and toroidal geometry. Two different equilibrium states were found in the presence of the RMPs with different characteristics for each of the geometries used. For the cylindrical geometry in the presence of a single RMP, the equilibrium state is characterized by a strong convective radial thermal flux and the generation of a mean poloidal velocity shear. In contrast, for toroidal geometry, the thermal flux is dominated by the magnetic flutter. For multiple RMPs, the high amplitude of the convective flux and poloidal rotation are basically the same in cylindrical geometry, but in toroidal geometry the convective thermal flux and the poloidal rotation appear only with the islands overlapping of the linear coupling between neighbouring poloidal wavenumbers m, m – 1, and m + 1.

  10. The evolution of biomass-burning aerosol size distributions due to coagulation: dependence on fire and meteorological details and parameterization

    NASA Astrophysics Data System (ADS)

    Sakamoto, Kimiko M.; Laing, James R.; Stevens, Robin G.; Jaffe, Daniel A.; Pierce, Jeffrey R.

    2016-06-01

    Biomass-burning aerosols have a significant effect on global and regional aerosol climate forcings. To model the magnitude of these effects accurately requires knowledge of the size distribution of the emitted and evolving aerosol particles. Current biomass-burning inventories do not include size distributions, and global and regional models generally assume a fixed size distribution from all biomass-burning emissions. However, biomass-burning size distributions evolve in the plume due to coagulation and net organic aerosol (OA) evaporation or formation, and the plume processes occur on spacial scales smaller than global/regional-model grid boxes. The extent of this size-distribution evolution is dependent on a variety of factors relating to the emission source and atmospheric conditions. Therefore, accurately accounting for biomass-burning aerosol size in global models requires an effective aerosol size distribution that accounts for this sub-grid evolution and can be derived from available emission-inventory and meteorological parameters. In this paper, we perform a detailed investigation of the effects of coagulation on the aerosol size distribution in biomass-burning plumes. We compare the effect of coagulation to that of OA evaporation and formation. We develop coagulation-only parameterizations for effective biomass-burning size distributions using the SAM-TOMAS large-eddy simulation plume model. For the most-sophisticated parameterization, we use the Gaussian Emulation Machine for Sensitivity Analysis (GEM-SA) to build a parameterization of the aged size distribution based on the SAM-TOMAS output and seven inputs: emission median dry diameter, emission distribution modal width, mass emissions flux, fire area, mean boundary-layer wind speed, plume mixing depth, and time/distance since emission. This parameterization was tested against an independent set of SAM-TOMAS simulations and yields R2 values of 0.83 and 0.89 for Dpm and modal width, respectively. The

  11. Geoid Height Time Dependence Due to Global Glacial Isostatic Adjustment: The Critical Influence of Rotational Feedback

    NASA Astrophysics Data System (ADS)

    Peltier, W.

    2006-05-01

    It has recently been suggested in Mitrovica, Wahr et al.(2005. Geophys. J. Int. 161, 491-506) that the theory previously developed to predict the Earth's rotational response to the Late Quaternary glaciation-deglaciation cycle may require modification. This theory was initially described in Peltier (1982, Advances in Geophysics 24, 1-146) and in Wu and Peltier (1984, Geophys. J. R. astr. Soc. 76, 202-242). Its importance for understanding the GIA contribution to the modern rate of geoid height time dependence that is currently being measured by the GRACE satellite system lies in the fact that the polar wander induced by the ice-age cycle contributes to this field in an important way. It has proven possible to test the quality of the original form of the theory in a definitive way by employing Holocene inferences of relative sea level history based upon radio- carbon dated sea level index points. This test relies upon data from a wide range of sites on the Earth's surface, sites located in regions that are expcted to be most strongly influenced by the feedback of the polar wander component of the Earth's rotatonal response to the glaciation cycle onto sea level history itself. Application of the test demonstrates that the claims made in the Mitrovica, Wahr et al. paper concerning the existence of a flaw in the theory are incorrect. The previously published ICE-5G(VM2)prediction of the expected geoid height time dependence due to the GIA process is therefor secure (see Peltier, 2005. QSR 24, 1655- 1671).

  12. ENERGY INJECTION VIA FLUX EMERGENCE ON THE SUN DEPENDING ON THE GEOMETRIC SHAPE OF MAGNETIC FIELD

    SciTech Connect

    Magara, T.

    2011-04-20

    Flux emergence is a complicated process involving flow and magnetic field, which provides a way of injecting magnetic energy into the solar atmosphere. We show that energy injection via this complicated process is characterized by a physical quantity called the emergence velocity, which is determined by the spatial relationship between the flow velocity and magnetic field vectors. By using this quantity, we demonstrate that the geometric shape of magnetic field might play an important role in the energy injection via flux emergence.

  13. Solar flux-density distribution due to partially shaded/blocked mirrors using the separation of variables/superposition technique with polynomial and Gaussian sunshapes

    SciTech Connect

    Elsayed, M.; Fathalah, K.A.

    1996-05-01

    In a previous work, the separation of a variable/superposition technique was used to predict the flux density distribution on the receiver surfaces of solar central receiver plants. In this paper further developments of the technique are given. A numerical technique is derived to carry out the convolution of the sunshape and error density functions. Also, a simplified numerical procedure is presented to determine the basic flux density function on which the technique depends. The technique is used to predict the receiver solar flux distribution using two sunshapes, polynomial and Gaussian distributions. The results predicted with the technique are validated by comparison with experimental results from mirrors both with and without partial shading/blocking of their surfaces.

  14. Dynamic superconcentration at critical-point double-layer gates of conducting nanoporous granules due to asymmetric tangential fluxes

    PubMed Central

    Wang, Shau-Chun; Wei, Hsien-Hung; Chen, Hsiao-Ping; Tsai, Min-Hsuan; Yu, Chun-Ching; Chang, Hsueh-Chia

    2008-01-01

    A transient 106-fold concentration of double-layer counterions by a high-intensity electric field is demonstrated at the exit pole of a millimeter-sized conducting nanoporous granule that permits ion permeation. The phenomenon is attributed to a unique counterion screening dynamics that transforms half of the surface field into a converging one toward the ejecting pole. The resulting surface conduction flux then funnels a large upstream electro-osmotic convective counterion flux into the injecting hemisphere toward the zero-dimensional gate of the ejecting hemisphere to produce the superconcentration. As the concentrated counterion is ejected into the electroneutral bulk electrolyte, it attracts co-ions and produce a corresponding concentration of the co-ions. This mechanism is also shown to trap and concentrate co-ion microcolloids of micron sizes too (macroions) and hence has potential application in bead-based molecular assays. PMID:19693364

  15. Temperature dependence of bromine activation due to reaction with ozone in a proxy for organic aerosols

    NASA Astrophysics Data System (ADS)

    Edebeli, Jacinta; Ammann, Markus; Gilgen, Anina; Eichler, Anja; Schneebeli, Martin; Bartels-Rausch, Thorsten

    2016-04-01

    The discovery of boundary layer ozone depletion events in the Polar Regions [1] and in the mid-latitudes [2], two areas of very different temperature regimes, begs the question of temperature dependence of reactions responsible for these observations [3]. These ODEs have been attributed to ozone reacting with halides leading to reactive halogens (halogen activation) of which bromide is extensively studied, R1 - R3 [4, 5] (R1 is a multiphase reaction). O3 + Br‑→ O2 + OBr‑ (R1) OBr‑ + H+ ↔ HOBr (R2) HOBr + H+ + Br‑→ Br2 + H2O (R3) Despite extensive studies of ozone-bromide interactions, the temperature dependence of bromine activation is not clear [3]. This limits parameterization of the involved reactions and factors in atmospheric models [3, 6]. Viscosity changes in the matrix (such as organic aerosols) due to temperature have been shown to influence heterogeneous reaction rates and products beyond pure temperature effect [7]. With the application of coated wall flow-tubes, the aim of this study is therefore to investigate the temperature dependence of bromine activation by ozone interaction while attempting to characterize the contributions of the bulk and surface reactions to observed ozone uptake. Citric acid is used in this study as a hygroscopically characterized matrix whose viscosity changes with temperature and humidity. Here, we present reactive ozone uptake measured between 258 and 289 K. The data show high reproducibility. Comparison of measured uptake with modelled bulk uptake at different matrix compositions (and viscosities) indicate that bulk reactive uptake dominates, but there are other factors which still need further consideration in the model. References 1. Barrie, L.A., et al., Nature, 1988. 334: p. 138 - 141. 2. Hebestreit, K., et al., Science, 1999. 283: p. 55-57. 3. Simpson, W.R., et al., Atmospheric Chemistry and Physics, 2007. 7: p. 4375 - 4418. 4. Haag, R.W. and J. Hoigné, Environ Sci Technol, 1983. 17: p. 261-267. 5. Oum

  16. Verification and validation of the maximum entropy method of moment reconstruction of energy dependent neutron flux

    NASA Astrophysics Data System (ADS)

    Crawford, Douglas Spencer

    Verification and Validation of reconstructed neutron flux based on the maximum entropy method, is presented in this paper. The verification is carried out by comparing the neutron flux spectrum from the maximum entropy method with Monte Carlo N Particle 5 version 1.40 (MCNP5) and Attila-7.1.0-beta (Attila). A spherical 100% 235U critical assembly is modeled as the test case to compare the three methods. The verification error range for the maximum entropy method is 15% to 23% where MCNP5 is taken to be the comparison standard. Attila relative error for the critical assembly is 20% to 35%. Validation is accomplished by comparing a neutron flux spectrum that is back calculated from foil activation measurements performed in the GODIVA experiment (GODIVA). The error range of the reconstructed flux compared to GODIVA is 0%-10%. The error range of the neutron flux spectrum from MCNP5 compared to GODIVA is 0%-20% and the Attila error range compared to the GODIVA is 0%-35%. The maximum entropy method for reconstructing flux is shown to be a fast reliable method, compared to either Monte Carlo methods (MCNP5) or 30 multienergy group methods (Attila) and with respect to the GODIVA experiment.

  17. Measurement of Heat Flux and Heat Transfer Coefficient Due to Spray Application for the Die Casting Process

    SciTech Connect

    Sabau, Adrian S

    2007-01-01

    Lubricant spray application experiments were conducted for the die casting process. The heat flux was measured in situ using a differential thermopile sensor for three application techniques. First, the lubricant was applied under a constant flowrate while the nozzle was held in the same position. Second, the lubricant was applied in a pulsed, static manner, in which the nozzle was held over the same surface while it was turned on and off several times. Third, the lubricant was applied in a sweeping manner, in which the nozzle was moved along the die surface while it was held open. The experiments were conducted at several die temperatures and at sweep speeds of 20, 23, and 68 cm/s. The heat flux data, which were obtained with a sensor that was located in the centre of the test plate, were presented and discussed. The sensor can be used to evaluate lubricants, monitor the consistency of die lubrication process, and obtain useful process data, such as surface temperature, heat flux, and heat transfer coefficients. The heat removed from the die surface during lubricant application is necessary for (a) designing the cooling channels in the die, i.e. their size and placement, and (b) performing accurate numerical simulations of the die casting process.

  18. The Energy-Dependent Position of the IBEX Ribbon Due to the Solar Wind Structure

    NASA Astrophysics Data System (ADS)

    Swaczyna, Paweł; Bzowski, Maciej; Sokół, Justyna M.

    2016-08-01

    Observations of energetic neutral atoms (ENAs) allow for remote studies of the condition of plasma in the heliosphere and the neighboring local interstellar medium. The first results from the Interstellar Boundary Explorer (IBEX) revealed an arc-like enhancement of the ENA intensity in the sky, known as the ribbon. The ribbon was not expected from the heliospheric models prior to the launch of IBEX. One proposed explanation for the ribbon is the mechanism of secondary ENA emission. The ribbon reveals energy-dependent structure in the relative intensity along its circumference and in its position. That is, the geometric center of the ribbon varies systematically by about 10° in the energy range 0.7–4.3 keV. Here, we show by analytical modeling that this effect is a consequence of the helio-latitudinal structure of the solar wind reflected in the secondary ENAs. Along with a recently measured distance to the ribbon’s source just beyond the heliopause, our findings support the connection of the ribbon with the local interstellar magnetic field by the mechanism of secondary ENA emission. However, the magnitude of the center shift in the highest IBEX energy channel is much larger in the observations than expected from the modeling. This may be due to another, not currently recognized, process of ENA generation.

  19. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins.

    PubMed

    Reig, Amanda J; Pires, Marcos M; Snyder, Rae Ana; Wu, Yibing; Jo, Hyunil; Kulp, Daniel W; Butch, Susan E; Calhoun, Jennifer R; Szyperski, Thomas; Szyperski, Thomas G; Solomon, Edward I; DeGrado, William F

    2012-11-01

    De novo proteins provide a unique opportunity to investigate the structure-function relationships of metalloproteins in a minimal, well-defined and controlled scaffold. Here, we describe the rational programming of function in a de novo designed di-iron carboxylate protein from the Due Ferri family. Originally created to catalyse the O(2)-dependent, two-electron oxidation of hydroquinones, the protein was reprogrammed to catalyse the selective N-hydroxylation of arylamines by remodelling the substrate access cavity and introducing a critical third His ligand to the metal-binding cavity. Additional second- and third-shell modifications were required to stabilize the His ligand in the core of the protein. These structural changes resulted in at least a 10(6)-fold increase in the relative rate between the arylamine N-hydroxylation and hydroquinone oxidation reactions. This result highlights the potential for using de novo proteins as scaffolds for future investigations of the geometric and electronic factors that influence the catalytic tuning of di-iron active sites. PMID:23089864

  20. Uncertainties in Eddy Covariance fluxes due to post-field data processing: a multi-site, full factorial analysis

    NASA Astrophysics Data System (ADS)

    Sabbatini, S.; Fratini, G.; Arriga, N.; Papale, D.

    2012-04-01

    Eddy Covariance (EC) is the only technologically available direct method to measure carbon and energy fluxes between ecosystems and atmosphere. However, uncertainties related to this method have not been exhaustively assessed yet, including those deriving from post-field data processing. The latter arise because there is no exact processing sequence established for any given situation, and the sequence itself is long and complex, with many processing steps and options available. However, the consistency and inter-comparability of flux estimates may be largely affected by the adoption of different processing sequences. The goal of our work is to quantify the uncertainty introduced in each processing step by the fact that different options are available, and to study how the overall uncertainty propagates throughout the processing sequence. We propose an easy-to-use methodology to assign a confidence level to the calculated fluxes of energy and mass, based on the adopted processing sequence, and on available information such as the EC system type (e.g. open vs. closed path), the climate and the ecosystem type. The proposed methodology synthesizes the results of a massive full-factorial experiment. We use one year of raw data from 15 European flux stations and process them so as to cover all possible combinations of the available options across a selection of the most relevant processing steps. The 15 sites have been selected to be representative of different ecosystems (forests, croplands and grasslands), climates (mediterranean, nordic, arid and humid) and instrumental setup (e.g. open vs. closed path). The software used for this analysis is EddyPro™ 3.0 (www.licor.com/eddypro). The critical processing steps, selected on the basis of the different options commonly used in the FLUXNET community, are: angle of attack correction; coordinate rotation; trend removal; time lag compensation; low- and high- frequency spectral correction; correction for air density

  1. Skyshine analysis using energy and angular dependent dose-contribution fluxes obtained from air-over-ground adjoint calculation.

    PubMed

    Uematsu, Mikio; Kurosawa, Masahiko

    2005-01-01

    A generalised and convenient skyshine dose analysis method has been developed based on forward-adjoint folding technique. In the method, the air penetration data were prepared by performing an adjoint DOT3.5 calculation with cylindrical air-over-ground geometry having an adjoint point source (importance of unit flux to dose rate at detection point) in the centre. The accuracy of the present method was certified by comparing with DOT3.5 forward calculation. The adjoint flux data can be used as generalised radiation skyshine data for all sorts of nuclear facilities. Moreover, the present method supplies plenty of energy-angular dependent contribution flux data, which will be useful for detailed shielding design of facilities. PMID:16604693

  2. Model-dependent high-energy neutrino flux from gamma-ray bursts.

    PubMed

    Zhang, Bing; Kumar, Pawan

    2013-03-22

    The IceCube Collaboration recently reported a stringent upper limit on the high energy neutrino flux from gamma-ray bursts (GRBs), which provides a meaningful constraint on the standard internal shock model. Recent broadband electromagnetic observations of GRBs also challenge the internal shock paradigm for GRBs, and some competing models for γ-ray prompt emission have been proposed. We describe a general scheme for calculating the GRB neutrino flux, and compare the predicted neutrino flux levels for different models. We point out that the current neutrino flux upper limit starts to constrain the standard internal shock model. The dissipative photosphere models are also challenged if the cosmic ray luminosity from GRBs is at least 10 times larger than the γ-ray luminosity. If the neutrino flux upper limit continues to go down in the next few years, then it would suggest the following possibilities: (i) the photon-to-proton luminosity ratio in GRBs is anomalously high for shocks, which may be achieved in some dissipative photosphere models and magnetic dissipation models; or (ii) the GRB emission site is at a larger radius than the internal shock radius, as expected in some magnetic dissipation models such as the internal collision-induced magnetic reconnection and turbulence model. PMID:25166786

  3. Mechanisms controlling the SST air-sea heat flux feedback and its dependence on spatial scale

    NASA Astrophysics Data System (ADS)

    Hausmann, Ute; Czaja, Arnaud; Marshall, John

    2016-05-01

    The turbulent air-sea heat flux feedback (α , in {W m}^{-2}{ K}^{-1} ) is a major contributor to setting the damping timescale of sea surface temperature (SST) anomalies. In this study we compare the spatial distribution and magnitude of α in the North Atlantic and the Southern Ocean, as estimated from the ERA-Interim reanalysis dataset. The comparison is rationalized in terms of an upper bound on the heat flux feedback, associated with "fast" atmospheric export of temperature and moisture anomalies away from the marine boundary layer, and a lower bound associated with "slow" export. It is found that regions of cold surface waters (≤ 10° C) are best described as approaching the slow export limit. This conclusion is not only valid at the synoptic scale resolved by the reanalysis data, but also on basin scales. In particular, it applies to the heat flux feedback acting as circumpolar SST anomaly scales are approached in the Southern Ocean, with feedbacks of ≤ 10 {W m}^{-2}{ K}^{-1} . In contrast, the magnitude of the heat flux feedback is close to that expected from the fast export limit over the Gulf Stream and its recirculation with values on the order of ≈40 {W m}^{-2}{ K}^{-1} . Further analysis suggests that this high value reflects a compensation between a moderate thermodynamic adjustment of the boundary layer, which tends to weaken the heat flux feedback, and an enhancement of the surface winds over warm SST anomalies, which tend to enhance the feedback.

  4. Relationships between cosmic ray neutron flux and rain flows in dependence on different latitudes and altitudes

    NASA Astrophysics Data System (ADS)

    Velinov, Peter; Velinov, Peter; Belov, Anatolii; Yanke, Viktor; Eroshenko, Evgenia; Mishev, Alexander; Tassev, Yordan

    A convenient tool for investigation of primary cosmic ray variations is the registration of secondary cosmic ray neutrons. A network of neutron monitors, aiming the studies of cosmic ray variations exists. At the same time cosmic ray variations may be related to some atmospheric processes. In this connection, using the data from Moskow neutron monitor (latitude 55 degree) and lead free neutron monitor at BEO Moussala (latitude 42 degree and latitude 2971 m above see level), we studied the correlations between rain flows and neutron flux. In this study we used daily averages on the basis of 10 min data for the neutron flux, corrected for barometric pressure and data for local meteo-stations. The measured data permitted to study such effect at different observation levels and latitudes. The preliminary studies permits to observe correlation between rain flows and neutron flux in several cases.

  5. Effect of high-flux H/He plasma exposure on tungsten damage due to transient heat loads

    NASA Astrophysics Data System (ADS)

    De Temmerman, G.; Morgan, T. W.; van Eden, G. G.; de Kruif, T.; Wirtz, M.; Matejicek, J.; Chraska, T.; Pitts, R. A.; Wright, G. M.

    2015-08-01

    The thermal shock behaviour of tungsten exposed to high-flux plasma is studied using a high-power laser. The cases of laser-only, sequential laser and hydrogen (H) plasma and simultaneous laser plus H plasma exposure are studied. H plasma exposure leads to an embrittlement of the material and the appearance of a crack network originating from the centre of the laser spot. Under simultaneous loading, significant surface melting is observed. In general, H plasma exposure lowers the heat flux parameter (FHF) for the onset of surface melting by ∼25%. In the case of He-modified (fuzzy) surfaces, strong surface deformations are observed already after 1000 laser pulses at moderate FHF = 19 MJ m-2 s-1/2, and a dense network of fine cracks is observed. These results indicate that high-fluence ITER-like plasma exposure influences the thermal shock properties of tungsten, lowering the permissible transient energy density beyond which macroscopic surface modifications begin to occur.

  6. Sputter roughening instability on the Ge(001) surface: Energy and flux dependence

    SciTech Connect

    Chason, E.; Mayer, T.M.; Kellerman, B.K.

    1995-12-31

    We have measured surface roughening kinetics during low energy Xe ion sputtering of Ge (001) surfaces. Results are interpreted in terms of an instability theory developed by Bradley and Harper. Although the calculated magnitude of the roughening rate does not agree with the measured value, the variation of the rate with ion flux and energy is on agreement with the theory.

  7. Development of a Detector to Measure the Angular Dependence of the Cosmic Ray Induced Neutron Background Flux at Ground Level

    SciTech Connect

    Morgan, J F; Gosnell, T B; Luke, S J; Archer, D E; Lochner, R T; Frank, I M; Prussin, S G; Quiter, B J; Chivers, D H

    2002-01-28

    The detection of low intensity sources of radiation in containers is of particular interest for arms control, non-proliferation and nuclear smuggling activities. Attempts to procure and smuggle nuclear materials that could be used in terrorist activities have been well documented in recent years. These incidents have included fissile materials such, as plutonium and uranium, as well as medical and industrial isotopes that could be used in a Radiation Dispersal Device. The vast majority of these incidents have been discovered through human intelligence work due to the difficulty of using radiation monitoring. The detection of radiation sources in well-shielded containers presents a difficult technological challenge. Few neutrons and gamma rays may escape from the container and these may be obscured by the naturally occurring background. The world in general is a radioactive environment. Many elements in the earth's crust, as well as in common plants and building materials, emit a constant stream of radiation. In fact the ultimate limit on the detection of hidden sources is often the background level at the location of interest. It has long been understood that knowledge of the directionality of this background can be used to improve the signal/noise ratio in detectors used for these measurements. Imaging detectors are one method of reducing the effect of the background, but this reduction comes at the expensive of a huge increase in detector complexity. Hence these systems, while important in some specific applications, are probably not suited for the deployment of many detectors over a large area. There may be another way of reducing the effect of backgrounds on monitoring measurements. This method consists of using knowledge of the directional dependence of the background flux to help reduce its effect on the detectors in question. An accurate knowledge of this angular distribution allows one to develop better shielding designs for the detectors.

  8. Photochemistry of solutes in/on ice: reaction rate dependence on sample orientation and photon flux

    NASA Astrophysics Data System (ADS)

    Hullar, T.; Anastasio, C.

    2015-12-01

    Particularly in polar regions, photochemical reactions in snowpacks can be an important mechanism for transforming organic and inorganic compounds. Chemicals within snow and ice are found in three different compartments: distributed in the bulk ice, concentrated in liquid-like regions (LLRs) within the ice matrix (such as at grain boundaries), or present in quasi-liquid layers (QLLs) at the air-ice interface. While some previous work suggested reaction rates may vary in these different compartments, our preliminary experiments found similar reaction rates in all three compartments, as well as in aqueous solution. Previous work also suggested reaction rate constants may be independent of photon flux under certain illumination conditions. Here, we extend our investigations to measure reaction rate constants in ice samples with different orientations to the illumination source, which our work thus far suggests may impact the measured rate constants. Polycyclic aromatic hydrocarbons (PAHs) are common pollutants in snow and ice. We first prepared aqueous solutions of a single PAH. We then froze these samples using various methods previously shown to segregate the solute into known locations in the ice matrix. With simulated polar sunlight, we illuminated these samples and measured photon flux (using 2-nitrobenzaldehyde as a chemical actinometer) and photodecay of the PAH. Using this information, we normalized the rate of PAH loss to the photon flux and calculated the rate constants for PAH photodegradation under various freezing conditions, photon fluxes, and sample orientations. We will report on the impact of these variables on PAH photodegradation as well as the effect of varying the photon flux.

  9. Numerical Study of Cattaneo-Christov Heat Flux Model for Viscoelastic Flow Due to an Exponentially Stretching Surface.

    PubMed

    Ahmad Khan, Junaid; Mustafa, M; Hayat, T; Alsaedi, A

    2015-01-01

    This work deals with the flow and heat transfer in upper-convected Maxwell fluid above an exponentially stretching surface. Cattaneo-Christov heat flux model is employed for the formulation of the energy equation. This model can predict the effects of thermal relaxation time on the boundary layer. Similarity approach is utilized to normalize the governing boundary layer equations. Local similarity solutions are achieved by shooting approach together with fourth-fifth-order Runge-Kutta integration technique and Newton's method. Our computations reveal that fluid temperature has inverse relationship with the thermal relaxation time. Further the fluid velocity is a decreasing function of the fluid relaxation time. A comparison of Fourier's law and the Cattaneo-Christov's law is also presented. Present attempt even in the case of Newtonian fluid is not yet available in the literature. PMID:26325426

  10. Numerical Study of Cattaneo-Christov Heat Flux Model for Viscoelastic Flow Due to an Exponentially Stretching Surface

    PubMed Central

    Ahmad Khan, Junaid; Mustafa, M.; Hayat, T.; Alsaedi, A.

    2015-01-01

    This work deals with the flow and heat transfer in upper-convected Maxwell fluid above an exponentially stretching surface. Cattaneo-Christov heat flux model is employed for the formulation of the energy equation. This model can predict the effects of thermal relaxation time on the boundary layer. Similarity approach is utilized to normalize the governing boundary layer equations. Local similarity solutions are achieved by shooting approach together with fourth-fifth-order Runge-Kutta integration technique and Newton’s method. Our computations reveal that fluid temperature has inverse relationship with the thermal relaxation time. Further the fluid velocity is a decreasing function of the fluid relaxation time. A comparison of Fourier’s law and the Cattaneo-Christov’s law is also presented. Present attempt even in the case of Newtonian fluid is not yet available in the literature. PMID:26325426

  11. Application of the 15N gas-flux method for measuring in situ N2 and N2O fluxes due to denitrification in natural and semi-natural terrestrial ecosystems and comparison with the acetylene inhibition technique

    NASA Astrophysics Data System (ADS)

    Sgouridis, Fotis; Stott, Andrew; Ullah, Sami

    2016-03-01

    Soil denitrification is considered the most un-constrained process in the global N cycle due to uncertain in situ N2 flux measurements, particularly in natural and semi-natural terrestrial ecosystems. 15N tracer approaches can provide in situ measurements of both N2 and N2O simultaneously, but their use has been limited to fertilized agro-ecosystems due to the need for large 15N additions in order to detect 15N2 production against the high atmospheric N2. For 15N-N2 analyses, we have used an "in-house" laboratory designed and manufactured N2 preparation instrument which can be interfaced to any commercial continuous flow isotope ratio mass spectrometer (CF-IRMS). The N2 prep unit has gas purification steps and a copper-based reduction furnace, and allows the analysis of small gas injection volumes (4 µL) for 15N-N2 analysis. For the analysis of N2O, an automated Tracegas Preconcentrator (Isoprime Ltd) coupled to an IRMS was used to measure the 15N-N2O (4 mL gas injection volume). Consequently, the coefficient of variation for the determination of isotope ratios for N2 in air and in standard N2O (0.5 ppm) was better than 0.5 %. The 15N gas-flux method was adapted for application in natural and semi-natural land use types (peatlands, forests, and grasslands) by lowering the 15N tracer application rate to 0.04-0.5 kg 15N ha-1. The minimum detectable flux rates were 4 µg N m-2 h-1 and 0.2 ng N m-2 h-1 for the N2 and N2O fluxes respectively. Total denitrification rates measured by the acetylene inhibition technique in the same land use types correlated (r = 0.58) with the denitrification rates measured under the 15N gas-flux method, but were underestimated by a factor of 4, and this was partially attributed to the incomplete inhibition of N2O reduction to N2, under a relatively high soil moisture content, and/or the catalytic NO decomposition in the presence of acetylene. Even though relatively robust for in situ denitrification measurements, methodological

  12. Generation of the cosmic rays flux variations due to surfatron acceleration of charges by electromagnetic waves in space plasma

    NASA Astrophysics Data System (ADS)

    Erokhin, Nikolay; Loznikov, Vladimir; Shkevov, Rumen; Zolnikova, Nadezhda; Mikhailovskaya, Ludmila

    2016-07-01

    The analysis of experimental data on the spectra of cosmic rays (CR) has shown their variability on time scales of a few years, in particular, CR variations observed in E / Z range from TeV to 10000 TeV, where E is the energy of the particle, Z is its charge number. Consequently, the source of these variations must be located at a distance of no more than 1 parsec from the sun in the closest local interstellar clouds. As a mechanism of such variations appearance it is considered the surfatron acceleration of CR particles by electromagnetic wave in a relatively quiet space plasma. On the basis of developed model the numerical calculations were performed for particle capture dynamics (electrons, protons, helium and iron nuclei) in the wave effective potential well with a following growth their energy by 3-6 orders of magnitude. Optimal conditions for the implementation of charged particles surfatron acceleration in space plasma, the rate of trapped particles energy growth, the dynamics of wave phase on the captured particle trajectory, a temporal dynamics of components for charge impulse momentum and speed were studied. It is indicated that the capture of a small fraction of particles by wave for energies about TeV and less followed by their surfatron acceleration to an energy of about 10000 TeV will lead to a significant increase in the CR flux at such high energies. Thus CL flow variations are conditioned by changes in the space weather parameters

  13. Application of the 15N-Gas Flux method for measuring in situ N2 and N2O fluxes due to denitrification in natural and semi-natural terrestrial ecosystems and comparison with the acetylene inhibition technique

    NASA Astrophysics Data System (ADS)

    Sgouridis, F.; Ullah, S.; Stott, A.

    2015-08-01

    Soil denitrification is considered the most un-constrained process in the global N cycle due to uncertain in situ N2 flux measurements, particularly in natural and semi-natural terrestrial ecosystems. 15N tracer approaches can provide in situ measurements of both N2 and N2O simultaneously, but their use has been limited to fertilised agro-ecosystems due to the need for large 15N additions in order to detect 15N2 production against the high atmospheric N2. For 15N-N2 analyses, we have used an "in house" laboratory designed and manufactured N2 preparation instrument which can be interfaced to any commercial continuous flow isotope ratio mass spectrometer (CF-IRMS). The N2 prep unit has gas purification steps, a copper based reduction furnace, and allows the analysis of small gas injection volumes (4 μL) for 15N-N2 analysis. For the analysis of N2O, an automated Tracegas Pre-concentrator (Isoprime Ltd) coupled to an IRMS was used to measure the 15N-N2O (4 mL gas injection volume). Consequently, the coefficient of variation for the determination of isotope ratios for N2 in air and in standard N2O (0.5 ppm) was better than 0.5 %. The 15N Gas-Flux method was adapted for application in natural and semi-natural land use types (peatlands, forests and grasslands) by lowering the 15N tracer application rate to 0.04-0.5 kg 15N ha-1. For our chamber design (volume / surface = 8:1) and a 20 h incubation period, the minimum detectable flux rates were 4 μg N m-2 h-1 and 0.2 ng N m-2 h-1 for the N2 and N2O fluxes respectively. The N2 flux ranged between 2.4 and 416.6 μg N m-2 h-1, and the grassland soils showed on average 3 and 14 times higher denitrification rates than the woodland and organic soils respectively. The N2O flux was on average 20 to 200 times lower than the N2 flux, while the denitrification product ratio (N2O/N2 + N2O) was low, ranging between 0.03 and 13 %. Total denitrification rates measured by the acetylene inhibition technique under the same field conditions

  14. Gravity wave activity in the thermosphere inferred from GOCE data, and its dependence on solar flux conditions.

    NASA Astrophysics Data System (ADS)

    Garcia, Raphael F.; Bruinsma, Sean; Doornbos, Eelco; Massarweh, Lotfi

    2016-04-01

    This study is focused on the effect of solar flux conditions on the dynamics of Gravity Waves (GW) in thermosphere. Air density and cross-wind in situ estimates from the Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) accelerometers are analyzed for the whole mission duration. The analysis was performed in the Fourier spectral domain averaging spectral results over periods of 2 months close to solstices. First the Amplitude Spectral Density (ASD) and the Magnitude Squared Coherence (MSC) of physical parameters are linked to local gravity waves. Then, a new GW marker (called Cf3) was introduced here to constrain GWs activity under Low, Medium and High solar flux conditions, showing a clear solar dumping effect on GW activity. Most of GW signal has been found in a spectral range above 8 mHz in GOCE data, meaning a maximum horizontal wavelength around 1000 km. The level GW activity at GOCE altitude is strongly decreasing with increasing solar flux. Furthermore, a shift in the dominant frequency with solar flux conditions has been noted, leading to a larger horizontal wavelengths (from 200 to 500 km) during high solar flux conditions. The influence of correlated error sources, between air density and cross-winds, is discussed. Consistency of the spectral domain results has been verified in time-domain with a global mapping of high frequency perturbations along GOCE orbit. This analysis shows a clear dependence with geomagnetic latitude with strong perturbations at magnetic poles, and an extension to lower latitudes favoured by low solar activity conditions. Various possible causes of this spatial trend are discussed.

  15. Thermal ion upflow in the cusp ionosphere and its dependence on soft electron energy flux

    NASA Astrophysics Data System (ADS)

    Burchill, J. K.; Knudsen, D. J.; Clemmons, J. H.; Oksavik, K.; Pfaff, R. F.; Steigies, C. T.; Yau, A. W.; Yeoman, T. K.

    2010-05-01

    We investigate the origin of low-energy (Ek < 10 eV) ion upflows in Earth's low-altitude dayside cusp region. The Cusp-2002 sounding rocket flew from Ny Ålesund, Svalbard, on 14 December 2002, carrying plasma and field instrumentation to an altitude of 768 km. The Suprathermal Ion Imager, a two-dimensional energy/arrival angle spectrograph, observed large (>500 m s-1) ion upflows within the cusp at altitudes between 640 km and 768 km. We report a significant correlation between ion upflow and precipitating magnetosheath electron energy flux in this altitude range. There is only very weak correlation between upflow and wave power in the VLF band. We find a small negative correlation between upflow and the magnitude of the DC electric field for fields less than about 70 mV m-1. The apparent relation between upflow and electron energy flux suggests a mechanism whereby ions are accelerated by parallel electric fields that are established by the soft electrons. Significant ion upflows are not observed for electron energy fluxes less than about 1010 eV cm-2 s-1. The lack of correspondence between ∣$\\vec{E∣ and upflow on the one hand, and wave power and upflow on the other, does not rule out these processes but implies that, if operating, they are not local to the measurement region. We also observe narrow regions of large ion downflow that imply either a rebalancing of the ionosphere toward a low-Te equilibrium during which gravity dominates over the pressure gradients or a convection of the upflowing ions away from the precipitation region, outside of which the ions must fall back into equilibrium at lower altitudes.

  16. Ion Outflow in the Dayside Cusp Ionosphere and its Dependence on Soft Electron Energy Flux

    NASA Astrophysics Data System (ADS)

    Burchill, J. K.; Knudsen, D. J.; Clemmons, J. H.; Oksavik, K.; Pfaff, R. F.; Steigies, C. T.; Yau, A. W.; Yeoman, T. K.

    2009-12-01

    We investigate the origin of low energy (Ek<10 eV) ion upflows in Earth's low-altitude dayside cusp region. The Cusp-2002 sounding rocket flew from Ny Ålesund, Svalbard, on 14 December 2002, carrying plasma and field instrumentation to an altitude of 768 km. The Suprathermal Ion Imager, a two-dimensional energy/arrival-angle spectrograph, observed large (>500 m/s) O+ upflows within the cusp at altitudes between 640 km and 768 km. We report a significant association between ion upflow and precipitating magnetosheath electron energy flux in this altitude range, but no causal links between upflow and either wave power or the magnitude of the dc electric field. The correspondence between upflow and logarithm of the electron energy flux suggests a mechanism whereby ions are accelerated locally by ambipolar electric fields that are driven by the soft electrons. Significant ion upflows are not observed for electron energy fluxes below ˜1010 eV cm-2s-1, which suggests that any ambipolar fields present above 640 km must be in equilibrium with gravity and pressure gradients under this condition. The lack of correspondence between │E│ and upflow on the one hand, and wave power and upflow on the other, does not rule out these processes, but implies that, if operating, they are not local to the measurement region. We observe narrow regions of large downflow that imply either a re-balancing of the ionosphere toward a low-Te equilibrium during which gravity dominates the pressure gradients, or convection of the upflowing ions away from the precipitation region, outside of which the ions must fall back into equilibrium at lower altitudes.

  17. Linear MHD Wave Propagation in Time-Dependent Flux Tube. II. Finite Plasma Beta

    NASA Astrophysics Data System (ADS)

    Williamson, A.; Erdélyi, R.

    2014-04-01

    The propagation of magnetohydrodynamic (MHD) waves is an area that has been thoroughly studied for idealised static and steady state magnetised plasma systems applied to numerous solar structures. By applying the generalisation of a temporally varying background density to an open magnetic flux tube, mimicking the observed slow evolution of such waveguides in the solar atmosphere, further investigations into the propagation of both fast and slow MHD waves can take place. The assumption of a zero-beta plasma (no gas pressure) was applied in Williamson and Erdélyi ( Solar Phys. 2013, doi:10.1007/s11207-013-0366-9, Paper I) is now relaxed for further analysis here. Firstly, the introduction of a finite thermal pressure to the magnetic flux tube equilibrium modifies the existence of fast MHD waves which are directly comparable to their counterparts found in Paper I. Further, as a direct consequence of the non-zero kinetic plasma pressure, a slow MHD wave now exists, and is investigated. Analysis of the slow wave shows that, similar to the fast MHD wave, wave amplitude amplification takes place in time and height. The evolution of the wave amplitude is determined here analytically. We conclude that for a temporally slowly decreasing background density both propagating magnetosonic wave modes are amplified for over-dense magnetic flux tubes. This information can be very practical and useful for future solar magneto-seismology applications in the study of the amplitude and frequency properties of MHD waveguides, e.g. for diagnostic purposes, present in the solar atmosphere.

  18. The Modification of Time-Dependent Mechanical Properties of Polyamides due to Sterilization

    NASA Astrophysics Data System (ADS)

    Florjancic, Urska; Zupancic, Barbara; Sutton, Elizabeth; Sitar, Ksenija Rener; Marion, Ljubo; Batista, Urska; Groselj, Dusan; Emri, Igor

    2008-07-01

    We examine the effect of sterilization on functionality and durability of Polyamide 6. Nowadays there are several applications of this material in medicine in a form of surgical sewing material, vascular catheters and other implants. Understanding the time-dependent behavior of PA-6 is critical in predicting the durability of different medical products made from this polymer. We show that two PA-6 materials having different initial kinetics and processed with the same technology, when exposed to sterilization, change their time-dependent mechanical properties, and hence the durability in significantly different ways.

  19. Observation of sudden temperature jumps in optically levitated microdroplets due to morphology-dependent input resonances.

    PubMed

    Popp, J; Lankers, M; Schaschek, K; Kiefer, W; Hodges, J T

    1995-05-01

    During the slow evaporation of an optically levitated microdroplet of a glycerol-water mixture (3:1) (approximately 12.44 µm in radius) several morphology-dependent input resonances have been observed in its Raman spectrum. These resonances yield sudden temperature jumps of approximately 10 °C in the microdroplet as evidenced by sudden shifts in the output (Raman) resonance spectra. The latter effects could be explained by a simple energy balance calculation and the dependence of droplet refractive index and density on temperature. PMID:21037793

  20. Morphology-dependent water budgets and nutrient fluxes in arctic thaw ponds

    USGS Publications Warehouse

    Koch, Joshua C.; Gurney, Kirsty; Wipfli, Mark S.

    2014-01-01

    Thaw ponds on the Arctic Coastal Plain of Alaska are productive ecosystems, providing habitat and food resources for many fish and bird species. Permafrost in this region creates unique pond morphologies: deep troughs, shallow low-centred polygons (LCPs) and larger coalescent ponds. By monitoring seasonal trends in pond volume and chemistry, we evaluated whether pond morphology and size affect water temperature and desiccation, and nitrogen (N) and phosphorus (P) fluxes. Evaporation was the largest early-summer water flux in all pond types. LCPs dried quickly and displayed high early-summer nutrient concentrations and losses. Troughs consistently received solute-rich subsurface inflows, which accounted for 12 to 42 per cent of their volume and may explain higher P in the troughs. N to P ratios increased and ammonium concentrations decreased with pond volume, suggesting that P and inorganic N availability may limit ecosystem productivity in older, larger ponds. Arctic summer temperatures will likely increase in the future, which may accelerate mid-summer desiccation. Given their morphology, troughs may remain wet, become warmer and derive greater nutrient loads from their thawing banks. Overall, seasonal- to decadal-scale warming may increase ecosystem productivity in troughs relative to other Arctic Coastal Plain ponds. 

  1. Flux-Dependent Growth Kinetics and Diameter Selectivity in Single-Wall Carbon Nanotube Arrays

    SciTech Connect

    Geohegan, David B; Puretzky, Alexander A; Jackson, Jeremy Joseph; Rouleau, Christopher M; Eres, Gyula; More, Karren Leslie

    2011-01-01

    The nucleation and growth kinetics of single-wall carbon nanotubes in aligned arrays have been measured using fast pulses of acetylene and in situ optical diagnostics in conjunction with low pressure chemical vapor deposition (CVD). Increasing the acetylene partial pressure is shown to decrease nucleation times by three orders of magnitude, permitting aligned nanotube arrays to nucleate and grow to microns lengths within single gas pulses at high (up to 7 micron/s) peak growth rates and short ~ 0.5 s times.Low-frequency Raman scattering (> 10 cm-1) and transmission electron microscopy measurements show that increasing the feedstock flux in both continuous-CVD and pulsed-CVD shifts the product distribution to large single-wall carbon nanotube diameters > 2.5 nm. Sufficiently high acetylene partial pressures in pulsed-CVD appear to temporarily terminate the growth of the fastest- growing, small-diameter nanotubes by overcoating the more catalytically-active, smaller catalyst nanoparticles within the ensemble with non-nanotube carbon in agreement with a growth model. The results indicate that subsets of catalyst nanoparticle ensembles nucleate, grow, and terminate growth within different flux ranges according to their catalytic activity.

  2. Role of native defects in nitrogen flux dependent carrier concentration of InN films grown by molecular beam epitaxy

    SciTech Connect

    Tangi, Malleswararao; Kuyyalil, Jithesh; Shivaprasad, S. M.

    2012-10-01

    We address the carrier concentration, strain, and bandgap issue of InN films grown on c-sapphire at different N-flux by molecular beam epitaxy using x-ray diffraction and x-ray photoelectron spectroscopy. We demonstrate that the strain in InN films arises due to point defects like nitrogen interstitials and nitrogen antisites. We report minimal biaxial strain due to relaxed growth morphology and a minimal hydrostatic strain arising due to interstitial nitrogen atoms being partially compensated by nitrogen antisites. We find that the variation in absorption edge can be attributed to defect induced carrier concentration and that nitrogen interstitials and nitrogen antisites act as donors that yield the respective absorption edge and Moss-Burstein shift. Our studies are a step towards the ability to form low carrier concentration strain-relaxed films and to determine the intrinsic band gap value for this technologically important material.

  3. Self-healing slip pulses in dynamic rupture models due to velocity-dependent strength

    USGS Publications Warehouse

    Beeler, N.M.; Tullis, T.E.

    1996-01-01

    Seismological observations of short slip duration on faults (short rise time on seismograms) during earthquakes are not consistent with conventional crack models of dynamic rupture and fault slip. In these models, the leading edge of rupture stops only when a strong region is encountered, and slip at an interior point ceases only when waves from the stopped edge of slip propagate back to that point. In contrast, some seismological evidence suggests that the duration of slip is too short for waves to propagate from the nearest edge of the ruptured surface, perhaps even if the distance used is an asperity size instead of the entire rupture dimension. What controls slip duration, if not dimensions of the fault or of asperities? In this study, dynamic earthquake rupture and slip are represented by a propagating shear crack. For all propagating shear cracks, slip velocity is highest near the rupture front, and at a small distance behind the rupture front, the slip velocity decreases. As pointed out by Heaton (1990), if the crack obeys a negative slip-rate-dependent strength relation, the lower slip velocity behind the rupture front will lead to strengthening that further reduces the velocity, and under certain circumstances, healing of slip can occur. The boundary element method of Hamano (1974) is used in a program adapted from Andrews (1985) for numerical simulations of mode II rupture with two different velocity-dependent strength functions. For the first function, after a slip-weakening displacement, the crack follows an exponential velocity-weakening relation. The characteristic velocity V0 of the exponential determines the magnitude of the velocity-dependence at dynamic velocities. The velocity-dependence at high velocity is essentially zero when V0 is small and the resulting slip velocity distribution is similar to slip weakening. If V0 is larger, rupture propagation initially resembles slip-weakening, but spontaneous healing occurs behind the rupture front. The

  4. Simulating Damage Due to a Lightning Strike Event: Effects of Temperature Dependent Properties on Interlaminar Damage

    NASA Technical Reports Server (NTRS)

    Ghezeljeh, Paria Naghipour; Pineda, Evan Jorge

    2014-01-01

    A multidirectional, carbon fiber-epoxy, composite panel is subjected to a simulated lightning strike, within a finite element method framework, and the effect of material properties on the failure (delamination) response is investigated through a detailed numerical study. The numerical model of the composite panel consists of individual homogenized plies with user-defined, cohesive interface elements between them. Lightning strikes are simulated as an assumed combination of excessive heat and high pressure loadings. It is observed that the initiation and propagation of lightning-induced delamination is a significant function of the temperature dependency of interfacial fracture toughness. This dependency must be defined properly in order to achieve reliable predictions of the present lightning-induced delamination in the composite panel.

  5. Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes

    PubMed Central

    Raffel, A; Anlauf, M; Hosch, SB; Krausch, M; Henopp, T; Bauersfeld, J; Klofat, R; Bach, D; Eisenberger, CF; Klöppel, G; Knoefel, WT

    2006-01-01

    In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered. PMID:17131493

  6. Direct Evidence for Projectile Charge-State Dependent Crater Formation Due to Fast Ions

    SciTech Connect

    Papaleo, R. M.; Silva, M. R.; Leal, R.; Grande, P. L.; Roth, M.; Schattat, B.; Schiwietz, G.

    2008-10-17

    We report on craters formed by individual 3 MeV/u Au{sup q{sub i}{sub n}{sub i}{sup +}} ions of selected incident charge states q{sub ini} penetrating thin layers of poly(methyl methacrylate). Holes and raised regions are formed around the region of the impact, with sizes that depend strongly and differently on q{sub ini}. Variation of q{sub ini}, of the film thickness and of the angle of incidence allows us to extract information about the depth of origin contributing to different crater features.

  7. Observations of the scale-dependent turbulence and evaluation of the flux-gradient relationship for sensible heat for a closed Douglas-Fir canopy in very weak wind conditions

    DOE PAGESBeta

    Vickers, D.; Thomas, C.

    2014-05-13

    Observations of the scale-dependent turbulent fluxes and variances above, within and beneath a tall closed Douglas-Fir canopy in very weak winds are examined. The daytime subcanopy vertical velocity spectra exhibit a double-peak structure with peaks at time scales of 0.8 s and 51.2 s. A double-peak structure is also observed in the daytime subcanopy heat flux cospectra. The daytime momentum flux cospectra inside the canopy and in the subcanopy are characterized by a relatively large cross-wind component, likely due to the extremely light and variable winds, such that the definition of a mean wind direction, and subsequent partitioning of themore » momentum flux into along- and cross-wind components, has little physical meaning. Positive values of both momentum flux components in the subcanopy contribute to upward transfer of momentum, consistent with the observed mean wind speed profile. In the canopy at night at the smallest resolved scales, we find relatively large momentum fluxes (compared to at larger scales), and increasing vertical velocity variance with decreasing time scale, consistent with very small eddies likely generated by wake shedding from the canopy elements that transport momentum but not heat. We find unusually large values of the velocity aspect ratio within the canopy, consistent with enhanced suppression of the horizontal wind components compared to the vertical by the canopy. The flux-gradient approach for sensible heat flux is found to be valid for the subcanopy and above-canopy layers when considered separately; however, single source approaches that ignore the canopy fail because they make the heat flux appear to be counter-gradient when in fact it is aligned with the local temperature gradient in both the subcanopy and above-canopy layers. Modeled sensible heat fluxes above dark warm closed canopies are likely underestimated using typical values of the Stanton number.« less

  8. The neurophysiological index of visual working memory maintenance is not due to load dependent eye movements.

    PubMed

    Kang, Min-Suk; Woodman, Geoffrey F

    2014-04-01

    The Contralateral Delayed Activity (CDA) is slow negative potential found during a variety of tasks, providing an important measure of the representation of information in visual working memory. However, it is studied using stimulus arrays in which the to-be-remembered objects are shown in the periphery of the left or the right visual field. Our goal was to determine whether fixational eye movements in the direction of the memoranda might underlie the CDA. We found that subjects' gaze was shifted toward the visual field of the memoranda during the retention interval, with its magnitude increasing with the set size. However, the CDA was clearly observed even when the subjects' gaze shifts were absent. In addition, the magnitude of the subjects' gaze shifts was unrelated to their visual working memory capacity measured with behavioral data, unlike the CDA. Finally, the onset latency of the set size dependent eye movements followed the onset of the set size dependent CDA. Thus, our findings clearly show that the CDA does not represent a simple inability to maintain fixation during visual working memory maintenance, but that this neural index of representation in working memory appears to induce eye movements toward the locations of the objects being remembered. PMID:24440409

  9. Enhanced momentum delivery by electric force to an ion flux due to collisions of ions with neutrals

    NASA Astrophysics Data System (ADS)

    Fruchtman, Amnon

    2014-10-01

    A major figure of merit in propulsion in general and in electric propulsion in particular is the thrust per unit of deposited power, the ratio of thrust over power. We have recently demonstrated experimentally and theoretically [1--4] that for a fixed deposited power in the ions, the momentum delivered by the electric force is larger if the accelerated ions collide with neutrals during the acceleration. The higher thrust for given power is achieved for a collisional plasma at the expense of a lower thrust per unit mass flow rate, reflecting what is true in general, that the lower the flow velocity is, the higher the thrust for a given power. This is the usual trade-off between having a large specific impulse and a large thrust. Broadening the range of jet velocities and thrust levels is desirable since there are different propulsion requirements for different space missions. The mechanism of thrust enhancement by ion-neutral collisions has been investigated in the past in the case of electric pressure, what is called ionic wind. I will describe in the talk experimental results for an enhanced thrust due to ion-neutral collisions in a configuration where the thrust is a result of magnetic pressure [1,3]. The plasma is accelerated by J × B force, in a configuration similar to that of Hall thrusters. Our measurements for three different gases and for various gas flow rates and magnetic field intensities, confirmed that the thrust increase is proportional to the square-root of the number of ion-neutral collisions. Additional measurements of local discharge parameters will be shown to be consistent with the force measurements. Issues that are crucial for the use of this mechanism in an electric thruster will also be discussed. These are the possible increase of the electron transport across magnetic field lines by electron-neutral collisions, and the possible effect on various sources of inefficiency. Supported by Grant No. 765/11 from the Israel Science Foundation.

  10. The Goddard Satellite-based Surface Turbulent Fluxes (GSSTF) Datasets and the Uncertainties/Impact due to the SSM/I Brightness Temperature

    NASA Astrophysics Data System (ADS)

    Shie, C.; Hilburn, K. A.

    2011-12-01

    Accurate ocean surface turbulent flux measurements are crucial to understanding the global water and energy cycle changes. Remote sensing is a valuable tool for global monitoring of these flux measurements. The GSSTF algorithm was thus developed and applied to remote sensing research and applications. The early version GSSTF2 (a global 1°x1° daily dataset of July 1987-December 2000) was widely used by the scientific community for global energy and water cycle research, and regional and short period data analysis since its official release in 2001. In a recently funded project by the NASA/Making Earth System data records for Use in Research Environments (MEaSUREs) Program, a new version GSSTF2b (a global 1°x1° daily dataset of July 1987-December 2008) using the improved and upgraded input datasets that included the updated Special Sensor Microwave Imagers (SSM/I) V6 product (e.g., brightness temperature [TB]) and the NCEP-DOE Reanalysis II product (e.g., sea surface/skin temperature) was therefore produced and distributed in October 2010. GSSTF2b was found to generally agree better with the sounding observations than GSSTF2 did in all three components of fluxes, i.e., latent heat flux (LHF), sensible heat flux (SHF), and wind stress (WST). In a recent intercomparison study led by one of the GSSTF2b/GSSTF2 users, GSSTF2b was also found performed well, especially in LHF and SHF, among the eleven accessed global oceanic surface turbulent fluxes datasets that include six reanalysis, four satellite-derived, and one combined. Certain foremost climate and weather scenarios such as the ENSO and the Monsoon activities can also be genuinely demonstrated by the GSSTF2b fluxes. However, we recently realized that the gradually increasing temporal trend shown in the globally averaged LHF of GSSTF2b, especially post 2000~2001, was somewhat related to a trend found in the SSM/I TB that was used to retrieve the bottom layer precipitable water (WB), then the specific humidity (Qa

  11. Passive trapping of rigid rods due to conformation-dependent electrophoretic mobility.

    PubMed

    Pandey, Harsh; Szafran, Sylvia A; Underhill, Patrick T

    2016-03-16

    We present computer simulations of a rigid rod in a combination of an extensional fluid flow and extensional electric field. The electrophoretic mobility of the rod is different parallel or perpendicular to the rod. The dependence of the mobility on the conformation (orientation) leads to a new phenomenon where the rods can be passively trapped in all directions at the stagnation point. This contrasts with the behavior in either fluid flow or electric field alone, in which an object can be pushed towards the stagnation point along some directions but is pushed away in others. We have determined the state space where trapping occurs and have developed a model that describes the strength of trapping when it does occur. This new phenomenon could be used in the future to separate objects based on a coupling between their mobility and ability to be oriented. PMID:26892384

  12. Enhancement of microbial motility due to speed-dependent nutrient absorption.

    PubMed

    Di Salvo, Mario E; Condat, C A

    2014-02-01

    Marine microorganisms often reach high swimming speeds, either to take advantage of evanescent nutrient patches or to beat Brownian forces. Since this implies that a sizable part of their energetic budget must be allocated to motion, it is reasonable to assume that some fast-swimming microorganisms may increase their nutrient intake by increasing their speed v. We formulate a model to investigate this hypothesis and its consequences, finding the steady-state solutions and analyzing their stability. Surprisingly, we find that even modest increases in nutrient absorption may lead to a significant increase of the microbial speed. In fact, evaluations obtained using realistic parameter values for bacteria indicate that the speed increase due to the enhanced nutrient absorption may be quite large. PMID:24451235

  13. Model predictions of latitude-dependent ozone depletion due to aerospace vehicle operations

    NASA Technical Reports Server (NTRS)

    Borucki, W. J.; Whitten, R. C.; Watson, V. R.; Riegel, C. A.; Maples, A. L.; Capone, L. A.

    1976-01-01

    Results are presented from a two-dimensional model of the stratosphere that simulates the seasonal movement of ozone by both wind and eddy transport, and contains all the chemistry known to be important. The calculated reductions in ozone due to NO2 injection from a fleet of supersonic transports are compared with the zonally averaged results of a three-dimensional model for a similar episode of injection. The agreement is good in the northern hemisphere, but is not as good in the southern hemisphere. Both sets of calculations show a strong corridor effect in that the predicted ozone depletions are largest to the north of the flight corridor for aircraft operating in the northern hemisphere.

  14. Model predictions of latitude-dependent ozone depletion due to supersonic transport operations

    NASA Technical Reports Server (NTRS)

    Borucki, W. J.; Whitten, R. C.; Watson, V. R.; Woodward, H. T.; Riegel, C. A.; Capone, L. A.; Becker, T.

    1976-01-01

    Results are presented from a two-dimensional model of the stratosphere that simulates the seasonal movement of ozone by both wind and eddy transport, and contains all the chemistry known to be important. The calculated reductions in ozone due to NO2 injection from a fleet of supersonic transports are compared with the zonally averaged results of a three-dimensional model for a similar episode of injection. The agreement is good in the northern hemisphere, but is not as good in the southern hemisphere. Both sets of calculations show a strong corridor effect in that the predicted ozone depletions are largest to the north of the flight corridor for aircraft operating in the northern hemisphere.

  15. Underestimating extreme events in power-law behavior due to machine-dependent cutoffs

    NASA Astrophysics Data System (ADS)

    Radicchi, Filippo

    2014-11-01

    Power-law distributions are typical macroscopic features occurring in almost all complex systems observable in nature. As a result, researchers in quantitative analyses must often generate random synthetic variates obeying power-law distributions. The task is usually performed through standard methods that map uniform random variates into the desired probability space. Whereas all these algorithms are theoretically solid, in this paper we show that they are subject to severe machine-dependent limitations. As a result, two dramatic consequences arise: (i) the sampling in the tail of the distribution is not random but deterministic; (ii) the moments of the sample distribution, which are theoretically expected to diverge as functions of the sample sizes, converge instead to finite values. We provide quantitative indications for the range of distribution parameters that can be safely handled by standard libraries used in computational analyses. Whereas our findings indicate possible reinterpretations of numerical results obtained through flawed sampling methodologies, they also pave the way for the search for a concrete solution to this central issue shared by all quantitative sciences dealing with complexity.

  16. Mitigation of Angle Tracking Errors Due to Color Dependent Centroid Shifts in SIM-Lite

    NASA Technical Reports Server (NTRS)

    Nemati, Bijan; An, Xin; Goullioud, Renaud; Shao, Michael; Shen, Tsae-Pyng; Wehmeier, Udo J.; Weilert, Mark A.; Wang, Xu; Werne, Thomas A.; Wu, Janet P.; Zhai, Chengxing

    2010-01-01

    The SIM-Lite astrometric interferometer will search for Earth-size planets in the habitable zones of nearby stars. In this search the interferometer will monitor the astrometric position of candidate stars relative to nearby reference stars over the course of a 5 year mission. The elemental measurement is the angle between a target star and a reference star. This is a two-step process, in which the interferometer will each time need to use its controllable optics to align the starlight in the two arms with each other and with the metrology beams. The sensor for this alignment is an angle tracking CCD camera. Various constraints in the design of the camera subject it to systematic alignment errors when observing a star of one spectrum compared with a start of a different spectrum. This effect is called a Color Dependent Centroid Shift (CDCS) and has been studied extensively with SIM-Lite's SCDU testbed. Here we describe results from the simulation and testing of this error in the SCDU testbed, as well as effective ways that it can be reduced to acceptable levels.

  17. The velocity dependence of X-ray emission due to Charge Exchange in the Cygnus Loop

    NASA Astrophysics Data System (ADS)

    Cumbee, Renata; Lyons, David; Mullen, Patrick Dean; Shelton, Robin L.; Stancil, Phillip C.; Schultz, David R.

    2016-01-01

    The fundamental collisional process of charge exchange (CX) has been been established as a primary source of X-ray emission from the heliosphere [1], planetary exospheres [2], and supernova remnants [3,4]. In this process, X-ray emission results from the capture of an electron by a highly charged ion from a neutral atom or molecule, to form a highly-excited, high charge state ion. As the captured electron cascades down to the lowest energy level, photons are emitted, including X-rays.To provide reliable CX-induced X-ray spectral models to realistically simulate these environments, line ratios and spectra are computed using theoretical CX cross-sections obtained with the multi-channel Landau-Zener, atomic-orbital close-coupling, and classical-trajectory Monte Carlo methods for various collisional velocities relevant to astrophysics for collisions of bare and H-like C to Al ions with H, He, and H2. Using these line ratios, XSPEC models of CX emission in the northeast rim of the Cygnus Loop supernova remnant will be shown as an example with ion velocity dependence.[1] Henley, D. B. & Shelton, R. L. 2010, ApJSS, 187, 388[2] Dennerl, K. et al. 2002, A&A 386, 319[3] Katsuda, S. et al. 2011, ApJ 730 24[4] Cumbee, R. S. et al. 2014, ApJ 787 L31This work was partially supported by NASA grant NNX09AC46G.

  18. Estimated Overturning of Internal Waves due to Time-Dependent Shear in the Ocean

    NASA Astrophysics Data System (ADS)

    Latorre, Leonardo; Vanderhoff, Julie

    2010-11-01

    The ocean and atmosphere have a particular characteristic that sustains propagation of internal gravity waves called a stable stratification. Internal waves are generated, with wavelengths which can vary from a few meters to kilometers. These waves propagate through the ocean and atmosphere exchanging energy and momentum as they interact with other fluid phenomena and break, which in turn affects circulation, heat transport, nutrient distribution and biological activity in the oceans and the atmosphere. However large scale circulation models lack the appropriate resolution to detect these motions, hence it is necessary to accurately parameterize internal wave breaking in order to establish a better relationship between wave energy dissipation and its effects on oceanic and atmospheric circulation patterns. In this research internal waves interact with a time dependent background in the form of a near-inertial wave, which are common in the ocean. Using a two dimensional, fully non-linear Navier-Stokes equation solver and ray theory, estimates of wave breaking parameters which predict breaking at the same location in both of these models are accomplished. A statistical analysis of waves observed during the Hawaiian Ocean Mixing Experiment will provide an estimate of the percentage of waves expected to break during propagation through an inertial wave.

  19. Flux-dependent percolation transition in immiscible two-phase flows in porous media.

    PubMed

    Ramstad, Thomas; Hansen, Alex; Oren, Pål-Eric

    2009-03-01

    Using numerical simulations, we study immiscible two-phase flow in a pore network reconstructed from Berea sandstone under flow conditions that are statistically invariant under translation. Under such conditions, the flow is a state function which is not dependent on initial conditions. We find a second-order phase transition resembling the phase inversion transition found in emulsions. The flow regimes under consideration are those of low surface tension-hence high capillary numbers Ca-where viscous forces dominate. Nevertheless, capillary forces are imminent, we observe a critical stage in saturation where the transition takes place. We determine polydispersity critical exponent tau=2.27+/-0.08 and find that the critical saturation depends on how fast the fluids flow. PMID:19392052

  20. Rubidium beam flux dependence of film properties of Ba1 - xRbxBiO3 deposited by molecular-beam epitaxy using distilled ozone

    NASA Astrophysics Data System (ADS)

    Ogihara, M.; Toda, F.; Makita, T.; Abe, H.

    1993-10-01

    We have focused our attention on the dependence of Ba1-xRbxBiO3 (BRBO) film composition ratio and film properties on rubidium-beam-flux intensity. BRBO films were deposited on MgO(100) substrates by molecular-beam epitaxy (MBE) using distilled ozone. Systematic measurements showed that the rubidium content was nearly independent of rubidium-beam-flux intensity in a wide beam-flux range. Therefore, it can be concluded that some degree of self-control of rubidium stoichiometry is actually possible in BRBO film growth by MBE. This study also revealed that the BRBO film properties had strong dependences on rubidium-beam-flux intensity even in the range for self-control of rubudium stoichiometry. Our study also clarified that rubidium-beam flux affects the barium content in the BRBO film.

  1. The directional dependence of apertures, limits and sensitivity of the lunar Cherenkov technique to a UHE neutrino flux

    NASA Astrophysics Data System (ADS)

    James, C. W.; Protheroe, R. J.

    2009-06-01

    We use computer simulations to obtain the directional-dependence of the lunar Cherenkov technique for ultra-high energy (UHE) neutrino detection. We calculate the instantaneous effective area of past lunar Cherenkov experiments at Parkes, Goldstone (Goldstone Lunar Ultra-high energy neutrino Experiment, GLUE), and Kalyazin, as a function of neutrino arrival direction, finding that the potential sensitivity to a point source of UHE neutrinos for these experiments was as much as thirty times that to an isotropic flux, depending on the beam-pointing position and incident neutrino energy. Convolving our results with the known lunar positions during the Parkes and Goldstone experiments allows us to calculate an exposure map, and hence the directional-dependence of the combined limit imposed by these experiments. In the 10 21-10 23 eV range, we find parts of the sky where the GLUE limit likely still dominates, and areas where none of the limits from either Parkes, GLUE, or experiments such as the Antarctic Impulsive Transient Antenna (ANITA) balloon experiment or FORTE (Fast On-orbit Recording of Transient Events) satellite experiment are likely to be significant. Hence a large anisotropic flux of UHE neutrinos from these regions is not yet excluded. We also determine the directional dependence of the aperture of future planned experiments with the Australia Telescope Compact Array (ATCA), Australian SKA Pathfinder (ASKAP) and the Square Kilometre Array (SKA) to a UHE neutrino flux, and calculate the potential annual exposure to astronomical objects as a function of angular distance from the lunar trajectory through celestial coordinates. We find that the potential exposure of all experiments at 10 20 eV and below, integrated over a calendar year, is flat out to ˜25° from the lunar trajectory and then drops off rapidly. The region of greater sensitivity includes much of the Supergalactic Plane, including M87 and Cen A, as well as the Galactic Centre. At higher energies

  2. Frequency dependence in seismoacoustic imaging of shallow free gas due to gas bubble resonance

    NASA Astrophysics Data System (ADS)

    Tóth, Zsuzsanna; Spiess, Volkhard; Keil, Hanno

    2015-12-01

    Shallow free gas is investigated in seismoacoustic data in 10 frequency bands covering a frequency range between 0.2 and 43 kHz. At the edge of a gassy patch in the Bornholm Basin (Baltic Sea), compressional wave attenuation caused by free gas is estimated from reflection amplitudes beneath the gassy sediment layer. Imaging of shallow free gas is considerably influenced by gas bubble resonance, because in the resonance frequency range attenuation is significantly increased. At the resonance frequency of the largest bubbles between 3 and 5 kHz, high scattering causes complete acoustic blanking beneath the top of the gassy sediment layer. In the wider resonance frequency range between 3 and 15 kHz, the effect of smaller bubbles becomes dominant and the attenuation slightly decreases. This allows acoustic waves to be transmitted and reflections can be observed beneath the gassy sediment layer for higher frequencies. Above resonance beginning at ˜19 kHz, attenuation is low and the presence of free gas can be inferred from the decreased reflection amplitudes beneath the gassy layer. Below the resonance frequency range (<1 kHz), attenuation is generally very low and not dependent on frequency. Using the geoacoustic model of Anderson and Hampton, the observed frequency boundaries suggest gas bubble sizes between 1 and 4-6 mm, and gas volume fractions up to 0.02% in a ˜2 m thick sediment layer, whose upper boundary is the gas front. With the multifrequency acoustic approach and the Anderson and Hampton model, quantification of free gas in shallow marine environments is possible if the measurement frequency range allows the identification of the resonance frequency peak. The method presented is limited to places with only moderate attenuation, where the amplitudes of a reflection can be analyzed beneath the gassy sediment layer.

  3. Theoretical basal Ca II and Mg II fluxes for late-type stars: results from acoustic wave spectra with time-dependent ionization and multilevel radiation treatments

    NASA Astrophysics Data System (ADS)

    Fawzy, Diaa E.

    2015-08-01

    Computations of chromospheric models and the resulting spectral line emission fluxes are presented for late-type stars exhibiting very low level of chromospheric activity, referred to as a basal flux stars or low activity stars. The computations are self-consistent, and consider the entire acoustic wave energy spectra generated in the stellar convection zones. We consider multilevel atomic models, take into account departures from local thermodynamic equilibrium and also consider the time-dependent ionization processes of hydrogen. We employ the new finding of the mixing-length parameter α = 1.8. The Ca II H+K and Mg II h+k line fluxes are computed assuming pseudo-partial redistribution. The results show the importance of time-dependent ionization in modelling the middle and high chromospheres. Models without considering time-dependent ionization overestimate the emitted Ca II fluxes by factors between 1.1 and 5.6 for F8V and M0V stars, respectively, while factors between 1.8 for G0V and 17.4 for M0V stars have been obtained for the Mg II fluxes. The theoretically computed basal fluxes in Ca II and Mg II, respectively, follow simple linear formulae depending on the effective temperature log Teff. The obtained results for Ca II fluxes show reasonable agreement with observations.

  4. Time-dependent excitation and ionization modelling of absorption-line variability due to GRB 080310

    NASA Astrophysics Data System (ADS)

    Vreeswijk, P. M.; Ledoux, C.; Raassen, A. J. J.; Smette, A.; De Cia, A.; Woźniak, P. R.; Fox, A. J.; Vestrand, W. T.; Jakobsson, P.

    2013-01-01

    We model the time-variable absorption of Fe II, Fe III, Si II, C II and Cr II detected in Ultraviolet and Visual Echelle Spectrograph (UVES) spectra of gamma-ray burst (GRB) 080310, with the afterglow radiation exciting and ionizing the interstellar medium in the host galaxy at a redshift of z = 2.42743. To estimate the rest-frame afterglow brightness as a function of time, we use a combination of the optical VRI photometry obtained by the RAPTOR-T telescope array, which is presented in this paper, and Swift's X-Ray Telescope (XRT) observations. Excitation alone, which has been successfully applied for a handful of other GRBs, fails to describe the observed column density evolution in the case of GRB 080310. Inclusion of ionization is required to explain the column density decrease of all observed Fe II levels (including the ground state 6D9/2) and increase of the Fe III 7S3 level. The large population of ions in this latter level (up to 10% of all Fe III) can only be explained through ionization of Fe II, as a large fraction of the ionized Fe II ions (we calculate 31% using the Flexible Atomic and Cowan codes) initially populate the 7S3 level of Fe III rather than the ground state. This channel for producing a significant Fe III 7S3 level population may be relevant for other objects in which absorption lines from this level, the UV34 triplet, are observed, such as broad absorption line (BAL) quasars and η Carinae. This provides conclusive evidence for time-variable ionization in the circumburst medium, which to date has not been convincingly detected. However, the best-fit distance of the neutral absorbing cloud to the GRB is 200-400 pc, i.e. similar to GRB-absorber distance estimates for GRBs without any evidence for ionization. We find that the presence of time-varying ionization in GRB 080310 is likely due to a combination of the super-solar iron abundance ([Fe/H] = +0.2) and the low H I column density (log N(H i) = 18.7) in the host of GRB 080310. Finally

  5. Linear MHD Wave Propagation in Time-Dependent Flux Tube. I. Zero Plasma-β

    NASA Astrophysics Data System (ADS)

    Williamson, A.; Erdélyi, R.

    2014-03-01

    MHD waves and oscillations in sharply structured magnetic plasmas have been studied for static and steady systems in the thin tube approximation over many years. This work will generalize these studies by introducing a slowly varying background density in time, in order to determine the changes to the wave parameters introduced by this temporally varying equilibrium, i.e. to investigate the amplitude, frequency, and wavenumber for the kink and higher order propagating fast magnetohydrodynamic wave in the leading order approximation to the WKB approach in a zero- β plasma representing the upper solar atmosphere. To progress, the thin tube and over-dense loop approximations are used, restricting the results found here to the duration of a number of multiples of the characteristic density change timescale. Using such approximations it is shown that the amplitude of the kink wave is enhanced in a manner proportional to the square of the Alfvén speed, . The frequency of the wave solution tends to the driving frequency of the system as time progresses; however, the wavenumber approaches zero after a large multiple of the characteristic density change timescale, indicating an ever increasing wavelength. For the higher order fluting modes the changes in amplitude are dependent upon the wave mode; for the m=2 mode the wave is amplified to a constant level; however, for all m≥3 the fast MHD wave is damped within a relatively small multiple of the characteristic density change timescale. Understanding MHD wave behavior in time-dependent plasmas is an important step towards a more complete model of the solar atmosphere and has a key role to play in solar magneto-seismological applications.

  6. Integration of transcription and flux data reveals molecular paths associated with differences in oxygen-dependent phenotypes of Saccharomyces cerevisiae

    PubMed Central

    2014-01-01

    Background Saccharomyces cerevisiae is able to adapt to a wide range of external oxygen conditions. Previously, oxygen-dependent phenotypes have been studied individually at the transcriptional, metabolite, and flux level. However, the regulation of cell phenotype occurs across the different levels of cell function. Integrative analysis of data from multiple levels of cell function in the context of a network of several known biochemical interaction types could enable identification of active regulatory paths not limited to a single level of cell function. Results The graph theoretical method called Enriched Molecular Path detection (EMPath) was extended to enable integrative utilization of transcription and flux data. The utility of the method was demonstrated by detecting paths associated with phenotype differences of S. cerevisiae under three different conditions of oxygen provision: 20.9%, 2.8% and 0.5%. The detection of molecular paths was performed in an integrated genome-scale metabolic and protein-protein interaction network. Conclusions The molecular paths associated with the phenotype differences of S. cerevisiae under conditions of different oxygen provisions revealed paths of molecular interactions that could potentially mediate information transfer between processes that respond to the particular oxygen availabilities. PMID:24528924

  7. The Hardening Hypothesis: Is the Ability to Quit Decreasing Due to Increasing Nicotine Dependence? A Review and Commentary

    PubMed Central

    Hughes, John R.

    2011-01-01

    The “hardening hypothesis” states tobacco control activities have mostly influenced those smokers who found it easier to quit and, thus, remaining smokers are those who are less likely to stop smoking. This paper first describes a conceptual model for hardening. Then the paper describes important methodological distinctions (quit attempts vs. ability to remain abstinent as indicators, measures of hardening per se vs. measures of causes of hardening, and dependence measures that do vs. do not include cigarettes per day (cigs/day).) After this commentary, the paper reviews data from prior reviews and new searches for studies on one type of hardening: the decreasing ability to quit due to increasing nicotine dependence. Overall, all four studies of the general population of smokers found no evidence of decreased ability to quit; however, both secondary analyses of treatment-seeking smokers found quit rates were decreasing over time. Cigs/day and time-to-first cigarette measures of dependence did not increase over time; however, two studies found that DSM-defined dependence appeared to be increasing over time. Although these data suggest hardening may be occurring in treatment seekers but perhaps not in the general population of smokers, this conclusion may be premature given the small number of data sets and indirect measures of quit success and dependence in the data sets. Future studies should include questions about quit attempts, ability to abstain, treatment use, and multi-item dependence measures. PMID:21411244

  8. Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain

    PubMed Central

    Li, Longfei; Braun, R. J.; Maki, K. L.; Henshaw, W. D.; King-Smith, P. E.

    2014-01-01

    We study tear film dynamics with evaporation on a wettable eye-shaped ocular surface using a lubrication model. The mathematical model has a time-dependent flux boundary condition that models the cycles of tear fluid supply and drainage; it mimics blinks on a stationary eye-shaped domain. We generate computational grids and solve the nonlinear governing equations using the OVERTURE computational framework. In vivo experimental results using fluorescent imaging are used to visualize the influx and redistribution of tears for an open eye. Results from the numerical simulations are compared with the experiment. The model captures the flow around the meniscus and other dynamic features of human tear film observed in vivo. PMID:24926191

  9. Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain

    NASA Astrophysics Data System (ADS)

    Li, Longfei; Braun, R. J.; Maki, K. L.; Henshaw, W. D.; King-Smith, P. E.

    2014-05-01

    We study tear film dynamics with evaporation on a wettable eye-shaped ocular surface using a lubrication model. The mathematical model has a time-dependent flux boundary condition that models the cycles of tear fluid supply and drainage; it mimics blinks on a stationary eye-shaped domain. We generate computational grids and solve the nonlinear governing equations using the OVERTURE computational framework. In vivo experimental results using fluorescent imaging are used to visualize the influx and redistribution of tears for an open eye. Results from the numerical simulations are compared with the experiment. The model captures the flow around the meniscus and other dynamic features of human tear film observed in vivo.

  10. A new approach to model oxygen dependent benthic phosphate fluxes in the Baltic Sea

    NASA Astrophysics Data System (ADS)

    Almroth-Rosell, Elin; Eilola, Kari; Kuznetsov, Ivan; Hall, Per O. J.; Meier, H. E. Markus

    2015-04-01

    The new approach to model the oxygen dependent phosphate release by implementing formulations of the oxygen penetration depths (OPD) and mineral bound inorganic phosphorus pools to the Swedish Coastal and Ocean Biogeochemical model (SCOBI) is described. The phosphorus dynamics and the oxygen concentrations in the Baltic proper sediment are studied during the period 1980-2008 using SCOBI coupled to the 3D-Rossby Centre Ocean model. Model data are compared to observations from monitoring stations and experiments. The impact from oxygen consumption on the determination of the OPD is found to be largest in the coastal zones where also the largest OPD are found. In the deep water the low oxygen concentrations mainly determine the OPD. Highest modelled release rate of phosphate from the sediment is about 59 × 103 t P year- 1 and is found on anoxic sediment at depths between 60-150 m, corresponding to 17% of the Baltic proper total area. The deposition of organic and inorganic phosphorus on sediments with oxic bottom water is larger than the release of phosphorus, about 43 × 103 t P year- 1. For anoxic bottoms the release of total phosphorus during the investigated period is larger than the deposition, about 19 × 103 t P year- 1. In total the net Baltic proper sediment sink is about 23.7 × 103 t P year- 1. The estimated phosphorus sink efficiency of the entire Baltic Sea is on average about 83% during the period.

  11. Activity-dependent branching ratios in stocks, solar x-ray flux, and the Bak-Tang-Wiesenfeld sandpile model

    NASA Astrophysics Data System (ADS)

    Martin, Elliot; Shreim, Amer; Paczuski, Maya

    2010-01-01

    We define an activity-dependent branching ratio that allows comparison of different time series Xt . The branching ratio bx is defined as bx=E[ξx/x] . The random variable ξx is the value of the next signal given that the previous one is equal to x , so ξx={Xt+1∣Xt=x} . If bx>1 , the process is on average supercritical when the signal is equal to x , while if bx<1 , it is subcritical. For stock prices we find bx=1 within statistical uncertainty, for all x , consistent with an “efficient market hypothesis.” For stock volumes, solar x-ray flux intensities, and the Bak-Tang-Wiesenfeld (BTW) sandpile model, bx is supercritical for small values of activity and subcritical for the largest ones, indicating a tendency to return to a typical value. For stock volumes this tendency has an approximate power-law behavior. For solar x-ray flux and the BTW model, there is a broad regime of activity where bx≃1 , which we interpret as an indicator of critical behavior. This is true despite different underlying probability distributions for Xt and for ξx . For the BTW model the distribution of ξx is Gaussian, for x sufficiently larger than 1, and its variance grows linearly with x . Hence, the activity in the BTW model obeys a central limit theorem when sampling over past histories. The broad region of activity where bx is close to one disappears once bulk dissipation is introduced in the BTW model—supporting our hypothesis that it is an indicator of criticality.

  12. Activity-dependent branching ratios in stocks, solar x-ray flux, and the Bak-Tang-Wiesenfeld sandpile model.

    PubMed

    Martin, Elliot; Shreim, Amer; Paczuski, Maya

    2010-01-01

    We define an activity-dependent branching ratio that allows comparison of different time series X(t). The branching ratio b(x) is defined as b(x)=E[xi(x)/x]. The random variable xi(x) is the value of the next signal given that the previous one is equal to x, so xi(x)=[X(t+1) | X(t)=x]. If b(x)>1, the process is on average supercritical when the signal is equal to x, while if b(x)<1, it is subcritical. For stock prices we find b(x)=1 within statistical uncertainty, for all x, consistent with an "efficient market hypothesis." For stock volumes, solar x-ray flux intensities, and the Bak-Tang-Wiesenfeld (BTW) sandpile model, b(x) is supercritical for small values of activity and subcritical for the largest ones, indicating a tendency to return to a typical value. For stock volumes this tendency has an approximate power-law behavior. For solar x-ray flux and the BTW model, there is a broad regime of activity where b(x) approximately equal 1, which we interpret as an indicator of critical behavior. This is true despite different underlying probability distributions for X(t) and for xi(x). For the BTW model the distribution of xi(x) is Gaussian, for x sufficiently larger than 1, and its variance grows linearly with x. Hence, the activity in the BTW model obeys a central limit theorem when sampling over past histories. The broad region of activity where b(x) is close to one disappears once bulk dissipation is introduced in the BTW model-supporting our hypothesis that it is an indicator of criticality. PMID:20365434

  13. The uncertainty of UTCI due to uncertainties in the determination of radiation fluxes derived from numerical weather prediction and regional climate model simulations

    NASA Astrophysics Data System (ADS)

    Schreier, Stefan F.; Suomi, Irene; Bröde, Peter; Formayer, Herbert; Rieder, Harald E.; Nadeem, Imram; Jendritzky, Gerd; Batchvarova, Ekaterina; Weihs, Philipp

    2013-03-01

    In this study we examine the determination accuracy of both the mean radiant temperature (Tmrt) and the Universal Thermal Climate Index (UTCI) within the scope of numerical weather prediction (NWP), and global (GCM) and regional (RCM) climate model simulations. First, Tmrt is determined and the so-called UTCI-Fiala model is then used for the calculation of UTCI. Taking into account the uncertainties of NWP model (among others the HIgh Resolution Limited Area Model HIRLAM) output (temperature, downwelling short-wave and long-wave radiation) stated in the literature, we simulate and discuss the uncertainties of Tmrt and UTCI at three stations in different climatic regions of Europe. The results show that highest negative (positive) differences to reference cases (under assumed clear-sky conditions) of up to -21°C (9°C) for Tmrt and up to -6°C (3.5°C) for UTCI occur in summer (winter) due to cloudiness. In a second step, the uncertainties of RCM simulations are analyzed: three RCMs, namely ALADIN (Aire Limitée Adaptation dynamique Développement InterNational), RegCM (REGional Climate Model) and REMO (REgional MOdel) are nested into GCMs and used for the prediction of temperature and radiation fluxes in order to estimate Tmrt and UTCI. The inter-comparison of RCM output for the three selected locations shows that biases between 0.0 and ±17.7°C (between 0.0 and ±13.3°C) for Tmrt (UTCI), and RMSE between ±0.5 and ±17.8°C (between ±0.8 and ±13.4°C) for Tmrt (UTCI) may be expected. In general the study shows that uncertainties of UTCI, due to uncertainties arising from calculations of radiation fluxes (based on NWP models) required for the prediction of Tmrt, are well below ±2°C for clear-sky cases. However, significant higher uncertainties in UTCI of up to ±6°C are found, especially when prediction of cloudiness is wrong.

  14. Preliminary Assessment of the Impact on Reactor Vessel dpa Rates Due to Installation of a Proposed Low Enriched Uranium (LEU) Core in the High Flux Isotope Reactor (HFIR)

    SciTech Connect

    Daily, Charles R.

    2015-10-01

    An assessment of the impact on the High Flux Isotope Reactor (HFIR) reactor vessel (RV) displacements-per-atom (dpa) rates due to operations with the proposed low enriched uranium (LEU) core described by Ilas and Primm has been performed and is presented herein. The analyses documented herein support the conclusion that conversion of HFIR to low-enriched uranium (LEU) core operations using the LEU core design of Ilas and Primm will have no negative impact on HFIR RV dpa rates. Since its inception, HFIR has been operated with highly enriched uranium (HEU) cores. As part of an effort sponsored by the National Nuclear Security Administration (NNSA), conversion to LEU cores is being considered for future HFIR operations. The HFIR LEU configurations analyzed are consistent with the LEU core models used by Ilas and Primm and the HEU balance-of-plant models used by Risner and Blakeman in the latest analyses performed to support the HFIR materials surveillance program. The Risner and Blakeman analyses, as well as the studies documented herein, are the first to apply the hybrid transport methods available in the Automated Variance reduction Generator (ADVANTG) code to HFIR RV dpa rate calculations. These calculations have been performed on the Oak Ridge National Laboratory (ORNL) Institutional Cluster (OIC) with version 1.60 of the Monte Carlo N-Particle 5 (MCNP5) computer code.

  15. Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation

    PubMed Central

    Mamidi, Ranganath; Gresham, Kenneth S.; Stelzer, Julian E.

    2014-01-01

    Enhanced cardiac contractile function with increased sarcomere length (SL) is, in part, mediated by a decrease in the radial distance between myosin heads and actin. The radial disposition of myosin heads relative to actin is modulated by cardiac myosin binding protein-C (cMyBP-C), suggesting that cMyBP-C contributes to the length-dependent activation (LDA) in the myocardium. However, the precise roles of cMyBP-C in modulating cardiac LDA are unclear. To determine the impact of cMyBP-C on LDA, we measured isometric force, myofilament Ca2+-sensitivity (pCa50) and length-dependent changes in kinetic parameters of cross-bridge (XB) relaxation (krel), and recruitment (kdf) due to rapid stretch, as well as the rate of force redevelopment (ktr) in response to a large slack-restretch maneuver in skinned ventricular multicellular preparations isolated from the hearts of wild-type (WT) and cMyBP-C knockout (KO) mice, at SL's 1.9 μm or 2.1 μm. Our results show that maximal force was not significantly different between KO and WT preparations but length-dependent increase in pCa50 was attenuated in the KO preparations. pCa50 was not significantly different between WT and KO preparations at long SL (5.82 ± 0.02 in WT vs. 5.87 ± 0.02 in KO), whereas pCa50 was significantly different between WT and KO preparations at short SL (5.71 ± 0.02 in WT vs. 5.80 ± 0.01 in KO; p < 0.05). The ktr, measured at half-maximal Ca2+-activation, was significantly accelerated at short SL in WT preparations (8.74 ± 0.56 s−1 at 1.9 μm vs. 5.71 ± 0.40 s−1 at 2.1 μm, p < 0.05). Furthermore, krel and kdf were accelerated by 32% and 50%, respectively at short SL in WT preparations. In contrast, ktr was not altered by changes in SL in KO preparations (8.03 ± 0.54 s−1 at 1.9 μm vs. 8.90 ± 0.37 s−1 at 2.1 μm). Similarly, KO preparations did not exhibit length-dependent changes in krel and kdf. Collectively, our data implicate cMyBP-C as an important regulator of LDA via its impact on

  16. Parallel machine scheduling problem with ready times, due times and sequence-dependent setup times using meta-heuristic algorithms

    NASA Astrophysics Data System (ADS)

    Joo, Cheol Min; Kim, Byung Soo

    2012-09-01

    This article considers a parallel machine scheduling problem with ready times, due times and sequence-dependent setup times. The objective of this problem is to determine the allocation policy of jobs and the scheduling policy of machines to minimize the weighted sum of setup times, delay times and tardy times. A mathematical model for optimal solution is derived. An in-depth analysis of the model shows that it is very complicated and difficult to obtain optimal solutions as the problem size becomes large. Therefore, two meta-heuristics, genetic algorithm (GA) and a new population-based evolutionary meta-heuristic called self-evolution algorithm (SEA), are proposed. The performances of the meta-heuristic algorithms are evaluated through comparison with optimal solutions using several randomly generated examples.

  17. The Cystic Fibrosis Transmembrane Conductance Regulator and Chloride-Dependent Ion Fluxes of Ovine Vocal Fold Epithelium

    ERIC Educational Resources Information Center

    Leydon, Ciara; Fisher, Kimberly V.; Lodewyck-Falciglia, Danielle

    2009-01-01

    Purpose: Ion-driven transepithelial water fluxes participate in maintaining superficial vocal fold hydration, which is necessary for normal voice production. The authors hypothesized that Cl[superscript -] channels are present in vocal fold epithelial cells and that transepithelial Cl[superscript -] fluxes can be manipulated pharmacologically.…

  18. Theoretical limits on the threshold for the response of long cells to weak extremely low frequency electric fields due to ionic and molecular flux rectification.

    PubMed Central

    Weaver, J C; Vaughan, T E; Adair, R K; Astumian, R D

    1998-01-01

    Understanding exposure thresholds for the response of biological systems to extremely low frequency (ELF) electric and magnetic fields is a fundamental problem of long-standing interest. We consider a two-state model for voltage-gated channels in the membrane of an isolated elongated cell (Lcell = 1 mm; rcell = 25 micron) and use a previously described process of ionic and molecular flux rectification to set lower bounds for a threshold exposure. A key assumption is that it is the ability of weak physical fields to alter biochemistry that is limiting, not the ability of a small number of molecules to alter biological systems. Moreover, molecular shot noise, not thermal voltage noise, is the basis of threshold estimates. Models with and without stochastic resonance are used, with a long exposure time, texp = 10(4) s. We also determined the dependence of the threshold on the basal transport rate. By considering both spherical and elongated cells, we find that the lowest bound for the threshold is Emin approximately 9 x 10(-3) V m-1 (9 x 10(-5) V cm-1). Using a conservative value for the loop radius rloop = 0.3 m for induced current, the corresponding lower bound in the human body for a magnetic field exposure is Bmin approximately 6 x 10(-4) T (6 G). Unless large, organized, and electrically amplifying multicellular systems such as the ampullae of Lorenzini of elasmobranch fish are involved, these results strongly suggest that the biophysical mechanism of voltage-gated macromolecules in the membranes of cells can be ruled out as a basis of possible effects of weak ELF electric and magnetic fields in humans. PMID:9788920

  19. Hybrid-like 2/1 flux-pumping and magnetic island evolution due to edge localized mode-neoclassical tearing mode coupling in DIII-D

    NASA Astrophysics Data System (ADS)

    King, J. D.; La Haye, R. J.; Petty, C. C.; Osborne, T. H.; Lasnier, C. J.; Groebner, R. J.; Volpe, F. A.; Lanctot, M. J.; Makowski, M. A.; Holcomb, C. T.; Solomon, W. M.; Allen, S. L.; Luce, T. C.; Austin, M. E.; Meyer, W. H.; Morse, E. C.

    2012-02-01

    Direct analysis of internal magnetic field pitch angles measured using the motional Stark effect diagnostic shows m /n=2/1 neoclassical tearing modes exhibit stronger poloidal magnetic flux-pumping than typical hybrids containing m /n=3/2 modes. This flux-pumping causes the avoidance of sawteeth, and is present during partial electron cyclotron current drive suppression of the tearing mode. This finding could lead to hybrid discharges with higher normalized fusion performance at lower q95. The degree of edge localized mode-neoclassical tearing mode (ELM-NTM) coupling and the strength of flux-pumping increase with beta and the proximity of the modes to the ELMing pedestal. Flux-pumping appears independent of magnetic island width. Individual ELM-NTM coupling events show a rapid timescale drop in the island width followed by a resistive recovery that is successfully modeled using the modified Rutherford equation. The fast transient drop in island width increases with ELM size.

  20. Critical film thickness dependence on As flux in In{sub 0.27}Ga{sub 0.73}As/GaAs(001) films

    SciTech Connect

    Riposan, A.; Mirecki Millunchick, J.; Pearson, Chris

    2007-02-26

    The transition between planar and nonplanar growth is examined for compressively strained In{sub 0.27}Ga{sub 0.73}As/GaAs(001) films using reflection high energy electron diffraction, atomic force microscopy, and scanning tunneling microscopy (STM). For a narrow range of temperature and composition, the critical thickness (t{sub SK}) is strongly dependent on As flux. For high values of As flux, t{sub SK} increases by more than a factor of 2. The morphology of three-dimensional islands formed during the initial stages of nonplanar growth is also characterized by high resolution STM.

  1. Mode- and Direction-Dependent Mechanical Energy Dissipation in Single-Crystal Resonators due to Anharmonic Phonon-Phonon Scattering

    NASA Astrophysics Data System (ADS)

    Iyer, Srikanth S.; Candler, Robert N.

    2016-03-01

    In this work, we determine the intrinsic mechanical energy dissipation limit for single-crystal resonators due to anharmonic phonon-phonon scattering in the Akhiezer (Ω τ ≪1 ) regime. The energy loss is derived using perturbation theory and the linearized Boltzmann transport equation for phonons, and includes the direction- and polarization-dependent mode-Grüneisen parameters in order to capture the strain-induced anharmonicity among phonon branches. This expression reveals the fundamental differences among the internal friction limits for different types of bulk-mode elastic waves. For cubic crystals, 2D-extensional modes have increased dissipation compared to width-extensional modes because the biaxial deformation opposes the natural Poisson contraction of the solid. Additionally, we show that shear-mode vibrations, which preserve volume, have significantly reduced energy loss because dissipative phonon-phonon scattering is restricted to pure-shear phonon branches, indicating that Lamé- or wineglass-mode resonators will have the highest upper limit on mechanical efficiency. Finally, we employ key simplifications to evaluate the quality factor limits for common mode shapes in single-crystal silicon devices, explicitly including the correct effective elastic storage moduli for different vibration modes and crystal orientations. Our expression satisfies the pressing need for a reliable analytical model that can predict the phonon-phonon dissipation limits for modern resonant microelectromechanical systems, where precise manufacturing techniques and accurate finite-element methods can be used to select particular vibrational mode shapes and crystal orientations.

  2. The Net Carbon Flux due to Deforestation and Forest Re-Growth in the Brazilian Amazon: Analysis using a Process-Based Model

    NASA Technical Reports Server (NTRS)

    Hirsch, A. I.; Little, W. S.; Houghton, R. A.; Scott, N. A.; White, J. D.

    2004-01-01

    We developed a process-based model of forest growth, carbon cycling, and land cover dynamics named CARLUC (for CARbon and Land Use Change) to estimate the size of terrestrial carbon pools in terra firme (non-flooded) forests across the Brazilian Legal Amazon and the net flux of carbon resulting from forest disturbance and forest recovery from disturbance. Our goal in building the model was to construct a relatively simple ecosystem model that would respond to soil and climatic heterogeneity that allows us to study of the impact of Amazonian deforestation, selective logging, and accidental fire on the global carbon cycle. This paper focuses on the net flux caused by deforestation and forest re-growth over the period from 1970-1998. We calculate that the net flux to the atmosphere during this period reached a maximum of approx. 0.35 PgC/yr (1PgC = 1 x 10(exp I5) gC) in 1990, with a cumulative release of approx. 7 PgC from 1970- 1998. The net flux is higher than predicted by an earlier study by a total of 1 PgC over the period 1989-1 998 mainly because CARLUC predicts relatively high mature forest carbon storage compared to the datasets used in the earlier study. Incorporating the dynamics of litter and soil carbon pools into the model increases the cumulative net flux by approx. 1 PgC from 1970-1998, while different assumptions about land cover dynamics only caused small changes. The uncertainty of the net flux, calculated with a Monte-Carlo approach, is roughly 35% of the mean value (1 SD).

  3. Hybrid-Like Discharges With 2/1 Flux-Pumping Due to ELM-NTM Coupling in DIII-D

    NASA Astrophysics Data System (ADS)

    King, J. D.; Lasnier, C. J.; Lanctot, M. J.; Makowski, M. A.; Holcomb, C. T.; Allen, S. L.; Meyer, W. H.; La Haye, R. J.; Petty, C. C.; Osborne, T. H.; Groebner, R. J.; Luce, T. C.; Volpe, F.; Austin, M. E.; Morse, E. C.

    2011-10-01

    Edge localized mode (ELM)-neoclassical tearing mode (NTM) coupling pumps poloidal flux from the core to the edge in hybrid discharges, contributing to flattening of the safety factor profile and avoidance of sawteeth. Direct motional Stark effect diagnostic analysis of internal magnetic field pitch angles show 2/1 NTMs exhibit stronger magnetic flux-pumping than typical hybrids, albeit at lower beta. This 2/1 flux-pumping is present during partial electron cyclotron current drive NTM suppression. This finding may lead to an alternative discharge with normalized fusion performance exceeding that required for Qfus = 10 operation in ITER. The strength of flux-pumping increases with beta and proximity of the NTM to the ELMing pedestal. Individual ELM-NTM coupling events are successfully modeled using the modified Rutherford equation (MRE). Work supported by US DOE under DE-AC52-07NA27344, DE-FC02-04ER54698, DE-FG03-97ER54415, and DE-FG03-89ER51116.

  4. Compartmental flux and in situ methods underestimate total feed nitrogen as judged by the omasal sampling method due to ignoring soluble feed nitrogen flow.

    PubMed

    Huhtanen, Pekka; Bayat, Alireza; Krizsan, Sophie J; Vanhatalo, Aila

    2014-02-01

    The objective of the present study was to estimate ruminal feed N outflow in lactating cows using the omasal sampling, compartmental flux or in situ method. A total of five ruminally fistulated Finnish Ayrshire dairy cows were used in a 5 × 5 Latin square study with 21 d periods. Experimental silages of grass or red clover harvested at two stages of maturity in addition to a supplement of 9·0 kg concentrate/d were fed to the cows. In vivo omasal N flow was determined using the omasal sampling technique. Ruminal in situ N flow was calculated from N intake and degradability (38 μm nylon bags). The samples of ruminal contents and faeces were divided into seven particle-size fractions by wet sieving; the concentrations of indigestible neutral-detergent fibre and N were used to calculate N flow in the compartmental flux method. In vivo omasal N flow was greater for the red clover silage diets than for the grass silage diets. The N flow calculated using the compartmental flux technique and that calculated using the in situ technique were highly correlated, but both were less than and poorly correlated with the in vivo N flow. In both in situ and compartmental flux techniques, forage maturity increased the particle-associated N flow, with the increase being significantly greater for the red clover diets than for the grass silage diets. In conclusion, the compartmental flux and in situ methods described the N flow associated with the particle fractions rather than the total ruminal outflow of feed N. PMID:23962678

  5. Dynamic two-axis model of a linear synchronous reluctance motor based on current and position-dependent characteristics of flux linkages

    NASA Astrophysics Data System (ADS)

    Štumberger, Gorazd; Štumberger, Bojan; Dolinar, Drago

    2006-09-01

    This paper analyses the impact of armature slotting and magnetically nonlinear and anisotropic iron core on the trajectories of a kinematically controlled linear synchronous reluctance motor (LSRM). A new magnetically nonlinear dynamic two-axis LSRM model is introduced in order to perform the analysis. The magnetic nonlinearities and slotting effects are accounted for by the current and position-dependent characteristics of flux linkages.

  6. Orientation-dependent critical currents in Y sub 1 Ba sub 2 Cu sub 3 O sub 7-x epitaxial thin films: Evidence for intrinsic flux pinning

    SciTech Connect

    Christen, D.K.; Klabunde, C.E.; Feenstra, R.; Lowndes, D.H.; Norton, D.P.; Budai, J.D.; Kerchner, H.R.; Thompson, J.R.; Zhu, S. ); Marwick, A.D. )

    1990-01-01

    For YBCO epitaxial thin films the basal plane transport critical current density J{sub c}, flowing perpendicular to an applied magnetic field H, depends sensitively on the orientation of the crystal with respect to H. In particular, J{sub c} is sharply peaked and greatly enhanced when H is precisely parallel to the copper-oxygen planes. Experiments on a series of epitaxial monolithic and superconductor-insulator multilayer thin films provide clear evidence that the enhancement is a bulk, rather than surface or thin sample, phenomenon. Measurements of the orientation dependence are presented and compared with a model of intrinsic flux pinning'' by the layered crystal structure.

  7. Radial Transport Characteristics of Fast Ions Due to Energetic-Particle Modes inside the Last Closed-Flux Surface in the Compact Helical System

    SciTech Connect

    Nagaoka, Kenichi; Isobe, Mitsutaka; Toi, Kazuo; Shimizu, Akihiro; Fujisawa, Akihide; Ohshima, Shunsuke; Nakano, Haruhisa; Osakabe, Masaki; Todo, Yasushi; Akiyama, Tsuyoshi; Suzuki, Chihiro; Nishimura, Shin; Yoshimura, Yasuo; Matsuoka, Keisuke; Okamura, Shoichi; Nagashima, Yoshihiko

    2008-02-15

    The internal behavior of fast ions interacting with magnetohydrodynamic bursts excited by energetic ions has been experimentally investigated in the compact helical system. The resonant convective oscillation of fast ions was identified inside the last closed-flux surface during an energetic-particle mode (EPM) burst. The phase difference between the fast-ion oscillation and the EPM, indicating the coupling strength between them, remains a certain value during the EPM burst and drives an anomalous transport of fast ions.

  8. Spatial Dependence of Heat Flux Transients and Wetting Behavior During Immersion Quenching of Inconel 600 Probe in Brine and Polymer Media

    NASA Astrophysics Data System (ADS)

    Ramesh, G.; Narayan Prabhu, K.

    2014-08-01

    Cooling curve analysis of Inconel 600 probe during immersion quenching in brine and polymer quench media was carried out. Thermal histories at various axial and radial locations were recorded using a high-speed data acquisition system and were input to an inverse heat-conduction model for estimating the metal/quenchant heat flux transients. A high performance smart camera was used for online video imaging of the immersion quenching process. Solution to two-dimensional inverse heat-conduction problem clearly brings out the spatial dependence of boundary heat flux transients for a Inconel 600 probe with a simple cylindrical geometry. The estimated heat flux transients show large variation on axial as well as radial directions of quench probe surface for brine quenching. Polymer quenching showed less variation in metal/quenchant heat flux transients. Shorter durations of vapor film, higher rewetting temperatures, and faster movement of wetting front on quench probe surface were observed with brine quenching. Measurement of dynamic contact angle showed better spreading and good wettability for polymer medium as compared to brine quenchant. The solid-liquid interfacial tension between polymer medium and Inconel substrate was lower compared with that of solution. Rewetting and boiling processes were nonuniform and faster on quench probe surface during immersion quenching in brine solution. For the polymer quench medium, slow rewetting, uniform boiling and repeated wetting were observed.

  9. Relative Magnitude and Controls of in Situ N2 and N2O Fluxes due to Denitrification in Natural and Seminatural Terrestrial Ecosystems Using (15)N Tracers.

    PubMed

    Sgouridis, Fotis; Ullah, Sami

    2015-12-15

    Denitrification is the most uncertain component of the nitrogen (N) cycle, hampering our ability to assess its contribution to reactive N (Nr) removal. This uncertainty emanates from the difficulty in measuring in situ soil N2 production and from the high spatiotemporal variability of the process itself. In situ denitrification was measured monthly between April 2013 and October 2014 in natural (organic and forest) and seminatural ecosystems (semi-improved and improved grasslands) in two UK catchments. Using the (15)N-gas flux method with low additions of (15)NO3(-) tracer, a minimum detectable flux rate of 4 μg N m(-2) h(-1) and 0.2 ng N m(-2) h(-1) for N2 and N2O, respectively, was achieved. Denitrification rates were lower in organic and forest (8 and 10 kg N ha(-1) y(-1), respectively) than in semi-improved and improved grassland soils (13 and 25 kg N ha(-1) y(-1), respectively). The ratio of N2O/N2 + N2O was low and ranged from <1% to 7% across the sites. Variation in denitrification was driven by differences in soil respiration, nitrate, C:N ratio, bulk density, moisture, and pH across the sites. Overall, the contribution of denitrification to Nr removal in natural ecosystems was ~50% of the annual atmospheric Nr deposition, making these ecosystems vulnerable to chronic N saturation. PMID:26509488

  10. Large increase in dissolved inorganic carbon flux from the Mississippi River to Gulf of Mexico due to climatic and anthropogenic changes over the 21st century

    NASA Astrophysics Data System (ADS)

    Ren, Wei; Tian, Hanqin; Tao, Bo; Yang, Jia; Pan, Shufen; Cai, Wei-Jun; Lohrenz, Steven E.; He, Ruoying; Hopkinson, Charles S.

    2015-04-01

    It is recognized that anthropogenic factors have had a major impact on carbon fluxes from land to the ocean during the past two centuries. However, little is known about how future changes in climate, atmospheric CO2, and land use may affect riverine carbon fluxes over the 21st century. Using a coupled hydrological-biogeochemical model, the Dynamic Land Ecosystem Model, this study examines potential changes in dissolved inorganic carbon (DIC) export from the Mississippi River basin to the Gulf of Mexico during 2010-2099 attributable to climate-related conditions (temperature and precipitation), atmospheric CO2, and land use change. Rates of annual DIC export are projected to increase by 65% under the high emission scenario (A2) and 35% under the low emission scenario (B1) between the 2000s and the 2090s. Climate-related changes along with rising atmospheric CO2 together would account for over 90% of the total increase in DIC export throughout the 21st century. The predicted increase in DIC export from the Mississippi River basin would alter chemistry of the coastal ocean unless appropriate climate mitigation actions are taken in the near future.

  11. Flow and Heat Transfer of Powell-Eyring Fluid due to an Exponential Stretching Sheet with Heat Flux and Variable Thermal Conductivity

    NASA Astrophysics Data System (ADS)

    Megahed, Ahmed M.

    2015-03-01

    An analysis was carried out to describe the problem of flow and heat transfer of Powell-Eyring fluid in boundary layers on an exponentially stretching continuous permeable surface with an exponential temperature distribution in the presence of heat flux and variable thermal conductivity. The governing partial differential equations describing the problem were transformed into a set of coupled non-linear ordinary differential equations and then solved with a numerical technique using appropriate boundary conditions for various physical parameters. The numerical solution for the governing non-linear boundary value problem is based on applying the shooting method over the entire range of physical parameters. The effects of various parameters like the thermal conductivity parameter, suction parameter, dimensionless Powell-Eyring parameters and the Prandtl number on the flow and temperature profiles as well as on the local skin-friction coefficient and the local Nusselt number are presented and discussed. In this work, special attention was given to investigate the effect of the thermal conductivity parameter on the velocity and temperature fields above the sheet in the presence of heat flux. The numerical results were also validated with results from a previously published work on various special cases of the problem, and good agreements were seen.

  12. Modified structural and frequency dependent impedance formalism of nanoscale BaTiO3 due to Tb inclusion

    NASA Astrophysics Data System (ADS)

    Borah, Manjit; Mohanta, Dambarudhar

    2016-05-01

    We report the effect of Tb-doping on the structural and high frequency impedance response of the nanoscale BaTiO3 (BT) systems. While exhibiting a mixed phase crystal structure, the nano-BT systems are found to evolve with edges, and facets. The interplanar spacing of crystal lattice fringes is ~0.25 nm. The Cole-Cole plots, in the impedance formalism, have demonstrated semicircles which are the characteristic feature of grain boundary resistance of several MΩ. A lowering of ac conductivity with doping was believed to be due to the manifestation of oxygen vacancies and vacancy ordering.

  13. Spin-Dependent Emission from Arrays of Planar Chiral Nanoantennas Due to Lattice and Localized Plasmon Resonances.

    PubMed

    Cotrufo, Michele; Osorio, Clara I; Koenderink, A Femius

    2016-03-22

    Chiral plasmonic nanoantennas manifest a strong asymmetric response to circularly polarized light. Particularly, the geometric handedness of a plasmonic structure can alter the circular polarization state of light emitted from nearby sources, leading to a spin-dependent emission direction. In past experiments, these effects have been attributed entirely to the localized plasmonic resonances of single antennas. In this work, we demonstrate that, when chiral nanoparticles are arranged in diffractive arrays, lattice resonances play a primary role in determining the spin-dependent emission of light. We fabricate 2D diffractive arrays of planar chiral metallic nanoparticles embedded in a light-emitting dye-doped slab. By measuring the polarized photoluminescence enhancement, we show that the geometric chirality of the array's unit cell induces a preferential circular polarization, and that both the localized surface plasmon resonance and the delocalized hybrid plasmonic-photonic mode contribute to this phenomenon. By further mapping the angle-resolved degree of circular polarization, we demonstrate that strong chiral dissymmetries are mainly localized at the narrow emission directions of the surface lattice resonances. We validate these results against a coupled dipole model calculation, which correctly reproduces the main features. Our findings demonstrate that, in diffractive arrays, lattice resonances play a primary role into the light spin-orbit effect, introducing a highly nontrivial behavior in the angular spectra. PMID:26854880

  14. Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice

    PubMed Central

    Kim, Yeon Sun; Kim, Hye-Ryun; Kim, Hyongbum; Yang, Seung Chel; Park, Mira; Yoon, Jung Ah; Lim, Hyunjung J.; Hong, Seok-Ho; DeMayo, Francesco J.; Lydon, John P.; Choi, Youngsok; Lee, Dong Ryul; Song, Haengseok

    2016-01-01

    DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm. Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgcr8d/d) and demonstrated that canonical microRNAs dependent on the DROSHA-DGCR8 complex are required for uterine development as well as female fertility in mice. Adult Dgcr8d/d females neither underwent regular reproductive cycles nor produced pups, whereas administration of exogenous gonadotropins induced normal ovulation in these mice. Interestingly, immune cells associated with acute inflammation aberrantly infiltrated into reproductive organs of pregnant Dgcr8d/d mice. Regarding uterine development, multiple uterine abnormalities were noticeable at 4 weeks of age when PR is significantly increased, and the severity of these deformities increased over time. Gland formation and myometrial layers were significantly reduced, and the stromal cell compartment did not expand and became atrophic during uterine development in these mice. These results were consistent with aberrantly reduced stromal cell proliferation and completely failed decidualization. Collectively, we suggest that DGCR8-dependent canonical microRNAs are essential for uterine development and physiological processes such as proper immune modulation, reproductive cycle, and steroid hormone responsiveness in mice. PMID:26833131

  15. Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

    PubMed Central

    2015-01-01

    The aim of this study was to determine the size-dependent penetration ability of gold nanoparticles and the potential application of ultrasmall gold nanoparticles for intranucleus delivery and therapy. We synthesized gold nanoparticles with diameters of 2, 6, 10, and 16 nm and compared their intracellular distribution in MCF-7 breast cancer cells. Nanoparticles smaller than 10 nm (2 and 6 nm) could enter the nucleus, whereas larger ones (10 and 16 nm) were found only in the cytoplasm. We then investigated the possibility of using ultrasmall 2 nm nanoparticles as carriers for nuclear delivery of a triplex-forming oligonucleotide (TFO) that binds to the c-myc promoter. Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. Our result demonstrated that the entry of gold nanoparticles into the cell nucleus is critically dependent on the size of the nanoparticles. We developed a strategy for regulating gene expression, by directly delivering TFOs into the nucleus using ultrasmall gold nanoparticles. More importantly, guidelines were provided to choose appropriate nanocarriers for different biomedical purposes. PMID:24824865

  16. Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry.

    PubMed

    Huo, Shuaidong; Jin, Shubin; Ma, Xiaowei; Xue, Xiangdong; Yang, Keni; Kumar, Anil; Wang, Paul C; Zhang, Jinchao; Hu, Zhongbo; Liang, Xing-Jie

    2014-06-24

    The aim of this study was to determine the size-dependent penetration ability of gold nanoparticles and the potential application of ultrasmall gold nanoparticles for intranucleus delivery and therapy. We synthesized gold nanoparticles with diameters of 2, 6, 10, and 16 nm and compared their intracellular distribution in MCF-7 breast cancer cells. Nanoparticles smaller than 10 nm (2 and 6 nm) could enter the nucleus, whereas larger ones (10 and 16 nm) were found only in the cytoplasm. We then investigated the possibility of using ultrasmall 2 nm nanoparticles as carriers for nuclear delivery of a triplex-forming oligonucleotide (TFO) that binds to the c-myc promoter. Compared to free TFO, the nanoparticle-conjugated TFO was more effective at reducing c-myc RNA and c-myc protein, which resulted in reduced cell viability. Our result demonstrated that the entry of gold nanoparticles into the cell nucleus is critically dependent on the size of the nanoparticles. We developed a strategy for regulating gene expression, by directly delivering TFOs into the nucleus using ultrasmall gold nanoparticles. More importantly, guidelines were provided to choose appropriate nanocarriers for different biomedical purposes. PMID:24824865

  17. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates

    PubMed Central

    Adams, Dany S.; Robinson, Kenneth R.; Fukumoto, Takahiro; Yuan, Shipeng; Albertson, R. Craig; Yelick, Pamela; Kuo, Lindsay; McSweeney, Megan; Levin, Michael

    2011-01-01

    Biased left-right asymmetry is a fascinating and medically important phenomenon. We provide molecular genetic and physiological characterization of a novel, conserved, early, biophysical event that is crucial for correct asymmetry: H+ flux. A pharmacological screen implicated the H+-pump H+-V-ATPase in Xenopus asymmetry, where it acts upstream of early asymmetric markers. Immunohistochemistry revealed an actin-dependent asymmetry of H+-V-ATPase subunits during the first three cleavages. H+-flux across plasma membranes is also asymmetric at the four- and eight-cell stages, and this asymmetry requires H+-V-ATPase activity. Abolishing the asymmetry in H+ flux, using a dominant-negative subunit of the H+-V-ATPase or an ectopic H+ pump, randomized embryonic situs without causing any other defects. To understand the mechanism of action of H+-V-ATPase, we isolated its two physiological functions, cytoplasmic pH and membrane voltage (Vmem) regulation. Varying either pH or Vmem, independently of direct manipulation of H+-V-ATPase, caused disruptions of normal asymmetry, suggesting roles for both functions. V-ATPase inhibition also abolished the normal early localization of serotonin, functionally linking these two early asymmetry pathways. The involvement of H+-V-ATPase in asymmetry is conserved to chick and zebrafish. Inhibition of the H+-V-ATPase induces heterotaxia in both species; in chick, H+-V-ATPase activity is upstream of Shh; in fish, it is upstream of Kupffer's vesicle and Spaw expression. Our data implicate H+-V-ATPase activity in patterning the LR axis of vertebrates and reveal mechanisms upstream and downstream of its activity. We propose a pH- and Vmem-dependent model of the early physiology of LR patterning. PMID:16554361

  18. ENERGY-DEPENDENT GAMMA-RAY BURST PULSE WIDTH DUE TO THE CURVATURE EFFECT AND INTRINSIC BAND SPECTRUM

    SciTech Connect

    Peng, Z. Y.; Ma, L.; Zhao, X. H.; Yin, Y.; Bao, Y. Y.

    2012-06-20

    Previous studies have found that the width of the gamma-ray burst (GRB) pulse is energy dependent and that it decreases as a power-law function with increasing photon energy. In this work we have investigated the relation between the energy dependence of the pulse and the so-called Band spectrum by using a sample including 51 well-separated fast rise and exponential decay long-duration GRB pulses observed by BATSE (Burst and Transient Source Experiment on the Compton Gamma Ray Observatory). We first decompose these pulses into rise and decay phases and find that the rise widths and the decay widths also behave as a power-law function with photon energy. Then we investigate statistically the relations between the three power-law indices of the rise, decay, and total width of the pulse (denoted as {delta}{sub r}, {delta}{sub d}, and {delta}{sub w}, respectively) and the three Band spectral parameters, high-energy index ({alpha}), low-energy index ({beta}), and peak energy (E{sub p} ). It is found that (1) {alpha} is strongly correlated with {delta}{sub w} and {delta}{sub d} but seems uncorrelated with {delta}{sub r}; (2) {beta} is weakly correlated with the three power-law indices, and (3) E{sub p} does not show evident correlations with the three power-law indices. We further investigate the origin of {delta}{sub d}-{alpha} and {delta}{sub w}-{alpha}. We show that the curvature effect and the intrinsic Band spectrum could naturally lead to the energy dependence of the GRB pulse width and also the {delta}{sub d}-{alpha} and {delta}{sub w}-{alpha} correlations. Our results hold so long as the shell emitting gamma rays has a curved surface and the intrinsic spectrum is a Band spectrum or broken power law. The strong {delta}{sub d}-{alpha} correlation and inapparent correlations between {delta}{sub r} and the three Band spectral parameters also suggest that the rise and decay phases of the GRB pulses have different origins.

  19. RF heating due to conductive wires during MRI depends on the phase distribution of the transmit field.

    PubMed

    Yeung, Christopher J; Susil, Robert C; Atalar, Ergin

    2002-12-01

    In many studies concerning wire heating during MR imaging, a "resonant wire length" that maximizes RF heating is determined. This may lead to the nonintuitive conclusion that adding more wire, so as to avoid this resonant length, will actually improve heating safety. Through a theoretical analysis using the method of moments, we show that this behavior depends on the phase distribution of the RF transmit field. If the RF transmit field has linear phase, with slope equal to the real part of the wavenumber in the tissue, long wires always heat more than short wires. In order to characterize the intrinsic safety of a device without reference to a specific body coil design, this maximum-tip heating phase distribution must be considered. Finally, adjusting the phase distribution of the electric field generated by an RF transmit coil may lead to an "implant-friendly" coil design. PMID:12465125

  20. Statistical model of the range-dependent error in radar-rainfall estimates due to the vertical profile of reflectivity

    NASA Astrophysics Data System (ADS)

    Krajewski, Witold F.; Vignal, Bertrand; Seo, Bong-Chul; Villarini, Gabriele

    2011-05-01

    SummaryThe authors developed an approach for deriving a statistical model of range-dependent error (RDE) in radar-rainfall estimates by parameterizing the structure of the non-uniform vertical profile of radar reflectivity (VPR). The proposed parameterization of the mean VPR and its expected variations are characterized by several climatological parameters that describe dominant atmospheric conditions related to vertical reflectivity variation. We have used four years of radar volume scan data from the Tulsa weather radar WSR-88D (Oklahoma) to illustrate this approach and have estimated the model parameters by minimizing the sum of the squared differences between the modeled and observed VPR influences that were computed using radar data. We evaluated the mean and standard deviation of the modeled RDE against rain gauge data from the Oklahoma Mesonet network. No rain gauge data were used in the model development. The authors used the three lowest antenna elevation angles to demonstrate the model performance for cold (November-April) and warm (May-October) seasons. The RDE derived from the parameterized models shows very good agreement with the observed differences between radar and rain gauge estimates of rainfall. For the third elevation angle and cold season, there are 82% and 42% improvements for the RDE and its standard deviation with respect to the no-VPR case. The results of this study indicate that VPR is a key factor in the characterization of the radar range-dependent bias, and the proposed models can be used to represent the radar RDE in the absence of rain gauge data.

  1. Impairment of Atg5-Dependent Autophagic Flux Promotes Paraquat- and MPP+-Induced Apoptosis But Not Rotenone or 6-Hydroxydopamine Toxicity

    PubMed Central

    Franco, Rodrigo

    2013-01-01

    Controversial reports on the role of autophagy as a survival or cell death mechanism in dopaminergic cell death induced by parkinsonian toxins exist. We investigated the alterations in autophagic flux and the role of autophagy protein 5 (Atg5)-dependent autophagy in dopaminergic cell death induced by parkinsonian toxins. Dopaminergic cell death induced by the mitochondrial complex I inhibitors 1-methyl-4-phenylpyridinium (MPP+) and rotenone, the pesticide paraquat, and the dopamine analog 6-hydroxydopamine (6-OHDA) was paralleled by increased autophagosome accumulation. However, when compared with basal autophagy levels using chloroquine, autophagosome accumulation was a result of impaired autophagic flux. Only 6-OHDA induced an increase in autophagosome formation. Overexpression of a dominant negative form of Atg5 increased paraquat- and MPP+-induced cell death. Stimulation of mammalian target of rapamycin (mTOR)-dependent signaling protected against cell death induced by paraquat, whereas MPP+-induced toxicity was enhanced by wortmannin, a phosphoinositide 3-kinase class III inhibitor, rapamycin, and trehalose, an mTOR-independent autophagy activator. Modulation of autophagy by either pharmacological or genetic approaches had no effect on rotenone or 6-OHDA toxicity. Cell death induced by parkinsonian neurotoxins was inhibited by the pan caspase inhibitor (Z-VAD), but only caspase-3 inhibition was able to decrease MPP+-induced cell death. Finally, inhibition of the lysosomal hydrolases, cathepsins, increased the toxicity by paraquat and MPP+, supporting a protective role of Atg5-dependent autophagy and lysosomes degradation pathways on dopaminegic cell death. These results demonstrate that in dopaminergic cells, Atg5-dependent autophagy acts as a protective mechanism during apoptotic cell death induced by paraquat and MPP+ but not during rotenone or 6-OHDA toxicity. PMID:23997112

  2. Diagnostic differentiation of mild cognitive impairment due to Alzheimer's disease using a hippocampus-dependent test of spatial memory.

    PubMed

    Moodley, Kuven; Minati, Ludovico; Contarino, Valeria; Prioni, Sara; Wood, Ruth; Cooper, Rebecca; D'Incerti, Ludovico; Tagliavini, Fabrizio; Chan, Dennis

    2015-08-01

    The hippocampus is one of the earliest brain regions affected in Alzheimer's disease (AD) and tests of hippocampal function have the potential to detect AD in its earliest stages. Given that the hippocampus is critically involved in allocentric spatial memory, this study applied a short test of spatial memory, the 4 Mountains Test (4MT), to determine whether test performance can differentiate mild cognitive impairment (MCI) patients with and without CSF biomarker evidence of underlying AD and whether the test can distinguish patients with MCI and mild AD dementia when applied in different cultural settings. Healthy controls (HC), patients with MCI, and mild AD dementia were recruited from study sites in UK and Italy. Study numbers were: HC (UK 20, Italy 10), MCI (UK 21, Italy 14), and AD (UK 11, Italy 9). Nineteen UK MCI patients were grouped into CSF biomarker-positive (MCI+, n = 10) and biomarker-negative (MCI-, n = 9) subgroups. Behavioral data were correlated with hippocampal volume and cortical thickness of the precuneus and posterior cingulate gyrus. Spatial memory was impaired in both UK and Italy MCI and AD patients. Test performance additionally differentiated between MCI+ and MCI- subgroups (P = 0.001). A 4MT score of ≤8/15 was associated with 100% sensitivity and 90% specificity for detection of early AD (MCI+ and mild AD dementia) in the UK population, and with 100% sensitivity and 50% specificity for detection of MCI and AD in the Italy sample. 4MT performance correlated with hippocampal volume in the UK population and cortical thickness of the precuneus in both study populations. In conclusion, performance on a hippocampus-sensitive test of spatial memory differentiates MCI due to AD with high diagnostic sensitivity and specificity. The observation that similar diagnostic sensitivity was obtained in two separate study populations, allied to the scalability and usability of the test in community memory clinics, supports future application of the 4MT

  3. Ultrasonic Measurement of Change in Elasticity due to Endothelium Dependent Relaxation Response by Accurate Detection of Artery-Wall Boundary

    NASA Astrophysics Data System (ADS)

    Kaneko, Takuya; Hasegawa, Hideyuki; Kanai, Hiroshi

    2007-07-01

    Ross hypothesized that an endothelial dysfunction is considered to be an initial step in atherosclerosis. Endothelial cells, which release nitric oxide (NO) in response to shear stress from blood flow, have a function of relaxing smooth muscle in the media of the arterial wall. For the assessment of the endothelial function, there is a conventional method in which the change in the diameter of the brachial artery caused by flow-mediated dilation (FMD) is measured with ultrasound. However, despite the fact that the collagen-rich hard adventitia does not respond to NO, the conventional method measures the change in diameter depending on the mechanical property of the entire wall including the adventitia. Therefore, we developed a method of measuring the change in the thickness and the elasticity of the brachial artery during a cardiac cycle using the phased tracking method for the evaluation of the mechanical property of only the intima-media region. In this study, the initial positions of echoes from the lumen-intima and media-adventitia boundaries are determined using complex template matching to accurately estimate the minute change in the thickness and the elasticity of the brachial and radial arteries. The ambiguity in the determination of such boundaries was eliminated using complex template matching, and the change in elasticity measured by the proposed method was larger than the change in inner diameter obtained by the conventional method.

  4. The velocity dependence of X-ray emission due to Charge Exchange: Applications in the Cygnus Loop

    NASA Astrophysics Data System (ADS)

    Cumbee, Renata; Lyons, David; Mullen, Patrick; Shelton, Robin L.; Stancil, Phillip C.; Schultz, David R.

    2016-04-01

    The fundamental collisional process of charge exchange (CX) has been been established as a primary source of X-ray emission from the heliosphere [1], planetary exospheres [2], and supernova remnants [3,4]. In this process, X-ray emission results from the capture of an electron by a highly charged ion from a neutral atom or molecule, to form a highly-excited, high charge state ion. As the captured electron cascades down to the lowest energy level, photons are emitted, including X-rays.To provide reliable CX-induced X-ray spectral models to realistically simulate high-energy astrophysical environments, line ratios and spectra are computed using theoretical CX cross-sections obtained with the multi-channel Landau-Zener, atomic-orbital close-coupling, and classical-trajectory Monte Carlo methods for various collisional velocities. Collisions of bare and H-like C to Al ions with H, He, and H2 are considered. Using these line ratios, XSPEC models of CX emission in the northeast rim of the Cygnus Loop supernova remnant will be shown as an example with ion velocity dependence.[1] Henley, D. B. & Shelton, R. L. 2010, ApJSS, 187, 388[2] Dennerl, K. et al. 2002, A&A 386, 319[3] Katsuda, S. et al. 2011, ApJ 730 24[4] Cumbee, R. S. et al. 2014, ApJ 787 L31

  5. Dependence of implantation sequence on surface blistering characteristics due to H and He ions co-implanted in silicon

    NASA Astrophysics Data System (ADS)

    Liang, J. H.; Hsieh, H. Y.; Wu, C. W.; Lin, C. M.

    2015-12-01

    This study investigated surface blistering characteristics due to H and He ions co-implanted in silicon at room temperature. The H and He ion energies were 40 and 50 keV, respectively, so that their depth profiles were similar. The total implantation fluence for the H and He ions was 5 × 1016 cm-2 under various fluence fractions in the H ions. The implantation sequences under investigation were He + H and H + He. Dynamic optical microscopy (DOM) was employed in order to dynamically analyze surface blistering characteristics. This study used DOM data to construct so-called time-temperature-transformation (T-T-T) curves to easily predict blistering and crater transformation at specific annealing times and temperatures. The results revealed that the curves of blister initialization, crater initialization, and crater completion in the He + H implant occurred at a lower annealing temperature but with a longer annealing time compared to those in the H + He implant. Furthermore, the threshold annealing temperatures for blister and crater formation in the He + H implant were lower than they were in the H + He implant. The size distributions of the blisters and craters in the He + H implant extended wider than those in the H + He implant. In addition, the He + H implant exhibited larger blisters and craters compared to the ones in the H + He implant. Since the former has a higher percentage of exfoliation area than the latter, it is regarded as the more optimal implantation sequence.

  6. The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1

    PubMed Central

    Scharer, Gunter; Brocker, Chad; Vasiliou, Vasilis; Creadon-Swindell, Geralyn; Gallagher, Renata C.; Spector, Elaine

    2011-01-01

    Pyridoxine-dependent epilepsy is a disorder associated with severe seizures that may be caused by deficient activity of α-aminoadipic semialdehyde dehydrogenase, encoded by the ALDH7A1 gene, with accumulation of α-aminoadipic semialdehyde and piperideine-6-carboxylic acid. The latter reacts with pyridoxal-phosphate, explaining the effective treatment with pyridoxine. We report the clinical phenotype of three patients, their mutations and those of 12 additional patients identified in our clinical molecular laboratory. There were six missense, one nonsense, and five splice-site mutations, and two small deletions. Mutations c.1217_1218delAT, I431F, IVS-1(+2)T>G, IVS-2(+1)G>A, and IVS-12(+1)G>A are novel. Some disease alleles were recurring: E399Q (eight times), G477R (six times), R82X (two times), and c.1217_1218delAT (two times). A systematic review of mutations from the literature indicates that missense mutations cluster around exons 14, 15, and 16. Nine mutations represent 61% of alleles. Molecular modeling of missense mutations allows classification into three groups: those that affect NAD+binding or catalysis, those that affect the substrate binding site, and those that affect multimerization. There are three clinical phenotypes: patients with complete seizure control with pyridoxine and normal developmental outcome (group 1) including our first patient; patients with complete seizure control with pyridoxine but with developmental delay (group 2), including our other two patients; and patients with persistent seizures despite pyridoxine treatment and with developmental delay (group 3). There is preliminary evidence for a genotype-phenotype correlation with patients from group 1 having mutations with residual activity. There is evidence from patients with similar genotypes for nongenetic factors contributing to the phenotypic spectrum. PMID:20814824

  7. Light and Nutrient Dependent Responses in Secondary Metabolites of Plantago lanceolata Offspring Are Due to Phenotypic Plasticity in Experimental Grasslands

    PubMed Central

    Miehe-Steier, Annegret; Roscher, Christiane; Reichelt, Michael; Gershenzon, Jonathan; Unsicker, Sybille B.

    2015-01-01

    A few studies in the past have shown that plant diversity in terms of species richness and functional composition can modify plant defense chemistry. However, it is not yet clear to what extent genetic differentiation of plant chemotypes or phenotypic plasticity in response to diversity-induced variation in growth conditions or a combination of both is responsible for this pattern. We collected seed families of ribwort plantain (Plantago lanceolata) from six-year old experimental grasslands of varying plant diversity (Jena Experiment). The offspring of these seed families was grown under standardized conditions with two levels of light and nutrients. The iridoid glycosides, catalpol and aucubin, and verbascoside, a caffeoyl phenylethanoid glycoside, were measured in roots and shoots. Although offspring of different seed families differed in the tissue concentrations of defensive metabolites, plant diversity in the mothers' environment did not explain the variation in the measured defensive metabolites of P. lanceolata offspring. However secondary metabolite levels in roots and shoots were strongly affected by light and nutrient availability. Highest concentrations of iridoid glycosides and verbascoside were found under high light conditions, and nutrient availability had positive effects on iridoid glycoside concentrations in plants grown under high light conditions. However, verbascoside concentrations decreased under high levels of nutrients irrespective of light. The data from our greenhouse study show that phenotypic plasticity in response to environmental variation rather than genetic differentiation in response to plant community diversity is responsible for variation in secondary metabolite concentrations of P. lanceolata in the six-year old communities of the grassland biodiversity experiment. Due to its large phenotypic plasticity P. lanceolata has the potential for a fast and efficient adjustment to varying environmental conditions in plant communities of

  8. Linear MHD Wave Propagation in Time-Dependent Flux Tube. III. Leaky Waves in Zero-Beta Plasma

    NASA Astrophysics Data System (ADS)

    Williamson, A.; Erdélyi, R.

    2016-01-01

    In this article, we evaluate the time-dependent wave properties and the damping rate of propagating fast magneto-hydrodynamic (MHD) waves when energy leakage into a magnetised atmosphere is considered. By considering a cold plasma, initial investigations into the evolution of MHD wave damping through this energy leakage will take place. The time-dependent governing equations have been derived previously in Williamson and Erdélyi (2014a, Solar Phys. 289, 899 - 909) and are now solved when the assumption of evanescent wave propagation in the outside of the waveguide is relaxed. The dispersion relation for leaky waves applicable to a straight magnetic field is determined in both an arbitrary tube and a thin-tube approximation. By analytically solving the dispersion relation in the thin-tube approximation, the explicit expressions for the temporal evolution of the dynamic frequency and wavenumber are determined. The damping rate is, then, obtained from the dispersion relation and is shown to decrease as the density ratio increases. By comparing the decrease in damping rate to the increase in damping for a stationary system, as shown, we aim to point out that energy leakage may not be as efficient a damping mechanism as previously thought.

  9. Fermentation of xylose causes inefficient metabolic state due to carbon/energy starvation and reduced glycolytic flux in recombinant industrial Saccharomyces cerevisiae.

    PubMed

    Matsushika, Akinori; Nagashima, Atsushi; Goshima, Tetsuya; Hoshino, Tamotsu

    2013-01-01

    In the present study, comprehensive, quantitative metabolome analysis was carried out on the recombinant glucose/xylose-cofermenting S. cerevisiae strain MA-R4 during fermentation with different carbon sources, including glucose, xylose, or glucose/xylose mixtures. Capillary electrophoresis time-of-flight mass spectrometry was used to determine the intracellular pools of metabolites from the central carbon pathways, energy metabolism pathways, and the levels of twenty amino acids. When xylose instead of glucose was metabolized by MA-R4, glycolytic metabolites including 3- phosphoglycerate, 2- phosphoglycerate, phosphoenolpyruvate, and pyruvate were dramatically reduced, while conversely, most pentose phosphate pathway metabolites such as sedoheptulose 7- phosphate and ribulose 5-phosphate were greatly increased. These results suggest that the low metabolic activity of glycolysis and the pool of pentose phosphate pathway intermediates are potential limiting factors in xylose utilization. It was further demonstrated that during xylose fermentation, about half of the twenty amino acids declined, and the adenylate/guanylate energy charge was impacted due to markedly decreased adenosine triphosphate/adenosine monophosphate and guanosine triphosphate/guanosine monophosphate ratios, implying that the fermentation of xylose leads to an inefficient metabolic state where the biosynthetic capabilities and energy balance are severely impaired. In addition, fermentation with xylose alone drastically increased the level of citrate in the tricarboxylic acid cycle and increased the aromatic amino acids tryptophan and tyrosine, strongly supporting the view that carbon starvation was induced. Interestingly, fermentation with xylose alone also increased the synthesis of the polyamine spermidine and its precursor S-adenosylmethionine. Thus, differences in carbon substrates, including glucose and xylose in the fermentation medium, strongly influenced the dynamic metabolism of MA-R4

  10. Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae

    PubMed Central

    Matsushika, Akinori; Nagashima, Atsushi; Goshima, Tetsuya; Hoshino, Tamotsu

    2013-01-01

    In the present study, comprehensive, quantitative metabolome analysis was carried out on the recombinant glucose/xylose-cofermenting S. cerevisiae strain MA-R4 during fermentation with different carbon sources, including glucose, xylose, or glucose/xylose mixtures. Capillary electrophoresis time-of-flight mass spectrometry was used to determine the intracellular pools of metabolites from the central carbon pathways, energy metabolism pathways, and the levels of twenty amino acids. When xylose instead of glucose was metabolized by MA-R4, glycolytic metabolites including 3- phosphoglycerate, 2- phosphoglycerate, phosphoenolpyruvate, and pyruvate were dramatically reduced, while conversely, most pentose phosphate pathway metabolites such as sedoheptulose 7- phosphate and ribulose 5-phosphate were greatly increased. These results suggest that the low metabolic activity of glycolysis and the pool of pentose phosphate pathway intermediates are potential limiting factors in xylose utilization. It was further demonstrated that during xylose fermentation, about half of the twenty amino acids declined, and the adenylate/guanylate energy charge was impacted due to markedly decreased adenosine triphosphate/adenosine monophosphate and guanosine triphosphate/guanosine monophosphate ratios, implying that the fermentation of xylose leads to an inefficient metabolic state where the biosynthetic capabilities and energy balance are severely impaired. In addition, fermentation with xylose alone drastically increased the level of citrate in the tricarboxylic acid cycle and increased the aromatic amino acids tryptophan and tyrosine, strongly supporting the view that carbon starvation was induced. Interestingly, fermentation with xylose alone also increased the synthesis of the polyamine spermidine and its precursor S-adenosylmethionine. Thus, differences in carbon substrates, including glucose and xylose in the fermentation medium, strongly influenced the dynamic metabolism of MA-R4

  11. Estimates of net infiltration in arid basins and potential impacts on recharge and solute flux due to land use and vegetation change

    NASA Astrophysics Data System (ADS)

    Robertson, Wendy Marie; Sharp, John M.

    2015-03-01

    Human impacts on land use and vegetation in arid basins have, in some regions, altered infiltration, recharge, and groundwater chemistry. However, some modeling approaches currently used do not account for these effects. In the Trans-Pecos region of Texas the presence of modern water, increasing groundwater NO3- concentrations, and vadose zone cores flushed of naturally accumulated solutes belie the notion that basin groundwater is unaffected by overlying land use and vegetation change. Recharge to the Trans-Pecos basins is spatially and temporally variable, and due to human impacts it has likely changed since pre-western settlement time (circa 1850s). By using the INFIL 3.0.1 model, a spatially distributed model of net infiltration, the volume and spatial distribution of net infiltration was examined for two basins, Wild Horse/Michigan Flats and Lobo/Ryan Flats, with model simulations designed to examine the effects of irrigated agriculture and human impacts on vegetation. Model results indicate that recharge to the basins is not limited to mountain-front zones and discrete features (i.e., alluvial channels), rather, irrigation return flow contributes an estimated 6.3 × 107 m3 (408 mm) of net infiltration over 40 yrs and net infiltration on the basin floors could contribute between 7% and 11.5% of annual basin recharge. Model results also indicate that net infiltration may be higher under current vegetation regimes than in pre-western settlement conditions; the removal of thick dense grasslands in INFIL model simulations enhanced net infiltration by 48% or more. Results from distributed models (like INFIL) improve upon scientific understanding of the links between vegetation regime and hydrological processes; this is important for the sustainable management of arid basin aquifers in Texas and elsewhere.

  12. Limits to solar cycle predictability: Cross-equatorial flux plumes

    NASA Astrophysics Data System (ADS)

    Cameron, R. H.; Dasi-Espuig, M.; Jiang, J.; Işık, E.; Schmitt, D.; Schüssler, M.

    2013-09-01

    Context. Within the Babcock-Leighton framework for the solar dynamo, the strength of a cycle is expected to depend on the strength of the dipole moment or net hemispheric flux during the preceding minimum, which depends on how much flux was present in each hemisphere at the start of the previous cycle and how much net magnetic flux was transported across the equator during the cycle. Some of this transport is associated with the random walk of magnetic flux tubes subject to granular and supergranular buffeting, some of it is due to the advection caused by systematic cross-equatorial flows such as those associated with the inflows into active regions, and some crosses the equator during the emergence process. Aims: We aim to determine how much of the cross-equatorial transport is due to small-scale disorganized motions (treated as diffusion) compared with other processes such as emergence flux across the equator. Methods: We measure the cross-equatorial flux transport using Kitt Peak synoptic magnetograms, estimating both the total and diffusive fluxes. Results: Occasionally a large sunspot group, with a large tilt angle emerges crossing the equator, with flux from the two polarities in opposite hemispheres. The largest of these events carry a substantial amount of flux across the equator (compared to the magnetic flux near the poles). We call such events cross-equatorial flux plumes. There are very few such large events during a cycle, which introduces an uncertainty into the determination of the amount of magnetic flux transported across the equator in any particular cycle. As the amount of flux which crosses the equator determines the amount of net flux in each hemisphere, it follows that the cross-equatorial plumes introduce an uncertainty in the prediction of the net flux in each hemisphere. This leads to an uncertainty in predictions of the strength of the following cycle.

  13. Pancreatic islet function in omega-3 fatty acid-depleted rats: alteration of calcium fluxes and calcium-dependent insulin release.

    PubMed

    Zhang, Y; Oguzhan, B; Louchami, K; Chardigny, J-M; Portois, L; Carpentier, Y A; Malaisse, W J; Herchuelz, A; Sener, A

    2006-09-01

    Considering the insufficient supply of long-chain polyunsaturated omega-3 fatty acids often prevailing in Western populations, this report deals mainly with alterations of Ca(2+) fluxes and Ca(2+)-dependent insulin secretory events in isolated pancreatic islets from omega-3-depleted rats. In terms of (45)Ca(2+) handling, the islets from omega-3-depleted rats, compared with those from normal animals, displayed an unaltered responsiveness to an increase in extracellular K(+) concentration, a lower inflow rate and lower fractional outflow rate of the divalent cation, and higher (45)Ca(2+)-labeled cellular pool(s) at isotopic equilibrium. The latter anomaly was corrected 120 min after intravenous injection of a novel medium-chain triglyceride-fish oil (MCT:FO) emulsion, distinct from a control omega-3-poor MCT-olive oil (MCT:OO) emulsion. At 8.3 mM D-glucose, insulin release was higher in islets from omega-3-depleted rats vs. control animals, coinciding with a higher cytosolic Ca(2+) concentration. The relative magnitude of the increase in insulin output attributable to a rise in D-glucose as well as extracellular Ca(2+) or K(+) concentration, to the absence vs. presence of verapamil and to the presence vs. absence of extracellular Ca(2+), theophylline, phorbol 12-myristate 13-acetate, or Ba(2+), was always more pronounced in islets from omega-3-depleted rats injected with the MCT:OO compared with the MCT:FO emulsion. A comparable situation prevailed when comparing islets from noninjected omega-3-depleted and normal rats. In light of these and previous findings, we propose that an impairment of Na(+),K(+)-ATPase activity plays a major, although not an exclusive, role in the perturbation of Ca(2+) fluxes and Ca(2+)-dependent secretory events in the islets from omega-3-depleted rats. PMID:16912059

  14. Reconnecting Flux Ropes

    NASA Astrophysics Data System (ADS)

    Gekelman, Walter; van Compernolle, Bart

    2012-10-01

    Magnetic flux ropes are due to helical currents and form a dense carpet of arches on the surface of the sun. Occasionally one tears loose as a coronal mass ejection and its rope structure is detected by satellites close to the earth. Current sheets can tear into filaments and these are nothing other than flux ropes. Ropes are not static, they exert mutual JxB forces causing them to twist about each other and merge. Kink instabilities cause them to violently smash into each other and reconnect at the point of contact. We report on experiments done in the large plasma device (LAPD) at UCLA (L=17m,dia=60cm,0.3<=B0z<=2.5kG,n˜2x10^12cm-3)on three dimensional flux ropes. Two, three or more magnetic flux ropes are generated from initially adjacent pulsed current channels in a background magnetized plasma. The currents and magnetic fields form exotic shapes with no ignorable direction and no magnetic nulls. Volumetric space-time data show multiple reconnection sites with time-dependent locations. The concept of a quasi-separatrix layer (QSL), a tool to understand 3D reconnection without null points. In our experiment the QSL is a narrow ribbon-like region(s) that twists between field lines. Within the QSL(s) field lines that start close to one another rapidly diverge as they pass through one or more reconnection regions. When the field lines are tracked they are observed to slip along the QSL when reconnection occurs. The Heating and other co-existing waves will be presented.

  15. RETRACTION: Unsteady flow and heat transfer of viscous incompressible fluid with temperature-dependent viscosity due to a rotating disc in a porous medium

    NASA Astrophysics Data System (ADS)

    Attia, H. A.

    2007-04-01

    It has come to the attention of the Institute of Physics that this article should not have been submitted for publication owing to its plagiarism of an earlier paper (Hossain A, Hossain M A and Wilson M 2001 Unsteady flow of viscous incompressible fluid with temperature-dependent viscosity due to a rotating disc in presence of transverse magnetic field and heat transfer Int. J. Therm. Sci. 40 11-20). Therefore this article has been retracted by the Institute of Physics and by the author, Hazem Ali Attia.

  16. Heat flux viscosity in collisional magnetized plasmas

    SciTech Connect

    Liu, C.; Fox, W.; Bhattacharjee, A.

    2015-05-15

    Momentum transport in collisional magnetized plasmas due to gradients in the heat flux, a “heat flux viscosity,” is demonstrated. Even though no net particle flux is associated with a heat flux, in a plasma there can still be momentum transport owing to the velocity dependence of the Coulomb collision frequency, analogous to the thermal force. This heat-flux viscosity may play an important role in numerous plasma environments, in particular, in strongly driven high-energy-density plasma, where strong heat flux can dominate over ordinary plasma flows. The heat flux viscosity can influence the dynamics of the magnetic field in plasmas through the generalized Ohm's law and may therefore play an important role as a dissipation mechanism allowing magnetic field line reconnection. The heat flux viscosity is calculated directly using the finite-difference method of Epperlein and Haines [Phys. Fluids 29, 1029 (1986)], which is shown to be more accurate than Braginskii's method [S. I. Braginskii, Rev. Plasma Phys. 1, 205 (1965)], and confirmed with one-dimensional collisional particle-in-cell simulations. The resulting transport coefficients are tabulated for ease of application.

  17. Heat flux viscosity in collisional magnetized plasmas

    NASA Astrophysics Data System (ADS)

    Liu, C.; Fox, W.; Bhattacharjee, A.

    2015-05-01

    Momentum transport in collisional magnetized plasmas due to gradients in the heat flux, a "heat flux viscosity," is demonstrated. Even though no net particle flux is associated with a heat flux, in a plasma there can still be momentum transport owing to the velocity dependence of the Coulomb collision frequency, analogous to the thermal force. This heat-flux viscosity may play an important role in numerous plasma environments, in particular, in strongly driven high-energy-density plasma, where strong heat flux can dominate over ordinary plasma flows. The heat flux viscosity can influence the dynamics of the magnetic field in plasmas through the generalized Ohm's law and may therefore play an important role as a dissipation mechanism allowing magnetic field line reconnection. The heat flux viscosity is calculated directly using the finite-difference method of Epperlein and Haines [Phys. Fluids 29, 1029 (1986)], which is shown to be more accurate than Braginskii's method [S. I. Braginskii, Rev. Plasma Phys. 1, 205 (1965)], and confirmed with one-dimensional collisional particle-in-cell simulations. The resulting transport coefficients are tabulated for ease of application.

  18. Analysis of the uncertainties associated with the age-dependent thyroid doses and risk of thyroid cancer due to exposure to {sup 131}I

    SciTech Connect

    Hoffman, F.O.; Apostoaei, A.I.; Nair, S.K.

    1996-06-01

    Effects on the thyroid gland due to exposure to {sup 131}I are currently of interest for ongoing retrospective studies of historical releases in Oak Ridge, Tennessee, and Hanford, Washington. Most of the work to date has been limited to dose estimation. This work focuses on estimating both dose and risk of thyroid cancer to an exposed individual. The age-dependent thyroid dose is calculated using a standard metabolic model for iodine. Updated information on thyroid mass from measurements using modem ultrasound techniques was used. The age-dependent risk is calculated using a linear excess relative risk model. An analysis of uncertainties in dose and risk estimates was performed for an individual in a population characterized by the mass of thyroid, by the iodine metabolic parameters, by the background incidence of thyroid cancer and by the excess relative risk per Gy of absorbed dose. The uncertainty analysis was performed using Monte-Carlo simulation, by considering the age-dependent parameters as random functions. The correlation between the metabolic age-dependent parameters was considered explicitly. Special attention is given to a modifying factor that accounts for the effectiveness of {sup 131}I in inducing thyroid cancer as compared to gamma irradiation, for which most of the excess risk factors are derived. This factor is based on review of recent literature and on informal interviews with outside experts, and thus, the expressed uncertainty is subjective in nature. The paper summarizes the age-dependent dose conversion factors (Sv Bq{sup -1}) and slope factors (risk Bq{sup -1}) as well as the uncertainty associated with them. An analysis that identifies the parameters of dominant importance by their contributions to the overall uncertainty is also included.

  19. Time-dependent convection models of mantle thermal structure constrained by seismic tomography and geodynamics: implications for mantle plume dynamics and CMB heat flux

    NASA Astrophysics Data System (ADS)

    Glišović, P.; Forte, A. M.; Moucha, R.

    2012-08-01

    surface plates and a rigid surface. The thermal interpretation of seismic tomography models does not provide a radial profile of the horizontally averaged temperature (i.e. the geotherm) in the mantle. One important goal of this study is to obtain a steady-state geotherm with boundary layers which satisfies energy balance of the system and provides the starting point for more realistic numerical simulations of the Earth's evolution. We obtain surface heat flux in the range of Earth-like values : 37 TW for a rigid surface and 44 TW for a surface with tectonic plates coupled to the mantle flow. Also, our convection simulations deliver CMB heat flux that is on the high end of previously estimated values, namely 13 TW and 20 TW, for rigid and plate-like surface boundary conditions, respectively. We finally employ these two end-member surface boundary conditions to explore the very-long-time scale evolution of convection over billion-year time windows. These billion-year-scale simulations will allow us to determine the extent to which a 'memory' of the starting tomography-based thermal structure is preserved and hence to explore the longevity of the structures in the present-day mantle. The two surface boundary conditions, along with the geodynamically inferred radial viscosity profiles, yield steady-state convective flows that are dominated by long wavelengths throughout the lower mantle. The rigid-surface condition yields a spectrum of mantle heterogeneity dominated by spherical harmonic degree 3 and 4, and the plate-like surface condition yields a pattern dominated by degree 1. Our exploration of the time-dependence of the spatial heterogeneity shows that, for both types of surface boundary condition, deep-mantle hot upwellings resolved in the present-day tomography model are durable and stable features. These deeply rooted mantle plumes show remarkable longevity over very long geological time spans, mainly owing to the geodynamically inferred high viscosity in the lower

  20. Kinetics of olfactory responses might largely depend on the odorant-receptor interaction and the odorant deactivation postulated for flux detectors.

    PubMed

    Kaissling, Karl-Ernst

    2013-11-01

    Experimental data together with modeling of pheromone perireceptor and receptor events in moths (Bombyx mori, Antheraea polyphemus) suggest that the kinetics of olfactory receptor potentials largely depend on the association of the odorant with the neuronal receptor molecules and the deactivation of the odorant accumulated around the receptor neuron. The first process could be responsible for the reaction times (mean about 400 ms) of the nerve impulses at threshold. The second process has been postulated for flux detectors such as olfactory sensilla of moths. The odorant deactivation could involve a modification of the pheromone-binding protein (PBP) that "locks" the pheromone inside the inner binding cavity of the protein. The model combines seemingly contradictory functions of the PBP such as pheromone transport, protection of the pheromone from enzymatic degradation, pheromone deactivation, and pheromone-receptor interaction. Model calculations reveal a density of at least 6,000 receptor molecules per µm(2) of neuronal membrane. The volatile decanoyl-thio-1,1,1-trifluoropropanone specifically blocks pheromone receptor neurons, probably when bound to the PBP and by competitive binding to the receptor molecules. The shallow dose-response curve of the receptor potential and altered response properties observed with pheromone derivatives or after adaptation may indicate shortened opening of ion channels. PMID:23563709

  1. Flux attenuation at NREL's High-Flux Solar Furnace

    NASA Astrophysics Data System (ADS)

    Bingham, Carl E.; Scholl, Kent L.; Lewandowski, Allan A.

    1994-10-01

    The High-Flux Solar Furnace (HFSF) at the National Renewable Energy Laboratory (NREL) has a faceted primary concentrator and a long focal-length-to-diameter ratio (due to its off-axis design). Each primary facet can be aimed individually to produce different flux distributions at the target plane. Two different types of attenuators are used depending on the flux distribution. A sliding-plate attenuator is used primarily when the facets are aimed at the same target point. The alternate attenuator resembles a venetian blind. Both attenuators are located between the concentrator and the focal point. The venetian-blind attenuator is primarily used to control the levels of sunlight failing on a target when the primary concentrators are not focused to a single point. This paper will demonstrate the problem of using the sliding-plate attenuator with a faceted concentrator when the facets are not aimed at the same target point. We will show that although the alternate attenuator necessarily blocks a certain amount of incoming sunlight, even when fully open, it provides a more even attenuation of the flux for alternate aiming strategies.

  2. Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion.

    PubMed

    Iwase, Akira; Kotani, Tomomi; Goto, Maki; Kobayashi, Hiroharu; Takikawa, Sachiko; Nakahara, Tatsuo; Nakamura, Tomoko; Kondo, Mika; Bayasula; Nagatomo, Yoshinari; Kikkawa, Fumitaka

    2014-01-01

    A reduced response to progesterone in the eutopic endometrium with endometriosis and in endometriotic tissues is considered to be the underlying factor for endometriosis. CD10 is known to be expressed by endometrial and endometriotic stromal cells and may be induced by progestins, although the function of CD10 is not fully revealed in endometrial or endometriotic tissues. In the current study, the expression of CD10 was significantly increased by treatment of the cells with progesterone, 17β-estradiol, and dibutyryl cyclic adenosine monophosphate (cAMP) in the endometrial stromal cells. On the other hand, the expression of CD10 following treatment with progesterone, 17β-estradiol, and dibutyryl cAMP was not significantly increased in endometriotic stromal cells. The adhesion assay for endometrial and endometriotic stromal cells to hyaluronan using 5- or 6-(N-succinimidyloxycarbonyl)-fluorescein 3', 6'-diacetate-labeled cells demonstrated that the CD44-dependent adhesion of stromal cells was inhibited by CD10. As far as the induction of CD10 is concerned, the effect of progesterone was different between endometrial stromal cells and endometriotic stromal cells. CD10 might be involved in the development of endometriosis due to its influence on CD44-dependent cell adhesion. PMID:23653392

  3. PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.

    PubMed

    Kasimova, Marina A; Zaydman, Mark A; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP₂), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP₂ binding site that involves residues playing a key role in PIP₂-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1. PMID:25559286

  4. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

    PubMed Central

    Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4–S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1. PMID:25559286

  5. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

    NASA Astrophysics Data System (ADS)

    Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

    2015-01-01

    Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1.

  6. Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

    PubMed Central

    Ye, Liang; Morse, Leslie R.; Zhang, Li; Sasaki, Hajime; Mills, Jason C.; Odgren, Paul R.; Sibbel, Greg; Stanley, James R. L.; Wong, Gee; Zamarioli, Ariane; Battaglino, Ricardo A.

    2015-01-01

    Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked out in osteoclasts. Endocytosis is severely defective in Snx10-deficent osteoclasts, as is extracellular acidification, ruffled border formation, and bone resorption. We also discovered that Snx10 is highly expressed in stomach epithelium, with mutations leading to high stomach pH and low calcium solubilization. Global Snx10-deficiency in mice results in a combined phenotype: osteopetrosis (due to osteoclast defect) and rickets (due to high stomach pH and low calcium availability, resulting in impaired bone mineralization). Osteopetrorickets, the paradoxical association of insufficient mineralization in the context of a positive total body calcium balance, is thought to occur due to the inability of the osteoclasts to maintain normal calcium–phosphorus homeostasis. However, osteoclast-specific Snx10 knockout had no effect on calcium balance, and therefore led to severe osteopetrosis without rickets. Moreover, supplementation with calcium gluconate rescued mice from the rachitic phenotype and dramatically extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis that has previously gone unrecognized. We conclude that tissue-specific effects of Snx10 mutation need to be considered in clinical approaches to this disease entity. Reliance solely on hematopoietic stem cell transplantation can leave hypocalcemia uncorrected with sometimes fatal consequences. These studies established an essential role for Snx10 in bone homeostasis and underscore the importance of gastric acidification in calcium uptake. PMID:25811986

  7. The energy dependence of the cosmic-ray neutron leakage flux in the range 0.01-10 MeV.

    NASA Technical Reports Server (NTRS)

    Jenkins, R. W.; Ifedili, S. O.; Lockwood, J. A.; Razdan, H.

    1971-01-01

    Measurement of the cosmic-ray neutron leakage flux and energy spectrum in the range 1 to 10 MeV by a neutron detector on the Ogo 6 satellite from June 7 to Sept. 30, 1969. The same detector simultaneously measured the total leakage flux, having 75% of its response to the leakage flux in the interval from 1 keV to 1 MeV. For a neutron energy spectrum of the form AE to the minus gamma in the range from 1 to 10 MeV, the upper limit to gamma for polar regions was found to be 1.0 and for the equatorial regions was 1.2. For the polar regions, the lower limit to gamma was found to be 0.8. This energy spectrum at 1 to 10 MeV is slightly flatter than Newkirk (1963) predicted.

  8. O2-dependent K+ fluxes in trout red blood cells: the nature of O2 sensing revealed by the O2 affinity, cooperativity and pH dependence of transport

    PubMed Central

    Berenbrink, Michael; Völkel, Susanne; Heisler, Norbert; Nikinmaa, Mikko

    2000-01-01

    The effects of pH and O2 tension on the isotonic ouabain-resistant K+ (Rb+) flux pathway and on haemoglobin O2 binding were studied in trout red blood cells (RBCs) in order to test for a direct effect of haemoglobin O2 saturation on K+ transport across the RBC membrane. At pH values corresponding to in vivo control arterial plasma pH and higher, elevation of the O2 partial pressure (PO2) from 7.8 to 157 mmHg increased unidirectional K+ influx across the RBC membrane several-fold. At lower extracellular pH values, stimulation of K+ influx by O2 was depressed, exhibiting an apparent pKa (pK′a) for the process of 8.0. Under similar conditions the pK′a for acid-induced deoxygenation of haemoglobin (Hb) was 7.3. When trout RBCs were exposed to PO2 values between 0 and 747 mmHg, O2 equilibrium curves typical of Hb O2 saturation were also obtained for K+ influx and efflux. However, at pH 7.9, the PO2 for half-maximal K+ efflux and K+ influx (P50) was about 8- to 12-fold higher than the P50 for Hb-O2 binding. While K+ influx and efflux stimulation by O2 was essentially non-cooperative, Hb-O2 equilibrium curves were distinctly sigmoidal (Hill parameters close to 1 and 3, respectively). O2-stimulated K+ influx and efflux were strongly pH dependent. When the definition of the Bohr factor for respiratory pigments (Φ =ΔlogP50×ΔpH−1) was extended to the effect of pH on O2-dependent K+ influx and efflux, extracellular Bohr factors (Φo) of -2.00 and -2.06 were obtained, values much higher than that for Hb (Φo = -0.49). The results of this study are consistent with an O2 sensing mechanism differing markedly in affinity and cooperativity of O2 binding, as well as in pH sensitivity, from bulk Hb. PMID:10878100

  9. Video Meteor Fluxes

    NASA Technical Reports Server (NTRS)

    Campbell-Brown, M. D.; Braid, D.

    2011-01-01

    estimate the flux (Love & Brownlee, 1993); here the physical area of the detector is well known, but the masses depend strongly on the unknown velocity distribution. In the same size range, Thomas & Netherway (1989) used the narrow-beam radar at Jindalee to calculate the flux of sporadics. In between these very large and very small sizes, a number of video and photographic observations were reduced by Ceplecha (2001). These fluxes were calculated (details are given in Ceplecha, 1988) taking the Halliday et al. (1984) MORP fireball fluxes, slightly corrected in mass, as a calibration, and adjusting the flux of small cameras to overlap with the number/mass relation from that work.

  10. EFFECTS OF ULTRAVIOLET-B IRRADIANCE ON SOYBEAN. V. THE DEPENDENCE OF PLANT SENSITIVITY ON THE PHOTOSYNTHETIC PHOTON FLUX DENSITY DURING AND AFTER LEAF EXPANSION

    EPA Science Inventory

    Soybeans (Glycine max (L.) Merr. cv Essex) were grown in a green house, and the first trifoliate leaf was either allowed to expand under a high photosynthetic photon flux density (PPFD) (1.4 millimoled per square meter per second) or a low PPFD (0.8 Millimoles per square meter pe...

  11. Fluxes of Ultrafine Particles Over and In a Deciduous Forest

    NASA Astrophysics Data System (ADS)

    Pryor, S. C.; Hornsby, K. E.

    2013-12-01

    Given the importance of forests to land surface cover and particle removal (due to the very high deposition velocities and well-developed turbulence) there is a specific need to understand removal to, and in, forests. Fluxes of size-resolved and total particle number fluxes over (at 46 m) and in (at 7 m) a deciduous forest over a 14 month period are presented based on data from two Gill 3-D WindMaster Pro sonic anemometers, an Ultrafine Condensation Particle Counter (UCPC) operated at 10 Hz and a Fast Mobility Particle Sizer (FMPS) operated at 1 Hz. Size-resolved particle profiles during the same period are measured using a separate FMPS scanning at three measurement heights across the canopy (top, middle and bottom). Three methods are being applied to derive the total number and size-resolved fluxes from the UCPC and FMPS respectively; eddy covariance, inertial dissipation and the co-spectral approach. The results are integrated with fluxes of sensible heat, momentum and carbon dioxide derived using a Licor LI-7200. Results for the total number flux concentrations and the size-resolved concentrations derived using the three different approaches applied to the above canopy sampling level show a high degree of accord, but that the eddy-covariance fluxes are generally of smaller magnitude than those derived using the spectral methods. In keeping with prior research our results show a considerable number of fluxes are characterized by upward fluxes. Further our results show distinctly different flux diurnal profiles for the nucleation versus Aitken mode particles indicating some differential control on fluxes of particles of different sizes (including a role for aerosol dynamics). This presentation will provide details regarding the experimental approach, flux and gradient estimation methodologies, diagnose the size dependence of the fluxes, and compare and contrast the canopy and ground partitioning of the particle fluxes during leaf-on and leaf-off periods.

  12. Study of the rotational-level and temperature dependence of the quenching rate of OH fluorescence due to collisions with water molecules

    NASA Technical Reports Server (NTRS)

    Koker, Edmond B.

    1995-01-01

    The importance of the OH radical as an intermediate in many combustion reactions and in atmospheric photochemistry has led many researchers to use it as a diagnostic tool in these processes. The amount of data that has been acquired over the years for this radical is quite considerable. However, the quenching rate of OH with water molecules as a function of temperature and the rotational level of the excited state is not very well understood. The motivation of the studies undertaken is to bridge the gap between the low temperature measurements and the high temperature ones reported in the literature. The technique generally employed in these diagnostics is laser-induced fluorescence (LIF), through which rotational state selective excitation of the radical is possible. Furthermore, in a combustion medium, water is produced in abundance so that knowledge of the quenching rate of OH due to water molecules plays a crucial role in interpreting the data. In general, the precursor to an understanding of the collisional quenching rates of OH involves a characterization of the mode in which the radical is produced; the resulting rotational and translational distribution, followed by a measurement of the OH temperature; and ultimately obtaining the rate constants from the pressure dependence of the fluorescence signal. The experimental implementation of these measurements therefore involved, as a first step, the production of the OH radicals in a microwave discharge cell using water vapor as the source, wherein a hydrogen atom is abstracted from H2O. The second step involved the absorption of photons from the frequency-doubled output of a pulsed amplified, single-frequency cw ring dye laser. By tuning the laser to the peak of the transition and observing the fluorescence decay after the laser pulse, the lifetime of the OH in a particular rotational electronic state was determined (tau = 1.4 microseconds for Q(sub 1)(3)). Knowledge of this parameter led to a determination of

  13. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

    PubMed Central

    Kawanishi, J; Kato, J; Sasaki, K; Fujii, S; Watanabe, N; Niitsu, Y

    1995-01-01

    Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression or function. However, mechanisms of such abnormalities have not been fully elucidated. In this study, we demonstrated that the function of E-cadherin was completely abolished in the human gastric cancer cell line HSC-39, despite the high expression of E-cadherin, because of mutations in one of the E-cadherin-associated cytoplasmic proteins, beta-catenin. Although immunofluorescence staining of HSC-39 cells by using an anti-E-cadherin antibody (HECD-1) revealed the strong and uniform expression of E-cadherin on the cell surface, cell compaction and cell aggregation were not observed in this cell. Western blotting (immunoblotting) using HECD-1 exhibited a 120-kDa band which is equivalent to normal E-cadherin. Northern (RNA) blotting demonstrated a 4.7-kb band, the same as mature E-cadherin mRNA. Immunoprecipitation of metabolically labeled proteins with HECD-1 revealed three bands corresponding to E-cadherin, alpha-catenin, and gamma-catenin and a 79-kDa band which was apparently smaller than that of normal beta-catenin, indicating truncated beta-catenin. The 79-kDa band was immunologically identified as beta-catenin by using immunoblotting with anti-beta-catenin antibodies. Examination of beta-catenin mRNA by the reverse transcriptase-PCR method revealed a transcript which was shorter than that of normal beta-catenin. The sequencing of PCR product for beta-catenin confirmed deletion in 321 bases from nucleotides +82 to +402. Southern blotting of beta-catenin DNA disclosed mutation at the genomic level. Expression vectors of Beta-catenin were introduced into HSC-39 cells by transfection. In the obtained transfectants, E-cadherin-dependent cell-cell adhesiveness was recovered, as revealed by cell compaction, cell aggregation, and immunoflourescence staining. From these

  14. Temperature Dependence of Behavior of Interface Between Molten Sn and LiCl-KCl Eutectic Melt Due to Rising Gas Bubble

    NASA Astrophysics Data System (ADS)

    Natsui, Shungo; Nashimoto, Ryota; Takai, Hifumi; Kumagai, Takehiko; Kikuchi, Tatsuya; Suzuki, Ryosuke O.

    2016-06-01

    The behavior of the interface between molten Sn and the LiCl-KCl eutectic melt system was observed directly. We found that the transient behavior of the interface exhibits considerable temperature dependence through a change in its physical properties. The "metal film" generated in the upper molten salt phase significantly influences the shape of the interface. Although the lifetime of the metal film depends on the gas flow rate, it is not affected by the buoyancy if the interfacial tension is dominant.

  15. Muon and neutrino fluxes

    NASA Technical Reports Server (NTRS)

    Edwards, P. G.; Protheroe, R. J.

    1985-01-01

    The result of a new calculation of the atmospheric muon and neutrino fluxes and the energy spectrum of muon-neutrinos produced in individual extensive air showers (EAS) initiated by proton and gamma-ray primaries is reported. Also explained is the possibility of detecting atmospheric nu sub mu's due to gamma-rays from these sources.

  16. Topological A-type models with flux

    NASA Astrophysics Data System (ADS)

    Stojevic, Vid

    2008-05-01

    We study deformations of the A-model in the presence of fluxes, by which we mean rank-three tensors with antisymmetrized upper/lower indices, using the AKSZ construction. There are two natural deformations of the A-model in the AKSZ language: 1) the Zucchini model, which can be defined on a generalized complex manifold and reduces to the A-model when the generalized complex structure comes from a symplectic structure, and 2) a topological membrane model, which naturally accommodates fluxes, and reduces to the Zucchini model on the boundary of the membrane when the fluxes are turned off. We show that the fluxes are related to deformations of the Courant bracket which generalize the twist by a closed 3-from H, in the sense that satisfying the AKSZ master equation implies precisely the integrability conditions for an almost generalized complex structure with respect to the deformed Courant bracket. In addition, the master equation imposes conditions on the fluxes that generalize dH = 0. The membrane model can be defined on a large class of U(m)- and U(m) × U(m)-structure manifolds relevant for string theory, including geometries inspired by (1, 1) supersymmetric σ-models with additional supersymmetries due to almost complex (but not necessarily complex) structures in the target space. In addition we show that the model can be defined on three particular half-flat manifolds related to the Iwasawa manifold. When only the closed 3-form flux is turned on it is possible to obtain a topological string model, which we do for the case of a Calabi-Yau. We argue that deformations from the standard A-model are due to the choice of gauge fixing fermion, rather than a flux deformation of the AKSZ action. The particularly interesting cases arise when the fermion depends on auxiliary fields, the simplest possibility being due to the (2, 0)+(0, 2) component of a non-trivial b-field. The model is generically no longer evaluated on holomorphic maps and defines new topological

  17. Dependence of the flux-creep activation energy on current density and magnetic field for a Ca10(Pt3As8)[(Fe1-xPtx)2As2]5 single crystal

    NASA Astrophysics Data System (ADS)

    Ge, J.; Gutierrez, J.; Li, J.; Yuan, J.; Wang, H.-B.; Yamaura, K.; Takayama-Muromachi, E.; Moshchalkov, V. V.

    2014-03-01

    We have performed detailed ac susceptibility measurements to investigate the vortex dynamics in a Ca10(Pt3As8)[(Fe1-xPtx)2As2]5 single crystal as a function of temperature, frequency, ac amplitude, and dc field. The field dependence of the activation energy U is derived in the framework of thermally activated flux creep theory, yielding a power law dependence of U ˜ Hα with α ≈ -1.0 for H above 0.30 T, while below 0.3 T U is independent of the field. The activation energy reaches 104 K at low fields, suggesting strong pinning in the material. The nonlinear function of the activation energy vs. the current density is determined, which shows logarithmic dependence U(J)∝lnJ.

  18. Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury

    PubMed Central

    Zhou, Yulong; Zhang, Hongyu; Zheng, Binbin; Ye, Libing; Zhu, Sipin; Johnson, Noah R; Wang, Zhouguang; Wei, Xiaojie; Chen, Daqing; Cao, Guodong; Fu, Xiaobing; Li, Xiaokun; Xu, Hua-Zi; Xiao, Jian

    2016-01-01

    Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) which leads to infiltration of blood cells, an inflammatory response, and neuronal cell death, resulting spinal cord secondary damage. Retinoic acid (RA) has a neuroprotective effect in both ischemic brain injury and SCI, however the relationship between BSCB disruption and RA in SCI is still unclear. In this study, we demonstrated that autophagy and ER stress are involved in the protective effect of RA on the BSCB. RA attenuated BSCB permeability and decreased the loss of tight junction (TJ) molecules such as P120, β-catenin, Occludin and Claudin5 after injury in vivo as well as in Brain Microvascular Endothelial Cells (BMECs). Moreover, RA administration improved functional recovery in the rat model of SCI. RA inhibited the expression of CHOP and caspase-12 by induction of autophagic flux. However, RA had no significant effect on protein expression of GRP78 and PDI. Furthermore, combining RA with the autophagy inhibitor chloroquine (CQ) partially abolished its protective effect on the BSCB via exacerbated ER stress and subsequent loss of tight junctions. Taken together, the neuroprotective role of RA in recovery from SCI is related to prevention of of BSCB disruption via the activation of autophagic flux and the inhibition of ER stress-induced cell apoptosis. These findings lay the groundwork for future translational studies of RA for CNS diseases, especially those related to BSCB disruption. PMID:26722220

  19. Angular dependence of the flux pinning for YBa{sub 2}Cu{sub 3}O{sub y}/PrBa{sub 2}Cu{sub 3}O{sub y} superlattice

    SciTech Connect

    Horng, H.E.; Wu, J.M.; Yang, H.C.

    1997-06-01

    The angular dependence of the magnetic relaxation for YBa{sub 2}Cu{sub 3}O{sub y}/PrBa{sub 2}Cu{sub 3}O{sub y} (YBCO/PBCO) superlattice was measured under magnetic field to investigate the flux pinning. The applied magnetic field was 0.1 Tesla. The direction of the applied magnetic field makes an angle of 10{degrees}, 20{degrees}, 30{degrees}, 45{degrees}... with the c-axis of YBCO/PBCO superlattice. Based on the Anderson-Kim model the authors derive the pinning energy of this film. The pinning energy is angular independent. The results are discussed.

  20. Hysteretic Dependence of Magnetic Flux Density on Primary AC Current in Flat-Type Inductive Fault Current Limiter with YBCO Thin Film Discs

    NASA Astrophysics Data System (ADS)

    Harada, Masayuki; Yokomizu, Yasunobu; Matsumura, Toshiro

    2014-05-01

    This paper focuses on a flat-type inductive superconducting FCL (FIS-FCL) consisting of a pancake coil and a YBCO thin layer disc. AC current injection experiments and magnetic field analysis were carried out for two kinds of FIS-FCL, single-disc model and double-discs model. In the former, the pancake coil was putted on the YBCO disc. In the latter, the pancake coil was sandwiched with two YBCO discs. The double-discs model cancels out the magnetic flux density more effectively than the single-disc model. In the double-discs model, the superconducting state period is longer than in the single-disc model. Thus, it may be concluded that the double-discs model is considered to be suitable for FIS-FCL.

  1. Rotation dependence of a phase delay between plasma edge electron density and temperature fields due to a fast rotating, resonant magnetic perturbation field

    SciTech Connect

    Stoschus, H.; Schmitz, O.; Frerichs, H.; Unterberg, B.; Abdullaev, S. S.; Clever, M.; Coenen, J. W.; Kruezi, U.; Schega, D.; Samm, U.; Jakubowski, M. W.

    2010-06-15

    Measurements of the plasma edge electron density n{sub e} and temperature T{sub e} fields during application of a fast rotating, resonant magnetic perturbation (RMP) field show a characteristic modulation of both, n{sub e} and T{sub e} coherent to the rotation frequency of the RMP field. A phase delay PHI between the n{sub e}(t) and T{sub e}(t) waveforms is observed and it is demonstrated that this phase delay PHI is a function of the radius with PHI(r) depending on the relative rotation of the RMP field and the toroidal plasma rotation. This provides for the first time direct experimental evidence for a rotation dependent damping of the external RMP field in the edge layer of a resistive high-temperature plasma which breaks down at low rotation and high resonant field amplitudes.

  2. Ocean Winds and Turbulent Air-Sea Fluxes Inferred From Remote Sensing

    NASA Technical Reports Server (NTRS)

    Bourassa, Mark A.; Gille, Sarah T.; Jackson, Daren L.; Roberts, J. Brent; Wick, Gary A.

    2010-01-01

    Air-sea turbulent fluxes determine the exchange of momentum, heat, freshwater, and gas between the atmosphere and ocean. These exchange processes are critical to a broad range of research questions spanning length scales from meters to thousands of kilometers and time scales from hours to decades. Examples are discussed (section 2). The estimation of surface turbulent fluxes from satellite is challenging and fraught with considerable errors (section 3); however, recent developments in retrievals (section 3) will greatly reduce these errors. Goals for the future observing system are summarized in section 4. Surface fluxes are defined as the rate per unit area at which something (e.g., momentum, energy, moisture, or CO Z ) is transferred across the air/sea interface. Wind- and buoyancy-driven surface fluxes are called surface turbulent fluxes because the mixing and transport are due to turbulence. Examples of nonturbulent processes are radiative fluxes (e.g., solar radiation) and precipitation (Schmitt et al., 2010). Turbulent fluxes are strongly dependent on wind speed; therefore, observations of wind speed are critical for the calculation of all turbulent surface fluxes. Wind stress, the vertical transport of horizontal momentum, also depends on wind direction. Stress is very important for many ocean processes, including upper ocean currents (Dohan and Maximenko, 2010) and deep ocean currents (Lee et al., 2010). On short time scales, this horizontal transport is usually small compared to surface fluxes. For long-term processes, transport can be very important but again is usually small compared to surface fluxes.

  3. Magnetic flux tube tunneling

    NASA Astrophysics Data System (ADS)

    Dahlburg, R. B.; Antiochos, S. K.; Norton, D.

    1997-08-01

    We present numerical simulations of the collision and subsequent interaction of orthogonal magnetic flux tubes. The simulations were carried out using a parallelized spectral algorithm for compressible magnetohydrodynamics. It is found that, under a wide range of conditions, the flux tubes can ``tunnel'' through each other, a behavior not previously seen in studies of either vortex tube or magnetic flux tube interactions. Two conditions must be satisfied for tunneling to occur: the magnetic field must be highly twisted with a field line pitch >>1, and the Lundquist number must be somewhat large, >=2880. An examination of magnetic field lines suggests that tunneling is due to a double-reconnection mechanism. Initially orthogonal field lines reconnect at two specific locations, exchange interacting sections, and ``pass'' through each other. The implications of these results for solar and space plasmas are discussed.

  4. Magnetic flux tube tunneling

    SciTech Connect

    Dahlburg, R.B.; Antiochos, S.K.; Norton, D.

    1997-08-01

    We present numerical simulations of the collision and subsequent interaction of {ital orthogonal} magnetic flux tubes. The simulations were carried out using a parallelized spectral algorithm for compressible magnetohydrodynamics. It is found that, under a wide range of conditions, the flux tubes can {open_quotes}tunnel{close_quotes} through each other, a behavior not previously seen in studies of either vortex tube or magnetic flux tube interactions. Two conditions must be satisfied for tunneling to occur: the magnetic field must be highly twisted with a field line pitch {gt}1, and the Lundquist number must be somewhat large, {ge}2880. An examination of magnetic field lines suggests that tunneling is due to a double-reconnection mechanism. Initially orthogonal field lines reconnect at two specific locations, exchange interacting sections, and {open_quotes}pass{close_quotes} through each other. The implications of these results for solar and space plasmas are discussed. {copyright} {ital 1997} {ital The American Physical Society}

  5. Superradiance and flux conservation

    NASA Astrophysics Data System (ADS)

    Boonserm, Petarpa; Ngampitipan, Tritos; Visser, Matt

    2014-09-01

    The theoretical foundations of the phenomenon known as superradiance still continue to attract considerable attention. Despite many valiant attempts at pedagogically clear presentations, the effect nevertheless still continues to generate some significant confusion. Part of the confusion arises from the fact that superradiance in a quantum field theory context is not the same as superradiance (superfluorescence) in some condensed matter contexts; part of the confusion arises from traditional but sometimes awkward normalization conventions, and part is due to sometimes unnecessary confusion between fluxes and probabilities. We shall argue that the key point underlying the effect is flux conservation (and, in the presence of dissipation, a controlled amount of flux nonconservation), and that attempting to phrase things in terms of reflection and transmission probabilities only works in the absence of superradiance. To help clarify the situation we present a simple exactly solvable toy model exhibiting both superradiance and damping.

  6. Increased furfural tolerance due to overexpression of NADH-dependent oxidoreductase FucO in Escherichia coli strains engineered for the production of ethanol and lactate.

    PubMed

    Wang, X; Miller, E N; Yomano, L P; Zhang, X; Shanmugam, K T; Ingram, L O

    2011-08-01

    Furfural is an important fermentation inhibitor in hemicellulose sugar syrups derived from woody biomass. The metabolism of furfural by NADPH-dependent oxidoreductases, such as YqhD (low K(m) for NADPH), is proposed to inhibit the growth and fermentation of xylose in Escherichia coli by competing with biosynthesis for NADPH. The discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural provided a new approach to improve furfural tolerance. Strains that produced ethanol or lactate efficiently as primary products from xylose were developed. These strains included chromosomal mutations in yqhD expression that permitted the fermentation of xylose broths containing up to 10 mM furfural. Expression of fucO from plasmids was shown to increase furfural tolerance by 50% and to permit the fermentation of 15 mM furfural. Product yields with 15 mM furfural were equivalent to those of control strains without added furfural (85% to 90% of the theoretical maximum). These two defined genetic traits can be readily transferred to enteric biocatalysts designed to produce other products. A similar strategy that minimizes the depletion of NADPH pools by native detoxification enzymes may be generally useful for other inhibitory compounds in lignocellulosic sugar streams and with other organisms. PMID:21685167

  7. Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner

    PubMed Central

    Mnich, K; Carleton, L A; Kavanagh, E T; Doyle, K M; Samali, A; Gorman, A M

    2014-01-01

    Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the question of whether NGF can also protect against apoptosis downstream of caspase activation. NGF treatment promoted a rapid reduction in the level of the p17 subunit of active caspase-3 in PC12 cells that had been induced to undergo apoptosis by various cytotoxins. The mechanism involved TrkA-dependent activation of extracellular signal-regulated kinase (ERK1/2) but not phosphatidylinositol 3-kinase (PI3K)/Akt, and de novo protein synthesis. Involvement of inhibitor of apoptosis proteins (IAPs) and proteasomal degradation were ruled out. In contrast, inhibition of lysosome function using chloroquine and concanamycin A reversed NGF-induced removal of p17. Moreover, in NGF-treated cells, active caspases were found to be localised to lysosomes. The involvement of macroautophagy and chaperone-mediated autophagy were ruled out. Taken together, these findings suggest an anti-apoptotic mechanism by which NGF induces removal of active caspase-3 in a lysosome-dependent manner. PMID:24787014

  8. Vorticity flux from active dimples

    NASA Astrophysics Data System (ADS)

    McKeon, Beverley; Sherwin, Spencer; Morrison, Jonathan

    2004-11-01

    The effect of surface depressions, or dimples, in reducing drag on golf balls is well-known. Here this concept is extended to using ``active" dimples to manipulate vorticity flux at the wall. Surface vorticity flux is governed by surface accelerations, pressure and shear stress gradients, and surface curvature. ``Active" (or vibrating) dimples may generate vorticity flux by each of these terms, making them an excellent candidate for a basic study of flux manipulation, by which flow control may be achieved. Flow over an active dimple in fully-developed laminar channel flow is simulated with velocity boundary conditions developed from a linearized perturbation method imposed at the wall. This simple model cannot capture flow separation, but gives insight into the most straightforward means of flux generation from the concave surface. Vorticity flux due to dimple geometry and motion is quantified, and enhancements of two to three orders of magnitude in peak vorticity over the static dimple case are observed.

  9. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

    PubMed Central

    Wiersma, Valerie R; de Bruyn, Marco; Wei, Yunwei; van Ginkel, Robert J; Hirashima, Mitsuomi; Niki, Toshiro; Nishi, Nozomu; Zhou, Jin; Pouwels, Simon D; Samplonius, Douwe F; Nijman, Hans W; Eggleton, Paul; Helfrich, Wijnand; Bremer, Edwin

    2015-01-01

    Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRASmut) CRC is uniquely sensitive to treatment with recombinant LGALS9/Galectin-9 (rLGALS9), a recently established regulator of epithelial polarity. Upon treatment of CRC cells, rLGALS9 rapidly internalizes via early- and late-endosomes and accumulates in the lysosomal compartment. Treatment with rLGALS9 is accompanied by induction of frustrated autophagy in KRASmut CRC, but not in CRC with BRAF (B-Raf proto-oncogene, serine/threonine kinase) mutations (BRAFmut). In KRASmut CRC, rLGALS9 acts as a lysosomal inhibitor that inhibits autophagosome-lysosome fusion, leading to autophagosome accumulation, excessive lysosomal swelling and cell death. This antitumor activity of rLGALS9 directly correlates with elevated basal autophagic flux in KRASmut cancer cells. Thus, rLGALS9 has potent antitumor activity toward refractory KRASmut CRC cells that may be exploitable for therapeutic use. PMID:26086204

  10. Photosynthetic acclimation to drought stress in Agave salmiana Otto ex Salm-Dyck seedlings is largely dependent on thermal dissipation and enhanced electron flux to photosystem I.

    PubMed

    Campos, Huitziméngari; Trejo, Carlos; Peña-Valdivia, Cecilia B; García-Nava, Rodolfo; Conde-Martínez, F Víctor; Cruz-Ortega, Ma Del Rocío

    2014-10-01

    Agave salmiana Otto ex Salm-Dyck, a crassulacean acid metabolism plant that is adapted to water-limited environments, has great potential for bioenergy production. However, drought stress decreases the requirement for light energy, and if the amount of incident light exceeds energy consumption, the photosynthetic apparatus can be injured, thereby limiting plant growth. The objective of this study was to evaluate the effects of drought and re-watering on the photosynthetic efficiency of A. salmiana seedlings. The leaf relative water content and leaf water potential decreased to 39.6 % and -1.1 MPa, respectively, over 115 days of water withholding and recovered after re-watering. Drought caused a direct effect on photosystem II (PSII) photochemistry in light-acclimated leaves, as indicated by a decrease in the photosynthetic electron transport rate. Additionally, down-regulation of photochemical activity occurred mainly through the inactivation of PSII reaction centres and an increased thermal dissipation capacity of the leaves. Prompt fluorescence kinetics also showed a larger pool of terminal electron acceptors in photosystem I (PSI) as well as an increase in some JIP-test parameters compared to controls, reflecting an enhanced efficiency and specific fluxes for electron transport from the plastoquinone pool to the PSI terminal acceptors. All the above parameters showed similar levels after re-watering. These results suggest that the thermal dissipation of excess energy and the increased energy conservation from photons absorbed by PSII to the reduction of PSI end acceptors may be an important acclimation mechanism to protect the photosynthetic apparatus from over-excitation in Agave plants. PMID:24798124

  11. Surface Turbulent Fluxes Over Pack Ice Inferred from TOVS Observations

    NASA Technical Reports Server (NTRS)

    Lindsay, R. W.; Francis, J. A.; Persson, P. O. G.; Rothrock, D. A.; Schweiger, A. J.

    1996-01-01

    A one-dimensional, atmospheric boundary layer model is coupled to a thermodynamic ice model to estimate the surface turbulent fluxes over thick sea ice. The principal forcing parameters in this time-dependent model are the air temperature, humidity, and wind speed at a specified level (either at 2 m or at 850 mb) and the downwelling surface radiative fluxes. The free parameters. are the air temperature, humidity, and wind speed profiles below the specified level, the surface skin temperature, the ice temperature profile, and the surface turbulent fluxes. The goal is to determine how well we can estimate the turbulent surface heat and momentum fluxes using forcing parameters from atmospheric temperatures and radiative fluxes retrieved from the TIROS-N Operational Vertical Sounder (TOVS) data. Meteorological observations from the Lead Experiment (LeadEx, April 1992) ice camp are used to validate turbulent fluxes computed with the surface observations and the results are used to compare with estimates based on radio-sonde observations or with estimates based on TOVS data. We find that the TOVS-based estimates of the stress are significantly more accurate than those found with a constant geostrophic drag coefficient, with a root-mean-square error about half as large. This improvement is due to stratification effects included in the boundary layer model. The errors in the sensible heat flux estimates, however, are large compared to the small mean values observed during the field experiment.

  12. Loss of animal seed dispersal increases extinction risk in a tropical tree species due to pervasive negative density dependence across life stages.

    PubMed

    Caughlin, T Trevor; Ferguson, Jake M; Lichstein, Jeremy W; Zuidema, Pieter A; Bunyavejchewin, Sarayudh; Levey, Douglas J

    2015-01-01

    Overhunting in tropical forests reduces populations of vertebrate seed dispersers. If reduced seed dispersal has a negative impact on tree population viability, overhunting could lead to altered forest structure and dynamics, including decreased biodiversity. However, empirical data showing decreased animal-dispersed tree abundance in overhunted forests contradict demographic models which predict minimal sensitivity of tree population growth rate to early life stages. One resolution to this discrepancy is that seed dispersal determines spatial aggregation, which could have demographic consequences for all life stages. We tested the impact of dispersal loss on population viability of a tropical tree species, Miliusa horsfieldii, currently dispersed by an intact community of large mammals in a Thai forest. We evaluated the effect of spatial aggregation for all tree life stages, from seeds to adult trees, and constructed simulation models to compare population viability with and without animal-mediated seed dispersal. In simulated populations, disperser loss increased spatial aggregation by fourfold, leading to increased negative density dependence across the life cycle and a 10-fold increase in the probability of extinction. Given that the majority of tree species in tropical forests are animal-dispersed, overhunting will potentially result in forests that are fundamentally different from those existing now. PMID:25392471

  13. The analgesic and anti-inflammatory effects of shark cartilage are due to a peptide molecule and are nitric oxide (NO) system dependent.

    PubMed

    Fontenele, J B; Araújo, G B; de Alencar, J W; Viana, G S

    1997-11-01

    The present work shows an antinociceptive and dose-dependent effect of shark cartilage hydrosoluble fraction (HF) on writhing and formalin tests in mice. The effect was not altered by thalidomide, a known inhibitor of tumor necrosis factor-alfa (TNF-alfa) synthesis. Similarly, the antinociceptive effect did not change in the presence of naloxone, indicating that the opioid system is not involved. However, the effect observed was blocked by L-arginine, a NO synthesis substrate, and it was potentiated by L-NAME, suggesting a role of the NO system in the shark cartilage antinociceptive effect. Effects similar to those seen with the HF were detected with peak II from gel filtration chromatography. The increase in vascular permeability induced by serotonin in rats was significantly abolished by the HF at the dose of 2 mg/kg, p.o., and again it was not potentiated by thalidomide. The observed blockade in the vascular permeability increase induced by histamine was detected only with a higher dose (10 mg/kg, p.o.). PMID:9401722

  14. On the optimization, and the intensity dependence, of the excitation rate for the absorption of two-photons due to the direct permanent dipole moment excitation mechanism

    NASA Astrophysics Data System (ADS)

    Meath, William J.

    2016-07-01

    A model two-level dipolar molecule, and the rotating wave approximation and perturbation theory, are used to investigate the optimization and the laser intensity dependence of the two-photon excitation rate via the direct permanent dipole mechanism. The rate is proportional to the square of the laser intensity I only for small intensities and times when perturbation theory is applicable. An improvement on perturbation theory is provided by a small time RWA result for the rate which is not proportional to I2; rather it is proportional to the square of an effective intensity Ieff. For each laser intensity the optimum RWA excitation rate as a function of time, for low intensities, is proportional to I, not I2, and for high intensities it is proportional to Ieff. For a given two-photon transition the laser-molecule coupling optimizes for an intensity Imax which, for example, leads to a maximum possible excitation rate as a function of time. The validity of the RWA results of this paper, and the importance of including the effects of virtual excited states, are also discussed briefly.

  15. Loss of animal seed dispersal increases extinction risk in a tropical tree species due to pervasive negative density dependence across life stages

    PubMed Central

    Caughlin, T. Trevor; Ferguson, Jake M.; Lichstein, Jeremy W.; Zuidema, Pieter A.; Bunyavejchewin, Sarayudh; Levey, Douglas J.

    2015-01-01

    Overhunting in tropical forests reduces populations of vertebrate seed dispersers. If reduced seed dispersal has a negative impact on tree population viability, overhunting could lead to altered forest structure and dynamics, including decreased biodiversity. However, empirical data showing decreased animal-dispersed tree abundance in overhunted forests contradict demographic models which predict minimal sensitivity of tree population growth rate to early life stages. One resolution to this discrepancy is that seed dispersal determines spatial aggregation, which could have demographic consequences for all life stages. We tested the impact of dispersal loss on population viability of a tropical tree species, Miliusa horsfieldii, currently dispersed by an intact community of large mammals in a Thai forest. We evaluated the effect of spatial aggregation for all tree life stages, from seeds to adult trees, and constructed simulation models to compare population viability with and without animal-mediated seed dispersal. In simulated populations, disperser loss increased spatial aggregation by fourfold, leading to increased negative density dependence across the life cycle and a 10-fold increase in the probability of extinction. Given that the majority of tree species in tropical forests are animal-dispersed, overhunting will potentially result in forests that are fundamentally different from those existing now. PMID:25392471

  16. Spatial decoupling of agricultural production and consumption: quantifying dependences of countries on food imports due to domestic land and water constraints

    NASA Astrophysics Data System (ADS)

    Fader, Marianela; Gerten, Dieter; Krause, Michael; Lucht, Wolfgang; Cramer, Wolfgang

    2013-03-01

    In our globalizing world, the geographical locations of food production and consumption are becoming increasingly disconnected, which increases reliance on external resources and their trade. We quantified to what extent water and land constraints limit countries’ capacities, at present and by 2050, to produce on their own territory the crop products that they currently import from other countries. Scenarios of increased crop productivity and water use, cropland expansion (excluding areas prioritized for other uses) and population change are accounted for. We found that currently 16% of the world population use the opportunities of international trade to cover their demand for agricultural products. Population change may strongly increase the number of people depending on ex situ land and water resources up to about 5.2 billion (51% of world population) in the SRES A2r scenario. International trade will thus have to intensify if population growth is not accompanied by dietary change towards less resource-intensive products, by cropland expansion, or by productivity improvements, mainly in Africa and the Middle East. Up to 1.3 billion people may be at risk of food insecurity in 2050 in present low-income economies (mainly in Africa), if their economic development does not allow them to afford productivity increases, cropland expansion and/or imports from other countries.

  17. Ion fluence dependence of the total sputtering yield and differential angular sputtering yield of bismuth due to 50 keV argon ion irradiation

    NASA Astrophysics Data System (ADS)

    Deoli, Naresh T.; Phinney, Lucas C.; Weathers, Duncan L.

    2014-08-01

    The dependences of the total sputtering yield of Bi and the differential angular distribution of these sputtered Bi atoms on the fluence of 50 keV Ar+ ions at normal incidence have been experimentally measured. Polycrystalline Bi targets were used for these purposes. The collector technique and accurate current integration methods were adopted for the determination of angular distributions of sputtered Bi atoms. The ion fluence was varied from 1.9 × 1019 to 3.1 × 1020 ions/cm2. The sputtered atoms were collected on high purity aluminum foils under ultra-high vacuum (∼5 × 10-9 Torr). The collector foils were subsequently analyzed using heavy ion Rutherford backscattering spectroscopy. The shape of the angular distribution of sputtered atoms was found not to change significantly with the fluence, but the sputtering yield increased significantly from 2.2 ± 0.2 to 9.6 ± 0.6 atoms/ion over the fluence range studied.

  18. NEUTRON FLUX INTENSITY DETECTION

    DOEpatents

    Russell, J.T.

    1964-04-21

    A method of measuring the instantaneous intensity of neutron flux in the core of a nuclear reactor is described. A target gas capable of being transmuted by neutron bombardment to a product having a resonance absorption line nt a particular microwave frequency is passed through the core of the reactor. Frequency-modulated microwave energy is passed through the target gas and the attenuation of the energy due to the formation of the transmuted product is measured. (AEC)

  19. Heterotic Calabi-Yau compactifications with flux

    NASA Astrophysics Data System (ADS)

    Klaput, Michael; Lukas, Andre; Svanes, Eirik E.

    2013-09-01

    Compactifications of the heterotic string with NS flux normally require non Calabi-Yau internal spaces which are complex but no longer Kähler. We point out that this conclusion rests on the assumption of a maximally symmetric four-dimensional space-time and can be avoided if this assumption is relaxed. Specifically, it is shown that an internal Calabi-Yau manifold is consistent with the presence of NS flux provided four-dimensional space-time is taken to be a domain wall. These Calabi-Yau domain wall solutions can still be associated with a covariant four-dimensional N = 1 supergravity. In this four-dimensional context, the domain wall arises as the "simplest" solution to the effective supergravity due to the presence of a flux potential with a runaway direction. Our main message is that NS flux is a legitimate ingredient for moduli stabilisation in heterotic Calabi-Yau models. Ultimately, the success of such models depends on the ability to stabilise the runaway direction and thereby "lift" the domain wall to a maximally supersymmetric vacuum.

  20. Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.

    PubMed Central

    Considine, R V; Nyce, M R; Allen, L E; Morales, L M; Triester, S; Serrano, J; Colberg, J; Lanza-Jacoby, S; Caro, J F

    1995-01-01

    We tested the hypothesis that liver protein kinase C (PKC) is increased in non-insulin-dependent diabetes mellitus (NIDDM). To this end we examined the distribution of PKC isozymes in liver biopsies from obese individuals with and without NIDDM and in lean controls. PKC isozymes alpha, beta, epsilon and zeta were detected by immunoblotting in both the cytosol and membrane fractions. Isozymes gamma and delta were not detected. There was a significant increase in immunodetectable PKC-alpha (twofold), -epsilon (threefold), and -zeta (twofold) in the membrane fraction isolated from obese subjects with NIDDM compared with the lean controls. In obese subjects without NIDDM, the amount of membrane PKC isozymes was not different from the other two groups. We next sought an animal model where this observation could be studied further. The Zucker diabetic fatty rat offered such a model system. Immunodetectable membrane PKC-alpha, -beta, -epsilon, and -zeta were significantly increased when compared with both the lean and obese controls. The increase in immunodetectable PKC protein correlated with a 40% elevation in the activity of PKC at the membrane. Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in membrane PKC isozyme protein or kinase activity. Further, phlorizin treatment did not improve insulin receptor autophosphorylation nor did the treatment lower liver diacylglycerol. We conclude that liver PKC is increased in NIDDM, a change that is not secondary to hyperglycemia. It is possible that PKC-mediated phosphorylation of some component in the insulin signaling cascade contributes to the insulin resistance observed in NIDDM. Images PMID:7769136

  1. HEME-DEPENDENT ACTIVATION OF NEURONAL NITRIC-OXIDE SYNTHASE BY CYTOSOL IS DUE TO AN HSP70-DEPENDENT, THIOREDOXIN-MEDIATED THIOL-DISULFIDE INTERCHANGE IN THE HEME/SUBSTRATE BINDING CLEFT†

    PubMed Central

    Morishima, Yoshihiro; Lau, Miranda; Peng, Hwei-Ming; Miyata, Yoshinari; Gestwicki, Jason E.; Pratt, William B.; Osawa, Yoichi

    2011-01-01

    We have reported that heme-dependent activation of apo-neuronal nitric oxide synthase (apo-nNOS) to the active holo-enzyme dimer is dependent upon factors present in reticulocyte lysate and other cytosols. Here, we find that both Hsp70 and thioredoxin are components of the activation system. The apo-nNOS activating activity of reticulocyte lysate is retained in a pool of fractions containing Hsp70 that elute from DE52 prior to Hsp90. All of the activating activity and 20–30% of the Hsp70 elute in the flow-through fraction upon subsequent ATP-agarose chromatography. Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-μ, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation. Previous work has shown that apo-nNOS can be activated by thiol-disulfide exchange, and we show substantial activation with a small molecule dithiol modeled on the active motifs of thioredoxin and protein disulfide isomerase. Further fractionation of the ATP-agarose flow-through on Sephacryl S-300 separates free thioredoxin from apo-nNOS activating activity, Hsp70, and a small amount of thioredoxin, all of which are eluted throughout the macromolecular peak. Incubation of apo-nNOS with the macromolecular fraction in combination with either the thioredoxin-containing fraction or with purified recombinant human thioredoxin restores full heme-dependent activating activity. This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme. PMID:21755988

  2. Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

    PubMed

    Morishima, Yoshihiro; Lau, Miranda; Peng, Hwei-Ming; Miyata, Yoshinari; Gestwicki, Jason E; Pratt, William B; Osawa, Yoichi

    2011-08-23

    We have reported that heme-dependent activation of apo-neuronal nitric oxide synthase (apo-nNOS) to the active holo-enzyme dimer is dependent upon factors present in reticulocyte lysate and other cytosols. Here, we find that both Hsp70 and thioredoxin are components of the activation system. The apo-nNOS activating activity of reticulocyte lysate is retained in a pool of fractions containing Hsp70 that elute from DE52 prior to Hsp90. All of the activating activity and 20-30% of the Hsp70 elute in the flow-through fraction upon subsequent ATP-agarose chromatography. Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-μ, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation. Previous work has shown that apo-nNOS can be activated by thiol-disulfide exchange, and we show substantial activation with a small molecule dithiol modeled on the active motifs of thioredoxin and protein disulfide isomerase. Further fractionation of the ATP-agarose flow-through on Sephacryl S-300 separates free thioredoxin from apo-nNOS activating activity, Hsp70, and a small amount of thioredoxin, all of which are eluted throughout the macromolecular peak. Incubation of apo-nNOS with the macromolecular fraction in combination either with the thioredoxin-containing fraction or with purified recombinant human thioredoxin restores full heme-dependent activating activity. This supports a model in which Hsp70 binding to apo-nNOS stabilizes an open state of the heme/substrate binding cleft to facilitate thioredoxin access to the active site cysteine that coordinates with heme iron, permitting heme binding and dimerization to the active enzyme. PMID:21755988

  3. Neoclassical Angular Momentum Flux Revisited

    NASA Astrophysics Data System (ADS)

    Wong, S. K.; Chan, V. S.

    2004-11-01

    The toroidal angular momentum flux in neoclassical transport theory of small rotations depends on the second order (in ion poloidal gyroradius over plasma scale length) ion distribution function. Owing to the complexity of the calculation, the result obtained a long time ago for circular cross-section tokamak plasmas in the banana regime [M.N. Rosenbluth, et al., Plasma Physics and Controlled Nuclear Fusion Research (IAEA, Vienna, 1971), Vol. 1, p. 495] has never been reproduced. Using a representation of the angular momentum flux based on the solution of an adjoint equation to the usual linearized drift kinetic equation, and performing systematically a large-aspect-ratio expansion, we have obtained the flux for flux surfaces of arbitrary shape. We have found the same analytic form for the temperature gradient driven part of the flux, but the overall numerical multiplier is different and has the opposite sign. Implications for rotations in discharges with no apparent momentum input will be discussed.

  4. Methane Fluxes from Subtropical Wetlands

    NASA Astrophysics Data System (ADS)

    DeLucia, N.; Gomez-Casanovas, N.; Bernacchi, C.

    2013-12-01

    It is well documented that green house gas concentrations have risen at unequivocal rates since the industrial revolution but the disparity between anthropogenic sources and natural sources is uncertain. Wetlands are one example of a natural ecosystem that can be a substantial source or sink for methane (CH4) depending on climate conditions. Due to strict anaerobic conditions required for CH4-generating microorganisms, natural wetlands are one of the main sources for biogenic CH4. Although wetlands occupy less than 5% of total land surface area, they contribute approximately 20% of total CH4 emissions to the atmosphere. The processes regulating CH4 emissions are sensitive to land use and management practices of areas surrounding wetlands. Variation in adjacent vegetation or grazing intensity by livestock can, for example, alter CH4 fluxes from wetland soils by altering nutrient balance, carbon inputs and hydrology. Therefore, understanding how these changes will affect wetland source strength is essential to understand the impact of wetland management practices on the global climate system. In this study we quantify wetland methane fluxes from subtropical wetlands on a working cattle ranch in central Florida near Okeechobee Lake (27o10'52.04'N, 81o21'8.56'W). To determine differences in CH4 fluxes associated with land use and management, a replicated (n = 4) full factorial experiment was designed for wetlands where the surrounding vegetation was (1) grazed or un-grazed and (2) composed of native vegetation or improved pasture. Net exchange of CH4 and CO2 between the land surface and the atmosphere were sampled with a LICOR Li-7700 open path CH4 analyzer and Li-7500A open path CO2/H20 analyzer mounted in a 1-m3 static gas-exchange chamber. Our results showed and verified that CH4 emissions from subtropical wetlands were larger when high soil moisture was coupled with high temperatures. The presence of cattle only amplified these results. These results help quantify

  5. Atmospheric lepton fluxes

    NASA Astrophysics Data System (ADS)

    Gaisser, Thomas K.

    2015-08-01

    This review of atmospheric muons and neutrinos emphasizes the high energy range relevant for backgrounds to high-energy neutrinos of astrophysical origin. After a brief historical introduction, the main distinguishing features of atmospheric νμ and νe are discussed, along with the implications of the muon charge ratio for the νµ / ν̅µ ratio. Methods to account for effects of the knee in the primary cosmic-ray spectrum and the energy-dependence of hadronic interactions on the neutrino fluxes are discussed and illustrated in the context of recent results from IceCube. A simple numerical/analytic method is proposed for systematic investigation of uncertainties in neutrino fluxes arising from uncertainties in the primary cosmic-ray spectrum/composition and hadronic interactions.

  6. Asymptotic domination of cold relativistic MHD winds by kinetic energy flux

    NASA Technical Reports Server (NTRS)

    Begelman, Mitchell C.; Li, Zhi-Yun

    1994-01-01

    We study the conditions which lead to the conversion of most Poynting flux into kinetic energy flux in cold, relativistic hydromagnetic winds. It is shown that plasma acceleration along a precisely radial flow is extremely inefficient due to the near cancellation of the toroidal magnetic pressure and tension forces. However, if the flux tubes in a flow diverge even slightly faster than radially, the fast magnetosonic point moves inward from infinity to a few times the light cylinder radius. Once the flow becomes supermagnetosonic, further divergence of the flux tubes beyond the fast point can accelerate the flow via the 'magnetic nozzle' effect, thereby further converting Poynting flux to kinetic energy flux. We show that the Grad-Shafranov equation admits a generic family of kinetic energy-dominated asymptotic wind solutions with finite total magnetic flux. The Poynting flux in these solutions vanishes logarithmically with distance. The way in which the flux surfaces are nested within the flow depends only on the ratio of angular velocity to poliodal 4-velocity as a function of magnetic flux. Radial variations in flow structure can be expressed in terms of a pressure boundary condition on the outermost flux surface, provided that no external toriodal field surrounds the flow. For a special case, we show explicitly how the flux surfaces merge gradually to their asymptotes. For flows confined by an external medium of pressure decreasing to zero at infinity we show that, depending on how fast the ambient pressure declines, the final flow state could be either a collimated jet or a wind that fills the entire space. We discuss the astrophysical implications of our results for jets from active galactic nuclei and for free pulsar winds such as that believed to power the Crab Nebula.

  7. Heat flux boundary anomalies and thermal winds

    NASA Astrophysics Data System (ADS)

    Dietrich, Wieland; Wicht, Johannes

    2013-04-01

    Several studies have shown strong effects of outer boundary heat flux patterns on the dynamo mechanism in planets. For example, the hemispherical field of the ancient Martian dynamo can be explained by a large scale sinusoidal anomaly of the core mantle boundary heat flux triggered by large scale mantle convection or giant impacts. The magnetic fields show typically the desired effect - though dynamo action is locally stronger where the underneath heat flux is higher. However, it remains an open question if these effects still apply for more realistic planetary parameters, such as vigor of the convection (Rayleigh number) or the rotation rate (Ekman). The sinusoidal variation of the CMB heat flux along the colatitude with larger heat flux in the southern and smaller in the northern hemisphere as used for Mars can lead to a concentration of magnetic field in the south. The shape of such a hemispherical dynamo matches the crustal magnetization pattern at the surface and seems therefore an admissible mode for the ancient Martian dynamo. As the consequence of the emerging latitudinal temperature gradients convection and induction are dominated by thermal winds. These zonal flows were found to be equatorial antisymmetric, axisymmetric, ageostrophic, of strong amplitude and have therefore a severe effect on core convection and especially the induction process. We measure the underlying thermal anomalies as a function of Rayleigh and Ekman number and show that they are responsible for the thermal winds. Our results suggest that temperature anomalies decrease clearly with the supercriticality of the convection due to faster stirring and mixing, but show no additional dependence on the Ekman number. Interestingly, the decline of the latitudinal temperature anomaly follows a recently suggested scaling law for the thickness of thermal boundary layers. Even though the convective supercriticality of planetary cores is rather large and therefore only a minor effect of thermal

  8. Effects of Surface Sensible Heat Fluxes on the Tropical Cyclone Intensity

    NASA Astrophysics Data System (ADS)

    Ma, Zhanhong; Fei, Jianfang

    2016-04-01

    The contributions of surface sensible heat fluxes (SHX) to the evolution of tropical cyclone (TC) intensity and structure are examined in this study by conducting cloud-resolving simulations. Results suggest that although the peak values of SHX could account for nearly 30% of those of the total surface latent and sensible heat fluxes, the impact of SHX on TC intensification is nonetheless not distinct. However, the TC size shows great sensitivity to the SHX that the storm is shrunk by over 20% after removing the SHX. The reduced total surface enthalpy fluxes due to the removal of SHX do not necessarily result in weakened TCs, while the larger surface latent heat fluxes (LHX) basically correspond to stronger TCs. This suggests that the TC intensity is largely dependent on the LHX rather than the total surface enthalpy fluxes, although the latter is generally dominated by the former.

  9. Demonstration of HNO3 Eddy Flux Measurements at the Boulder Atmospheric Observatory Using Active Passivation

    NASA Astrophysics Data System (ADS)

    Roscioli, J. R.; Herndon, S. C.; Zahniser, M. S.; Nelson, D. D.; Zaragoza, J.; Pollack, I. B.; Fischer, E. V.

    2015-12-01

    Eddy flux measurements of "sticky" molecules have historically proven difficult due to strong interactions with instrument surfaces. A novel approach has been developed to improve these response times, enabling flux measurements of nitric acid (HNO3) and and ammonia (NH3). Deliberate addition of the vapor of perfluorinated acids and bases into a sample stream serves to eject existing surface-bound sample molecules and passivate instrument surfaces. HNO3 response times for an Aerodyne quantum cascade laser absorption spectrometer (QCLAS) improve by a factor of 60-fold when actively passivating. This approach was used during field measurements of HNO3 fluxes at the Boulder Atmospheric Observatory, where an actively passivated inertial inlet at 8 m height yielded HNO3 deposition fluxes of 0.5 - 2 nmol/m2/sec. The dependence of the deposition flux upon urban vs rural outflow is discussed.

  10. Flux Sampling Errors for Aircraft and Towers

    NASA Technical Reports Server (NTRS)

    Mahrt, Larry

    1998-01-01

    Various errors and influences leading to differences between tower- and aircraft-measured fluxes are surveyed. This survey is motivated by reports in the literature that aircraft fluxes are sometimes smaller than tower-measured fluxes. Both tower and aircraft flux errors are larger with surface heterogeneity due to several independent effects. Surface heterogeneity may cause tower flux errors to increase with decreasing wind speed. Techniques to assess flux sampling error are reviewed. Such error estimates suffer various degrees of inapplicability in real geophysical time series due to nonstationarity of tower time series (or inhomogeneity of aircraft data). A new measure for nonstationarity is developed that eliminates assumptions on the form of the nonstationarity inherent in previous methods. When this nonstationarity measure becomes large, the surface energy imbalance increases sharply. Finally, strategies for obtaining adequate flux sampling using repeated aircraft passes and grid patterns are outlined.