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Sample records for des emetteurs alpha

  1. Radiosensibilité comparative des cellules épithéliales de trachée de rats après irradiation alpha in vitro

    NASA Astrophysics Data System (ADS)

    Kugel, C.; Bailly-Despiney, I.; Lagroye, I.; Poncy, J. L.

    1998-04-01

    The main risk in nuclear industry is the internal contamination after inhalation of high LET alpha emitters radionuclides. Main targets of pulmonary carcinogenesis are epithelial respiratory tract cells. An in vitro study was performed in order to determine if a difference in the radiosensitivity occured in epithelial cells from the trachea of two rat strains: Sprague Dawley and Wistar Furth-Fischer F344 after alpha exposure. The cells were irradiated after sedimentation in a specific well. The irradiation was performed using 241Am electrodeposited sources. The irradiation dosecloning efficiency relation was evaluated. A kinetic study of the proliferation and the clonal growth has also been investigated. La contamination interne par inhalation de radionucléides émetteurs alpha de haut TEL est le risque majeur de l'industrie nucléaire. Les cibles principales de la cancérogenèse pulmonaire sont les cellules épithéliales de l'appareil respiratoire. Une étude in vitro a été menée pour déterminer s'il existe une différence de radiosensibilité aux rayonnement alpha, des cellules épithéliales trachéales de deux souches de rats : Sprague Dawley et Wistar Furth-Fischer F344. Les cellules sont irradiées sédimentées au fond d'un puit spécifique à l'aide de sources électrodéposées de 241Am. L'évaluation de la survie cellulaire en fonction de la dose d'irradiation est complétée par un suivi cinétique de la formation et de la prolifération des colonies.

  2. Modelisation microstructurale en fatigue/fluage a froid des alliages de titane quasi alpha par le modele des automates cellulaires

    NASA Astrophysics Data System (ADS)

    Boutana, Mohammed Nabil

    Les proprietes d'emploi des alliages de titane sont extremement dependantes a certains aspects des microstructures developpees lors de leur elaboration. Ces microstructures peuvent etre fortement heterogenes du point de vue de leur orientation cristallographique et de leur repartition spatiale. Leurs influences sur le comportement du materiau et son endommagement precoce sont des questions qui sont actuellement soulevees. Dans le present projet de doctorat on chercher a repondre a cette question mais aussi de presenter des solutions tangibles quant a l'utilisation securitaire de ces alliages. Un nouveau modele appele automate cellulaire a ete developpe pour simuler le comportement mecanique des alliages de titane en fatigue-fluage a froid. Ces modeles ont permet de mieux comprendre la correlation entre la microstructure et le comportement mecanique du materiau et surtout une analyse detaillee du comportement local du materiau. Mots-cles: Automate cellulaire, fatigue/fluage, alliage de titane, inclusion d'Eshelby, modelisation

  3. Des-gamma-carboxy Prothrombin and Alpha fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma

    PubMed Central

    Lok, Anna S.; Sterling, Richard K.; Everhart, James E.; Wright, Elizabeth C.; Hoefs, John C.; Di Bisceglie, Adrian M.; Morgan, Timothy R.; Kim, Hae-Young; Lee, William M.; Bonkovsky, Herbert L.; Dienstag, Jules L.

    2009-01-01

    Background and Aims: The outcome of patients with hepatocellular carcinoma (HCC) remains poor because of late diagnosis. The aim of this study was to compare the accuracy of alpha fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) in the early diagnosis of HCC. Methods: Among 1031 patients randomized in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) Trial, a nested case-control study of 39 HCC cases (24 early stage) and 77 matched controls was conducted to compare the performance of AFP and DCP. Testing was performed on sera from 12 months prior (month ?12) to the time of HCC diagnosis (month 0). Results: The sensitivity and specificity of DCP at month 0 was 74% and 86% at a cutoff of 40 mAU/mL and 43% and 100% at a cutoff of 150 mAU/mL. The sensitivity and specificity of AFP at month 0 was 61% and 81% at a cutoff of 20 ng/mL and 22% and 100% at a cutoff of 200 ng/mL. At month ?12, the sensitivity and specificity at the low cutoff was 43% and 94% for DCP and 47% and 75% for AFP. Combining both markers increased the sensitivity to 91% at month 0 and 73% at month 12 but the specificity decreased to 74% and 71%. Diagnosis of early HCC was triggered by surveillance ultrasound in 14, doubling of AFP in 5 and combination of tests in 5 patients. Conclusions: Biomarkers are needed to complement ultrasound in the detection of early HCC but neither DCP nor AFP is optimal. PMID:19852963

  4. Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

    PubMed Central

    Shakado, Satoshi; Sakisaka, Shotaro; Chayama, Kazuaki; Okanoue, Takeshi; Toyoda, Joji; Izumi, Namiki; Matsumoto, Akihiro; Takehara, Tetsuo; Ido, Akio; Hiasa, Yoichi; Yoshioka, Kentaro; Nomura, Hideyuki; Ueno, Yoshiyuki; Seike, Masataka; Kumada, Hiromitsu

    2015-01-01

    AIM: To investigate risk factors for development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus-related liver cirrhosis (LC-C). METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon (IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging. RESULTS: HCC was diagnosis in 50 (21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older (P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein (AFP) (P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio (OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ? 10 ng/mL (P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-?-carboxy prothrombin (DCP) levels of ? 40 mAU/mL at 24 wk after the completion of IFN and ribavirin therapy (P < 0.001, OR = 24.43, 95%CI: 4.11-238.67). CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. PMID:26644819

  5. Sur la nature des absorbeurs dans l'interpretation transactionnelle de la mecanique quantique

    NASA Astrophysics Data System (ADS)

    Boisvert, Jean-Sebastien

    L'interpretation transactionnelle de la mecanique quantique est l'une des plus recentes propositions de description des phenomenes du microcosme. En accord avec les predictions de la mecanique quantique standard, l'interpretation transactionnelle propose une alternative a celle de Copenhague. Son principal avantage est qu'elle permet de visualiser les mecanismes sous-jacents a l'echange d'energie, de quantite de mouvement ou d'autres quantites quantiques entre un emetteur et un absorbeur. Ces echanges sont le resultat, a l'instar de la theorie de l'absorbeur de Wheeler et Feynman, de l'utilisation autant d'ondes avancees que retardees. Bien que l'interpretation transactionnelle n'ait pas attire la plus grande attention scientifique, plusieurs critiques lui ont ete adressees. Dans les annees 1990, differentes experiences a mesure sans interaction ont ete concues. Depuis, il a ete avance que la version originale de l'interpretation transactionnelle pouvait difficilement rendre compte de ce type d'experience et meme qu'elle n'est pas compatible avec le concept d'univers quadridimensionnel. La recherche de ce memoire par article consiste a montrer que lorsque l'on utilise systematiquement l'interpretation transactionnelle en considerant la configuration totale des absorbeurs (incluant l'absorbeur universel), il n'est pas necessaire de faire appel a une hierarchie de transactions comme certains l'ont propose.

  6. Etude des phenomenes dynamiques ultrarapides et des caracteristiques impulsionnelles d'emission terahertz du supraconducteur YBCO

    NASA Astrophysics Data System (ADS)

    Savard, Stephane

    Les premieres etudes d'antennes a base de supraconducteurs a haute temperature critique emettant une impulsion electromagnetique dont le contenu en frequence se situe dans le domaine terahertz remontent a 1996. Une antenne supraconductrice est formee d'un micro-pont d'une couche mince supraconductrice sur lequel un courant continu est applique. Un faisceau laser dans le visible est focalise sur le micro-pont et place le supraconducteur dans un etat hors-equilibre ou des paires sont brisees. Grace a la relaxation des quasiparticules en surplus et eventuellement de la reformation des paires supraconductrices, nous pouvons etudier la nature de la supraconductivite. L'analyse de la cinetique temporelle du champ electromagnetique emis par une telle antenne terahertz supraconductrice s'est averee utile pour decrire qualitativement les caracteristiques de celle-ci en fonction des parametres d'operation tels que le courant applique, la temperature et la puissance d'excitation. La comprehension de l'etat hors-equilibre est la cle pour comprendre le fonctionnement des antennes terahertz supraconductrices a haute temperature critique. Dans le but de comprendre ultimement cet etat hors-equilibre, nous avions besoin d'une methode et d'un modele pour extraire de facon plus systematique les proprietes intrinseques du materiau qui compose l'antenne terahertz a partir des caracteristiques d'emission de celle-ci. Nous avons developpe une procedure pour calibrer le spectrometre dans le domaine temporel en utilisant des antennes terahertz de GaAs bombarde aux protons H+ comme emetteur et detecteur. Une fois le montage calibre, nous y avons insere une antenne emettrice dipolaire de YBa 2Cu3O7-delta . Un modele avec des fonctions exponentielles de montee et de descente du signal est utilise pour lisser le spectre du champ electromagnetique de l'antenne de YBa 2Cu3O7-delta, ce qui nous permet d'extraire les proprietes intrinseques de ce dernier. Pour confirmer la validite du modele choisi, nous avons mesure les proprietes intrinseques du meme echantillon de YBa2Cu3O7- delta avec la technique pompe-visible et sonde-terahertz donnant, elle aussi, acces aux temps caracteristiques regissant l'evolution hors-equilibre de ce materiau. Dans le meilleur scenario, ces temps caracteristiques devraient correspondre a ceux evalues grace a la modelisation des antennes. Un bon controle des parametres de croissance des couches minces supraconductrices et de fabrication du dispositif nous a permis de realiser des antennes d'emission terahertz possedant d'excellentes caracteristiques en terme de largeur de bande d'emission (typiquement 3 THz) exploitables pour des applications de spectroscopie resolue dans le domaine temporel. Le modele developpe et retenu pour le lissage du spectre terahertz decrit bien les caracteristiques de l'antenne supraconductrice pour tous les parametres d'operation. Toutefois, le lien avec la technique pompe-sonde lors de la comparaison des proprietes intrinseques n'est pas direct malgre que les deux techniques montrent que le temps de relaxation des porteurs augmente pres de la temperature critique. Les donnees en pompe-sonde indiquent que la mesure du temps de relaxation depend de la frequence de la sonde, ce qui complique la correspondance des proprietes intrinseques entre les deux techniques. De meme, le temps de relaxation extrait a partir du spectre de l'antenne terahertz augmente en s'approchant de la temperature critique (T c) de YBa2Cu 3O7-delta. Le comportement en temperature du temps de relaxation correspond a une loi de puissance qui est fonction de l'inverse du gap supraconducteur avec un exposant 5 soit 1/Delta 5(T). Le travail presente dans cette these permet de mieux decrire les caracteristiques des antennes supraconductrices a haute temperature critique et de les relier aux proprietes intrinseques du materiau qui les compose. De plus, cette these presente les parametres a ajuster comme le courant applique, la puissance de la pompe, la temperature d'operation, etc, afin d'optimiser l'emission et les performances de ces

  7. Alpha Particle

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Term that is sometimes used to describe a helium nucleus, a positively charged particle that consists of two protons and two neutrons, bound together. Alpha particles, which were discovered by Ernest Rutherford (1871-1937) in 1898, are emitted by atomic nuclei that are undergoing alpha radioactivity. During this process, an unstable heavy nucleus spontaneously emits an alpha particle and transmut...

  8. Alpha Thalassemia

    MedlinePLUS

    ... an apparently normal individual has a child with hemoglobin H disease or alpha thalassemia minor. It can ... gene on one chromosome 25% 25% 25% 25% hemoglobin H disease there is a 25% chance with ...

  9. Alpha-1 Antitrypsin Deficiency

    MedlinePLUS

    ... Liver > Liver Disease Information > Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Explore this section to learn more about alpha-1 antitrypsin deficiency, including a description of the ...

  10. Des Moines.

    ERIC Educational Resources Information Center

    Gore, Deborah, Ed.

    1988-01-01

    This document, intended for elementary students, contains articles and activities designed to acquaint young people with the history of Des Moines, Iowa. The articles are short, and new or difficult words are highlighted and defined for young readers. "The Raccoon River Indian Agency" discusses the archeological exploration of the indian…

  11. Service des immeubles Service des Immeubles

    E-print Network

    Laval, Université

    les gaz ayant un effet de serre, trois des six gaz pris en compte par le protocole de Kyoto, soit le travail employés dans la réalisation du bilan des GES est basé sur les références suivantes : GHG Protocol

  12. Alpha College Today.

    ERIC Educational Resources Information Center

    Leppert, William A.

    1979-01-01

    Presents a follow-up report on Alpha, an experimental unit of the College of DuPage in Illinois. Traces the postgraduation activities of Alpha graduates and describes new Alpha programs and projects. (CAM)

  13. Special Space Curves Characterized by det({\\alpha}^{(3)}, {\\alpha}^{(4)},{\\alpha}^{(5)})=0

    E-print Network

    Yayali, Yusuf

    2012-01-01

    In this study, by using the facts that det({\\alpha}^{(1)}, {\\alpha}^{(2)}, {\\alpha}^{(3)}) = 0 characterizes plane curve, and det({\\alpha}^{(2)}, {\\alpha}^{(3)}, {\\alpha}^{(4)}) = 0 does a curve of constant slope, we give the special space curves that are characterized by det({\\alpha}^{(3)}, {\\alpha}^{(4)}, {\\alpha}^{(5)}) = 0, in different approaches. We find that the space curve is Salkowski if and only if det({\\alpha}^{(3)}, {\\alpha}^{(4)}, {\\alpha}^{(5)}) = 0. The approach we used in this paper is useful in understanding the role of the curves that are characterized by det({\\alpha}^{(3)}, {\\alpha}^{(4)}, {\\alpha}^{(5)})=0 in differential geometry.

  14. Clinical utility of simultaneous measurement of alpha-fetoprotein and des-?-carboxy prothrombin for diagnosis of patients with hepatocellular carcinoma in China: A multi-center case-controlled study of 1,153 subjects.

    PubMed

    Song, Peipei; Feng, Xiaobin; Inagaki, Yoshinori; Song, Tianqiang; Zhang, Keming; Wang, Zhigang; Zheng, Shuguo; Ma, Kuansheng; Li, Qiang; Kong, Dalu; Wu, Qiang; Zhang, Ti; Zhao, Xin; Hasegawa, Kiyoshi; Sugawara, Yasuhiko; Kokudo, Norihiro; Tang, Wei

    2014-10-01

    This study aimed to investigate the clinical utility of simultaneous measurement of alphafetoprotein (AFP) and des-?-carboxy prothrombin (DCP) for hepatocellular carcinoma (HCC) diagnosis in Chinese patients predominantly caused by hepatitis B virus infection by a multi-center case-controlled study. Subjects were 1,153 individuals from three major hospitals in China, including 550 cases in HCC group, 164 in Malignant disease group, 182 in Benign disease group, 85 in Chronic liver disease group, and 173 in Normal group. Serum levels of AFP and DCP were measured and clinicopathological features were determined for all subjects. Results showed that the levels of DCP and AFP were significantly higher in HCC group (550 patients, 74.18% with HBV infection) than that in other four groups (P < 0.001). Receiver operating curves (ROC) indicated the optimal cut-off value was 86 mAU/mL for DCP with a sensitivity of 71.50% and specificity of 86.30%, and 21 ng/mL for AFP with a sensitivity of 68.00% and specificity of 93.20%. The area under ROC curve was 0.846 for DCP, 0.832 for AFP, and 0.890 for the combination of DCP and AFP. The combination of DCP and AFP resulted in a higher Youden index and a sensitivity of approximately 90%, even for small tumors. The simultaneous measurement of AFP and DCP could achieve a better sensitivity in diagnosing Chinese HCC patients, even for small tumors. PMID:25382443

  15. Diethylstilbestrol (DES) and Cancer

    MedlinePLUS

    ... products that contained DES. DES Product Names Nonsteroidal Estrogens Benzestrol Chlorotrianisene Comestrol Cyren A. Cyren B. Delvinal ... Stils Synestrin Synestrol Synthosestrin Tace Vallestril Willestrol Nonsteroidal Estrogen-Androgen Combinations Amperone Di-Erone Estan Metystil Teserene ...

  16. Ab initio alpha-alpha scattering

    E-print Network

    Serdar Elhatisari; Dean Lee; Gautam Rupak; Evgeny Epelbaum; Hermann Krebs; Timo A. Lähde; Thomas Luu; Ulf-G. Meißner

    2015-06-11

    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  17. DES RESSOURCES RENOUVELABLES

    E-print Network

    Laval, Université

    DES SCIENCES DE L'AGRICULTURE ET DE L'ALIMENTATION Vice-décanat à la recherche Pavillon Paul LA FSAA La Faculté des sciences de l'agriculture et de l'alimentation (FSAA) permet d'accéder à l plantes, contribuent à la réduction du diabète et des maladies cardiovasculaires par l'alimentation

  18. Direction des Relations Internationales

    E-print Network

    Debarre, Olivier

    Direction des Relations Internationales ERASMUS : liste des accords par pays Les candidatures Philosophie des Sciences 15/06 15/12 COLOGNE Universität zu Köln Littérature et linguistique 15/06 15/12 WÜRZBOURG Université J. Maximilians Littérature et Linguistique 15/06 15/01 AUTRICHE VIENNE Université de

  19. Tau Decays and $\\alpha_s$

    E-print Network

    Zhang, Zhiqing

    2014-01-01

    The evolution of the determination of the strong coupling constant $\\alpha_s$ from the leptonic branching ratios, the lifetime, and the invariant mass distributions of the hadronic final state of the $\\tau$ lepton over the last two decades is briefly reviewed. The improvements in the latest ALEPH update are described in some detail. Currently this is one of the most precise $\\alpha_s$ determinations. Together with the other determination at the $Z$ boson mass pole, they constitutes the most accurate test of the asymptotic freedom in QCD.

  20. Ab initio alpha-alpha scattering.

    PubMed

    Elhatisari, Serdar; Lee, Dean; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G

    2015-12-01

    Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning stages. It also substantially affects models of thermonuclear type Ia supernovae, owing to carbon detonation in accreting carbon-oxygen white-dwarf stars. In these reactions, the accurate calculation of the elastic scattering of alpha particles and alpha-like nuclei--nuclei with even and equal numbers of protons and neutrons--is important for understanding background and resonant scattering contributions. First-principles calculations of processes involving alpha particles and alpha-like nuclei have so far been impractical, owing to the exponential growth of the number of computational operations with the number of particles. Here we describe an ab initio calculation of alpha-alpha scattering that uses lattice Monte Carlo simulations. We use lattice effective field theory to describe the low-energy interactions of protons and neutrons, and apply a technique called the 'adiabatic projection method' to reduce the eight-body system to a two-cluster system. We take advantage of the computational efficiency and the more favourable scaling with system size of auxiliary-field Monte Carlo simulations to compute an ab initio effective Hamiltonian for the two clusters. We find promising agreement between lattice results and experimental phase shifts for s-wave and d-wave scattering. The approximately quadratic scaling of computational operations with particle number suggests that it should be possible to compute alpha scattering and capture on carbon and oxygen in the near future. The methods described here can be applied to ultracold atomic few-body systems as well as to hadronic systems using lattice quantum chromodynamics to describe the interactions of quarks and gluons. PMID:26632590

  1. alpha-Hexachlorocyclohexane (alpha-HCH)

    Integrated Risk Information System (IRIS)

    alpha - Hexachlorocyclohexane ( alpha - HCH ) ; CASRN 319 - 84 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Ass

  2. Alpha One Foundation

    MedlinePLUS

    ... distance of more than 17 miles in his Virtual Walk. Read More Alpha completes 17-mile Virtual Walk More than 240 CSL Behring employees in Illinois participated in the Virtual Walk for Alpha-1. Read More More than ...

  3. Dynamic Ly alpha jets

    E-print Network

    J. Koza; R. J. Rutten; A. Vourlidas

    2009-03-24

    The solar chromosphere and transition region are highly structured and complex regimes. A recent breakthrough has been the identification of dynamic fibrils observed in H alpha as caused by field-aligned magnetoacoustic shocks. We seek to find whether such dynamic fibrils are also observed in Ly alpha. We used a brief sequence of four high-resolution Ly alpha images of the solar limb taken by the Very high Angular resolution ULtraviolet Telescope (VAULT), which displays many extending and retracting Ly alpha jets. We measured their top trajectories and fitted parabolas to the 30 best-defined ones. Most jet tops move supersonically. Half of them decelerate, sometimes superballistically, the others accelerate. This bifurcation may arise from incomplete sampling of recurrent jets. The similarities between dynamic Ly alpha jets and H alpha fibrils suggest that the magnetoacoustic shocks causing dynamic H alpha fibrils also affect dynamic Ly alpha jets.

  4. The Alpha Centauri System.

    ERIC Educational Resources Information Center

    Soderblom, David R.

    1987-01-01

    Describes the Alpha Centauri star system, which is the closest star system to the sun. Discusses the difficulties associated with measurements involving Alpha Centauri, along with some of the recent advances in stellar seismology. Raises questions about the possibilities of planets around Alpha Centauri. (TW)

  5. Profil des candidats : Master de Biologie ou Biologie des Systmes

    E-print Network

    Radulescu, Ovidiu

    Profil des candidats : Master de Biologie ou Biologie des Systèmes Candidatures en ligne : sur le approche de biologie des systèmes du contrôle de l'entrée et de la sortie mitotiques chez les eucaryotes

  6. Médecine des voyages

    PubMed Central

    Aw, Brian; Boraston, Suni; Botten, David; Cherniwchan, Darin; Fazal, Hyder; Kelton, Timothy; Libman, Michael; Saldanha, Colin; Scappatura, Philip; Stowe, Brian

    2014-01-01

    Résumé Objectif Définir la pratique de la médecine des voyages, présenter les éléments fondamentaux d’une consultation complète préalable aux voyages à des voyageurs internationaux et aider à identifier les patients qu’il vaudrait mieux envoyer en consultation auprès de professionnels de la médecine des voyages. Sources des données Les lignes directrices et les recommandations sur la médecine des voyages et les maladies liées aux voyages publiées par les autorités sanitaires nationales et internationales ont fait l’objet d’un examen. Une recension des ouvrages connexes dans MEDLINE et EMBASE a aussi été effectuée. Message principal La médecine des voyages est une spécialité très dynamique qui se concentre sur les soins préventifs avant un voyage. Une évaluation exhaustive du risque pour chaque voyageur est essentielle pour mesurer avec exactitude les risques particuliers au voyageur, à son itinéraire et à sa destination et pour offrir des conseils sur les interventions les plus appropriées en gestion du risque afin de promouvoir la santé et prévenir les problèmes médicaux indésirables durant le voyage. Des vaccins peuvent aussi être nécessaires et doivent être personnalisés en fonction des antécédents d’immunisation du voyageur, de son itinéraire et du temps qu’il reste avant son départ. Conclusion La santé et la sécurité d’un voyageur dépendent du degré d’expertise du médecin qui offre le counseling préalable à son voyage et les vaccins, au besoin. On recommande à ceux qui donnent des conseils aux voyageurs d’être conscients de l’ampleur de cette responsabilité et de demander si possible une consultation auprès de professionnels de la médecine des voyages pour tous les voyageurs à risque élevé.

  7. RPERTOIRE DES PROJETS DE LA

    E-print Network

    .................................................................................. 57 Département des sciences animales Élaboration, mise à l'essai et implantation de mesure de la qualité des services de soutien Contrat

  8. Portail des maths & PLM 2.0 Jacquelin Charbonnel -Journes des DU -Paris, 11 avril 2013 Portail des maths

    E-print Network

    Menichi, Luc

    Portail des maths & PLM 2.0 Jacquelin Charbonnel - Journées des DU - Paris, 11 avril 2013 Portail des maths et PLM 2.0 Jacquelin Charbonnel - Mathrice Journées des DU - Paris, 11 avril 2013 #12;Portail des maths & PLM 2.0 Jacquelin Charbonnel - Journées des DU - Paris, 11 avril 2013 Portail des

  9. Jahresbericht des Hochschulrates

    E-print Network

    Ferrari, Patrik L.

    1 Jahresbericht 2014 des Hochschulrates der Rheinischen Friedrich-Wilhelm-Universität Bonn #12;2 I Engels als Vorsitzender. Am 15. Juli 2014 wurde Prof. Dr. E. Jürgen Zöllner, auf Vorschlag des. Helmut Schwarz, Dr. Katrin Vernau und Prof. Dr. Dieter Engels, der zum Vorsitzenden dieser Kommission

  10. Direction des Ressources Humaines Bureau du recrutement et des

    E-print Network

    Wolf, Christian

    2015 Contact Direction des Ressources Humaines Bureau du recrutement et des concours Bâtiment Julie Maîtriser au moins une méthode de spécification et de conception . Maîtriser des méthodes et techniques de langages Objet (C++, Java), Web (PHP), SQL, script... . Avoir des compétences en programmation web et dans

  11. Des Moines and Raccoon Rivers, Des Moines, Iowa

    E-print Network

    US Army Corps of Engineers

    Des Moines and Raccoon Rivers, Des Moines, Iowa 18 October 2006 Abstract: The recommended plan opportunities along the Des Moines and Raccoon Rivers in the areas of Birdland Park, Central Place and downtown Additional Information: Mississippi Valley Division Rock Island District Des Moines and Raccoon River Damage

  12. Les bonhommes-foumis Il y a des annes, bien des saisons et bien des jours, vivaient des petits

    E-print Network

    van Tiggelen, Bart

    Les bonhommes-foumis Il y a des années, bien des saisons et bien des jours, vivaient des petits petites colonies sur leur territoire principal ou en territoire éloigné. Un jour, elles se sont retrouvées sur un petit territoire charmant du nom de Cargèse. Les petits bonhommes-fourmis se sont retrouvés

  13. Alpha-particle diagnostics

    SciTech Connect

    Young, K.M.

    1991-01-01

    This paper will focus on the state of development of diagnostics which are expected to provide the information needed for {alpha}- physics studies in the future. Conventional measurement of detailed temporal and spatial profiles of background plasma properties in DT will be essential for such aspects as determining heating effectiveness, shaping of the plasma profiles and effects of MHD, but will not be addressed here. This paper will address (1) the measurement of the neutron source, and hence {alpha}-particle birth profile, (2) measurement of the escaping {alpha}-particles and (3) measurement of the confined {alpha}-particles over their full energy range. There will also be a brief discussion of (4) the concerns about instabilities being generated by {alpha}-particles and the methods necessary for measuring these effects. 51 refs., 10 figs.

  14. Imaging alpha particle detector

    DOEpatents

    Anderson, D.F.

    1980-10-29

    A method and apparatus for detecting and imaging alpha particles sources is described. A dielectric coated high voltage electrode and a tungsten wire grid constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source to be quantitatively or qualitatively analyzed. A thin polyester film window allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  15. Event counting alpha detector

    DOEpatents

    Bolton, Richard D. (Los Alamos, NM); MacArthur, Duncan W. (Los Alamos, NM)

    1996-01-01

    An electrostatic detector for atmospheric radon or other weak sources of alpha radiation. In one embodiment, nested enclosures are insulated from one another, open at the top, and have a high voltage pin inside and insulated from the inside enclosure. An electric field is produced between the pin and the inside enclosure. Air ions produced by collision with alpha particles inside the decay volume defined by the inside enclosure are attracted to the pin and the inner enclosure. With low alpha concentrations, individual alpha events can be measured to indicate the presence of radon or other alpha radiation. In another embodiment, an electrical field is produced between parallel plates which are insulated from a single decay cavity enclosure.

  16. Imaging alpha particle detector

    DOEpatents

    Anderson, David F. (Los Alamos, NM)

    1985-01-01

    A method and apparatus for detecting and imaging alpha particles sources is described. A conducting coated high voltage electrode (1) and a tungsten wire grid (2) constitute a diode configuration discharge generator for electrons dislodged from atoms or molecules located in between these electrodes when struck by alpha particles from a source (3) to be quantitatively or qualitatively analyzed. A thin polyester film window (4) allows the alpha particles to pass into the gas enclosure and the combination of the glass electrode, grid and window is light transparent such that the details of the source which is imaged with high resolution and sensitivity by the sparks produced can be observed visually as well. The source can be viewed directly, electronically counted or integrated over time using photographic methods. A significant increase in sensitivity over other alpha particle detectors is observed, and the device has very low sensitivity to gamma or beta emissions which might otherwise appear as noise on the alpha particle signal.

  17. Event counting alpha detector

    DOEpatents

    Bolton, R.D.; MacArthur, D.W.

    1996-08-27

    An electrostatic detector is disclosed for atmospheric radon or other weak sources of alpha radiation. In one embodiment, nested enclosures are insulated from one another, open at the top, and have a high voltage pin inside and insulated from the inside enclosure. An electric field is produced between the pin and the inside enclosure. Air ions produced by collision with alpha particles inside the decay volume defined by the inside enclosure are attracted to the pin and the inner enclosure. With low alpha concentrations, individual alpha events can be measured to indicate the presence of radon or other alpha radiation. In another embodiment, an electrical field is produced between parallel plates which are insulated from a single decay cavity enclosure. 6 figs.

  18. VIE DES RESEAUX Exploration pluridisciplinaire des identits

    E-print Network

    van Tiggelen, Bart

    sous concentration solaire, caractérisée à l'iEs Dans le contexte budgétaire français des prochaines revues LIVRE REVUE PHOTO ©CNRsPhotothèque-FOUCARANAlain,CUMiNALYvan �LAUNEwww.cnrs.fr Cellule solaire

  19. Le Point sur la Pharmacologie des Agents Anesthesiques Chez le Brule Grave

    PubMed Central

    Siah, S.; Ababou, K.; Benziane, H.; El Jaoudi; Bensghir, M.; Bakali, H.; El Wali, A.; Ihrai, I.; Drissi, N.K.

    2008-01-01

    Summary La pharmacologie des agents anesthésiques chez le brûlé est variable et imprévisible. Dans les premières 48 h, il y a une hypovolémie avec chute du débit cardiaque et des fuites plasmatiques. Après 48 h, il y a une hypervolémie avec augmentation du débit cardiaque, hypermétabolisme et la clearance des médicaments est augmentée. Parmi les facteurs de déséquilibre, on retrouve les variations des protéines plasmatiques. Deux protéines sont importantes chez le brûlé grave : l'albumine et l'alpha 1- glycoprotéine. Leur taux varie beaucoup au cours de l'évolution de la brûlure. Les agents anesthésiques dont la liaison avec ces deux protéines est prédominante verront leur pharmacocinétique modifiée. L'anesthésiste-réanimateur du service des brûlés va maîtriser ces notions pharmacologiques pour utiliser à bon escient les agents anesthésiques. PMID:21991108

  20. Facult des arts et des sciences Sciences sociales et psychologie | Cartographie de la recherche 2012 TABLE DES MATIRES

    E-print Network

    Montréal, Université de

    #12;Faculté des arts et des sciences ­ Sciences sociales et psychologie | Cartographie de la ..................................................................................................................................................................... 2 La Faculté des arts et des sciences (FAS), c'est....................................................................................... 3 Sciences sociales et psychologie

  1. Alpha-1 Antitrypsin Test

    MedlinePLUS

    ... to normal patterns. Alpha-1 antitrypsin genotype testing ( DNA testing) can be used to establish which SERPINA1 gene ... type (MM) gene and produce sufficient AAT. When DNA testing indicates the presence of one or two abnormal ...

  2. Alpha Thalassemia (For Parents)

    MedlinePLUS

    ... of alpha thalassemia trait may want to seek genetic counseling if they're considering having children. If your ... for a Seriously Ill Child All About Genetics Genetic Counseling Genetic Testing Blood Sickle Cell Disease Word! Anemia ...

  3. Alpha Hydroxy Acids

    MedlinePLUS

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Cosmetics Home Cosmetics Products & Ingredients Ingredients Alpha Hydroxy Acids ... contains AHAs? Why are AHAs used in some cosmetics? Products containing AHAs are marketed for a variety ...

  4. Alpha Lambda & Officers 

    E-print Network

    Unknown

    2011-08-17

    Fifteen isolates of Streptococcus species including six reference strains of S. agalactiae were obtained and their surface carbohydrates were examined for their galactosyl linkage properties using an anti-alpha galactosyl antibody purified from calf...

  5. Alpha Particle Diagnostic

    SciTech Connect

    Fisher, Ray, K.

    2009-05-13

    The study of burning plasmas is the next frontier in fusion energy research, and will be a major objective of the U.S. fusion program through U.S. collaboration with our international partners on the ITER Project. For DT magnetic fusion to be useful for energy production, it is essential that the energetic alpha particles produced by the fusion reactions be confined long enough to deposit a significant fraction of their initial ~3.5 MeV energy in the plasma before they are lost. Development of diagnostics to study the behavior of energetic confined alpha particles is a very important if not essential part of burning plasma research. Despite the clear need for these measurements, development of diagnostics to study confined the fast confined alphas to date has proven extremely difficult, and the available techniques remain for the most part unproven and with significant uncertainties. Research under this grant had the goal of developing diagnostics of fast confined alphas, primarily based on measurements of the neutron and ion tails resulting from alpha particle knock-on collisions with the plasma deuterium and tritium fuel ions. One of the strengths of this approach is the ability to measure the alphas in the hot plasma core where the interesting ignition physics will occur.

  6. Rpertoire des emplois en dcembre 2011 Des diplms de Master

    E-print Network

    Jeanjean, Louis

    du texte (UFR SLHS) - Sport langage et intervention (UPFR Sports) - Théâtres et cultures du monde administratif et financier (Entreprise) (IAE) - Management des relations humaines (UFR STGI) - Marketing et) - Sociologie et anthropologie des savoirs et des normes (UFR SLHS) - Sports, loisir, développement territorial

  7. Zoom mtierssur Les mtiers desLes mtiers des

    E-print Network

    de la Londe. DIFFUSION, COMMERCIALISATION, MARKETING Directeur du département: Philippe Gille ONISEP VPC, 12 mail Barthélemy Thimonnier, Lognes, 77437 Marne-la-Vallée Cedex 2 Internet: http (allocation des fréquences, gestion des appels), l'internet (concep- tion des protocoles de communication

  8. The DES Story: Lessons Learned

    Cancer.gov

    Dr. Robert Hoover discusses the DES followup study, which follows diethylstilbestrol (DES) exposed and unexposed mothers, daughters and sons, and granddaughters for adverse health effects resulting from this exposure.

  9. La biogenèse des mélanosomes

    PubMed Central

    Delevoye, Cédric; Giordano, Francesca; van Niel, Guillaume; Raposo, Graça

    2012-01-01

    Les mélanocytes situés à la base de l’épiderme produisent des mélanosomes qui sont transférés aux kératinocytes pour assurer la pigmentation de l’épiderme et sa photoprotection contre les rayons ultraviolets. Les mélanosomes, organites apparentés aux lysosomes, sont le lieu de synthèse et de stockage d’un pigment, la mélanine. Leur formation dépend de protéines mélanosomales qui transitent par les voies de biosynthèse et d’endocytose et exploitent les mécanismes moléculaires du trafic intracellulaire. Les acteurs moléculaires impliqués dans le transport des protéines mélanosomales et la biogenèse des mélanosomes sont la cible de mutations dans des maladies génétiques accompagnées d’hypopigmentation comme l’albinisme et les maladies lysosomales. Les études menées sur les mélanocytes issus de souris modèles de ces maladies permettent de comprendre certaines des étapes-clés de la mélanogenèse ainsi que les dysfonctionnements associés à ces pathologies. De plus, décrypter la mélanogenèse facilite également la compréhension d’autres processus physiologiques, comme l’illustrent les similitudes inattendues avec l’amyloïdogenèse dans les maladies neurodégénératives. PMID:21382323

  10. Architecture des ordinateurs I Prsentation

    E-print Network

    Boyer, Michel

    version anglaise o Structured Computer Organization, 5th edition. page 8IFT1227 ­ Architecture des99-06-09 1 IFT1227 Architecture des ordinateurs I Présentation El Mostapha Aboulhamid Em.aboulhamid@umontreal.ca Université de Montréal page 2IFT1227 ­ Architecture des ordinateurs 1 ­ JP DAVID & EM Aboulhamid Plan de

  11. The Apollo Alpha Spectrometer.

    NASA Technical Reports Server (NTRS)

    Jagoda, N.; Kubierschky, K.; Frank, R.; Carroll, J.

    1973-01-01

    Located in the Science Instrument Module of Apollo 15 and 16, the Alpha Particle Spectrometer was designed to detect and measure the energy of alpha particles emitted by the radon isotopes and their daughter products. The spectrometer sensor consisted of an array of totally depleted silicon surface barrier detectors. Biased amplifier and linear gate techniques were utilized to reduce resolution degradation, thereby permitting the use of a single 512 channel PHA. Sensor identification and in-flight radioactive calibration were incorporated to enhance data reduction.

  12. Des Vents et des Jets Astrophysiques

    NASA Astrophysics Data System (ADS)

    Sauty, C.

    Plasma outflows from a central gravitating object are a widespread phenomenon in astrophysics. They include the solar and stellar winds, jets from Young Stellar Objects, jets from compact stellar objects and extra-galactic jets associated with Active Galactic Nuclei and quasars. Beyond this huge zoology, a common theoretical ground exists. The aim of this review is to present qualitatively the various theories of winds (Part 1) and how different astrophysical domains interplay. A more or less complete catalog of the ideas proposed for explaining the acceleration and the morphologies of winds and jets is intended. All this part avoids getting into any mathematical formalism. Some macroscopic properties of such outflows may be described by solving the time-independent and axisymmetric magnetohydrodynamic equations. This formalism, underlying most of the theories, is presented in Part 2. It helps to introduce quantitatively the free integrals that such systems possess. Those integrals play an important role in the basic physics of acceleration and collimation, in particular the mass loss rate, the angular momentum loss rate and the energy of the magnetic rotator. Most of the difficulty in modelling flows lies in the necessity to cross critical points, characteristic of non linear equations. The physical nature and the location of such critical points is debated because they are the clue towards the resolution. We thus introduce the notions of topology and critical points (Parts 3 and 4) from the simplest hydrodynamic and spherically symmetric case to the most sophisticated, MHD and axisymmetric cases. Particular attention is given to self-similar models which allows to give some general and simple ideas on the problem due to their semi-analytical treatment. With the use of these notions, a more quantitative comparison of the various models is given (Parts 3 and 4), especially on the shape of the flows. It is thus shown that magnetic collimation of winds into jets is a well expected result from the theory. Although, collimation may be conical, paraboloidal or cylindrical (Part 4), cylindrical collimation is the more likely to occur. The shape of outflows may then be used as a tool to predict physical conditions on the flows or on their source. L'éjection continue de plasma autour d'objets massifs est un phénomène largement répandu en astrophysique, que ce soit sous la forme du vent solaire, de vents stellaires, de jets d'étoiles en formation, de jets stellaires autour d'objets compacts ou de jets extra-galactiques. Cette zoologie diversifiée fait pourtant l'objet d'un commun effort de modélisation. Le but de cette revue est d'abord de présenter qualitativement le développement, depuis leur origine, des diverses théories de vents (Partie 1) et l'inter disciplinarité dans ce domaine. Il s'agit d'une énumération, plus ou moins exhaustive, des idées proposées pour expliquer l'accélération et la morphologie des vents et des jets, accompagnée d'une présentation sommaire des aspects observationnels. Cette partie s'abstient de tout aspect faisant appel au formalisme mathématique. Ces écoulements peuvent être décrits, au moins partiellement, en résolvant les équations magnétohydrodynamiques, axisymétriques et stationnaires. Ce formalisme, à la base de la plupart des théories, est exposé dans la Partie 2. Il permet d'introduire quantitativement les intégrales premières qu'un tel système possède. Ces dernières sont amenées à jouer un rôle important dans la compréhension des phénomènes d'accélération ou de collimation, en particulier le taux de perte de masse, le taux de perte de moment angulaire ou l'énergie du rotateur magnétique. La difficulté de modélisation réside dans l'existence de points critiques, propres aux équations non linéaires, qu'il faut franchir. La nature physique et la localisation de ces points critiques fait l'objet d'un débat important car ils sont la clef de voute de la résolution. Nous introduisons donc la notion de topologie des points critiques (Parties 3 et 4

  13. [alpha]-Oxocarboxylic Acids

    ERIC Educational Resources Information Center

    Kerber, Robert C.; Fernando, Marian S.

    2010-01-01

    Several [alpha]-oxocarboxylic acids play key roles in metabolism in plants and animals. However, there are inconsistencies between the structures as commonly portrayed and the reported acid ionization constants, which result because the acids are predominantly hydrated in aqueous solution; that is, the predominant form is RC(OH)[subscript 2]COOH…

  14. From Alpha to Omega

    ERIC Educational Resources Information Center

    Czaja, Paul Clement

    2006-01-01

    The Alpha point of the authors' life as a Montessori educator began in 1959, when he was a graduate student studying philosophy at Fordham University in the Bronx, New York. While studying the works of the great American philosopher William James, the author came across the writings of Maria Montessori and immediately became captivated by her…

  15. Injectabilite des coulis de ciment dans des milieux fissures

    NASA Astrophysics Data System (ADS)

    Mnif, Thameur

    Le travail presente ici est un bilan du travaux de recherche effectues sur l'injectabilite des coulis de ciment dans lu milieux fissures. Un certain nombre de coulis a base de ciment Portland et microfin ont ete selectionnes afin de caracteriser leur capacite a penetrer des milieux fissures. Une partie des essais a ete menee en laboratoire. L'etude rheologique des differents melanges a permis de tester l'influence de l'ajout de superplastifiant et/ou de fumee de silice sur la distribution granulometrique des coulis et par consequent sur leur capacite a injecter des colonnes de sable simulant un milieu fissure donne. La classe granulometrique d'un coulis, sa stabilite et sa fluidite sont apparus comme les trois facteurs principaux pour la reussite d'une injection. Un facteur de finesse a ete defini au cours de cette etude: base sur la classe granulometrique du ciment et sa stabilite, il peut entrer dans la formulation theorique du debit d'injection avant application sur chantier. La deuxieme et derniere partie de l'etude presente les resultats de deux projets de recherche sur l'injection realises sur chantier. L'injection de dalles de beton fissurees a permis le suivi de l'evolution des pressions avec la distance au point d'injection. L'injection de murs de maconnerie a caractere historique a montre l'importance de la definition de criteres de performance des coulis a utiliser pour traiter un milieu donne et pour un objectif donne. Plusieurs melanges peuvent ainsi etre predefinis et mis a disposition sur le chantier. La complementarite des ciments traditionnels et des ciments microfins devient alors un atout important. Le choix d'utilisation de ces melanges est fonction du terrain rencontre. En conclusion, cette recherche etablit une methodologie pour la selection des coulis a base de ciment et des pressions d'injection en fonction de l'ouverture des fissures ou joints de construction.

  16. Summary of Alpha Particle Transport

    SciTech Connect

    Medley, S.S.; White, R.B.; Zweben, S.J.

    1998-08-19

    This paper summarizes the talks on alpha particle transport which were presented at the 5th International Atomic Energy Agency's Technical Committee Meeting on "Alpha Particles in Fusion Research" held at the Joint European Torus, England in September 1997.

  17. Studiengang:_____________________________________________ Name des/der Stud. Matr. Nr.

    E-print Network

    Wichmann, Felix

    :_____________________________________________ ................................................................. ........................................... Name des/der Stud. Matr. Nr. Titel des Moduls (deutsch

  18. Colloque "Microstructure et Proprietes des Materiaux" ENPC, 17 et 18 mars 2005 MECANIQUE DES ROCHES EN GEOLOGIE : DES PROCESSUS

    E-print Network

    Fortin, Jérôme

    Colloque "Microstructure et Propri´et´es des Mat´eriaux" ENPC, 17 et 18 mars 2005 MECANIQUE DES.gueguen@ens.fr R´esum´e : Le domaine couvert par la M´ecanique des Roches en G´eologie s'´etend sur des ´echelles 1 Introduction La M´ecanique des roches intervient en G´eologie pour tenter d'apporter des r

  19. Analyse des intensités et filtrage des énergies en émission électronique

    NASA Astrophysics Data System (ADS)

    Duval, P.; Blaise, G.; Henry, L.

    1991-10-01

    A different method for using a dispersive system consisting of a magnetic prism and an electrostatic mirror is proposed. This method allows one to study electron intensities and energies coming from the surface of a sample which has been bombarded by an electron beam of a given energy. Le système dispersif constitué d'un prisme magnétique et d'un miroir électrostatique, utilisé jusqu'à présent en microscopie électronique par transmission pour l'analyse et le filtrage des énergies des électrons transmis à travers une couche mince, peut être adapté pour constituer une nouvelle méthode d'étude des intensités et des énergies des électrons diffusés par la surface d'un échantillon bombardé par un faisceau d'électrons d'énergie choisie.

  20. Background canceling surface alpha detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); Allander, Krag S. (Ojo Caliente, NM); Bounds, John A. (Los Alamos, NM)

    1996-01-01

    A background canceling long range alpha detector which is capable of providing output proportional to both the alpha radiation emitted from a surface and to radioactive gas emanating from the surface. The detector operates by using an electrical field between first and second signal planes, an enclosure and the surface or substance to be monitored for alpha radiation. The first and second signal planes are maintained at the same voltage with respect to the electrically conductive enclosure, reducing leakage currents. In the presence of alpha radiation and radioactive gas decay, the signal from the first signal plane is proportional to both the surface alpha radiation and to the airborne radioactive gas, while the signal from the second signal plane is proportional only to the airborne radioactive gas. The difference between these two signals is proportional to the surface alpha radiation alone.

  1. Background canceling surface alpha detector

    DOEpatents

    MacArthur, D.W.; Allander, K.S.; Bounds, J.A.

    1996-06-11

    A background canceling long range alpha detector which is capable of providing output proportional to both the alpha radiation emitted from a surface and to radioactive gas emanating from the surface. The detector operates by using an electrical field between first and second signal planes, an enclosure and the surface or substance to be monitored for alpha radiation. The first and second signal planes are maintained at the same voltage with respect to the electrically conductive enclosure, reducing leakage currents. In the presence of alpha radiation and radioactive gas decay, the signal from the first signal plane is proportional to both the surface alpha radiation and to the airborne radioactive gas, while the signal from the second signal plane is proportional only to the airborne radioactive gas. The difference between these two signals is proportional to the surface alpha radiation alone. 5 figs.

  2. Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis.

    PubMed

    Mason, D Adam; Fleming, Robert J; Goldfarb, David S

    2002-05-01

    Importin alpha's mediate the nuclear transport of many classical nuclear localization signal (cNLS)-containing proteins. Multicellular animals contain multiple importin alpha genes, most of which fall into three conventional phylogenetic clades, here designated alpha1, alpha2, and alpha3. Using degenerate PCR we cloned Drosophila melanogaster importin alpha1, alpha2, and alpha3 genes, demonstrating that the complete conventional importin alpha gene family arose prior to the split between invertebrates and vertebrates. We have begun to analyze the genetic interactions among conventional importin alpha genes by studying their capacity to rescue the male and female sterility of importin alpha2 null flies. The sterility of alpha2 null males was rescued to similar extents by importin alpha1, alpha2, and alpha3 transgenes, suggesting that all three conventional importin alpha's are capable of performing the important role of importin alpha2 during spermatogenesis. In contrast, sterility of alpha2 null females was rescued only by importin alpha2 transgenes, suggesting that it plays a paralog-specific role in oogenesis. Female infertility was also rescued by a mutant importin alpha2 transgene lacking a site that is normally phosphorylated in ovaries. These rescue experiments suggest that male and female gametogenesis have distinct requirements for importin alpha2. PMID:12019231

  3. rencontre du non-lineaire 2000 1 Sur la similitude des morphologies des nervations des feuilles et de

    E-print Network

    Adda-Bedia, Mokhtar

    de celles des fractures Y. Couder*, L. Pauchard**, C. Allain**, M. Adda-Bedia* et S. Douady* *LPS, 24´esentent les formes de ces nervations diff`erent des formes engendr´ees lors de croissances dans des champs possible effet sur la diff´erentiation des nervures. 1 Introduction Les figures form´ees par les nervures

  4. Long range alpha particle detector

    DOEpatents

    MacArthur, D.W.; Wolf, M.A.; McAtee, J.L.; Unruh, W.P.; Cucchiara, A.L.; Huchton, R.L.

    1993-02-02

    An alpha particle detector capable of detecting alpha radiation from distant sources. In one embodiment, a high voltage is generated in a first electrically conductive mesh while a fan draws air containing air molecules ionized by alpha particles through an air passage and across a second electrically conductive mesh. The current in the second electrically conductive mesh can be detected and used for measurement or alarm. The detector can be used for area, personnel and equipment monitoring.

  5. Nuclear Alpha-Particle Condensates

    E-print Network

    T. Yamada; Y. Funaki; H. Horiuchi; G. Roepke; P. Schuck; A. Tohsaki

    2011-03-21

    The $\\alpha$-particle condensate in nuclei is a novel state described by a product state of $\\alpha$'s, all with their c.o.m. in the lowest 0S orbit. We demonstrate that a typical $\\alpha$-particle condensate is the Hoyle state ($E_{x}=7.65$ MeV, $0^+_2$ state in $^{12}$C), which plays a crucial role for the synthesis of $^{12}$C in the universe. The influence of antisymmentrization in the Hoyle state on the bosonic character of the $\\alpha$ particle is discussed in detail. It is shown to be weak. The bosonic aspects in the Hoyle state, therefore, are predominant. It is conjectured that $\\alpha$-particle condensate states also exist in heavier $n\\alpha$ nuclei, like $^{16}$O, $^{20}$Ne, etc. For instance the $0^+_6$ state of $^{16}$O at $E_{x}=15.1$ MeV is identified from a theoretical analysis as being a strong candidate of a $4\\alpha$ condensate. The calculated small width (34 keV) of $0^+_6$, consistent with data, lends credit to the existence of heavier Hoyle-analogue states. In non-self-conjugated nuclei such as $^{11}$B and $^{13}$C, we discuss candidates for the product states of clusters, composed of $\\alpha$'s, triton's, and neutrons etc. The relationship of $\\alpha$-particle condensation in finite nuclei to quartetting in symmetric nuclear matter is investigated with the help of an in-medium modified four-nucleon equation. A nonlinear order parameter equation for quartet condensation is derived and solved for $\\alpha$ particle condensation in infinite nuclear matter. The strong qualitative difference with the pairing case is pointed out.

  6. Long range alpha particle detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); Wolf, Michael A. (Los Alamos, NM); McAtee, James L. (Los Alamos, NM); Unruh, Wesley P. (Los Alamos, NM); Cucchiara, Alfred L. (Los Alamos, NM); Huchton, Roger L. (Los Alamos, NM)

    1993-01-01

    An alpha particle detector capable of detecting alpha radiation from distant sources. In one embodiment, a high voltage is generated in a first electrically conductive mesh while a fan draws air containing air molecules ionized by alpha particles through an air passage and across a second electrically conductive mesh. The current in the second electrically conductive mesh can be detected and used for measurement or alarm. The detector can be used for area, personnel and equipment monitoring.

  7. Juillet 2014 Sur les plages des Canaries, des grains de sable...

    E-print Network

    Huck, Thierry

    1 Juillet 2014 Sur les plages des Canaries, des grains de sable... et des micro-plastiques Les îles Canaries ne sont pas à l'abri de la pollution par les matières plastiques. Mais la localisation des plages'est focalisée sur une des composantes du problème (les micro-plastiques), une région côtière (les îles Canaries

  8. Modeling Solar Lyman Alpha Irradiance

    NASA Technical Reports Server (NTRS)

    Pap, J.; Hudson, H. S.; Rottman, G. J.; Willson, R. C.; Donnelly, R. F.; London, J.

    1990-01-01

    Solar Lyman alpha irradiance is estimated from various solar indices using linear regression analyses. Models developed with multiple linear regression analysis, including daily values and 81-day running means of solar indices, predict reasonably well both the short- and long-term variations observed in Lyman alpha. It is shown that the full disk equivalent width of the He line at 1083 nm offers the best proxy for Lyman alpha, and that the total irradiance corrected for sunspot effect also has a high correlation with Lyman alpha.

  9. Alpha particle confinement in tokamaks

    SciTech Connect

    White, R.B.; Mynick, H.E.

    1988-11-01

    An assessment of diffusive tokamak transport mechanisms of concern for alpha particles indicates that the ''stochastic regime'' is the only one which appears to pose a real danger for adequate alpha confinement. This fact, in conjunction with the threshold character of that mechanism, allows one to decide whether an alpha born at a given location will be lost or confined, according to a very simple criterion. Implementing this criterion numerically results in a new code for the assessment of alpha confinement, which is orders of magnitude faster than earlier codes used for this purpose. 13 refs., 3 figs., 1 tab.

  10. Modlisation des connaissances gographiques Pr. Robert Laurini

    E-print Network

    Laurini, Robert

    Modélisation des connaissances géographiques 1 Pr. Robert Laurini « 80 % des données existantes ont;Modélisation des connaissances géographiques 2 Pr. Robert Laurini 1.1 ­ Modélisation des objets géographiques géographiques 3 Pr. Robert Laurini Géodésie · La terre n'est pas tout à fait ronde ­ ellipsoïde ­ altitude

  11. FLORENT MARTOS Structuration ecologique et evolutive des

    E-print Network

    FLORENT MARTOS Structuration ´ecologique et ´evolutive des symbioses mycorhiziennes des orchid th`ese intitul´ee: Structuration ´ecologique et ´evolutive des symbioses mycorhiziennes des orchid`eces d'orchid´ees actuelles qui d´ependent toutes de champignons mycorhiziens pour accomplir leur cycle

  12. Sciences des aliments Mention : Nutrition, sant, aliments

    E-print Network

    Sart, Remi

    Sciences des aliments Mention : Nutrition, santé, aliments Nature de la formation : Diplôme-Ferrand) #12;2 Sciences des aliments UFR Sciences et Technologies PRÉSENTATION Objectifs Mention Nutrition scientifiques et techniques solides dans le domaine de la Nutrition, des Sciences des Aliments et de la Santé

  13. A Gift to the Alpha Phi Alpha Scholarship Fund

    E-print Network

    Hill, Wendell T.

    A Gift to the Alpha Phi Alpha Scholarship Fund Division of Student Affairs Gifts may also be made online. Please visit sagiving.umd.edu/alphaphialphascholarship and click `Make a Gift Online' at the top Zip Code E-Mail Telephone Business Address City State Zip Code E-Mail Telephone Gift Supporting

  14. Sécurité au-delà des mythes et des croyances

    ScienceCinema

    None

    2011-10-06

    Présentation orale en français, support visuel en français et en anglais. La pire des failles de sécurité est l'impression de sécurité. Le décalage entre la compréhension que l?on a des technologies utilisées, et leurs potentiels réels, ainsi que l'impact potentiellement négatif qu'elles peuvent avoir sur nos vies, n'est pas toujours compris, ou pris en compte par la plupart d'entre-nous. On se contente de nos perceptions pour ne pas avoir à se confronter à la réalité... Alors qu'en est-il vraiment ? En matière de sécurité qui de l'humain ou des technologies a le contrôle ?

  15. DYNAMIQUE DES SYST ` EMES D'ISOM '

    E-print Network

    Gaboriau, Damien

    DYNAMIQUE DES SYST ` EMES D'ISOM ' ETRIES : SUR LES BOUTS DES ORBITES Damien Gaboriau Un syst`eme d'isom ; ' 2 ; : : : ; ' k d'isom'etries entre sous­intervalles ferm'es de D. Ces objets sont des syst : celui des actions de groupes par isom'etries sur des arbres r'eels. Un arbre r'eel est un espace m

  16. DFT CONFORMATIONAL STUDIES OF ALPHA-MALTOTRIOSE

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent DFT optimization studies on alpha-maltose improved our understanding of the preferred conformations of alpha-maltose and the present study extends these studies to alpha-maltotriose with three alpha-D-glucopyranose residues linked by two alpha-[1-4] bridges, denoted herein as DP-3's. Combina...

  17. Fonction diélectrique des milieux inhomogènes

    NASA Astrophysics Data System (ADS)

    Berthier, Serge

    This review article is based on the thesis of Berthier — Laboratoire d'Optique des solides, Université P. et M. Curie— and on various contributions or ulterior works. Its aim is to present a critical and detailed review of the main theories of the optical dielectric function of inhomogeneous media. Together with a mathematical description of the theories, we give a physical interpretation of the results and the practical limits of validity. Each theory is compared to experimental results and other theoretical predictions as well. This study is introduced by theoretical reminders about the electric polarization and considerations about the physical meaning of some fundamental parameters when going from a microscopic to a macroscopic point of view. Cette revue est tirée de la thèse de Berthier préparée au Laboratoire d'Optique des Solides, Université P. et M. Curie, ainsi que des travaux qui lui font suite (thèse en préparation de Driss-Khodja) ou de ceux menés parallèlement (systèmes 2D) par d'autres membres de l'équipe. Son ambition est de présenter une étude approfondie et critique des différentes théories de la fonction diélectrique optique des milieux inhomogènes à trois dimensions. Après une description mathématique détaillée des principales théories, nous donnons une interprétation physique des résultats et les limites concrètes d'utilisation de chacune d'elles. Chaque grande théorie est confrontée à la fois à des résultats expérimentaux et aux prédictions des autres théories. Cette étude est précédée de rappels théoriques sur la polarisation électrique et de considérations sur la signification réelle de certains paramètres lors du passage d'un système microscopique isolé à un système macroscopique aléatoire.

  18. Long-range alpha detector

    SciTech Connect

    MacArthur, D.W.; McAtee, J.L. )

    1991-01-01

    Historically, alpha-particle and alpha-contamination detectors have been limited by the very short range of alpha particles in air and by relatively poor sensitivity even if the particles are intercepted. Alpha detectors have had to be operated in a vacuum or in close proximity to the source if reasonable efficiency is desired. Alpha particles interact with the ambient air, producing ionization in the air at the rate of {approximately}30,000 ion pairs per mega-electron-volt of alpha energy. These charges can be transported over significant distances (several meters) in a moving current of air generated by a small fan. An ion chamber located in front of the fan measures the current carried by the moving ions. The long-range alpha detector (LRAD) offers several advantages over more traditional alpha detectors. First and foremost, it can operate efficiently even if the contamination is not easily accessible. Second, ions generated by contamination in crevices and other unmonitorable locations can be detected if the airflow penetrates those areas. Third, all of the contamination on a large surface will generate ions that can be detected in a single detector; hence, the detector's sensitivity to distributed sources is not limited by the size of the probe. Finally, a simple ion chamber can detect very small electric currents, making this technique potentially quite sensitive.

  19. Alpha particle emitters in medicine

    SciTech Connect

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  20. Alpha Decay Discovery of Radioactivity

    E-print Network

    Smith, Nathanael J.

    Alpha Decay L11-III 1 / 13 #12;Discovery of Radioactivity Radioactivity was discovered by Becquerel://hyperphysics.phy-astr.gsu.edu/hbase/hph.html 2 / 13 #12;Types of Radioactivity emission charge mass identity +2e 4mp He nucleus -e me electron 0 ? EM radiation B radioactive source 3 / 13 #12;Alpha Decay Generic Decay Equation A ZX -- A-4 Z

  1. Alpha 2 agonists and antagonists.

    PubMed

    Paddleford, R R; Harvey, R C

    1999-05-01

    The alpha 2 agonists can produce reliable dose-dependent sedation and analgesia in most species. Nevertheless, they can also produce significant physiological adverse side effects depending on dose, rate, route of administration, and the concurrent use of other CNS depressants. For this reason, it may be best to use a low dose of an alpha 2 agonist as a preanesthetic agent. The alpha 2 agonists are best suited for young, healthy, exercise-tolerant patients. The combining of low doses of alpha 2, opioid, and benzodiazepine agonists results in a synergistic CNS depressant response while minimizing the undesirable side effects of these three classes of drugs. Each group of drugs has specific antagonists available for their reversal, thus allowing veterinarians to reverse one or more of the agonists depending on the desired response. This may represent a significant advantage to the use of low-dose alpha 2 agonists in combination with opioids and benzodiazepines. PMID:10332820

  2. Rgles administratives Carrefour des arts et des sciences

    E-print Network

    Montréal, Université de

    , contrat et responsabilités Les demandes de réservation Frais de location, contrat et responsabilités Contrat - Le locataire doit obligatoirement signer le contrat de location disponible sur le site du Carrefour des arts et

  3. Des widgets aux comets pour la Plasticit des Systmes Interactifs

    E-print Network

    Des widgets aux comets pour la Plasticité des Systèmes Interactifs From widgets to comets utilisabilité. L'article propose une nouvelle génération de widgets, les « comets » (COntext Mouldable widgETs), pour la construction de systèmes interactifs plastiques. Une comet est, par définition, un widget

  4. Fiabilité des structures mécaniques adaptatives: effet de la panne des actionneurs ou des capteurs sur la stabilité

    NASA Astrophysics Data System (ADS)

    Fall, H.; Charon, W.; Kouta, R.

    2002-12-01

    Ces dernières décennies, des activités significatives dans le monde étaient dirigées autour du contrôle actif. Le but de ces recherches était essentiellement d'améliorer les performances, la fiabilité et la sécurité des systèmes. Notamment dans le cas des structures soumises à des vibrations aléatoires. D'importants travaux ont été consacré à l'utilisation des “matériaux intelligents” comme capteurs et actionneurs. Cette article propose l'analyse de la fiabilité des systèmes mécaniques en étudiant les pannes des actionneurs ou des capteurs. L'effet de ces pannes sur la stabilité et la performance du système y est démontré. Les méthodologies de conception y sont rappelées. Des exemples numériques sont fournis à travers le contrôle d'un panneau sous chargement dynamique pour illustrer la méthode proposée.

  5. THE COMPLEX FATE OF ALPHA-KETOACIDS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Plant cells are unique in that they contain four species of alpha-ketoacid dehydrogenase complex: plastidial pyruvate dehydrogenase, mitochondrial pyruvate dehydrogenase, alpha-ketoglutarate (2-oxoglutarate) dehydrogenase, and branched-chain alpha-ketoacid dehydrogenase. All complexes include multi...

  6. 21 CFR 882.1610 - Alpha monitor.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 2010-04-01 2010-04-01 false Alpha monitor. 882.1610 Section 882.1610...Neurological Diagnostic Devices § 882.1610 Alpha monitor. (a) Identification. An alpha monitor is a device with electrodes...

  7. Genetics Home Reference: Alpha-mannosidosis

    MedlinePLUS

    ... PubMed Recent literature OMIM Genetic disorder catalog Conditions > Alpha-mannosidosis On this page: Description Genetic changes Inheritance ... names Glossary definitions Reviewed May 2014 What is alpha-mannosidosis? Alpha-mannosidosis is a rare inherited disorder ...

  8. des sciences Dlai de candidature

    E-print Network

    Halazonetis, Thanos

    faculté des sciences Délai de candidature: Chaque année au 15 mars* Un montant de CHF 10 000.- à 15 archaeology, geology, environmental sciences, pharmacy, and neurosciences. There is also the possibility

  9. Information -Communication Communication des entreprises

    E-print Network

    Sart, Remi

    Information - Communication 2 PARCOURS Communication des entreprises Communication et solidarité;2 Information - Communication UFR Langues Appliquées, Commerce et Communication PRÉSENTATION Objectifs La Licence Information et communication est destinée aux étudiants qui souhaitent suivre un parcours

  10. Jahresbericht des Instituts fr Kognitionswissenschaft

    E-print Network

    Kallenrode, May-Britt

    die Arbeitsgruppe Philosophie des Geistes und der Kognition. Darüber hinaus wurde Prof. Dr. Robert C. Richardson (Cincinnati) das erste und landesweit einzige Gervinus-Fellowship zugesprochen, der damit ab 2008

  11. Thorie des probabilits LAVOISIER, 2008

    E-print Network

    Rioul, Olivier

    Théorie des probabilités #12;© LAVOISIER, 2008 LAVOISIER 11, rue Lavoisier 75008 Paris www.hermes-science.com www.lavoisier.fr ISBN 978-2-7462-1720-1 ISSN 1952­2401 Le Code de la propriété intellectuelle n

  12. Comprendre le langage des toiles

    E-print Network

    Le Coroller, Hervé

    spectre. #12;Un spectre dans la nature Le spectre le plus simple est l'arc- en a expliqué l'origine de l'arc-en-ciel. #12;Le secret des spectres Mais il a fallu'est au début du 19ème siècle que l'on a découvert le secret des spectres

  13. Alpha detection on moving surfaces

    SciTech Connect

    MacArthur, D.; Orr, C.; Luff, C.

    1998-12-01

    Both environmental restoration (ER) and decontamination and decommissioning (D and D) require characterization of large surface areas (walls, floors, in situ soil, soil and rubble on a conveyor belt, etc.) for radioactive contamination. Many facilities which have processed alpha active material such as plutonium or uranium require effective and efficient characterization for alpha contamination. Traditional methods for alpha surface characterization are limited by the short range and poor penetration of alpha particles. These probes are only sensitive to contamination located directly under the probe. Furthermore, the probe must be held close to the surface to be monitored in order to avoid excessive losses in the ambient air. The combination of proximity and thin detector windows can easily cause instrument damage unless extreme care is taken. The long-range alpha detection (LRAD) system addresses these problems by detecting the ions generated by alpha particles interacting with ambient air rather than the alpha particle directly. Thus, detectors based on LRAD overcome the limitations due to alpha particle range (the ions can travel many meters as opposed to the several-centimeter alpha particle range) and penetrating ability (an LRAD-based detector has no window). Unfortunately, all LRAD-based detectors described previously are static devices, i.e., these detectors cannot be used over surfaces which are continuously moving. In this paper, the authors report on the first tests of two techniques (the electrostatic ion seal and the gridded electrostatic LRAD detector) which extend the capabilities of LRAD surface monitors to use over moving surfaces. This dynamic surface monitoring system was developed jointly by Los Alamos National Laboratory and at BNFL Instruments. All testing was performed at the BNFL Instruments facility in the UK.

  14. Alpha-particle spectrometer experiment

    NASA Technical Reports Server (NTRS)

    Gorenstein, P.; Bjorkholm, P.

    1972-01-01

    Mapping the radon emanation of the moon was studied to find potential areas of high activity by detection of radon isotopes and their daughter products. It was felt that based on observation of regions overflown by Apollo spacecraft and within the field of view of the alpha-particle spectrometer, a radon map could be constructed, identifying and locating lunar areas of outgassing. The basic theory of radon migration from natural concentrations of uranium and thorium is discussed in terms of radon decay and the production of alpha particles. The preliminary analysis of the results indicates no significant alpha emission.

  15. Alpha--College for Exploring

    ERIC Educational Resources Information Center

    Leppert, William; Koenig, Joan

    1976-01-01

    Describes Alpha, the experimental college of individualized instruction at the College of DuPage (Illinois). At this college, students design their own curricula and work in an open classroom situation, and teachers start with students instead of subjects. (DC)

  16. The Alpha-Beta Heuristic

    E-print Network

    Edwards, D.J.

    1961-12-01

    The Alpha-Beta heuristic is a method for pruning unneeded branches from the move tree of a game. The algorithm makes use of information gained about part of the tree to reject those branches which will not affect the ...

  17. Genetics Home Reference: Alpha thalassemia

    MedlinePLUS

    ... with the characteristic features of alpha thalassemia, a reduction in the amount of hemoglobin prevents enough oxygen ... January 4, 2016 Lister Hill National Center for Biomedical Communications U.S. National Library of Medicine , National Institutes ...

  18. Alpha decay in electron surrounding

    SciTech Connect

    Igashov, S. Yu.; Tchuvil’sky, Yu. M.

    2013-12-15

    The influence of atomic electron shells on the constant of alpha decay of heavy and mediummass nuclei was considered in detail. A method for simultaneously taking into account the change in the potential-barrier shape and the effect of reflection of a diverging Coulomb wave in the classically allowed region was developed. The ratios of decay probabilities per unit time for a bare nucleus and the respective neutral atom were found for some alpha-decaying isotopes.

  19. Long-range alpha detection

    SciTech Connect

    Kasper, K.

    1998-12-01

    The detection and measurement of alpha contamination is not an easy task. An alpha particle`s characteristic high charge and large mass make it highly interactive with surrounding matter. The particle is often absorbed before its presence can be sensed with a detector. Los Alamos National Laboratory has studied this problem and has developed an improved process to detect alpha-emitting contaminants. The process is called long-range alpha detection (LRAD). The LRAD process focuses on the collection and measurement of ions created as a result of an alpha particle`s interaction with air. With only about 35 eV necessary to create an ion pair, a typical 5-MeV alpha particle, upon emission from its maternal nucleus, creates about 150,000 pairs of charged particles. In air these charged particles take several seconds to locate a mate and become electrically neutral. During this time, ions can be pulled away from the source, collected, and measured. Ions can be motivated to a collection device by using an electric field or by moving the air mass in which the ions are located. The collected charges create a small but discrete current that can give some useful information about the alpha-emitting source. In this article, two commercially available applications of the LRADS technology will be discussed. One of these, a device used primarily for pipe monitoring, is from BNFL Instruments, Inc. The other is a monitoring box of sorts from Eberline that will produce an alpha measurement on anything that is placed in the box.

  20. Structure, caractrisation et comportement mcanique des failles sismiques : Etude des pseudotachylites et gouges

    E-print Network

    Demouchy, Sylvie

    Structure, caractérisation et comportement mécanique des failles sismiques : Etude des pseudotachylites et gouges Résumé L'objectif de ce projet est de mieux caractériser la structure et la formation des processus de formation des failles actives en prenant comme objet d'étude les gouges de failles et

  1. Nr. 057 / 2014 // 3. April 2014 Knstlerische Darstellung des ,,Giant impact", des Aufpralls eines kleineren

    E-print Network

    Schittkowski, Klaus

    Nr. 057 / 2014 // 3. April 2014 1/7 Künstlerische Darstellung des ,,Giant impact", des Aufpralls freundlicher Genehmigung des NASA/Jet Propulsion Labors am California Institute of Technology. In ,,Nature- zeichnet. Der ,,Giant impact" und seine Folgen: Die Entstehung des Mondes und Veränderungen im Erdmantel

  2. Des Lacs River and Souris River

    USGS Multimedia Gallery

     The Des Lacs River coming in to the Souris River. Des Lacs River is the darker water, which is sediment and the Souris River is the lighter water. >Photo taken by USGS personnel on a Civil Air Patrol flight....

  3. Peste des petits ruminants

    PubMed Central

    Parida, S.; Muniraju, M.; Mahapatra, M.; Muthuchelvan, D.; Buczkowski, H.; Banyard, A.C.

    2015-01-01

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  4. Peste des petits ruminants.

    PubMed

    Parida, S; Muniraju, M; Mahapatra, M; Muthuchelvan, D; Buczkowski, H; Banyard, A C

    2015-12-14

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. PMID:26443889

  5. Diffusion incohérente des neutrons : modèles analytiques pour la dynamique interne des protéines

    NASA Astrophysics Data System (ADS)

    Bicout, D. J.

    2005-11-01

    La dynamique interne des protéines joue un rôle central dans la stabilité, la fonction et l'activité biologique de ces biomolécules. Il est maintenant établi que les fluctuations d'états conformationnels des protéines influencent fortement la plupart des réactions biochimiques et s'accompagnent d'une augmentation brutale des déplacements carrés moyens des atomes au dessus de la température de la transition dynamique. Dans cette contribution, nous présentons une revue critique de quelques modèles théoriques couramment utilisés dans la littérature pour l'analyse des mouvements internes des protéines et la description de la transition dynamique.

  6. 21 CFR 882.1610 - Alpha monitor.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Alpha monitor. 882.1610 Section 882.1610 Food and... NEUROLOGICAL DEVICES Neurological Diagnostic Devices § 882.1610 Alpha monitor. (a) Identification. An alpha... electroencephalogram which is referred to as the alpha wave. (b) Classification. Class II (performance standards)....

  7. 21 CFR 882.1610 - Alpha monitor.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Alpha monitor. 882.1610 Section 882.1610 Food and... NEUROLOGICAL DEVICES Neurological Diagnostic Devices § 882.1610 Alpha monitor. (a) Identification. An alpha... electroencephalogram which is referred to as the alpha wave. (b) Classification. Class II (performance standards)....

  8. alpha_s determinations from ATLAS (status and plans)

    E-print Network

    Malaescu, Bogdan; The ATLAS collaboration

    2015-01-01

    Common for all the contributions: "This document collects a summary of all contributions of the workshop on "High precision measurements of alpha_s: from LHC to FCC-ee" held at CERN, October 12-13, 2015 (http://indico.cern.ch/e/alphas2015). The workshop explored in depth the latest developments on the determination of the QCD coupling alpha_s from the key categories where high precision measurements are (or will be) available. Those include low-energy observables: (i) lattice QCD, (ii) pion decay factor, (iii) quarkonia and (iv) tau decays, (v) soft parton-to-hadron fragmentation functions; as well as high-energy observables: (vi) global fits of parton distribution functions, (vii) hard parton-to-hadron fragmentation functions, (viii) jets in e+--p DIS and photoproduction, (ix) event shapes and (x) jet cross sections in e+e- collisions, (xi) W boson and (xii) Z boson decays, and (xiii) top-quark and (xiv) jet cross sections in p-p collisions. The current status of the theoretical and experimental uncertaintie...

  9. L'astronomie des Anciens

    NASA Astrophysics Data System (ADS)

    Nazé, Yaël

    2009-04-01

    Quelle que soit la civilisation à laquelle il appartient, l'être humain cherche dans le ciel des réponses aux questions qu'il se pose sur son origine, son avenir et sa finalité. Le premier mérite de ce livre est de nous rappeler que l'astronomie a commencé ainsi à travers les mythes célestes imaginés par les Anciens pour expliquer l'ordre du monde et la place qu'ils y occupaient. Mais les savoirs astronomiques passés étaient loin d'être négligeables et certainement pas limités aux seuls travaux des Grecs : c'est ce que l'auteur montre à travers une passionnante enquête, de Stonehenge à Gizeh en passant par Pékin et Mexico, fondée sur l'étude des monuments anciens et des sources écrites encore accessibles. Les tablettes mésopotamiennes, les annales chinoises, les chroniques médiévales, etc. sont en outre d'une singulière utilité pour les astronomes modernes : comment sinon remonter aux variations de la durée du jour au cours des siècles, ou percer la nature de l'explosion qui a frappé tant d'observateurs en 1054 ? Ce livre offre un voyage magnifiquement illustré à travers les âges, entre astronomie et archéologie.

  10. Exploration des mécanismes de repliement des protéines par dynamique moléculaire

    NASA Astrophysics Data System (ADS)

    Gilquin, B.

    2005-11-01

    Comment se replient les protéines? Cette question est ancienne. En introduction nous rappellerons ce qu'est le paradoxe de Levinthal et comment on est passé de la notion de chemin de repliement à la notion de paysage énergétique. Les simulations de dynamique moléculaire ont permis d'aborder la compréhension du processus de repliement au niveau atomique. Cependant l'échelle de temps des processus de repliement (de l'ordre de la milliseconde) n'est pas accessible aux simulations numériques (de l'ordre de la nanoseconde). Plusieurs auteurs ont donc proposé de simuler le dépliement des protéines par dynamique moléculaire. En admettant le principe de micro-réversibilité l'étude du processus de dépliement renseigne sur celui de repliement. Cependant, il est nécessaire d'accélérer le dépliement en introduisant un biais afin que les états dépliées soient accessibles aux échelles de temps des simulations. Nous présenterons un exemple de ce qui a été réalise dans le cas de l'étude de protéines de petite taille suivant un repliement simple, globalement à deux états. Nous présenterons ensuite ce que nous avons réalisé dans le cas d'une protéine de taille plus importante et pour laquelle le processus de repliement est plus complexe car il existe un intermédiaire transitoire de repliement. C'est le cas du lysozyme pour lequel les simulations de dépliement permettent d'accéder au mécanisme atomique de repliement et de comprendre pourquoi des mutants de cette protéine se replient plus lentement et forment des fibres amyloïdiques. Ainsi les intermédiaires de repliement seraient à l'origine de formes pathogènes des protéines observées dans les maladies neuro-dégéneratives. Enfin nous montrerons comment à partir de plusieurs simulations longues de dynamique moléculaire, le paysage énergétique pour de petites protéines peut être calculé.

  11. [Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].

    PubMed

    Ono, Kenjiro; Yamada, Masahito

    2014-03-01

    Alpha-Synuclein protein(alphaS) aggregates from a monomer to assemblies such as oligomers, protofibrils, and mature fibrils. The early intermediate aggregate, that is, the oligomer, has been reported to be the most toxic species. We recently reported that melatonin inhibits alphaS aggregation, including protofibril and oligomer formations. While the alphaS concentration in cerebrospinal fluid was reported to significantly decrease in patients with Parkinson's disease (PD) and dementia with Lewy bodies, there have been reports that the alphaS oligomer concentration was elevated in the cerebrospinal fluid of PD patients. Moreover, it was reported that the alphaS oligomer concentration was also elevated in the blood of PD patients. Further studies may establish alphaS in cerebrospinal fluid and blood as a biomarker of alpha-synucleinopathies, including PD. PMID:24800499

  12. Ansprache des Prsidenten anlsslich der Festveranstaltung

    E-print Network

    Falge, Eva

    Ansprache des Präsidenten anlässlich der Festveranstaltung zum 100jährigen Jubiläum des Fritz-Haber herzlich willkommen, 100 Jahre Fritz-Haber-Institut bzw. Kaiser-Wilhelm-Institut für physikalische Chemie heute einen Einblick geben in 100 Jahre Fritz-Haber-Institut. MAX-PLANCK-GESELLSCHAFT Rede des

  13. Descriptif des fonctions postules CORPS EMPLOIS

    E-print Network

    Pouyanne, Nicolas

    - Architecte des systèmes d'information - Chef de projet ou expert en développement et déploiement d - Architecte des systèmes d'information - Chef de projet ou expert en développement et déploiement d télécommunications - Ingénieur statisticien - Ingénieur en calcul scientifique IR - Architecte des systèmes d

  14. Direction de la documentation, des archives

    E-print Network

    Ghorbel, Amin

    le travail des groupes. Désormais au nombre de trois, les espaces- projets ont fait l'objet de plus Bibliothèque #12;5 Le succès des espaces-projets de la Bibliothèque Pour toujours mieux répondre aux attentes des élèves, une nouvelle salle de travail, la salle Jean Rouch, a été ouverte en septembre 2014 au

  15. Emmanuel Frenod Professeur des Universites -Mathematiques Appliquees

    E-print Network

    Frénod, Emmanuel

    Emmanuel Fr´enod Professeur des Universit´es - Math´ematiques Appliqu´ees Professor - Applied, ´equations cin´etiques, homog´en´eisation, m´ethodes math´ematiques de mod´elisation, analyse num´erique, calcul scientifique, Lo- giciels encapsulant des math´ematiques, mod´elisation des environnements

  16. Mechanism of alpha-tocopheryl-phosphate (alpha-TP) transport across the cell membrane

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We have reported that alpha-TP is synthesized and hydrolyzed in animal cells and tissues; it modulates also several cell functions (FRBM 39:970, and UBMB Life, 57:23, 2005). While it is similar to alpha-tocopherol (alpha-T), alpha-TP appears to be more potent than alpha-T in inhibiting cell prolifer...

  17. Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The naturally occurring vitamin E analogue, alpha-tocopheryl phosphate (alphaTP), has been reported to be more potent in reducing cell proliferation and the expression of the CD36 scavenger receptor than the un-phosphorylated alpha-tocopherol (alpha T). We have now assessed the effects of alpha T an...

  18. Mouse. cap alpha. -globin genes and. cap alpha. -globin-like pseudogenes are not syntenic

    SciTech Connect

    Popp, R.A.; Lalley, P.A.; Whitney, J.B.; Anderson, W.F.

    1981-10-01

    A genetic polymorphism for a Bgl I endonuclease site near the ..cap alpha..-globin-like pseudogene ..cap alpha..-4 of C57BL/6 and C3H/HeN mice was used to show that ..cap alpha..-4 was not affected by three independent mutations in which the adult globin genes ..cap alpha..-1 and ..cap alpha..-2 were deleted. These results indicated that ..cap alpha..-4 might not be located adjacent to the adult ..cap alpha..-globin genes on chromosome 11. Restriction endonuclease analysis of DNA of a primary clone of a Chinese hamster-mouse somatic cell hybrid that had lost mouse chromosomes 11 and 18 showed that this clone lacked the adult murine globin genes ..cap alpha..-1 and ..cap alpha..-2 but it did contain the ..cap alpha..-globin-like pseudogenes ..cap alpha..-3 and ..cap alpha..-4. These results indicated that the adult ..cap alpha..-globin genes and ..cap alpha..-globin-like pseudogenes are not located on the same chromosome. Similar analyses of several other Chinese hamster-mouse somatic cell hybrids that had segregated other mouse chromosomes indicated that the ..cap alpha..-globin-like pseudogenes ..cap alpha..-3 and ..cap alpha..-4 are located on mouse chromosomes 15 and 17, respectively. These data explain why ..cap alpha..-3 and ..cap alpha..-4 were not affected by the three independently induced deletion-type mutations that cause ..cap alpha..-thalassemia in the mouse.

  19. Infections fongiques des brûlé : revue

    PubMed Central

    Arnould, JF.; Le Floch, R.

    2015-01-01

    Summary Les infections fongiques locales ou générales sont souvent d’une extrême gravité chez les brûlés. Les brûlés combinent de nombreux facteurs de risque à une immunodépression induite par la brûlure. Les infections de plaies sont le fait des genres Candida, Aspergillus et des agents de mucormycoses. Ces deux derniers cas sont à l’origine de lésions particulièrement sévères. Leur diagnostic repose sur la biopsie cutanée avec examens mycologique et anatomopathologique. Le traitement est essentiellement chirurgical, associé à une antibiothérapie adaptée. Les septicémies sont le fait de levures, essentiellement du genre Candida. Le diagnostic en est difficile dans le contexte des brûlés et repose souvent sur une forte suspicion clinique. Leur traitement repose sur les échinocandines et plus secondairement sur le fluconazole. PMID:26668558

  20. Workshop on Precision Measurements of $\\alpha_s$

    SciTech Connect

    Bethke, Siegfried; Hoang, Andre H.; Kluth, Stefan; Schieck, Jochen; Stewart, Iain W.; Aoki, S.; Beneke, M.; Bethke, S.; Blumlein, J.; Brambilla, N.; Brodsky, S.; /MIT, LNS

    2011-10-01

    These are the proceedings of the Workshop on Precision Measurements of {alpha}{sub s} held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of {alpha}{sub s}(m{sub Z}) in the {ovr MS} scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, {tau}-decays, electro-weak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  1. Alpha-Driven MHD MHD-Induced Alpha Loss

    E-print Network

    Budny, Robert

    plasmas. 0 0.2 0.4 0.6 0 2 4 6 8 (0) B [mG] ~ ×10-4 TAE q(0)~1.1-1.2q(0)~1.9-2.4 noise #12;Importance 1 0 4 (mG) Bp ~ high-field-side low-field-side high-field-side (mG) Bp ~ (mG) Bp ~ · #12;No Alpha Princeton Plasmas Physics Laboratory APS Invited talk November 1996, Denver #12;Introduction TFTR · Alpha

  2. Classification of 4 DES supernovae by OzDES

    NASA Astrophysics Data System (ADS)

    Glazebrook, K.; Amon, A.; Lidman, C.; Martini, P.; Tucker, B. E.; Yuan, F.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  3. Classification of 15 DES supernovae by OzDES

    NASA Astrophysics Data System (ADS)

    Yuan, F.; Tucker, B. E.; Lidman, C.; Martini, P.; Gshwend, Julia; Moller, A.; Zhang, B.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  4. Classification of 20 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Davis, T. M.; Kim, A. G.; Macualay, E.; Lidman, C.; Sharp, R.; Tucker, B. E.; Yuan, F.; Zhang, B.; Lewis, G. F.; Sommer, N. E.; Martini, P.; Mould, J.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.

    2015-12-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  5. Classification of 14 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Tucker, B. E.; Sharp, R.; Yuan, F.; Zhang, B.; Lidman, C.; Davis, T. M.; Hinton, S.; Mould, J.; Smith, R. C.; Schubnell, M.; Kessler, R.; Scolnic, D.; Covarrubias, R. A.; Brout, D. J.; Fischer, J. A.; Gladney, L.; March, M.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; D'Andrea, C.; Smith, M.; Sullivan, M.; Childress, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Castander, F. J.; Desai, S.; Paech, K.

    2015-10-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey. The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  6. Classification of 6 DES Supernova with OzDES

    NASA Astrophysics Data System (ADS)

    Lewis, G. F.; Mould, J.; Lidman, C.; Tucker, B. E.; Sharp, R.; Yuan, F.; Martini, P.; Kessler, R.; Scolnic, D.; Covarrubias, R. A.; Brout, D. J.; Fischer, J. A.; Gladney, L.; March, M.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; D'Andrea, C.; Smith, M.; Sullivan, M.; Childress, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.

    2015-10-01

    We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

  7. Space Station alpha joint bearing

    NASA Technical Reports Server (NTRS)

    Everman, Michael R.; Jones, P. Alan; Spencer, Porter A.

    1987-01-01

    Perhaps the most critical structural system aboard the Space Station is the Solar Alpha Rotary Joint which helps align the power generation system with the sun. The joint must provide structural support and controlled rotation to the outboard transverse booms as well as power and data transfer across the joint. The Solar Alpha Rotary Joint is composed of two transition sections and an integral, large diameter bearing. Alpha joint bearing design presents a particularly interesting problem because of its large size and need for high reliability, stiffness, and on orbit maintability. The discrete roller bearing developed is a novel refinement to cam follower technology. It offers thermal compensation and ease of on-orbit maintenance that are not found in conventional rolling element bearings. How the bearing design evolved is summarized. Driving requirements are reviewed, alternative concepts assessed, and the selected design is described.

  8. Paternité des articles et intérêts concurrents : une analyse des recommandations aux auteurs des journaux traitant de pratique pharmaceutique

    PubMed Central

    Courbon, Ève; Tanguay, Cynthia; Lebel, Denis; Bussières, Jean-François

    2014-01-01

    RÉSUMÉ Contexte : La présence d’auteurs honorifiques et fantômes ainsi que les intérêts concurrents représentent des difficultés bien documentées, liées à la publication d’articles scientifiques. Il existe des lignes directrices encadrant la rédaction et la publication de manuscrits scientifiques, notamment celles de l’International Committee of Medical Journal Editors (ICMJE). Objectifs : L’objectif principal de cette étude descriptive et transversale visait à recenser les instructions portant sur la paternité des articles et les intérêts concurrents provenant des recommandations aux auteurs des journaux traitant de pratique pharmaceutique. L’objectif secondaire visait à déterminer des mesures correctrices pour une paternité des articles plus transparente. Méthode : La recherche a débuté par l’identification des journaux traitant de pratique pharmaceutique. La consultation des instructions aux auteurs des journaux a permis ensuite de recenser les recommandations destinées à éviter les problèmes de paternité des articles et d’intérêts concurrents. Finalement, les membres de l’équipe de recherche se sont consultés afin de définir des mesures correctrices possibles à l’intention des chercheurs. Résultats : Des 232 journaux traitant de pharmacie, 33 ont été définis comme traitant de pratique pharmaceutique. Un total de 24 (73 %) journaux mentionnaient suivre la politique de l’ICMJE, 14 (42 %) demandaient aux auteurs de remplir un formulaire de déclaration d’intérêts concurrents au moment de la soumission de l’article, 17 (52 %) présentaient une définition de la qualité d’auteur et 5 (15 %) demandaient de détailler les contributions de chaque auteur. Une grille de 40 critères a été élaborée pour définir l’attribution du statut d’auteur. Conclusion : Moins de la moitié des journaux demandait aux auteurs de transmettre un formulaire de déclaration des intérêts concurrents au moment de la soumission d’un article et seulement la moitié des journaux avait donné une définition de la qualité d’auteur. La publication scientifique de travaux sur les pratiques pharmaceutiques n’est pas à l’abri des manques de transparence liés à la publication. L’utilisation d’une grille décrivant la contribution de chaque auteur et la publication en ligne des travaux peuvent contribuer à limiter ces risques. PMID:24970938

  9. Transport quantique dans des nanostructures

    NASA Astrophysics Data System (ADS)

    Naud, C.

    2002-09-01

    Quantum transport in nanostructures This work is devoted to the design, fabrication and magnetotransport investigations of mesoscopic devices. The sample are obtain by e-beam lithography and the measurements are performed at low temperature in a dilution refrigerator in the presence of a magnetic field. We have used MBE grown AlGaAs/GaAs heterojonctions as starting material to fabricate a bipartite tiling of rhombus called mathcal{T}3 lattice. We observe for the first time large amplitude h/e oscillations in this network as compared to the one measured in square lattices of similar size. These oscillations are the signature of a recently predited localization phenomenon induced by Aharonov-Bohm interferences on this peculiar topology. For particular values of the magnetic field the propagation of the electron wave function is bounded in a small number of cells, called Aharonov-Bohm cages. More strikingly, at high magnetic field, h/2e oscillations appear whose amplitude can be much higher than the fundamental period. Their temperature dependence is similar to that of the h/e signal. These observations withdraw a simple interpretation in terms of harmonics generation. The origin of this phenomenon is still unclear and needs more investigations. The influence electrical width of the wire defining the network and so the rule of the number of channels can be studied using a gate deposited over the lattice. In particular we have measured the amplitude dependence of the h/e and h/2e signal versus the gate voltage. Ce travail est consacré à la réalisation d'échantillons mésoscopiques à partir de la lithographie électronique ainsi qu'à leur caractérisation à très basse température en magnétotransport. Nous avons pour cela exploité le gaz bidimensionnel d'électrons situé à l'interface d'une hétérojonction AlGaAs/GaAs pour réaliser un réseau de boucle d'une géométrie particulière baptisée la géométrie mathcal{T}3. Nous avons observé sur cette structure des oscillations de conductance en fonction du flux du champ magnétique de période h/e dont l'amplitude est beaucoup plus importante que celle mesurée sur un réseau carré de même dimension. Cette différence constitue une signature d'un effet de localisation induit par le champ magnétique sur la topologie mathcal{T}3. Pour des valeurs spécifiques du champ magnétique, du fait des interférences destructives Aharonov-Bohm, la propagation des fonctions d'ondes est limitée à un ensemble fini de cellule du réseau appelé cage. De la dépendance en température des oscillations de période h/e mesurées sur le réseau mathcal{T}3 nous avons tiré une longueur caractéristique qui peut être rattachée au périmètre des cages. Un phénomène inattendu fut l'observation, pour des champs magnétiques plus importants, d'un doublement de fréquence des oscillations. Ces oscillations de période h/2e pouvant avoir une amplitude supérieure aux oscillations de période h/e, une interprétation en terme d'harmonique n'est pas possible. Enfin, l'influence de la largeur électrique des fils constituant le réseau et donc celle du nombre de canaux par brin a été étudiée en réalisant des grilles électrostatique. Les variations de l'amplitude des signaux en h/e et h/2e en fonction de la tension de grille ont été mesurés.

  10. Long-range alpha detector sample monitoring

    NASA Astrophysics Data System (ADS)

    Johnson, J. D.; Allander, K. S.; Bounds, J. A.; Garner, S. E.; Johnson, J. P.; MacArthur, D. W.; Sprouse, L. L.; Walters, S. G.

    1994-12-01

    Long-range alpha detector (LRAD) systems are designed to monitor alpha sources and contamination by measuring the number of ions created in air by ionizing radiation. Traditional alpha detectors are designed to detect alpha particles directly and must be passed slowly within about 3 cm of an alpha source to operate effectively. LRAD detectors collect the ions created from alpha interactions with air. Therefore, they are better able to monitor equipment and complex surfaces and can be operated at a much greater distance from an alpha source than traditional alpha detectors. Furthermore, because LRAD detectors remain stationary during monitoring, they are less subject to operator error than traditional alpha detectors. This paper will discuss the basic operation as well as recent advances that have been made to LRAD Sample Monitors.

  11. Possible paracrine function of alpha-melanocyte-stimulating hormone and inhibition of its melanin-dispersing activity by N-terminal acetylation in the skin of the barfin flounder, Verasper moseri.

    PubMed

    Kobayashi, Yuki; Mizusawa, Kanta; Yamanome, Takeshi; Chiba, Hiroaki; Takahashi, Akiyoshi

    2009-05-01

    Melanocyte-stimulating hormone (MSH) is generated from a precursor protein, proopiomelanocortin (POMC), mainly in the pituitary. The barfin flounder, Verasper moseri, expresses three different POMC genes (Pomc), among which Pomc-c is also expressed in the skin. Herein, we characterized the biological significance of POMC and MSH produced in barfin flounder skin. The reverse transcription polymerase chain reaction showed the expression of Pomc-c in isolated non-chromatophoric dermal cells. Mass spectrometry analyses of fractions of skin extract separated by high-performance liquid chromatography revealed the presence of a peptide with a molecular mass corresponding to Des-acetyl (Ac)-alpha-MSH-C derived from POMC-C. These results indicate that, in addition to endocrine functions, MSH in barfin flounder is associated with skin pigmentation via paracrine mechanisms. On the other hand, in vitro studies showed that Des-Ac-alpha-MSH-C dispersed pigments in both melanophores and xanthophores. These functions are similar to those of Des-Ac-alpha-MSH, which differs from Des-Ac-alpha-MSH-C only at the C-terminus, generated from POMC-A and -B. Alpha-MSH, which has an acetyl group at the N-terminus, led to pigment dispersion in xanthophores, but showed no effect in melanophores. A series of bioassays indicated that acetylation enhances MSH activity in xanthophores, but inhibits it in melanophores, suggesting that receptors for MSHs expressed in xanthophores and melanophores are different from each other. PMID:19245814

  12. hors les murs des plantes

    E-print Network

    hors les murs au jardin des plantes 16 oct./ 201523 nov. mnhn.fr -- fiac.com 57 rue Cuvier -- Paris Georges-Philippe et Nathalie Vallois, Paris 5 - Lara Almarcegui Rocks of Spitsbergen, 2014, Présentée par 11 - Virginie Yassef L'objet du doute, 2013 Présentée par la Galerie Georges-Philippe et Nathalie

  13. DIRECTEUR DU CENTRE DES HUMANITS

    E-print Network

    Fiore, Marco

    activité profes- sionnelle. Les cours de connaissance de l'entreprise et de management visent cette transversale de cinquième année consacrée à l'innovation et à la créativité. Il est impliqué dans le projet d campus, l'INSA Lyon propose un véri- table environnement où la créativité artistique et culturelle des

  14. Deuxi eme partie Structure des ^

    E-print Network

    Clouard, Valerie

    and depth of frozen magma chambers under atolls and islands of French Polynesia using detailed gravity des ^ les et atolls de Polyn esie francaise qui a donn e lieu #12;a une publication dans le Journal under atolls and islands of French Polynesia using detailed gravity studies" R esum e De nouvelles

  15. Meet the Alpha-Pets.

    ERIC Educational Resources Information Center

    Zitlaw, Jo Ann Bruce; Frank, Cheryl Standish

    1985-01-01

    "Alpha-Pets" are the focal point of an integrated, multidisciplinary curriculum. Each pet is featured for a week in a vocabulary-rich story and introduces related activities beginning with the featured letter, such as the four food groups during Freddie Fish's week or universe during Ulysses Unicorn's week. (MT)

  16. Alpha Testing Escape from Diab

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Alpha testing was conducted of sessions 2 and 3 from Diab to assess whether the activities worked as expected, and whether children in the target ages enjoyed it. Data include both RA observations of child performance while playing the games and cognitive interview responses from the players after t...

  17. Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate in thp-1 monocytes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The naturally occurring vitamin E analogue, alpha-tocopheryl phosphate (alphaTP), has been reported to be more potent than the un-phosphorylated alpha alpha-tocopherol (alphaT). We have now measured plasma levels of alphaTP and compared the cellular effects of alphaTP and gamma-tocopheryl phosphate ...

  18. Coexistence of {alpha}+{alpha}+n+n and {alpha}+t+t cluster structures in {sup 10}Be

    SciTech Connect

    Itagaki, N.; Ito, M.; Milin, M.; Hashimoto, T.; Ishiyama, H.; Miyatake, H.

    2008-06-15

    The coexistence of the {alpha}+{alpha}+n+n and {alpha}+t+t cluster structures in the excited states of {sup 10}Be has been discussed. In the previous analysis, all the low-lying states of {sup 10}Be were found to be well described by the motion of the two valence neutrons around two {alpha} clusters. However, the {alpha}+t+t cluster structure was found to coexist with the {alpha}+{alpha}+n+n structure around E{sub x}=15 MeV, close to the corresponding threshold. We have introduced a microscopic model to solve the coupling effect between these two configurations. The K=0 and K=1 states are generated from the {alpha}+t+t configurations due to the spin coupling of two triton clusters. The present case of {sup 10}Be is one of the few examples in which completely different configurations of triton-type ({alpha}+t+t three-center) and {alpha}-type ({alpha}+{alpha}+n+n two-center) clusters coexist in a single nucleus in the same energy region.

  19. How Is Alpha-1 Antitrypsin Deficiency Treated?

    MedlinePLUS

    ... from the NHLBI on Twitter. How Is Alpha-1 Antitrypsin Deficiency Treated? Alpha-1 antitrypsin (AAT) deficiency has no cure, but its ... of these treatments are the same as the ones used for a lung disease called COPD (chronic ...

  20. What Causes Alpha-1 Antitrypsin Deficiency?

    MedlinePLUS

    ... from the NHLBI on Twitter. What Causes Alpha-1 Antitrypsin Deficiency? Alpha-1 antitrypsin (AAT) deficiency is an inherited disease. "Inherited" ... have AAT deficiency inherit two faulty AAT genes, one from each parent. These genes tell cells in ...

  1. Environmental alpha contamination monitoring with the LRAD

    SciTech Connect

    MacArthur, D.W.; Allander, K.S.; Bounds, J.A.; Catlett, M.M.; Caress, R.W.; Rutherford, D.A.

    1993-12-31

    Traditional alpha detection systems used for environmental analysis of potential alpha contamination are hampered by relative poor sensitivity and by the short range of alpha particles in air. The long-range alpha detector (LRAD) addresses both of these limitations by detecting the ionized gas molecules created by the alpha particles` interaction with the ambient air, rather than the alpha particles themselves. In addition, LRAD monitors are sensitive to contamination in any location to which air can penetrate and are able to monitor large surfaces simultaneously. All of these characteristics are important in environmental monitoring for alpha contamination. The authors will present the basic LRAD technology as well as applications to soil, water, and air monitors. Results from field tests of several of these alpha monitors will be presented.

  2. Genetics Home Reference: Alpha-1 antitrypsin deficiency

    MedlinePLUS

    ... Where can I find information about diagnosis or management of alpha-1 antitrypsin deficiency? These resources address the diagnosis or management of alpha-1 antitrypsin deficiency and may include ...

  3. Evolution and seismology of alpha Centauri

    E-print Network

    Josefina Montalban; Andrea Miglio

    2005-09-15

    Solar-like oscillations detected in both components of the binary system alpha Centauri provide strong constraints on the fundamental parameters of the stellar system. We model alpha Centauri by means of a Levenberg-Marquardt minimization algorithm including seismic and classical constraints. Computations, that were perfomed decreasing significanly the weight of alpha Cen B seismic data in the calibration procedure, predict small separations in good agreement with new observations of solar-like oscillations in alpha Cen B by Bedding (these proceedings).

  4. Association of actin with alpha crystallins

    NASA Technical Reports Server (NTRS)

    Gopalakrishnan, S.; Boyle, D.; Takemoto, L.; Spooner, B. S. (Principal Investigator)

    1993-01-01

    The alpha crystallins are cytosolic proteins that co-localize and co-purify with actin-containing microfilaments. Affinity column chromatography employing both covalently-coupled actin or alpha crystallin was used to demonstrate specific and saturable binding of actin with alpha crystallin. This conclusion was confirmed by direct visualization of alpha aggregates bound to actin polymerized in vitro. The significance of this interaction in relation to the functional properties of these two polypeptides will be discussed.

  5. Classification of DES15S2myz and DES15S2mwz by GTC

    NASA Astrophysics Data System (ADS)

    Casas, R.; Castander, F. J.; Desai, S.; Paech, K.; Smith, R. C.; Schubnell, M.; Kessler, R.; Lasker, J.; Scolnic, D.; Brout, D. J.; Gladney, L.; Sako, M.; Wolf, R. C.; Brown, P. J.; Krisciunas, K.; Suntzeff, N.; Nichol, R.; Papadopoulos, A.; Childress, M.; D'Andrea, C.; Smith, M.; Sullivan, M.; Maartens, R.; Gupta, R.; Kovacs, E.; Kuhlmann, S.; Spinka, H.; Ahn, E.; Finley, D. A.; Frieman, J.; Marriner, J.; Wester, W.; Aldering, G.; Kim, A. G.; Thomas, R. C.; Barbary, K.; Bloom, J. S.; Goldstein, D.; Nugent, P.; Perlmutter, S.; Foley, R. J.; Pan, Y.-C.

    2015-12-01

    We report optical spectroscopy of DES15S2myz and DES15S2mwz discovered by the Dark Energy Survey (ATel #4668). The spectra (495-920nm) were obtained using OSIRIS on the Gran Telescopio CANARIAS (GTC).

  6. Traitement Automatique des Langues Naturelles, Marseille, 2014 Grammaire rcursive non linaire pour les langues des signes

    E-print Network

    linguistique. Par exemple, l'expression de relations spa les langues des signes, rendant compte de leurs particularités linguistiques. Comparable aux'analyse des liens entre formes produites/observées et fonctions linguistiques au sens large, on observe un

  7. Atypical Alpha Asymmetry in Adults with ADHD

    ERIC Educational Resources Information Center

    Hale, T. Sigi; Smalley, Susan L.; Hanada, Grant; Macion, James; McCracken, James T.; McGough, James J.; Loo, Sandra K.

    2009-01-01

    Introduction: A growing body of literature suggests atypical cerebral asymmetry and interhemispheric interaction in ADHD. A common means of assessing lateralized brain function in clinical populations has been to examine the relative proportion of EEG alpha activity (8-12 Hz) in each hemisphere (i.e., alpha asymmetry). Increased rightward alpha

  8. Recent Results on the CKM Angle Alpha

    SciTech Connect

    Mihalyi, A.; /Wisconsin U., Madison

    2005-10-18

    The method to measure the CKM angle {alpha} and the modes sensitive to it are discussed. It is shown that the B {yields} {rho}{rho} decays provide the most stringent constraint on {alpha}, which is found to be {alpha} = 96{sup o} {+-} 10{sup o}(stat) {+-} 4{sup o}(syst){+-} 13{sup o}(penguin).

  9. Evaluation des connaissances des parents sur les bronchiolites aiguës

    PubMed Central

    Gueddari, Widad; Tazi, Abderrahmane; Ouardi, Amine; Nani, Samira; Zineddine, Abdelhadi

    2014-01-01

    Les infections respiratoires (IR) constituent la deuxième cause de mortalité infantile au Maroc, dû en partie à l'absence d'information et de sensibilisation. Le but de ce travail était d’évaluer les connaissances des parents sur la bronchiolite aiguë, infection respiratoire très fréquente. Nous avons réalisé une enquête basée sur un questionnaire, auprès de parents de nourrissons consultants pour toux, avec ou sans gêne respiratoire. 180 parents ont été inclus dans l’étude. Les parents pensaient que l'infection respiratoire était secondaire au climat froid (96%); seuls 4% ont évoqué une origine infectieuse. Aucun des parents ne savait que le lavage des mains était un moyen de prévention de la transmission. Les parents ont majoritairement répondu que la kinésithérapie respiratoire ne servait à rien (65%), et qu'elle était nocive (24.5%). Ce manque de connaissances fondamentales en matière d'IR et de bronchiolite en particulier, devrait inciter à entreprendre un programme de sensibilisation PMID:25328606

  10. Caractérisation des convertisseurs matriciels : II. Synthèse des fonctions de connexion

    NASA Astrophysics Data System (ADS)

    François, B.; Cambronne, J. P.; Hautier, J. P.

    1996-05-01

    Knowing the wished conversion levels (-1,0,1) of a power converter, this paper describes a particular method for setting the corresponding states of switches into the matrix converter. In a first step, a mathematical analysis establishes the relations linking the states of switches with the conversion functions. Afterwards, the presented method gives the inverse relations which constitute the sequential part of the converter control. The turn-on and the turn-off sequences are designed by considering the on-line wished level conversions. This general method enhances the idea that a converter functionnality must be defined by its structure and its control. Cet article propose une méthode originale pour définir la séquence de commande d'un convertisseur à partir de la fonction de conversion globalement souhaitée. Les auteurs procèdent d'abord à une analyse mathématique précise des relations qui existent entre les états des interrupteurs et les fonctions de conversion obtenues. À partir de cette analyse, la méthode developpée permet d'établir systématiquement les relations inverses qui constituent alors le module séquentiel de la commande rapprochée du convertisseur. Les ordres d'ouverture et de fermeture des interrupteurs sont élaborés en considérant à tout instant les niveaux de conversion souhaités pour les grandeurs électriques. Cette méthode générale renforce l'idée que la fonction remplie par un convertisseur moderne doit être définie à la fois par sa structure et sa commande.

  11. Direction des Ressources Humaines Contacts Bureau des concours Ple GPEEC / Bureau des Concours nicole.berkowitz@univ-amu.fr

    E-print Network

    Avignon et des Pays de Vaucluse, Université de

    (titulaires, non titulaires, contrats étudiants). Positionnement hiérarchique : sous l'autorité du responsable administratif. COMPETENCES REQUISES : Connaissances générales et intérêt pour la gestion des ressources humaines

  12. Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume

    ERIC Educational Resources Information Center

    Edgar, J. Christopher; Heiken, Kory; Chen, Yu-Han; Herrington, John D.; Chow, Vivian; Liu, Song; Bloy, Luke; Huang, Mingxiong; Pandey, Juhi; Cannon, Katelyn M.; Qasmieh, Saba; Levy, Susan E.; Schultz, Robert T.; Roberts, Timothy P. L.

    2015-01-01

    Alpha circuits (8-12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha

  13. Les applications des faisceaux d'ions dans la physique des polymères

    NASA Astrophysics Data System (ADS)

    Ratier, B.; Moliton, A.; Lucas, B.; Guille, B.; Clamadieu, M.

    1998-06-01

    Experimental configurations of ions beams are illustrated by diagrams in the case of low energy implantation, Reactive Ion Beam Etching (RIBE), Ion Beam Assisted Deposition (IBAD) of molecular layers (or oligomers). Nous présentons les configurations expérimentales (illustrées par des schémas) de trois applications des faisceaux d'ions au traitement physique des polymères : dopage par implantation (cité pour mémoire), gravure par faisceaux d'ions réactifs (RIBE), dépôt des couches moléculaires (ou oligomères) assistés par faisceau (IBAD).

  14. M2 OASC : Fiche de stage Titre du stage : Apport d'une simulation haute rsolution pour la description des tourbillons en mer des

    E-print Network

    description des tourbillons en mer des Salomon Nom et statut du (des) responsable (s) de stage : Gourdeau Sujet du stage : La mer des Salomon située dans le Pacifique sud ouest est le lieu de transit des courants de bord ouest lors de leur traversée de la mer des Salomon sont soumis à des contraintes

  15. Partager : des technologies de pointe au service de la société

    ScienceCinema

    None

    2011-10-06

    Médecine, climatologie, métrologie et informatique, les techniques utilisées par le LHC trouvent déjà des répercussions dans d?autres domaines scientifiques. Utilisant des techniques inédites, la physique des particules en fait bénéficier la société toute entière.

  16. Werkzeuge der Informatik Grundlagen und Werkzeuge des WWW (Teil 1)

    E-print Network

    Zachmann, Gabriel

    . Müller, 2011 Geschichte des WWW · Anfänge des WWW Geschichte des Internet · 1980: Tim Berners-Lee (CERN) schreibt Programm "ENQUIRE", das es erlaubt, Knoten im Internet zu verlinken · 1989: Tim Berners-Lee: CERN

  17. Universit Paris XIII Mmoire d'Habilitation Diriger des Recherches

    E-print Network

    Poinsot, Laurent

    Université Paris XIII Mémoire d'Habilitation à Diriger des Recherches Spécialités : Mathématiques Mathématiques, EA 4535 Claude Carlet Professeur des Universités, Université Paris VIII Vincennes. Duchamp Professeur des Universités, Université Paris XIII, Rapporteur Laboratoire d'Informatique de Paris

  18. Devenir des diplms Promotion 2011-2012

    E-print Network

    Sart, Remi

    de l'enquête. 64,6% occupent des fonctions cadres. Le salaire net mensuel moyen est de 1726 . Photo(s):©JérômePALL�-UniversitéBlaisePascal leur diplôme. Concernant les Masters de l'Université Blaise Pascal, sur les 1136 diplômés de la des diplômés de Master de l'Université Blaise Pascal, toutes formations confondues. > > Sommaire des

  19. Brassinolide activities of 2alpha,3alpha-diols versus 3alpha,4alpha-diols in the bean second internode bioassay: explanation by molecular modeling methods.

    PubMed

    Sísa, Miroslav; Vilaplana-Polo, Marc; Ballesteros, Carme Brosa; Kohout, Ladislav

    2007-10-01

    In general, the structural requirements postulated for a high brassinolide activity are: 2alpha,3alpha-diol, 6-ketone or better 7-oxalactone in B-ring, A/B trans fused ring junction, a cis C-22,C-23-diol preferentially with RR configurations, and a C-24 methyl or ethyl substituent [Takatsuto S, Yazawa N, Ikekawa N, Takematsu T, Takeuchi Y, Koguchi M. Structure-activity relationship of brassinosteroids. Phytochemistry 1983;22:2437-41; Thompson MJ, Meudt WJ, Mandava NB, Dutky SR, Lusby WR, Spaulding DW. Synthesis of brassinosteroids and relationship of structure to plant growth-promoting effects. Steroids 1982;39:89-105]. We found that the 3alpha,4alpha-diols 4, 6 and 8 are more active than the 2alpha,3alpha-diols 3, 5 and 7 [Sísa M, Budesínský M, Kohout L. Synthesis of 7a-homo and 7a,7b-dihomo-5alpha-cholestane analogues of brassinolide. Collect Czech Chem Commun 2003;68:2171-89]. This fact is in strong contrast with the structure requirements mentioned above. Our hypothesis suggests that the lower activity of 2alpha,3alpha-diols and/or the higher activity of 3alpha,4alpha-diols could be explained by twisting and distortion of the molecule due to the seven- or eight-membered B-ring and also by the position of a carbonyl group relative to the A-ring diol. 3D-SAR computer methodologies as alignments and overlaps of GRID maps and 3D-QSAR analysis GRID-GOLPE (CoMFA-like) were used as an effort to explain the higher bioactivity of 3alpha,4alpha-diols 4, 6 and 8 in comparison with the 2alpha,3alpha-diols 3, 5 and 7 of B-ring enlarged brassinosteroids. PMID:17719069

  20. Etude des Seuils de Poursuite et de Dmodulation des Signaux Galileo pour

    E-print Network

    Dobigeon, Nicolas

    Etude des Seuils de Poursuite et de Démodulation des Signaux Galileo pour l'Aviation Civile Lieu'utilisation de Galileo par l'aviation civile. D'autre part, dans le cadre de discussions bilatérales entre les signaux GPS et Galileo, et, en particulier, afin de s'assurer que la co-existence des signaux GPS et

  1. Profil épidemio-clinique et radiologique des atteintes ostéo-articulaires des hémophiles à Madagascar

    PubMed Central

    Narindra, Lova Hasina Rajaonarison Ny Ony; Rabemanorintsoa, Feno Hasina; Randrianantenaina, Faralahy Ravelonarivo; Rakoto, Olivat Alson Aimée; Ahmad, Ahmad

    2014-01-01

    Introduction Déterminer le profil épidémio-clinique et radiologique des atteintes ostéo-articulaires des hémophiles malagasy. Méthodes Une étude prospective, descriptive portant sur 25 patients hémophiles venant de tout Madagascar a été réalisée. Des radiographies numérisées des genoux, des chevilles et des coudes en incidence de face et de profil ainsi qu'une échographie des hanches, des genoux, des chevilles et des coudes ont été réalisées chez ces patients. Le type et la sévérité de la maladie ainsi que l'aspect de la cavité articulaire, la synoviale, les noyaux épiphysaires et les surfaces articulaires ont été analysés. Résultats Soixante-huit pourcent des patients étaient hémophiles de type A et 32 % de type B. Quarante pourcent étaient classés sévères, 28 % modérés et 32 % mineurs. Les atteintes ostéo-articulaires ont été retrouvées chez 56 % des patients. Il n'existait pas de prédominance d'atteinte selon le type ni la sévérité de la maladie. Les plus jeunes étaient les plus atteints et l'articulation du genou et de la cheville étaient les plus touchées. Conclusion Les complications ostéo-articulaire de l'hémophilie sont graves et ne dépendent pas du type ni de la sévérité de l'affection. Elles touchent surtout les enfants d'âge scolaire. Le couple radiographie-échographie permet de diagnostiquer et de surveiller ces lésions. PMID:25870742

  2. Aide aux doctorants pour la participation des Aide aux doctorants pour la participation des colloques

    E-print Network

    Di Girolami, Cristina

    Aide aux doctorants pour la participation à des colloques Aide aux doctorants pour la participation à des colloques retour Formation doctorale Aide aux doctorants pour la participation à des colloques aide vient compléter les financements déjà prévus par les laboratoires et les Écoles doctorales pour

  3. THE LYMAN ALPHA REFERENCE SAMPLE: EXTENDED LYMAN ALPHA HALOS PRODUCED AT LOW DUST CONTENT

    SciTech Connect

    Hayes, Matthew; Oestlin, Goeran; Duval, Florent; Guaita, Lucia; Melinder, Jens; Sandberg, Andreas; Schaerer, Daniel; Verhamme, Anne; Orlitova, Ivana; Mas-Hesse, J. Miguel; Oti-Floranes, Hector; Adamo, Angela; Atek, Hakim; Cannon, John M.; Herenz, E. Christian; Kunth, Daniel; Laursen, Peter

    2013-03-10

    We report on new imaging observations of the Lyman alpha emission line (Ly{alpha}), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028 < z < 0.18 in continuum-subtracted Ly{alpha}, H{alpha}, and the far ultraviolet continuum. We show that Ly{alpha} is emitted on scales that systematically exceed those of the massive stellar population and recombination nebulae: as measured by the Petrosian 20% radius, R{sub P20}, Ly{alpha} radii are larger than those of H{alpha} by factors ranging from 1 to 3.6, with an average of 2.4. The average ratio of Ly{alpha}-to-FUV radii is 2.9. This suggests that much of the Ly{alpha} light is pushed to large radii by resonance scattering. Defining the Relative Petrosian Extension of Ly{alpha} compared to H{alpha}, {xi}{sub Ly{alpha}} = R {sup Ly{alpha}}{sub P20}/R {sup H{alpha}}{sub P20}, we find {xi}{sub Ly{alpha}} to be uncorrelated with total Ly{alpha} luminosity. However, {xi}{sub Ly{alpha}} is strongly correlated with quantities that scale with dust content, in the sense that a low dust abundance is a necessary requirement (although not the only one) in order to spread Ly{alpha} photons throughout the interstellar medium and drive a large extended Ly{alpha} halo.

  4. Innovations in Los Alamos alpha box design

    SciTech Connect

    Ledbetter, J.M.; Dowler, K.E.; Cook, J.H.

    1985-01-01

    Destructive examinations of irradiated fuel pins containing plutonium fuel must be performed in shielded hot cells with strict provisions for containing the plutonium. Alpha boxes provide containment for the plutonium, toxic fission products, and other hazardous highly radioactive materials. The alpha box contains windows for viewing and a variety of transfer systems specially designed to allow transfers in and out of the alpha box without spread of the hazardous materials that are contained in the box. Alpha boxes have been in use in the Wing 9 hot cells at Los Alamos National Laboratory for more than 20 years. Features of the newly designed alpha boxes are presented.

  5. Alpha voltaic batteries and methods thereof

    NASA Technical Reports Server (NTRS)

    Raffaelle, Ryne P. (Inventor); Jenkins, Phillip (Inventor); Wilt, David (Inventor); Scheiman, David (Inventor); Chubb, Donald (Inventor); Castro, Stephanie (Inventor)

    2011-01-01

    An alpha voltaic battery includes at least one layer of a semiconductor material comprising at least one p/n junction, at least one absorption and conversion layer on the at least one layer of semiconductor layer, and at least one alpha particle emitter. The absorption and conversion layer prevents at least a portion of alpha particles from the alpha particle emitter from damaging the p/n junction in the layer of semiconductor material. The absorption and conversion layer also converts at least a portion of energy from the alpha particles into electron-hole pairs for collection by the one p/n junction in the layer of semiconductor material.

  6. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.

    PubMed Central

    Offermanns, S; Zhao, L P; Gohla, A; Sarosi, I; Simon, M I; Wilkie, T M

    1998-01-01

    Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact allele [G alpha q(-/+);G alpha 11(-/-) or G alpha q(-/-);G alpha 11(-/+)] died shortly after birth. These mutants showed a high incidence of cardiac malformation. In addition, G alpha q(-/-);G alpha 11(-/+) newborns suffered from craniofacial defects. Mice lacking both G alpha q and G alpha 11 [G alpha q(-/-);G alpha 11(-/-)] died at embryonic day 11 due to cardiomyocyte hypoplasia. These data demonstrate overlap in G alpha q and G alpha 11 gene functions and indicate that the Gq class of G proteins plays a crucial role in cardiac growth and development. PMID:9687499

  7. Physiologic and prognostic significance of "alpha coma".

    PubMed Central

    Iragui, V J; McCutchen, C B

    1983-01-01

    A patient with posthypoxic "alpha coma" is described whose EEGs were recorded before coma, within two hours following the onset of coma and after recovery. The differences observed between the alpha activity during coma and that seen before and after suggest that the alpha activity during coma and the physiologic alpha rhythm are different phenomena. This case, as well as others reported, also suggests that "alpha coma" resolving in the first 24 hours following hypoxia may have a better prognosis than "alpha coma" detected after the first day, and stresses the need for EEG monitoring begun in the immediate period following hypoxia in order to assess accurately the prognostic significance of this EEG pattern in the early stages of postanoxic encephalopathy. The aetiology of "alpha coma" also affects outcome. The survival rate appears higher in patients with respiratory arrest than in those with combined cardiopulmonary arrest. PMID:6886700

  8. Relation entre les caractéristiques des table-bancs et les mesures anthropométriques des écoliers au Benin

    PubMed Central

    Falola, Stève Marjelin; Gouthon, Polycarpe; Falola, Jean-Marie; Fiogbe, Michel Armand; Nigan, Issiako Bio

    2014-01-01

    Introduction Le mobilier scolaire et la posture assise en classe sont souvent impliqués dans l'apparition des douleurs rachidiennes, influant de fait sur la qualité des tâches réalisées par les apprenants. Aucune étude n'a encore vérifié le degré d'adéquation entre les caractéristiques du mobilier et celles des écoliers au Bénin. L'objectif de cette étude transversale est donc de déterminer la relation entre les dimensions des table-bancs utilisées en classe et les mesures anthropométriques des écoliers au Bénin. Methods Elle a été réalisée avec un échantillon probabiliste de 678 écoliers, âgés de 4 à 17 ans. Les mesures anthropométriques des écoliers et les mensurations relatives aux longueurs, largeurs et hauteurs des table-bancs ont été mesurées, puis intégrées aux équations proposées dans la littérature. Les pourcentages des valeurs situées hors des limitesacceptables, dérivées de l'application des équations ont été calculés. Results La largeur et la hauteur des table-bancs utilisées par les écoliers étaient plus élevées (p < 0,05) que les valeurs de référence recommandées par les structures officielles de contrôle et de production des mobiliers scolaires au Bénin. Quel que soit le sexe, il y avait une inadéquation entre la largeur du banc et la longueur fesse-poplité, puis entre la hauteur de la table et la distance coude-bancdes écoliers. Conclusion Les résultats suggèrent de prendre en compte l’évolution des mesures anthropométriques des écoliers dans la confection des table-bancs, afin de promouvoir de bonnes postures assises en classe et de réduire le risque de troubles du rachis. PMID:25317232

  9. Le traitement familial des enfants et des adolescents anorexiques : Des lignes directrices pour le médecin communautaire

    PubMed Central

    Findlay, S; Pinzon, J; Taddeo, D; Katzman, DK

    2010-01-01

    L’anorexie mentale (AM) est une maladie grave qui met la vie en danger et qui fait généralement son apparition pendant l’adolescence. Les données probantes au sujet du traitement optimal de l’AM chez les enfants et les adolescents sont en croissance, mais il reste beaucoup à apprendre. Même si les démarches thérapeutiques actuelles varient au Canada et ailleurs, les données jusqu’à présent indiquent que le traitement familial (TF) est le plus efficace pour les enfants et les adolescents anorexiques. Un élément essentiel du modèle de TF, c’est que les parents sont investis de la responsabilité de rétablir la santé physique de leur enfant et de s’assurer de la reprise complète de son poids. Le médecin qui comprend les principes fondamentaux et la philosophie du TF peut mettre en place les éléments de cette intervention fondée sur des faits probants auprès des jeunes patients anorexiques et de leur famille.

  10. Le dialecte natal: analyse de l’opinion des intellectuels et des villageois de Lituanie

    E-print Network

    Ka?iuškien?, Genovait?

    2010-02-01

    dialecte natal: analyse de l’opinion des intellectuels et des villageois de Lituanie Genovait? ka?iuškien? Université de Šiauliai, Faculté des sciences humaines, P. Višinskio 38, LT – 76352 Šiauliai, geno@splius.lt ?lanek temelji na izsledkih...–165 — 139 — Le dialecte natal: analyse de l’opinion des intellectuels et des villageois de Lituanie Le lituanien comporte deux grands groupes dialectaux : celui de l’ouest, la Basse-Lituanie ou Samogites (žemaitija), et celui de l’est, la Haute...

  11. Using XML to encode TMA DES metadata

    PubMed Central

    Lyttleton, Oliver; Wright, Alexander; Treanor, Darren; Lewis, Paul

    2011-01-01

    Background: The Tissue Microarray Data Exchange Specification (TMA DES) is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. Materials and Methods: We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. Results: We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. Conclusions: All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs. PMID:21969921

  12. The Ly-alpha/H-alpha ratio in high-redshift radio galaxies

    NASA Technical Reports Server (NTRS)

    Mccarthy, Patrick J.; Elston, Richard; Eisenhardt, Peter

    1992-01-01

    The first spectroscopic detection of H-alpha emission from radio galaxies at z greater than 2 are presented. Strong H-alpha emission is detected at z = 2.429 in B3 0731 + 438, and H-alpha is directed at z = 2.428 in 0406 - 244 at a significant level of greater than 6 sigma. The resulting Ly-alpha/H-alpha ratios for 0731 + 438 and 0406 - 244 are 3.9 and 3.2 with 3 sigma uncertainties of 1.5 for each. A range of possible extinctions is derived depending on the reddening-free Ly-alpha/H-alpha ratio assumed and the extinction curve employed. The most important result of this study is the demonstration that the Ly-alpha/H-alpha ratio in distant galaxies can now be measured with relative ease.

  13. Synthesis of 16 alpha-3H androgen and estrogen substrates for 16 alpha-hydroxylase.

    PubMed

    Cantineau, R; Kremers, P; De Graeve, J; Cornelis, A; Laszlo, P; Gielen, J E; Lambotte, R

    1981-02-01

    The synthesis of 16 alpha-3H androgens and estrogens is described. 1-(3H)-Acetic acid in the presence of zinc dust reacts with 16 alpha-bromo-17-ketosteroids to produce 16 alpha-3H-17-ketosteroids. This chemical reaction was used to prepare 16 alpha-3H-dehydroepiandrosterone (I) and 16 alpha-3H-estrone acetate (XI) from 16 alpha-bromo-dehydroepiandrosterone (X) and from 16 alpha-bromo-estrone acetate (XII), respectively. Using appropriate microbiological techniques, it was possible to convert these radiolabelled substrates into 16 alpha-3H-androstenedione (II) and 16 alpha-3H-estradiol-17 beta (VII). 16 alpha-3H-Estrone (VI) was obtained by the chemical hydrolysis of 16 alpha-3H-estrone acetate. The label distribution as determined by microbiological 16 alpha-hydroxylations indicated a specific labelling of 77% for androgens and 65% for estrogens in the 16 alpha position. These substrates can be used for measuring the 16 alpha hydroxylase activity, an important step in the biosynthesis of estriol (VIII) and estetrol (IX). PMID:7013160

  14. Agénésie bilatérale des vésicules séminales et des canaux déférents

    PubMed Central

    Kassogué, Amadou; El Ammari, J. Eddine; Diarra, Alkadri; Amiroune, Driss; Ahsaini, Mustapha; Ouldim, Karim; Traoré, Zacharia; Sqalli, H. Nadia; Tizniti, Siham; Mellas, Soufiane; Tazi, M. Fadl; Khallouk, Abdelhak; El Fassi, M. Jamal; Farih, My Hassan

    2014-01-01

    Résumé L’absence de canaux déférents et de vésicules séminales est une cause très rare d’infertilité masculine qui pose des difficultés d’ordre diagnostique. De plus, son traitement est complexe. Dans le présent article, nous rapportons le cas d’un patient âgé de 43 ans qui a consulté pour infertilité primaire évoluant depuis 5 ans (un conseil génétique a été réalisé) et nous examinons les difficultés diagnostiques et thérapeutiques liées à cette forme particulière d’infertilité. PMID:25132895

  15. Recoil-alpha-fission and recoil-alpha-alpha-fission events observed in the reaction Ca-48 + Am-243

    E-print Network

    U. Forsberg; D. Rudolph; L. -L. Andersson; A. Di Nitto; Ch. E. Düllmann; J. M. Gates; P. Golubev; K. E. Gregorich; C. J. Gross; R. -D. Herzberg; F. P. Hessberger; J. Khuyagbaatar; J. V. Kratz; K. Rykaczewski; L. G. Sarmiento; M. Schädel; A. Yakushev; S. Åberg; D. Ackermann; M. Block; H. Brand; B. G. Carlsson; D. Cox; X. Derkx; J. Dobaczewski; K. Eberhardt; J. Even; C. Fahlander; J. Gerl; E. Jäger; B. Kindler; J. Krier; I. Kojouharov; N. Kurz; B. Lommel; A. Mistry; C. Mokry; W. Nazarewicz; H. Nitsche; J. P. Omtvedt; P. Papadakis; I. Ragnarsson; J. Runke; H. Schaffner; B. Schausten; Y. Shi; P. Thörle-Pospiech; T. Torres; T. Traut; N. Trautmann; A. Türler; A. Ward; D. E. Ward; N. Wiehl

    2015-02-10

    Products of the fusion-evaporation reaction Ca-48 + Am-243 were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum f\\"ur Schwerionenforschung. Amongst the detected thirty correlated alpha-decay chains associated with the production of element Z=115, two recoil-alpha-fission and five recoil-alpha-alpha-fission events were observed. The latter are similar to four such events reported from experiments performed at the Dubna gas-filled separator. Contrary to their interpretation, we propose an alternative view, namely to assign eight of these eleven decay chains of recoil-alpha(-alpha)-fission type to start from the 3n-evaporation channel 115-288. The other three decay chains remain viable candidates for the 2n-evaporation channel 115-289.

  16. Recoil-alpha-fission and recoil-alpha-alpha-fission events observed in the reaction Ca-48 + Am-243

    E-print Network

    Forsberg, U; Andersson, L -L; Di Nitto, A; Düllmann, Ch E; Gates, J M; Golubev, P; Gregorich, K E; Gross, C J; Herzberg, R -D; Hessberger, F P; Khuyagbaatar, J; Kratz, J V; Rykaczewski, K; Sarmiento, L G; Schädel, M; Yakushev, A; Åberg, S; Ackermann, D; Block, M; Brand, H; Carlsson, B G; Cox, D; Derkx, X; Dobaczewski, J; Eberhardt, K; Even, J; Fahlander, C; Gerl, J; Jäger, E; Kindler, B; Krier, J; Kojouharov, I; Kurz, N; Lommel, B; Mistry, A; Mokry, C; Nazarewicz, W; Nitsche, H; Omtvedt, J P; Papadakis, P; Ragnarsson, I; Runke, J; Schaffner, H; Schausten, B; Shi, Y; Thörle-Pospiech, P; Torres, T; Traut, T; Trautmann, N; Türler, A; Ward, A; Ward, D E; Wiehl, N

    2015-01-01

    Products of the fusion-evaporation reaction Ca-48 + Am-243 were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum f\\"ur Schwerionenforschung. Amongst the detected thirty correlated alpha-decay chains associated with the production of element Z=115, two recoil-alpha-fission and five recoil-alpha-alpha-fission events were observed. The latter are similar to four such events reported from experiments performed at the Dubna gas-filled separator. Contrary to their interpretation, we propose an alternative view, namely to assign eight of these eleven decay chains of recoil-alpha(-alpha)-fission type to start from the 3n-evaporation channel 115-288. The other three decay chains remain viable candidates for the 2n-evaporation channel 115-289.

  17. Primary structure of bovine alpha 2-antiplasmin.

    PubMed

    Christensen, S; Berglund, L; Sottrup-Jensen, L

    1994-05-01

    The primary structure of bovine alpha 2-antiplasmin (alpha 2AP) has been determined from cDNA and partial peptide sequencing. Mature bovine alpha 2AP contains 470 residues and is 6 residues longer than human alpha 2AP. Alignment of the two protein sequences show that 81% of their amino acid residues are identically located. Bovine alpha 2AP has 5 N-linked carbohydrate groups, of which four are found in human alpha 2AP (Asn105, 274, 288 and 295). Asn227 is the fifth carbohydrate attachement site in bovine alpha 2AP. The 3 Cys residues of bovine alpha 2AP are present as an unpaired residue (Cys131) and as a pair in a disulfide bridge (Cys49-Cys122). The assignment of the bridge in bovine alpha 2AP is at variance with the previous assignment of the two disulfide bridges in human alpha 2AP [Lijnen, H.R. et al. (1987) Eur. J. Biochem. 166, 565-574]. PMID:7513654

  18. The solar Ly-alpha line profile

    NASA Technical Reports Server (NTRS)

    Woods, Thomas N.; Rottman, Gary J.; White, O. R.; Fontenla, Juan; Avrett, E. H.

    1995-01-01

    Solar Ly-alpha irradiance measurements from the SOLar STellar Irradiance Comparison Experiment (SOLSTICE) on the Upper Atmosphere Research Satellite (UARS) have been made since 1991 October with a spectral resolution of 0.1 nm. The uniqueness of the small molecular oxygen cross section near Ly-alpha permits the Ly-alpha radiation to penetrate much deeper into the atmosphere than the other emissions near Ly-alpha. We have taken advantage of this phenomenon by performing solar occultation experiments near the Ly-alpha to evaluate precisely the instrument scattered light contribution. After correcting for scattered light, the broad wings of the solar Ly-alpha line can be extracted out to 5 nm from line center with a typical accuracy of +/-20%. The variability in the Ly-alpha wings near 2 nm from line center is about one-half that of the Ly-alpha core emission, defined within 0.1 nm from line center. These Ly-alpha profile measurements are found to be consistent with the Skylab radiance measurements and theoretical models of the Ly-alpha line profiles computed using partial redistribution of photons in the source function.

  19. Atypical alpha asymmetry in adults with ADHD*

    PubMed Central

    Hale, T. Sigi; Smalley, Susan L.; Hanada, Grant; Macion, James; McCracken, James T.; McGough, James J.; Loo, Sandra K.

    2009-01-01

    Introduction A growing body of literature suggests atypical cerebral asymmetry and interhemispheric interaction in ADHD. A common means of assessing lateralized brain function in clinical populations has been to examine the relative proportion of EEG alpha activity (8– 12 Hz) in each hemisphere (i.e., alpha asymmetry). Increased rightward alpha asymmetry has been associated with ADHD-like traits such as reduced reward responsiveness, a lack of inhibition toward aversive experience, and increased approach behaviors, and previous work has indicated increased rightward alpha asymmetry in children with ADHD. The current study explores whether increased rightward alpha asymmetry is also evident in adults with ADHD. Method We assessed low (8– 10 Hz) and high (10– 12 Hz) alpha asymmetry in adults with ADHD (n = 29) versus controls (n = 62) during baseline and cognitive activation conditions for nine homologous electrode pairs along the anterior–posterior axis. Result Seven results emerged (p < .05) showing increased rightward alpha asymmetry in adults with ADHD. This occurred in three specific electrode pairs across two testing conditions, and five of six results occurred in the lower alpha band. Finally, post hoc analysis indicated that increased rightward alpha asymmetry was generally associated with greater numbers of ADHD symptoms—with a possible parietal association for inattentive and a fronto-temporal association for hyperactivity symptoms. Conclusions Increased rightward alpha asymmetry previously observed in children with ADHD appears to be a developmentally persistent feature of ADHD. PMID:19467358

  20. alpha,alpha-Difluoro-beta-aminodeoxystatine-containing renin inhibitory peptides.

    PubMed

    Thaisrivongs, S; Schostarez, H J; Pals, D T; Turner, S R

    1987-10-01

    The preparations of sodium 4(S)-[(tert-butyloxycarbonyl)amino]-2,2-difluoro-3(S)- and -3(R)-[(4-methoxyphenyl)amino]-6-methylheptanoates (7a and 7b) from sodium 4(S)-[(tert-butyloxycarbonyl)amino]-2,2-difluoro-3(R)- and -3(S)-hydroxy-6-methylheptanoates (1a and 1b) are described. The key step involves the stereospecific intramolecular displacement via a Mitsunobu reaction for the conversion of a beta-hydroxy hydroxamate to a beta-lactam ring. Compounds 7a and 7b are useful as synthetic intermediates for the preparation of enzyme inhibitors that contain 3(S),4(S)- and 3(R),4(S)-diamino-2,2-difluoro-6-methylheptanoic acid inserts. Angiotensinogen analogues VII and VIII that contain these novel amino analogues of difluorostatine were shown to be inhibitors of the enzyme renin. The alpha,alpha-difluoro-beta-aminodeoxystatine-containing compounds were shown to be weaker inhibitors than the corresponding difluorostatine-containing congeners. PMID:3309315

  1. Dies academicus 2012 Bericht des Rektors

    E-print Network

    Zürich, Universität

    Dies academicus 2012 Bericht des Rektors Wie es bereits zur Tradition geworden ist, nehme ich Sie Glanzlichtern des vergangenen Jahres zählte. Zum ersten Mal organisierten die Universität Zürich und die ETH gemeinsam die Zürcher Wissenschaftstage und luden während eines ganzen Wochenendes zur Begegnung und zum

  2. DES Chapter 10 The Condensed Financial

    E-print Network

    Schubart, Christoph

    or Actual sheets. The spreadsheet automatically condenses the Comprehensive sheet into a format called theComprehensive sheet into a format called the Condensed sheet. See DES Chapter 10 and its Appendix (continued) DES (Gerichtsverfahren), casualty losses due to flood, fire, or tornado, and gains or l th ti i h t (Ablö ) f d btlosses

  3. Copernic: la piste des influences arabes

    NASA Astrophysics Data System (ADS)

    Khalatbari, A.; Bonnet-Bidaud, J. M.

    2004-10-01

    Copernic a-t-il connu le travail des astronomes du Moyen-Orient ? S'en est-il inspiré pour élaborer sa théorie de l'héliocentrisme ? C'est l'hypothèse avancée par certains historiens des sciences pour comprendre le génie de celui qui, le premier, a placé le Soleil au centre du monde. Enquête.

  4. JOSEPH LOUIS LAGRANGE, THORIE DES FONCTIONS ANALYTIQUES,

    E-print Network

    Fraser, Craig

    CHAPTER 19 JOSEPH LOUIS LAGRANGE, TH�ORIE DES FONCTIONS ANALYTIQUES, FIRST EDITION (1797) Craig G (§25). 1 INTRODUCTION At the end of the 18th century Joseph Louis Lagrange (1736­1813) published a book Elsevier B.V. All rights reserved. 258 #12;Chapter 19. Joseph Louis Lagrange, Théorie des fonctions

  5. Facult des sciences de l'agriculture

    E-print Network

    Laval, Université

    #12;Faculté des sciences de l'agriculture et de l'alimentation Rapport annuel des activités de'agriculture et de l'alimentation Vice-décanat à la recherche Madame, Monsieur, En 2007-2008, la Faculté de sciences de l'agriculture et de l'alimentation a connu une autre très bonne année quant au financement de

  6. Facult des sciences de l'agriculture

    E-print Network

    Laval, Université

    Faculté des sciences de l'agriculture et de l'alimentation Rapport annuel des activités de'agriculture et de l'alimentation Vice-décanat à la recherche Madame, Monsieur, C'est avec un plaisir renouvelé'agriculture et de l'alimentation (FSAA). Encore une fois, les chercheurs de la FSAA ont su démontrer une

  7. Quelques tendances actuelles en histoire des mathematiques.

    E-print Network

    Aubin, David

    Development, sous la dir. de Joseph W. Dauben et Christoph J. Scriba, Birkh¨auser, B^ale, 2002, p. 6. 3 Voir Catherine Goldstein, Jeremy Gray et Jim Ritter, dir., L'Europe math´ematique : histoire, mythes, identit´ematiques `a des ´epoques et dans des cultures diff´erentes. Dans un ouvrage r´ecent dirig´e par Joseph Dauben

  8. Gestion durable des ressources en agriculture

    E-print Network

    Sart, Remi

    Gestion durable des ressources en agriculture Mention : Agronomie Nature de la formation : Diplôme durable des ressources en agriculture UFR Sciences et Technologies PRÉSENTATION Objectifs La Licence diplôme sera donc un technicien spécialisé à l'interface entre l'agriculture et l

  9. Targeted alpha therapy for cancer

    NASA Astrophysics Data System (ADS)

    Allen, Barry J.; Raja, Chand; Rizvi, Syed; Li, Yong; Tsui, Wendy; Zhang, David; Song, Emma; Qu, Chang Fa; Kearsley, John; Graham, Peter; Thompson, John

    2004-08-01

    Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT is tested by in vitro and in vivo studies in melanoma, leukaemia, colorectal, breast and prostate cancers, and by a phase 1 trial of intralesional TAT for melanoma. The alpha-emitting radioisotope used is Bi-213, which is eluted from the Ac-225 generator and chelated to a cancer specific monoclonal antibody (mab) or protein (e.g. plasminogen activator inhibitor-2 PAI2) to form the alpha-conjugate (AC). Stable alpha-ACs have been produced which have been tested for specificity and cytotoxicity in vitro against melanoma (9.2.27 mab), leukaemia (WM60), colorectal (C30.6), breast (PAI2, herceptin), ovarian (PAI2, herceptin, C595), prostate (PAI2, J591) and pancreatic (PAI2, C595) cancers. Subcutaneous inoculation of 1-1.5 million human cancer cells into the flanks of nude mice causes tumours to grow in all mice. Tumour growth is compared for untreated controls, nonspecific AC and specific AC, for local (subcutaneous) and systemic (tail vein or intraperitoneal) injection models. The 213Bi-9.2.27 AC is injected into secondary skin melanomas in stage 4 patients in a dose escalation study to determine the effective tolerance dose, and to measure kinematics to obtain the equivalent dose to organs. In vitro studies show that TAT is one to two orders of magnitude more cytotoxic to targeted cells than non-specific ACs, specific beta emitting conjugates or free isotopes. In vivo local TAT at 2 days post-inoculation completely prevents tumour formation for all cancers tested so far. Intra-lesional TAT can completely regress advanced sc melanoma but is less successful for breast and prostate cancers. Systemic TAT inhibits the growth of sc melanoma xenografts and gives almost complete control of breast and prostate cancer tumour growth. Intralesional doses up to 450 µCi in human patients are effective in regressing melanomas, with no concomitant complications. These results point to the application of local and systemic TAT in the management of secondary cancer. Results of the phase 1 clinical trial of TAT of subcutaneous, secondary melanoma indicate proof of the principle that TAT can make tumours in patients regress.

  10. High gas flow alpha detector

    DOEpatents

    Bolton, Richard D. (Los Alamos, NM); Bounds, John A. (Los Alamos, NM); Rawool-Sullivan, Mohini W. (Los Alamos, NM)

    1996-01-01

    An alpha detector for application in areas of high velocity gas flows, such as smokestacks and air vents. A plurality of spaced apart signal collectors are placed inside an enclosure, which would include smokestacks and air vents, in sufficient numbers to substantially span said enclosure so that gas ions generated within the gas flow are electrostatically captured by the signal collector means. Electrometer means and a voltage source are connected to the signal collectors to generate an electrical field between adjacent signal collectors, and to indicate a current produced through collection of the gas ions by the signal collectors.

  11. Alpha Channeling in Mirror Machines

    SciTech Connect

    Fisch, N. J.

    2006-12-01

    The injection of radio frequency waves can cool charged particles trapped in a magnetic mirror. This cooling effect relies upon waves with azimuthal and axial phase velocities resonating with ions in different axial locations. The ions are then forced to diffuse along highly constrained orbits, such that they can only exit the magnetic trap at low energy. This cooling effect may have application to magnetic fusion mirror machines, where the free energy of the fusion by-products, the {alpha} particles, might be channeled into the waves that effect the cooling, thereby both extracting the fusion ash quickly and making that energy available in a convenient form for more useful purposes.

  12. Alpha channeling in mirror machines.

    PubMed

    Fisch, N J

    2006-12-01

    The injection of radio frequency waves can cool charged particles trapped in a magnetic mirror. This cooling effect relies upon waves with azimuthal and axial phase velocities resonating with ions in different axial locations. The ions are then forced to diffuse along highly constrained orbits, such that they can only exit the magnetic trap at low energy. This cooling effect may have application to magnetic fusion mirror machines, where the free energy of the fusion by-products, the alpha particles, might be channeled into the waves that effect the cooling, thereby both extracting the fusion ash quickly and making that energy available in a convenient form for more useful purposes. PMID:17155807

  13. High gas flow alpha detector

    DOEpatents

    Bolton, R.D.; Bounds, J.A.; Rawool-Sullivan, M.W.

    1996-05-07

    An alpha detector for application in areas of high velocity gas flows, such as smokestacks and air vents. A plurality of spaced apart signal collectors are placed inside an enclosure, which would include smokestacks and air vents, in sufficient numbers to substantially span said enclosure so that gas ions generated within the gas flow are electrostatically captured by the signal collector means. Electrometer means and a voltage source are connected to the signal collectors to generate an electrical field between adjacent signal collectors, and to indicate a current produced through collection of the gas ions by the signal collectors. 4 figs.

  14. Les implications du phénomène des médecins hospitaliers

    PubMed Central

    Lehmann, François; Brunelle, Yvon; Dawes, Martin; Boulé, Richard; Bergeron, Rénald

    2007-01-01

    RÉSUMÉ OBJECTIF Évaluer l’impact de 2 systèmes de soins hospitaliers par une revue de la littérature. QUALITÉ DES DONNÉES Il reste des zones nébuleuses car plusieurs des études sont opportunistes, signalant une expérience isolée ou de simples avant-après. Peu sont vraiment expérimentales et toutes ont été menées dans des milieux universitaires, limitant ainsi leur validité externe. MESSAGE PRINCIPAL Les données supportent l’utilisation de médecins hospitaliers qui consacrent un minimum de 2 mois par année à ce travail et qui sont alors à plein temps sur les étages. Les coûts sont plus souvent qu’autrement réduits et l’enseignement est amélioré. Point de repère important de la qualité des soins, la mortalité est égale dans les 2 systèmes de soins. CONCLUSION Certaines questions demeurent sans réponse dont le choix de la meilleure formation en vue de préparer les résidents au travail hospitalier et la façon de maintenir les compétences acquises. PMID:18077751

  15. Lorentz Violation and Alpha-Decay

    E-print Network

    Brett Altschul

    2008-12-11

    Relating the effective Lorentz violation coefficients for composite particles to the coefficients for their constituent fields is a challenging problem. We calculate the Lorentz violation coefficients relevant to the dynamics of an alpha-particle in terms of proton and neutron coefficients. The alpha-particle coefficients would lead to anisotropies in the alpha-decays of nuclei, and because the decay process involves quantum tunneling, the effects of any Lorentz violations could be exponentially enhanced.

  16. Beta/alpha continuous air monitor

    DOEpatents

    Becker, G.K.; Martz, D.E.

    1988-06-27

    A single deep layer silicon detector in combination with a microcomputer, recording both alpha and beta activity and the energy of each pulse, distinquishing energy peaks using a novel curve fitting technique to reduce the natural alpha counts in the energy region where plutonium and other transuranic alpha emitters are present, and using a novel algorithm to strip out radon daughter contribution to actual beta counts. 7 figs.

  17. Beta/alpha continuous air monitor

    SciTech Connect

    Becker, Gregory K.; Martz, Dowell E.

    1989-01-01

    A single deep layer silicon detector in combination with a microcomputer, recording both alpha and beta activity and the energy of each pulse, distinguishing energy peaks using a novel curve fitting technique to reduce the natural alpha counts in the energy region where plutonium and other transuranic alpha emitters are present, and using a novel algorithm to strip out radon daughter contribution to actual beta counts.

  18. Concepts of alpha-particle condensation

    E-print Network

    Y. Funaki; H. Horiuchi; W. von Oertzen; G. Roepke; P. Schuck; A. Tohsaki; T. Yamada

    2009-12-15

    Certain aspects of the recently proposed antisymmetrised alpha particle product state wave function, or THSR alpha cluster wave function, for the description of the ground state in 8Be, the Hoyle state in 12C, and analogous states in heavier nuclei, are elaborated in detail. For instance, the influence of antisymmetrisation in the Hoyle state on the bosonic character of the alpha particles is studied carefully. It is shown to be weak, so that bosonic aspects are predominant. The de Broglie wave length of alpha particles in the Hoyle state is shown to be much larger than the inter-alpha distance. It is pointed out that the bosonic features of low density alpha gas states have measurable consequences, one of which, that is enhanced multi-alpha decay properties, likely already have been detected. Consistent with experiment, the width of the proposed analogue to the Hoyle state in 16O at the excitation energy of E_x=15.1 MeV is estimated to be very small (34 keV), lending credit to the existence of heavier Hoyle-like states. The intrinsic single boson density matrix of a self-bound Bose system can, under physically desirable boundary conditions, be defined unambiguously. One eigenvalue then separates out, being close to the number of alpha's in the system. Differences between Brink and THSR alpha cluster wave functions are worked out. No cluster model of the Brink type can describe the Hoyle state with a single configuration. On the contrary, many superpositions of the Brink type are necessary, implying delocalisation towards an alpha product state. It is shown that single alpha particle orbits in condensates of different nuclei are almost the same. It is thus argued that alpha particle antisymmetrised product states of the THSR type are a very promising novel and useful concept in nuclear physics.

  19. APPEL DE COMMUNICATIONS la croise des chemins, les tudes sur

    E-print Network

    Farrell, Anthony P.

    APPEL DE COMMUNICATIONS À la croisée des chemins, les études sur l'alimentation : devant une bifurcation? SEPTIÈME ASSEMBLÉE GÉNÉRALE ANNUELLE DE L'ASSOCIATION CANADIENNE DES ÉTUDES SUR L'ALIMENTATION DU canadienne des sciences humaines, est « À la croisée des chemins, les études sur l'alimentation : devant une

  20. Vice-dcanat la recherche Rpertoire des projets

    E-print Network

    Laval, Université

    ........................................................................................................................ 18 Département des sciences des aliments et nutrition'agriculture, des pêcheries et de l'alimentation - 2008-05-08 au 2010-12-31 Réf. 91082 Chercheur(s) participant(s) # projet Montant Ministère de l'agriculture, des pêcheries et de l'alimentation GQ091082 DC 47 160

  1. Rapport annuel des activits de recherche 2008-2009

    E-print Network

    Laval, Université

    de l'alimentation Rapport annuel des activités de recherche 2008-2009 #12;#12;Page 3Rapport annuel des activités de recherche Faculté des sciences de l'agriculture et de l'alimentation Vice-décanat à la recherche Madame, Monsieur, Les chercheurs de la Faculté des sciences de l'agriculture et de l'alimentation

  2. Rapport annuel des activits de recherche 2010-2011

    E-print Network

    Laval, Université

    'équilibre parfait #12; #12;Faculté des sciences de l'agriculture et de l'alimentation Rapport annuel des activités sciences de l'agriculture et de l'alimentation Vice-décanat à la recherche Madame, Monsieur, Je suis très des activités de recherche 2010-2011 de la Faculté des sciences de l'agriculture et de l'alimentation

  3. Implantation des Espaces de Travail I. Introduction.............................................................. 82

    E-print Network

    Donsez, Didier

    Chapitre 5 Implantation des Espaces de Travail I. Introduction Persistantes.....................................88 IV. Structure MultiThreadée des Espaces de Travail.... 105 : Implantation des Espaces de Travail - 82 - I. Introduction L'implantation des Espaces de Travail est basée sur

  4. PORTRAIT DES PERCEPTIONS RELATIVES L'ENVIRONNEMENT CONOMIQUE PAR

    E-print Network

    Asselin, Hugo

    PORTRAIT DES PERCEPTIONS RELATIVES À L'ENVIRONNEMENT ÉCONOMIQUE PAR LES COMMERÇANTS ET QUÉBEC EN ABITIBI-TÉMISCAMINGUE CHAIRE DESJARDINS EN DÉVELOPPEMENT DES PETITES COLLECTIVITÉS PORTRAIT DES;iii SOMMAIRE Cette enquête vise à tracer un portrait des perceptions relatives à l

  5. Journe des Nouveaux Entrants INEE, Paris, 4 Juillet 2013

    E-print Network

    van Tiggelen, Bart

    OHM & SEEG Journée des Nouveaux Entrants INEE, Paris, 4 Juillet 2013 1 Journée des Nouveaux Entrants INEE, Paris, 4 Juillet 2013 #12;Présenter deux outils de l'INEE pour l'étude des (socio INEE, Paris, 4 Juillet 2013 #12;3 Journée des Nouveaux Entrants INEE, Paris, 4 Juillet 2013 Ecologie

  6. Dplacer des tas de terre En 3 dimensions.

    E-print Network

    Pansu, Pierre

    le long d'un mur. #12;Monge : mémoire sur la théorie des déblais et des remblais (1776) A l'un marchand forain. A 14 ans, il invente une pompe à incendie. A 17 ans, il revient dans son collège enseigner froid de 1776 Machine à remonter les bateaux Théorie des torrents et des rivières et moyen d

  7. [Alpha-linolenic acid and cardiovascular diseases].

    PubMed

    Risti?-Medi?, Danijela; Risti?, Gordana; Tepsi?, Vesna

    2003-01-01

    IMPORTANCE AND METABOLISM OF ALPHA-LINOLENIC ACID: Alpha-linolenic acid is an essential fatty acid which cannot be produced in the body and must be taken by food. Both in animals and humans, alpha-linolenic acid is desaturated and elongated into eicosapentaenoic and docosahexaenoic acid. It is also incorporated into plasma and tissue lipids and its conversion is affected by levels of linoleic acid. POTENTIAL ROLE IN PATHOGENESIS OF CARDIOVASCULAR DISEASES: Diet enriched in n-3 fatty acids, especially alpha-linolenic acid, reduces the incidence of cardiac death. Studies have shown that alpha linolenic acid prevents ventricular fibrillation which is the main cause of cardiac death. Studies in rats suggest that alpha-linolenic acid may be more effective in preventing ventricular fibrillations than eicosapentaenoic and docosahexaenoic acid. Furthermore, alpha-linolenic acid is the main fatty acid decreasing platalet aggregation which is an important step in thrombosis i.e. non-fatal myocardial infarction and stroke. DIETARY SOURCES AND NUTRITION RECOMMENDATIONS: Dietary sources include flaxseed and flaxseed oil, canola oil, soybean and soybean oil, pumpkin seed and pumpkin oil, walnuts and walnut oil. Strong evidence supports beneficial effects of alpha-linolenic acid and its dietary sources should be incorporated into balanced diet for prevention of cardiovascular diseases. The recommended daily intake is 2 g with a ratio of 5/1 for linoleic/alpha-linolenic acid. PMID:15510909

  8. Gene transfer mediated by alpha2-macroglobulin.

    PubMed Central

    Schneider, H; Huse, K; Birkenmeier, G; Otto, A; Scholz, G H

    1996-01-01

    alpha2-Macroglobulin covalently linked to poly(L)-lysine can be used as a vehicle for receptor-mediated gene transfer. This modified alpha2-macroglobulin maintains its ability to bind to the alpha2-macroglobulin receptor, and was shown to introduce a luciferase reporter gene plasmid into HepG2 human hepatoma cells in vitro. The alpha2-macroglobulin receptor is a very large and multifunctional cell surface receptor, whose rapid and efficient internalization rate makes it attractive for gene therapy, e.g. for hepatic gene targeting via injection into the portal vein. PMID:8871570

  9. Repliement des protéines : exemple de l'?-lactalbumine

    NASA Astrophysics Data System (ADS)

    Bushmarina, N. A.; Blanchet, C.; Vernier, G.; Forge, V.

    2005-11-01

    Cette revue sur le repliement des protéines ne fait appel à aucune expérience propre de diffusion de neutrons. Elle décrit les aspects cinétiques et thermodynamiques de la structuration des protéines sur leur chemin de repliement, en faisant référence à des techniques biophysiques variées permettant d'échantillonner des changements conformationnels sur des échelles de temps longues (ms. à s.). Les neutrons constituent une sonde évidemment complémentaire des techniques usuellement employées pour l'étude du repliement des protéines. Nous avons choisi un modèle d'étude, l'?-lactalbumine, pour donner un état de l'art des connaissances acquises à ce jour dans le domaine, et pour ainsi inciter biophysiciens et spectroscopistes à développer des techniques en temps résolu sur des échelles plus rapides, afin de pouvoir détecter les étapes précoces du repliement. Les neutrons doivent trouver une place logique dans de tels développements.

  10. EEG alpha power and alpha power asymmetry in sleep and wakefulness

    E-print Network

    Wisconsin at Madison, University of

    during dreaming. During sleep, alpha power was highest during slow-wave sleep and lowest during REM sleepEEG alpha power and alpha power asymmetry in sleep and wakefulness RUTH M. BENCA,a,b WILLIAM H correlated with waking emotional reactivity and the emotional content of dream reports. Little is known

  11. Cross-talk between integrins {alpha}1{beta}1 and {alpha}2{beta}1 in renal epithelial cells

    SciTech Connect

    Abair, Tristin D.; Sundaramoorthy, Munirathinam; Chen, Dong; Heino, Jyrki; Ivaska, Johanna; Hudson, Billy G.; Sanders, Charles R.; Pozzi, Ambra; Zent, Roy

    2008-11-15

    The collagen-binding integrins {alpha}1{beta}1 and {alpha}2{beta}1 have profoundly different functions, yet they are often co-expressed in epithelial cells. When both integrins are expressed in the same cell, it has been suggested that {alpha}1{beta}1 negatively regulates integrin {alpha}2{beta}1-dependent functions. In this study we utilized murine ureteric bud (UB) epithelial cells, which express no functionally detectable levels of endogenous integrins {alpha}1{beta}1 and {alpha}2{beta}1, to determine the mechanism whereby this regulation occurs. We demonstrate that UB cells expressing integrin {alpha}2{beta}1, but not {alpha}1{beta}1 adhere, migrate and proliferate on collagen I as well as form cellular cords in 3D collagen I gels. Substitution of the transmembrane domain of the integrin {alpha}2 subunit with that of {alpha}1 results in decreased cell adhesion, migration and cord formation. In contrast, substitution of the integrin {alpha}2 cytoplasmic tail with that of {alpha}1, decreases cell migration and cord formation, but increases proliferation. When integrin {alpha}1 and {alpha}2 subunits are co-expressed in UB cells, the {alpha}1 subunit negatively regulates integrin {alpha}2{beta}1-dependent cord formation, adhesion and migration and this inhibition requires expression of both {alpha}1 and {alpha}2 tails. Thus, we provide evidence that the transmembrane and cytoplasmic domains of the {alpha}2 integrin subunit, as well as the {alpha}1 integrin subunit, regulate integrin {alpha}2{beta}1 cell function.

  12. Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist {alpha}-conotoxin OmIA that discriminates {alpha}3 vs. {alpha}6 nAChR subtypes

    SciTech Connect

    Chi, Seung-Wook; Kim, Do-Hyoung; Olivera, Baldomero M.; McIntosh, J. Michael; Han, Kyou-Hoon . E-mail: khhan600@kribb.re.kr

    2006-06-23

    {alpha}-Conotoxin OmIA from Conus omaria is the only {alpha}-conotoxin that shows a {approx}20-fold higher affinity to the {alpha}3{beta}2 over the {alpha}6{beta}2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of {alpha}-conotoxin OmIA by nuclear magnetic resonance spectroscopy. {alpha}-Conotoxin OmIA has an '{omega}-shaped' overall topology with His{sup 5}-Asn{sup 12} forming an {alpha}-helix. Structural features of {alpha}-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related {alpha}4/7 subfamily conotoxins. Reduced size of the hydrophilic area in {alpha}-conotoxin OmIA seems to be associated with the reduced affinity towards the {alpha}6{beta}2 nAChR subtype.

  13. Status of {alpha}{sub s} measurements

    SciTech Connect

    Hinchliffe, I.

    1993-05-05

    I review the current determinations of {alpha}{sub s}. Attention is given to the theoretical uncertainties inherent in most determinations. all current determinations are consistent with an average of {alpha}{sub s}(M{sub Z}) = 0.119{plus_minus}0.005. Prospects for reduction of the errors in the future are discussed.

  14. Coefficient Alpha Bootstrap Confidence Interval under Nonnormality

    ERIC Educational Resources Information Center

    Padilla, Miguel A.; Divers, Jasmin; Newton, Matthew

    2012-01-01

    Three different bootstrap methods for estimating confidence intervals (CIs) for coefficient alpha were investigated. In addition, the bootstrap methods were compared with the most promising coefficient alpha CI estimation methods reported in the literature. The CI methods were assessed through a Monte Carlo simulation utilizing conditions…

  15. Typical uncertainties in alpha-particle spectrometry

    NASA Astrophysics Data System (ADS)

    Pommé, S.

    2015-06-01

    Alpha-particle spectrometry is routinely performed with the aim of measuring absolute activities, activity ratios between different alpha-emitting nuclides or decay data such as branching factors, alpha emission probabilities and relative half-lives. It is most commonly performed with ion-implanted silicon detectors. Strong features of the technique are the low background levels that can be achieved due to low sensitivity to other types of radiation, the intrinsic efficiency close to 1 which reduces the efficiency calculations to a geometrical problem and the uniqueness of the energy spectra for each ?-decaying nuclide. The main challenge is the limitation to the attainable energy resolution, even with thin and homogenous sources, which causes alpha energy peaks to be partially unresolved due to their width and low-energy tailing. The spectral deconvolution often requires fitting of analytical functions to each peak in the alpha spectrum. True coincidence effects between alpha particles and subsequently emitted conversion electrons cause distortions of the alpha spectra which lead to significant changes in the apparent peak area ratios. Optimum energy resolution can only be achieved on very thin sources, which puts constraints on the source preparation techniques. Radiochemical separations may be needed to extract the alpha emitters from voluminous matrices and efficiency tracing is performed by adding in another isotope by known amounts. Typical uncertainty components are discussed by means of some hypothetical examples.

  16. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS FORMULAS FOR DENATURED ALCOHOL AND RUM Specifications for Denaturants § 21.95 Alpha terpineol. (a) Boiling point at...

  17. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL FORMULAS FOR DENATURED ALCOHOL AND RUM Specifications for Denaturants § 21.95 Alpha terpineol. (a) Boiling point at...

  18. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL FORMULAS FOR DENATURED ALCOHOL AND RUM Specifications for Denaturants § 21.95 Alpha terpineol. (a) Boiling point at...

  19. Monitoring pipes for residual alpha contamination

    SciTech Connect

    MacArthur, D.; Rawool-Sullivan, M.; Dockray, T.

    1996-09-01

    The sensitivity and application of traditional alpha monitors is limited by the short range of alpha particles in air and in solid materials. Detecting small amounts of alpha-emitting contamination inside pipes presents particular problems. The alpha particle cannot penetrate the walls of the pipe. Associated gamma-ray detection and active neutron interrogation is often used to detect large amounts of radioactive material in pipes, but these methods are of limited use for detecting small amounts of contamination. Insertion of a traditional alpha probes works well in large diameter straight pipes, but is increasingly difficult as the pipe network becomes smaller in diameter and more complex. Monitors based on long-range alpha detection (LRAD) detect ionization of the ambient air rather than the alpha particles themselves. A small fan draws the ions into an externally mounted ion detector. Thus, the air in the pipe serves as both the detector gas and the mechanism for transporting the alpha-induced ions to a detection grid outside the pipe. All of the ions created by all of the contamination in the pipe can be measured in a single detector. Since ambient air serves as the probe, crushed or twisted sections of pipe can be monitored almost as effectively as straight sections. The pipe monitoring system described in the paper was tested both at LANL and BNFL`s Sellafield reprocessing facility in the UK. In this paper, we report on the first field tests of the pipe monitoring system.

  20. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...and Firearms 1 2010-04-01 2010-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco...ALCOHOL AND RUM Specifications for Denaturants § 21.95 Alpha terpineol. (a) Boiling point at 752mm...

  1. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Alpha terpineol. (a) Boiling point at 752mm 218.8-219.4 °C. (b) Density at 15° 0.9386. (c)...

  2. 27 CFR 21.95 - Alpha terpineol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Alpha terpineol. 21.95 Section 21.95 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Alpha terpineol. (a) Boiling point at 752mm 218.8-219.4 °C. (b) Density at 15° 0.9386. (c)...

  3. Teaching Calculus with Wolfram|Alpha

    ERIC Educational Resources Information Center

    Dimiceli, Vincent E.; Lang, Andrew S. I. D.; Locke, LeighAnne

    2010-01-01

    This article describes the benefits and drawbacks of using Wolfram|Alpha as the platform for teaching calculus concepts in the lab setting. It is a result of our experiences designing and creating an entirely new set of labs using Wolfram|Alpha. We present the reasoning behind our transition from using a standard computer algebra system (CAS) to…

  4. Commentary on Coefficient Alpha: A Cautionary Tale

    ERIC Educational Resources Information Center

    Green, Samuel B.; Yang, Yanyun

    2009-01-01

    The general use of coefficient alpha to assess reliability should be discouraged on a number of grounds. The assumptions underlying coefficient alpha are unlikely to hold in practice, and violation of these assumptions can result in nontrivial negative or positive bias. Structural equation modeling was discussed as an informative process both to…

  5. Meta-Analysis of Coefficient Alpha

    ERIC Educational Resources Information Center

    Rodriguez, Michael C.; Maeda, Yukiko

    2006-01-01

    The meta-analysis of coefficient alpha across many studies is becoming more common in psychology by a methodology labeled reliability generalization. Existing reliability generalization studies have not used the sampling distribution of coefficient alpha for precision weighting and other common meta-analytic procedures. A framework is provided for…

  6. Rpertoire des emplois en dcembre 2011 Des diplms de Licence Professionnelle

    E-print Network

    Jeanjean, Louis

    gestion des automatismes (VEGA) (IUT de Belfort-Montbéliard) - Energie et génie climatique spécialité énergies renouvelables (IUT de Belfort-Montbéliard) - Gestion de la production industrielle spécialité

  7. Actes des Journes des Jeunes Chercheurs en Systmes Mmoire Logiquement Partage, Toulouse, Septembre 1993. Des Espaces de Travail Distribus

    E-print Network

    Donsez, Didier

    , Septembre 1993. WEA, Des Espaces de Travail Distribués à Objets Persistants Didier Donsez, Philippe Homond, Des Espaces de Travail Distribués à Objets Persistants 2 Le système WEA utilise ce deux techniques'architecture client-serveur. Ce modèle est fondé sur un graphe d'espaces de travail dont chacun peut être

  8. A low-energy determination of $\\alpha_s$ at three loops

    E-print Network

    Vairo, Antonio

    2015-01-01

    We review one of the most accurate low-energy determinations of $\\alpha_s$. Comparing at short distances the QCD static energy at three loops and resummation of the next-to-next-to leading logarithms with its determination in 2+1-flavor lattice QCD, we obtain $\\alpha_s(1.5~{\\rm GeV})=0.336^{+0.012}_{-0.008}$, which corresponds to $\\alpha_s(M_Z)=0.1166^{+0.0012}_{-0.0008}$. We discuss future perspectives.

  9. The alpha-chain-termination mutants and their relation to the alpha-thalassaemias.

    PubMed

    Weatherall, D J; Clegg, J B

    1975-08-01

    The structure, synthesis, genetic transmission, clinical associations and distribution of the elongated alpha-chain haemoglobin variants has been described. The data indicate that the most likely molecular basis for these common abnormal haemoglobins is a single base substitution in the alpha-chain termination codon. Because these variants are produced inefficiently they give rise to the clinical picture of alpha-thalassaemia. When these findings are taken together with recent work regarding the molecular basis for other forms of alpha-thalassaemia it is possible to build up a fairly complete picture of the molecular pathology of the alpha-thalassaemias. PMID:240178

  10. A portable swipe monitor for alpha contamination

    SciTech Connect

    Whitley, C.R.; Bounds, J.A.; Steadman, P.A.

    1998-06-01

    A portable swipe monitor has been developed at Los Alamos National Laboratory for the state of New Mexico. The monitor is intended for use at New Mexico ports of entry to detect removable alpha contamination on shipments bound for the proposed Waste Isolation Pilot Plant (WIPP). This detector uses Long-Range Alpha Detection (LRAD) technology, which monitors ionization created by alpha interactions with ambient air, and includes built-in background subtraction of external radiation fields and radon. In sensitivity to alpha contamination is on the order of a few tens of dpm, and it has excellent linearity throughout its entire range of over 200,000 counts per minute of alpha activity. Designed to be used primarily in the field, the monitor is battery-powered and can operate continuously for up to five hours.

  11. Practical alpha detectors for site characterization

    SciTech Connect

    Bounds, J.A.; Allander, K.S.; Bolton, R.B.; Garner, S.E.; Johnson, J.D.; Johnson, J.P.; MacArthur, D.W.; Sprouse, L.L.; Walters, S.G.

    1994-08-01

    The authors have and are developing a series of practical alpha detectors for alpha characterization. These include soil surface monitors, pipe and duct monitors, air quality and radon monitors, tool monitors, and sample monitors. Two types of these monitors have been transferred to industry thus far for commercialization. Several of these systems have been fully field tested: for example, the soil surface monitor has been used to characterize 11 sites for 7 customers at 3 DOE facilities. Using a new but simple technology, these alpha detectors can be put to use in many areas where conventional alpha probes are impractical or insufficiently sensitive. Use of these alpha detectors in site characterization at the Uranium in Soil Integrated Demonstration at Fernald, at Los Alamos, and elsewhere will be discussed as well as their commercialization and possible further applications.

  12. Long-range alpha detector (LRAD)

    SciTech Connect

    MacArthur, D.W.; McAtee, J.L.

    1991-01-01

    Historically, alpha detectors have been limited by the very short range of alpha particles in air and by relatively poor sensitivity, even if the particles are intercepted. Of necessity, these detectors are operated in a vacuum or in close proximity to the source if reasonable efficiency is desired. In our new long-range alpha detector (LRAD), alpha particles interact with the ambient air, producing ionization in the air at the rate of about 30,000 ion pairs per MeV of alpha energy. These charges can be transported over significant distances (several meters) in a moving current of air generated by a small fan. An ion chamber located in front of the fan measures the current carried by the moving ions. The LRAD-based monitor is more sensitive and more thorough than conventional monitors. We present current LRAD sensitivity limits and results, practical monitor designs, and proposed uses for LRAD monitors. 4 refs., 7 figs.

  13. Alpha1 and Alpha2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression

    SciTech Connect

    Lochter, Andre; Navre, Marc; Werb, Zena; Bissell, Mina J

    1998-06-29

    Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits {alpha}6 and {beta}1, but not against {alpha}1 and {alpha}2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against {beta}1, but not against a6 or {alpha}2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against {alpha}1 integrins impaired only cell adhesion to type IV collagen. Antibodies against {alpha}1, {alpha}2, {alpha}6, and {beta}1, but not {alpha}5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins {alpha}1 and {alpha}2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against {alpha}1 and {alpha}2, but not {alpha}6 and {beta}1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against {alpha}1 and {alpha}2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-{alpha}6 antibodies. Our data indicate that {alpha}1 and {alpha}2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas {alpha}6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion.

  14. Catalytic Mechanism of Human Alpha-galactosidase

    SciTech Connect

    Guce, A.; Clark, N; Salgado, E; Ivanen, D; Kulinskaya, A; Brumer, H; Garman, S

    2010-01-01

    The enzyme {alpha}-galactosidase ({alpha}-GAL, also known as {alpha}-GAL A; E.C. 3.2.1.22) is responsible for the breakdown of {alpha}-galactosides in the lysosome. Defects in human {alpha}-GAL lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of {alpha}-galactosylated substrates in the tissues. {alpha}-GAL is an active target of clinical research: there are currently two treatment options for Fabry disease, recombinant enzyme replacement therapy (approved in the United States in 2003) and pharmacological chaperone therapy (currently in clinical trials). Previously, we have reported the structure of human {alpha}-GAL, which revealed the overall structure of the enzyme and established the locations of hundreds of mutations that lead to the development of Fabry disease. Here, we describe the catalytic mechanism of the enzyme derived from x-ray crystal structures of each of the four stages of the double displacement reaction mechanism. Use of a difluoro-{alpha}-galactopyranoside allowed trapping of a covalent intermediate. The ensemble of structures reveals distortion of the ligand into a {sup 1}S{sub 3} skew (or twist) boat conformation in the middle of the reaction cycle. The high resolution structures of each step in the catalytic cycle will allow for improved drug design efforts on {alpha}-GAL and other glycoside hydrolase family 27 enzymes by developing ligands that specifically target different states of the catalytic cycle. Additionally, the structures revealed a second ligand-binding site suitable for targeting by novel pharmacological chaperones.

  15. Prendre le virage des partenariats.

    PubMed

    Sebestyen, Norma; Sulatycky, Ron; Rondos, Spyro; Davis, Sheila

    2015-11-01

    Deux projets démontrent que la mise en œuvre de données colligées sur le terrain peut contribuer à régler des problèmes dans le milieu de la santé pour favoriser de meilleurs résultats et de plus grandes efficiences. Dans le premier exemple, une vaste coalition de partenaires publics et privés de l'Alberta recourt aux techniques de mesures améliorées et à la méthodologie du Triple objectif pour améliorer les résultats cliniques de populations de cas complexes et lourds du quartier Eastwood d'Edmonton. On espère que les conclusions novatrices qui en sont tirées seront adaptées à d'autres régions de la province. Dans le deuxième exemple, la Childhood Obesity Foundation s'associe à Merck au Canada et à Ayogo (une société de thérapies numériques située à Vancouver) et utilise le concept novateur de la « ludification » pour mobiliser les jeunes de plus en plus sédentaires du Canada et modifier leurs comportements. PMID:26482219

  16. {alpha} ratio 2n ratio {alpha} Molecular Band in {sup 10}Be

    SciTech Connect

    Freer, M.; Ashwood, N.I.; Curtis, N.; Price, D.; Ziman, V.A.; Casarejos, E.; Angulo, C.; Demaret, P.; Harlin, C.; Milin, M.; Soic, N.; Raabe, R.

    2006-02-03

    The 10.15 MeV resonance in {sup 10}Be has been probed via resonant {sup 6}He+{sup 4}He elastic scattering. It is demonstrated that it is the J{sup {pi}}=4{sup +} member of a rotational band built on the 6.18 MeV 0{sup +} state. A {gamma}{sub {alpha}} of 0.10-0.13 MeV and {gamma}{sub {alpha}}/{gamma}=0.35-0.46 were deduced. The corresponding reduced {alpha} width, {gamma}{sub {alpha}}{sup 2}, indicates one of the largest {alpha}-cluster spectroscopic factors known. The deformation of the band, including the 7.54 MeV, 2{sup +} member, is large (({Dirac_h}/2{pi}){sup 2}/2I=200 keV). Such a deformation and the significant degree of clusterization signals a well-developed {alpha} ratio 2n ratio {alpha} molecular structure.

  17. Restauration des pelouses calcaires Les abeilles solitaires

    E-print Network

    Rasmont, Pierre

    régulièrement plusieurs nids au cours de la saison (Jacob-Remacle 1989, 1990; Westrich 1989, 1990). Une fois suite à la récente interruption de l'activité d'extraction dans le courant des années 1990 (A. Remacle

  18. Fachprfungsordnung des Masterstudiengangs Health Care Management

    E-print Network

    Greifswald, Ernst-Moritz-Arndt-Universität

    Fachprüfungsordnung des Masterstudiengangs Health Care Management an der Ernst-Moritz-Arndt-Universität Greifs- wald die folgende Prüfungsordnung für den Masterstudiengang (M. Sc.) ,,Health Care Management Prüfungsverfahren im Studiengang ,,Health Care Management". Ergänzend gilt die Gemeinsame Prüfungsord- nung für

  19. Christian Blanchette Responsable de la gestion des

    E-print Network

    Charette, André

    Directeur de la gestion des programmes Richard St-Onge Directrice de la Formation continue Florence Bordage technopédagogique Justine Castonguay-Payant Coordonnateurs MICC Christiane Labelle Bernard Lévesque et Marco Moraes

  20. Écologie des soins de santé au Canada

    PubMed Central

    Stewart, Moira; Ryan, Bridget

    2015-01-01

    Résumé Objectif Présenter un profil populationnel pancanadien des besoins en soins de santé et de leur utilisation, facile d’accès et permettant des comparaisons entre les provinces et avec d’autres instances internationales. Conception Une comparaison des taux d’utilisation des soins de santé entre les provinces en utilisant des données d’enquêtes et des renseignements administratifs sur la santé. Contexte Les provinces du Canada. Principaux paramètres à l’étude Les taux canadiens et provinciaux de personnes en mauvaise santé (présence de problèmes chroniques) et d’utilisation des soins de santé (contacts avec des médecins de famille, avec d’autres médecins spécialistes, avec des infirmières et hospitalisations) sous forme de proportions mensuelles par 1000 habitants normalisées en fonction de l’âge et du genre. Résultats La proportion mensuelle par 1000 habitants de personnes souffrant d’au moins 1 problème chronique variait de 524 au Québec à 638 en Nouvelle-Écosse; les contacts avec un médecin de famille se situaient entre 158 au Québec et 295 en Colombie-Britannique; les contacts avec d’autres médecins spécialistes variaient entre 53 en Saskatchewan et 79 en Ontario; et le nombre de contacts avec des infirmières se situait entre 23 en Colombie-Britannique et 41 au Québec. Le nombre de séjours à l’hôpital variait entre 8 et 11 par 1000 habitants et les proportions étaient semblables d’une province à l’autre. Conclusion Il est essentiel de reconnaître les distinctions entre les provinces pour éclairer les politiques sur la santé dans l’ensemble du pays. Les différences persistaient lorsque les taux étaient normalisés en fonction de la composition démographique variable selon l’âge et le genre dans les provinces. Cet article présente une méthodologie simple à l’aide de données publiquement accessibles qui peut servir dans chaque province à examiner, à l’avenir, l’évolution avec le temps de l’utilisation des soins de santé par les instances provinciales.

  1. Die Erheblichkeit Des Humanismus In Durftiger Zeit

    E-print Network

    Kohak, Erazim

    Objekts wie ihn auch Auguste Comte verstanden hat. Die Kritik ist aber nicht stichhaltig gegenüber dem Positivismus des sinnhaften Erlebnisses, den Edmund Husserl in seinem Entwurf der Phänomenologie hervorbringt. Daher sind wir zu dem Schluß gekommen... ganz deutlich in Masaryks Humanismus geäussert, aber nicht nur dort. Der Gründer des modernen Positivismus, Auguste Com te, war auch derjenige Philosoph, der einen "Kult der Humanität" vorgeschlagen hat. Der britische Empirizist John Locke hat die...

  2. Elements de mecanique des milieux continus

    E-print Network

    Hauret, Patrice

    Chapitre 2 El´ements de m´ecanique des milieux continus Afin de faciliter la lecture du pr´esent travail et de formuler en totalit´e le probl`eme m´ecanique qui le motive, nous rappelons ici quelques ´el´etail compl´ementaire en ce qui concerne la m´ecanique des milieux continus, on pourra consulter les ouvrages

  3. Une petite1 histoire des nombres premiers

    E-print Network

    Jeanjean, Louis

    Une petite1 histoire des nombres premiers Vieux probl`emes et perc´ees r´ecentes Jean-Robert Belliard IREM Franche-Comt´e 1 Merci `a Nicolas Jacon Jean-Robert Belliard (IREM Franche-Comt´e) Une petite petite histoire des nombres premiers 2 / 31 #12;Qu'est ce qu'un nombre premier ? Jean-Robert Belliard

  4. Local structure and vibrational properties of alpha-Pu, alpha-Uand the alpha-U charge density wave

    SciTech Connect

    Nelson, E.J.; Allen, P.G.; Blobaum, K.J.M.; Wall, W.A.; Booth, C.H.

    2004-08-10

    The local atomic environment and vibrational properties of atoms in monoclinic pure {alpha}-plutonium as well as orthorhombic pure a-uranium and its low-temperature charge-density-wave (CDW) modulation are examined by extended x-ray absorption fine structure spectroscopy (EXAFS). Pu L{sub III}-edge and U L{sub III}-edge EXAFS data measured at low temperatures verify the crystal structures of {alpha}-U and {alpha}-Pu samples previously determined by x-ray diffraction and neutron scattering. Debye-Waller factors from temperature-dependent EXAFS measurements are fit with a correlated Debye model. The observed Pu-Pu bond correlated Debye temperature of {theta}{sub cD}({alpha}-Pu) = 162 {+-} 5 K for the pure {alpha}-Pu phase agrees with our previous measurement of the correlated Debye temperature of the gallium-containing {alpha}{prime}-Pu phase in a mixed phase 1.9 at% Ga-doped {alpha}{prime}-Pu/{delta}-Pu alloy. The temperature dependence of the U-U nearest neighbor Debye-Waller factor exhibits a sharp discontinuity in slope near T{sub CDW} = 43 K, the transition temperature at which the charge-density wave (CDW) in {alpha}-U condenses from a soft phonon mode along the (100) direction. Our measurement of the CDW using EXAFS is the first observation of the structure of the CDW in polycrystalline {alpha}-U. The different temperature dependence of the Debye-Waller factor for T < T{sub CDW} can be modeled by the change in bond length distributions resulting from condensation of the charge density wave. For T > T{sub CDW}, the observed correlated Debye temperature of {theta}{sub cD}({alpha}-U) = 199 {+-} 3 K is in good agreement with other measurements of the Debye temperature for polycrystalline {alpha}-U. CDW structural models fit to the {alpha}-U EXAFS data support a squared CDW at the lowest temperatures, with a displacement amplitude of {var_epsilon} = 0.05 {+-} 0.02 {angstrom}.

  5. Caracterisation des proprietes acoustiques des materiaux poreux a cellules ouvertes et a matrice rigide ou souple

    NASA Astrophysics Data System (ADS)

    Salissou, Yacoubou

    L'objectif global vise par les travaux de cette these est d'ameliorer la caracterisation des proprietes macroscopiques des materiaux poreux a structure rigide ou souple par des approches inverses et indirectes basees sur des mesures acoustiques faites en tube d'impedance. La precision des approches inverses et indirectes utilisees aujourd'hui est principalement limitee par la qualite des mesures acoustiques obtenues en tube d'impedance. En consequence, cette these se penche sur quatre problemes qui aideront a l'atteinte de l'objectif global precite. Le premier probleme porte sur une caracterisation precise de la porosite ouverte des materiaux poreux. Cette propriete en est une de passage permettant de lier la mesure des proprietes dynamiques acoustiques d'un materiau poreux aux proprietes effectives de sa phase fluide decrite par les modeles semi-phenomenologiques. Le deuxieme probleme traite de l'hypothese de symetrie des materiaux poreux selon leur epaisseur ou un index et un critere sont proposes pour quantifier l'asymetrie d'un materiau. Cette hypothese est souvent source d'imprecision des methodes de caracterisation inverses et indirectes en tube d'impedance. Le critere d'asymetrie propose permet ainsi de s'assurer de l'applicabilite et de la precision de ces methodes pour un materiau donne. Le troisieme probleme vise a mieux comprendre le probleme de transmission sonore en tube d'impedance en presentant pour la premiere fois un developpement exact du probleme par decomposition d'ondes. Ce developpement permet d'etablir clairement les limites des nombreuses methodes existantes basees sur des tubes de transmission a 2, 3 ou 4 microphones. La meilleure comprehension de ce probleme de transmission est importante puisque c'est par ce type de mesures que des methodes permettent d'extraire successivement la matrice de transfert d'un materiau poreux et ses proprietes dynamiques intrinseques comme son impedance caracteristique et son nombre d'onde complexe. Enfin, le quatrieme probleme porte sur le developpement d'une nouvelle methode de transmission exacte a 3 microphones applicable a des materiaux ou systemes symetriques ou non. Dans le cas symetrique, on montre que cette approche permet une nette amelioration de la caracterisation des proprietes dynamiques intrinseques d'un materiau. Mots cles. materiaux poreux, tube d'impedance, transmission sonore, absorption sonore, impedance acoustique, symetrie, porosite, matrice de transfert.

  6. Profil épidémiologique des tumeurs malignes primitives des glandes salivaires : à propos de 154 cas

    PubMed Central

    Setti, Khadija; Mouanis, Mohamed; Moumni, Abdelmounim; Maher, Mostafa; Harmouch, Amal

    2014-01-01

    Introduction Les tumeurs des glandes salivaires sont des tumeurs rares représentant 3à 5% des tumeurs de la tête et du cou. La classification de l'OMS 2005 distingue les tumeurs épithéliales, les tumeurs mésenchymateuses, les tumeurs hématologiques et les tumeurs secondaires. Méthodes Notre travail consiste en une étude rétrospective réalisée sur une période de 10 ans allant de janvier 2002 à janvier 2012. Les critères d'inclusion étaient: l'âge, le sexe, le siège de la tumeur et le type histologique. Résultats L'incidence annuelle des tumeurs malignes primitives des glandes salivaires dans notre série était de 15 cas par an. Cent cinquante quatre cas de tumeurs malignes primitives des glandes salivaires ont été colligés sans prédominance de sexe (78 femmes (50,6%) et 76 hommes (49,4%)). La moyenne d'âge était de 60 ans avec des extrêmes de 4 et 83 ans et un pic de fréquence entre 51et 70 ans. Deux tiers des cas (65%) avaient une localisation au niveau des glandes principales avec 66 cas au niveau de la parotide (43%) et 34 cas au niveau de la glande sous maxillaire (22%). Cinquante quatre patients avaient une tumeur maligne des glandes salivaires accessoires (35%) dont 61% au niveau du palais. Aucun cas de tumeur maligne de la glande sublinguale n'a été recensé dans notre étude. Le type histologique prédominant dans notre série était le carcinome adénoïde kystique et retrouvé chez 43 patients (27,9%), suivi de l'adénocarcinome sans autre indication chez 37 patients (24%) puis du carcinome mucoépidermoïde chez 16 patients (10,4%) et de l'adénocarcinome polymorphe de bas grade également chez 16 patients (10. 4%). Conclusion Les tumeurs malignes des glandes salivaires représentent un ensemble hétérogène de maladies de caractérisation complexe et de fréquence variable. PMID:25120861

  7. La microscopie ionique analytique des tissus biologiques

    NASA Astrophysics Data System (ADS)

    Galle, P.

    Proposed in 1960 by R. Castaing and G. Slodzian, secondary ion emission microanalysis is a microanalytical method which is now largely used for the study of inert material. The instrument called the analytical ion microscope can also be used for the study of biological spécimens ; images representing the distribution of a given stable or radioactive isotope in a tissue section are obtained with a resolution of 0.5 ?m. Among the characteristics of this method, two are of particular interest in biological research : its capacity for isotopic analysis and its very high sensitivity which makes possible for the first time a chemical analysis of element at a very low or even at a trace concentration in a microvolume. Proposé en 1960 par R. Castaing et G. Slodzian, la microanalyse par émission ionique secondaire est une méthode qui permet, entre autre, d'obtenir des images représentant la distribution des isotopes présents à la surface d'un échantillon solide avec une résolution de 0,5 ?m. D'intérêt très général, cette méthode a été d'abord largement utilisée pour l'étude des matériaux inertes. Elle offre en outre des possibilités entièrement nouvelles dans le domaine de la recherche biomédicale. L'instrument réalisé, le microscope ionique analytique présente deux caractéristiques particulièrement intéressantes pour la biologie : la possibilité d'analyse isotopique, et l'extrême sensibilité permettant de détecter et de localiser dans une coupe histologique des éléments à des concentrations très faibles voire à l'état de trace.

  8. Des ports, des ports, encore des ports ? En Mditerrane, le plateau continental est gnralement troit, de telle sorte que les fonds de

    E-print Network

    Boudouresque, Charles F.

    Des ports, des ports, encore des ports ? En Méditerranée, le plateau continental est généralement Sahara. Tous les aménagements littoraux (ports, endigages, plages artificielles) sont concentrés sur les port tous les 7 km de côte ; ce chiffre tombe à 5 km en région PACA, et à 3 km si l'on considère le

  9. Karen Wiebe, Ph. D. ur les rives des lacs, des tangs et des cours d'eau, les sols sont humides et fertiles et

    E-print Network

    Karen Wiebe, Ph. D. Chercheure S U s s s s photo of researcher ur les rives des lacs, des étangs et des cours d'eau, les sols sont humides et fertiles et la végétation est abondante et variée. Cet habitat est peuplé d'animaux de toutes sortes, qui peuvent y chercher refuge contre leurs prédateurs et y

  10. Scalable encryption using alpha rooting

    NASA Astrophysics Data System (ADS)

    Wharton, Eric J.; Panetta, Karen A.; Agaian, Sos S.

    2008-04-01

    Full and partial encryption methods are important for subscription based content providers, such as internet and cable TV pay channels. Providers need to be able to protect their products while at the same time being able to provide demonstrations to attract new customers without giving away the full value of the content. If an algorithm were introduced which could provide any level of full or partial encryption in a fast and cost effective manner, the applications to real-time commercial implementation would be numerous. In this paper, we present a novel application of alpha rooting, using it to achieve fast and straightforward scalable encryption with a single algorithm. We further present use of the measure of enhancement, the Logarithmic AME, to select optimal parameters for the partial encryption. When parameters are selected using the measure, the output image achieves a balance between protecting the important data in the image while still containing a good overall representation of the image. We will show results for this encryption method on a number of images, using histograms to evaluate the effectiveness of the encryption.

  11. Lyman Alpha Spicule Observatory (LASO)

    NASA Technical Reports Server (NTRS)

    Chamberlin, Phillip C.

    2011-01-01

    The Lyman Alpha Spicule Observatory (LASO) sounding rocket will observe smallscale eruptive events called "Rapid Blue-shifted Events" (RBEs) [Rouppe van der Voort et al., 2009], the on-disk equivalent of Type-II spicules, and extend observations that explore their role in the solar coronal heating problem [De Pontieu et al., 2011]. LASO utilizes a new and novel optical design to simultaneously observe two spatial dimensions at 4.2" spatial resolution (2.1" pixels) over a 2'x2' field of view with high spectral resolution of 66mAngstroms (33mAngstroms pixels) across a broad 20Angstrom spectral window. This spectral window contains three strong chromospheric and transition region emissions and is centered on the strong Hydrogen Lyman-a emission at 1216Angstroms. This instrument makes it possible to obtain new data crucial to the physical understanding of these phenomena and their role in the overall energy and momentum balance from the upper chromosphere to lower corona. LASO was submitted March 2011 in response to the ROSES SHP-LCAS call.

  12. Fibrinogen {alpha} genes: Conservation of bipartite transcripts and carboxy-terminal-extended {alpha} subunits in vertebrates

    SciTech Connect

    Fu, Y.; Cao, Y.; Hertzberg, K.M.; Grieninger, G.

    1995-11-01

    All three well-studied subunits of the clotting protein fibrinogen ({alpha}, {beta}, {gamma}) share N-terminal structural homologies, but until recently only the {beta} and {gamma} chains were recognized as having similar globular C-termini. With the discovery of an extra exon in the human fibrinogen {alpha} gene (exon VI), a minor form of the {alpha} subunit ({alpha}{sub E}) with an extended {beta}- and {gamma}-like C-terminus has been identified. In the present study, the polymerase chain reaction has been used to identify sequences that encode counterparts to {alpha}{sub E} in chicken, rabbit, rat, and baboon. The basic six-exon structure of the fibrinogen {alpha} genes is shown to be conserved among mammals and birds, as are the intron positions. Bipartite transcripts - still bearing an intron prior to the last exon - are found among the products of the various vertebrate fibrinogen {alpha} genes. The last exon represents the largest conserved segment of the gene and, in each species examined, encodes exactly 236 amino acids. The C-termini of these {alpha}{sub E} chains align without a single gap and are between 76 and 99% identical. Since the exon VI-encoded domain of {alpha}{sub E} is as well conserved as the corresponding regions of the {beta} and {gamma} chains, it follows that it is equally important and that {alpha}{sub E}-fibrinogen plays a vital, if as-yet unrecognized physiological role. 21 refs., 7 figs., 1 tab.

  13. Influence de la dépendance en température des propriétés optiques des matériaux sur la force de Casimir

    NASA Astrophysics Data System (ADS)

    Joulain, K.; Henkel, C.; Greffet, J.-J.

    2006-10-01

    Nous évaluons la force de Casimir entre deux surfaces planes métalliques constituées d'argent. Nous prenons, pour effectuer cette évaluation, des propriétés optiques de l'argent à différentes températures [1]. Nous montrons que cette dépendance en température modifie la force de Casimir (de 0.2%) y compris à des distances inférieures à la longueur d'onde thermique.

  14. Polythiophènes substitués par des motifs tétrathiafulvalènes : vers des matériaux électroactifs à conductivité mixte

    NASA Astrophysics Data System (ADS)

    Huchet, L.; Roncali, J.

    1998-06-01

    Highly electroactive conjugated polymers have been synthesized by electropolymerisation of tetrathiafulvalene-derivatised bithiophenes. We report and discuss the electrochemical and optical properties of these new polymers. Des polymères conjugués fortement électroactifs ont été synthétisés par électropolymérisation de bithiophènes dérivés du tétrathiafulvalène. Nous présentons et discutons des caractéristiques électrochimiques et optiques de ces nouveaux polymères.

  15. BIO3515 -Biologie de la conservation des espces BIO 3515 Biologie de la conservation des espces

    E-print Network

    Blouin-Demers, Gabriel

    BIO3515 - Biologie de la conservation des espèces BIO 3515 ­ Biologie de la de Biologie Department of Biology Université d'Ottawa University of Ottawa 30 Marie-Curie Ottawa ! de !1 11 #12;BIO3515 - Biologie de la conservation des espèces 1 -- Après votre solide

  16. Premire pierre des futurs btiments de la Maison des sciences de l'homme et de

    E-print Network

    Jeanjean, Louis

    1 Première pierre des futurs bâtiments de la Maison des sciences de l'homme et de l par la Préfecture de Région et le Rectorat de l'Académie de Franche-Comté, préconisait : "Enfin, il faudrait structurer et dynamiser la recherche en sciences humaines et sociales à travers la création d

  17. DYNAMIQUE DES SYST`EMES D'ISOM'ETRIES : SUR LES BOUTS DES ORBITES

    E-print Network

    Gaboriau, Damien

    DYNAMIQUE DES SYST`EMES D'ISOM'ETRIES : SUR LES BOUTS DES ORBITES Damien Gaboriau Un syst`eme d'isom'etries (de dimension un) est une r'eunion finie D d'interv* *alles compacts de R, munie d'une famille finie '1, '2, . .,.'k d'isom

  18. Contrle pour des systmes gouverns par des quations aux drives partielles

    E-print Network

    Jeanjean, Louis

    à vapeurs (J. Watt en 1769), etc Voir l'article de James Clerk Maxwell dont l'article On governors), régulation de vitesse des machines à vapeurs (J. Watt en 1769), etc Voir l'article de James Clerk Maxwell vitesse des machines à vapeurs (J. Watt en 1769), etc Voir l'article de James Clerk Maxwell dont l

  19. Dtection robuste et automatique des contours myocardiques sur des squences IRM cardiaques marques

    E-print Network

    Histace, Aymeric

    Détection robuste et automatique des contours myocardiques sur des séquences IRM cardiaques et le suivi de patho- logies cardio-vasculaires. L'IRM cardiaque marquée (ou taggée) permet de satisfying results in term of precision but also in term of reproducibility. 1 Introduction L'IRM de marquage

  20. EXTRACTION DE CONNAISSANCES PARTIR DES DONNEES ET DES TEXTES (ECD ET ECT "DATA & TEXT MINING")

    E-print Network

    Spagnolo, Filippo

    1 EXTRACTION DE CONNAISSANCES � PARTIR DES DONNEES ET DES TEXTES (ECD ET ECT "DATA & TEXT MINING'Extraction de Connaissances à partir de Données (ECD, "Data Mining"). Le point fondamental qui distingue ces IN DATA AND TEXTS," defines Knowledge Discovery in Texts (KDT, or Text Mining, TM) as a continuation

  1. Alpha spectral analysis via artificial neural networks

    SciTech Connect

    Kangas, L.J.; Hashem, S.; Keller, P.E.; Kouzes, R.T.; Troyer, G.L.

    1994-10-01

    An artificial neural network system that assigns quality factors to alpha particle energy spectra is discussed. The alpha energy spectra are used to detect plutonium contamination in the work environment. The quality factors represent the levels of spectral degradation caused by miscalibration and foreign matter affecting the instruments. A set of spectra was labeled with a quality factor by an expert and used in training the artificial neural network expert system. The investigation shows that the expert knowledge of alpha spectra quality factors can be transferred to an ANN system.

  2. GAS KINEMATICS IN Ly{alpha} NEBULAE

    SciTech Connect

    Yang Yujin; Jahnke, Knud; Zabludoff, Ann; Eisenstein, Daniel; Dave, Romeel; Shectman, Stephen A.; Kelson, Daniel D.

    2011-07-10

    Exploring the origin of Ly{alpha} nebulae ('blobs') at high redshift requires measurements of their gas kinematics that are impossible with only the resonant, optically thick Ly{alpha} line. To define gas motions relative to the systemic velocity of the blob, the Ly{alpha} line must be compared with an optically thin line like H{alpha} {lambda}6563, which is not much altered by radiative transfer effects and is more concentrated about the galaxies embedded in the nebula's core. We obtain optical and near-IR (NIR) spectra of the two brightest Ly{alpha} blobs (CDFS-LAB01 and CDFS-LAB02) from the Yang et al. sample using the Magellan/Magellan Echellette Spectrograph optical and Very Large Telescope/SINFONI NIR spectrographs. Both the Ly{alpha} and H{alpha} lines confirm that these blobs lie at the survey redshift, z {approx} 2.3. Within each blob, we detect several H{alpha} sources, which roughly correspond to galaxies seen in Hubble Space Telescope rest-frame UV images. The H{alpha} detections show that these galaxies have large internal velocity dispersions ({sigma}{sub v} = 130-190 km s{sup -1}) and that, in the one system (LAB01), where we can reliably extract profiles for two H{alpha} sources, their velocity difference is {Delta}v {approx} 440 km s{sup -1}. The presence of multiple galaxies within the blobs, and those galaxies' large velocity dispersions and large relative motion, is consistent with our previous finding that Ly{alpha} blobs inhabit massive dark matter halos that will evolve into those typical of present-day rich clusters and that the embedded galaxies may eventually become brightest cluster galaxies. To determine whether the gas near the embedded galaxies is predominantly infalling or outflowing, we compare the Ly{alpha} and H{alpha} line centers, finding that Ly{alpha} is not offset ({Delta}v{sub Ly{alpha}} = +0 km s{sup -1}) in LAB01 and redshifted by only +230 km s{sup -1} in LAB02. These offsets are small compared to those of Lyman break galaxies, which average +450 km s{sup -1} and extend to about +700 km s{sup -1}. In LAB02, we detect C II {lambda}1334 and Si II {lambda}1526 absorption lines, whose blueward shifts of {approx}200 km s{sup -1} are consistent with the small outflow implied by the redward shift of Ly{alpha}. We test and rule out the simplest infall models and those outflow models with super/hyperwinds, which require large outflow velocities. Because of the unknown geometry of the gas distribution and the possibility of multiple sources of Ly{alpha} emission embedded in the blobs, a larger sample and more sophisticated models are required to test more complex or a wider range of infall and outflow scenarios.

  3. Communiqu de presse 17 fvrier 2015 Impact grande chelle des pesticides

    E-print Network

    attendu, mais aussi dans ceux traités par des herbicides. A l'inverse, ces insectes sont plus abondants-limaces. Si l'impact des insecticides sur les insectes est direct, celui des herbicides serait indirect, en sont moins abondants dans les parcelles agricoles traitées par des herbicides, des insecticides ou des

  4. Developpement des betons semi autoplacants a rheologie adaptee pour des infrastructures

    NASA Astrophysics Data System (ADS)

    Sotomayor Cruz, Cristian Daniel

    Au cours des dernières décennies, les infrastructures canadiennes et québécoises comportent plusieurs structures en béton armé présentant des problèmes de durabilité dus aux conditions climatiques sévères, à la mauvaise conception des structures, à la qualité des matériaux, aux types des bétons choisis, aux systèmes de construction ou à l'existence d'événements incontrôlables. En ce qui concerne le choix du béton pour la construction des infrastructures, une vaste gamme de béton divisée en deux principaux types peut être utilisée: le béton conventionnel vibré (BCV) et le béton autoplaçant (BAP). Dans le cas d'un BCV, la consolidation inadéquate par vibration a été un problème récurrent, occasionnant des dommages structuraux. Ceci a conduit à une réduction de la durabilité et à une augmentation du coût d'entretien et de réparation des infrastructures. Rien que l'utilisation d'un BAP a des avantages tels que l'élimination de la vibration, la réduction des coûts de main d'oeuvre et l'amélioration de la qualité des structures, néanmoins, le coût initial d'un BAP par rapport à un BCV ne permet pas encore de généraliser son utilisation dans l'industrie de la construction. Ce mémoire présente la conception d'une nouvelle gamme de béton semi-autoplaçant pour la construction des infrastructures (BSAP-I) exigeant une vibration minimale. Il s'agit de trouver un équilibre optimal entre la rhéologie et le coût initial du nouveau béton pour conférer une bonne performance structurale et économique aux structures. Le programme expérimental établi a premièrement permis d'évaluer la faisabilité d'utilisation des BSAP-I pour la mise en place des piliers d'une infrastructure de pont à Sherbrooke. En plus, l'utilisation d'un plan d'expériences a permis l'évaluation de trois paramètres de formulation sur les propriétés des mélanges de BSAP-I à l'état frais et durci. Finalement, l'évaluation de la performance des BSAP-I optimisés à travers une caractérisation complète des propriétés mécaniques et de la durabilité a été réalisée. A la suite de cette étude, les résultats obtenus nous permettent de conclure que : (1) L'utilisation d'un BSAP-I avec un gros granulat de 5 - 14 mm, des rapports E/L = 0,37 et S/G = 0,52 et une teneur en air de 6 à 9% a été possible en conférant un équilibre optimal fluidité / stabilité à l'état frais, ainsi qu'un niveau de thixotropie adéquate au chantier permettant d'optimiser la conception du coffrage des piliers de pont et de conférer des qualités de surfaces très acceptables de ces infrastructures. (2) La méthode adaptée pour l'essai L-Box contenant 2 barres et une vibration de 5 secondes a permis de bien caractériser la capacité de remplissage d'un BSAP-I. (3) L'utilisation d'un plan factoriel 23 a permis d'obtenir des modèles statistiques fiables, capables de prédire les propriétés rhéologiques à l'état frais et les résistances en compression des BSAP-I avec des dosages en liant entre 370 et 420 kg/m3, des rapports E/L entre 0,34 et 0,40 et S/G entre 0,47 et 0,53. (4) Des mesures de vitesse d'écoulement T40 d'un BSAP-I sont très semblables à celles d'un BAP. En plus, des valeurs T40 montrent une bonne corrélation linéaire avec celles de T400 mesurés dans la boîte L-Box. (5) À la frontière du BAP et du BCV, une bande rhéologique possédant un ?0 entre 30 et 320 Pa et un ? entre 10 et 140 Pa.s a été trouvée pour la conception optimale des BSAP-I. (6) Les BSAP-I optimisés ont également conféré une très bonne performance à l'état frais, en permettant maintenir un bon équilibre entre la rhéologie et la stabilité dans le temps, lorsqu'on utilise une énergie de vibration minimale pour amorcer son écoulement. (7) À l'état durci Les BSAP-I ont conféré une bonne performance présentant des résistances mécaniques élevées et des niveaux négligeables de pénétration aux ions chlores, de perte de masse par écaillage et des attaques par le gel/dégel. (8) L'utilisation des cim

  5. Alpha track density using a semiconductor detector 

    E-print Network

    Hamilton, Ian Scott

    1993-01-01

    Determination of the alpha track density in the cellulose nitrate (CN) dielectric version of solid state nuclear track detectors (SSNTD) has traditionally been tedious work which produced results that relied upon the person counting the film as well...

  6. Alpha modification of Tokamak ballooning instabilities

    SciTech Connect

    Spong, D.A.; Leboeuf, J-N.; Holmes, J.A.; Christenson, P.J.

    1989-01-01

    This paper will discuss the high-n ballooning limit (drift resonant effects included in noncircular tokamak geometry) and the hybrid fluid-particle code (inhomogeneous, sheared slab geometry, full FLR alphas, linear and nonlinear).

  7. Alpha Coincidence Spectroscopy studied with GEANT4

    SciTech Connect

    Dion, Michael P.; Miller, Brian W.; Tatishvili, Gocha; Warren, Glen A.

    2013-11-02

    Abstract The high-energy side of peaks in alpha spectra, e.g. 241Am, as measured with a silicon detector has structure caused mainly by alpha-conversion electron and to some extent alphagamma coincidences. We compare GEANT4 simulation results to 241Am alpha spectroscopy measurements with a passivated implanted planar silicon detector. A large discrepancy between the measurements and simulations suggest that the GEANT4 photon evaporation database for 237Np (daughter of 241Am decay) does not accurately describe the conversion electron spectrum and therefore was found to have large discrepancies with experimental measurements. We describe how to improve the agreement between GEANT4 and alpha spectroscopy for actinides of interest by including experimental measurements of conversion electron spectroscopy into the photon evaporation database.

  8. Radioimmunotherapy with alpha-particle emitting radionuclides.

    PubMed

    Zalutsky, M R; Pozzi, O R

    2004-12-01

    An important consideration in the development of effective strategies for radioimmunotherapy is the nature of the radiation emitted by the radionuclide. Radionuclides decaying by the emission of alpha-particles offer the possibility of matching the cell specific reactivity of monoclonal antibodies with radiation with a range of only a few cell diameters. Furthermore, alpha-particles have important biological advantages compared with external beam radiation and beta-particles including a higher biological effectiveness, which is nearly independent of oxygen concentration, dose rate and cell cycle position. In this review, the clinical settings most likely to benefit from alpha-particle radioimmunotherapy will be discussed. The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized. PMID:15640792

  9. Nuclear diagnostic for fast alpha particles

    DOEpatents

    Grisham, L.R.; Post, D.E. Jr.; Dawson, J.M.

    1983-11-23

    This invention relates generally to high energy confined plasmas and more particularly is directed to measuring the velocity distribution of confined energetic alpha particles resulting from deuterium-tritium fusion reactions in a confined energetic plasma.

  10. Alpha particles in effective field theory

    SciTech Connect

    Caniu, C.

    2014-11-11

    Using an effective field theory for alpha (?) particles at non-relativistic energies, we calculate the strong scattering amplitude modified by Coulomb corrections for a system of two ?s. For the strong interaction, we consider a momentum-dependent interaction which, in contrast to an energy dependent interaction alone [1], could be more useful in extending the theory to systems with more than two ? particles. We will present preliminary results of our EFT calculations for systems with two alpha particles.

  11. Monitoring pipes for residual alpha contamination

    SciTech Connect

    MacArthur, D.; Rawool-Sullivan, M.; Dockray, T.

    1996-12-31

    The sensitivity and application of traditional alpha monitors is limited by the short range of alpha particles in air (typically 10 cm) and in solid materials (typically tens of {mu}m). Detecting small amounts of alpha-emitting contamination inside pipes presents particular problems. The alpha particle cannot penetrate the walls of the pipe. Associated gamma-ray detection and active neutron interrogation is often used to detect large amounts of radioactive material in pipes, but these methods are of limited use for detecting small amounts of contamination. Insertion of traditional alpha probes works well in large-diameter straight, pipes, but is increasingly difficult as the pipe network becomes smaller in diameter and more complex. Monitors based on long-range alpha detection (LRAD) detect ionization of the ambient air rather than the alpha particles themselves. A small fan draws the ions into an externally mounted ion detector. Thus, the air in the pipe serves as both the detector gas and the mechanism for transporting the alpha-induced ions to a detection grid outside of the pipe. All of the ions created by all of the contamination in the pipe can be measured in a single detector. Since ambient air serves as the {open_quotes}probe,{close_quotes} crushed or twisted sections of pipe can be monitored almost as effectively as straight sections. The pipe monitoring system described in this paper was tested both at Los Alamos and at BNFL`s Sellafield reprocessing facility in the UK. In this paper, the authors report on the first field tests of the pipe monitoring system.

  12. Alpha-emitters for medical therapy workshop

    SciTech Connect

    Feinendegen, L.E.; McClure, J.J.

    1996-12-31

    A workshop on ``Alpha-Emitters for Medical Therapy`` was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference.

  13. Transport of Radioactive Material by Alpha Recoil

    SciTech Connect

    Icenhour, A.S.

    2005-05-19

    The movement of high-specific-activity radioactive particles (i.e., alpha recoil) has been observed and studied since the early 1900s. These studies have been motivated by concerns about containment of radioactivity and the protection of human health. Additionally, studies have investigated the potential advantage of alpha recoil to effect separations of various isotopes. This report provides a review of the observations and results of a number of the studies.

  14. Alpha particles in effective field theory

    NASA Astrophysics Data System (ADS)

    Caniu, C.

    2014-11-01

    Using an effective field theory for alpha (?) particles at non-relativistic energies, we calculate the strong scattering amplitude modified by Coulomb corrections for a system of two ?s. For the strong interaction, we consider a momentum-dependent interaction which, in contrast to an energy dependent interaction alone [1], could be more useful in extending the theory to systems with more than two ? particles. We will present preliminary results of our EFT calculations for systems with two alpha particles.

  15. Efficiency of natural phenolic compounds regenerating alpha-tocopherol from alpha-tocopheroxyl radical.

    PubMed

    Pazos, Manuel; Andersen, Mogens L; Medina, Isabel; Skibsted, Leif H

    2007-05-01

    Benzoic acid-derived phenolics (p-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, vanillic acid, syringic acid, and gallic acid) and the polyphenols epicatechin and epigallocatechin gallate (EGCG) were evaluated for their efficiency in regenerating alpha-tocopherol from alpha-tocopheroxyl radical in comparison with ascorbyl palmitate, which is known to regenerate alpha-tocopherol. Ethanolic solutions of phenolic compounds were added to a homogeneous hexane medium containing alpha-tocopheroxyl radical generated by reaction of alpha-tocopherol in molar excess with 1,1-diphenyl-2-picrylhydrazyl radical, and the alpha-tocopheroxyl radical was monitored by electron spin resonance spectroscopy. p-Hydroxybenzoic acid, vanillic acid, and syringic acid (400 microM) did not exhibit a significant effect on alpha-tocopheroxyl radical concentration (0.6-0.7 microM). In contrast, 3,4-dihydroxybenzoic acid and gallic acid were able to reduce the concentration of alpha-tocopheroxyl radical by 16 and 64%, respectively. Epicatechin showed a reduction of alpha-tocopheroxyl radical similar to gallic acid, and EGCG and ascorbyl palmitate were the most effective, reducing alpha-tocopheroxyl radical completely at a much lower phenolic concentration (66.7 microM). The moles of alpha-tocopheroxyl radical reduced per mole of ascorbyl palmitate (0.93), EGCG (0.066), gallic acid (4.3 x 10(-4)), and epicatechin (4.5 x 10(-4)) were determined, and the logarithm of these stoichoimetric ratios showed a negative linear relationship with the bond dissociation enthalpies of the O-H bond of the phenolics. The relative capacity to reduce alpha-tocopheroxyl radical was found to be ascorbyl palmitate (2142) > EGCG (151) > gallic acid (1) approximately epicatechin (1). PMID:17419638

  16. Refinement of the neutron-alpha and proton-alpha fish-bone potential

    NASA Astrophysics Data System (ADS)

    Smith, Eric S.

    The non-local fish-bone potential simulates the Pauli-exclusion principle for composite particle interactions. This model is used to calculate the phase shifts of the neutron-alpha and proton-alpha systems. We propose a local double Gaussian potential with a new parameterization by fitting to experimental results. These parameters are universal to both nucleon-alpha systems and include all partial waves, which is an improvement over previous work in the field.

  17. Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase.

    PubMed

    McDougall, Gordon J; Shpiro, Faina; Dobson, Patricia; Smith, Pauline; Blake, Alison; Stewart, Derek

    2005-04-01

    Polyphenol-rich extracts from soft fruits were tested for their ability to inhibit alpha-amylase and alpha-glucosidase. All extracts tested caused some inhibition of alpha-amylase, but there was a 10-fold difference between the least and most effective extracts. Strawberry and raspberry extracts were more effective alpha-amylase inhibitors than blueberry, blackcurrant, or red cabbage. Conversely, alpha-glucosidase was more readily inhibited by blueberry and blackcurrant extracts. The extent of inhibition of alpha-glucosidase was related to their anthocyanin content. For example, blueberry and blackcurrant extracts, which have the highest anthocyanin content, were the most effective inhibitors of alpha-glucosidase. The extracts most effective in inhibiting alpha-amylase (strawberry and raspberry) contain appreciable amounts of soluble tannins. Other tannin-rich extracts (red grape, red wine, and green tea) were also effective inhibitors of alpha-amylase. Indeed, removing tannins from strawberry extracts with gelatin also removed inhibition. Fractionation of raspberry extracts on Sephadex LH-20 produced an unbound fraction enriched in anthocyanins and a bound fraction enriched in tannin-like polyphenols. The unbound anthocyanin-enriched fraction was more effective against alpha-glucosidase than the original extract, whereas the alpha-amylase inhibitors were concentrated in the bound fraction. The LH-20 bound sample was separated by preparative HPLC, and fractions were assayed for inhibition of alpha-amylase. The inhibitory components were identified as ellagitannins using LC-MS-MS. This study suggests that different polyphenolic components of fruits may influence different steps in starch digestion in a synergistic manner. PMID:15796622

  18. Preparation and properties of (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-( sup 125 I)iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-( sup 125 I)iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals

    SciTech Connect

    Cohen, V.I.; Rzeszotarski, W.J.; Gibson, R.E.; Fan, L.H.; Reba, R.C. )

    1989-10-01

    rac-4-Nitrobenzilic acid was synthesized and resolved with quinidine and quinine to give the corresponding (R)- and (S)-salts. The resolved diastereomeric salts were converted to (R)- and (S)-4-nitrobenzilic acids and subsequent esterification gave their corresponding ethyl esters. Transesterification with (R)-(-)-3-quinuclidinol afforded (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(R)-(+)-alpha-hydroxy-alpha- (4-nitrophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(S)-(-)-alpha-hydroxy- alpha-(4-nitrophenyl)-alpha-phenyl acetate. After hydrogenation, the (R,R)- and (R,S)-amines were converted to the respective triazene derivatives. The triazene derivatives reacted with sodium ({sup 125}I)iodide to give (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(R)-(+)- alpha-hydroxy-alpha-(4-({sup 125}I)iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(S)-(-)-alpha-hydroxy- alpha-(4-(125I)iodophenyl)-alpha-phenyl acetate. The evaluation of their affinities to muscarinic acetylcholine receptors (MAcChR) shows that (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(S)-(-)-alpha-hydroxy-alpha-(4- ({sup 125}I)iodophenyl)-alpha-phenyl acetate exhibits an affinity for the MAcChR from corpus striatum that is approximately threefold lower than that of (R)-(-)-1-azabicyclo(2.2.2)oct-3-yl-(R)-(+)-alpha-hydroxy-alpha-(4- ({sup 125}I)iodophenyl)-alpha-phenyl acetate.

  19. Alpha-dispersion in human tissue

    NASA Astrophysics Data System (ADS)

    Grimnes, Sverre; Martinsen, Ørjan G.

    2010-04-01

    Beta dispersion is found in living tissue in the kilohertz - megahertz range and is caused by the cellular structure of biological materials with low frequency properties caused by cell membranes. Alpha dispersion is found in the hertz range and the causes are not so well known. Alpha dispersions are the first to disappear when tissue dies. Tissue data have often been based upon excised specimen from animals and are therefore not necessarily representative for human tissue alpha dispersions. Here we present data obtained with non-invasive skin surface electrodes for different segments of the living human body. We found alpha dispersions in all cases; the ankle-wrist results had the smallest. Large alpha dispersions were found where the distance between the electrodes and muscle masses was small, e.g. on the calf. Further studies on electrode technique and reciprocity, electrode positioning, statistical variations, gender, age and bodily constitutions are necessary in order to reveal more about the alpha dispersion, its appearance and disappearance.

  20. Structures of G [alpha [superscript i1

    SciTech Connect

    Johnston, Christopher A.; Willard, Francis S.; Jezyk, Mark R.; Fredericks, Zoey; Bodor, Erik T.; Jones, Miller B.; Blaesius, Rainer; Watts, Val J.; Harden, T. Kendall; Sondek, John; Ramer, J. Kevin; Siderovski, David P.

    2010-07-19

    Heterotrimeric G proteins are molecular switches that regulate numerous signaling pathways involved in cellular physiology. This characteristic is achieved by the adoption of two principal states: an inactive, GDP bound state and an active, GTP bound state. Under basal conditions, G proteins exist in the inactive, GDP bound state; thus, nucleotide exchange is crucial to the onset of signaling. Despite our understanding of G protein signaling pathways, the mechanism of nucleotide exchange remains elusive. We employed phage display technology to identify nucleotide state-dependent G{alpha} binding peptides. Herein, we report a GDP-selective G{alpha} binding peptide, KB-752, that enhances spontaneous nucleotide exchange of G{alpha}{sub i} subunits. Structural determination of the G{alpha}{sub i1}/peptide complex reveals unique changes in the G{alpha} switch regions predicted to enhance nucleotide exchange by creating a GDP dissociation route. Our results cast light onto a potential mechanism by which G{alpha} subunits adopt a conformation suitable for nucleotide exchange.

  1. Folding model analysis of alpha radioactivity

    E-print Network

    D. N. Basu

    2003-07-29

    Radioactive decay of nuclei via emission of $\\alpha$ particles has been studied theoretically in the framework of a superasymmetric fission model using the double folding (DF) procedure for obtaining the $\\alpha$-nucleus interaction potential. The DF nuclear potential has been obtained by folding in the density distribution functions of the $\\alpha$ nucleus and the daughter nucleus with a realistic effective interaction. The M3Y effective interaction has been used for calculating the nuclear interaction potential which has been supplemented by a zero-range pseudo-potential for exchange along with the density dependence. The nuclear microscopic $\\alpha$-nucleus potential thus obtained has been used along with the Coulomb interaction potential to calculate the action integral within the WKB approximation. This subsequently yields microscopic calculations for the half lives of $\\alpha$ decays of nuclei. The density dependence and the exchange effects have not been found to be very significant. These calculations provide reasonable estimates for the lifetimes of $\\alpha$ radioactivity of nuclei.

  2. Alpha particle analysis using PEARLS spectrometry

    SciTech Connect

    McKlveen, J.W.; Klingler, G.W.; McDowell, W.J.; Case, G.N.

    1984-01-01

    Alpha particle assay by conventional plate-counting methods is difficult because chemical separation, tracer techniques, and/or self-absorption losses in the final sample may cause either non-reproducible results or create unacceptable errors. PEARLS (Photon-Electron Rejecting Alpha Liquid Scintillation) Spectrometry is an attractive alternative since radionuclides may be extracted into a scintillator in which there would be no self-absorption or geometry problems and in which up to 100% chemical recovery and counting efficiency is possible. Sample preparation may include extraction of the alpha emitter of interest by a specific organic-phase-soluble compound directly into the liquid scintillator. Detection electronics use energy and pulse-shape discrimination to provide discrete alpha spectra and virtual absence of beta and gamma backgrounds. Backgrounds on the order of 0.01 cpm are readily achievable. Accuracy and reproducibility are typically in the 100 +-1% range. Specific procedures have been developed for gross alpha, uranium, plutonium, thorium, and polonium assay. This paper will review liquid scintillation alpha counting methods and reference some of the specific applications. 8 refs., 1 fig.

  3. Kurzbericht ber die formative Evaluation des Lehrmittels Mathematik Primarstufe

    E-print Network

    Steiner, Daniel

    Kurzbericht über die formative Evaluation des Lehrmittels «Mathematik Primarstufe» «Das ist für CH-8090 Zürich Zürcher Fachhochschule Juli 2013 #12;Kurzbericht über die formative Evaluation des Lehrmittels «Mathematik Primarstufe» 2PH Zürich| Vorwort Dieser Bericht möchte Lehrpersonen über die

  4. Bemerkungen zu einem gewissen Auszug des Descartes, der sich auf

    E-print Network

    Leonhard Euler In den Auszügen aus den Manuskripten von Descartes wird zwar in we- nigen Worten eine Rahmen des Projektes ,,Euler-Kreis Mainz" 1 #12;dem vierten Teil des vorhergehenden; und auf dieselbe

  5. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  6. Systemtherapie des metastasierten malignen Melanoms.

    PubMed

    Rauschenberg, Ricarda; Garzarolli, Marlene; Dietrich, Ursula; Beissert, Stefan; Meier, Friedegund

    2015-12-01

    Für Patienten mit metastasiertem Melanom stehen aktuell mehrere wirksame Therapieoptionen zur Verfügung. Die BRAF-Inhibitoren Vemurafenib und Dabrafenib zeichnen sich durch eine rasche Tumorkontrolle und hohe Ansprechraten aus. In Kombination mit den MEK-Inhibitoren Trametinib bzw. Cobimetinib erreichen sie Ansprechraten (CR + PR, komplette plus partielle Remissionen) von 70 %, wobei die Entwicklung einer Therapieresistenz verzögert wird, sowie ein medianes Gesamtüberleben von > 2 Jahren bei tolerablen Nebenwirkungen. Der CTLA-4-Antikörper Ipilimumab erzielte für Patienten mit metastasiertem Melanom als erste Substanz eine signifikante Verlängerung des Gesamtüberlebens (Langzeitüberlebensrate: 20-26 %). Verzögertes Therapieansprechen und schwere immunvermittelte Nebenwirkungen können den therapeutischen Benefit einschränken. Die Monotherapie mit den PD-1-Antikörpern Nivolumab oder Pembrolizumab erreicht Ansprechraten (CR + PR) bis zu 45 % und 1-Jahres-Überlebensraten von > 70 % bei meist guter Verträglichkeit. Die Kombination Ipilimumab plus Nivolumab zeigte Ansprechraten bis zu 58 % und ein medianes progressionsfreies Überleben von > 11 Monaten. Von dieser Kombination wird ein zeitnahes und lang anhaltendes Ansprechen erwartet. Dieser potenzielle Benefit wird durch eine hohe Toxizität erkauft. Aktuell werden in klinischen Studien Strategien für Therapiesequenz und -kombinationen geprüft. Insgesamt hat sich die Prognose für Patienten mit metastasiertem Melanom signifikant verbessert. In Anbetracht eines möglichen Langzeitüberlebens müssen neben akuten Nebenwirkungen auch die Langzeit-Nebenwirkungen einer Behandlung berücksichtigt werden. PMID:26612790

  7. The Lyman alpha reference sample. VII. Spatially resolved H$\\alpha$ kinematics

    E-print Network

    Herenz, Edmund Christian; Orlitova, Ivana; Hayes, Matthew; Östlin, Göran; Cannon, John M; Roth, Martin M; Bik, Arjan; Pardy, Stephen; Otí-Floranes, Héctor; Mas-Hesse, J Miguel; Adamo, Angela; Atek, Hakim; Duval, Florent; Guaita, Lucia; Kunth, Daniel; Laursen, Peter; Melinder, Jens; Puschnig, Johannes; Rivera-Thorsen, Thøger E; Schaerer, Daniel; Verhamme, Anne

    2015-01-01

    We present integral field spectroscopic observations with the Potsdam Multi Aperture Spectrophotometer of all 14 galaxies in the $z\\sim 0.1$ Lyman Alpha Reference Sample (LARS). We produce 2D line of sight velocity maps and velocity dispersion maps from the Balmer $\\alpha$ (H$\\alpha$) emission in our data cubes. These maps trace the spectral and spatial properties of the LARS galaxies' intrinsic Ly$\\alpha$ radiation field. We show our kinematic maps spatially registered onto the Hubble Space Telescope H$\\alpha$ and Lyman $\\alpha$ (Ly$\\alpha$) images. Only for individual galaxies a causal connection between spatially resolved H$\\alpha$ kinematics and Ly$\\alpha$ photometry can be conjectured. However, no general trend can be established for the whole sample. Furthermore, we compute non-parametric global kinematical statistics -- intrinsic velocity dispersion $\\sigma_0$, shearing velocity $v_\\mathrm{shear}$, and the $v_\\mathrm{shear}/\\sigma_0$ ratio -- from our kinematic maps. In general LARS galaxies are charac...

  8. Methods for the synthesis and polymerization of .alpha.,.alpha.'-dihalo-p-xylenes

    DOEpatents

    Ferraris, John P. (Coppell, TX); Neef, Charles J. (Garland, TX)

    2002-07-30

    The present invention describes an improved method for the polymerization of .alpha.,.alpha.-dihalo-p-xylene's such as the .alpha.,.alpha.'-dihalo-2-methoxy-5-(2-ethylhexyloxy)-xylene's. The procedure for synthesis is based on the specific order of addition of reagents and the use of an anionic initiator that allows control of the molecular weight of the polymer. The molecular weight control allows processability of the polymer which is important for its utility in applications including in light-emitting-diodes, field effect transistors and photovoltaic devices.

  9. Order alpha_s^2 magnetic penguin correction for B decay to light mesons

    E-print Network

    C. S. Kim; Yeo Woong Yoon

    2012-05-15

    We compute the order alpha_s^2 correction to the matrix element of magnetic penguin operator for B meson decaying to light mesons within the QCD factorization framework. We explicitly show that the soft and collinear divergences are canceled out, so that the validity of QCD factorization is confirmed. We present the result of the calculation in complete analytic forms. The result is also applied to B -> K pi decays, and we find that the order alpha_s^2 correction of magnetic penguin operator can considerably reduce the coefficient of penguin amplitude a^c_{4,I}. The reduction is stronger for the imaginary part.

  10. Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS.

    PubMed Central

    Brune, J L; Yang, F; Barnett, D R; Bowman, B H

    1984-01-01

    Haptoglobin is a transport glycoprotein which removes free hemoglobin from the circulation of vertebrates. In human populations haptoglobin is polymorphic due to three alleles, Hp alpha 1F, Hp alpha 1S and Hp alpha 2. The Hp alpha 2 allele is roughly twice the length of the Hp alpha 1 alleles and is the product of a partial gene duplication possibly resulting from an unequal crossover event in a heterozygous genotype Hp alpha 1F/Hp alpha 1S. In the study described here we compare the cDNA encoding Hp alpha 1S to that encoding Hp alpha 2FS . Both have a leader sequence followed by the genotypic alpha chain sequence, a beta sequence and an untranslated sequence in the 3' end. The cDNA encoding Hp alpha 2FS is composed of alpha 1F and alpha 1S domains differing by four nucleotide replacements. Hp alpha 1S cDNA contains the same replacement site mutations found in the alpha 1S domain of Hp alpha 2FS , indicating that this coding region has sustained few, if any, mutations since its incorporation into the Hp alpha 2FS gene. Images PMID:6330675

  11. Profil epidemiologique des brulures d'enfants admis au Centre National des Brules, Maroc

    PubMed Central

    Zahid, A.; Atannaz, J.; Alaoui, M.; Rafik, A.; Ezzoubi, M.; Diouri, M.; Chlihi, A.; Bahechar, N.; Boukind, E.H.

    2011-01-01

    Summary Ce travail rétrospectif analyse les particularités épidémiologiques de 543 cas de brûlures d'enfants, représentant 45,7% des admissions de notre centre, en vue de déterminer les éléments pouvant contribuer à renforcer la prévention, qui reste le traitement de choix de cette pathologie. La moyenne d'âge est de 4,25 ans avec une prédilection pour la tranche d'âge d'un à cinq ans, avec 42,5% des cas. Une atteinte masculine est retrouvée dans 63,5% des cas. La brûlure survient à domicile dans 85,1% et accidentellement dans 95% des cas. Les brûlures thermiques représentent 96,5% des causes dominées par les liquides dans 69,3% des cas. La surface cutanée brûlée est ? 20% dans 52,3%. La brûlure intéresse essentiellement les membres supérieurs (79,1%). 56,8% des enfants sont transférés par d'autres hôpitaux et le délai de prise en charge hospitalière est supérieur à 6 heures dans 65,5%. Le taux de mortalité a été de 13,2%. PMID:22639559

  12. Alpha Com eclipse observing campaign

    NASA Astrophysics Data System (ADS)

    Waagen, Elizabeth O.

    2014-12-01

    Drs. Matthew W. Muterspaugh and Gregory W. Henry (Tennessee State University) have requested AAVSO observers' ssistance in monitoring the possible Algol-like binary star alpha Com before, during, and after the eclipse they have predicted for mid-to-late January 2015. The PIs will be using the Fairborn Observatory automated photometric telescopes on Mt. Hopkins, but they are requesting additional observations not only to supplement theirs but also specifically to have good coverage in the event of bad weather at Mt. Hopkins. Alf Com has a 26-year period and is 4.32V at maximum. The expected amplitude of the eclipse is about 0.8 magnitude and the duration somewhere between 28 and 45 hours. The eclipse is predicted for January 25 ± three days (JD 2457047 ± 3). Muterspaugh at al. first calculated the possibility of a 2015 eclipse in 2010 (AJ). Muterspaugh and Henry recently published an article with updated information (arXiv 2014). V and/or R photometry (other bands welcome) is requested, with a minimal cadence of one measurement/2 hours, to make sure the eclipse is caught right as it begins and to ensure having multiple data points on any unseen objects that might eclipse as well. During eclipse, continuous observations are important. Infrared (H-band) observations could be interesting, should the CHARA array image the event. The precision photometry in the weeks before and after the eclipse is requested in order to catch possible evidence for planets or other materials around the eclipsing star. Updated astrometry from the current epoch would greatly improve the eclipse preductions. Charts with comparison star sequence for alf Com may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). The PIs recommend using the comparison stars HD 113848 (39 Com, HR 4946, HIP 63948, V=5.990, B-V=0.39, F4V) and HD 114520 (HIP 64312, V=6.820, B-V=0.46,F2II). Observations should be submitted to the AAVSO International Database. See AAVSO Alert Notice 506 for full details.

  13. Vice-dcanat la recherche Rpertoire des projets

    E-print Network

    Laval, Université

    ........................................................................................................................ 22 Département des sciences des aliments et nutrition projet Contrat - Ministère de l'agriculture, des pêcheries et de l'alimentation - 2011-03-15 au 2011 et de l'alimentation GQ098515 CC 11 000,00$ Financement global 11 000,00$ LAMBERT, Rémy Projet

  14. JARDIN DES PLANTES 57 RUE CUVIER, PARIS 5e

    E-print Network

    des adaptations humaines, en termes de locomotion et d'alimentation, au cours de l'évolution. Celles. 2. Alimentation et digestion. Diversité des régimes alimentaires et des niches écologiques, saisonnalité, alimentation et santé. Coévolution avec les plantes, automédication. 3. Comportement, vie sociale

  15. Accs au texte intgral des articles depuis Lyon1

    E-print Network

    Maume-Deschamps, Véronique

    Accès au texte intégral des articles depuis Lyon1 Accès au texte intégral par le résolveur de liens résolveur de liens en cliquant sur l'une des icônes : 1 #12;Accès au texte intégral des articles depuis Lyon texte intégral d'un article / portail de la BU 3 Référence de l'article Titre de la revue Site web de la

  16. www.cnrs.fr Des virus mergents aux virus pandmiques

    E-print Network

    van Tiggelen, Bart

    JACQUES-MONOD Institut des sciences biologiques Institut écologie et environnement Information Secrétariat des Conférences Jacques-Monod CNRS Institut des sciences biologiques 3, rue Michel-Ange, F-75794 Paris Cedex 16, France E-mail : conf.monod@cnrs-dir.fr http://www.cnrs.fr/insb/cjm/ #12;

  17. PLC IMPLEMENTATION OF A DES SUPERVISOR FOR A MANUFACTURING

    E-print Network

    Leduc, Ryan

    PLC IMPLEMENTATION OF A DES SUPERVISOR FOR A MANUFACTURING TESTBED: AN IMPLEMENTATION PERSPECTIVE Copyright by Ryan James Leduc 1996 #12;Title: PLC Implementation of A DES Supervisor for a Manufacturing, and issues involved in implementing DES supervisors on programmable logic controllers (PLC). A PLC based

  18. Geschftsordnung des Audit Committees der Universitt Zrich Geschftsordnung

    E-print Network

    Zürich, Universität

    Geschäftsordnung des Audit Committees der Universität Zürich Geschäftsordnung des Audit Committee der Universität Zürich (vom 20. August 2007) § 1 Ziel und Zweck Das Audit Committee unterstützt den Revision führt im Auftrag des Audit Committee die Revisionen durch. Sie ist fachlich dem Audit Committee

  19. 0. Informationen zur Vorlesung 0-1 Grundlagen des

    E-print Network

    Brass, Stefan

    . Stefan Brass Institut f¨ur Informatik ¨Ubungen: Dr. Henning Thielemann Stefan Brass: Grundlagen des World) · Suchmaschinen (kurz) Stefan Brass: Grundlagen des World Wide Web Universit¨at Halle, 2009 #12;0. Informationen Brass: Grundlagen des World Wide Web Universit¨at Halle, 2009 #12;0. Informationen zur Vorlesung 0

  20. 0. Informationen zur Vorlesung 0-1 Grundlagen des

    E-print Network

    Brass, Stefan

    . Stefan Brass Institut f¨ur Informatik ¨Ubungen: Dr. Henning Thielemann Stefan Brass: Grundlagen des World) · Suchmaschinen (kurz) Stefan Brass: Grundlagen des World Wide Web Universit¨at Halle, 2010 #12;0. Informationen Brass: Grundlagen des World Wide Web Universit¨at Halle, 2010 #12;0. Informationen zur Vorlesung 0

  1. Autour des services web Georges-Andr SILBER

    E-print Network

    Silber, Georges-André

    structures. #12;L'invention du Web · 1989:Tim Berners-Lee travaille au CERN et invente le Web · 1994'art des technologies Web : description- egypte.org #12;Tim Berners-Lee · Le père du WWW · Inventeur des de Tim en 1990 sur un ordinateur NeXT #12;HTML · Création d'un nouveau langage pour représenter des

  2. Recent advances in the discovery of alpha1-adrenoceptor agonists.

    PubMed

    Bishop, Michael J

    2007-01-01

    The alpha(1) adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the alpha(1) adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known alpha(1) adrenoceptor agonists are alpha(1A) selective, but the discovery of highly selective alpha(1B) and alpha(1D) adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific alpha(1) agonists as well as contributions to our understanding of agonist-receptor interactions. PMID:17266602

  3. Overview Of Suborbital Human Transportation Concept Alpha

    NASA Astrophysics Data System (ADS)

    Adirim, H.; Pilz, N.; Marini, M.; Hendrick, P.; Schmid, M.; Behr, R.; Barth, T.; Tarfeld, F.; Wiegand, A.; Charbonnier, D.; Haya Ramos, R.; Steeland, J.; Mack, A.

    2011-05-01

    Within the EC co-funded project FAST20XX (Future high-Altitude high-Speed Transport 20XX), the European suborbital passenger transportation system concept ALPHA (Airplane Launched PHoenix Aircraft), which shall be based to a maximum extent on existing technologies and capabilities, is currently being investigated as collaborative project by a European consortium under coordination of ESA. The ALPHA concept incorporates an air-launch from a carrier aircraft, which shall be used as first stage. The ALPHA vehicle shall be capable of transporting up to four passengers plus one pilot to an altitude of at least 100 km. The ALPHA vehicle is a down-scaled version of the suborbital space transportation concept Hopper, which was already deeply investigated within the European FESTIP System Study and the German ASTRA program including the successfully flown experimental landing demonstrator Phoenix. This approach has allowed the use of existing aerodynamic vehicle data and has led to the adaptation of the external Hopper/Phoenix configuration for ALPHA. In FESTIP and ASTRA, the Hopper configuration showed sufficient stability margins. Due to the geometric similarity of the ALPHA and Hopper vehicles, a trimable and flyable configuration could be derived by means of ALPHA flight trajectory calculations. In its current configuration, the ALPHA vehicle has a length of ca. 9 m and a gross take-off mass of ca. 3.5 Mg. The launch, staging and separation of ALPHA shall be performed either as internal air-launch from the cargo bay of the carrier aircraft, as under-wing air-launch or as towed air-launch. After separation from the carrier aircraft, the ALPHA vehicle ignites its onboard rocket propulsion system. Since conventional liquid and solid propulsion did not seem suitable for ALPHA due to Their high cost, limited safety and toxicity, a low-cost, “green” and non-hazardous hybrid propulsion system based on liquid nitrous oxide in combination with a solid polymer fuel was selected as baseline ALPHA propulsion. The general feasibility of hybrid propulsion for suborbital vehicle application with this propellant combination was already successfully demonstrated in the first reusable and privately-funded manned launch vehicle SpaceShipOne and consequently represents the solution with the lowest development risk for the investigated application. Due to the huge success of SpaceShipOne, the same type of hybrid propulsion is foreseen for Virgin Galactic’s SpaceShipTwo. ALPHA vehicle guidance will preferably be fully autonomous during the entire mission flight profile. The required technology for autonomous vehicle guidance can be adapted from the European RLV demonstrator Phoenix, which successfully demonstrated automated landing when it was dropped three times by a helicopter and landed precisely after a GPS-guided glide. This paper outlines the current status of the technology development work for ALPHA and has a special focus on aerodynamic and aerothermodynamic aspects of the concept.

  4. Pharmacologic specificity of alpha-2 adrenergic receptor subtypes

    SciTech Connect

    Petrash, A.; Bylund, D.

    1986-03-01

    The authors have defined alpha-2 adrenergic receptor subtypes in human and rat tissues using prazosin as a subtype selective drug. Prazosin has a lower affinity (250 nM) at alpha-2A receptor and a higher affinity (5 nM) at alpha-2B receptors. In order to determine if other adrenergic drugs are selective for one or the other subtypes, the authors performed (/sup 3/H)yohimbine inhibition experiments with various adrenergic drugs in tissues containing alpha-2A, alpha-2B or both subtypes. Oxymetazoline, WB4101 and yohimbine were found to be 80-, 20- and 10-fold more potent at alpha-2A receptors than at alpha-2B receptors. Phentolamine, adazoxan, (+)- and (-)-mianserin, clonidine, (+)-butaclamol, (-)- and (+)-norepinephrine, epinephrine, dopamine and thioridazine were found to have equal affinities for the two subtypes. These results further validate the subdivision of alpha-2 adrenergic receptors into alpha-2A and alpha-2B subtypes.

  5. Cancer radioimmunotherapy with alpha-emitting nuclides.

    PubMed

    Couturier, Olivier; Supiot, Stéphane; Degraef-Mougin, Marie; Faivre-Chauvet, Alain; Carlier, Thomas; Chatal, Jean-François; Davodeau, François; Cherel, Michel

    2005-05-01

    In lymphoid malignancies and in certain solid cancers such as medullary thyroid carcinoma, somewhat mixed success has been achieved when applying radioimmunotherapy (RIT) with beta-emitters for the treatment of refractory cases. The development of novel RIT with alpha-emitters has created new opportunities and theoretical advantages due to the high linear energy transfer (LET) and the short path length in biological tissue of alpha-particles. These physical properties offer the prospect of achieving selective tumoural cell killing. Thus, RIT with alpha-emitters appears particularly suited for the elimination of circulating single cells or cell clusters or for the treatment of micrometastases at an early stage. However, to avoid non-specific irradiation of healthy tissues, it is necessary to identify accessible tumoural targets easily and rapidly. For this purpose, a small number of alpha-emitters have been investigated, among which only a few have been used for in vivo preclinical studies. Another problem is the availability and cost of these radionuclides; for instance, the low cost and the development of a reliable actinium-225/bismuth-213 generator were probably determining elements in the choice of bismuth-213 in the only human trial of RIT with an alpha-emitter. This article reviews the literature concerning monoclonal antibodies radiolabelled with alpha-emitters that have been developed for possible RIT in cancer patients. The principal radio-immunoconjugates are considered, starting with physical and chemical properties of alpha-emitters, their mode of production, the possibilities and difficulties of labelling, in vitro studies and finally, when available, in vivo preclinical and clinical studies. PMID:15841373

  6. Checkliste: ERASMUS+, Dozentenmobilitt wei = Schritte des IO bzw. der ZUV orange = Schritte des/der Dozenten/-in

    E-print Network

    Meise, Reinhold

    Checkliste: ERASMUS+, Dozentenmobilität weiß = Schritte des IO bzw. der ZUV orange = Schritte des\\Dozentenmobilität\\Dozentenmobilität_STA_14_15\\Dozentenmobilität_Checkliste_2014_2015 Phasen wann?/ Frist was? wer? an wen? Formular, Dienstreisegenehmigung #12;Checkliste: ERASMUS+, Dozentenmobilität weiß = Schritte des IO bzw. der ZUV orange = Schritte

  7. Une unit motivante pour la mesure des aires : la fraise tagada ! Etude des rectangles de primtre 36 cm

    E-print Network

    Pansu, Pierre

    Une unité motivante pour la mesure des aires : la fraise tagada ! Etude des rectangles de périmètre plus grande aire. Etude des rectangles d'aire 36 cm² Propriété démontrée graphiquement : parmi tous les rectangles d'aire 36 cm², le carré est celui qui a le plus petit périmètre. Quadrilatères articulés Un défi

  8. Index des notations Certaines notations sont utilis'ees dans diff'erents domaines avec des significations dis

    E-print Network

    Ollivier, François

    le contexte des ensembles cract'eristiques) : p. 91. HC (C un ensemble de polynâ??omes diff'erentiels) : p. 93. AE C (C un ensemble de polynâ??omes diff'erentiels) : p. 93. C(`) (` un vecteur de paramIndex des notations Certaines notations sont utilis'ees dans diff'erents domaines avec des

  9. Piper Alpha and Independence Marion King Hubbert (1903 1989) Piper Alpha (6 July 1988)

    E-print Network

    be a second Piper Alpha tragedy for Scotland if its historical effect on oil production has not been by the Yes campaign. Following Piper Alpha, oil production was deliberately cut back in order to allow the installation of new safety measures. As a result UK peak oil was delayed by 10 years. Once due allowance

  10. Radiative-nonrecoil corrections of order alpha^2 (Z alpha)^5 to the Lamb shift

    E-print Network

    Matthew Dowling; Jorge Mondejar; Jan H. Piclum; Andrzej Czarnecki

    2010-05-11

    We present results for the corrections of order alpha^2 (Z alpha)^5 to the Lamb shift. We compute all the contributing Feynman diagrams in dimensional regularization and a general covariant gauge using a mixture of analytical and numerical methods. We confirm results obtained by other groups and improve their precision. Values of the 32 master integrals for this and similar problems are provided.

  11. Experimental and Theoretical Electron Density Distribution of Alpha,Alpha-Trehalose Dihydrate

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Alpha,alpha-rehalose is of interest because of its cryoprotective and antidessicant properties, and because it possesses various technical anomalies such as 13C NMR spectra that give misleading indications of intramolecular structural symmetry. It is a non-reducing disaccharide, with the glycosidic...

  12. Amyloid formation and disaggregation of {alpha}-synuclein and its tandem repeat ({alpha}-TR)

    SciTech Connect

    Bae, Song Yi; Kim, Seulgi; Hwang, Heejin; Kim, Hyun-Kyung; Yoon, Hyun C.; Kim, Jae Ho; Lee, SangYoon; Kim, T. Doohun

    2010-10-01

    Research highlights: {yields} Formation of the {alpha}-synuclein amyloid fibrils by [BIMbF{sub 3}Im]. {yields} Disaggregation of amyloid fibrils by epigallocatechin gallate (EGCG) and baicalein. {yields} Amyloid formation of {alpha}-synuclein tandem repeat ({alpha}-TR). -- Abstract: The aggregation of {alpha}-synuclein is clearly related to the pathogenesis of Parkinson's disease. Therefore, detailed understanding of the mechanism of fibril formation is highly valuable for the development of clinical treatment and also of the diagnostic tools. Here, we have investigated the interaction of {alpha}-synuclein with ionic liquids by using several biochemical techniques including Thioflavin T assays and transmission electron microscopy (TEM). Our data shows a rapid formation of {alpha}-synuclein amyloid fibrils was stimulated by 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [BIMbF{sub 3}Im], and these fibrils could be disaggregated by polyphenols such as epigallocatechin gallate (EGCG) and baicalein. Furthermore, the effect of [BIMbF{sub 3}Im] on the {alpha}-synuclein tandem repeat ({alpha}-TR) in the aggregation process was studied.

  13. Individual upper alpha neurofeedback in ADHD 1 The Effects of Individual Upper Alpha Neurofeedback in

    E-print Network

    Minguez, Javier

    Individual upper alpha neurofeedback in ADHD 1 The Effects of Individual Upper Alpha Neurofeedback in ADHD: An Open-Label Pilot Study C. Escolano · M. Navarro-Gil · J. Garcia-Campayo · M. Congedo · J extensively evaluated in ADHD. However, such protocols do not account for the large EEG het- erogeneity

  14. Correcting Coefficient Alpha for Correlated Errors: Is [alpha][K]a Lower Bound to Reliability?

    ERIC Educational Resources Information Center

    Rae, Gordon

    2006-01-01

    When errors of measurement are positively correlated, coefficient alpha may overestimate the "true" reliability of a composite. To reduce this inflation bias, Komaroff (1997) has proposed an adjusted alpha coefficient, ak. This article shows that ak is only guaranteed to be a lower bound to reliability if the latter does not include correlated…

  15. Effets perturbateurs endocriniens des pesticides organochlores.

    PubMed

    Charlier, C; Plomteux, G

    2002-01-01

    Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism, or to compete with estradiol for binding to the estrogen receptor, it may be possible that these products affect the risk of developing impaired fertility, precocious puberty or some kinds of cancer in man. Le plus ancien récit de lutte contre la pollution remonte à une légende indienne racontant que la divinité Sing-bonga était incommodée par les émanations des fours dans lesquels les Asuras fondaient leurs métaux (1). Evidemment depuis, la problématique n-a cessé de s-accroître et la contamination de la Terre par de nombreux polluants est devenue aujourd-hui un problème majeur de notre Société. La protection de notre environnement est une question capitale qui doit être respectée malgré la pression économique actuelle et qui ne cessera de croître au cours des prochaines années même si l-identification objective et indiscutable de ce qui est essentiel - donc devant être prioritairement garanti sur la planète - est difficile à cerner (2). « Un oiseau en mauvais état ne pond pas de bons oeufs » disait un proverbe grec. Mais ce n-est qu-à partir de la seconde moitié du XXème siècle que les toxicologues ont commencé à identifier les effets qu-avaient entraînés à l-échelle mondiale les pollutions émises aux XIXème siècle sur la faune sauvage et sur le cheptel (3). L-histoire contemporaine des pesticides industriels commence vers 1874 (synthèse des organochlorés) et se poursuit tout au long de ces 2 siècles en passant par la synthèse des organophosphorés (1950), des carbamates (1970) et des pyréthroïdes (1975) (4). Le dichlorodiphényltrichloroéthane (DDT) a été synthétisé pour la première fois par un étudiant en cours de préparation de sa thèse de doctorat : Othmer Zeidler. La production, reprise par les entreprises F.Mayo puis par la Geigy Co. a d-abord intéressé l-armée, puis l-agriculture. Dès la fin de la 2(ème) guerre mondiale, des mises en garde furent lancées à propos des effets nocifs du produit (4). Un déclin des populations de grives, d-aigles chauves, d-orfaies et de mammifères consommateurs de poissons fut constaté à partir des années 50 et dénoncé par Rachel Carson dans son célèbre appel du « Silent Spring » de 1962. Bien qu-il soit interdit en Occident depuis les années 70, ce produit a été tellement utilisé et présente une rémanence si longue qu-une contamination ubiquitaire existe aujourd-hui encore. De plus, ce produit continue à être produit aux USA pour être utilisé à des fins de démoustification dans les pays en voie de développement. Il en va de même de l-Hexachlorobenzène (HCB), un autre organochloré dont l-usage est interdit sous nos latitudes, mais reste fréquent dans d-autres pays. Ces deux exemples indiquent que le problème de la contamination continue à nous concerner, même pour des produits dont l-usage est aujourd-hui strictement réglementé ou interdit. Des effets sur la faune semblent encore actuellement devoir être attribués à ces produits. La diminution de la population des phoques dans la mer de Wadden pourrait être due à la forte contamination en composants organochlorés des poissons dont ces phoques se nourrissent (5). Exposé au DDT et à son métabolite dichlorodiphenyldichloroéthylène (DDE), le Seratherodon mossambicus présente une réduction de la sécrétion de cortisol par une action toxique cytospécifique sur l-axe hypothalamo-hypophysaire (6). Des travaux récents ont montré que le DDT et le DDE se lient chez les oiseaux et les mammifères au moyen de liaisons covalentes aux cellules de la zona fasciculata - homologue du tissu interrénal du poisson - induisant des microhémorragies. Cette « défaillance » cortisolique peut s-accompagner d-une perturbation du métabolisme glucidique et notamment d-un taux élevé de glycogène hépatique (7). Les pesticides organochlorés (

  16. Devenir des diplms Promotion 2009-2010

    E-print Network

    Sart, Remi

    de l'enquête. 66,4% occupent des fonctions cadres. Le salaire net mensuel moyen est de 1768 . Photo(s):©JérômePALL�-UniversitéBlaisePascal leur diplôme. Concernant les Masters de l'Université Blaise Pascal, les 908 diplômés de la promotion, une vue globalisée du devenir des diplômés de Master de l'Université Blaise Pascal, toutes spécialités

  17. Devenir des diplms Promotion 2010-2011

    E-print Network

    Sart, Remi

    de l'enquête. 74,6% occupent des fonctions cadres. Le salaire net mensuel moyen est de 1737 . Photo(s):©JérômePALL�-UniversitéBlaisePascal leur diplôme. Concernant les Masters de l'Université Blaise Pascal, les 1282 diplômés de la promotion, une vue globalisée du devenir des diplômés de Master de l'Université Blaise Pascal, toutes spécialités

  18. Alpha decay favoured isotopes of some superheavy nuclei: Spontaneous fission versus alpha decay

    E-print Network

    Kiren, O V; Bubbly, S G

    2013-01-01

    Spontaneous fission and alpha decay are the main decay modes for superheavy nuclei. The superheavy nuclei which have small alpha decay half-life compared to spontaneous fission half-life will survive fission and can be detected in the laboratory through alpha decay. We have studied the alpha decay half-life and spontaneous half-life of some superheavy elements in the atomic range Z = 100-130. Spontaneous fission half-lives of superheavy nuclei have been calculated using the phenomenological formula and the alpha decay half-lives using Viola-Seaborg-Sobiczewski formula (Sobiczewski et al. 1989), semi empirical relation of Brown (1992) and formula based on generalized liquid drop model proposed by Dasgupta-Schubert and Reyes (2007). The results are reported here.

  19. Alpha decay favoured isotopes of some superheavy nuclei: Spontaneous fission versus alpha decay

    E-print Network

    O. V. Kiren; S. B. Gudennavar; S. G. Bubbly

    2013-01-09

    Spontaneous fission and alpha decay are the main decay modes for superheavy nuclei. The superheavy nuclei which have small alpha decay half-life compared to spontaneous fission half-life will survive fission and can be detected in the laboratory through alpha decay. We have studied the alpha decay half-life and spontaneous half-life of some superheavy elements in the atomic range Z = 100-130. Spontaneous fission half-lives of superheavy nuclei have been calculated using the phenomenological formula and the alpha decay half-lives using Viola-Seaborg-Sobiczewski formula (Sobiczewski et al. 1989), semi empirical relation of Brown (1992) and formula based on generalized liquid drop model proposed by Dasgupta-Schubert and Reyes (2007). The results are reported here.

  20. Alpha-1 antitrypsin deficiency in emphysema.

    PubMed

    Khan, H; Salman, K A; Ahmed, S

    2002-04-01

    Human plasma contains a number of proteinase inhibitors which together form 10% of the total plasma proteins. Serine proteases are a group of closely related proteolytic enzymes, with serine in their active site. These play a key role in coagulation, fibrinolysin, kinin and complement activation. Serine protease inhibitors or "serpins" are specific inhibitors which control the activities of these enzymes. Among the serine protease inhibitors. Alpha-1 antitrypsin (alpha1 ATD) is found in highest concentration in plasma. It is the major physiologic inhibitor for neutrophil elastase. It has control over the elastase mediated degradation of elastic tissue in the lung. Alpha1ATD deficiency is a common genetic disorder and potentially lethal disease predominantly found in North European population--where the incidence is one in 2500; worldwide figures suggest that one in 6000 people have classic alpha1ATD. In cases of deficiency, antielastase activity is reduced in the lungs which results in increased elastin breakdown and development of emphysema. Cigarette smoking contributes to destructive changes in emphysema by suppressing the proteinase inhibitory activity of human serum and by inducing certain bronchoalveolar changes. Prevalence and severity of asthma increases in persons with abnormal alpha1ATD phenotype. PMID:12164415

  1. H-alpha Observations of MKW10

    NASA Astrophysics Data System (ADS)

    Johnson, Harold; Coble, Kimberly A.; Koopmann, Rebecca A.; Durbala, Adriana; Undergraduate ALFALFA Team

    2016-01-01

    As part of the Undergraduate ALFALFA Team project looking at clusters and groups of galaxies to investigate the effects of environment on star formation, we analyzed H-alpha and R-band observations of the group MKW10 from the WIYN 0.9-m telescope with MOSAIC camera at Kitt Peak. We continuum-subtract the H-alpha images by scaling and subtracting the broadband R images. This process includes: determining the seeing of each image by calculating the FWHM values of several stars in the image; convolving all images to the worst seeing; stacking images for each filter; subtracting sky background; scaling the R image to H-alpha; and subtracting the scaled R from H-alpha. We then use the H-alpha-continuum-subtracted image to perform surface photometry of individual galaxies in MKW10. The data will be used to determine star formation rates and distributions of galaxies in this group environment and will be compared to results for galaxies in other UAT group and cluster environments. Analysis is ongoing.This work has been supported by NSF grant AST-1211005 and the Illinois Space Grant Consortium.

  2. Peptide modulators of alpha-glucosidase

    PubMed Central

    Roskar, Irena; Molek, Peter; Vodnik, Miha; Stempelj, Mateja; Strukelj, Borut; Lunder, Mojca

    2015-01-01

    Aims/Introduction Acute glucose fluctuations during the postprandial period pose great risk for cardiovascular complications and thus represent an important therapeutic approach in type 2 diabetes. In the present study, screening of peptide libraries was used to select peptides with an affinity towards mammalian intestinal alpha-glucosidase as potential leads in antidiabetic agent development. Materials and Methods Three phage-displayed peptide libraries were used in independent selections with different elution strategies to isolate target-binding peptides. Selected peptides displayed on phage were tested to compete for an enzyme-binding site with known competitive inhibitors, acarbose and voglibose. The four best performing peptides were synthesized. Their binding to the mammalian alpha-glucosidase and their effect on enzyme activity were evaluated. Results Two linear and two cyclic heptapeptides with high affinity towards intestinal alpha-glucosidase were selected. Phage-displayed as well as synthetic peptides bind into or to the vicinity of the active site on the enzyme. Both cyclic peptides inhibited enzyme activity, whereas both linear peptides increased enzyme activity. Conclusions Although natural substrates of glycosidase are polysaccharides, in the present study we successfully isolated novel peptide modulators of alpha-glucosidase. Modulatory activity of selected peptides could be further optimized through peptidomimetic design. They represent promising leads for development of efficient alpha-glucosidase inhibitors. PMID:26543535

  3. Isospin symmetry in mirror {alpha} decays

    SciTech Connect

    Timofeyuk, N. K.; Johnson, R. C.; Descouvemont, P.

    2007-03-15

    We show that a consequence of isospin symmetry, recently discovered in mirror conjugated one-nucleon decays, can be extended to mirror-conjugated {alpha}-particle decays, both virtual and real. For virtual {alpha} decays of bound mirror pairs this symmetry manifests itself as a relation between the asymptotic normalization coefficients (ANCs) of {alpha}-particle overlap integrals. This relation is given by a simple analytical formula that involves {alpha}-particle separation energies and charges of residual nuclei. For bound-unbound mirror pairs, the ANC of a bound nucleus is related to the {alpha} width of the mirror unbound level. For unbound mirror pairs we get a new analytical formula that relates the widths of mirror resonances. We test the validity of these analytical formulas against the predictions of a two-body potential and of a many-body microscopic cluster model for several mirror states in {sup 7}Li-{sup 7}Be, {sup 11}B-{sup 11}C, and {sup 19}F-{sup 19}Ne isotopes. We show that these analytical formulas are valid in many cases but that some deviations can be expected for isotopes with strongly deformed and easily excited cores. In general, the results from microscopic model are not very sensitive to model assumptions and can be used to predict unknown astrophysically relevant cross sections using known information about mirror systems.

  4. Alpha-particle sensitive test SRAMs

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Blaes, B. R.

    1990-01-01

    A bench-level test is being developed to evaluate memory-cell upsets in a test SRAM designed with a cell offset voltage. This offset voltage controls the critical charge needed to upset the cell. The effect is demonstrated using a specially designed 2-micron n-well CMOS 4-kb test SRAM and a Po-208 5.1-MeV 0.61-LET alpha-particle source. This test SRAM has been made sensitive to alpha particles through the use of a cell offset voltage, and this has allowed a bench-level characterization in a laboratory setting. The experimental data are linked to a alpha-particle interaction physics and to SPICE circuit simulations through the alpha-particle collection depth. The collection depth is determined by two methods and found to be about 7 micron. In addition, alpha particles that struck outside the bloated drain were able to flip the SRAM cells. This lateral charge collection was observed to be more than 6 micron.

  5. Etudes des Reactions de Transfert LITHIUM-7/LITHIUM -6

    NASA Astrophysics Data System (ADS)

    Baddou, Djafer

    Les reactions de transfert de deux nucleons ^7Li/^6Li(^3He, rm p)^8Be/^9Be ont ete effectuees a partir d'um faisceau d'^3He initialement polarise et d'energie incidente egale a 4.58 MeV au centre de la cible. Le faisceau d'^3He est simplement ionise et il est accelere par l'accelerateur Van de Graaff de l'Universite Laval. Ce faisceau d' ^3He est de polarisation egale a 40% et il est obtenu a partir d'une source d'^3He a l'etat metastable. Nous avons decrit la reaction depuis la production et le transport du faisceau initial de l'^3 He jusqu'a la chambre de reaction. Par la suite, nous avons obtenu les distributions angulaires de la section efficace differentielle et du pouvoir d'analyse de ces reactions. Elles ont ete comparees a la theorie DWBA a l'approximation zero. La theorie a montre qu'il s'agit d'un transfert de deux particules independants (neutron, proton) pour le cas de la reaction ^7Li( ^3He,rm p)^9Be et d'un transfert de "cluster" deuteron pour le cas de la reaction ^6Li(^3He, rm p)^8Be. Notons que pour cette reaction l'instabilite du ^8Be ne nous permet pas d'avoir une diffusion elastique permettant la determination des parametres du modele optique entre ce noyau et la particule diffusee. Afin de contourner cette difficulte, nous supposons que le ^8 Be est un noyau compose de deux particules alpha et nous avons teste cette hypothese avec les reactions ^6Li(^3He, rm p)^8Be et ^7Li( ^3He,rm d)^8Be. Nous mentionnons a la fin que nous avons observe que l'etat fondamental de la reaction ^6Li( ^3He,rm p)^8Be et l'etat excite 2.43 MeV de la reaction ^7Li(^3He,rm p)^9Be sont des reactions directes alors que le premier etat excite (2.96 MeV) de la reaction ^6Li(^3He,rm p)^8Be et l'etat fondamental de la reaction ^7Li(^3He,rm p)^9Be peuvent etre domines par une reaction a noyau compose.

  6. Rpertoire des emplois au 1er dcembre 2012 Des diplms de Master 2010

    E-print Network

    Jeanjean, Louis

    selon la nomenclature de l'INSEE · Le type de contrat · Le salaire en euros · Le type d'employeur · L management administratif et financier (CTU, IAE) - Management, spécialité management des relations humaines

  7. 86419 -Stage-Caractrisation des dimensions des filaments de cellulose (FC)

    E-print Network

    Leclercq, Remi

    concevoir une méthode pour mesurer directement les dimensions des FC et d'étudier les relations entre les(s) linguistique(s) : Français parlé. Anglais parlé. Français écrit. #12;Anglais écrit. Autre(s) exigence

  8. Influence des défauts de la structure du verre sur la résistance mécanique des fibres optiques

    NASA Astrophysics Data System (ADS)

    Chmel, A.; Baptizmanski, V. V.; Kharshak, A. A.

    1992-12-01

    For silica (pure and doped) optical fibers prepared from preforms irradiated by thermal neutrons and Ar^+ ions, the measurements of lifetime under transverse stress were carried out. It is found that the neutron bombardment leads to decrease of the lifetime and the strength of fiber while the ion implantation results in increasing of these parameters. The influence of particle irradiation on the glass strength is explained by the generation of structural defects which were observed by the infrared an Raman spectroscopy methods. The direction of the change of mechanical properties of fibers is determined by the type of defects and their distribution in the cross-section of fiber. Des préformes de fibres optiques de silice ont été exposées à un bombardement par des faisceaux de neutrons thermiques et d'ions Ar^+ à énergie de 40 keV afin d'engendrer des défauts de la structure respectivement dans le volume ou dans la couche superficielle des échantillons. Les fibres obtenues des préformes irradiées et non irradiées ont été mises en charge de flexion. On a déterminé leur temps de rupture sous diverses contraintes de traction sur la surface extérieure de la fibre en flexion. On a observé une diminution du temps de rupture des fibres après le bombardement neutronique et une augmentation après l'implantation ionique. L'analyse de la nature des défauts en faisant appel à la spectroscopie infrarouge et Raman a fait ressortir que l'irradiation aux ions entraînait essentiellement des liaisons chimiques dans une fine couche superficielle de l'échantillon alors que l'irradiation aux neutrons occasionnait une déformation des zones du réseau silicique dans toute la section de la préforme et de la fibre. L'amélioration de la résistance mécanique s'explique par une augmentation de la mobilité des éléments structuraux de la matrice de verre par suite d'une rupture partielle des liaisons chimiques et sa diminution par l'apparition de concentrateurs supplémentaires de contraintes à l'échelle moléculaire.

  9. Quantification des besoins en intrants antipaludiques: contribution à l'actualisation des hypothèses pour la quantification des intrants de prise en charge des cas de paludisme grave en République Démocratique du Congo

    PubMed Central

    Likwela, Joris Losimba; Otokoye, John Otshudiema

    2015-01-01

    Les formes graves de paludisme à Plasmodium falciparum sont une cause majeure de décès des enfants de moins de 5 ans en Afrique Sub-saharienne. Un traitement rapide dépend de la disponibilité de médicaments appropriés au niveau des points de prestation de service. La fréquence des ruptures de stock des commodités antipaludiques, en particuliers celles utilisées pour le paludisme grave, avait nécessité une mise à jour des hypothèses de quantification. Les données issues de la collecte de routine du PNLP de 2007 à 2012 ont été comparées à celles rapportés par d'autres pays africains et utilisées pour orienter les discussions au cours d'un atelier organisé par le PNLP et ses partenaires techniques et financiers afin de dégager un consensus national. La proportion des cas de paludisme rapportés comme grave en RDC est resté autour d'une médiane de 7% avec un domaine de variation de 6 à 9%. Hormis la proportion rapportée au Kenya (2%), les pays africains ont rapporté une proportion de cas grave variant entre 5 et 7%. Il apparaît que la proportion de 1% précédemment utilisée pour la quantification en RDC a été sous-estimée dans le contexte de la gestion des cas graves sur terrain. Un consensus s'est dégagé autour de la proportion de 5% étant entendu que des efforts de renforcement des capacités seraient déployés afin d'améliorer le diagnostic au niveau des points de prestation des services. PMID:26213595

  10. Solution structure of {alpha}-conotoxin PIA, a novel antagonist of {alpha}6 subunit containing nicotinic acetylcholine receptors

    SciTech Connect

    Chi, Seung-Wook; Lee, Si-Hyung; Kim, Do-Hyoung; Kim, Jae-Sung; Olivera, Baldomero M.; McIntosh, J. Michael; Han, Kyou-Hoon . E-mail: khhan600@kribb.re.kr

    2005-12-30

    {alpha}-Conotoxin PIA is a novel nicotinic acetylcholine receptor (nAChR) antagonist isolated from Conus purpurascens that targets nAChR subtypes containing {alpha}6 and {alpha}3 subunits. {alpha}-conotoxin PIA displays 75-fold higher affinity for rat {alpha}6/{alpha}3{beta}2{beta}3 nAChRs than for rat {alpha}3{beta}2 nAChRs. We have determined the three-dimensional structure of {alpha}-conotoxin PIA by nuclear magnetic resonance spectroscopy. The {alpha}-conotoxin PIA has an '{omega}-shaped' overall topology as other {alpha}4/7 subfamily conotoxins. Yet, unlike other neuronally targeted {alpha}4/7-conotoxins, its N-terminal tail Arg{sup 1}-Asp{sup 2}-Pro{sup 3} protrudes out of its main molecular body because Asp{sup 2}-Pro{sup 3}-Cys{sup 4}-Cys{sup 5} forms a stable type I {beta}-turn. In addition, a kink introduced by Pro{sup 15} in the second loop of this toxin provides a distinct steric and electrostatic environment from those in {alpha}-conotoxins MII and GIC. By comparing the structure of {alpha}-conotoxin PIA with other functionally related {alpha}-conotoxins we suggest structural features in {alpha}-conotoxin PIA that may be associated with its unique receptor recognition profile.

  11. Opération multimode transverse des OPOs: des structures classiques aux corrélations quantiques

    NASA Astrophysics Data System (ADS)

    Martinelli, M.; Ducci, S.; Gigan, S.; Treps, N.; Maître, A.; Fabre, C.

    2002-06-01

    Nous démontrons la formation de structures transverses sur les faisceaux émis par un oscillateur paramétrique optique (OPO) de type II en configuration confocale. D'un point de vue classique nous mettons en évidence le caractère multimode transverse de telles structures. A travers l'étude des corrélations spatiales des faisceaux générés nous montrons que ces structures sont également multimodes d'un point de vue quantique.

  12. Interaction des ions phosphate in vitro avec des particules inhalables d'oxyde de cerium

    NASA Astrophysics Data System (ADS)

    Matton, S.; Massiot, P.; Fritsch, P.

    1998-04-01

    Methods have been developed to quantify phosphorus in vitro adsorption on inhalable CeO2 particles. Two assays are potentially useful: adsorption measurement of 32P and X-ray spectrometry. Des méthodes in vitro pour quantifier l'adsorption du phosphore sur des particules inhalables de CeO2 ont été développées. Deux tests s'avèrent utilisables : la mesure de l'adsorption du 32P et la spectrométrie X.

  13. Etat des lieux des mycobactérioses atypiques au Burkina Faso: résultats d'une enquête régionale

    PubMed Central

    Zida, Sylvie; Tarnagda, Zékiba; Kaboré, Antoinette; Zingué, Dézémon; Hien, Hervé; Sanou, Adama; Michel Gomgnimbou, Kireopori; Nouctara, Moumini; Ouédraogo, Mamoudou; Ouédraogo, Oumarou; Godreuil, Sylvain; Méda, Nicolas

    2014-01-01

    Introduction L’étude avait pour but de déterminer la fréquence d'isolement des mycobactéries atypiques chez les patients déclarés tuberculeux pulmonaire à microscopie positive (TPM+) au Burkina Faso. Méthodes Il s'est agit d'une étude transversale qui s'est déroulée de mars 2011 à février 2012. Les patients TPM+ de plus de 15 ans ont été inclus dans l’étude de manière systématique dans les centres de diagnostic et de traitement (CDT) de la région sanitaire des Hauts Bassins. Une culture des mycobactéries et une identification biochimique ont été réalisées sur les échantillons des patients TPM+ La sérologie VIH a été réalisée par des tests rapides. Résultats Une fréquence de 11% (8/73) de mycobactéries atypiques et 89,0% (65/73) de mycobactéries du complexe tuberculosis ont été identifiées des 73 patients TPM+ inclus dans l’étude. La tranche d’âge de 20 à 40 ans était la plus touchée par les mycobactérioses en général et constituait 48% de l’échantillon. Nous avons trouvé 12,2% (8 / 66) de patients VIH positif, 83,3% (55 / 66) de patients VIH négatif et 4,5% (3 / 66) de patients dont le statut VIH était indéterminé. Conclusion Notre étude a mis en lumière l'implication des mycobactéries atypiques dans la pathogénie de certains patients déclarés TPM+. Le rôle des mycobactéries atypiques dans les infections pulmonaires est probablement sous estimé et devra être examiné avec plus de détails et sur un échantillon plus grand. PMID:25396014

  14. Traitement des fractures des plateaux externes par vissage percutané assisté par arthroscopie

    PubMed Central

    Abouchane, Merouane; Belmoubarik, Amine; Benameur, Hamza; Haddoun, Ahmed Reda; Nechad, Mohammed

    2015-01-01

    Le but de notre étude est d'évaluer les résultats de fractures des plateaux tibiaux externes traitées par ostéosynthèse percutanée assistée par arthroscopie. Dix patients (8 hommes et 2 femmes) de 32 ans en moyenne ont subi cette intervention afin de réparer des fractures des plateaux tibiaux Schatzker I-III. Après avoir appliqué un garrot pneumatique, nous avons réduit et fixé la fracture au moyen de vis cannelées souschondrales. Lésions associées retrouvent deux lésions partielles du ménisque externe ont été retrouvé, traitées par résection partielle. Une orthèse de genou été de mise à but antalgique et protectrice pendant six semaines avec béquillage et interdiction de l'appui pour une durée de douze semaines avec reprise d'appui partiel au delà. La durée d'hospitalisation été d'une moyenne de cinq jours. La rééducation passive a été commence le lendemain de l'intervention et continuait dans chez un kinésithérapeute à la sortie du patient du service. Le suivi été à J7, J15, 1mois, 3mois, 6 mois puis tous les 6 mois. Neuf de nos patients ont été revu régulièrement sauf un perdu de vue. Le recul moyen de notre série été de 16 mois (10 et 24 mois). Le score de Lysholm a été utilisé pour évaluer les résultats cliniques chez nos neuf patients: excellent chez trois patients bons chez trois moyen chez un seul et mauvais chez deux patients. Tous nos neuf patients ont consolidé (figure 10 contrôle scopique d un article). Aucune gonarthrose n'a été note chez nos neuf patients due essentiellement au recul moyen faible de 16 mois. Le traitement des fractures des plateaux tibiaux externes assisté par arthroscopie produit des résultats satisfaisants et peut être accepté comme solution de rechange efficace au traitement des fractures des plateaux tibiaux causées par un choc de faible énergie. PMID:26587137

  15. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, D.W.; McAtee, J.L.

    1993-02-16

    An alpha particle detector, utilizing alternating currents, which is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  16. Alternating current long range alpha particle detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); McAtee, James L. (Los Alamos, NM)

    1993-01-01

    An alpha particle detector, utilizing alternating currents, whcih is capable of detecting alpha particles from distinct sources. The use of alternating currents allows use of simpler ac circuits which, in turn, are not susceptible to dc error components. It also allows the benefit of gas gain, if desired. In the invention, a voltage source creates an electric field between two conductive grids, and between the grids and a conductive enclosure. Air containing air ions created by collision with alpha particles is drawn into the enclosure and detected. In some embodiments, the air flow into the enclosure is interrupted, creating an alternating flow of ions. In another embodiment, a modulated voltage is applied to the grid, also modulating the detection of ions.

  17. Relativistic effects in Lyman-alpha forest

    E-print Network

    Irši?, Vid; Viel, Matteo

    2015-01-01

    We present the calculation of the Lyman-alpha (Lyman-$\\alpha$) transmitted flux fluctuations with full relativistic corrections to the first order. Even though several studies exist on relativistic effects in galaxy clustering, this is the first study to extend the formalism to a different tracer of underlying matter at unique redshift range ($z = 2 - 5$). Furthermore, we show a comprehensive application of our calculations to the Quasar- Lyman-$\\alpha$ cross-correlation function. Our results indicate that the signal of relativistic effects can be as large as 30% at Baryonic Acoustic Oscillation (BAO) scale, which is much larger than anticipated and mainly due to the large differences in density bias factors of our tracers. We construct an observable, the anti-symmetric part of the cross- correlation function, that is dominated by the relativistic signal and offers a new way to measure the relativistic terms at relatively small scales. The analysis shows that relativistic effects are important when considerin...

  18. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-08-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  19. The status of alpha-particle diagnostics

    SciTech Connect

    Young, K.M.; Johnson, D.W.

    1992-01-01

    There is a flurry of activity to complete alpha-particle diagnostics so that they can undergo some experimental testing in DT plasmas on JET or TFTR prior to implementation on ITER. Successful measurements of escaping charged fusion products have been made in DD plasmas, and the {alpha}-particle source can be well characterized by neutron profile measurement. These methods can be extrapolated to DT plasmas. Measurement of the confined {alpha}-particles requires a new technique. Collective Thomson scattering, methods involving charge-exchange interactions and nuclear reactions with impurities will be discussed. Some assessment is given of the capabilities of these techniques, bearing in mind the potential for their use in the physics phase of the ITER program.

  20. Microdosimetry for Targeted Alpha Therapy of Cancer

    PubMed Central

    Huang, Chen-Yu; Guatelli, Susanna; Oborn, Bradley M.; Allen, Barry J.

    2012-01-01

    Targeted alpha therapy (TAT) has the advantage of delivering therapeutic doses to individual cancer cells while reducing the dose to normal tissues. TAT applications relate to hematologic malignancies and now extend to solid tumors. Results from several clinical trials have shown efficacy with limited toxicity. However, the dosimetry for the labeled alpha particle is challenging because of the heterogeneous antigen expression among cancer cells and the nature of short-range, high-LET alpha radiation. This paper demonstrates that it is inappropriate to investigate the therapeutic efficacy of TAT by macrodosimetry. The objective of this work is to review the microdosimetry of TAT as a function of the cell geometry, source-target configuration, cell sensitivity, and biological factors. A detailed knowledge of each of these parameters is required for accurate microdosimetric calculations. PMID:22988479

  1. Nuclear diagnostic for fast alpha particles

    DOEpatents

    Grisham, Larry R. (Lawrence Township, Mercer County, NJ); Post, Jr., Douglass E. (Belle Mead, NJ); Dawson, John M. (Pacific Palisades, CA)

    1986-01-01

    Measurement of the velocity distribution of confined energetic alpha particles resulting from deuterium-tritium fusion reactions in a magnetically contained plasma is provided. The fusion plasma is seeded with energetic boron neutrals for producing, by means of the reaction .sup.10 B (.alpha.,n) .sup.13 N reaction, radioactive nitrogen nuclei which are then collected by a probe. The radioactivity of the probe is then measured by conventional techniques in determining the energy distribution of the alpha particles in the plasma. In a preferred embodiment, diborane gas (B.sub.2 H.sub.6) is the source of the boron neutrals to produce .sup.13 N which decays almost exclusively by positron emission with a convenient half-life of 10 minutes.

  2. Alpha-decay of light protactinium isotopes

    SciTech Connect

    Faestermann, T.; Gillitzer, A.; Hartel, K.; Henning, W.; Kienle, P.

    1987-12-10

    Light protactinium isotopes have been produced with /sup 204/Pb (/sup 19/F,xn) reactions. ..cap alpha..-activities with E/sub ..cap alpha../ = 9.90(5) MeV, T/sub 1/2/ = 53(10) ns and E/sub ..cap alpha../ = 9.65(5) MeV, T/sub 1/2/ = 0.78(16) ..mu..s could be attributed to the previously unobserved nuclei /sup 219/Pa and /sup 220/Pa with the help of excitation functions. The peak cross sections for the 4n and 3n evaporation channels are on the order of 10 ..mu..b. The decay energies as well as the halflives fit well into the systematics of these nuclei close to the magic neutron number N = 126. /sup 219/Pa is the shortest lived nuclide known with directly measured halflife.

  3. Synthesis of peptide .alpha.-thioesters

    DOEpatents

    Camarero, Julio A. (Livermore, CA); Mitchell, Alexander R. (Livermore, CA); De Yoreo, James J. (Clayton, CA)

    2008-08-19

    Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide .alpha. thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. When the peptide synthesis has been completed, activation of the linker is achieved by mild oxidation. The oxidation step converts the acyl-hydrazine group into a highly reactive acyl-diazene intermediate which reacts with an .alpha.-amino acid alkylthioester (H-AA-SR) to yield the corresponding peptide .alpha.-thioester in good yield. A variety of peptide thioesters, cyclic peptides and a fully functional Src homology 3 (SH3) protein domain have been successfully prepared.

  4. Lyman-alpha imagery of Comet Kohoutek

    NASA Technical Reports Server (NTRS)

    Carruthers, G. R.; Opal, C. B.; Page, T. L.; Meier, R. R.; Prinz, D. K.

    1974-01-01

    Electrographic imagery of Comet Kohoutek in the 1100-1500 A wavelength range was obtained from a sounding rocket on Jan. 8, 1974, and from the Skylab space station on 13 occasions between Nov. 26, 1973 and Feb. 2, 1974. These images are predominantly due to Lyman-alpha (1216 A) emission from the hydrogen coma of the comet. The rocket pictures have been calibrated for absolute sensitivity and a hydrogen production rate has been determined. However, the Skylab camera suffered degradation of its sensitivity during the mission, and its absolute sensitivity for each observation can only be estimated by comparison of the comet images with those taken by the rocket camera, with imagery of the geocoronal Lyman-alpha glow, of the moon in reflected Lyman-alpha, and of ultraviolet-bright stars. The rocket and geocoronal comparisons are used to derive a preliminary, qualitative history of the development of the cometary hydrogen coma and the associated hydrogen production rate.

  5. Dépistage des maladies cardiovasculaires chez des étudiants de l'Université de Douala et influence des activités physiques et sportives

    PubMed Central

    Ewane, Marielle Epacka; Mandengue, Samuel Honoré; Priso, Eugene Belle; Tamba, Stéphane Moumbe; Ahmadou; Fouda, André Bita

    2012-01-01

    Introduction Les maladies cardiovasculaires (MCV) constituent l'une des principales causes de mortalité dans les pays en développement. Le dépistage de ces dernières chez des jeunes est un défi dans la lutte contre leur expansion. Le but de cette étude était de dépister ces maladies au sein d'une population jeunes d’étudiants camerounais. Methodes Deux mille six cent cinquante-huit étudiants de l'Université de Douala (23,6 ± 2,9 ans, sex-ratio H/F = 0,9) ont en Avril - Mai 2011 participé à une campagne de dépistage gratuit du diabète, de l'hypertension artérielle (HTA) et de l'obésité. Ils ont également été soumis à une d'enquête évaluant leur niveau en activités physiques et sportives (APS). Resultats 12,7% des participants avaient une pression artérielle (PA) ? 140/90 mmHg, 3,6% étaient obèses et 0,9% avaient une glycémie ?1,26 g/L. Des corrélations ont été trouvées entre certains facteurs de risque (diabète, hypertension et obésité) et le niveau académique d'une part (r =0,366; p < 0,0001) et le temps passé devant la télévision d'autres part (r = 0,411; p < 0,0001). L‘APS était inversement corrélée à l‘âge (r =-0,015; p < 0,0001) et au temps passé devant la télévision (r = -0,059; p = 0,002). Conclusion La présence des MCV et leurs facteurs de risque mis en évidence dans cette étude réalisée en milieu estudiantin camerounais interpelle à une prévention et une éducation dans la lutte contre ces dernières. PMID:22655111

  6. alpha 2-Antiplasmin Enschede: dysfunctional alpha 2-antiplasmin molecule associated with an autosomal recessive hemorrhagic disorder.

    PubMed Central

    Kluft, C; Nieuwenhuis, H K; Rijken, D C; Groeneveld, E; Wijngaards, G; van Berkel, W; Dooijewaard, G; Sixma, J J

    1987-01-01

    alpha 2-Antiplasmin (alpha 2-AP) is a major fibrinolysis inhibitor, whose complete, congenital absence has been found to be associated with a distinct hemorrhagic diathesis. We studied a 15-yr-old male with a hemorrhagic diathesis after trauma from early childhood on. This bleeding tendency was associated with a minimal alpha 2-AP level recorded functionally in the immediate plasmin inhibition test: less than or equal to 4% of normal. However, a normal plasma concentration of alpha 2-AP antigen (83%) was found. His sister (5 yr old) showed similar results (2 and 92%). In their family, eight heterozygotes could be identified by half-normal activity results and normal antigen concentrations. The inheritance pattern is autosomal recessive. On analysis, the alpha 2-AP of the propositus was homogeneous in all respects tested, suggesting a homozygous defect. We designated the abnormal alpha 2-AP as alpha 2-AP Enschede. alpha 2-AP Enschede showed the following characteristics: (a) complete immunological identity with normal alpha 2-AP; (b) normal molecular weight (sodium dodecyl sulfate-polyacrylamide gel electrophoresis); (c) normal alpha-electrophoretic mobility; (d) presence in plasma of both molecular forms excluding an excessive conversion to the less reactive non-plasminogen-binding form; (e) quantitatively normal binding to lys-plasminogen and to immobilized plasminogen kringle 1-3; and (f) normal Factor XIII-mediated binding to fibrin. Functional abnormalities were found in: (i) no inhibition of amidolytic activities of plasmin and trypsin, even on prolonged incubation; (ii) no formation of plasmin-antiplasmin complexes in plasma with plasmin added in excess; and (iii) no inhibition of fibrinolysis by fibrin-bound alpha 2-AP. In the heterozygotes, the presence of abnormal alpha 2-AP did not interfere with several functions of the residual normal alpha 2-AP. One-dimensional peptide mapping showed an abnormal pattern of papain digestion. We conclude that in this family, abnormal antiplasmin molecules, defective in plasmin inhibition but with normal plasminogen-binding properties, have been inherited. The residual plasminogen-binding properties do not protect against a hemorrhagic diathesis. Images PMID:2445779

  7. Contrôle du marché informel à l’heure de la mondialisation des échanges. Le cas des antirétroviraux au Chili

    PubMed Central

    Brousselle, Astrid; Morales, Cristián

    2013-01-01

    Résumé Les nouveaux médicaments pour le VIH/sida ont créé des besoins d’accessibilité aux traitements que les gouvernements n’ont pas toujours réussi à couvrir. Il en résulte l’émergence d’un marché informel des ARV. Par l’analyse de la situation au Chili, nous traitons des différents créneaux d’approvisionnement, des conséquences de l’existence d’un tel marché, ainsi que des moyens envisageables pour réduire les effets indésirables. Les aspects tant microéconomiques que macroéconomiques concernant le marché et l’accessibilité aux médicaments sont abordés. PMID:23997580

  8. Recent advances of the electrostatic long-range alpha detector

    SciTech Connect

    Johnson, J.D.; Allander, K.S.; Bounds, J.A.; Garner, S.E.; Johnson, J.P.; MacArthur, D.W.; Sprouse, L.

    1994-07-01

    Long-range alpha detector (LRAD) systems are designed to monitor alpha sources and contamination by measuring the number of ions created in air by ionizing radiation. Traditional alpha detectors are designed to detect alpha particles directly and must be passed slowly within 3 cm of an alpha source to operate effectively. LRAD detectors collect the ions created from alpha interaction with air. Therefore, they are better able to monitor equipment and complex surfaces and can be operated at a much greater distance from an alpha source than traditional alpha detectors. Furthermore, because LRAD detectors remain stationary during monitoring, they are less subject to operator error than traditional alpha detectors. This paper will discuss the basic operation as well as recent advances that have been made to the electrostatic LRAD.

  9. Comprendre la maltraitance des aînés en pratique familiale

    PubMed Central

    Yaffe, Mark J.; Tazkarji, Bachir

    2012-01-01

    Résumé Objectif Présenter ce qui constitue la maltraitance des aînés, ce dont les médecins de famille devraient être au courant, les signes et les symptômes laissant présager de mauvais traitements chez des adultes plus âgés, comment l’outil Elder Abuse Suspicion Index peut aider à détecter la maltraitance et les options qui existent pour réagir en cas de soupçons de maltraitance. Sources des données On a fait une recension dans MEDLINE, PsycINFO et Social Work Abstracts pour trouver des publications en français ou en anglais, de 1970 à 2011, à l’aide des expressions elder abuse, elder neglect, elder mistreatment, seniors, older adults, violence, identification, detection tools et signs and symptoms. Les publications pertinentes ont fait l’objet d’un examen. Message principal La maltraitance des aînés est une cause importante de morbidité et de mortalité chez les adultes plus âgés. Si les médecins de famille sont bien placés pour détecter des mauvais traitements infligés aux aînés, leurs taux réels de signalement de cas de maltraitance sont plus faibles que dans d’autres professions. Cette situation pourrait s’améliorer s’ils comprenaient mieux les genres d’agissements qui constituent de la maltraitance des aînés, ainsi que les signes et les symptômes observés au bureau qui pourraient pointer vers des cas de mauvais traitements. La détection de tels cas pourrait être facilitée par le recours à un court outil validé, comme l’Elder Abuse Suspicion Index. Conclusion Les médecins de famille peuvent jouer un rôle plus important dans la détection d’une éventuelle maltraitance des aînés. Une fois qu’on soupçonne de mauvais traitements, il existe dans la plupart des communautés des services sociaux ou des forces de l’ordre accessibles pour effectuer des évaluations plus approfondies et intervenir.

  10. Hydrogen Lyman-alpha coronagraph/polarimeter

    NASA Technical Reports Server (NTRS)

    Fineschi, Silvano; Hoover, Richard B.; Walker, Arthur B. C., Jr.

    1992-01-01

    The present treatment of vector magnetic field measurement in coronas by means of the Hanle effect of the Lyman-alpha line uses data from all-reflecting imaging coronagraph/polarimeters. The polarization sensitivity, bandpass, and spatial resolution of these instruments are defined through a modeling of the Hanle-effect signature in Lyman-alpha emission from coronal magnetic loops; the line-of-sight integration through an inhomogeneous coronal medium is taken into account. The use of the Hanle effect to measure solar corona vector magnetic fields is verified.

  11. Workshop on Precision Measurements of alphas

    E-print Network

    S. Bethke; A. H. Hoang; S. Kluth; J. Schieck; I. W. Stewart; S. Aoki; M. Beneke; J. Blumlein; N. Brambilla; S. Brodsky; S. Descotes-Genon; J. Erler; S. Forte; T. Gehrmann; C. Glasman; M. Golterman; S. Hashimoto; A. Kronfeld; J. Kuhn; P. Lepage; A. Martin; V. Mateu; S. Menke; Y. Nomura; C. Pahl; F. Petriello; A. Pich; K. Rabbertz; G. Salam; H. Schulz; R. Sommer; M. Steinhauser; B. Webber; CP. Yuan; G. Zanderighi

    2011-10-22

    These are the proceedings of the "Workshop on Precision Measurements of alphas" held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of alphas(mZ) in the MS-bar scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, tau-decays, electroweak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.

  12. {alpha} Decay of Deformed Actinide Nuclei

    SciTech Connect

    Stewart, T.L.; Kermode, M.W.; Beachey, D.J.; Rowley, N.; Grant, I.S.; Kruppa, A.T.

    1996-07-01

    {alpha} decay through a deformed potential barrier produces significant mixing of angular momenta when mapped from the nuclear interior to the outside. Using experimental branching ratios and either semiclassical or coupled-channels transmission matrices, we have found that there is a set of internal amplitudes which is essentially constant for all even-even actinide nuclei. These same amplitudes also give good results for the known anisotropic {alpha}-particle emission of the favored decays of odd nuclei in the same mass region. {copyright} {ital 1996 The American Physical Society.}

  13. Monitoring airborne alpha-emitter contamination

    SciTech Connect

    Kerr, P.L.; Koster, J.E.; Conaway, J.G.; Bounds, J.A.; Whitley, C.W.; Steadman, P.A.

    1998-02-01

    Facilities that may produce airborne alpha emitter contamination require a continuous air monitoring (CAM) system. However, these traditional CAMs have difficulty in environments with large quantities of non-radioactive particulates such as dust and salt. Los Alamos has developed an airborne plutonium sensor (APS) for the REBOUND experiment at the Nevada Test Site which detects alpha contamination directly in the air, and so is less vulnerable to the problems associated with counting activity on a filter. In addition, radon compensation is built into the detector by the use of two measurement chambers.

  14. Intense Ly-alpha emission from Uranus

    NASA Technical Reports Server (NTRS)

    Durrance, S. T.; Moos, H. W.

    1982-01-01

    The existence of intense atomic hydrogen Ly-alpha emission from Uranus is demonstrated here by utilizing the monochromatic imaging capabilities of the International Ultraviolet Explorer (IUE) spectrograph. Observations show increased emission in the vicinity of Uranus superimposed on the geocoronal/interplanetary background. If resonant scattering of solar Ly-alpha is the source of the 1.6 + or - 0.4 kR disk averaged brightness, then very high column densities of atomic H above the absorbing methane are required. Precipitation of trapped charged particles, i.e., aurora, could explain the emissions. This would imply a planetary magnetic field.

  15. Lunar surface outgassing and alpha particle measurements

    SciTech Connect

    Lawson, S. L.; Feldman, W. C.; Lawrence, David J. ,; Moore, K. R.; Elphic, R. C.; Maurice, S.; Belian, Richard D.; Binder, Alan B.

    2002-01-01

    The Lunar Prospector Alpha Particle Spectrometer (LP APS) searched for lunar surface gas release events and mapped their distribution by detecting alpha particle?; produced by the decay of gaseous radon-222 (5.5 MeV, 3.8 day half-life), solid polonium-2 18 (6.0 MeV, 3 minute half-life), and solid polonium-210 (5.3 MeV, 138 day half-life, but held up in production by the 21 year half-life of lead-210). These three nuclides are radioactive daughters from the decay of uranium-238.

  16. Fan-less long range alpha detector

    DOEpatents

    MacArthur, Duncan W. (Los Alamos, NM); Bounds, John A. (Los Alamos, NM)

    1994-01-01

    A fan-less long range alpha detector which operates by using an electrical field between a signal plane and the surface or substance to be monitored for air ions created by collisions with alpha radiation. Without a fan, the detector can operate without the possibility of spreading dust and potential contamination into the atmosphere. A guard plane between the signal plane and the electrically conductive enclosure and maintained at the same voltage as the signal plane, reduces leakage currents. The detector can easily monitor soil, or other solid or liquid surfaces.

  17. Fan-less long range alpha detector

    DOEpatents

    MacArthur, D.W.; Bounds, J.A.

    1994-05-10

    A fan-less long range alpha detector is disclosed which operates by using an electrical field between a signal plane and the surface or substance to be monitored for air ions created by collisions with alpha radiation. Without a fan, the detector can operate without the possibility of spreading dust and potential contamination into the atmosphere. A guard plane between the signal plane and the electrically conductive enclosure and maintained at the same voltage as the signal plane, reduces leakage currents. The detector can easily monitor soil, or other solid or liquid surfaces. 2 figures.

  18. Evaluation of plasma alpha-2-macroglobulin and interactions with tumour necrosis factor-alpha in horses with endotoxemic signs.

    PubMed Central

    Coté, N; Trout, D R; Hayes, A M

    1996-01-01

    The electrophoretic position and behavior of the native and activated forms of equine plasma alpha-2-macroglobulin (alpha 2M) were characterized and compared to human alpha 2M by nondenaturing polyacrylamide-gel electrophoresis (PAGE). Plasma alpha 2M was also compared between 6 normal horses and 6 horses with clinical signs of colic and endotoxemia due to volvulus or enteritis. Native and activated forms of alpha 2M were quantified by PAGE and densitometry. Binding of radio-labeled recombinant human tumour necrosis factor-alpha (125I-rhTNF-alpha) to native and activated forms of equine alpha 2M was also evaluated by autoradiography and densitometry of PAGE. Equine plasma alpha 2M migrated as a single band at a position equivalent to native human alpha 2M. Methylamine-reacted equine plasma samples resulted in faster migration of alpha 2M in a similar position to activated human alpha 2M. However, in methylamine-reacted equine plasma, an intermediate alpha 2M band was consistently present between the bands corresponding to native and activated alpha 2M. Amounts of plasma alpha 2M were similar in normal and endotoxemic horses, and remained in the electrophoretically slow or unreacted native form. The vast majority of 125I-rHuTNF-alpha did not bind to alpha 2M or other equine plasma proteins. 125I-rHuTNF-alpha bound weakly to both native and fast methylamine-reacted equine forms of alpha 2M, although binding was better to the activated form. This study indicates that: (1) equine plasma alpha 2M behaves similarly to human alpha 2M on PAGE, (2) plasma alpha 2M of horses can be activated to electrophoretically fast forms, but it is neither activated nor depleted during endotoxemia, and (3) the binding interactions between equine alpha 2M and TNF-alpha are too low to implicate equine alpha 2M as a regulator of TNF-alpha during endotoxemia in horses. Images Figure 1. Figure 2. Figure 3. PMID:8785722

  19. Green Pea Galaxies Reveal Secrets of Ly$\\alpha$ Escape

    E-print Network

    Yang, Huan; Gronke, Max; Rhoads, James E; Jaskot, Anne; Zheng, Zhenya; Dijkstra, Mark

    2015-01-01

    Star-formation in galaxies generates a lot of Ly$\\alpha$ photons. Understanding the escape of Ly$\\alpha$ photons from galaxies is a key issue in studying high redshift galaxies and probing cosmic reionization with Ly$\\alpha$. To understand Ly$\\alpha$ escape, it is valuable to study analogs of high redshift Ly$\\alpha$ emitters in nearby universe. However, most nearby analogs have too small a Ly$\\alpha$ equivalent width and escape fraction compared to high redshift Ly$\\alpha$ emitters. One different group of nearby analogs are "Green Pea" galaxies, selected by their high equivalent width optical emission lines. Here we show that Green Pea galaxies have strong Ly$\\alpha$ emission lines and high Ly$\\alpha$ escape fraction (see also Henry et al. 2015), providing an opportunity to solve Ly$\\alpha$ escape problem. Green Peas have a Ly$\\alpha$ equivalent width distribution similar to high redshift Ly$\\alpha$ emitters. The Ly$\\alpha$ escape fraction correlates with many quantities of Ly$\\alpha$ profile, especially the...

  20. Effets des electrons secondaires sur l'ADN

    NASA Astrophysics Data System (ADS)

    Boudaiffa, Badia

    Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire dans un etat electronique dissociatif, cette localisation est suivie d'une fragmentation. A plus haute energie, la dissociation dipolaire (i.e., la formation simultanee d'un ion positif et negatif) et l'ionisation jouent un role important dans le dommage de l'ADN. L'ensemble de nos resultats permet d'expliquer les mecanismes de degradation de l'ADN par les EBE et d'obtenir des sections efficaces effectives des differents types de dommages.

  1. Reprsentation des connaissances Traitement du langage naturel

    E-print Network

    Turenne, Nicolas

    items lexicaux ambigus. Si vous ne percevez pas l'ambiguïté, pensez à ('time flies' analogue à 'fruit de ce phénomène, tels que 'Times flies like an arrow', où 'time', 'flies' et 'like' sont tous des flies'. Une forme probablement plus ennuyeuse d'ambiguïté est connue sous le nom d' ambiguïté d

  2. L'exploitation des populations naturelles

    E-print Network

    Blouin-Demers, Gabriel

    ;Tragedy of the commons Les décisions sont prises par des individus... #12;· La simplicité de l est K/2 K K/2 rK/4 #12;Journal of the Fisheries Research Board of Canada (1967) 24: 145-190 #12;Modèle jeunes poissons en fonction d'un index de population de morue Journal of the Fisheries Research Board

  3. La dysplasie fibreuse: état des lieux

    PubMed Central

    Akasbi, Nessrine; Abourazzak, Fatima Ezzahra; Talbi, Sofia; Tahiri, Latifa; Harzy, Taoufik

    2015-01-01

    La dysplasie fibreuse des os est une affection osseuse bénigne congénitale mais non héréditaire, où l'os normal est remplacé par un tissu fibreux renfermant une ostéogenèse immature. Elle est due à une mutation du gène GNAS 1sur le chromosome 20q13, une mutation activatrice de la sous-unité ? de la protéine G. C'est une pathologie qui est le plus souvent silencieuse, de découverte fortuite sur une radiographie standard ou révélée par une douleur osseuse ou une fracture pathologique. L'imagerie et l'histologie, quand elle est nécessaire, permettent d’établir le diagnostic. Bien qu'il ne s'agisse pas d'une tumeur, elle est souvent classée dans la catégorie des tumeurs osseuses bénignes pour des raisons de diagnostic différentiel radiographique et anatomopathologique. Elle peut être monostotique ou polyostotique. L'approche thérapeutique est essentiellement symptomatique. Quelques publications récentes ont suggéré l'intérêt majeur d'un bisphosphonate, en particulier le pamidronate, qui diminuerait les douleurs et stimulerait une reminéralisation progressive des zones ostéolytiques chez les patients traités. D'autres traitements tels que la thérapie ciblée sont en cours d’évaluation. PMID:26401215

  4. Mechanik des Grun Fluoreszierenden Hendrik Dietz

    E-print Network

    Dietz, Hendrik

    .3 Wildtype-GFP und Cycle3-GFP . . . . . . . . . . . . . . . . . . . . . . . . 5 2.4 Fluoreszenz als Indikator des nativen GFP . . . . . . . . . . . . . . . . . . 6 3 Theoretische Grundlagen 9 3.1 Elastizit¨at von-Carlo Simulationen . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 5 Ig8-GFP und DdFLN(1-5)-GFP 27 5

  5. The "Conservatoire National des Arts et Metiers"

    ERIC Educational Resources Information Center

    Kuhn, Gerard

    2004-01-01

    The overall mission of the Conservatoire national des arts et metiers--(CNAM) [National Conservatory of Industrial Arts and Trades] is outlined. One of its centers, the "Centre national de l'entrepreneuriat"--(CNE) [National Center for Entrepreneurship] is described in greater detail. In particular, this center offers various services, notably…

  6. Etats financiers 2008 Table des matires

    E-print Network

    Halazonetis, Thanos

    supplémentaires du personnel administratif et technique 13 2.19. Fonds alloués par des tiers 13 2.20. Contrats de.2. Détention d'actif dans la société CIBM 23 20.3. Contrats de location 23 20.4. Contrats de leasing 23 21

  7. Bibliothque cole des Ponts ParisTech

    E-print Network

    Ghorbel, Amin

    mécanique et matériaux [ La Bibliothèque propose aux étudiants des espaces pour travailler seul ou en groupe://bibliotheque.enpc.fr Les espaces de travail Une équipe de documentalistes Les ressources pédagogiques #12;. Trois salles de travail en groupe peuvent être réservées à l'accueil de la bibliothèque. Chacune est

  8. Bibliothque cole des Ponts ParisTech

    E-print Network

    Ghorbel, Amin

    mécanique et matériaux [ La Bibliothèque propose aux étudiants des espaces pour travailler seul ou en groupe://bibliotheque.enpc.fr Les espaces de travail Une équipe de documentalistes Les ressources pédagogiques Vivien Girard Travaux. Quatre espaces projet peuvent être réservés à l'accueil de la bibliothèque. Chacun est équipé d'un écran

  9. Studienordnung des Masterstudiengangs ,,Health Care Management"

    E-print Network

    Greifswald, Ernst-Moritz-Arndt-Universität

    1 Studienordnung des Masterstudiengangs ,,Health Care Management" an der Ernst-Moritz-Arndt-Universität Greifswald die folgende Studienordnung für den Masterstudiengang ,,Health Care Management" als Satzung Master- studiengang (M.Sc.) ,,Health Care Management" an der Ernst-Moritz-Arndt-Universität Greifswald

  10. Studienordnung des Masterstudiengangs ,,Health Care Management"

    E-print Network

    Greifswald, Ernst-Moritz-Arndt-Universität

    Studienordnung des Masterstudiengangs ,,Health Care Management" an der Ernst-Moritz-Arndt-Universität Greifswald die fol- gende Studienordnung für den Masterstudiengang ,,Health Care Manage- ment" als Satzung Masterstudiengang (M.Sc.) ,,Health Care Management" an der Ernst-Moritz- Arndt-Universität Greifswald vom 15. März

  11. La conservation des phoques gris (Halichoerus grypus)

    E-print Network

    Blouin-Demers, Gabriel

    » · Pollution ­ Dégradation et perte d'habitat · Exploitation des ressources marines ­ Energie renouvelable Protection Act » de 1972 · Chasse interdite en 1987 (Pêche et Océan Canada) #12;Energie renouvelable marine (Exemple de l'Irlande) Marine Policy 35 (2011) 748­755 #12;Energie renouvelable marine #12;Pêches

  12. Modélisation macroscopique des milieux stratifiés conducteurs

    NASA Astrophysics Data System (ADS)

    Matagne, E.; Conard, J. Ph.

    1997-11-01

    Many laminated structures are recognised in Electrotechnics : magnetic cores, flat conductors windings, slotted surfaces... These structures exhibit macroscopic properties, as magnetic than electric ones. This paper shows how these characteristics can be obtained by homogenisation. It deals with linear materials but taking into account the effect of eddy currents, as well on the macroscopic magnetic permeability as on the macroscopic electric conductivity, which become then complex numbers. An example of use of the macroscopic properties is provided. On peut identifier en électrotechnique de nombreuses structures stratifiées: noyaux magnétiques, bobinages formés de conducteurs plats, surfaces encochées... Ces structures présentent des propriétés macroscopiques tant magnétiques qu'électriques. Cet article montre comment ces caractéristiques peuvent être obtenues par homogénéisation. Il se limite au cas de matériaux linéaires mais en prenant en compte l'effet des courants de Foucault aussi bien sur la perméabilité magnétique macroscopique que sur la conductivité électrique macroscopique, grandeurs qui deviennent alors des nombres complexes. Un exemple d'utilisation des caractéristiques macroscopiques est fourni.

  13. Le cynisme des chiens Jacky Dahomay.

    E-print Network

    Blondel, Corinne - Institut de Mathématiques de Jussieu, Université Paris 7

    'a littéralement bouleversé. Et j'ai pleuré. De rage bien entendu. Je suis un vieil enseignant, à la veille de la'indignation. Toutefois, des chiens, préservons-nous de leur rage et de leur cynisme. J'emprunte cette expression « le

  14. More About Spurious Numerical Solutions Of DEs

    NASA Technical Reports Server (NTRS)

    Yee, H. C.; Sweby, P. K.

    1995-01-01

    Paper discusses reliability of time-dependent approach to numerical solution of nonlinear differential equations (DEs) that describe steady-state behaviors of physical systems. Time-dependent approach followed in related study described in "Spurious Numerical Solutions of Differential Equations" (ARC-13209).

  15. 06seleccin de contenidos DES-IGUALES

    E-print Network

    Fernández Pascual, Ricardo

    06selección de contenidos IGUALDAD DES-IGUALES Laura Arroyo LA RESPUESTA PATRIARCAL A LA CRISIS: UN NUEVO TIMO A LAS MUJERES Laura Nuño DESIGUALDADES POR GÉNERO Y EDAD. LA DOBLE DESIGUALDAD DE LAS MUJERES. Universidad Rey Juan Carlos. Desigualdades por género y edad. La doble desigualdad de las mujeres jóvenes

  16. Etudes physiques des mélanges eau-cryoprotecteurs

    NASA Astrophysics Data System (ADS)

    Vassoille, R.; Perez, J.

    The aim of the following review is to present the most important studies concerning the physical properties of water-solutes mixtures used in cryobiology. Cryobiology is a branch of biology which deals with the very low temperature behaviour of cells. This technique is developed today in several directions. The creation of banks of cells and perhaps in a short time of small organs, is the purpose of much research in this domain. Before freezing, living cells are generally put in a solution containing one or more solutes. The role of these solutes is to protect the cells against damage due to crystallization of water (cryoprotectors). The mechanisms of cryoprotection are not well known ; nevertheless the vitreous state formation during cooling is often invoked. So, it is possible to avoid crystallization damage such as mechanical strain (due to an increase of volume of about 10 %) and salt effects (due to osmotic pressure). The conditions in which the vitreous state is obtained, maintained during cooling, storage at low temperature and rewarming can be defined by physical studies presented in the following review. Le présent travail est essentiellement une revue bibliographique des principales études physiques qui ont été réalisées avec des solutions de composés habituellement employés en cryobiologie. La cryobiologie est une branche de la biologie qui s'intéresse au comportement des cellules à basse température. Cette discipline est actuellement en plein développement dans des domaines très divers. Son principal but est la création de banques de cellules de plus en plus complexes avec comme perspective la conservation des organes. Les cellules vivantes sont généralement placées avant congélation dans une solution contenant divers composés dont le rôle est de protéger les cellules contre les effets de la cristallisation de l'eau. L'action protectrice de ces cryoprotecteurs est encore mal connue; cependant, la formation d'un état vitreux lors du refroidissement est souvent invoquée. Ainsi, il est possible d'éviter les dommages liés à la cristallisation : contrainte mécanique due à l'augmentation de volume, effets de sel dus à l'existence d'un gradient de pression osmotique de part et d'autre de la membrane cellulaire. Les conditions d'obtention et de maintien de cet état vitreux lors des opérations de congélation peuvent être définies par des études physiques dont nous proposons une revue.

  17. Alpha particle behavior, modeling and monitoring using long-range alpha detector (LRAD) technology

    SciTech Connect

    Johnson, J.D.; Allander, K.A.; Bounds, J.A.

    1993-10-01

    Long-Range Alpha Detector (LRAD) systems are used to measure alpha sources by directly measuring the ionization caused by the alpha Particle interaction with air. Two different types of alpha detectors have been developed using LRAD technology: air-flow and fanless detectors. Investigations have been carried out using these detectors to transport properties of the ion pairs created by alpha par-pressures and temperatures in several different gasses. Tests have also being carried out to determine the effects of variation in airflow on detector response. Monte Carlo codes have been written to better model the stopping distance and behavior of alpha particles, beta particles and ions for various source and detector geometries. LRAD detectors have proven to be many times more sensitive than traditional alpha detectors and, therefore, may be used in applications for which a high degree of sensitivity is required. This paper will discuss the results of our tests, as well as the basic LRAD technology and its applications.

  18. The alpha-form of the hydroxides of bivalent metals

    NASA Technical Reports Server (NTRS)

    Feitknecht, W.

    1984-01-01

    X-ray analyses were made of the hydroxides of the bivalent metals. The freshly pptd. hydroxide is usually in the alpha-form, which on standing is converted to another form or other forms. The alpha and c grating dimensions of the alpha-form and the C6-type of Co, Zn, C, Co-Zn and Ni-Zn hydroxides are tabulated. Ni hydroxide does not exhibit an alpha-form. The alpha-Co(OH)2, the blue form, is stabilized by sugar or by the higher alcohols: these compounds do not stabilize alpha-Zn(OH)2.

  19. Aspergillus nidulans alpha-galactosidase of glycoside hydrolase family 36 catalyses the formation of alpha-galacto-oligosaccharides by transglycosylation.

    PubMed

    Nakai, Hiroyuki; Baumann, Martin J; Petersen, Bent O; Westphal, Yvonne; Hachem, Maher Abou; Dilokpimol, Adiphol; Duus, Jens Ø; Schols, Henk A; Svensson, Birte

    2010-09-01

    The alpha-galactosidase from Aspergillus nidulans (AglC) belongs to a phylogenetic cluster containing eukaryotic alpha-galactosidases and alpha-galacto-oligosaccharide synthases of glycoside hydrolase family 36 (GH36). The recombinant AglC, produced in high yield (0.65 g.L(-1) culture) as His-tag fusion in Escherichia coli, catalysed efficient transglycosylation with alpha-(1-->6) regioselectivity from 40 mm 4-nitrophenol alpha-d-galactopyranoside, melibiose or raffinose, resulting in a 37-74% yield of 4-nitrophenol alpha-D-Galp-(1-->6)-D-Galp, alpha-D-Galp-(1-->6)-alpha-D-Galp-(1-->6)-D-Glcp and alpha-D-Galp-(1-->6)-alpha-D-Galp-(1-->6)-D-Glcp-(alpha1-->beta2)-d-Fruf (stachyose), respectively. Furthermore, among 10 monosaccharide acceptor candidates (400 mm) and the donor 4-nitrophenol alpha-D-galactopyranoside (40 mm), alpha-(1-->6) linked galactodisaccharides were also obtained with galactose, glucose and mannose in high yields of 39-58%. AglC did not transglycosylate monosaccharides without the 6-hydroxymethyl group, i.e. xylose, L-arabinose, L-fucose and L-rhamnose, or with axial 3-OH, i.e. gulose, allose, altrose and L-rhamnose. Structural modelling using Thermotoga maritima GH36 alpha-galactosidase as the template and superimposition of melibiose from the complex with human GH27 alpha-galactosidase supported that recognition at subsite +1 in AglC presumably requires a hydrogen bond between 3-OH and Trp358 and a hydrophobic environment around the C-6 hydroxymethyl group. In addition, successful transglycosylation of eight of 10 disaccharides (400 mm), except xylobiose and arabinobiose, indicated broad specificity for interaction with the +2 subsite. AglC thus transferred alpha-galactosyl to 6-OH of the terminal residue in the alpha-linked melibiose, maltose, trehalose, sucrose and turanose in 6-46% yield and the beta-linked lactose, lactulose and cellobiose in 28-38% yield. The product structures were identified using NMR and ESI-MS and five of the 13 identified products were novel, i.e. alpha-D-Galp-(1-->6)-D-Manp; alpha-D-Galp-(1-->6)-beta-D-Glcp-(1-->4)-D-Glcp; alpha-D-Galp-(1-->6)-beta-D-Galp-(1-->4)-D-Fruf; alpha-D-Galp-(1-->6)-D-Glcp-(alpha1-->alpha1)-D-Glcp; and alpha-D-Galp-(1-->6)-alpha-D-Glcp-(1-->3)-D-Fruf. PMID:20681989

  20. Des recommandations probantes pour surveiller l’innocuité des antipsychotiques de deuxième génération chez les enfants et les adolescents

    PubMed Central

    Pringsheim, Tamara; Panagiotopoulos, Constadina; Davidson, Jana; Ho, Josephine

    2012-01-01

    HISTORIQUE : Au Canada, l’utilisation d’antipsychotiques, notamment les antipsychotiques de deuxième génération (ADG), a augmenté de façon considérable depuis cinq ans chez les enfants ayant des troubles de santé mentale. Ces médicaments ont le potentiel de causer de graves complications métaboliques et neurologiques lorsqu’on les utilise de manière chronique. OBJECTIF : Synthétiser les données probantes relatives aux effets secondaires métaboliques et neurologiques précis associés à l’usage d’ADG chez les enfants et fournir des recommandations probantes sur la surveillance de ces effets secondaires. MÉTHODOLOGIE : Les auteurs ont procédé à une analyse systématique des essais cliniques contrôlés des ADG auprès d’enfants. Ils ont fait des recommandations à l’égard de la surveillance de l’innocuité des ADG d’après un modèle de classification fondé sur le système GRADE (système de notation de l’évaluation et de l’élaboration des recommandations). Lorsque les données probantes n’étaient pas suffisantes, ils fondaient leurs recommandations sur le consensus et l’avis d’experts. Un groupe consensuel multidisciplinaire a analysé toutes les données probantes pertinentes et est parvenu à un consensus à l’égard des recommandations. RÉSULTATS : Les recommandations probantes portant sur la surveillance de l’innocuité des ADG figurent dans les présentes lignes directrices. Les auteurs indiquent la qualité des recommandations relatives à des examens physiques et tests de laboratoire précis à l’égard de chaque ADG à des moments déterminés. CONCLUSION : De multiples essais aléatoires et contrôlés ont permis d’évaluer l’efficacité de bon nombre des ADG utilisés pour traiter les troubles de santé mentale en pédiatrie. Toutefois, leurs avantages ne sont pas sans risques : on observe à la fois des effets secondaires métaboliques et neurologiques chez les enfants traités au moyen d’ADG. Le risque de prise de poids, d’augmentation de l’indice de masse corporelle et de taux lipidiques anormaux est plus élevé à l’utilisation d’olanzapine, suivie de la clozapine et de la quétiapine. Quant au risque d’effets secondaires neurologiques des traitements, il est plus élevé à l’utilisation de rispéridone, d’olanzapine et d’aripiprazole. Des interventions de surveillance pertinentes des effets secondaires amélioreront la qualité des soins des enfants traités à l’aide de ces médicaments. PMID:24082813

  1. Animations proposes par le Jardin Botanique en fonction des programmes scolaires

    E-print Network

    Jeanjean, Louis

    Animations proposées par le Jardin Botanique en fonction des programmes scolaires des 3 cycles de d'une espèce et ses propres besoins. Exemple d'animation : Activité « le petit explorateur, colorier des silhouettes, des modèles. Pour les GS, écriture des nouveaux mots de la thématique. Devenir

  2. FONCTIONS DE PARTITION DU MODLE D'ISING ET DES ARBRES COUVRANTS CRITIQUES

    E-print Network

    Marckert, Jean-François

    cercle de rayon 1 et que les centres des cercles soient à l'intérieur des faces (Duffin plan de sorte que toutes ses faces soient inscrites dans un cercle de rayon 1 et que les centres des inscrites dans un cercle de rayon 1 et que les centres des cercles soient à l'intérieur des faces (Duffin

  3. [P-Demo1.4] Traitement Automatique des Langues Naturelles, Marseille, 2014

    E-print Network

    for criteria for text filtering. Mots-clés : arabe, automates, analyseurs, opérateurs linguistiques, mots'automates exprimant des règles morphosyntaxiques et des opérateurs de détection des relations discursives - 2 - des objectif de montrer : - a - la richesse des ressources linguistiques - b - le souplesse de leur utilisation

  4. Characterization of a tumor necrosis factor. alpha. (TNF-. alpha. ) inhibitor: Evidence of immunological cross-reactivity with the TNF receptor

    SciTech Connect

    Seckinger, P.; Zhang, Jianhua; Hauptmann, B.; Dayer, J.M. )

    1990-07-01

    Previous studies have shown that urine of febrile patients contains a tumor necrosis factor {alpha} inhibiting activity (TNF-{alpha} Inh) when tested in a cytotoxicity assay using the tumor necrosis factor {alpha} (TNF-{alpha})-susceptible cell line L929. In the present study, the authors investigated the relationship between the TNF-{alpha} Inh and a potential soluble form of the receptor, as the former has been shown to block TNF-{alpha} activities by binding to the ligand. They demonstrate that human TNF-{alpha} is affected to a greater extent than is murine TNF-{alpha}. This species specificity of the inhibitor correlates with the binding studies of TNF receptor interactions already reported. They raised a polyclonal antibody to TNF-{alpha} Inh that neutralizes its activity and does not recognize TNF-{alpha}. Solubilized cross-linked {sup 125}I-labeled TNF-{alpha} receptor complex could be immunoprecipitated by using either anti-TNF-{alpha} or anti-TNF-{alpha} Inh antibody, suggesting immunological cross-reactivity between the receptor and the inhibitor. By using fluorescein isothiocyanate-coupled TNF-{alpha}, it was possible to visualize by fluorescence-activated cell sorter analysis the TNF-{alpha} receptor on phytohemagglutinin/interleukin 2-activated T cells. A similar increase of immunofluorescence intensity of the activated T cells was observed by using anti-TNF-{alpha} Inh antibody revealed with a fluorescein isothiocyanate-coupled goat anti-rabbit IgG1 conjugate, suggesting that the TNF-{alpha} Inh is also expressed as a membrane protein. Taken together, their results suggest that the TNF-{alpha} Inh originally described might be a soluble form of the TNF receptor itself.

  5. Etude theorique et experimentale des evaporateurs de dioxyde de carbone operant dans des conditions de givrage

    NASA Astrophysics Data System (ADS)

    Bendaoud, Adlane Larbi

    Les evaporateurs de refrigeration sont surtout du type tube a ailettes, appeles serpentins, et fonctionnent dans l'une des conditions suivantes: seche, humide ou avec formation de givre. Il a ete demontre que la formation du givre sur la paroi exterieure de l'echangeur engendre une surconsommation energetique a cause des operations de degivrage puisque 15 a 20% seulement de la chaleur produite sert au degivrage tandis que le reste est dissipee dans l'environnement [1]. Avec l'avenement des nouveaux refrigerants, moins nocifs envers l'environnement, l'industrie du froid se trouve penalisee du fait que peu ou pas de composantes mecaniques (compresseur, pompe, echangeur...etc.) adaptees sont disponibles [3]. Il s'agit pour la communaute des frigoristes de combler ce retard technologique en redeveloppant ces composantes mecaniques afin qu'elles soient adaptees aux nouveaux refrigerants. Dans cette optique, et afin de mieux comprendre le comportement thermique des evaporateurs au CO2 fonctionnant dans des conditions seches, qu'un groupe de chercheurs du CanmetENERGIE avaient lance, en 2000, un programme de R & D. Dans le cadre de programme un outil de simulation des evaporateurs au CO2 a ete developpe et un banc d'essai contenant une boucle secondaire de refrigeration utilisant le CO2 comme refrigerant a ete construit. Comme continuite de ce travail de recherche, en 2006 ce meme groupe de recherche a lance un nouveau projet qui consiste a faire une etude theorique et experimentale des evaporateurs au CO2 operants dans des conditions de givrage. Et, c'est exactement dans le cadre de ce projet que se positionne ce travail de these. Ce travail de recherche a ete entrepris pour mieux comprendre le comportement thermique et hydrodynamique des serpentins fonctionnant dans des conditions de givrage, l'effet des circuits de refrigerant ainsi que celui des parametres geometriques et d'operation. Pour cela, un travail theorique supporte par une etude experimentale a ete effectue. Dans la partie theorique, un modele traitant les aspects thermique, hydrodynamique et massique a ete elabore. Sur la base de ce modele a ete ecrit un programme informatique en langage FORTRAN 6.6. Il est base sur la discretisation du serpentin en volumes de controle, est entierement automatise et peut traiter des echangeurs de chaleur avec des circuits de refrigerant complexes pouvant avoir des entrees et sorties multiples ainsi que des bifurcations. La presence simultanee des trois phases thermodynamiques du refrigerant (liquide sous refroidi, fluide sature, vapeur surchauffee) dans le serpentin est aussi prise en charge. Le modele a ete valide pour un fonctionnement avec et sans formation de givre en utilisant des donnees experimentales disponibles dans la litterature et celles obtenues sur le banc d'essai de CanmetENERGIE. Celui-ci a ete mis a jour pour les besoins de la presente recherche et pour cela, un systeme de surchauffe et d'injection de la vapeur d'eau dans une enceinte a tres basse temperature a ete dimensionne, fabrique et installe. Un dispositif de visualisation de la formation de givre, ainsi qu'un equipement de mesure de la temperature, de la pression et de l'humidite relative de l'air ont aussi ete ajoutes. Une fois le modele valide, des simulations numeriques sur le serpentin avec et sans formation de givre ont ete effectuees. Un premier cas de base a servi comme reference pour d'autres cas pour lesquels une etude parametrique sur la geometrie et le fonctionnement a ete menee. Il a ete montre par rapport au cas de base que : 1. la diminution de la densite des ailettes sur des rangees specifiques du serpentin donne une surface minimale (Amin) plus grande, retardant ainsi l'obstruction totale du serpentin par le givre et permet donc un temps de fonctionnement plus grand et une frequence de degivrage plus faible. 2. une bonne configuration de circuit de refrigerant augmente le temps de fonctionnement du serpentin de 200 % et delivre une puissance frigorifique moyenne superieures de 20 % par rapport a celle du cas de base. 3. la diminution d

  6. Production of alpha-amylase by yeast

    SciTech Connect

    Thomse, K.K.

    1987-01-01

    The enzyme alpha-amylase confers to an organism the enzymatic activity for the degradation of polyglucosides with alpha-1,4 glycosidic bonds such as starch and glycogen which are among the major storage compounds in plants and animals. Most alpha-amylases are single polypeptides of molecular weights around 50,000 dalton. They are generally found in the digestive tract of animals and in germinating seeds. Among the products released upon enzymatic degradation of polyglucosides maltose, a sugar that can be utilized as carbon source by yeast, is a major constituent. A cDNA segment complementary to mouse salivary amylase messenger RNA has been inserted into the yeast expression vector pMA56 behind the promoter of the gene encoding alcohol dehydrogenase I of yeast. Yeast transformants harboring plasmids with the normal orientation of the promoter and the mouse amylase cDNA gene produce amylase and release the enzyme in free form into the culture medium. Approximately 90% of the amylase activity is found in the medium. Yeast strains carrying MAL allele and transformed with a plasmid which directed the synthesis of mouse alpha-amylase were tested on plates containing starch and in batch fermentations using different high molecular weight sugars and oligosaccharides as carbon source. The results of these experiments will be discussed. (Refs. 21).

  7. Alpha decay chains from superheavy nuclei

    E-print Network

    C. Samanta

    2008-11-11

    Magic islands for extra-stable nuclei in the midst of the sea of fission-instability were predicted to be around Z=114, 124 or, 126 with N=184, and Z=120, with N=172. Whether these fission-survived superheavy nuclei with high Z and N would live long enough for detection or, undergo alpha-decay in a very short time remains an open question. Alpha-decay half lives of nuclei with 130 100 have been calculated in a WKB framework using density-dependent M3Y interaction with Q-values from different mass formulae. The results are in excellent agreement with the experimental data. Fission survived Sg nuclei with Z=106, N=162 is predicted to have the highest alpha-decay half life ~ 3.2 hrs in the Z=106-108, N=160-164 region called, small island/peninsula. Superheavy nuclei with Z > 118 are found to have alpha-decay half lives of the order of microseconds or, less.

  8. Coefficient Alpha and Reliability of Scale Scores

    ERIC Educational Resources Information Center

    Almehrizi, Rashid S.

    2013-01-01

    The majority of large-scale assessments develop various score scales that are either linear or nonlinear transformations of raw scores for better interpretations and uses of assessment results. The current formula for coefficient alpha (a; the commonly used reliability coefficient) only provides internal consistency reliability estimates of raw…

  9. Serum alpha 1 antitrypsin and pulmonary emphysema.

    PubMed

    Shahid, A; Siddiqui, A A; Aziz, S; Ansari, M; Zuberi, S J; Waqar, M A

    1996-05-01

    Using isoelectric focusing (IEF) and radial immunodiffusion (RID) techniques, serum samples from 100 normal healthy adults and 21 patients with pulmonary emphysema were analysed to identify various alpha 1 antitrypsin phenotypes and the serum concentrations. Ten percent of the patients had low serum values. The normal or most common genetic form, MM, is the predominant phenotype in both controls and patients. PMID:8961698

  10. Cytokine therapeutics: lessons from interferon alpha.

    PubMed Central

    Gutterman, J U

    1994-01-01

    Cytokines are soluble proteins that allow for communication between cells and the external environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. This review focuses on the biological and clinical activities of the cytokine. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. The principles learned from in vivo studies will be discussed, particularly hairy cell leukemia, chronic myelogenous leukemia, certain angiogenic diseases, and hepatitis. After the surprising discovery of activity in a rare B-cell neoplasm, IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation. Regulatory agencies throughout the world have approved IFN-alpha for treatment of 13 malignant and viral disorders. The principles established with this cytokine serve as a paradigm for future development of natural proteins for human disease. PMID:8108387

  11. Understanding a Widely Misunderstood Statistic: Cronbach's "Alpha"

    ERIC Educational Resources Information Center

    Ritter, Nicola L.

    2010-01-01

    It is important to explore score reliability in virtually all studies, because tests are not reliable. The present paper explains the most frequently used reliability estimate, coefficient alpha, so that the coefficient's conceptual underpinnings will be understood. Researchers need to understand score reliability because of the possible impact…

  12. Shedding Lyman Alpha Light on Cosmological Reionization

    NASA Astrophysics Data System (ADS)

    Rhoads, James E.; Malhotra, Sangeeta; Ammons, S. Mark; Dressler, Alan; Gonzalez, Alicia; Finkelstein, Steven; Hibon, Pascale; Jiang, Tianxing; Lee, Janice; Mobasher, Bahram; Monson, Andy; Persson, S. Eric; Probst, Ronald; Swaters, Rob; Tilvi, Vithal S.; Veilleux, Sylvain; Wang, Junxian; Zabludoff, Ann; Zheng, Zhenya

    2015-08-01

    Lyman alpha photons are a powerful tool for studying reionization. They interact strongly with neutral hydrogen, so that neutral intergalactic gas acts to hide Lyman alpha light from our instruments. I will discuss two ongoing narrowband surveys to study the Epoch of Reionization. The Deep And Wide Narrowband (DAWN) survey is a 40 night NOAO survey program to look for Lyman alpha emission at redshift 7.7, using the NEWFIRM camera on the 4m Mayall Telescope at Kitt Peak National Observatory. The First Light And Reionization Experiment (FLARE) is pursuing a corresponding survey at redshift 8.8, using the FourStar camera on the Magellan telescope. Both surveys are motivated by the application of Lyman alpha lines to the study of reionization. Reionization marked the first global impact that gravitationally bound objects (stars and/or black holes) had on the universe around them, and also the last time that most hydrogen atoms did anything noteworthy. I will present results from both the DAWN and FLARE surveys, which have identified candidate galaxies near redshifts 7.7 and 8.8 in multiple fields.

  13. Alpha-glucosidase inhibitor from Chinese aloes.

    PubMed

    Jong-Anurakkun, Nilubon; Bhandari, Megh Raj; Hong, Gao; Kawabata, Jun

    2008-09-01

    Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively. PMID:18508205

  14. Systemic Targeted Alpha Radiotherapy for Cancer

    PubMed Central

    Allen, BJ

    2013-01-01

    Background: The fundamental principles of internal targeted alpha therapy forcancer were established many decades ago.The high linear energy transfer (LET) ofalpha radiation to the targeted cancer cellscauses double strand breaks in DNA. Atthe same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and chemotherapy. Such therapies fail on several fronts, such as lack of control of some primary cancers (e.g. glioblastoma multiforme) and to inhibit the development of lethal metastaticcancer after successful treatment of the primary cancer. Objective: This review charts the developing role of systemic high LET, internalradiation therapy. Method: Targeted alpha therapy is a rapidly advancing experimental therapy thatholds promise to deliver high cytotoxicity to targeted cancer cells. Initially thoughtto be indicated for leukemia and micrometastases, there is now evidence that solidtumors can also be regressed. Results: Alpha therapy may be molecular or physiological in its targeting. Alphaemitting radioisotopes such as Bi-212, Bi-213, At-211 and Ac-225 are used to labelmonoclonal antibodies or proteins that target specific cancer cells. Alternatively, Radium-233 is used for palliative therapy of breast and prostate cancers because of its bone seeking properties. Conclusion: Preclinical studies and clinical trials of alpha therapy are discussedfor leukemia, lymphoma, melanoma, glioblastoma multiforme, bone metastases, ovarian cancer, pancreatic cancer and other cancers. PMID:25505750

  15. MCNP S(. alpha. beta. ) detector scheme

    SciTech Connect

    Hendricks, J.S.; Prael, R.E.

    1990-10-01

    An approximate method to allow S({alpha},{Beta}) thermal collision contributions to point detectors and DXTRAN by Prael has been implemented in MCNP4. The method is described and test results are presented, including some results that indicate inadequacies in the NJOY processing of the nuclear data. 9 refs., 53 figs., 6 tabs.

  16. Method of making nanocrystalline alpha alumina

    DOEpatents

    Siegel, Richard W. (Hinsdale, IL); Hahn, Horst (Champaign, IL); Eastman, Jeffrey A. (Woodridge, IL)

    1992-01-01

    Method of making selected phases of nanocrystalline ceramic materials. Various methods of controlling the production of nanocrystalline alpha alumina and titanium oxygen phases are described. Control of the gas atmosphere and use of particular oxidation treatments give rise to the ability to control the particular phases provided in the aluminum/oxygen and titanium/oxygen system.

  17. Transformer Recharging with Alpha Channeling in Tokamaks

    SciTech Connect

    N.J. Fisch

    2009-12-21

    Transformer recharging with lower hybrid waves in tokamaks can give low average auxiliary power if the resistivity is kept high enough during the radio frequency (rf) recharging stage. At the same time, operation in the hot ion mode via alpha channeling increases the effective fusion reactivity. This paper will address the extent to which these two large cost saving steps are compatible. __________________________________________________

  18. EEG alpha power and creative ideation?

    PubMed Central

    Fink, Andreas; Benedek, Mathias

    2014-01-01

    Neuroscientific studies revealed first insights into neural mechanisms underlying creativity, but existing findings are highly variegated and often inconsistent. Despite the disappointing picture on the neuroscience of creativity drawn in recent reviews, there appears to be robust evidence that EEG alpha power is particularly sensitive to various creativity-related demands involved in creative ideation. Alpha power varies as a function of creativity-related task demands and the originality of ideas, is positively related to an individuals’ creativity level, and has been observed to increase as a result of creativity interventions. Alpha increases during creative ideation could reflect more internally oriented attention that is characterized by the absence of external bottom-up stimulation and, thus, a form of top-down activity. Moreover, they could indicate the involvement of specific memory processes such as the efficient (re-)combination of unrelated semantic information. We conclude that increased alpha power during creative ideation is among the most consistent findings in neuroscientific research on creativity and discuss possible future directions to better understand the manifold brain mechanisms involved in creativity. PMID:23246442

  19. New and efficient syntheses of alpha-iodo-alpha,alpha-difluoro- and beta-iodo-alpha,alpha,beta,beta-tetrafluorocarboxylic acid derivatives as useful building blocks for making functional fluoro compounds.

    PubMed

    Hung, Ming-H; Long, Lu; Yang, Zhen-Yu

    2004-01-01

    Perfluoroolefins reacted with I-Cl and ClSO(3)H under mild conditions to give R(F)CFICF(2)OSO(2)Cl, which could be readily converted into various alpha-iodo-perfluorocarboxylic acid derivatives or telomerized with tetrafluoroethylene to I(CF(2)CF(2))(n)()OSO(2)Cl. Ring-opening reaction of perfluoroalkoxypentafluorocyclopropane with iodine at 240 degrees C produced ICF(2)CF(2)COF, which was quenched by alcohol, water, or NH(3) to give beta-iodo-alpha,alpha,beta,beta-tetrafluorocarboxylic acid derivatives. These functional fluorinated iodides can be used as building blocks for making selectively fluorinated compounds. PMID:14703399

  20. Les effets des interfaces sur les proprietes magnetiques et de transport des multicouches nickel/iron et cobalt/silver

    NASA Astrophysics Data System (ADS)

    Veres, Teodor

    Cette these est consacree a l'etude de l'evolution structurale des proprietes magnetiques et de transport des multicouches Ni/Fe et nanostructures a base de Co et de l'Ag. Dans une premiere partie, essentiellement bibliographique, nous introduisons quelques concepts de base relies aux proprietes magnetiques et de transport des multicouches metalliques. Ensuite, nous presentons une breve description des methodes d'analyse des resultats. La deuxieme partie est consacree a l'etude des proprietes magnetiques et de transport des multicouches ferromagnetiques/ferromagnetiques Ni/Fe. Nous montrerons qu'une interpretation coherente de ces proprietes necessite la prise en consideration des effets des interfaces. Nous nous attacherons a mettre en evidence, a evaluer et a etudier les effets de ces interfaces ainsi que leur evolution, et ce, suite a des traitements thermiques tel que le depot a temperature elevee et l'irradiation ionique. Les analyses correlees de la structure et de la magnetoresistance nous permettront d'emettre des conclusions sur l'influence des couches tampons entre l'interface et le substrat ainsi qu'entre les couches elles-memes sur le comportement magnetique des couches F/F. La troisieme partie est consacree aux systemes a Magneto-Resistance Geante (MRG) a base de Co et Ag. Nous allons etudier l'evolution de la microstructure suite a l'irradiation avec des ions Si+ ayant une energie de 1 MeV, ainsi que les effets de ces changements sur le comportement magnetique. Cette partie debutera par l'analyse des proprietes d'une multicouche hybride, intermediaire entre les multicouches et les materiaux granulaires. Nous analyserons a l'aide des mesures de diffraction, de relaxation superparamagnetique et de magnetoresistance, les evolutions structurales produites par l'irradiation ionique. Nous etablirons des modeles qui nous aideront a interpreter les resultats pour une serie des multicouches qui couvrent un large eventail de differents comportements magnetiques et ceci en fonction de l'epaisseur de la couche magnetique de Co. Nous verrons que dans ces systemes les effets de l'irradiation ionique sont fortement influences par l'energie de surface ainsi que par l'enthalpie de formation, largement positive pour le systeme Co/Ag.

  1. Etude du processus de changement vecu par des familles ayant decide d'adopter volontairement des comportements d'attenuation des changements climatiques

    NASA Astrophysics Data System (ADS)

    Leger, Michel T.

    Les activites humaines energivores telles l'utilisation intensive de l'automobile, la surconsommation de biens et l'usage excessif d'electricite contribuent aux changements climatiques et autres problemes environnementaux. Bien que plusieurs recherches rapportent que l'etre humain est de plus en plus conscient de ses impacts sur le climat de la planete, ces memes recherches indiquent qu'en general, les gens continuent a se comporter de facon non ecologique. Que ce soit a l'ecole ou dans la communaute, plusieurs chercheurs en education relative a l'environnement estiment qu'une personne bien intentionnee est capable d'adopter des comportements plus respectueux de l'environnement. Le but de cette these etait de comprendre le processus d'integration de comportements d'attenuation des changements climatiques dans des familles. A cette fin, nous nous sommes fixe deux objectifs : 1) decrire les competences et les procedes qui favorisent l'adoption de comportements d'attenuation des changements climatiques dans des familles et 2) decrire les facteurs et les dynamiques familiales qui facilitent et limitent l'adoption de comportements d'attenuation des changements climatiques dans des familles. Des familles ont ete invitees a essayer des comportements personnels et collectifs d'attenuation des changements climatiques de sorte a integrer des modes de vie plus ecologiques. Sur une periode de huit mois, nous avons suivi leur experience de changement afin de mieux comprendre comment se produit le processus de changement dans des familles qui decident volontairement d'adopter des comportements d'attenuation des changements climatiques. Apres leur avoir fourni quelques connaissances de base sur les changements climatiques, nous avons observe le vecu de changement des familles durant huit mois d'essais a l'aide de journaux reflexifs, d'entretiens d'explicitation et du journal du chercheur. La these comporte trois articles scientifiques. Dans le premier article, nous presentons une recension des ecrits sur le changement de comportement en environnement. Nous explorons egalement la famille comme systeme fonctionnel de sorte a mieux comprendre ce contexte d'action environnementale qui est, a notre connaissance, peu etudie. Dans le deuxieme article, nous presentons nos resultats de recherche concernant les facteurs d'influence observes ainsi que les competences manifestees au cours du processus d'adoption de nouveaux comportements environnementaux dans trois familles. Enfin, le troisieme article presente les resultats du cas d'une quatrieme famille ou les membres vivent depuis longtemps des modes de vie ecologique. Dans le cadre d'une demarche d'analyse par theorisation ancree, l'etude de ce cas modele nous a permis d'approfondir les categories conceptuelles identifiees dans le deuxieme article de sorte a produire une modelisation de l'integration de comportements environnementaux dans le contexte de la famille. Les conclusions degagees grace a la recension des ecrits nous ont permis d'identifier les elements qui pourraient influencer l'adoption de comportements environnementaux dans des familles. La recension a aussi permis une meilleure comprehension des divers facteurs qui peuvent affecter l'adoption de comportements environnementaux et, enfin, elle a permis de mieux cerner le phenomene de changement de comportement dans le contexte de la famille consideree comme un systeme. En appliquant un processus d'analyse inductif, a partir de nos donnees qualitatives, les resultats de notre etude multi-cas nous ont indique que deux construits conceptuels semblent influencer l'adoption de comportements environnementaux en famille : 1) les valeurs biospheriques communes au sein de la famille et 2) les competences collectivement mises a profit collectivement durant l'essai de nouveaux comportements environnementaux. Notre modelisation du processus de changement dans des familles indique aussi qu'une dynamique familiale collaborative et la presence d'un groupe de soutien exterieur sont deux elements conceptuels qui tendent a influencer les deux princi

  2. Who Is at Risk for Alpha-1 Antitrypsin Deficiency?

    MedlinePLUS

    ... on Twitter. Who Is at Risk for Alpha-1 Antitrypsin Deficiency? Alpha-1 antitrypsin (AAT) deficiency occurs in all ethnic groups. ... it doesn't mean that you'll develop one of the diseases related to the condition. Some ...

  3. An assay for intermolecular exchange of alpha crystallin

    NASA Technical Reports Server (NTRS)

    Gopalakrishnan, S.; Takemoto, L.; Spooner, B. S. (Principal Investigator)

    1992-01-01

    An affinity column of alpha crystallin linked to cyanogen bromide-activated Sepharose was developed to study the exchange of alpha subunits. Alpha crystallin bound to the Sepharose-alpha complex was dissociated with 8 mol/l urea, followed by quantitation using high-performance reverse-phase liquid chromatography. The time course of binding at 37 degrees C showed a hyperbolic binding pattern reaching equilibrium between 6-18 hr. Under these conditions, binding of beta and gamma crystallins to the same matrix was less than 10% of the alpha values, as was binding of alpha to glycine-coupled Sepharose. This assay was used to demonstrate changes in the subunit exchange of alpha crystallins present in high molecular weight versus lower molecular weight aggregates of the human lens. These results show that this binding procedure was a specific reproducible assay that might be used to study intermolecular interactions of the alpha crystallins.

  4. Alpha clustering and weak coupling in the A=90 region

    E-print Network

    Ohkubo, S

    2011-01-01

    From the viewpoint of a unified description of cluster structure and scattering in the A=90 region, $\\alpha$ scattering from $^{89}$Y is investigated. $\\alpha$ clustering and weak coupling in $^{93}$Nb is discussed.

  5. Synthesis of 15 alpha-hydroxyestrogen 15-N-acetylglucosaminides.

    PubMed

    Suzuki, E; Namba, S; Kurihara, H; Goto, J; Matsuki, Y; Nambara, T

    1995-03-01

    The synthesis of 15-N-acetylglucosaminides of 15 alpha-hydroxyesterone, 15 alpha-hydroxyestradiol, and 15 alpha-hydroxyestriol (estetrol) is described. The latter two were prepared by condensation of 2-acetamido-1 alpha-chloro-1,2-dideoxy-3,4,6-trio-O-acetyl-D-glucopyranose with appropriately protected 15 alpha-hydroxyestrogens by the Koenigs-Knorr reaction employing cadmium carbonate as a catalyst. Subsequent removal of protecting groups with methanolic potassium hydroxide provided the desired conjugates. 15 alpha-Hydroxyestrone 15-N-acetylglucosaminide was synthesized from the corresponding 15 alpha-hydroxyestradiol derivative by Jones oxidation followed by brief alkaline hydrolysis. These conjugates underwent enzymatic hydrolysis with beta-N-acetylglucosaminidase from Jack beans to produce 15 alpha-hydroxyestrogens. PMID:7792832

  6. Study of alpha background in a dark matter detector

    E-print Network

    Yegoryan, Hayk

    2010-01-01

    Alpha background, specifically from radon and its progeny in the uranium and thorium chains, has been a major issue in dark matter detectors. This work focuses on alpha background presence in the DMTPC experiment by examining ...

  7. Antibody-mediated reduction of .alpha.-ketoamides

    DOEpatents

    Schultz, Peter G. (Oakland, CA); Gallop, Mark A. (East Palo Alto, CA)

    1998-01-01

    Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an .alpha.-ketoamide to the corresponding .alpha.-hydroxyamide in the presence of an appropriate reducing agent.

  8. 29 CFR 1915.1004 - alpha-Naphthylamine.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    29 Labor 7 2010-07-01 2010-07-01 false alpha-Naphthylamine. 1915.1004 Section 1915.1004 Labor...EMPLOYMENT Toxic and Hazardous Substances § 1915.1004 alpha-Naphthylamine. Note: The requirements applicable...

  9. 29 CFR 1926.1104 - alpha-Naphthylamine.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    29 Labor 8 2010-07-01 2010-07-01 false alpha-Naphthylamine. 1926.1104 Section 1926.1104 Labor...CONSTRUCTION Toxic and Hazardous Substances § 1926.1104 alpha-Naphthylamine. Note: The requirements applicable...

  10. Antibody-mediated reduction of {alpha}-ketoamides

    DOEpatents

    Schultz, P.G.; Gallop, M.A.

    1998-06-09

    Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an {alpha}-ketoamide to the corresponding {alpha}-hydroxyamide in the presence of an appropriate reducing agent.

  11. Dynamic alpha-invariants of del Pezzo surfaces with boundary 

    E-print Network

    Martinez Garcia, Jesus; Garcia, Jesus Martinez

    2013-11-28

    The global log canonical threshold, algebraic counterpart to Tian's alpha-invariant, plays an important role when studying the geometry of Fano varieties. In particular, Tian showed that Fano manifolds with big alpha-invariant ...

  12. Peroxisome proliferator-activated receptor {alpha}-independent peroxisome proliferation

    SciTech Connect

    Zhang Xiuguo; Tanaka, Naoki . E-mail: naopi@hsp.md.shinshu-u.ac.jp; Nakajima, Takero; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi

    2006-08-11

    Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPAR{alpha}-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPAR{alpha} dependence in the assay system. Surprisingly, a novel type of PPAR{alpha}-independent peroxisome proliferation and enlargement was uncovered in PPAR{alpha}-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11{alpha}, might be associated with the PPAR{alpha}-independent peroxisome proliferation at least in part.

  13. Nuclear isospin asymmetry in $\\alpha$ decays of heavy nuclei

    E-print Network

    Shin, Eunkyoung; Hyun, Chang Ho; Oh, Yongseok

    2015-01-01

    The effects of nuclear isospin asymmetry on $\\alpha$ decay lifetimes of heavy nuclei are investigated within various phenomenological models of nuclear potential for the $\\alpha$ particle. We consider the widely used simple square well potential and Woods-Saxon potential, and modify them by including an isospin asymmetry term. We then suggest a model for the potential of the $\\alpha$ particle motivated by a microscopic phenomenological approach of the Skyrme force model, which naturally introduce the isospin dependent form of the nuclear potential for the $\\alpha$ particle. The empirical $\\alpha$ decay lifetime formula of Viola and Seaborg is also modified to include isospin asymmetry effects. The obtained $\\alpha$ decay half-lives are in good agreement with the experimental data and we find that including the nuclear isospin effects somehow improves the theoretical results for $\\alpha$ decay half-lives. The implications of these results are discussed and the predictions on the $\\alpha$ decay lifetimes of sup...

  14. Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1

    PubMed Central

    1994-01-01

    The plasma protein fibronectin is an important opsonin in wound repair and host defense. To better understand the process of fibronectin- mediated phagocytosis, we have transfected K562 cells, which endogenously express alpha 5 beta 1, with alpha v beta 3. In these transfectants, antibodies to alpha v beta 3 block phagocytosis of fibronectin-opsonized beads completely, even though half the ingestion occurs through endogenous alpha 5 beta 1 receptors. alpha 5 beta 1- mediated adhesion to fibronectin-coated surfaces is unaffected by alpha v beta 3 ligation. Neither alpha v beta 5 nor alpha M beta 2 ligation affects alpha 5 beta 1 phagocytic function in transfectants expressing these receptors. Pharmacologic data suggest that alpha v beta 3 ligation suppresses the phagocytic competence of high affinity alpha 5 beta 1 receptors through a signal transduction pathway, perhaps involving protein kinase C. In addition to its significance for phagocytosis, alpha v beta 3 regulation of alpha 5 beta 1 function may be significant for its roles in cell migration, metastasis, and angiogenesis. PMID:7525603

  15. Removal of alpha-Gal epitopes from porcine aortic valve and pericardium using recombinant human alpha galactosidase A.

    PubMed

    Park, Seongsik; Kim, Woong-Han; Choi, Sun-Young; Kim, Yong-Jin

    2009-12-01

    It has been reported that the immune response due to alpha-Gal epitopes is an important factor in tissue valve failure. The elimination of the interaction between the natural anti-Gal antibodies and alpha-gal epitopes on the xenografts is a prerequisite to the success of xenografts in humans. Previously, we reported that the green coffee bean alpha-galactosidase could remove all alpha-Gal epitopes from cell surface of porcine aortic valve and pericardial tissue, but it has limitations on cost effectiveness. In this study we wanted to know whether the recently produced recombinant human alpha-galactosidase A has the same effective enzymatic activity as green coffee bean alpha-galactosidase in removing alpha-Gal epitopes from the same tissues. After treating fresh porcine aortic valve and pericardial tissue with recombinant alpha-galactosidase A, each sample was stained with Griffonia simplicifolia type I isolectin B4 indirect immunoperoxidase avidin-biotin technique. We then examined whether the alpha-Gal epitopes were reduced or abolished in each consecutive concentration of recombinant alpha-galactosidase A by comparing the degree of the Griffonia simplicifolia isolectin B4 staining. As a result, the recombinant alpha-galactosidase A could remove cell surface alpha-Gals on porcine aortic valve and pericardial tissue as effectively as green coffee bean alpha-galactosidase. PMID:19949670

  16. Chaperone-like activities of {alpha}-synuclein: {alpha}-Synuclein assists enzyme activities of esterases

    SciTech Connect

    Ahn, Misun; Kim, SeungBum; Kang, Mira; Ryu, Yeonwoo . E-mail: ywryu@ajou.ac.kr; Doohun Kim, T. . E-mail: doohunkim@ajou.ac.kr

    2006-08-11

    {alpha}-Synuclein, a major constituent of Lewy bodies (LBs), has been implicated to play a critical role in the pathogenesis of Parkinson's disease (PD), although the physiological function of {alpha}-synuclein has not yet been known. Here we have shown that {alpha}-synuclein, which has no well-defined secondary or tertiary structure, can protect the enzyme activity of microbial esterases against stress conditions such as heat, pH, and organic solvents. In particular, the flexibility of {alpha}-synuclein and its C-terminal region seems to be important for complex formation, but the structural integrity of the C-terminal region may not be required for stabilization of enzyme activity. In addition, atomic force microscopy (AFM) and in vivo enzyme assays showed highly specific interactions of esterases with {alpha}-synuclein. Our results indicate that {alpha}-synuclein not only protects the enzyme activity of microbial esterases in vitro, but also can stabilize the active conformation of microbial esterases in vivo.

  17. Possible stimulation of nuclear alpha-decay by superfluid helium

    E-print Network

    A. L. Barabanov

    2009-09-03

    It is suggested that superfluid helium (condensate of 4-He atoms) may stimulate nuclear alpha-decay in a situation when an alpha-emitter moves through superfluid helium with fine-tuned velocity, so that the backward-emitted alpha-particle is at rest in the laboratory frame. It is shown that the probability of stimulated alpha-decay in this case may be sizable enough to be detected.

  18. Wahlfach II: Sonographie des Abdomens Modul-Code: MSE_WP 568

    E-print Network

    Manstein, Dietmar J.

    Wahlfach II: Sonographie des Abdomens Modul-Code: MSE_WP 568 Wahlpflichtveranstaltung mit 5, empfohlen im Freitertial Lernziele Praktische Sonographie des Abdomens: Grundkenntnisse Gerätetechnik. Bildoptimierung. Sonographische Anatomie in ausgewählten Standardebenen des Abdomens. Selbständige Durchführung

  19. Les tannins : Les tannins (ou tanins, du franais tan, corce, mot issu du gaulois) sont des

    E-print Network

    . Enfin, des tannins particuliers, ou phlorotannins, existent chez les algues hétérocontes (Phéophytes ou'astringence en bouche des végétaux verts et des vins trop jeunes (réaction tannins vacuolaires / protéines

  20. Bayesian Statistical Inference for Coefficient Alpha. ACT Research Report Series.

    ERIC Educational Resources Information Center

    Li, Jun Corser; Woodruff, David J.

    Coefficient alpha is a simple and very useful index of test reliability that is widely used in educational and psychological measurement. Classical statistical inference for coefficient alpha is well developed. This paper presents two methods for Bayesian statistical inference for a single sample alpha coefficient. An approximate analytic method…

  1. Identification of an acetylation site of Chlamydomonas alpha-tubulin.

    PubMed Central

    LeDizet, M; Piperno, G

    1987-01-01

    An acetylation site of Chlamydomonas axonemal alpha-tubulins was identified near, or within, the binding site of 6-11B-1, a monoclonal antibody specific for posttranslationally acetylated alpha-tubulins. In a first approach, axonemal proteins were hydrolyzed by formic acid, cyanogen bromide, or chymotrypsin and analyzed with immunoblots. The smallest alpha-tubulin peptide retained on nitrocellulose and containing antibody-binding site(s) was found to span amino acids 37-138 (alpha 37-138). A smaller antibody-binding peptide, identified as alpha 25-50, was obtained by complete digestion of alpha-tubulin with chymotrypsin. This fragment was purified by reversed-phase HPLC and assayed by its ability to bind 6-11B-1 in solution. Determination of the amino acid sequences of alpha 37-138 and alpha 25-50 showed that residue 40 in axonemal alpha-tubulin is epsilon N-acetyllysine. A sequence very similar to Chlamydomonas alpha 25-50 is found in the majority of alpha-tubulins analyzed so far. However, the corresponding region is markedly divergent in some alpha-tubulin isoforms from chicken, Drosophila, and yeast. Images PMID:2441392

  2. Interaction between metabotropic glutamate receptor 7 and alpha tubulin

    E-print Network

    Hall, Randy A

    Interaction between metabotropic glutamate receptor 7 and alpha tubulin Julie A. Saugstad,* Sufang, with the cytoskeletal protein, alpha tubulin. The mGluR7 carboxy terminal (CT) region was expressed as a GST fusion microsequencing analysis revealed to be alpha tubulin. Coimmunoprecipitation assays confirmed that full-length m

  3. 40 CFR 721.10491 - Benzenepropanal,.alpha.-methyl-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Benzenepropanal,.alpha.-methyl-. 721... Substances § 721.10491 Benzenepropanal,.alpha.-methyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenepropanal,.alpha.-methyl- (PMN...

  4. 40 CFR 721.10491 - Benzenepropanal,.alpha.-methyl-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Benzenepropanal,.alpha.-methyl-. 721... Substances § 721.10491 Benzenepropanal,.alpha.-methyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzenepropanal,.alpha.-methyl- (PMN...

  5. The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein.

    PubMed

    Jinsmaa, Yunden; Cooney, Adele; Sullivan, Patricia; Sharabi, Yehonatan; Goldstein, David S

    2015-03-17

    In Parkinson's disease (PD) alpha-synuclein oligomers are thought to be pathogenic, and 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate aldehyde intermediate in neuronal dopamine metabolism, potently oligomerizes alpha-synuclein. PD involves alpha-synuclein deposition in brainstem raphe nuclei; however, whether 5-hydroxyindoleacetaldehyde (5-HIAL), the aldehyde of serotonin, oligomerizes alpha-synuclein has been unknown. In this study we tested whether 5-HIAL oligomerizes alpha-synuclein in vitro and in PC12 cells conditionally over-expressing alpha-synuclein. Alpha-synuclein oligomers were quantified by western blotting after incubation of alpha-synuclein with serotonin and monoamine oxidase-A (MAO-A) to generate 5-HIAL or dopamine to generate DOPAL. Oligomerization of alpha-synuclein in PC12 cells over-expressing the protein was compared between vehicle-treated cells and cells incubated with levodopa to generate DOPAL or 5-hydroxytryptophan to generate 5-HIAL. Monoamine aldehyde mediation of the oligomerization was assessed using the MAO inhibitor, pargyline. Dopamine and serotonin incubated with MAO-A both strongly oligomerized alpha-synuclein (more than 10 times control); pargyline blocked the oligomerization. In synuclein overexpressing PC12 cells, levodopa and 5-hydroxytryptophan elicited pargyline-sensitive alpha-synuclein oligomerization. 5-HIAL oligomerizes alpha-synuclein both in vitro and in synuclein-overexpressing PC12 cells, in a manner similar to DOPAL. The findings may help explain loss of serotonergic neurons in PD. PMID:25637699

  6. Factors Affecting Coefficient Alpha: A Mini Monte Carlo Study.

    ERIC Educational Resources Information Center

    Reinhardt, Brian M.

    Factors affecting a lower-bound estimate of internal consistency reliability, Cronbach's coefficient alpha, are explored. Theoretically, coefficient alpha is an estimate of the correlation between two tests drawn at random from a pool of items like the items in the test under consideration. As a practical matter, coefficient alpha can be an index…

  7. Direct Measurement of {sup 21}Na+{alpha} Stellar Reaction

    SciTech Connect

    Binh, D. N.; Kubono, S.; Yamaguchi, H.; Hayakawa, S.; Hashimoto, T.; Kahl, D.; Teranishi, T.; Iwasa, N.; Kume, N.; Kato, S.; Khiem, L. H.; Tho, N. T.; Wakabayashi, Y.

    2010-08-12

    The measurement of the resonant alpha scattering and the {sup 21}Na({alpha}, p) reaction were performed for the first time in inverse kinematics with the thick target method using a {sup 21}Na radioisotope (RI) beam. This paper reports the current result of alpha scattering measurement and its astrophysics implication.

  8. Formation en Aliments Sant et Technologie (FAST) Le programme FAST a comme mission de former des professionnels et des jeunes chercheurs

    E-print Network

    Formation en Aliments Santé et Technologie (FAST) Le programme FAST a comme mission de former des professionnels et des jeunes chercheurs ayant acquis non seulement une expertise de pointe en recherche, mais produits, de mise en marché et de réglementation. Le secteur des aliments santé et des technologies est

  9. Comportement rhéologique des systèmes mixtes biopolymères / protéines

    NASA Astrophysics Data System (ADS)

    Rebiha, M.; Moulai-Mostefa, N.; Sadok, A. Hadj; Sabri, N.

    2005-05-01

    Dans ce travail, on s'est intéressé à l'étude des effets du caséinate de sodium et du xanthane sur les propriétés rhéologiques des solutions aqueuses, préparées suivant un plan d'expériences. Les caractéristiques mécaniques obtenues sont traduites par les coefficients du modèle rhéologique de Casson, en l'occurrence la contrainte seuil, ? 0, et la viscosité plastique, ? _c. Ainsi, à l'issue de la modélisation en surface de réponses, il apparaît une interaction répulsive à l'échelle structurale entre le caséinate de sodium et le xanthane, traduite par un abaissement considérable de ? 0. Cet baissement de la rigidité peut conduire à une séparation de phases, phénomène conditionné par la viscosité limite de Casson,? _c.

  10. Plan stratgique 2015-2020 Facult des sciences

    E-print Network

    Laval, Université

    Plan stratégique 2015-2020 Faculté des sciences de l'agriculture et de l'alimentation #12;www.fsaa.ulaval.ca Notre mission La Faculté des sciences de l'agriculture et de l'alimentation est un acteur majeur dans le Faculté des sciences de l'agriculture et de l'alimentation par la richesse et l'expertise de ses membres

  11. BACCALAURAT COOPRATIF EN GNIE DES MINES ET DE LA MINRALURGIE

    E-print Network

    Laval, Université

    département GML-2002 Thermodynamique 3 H 4 PR : GML-1001 et MAT-1900 GGL-2601 Analyse et modélisation des, le cas échéant, aux exigences indiquées ci-après. I. COURS DE CONCENTRATION (15 crédits) Choisir l'une des deux concentrations (A ou B): A) EXPLOITATION MINI�RE (15 crédits) GCI-1002 Mécanique des sols I 3

  12. LE DEVENIR DES DOCTEURS DE L'UFC PROMOTION 2008

    E-print Network

    Jeanjean, Louis

    microtechniques (SPIM), Louis Pasteur, et Langages, espaces, temps, sociétés (LETS). Les profils différent selon première inscription en thèse. Louis Pasteur : deux tiers sont des hommes, la durée moyenne des thèses est, SPIM et Louis Pasteur, plus de 95 % des docteurs sont en emploi 3 ans après la soutenance de thèse

  13. Devenir des diplms de Master Recherche

    E-print Network

    Sart, Remi

    , une vue globalisée du devenir des diplômés de Master Recherche de l'Université Blaise Pascal, toutes spécialités confondues. Fiche 1 : Vue d'ensemble sur les Masters Recherche de l'Université Blaise Pascal Blaise Pascal #12;Région parisienne 3,8%(6) Limousin 2,5%(4) Rhône-Alpes 5,1%(8) Auvergne 67

  14. INAUGURATION DE LA CRECHE DES CEZEAUX

    E-print Network

    Sart, Remi

    INAUGURATION DE LA CRECHE DES CEZEAUX Clermont-Ferrand, le 13 octobre 2015 UNIVERSIT� BLAISE PASCAL porté par le PRES Clermont université, il est porté depuis janvier 2015 par l'Université Blaise Pascal. Tous les personnels et étudiants de l'Université Blaise Pascal sont éligibles à une place en crèche

  15. Devenir des diplms de Master Recherche

    E-print Network

    Sart, Remi

    leur diplôme. Concernant les Masters Recherche de l'Université Blaise Pascal, les 240 diplômés de la, une vue globalisée du devenir des diplômés de Master Recherche de l'Université Blaise Pascal, toutes spécialités confondues. Fiche 1 : Vue d'ensemble sur les Masters Recherche de l'Université Blaise Pascal

  16. Introduction l'architecture des ordinateurs

    E-print Network

    Silber, Georges-André

    be built on a single wafer." http://en.wikipedia.org/wiki/Moore's_law 1965 #12;Deuxième Loi de Moore 1975 Le nombre de transistors des microprocesseurs sur une puce de silicium double tous les deux ans. http://en.wikipedia.org/wiki/Moore's_law jusqu'à ce qu'il soit limité par la loi de Moore. Il n'atteindra jamais un stade de maturité

  17. Profil anthropometrique des enfants scolarises tananariviens

    PubMed Central

    Razafimanantsoa, Fetralinjiva; Razafindramaro, Notahiana; Raherimandimby, Hasina; Robinson, Annick; RakotoAlson, Olivat; Rasamindrakotroka, Andry

    2013-01-01

    Les enfants tananariviens sont en état de malnutrition chronique. Notre objectif est d’évaluer l'indice de masse corporelle (IMC) pour estimer les enfants apparemment "sains". Une enquête et une mesure de la taille et du poids des enfants scolarisés tananariviens de 6 à 11 ans ont été réalisées. Après leur accord, la taille et l'indice de masse corporelle des 442 enfants tirés au hasard ont été ainsi obtenus. L'analyse de la moyenne de la taille a révélé une différence significative à 8 ans, une différence non évidente sur l'indice de masse corporelle. La comparaison avec les valeurs de référence (OMS 2006) a montré un retard statural de 34% avec une tendance globale à la hausse et un déficit pondéral égal à 5,5% selon le z score. Ainsi, au sein d'une population malnutrie, l'indice de masse corporelle pourrait être utilisé comme un des paramètres à considérer dans l’évaluation de l’état de santé pour classer ces enfants en bonne santé apparente. PMID:24711862

  18. Newtons Universum. Materialien zur Geschichte des Kraftbegriffes.

    NASA Astrophysics Data System (ADS)

    Mit einem Vorwort von E. Seibold und einer Einführung von W. Neuser. This book is a selection of 15 articles published in the journal "Spektrum der Wissenschaft". The original English versions of the papers were first published in "Scientific American". Contents: 1. Impetustheorie und Intuition in der Physik (M. McCloskey). 2. Mittelalterliche Ursprünge der industriellen Revolution (T. S. Reynolds). 3. Leonardo da Vincis Beiträge zur theoretischen Mechanik (V. Foley, W. Soedel). 4. Nikolaus Kopernikus und Tycho Brahe (O. Gingerich). 5. Keplers Entdeckung der ersten beiden Planetengesetze (C. Wilson). 6. Galileis Entdeckung des Fallgesetzes (S. Drake). 7. Galileis Beobachtung des Neptun (S. Drake, C. T. Kowal). 8. Galileo Galilei und der Schatten des Giordano Bruno (L. S. Lerner, E. A. Gosselin). 9. Der Fall Galilei (O. Gingerich). 10. Newtons Apfel und Galileis "Dialog" (S. Drake). 11. Newtons Gravitationsgesetz - aus Formeln wird eine Idee (I. B. Cohen). 12. Christopher Wren: Astronom und Architekt (H. Dorn, R. Mark). 13. Atomismus und Kräfte in der Geschichte (L. Holliday). 14. Ein Elitezirkel vor 200 Jahren: Die Lunar Society von Birmingham (L. Ritchie-Calder). 15. Sadi Carnot: Technik und Theorie der Dampfmaschine (S. S. Wilson).

  19. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    Des mesures spectroscopiques effectuees avec un haut rapport signal sur bruit et une bonne resolution ont demontre l'existence de regions perturbees en mouvement dans le vent d'etoiles Wolf-Rayet (WR). L'echantillon d'objets etudies ici comprend 9 etoiles WR couvrant differents sous-types WN et WC. De nombreuses petites structures variables superposees au profil des raies d'emission formees dans le vent stellaire signalent la presence des perturbations. L'etude des variations globales des raies et l'examen des micro-structures individuelles ont permis de decrire plusieurs caracteristiques des perturbations. Entre autres, on observe des correlations significatives entre le niveau de variabilite des raies et certains parametres des etoiles qui confirment que le phenomene de variabilite est intrinseque au vent stellaire. En comparant les changements des vitesses radiales et des largeurs equivalentes des differentes raies d'une meme etoile, on conclut que les regions perturbees ont une etendue finie par rapport a l'enveloppe des etoiles. On peut facilement suivre les structures individuelles sur une periode de temps couvrant ~eq8 heures (et peut etre meme 24 heures) avant qu'elles ne disparaissent. Durant ce temps les structures se deplacent en s'eloignant du centre de la raie. A partir des differents comportements notes lors de l'analyse des variations globales et lors de l'examen des structures individuelles, on propose de representer les perturbations par un modele d'inhomogeneites discretes en expansion dans le vent. On suppose simplement que les inhomogeneites emettent comme le vent global (et absorbent aussi si le vent global montre un profil P Cyg). La superposition du graphique de l'acceleration radiale moyenne des inhomogeneites de WR140 en fonction de leur vitesse radiale et du modele theorique d'inhomogeneites qui suivent la loi generale de vitesse donne un taux d'acceleration lent, avec beta >= 3 pour les inhomogeneites de cette etoile. On obtient, entre autres, une correlation entre le nombre d'inhomogeneites detectees et la vitesse terminale. Cette relation explique bien l'anti-correlation observee entre le niveau de variabilite spectroscopique, photometrique ou polarimetrique et la vitesse terminale. On estime pour toutes les etoiles une masse moyenne des inhomogeneites de 7 times 10^{ -10} Modot et un taux de perte de masse sous la forme d'inhomogeneites detectables qui correspond a 10% de la perte de masse du vent total. L'histogramme du nombre d'inhomogeneites en fonction du leur flux pourrait cependant predire l'existence d'un grand nombre de petites structures non-detectees ici a cause du rapport signal sur bruit relativement trop faible. Ce resultat interessant, qui demande cependant a etre verifie, suggere que le vent pourrait etre forme d'un ensemble quasi infini d'inhomogeneites. En ajustant une loi de puissance dans l'histogramme du flux de chaque etoile, on calcule, pour les plus grosses structures, un exposant = -2.4 +/- 0.2. On constate alors que cette valeur est compatible avec celle que predit la turbulence supersonique. Les structures observees dans les spectres des etoiles WR ont des caracteristiques tres semblables a celles des etoiles O. On propose alors que les perturbations observees chez ces 2 types d'etoiles ont une meme origine. Parmi les mecanismes deja proposes dans le passe pour expliquer les variations des etoiles O et WR (instabilites radiatives, pulsations et champ magnetique) on ne saurait encore dire <=uel, ou lesquels, correspondent le mieux aux observations. Dans les projets futurs, on propose de considerer aussi le role que pourrait avoir la turbulence pour expliquer les perturbations du vent stellaire.

  20. Tritium diagnostics by Balmer-alpha emission

    SciTech Connect

    Skinner, C.H.; Ramsey, A.T.; Johnson, D.W.; Diesso, M.

    1993-02-01

    Spectral line emission from tritium in a plasma may be distinguished from deuterium emission by a small isotope shift. A diagnostic system to measure tritium Balmer-alpha emission from the plasma edge has been installed on TFTR. This system has been used in deuterium plasmas, and the deuterium alpha line profile used as a basis to predict the spectrum at differing tritium concentrations in future D-T runs. The tritium and deuterium lines are partially blended, however, analysis of the predicted D-T spectra by a line fitting program produced estimates of the tritium density that closely matched those input to the spectra, providing confidence that the tritium density can be reliably measured. The spectrum maps the tritium velocity distribution at the plasma edge and will be important for studies of tritium edge physics.

  1. Alpha Cluster Model of Atomic Nuclei

    E-print Network

    Zbigniew Sosin; Jan B?ocki; Jinesh Kallunkathariyil; Jerzy ?ukasik; Piotr Paw?owski

    2015-06-22

    The description of the nuclear system in its ground state and at low excitations based on the equation of state (EoS) around the saturation density is presented. In the expansion of the EoS around the saturation point additional spin polarization terms are taken into account. In addition for atomic nuclei a correction of the average nucleonic energy for the surface energy is introduced. The ground state configurations for the N=Z even-even nuclei, obtained with the proposed EoS, exhibit a clear cluster structure. At the nuclear surface these clusters can be identified as alpha particles. Taking into account an additional interaction between clusters the binding energy and sizes of the considered nuclei are very accurately described. From properties of the {\\alpha} particle, 3He and t limits of the EoS parameters are established.

  2. Project Longshot: A mission to Alpha Centauri

    NASA Technical Reports Server (NTRS)

    West, Curtis; Chamberlain, Sally; Pagan, Neftali; Stevens, Robert

    1989-01-01

    Project Longshot, an exercise in the Advanced Design Program for Space, had as its destination Alpha Centauri, the closest star system to our own solar system. Alpha Centauri, a trinary star system, is 4.34 light years from earth. Although Project Longshot is impossible based on existing technologies, areas that require further investigation in order to make this feat possible are identified. Three areas where advances in technology are needed are propulsion, data processing for autonomous command and control functions, and reliability. Propulsion, possibly by antimatter annihilation; navigation and navigation aids; reliable hardware and instruments; artificial intelligence to eliminate the need for command telemetry; laser communication; and a reliable, compact, and lightweight power system that converts energy efficiently and reliably present major challenges. Project Longshot promises exciting advances in science and technology and new information concerning the universe.

  3. The Ups and Downs of Alpha Centauri

    NASA Astrophysics Data System (ADS)

    Ayres, Thomas

    2014-11-01

    Nearby Alpha Centauri is destined for a pivotal chapter in human history, as first stop of future starfarers from Earth: 3x closer than the next nearest star; three very different objects to visit -- Alpha Cen A (G2V), B (K1V), and C (M6V); and B hosts an Earth-mass companion, albeit in a hot, lifeless orbit. For its part, Chandra has been keeping intent watch on the high-energy starspot cycles of AB, with semi-annual pointings over the past decade. Only HRC-I can separate AB as they plunge toward a close approach of 4" in 2016; and LETGS has countered that an abrupt 50x drop in XMM count rate of sun-like A in early 2005, ominously reported as the "darkening of the solar twin," simply is a soft sensitivity issue, not an unprecedented, inexplicable case of corona interrupta.

  4. Optical conductivity of alpha-Mn

    NASA Technical Reports Server (NTRS)

    Scoles, K. J.; Christy, R. W.

    1982-01-01

    The optical constants were measured at room temperature in the photon-energy range 0.6 to 6.5 eV on evaporated thin films. Evaporation conditions were chosen that gave the alpha-Mn crystal structure with reasonably large grains. The optical conductivity was separated into intraband and interband contributions by fitting to the Drude formula at low energies. The results are anomalous in comparison to other 3d transition metals. The free-electron lifetime is exceptionally sort (in agreement with the large dc resistivity of Mn), and the interband transitions seem unusually weak at the lower energies. Possible explanations related to the complicated crystal structure of alpha-Mn are discussed.

  5. Alpha-viscosity effects in slender tori

    E-print Network

    Horak, Jiri; Levin, Lina; Slapak, Rikard; Straub, Odele

    2012-01-01

    We explore effects of the Shakura-Sunyaev alpha-viscosity on the dynamics and oscillations of slender tori. We start with a slow secular evolution of the torus. We show that the angular-momentum profile approaches the Keplerian one on the timescale longer than a dynamical one by a factor of the order of 1/\\alpha. Then we focus our attention on the oscillations of the torus. We discuss effects of various angular momentum distributions. Using a perturbation theory, we have found a rather general result that the high-order acoustic modes are damped by the viscosity, while the high-order inertial modes are enhanced. We calculate a viscous growth rates for the lowest-order modes and show that already lowest-order inertial mode is unstable for less steep angular momentum profiles or very close to the central gravitating object.

  6. Automatically processed alpha-track radon monitor

    DOEpatents

    Langner, G.H. Jr.

    1993-01-12

    An automatically processed alpha-track radon monitor is provided which includes a housing having an aperture allowing radon entry, and a filter that excludes the entry of radon daughters into the housing. A flexible track registration material is located within the housing that records alpha-particle emissions from the decay of radon and radon daughters inside the housing. The flexible track registration material is capable of being spliced such that the registration material from a plurality of monitors can be spliced into a single strip to facilitate automatic processing of the registration material from the plurality of monitors. A process for the automatic counting of radon registered by a radon monitor is also provided.

  7. Alpha Cluster Model of Atomic Nuclei

    E-print Network

    Zbigniew Sosin; Jan B?ocki; Jinesh Kallunkathariyil; Jerzy ?ukasik; Piotr Paw?owski

    2015-12-10

    Description of a nuclear system in its ground state and at low excitations based on the equation of state (EoS) around normal density is presented. In the expansion of the EoS around the saturation point additional spin polarization terms are taken into account. A correction for the surface effects is introduced for atomic nuclei. The ground state configurations for the N=Z even-even nuclei, obtained with the proposed EoS, exhibit a clear cluster structure. At the nuclear surface these clusters can be identified as alpha particles. Taking into account an additional interaction between clusters the binding energies and sizes of the considered nuclei are very accurately described. The limits of the EoS parameters are established from the properties of the $\\alpha$, $^{3}He$ and $t$ particles.

  8. Automatically processed alpha-track radon monitor

    DOEpatents

    Langner, Jr., G. Harold (Mack, CO)

    1993-01-01

    An automatically processed alpha-track radon monitor is provided which includes a housing having an aperture allowing radon entry, and a filter that excludes the entry of radon daughters into the housing. A flexible track registration material is located within the housing that records alpha-particle emissions from the decay of radon and radon daughters inside the housing. The flexible track registration material is capable of being spliced such that the registration material from a plurality of monitors can be spliced into a single strip to facilitate automatic processing of the registration material from the plurality of monitors. A process for the automatic counting of radon registered by a radon monitor is also provided.

  9. Alpha ash transport and ash control

    SciTech Connect

    Miley, G.H.; Hu, S.C.; Varadarajan, V.

    1990-01-01

    This paper discusses: thermal {alpha}-particle transport is a crucial issue in ash buildup. The transport will determine if buildup prevents ignition and if external control is necessary. Due to uncertainties in the transport coefficients, 1-1/2-D sensitivity study of the influence on the fusion power density is done using the BALDUR code. The Baldur simulations with varying diffusion coefficients for ash plasma are performed. The results of ash transport in the presence of sawteeth and varying edge conditions are discussed. Also, the nature of the fishbone oscillation in the presence of two hot species consisting of hot alphas and beam injected ions is discussed. The sawteeth and fishbones can be potential mechanisms for enhanced ash transport; the latter will indirectly influence the ash transport.

  10. Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico.

    PubMed

    Jhong, Chien-Hung; Riyaphan, Jirawat; Lin, Shih-Hung; Chia, Yi-Chen; Weng, Ching-Feng

    2015-01-01

    The alpha-glucosidase inhibitor is a common oral anti-diabetic drug used for controlling carbohydrates normally converted into simple sugars and absorbed by the intestines. However, some adverse clinical effects have been observed. The present study seeks an alternative drug that can regulate the hyperglycemia by down-regulating alpha-glucosidase and alpha-amylase activity by molecular docking approach to screen the hyperglycemia antagonist against alpha-glucosidase and alpha-amylase activities from the 47 natural compounds. The docking data showed that Curcumin, 16-hydroxy-cleroda-3,13-dine-16,15-olide (16-H), Docosanol, Tetracosanol, Antroquinonol, Berberine, Catechin, Quercetin, Actinodaphnine, and Rutin from 47 natural compounds had binding ability towards alpha-amylase and alpha-glucosidase as well. Curcumin had a better biding ability of alpha-amylase than the other natural compounds. Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM). A natural compound with alpha-amylase inhibitors (below 0.5 mM) includes Curcumin, Berberine, Docosanol, 16-H, Actinodaphnine/Tetracosanol, Catechin, and Quercetin when compared to Acarbose (1 mM). When taken together, the implication is that molecular docking is a fast and effective way to screen alpha-glucosidase and alpha-amylase inhibitors as lead compounds of natural sources isolated from medicinal plants. PMID:26154585

  11. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.

    PubMed

    Dietrich, Christoph G; Martin, Ina V; Porn, Anne C; Voigt, Sebastian; Gartung, Carsten; Trautwein, Christian; Geier, Andreas

    2007-09-01

    Fasting induces numerous adaptive changes in metabolism by several central signaling pathways, the most important represented by the HNF4alpha/PGC-1alpha-pathway. Because HNF4alpha has been identified as central regulator of basolateral bile acid transporters and a previous study reports increased basolateral bile acid uptake into the liver during fasting, we hypothesized that HNF4alpha is involved in fasting-induced bile acid uptake via upregulation of basolateral bile acid transporters. In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting. Protein expression as determined by Western blot showed significant increases for all three transporters 72 h after the onset of fasting. Whereas binding activity of HNF1alpha in electrophoretic mobility shift assays remained unchanged, HNF4alpha binding activity to the Ntcp promoter was increased significantly. In line with this result, we found significantly increased mRNA expression of HNF4alpha and PGC-1alpha. Functional studies in HepG2 cells revealed an increased endogenous NTCP mRNA expression upon cotransfection with either HNF4alpha, PGC-1alpha, or a combination of both. We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. PMID:17640976

  12. Stereoisomeric inversion of (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acids in rat liver peroxisome.

    PubMed

    Ikegawa, S; Goto, T; Watanabe, H; Goto, J

    1995-07-01

    The stereoisomeric inversion of (25R)- and (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) in rat liver peroxisome was studied. After incubation of an isomer of THCA-CoA thioester with a peroxisomal fraction, 5 beta-cholestanoic acids were extracted and optical antipodes were separated and determined by LC/APCI-MS. The transformation of (24E)-3alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholest-24-en-26-oic acid (delta 24-THCA) formed by acyl-CoA oxidase was also analyzed by GC/NICI-MS. Rapid enzymatic epimerization from either direction was observed prior to biotransformation into (24E)-delta 24-THCA. PMID:7581245

  13. Prise en charge des complications des fistules artério-veineuses pour hémodialyse chronique

    PubMed Central

    Jiber, Hamid; Zrihni, Youssef; Zaghloul, Rachid; Hajji, Rita; Zizi, Othman; Bouarhroum, Abdellatif

    2015-01-01

    La fistule artério-veineuse native est l'accès vasculaire de choix pour l'hémodialyse chronique en raison de sa longévité, son taux faible de complication et de mortalité par rapport aux pontages artério-veineux et aux cathéters. Cependant, il arrive assez souvent que l'on assiste à des complications qui sont dominées par la sténose et la thrombose. C'est une étude rétrospective des complications ayants survenues pour 31 fistules artério-veineuses pour hémodialyse chronique des 200 fistules réalisées chez 200 patients au sein du service de chirurgie vasculaire du CHU Hassan II de Fès sur une période de trois ans, étendue de Janvier 2007 à Décembre 2009. Ces complications ont été présentés par les thromboses dans 14 cas soit 45,15% de l'ensemble des complications, les sténoses dans 4 cas (12,90%,) les anévrismes dans 4 cas (12,90%), les complications ischémiques dans 3 cas (9,67%), l'infection dans 3 cas (9,67%), l'hémorragie dans 2 cas (6,45%) et l’ hyperdébit dans un seul cas soit 3,22%. On a pu conserver 22 fistules soit 70,96% par traitement chirurgical ou endovasculaire, on a confectionné une nouvelle fistule dans 8 cas soit 25,80%, et on a adressé une patiente (3,22%) pour pose d'un cathéter veineux tunnelisé permanent. Les complications des fistules artério-veineuses pour l'hémodialyse chronique sont la principale cause de morbidité chez les patients hémodialysés, il est donc important de s'impliquer lors de leur création, et de donner un maximum d'attention quand ils sont manipulés. Ceci suggère la mise en place d'un programme de surveillance de ces fistules en raison de l'impact des complications sur la morbi-mortalité du patient hémodialysé et sur le plan financier. PMID:26113933

  14. Review of {alpha}{sub s} measurements

    SciTech Connect

    Burrows, P.N.

    1996-10-01

    Determinations of {alpha}{sub s} are reviewed. Current results are limited to a precision of around 3--20%, largely by theoretical uncertainties. All measurements are consistent with a world average value of 0.118 {+-} 0.005 and there is no evidence of any discrepancy between low-Q{sup 2} and high-Q{sup 2} results. 71 refs., 1 fig., 1 tab.

  15. A new seismic analysis of Alpha Centauri

    E-print Network

    A. Thoul; R. Scuflaire; A. Noels; B. Vatovez; M. Briquet; M. -A. Dupret; J. Montalban

    2003-03-20

    Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (2002) and the data derived from the spectroscopic analysis of Neuforge and Magain (1997). The seismological data obtained by Bouchy and Carrier (2001, 2002) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary.

  16. Fourth High Alpha Conference, volume 1

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The goal of the Fourth High Alpha Conference was to focus on the flight validation of high angle-of-attack technologies and provide an in-depth review of the latest high angle-of-attack activities. Areas that were covered include: high angle-of-attack aerodynamics, propulsion and inlet dynamics, thrust vectoring, control laws and handling qualities, tactical utility, and forebody controls.

  17. Atmospheric Lyman-Alpha Emissions (ALAE)

    NASA Technical Reports Server (NTRS)

    Bertaux, J. L.

    1988-01-01

    The Atmospheric Lyman-Alpha Emissions (ALAE) experiment which is designed to measure atomic hydrogen and deuterium in the terrestrial atmosphere is described. The development of the instrument is a joint effort of the Service d'Aeronomie du CNRS in France and the Institut d'Aeronomie Spatiale in Belgium. This experiment will be part of the atmospheric science research payload flown on the Atmospheric Laboratory for Applications and Science (ATLAS 1) NASA mission planned for late 1990.

  18. Conformational restriction through C alpha i <--> C alpha i cyclization: Ac12c, the largest cycloaliphatic C alpha,alpha- disubstituted glycine known.

    PubMed

    Saviano, M; Iacovino, R; Menchise, V; Benedetti, E; Bonora, G M; Gatos, M; Graci, L; Formaggio, F; Crisma, M; Toniolo, C

    2000-02-01

    Two complete series of N-protected, monodispersed oligopeptide esters to the pentamer level from 1-aminocyclododecane-1-carboxylic acid (Ac(12)c), an alpha-amino acid conformationally constrained through C(alpha)(i) <--> C(alpha)(i) cyclization, and either L-Ala or Aib residues, along with the N-protected Ac(12)c homopeptide alkylamide series from monomer to trimer, have been synthesized by solution methods and fully characterized. The solution-preferred conformations of these peptides have been assessed by Fourier transform ir absorption and (1)H-nmr techniques. Moreover, the molecular structures of one derivative (Z-Ac(12)c-OH) and three peptides [the tripeptide ester Z-L-Ala-Ac(12)c-L-Ala-OMe, the tripeptide alkylamide Z-(Ac(12)c)(3)-NHiPr, and the tetrapeptide ester Z-(Aib)(2)-Ac(12)c-Aib-OtBu (Aib, alpha-aminoisobutyric acid)] have been determined in the crystal state by x-ray diffraction. The results obtained point to the conclusion that beta-bends and 3(10)-helices are preferentially adopted by peptides based on Ac(12)c, the largest cycloaliphatic C-disubstituted glycine known. A comparison with the structural tendencies extracted from published works on peptides from Aib, the prototype of C-disubstituted glycines, and the other extensively studied members of the class of 1-aminocycloalkane-1-carboxylic acids (Ac(n) c, with n = 3-9), is made and the implications for the use of the Ac(12)c residue in the Ac(n) c scan approach of conformationally restricted analogues of bioactive peptides are briefly discussed. PMID:10679624

  19. Fourth High Alpha Conference, volume 2

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The goal of the Fourth High Alpha Conference, held at the NASA Dryden Flight Research Center on July 12-14, 1994, was to focus on the flight validation of high angle of attack technologies and provide an in-depth review of the latest high angle of attack activities. Areas that were covered include high angle of attack aerodynamics, propulsion and inlet dynamics, thrust vectoring, control laws and handling qualities, and tactical utility.

  20. Characterization of the bovine C alpha gene.

    PubMed Central

    Brown, W R; Rabbani, H; Butler, J E; Hammarström, L

    1997-01-01

    The complete genomic sequence of a bovine C alpha gene is reported here. The genomic sequence was obtained from a C alpha phage clone that had been cloned from a genomic EMBL4 phage vector library. The C alpha sequence had previously been expressed as a chimeric antibody and identified as IgA using IgA-specific antibodies. Intron/exon boundaries were determined by comparison of the genomic sequence with an expressed bovine C alpha sequence obtained from spleen by reverse transcription-polymerase chain reaction (RT-PCR). Analysis of 50 Swedish bovine genomic DNA samples using genomic blots and five different restriction enzymes failed to detect evidence of polymorphism. However, PstI digests of Brown Swiss DNA showed a restriction fragment length polymorphism (RFLP), suggesting that at least two allelic variants of bovine IgA exist. Comparison of the deduced amino acid sequence of bovine IgA with sequences available for other species indicated that the highest homology was with that of swine, another artiodactyl. This was the highest homology observed for all mammalian IgA compared except for that between IgA1 and IgA2 in humans. Bovine IgA shares with rabbit IgA3 and IgA4, an additional N-linked glycosylation site at position 282. However, the collective data indicate that cattle are like swine and rodents and unlike rabbits in having a single locus of the gene encoding IgA of this species. Images Figure 4 PMID:9203958

  1. Giant Resonances in the Alpha-Nucleus Interaction

    SciTech Connect

    Karpeshin, F. F.

    2010-04-30

    Tunneling of alpha particles through the Coulomb barrier for the source {sup 135}Pr nucleus is consecutively considered. The effect of sharp peaks arising in the case of coincidence of the alpha energy with that of a quasistationary state within the barrier is elucidated. Peaks' energy depend on the alpha-nucleus potential. They can give rise to 'anomalous' properties of some neutron resonances. The peaks can also be observed in the incoming alpha-nucleus channel. The method can be applied for solution of the reverse problem of the alpha-nucleus scattering.

  2. {alpha}-particle optical potential tests below the Coulomb barrier

    SciTech Connect

    Avrigeanu, M.; Avrigeanu, V.

    2009-02-15

    The results of two recent papers concerning ({alpha},{gamma}) and ({alpha},n) reaction cross sections close to the reaction thresholds are discussed with regard to predictions of a recent {alpha}-particle regional optical potential. It is found that the new measured cross sections are rather well described especially for the dominant reaction channels. Particular features of the {alpha}-particle optical potential at energies below the Coulomb barrier explain the failure of a former regional potential obtained by analysis of {alpha}-particle elastic scattering alone at higher energies. Additional limitations of statistical model calculations for minor reaction channels are also discussed.

  3. Alpha Particle Physics Experiments in the Tokamak Fusion Test Reactor

    SciTech Connect

    Budny, R.V.; Darrow, D.S.; Medley, S.S.; Nazikian, R.; Zweben, S.J.; et al.

    1998-12-14

    Alpha particle physics experiments were done on the Tokamak Fusion Test Reactor (TFTR) during its deuterium-tritium (DT) run from 1993-1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single-particle confinement model in magnetohydrodynamic (MHD) quiescent discharges. Also, the observed alpha particle interactions with sawteeth, toroidal Alfvén eigenmodes (TAE), and ion cyclotron resonant frequency (ICRF) waves were roughly consistent with theoretical modeling. This paper reviews what was learned and identifies what remains to be understood.

  4. Detection of alpha radiation in a beta radiation field

    DOEpatents

    Mohagheghi, Amir H. (Albuquerque, NM); Reese, Robert P. (Edgewood, NM)

    2001-01-01

    An apparatus and method for detecting alpha particles in the presence of high activities of beta particles utilizing an alpha spectrometer. The apparatus of the present invention utilizes a magnetic field applied around the sample in an alpha spectrometer to deflect the beta particles from the sample prior to reaching the detector, thus permitting detection of low concentrations of alpha particles. In the method of the invention, the strength of magnetic field required to adequately deflect the beta particles and permit alpha particle detection is given by an algorithm that controls the field strength as a function of sample beta energy and the distance of the sample to the detector.

  5. {alpha}-condensed state with a core nucleus

    SciTech Connect

    Itagaki, N.; Kimura, M.; Kurokawa, C.; Ito, M.; Oertzen, W. von

    2007-03-15

    We demonstrate based on a microscopic {alpha}-cluster model that {alpha}-condensed states appear not only in light nuclei such as {sup 12}C and {sup 16}O but also in heavier nuclei with a core at excitation energies corresponding to multi-{alpha}-threshold energies. To extend the study of normal {alpha}-condensed state to the cases of heavier nuclei with an inner strongly bound core ({sup 16}O) and also to non-4N-nuclei (e.g., 2{alpha}+dineutron), we introduce a Monte Carlo technique for the description of the Schuck wave function, which are called ''virtual Schuck'' wave function.

  6. ALPHA, Mass Generation and Quantum Information

    NASA Astrophysics Data System (ADS)

    Goradia, Shantilal

    2008-05-01

    The generation of Planck energy 10E19 Gev/Planck time during the observable age of the universe (10E60 Planck times) would generate 10E79 Gev. 10E79 Gev approximates the energy of the baryon number, implying an increase of the baryon number by 10E19/Planck time. What is the source of energy for this mass generation? The ALPHA implicated as negative entropy in [1] must create vacuum energy. Vacuum energy is negative energy. Nature must balance negative energy by generating positive energy (mass), implying ALPHA balances the increasing entropy of the visible universe and generates baryonic mass. Additionally, the successful cloning of the sheep Dolly, and observed molecular blinking dots in biochemistry support the binary BITS of ON and OFF states in [1]. Vindicating Hermite's 1873 mathematical linkage of the base of natural logarithm to transcendentality will implicate natural log based ALPHA in [1] as connected to consciousness. [1] Goradia S: www.arXiv.org/pdf/physics/0210040v3.

  7. Electron Screening and Alpha-Decay

    E-print Network

    Agatino Musumarra

    2010-10-21

    The interplay between nuclear and electromagnetic forces in astrophysical relevant reactions at very low energies is nowadays one of the major subjects of investigation in nuclear astrophysics. Puzzling results concerning the role of Electron Screening (ES) on cross sections of reactions involving light nuclei at low energy open a Pandora pot and many new questions rise on the limits and reliability of the present interpretation of the screening enhancement factor. In the present paper we discuss the simplest physical case where the ES plays an important role in order to have unambiguous determination of ES energy in a clear theoretical scenario. This is the case of alpha-decay of heavy mass nuclei. We deduce the correct sudden and adiabatic limit for such a system including the important relativistic corrections. Then we demonstrate rigorously how in this case the calculation of the sudden and the adiabatic limits leads to the same result. In order to get this result we use the Hellmann-Feynman theorem. After computing the electron screening energy for some systems we discuss the strong modifications of alpha-decay systematic due to electron screening. We conclude proposing a measurement of alpha-decay lifetime of bare nuclei in order to directly deduce ES Energy for heavy nuclei laying in the mass region around 210-240 u.

  8. $\\alpha$ Centauri A in the far infrared

    E-print Network

    Liseau, R; Olofsson, G; Bryden, G; Marshall, J P; Ardila, D; Aran, A Bayo; Danchi, W C; del Burgo, C; Eiroa, C; Ertel, S; Fridlund, M C W; Krivov, A V; Pilbratt, G L; Roberge, A; Thébault, P; Wiegert, J; White, G J

    2012-01-01

    Chromospheres and coronae are common phenomena on solar-type stars. Understanding the energy transfer to these heated atmospheric layers requires direct access to the relevant empirical data. Study of these structures has, by and large, been limited to the Sun thus far. The region of the temperature reversal can be directly observed only in the far infrared and submm. We aim at the determination of the characteristics of the atmosphere in the region of the temperature minimum of the solar sister star alpha Cen A. For the nearby binary system alpha Centauri, stellar parameters are known with high accuracy from measurements. For the basic model parameters Teff, log g and [Fe/H], we interpolate in the grid of GAIA/PHOENIX stellar model atmospheres and compute the corresponding model for the G2 V star alpha Cen A. Comparison with photometric measurements shows excellent agreement between observed photospheric data in the optical and infrared. For longer wavelengths, the modelled spectral energy distribution is co...

  9. Gastric form of alpha chain disease.

    PubMed Central

    Coulbois, J; Galian, P; Galian, A; Couteaux, B; Danon, F; Rambaud, J

    1986-01-01

    A case of alpha chain disease, involving the stomach only, is reported in an Algerian man suffering from epigastric pains. Upper digestive tract fibreoptic endoscopy showed two antral ulcers and an ulcerative gastritis pattern, which promptly disappeared with cimetidine treatment. Antral biopsies at a distance from the ulcers, but not of the ulcer crater itself, disclosed a dense infiltration of antral lamina propria by mature or sometimes atypical plasma cells. On transmural surgical antral biopsy, the infiltrate spread to the superficial part of the submucosa. No other localisation of the disease was found in spite of multiple biopsies obtained by endoscopy, with a peroral capsule and during staging laparotomy. The alpha chain disease protein was absent from serum and urine, but found in the gastric juice and in the cytoplasma of the cellular infiltrate (alpha 1 subclass). A complete clinical, endoscopic, histological and immunological remission was observed after a six months' course of oral tetracycline. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:3087826

  10. Spectrum of mutations in alpha-mannosidosis.

    PubMed Central

    Berg, T; Riise, H M; Hansen, G M; Malm, D; Tranebjaerg, L; Tollersrud, O K; Nilssen, O

    1999-01-01

    alpha-Mannosidosis is an autosomal recessive disorder caused by deficiency of lysosomal alpha-mannosidase (LAMAN). The resulting intracellular accumulation of mannose-containing oligosaccharides leads to mental retardation, hearing impairment, skeletal changes, and immunodeficiency. Recently, we reported the first alpha-mannosidosis-causing mutation affecting two Palestinian siblings. In the present study 21 novel mutations and four polymorphic amino acid positions were identified by the screening of 43 patients, from 39 families, mainly of European origin. Disease-causing mutations were identified in 72% of the alleles and included eight splicing, six missense, and three nonsense mutations, as well as two small insertions and two small deletions. In addition, Southern blot analysis indicated rearrangements in some alleles. Most mutations were private or occurred in two or three families, except for a missense mutation resulting in an R750W substitution. This mutation was found in 13 patients, from different European countries, and accounted for 21% of the disease alleles. Although there were clinical variations among the patients, no significant LAMAN activity could be detected in any of the fibroblast cultures. In addition, no correlation between the types of mutations and the clinical manifestations was evident. PMID:9915946

  11. Utilisation des matériaux luminescents pour la métrologie des faisceaux intenses UVX d'impulsions ultracourtes

    NASA Astrophysics Data System (ADS)

    Fedorov, N.; Nagirnyi, V.; Vasil'Ev, A.; Belsky, A.; Carré, B.; Feldbach, E.; Gaudin, J.; Geoffroy, G.; Guizard, S.; de Grazia, M.; Kirm, M.; Martin, P.; Merdji, H.

    2006-12-01

    Récemment nous avons débuté des séries d'expériences sur l'interaction d'impulsions intenses VUV avec les solides luminescents. Le but principal en est l'étude des mécanismes d'interaction et de transfert d'énergie entre les excitations électroniques dans les solides à large bande interdite. L'application directe de ces études sera le développement de matériaux et de méthodes de métrologie pour les faisceaux UVX intenses. Nous présentons les résultats obtenus pour CdWO{4} qui montrent que ce cristal pourra servir comme un scintillateur pour le rayonnement VUV intense.

  12. Que peut-on voir avec des neutrons? Une introduction pour des non spécialistes

    NASA Astrophysics Data System (ADS)

    Schweizer, J.

    2005-11-01

    Le neutron est une particule élémentaire qui a été découverte en 1932 par James Chadwick. Ses caractéristiques principales sont résumées dans le tableau I. Il a été utilisé pour la première fois par Clifford Shull en 1946 comme outil pour des expériences de diffusion. Cette technique s'est depuis constamment développée pour concerner tous les aspects de la matière condensée: physique, chimie, matériaux, biologie. Il s'agit d'un outil tout à fait exceptionnel car le neutron possède des propriétés uniques et particulièrement adaptées pour ces études.

  13. Les effets du travail en equipe dans l'apprentissage par projets sur la motivation des etudiantes et des etudiants en formation des ingenieurs

    NASA Astrophysics Data System (ADS)

    Fernandez, Nicolas

    Les representants des secteurs industriels et les, milieux professionnels en Amerique du Nord reprochaient aux universites de former des ingenieurs avec peu d'experience pratique en resolution de problemes et en conception. Quelques programmes de genie ont alors mis en place le travail en equipe dans l'apprentissage par projets. Beaucoup d'ecrits font valoir les benefices de l'apprentissage par projets sur la motivation des etudiants. Or, ces benefices commencent a peine a faire l'objet de recherches visant a produire des donnees probantes a ce sujet. Les travaux sur la motivation en contexte d'apprentissage et les modeles theoriques developpes sont issus d'environnements d'apprentissage marques par l'enseignement magistral. Le modele de la valeur attendue de la tache (Eccles et Wigfield, 1995; Neuville, 2004) et le modele du systeme-groupe (St-Arnaud, 2008) ont ete retenus pour mesurer les effets du travail en equipe dans l'apprentissage par projets sur la motivation. La recherche visait aussi a approfondir et a nuancer la comprehension de la motivation des etudiants universitaires apprenant en contexte innovant. Les sujets constituent des etudiants (n=100) travaillant sur des projets d'integration au cours des trois sessions initiales du programme de genie mecanique d'une universite canadienne. L'analyse de regression multiple revele que les construits de la motivation expliquent un tiers de la variance de l'engagement academique dans la realisation du projet d'integration. Les perceptions de l' "expectancy", de la valeur intrinseque et utilitaire sont les determinants principaux de l'engagement des etudiants. L'analyse de variance multivariee a mesures repetees indique que la motivation des etudiants pour le travail sur les projets d'integration a augmente au cours des trois sessions initiales du parcours de formation. Finalement, malgre l'absence d'interaction significative entre les variables de motivation et de l'equipe, les reponses des sujets indiquent une amelioration du travail en equipe au terme des trois sessions. Mots cle: 1. apprentissage par projet; 2. projets d'integration; 3. travail en equipe; 4. motivation; 5. valeur attendue de la tache; 6. expectancy; 7. valeur intrinseque; 8. valeur utilitaire; 9. formation d'ingenieurs; 10. analyse quantitative.

  14. Révision systématique des effets de la fréquence des repas en famille sur les résultats psychosociaux chez les jeunes

    PubMed Central

    Harrison, Megan E.; Norris, Mark L.; Obeid, Nicole; Fu, Maeghan; Weinstangel, Hannah; Sampson, Margaret

    2015-01-01

    Résumé Objectif Effectuer une révision systématique des effets de repas en famille fréquents sur les résultats psychosociaux chez les enfants et les adolescents et examiner s’il existe des différences dans les résultats selon le sexe. Sources des données Des études ont été cernées à la suite d’une recherche dans MEDLINE (de 1948 à la dernière semaine de juin 2011) et dans PsycINFO (de 1806 à la première semaine de juillet 2011) à l’aide de l’interface Ovide. Les expressions et mots clés MeSH utilisés seuls ou en combinaisons étaient les suivants : family, meal, food intake, nutrition, diets, body weight, adolescent attitudes, eating behaviour, feeding behaviour et eating disorders. Les bibliographies des articles jugés pertinents ont aussi été passées en revus. Sélection des études La recherche initiale a produit 1783 articles. Pour être incluses dans l’analyse, les études devaient répondre aux critères suivants : être publiées en anglais dans une revue révisée par des pairs; porter sur des enfants ou des adolescents; traiter de l’influence des repas en famille sur les paramètres psychosociaux (p. ex. consommation de drogues et autres substances, troubles de l’alimentation, dépression) chez les enfants ou les adolescents; avoir une conception d’étude appropriée, notamment des méthodes statistiques acceptables pour l’analyse des paramètres. Quatorze articles satisfaisaient aux critères d’inclusion. Deux examinateurs indépendants ont étudié et analysé les articles. Synthèse Dans l’ensemble, les résultats font valoir que la fréquence des repas en famille est inversement proportionnelle aux troubles de l’alimentation, à la consommation d’alcool et de drogues, aux comportements violents, aux sentiments de dépression ou aux pensées suicidaires chez les adolescents. Il existe une relation positive entre de fréquents repas en famille, une bonne estime de soi et la réussite scolaire. Les études révèlent des différences considérables dans les résultats chez les enfants et adolescents masculins et féminins, les sujets féminins ayant des résultats plus positifs. Conclusion Cette révision systématique vient confirmer davantage qu’il convient de préconiser de fréquents repas en famille. Tous les professionnels de la santé devraient renseigner les familles concernant les bienfaits de prendre régulièrement ensemble des repas.

  15. Nyomárka y Istv án: Rövid hor vát és szerb nyelvtörténet [Kurze Geschichte des Kroatischen und des Serbischen

    E-print Network

    Vig, Istvá n

    2009-01-01

    Mariboru, Filozofska fakulteta, blanka.bosnjak@uni-mb.si NyoMáRKAy ISTVáN: RöviD hORváT és szeRB NyeLvTöR- TéNeT [Kurze Geschichte des Kroatischen und des Serbischen]. Budapest: ELTE Szláv Filológiai Tanszék, 2007. opera Slavica Bu- dapestinensia... Nyomárkay veröffentlichtete schon mehrere Bücher, die als Neuheit in verschiedenen Forschungsbereichen gelten. Auch sein letztes Werk gehört zu dieser Tradition. Es handelt sich um die erste auf Ungarisch verfasste Geschich- te des Kroatischen und des...

  16. Une recension des écrits concernant la réalité psychoaffective des femmes ayant une vulvodynie : Difficultés rencontrées et stratégies développées

    PubMed Central

    Cantin-Drouin, Maude; Damant, Dominique; Turcotte, Daniel

    2008-01-01

    HISTORIQUE : Au cours des trois dernières décennies, une attention grandissante a été portée à l’étude du syndrome de vulvodynie, soit un inconfort vulvaire chronique inexpliqué, éprouvé en l’absence de pathologie précisée. En plus d’avoir des répercussions physiques, l’expérience de la vulvodynie comporte une dimension psychosociale. OBJECTIF : Cet article vise à faire une recension des écrits sur la réalité psychoaffective des femmes qui éprouvent une vulvodynie. MÉTHODE : Une recherche documentaire basée sur une exploration systématique de textes présentant des résultats de recherche et recensés dans les principales banques de données en sciences sociales, dont Dissertation Abstracts, Current Contents et PsycINFO, a été réalisée. RÉSULTATS : Cette recension des écrits révèle, malgré la présence de certains résultats divergents, que les femmes ayant une vulvodynie affrontent souvent des difficultés identitaires et psychologiques, qui sont influencées notamment par les normes sociales de sexualité et de féminité. Pour composer avec ces difficultés, les femmes développent différentes stratégies visant à diminuer le stress occasionné par la douleur et à améliorer leur bien-être psychologique. CONCLUSION : Les difficultés relationnelles et psychologiques vécues par les femmes ayant une vulvodynie ne découlent pas seulement de la douleur physique, mais aussi du sens qu’elles lui accordent, souvent influencé par les discours sociaux sur l’hétérosexualité et la féminité. Il importe donc d’intervenir auprès des femmes en tenant compte de l’influence du contexte social tout en poursuivant le développement des connaissances sur les aspects psychosociaux de cette expérience. PMID:18592063

  17. Functional and Genomic Analyses of Alpha-Solenoid Proteins

    PubMed Central

    Fournier, David; Palidwor, Gareth A.; Shcherbinin, Sergey; Szengel, Angelika; Schaefer, Martin H.; Perez-Iratxeta, Carol; Andrade-Navarro, Miguel A.

    2013-01-01

    Alpha-solenoids are flexible protein structural domains formed by ensembles of alpha-helical repeats (Armadillo and HEAT repeats among others). While homology can be used to detect many of these repeats, some alpha-solenoids have very little sequence homology to proteins of known structure and we expect that many remain undetected. We previously developed a method for detection of alpha-helical repeats based on a neural network trained on a dataset of protein structures. Here we improved the detection algorithm and updated the training dataset using recently solved structures of alpha-solenoids. Unexpectedly, we identified occurrences of alpha-solenoids in solved protein structures that escaped attention, for example within the core of the catalytic subunit of PI3KC. Our results expand the current set of known alpha-solenoids. Application of our tool to the protein universe allowed us to detect their significant enrichment in proteins interacting with many proteins, confirming that alpha-solenoids are generally involved in protein-protein interactions. We then studied the taxonomic distribution of alpha-solenoids to discuss an evolutionary scenario for the emergence of this type of domain, speculating that alpha-solenoids have emerged in multiple taxa in independent events by convergent evolution. We observe a higher rate of alpha-solenoids in eukaryotic genomes and in some prokaryotic families, such as Cyanobacteria and Planctomycetes, which could be associated to increased cellular complexity. The method is available at http://cbdm.mdc-berlin.de/~ard2/. PMID:24278209

  18. On the mechanism of the chemical and enzymic oxygenations of alpha-oxyprotohemin IX to Fe.biliverdin IX alpha.

    PubMed Central

    Sano, S; Sano, T; Morishima, I; Shiro, Y; Maeda, Y

    1986-01-01

    alpha-Oxyprotohemin IX, an early intermediate in heme catabolism, was synthesized and its autoxidation to biliverdin IX alpha was studied. In anaerobic aqueous pyridine, alpha-oxyprotohemin (hexacoordinated) underwent autoreduction to yield an Fe(II) alpha-oxyprotoporphyrin pi-neutral radical bis(pyridine) complex, which reacted with an equimolar amount of dioxygen to give pyridine.verdohemochrome IX alpha and CO in 75-80% yield via an intermediate with an absorption maximum at 893 nm. Verdohemochrome IX alpha did not react with further dioxygen. Reconstituted apomyoglobin.alpha-oxyprotohemin IX complex (pentacoordinated) reacted with an equimolar amount of dioxygen to form an Fe(II) oxyporphyrin pi-neutral radical intermediate, which rearranged to a green compound (lambda max 660 and 704 nm) with elision of CO. The green product, which is probably an apomyoglobin.verdoheme pi-radical complex, reacted with another equimolar amount of dioxygen to give Fe(III).biliverdin IX alpha. Demetallation of this gave biliverdin IX alpha in overall yield of 70-75%. These results indicate that the sequence of oxyheme autoxidation in the presence of apomyoglobin is alpha-oxyprotoheme IX O2----CO----verdohemochrome IX alpha pi-radical O2----Fe(III).biliverdin IX alpha. A similar mechanism may prevail in vivo. The hexa- and pentacoordinated Fe(II) pi-radical form of the oxyporphyrin is crucial in triggering the autoxidation of the complex to verdohemochrome IX alpha. Further oxygenation of verdohemochrome IX alpha to Fe(III).biliverdin IX alpha occurred only in the pentacoordinated apomyoglobin.verdoheme Fe(II) complex. PMID:3456152

  19. Ozone inactivation of human alpha 1-proteinase inhibitor

    SciTech Connect

    Johnson, D.A.

    1980-06-01

    Ozone decreased the trypsin, chymotrypsin, and elastase inhibitory activities of human alpha 1-proteinase inhibitor both in plasma and in solutions of the pure inhibitor. The total loss of porcine elastase inhibitory activity required 18 mol of ozone/mol of pure alpha 1-PI and approximately 850 mol of ozone/mol of alpha 1-PI in plasma. A corresponding loss of the ability to inhibit human leukocyte elastase was observed. Inactivated alpha 1-PI contains four residues of methionine sulfoxide, in addition to oxidized tryosine and tryptophan. Electrophoretic analysis demonstrated that the ozone-inactivated alpha 1-PI did not form normal complexes with serine proteinases. These findings suggest that the inhalation of ozone could inactivate alpha 1-PI on the airspace side of the lung to create a localized alpha 1-PI deficiency, which might contribute to the development of emphysema.

  20. Determination of the alpha(s) using jet rates at LEP

    NASA Astrophysics Data System (ADS)

    Donkers, Michael A.

    Jets are produced in any high energy collision of particles in which quarks are produced in the final state. Using the OPAL detector to measure particles produced in e+e- collisions at the LEP accelerator, the rate of jet formation has been measured at 91 GeV as well as each of the LEP2 energies, ranging from 161 GeV to 207 GeV. The jet rate observables, in particular the differential 2-jet rate and the average jet rate can be used to determine a value of the strong coupling constant, alphas, by fitting to various theoretical predictions. The value of alphas has been determined using data at 91 GeV and a combined sample comprising all of the LEP2 energies with a luminosity weighted centre-of-mass energy of 195.8 GeV for 10 theoretical predictions and two jet clustering algorithms. A fit of the 91 GeV and LEP2 values of alphas determined using the ln R matching prediction is also performed on the D2 and distributions to the 3-loop alphas prediction to produce 4 values of alphas(MZ 0).

  1. The H-alpha Galaxy Survey II. Extinction and NII corrections to H-alpha fluxes

    E-print Network

    P. A. James; N. S. Shane; J. H. Knapen; J. Etherton; S. M. Percival

    2004-10-15

    We study the two main corrections generally applied to narrow-band H-alpha fluxes from galaxies in order to convert them to star formation rates, namely for NII contamination and for extinction internal to the galaxy. From an imaging study using narrow-band filters, we find the NII and H-alpha emission to be differently distributed. In most disk star formation regions the NII fraction is small, whereas some galaxies display a diffuse central component which can be dominated by NII emission. We consider explanations for variations in the NII/H-alpha ratio, including metallicity variations and different excitation mechanisms. We then estimate the extinction towards star formation regions in spiral galaxies, firstly using Br-gamma/H-alpha line ratios. We find that extinction values are larger in galaxy nuclei than in disks, and that there is no evidence for heavily dust-embedded regions emerging in the near-IR. We use optical emission line data from the literature to show only a moderate dependence of extinction on inclination, consistent with broad-band photometric studies; typical extinctions are smaller for late-type dwarfs than for spiral types. Finally, we show that the application of type-dependent extinction corrections significantly improves the agreement between star formation rates from H-alpha and IRAS fluxes. This agreement argues against star formation in normal galaxies being dominated by heavily dust-embedded components.

  2. Synergistic antiproliferative activity of tumor necrosis factor alpha (TNF-alpha) and lovastatin.

    PubMed

    Sora, M K; Kruszewski, A A; Stok?osa, T; Czyzyk, J; Lasek, W; Malejczyk, J; Jakóbisiak, M

    1994-01-01

    We assessed the antiproliferative effect of tumor necrosis factor alpha (TNF-alpha) and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, alone and in combination, on two murine tumor cell lines. Recombinant TNF-alpha inhibited proliferation of murine MmB16 melanoma cells in a concentration-dependent fashion but stimulated growth of murine L1210 leukemia cells at 0.1 ng/ml concentration. Lovastatin inhibited proliferation both of murine MmB16 melanoma cells and of murine L1210 leukemia cells in a concentration-dependent fashion. In combination with tumor necrosis factor alpha lovastatin inhibited synergistically growth of both cell lines as assessed by isobologram analysis. Our data show that lovastatin, a cholesterol synthesis inhibitor, introduced to the clinic to treat hypercholesterolemia, used either as a single or in combination with TNF-alpha inhibits growth of MmB16 melanoma and L1210 leukemia cells. PMID:7487365

  3. Proprietes Adiabatiques des Naines Blanches Pulsantes de Type ZZ Ceti

    NASA Astrophysics Data System (ADS)

    Brassard, Pierre

    1992-01-01

    Cette these a pour but d'etudier les proprietes des oscillation non-radiales des etoiles ZZ Ceti, appelees aussi etoiles DA variables, dans le contexte de la theorie adiabatique des petites oscillations. Ces oscillations sont observables, pour ce type d'etoiles, sous forme de variations periodiques de la luminosite. A partir d'une analyse de modeles stellaires, analyse qui consiste principalement a calculer et a interpreter les periodes d'oscillations des modeles, nous voulons mieux connai tre les proprietes physiques fondamentales des ZZ Ceti. Nous developpons tout d'abord divers outils pour entreprendre cette etude. Apres avoir presente le formalisme mathematique de base decrivant les oscillations non-radiales d'une etoile, nous discutons des difficultes pouvant etre rencontrees dans le calcul de la frequence de Brunt-Vaisala, une quantite fondamentale pour le calcul des periodes d'oscillations. Par la suite, nous developpons un modele theorique simple permettant d'analyser et d'interpreter la structure des periodes calculees (ou observees) en termes des proprietes de structure de l'etoile. Nous presentons aussi les outils numeriques tout a fait originaux utilises pour calculer nos periodes a partir de modeles stellaires. Finalement, nous presentons les resultats d'ensemble de l'analyse de nos modeles, et discutons de l'interpretation des observations de periodes et du taux de variation de ces periodes en termes de structure de l'etoile et de composition du noyau de l'etoile, respectivement. Ces resultats representent l'etude la plus complete a ce jour de la seismologie des naines blanches.

  4. La modelisation mathematique dans l'enseignement de la chimie des gaz a des eleves de la cinquieme annee du secondaire

    NASA Astrophysics Data System (ADS)

    Gauthier, Diane

    Les problemes d'enseignement de la chimie des gaz parfaits sont donc importants. Si plusieurs etudes ont ete realisees dans le but d'identifier et d'interpreter ces problemes, aucune recherche, a notre connaissance, n'a ete realisee sur l'enseignement des lois sur les gaz parfaits. Notre recherche sur l'enseignement est donc pionniere. Elle a pour objectif general de construire et d'analyser une sequence d'enseignement de la chimie des gaz comportant diverses situations de modelisation mathematique des conduites des gaz. Les principaux objectifs specifiques sont les suivants: (1) identifier et caracteriser les situations qui provoquent une evolution des conceptions naives des eleves, evolution vers des connaissances plus adequate sur les gaz; (2) identifier et caractEriser les situations qui provoquent une evolution des connaissances mathematiques des eleves leur permettant d'interpreter convenablement les resultats des experiences, d'eprouver leurs conceptions, de donner un sens aux notions et aux relations impliquees dans les lois des gaz parfaits, lois de Boyle-Mariotte et Gay-Lussac. Une sequence d'enseignement comportant huit situations est d'eleves de secondaire V. La construction de ces situations est orientee par les recherches sur les conceptions naives des eleves, par les etudes sur l'evolution historique des conceptions sur les gaz et des pratiques scientifiques, ainsi que par les etudes theoriques et empiriques realisees en didactique des sciences et des mathematiques. La methodologie de l'ingenierie didactique (Artigue, 1998) qui constitue une application de la theorie des situations didactiques (Brousseau, 1986) est utilisee dans la construction et l'analyse des situations d'enseignement. Une analyse a priori de chacune des situations d'enseignement est effectuee; elle a pour but dexpliquer les choix des taches qui font partie des situations et de preciser la gestion didactique des situations. Diverses situations d'enseignement de la chimie ont ainsi ete construites. L'analyse a posteriori des situations, analyse des interactions didactiques lors du deroulement en classe de ces situations, est confrontee a l'analyse a priori realisee lors de la construction de ces situations. La pertinence de ces situations est ainsi examinee, en regard des objectifs de la recherche. (Abstract shortened by UMI.)

  5. Producing a compound Nucleus via Inelastic Scattering: The 90Zr(alpha,alpha')90Zr* Case

    SciTech Connect

    Escher, J E; Dietrich, F S

    2008-05-23

    In a Surrogate reaction a compound nucleus is produced via a direct reaction (pickup, stripping, or inelastic scattering). For a proper application of the Surrogate approach it is necessary to predict the resulting angular momentum and parity distribution in the compound nucleus. A model for determining these distributions is developed for the case of inelastic alpha scattering off a spherical nucleus. The focus is on obtaining a first, simple description of the direct-reaction process that produces the compound nucleus and on providing the basis for a more complete treatment of the problem. The approximations employed in the present description are discussed and the extensions required for a more rigorous treatment of the problem are outlined. To illustrate the formalism, an application to {sup 90}Zr({alpha},{alpha}{prime}){sup 90}Zr* is presented.

  6. Ly-alpha and H-alpha emission by superthermal proton beams. [in solar flares

    NASA Technical Reports Server (NTRS)

    Canfield, R. C.; Chang, C.-R.

    1985-01-01

    Simnett and Harrison (1984) have presented a model in which 100-1000 keV protons are an energy transfer agent linking coronal mass ejections and solar flares. Orrall and Zirker (1976) suggested that such protons, incident upon the chromosphere, would produce nonthermal Ly-alpha emission after charge exchange with ambient chromospheric hydrogen atoms. The present investigation is concerned with a study of the charge-exchange mechanism proposed by Orral and Zirker. The physical theory of the formation of nonthermal Ly-alpha (and H-alpha) emission is considered, taking into account photon emission, atomic transitions, atomic equilibrium, the dominant atomic processes, and the stopping of superthermal protons. Computational results presented by Orrall and Zirker are extended.

  7. Inflammation inhibiting properties of rat alphaM foetoprotein (rat-alpha2 macroglobulin), an acute phase reactant.

    PubMed

    van Gool, J; Ladiges, N C; de Nie, I; Boers, W

    1977-01-01

    alphaMFoetoprotein of the rat (rat alpha2macroglobulin) is present in serum during foetal development. After birth, alphaMFP declines rapidly, but the protein returns after injury. The injury we used consisted of skin and muscle incision, laparotomy, BaSO4 i.p. The protein occurs also during liverregeneration, livercardinogenesis en during infections. Therefore, alphaMFP can be considered as an acute phase reactant. We found that this protein strongly inhibits inflammatory exudation caused by carrageenin, histamin, prostaglandin E2, 5HT and bradykinin. Furthermore, we found that alphaMFP suppresses completely inflammatory reactions during Ga1.N-hepatitis. In this condition, the primary biochemical lesion, consisting of liver UDPG depletion, does occur in spite of the protective effect of alphaMFP. Thus, the inflammatory inhibiting effects of alphaMFP seem to be an important mechanism reducing inflammatory reaction patterns. PMID:75682

  8. The 106Cd(alpha,alpha)106Cd elastic scattering in a wide energy range for gamma-process studies

    E-print Network

    A. Ornelas; G. G. Kiss; P. Mohr; D. Galaviz; Zs. Fülöp; Gy. Gyürky; Z. Máté; T. Rauscher; E. Somorjai; K. Sonnabend; A. Zilges

    2015-04-29

    Alpha elastic scattering angular distributions of the 106Cd(alpha,alpha)106Cd reaction were measured at three energies around the Coulomb barrier to provide a sensitive test for the alpha + nucleus optical potential parameter sets. Furthermore, the new high precision angular distributions, together with the data available from the literature were used to study the energy dependence of the locally optimized {\\alpha}+nucleus optical potential in a wide energy region ranging from E_Lab = 27.0 MeV down to 16.1 MeV. The potentials under study are a basic prerequisite for the prediction of alpha-induced reaction cross sections and thus, for the calculation of stellar reaction rates used for the astrophysical gamma process. Therefore, statistical model predictions using as input the optical potentials discussed in the present work are compared to the available 106Cd + alpha cross section data.

  9. Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.

    PubMed Central

    Donella-Deana, A; Cesaro, L; Sarno, S; Brunati, A M; Ruzzene, M; Pinna, L A

    2001-01-01

    CK2 is a pleiotropic and constitutively active serine/threonine protein kinase composed of two catalytic (alpha and/or alpha') and two regulatory beta-subunits, whose mechanism of modulation is still obscure. Here we show that CK2 alpha/alpha' subunits undergo intermolecular (trans) tyrosine-autophosphorylation, which is dependent on intrinsic catalytic activity and is suppressed by the individual mutation of Tyr182, a crucial residue of the activation loop, to phenylalanine. At variance with serine-autophosphorylation, tyrosine-autophosphorylation of CK2alpha is reversed by ADP and GDP and is counteracted by the beta-subunit and by a peptide reproducing the activation loop of CK2alpha/alpha' (amino acids 175-201). These results disclose new perspectives about the mode of regulation of CK2 catalytic subunits. PMID:11439109

  10. Expression of alpha/beta interferons (IFN-alpha/beta) and their relationship to IFN-alpha/beta-induced genes in lymphocytic choriomeningitis.

    PubMed Central

    Sandberg, K; Eloranta, M L; Campbell, I L

    1994-01-01

    Expression of alpha interferon (IFN-alpha)-, IFN-beta-, and IFN-alpha/beta-induced genes was monitored during the development of lymphocytic choriomeningitis (LCM) to assess whether a restricted influence of these antiviral cytokines could be found in the central nervous system (CNS). High levels of IFN-alpha (83 +/- 42 U/ml) were present in the blood of LCM virus-infected mice 3 days postinfection, whereas IFN-beta was not detected (< 1.0 U/ml) at any time point. Spleens contained high levels of IFN-alpha and IFN-beta mRNAs at days 1 and 3 postinfection, whereas no IFN-alpha mRNA and only low levels of IFN-beta mRNA were detected in brains. In situ hybridization showed IFN-alpha mRNA-expressing cells in the marginal zones of the spleen and in the subcapsular sinus and outer cortex of cervical lymph nodes. The expression of 2',5'-oligoadenylate synthetase (2',5'-OAS) mRNA followed the expression of IFN-beta mRNA in the brain, whereas 2',5'-OAS mRNA in the periphery was associated with systemic IFN-alpha. The localization of IFN-alpha-expressing cells in the spleen and lymph nodes in proximity to T- and B-cell compartments is consistent with a role for these cytokines in immune regulation. Furthermore, the absence of IFN-alpha and the relatively low level and delayed expression of IFN-beta in the brain suggest that the CNS is an especially vulnerable organ for virus replication. With certain strains of LCM virus, the absence of early antiviral IFN-alpha/beta activity and preferential virus growth in the brain might lead to targeted T-cell inflammation of the CNS, resulting in death of the animal. Images PMID:7933119

  11. Prévalence des cervicalgies et douleurs des membres supérieures chez les utilisateurs d'ordinateur en milieu professionnel à Casablanca (Maroc)

    PubMed Central

    Seknaji, Nawal; Rachidi, Wafaa; Hassoune, Samira; Janani, Saadia; Nani, Samira; Maaroufi, Abderrahmane; Mkinsi, Ouafaa

    2013-01-01

    Introduction Les cervicalgies et douleurs du membre supérieur (CDMS) affectent des millions d'utilisateurs d'ordinateurs dans les pays développés. L'objectif de ce travail était de déterminer la prévalence des cervicalgies et douleurs du membre supérieur (CDMS) à Casablanca et identifier les différents facteurs de risque qui y sont impliqués, afin de définir les sous-groupes à haut risque, et d’établir des plans d'intervention efficaces. Méthodes Il s'agit d'une étude transversale, menée chez 118 employés de bureau francophones et utilisant l'ordinateur, à Casablanca. Les données ont été collectées de Décembre 2011 à Juin 2012, en utilisant la version française d'un questionnaire validé: Maastricht-Upper-extremity-Questionnaire. Résultats 118 utilisateurs d'ordinateur en milieu professionnel ont été recrutés. Parmi les employés enquêtés, 93% ont rapporté des CDMS localisées au moins à un site. Les plaintes les plus fréquemment rapportées étaient les douleurs des épaules et les cervicalgies (48,3% et 46,6% respectivement). Nous n'avons pas remarqué de différence significative des fréquences des douleurs selon le genre. Nos résultats concordent avec les données de la littérature où il existe un certain consensus quant à l'impact des mauvaises conditions ergonomiques sur les troubles musculo-squelettiques du membre supérieur en milieu professionnel. De même, les études récentes examinant les effets combinés et/ou interactifs tant des facteurs biomécaniques/physiques que de facteurs psychosociaux professionnels vont de pair avec nos résultats. Conclusion Il en ressort que les stratégies d'intervention visant à réduire les CDMS doivent agir essentiellement sur 3 volets, le premier correspond à l'amélioration et la sensibilisation quant au respect des conditions ergonomiques, le second concerne l'amélioration des conditions psychosociales. Enfin le troisième volet vise la rationalisant de la demande de travail. PMID:23785562

  12. On the Relative Stability of Singly Protonated des-Arg1 and des-Arg9 Bradykinins.

    SciTech Connect

    Laskin, Julia; Bailey, Thomas; Denisov, Eduard V.; Futrell, Jean H.

    2002-10-17

    Normal-incidence surface-induced dissociation of singly protonated des-Arg1-bradykinin (PPGFSPFR) and des-Arg9-bradykinin (RPPGFSPF) has been studied using a specially designed Fourier Transform Ion Cyclotron Resonance mass spectrometer (FT-ICR MS). We found that with a reaction time of 1 s the collision energy-resolved fragmentation efficiency curve (FEC) for des-Arg9-bradykinin is shifted to lower energies by about 4 eV relative to the FEC for des-Arg1-bradykinin. Because the Arrhenius activation energies found by Williams and co-workers in BIRD experiments are 0.82 eV and 1.2 eV for des-Arg1 and des-Arg9 bradykinin, respectively, we expected to find the reverse order in our long reaction time FTICR-SID experiments. We rationalize the difference between our data and the thermal kinetics using Tolman's theorem to calculate threshold energies from the Arrhenius activation parameters. The threshold energies are 1.15 eV and 1.24 eV for des-Arg1 and des-Arg9 bradykinin, respectively. How ever, des-Arg1-bradykinin dissociates via a very tight transition state. Consequently, microcanonical rate-energy dependencies for these two peptides cross at low internal energies. Rate constants of 1 s-1 are reached at internal energies of 7.9 eV for des-Arg1-bradykinin and 6.9 eV for des-Arg9 bradykinin, in excellent agreement with the energy shift in our FECs.

  13. Far-Infrared and Millimeter Continuum Studies of K-Giants: Alpha Boo and Alpha Tau

    NASA Technical Reports Server (NTRS)

    Cohen, Martin; Carbon, Duane F.; Welch, William J.; Lim, Tanya; Forster, James R.; Goorvitch, David; Thigpen, William (Technical Monitor)

    2002-01-01

    We have imaged two normal, non-coronal, infrared-bright K-giants, alpha Boo and alpha Tau, in the 1.4-millimeter and 2.8-millimeter continuum using BIMA. These stars have been used as important absolute calibrators for several infrared satellites. Our goals are: (1) to probe the structure of their upper photospheres; (2) to establish whether these stars radiate as simple photospheres or possess long-wavelength chromospheres; and (3) to make a connection between millimeter-wave and far-infrared absolute flux calibrations. To accomplish these goals we also present ISO Long Wavelength Spectrometer (LWS) measurements of both these K-giants. The far-infrared and millimeter continuum radiation is produced in the vicinity of the temperature minimum in a Boo and a Tau, offering a direct test of the model photospheres and chromospheres for these two cool giants. We find that current photospheric models predict fluxes in reasonable agreement with those observed for those wavelengths which sample the upper photosphere, namely less than or equal to 170 micrometers in alpha Tau and less than or equal to 125 micrometers in alpha Boo. It is possible that alpha Tau is still radiative as far as 0.9 - 1.4 millimeters. We detect chromospheric radiation from both stars by 2.8 millimeters (by 1.4 millimeters in alpha Boo), and are able to establish useful bounds on the location of the temperature minimum. An attempt to interpret the chromospheric fluxes using the two-component "bifurcation model" proposed by Wiedemann et al. (1994) appears to lead to a significant contradiction.

  14. Les neuropeptides gastro-intestinaux cibles des effets des rayonnements ionisants : altérations fonctionnelles

    NASA Astrophysics Data System (ADS)

    Linard, C.; Esposito, V.; Wysocki, J.; Griffiths, N. M.

    1998-04-01

    The symptoms associated with exposure to ionizing radiation are nausea, vomiting, diarrhoea. The response of the gut is complex involving modifications of motility and fluid and electrolyte transport. Gastrointestinal regulatory peptides have an important role in these functions. This study showed that radiation-induced tissue variations of neuropeptides have some repercussions on intestinal biological activity of these peptides soon after irradiation. In addition such modifications are also seen a few years after irradiation. Les symptômes associés à l'exposition aux rayonnements ionisants sont des nausées, vomissements et diarrhées. La réponse du système digestif est complexe, impliquant des modifications de la motilité et du transport d'eau et d'électrolytes. les neuropeptides gastro-intestinaux ont un rôle important dans ces fonctions. Cette étude montre que les variations tissulaires de ces neuropeptides induites par l'irradiation ont des répercussions sur l'activité biologique intestinale pour des temps précoces mais que ces perturbations sont encore visibles quelques années après l'irradiation.

  15. Le Caf des Sciences de l'cole des Ponts ParisTech

    E-print Network

    Ghorbel, Amin

    successivement directeur du Centre d'Etudes Prospectives et d'Informations Internationales (CEPII), conseiller auprès du Ministre de l'Economie, des Finances et de l'Industrie, président du conseil d global currency ? (avec Adam S. Posen, 2009). Il est également l'auteur de plusieurs rapports : Politique

  16. Habilitation Diriger des Recherches en Informatique Ingnierie des profils d'apprenants

    E-print Network

    Jean-Daubias, Stéphanie

    Professeur des Universités émérite, Université Henri Poincaré Nancy 1, France (rapporteur) Alain Mille, avant qu'elle ne devienne mon amie, à l'origine de ma venue à Lyon. Enfin, Alain Mille qui m'a donné, chronologiquement Sandra Nogry, Carole Eyssautier, Marie Lefevre, Blandine Ginon. Avec une mention très spéciale

  17. [TALAF-O.2] Projet des corpus crits des langues manding : le bambara, le maninka1

    E-print Network

    'utilisation expérimentale du CBR dans l'enseignement universitaire du bambara et dans les études linguistiques a montré son accumulated in the framework of this project can be relatively easily extended to other Manding varieties. Je traiterai surtout des aspects linguistiques de notre travail (les détails techniques seront

  18. Vers des boites quantiques a base de graphene

    NASA Astrophysics Data System (ADS)

    Branchaud, Simon

    Le graphene est un materiau a base de carbone qui est etudie largement depuis 2004. De tres nombreux articles ont ete publies tant sur les proprietes electroniques, qu'optiques ou mecaniques de ce materiel. Cet ouvrage porte sur l'etude des fluctuations de conductance dans le graphene, et sur la fabrication et la caracterisation de nanostructures gravees dans des feuilles de ce cristal 2D. Des mesures de magnetoresistance a basse temperature ont ete faites pres du point de neutralite de charge (PNC) ainsi qu'a haute densite electronique. On trouve deux origines aux fluctuations de conductance pres du PNC, soit des oscillations mesoscopiques provenant de l'interference quantique, et des fluctuations dites Hall quantique apparaissant a plus haut champ (>0.5T), semblant suivre les facteurs de remplissage associes aux monocouches de graphene. Ces dernieres fluctuations sont attribuees a la charge d'etats localises, et revelent un precurseur a l'effet Hall quantique, qui lui, ne se manifeste pas avant 2T. On arrive a extraire les parametres caracterisant l'echantillon a partir de ces donnees. A la fin de cet ouvrage, on effectue des mesures de transport dans des constrictions et ilots de graphene, ou des boites quantiques sont formees. A partir de ces mesures, on extrait les parametres importants de ces boites quantiques, comme leur taille et leur energie de charge.

  19. www.iutbayonne.univ-pau.fr DES ENTREPRISES ET

    E-print Network

    Greff, Isabelle

    gestion, analyste financier). · OPTION GMO (Gestion et Management des Organisations) : adjoint au : GCF OU GMO Séminaire de rentrée Initiation à la gestion Tutorat Stage de 3 semaines Approfondissement'ouverture UE2 - Mise en situation professionnelle OPTION GMO UE1 - Management des organisations Langues

  20. Vice-dcanat la recherche Rpertoire des projets

    E-print Network

    Laval, Université

    'agriculture, des pêcheries et de l'alimentation - 2008-05-08 au 2010-06-30 Réf. 91082 Chercheur(s) participant(s) # projet Montant Ministère de l'agriculture, des pêcheries et de l'alimentation GQ091082 DC 43 530