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Sample records for desy wissenschaftlicher jahresbericht

  1. Graphics at DESY

    NASA Astrophysics Data System (ADS)

    Schilling, Peter K.

    1989-12-01

    After a short history of computer graphics at DESY the introduction of graphic workstations based on true and "quasi" standards is described. An overview of graphics hardware and software at DESY is given as well as the communication facilities used. Some remarks about current and future development finish the paper.

  2. The DESY Grid Centre

    NASA Astrophysics Data System (ADS)

    Haupt, A.; Gellrich, A.; Kemp, Y.; Leffhalm, K.; Ozerov, D.; Wegner, P.

    2012-12-01

    DESY is one of the world-wide leading centers for research with particle accelerators, synchrotron light and astroparticles. DESY participates in LHC as a Tier-2 center, supports on-going analyzes of HERA data, is a leading partner for ILC, and runs the National Analysis Facility (NAF) for LHC and ILC in the framework of the Helmholtz Alliance, Physics at the Terascale. For the research with synchrotron light major new facilities are operated and built (FLASH, PETRA-III, and XFEL). DESY furthermore acts as Data-Tier1 centre for the Neutrino detector IceCube. Established within the EGI-project DESY operates a grid infrastructure which supports a number of virtual Organizations (VO), incl. ATLAS, CMS, and LHCb. Furthermore, DESY hosts some of HEP and non-HEP VOs, such as the HERA experiments and ILC as well as photon science communities. The support of the new astroparticle physics VOs IceCube and CTA is currently set up. As the global structure of the grid offers huge resources which are perfect for batch-like computing, DESY has set up the National Analysis Facility (NAF) which complements the grid to allow German HEP users for efficient data analysis. The grid infrastructure and the NAF use the same physics data which is distributed via the grid. We call the conjunction of grid and NAF the DESY Grid Centre. In the contribution to CHEP2012 we will in depth discuss the conceptional and operational aspects of our multi-VO and multi-community Grid Centre and present the system setup. We will in particular focus on the interplay of Grid and NAF and present experiences of the operations.

  3. Centrally managed tapes at DESY

    SciTech Connect

    Hell, O.

    1994-12-31

    Tapes at DESY are managed by the computer center and thus offer virtually unlimited storage space to the DESY computer center users. This paper describes the most recent version of the DESY tape management system, its predecessors having been in service for many years.

  4. Detector developments at DESY.

    PubMed

    Wunderer, Cornelia B; Allahgholi, Aschkan; Bayer, Matthias; Bianco, Laura; Correa, Jonathan; Delfs, Annette; Göttlicher, Peter; Hirsemann, Helmut; Jack, Stefanie; Klyuev, Alexander; Lange, Sabine; Marras, Alessandro; Niemann, Magdalena; Pithan, Florian; Reza, Salim; Sheviakov, Igor; Smoljanin, Sergej; Tennert, Maximilian; Trunk, Ulrich; Xia, Qingqing; Zhang, Jiaguo; Zimmer, Manfred; Das, Dipayan; Guerrini, Nicola; Marsh, Ben; Sedgwick, Iain; Turchetta, Renato; Cautero, Giuseppe; Giuressi, Dario; Menk, Ralf; Khromova, Anastasiya; Pinaroli, Giovanni; Stebel, Luigi; Marchal, Julien; Pedersen, Ulrik; Rees, Nick; Steadman, Paul; Sussmuth, Mark; Tartoni, Nicola; Yousef, Hazem; Hyun, HyoJung; Kim, KyungSook; Rah, Seungyu; Dinapoli, Roberto; Greiffenberg, Dominic; Mezza, Davide; Mozzanica, Aldo; Schmitt, Bernd; Shi, Xintian; Krueger, Hans; Klanner, Robert; Schwandt, Joem; Graafsma, Heinz

    2016-01-01

    With the increased brilliance of state-of-the-art synchrotron radiation sources and the advent of free-electron lasers (FELs) enabling revolutionary science with EUV to X-ray photons comes an urgent need for suitable photon imaging detectors. Requirements include high frame rates, very large dynamic range, single-photon sensitivity with low probability of false positives and (multi)-megapixels. At DESY, one ongoing development project - in collaboration with RAL/STFC, Elettra Sincrotrone Trieste, Diamond, and Pohang Accelerator Laboratory - is the CMOS-based soft X-ray imager PERCIVAL. PERCIVAL is a monolithic active-pixel sensor back-thinned to access its primary energy range of 250 eV to 1 keV with target efficiencies above 90%. According to preliminary specifications, the roughly 10 cm × 10 cm, 3.5k × 3.7k monolithic sensor will operate at frame rates up to 120 Hz (commensurate with most FELs) and use multiple gains within 27 µm pixels to measure 1 to ∼100000 (500 eV) simultaneously arriving photons. DESY is also leading the development of the AGIPD, a high-speed detector based on hybrid pixel technology intended for use at the European XFEL. This system is being developed in collaboration with PSI, University of Hamburg, and University of Bonn. The AGIPD allows single-pulse imaging at 4.5 MHz frame rate into a 352-frame buffer, with a dynamic range allowing single-photon detection and detection of more than 10000 photons at 12.4 keV in the same image. Modules of 65k pixels each are configured to make up (multi)megapixel cameras. This review describes the AGIPD and the PERCIVAL concepts and systems, including some recent results and a summary of their current status. It also gives a short overview over other FEL-relevant developments where the Photon Science Detector Group at DESY is involved. PMID:26698052

  5. The FLASHForward facility at DESY

    NASA Astrophysics Data System (ADS)

    Aschikhin, A.; Behrens, C.; Bohlen, S.; Dale, J.; Delbos, N.; di Lucchio, L.; Elsen, E.; Erbe, J.-H.; Felber, M.; Foster, B.; Goldberg, L.; Grebenyuk, J.; Gruse, J.-N.; Hidding, B.; Hu, Zhanghu; Karstensen, S.; Knetsch, A.; Kononenko, O.; Libov, V.; Ludwig, K.; Maier, A. R.; Martinez de la Ossa, A.; Mehrling, T.; Palmer, C. A. J.; Pannek, F.; Schaper, L.; Schlarb, H.; Schmidt, B.; Schreiber, S.; Schwinkendorf, J.-P.; Steel, H.; Streeter, M.; Tauscher, G.; Wacker, V.; Weichert, S.; Wunderlich, S.; Zemella, J.; Osterhoff, J.

    2016-01-01

    The FLASHForward project at DESY is a pioneering plasma-wakefield acceleration experiment that aims to produce, in a few centimetres of ionised hydrogen, beams with energy of order GeV that are of quality sufficient to be used in a free-electron laser. The plasma is created by ionising a gas in a gas cell with a multi-TW laser system. The plasma wave will be driven by high-current-density electron beams from the FLASH linear accelerator. The laser system can also be used to provide optical diagnostics of the plasma and electron beams due to the <30 fs synchronisation between the laser and the driving electron beam. The project will explore both external and internal witness-beam injection techniques. The operation parameters of the experiment are discussed, as well as the scientific programme.

  6. Salt Tolerance of Desorption Electrospray Ionization (DESI)

    SciTech Connect

    Jackson, Ayanna U.; Talaty, Nari; Cooks, R G; Van Berkel, Gary J

    2007-01-01

    Suppression of ion intensity in the presence of high salt matrices is common in most mass spectrometry ionization techniques. Desorption electrospray ionization (DESI) is an ionization method that exhibits salt tolerance, and this is investigated. DESI analysis was performed on three different drug mixtures in the presence of 0, 0.2, 2, 5, 10, and 20% NaCl:KCl weight by volume from seven different surfaces. At physiological concentrations individual drugs in each mixture were observed with each surface. Collision-induced dissociation (CID) was used to provide additional confirmation for select compounds. Multiple stage experiments, to MS5, were performed for select compounds. Even in the absence of added salt, the benzodiazepine containing mixture yielded sodium and potassium adducts of carbamazepine which masked the ions of interest. These adducts were eliminated by adding 0.1% 7M ammonium acetate to the standard methanol:water (1:1) spray solvent. Comparison of the salt tolerance of DESI with that of electrospray ionization (ESI) demonstrated much better signal/noise characteristics for DESI in this study. The salt tolerance of DESI was also studied by performing limit of detection and dynamic range experiments. Even at a salt concentration significantly above physiological concentrations, select surfaces were effective in providing spectra that allowed the ready identification of the compounds of interest. The already high salt tolerance of DESI can be optimized further by appropriate choices of surface and spray solution.

  7. The DESI Wide Field Corrector Optics

    SciTech Connect

    Doel, Peter; Sholl, Michael J.; Liang, Ming; Brooks, David; Flaugher, Brenna; Gutierrez, Gaston; Kent, Stephen; Lampton, Michael; Miller, Timothy; Sprayberry, David

    2014-01-01

    The Dark Energy Spectroscopic instrument (DESI) is a 5000 fiber multi-object spectrometer system under development for installation on the National Optical Astronomy Observatory (NOAO) Kitt Peak 4m telescope (the Mayall telescope). DESI is designed to perform a 14,000˚ (square) galaxy and Quasi-Stellar Object (QSO) redshift survey to improve estimates of the dark energy equation of state. The survey design imposes numerous constraints on a prime focus corrector design, including field of view, geometrical blur, stability, fiber injection efficiency, zenith angle, mass and cost. The DESI baseline wide-field optical design described herein provides a 3.2˚ diameter field of view with six 0.8- 1.14m diameter lenses and an integral atmospheric dispersion compensator.

  8. Cyber-Physical Systems - Wissenschaftliche Herausforderungen Bei Der Entwicklung

    NASA Astrophysics Data System (ADS)

    Broy, Manfred

    Cyber-Physical Systems adressieren die enge Verbindung eingebetteter Systeme zur Überwachung und Steuerung physikalischer Vorgänge mittels Sensoren und Aktuatoren über Kommunikationseinrichtungen mit den globalen digitalen Netzen (dem Cyberspace"). Dieser Typus von Systemen ermöglicht über Wirkketten eine Verbindung zwischen Vorgängen der physischen Realität und den heute verfügbaren digitalen Netzinfrastrukturen. Dies erlaubt vielfältige Applikationen mit hohem wirtschaftlichen Potential, und mit starker Innovationskraft. Die vollständige Ausschöpfung des Potentials erfordert aber gezielte wissenschaftliche Anstrengungen bei der Entwicklung solcher Systeme im Hinblick auf Methodik, Technologie, Kostenbeherrschung und funktionale Angemessenheit.

  9. Large Grain Superconducting RF Cavities at DESY

    SciTech Connect

    Singer, W.; Brinkmann, A.; Ermakov, A.; Iversen, J.; Kreps, G.; Matheisen, A.; Proch, D.; Reschke, D.; Singer, X.; Spiwek, M.; Wen, H.; Brokmeier, H. G.

    2007-08-09

    The DESY R and D program on cavities fabricated from large grain niobium explores the potential of this material for the production of approx. 1000 nine-cell cavities for the European XFEL. The program investigates basic material properties, comparing large grain material to standard sheet niobium, as well as fabrication and preparation aspects. Several single-cell cavities of TESLA shape have been fabricated from large grain niobium. A gradient up to 41 MV/m at Q0 = 1.4{center_dot}1010 (TB = 2K) was measured after electropolishing. The first three large grain nine-cell cavities worldwide have been produced under contract of DESY with ACCEL Instruments Co. The first tests have shown that all three cavities reach an accelerating gradient up to 30 MV/m after BCP (Buffered Chemical Polishing) treatment, what exceeds the XFEL requirements for RF test in the vertical cryostat.

  10. The NAF: National analysis facility at DESY

    NASA Astrophysics Data System (ADS)

    Haupt, Andreas; Kemp, Yves

    2010-04-01

    Within the framework of a broad collaboration among German particle physicists, the strategic Helmholtz Alliance "Physics a the Terascale", an analysis facility has been set up at DESY. The facility is intended to provide the best possible analysis infrastructure for researches of the ATLAS, CMS, LHCb and ILC experiments and also for theory researchers. In a first part of the contribution, we will present the concept of the NAF and its place in the existing distributed grid landscape of the experiments. In a second part, the building blocks of the NAF will be detailed with an emphasis on technical implementations of some parts: - Usage of VOMS for separating grid resources between collaboration-wide and NAF-specific resources. - interactive and batch cluster and integration with PROOF. - usage of grid proxies to access work group servers and AFS. - the usage and operation of Lustre for fast data access. A special focus is the seamless integration of the facility into the two geographically separated DESY sites and its implications. In a third part, the experience of running the facility for one year will be reported.

  11. Hydroforming of Tesla Cavities at Desy

    SciTech Connect

    W. Singer; H. Kaiser; X. Singer; I. Gonin; I. Zhelezov; T. Khabibullin; P. Kneisel; K. Saito

    2000-07-01

    Since several years the development of seamless niobium cavity fabrication by hydro forming is being pursued at DESY. This technique offers the possibility of lower cost of fabrication and perhaps better rf performance of the cavities because of the elimination of electron-beam welds, which in the standard fabrication technique have sometimes lead to inferior cavity performance due to defects. Several single cell 1300 MHz cavities have been formed from high purity seamless niobium tubes, which are under computer control expanded with internal pressure while simultaneously being swaged axially. The seamless tubes have been made by either back extrusion and flow forming or by spinning or deep drawing. Standard surface treatment techniques such as high temperature post purification, buffered chemical polishing (BCP), electropolishing (EP) and high pressure ultra pure water rinsing (HPR) have been applied to these cavities. The cavities exhibited high Q - values of 2 x 10{sup 10} at 2K and residual resistances as low as 3 n{Omega} after the removal of a surface layer of app. 100 {micro}m by BCP. Surprisingly, even at high gradients up to the maximum measured values of E{sub acc} {approx} 33 MV/m the Q-value did not decrease in the absence of field emission as often observed. After electropolishing of additional 100 {micro}m one of the cavities reached an accelerating gradient of E{sub acc} {ge} 42 MV/m.

  12. The Dark Energy Spectroscopic Instrument (DESI): The NOAO DECam Legacy Imaging Survey and DESI Target Selection

    NASA Astrophysics Data System (ADS)

    Schlegel, David J.; Blum, Robert D.; Castander, Francisco Javier; Dey, Arjun; Finkbeiner, Douglas P.; Foucaud, Sebastien; Honscheid, Klaus; James, David; Lang, Dustin; Levi, Michael; Moustakas, John; Myers, Adam D.; Newman, Jeffrey; Nord, Brian; Nugent, Peter E.; Patej, Anna; Reil, Kevin; Rudnick, Gregory; Rykoff, Eli S.; Ford Schlafly, Eddie; Stark, Casey; Valdes, Francisco; Walker, Alistair R.; Weaver, Benjamin; DECam Legacy Survey Collaboration

    2015-01-01

    The DECam Legacy Survey will conduct a 3-band imaging survey of the Sloan Digital Sky Survey (SDSS) extragalactic footprint. The Dark Energy Camera (DECam) will be used to image the 6700 square degree footprint overlapping SDSS in the region -20 < Dec < +30 deg, to depths of g=24.7, r=23.9, z=23.0. The survey will be conducted from Fall 2014 through Spring 2017, with periodic data releases beginning in March 2015. These releases will include catalogs constructed with the Tractor-based multi-wavelength forced photometry applied to the DECam and WISE satellite data.The Dark Energy Spectroscopic Instrument (DESI) will observe 24 million galaxies and quasars in a 14,000 square degree extragalactic footprint. The targeting in that footprint will be provided by a combination of these DECam data, the MOSAIC camera on the Mayall 4-meter, and the 90Prime camera on the Bok Telescope.

  13. Coupling of Ultrafast LC with Mass Spectrometry by DESI

    NASA Astrophysics Data System (ADS)

    Cai, Yi; Liu, Yong; Helmy, Roy; Chen, Hao

    2014-10-01

    Recently we reported a desorption electrospray ionization (DESI) interface to combine liquid chromatography (LC) with mass spectrometry (MS) using a new LC eluent splitting strategy through a tiny orifice on LC capillary tube [ J. Am. Soc. Mass Spectrom. 25, 286 (2014)]. The interface introduces negligible dead volume and back pressure, thereby allowing "near real-time" MS detection, fast LC elution, and online MS-directed purification. This study further evaluates the LC/DESI-MS performance with focus of using ultra-fast LC. Using a monolithic C18 column, metabolites in urine can be separated within 1.6 min and can be online collected for subsequent structure elucidation (e.g., by NMR, UV, IR) in a recovery yield up to 99%. Using a spray solvent with alkaline pH, negative ions could be directly generated for acidic analytes (e.g., ibuprofen) in acidic LC eluent by DESI, offering a novel protocol to realize "wrong-way around" ionization for LC/MS analysis. In addition, DESI-MS is found to be compatible with ultra-performance liquid chromatography (UPLC) for the first time.

  14. Novel Aspects of the DESI Data Acquisition System

    NASA Astrophysics Data System (ADS)

    Beaufore, Lucas; Honscheid, Klaus; Elliott, Ann; Dark Energy Spectroscopic Instrument Collaboration

    2015-04-01

    The Dark Energy Spectroscopic Instrument (DESI) will measure the effect of dark energy on the expansion of the universe. It will obtain optical spectra for tens of millions of galaxies and quasars, constructing a 3-dimensional map spanning the nearby universe to 10 billion light years. The survey will be conducted on the Mayall 4-meter telescope at Kitt Peak National Observatory starting in 2018. In order to achieve these scientific goals the DESI collaboration is building a high throughput spectrograph capable of observing thousands of spectra simultaneously. In this presentation we discuss the DESI instrument control and data acquisition system that is currently being developed to operate the 5,000 fiber positioners in the focal plane, the 10 spectrographs each with three CDD cameras and every other aspect of the instrument. Special emphasis will be given to novel aspects of the design including the use of inexpensive Linux-based microcontrollers such as the Raspberry PI to control a number of DESI hardware components.

  15. Modulators for the S-band test linac at DESY

    SciTech Connect

    Bieler, M.; Choroba, S.; Hameister, J.; Lewin, H.

    1995-07-05

    The development of adequate modulators for high peak power klystrons is one of the focus points for linear collider R&D programs. For the DESY/THD S-band linear collider study 150 MW rf-pulse power at 50 Hz repetition rate and 3 {mu}s pulse duration is required [1]. Two different modulator schemes are under investigation. One is the conventional line type pulser, using a pulse forming network and a step up transformer, the other one is a hard tube pulser, using a dc power source at the full klystron voltage and a switch tube. This paper is focused on the modulator development for the S-band Test Linac at DESY. After a short overview over the test linac and a brief description of the 150 MW S-band klystron the circuitry of the line type pulse (LTP) is given. A hard tube pulser (HTP), which switches the high voltage directly from a storage capacitor to the klystron, has been built up at DESY. Circuitry and the results of the commissioning of the switch tube are reported. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  16. Deep inelastic events containing two forward jets at DESY HERA

    SciTech Connect

    Kwiecinski, J.; Lewis, C.A.; Martin, A.D.

    1998-01-01

    We use the Balitskij-Fadin-Kuraev-Lipatov (BFKL) equation to calculate the rate of deep inelastic scattering events containing two forward jets (adjacent to the proton remnants) at DESY HERA. We compare the production of two forward jets with that of only one forward jet (the {open_quotes}Mueller{close_quotes} process). We obtain a stable prediction for this two to one jet ratio, which may serve as a measure of the BFKL vertex function. {copyright} {ital 1997} {ital The American Physical Society}

  17. The European XFEL Free Electron Laser at DESY

    ScienceCinema

    Weise, Hans [Deutsches Elektronen-Synchrotron, Germany

    2009-09-01

    The European X-ray Free-Electron laser Facility (XFEL) is going to be built in an international collaboration at the Deutsches Elektronen-Synchrotron (DESY), Germany, and the Technical Design Report was published in 2006. The official project is expected for summer 2007. This new facility will offer photon beams at wavelengths as short as 1 angstrom with highest peak brilliance being more than 100 million times higher than present day synchrotron radiation sources. The radiation has a high degree of transverse coherence and the pulse duration is reduced from {approx}100 picoseconds (typ. for SR light sources) down to the {approx}10 femtosecond time domain. The overall layout of the XFEL will be described. This includes the envisaged operation parameters for the linear accelerator using superconducting TESLA technology. The complete design is based on the actually operated FLASH free-electron laser at DESY. Experience with the operation during first long user runs at wavelengths from 30 to 13 nm will be described in detail.

  18. A first calibration study for PINGU at DESY

    SciTech Connect

    Shanidze, R.; Collaboration: IceCube-PINGU Collaboration

    2014-11-18

    PINGU, the Precision IceCube Next Generation Upgrade, aims at lowering the neutrino detection threshold of the IceCube neutrino telescope to a few GeV by adding new in-fill strings to the existing IceCube/DeepCore array. The main goal of the upgrade is to provide sensitivity to the neutrino mass hierarchy utilizing atmospheric neutrinos. Precision reconstruction of the neutrino direction and energy, which is a prerequisite for the determination of the mass hierarchy, requires accurate in-situ calibration and monitoring of the PINGU digital optical modules (PDOMs) and high-level control of systematic effects like those caused by uncertainties in the optical ice properties and sensitivity of the PDOM in ice. These proceedings present an early status of calibration studies for PINGU performed at DESY.

  19. The Dark Energy Spectroscopic Instrument (DESI): The Spectrographs

    NASA Astrophysics Data System (ADS)

    Edelstein, Jerry; DESI Collaboration

    2015-01-01

    The Dark Energy Spectroscopic Instrument (DESI) will conduct a large-area galaxy and quasi-stellar object redshift survey from the Mayall Telescope. It includes of ten spectrographs each recording 500 simultaneous object spectra collected by 5,000 positioned optical fibers in the focal plane of an 8-square degree telescope corrector. The spectrographs use dichroic filters to divide light into three optical channels that together cover the 360 - 980 nm pass band with a spectral resolution of 2,000 to 5,100. Each channel includes a volume phase holographic grating (VPHG) and a 5-element camera that images spectra onto a cryostatic detector. We describe the spectrograph design and predicted performance and the production of the first spectrograph's optical elements.

  20. Merits of online electrochemistry liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS).

    PubMed

    Looi, Wen Donq; Brown, Blake; Chamand, Laura; Brajter-Toth, Anna

    2016-03-01

    A new online electrochemistry/liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS) system with a simple electrochemical thin-layer flow-through cell was developed and tested using N,N-dimethyl-p-phenylenediamine (DMPA) as a model probe. Although oxidation of DMPA is observed as a result of ionization of LS in positive ion mode LS DESI, application of voltage to the online electrochemical (EC) cell in EC/LS DESI MS increases yields of oxidation products. An advantage of LS DESI MS is its sensitivity in aqueous electrolyte solutions, which improves efficiency of electrochemical reactions in EC/LS DESI MS. In highly conductive low pH aqueous buffer solutions, oxidation efficiency is close to 100 %. EC/ESI MS typically requires mixed aqueous/organic solvents and low electrolyte concentrations for efficient ionization in MS, limiting efficiency of electrochemistry online with MS. Independently, the results verify higher electrochemical oxidation efficiency during positive mode ESI than during LS DESI. Graphical abstract Detection of DMPA oxidation in online electrochemical cell with EC/LS DESI MS. PMID:26886744

  1. Detecting Cheatgrass on the Colorado Plateau using Landsat data: A tutorial for the DESI software

    USGS Publications Warehouse

    Kokaly, Raymond F.

    2011-01-01

    Invasive plant species disrupt native ecosystems and cause economic harm to public lands. In this report, an example of applying the Detection of Early Season Invasives software to mapping cheatgrass infestations is given. A discussion of each step of the DESI process is given, including selection of Landsat images. Tutorial data, covering a semi-arid area in southern Utah, are distributed with this report. Tips on deriving the inputs required to run DESI are provided. An approach for evaluating and adjusting detection parameters by examining interim products of DESI is discussed.

  2. The New Hyperspectral Sensor Desis on the Multi-Payload Platform Muses Installed on the Iss

    NASA Astrophysics Data System (ADS)

    Müller, R.; Avbelj, J.; Carmona, E.; Eckardt, A.; Gerasch, B.; Graham, L.; Günther, B.; Heiden, U.; Ickes, J.; Kerr, G.; Knodt, U.; Krutz, D.; Krawczyk, H.; Makarau, A.; Miller, R.; Perkins, R.; Walter, I.

    2016-06-01

    The new hyperspectral instrument DLR Earth Sensing Imaging Spectrometer (DESIS) will be developed and integrated in the Multi-User-System for Earth Sensing (MUSES) platform installed on the International Space Station (ISS). The DESIS instrument will be launched to the ISS mid of 2017 and robotically installed in one of the four slots of the MUSES platform. After a four month commissioning phase the operational phase will last at least until 2020. The MUSES / DESIS system will be commanded and operated by the publically traded company TBE (Teledyne Brown Engineering), which initiated the whole program. TBE provides the MUSES platform and the German Aerospace Center (DLR) develops the instrument DESIS and establishes a Ground Segment for processing, archiving, delivering and calibration of the image data mainly used for scientific and humanitarian applications. Well calibrated and harmonized products will be generated together with the Ground Segment established at Teledyne. The article describes the Space Segment consisting of the MUSES platform and the instrument DESIS as well as the activities at the two (synchronized) Ground Segments consisting of the processing methods, product generation, data calibration and product validation. Finally comments to the data policy are given.

  3. Data preservation for the HERA experiments at DESY using dCache technology

    NASA Astrophysics Data System (ADS)

    Krücker, Dirk; Schwank, Karsten; Fuhrmann, Patrick; Lewendel, Birgit; South, David M.

    2015-12-01

    We report on the status of the data preservation project at DESY for the HERA experiments and present the latest design of the storage which is a central element for bit- preservation. The HEP experiments based at the HERA accelerator at DESY collected large and unique datasets during the period from 1992 to 2007. As part of the ongoing DPHEP data preservation efforts at DESY, these datasets must be transferred into storage systems that keep the data available for ongoing studies and guarantee safe long term access. To achieve a high level of reliability, we use the dCache distributed storage solution and make use of its replication capabilities and tape interfaces. We also investigate a recently introduced Small File Service that allows for the fully automatic creation of tape friendly container files.

  4. The effect of electrospray solvent composition on desorption electrospray ionisation (DESI) efficiency and spatial resolution.

    PubMed

    Green, F M; Salter, T L; Gilmore, I S; Stokes, P; O'Connor, G

    2010-04-01

    In desorption electrospray ionisation (DESI) the interaction between the electrospray and the surface is key to two important analytical parameters, the spatial resolution and the sensitivity. We evaluate the effect of the electrospray solvent type, organic solvent fraction with water, analyte solubility and substrate wettability on DESI erosion diameter and material transferral into useful ion signal. To do this five amino acids, glycine, alanine, valine, leucine and phenylalanine are prepared as thin films on three substrates, UV/ozone treated glass, glass and polytetrafluoroethylene (PTFE). Four different solvents, acetonitrile (ACN), methanol (MeOH), ethanol (EtOH) and propan-2-ol (IPA), are used with organic solvent fractions with water varying from 0.1 to 1. These model systems allow the solubility or wettability to be kept constant as other parameters are varied. Additionally, comparison with electrospray ionisation (ESI) allows effects of ionisation efficiency to be determined. It is shown that the DESI efficiency is linearly dependent on the solubility (for these materials at least) and for analytes with solubilities below 1.5 g kg(-1), additional strategies may be required for DESI to be effective. We show that the DESI erosion diameter improves linearly with organic solvent fraction, with an organic solvent fraction of 0.9 instead of 0.5 leading to a 2 fold improvement. Furthermore, this leads to a 35 fold increase in DESI efficiency, defined as the molecular ion yield per unit area. It is shown that these improvements correlate with smaller droplet sizes rather than surface wetting or ionisation. PMID:20349538

  5. Qualitative analysis of seized cocaine samples using desorption electrospray ionization- mass spectrometry (DESI-MS).

    PubMed

    Stojanovska, Natasha; Tahtouh, Mark; Kelly, Tamsin; Beavis, Alison; Fu, Shanlin

    2015-05-01

    Desorption electrospray ionization - mass spectrometry (DESI-MS) is a useful technique for the qualitative analysis of compounds found in seized drug material. In this study, DESI-MS was utilized in the screening analysis of illicit cocaine samples. The technique was also applied to the geographical origin determination of these samples. The limit of detection was determined to be 24.3 µg (or 3.47 µg/mm(2) ) and the analysis time was less than 1 minute per sample. The intra-day and inter-day precision for the detection of cocaine was 11 % and 42 %, respectively; therefore the quantitative data provided by DESI-MS was limited in its use for accurate determination of cocaine concentration in a sample. Using the quadrupole time-of-flight (QTOF) mass spectrometer, the presence of cocaine and impurities detected were confirmed by accurate tandem MS data. The qualitative chemical profiles obtained using DESI-MS were compared to two popular analysis techniques, GC-MS and LC-MS. The effects of a range of adulterants including caffeine, procaine, levamisole, lignocaine, paracetamol, and atropine on the detectability of cocaine were also investigated. It was found that the addition of these adulterants in a cocaine sample did not prevent the detection of the analyte itself (there was slight enhancement in some samples), which was useful in drug detection. The detection of truxillines in the seized samples by DESI-MS aided in the preliminary determination of geographical origin, i.e., Bolivian, Peruvian or Colombian leaf origin. The application of DESI-MS to the qualitative analysis and screening of seized cocaine samples demonstrates the potential and applicability of the technique to the fast chemical profiling of illicit samples. PMID:24943809

  6. Forensic applications of desorption electrospray ionisation mass spectrometry (DESI-MS).

    PubMed

    Morelato, Marie; Beavis, Alison; Kirkbride, Paul; Roux, Claude

    2013-03-10

    Desorption electrospray ionisation mass spectrometry (DESI-MS) is an emerging analytical technique that enables in situ mass spectrometric analysis of specimens under ambient conditions. It has been successfully applied to a large range of forensically relevant materials. This review assesses and highlights forensic applications of DESI-MS including the analysis and detection of illicit drugs, explosives, chemical warfare agents, inks and documents, fingermarks, gunshot residues and drugs of abuse in urine and plasma specimens. The minimal specimen preparation required for analysis and the sensitivity of detection achieved offer great advantages, especially in the field of forensic science. PMID:23498998

  7. DETECTION OF INTACT PROTEINS WITH DESI-MS: APPLICATION TO MICROORGANISM BIOMARKER DETECTION

    Technology Transfer Automated Retrieval System (TEKTRAN)

    DESI-MS was evaluated with proteins that range in molecular weight from 12 KDa to 66 KDa. Lyophilized protein samples were rehydrated with water, deposited on Plexiglas, and dried. In some experiments buckminsterfullerene (bucky ball, C60) was used as an additive to the nebulizing gas. Optimized ...

  8. Reactive DESI-MS imaging of biological tissues with dicationic ion-pairing compounds.

    PubMed

    Lostun, Dragos; Perez, Consuelo J; Licence, Peter; Barrett, David A; Ifa, Demian R

    2015-03-17

    This work illustrates reactive desorption electrospray ionization mass spectrometry (DESI-MS) with a stable dication on biological tissues. Rat brain and zebra fish tissues were investigated with reactive DESI-MS in which the dictation forms a stable bond with biological tissue fatty acids and lipids. Tandem mass spectrometry (MS/MS) was used to characterize the dication (DC9) and to identify linked lipid-dication compounds formed. The fragment m/z 85 common to both DC9 fragmentation and DC9-lipid fragmentation was used to confirm that DC9 is indeed bonded with the lipids. Lipid signals in the range of m/z 250-350 and phosphoethanolamines (PE) m/z 700-800 observed in negative ion mode were also detected in positive ion mode with reactive DESI-MS with enhanced signal intensity. Reactive DESI-MS imaging in positive ion mode of rat brain and zebra fish tissues allowed enhanced detection of compounds commonly observed in the negative ion mode. PMID:25710577

  9. Improved DESI-MS Performance using Edge Sampling and aRotational Sample Stage

    SciTech Connect

    Kertesz, Vilmos; Van Berkel, Gary J

    2008-01-01

    The position of the surface to be analyzed relative to the sampling orifice or capillary into the mass spectrometer has been known to dramatically affect the observed signal levels in desorption electrospray ionization mass spectrometry (DESIMS). In analyses of sample spots on planar surfaces, DESI-MS signal intensities as much as five times greater were routinely observed when the bottom of the sampling capillary was appropriately positioned beneath the surface plane ( edge sampling") compared to when the capillary just touched the surface. To take advantage of the optimum "edge sampling" geometry and to maximize the number of samples that could be analyzed in this configuration, a rotational sample stage was integrated into a typical DESI-MS setup. The rapid quantitative determination of caffeine in two diet sport drinks (Diet Turbo Tea, Speed Stack Grape) spiked with an isotopically labeled internal standard demonstrated the utility of this approach.

  10. An advanced draft genome assembly of a desi type chickpea (Cicer arietinum L.)

    PubMed Central

    Parween, Sabiha; Nawaz, Kashif; Roy, Riti; Pole, Anil K.; Venkata Suresh, B.; Misra, Gopal; Jain, Mukesh; Yadav, Gitanjali; Parida, Swarup K.; Tyagi, Akhilesh K.; Bhatia, Sabhyata; Chattopadhyay, Debasis

    2015-01-01

    Chickpea (Cicer arietinum L.) is an important pulse legume crop. We previously reported a draft genome assembly of the desi chickpea cultivar ICC 4958. Here we report an advanced version of the ICC 4958 genome assembly (version 2.0) generated using additional sequence data and an improved genetic map. This resulted in 2.7-fold increase in the length of the pseudomolecules and substantial reduction of sequence gaps. The genome assembly covered more than 94% of the estimated gene space and predicted the presence of 30,257 protein-coding genes including 2230 and 133 genes encoding potential transcription factors (TF) and resistance gene homologs, respectively. Gene expression analysis identified several TF and chickpea-specific genes with tissue-specific expression and displayed functional diversification of the paralogous genes. Pairwise comparison of pseudomolecules in the desi (ICC 4958) and the earlier reported kabuli (CDC Frontier) chickpea assemblies showed an extensive local collinearity with incongruity in the placement of large sequence blocks along the linkage groups, apparently due to use of different genetic maps. Single nucleotide polymorphism (SNP)-based mining of intra-specific polymorphism identified more than four thousand SNPs differentiating a desi group and a kabuli group of chickpea genotypes. PMID:26259924

  11. DESI-MS/MS of Chemical Warfare Agents and Related Compounds

    NASA Astrophysics Data System (ADS)

    D'Agostino, Paul A.

    Solid phase microextraction (SPME) fibers were used to headspace ­sample chemical warfare agents and their hydrolysis products from glass vials and glass vials containing spiked media, including Dacron swabs, office carpet, paper and fabric. The interface of the Z-spray source was modified to permit safe introduction of the SPME fibers for desorption electrospray ionization mass spectrometric (DESI-MS) analysis. A "dip and shoot" method was also developed for the rapid sampling and DESI-MS analysis of chemical warfare agents and their hydrolysis products in liquid samples. Sampling was performed by simply dipping fused silica, stainless steel or SPME tips into the organic or aqueous samples. Replicate analyses were completed within several minutes under ambient conditions with no sample pre-treatment, resulting in a significant increase in sample throughput. The developed sample handling and analysis method was applied to the determination of chemical warfare agent content in samples containing unknown chemical and/or biological warfare agents. Ottawa sand was spiked with sulfur mustard, extracted with water and autoclaved to ensure sterility. Sulfur mustard was completely hydrolysed during the extraction/autoclave step and thiodiglycol was identified by DESI-MS, with analyses generally being completed within 1 min using the "dip and shoot" method.

  12. Detection of saccharides by reactive desorption electrospray ionization (DESI) using modified phenylboronic acids

    NASA Astrophysics Data System (ADS)

    Zhang, Yun; Chen, Hao

    2010-01-01

    We have reported previously a method for the detection of sugars via in-situ derivatization with phenylboronic acid PhB(OH)2 using reactive desorption electrospray ionization (DESI, Chen et al., Chem. Commun. (2006) 597-599). The present study describes an improved method that employs modified phenylboronic acids including 3-nitrophenylboronic acid and N-methyl-4-pyridineboronic acid iodide. In contrast to using PhB(OH)2, enhanced sensitivity of using 3-nitrophenylboronic acid was observed due to the stabilization of the resulting boronate ester anion by the electron-withdrawing nitro group and the limit of detections (LODs) for glucose in water using 3-nitrophenylbornic acid and phenylboronic acid were determined to be 0.11 mM and 0.40 mM, respectively. In the case of N-methyl-4-pyridineboronic acid iodide, the corresponding LOD is 6.9 [mu]M and the higher sensitivity obtained is attributed to the efficient ionization of both the reactive DESI reagent and reaction product since the precursor acid with a quaternary ammonium group is pre-charged. In this case, additional important features are found: (i) unlike using phenylboronic acid or 3-nitrophenylbornic acid, the experiment, performed in the positive ion mode, is applicable to neutral and acidic saccharide solutions, facilitating the analysis of biological fluids without the need to adjust pH; (ii) simply by changing the spray solvent from water to acetonitrile, the method can be used for direct glucose analyses of both urine and serum samples via online desalting, due to the low solubility of salts of these biofluids in the sprayed organic solvent; (iii) in comparison with other sugar derivatizing reagents such as the Girard's reagent T, the N-methyl-4-pyridineboronic acid iodide shows higher reactivity in the reactive DESI; and (iv) the ions of saccharide DESI reaction products undergo extensive ring or glycosidic bond cleavage upon CID, a feature that might be useful in the structure elucidation of

  13. Differential response of kabuli and desi chickpea genotypes toward inoculation with PGPR in different soils

    PubMed Central

    Imran, Asma; Mirza, Muhammad S.; Shah, Tariq M.; Malik, Kauser A.; Hafeez, Fauzia Y.

    2015-01-01

    Pakistan is among top three chickpea producing countries but the crop is usually grown on marginal lands without irrigation and fertilizer application which significantly hampers its yield. Soil fertility and inoculation with beneficial rhizobacteria play a key role in nodulation and yield of legumes. Four kabuli and six desi chickpea genotypes were, therefore, evaluated for inoculation response with IAA-producing Ochrobactrum ciceri Ca-34T and nitrogen fixing Mesorhizobium ciceri TAL-1148 in single and co-inoculation in two soils. The soil type 1 was previously unplanted marginal soil having low organic matter, P and N contents compared to soil type 2 which was a fertile routinely legume-cultivated soil. The effect of soil fertility status was pronounced and fertile soil on average, produced 31% more nodules, 62% more biomass and 111% grain yield than marginal soil. Inoculation either with O. ciceri alone or its co-inoculation with M. ciceri produced on average higher nodules (42%), biomass (31%), grains yield (64%) and harvest index (72%) in both chickpea genotypes over non-inoculated controls in both soils. Soil 1 showed maximum relative effectiveness of Ca-34T inoculation for kabuli genotypes while soil 2 showed for desi genotypes except B8/02. Desi genotype B8/02 in soil type 1 and Pb-2008 in soil type 2 showed significant yield increase as compared to respective un-inoculated controls. Across bacterial inoculation treatments, grain yield was positively correlated to growth and yield contributing parameters (r = 0.294* to 0.838*** for desi and r = 0.388* to 0.857** for kabuli). PCA and CAT-PCA analyses clearly showed a site-specific response of genotype x bacterial inoculation. Furthermore, the inoculated bacterial strains were able to persist in the rhizosphere showing colonization on root and within nodules. Present study shows that plant growth promoting rhizobacteria (PGPR) inoculation should be integrated with national chickpea breading program in

  14. Monitoring of changes in lipid profiles during PLK1 knockdown in cancer cells using DESI MS.

    PubMed

    Jayashree, Balasubramanyam; Srimany, Amitava; Jayaraman, Srinidhi; Bhutra, Anjali; Janakiraman, Narayanan; Chitipothu, Srujana; Krishnakumar, Subramanian; Baddireddi, Lakshmi Subhadra; Elchuri, Sailaja; Pradeep, Thalappil

    2016-08-01

    The importance of the polo-like kinase 1 (PLK1) gene is increasing substantially both as a biomarker and as a target for highly specific cancer therapy. This is due to its involvement in multiple points of cell progression and carcinogenesis. PLK1 inhibitors' efficacy in treating human cancers has been limited due to the lack of a specific targeting strategy. Here, we describe a method of targeted downregulation of PLK1 in cancer cells and the concomitant rapid detection of surface lipidomic perturbations using desorption electrospray ionization mass spectrometry (DESI MS). The efficient delivery of siRNA targeting PLK1 gene selectively to the cancer cells is achieved by targeting overexpressed cell surface epithelial cell adhesion molecule (EpCAM) by the EpDT3 aptamer. The chimeric aptamer (EpDT3-siPLK1) showed the knockdown of PLK1 gene expression and PLK1 protein levels by quantitative PCR and western blotting, respectively. The abundant surface lipids, phosphatidylcholines (PCs), such as PC(32:1) (m/z 754.6), PC(34:1) (m/z 782.6), and PC(36:2) (m/z 808.6), were highly expressed in MCF-7 and WERI-RB1 cancer cells compared to normal MIO-M1 cells and they were observed using DESI MS. These overexpressed cell surface lipids in the cancer cells were downregulated upon the treatment of EpDT3-siPLK1 chimera indicating a novel role of PLK1 to regulate surface lipid expression in addition to the efficient selective cancer targeting ability. Our results indicate that DESI MS has a potential ability to rapidly monitor aptamer-mediated cancer therapy and accelerate the drug discovery process. Graphical abstract Binding of aptamer chimera to the cells and changes in lipid profile. PMID:27277815

  15. Transatlantic Transport of Fermilab 3.9 GHZ Cryomodule to DESY

    SciTech Connect

    McGee, M.W.; Grimm, C.; Olis, D.; Schappert, Warren; /Fermilab

    2009-05-01

    In an exchange of technology agreement, Fermilab has built and delivered a 3.9 GHz (3rd harmonic) cryomodule to Deutsches Elektron-Synchrotron (DESY) Laboratory to be installed in the TTF/FLASH beamline. Transport to Hamburg, Germany was completed via a combination of flatbed air ride truck and commercial aircraft, while minimizing transition or handling points. Initially, destructive testing of fragile components, transport and corresponding alignment stability studies were performed in order to assess the risk associated with transatlantic travel of a fully assembled cryomodule. Data logged triaxial acceleration results of the transport with a comparison to the transport study predicted values are presented.

  16. Analysis of DESY-Flash LLRF Measurements for the ILC Heavy Beam Loading Test

    SciTech Connect

    Cancelo, Gustavo; Chase, Brian; Davidsaver, Michael; Carwardine, J.; Simrock, Stefan; Ayvazyan, Valeri; Grecki, Mariusz; Matsumoto, Toshihiro; Michizono, Shinichiro; /KEK, Tsukuba

    2009-06-01

    In September 2008 the DESY-FLASH accelerator was run with up to 550, 3 nano-coulomb bunches at 5 Hz repetition rate. This test is part of a longer-term study aimed at validating ILC parameters by operation as close as possible to ILC beam currents and RF gradients. The present paper reports on the analysis that has been done in order to understand the RF control system performance during this test. Actual klystron power requirements and beam stability are evaluated with heavy beam loading conditions. Results include suggested improvements for upcoming tests in 2009.

  17. Blotting Assisted by Heating and Solvent Extraction for DESI-MS Imaging

    NASA Astrophysics Data System (ADS)

    Cabral, Elaine C.; Mirabelli, Mario F.; Perez, Consuelo J.; Ifa, Demian R.

    2013-06-01

    Imprints of potato sprout ( Solanum tuberosum L.), gingko leaves (Gingko biloba L. ) and strawberries (Fragaria x ananassa Duch. ) were successfully imaged by desorption electrospray ionization mass spectrometry (DESI-MS) on TLC plates through blotting assisted by heating and/or solvent extraction. Ion images showing the distribution of significant compounds such as glycoalkaloid toxins in potato sprout, ginkgolic acids and flavonoids in ginkgo leaves, and sugars and anthocyanidin in strawberry were obtained. Practical implications of this work include analysis of a wide range of irregular or soft materials by different imprinting conditions without requiring the addition of matrices or use of specific kinds of surfaces.

  18. HPTLC/DESI-MS Imaging of Tryptic Protein Digests Separated in Two Dimensions

    SciTech Connect

    Pasilis, Sofie P; Kertesz, Vilmos; Van Berkel, Gary J; Schulz, Michael; Schorcht, Susanne

    2008-01-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) was demonstrated as a method to detect and identify peptides from two-dimensional separations of cytochrome c and myoglobin tryptic digests on ProteoChrom HPTLC Cellulose sheets. Data-dependent tandem mass spectra were acquired during lane scans across the TLC plates. Peptides and the corresponding proteins were identified using a protein database search software. Two-dimensional distributions of identified peptides were mapped for each separated protein digest. Sequence coverages for cytochrome c and myoglobin were 81% and 74%, respectively. These compared well to those determined using the more standard HPLC/ESI-MS/MS approach (89% and 84%, respectively). Preliminary results show that use of more sensitive instrumentation has the potential for improved detection of peptides with low Rf values and improvement in sequence coverage. However, less multiple charging and more sodiation were seen in HPTLC/DESI-MS spectra relative to HPLC/ESI-MS spectra, which can affect peptide identification by MS/MS. Methods to increase multiple charging and reduce the extent of sodiation are currently under investigation.

  19. DESI and other Dark Energy experiments in the era of neutrino mass measurements

    SciTech Connect

    Font-Ribera, Andreu; McDonald, Patrick; Mostek, Nick; Reid, Beth A.; Seo, Hee-Jong; Slosar, Anže E-mail: PVMcDonald@lbl.gov E-mail: BAReid@lbl.gov E-mail: anze@bnl.gov

    2014-05-01

    We present Fisher matrix projections for future cosmological parameter measurements, including neutrino masses, Dark Energy, curvature, modified gravity, the inflationary perturbation spectrum, non-Gaussianity, and dark radiation. We focus on DESI and generally redshift surveys (BOSS, HETDEX, eBOSS, Euclid, and WFIRST), but also include CMB (Planck) and weak gravitational lensing (DES and LSST) constraints. The goal is to present a consistent set of projections, for concrete experiments, which are otherwise scattered throughout many papers and proposals. We include neutrino mass as a free parameter in most projections, as it will inevitably be relevant — DESI and other experiments can measure the sum of neutrino masses to ∼ 0.02 eV or better, while the minimum possible sum is ∼ 0.06 eV. We note that constraints on Dark Energy are significantly degraded by the presence of neutrino mass uncertainty, especially when using galaxy clustering only as a probe of the BAO distance scale (because this introduces additional uncertainty in the background evolution after the CMB epoch). Using broadband galaxy power becomes relatively more powerful, and bigger gains are achieved by combining lensing survey constraints with redshift survey constraints. We do not try to be especially innovative, e.g., with complex treatments of potential systematic errors — these projections are intended as a straightforward baseline for comparison to more detailed analyses.

  20. The National Analysis Facility at DESY - status and use cases by the participating experiments

    NASA Astrophysics Data System (ADS)

    Aplin, S.; Ehrenfeld, W.; Haupt, A.; Kemp, Y.; Langenbruch, C.; Leffhalm, K.; Lucaci-Timoce, A.; Stadie, H.

    2011-12-01

    The German National Analysis Facility (NAF) was set up at DESY, starting end of 2007 in the context of the Helmholtz Alliance "Physics at the Terascale". The NAF complements the DESY and the German Grid resources, and hence offers users from the German HEP institutes the best possible environment for data analysis. In the first part, the key aspects and components of the NAF are briefly presented with an emphasis on recent improvements. In the second part, the use cases of the three participating LHC experiments, ATLAS, CMS and LHCb, will be presented. Differences and commonalities in the usage of the NAF will be shown. Special emphasis will be placed on the usage of PROOF, whose usage on the NAF has been pioneered by CMS. It is now adapted by ATLAS. The third part will concentrate on how the NAF was used for detector optimisation studies in the preparation of one of the ILC Lol's (ILD 2009), as well as how CALICE uses the NAF for the analysis of their data taken in several test beam experiments performed for detector R & D. Finally, future developments of the NAF are presented.

  1. SINBAD-The accelerator R&D facility under construction at DESY

    NASA Astrophysics Data System (ADS)

    Dorda, U.; Assmann, R.; Brinkmann, R.; Flöttmann, K.; Hartl, I.; Hüning, M.; Kärtner, F.; Fallahi, A.; Marchetti, B.; Nie, Y.; Osterhoff, J.; Schlarb, H.; Zhu, J.; Maier, A. R.

    2016-09-01

    The SINBAD facility (Short INnovative Bunches and Accelerators at DESY) is a long-term dedicated accelerator research and development facility currently under construction at DESY. It will be located in the premises of the old DORIS accelerator complex and host multiple independent experiments cost-effectively accessing the same central infrastructure like a central high power laser. With the removal of the old DORIS accelerator being completed, the refurbishment of the technical infrastructure is currently starting up. The presently ongoing conversion of the area into the SINBAD facility and the currently foreseen layout is described. The first experiment will use a compact S-band linac for the production of ultra-short bunches at hundred MeV. Once established, one of the main usages will be to externally inject electrons into a laser-driven plasma wakefield accelerator to boost the energy to GeV-level while maintaining a usable beam quality, ultimately aiming to drive an FEL. The second experiment already under planning is the setup of an attosecond radiation source with advanced technology. Further usage of the available space and infrastructure is revised and national and international collaborations are being established.

  2. Advances in Large Grain/Single Crystal SC Resonators at DESY

    SciTech Connect

    W. Singer; A. Brinkmann; A. Ermakov; J. Iversen; G. Kreps; A. Matheisen; D. Proch; D. Reschke; X. Singer; M. Spiwek; H. We; P. Kneisel; M. Pekeler

    2007-08-01

    The main aim of the DESY large grain R&D program is to check whether this option is reasonable to apply for fabrication of ca. 1'000 XFEL cavities. Two aspects are being pursued. On one hand the basic material investigation, on the other hand the material availability, fabrication and preparation procedure. Several single cell large grain cavities of TESLA shape have been fabricated and tested. The best accelerating gradients of 41 MV/m was measured on electropolished cavity. First large grain nine-cell cavities worldwide have been produced under contract of DESY with ACCEL Instruments Co. All three cavities fulfil the XFEL specification already in first RF test after only BCP (Buffered Chemical Polishing) treatment and 800 degrees C annealing. Accelerating gradient of 27 - 29 MV/m was reached. A fabrication method of single crystal cavity of ILC like shape was proposed. A single cell single crystal cavity was build at the company ACCEL. Accelerating gradient of 37.5 MV/m reached after only 112 microns BCP and in situ baking 120 degrees C for 6 hrs with the quality factor higher as 2x1010. The developed method can be extended on fabrication of multi cell single crystal cavities.

  3. Analysis of Metabolic Changes in Plant Pathosystems by Imprint Imaging DESI-MS

    NASA Astrophysics Data System (ADS)

    Tata, Alessandra; Perez, Consuelo J.; Hamid, Tanam S.; Bayfield, Mark A.; Ifa, Demian R.

    2015-04-01

    The response of plants to microbial pathogens is based on the production of secondary metabolites. The complexity of plant-pathogen interactions makes their understanding a challenging task for metabolomic studies requiring powerful analytical approaches. In this paper, the ability of ambient mass spectrometry to provide a snapshot of plant metabolic response to pathogen invasion was tested. The fluctuations of glycoalkaloids present in sprouted potatoes infected by the phytopathogen Pythium ultimum were monitored by imprint imaging desorption electrospray ionization mass spectrometry (DESI-MS). After 8 d from the inoculation, a decrease of the relative abundance of potato glycoalkaloids α-solanine ( m/z 706) and α-chaconine ( m/z 722) was observed, whereas the relative intensity of solanidine ( m/z 398), solasodenone ( m/z 412), solanaviol ( m/z 430), solasodiene ( m/z 396), solaspiralidine ( m/z 428), γ-solanine/γ-chaconine ( m/z 560) , β-solanine ( m/z 706), and β-chaconine ( m/z 722) increased. The progression of the disease, expressed by the development of brown necrotic lesions on the potato, led to the further decrease of all the glycoalkaloid metabolites. Therefore, the applicability of imprint imaging DESI-MS in studying the plant metabolic changes in a simple pathosystem was demonstrated with minimal sample preparation.

  4. Upgrade of the H^--injection system at the DESY proton Linac III

    NASA Astrophysics Data System (ADS)

    Kleffner, C.-M.; Holtkamp, N.; Jacobs, G.; Nagl, M.; Deitinghoff, H.; Paramonov, V.

    1997-05-01

    In the near future an upgrade of the injection system of the proton linac at DESY is foreseen. Two different types of H^--sources are operated at DESY. The new rf-driven volume source is cesium free. On a long-term basis this source is planned to replace the operating magnetron source. For reasons of reliability of the proton linac and further developments of sources parallel operation of two sources should be possible at the the Alvarez linac. Each source has a separate RFQ to accelerate the ions to an energy of 750 keV. A new transport line with one dipole, 8 quadrupoles and one intermediate buncher was designed to match the beam between both RFQs and the Alvarez linac. The codes COPPOC and TRANSPORT were used for determining the length of the transport line and the parameters of the dipole and the buncher. Because of the high currents of more than 20 mA the estimate of the space charge forces is of special interest. The macro-particle-code PARMTRA takes into account the particle-to-particle electric forces among all particles. The properties of the beam line have been studied in connection with the effects of the final beam quality after acceleration with the 50 MeV Alvarez linac.

  5. A VUV free electron laser at the TESLA test facility at DESY

    NASA Astrophysics Data System (ADS)

    Rossbach, J.; Tesla Fel Study Group

    1996-02-01

    We present the layout of a single pass free electron laser (FEL) to be driven by the TESLA Test Facility (TTF) currently under construction at DESY. The TTF is a test-bed for high-gradient, high efficiency superconducting acceleration sections for a future linear collider. Due to its unrivaled ability to sustain high beam quality during acceleration, a superconducting rf linac is considered the optimum choice to drive a FEL. We aim at a photon wavelength of λ = 6 nm utilizing the TTF after it has been extended to 1 GeV beam energy. Due to lack of mirrors and seed-lasers in this wavelength regime, a single pass FEL and self-amplified spontaneous emission (SASE) is considered. A first test is foreseen at a larger photon wavelength. The overall design as well as both electron and photon beam properties are discussed.

  6. Review of R&D at DESY on ingot niobium for accelerators

    NASA Astrophysics Data System (ADS)

    Navitski, Aliaksandr; Sekutowicz, Jacek; Singer, Waldemar; Singer, Xenia

    2015-12-01

    An R&D program at DESY exploring the potential of the production of 1.3 GHz TESLA shape cavities from large grain or ingot niobium material has been carried out as a feasibility study for using ingot niobium material for the European X-ray Free-Electron Laser project. The most important issues like feasibility of the fabrication of niobium discs from ingots, material properties, cavity fabrication, treatment, and finally the cryogenic radiofrequency (RF) performance of the cavity in the accelerator modules are presented and discussed. At least 25% higher intrinsic quality factor comparing to conventional fine-grain niobium and high accelerating gradient of up to 45 MV/m have been demonstrated during the cryogenic RF tests both in the vertical cryostats and in a completely assembled accelerating cryo-module.

  7. Potential applications of the dielectric wakefield accelerators in the SINBAD facility at DESY

    NASA Astrophysics Data System (ADS)

    Nie, Y. C.; Assmann, R.; Dorda, U.; Marchetti, B.; Weikum, M.; Zhu, J.; Hüning, M.

    2016-09-01

    Short, high-brightness relativistic electron bunches can drive ultra-high wakefields in the dielectric wakefield accelerators (DWFAs). This effect can be used to generate high power THz coherent Cherenkov radiation, accelerate a witness bunch with gradient two or three orders of magnitude larger than that in the conventional RF linear accelerators, introduce energy modulation within the driving bunch itself, etc. The paper studies potential applications of the DWFAs in the SINBAD facility at DESY. The simulations show that the ultra-short relativistic bunches from the SINBAD injector ARES can excite accelerating wakefields with peak amplitudes as high as GV/m at THz frequencies in proper DWFA structures. In addition, it illustrates that the DWFA structure can serve as a dechirper to compensate the correlated energy spread of the bunches accelerated by the laser plasma wakefield accelerator.

  8. HARWI-II, The New High-Energy Beamline for Materials Science at HASYLAB/DESY

    SciTech Connect

    Beckmann, Felix; Lippmann, Thomas; Metge, Joachim; Dose, Thomas; Donath, Tilman; Schreyer, Andreas; Tischer, Markus; Liss, Klaus Dieter

    2004-05-12

    The GKSS Forschungszentrum Geesthacht, Germany, will setup a new high-energy beamline specialized for texture, strain and imaging measurements for materials science at the Hamburger Synchrotronstrahlungslabor HASYLAB of the Deutsches Elektronen-Synchrotron DESY. Four different experiments will be installed at the new wiggler HARWI-II. The high pressure cell will be run by the GFZ Potsdam, Germany, the high-energy diffractometer together with a microtomography camera will be run by the GKSS. A further station will allow space for the diffraction enhanced imaging setup. The optics will provide for a small white beam (0.5 mm x 0.5 mm) and a large monochromatic X-ray beam (50 mm x 10 mm) with an energy range of 20 to 250 keV.

  9. Review of R&D at DESY on ingot niobium for accelerators

    SciTech Connect

    Navitski, Aliaksandr Sekutowicz, Jacek Singer, Waldemar Singer, Xenia

    2015-12-04

    An R&D program at DESY exploring the potential of the production of 1.3 GHz TESLA shape cavities from large grain or ingot niobium material has been carried out as a feasibility study for using ingot niobium material for the European X-ray Free-Electron Laser project. The most important issues like feasibility of the fabrication of niobium discs from ingots, material properties, cavity fabrication, treatment, and finally the cryogenic radiofrequency (RF) performance of the cavity in the accelerator modules are presented and discussed. At least 25% higher intrinsic quality factor comparing to conventional fine-grain niobium and high accelerating gradient of up to 45 MV/m have been demonstrated during the cryogenic RF tests both in the vertical cryostats and in a completely assembled accelerating cryo-module.

  10. A Combined Desorption Ionization by Charge Exchange (DICE) and Desorption Electrospray Ionization (DESI) Source for Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Chan, Chang-Ching; Bolgar, Mark S.; Miller, Scott A.; Attygalle, Athula B.

    2011-01-01

    A source that couples the desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) techniques together was demonstrated to broaden the range of compounds that can be analyzed in a single mass spectrometric experiment under ambient conditions. A tee union was used to mix the spray reagents into a partially immiscible blend before this mixture was passed through a conventional electrospray (ES) probe capillary. Using this technique, compounds that are ionized more efficiently by the DICE method and those that are ionized better with the DESI procedure could be analyzed simultaneously. For example, hydroquinone, which is not detected when subjected to DESI-MS in the positive-ion generation mode, or the sodium adduct of guaifenesin, which is not detected when examined by DICE-MS, could both be detected in one experiment when the two techniques were combined. The combined technique was able to generate the molecular ion, proton and metal adduct from the same compound. When coupled to a tandem mass spectrometer, the combined source enabled the generation of product ion spectra from the molecular ion and the [M + H]+ or [M + metal]+ ions of the same compound without the need to physically change the source from DICE to DESI. The ability to record CID spectra of both the molecular ion and adduct ions in a single mass spectrometric experiment adds a new dimension to the array of mass spectrometric methods available for structural studies.

  11. A combined desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) source for mass spectrometry.

    PubMed

    Chan, Chang-Ching; Bolgar, Mark S; Miller, Scott A; Attygalle, Athula B

    2011-01-01

    A source that couples the desorption ionization by charge exchange (DICE) and desorption electrospray ionization (DESI) techniques together was demonstrated to broaden the range of compounds that can be analyzed in a single mass spectrometric experiment under ambient conditions. A tee union was used to mix the spray reagents into a partially immiscible blend before this mixture was passed through a conventional electrospray (ES) probe capillary. Using this technique, compounds that are ionized more efficiently by the DICE method and those that are ionized better with the DESI procedure could be analyzed simultaneously. For example, hydroquinone, which is not detected when subjected to DESI-MS in the positive-ion generation mode, or the sodium adduct of guaifenesin, which is not detected when examined by DICE-MS, could both be detected in one experiment when the two techniques were combined. The combined technique was able to generate the molecular ion, proton and metal adduct from the same compound. When coupled to a tandem mass spectrometer, the combined source enabled the generation of product ion spectra from the molecular ion and the [M + H](+) or [M + metal](+) ions of the same compound without the need to physically change the source from DICE to DESI. The ability to record CID spectra of both the molecular ion and adduct ions in a single mass spectrometric experiment adds a new dimension to the array of mass spectrometric methods available for structural studies. PMID:21472555

  12. A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue

    NASA Astrophysics Data System (ADS)

    Abbassi-Ghadi, Nima; Jones, Emrys A.; Gomez-Romero, Maria; Golf, Ottmar; Kumar, Sacheen; Huang, Juzheng; Kudo, Hiromi; Goldin, Rob D.; Hanna, George B.; Takats, Zoltan

    2016-02-01

    In this study, we make a direct comparison between desorption electrospray ionization-mass spectrometry (DESI-MS) and ultraperformance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS) platforms for the profiling of glycerophospholipid (GPL) species in esophageal cancer tissue. In particular, we studied the similarities and differences in the range of GPLs detected and the congruency of their relative abundances as detected by each analytical platform. The main differences between mass spectra of the two modalities were found to be associated with the variance in adduct formation of common GPLs, rather than the presence of different GPL species. Phosphatidylcholines as formate adducts in UPLC-ESI-MS accounted for the majority of differences in negative ion mode and alkali metal adducts of phosphatidylcholines in DESI-MS for positive ion mode. Comparison of the relative abundance of GPLs, normalized to a common peak, revealed a correlation coefficient of 0.70 ( P < 0.001). The GPL profile detected by DESI-MS is congruent to UPLC-ESI-MS, which reaffirms the role of DESI-MS for lipidomic profiling and a potential premise for quantification.

  13. A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue.

    PubMed

    Abbassi-Ghadi, Nima; Jones, Emrys A; Gomez-Romero, Maria; Golf, Ottmar; Kumar, Sacheen; Huang, Juzheng; Kudo, Hiromi; Goldin, Rob D; Hanna, George B; Takats, Zoltan

    2016-02-01

    In this study, we make a direct comparison between desorption electrospray ionization-mass spectrometry (DESI-MS) and ultraperformance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS) platforms for the profiling of glycerophospholipid (GPL) species in esophageal cancer tissue. In particular, we studied the similarities and differences in the range of GPLs detected and the congruency of their relative abundances as detected by each analytical platform. The main differences between mass spectra of the two modalities were found to be associated with the variance in adduct formation of common GPLs, rather than the presence of different GPL species. Phosphatidylcholines as formate adducts in UPLC-ESI-MS accounted for the majority of differences in negative ion mode and alkali metal adducts of phosphatidylcholines in DESI-MS for positive ion mode. Comparison of the relative abundance of GPLs, normalized to a common peak, revealed a correlation coefficient of 0.70 (P < 0.001). The GPL profile detected by DESI-MS is congruent to UPLC-ESI-MS, which reaffirms the role of DESI-MS for lipidomic profiling and a potential premise for quantification. PMID:26466600

  14. On-probe pyrolysis desorption ecectrospray ionization (DESI) mass spectrometry for the analysis of non-volatile pyrolysis products

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An on-probe pyrolyzer has been constructed and interfaced with desorption electrospray ionization (DESI) mass spectrometry (MS) for the rapid analysis of non-volatile pyrolysis products. The detection and analysis of non-volatile pyrolysis products of peptides, proteins and the synthetic polymer pol...

  15. Prospects of Hybrid Plasma- and Radiofrequency-Based Electron Acceleration at DESY

    NASA Astrophysics Data System (ADS)

    Osterhoff, Jens; Gruener, Florian; Elsen, Eckhard; Floettmann, Klaus; Foster, Brian; Brinkmann, Reinhard; Schmidt, Bernhard; Schlarb, Holger; Stephan, Frank

    2012-10-01

    The field of particle acceleration in plasma wakes has seen remarkable progress in recent years. Accelerating gradients of more than 10 GV/m can now be readily achieved using either ultra-short intense laser pulses or particle beams as wake drivers. The demonstration of the first GeV electron beams and a general trend towards improved reproducibility, beam quality and control over the involved plasma processes has led to plasma-acceleration techniques beginning to draw considerable interest in the traditional accelerator community. As a consequence, DESY, Germany's leading accelerator center, has established a research program for plasma-based novel acceleration techniques with the goal of exploiting the synergetic combination of conventional and new accelerator technology. Such a concept offers an attractive pathway to study many mechanisms occurring in plasma-based accelerators, for example electron-beam-emittance evolution, extreme bunch compression, the controlled emission of betatron radiation, and staging of accelerating units. In addition, it is assumed that bypassing the difficult-to-master process of particle self-injection, which is utilized in all current laser-plasma acceleration schemes, will greatly enhance the reliability of such machines compared to the state-of-the-art.

  16. Properties of hadronic final states in diffractive deep inelastic ep scattering at DESY HERA

    NASA Astrophysics Data System (ADS)

    Chekanov, S.; Derrick, M.; Krakauer, D.; Magill, S.; Musgrave, B.; Pellegrino, A.; Repond, J.; Yoshida, R.; Mattingly, M. C.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Romeo, G. Cara; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; de Pasquale, S.; Giusti, P.; Iacobucci, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Palmonari, F.; Pesci, A.; Sartorelli, G.; Zichichi, A.; Aghuzumtsyan, G.; Brock, I.; Goers, S.; Hartmann, H.; Hilger, E.; Irrgang, P.; Jakob, H.-P.; Kappes, A.; Katz, U. F.; Kerger, R.; Kind, O.; Paul, E.; Rautenberg, J.; Schnurbusch, H.; Stifutkin, A.; Tandler, J.; Voss, K. C.; Weber, A.; Wieber, H.; Bailey, D. S.; Brook, N. H.; Cole, J. E.; Foster, B.; Heath, G. P.; Heath, H. F.; Robins, S.; Rodrigues, E.; Scott, J.; Tapper, R. J.; Wing, M.; Capua, M.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Jeoung, H. Y.; Kim, J. Y.; Lee, J. H.; Lim, I. T.; Ma, K. J.; Pac, M. Y.; Caldwell, A.; Helbich, M.; Liu, W.; Liu, X.; Mellado, B.; Paganis, S.; Sampson, S.; Schmidke, W. B.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Klimek, K.; Olkiewicz, K.; Przybycień, M. B.; Stopa, P.; Zawiejski, L.; Bednarek, B.; Grabowska-Bold, I.; Jeleń, K.; Kisielewska, D.; Kowal, A. M.; Kowal, M.; Kowalski, T.; Mindur, B.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Szuba, D.; Szuba, J.; Kotański, A.; Bauerdick, L. A.; Behrens, U.; Borras, K.; Chiochia, V.; Crittenden, J.; Dannheim, D.; Desler, K.; Drews, G.; Fox-Murphy, A.; Fricke, U.; Geiser, A.; Goebel, F.; Göttlicher, P.; Graciani, R.; Haas, T.; Hain, W.; Hartner, G. F.; Hebbel, K.; Hillert, S.; Koch, W.; Kötz, U.; Kowalski, H.; Labes, H.; Löhr, B.; Mankel, R.; Martens, J.; Martínez, M.; Milite, M.; Moritz, M.; Notz, D.; Petrucci, M. C.; Polini, A.; Schneekloth, U.; Selonke, F.; Stonjek, S.; Wolf, G.; Wollmer, U.; Whitmore, J. J.; Wichmann, R.; Youngman, C.; Zeuner, W.; Coldewey, C.; Viani, A. Lopez-Duran; Meyer, A.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Pelfer, P. G.; Bamberger, A.; Benen, A.; Coppola, N.; Markun, P.; Raach, H.; Wölfle, S.; Bell, M.; Bussey, P. J.; Doyle, A. T.; Glasman, C.; Lee, S. W.; Lupi, A.; McCance, G. J.; Saxon, D. H.; Skillicorn, I. O.; Bodmann, B.; Gendner, N.; Holm, U.; Salehi, H.; Wick, K.; Yildirim, A.; Ziegler, A.; Carli, T.; Garfagnini, A.; Gialas, I.; Lohrmann, E.; Foudas, C.; Gonçalo, R.; Long, K. R.; Metlica, F.; Miller, D. B.; Tapper, A. D.; Walker, R.; Cloth, P.; Filges, D.; Kuze, M.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Ahn, S. H.; Lee, S. B.; Park, S. K.; Lim, H.; Son, D.; Barreiro, F.; García, G.; González, O.; Labarga, L.; del Peso, J.; Redondo, I.; Terrón, J.; Vázquez, M.; Barbi, M.; Bertolin, A.; Corriveau, F.; Ochs, A.; Padhi, S.; Stairs, D. G.; Tsurugai, T.; Antonov, A.; Bashkirov, V.; Danilov, P.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Golubkov, Yu. A.; Katkov, I. I.; Khein, L. A.; Korotkova, N. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Solomin, A. N.; Vlasov, N. N.; Zotkin, S. A.; Bokel, C.; Engelen, J.; Grijpink, S.; Maddox, E.; Koffeman, E.; Kooijman, P.; Schagen, S.; Tassi, E.; Tiecke, H.; Tuning, N.; Velthuis, J. J.; Wiggers, L.; de Wolf, E.; Brümmer, N.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Ginsburg, C. M.; Kim, C. L.; Ling, T. Y.; Boogert, S.; Cooper-Sarkar, A. M.; Devenish, R. C.; Ferrando, J.; Große-Knetter, J.; Matsushita, T.; Rigby, M.; Ruske, O.; Sutton, M. R.; Walczak, R.; Brugnera, R.; Carlin, R.; Corso, F. Dal; Dusini, S.; Limentani, S.; Longhin, A.; Parenti, A.; Posocco, M.; Stanco, L.; Turcato, M.; Adamczyk, L.; Iannotti, L.; Oh, B. Y.; Saull, P. R.; Toothacker, W. S.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cormack, C.; Hart, J. C.; McCubbin, N. A.; Epperson, D.; Heusch, C.; Sadrozinski, H.; Seiden, A.; Williams, D. C.; Park, I. H.; Pavel, N.; Abramowicz, H.; Dagan, S.; Gabareen, A.; Kananov, S.; Kreisel, A.; Levy, A.; Abe, T.; Fusayasu, T.; Kohno, T.; Umemori, K.; Yamashita, T.; Hamatsu, R.; Hirose, T.; Inuzuka, M.; Kitamura, S.; Matsuzawa, K.; Nishimura, T.; Arneodo, M.; Cartiglia, N.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Monaco, V.; Peroni, C.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Bailey, D. C.; Fagerstroem, C.-P.; Galea, R.; Koop, T.; Levman, G. M.; Martin, J. F.; Mirea, A.; Sabetfakhri, A.; Butterworth, J. M.; Gwenlan, C.; Hall-Wilton, R.; Hayes, M. E.; Heaphy, E. A.; Jones, T. W.; Lane, J. B.; Lightwood, M. S.; West, B. J.; Ciborowski, J.; Ciesielski, R.; Grzelak, G.; Nowak, R. J.; Pawlak, J. M.; Smalska, B.; Tymieniecka, T.; Ukleja, A.; Ukleja, J.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Plucinski, P.; Sztuk, J.; Eisenberg, Y.; Gladilin, L. K.; Hochman, D.; Karshon, U.; Breitweg, J.; Chapin, D.; Cross, R.; Kçira, D.; Lammers, S.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Deshpande, A.; Dhawan, S.; Hughes, V. W.; Straub, P. B.; Bhadra, S.; Catterall, C. D.; Frisken, W. R.; Khakzad, M.; Menary, S.

    2002-03-01

    Characteristics of the hadronic final state of diffractive deep inelastic scattering events ep-->eXp were studied in the kinematic range 4DESY ep collider HERA using an integrated luminosity of 13.8 pb-1. The events were tagged by identifying the diffractively scattered proton using the leading proton spectrometer. The properties of the hadronic final state X were studied in its center-of-mass frame using thrust, thrust angle, sphericity, energy flow, transverse energy flow, and ``seagull'' distributions. As the invariant mass of the system increases, the final state becomes more collimated, more aligned, and more asymmetric in the average transverse momentum with respect to the direction of the virtual photon. Comparisons of the properties of the hadronic final state with predictions from various Monte Carlo model generators suggest that the final state is dominated by qq&;g states at the parton level.

  17. Studies on a VUV free electron laser at the TESLA Test Facility at DESY

    SciTech Connect

    Rossbach, J.

    1995-12-31

    The TESLA Test Facility (TTF) currently under construction at DESY is a test-bed for acceleration sections of a high-gradient, high efficiency superconducting linear collider. Due to ist unrivaled ability to sustain high beam quality during acceleration, a superconducting rf linac is considered the optimum choice to drive a Free Electron Laser (FEL). We aim at a photon wavelength of {lambda} = 6 manometer utilizing the TTF after is has been extended to 1 GeV beam energy. Due to lack of mirrors and seed-lasers in this wavelength regime, a single pass FEL and Self-Amplified-Spontaneous-Emission (SASE) is considered. A first test is foreseen at a larger photon wavelength. The overall design as well as both electron and photon beam properties will be discussed. To reach the desired photon wavelength, the main components that have to be added to the TTF are: (a) a low emittance rf gun including space charge compensation (b) a two stage bunch compressor increasing the peak bunch current from 100 A up to 2500 A (c) four more accelerating modules to achieve 1 GeV beam energy (d) a 25 m long undulator (period length 27 mm, peak field 0.5 T) The average brillance will be larger than 1-10{sup 22}photons/s/mm{sup 2}/mrad{sup 2}/0.1%. Each 800 {mu}s long pulse will contain up to 7200 equidistant bunches. The repetition frequency of the linac is 10 Hz.

  18. Transatlantic transport of Fermilab 3.9 GHz cryomodule for TTF/FLASH to DESY

    SciTech Connect

    McGee, M.W.; Vocean, V.; Grimm, C.; Schappert, W.; /Fermilab

    2008-06-01

    In an exchange of technology agreement, Fermilab built and will deliver a 3.9 GHz (3rd harmonic) cryomodule to DESY to be installed in the TTF/FLASH beamline. This cryomodule delivery will involve a combination of flatbed air ride truck and commercial aircraft transport to Hamburg Germany. A description of the isolation and damping systems that maintain alignment during transport and protect fragile components is provided. Initially, transport and corresponding alignment stability studies were performed in order to assess the risk associated with transatlantic travel of a fully assembled cryomodule. Shock loads were applied to the cryomodule by using a coldmass mockup to prevent subjecting actual critical components (such as the cavities and input couplers) to excessive forces. Accumulative and peak shock loads were applied through over-the-road testing and using a pendulum hammer apparatus, respectively. Finite Element Analysis (FEA) studies were implemented to define location of instrumentation for transport studies and provide modal frequencies and shapes. Shock and vibration measurement results of transport studies and stabilization techniques are discussed.

  19. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... identical, similar and related products (21 CFR 310.6). Deferral of requirements is not appropriate for the... in the Federal Register of May 25, 1971 (36 FR 9475). (iii) Certain Insulin Preparations (DESI...

  20. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... identical, similar and related products (21 CFR 310.6). Deferral of requirements is not appropriate for the... in the Federal Register of May 25, 1971 (36 FR 9475). (iii) Certain Insulin Preparations (DESI...

  1. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... identical, similar and related products (21 CFR 310.6). Deferral of requirements is not appropriate for the... in the Federal Register of May 25, 1971 (36 FR 9475). (iii) Certain Insulin Preparations (DESI...

  2. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... identical, similar and related products (21 CFR 310.6). Deferral of requirements is not appropriate for the... in the Federal Register of May 25, 1971 (36 FR 9475). (iii) Certain Insulin Preparations (DESI...

  3. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... identical, similar and related products (21 CFR 310.6). Deferral of requirements is not appropriate for the... in the Federal Register of May 25, 1971 (36 FR 9475). (iii) Certain Insulin Preparations (DESI...

  4. FLASH, the Free-Electron Laser at DESY: Machine Performance and Recent Highlights from User Experiments

    NASA Astrophysics Data System (ADS)

    Wurth, Wilfried

    2010-03-01

    FLASH, the Free-Electron Laser at DESY in Hamburg is a world-wide unique facility delivering intense ultra-short coherent radiation pulses in the wavelength range between 47 and 6.8 nm. FLASH is a high-gain free-electron laser based on a superconducting linear accelerator currently running at 1GeV. Laser amplification and saturation in the so-called SASE (self-amplified spontaneous emission) mode is achieved with a single pass of the electron bunch through a 30m undulator. A machine upgrade which has been started recently will boost the energy to 1.2 GeV expanding the wavelength range to below 5nm. After the upgrade FLASH will also include the seeding experiment sFLASH where an external laser will overlap with the electron beam to seed the SASE process. First beam with the upgraded facility is expected in spring 2010. Since 2005 FLASH has been operating as a user facility serving a large variety of experiments. The unprecedented brilliance of the femtosecond coherent pulses in the extreme ultraviolet (XUV) and soft x-ray regime has been used to study nonlinear process in laser-matter interaction for atoms and molecules, to gain new insights in the properties of matter under extreme conditions and to perform single shot lens-less imaging of nano-sized objects. Furthermore, the pulse duration of less than 30 femtoseconds has allowed to gain new insights in ultrafast dynamics of matter. In the talk I will review machine performance and give examples of highlight experiments.

  5. Lipid dynamics in zebrafish embryonic development observed by DESI-MS imaging and nanoelectrospray-MS.

    PubMed

    Pirro, V; Guffey, S C; Sepúlveda, M S; Mahapatra, C T; Ferreira, C R; Jarmusch, A K; Cooks, R G

    2016-06-01

    The zebrafish Danio rerio is a model vertebrate organism for understanding biological mechanisms. Recent studies have explored using zebrafish as a model for lipid-related diseases, for in vivo fish bioassays, and for embryonic toxicity experiments. Mass spectrometry (MS) and MS imaging are established tools for lipid profiling and spatial mapping of biomolecules and offer rapid, sensitive, and simple analytical protocols for zebrafish analysis. When ambient ionization techniques are used, ions are generated in native environmental conditions, requiring neither sample preparation nor separation of molecules prior to MS. We used two direct MS techniques to describe the dynamics of the lipid profile during zebrafish embryonic development from 0 to 96 hours post-fertilization and to explore these analytical approaches as molecular diagnostic assays. Desorption electrospray ionization (DESI) MS imaging followed by nanoelectrospray (nESI) MS and tandem MS (MS/MS) were used in positive and negative ion modes, allowing the detection of a large variety of phosphatidylglycerols, phosphatidylcholines, phosphatidylinositols, free fatty acids, triacylglycerols, ubiquinone, squalene, and other lipids, and revealed information on the spatial distributions of lipids within the embryo and on lipid molecular structure. Differences were observed in the relative ion abundances of free fatty acids, triacylglycerols, and ubiquinone - essentially localized to the yolk - across developmental stages, whereas no relevant differences were found in the distribution of complex membrane glycerophospholipids, indicating conserved lipid constitution. Embryos exposed to trichloroethylene for 72 hours exhibited an altered lipid profile, indicating the potential utility of this technique for testing the effects of environmental contaminants. PMID:27120110

  6. Inspection of a Spherical Triple VLS-Grating for Self-Seeding of FLASH at DESY

    NASA Astrophysics Data System (ADS)

    Siewert, Frank; Lammert, Heiner; Reichardt, Gerd; Hahn, Ulrich; Treusch, Rolf; Reininger, Ruben

    2007-01-01

    To take benefit from the improved brilliance of the laser-like source, proposed beamlines at Free Electron Lasers (FEL) require optical elements of excellent precision, characterised by slope errors beyond the state of the art limit of 0.5μrad rms for plane and spherical shape. Part of the monochromator beamline for self-seeding at the vacuum-ultraviolet Free Electron Laser (FLASH) at DESY is a triple Variable Line Spacing (VLS) grating of spherical shape. The three grating structures on a common substrate will cover the wavelength range from 6.4 to 60nm The challenging specifications of these grating structures are characterised by a slope error of less than 0.25μrad rms and very stringent parameters for the VLS-polynomial. These grating structures have been measured by use of the Nano Optic Measuring Machine (NOM) at BESSY. Based on the principle of deflectometry the BESSY-NOM represents the latest generation of slope measuring metrology instruments. The NOM enables the inspection of optical components with a measurement uncertainty in the range of 0.05μrad rms. This is a five to tenfold improvement compared to state of the art metrology tools of today. Here it is demonstrated how these outstanding metrology capabilities have been applied for a sound characterisation of a challenging precision optical component with error limits five times below the specifications. In the shown example the grating's figure accuracy has been characterised by linescans and surface mapping measurements of the optical active sections. In additional measurements under Littrow condition the higher order diffraction signals of the laser pencil beam have been traced to measure the groove density variation of the different grating-structures with a lateral resolution of 1mm. In contrast to the sparse and point like measurements of the manufacturer, these high resolution measurements yield a "slope deviation equivalent" resulting from imperfections in the line density variation.

  7. Inspection of a Spherical Triple VLS-Grating for Self-Seeding of FLASH at DESY

    SciTech Connect

    Siewert, Frank; Lammert, Heiner; Reichardt, Gerd; Hahn, Ulrich; Treusch, Rolf; Reininger, Ruben

    2007-01-19

    To take benefit from the improved brilliance of the laser-like source, proposed beamlines at Free Electron Lasers (FEL) require optical elements of excellent precision, characterised by slope errors beyond the state of the art limit of 0.5{mu}rad rms for plane and spherical shape. Part of the monochromator beamline for self-seeding at the vacuum-ultraviolet Free Electron Laser (FLASH) at DESY is a triple Variable Line Spacing (VLS) grating of spherical shape. The three grating structures on a common substrate will cover the wavelength range from 6.4 to 60nm The challenging specifications of these grating structures are characterised by a slope error of less than 0.25{mu}rad rms and very stringent parameters for the VLS-polynomial. These grating structures have been measured by use of the Nano Optic Measuring Machine (NOM) at BESSY. Based on the principle of deflectometry the BESSY-NOM represents the latest generation of slope measuring metrology instruments. The NOM enables the inspection of optical components with a measurement uncertainty in the range of 0.05{mu}rad rms. This is a five to tenfold improvement compared to state of the art metrology tools of today. Here it is demonstrated how these outstanding metrology capabilities have been applied for a sound characterisation of a challenging precision optical component with error limits five times below the specifications. In the shown example the grating's figure accuracy has been characterised by linescans and surface mapping measurements of the optical active sections. In additional measurements under Littrow condition the higher order diffraction signals of the laser pencil beam have been traced to measure the groove density variation of the different grating-structures with a lateral resolution of 1mm. In contrast to the sparse and point like measurements of the manufacturer, these high resolution measurements yield a 'slope deviation equivalent' resulting from imperfections in the line density variation.

  8. "Loops and Legs in Quantum Field Theory", 12th DESY Workshop on Elementary Particle Physics

    NASA Astrophysics Data System (ADS)

    excellent working conditions. We would like to thank Martina Mende for all her work in helping to organize this conference. Details of the conference can be found under: https://indico.desy.de/conferenceDisplay.py?confId=8107

  9. Seasonal prevalence of gastrointestinal parasites in desi fowl (Gallus gallus domesticus) in and around Gannavaram, Andhra Pradesh.

    PubMed

    Sreedevi, C; Jyothisree, Ch; Rama Devi, V; Annapurna, P; Jeyabal, L

    2016-09-01

    A study was carried out to know the prevalence of gastrointestinal parasites in desi fowl in and nearby villages of Gannavaram, Andhra Pradesh for a period of 1 year. Screening of 492 samples comprising faecal samples and gastrointestinal tracts from freshly slaughtered desi birds at local poultry shops and samples from post mortem examinations at NTR College of Veterinary Science, Gannavaram revealed 63.21 % of gastrointestinal parasites. Faecal samples were examined by floatation technique using salt solution and samples positive for coccidian oocysts were sporulated in 2.5 % potassium dichromate solution for species identification. Adult worms were identified after routine processing and mounting. The species identified includes Davainea proglottina, Raillietina cesticillus and Raillietina echinobothrida in cestodes (32.47 %), Ascaridia galli, Capillaria annulata, Heterakis gallinarum in nematodes (39.87 %), Eimeria tenella, Eimeria acervulina and Eimeria necatrix in Eimeria spp. (39.87 %). Ascaridia galli and R. cesticillus and A. galli and Eimeria spp. were common in mixed infection (12.86 %). Ascaridia galli was the more prevalent species. No trematode parasite was identified during the study period. Significant (p = 0.001) relationship between the seasonality and prevalence of gastrointestinal parasites was observed (χ2 = 17.46, df = 2). Data revealed high prevalence in rainy season (43.41 %) followed by summer (38.91 %) and winter (17.68 %) seasons for all parasites except for A. galli and C. annulata infections which were higher in summer season. Results indicated high prevalence of gastrointestinal parasites in desi fowl in study area emphasizing the need of improved management practices of backyard poultry. PMID:27605762

  10. DESI-MS2: a rapid and innovative method for trace analysis of six cytostatic drugs in health care setting.

    PubMed

    Fabrizi, Giovanni; Fioretti, Marzia; Rocca, Lucia Mainero; Curini, Roberta

    2012-05-01

    With the aim of establishing exposure levels for hospital personnel preparing and administering cytostatic drugs (CDs), here, we present an innovative screening method based on the use of the desorption electrospray ionization (DESI) interface coupled with a hybrid quadrupole linear ion trap mass spectrometer. A rapid, simple, and sensitive procedure was developed for the simultaneous surface monitoring of cyclophosphamide, dacarbazine, methotrexate, vincristine, gemcitabine, and cytarabine. Since analytes were in the solid state, a novel approach based on the use of passive samplers was combined with the direct analysis of wipes. A PTFE-printed glass slide was used as a passive sampler, while hydrophobic centers of Swiffer® cloths were judged extremely efficient as wipe samplers. After the sampling period, the CD collectors were directly processed with the DESI-MS system without any further treatment. MS/MS confirmatory analysis was conducted using selected reaction monitoring in the positive ion mode and detection limits were evaluated. Values were at the picograms per square millimeter levels on the passive collector and at the picograms per square centimeter levels for the wipe ones. Direct determination on solid-state samples combined with mass spectrometry selectivity provided a powerful tool so far unapplied to occupational hygiene. PMID:22200922

  11. Wie wissenschaftlich ist der Evolutionsgedanke?

    NASA Astrophysics Data System (ADS)

    Vollmer, Gerhard

    Darwin war ein besonnener Mann; alles Aufsehen war ihm zuwider. Trotzdem hat er eine Revolution ausgelöst, deren Wirkung nicht auf die Biologie beschränkt blieb. Seine Theorie lässt sich in fünf Teiltheorien zerlegen, die sich durch die Begriffe Artenwandel, Verwandtschaft alles Lebendigen und gemeinsamer Ursprung, Artenaufspaltung und Artenvielfalt, Gradualismus, natürliche Auslese charakterisieren lassen. Dadurch wurden mehrere religiöse und weitere weltanschauliche Überzeugungen in Frage gestellt. Deshalb wird die Evolutionstheorie auch heute noch vielfach kritisiert, ja bekämpft. Die Vorwürfe lassen sich ordnen nach den Kriterien, mit denen wir erfahrungswissenschaftliche Theorien beurteilen. Haltbar ist daran nur, dass es für die Evolutionstheorie zwar beliebig viele Bestätigungen gibt, aber nur wenige Widerlegungsmöglichkeiten. Durch die neuerdings entwickelten und durchgeführten Evolutionsexperimente ist die empirische Situation allerdings deutlich besser geworden. Am (erfahrungs)wissenschaftlichen Charakter der Evolutionstheorie besteht deshalb kein Zweifel.

  12. Desorption Electrospray Ionization (DESI) Mass Spectrometric Imaging of the Distribution of Rohitukine in the Seedling of Dysoxylum binectariferum Hook. F

    PubMed Central

    Mohana Kumara, Patel; Srimany, Amitava; Arunan, Suganya; Ravikanth, Gudasalamani; Uma Shaanker, Ramanan; Pradeep, Thalappil

    2016-01-01

    Ambient ionization mass spectrometric imaging of all parts of the seedling of Dysoxylum binectariferum Hook. f (Meliaceae) was performed to reconstruct the molecular distribution of rohitukine (Rh) and related compounds. The species accumulates Rh, a prominent chromone alkaloid, in its seeds, fruits, and stem bark. Rh possesses anti-inflammatory, anti-cancer, and immuno-modulatory properties. Desorption electrospray ionization mass spectrometry imaging (DESI MSI) and electrospray ionization (ESI) tandem mass spectrometry (MS/MS) analysis detected Rh as well as its glycosylated, acetylated, oxidized, and methoxylated analogues. Rh was predominantly distributed in the main roots, collar region of the stem, and young leaves. In the stem and roots, Rh was primarily restricted to the cortex region. The identities of the metabolites were assigned based on both the fragmentation patterns and exact mass analyses. We discuss these results, with specific reference to the possible pathways of Rh biosynthesis and translocation during seedling development in D. binectariferum. PMID:27362422

  13. Development and validation of a DESI-HRMS/MS method for the fast profiling of esomeprazole and its metabolites in rat plasma: a pharmacokinetic study.

    PubMed

    Rossi, Alessandra; Castrati, Luca; Colombo, Paolo; Flammini, Lisa; Barocelli, Elisabetta; Bettini, Ruggero; Elviri, Lisa

    2016-02-01

    The advances in pharmaceutical development and drug discovery impose the availability of reliable high-throughput screening methods for the rapid evaluation of drug metabolism and pharmacokinetic (PK) in biological samples. Here, a desorption electrospray mass spectrometry (DESI-MS) method has been developed and validated for the PK profiling of esomeprazole and its metabolites (5-hydroxyomeprazole and omeprazole sulfone) in rat plasma. Rats were treated with an esomeprazole solution (2.5 mg/mL) for endovenous administration and the analyte levels were profiled over 2 h after liquid-liquid extraction from plasma. MS and tandem mass spectrometry (MS/MS) experiments were performed by using a DESI-LTQ-Orbitrap XL instrument and an on-spot fixed time analysis on PMMA surfaces. Validation was performed for the esomeprazole. The DESI-MS/MS method exhibited for the esomepazole excellent sensitivity (limit of detection (LOD)=60 ng/mL), linearity (0.2-20 µg/mL concentration range; y=23848(±361)X, n=15; r(2) =0.987) and precision (RSD<9%) by using an internal standard method. The PK results were discussed in terms of Area Under the Curve, Cmax and Tmax . Data reliability was demonstrated by comparison with a liquid chromatography-tandem mass spectrometry method (p>0.05). The data achieved demonstrated that the DESI-MS method is suitable for sensitive and fast profiling of a drug and its metabolites at the therapeutic concentration levels. PMID:25922056

  14. Trace detection of non-uniformly distributed analytes on surfaces using mass transfer and large-area desorption electrospray ionization (DESI) mass spectrometry.

    PubMed

    Soparawalla, Santosh; Salazar, Gary A; Sokol, Ewa; Perry, Richard H; Cooks, R Graham

    2010-08-01

    Ambient ionization methods such as desorption electrospray ionization (DESI) allow the analysis of chemicals adsorbed at surfaces without the need for sample (or surface) pretreatment. A limitation of current implementations of these ionization sources is the small size of the area that can be sampled. This makes examination of surfaces of large areas time-consuming because of the need to raster across the surface. This paper describes a DESI source that produces a spray plume with an effective desorption/ionization area of 3.6 cm(2), some 200 times larger than given by conventional DESI sources. Rhodamine 6G and several drugs of abuse (codeine, heroin and diazepam) were used to demonstrate the ability to use large-area DESI MS to perform rapid (a few seconds) representative sampling of areas of the order of several square centimetres without scanning the probe across the surface. The large area ion source displayed high sensitivity (limits of detection in the high nanogram range) and high reproducibility (approximately 20 to 35% relative standard deviation). The rapid analysis of even larger surfaces (hundreds of cm(2)) for traces of explosives is possible using a sorbent surface wipe followed by large-area DESI interrogation performed directly on the wipe material. The performance of this mass transfer dry wipe method was examined by determination of the limits of detection of several explosives. Surfaces with different topographies and compositions were also tested. Using this method, absolute limits of detection observed for HMX and RDX from plastic surfaces and skin were found to be as low as 10 ng cm(-2). The concentration of residue from large surface areas in this technique allowed the detection of 100 ng of explosives from surfaces with areas ranging from 1.00 x 10(3) cm(2) to 1.40 x 10(4) cm(2). PMID:20539884

  15. Design considerations and analysis of potential applications of a high power ultraviolet FEL at the TESLA test facility at DESY

    NASA Astrophysics Data System (ADS)

    Pagani, C.; Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

    1999-02-01

    A possibility of constructing a high power ultraviolet free electron laser at the TESLA test facility at DESY is discussed. The proposed facility consists of a tunable master oscillator (P av˜10 mW, P peak˜10 kW, λ≃200-350 nm) and an FEL amplifier with a tapered undulator. The average and peak radiation power at the exit of the FEL amplifier is about 7 kW and 220 GW, respectively. Installation of such a facility can significantly extend scientific potential of the TESLA test facility. The UV free electron laser can be used to construct a polarized, monochromatic gamma-source with the ultimate yield up to 10 12 gamma-quanta per second and the maximal energy of about 100 MeV. An intensive gamma-source can also form the base for constructing the test facility for the TESLA positron generation system. Another accelerator application of the proposed facility is verification of the main technical solutions for the laser and the optical system to be used in the gamma-gamma option of the TESLA collider. A high average power UV laser is also promising for industrial applications.

  16. Search for resonance decays to a ν¯ plus jet in e+p scattering at DESY HERA

    NASA Astrophysics Data System (ADS)

    Breitweg, J.; Chekanov, S.; Derrick, M.; Krakauer, D.; Magill, S.; Musgrave, B.; Pellegrino, A.; Repond, J.; Stanek, R.; Yoshida, R.; Mattingly, M. C.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Romeo, G. Cara; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; de Pasquale, S.; Giusti, P.; Iacobucci, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Palmonari, F.; Pesci, A.; Sartorelli, G.; Zichichi, A.; Amelung, C.; Bornheim, A.; Brock, I.; Coböken, K.; Crittenden, J.; Deffner, R.; Hartmann, H.; Heinloth, K.; Hilger, E.; Irrgang, P.; Jakob, H.-P.; Kappes, A.; Katz, U. F.; Kerger, R.; Paul, E.; Rautenberg, J.; Schnurbusch, H.; Stifutkin, A.; Tandler, J.; Voss, K. C.; Weber, A.; Wieber, H.; Bailey, D. S.; Barret, O.; Brook, N. H.; Foster, B.; Heath, G. P.; Heath, H. F.; Rodrigues, E.; Scott, J.; Tapper, R. J.; Capua, M.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Jeoung, H. Y.; Kim, J. Y.; Lee, J. H.; Lim, I. T.; Ma, K. J.; Pac, M. Y.; Caldwell, A.; Liu, W.; Liu, X.; Mellado, B.; Paganis, S.; Sampson, S.; Schmidke, W. B.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Klimek, K.; Olkiewicz, K.; Piotrzkowski, K.; Przybycień, M. B.; Stopa, P.; Zawiejski, L.; Bednarek, B.; Jeleń, K.; Kisielewska, D.; Kowal, A. M.; Kowalski, T.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Szuba, D.; Kotański, A.; Bauerdick, L. A.; Behrens, U.; Bienlein, J. K.; Borras, K.; Chiochia, V.; Dannheim, D.; Desler, K.; Drews, G.; Fox-Murphy, A.; Fricke, U.; Goebel, F.; Goers, S.; Göttlicher, P.; Graciani, R.; Haas, T.; Hain, W.; Hartner, G. F.; Hasell, D.; Hebbel, K.; Hillert, S.; Kasemann, M.; Koch, W.; Kötz, U.; Kowalski, H.; Labes, H.; Lindemann, L.; Löhr, B.; Mankel, R.; Martens, J.; Martínez, M.; Milite, M.; Moritz, M.; Notz, D.; Petrucci, M. C.; Polini, A.; Rohde, M.; Savin, A. A.; Schneekloth, U.; Selonke, F.; Sievers, M.; Stonjek, S.; Wolf, G.; Wollmer, U.; Youngman, C.; Zeuner, W.; Coldewey, C.; Lopez-Duran Viani, A.; Meyer, A.; Schlenstedt, S.; Straub, P. B.; Barbagli, G.; Gallo, E.; Parenti, A.; Pelfer, P. G.; Bamberger, A.; Benen, A.; Coppola, N.; Eisenhardt, S.; Markun, P.; Raach, H.; Wölfle, S.; Bussey, P. J.; Bell, M.; Doyle, A. T.; Glasman, C.; Lee, S. W.; Lupi, A.; MacDonald, N.; McCance, G. J.; Saxon, D. H.; Sinclair, L. E.; Skillicorn, I. O.; Waugh, R.; Bohnet, I.; Gendner, N.; Holm, U.; Meyer-Larsen, A.; Salehi, H.; Wick, K.; Carli, T.; Garfagnini, A.; Gialas, I.; Gladilin, L. K.; Kçira, D.; Klanner, R.; Lohrmann, E.; Gonçalo, R.; Long, K. R.; Miller, D. B.; Tapper, A. D.; Walker, R.; Mallik, U.; Cloth, P.; Filges, D.; Ishii, T.; Kuze, M.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Ahn, S. H.; Lee, S. B.; Park, S. K.; Lim, H.; Park, I. H.; Son, D.; Barreiro, F.; García, G.; González, O.; Labarga, L.; del Peso, J.; Redondo, I.; Terrón, J.; Vázquez, M.; Barbi, M.; Corriveau, F.; Hanna, D. S.; Ochs, A.; Padhi, S.; Stairs, D. G.; Wing, M.; Tsurugai, T.; Antonov, A.; Bashkirov, V.; Danilov, M.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Golubkov, Yu. A.; Katkov, I. I.; Khein, L. A.; Korotkova, N. A.; Korzhavina, I. A.; Kuzmin, V. A.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Solomin, A. N.; Vlasov, N. N.; Zotkin, S. A.; Bokel, C.; Botje, M.; Brümmer, N.; Engelen, J.; Grijpink, S.; Koffeman, E.; Kooijman, P.; Schagen, S.; van Sighem, A.; Tassi, E.; Tiecke, H.; Tuning, N.; Velthuis, J. J.; Vossebeld, J.; Wiggers, L.; de Wolf, E.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Ginsburg, C. M.; Kim, C. L.; Ling, T. Y.; Boogert, S.; Cooper-Sarkar, A. M.; Devenish, R. C.; Große-Knetter, J.; Matsushita, T.; Ruske, O.; Sutton, M. R.; Walczak, R.; Bertolin, A.; Brugnera, R.; Carlin, R.; dal Corso, F.; Dosselli, U.; Dusini, S.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Turcato, M.; Voci, C.; Adamczyk, L.; Iannotti, L.; Oh, B. Y.; Okrasiński, J. R.; Saull, P. R.; Toothacker, W. S.; Whitmore, J. J.; Iga, Y.; D'agostini, G.; Marini, G.; Nigro, A.; Cormack, C.; Hart, J. C.; McCubbin, N. A.; Shah, T. P.; Epperson, D.; Heusch, C.; Sadrozinski, H. F.-W.; Seiden, A.; Wichmann, R.; Williams, D. C.; Pavel, N.; Abramowicz, H.; Dagan, S.; Kananov, S.; Kreisel, A.; Levy, A.; Abe, T.; Fusayasu, T.; Umemori, K.; Yamashita, T.; Hamatsu, R.; Hirose, T.; Inuzuka, M.; Kitamura, S.; Nishimura, T.; Arneodo, M.; Cartiglia, N.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Monaco, V.; Peroni, C.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Bailey, D. C.; Fagerstroem, C.-P.; Galea, R.; Koop, T.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Polenz, S.; Sabetfakhri, A.; Simmons, D.; Butterworth, J. M.; Hayes, M. E.; Heaphy, E. A.; Jones, T. W.; Lane, J. B.; West, B. J.; Ciborowski, J.; Ciesielski, R.; Grzelak, G.; Nowak, R. J.; Pawlak, J. M.; Pawlak, R.; Smalska, B.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Gadaj, T.; Deppe, O.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Badgett, W. F.; Chapin, D.; Cross, R.; Foudas, C.; Mattingly, S.; Reeder, D. D.; Smith, W. H.; Vaiciulis, A.; Wildschek, T.; Wodarczyk, M.; Deshpande, A.; Dhawan, S.; Hughes, V. W.; Bhadra, S.; Catterall, C.; Cole, J. E.; Frisken, W. R.; Hall-Wilton, R.; Khakzad, M.; Menary, S.

    2001-03-01

    A study of the ν¯-jet mass spectrum in e+p-->ν¯X events at a center-of-mass energy 300 GeV has been performed with the ZEUS detector at the HERA collider at DESY using an integrated luminosity of 47.7 pb-1. The mass spectrum is in good agreement with that expected from standard model processes over the ν¯-jet mass range studied. No significant excess attributable to the decay of a narrow resonance is observed. By using both e+p-->e+X and e+p-->ν¯X data, mass-dependent limits are set on the s-channel production of scalar and vector resonant states. Couplings to first-generation quarks are considered and limits are presented as a function of the e+q and ν¯q branching ratios. These limits are used to constrain the production of leptoquarks and R-parity violating squarks.

  17. Electrospun Nanofiber Mats as "Smart Surfaces" for Desorption Electrospray Ionization Mass Spectrometry (DESI MS)-Based Analysis and Imprint Imaging.

    PubMed

    Hemalatha, R G; Ganayee, Mohd Azhardin; Pradeep, T

    2016-06-01

    In this paper, desorption electrospray ionization mass spectrometry (DESI MS)-based molecular analysis and imprint imaging using electrospun nylon-6 nanofiber mats are demonstrated for various analytical contexts. Uniform mats of varying thicknesses composed of ∼200 nm diameter fibers were prepared using needleless electrospinning. Analytical applications requiring rapid understanding of the analytes in single drops, dyes, inks, and/or plant extracts incorporated directly into the nanofibers are discussed with illustrations. The possibility to imprint patterns made of printing inks, plant parts (such as petals, leaves, and slices of rhizomes), and fungal growth on fruits with their faithful reproductions on the nanofiber mats is illustrated with suitable examples. Metabolites were identified by tandem mass spectrometry data available in the literature and in databases. The results highlight the significance of electrospun nanofiber mats as smart surfaces to capture diverse classes of compounds for rapid detection or to imprint imaging under ambient conditions. Large surface area, appropriate chemical functionalities exposed, and easiness of desorption due to weaker interactions of the analyte species are the specific advantages of nanofibers for this application. PMID:27159150

  18. Simulations of laser-wakefield acceleration with external electron-bunch injection for REGAE experiments at DESY

    SciTech Connect

    Grebenyuk, Julia; Mehrling, Timon; Tsung, Frank S.; Floettman, Klaus; Osterhoff, Jens

    2012-12-21

    We present particle-in-cell simulations for future laser-plasma wakefield experiments with external bunch injection at the REGAE accelerator facility at DESY, Hamburg, Germany. Two effects have been studied in detail: emittance evolution of electron bunches externally injected into a wake, and longitudinal bunch compression inside the wakefield. Results show significant transverse emittance growth during the injection process, if the electron bunch is not matched to its intrinsic betatron motion inside the wakefield. This might introduce the necessity to include beam-matching sections upstream of each plasma-accelerator section with fundamental implications on the design of staged laser wakefield accelerators. When externally injected at the zero-field crossing of the laser-driven wake, the electron bunch may undergo significant compression in longitudinal direction and be accelerated simultaneously due to the gradient in the acting force. The mechanism would allow for production of single high-energy, ultra-short (on the order of one femtosecond) bunches at REGAE. The optimal conditions for maximal bunch compression are discussed in the presented studies.

  19. The Extreme Conditions Beamline at PETRA III, DESY: Possibilities to conduct time resolved monochromatic diffraction experiments in dynamic and laser heated DAC

    NASA Astrophysics Data System (ADS)

    Liermann, H.-P.; Morgenroth, W.; Ehnes, A.; Berghäuser, A.; Winkler, B.; Franz, H.; Weckert, E.

    2010-03-01

    We present plans for the new Extreme Conditions Beamline at PETRA III, DESY, Germany. The beamline is being designed and built with the specific goal to explore time resolved high-pressure and -temperature x-ray diffraction experiments in the dynamic and laser heated diamond anvil cell. Within we discuss the conceptual design of the optical components and experimental setup to conduct monochromatic high-pressure powder diffraction experiments in the sub-second time regime.

  20. Tuning of 2.998 GHz S-band hybrid buncher for injector upgrade of LINAC II at DESY

    NASA Astrophysics Data System (ADS)

    Nie, Y. C.; Liebig, C.; Hüning, M.; Schmitz, M.

    2014-10-01

    The injector upgrade of LINAC II at DESY aims to improve its reliability and mitigate the radiological activation of components due to electron loss at relatively high energy of hundreds of MeV. Therefore, a 2.998 GHz hybrid buncher has been developed and will be installed in between an existing 2.998 GHz pre-buncher and LINAC II. It comprises a 1-cell standing-wave (SW) section for rapid electron acceleration and a 13-cells traveling-wave (TW) section for further beam bunching and acceleration. This paper focuses on its radio-frequency tuning procedure. The tuning strategy combines a non-resonant bead-pull measurement of complex electric field and a linear model for local reflection coefficient calculation. It is demonstrated that imaginary part of the local reflection coefficient represents the field distribution straightforwardly, based on which the structure can be tuned from cell to cell. During tuning, special attention has been paid to the field enhancement in the SW section to ensure its beam-capturing capability. Field amplitude and phase, global and local reflection coefficients have been analyzed for two different frequencies simultaneously, i.e. the intrinsic frequency of the structure and the target frequency, to avoid over-tuning. The tuning result is satisfying. For the target frequency, field unflatness of the TW section has been reduced from ±9% to ±4%, and field in the SW section has been enhanced significantly. Meanwhile, in the TW section, the deviation of phase advances between adjacent cells from the nominal value 120° has been reduced from the range ±5° to ±2°. By using ASTRA simulation, it has been verified that the residual detuning of the structure is acceptable in view of the beam dynamics performance.

  1. Free-electron laser at the TESLA Test Facility at DESY: toward a tunable short-pulsed soft x-ray source

    NASA Astrophysics Data System (ADS)

    Gerth, Christopher

    2001-12-01

    A high peak current, low emittance, short pulse electron beam can produce intense, laser-like radiation in a single pass through a long periodic magnetic structure. The construction of such free-electron lasers (FELs) based on self-amplified spontaneous emission (SASE) has become feasible by recent advances in accelerator technologies. Since SASE FELs do not require any optical components they are promising sources for the generation of intense, sub- picosecond laser pulses which are continuously tunable over a wide wavelength range in the vacuum ultraviolet (VUV) and X-ray region. In the first phase of the VUV-FEL (phase I) at the TESLA Test Facility at DESY, SASE was achieved for the first time in the VUV at wavelengths between 80 and 180 nm. The concept of the VUV FEL at DESY and first experimental results are presented. The second phase of the TESLA Test Facility (phase II), which includes an increase of the electron beam energy to 1 GeV, aims at the construction of a SASE FEL operating in the soft X-ray region. An overview of the current status and the activities toward a soft X-ray FEL user facility is given.

  2. Use of intermediate focus for grazing incidence small and wide angle x-ray scattering experiments at the beamline P03 of PETRA III, DESY

    SciTech Connect

    Santoro, G.; Buffet, A.; Döhrmann, R.; Yu, S.; Roth, S. V.; Körstgens, V.; Müller-Buschbaum, P.; Gedde, U.; Hedenqvist, M.

    2014-04-15

    We describe the new experimental possibilities of the micro- and nanofocus X-ray scattering beamline P03 of the synchrotron source PETRA III at DESY, Hamburg (Germany), which arise from experiments with smaller beam sizes in the micrometer range. This beamline has been upgraded recently to perform new kinds of experiments. The use of an intermediate focus allows for reducing the beam size of microfocused hard X-rays while preserving a large working distance between the focusing elements and the focus position. For the first time, this well-known methodology has been employed to grazing incidence small- and wide-angle X-ray scattering (GISAXS/GIWAXS). As examples, we highlight the applications to in situ studies using microfluidic devices in GISAXS geometry as well as the investigation of the crystallinity of thin films in GIWAXS geometry.

  3. Probing Molecular Associations of Secondary Organic Aerosol (SOA) Samples from CalNex 2010 with Nano-DESI High-Resolution Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    O'Brien, R. E.; Nguyen, T. B.; Laskin, A.; Laskin, J.; Hayes, P. L.; Liu, S.; Jimenez, J. L.; Russell, L. M.; Nizkorodov, S.; Goldstein, A. H.

    2012-12-01

    This project focuses on analyzing the identities of molecules that comprise oligomers in size resolved aerosol fractions. Since oligomers are generally too large and polar to be measured by typical GC/MS analysis, soft ionization with high resolution mass spectrometry is used to extend the range of observable compounds. Samples collected during CalNex 2010 in Bakersfield and Los Angeles and secondary organic aerosol (SOA) produced in a photochemical chamber by photooxidation of diesel (DSL) fuel and isoprene (ISO) under humid, high-NOx conditions have been analyzed with nanospray desorption electrospray ionization (nano-DESI) and a high-resolution Orbitrap mass spectrometer. The nano-DESI is a soft ionization technique that allows molecular ions to be observed and the Orbitrap has sufficient resolution to determine the elemental composition of almost all species above the detection limit. A large fraction of SOA is made up of high molecular weight oligomers which are thought to form through acid catalyzed reactions of photo-chemically processed volatile organic compounds (VOC). The formation of oligomers is influenced by the VOCs available, the amount of atmospheric sulfate and nitrate, and the magnitude of photo-chemical processing, among other potential influences. We present the elemental composition of chemical species in size resolved SOA samples with six-hour time resolution, providing the first time resolved data set for the study of these oligomers in atmospheric samples. We present a comparison of the degree of overlap between the ambient and chamber experiments as a novel method to examine sources for this fraction of SOA. Possible formation pathways and sources of observed compounds are analyzed by comparison to other concurrent measurements at the site.

  4. High Throughput Screening of High-Affinity Ligands for Proteins with Anion-Binding Sites using Desorption Electrospray Ionization (DESI) Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Lu, Xin; Ning, Baoming; He, Dacheng; Huang, Lingyun; Yue, Xiangjun; Zhang, Qiming; Huang, Haiwei; Liu, Yang; He, Lan; Ouyang, Jin

    2014-03-01

    A high throughput screening system involving a linear ion trap (LTQ) analyzer, a house-made platform and a desorption electrospray ionization (DESI) source was established to screen ligands with a high affinity for proteins with anion-binding sites. The complexes were analyzed after incubation, ultrafiltration, washing, and displacement. A new anionic region inhibited dissociation (ARID) mechanism that was suitable for a protein with anion-binding site was proposed. We utilized the differences in detectable dissociation of protein-ligand complexes, combined with displacement experiments, to distinguish free ligands displaced from anion-binding sites from liberated ligands dissociated from nonspecific interactions. The method was validated by α1-acid glycoprotein (AGP) and (R), (S)-amlodipine. Site-specific enantioselectivity shown in our experiments was consistent with earlier studies. Obtaining all of the qualitative information of 15*3 samples in 2.3 min indicates that the analysis process is no longer the time-limiting step in the initial stage of drug discovery. Quantitative information verified that our method was at least a semiquantitative method.

  5. Probing Molecular Associations of Field-Collected and Laboratory-Generated SOA with Nano-DESI High-Resolution Mass Spectrometry

    SciTech Connect

    O'Brien, Rachel E.; Nguyen, Tran B.; Laskin, Alexander; Laskin, Julia; Hayes, Patrick L.; Liu, Shang; Jimenez, Jose L.; Russell, Lynn M.; Nizkorodov, Sergey; Goldstein, Allen H.

    2013-01-30

    Aerosol samples from the 2010 CalNex field study in Bakersfield (BF) and Los Angeles (LA) were analyzed using positive mode nanospray-desorption electrospray ionization mass spectrometry (nano-DESI-MS). Secondary organic aerosol (SOA) produced in a photochemical chamber by photooxidation of diesel (DSL) fuel and isoprene (ISO) under humid, high-NOx conditions, was analyzed for comparison. Three groups of organic compounds with zero, one, or two nitrogen atoms in their molecular formulas (0N, 1N, 2N) were compared in detail. The composition of ambient SOA exhibited greater overlap with DSL than with ISO. The overlap of the chamber experiments with the BF data was relatively consistent throughout the day while the overlap with LA data increased significantly in the noon-6pm sample, consistent with the SOA plume arriving from downtown Los Angeles. BF samples were more oxidized, contained more organic nitrogen, and had more overlap with the chamber data compared to LA samples. The addition of gaseous ammonia (NH3) to the DSL experiment was necessary to generate many of the 2N compounds observed in BF. This analysis demonstrates that DSL and ISO were important sources but cannot account for all of the observed ambient compounds indicating that other sources of organics were also likely important.

  6. Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY)

    PubMed Central

    Blanchet, Clement E.; Spilotros, Alessandro; Schwemmer, Frank; Graewert, Melissa A.; Kikhney, Alexey; Jeffries, Cy M.; Franke, Daniel; Mark, Daniel; Zengerle, Roland; Cipriani, Florent; Fiedler, Stefan; Roessle, Manfred; Svergun, Dmitri I.

    2015-01-01

    A high-brilliance synchrotron P12 beamline of the EMBL located at the PETRA III storage ring (DESY, Hamburg) is dedicated to biological small-angle X-ray scattering (SAXS) and has been designed and optimized for scattering experiments on macromolecular solutions. Scatterless slits reduce the parasitic scattering, a custom-designed miniature active beamstop ensures accurate data normalization and the photon-counting PILATUS 2M detector enables the background-free detection of weak scattering signals. The high flux and small beam size allow for rapid experiments with exposure time down to 30–50 ms covering the resolution range from about 300 to 0.5 nm. P12 possesses a versatile and flexible sample environment system that caters for the diverse experimental needs required to study macromolecular solutions. These include an in-vacuum capillary mode for standard batch sample analyses with robotic sample delivery and for continuous-flow in-line sample purification and characterization, as well as an in-air capillary time-resolved stopped-flow setup. A novel microfluidic centrifugal mixing device (SAXS disc) is developed for a high-throughput screening mode using sub-microlitre sample volumes. Automation is a key feature of P12; it is controlled by a beamline meta server, which coordinates and schedules experiments from either standard or nonstandard operational setups. The integrated SASFLOW pipeline automatically checks for consistency, and processes and analyses the data, providing near real-time assessments of overall parameters and the generation of low-resolution models within minutes of data collection. These advances, combined with a remote access option, allow for rapid high-throughput analysis, as well as time-resolved and screening experiments for novice and expert biological SAXS users. PMID:25844078

  7. Capabilities of the Extreme Conditions Beamline at PETRA III, DESY

    NASA Astrophysics Data System (ADS)

    Liermann, Hanns-Peter; Konôpková, Zuzana; Morgenroth, Wolfgang; Rothkirch, Andre; Wittich, Eugen; Delitz, Jan-Torben; Ehnes, Anita

    2013-06-01

    At the end of 2010 the Extreme Conditions Beamline (ECB) at PETRA III received first beam and entered the commissioning phase. Since 2012 we are offering beamtime to general users to conduct a variety of different experiments such as powder and single diffraction in the laser/resistive heated and cryogenically cooled Diamond Anvil Cell (DAC). Particularly attractive has been our ability to conducted diffraction experiments at high energies of 60 and 77 keV for pair distribution function (PDF) studies as well as possibility to preform time resolved powder diffraction experiments at 26 and 43 keV with a maximum time resolution of 15 Hz. Within we present some of the current capabilities of the beamline as well as future plans to promote single crystal diffraction at high pressures and temperatures using both monochromatic and pink beam. Finally, we emphasis the present and future time resolved capabilities to conduct powder and single crystal diffraction experiments under dynamic compression and heating conditions in the DAC. Part of this project was funded by the ``Bundesministerium fuer Bildung und Forschung'' under contracts 05KS7RF1 and 05K10RFA ``Verbundprojekt: Messeinrichtungen fuer die Material- und Strukturforschung an PETRA III, 2: Laserheizung for ``ECB''.

  8. DESI-MS Analysis of Mycotoxins from Grain Matrices

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Introduction – Determination of mycotoxins in grain matrices is a frequent need of growers and processors of cereal grains. Sample preparation for mycotoxin analysis is often laborious and time consuming. Here we demonstrate the application of desorption electrospray ionization – mass spectrometry...

  9. Hostile Times: Desi College Students Cope with Hate

    ERIC Educational Resources Information Center

    Isler, Hilal Nakiboglu

    2006-01-01

    The attacks of terror carried out on September 11, 2001 gave rise to waves of hate-fueled violence across the country. It has been argued that the attacks and the subsequent, current context of war have resulted in a heightened sense of American intolerance. They have led to discernable shifts in how certain minorities are perceived and treated in…

  10. Lifelong Learning in the Information Age: Organizing Net-Based Learning and Teaching Systems. Wissenschaftliche Fachbibliothek.

    ERIC Educational Resources Information Center

    Finke, Wolfgang F.

    This book examines lifelong learning in the Information Age and the role of higher education (HE) in providing the educational services needed by lifelong learners. The following are among the topics discussed in the book's eight chapters: (1) changes in HE (repercussions of globalization in the educational sector; competition in higher learning;…

  11. Deep exclusive electroproduction of π+ from data measured with the HERMES detector at DESY

    NASA Astrophysics Data System (ADS)

    Kaskulov, Murat M.; Mosel, Ulrich

    2009-08-01

    Deeply virtual electroproduction of pions in an exclusive reaction p(e,e'π+)n is studied using a two-component model that includes soft hadronic and hard partonic reaction mechanisms. The results are compared with the experimental data measured at HERMES in the deep inelastic region for values of Q2>1GeV2 and W2>10GeV2. At forward angles the π+ cross section is longitudinal and is dominated by exchange of Regge poles, with π being the dominant trajectory. The off-forward region with -t>1GeV2 is transverse and shows the dominance of partonic subprocesses. An implication of the present results for the future JLab facilities is briefly discussed.

  12. Search for lepton-flavor violation in e+p collisions at DESY HERA

    NASA Astrophysics Data System (ADS)

    Chekanov, S.; Derrick, M.; Krakauer, D.; Magill, S.; Musgrave, B.; Pellegrino, A.; Repond, J.; Yoshida, R.; Mattingly, M. C.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cara Romeo, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; de Pasquale, S.; Giusti, P.; Iacobucci, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Palmonari, F.; Pesci, A.; Sartorelli, G.; Zichichi, A.; Aghuzumtsyan, G.; Bartsch, D.; Brock, I.; Crittenden, J.; Goers, S.; Hartmann, H.; Hilger, E.; Irrgang, P.; Jakob, H.-P.; Kappes, A.; Katz, U. F.; Kerger, R.; Kind, O.; Paul, E.; Rautenberg, J.; Renner, R.; Schnurbusch, H.; Stifutkin, A.; Tandler, J.; Voss, K. C.; Weber, A.; Wessoleck, H.; Bailey, D. S.; Brook, N. H.; Cole, J. E.; Foster, B.; Heath, G. P.; Heath, H. F.; Robins, S.; Rodrigues, E.; Scott, J.; Tapper, R. J.; Wing, M.; Capua, M.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Jeoung, H. Y.; Kim, J. Y.; Lee, J. H.; Lim, I. T.; Ma, K. J.; Pac, M. Y.; Caldwell, A.; Helbich, M.; Liu, X.; Mellado, B.; Paganis, S.; Schmidke, W. B.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Olkiewicz, K.; Przybycień, M. B.; Stopa, P.; Zawiejski, L.; Bednarek, B.; Grabowska-Bold, I.; Jeleń, K.; Kisielewska, D.; Kowal, A. M.; Kowal, M.; Kowalski, T.; Mindur, B.; Przybycień, M.; Rulikowska-Zarȩbska, E.; Suszycki, L.; Szuba, D.; Szuba, J.; Kotański, A.; Słomiński, W.; Bauerdick, L. A.; Behrens, U.; Borras, K.; Chiochia, V.; Dannheim, D.; Desler, K.; Drews, G.; Fourletova, J.; Fox-Murphy, A.; Fricke, U.; Geiser, A.; Goebel, F.; Göttlicher, P.; Graciani, R.; Haas, T.; Hain, W.; Hartner, G. F.; Hillert, S.; Kötz, U.; Kowalski, H.; Labes, H.; Lelas, D.; Löhr, B.; Mankel, R.; Martens, J.; Martínez, M.; Moritz, M.; Notz, D.; Petrucci, M. C.; Polini, A.; Schneekloth, U.; Selonke, F.; Stonjek, S.; Surrow, B.; Whitmore, J. J.; Wichmann, R.; Wolf, G.; Youngman, C.; Zeuner, W.; Coldewey, C.; Lopez-Duran Viani, A.; Meyer, A.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Genta, C.; Pelfer, P. G.; Bamberger, A.; Benen, A.; Coppola, N.; Markun, P.; Raach, H.; Wölfle, S.; Bell, M.; Bussey, P. J.; Doyle, A. T.; Glasman, C.; Hanlon, S.; Lee, S. W.; Lupi, A.; McCance, G. J.; Saxon, D. H.; Skillicorn, I. O.; Bodmann, B.; Holm, U.; Salehi, H.; Wick, K.; Ziegler, A.; Ziegler, Ar.; Carli, T.; Gialas, I.; Klimek, K.; Lohrmann, E.; Milite, M.; Collins-Tooth, C.; Foudas, C.; Gonçalo, R.; Long, K. R.; Metlica, F.; Miller, D. B.; Tapper, A. D.; Walker, R.; Cloth, P.; Filges, D.; Kuze, M.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Ahn, S. H.; Lee, S. B.; Park, S. K.; Lim, H.; Son, D.; Barreiro, F.; García, G.; González, O.; Labarga, L.; del Peso, J.; Redondo, I.; Terrón, J.; Vázquez, M.; Barbi, M.; Bertolin, A.; Corriveau, F.; Ochs, A.; Padhi, S.; Stairs, D. G.; St-Laurent, M.; Tsurugai, T.; Antonov, A.; Bashkirov, V.; Danilov, P.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Golubkov, Yu. A.; Katkov, I. I.; Khein, L. A.; Korotkova, N. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Solomin, A. N.; Vlasov, N. N.; Zotkin, S. A.; Bokel, C.; Engelen, J.; Grijpink, S.; Koffeman, E.; Kooijman, P.; Maddox, E.; Schagen, S.; Tassi, E.; Tiecke, H.; Tuning, N.; Velthuis, J. J.; Wiggers, L.; de Wolf, E.; Brümmer, N.; Bylsma, B.; Durkin, L. S.; Gilmore, J.; Ginsburg, C. M.; Kim, C. L.; Ling, T. Y.; Boogert, S.; Cooper-Sarkar, A. M.; Devenish, R. C.; Ferrando, J.; Matsushita, T.; Rigby, M.; Ruske, O.; Sutton, M. R.; Walczak, R.; Brugnera, R.; Carlin, R.; dal Corso, F.; Dusini, S.; Garfagnini, A.; Limentani, S.; Longhin, A.; Parenti, A.; Posocco, M.; Stanco, L.; Turcato, M.; Adamczyk, L.; Oh, B. Y.; Saull, P. R.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cormack, C.; Hart, J. C.; McCubbin, N. A.; Heusch, C.; Park, I. H.; Pavel, N.; Abramowicz, H.; Dagan, S.; Gabareen, A.; Kananov, S.; Kreisel, A.; Levy, A.; Abe, T.; Fusayasu, T.; Kohno, T.; Umemori, K.; Yamashita, T.; Hamatsu, R.; Hirose, T.; Inuzuka, M.; Kitamura, S.; Matsuzawa, K.; Nishimura, T.; Arneodo, M.; Cartiglia, N.; Cirio, R.; Costa, M.; Ferrero, M. I.; Maselli, S.; Monaco, V.; Peroni, C.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Galea, R.; Koop, T.; Levman, G. M.; Martin, J. F.; Mirea, A.; Sabetfakhri, A.; Butterworth, J. M.; Gwenlan, C.; Hall-Wilton, R.; Hayes, M. E.; Heaphy, E. A.; Jones, T. W.; Lane, J. B.; Lightwood, M. S.; West, B. J.; Ciborowski, J.; Ciesielski, R.; Grzelak, G.; Nowak, R. J.; Pawlak, J. M.; Smalska, B.; Sztuk, J.; Tymieniecka, T.; Ukleja, A.; Ukleja, J.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Plucinski, P.; Eisenberg, Y.; Gladilin, L. K.; Hochman, D.; Karshon, U.; Breitweg, J.; Chapin, D.; Cross, R.; Kçira, D.; Lammers, S.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Deshpande, A.; Dhawan, S.; Hughes, V. W.; Straub, P. B.; Bhadra, S.; Catterall, C. D.; Fourletov, S.; Menary, S.; Soares, M.; Standage, J.

    2002-05-01

    A search has been made for lepton-flavor-violating interactions of the type e+p-->lX, where l denotes a μ or τ with high transverse momentum, at a center-of-mass energy (s) of 300 GeV with an integrated luminosity of 47.7 pb-1 using the ZEUS detector at HERA. No evidence was found for lepton-flavor violation and constraints were derived on leptoquarks (LQs) that could mediate such interactions. For LQ masses below (s), limits are set on λeq1 (βlq), where λeq1 is the coupling of the LQ to an electron and a first-generation quark q1 and βlq is the branching ratio of the LQ to l and a quark. For LQ masses exceeding (s), limits are set on the four-fermion contact-interaction term λeqα λlqβ/M2LQ for leptoquarks that couple to an electron and a quark qα and also to l and a quark qβ. Some of the limits are also applicable to lepton-flavor-violating processes mediated by squarks in R-parity-violating supersymmetric models. In some cases involving heavy quarks and especially for l=τ, the ZEUS limits are the most stringent published to date.

  13. One drop chemical derivatization--DESI-MS analysis for metabolite structure identification.

    PubMed

    Lubin, Arnaud; Cabooter, Deirdre; Augustijns, Patrick; Cuyckens, Filip

    2015-07-01

    Structural elucidation of metabolites is an important part during the discovery and development process of new pharmaceutical drugs. Liquid Chromatography (LC) in combination with Mass Spectrometry (MS) is usually the technique of choice for structural identification but cannot always provide precise structural identification of the studied metabolite (e.g. site of hydroxylation and site of glucuronidation). In order to identify those metabolites, different approaches are used combined with MS data including nuclear magnetic resonance, hydrogen/deuterium exchange and chemical derivatization followed by LC-MS. Those techniques are often time-consuming and/or require extra sample pre-treatment. In this paper, a fast and easy to set up tool using desorption electrospray ionization-MS for metabolite identification is presented. In the developed method, analytes in solution are simply dried on a glass plate with printed Teflon spots and then a single drop of derivatization mixture is added. Once the spot is dried, the derivatized compound is analyzed. Six classic chemical derivatizations were adjusted to work as a one drop reaction and applied on a list of compounds with relevant functional groups. Subsequently, two successive reactions on a single spot of amoxicillin were tested and the methodology described was successfully applied on an in vitro incubated alprazolam metabolite. All reactions and analyses were performed within an hour and gave useful structural information by derivatizing functional groups, making the method a time-saving and efficient tool for metabolite identification if used in addition or in some cases as an alternative to common methods. PMID:26349641

  14. Deep exclusive electroproduction of {pi}{sup +} from data measured with the HERMES detector at DESY

    SciTech Connect

    Kaskulov, Murat M.; Mosel, Ulrich

    2009-08-15

    Deeply virtual electroproduction of pions in an exclusive reaction p(e,e{sup '}{pi}{sup +})n is studied using a two-component model that includes soft hadronic and hard partonic reaction mechanisms. The results are compared with the experimental data measured at HERMES in the deep inelastic region for values of Q{sup 2}>1 GeV{sup 2} and W{sup 2}>10 GeV{sup 2}. At forward angles the {pi}{sup +} cross section is longitudinal and is dominated by exchange of Regge poles, with {pi} being the dominant trajectory. The off-forward region with -t>1 GeV{sup 2} is transverse and shows the dominance of partonic subprocesses. An implication of the present results for the future JLab facilities is briefly discussed.

  15. Vibration measurements of high-heat-load monochromators for DESY PETRA III extension

    PubMed Central

    Kristiansen, Paw; Horbach, Jan; Döhrmann, Ralph; Heuer, Joachim

    2015-01-01

    The requirement for vibrational stability of beamline optics continues to evolve rapidly to comply with the demands created by the improved brilliance of the third-generation low-emittance storage rings around the world. The challenge is to quantify the performance of the instrument before it is installed at the beamline. In this article, measurement techniques are presented that directly and accurately measure (i) the relative vibration between the two crystals of a double-crystal monochromator (DCM) and (ii) the absolute vibration of the second-crystal cage of a DCM. Excluding a synchrotron beam, the measurements are conducted under in situ conditions, connected to a liquid-nitrogen cryocooler. The investigated DCM utilizes a direct-drive (no gearing) goniometer for the Bragg rotation. The main causes of the DCM vibration are found to be the servoing of the direct-drive goniometer and the flexibility in the crystal cage motion stages. It is found that the investigated DCM can offer relative pitch vibration down to 48 nrad RMS (capacitive sensors, 0–5 kHz bandwidth) and absolute pitch vibration down to 82 nrad RMS (laser interferometer, 0–50 kHz bandwidth), with the Bragg axis brake engaged. PMID:26134790

  16. Monitoring System for the GRID Monte Carlo Mass Production in the H1 Experiment at DESY

    NASA Astrophysics Data System (ADS)

    Bystritskaya, Elena; Fomenko, Alexander; Gogitidze, Nelly; Lobodzinski, Bogdan

    2014-06-01

    The H1 Virtual Organization (VO), as one of the small VOs, employs most components of the EMI or gLite Middleware. In this framework, a monitoring system is designed for the H1 Experiment to identify and recognize within the GRID the best suitable resources for execution of CPU-time consuming Monte Carlo (MC) simulation tasks (jobs). Monitored resources are Computer Elements (CEs), Storage Elements (SEs), WMS-servers (WMSs), CernVM File System (CVMFS) available to the VO HONE and local GRID User Interfaces (UIs). The general principle of monitoring GRID elements is based on the execution of short test jobs on different CE queues using submission through various WMSs and directly to the CREAM-CEs as well. Real H1 MC Production jobs with a small number of events are used to perform the tests. Test jobs are periodically submitted into GRID queues, the status of these jobs is checked, output files of completed jobs are retrieved, the result of each job is analyzed and the waiting time and run time are derived. Using this information, the status of the GRID elements is estimated and the most suitable ones are included in the automatically generated configuration files for use in the H1 MC production. The monitoring system allows for identification of problems in the GRID sites and promptly reacts on it (for example by sending GGUS (Global Grid User Support) trouble tickets). The system can easily be adapted to identify the optimal resources for tasks other than MC production, simply by changing to the relevant test jobs. The monitoring system is written mostly in Python and Perl with insertion of a few shell scripts. In addition to the test monitoring system we use information from real production jobs to monitor the availability and quality of the GRID resources. The monitoring tools register the number of job resubmissions, the percentage of failed and finished jobs relative to all jobs on the CEs and determine the average values of waiting and running time for the involved GRID queues. CEs which do not meet the set criteria can be removed from the production chain by including them in an exception table. All of these monitoring actions lead to a more reliable and faster execution of MC requests.

  17. Längengrad. Die wahre Geschichte eines einsamen Genies, welches das größte wissenschaftliche Problem seiner Zeit löste.

    NASA Astrophysics Data System (ADS)

    Sobel, D.

    This book is a German translation, by M. Fienbork, from the American original "Longitude", published in 1995. It tells the story of John Harrison (1693 - 1776), the inventor of a chronometer for precise time determination onboard of ships.

  18. Investigation of a direction sensitive sapphire detector stack at the 5 GeV electron beam at DESY-II

    NASA Astrophysics Data System (ADS)

    Karacheban, O.; Afanaciev, K.; Hempel, M.; Henschel, H.; Lange, W.; Leonard, J. L.; Levy, I.; Lohmann, W.; Schuwalow, S.

    2015-08-01

    Extremely radiation hard sensors are needed in particle physics experiments to instrument the region near the beam pipe. Examples are beam halo and beam loss monitors at the Large Hadron Collider, FLASH or XFEL. Currently artificial diamond sensors are widely used. In this paper single crystal sapphire sensors are considered as a promising alternative. Industrially grown sapphire wafers are available in large sizes, are of low cost and, like diamond sensors, can be operated without cooling. Here we present results of an irradiation study done with sapphire sensors in a high intensity low energy electron beam. Then, a multichannel direction-sensitive sapphire detector stack is described. It comprises 8 sapphire plates of 1 cm2 size and 525 μ m thickness, metallized on both sides, and apposed to form a stack. Each second metal layer is supplied with a bias voltage, and the layers in between are connected to charge-sensitive preamplifiers. The performance of the detector was studied in a 5 GeV electron beam. The charge collection efficiency measured as a function of the bias voltage rises with the voltage, reaching about 10% at 095 V. The signal size obtained from electrons crossing the stack at this voltage is about 02200 e, where e is the unit charge. The signal size is measured as a function of the hit position, showing variations of up to 20% in the direction perpendicular to the beam and to the electric field. The measurement of the signal size as a function of the coordinate parallel to the electric field confirms the prediction that mainly electrons contribute to the signal. Also evidence for the presence of a polarisation field was observed.

  19. Development of a scanning transmission x-ray microscope for the beamline P04 at PETRA III DESY

    NASA Astrophysics Data System (ADS)

    Andrianov, Konstantin; Ewald, Johannes; Nisius, Thomas; Lühl, Lars; Malzer, Wolfgang; Kanngießer, Birgit; Wilhein, Thomas

    2016-01-01

    We present a scanning transmission x-ray microscope (STXM) built on top of our existing modular platform for high resolution imaging experiments. This platform consists of up to three separate vacuum chambers and custom designed piezo stages. These piezo stages are able to move precisely in x-, y- and z-direction, this makes it possible to adjust the components for different imaging modes. During recent experiments the endstation was operated mainly as a transmission x-ray microscope (TXM) [1, 2].

  20. Desi Women on the Forty Acres: Exploring Intergenerational Issues and Identity Development of South Asian American College Students

    ERIC Educational Resources Information Center

    Ruzicka, Smita Sundaresan

    2011-01-01

    South Asian Americans are one of the fastest growing sub-groups within the Asian American population in the United States today. Between 1960 and 1990, the South Asian American population witnessed an increase of approximately 900% (Leonard, 1997). This increase in population also corresponds with the increase in South Asian American students…

  1. DESI-Detection of early-season invasives (software-installation manual and user's guide version 1.0)

    USGS Publications Warehouse

    Kokaly, Raymond F.

    2011-01-01

    This report describes a software system for detecting early-season invasive plant species, such as cheatgrass. The report includes instructions for installing the software and serves as a user's guide in processing Landsat satellite remote sensing data to map the distributions of cheatgrass and other early-season invasive plants. The software was developed for application to the semi-arid regions of southern Utah; however, the detection parameters can be altered by the user for application to other areas.

  2. The soft x-ray free-electron laser FLASH at DESY: beamlines, diagnostics and end-stations

    NASA Astrophysics Data System (ADS)

    Tiedtke, K.; Azima, A.; von Bargen, N.; Bittner, L.; Bonfigt, S.; Düsterer, S.; Faatz, B.; Frühling, U.; Gensch, M.; Gerth, Ch; Guerassimova, N.; Hahn, U.; Hans, T.; Hesse, M.; Honkavaar, K.; Jastrow, U.; Juranic, P.; Kapitzki, S.; Keitel, B.; Kracht, T.; Kuhlmann, M.; Li, W. B.; Martins, M.; Núñez, T.; Plönjes, E.; Redlin, H.; Saldin, E. L.; Schneidmiller, E. A.; Schneider, J. R.; Schreiber, S.; Stojanovic, N.; Tavella, F.; Toleikis, S.; Treusch, R.; Weigelt, H.; Wellhöfer, M.; Wabnitz, H.; Yurkov, M. V.; Feldhaus, J.

    2009-02-01

    FLASH, the Free-electron LASer in Hamburg, is a worldwide unique source for extremely bright ultra-short laser-like pulses tunable in a wide spectral range in the extreme ultraviolet and soft x-ray region (Ackermann et al 2007 Nat. Photonics 1 336-42). To fully exploit the features of this new generation of light sources, a user facility with efficient radiation transport to the experimental area and novel online photon diagnostics capable of characterizing the unique parameters of the FLASH radiation has been built. It serves a broad user community active in many scientific fields ranging from atomic and molecular physics to plasma and solid state physics as well as chemistry and biology. A special focus is placed on the exploitation of the ultra-short FLASH pulses using pump-probe techniques. Thus, the facility is equipped with optical and THz sources synchronized to FLASH. This paper gives a detailed overview of the FLASH user facility.

  3. Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Zheng, Qiuling; Chen, Hao

    2016-06-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical applications in bioanalysis, proteomics, and reaction kinetics. Due to the capability of directly ionizing liquid samples, liquid sample DESI (LS-DESI) has been successfully used to couple MS with various analytical techniques, such as microfluidics, microextraction, electrochemistry, and chromatography. This review also covers these hyphenated techniques. In addition, several closely related ionization methods, including transmission mode DESI, thermally assisted DESI, and continuous flow–extractive DESI, are briefly discussed. The capabilities of LS-DESI extend and/or complement the utilities of traditional DESI and electrospray ionization and will find extensive and valuable analytical application in the future.

  4. Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry.

    PubMed

    Zheng, Qiuling; Chen, Hao

    2016-06-12

    Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical applications in bioanalysis, proteomics, and reaction kinetics. Due to the capability of directly ionizing liquid samples, liquid sample DESI (LS-DESI) has been successfully used to couple MS with various analytical techniques, such as microfluidics, microextraction, electrochemistry, and chromatography. This review also covers these hyphenated techniques. In addition, several closely related ionization methods, including transmission mode DESI, thermally assisted DESI, and continuous flow-extractive DESI, are briefly discussed. The capabilities of LS-DESI extend and/or complement the utilities of traditional DESI and electrospray ionization and will find extensive and valuable analytical application in the future. PMID:27145689

  5. Function of desiccate in gustatory sensilla of drosophila melanogaster

    PubMed Central

    Kawano, Takeshi; Ryuda, Masasuke; Matsumoto, Hitoshi; Ochiai, Masanori; Oda, Yasunori; Tanimura, Teiichi; Csikos, Gyorge; Moriya, Megumi; Hayakawa, Yoichi

    2015-01-01

    Desiccate (Desi), initially discovered as a gene expressing in the epidermis of Drosophila larvae for protection from desiccation stress, was recently found to be robustly expressed in the adult labellum; however, the function, as well as precise expression sites, was unknown. Here, we found that Desi is expressed in two different types of non-neuronal cells of the labellum, the epidermis and thecogen accessory cells. Labellar Desi expression was significantly elevated under arid conditions, accompanied by an increase in water ingestion by adults. Desi overexpression also promoted water ingestion. In contrast, a knockdown of Desi expression reduced feeding as well as water ingestion due to a drastic decrease in the gustatory sensillar sensitivity for all tested tastants. These results indicate that Desi helps protect insects from desiccation damage by not only preventing dehydration through the integument but also accelerating water ingestion via elevated taste sensitivities of the sensilla. PMID:26610608

  6. Desorption Electrospray Ionization Mass Spectrometry for Lipid Characterization and Biological Tissue Imaging

    PubMed Central

    Eberlin, Livia S.; Ferreira, Christina R.; Dill, Allison L.; Ifa, Demian R.; Cooks, R. Graham

    2011-01-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. PMID:21645635

  7. Menschliches Erkennen in evolutionärer Sicht

    NASA Astrophysics Data System (ADS)

    Vollmer, Gerhard

    Es war einige Zeit Mode - etwa bei der Frankfurter Allgemeinen Zeitung -, prominenten Zeitgenossen einen Fragebogen vorzulegen. Da stand dann: Wer ist Ihr Lieblingsautor? Welche Person bewundern Sie am meisten? Eine dieser Fragen hieß: Was halten Sie für die wichtigste wissenschaftliche Erkenntnis überhaupt? Als Philosoph hätte ich Skrupel, eine solche Bewertung vorzunehmen. Der Physiker Gerd Binnig, 1986 Nobelpreisträger für das Rastertunnelmikroskop, hat die Frage kurzerhand beantwortet: Für ihn ist die wichtigste wissenschaftliche Entdeckung die Darwin'sche Theorie.

  8. Supraleitung und Interkontinentalraketen „On-line computing“ zwischen Militär, Industrie und Wissenschaft

    NASA Astrophysics Data System (ADS)

    Knolle, Johannes; Joas, Christian

    Der zweite Weltkrieg und der Kalte Krieg veränderten nicht nur das Verhältnis zwischen Militär, Industrie und Wissenschaft, sondern auch die wissenschaftliche Praxis von Physikern und anderen Wissenschaftlern. In den 1950er Jahren stellte die Entwicklung von Interkontinentalraketen die Auftragnehmer des Militärs in der Industrie vor komplexe Fragestellungen, zu deren Lösung sie auf die Expertise von Wissenschaftlern angewiesen waren. Industrieunternehmen gründeten eigene Forschungseinheiten zur Lösung technischer und wissenschaftlicher Probleme.

  9. Desorption electrospray ionization-mass spectrometry of proteins

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Desorption electrospray ionization-mass spectrometry (DESI-MS) was evaluated for the detection of proteins ranging in molecular mass from 12 to 66 kDa. Proteins were uniformly deposited on a solid surface without pretreatment and analyzed with a DESI source coupled to a quadrupole ion trap mass spec...

  10. Desorption electrospray ionization mass spectrometry of intact bacteria

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Desorption electrospray ionization (DESI) mass spectrometry (MS) was used to differentiate 7 bacterial species based on their measured DESI-mass spectral profile. Both Gram positive and Gram negative bacteria were tested and included Escherichia coli, Staphyloccocus aureus, Enterococcus sp., Bordete...

  11. Europäisches Organ der Festkörperforschung und DDR-Devisenbringer Die Zeitschrift Physica Status Solidi im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Mit dem Ziele, ein einheitliches internationales Organ der Festkörperphysik für den europäischen Raum zu schaffen, das eine rasche Publikation der für das Festkörpergebiet repräsentative Arbeiten ermöglicht, wird durch ein internationales Herausgebergremium eine neue wissenschaftliche Zeitschrift gegründet.

  12. TÜV - Zertifizierungen in der Life Science Branche

    NASA Astrophysics Data System (ADS)

    Schaff, Peter; Gerbl-Rieger, Susanne; Kloth, Sabine; Schübel, Christian; Daxenberger, Andreas; Engler, Claus

    Life Sciences [1] (Lebenswissenschaften) sind ein globales Innovationsfeld mit Anwendungen der Bio- und Medizinwissenschaften, der Pharma-, Chemie-, Kosmetik- und Lebensmittelindustrie. Diese Branche zeichnet sich durch eine stark interdisziplinäre Ausrichtung aus, mit Anwendung wissenschaftlicher Erkenntnisse und Einsatz von Ausgangsstoffen aus der modernen Biologie, Chemie und Humanmedizin sowie gezielter marktwirtschaftlich orientierter Arbeit.

  13. Von Tondern nach Gotha. Der Astronom Peter Andreas Hansen, 1795 - 1874.

    NASA Astrophysics Data System (ADS)

    Strumpf, M.; Pehlemann, E.; Wolfschmidt, G.

    This companion booklet to an exposition in honor of Peter Andreas Hansen's 200th birthday contains three papers. Contents: 1. Peter Andreas Hansen - Leben und Wirken in Gotha (M. Strumpf). 2. Peter Andreas Hansens wissenschaftliches Werk (E. Pehlemann). 3. Beobachtungsinstrumente der Sternwarte Gotha zur Zeit Hansens (G. Wolfschmidt).

  14. Lateral resolution of desorption nanoelectrospray: a nanospray tip without nebulizing gas as a source of primary charged droplets.

    PubMed

    Hartmanová, L; Lorencová, I; Volný, M; Fryčák, P; Havlíček, V; Chmelíčková, H; Ingr, T; Lemr, K

    2016-04-01

    Desorption nanoelectrospray (nanoDESI) was described in 2007 and it represents a miniaturized version of desorption electrospray without the assistance of the nebulizing gas. Compared to DESI, a nanoelectrospray tip (2 ± 1 μm I.D.) generates primary charged droplets of smaller sizes and lower spray liquid flow rates. This is the first report on utilization of nanoDESI for mass spectrometry imaging (MSI). Its new coupling with a Q-TOF instrument allowed faster mass spectra acquisition (4 Hz) essential for MSI of fine surface details. To evaluate nanoDESI potential for mass spectrometry imaging, etched glass substrates with Rhodamine B patterns of different dimensions were prepared. The Rhodamine B lines were analysed in 1D scanning mode and their width was determined experimentally by nanoDESI measurement. The experimental data revealed that the lateral resolution of nanoDESI is close to 30 μm along the x-axis (orthogonal to the inlet). 2D scanning mode confirmed good resolution along both axes as dye squares with dimensions about 60 μm × 60 μm were easily distinguished. The low flow rate of the spray liquid reduced undesirable analyte washing effects, which allowed repeated scanning analysis of the surface. The presented results demonstrate the applicability of nanoDESI for high surface resolution mass spectrometry imaging. PMID:26958660

  15. Evaluation of volatile compounds in different types of ghee using direct injection with gas chromatography-mass spectrometry.

    PubMed

    Wadodkar, Uday R; Punjrath, Jagjit S; Shah, Amrish C

    2002-02-01

    Desi ghee (DG) was prepared from fermented cream followed by heat clarification (desi method) in the laboratory and butter oil (BO) was prepared from fresh butter by melting and centrifugation. Fresh samples of three brands of industrial ghee (IG-1, IG-2, IG-3) were collected from the local market. Volatile compounds of desi and industrial ghee and butter oil were isolated and concentrated using direct injection and cryofocussing techniques; separation and identification was by Gas Chromatography Mass Spectrometry (GCMS). A maximum of 36 compounds were detected in desi ghee whereas compounds detected in three industrial ghee samples varied from 22-29. The lowest number of compounds (16) was detected in butter oil. Of the identified compounds, maltol, 5-hydroxymethyl furfuraldehyde, dihydrodihydroxypyranone, 1,3-butanediol and 1-octanol were identified only in desi ghee volatiles. The concentration of acetic acid was found to be remarkably higher in desi ghee volatiles than in industrial ghee. Also the levels of identified fatty acids, methyl ketones, aldehydes, lactones and alcohols were high in desi ghee volatiles compared with industrial ghee and butter oil. In total, 62 compounds were detected, which included 6 aldehydes, 12 ketones, 8 each of fatty acids, alcohols and lactones, 4 each of esters and hydrocarbons or other compounds, and 12 compounds remained unidentified. PMID:12047107

  16. Surface effects and electrochemical cell capacitance in desorption electrospray ionization.

    PubMed

    Volný, Michael; Venter, Andre; Smith, Scott A; Pazzi, Marco; Cooks, R Graham

    2008-04-01

    Time resolved measurements show that during a desorption electrospray ionization (DESI) experiment, the current initially rises sharply, followed by an exponential decrease to a relatively steady current. When the high voltage on the spray emitter is switched off, the current drops to negative values, suggesting that the direction of current flow in the equivalent DESI circuit is reversed. These data demonstrate that the DESI source behaves as a dc capacitor and that the addition of a surface between the sprayer and the counter electrode in DESI introduces a new electrically active element into the system. The charging and discharging behavior was observed using different surfaces and it could be seen both by making current measurements on a plate at the entrance to the mass spectrometer as well as by measuring ion current in the linear ion trap within the vacuum system of the mass spectrometer. The magnitude of the steady state current obtained without analyte present on the surface is different for different surface materials, and different capacitor time constants of the equivalent RC circuits were calculated for different DESI surfaces. The PTFE surface has by far the greatest time constant and is also able to produce the highest DESI currents. Surface properties play a crucial role in charge transfer during DESI in addition to the effects of the chemical properties of the analyte. It is suggested that surface energy (wettability) is an important factor controlling droplet behavior on the surface. The experimental data are correlated with critical surface tension values of different materials. It is proposed, based on the results presented, that super-hydrophobic materials with extremely high contact angles have the potential to be excellent DESI substrates. It is also demonstrated, using the example of the neurotransmitter dopamine, that the surface charge that develops during a DESI-MS experiment can cause electrochemical oxidation of the analyte. PMID

  17. Analysis of sexual assault evidence by desorption electrospray ionization mass spectrometry.

    PubMed

    Mirabelli, Mario F; Chramow, Alexander; Cabral, Elaine C; Ifa, Demian R

    2013-07-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) is employed in the forensic analysis of chemical components present in condoms and imaging of latent fingerprints as circumstantial evidence of sexual assault. Polymers such as nonoxynol-9, polyethylene glycol, and polydimethylsiloxane, as well as small molecules additives such as N-methylmorpholine, N-octylamine, N,N-dibutyl formamide, and isonox 132, commonly used in lubricated condom formulations, were successfully characterized by DESI. The results suggest that DESI-MS is useful for identification of this type of evidence, and it has advantages over conventional extractive techniques, in terms of speed of analysis and ease of use. PMID:23832933

  18. STATISTICAL PROPERTIES OF DESIGNS FOR SAMPLING CONTINUOUS FUNCTIONS IN TWO DIMENSIONS USING A TRIANGULAR GRID

    EPA Science Inventory

    The U.S. Environmental Protection Agency's (EPA) Environmental Monitoring and Assessment Program (EMAP) is a current initiative designed to identify and bound the extent, magnitude, and location of degradation or improvement in environmental condition. he proposed monitoring desi...

  19. Determination of T-2 and HT-2 toxins from maize by direct analysis in real time - mass spectrometry (DART-MS)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ambient desorption ionization techniques, such as laser desorption with electrospray ionization assistance (ELDI), direct analysis in real time (DART) and desorption electrospray ionization (DESI) have been developed as alternatives to traditional mass spectrometric-based methods. Such techniques al...

  20. Shotgun Approach for Quantitative Imaging of Phospholipids Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect

    Lanekoff, Ingela T.; Thomas, Mathew; Laskin, Julia

    2014-02-04

    Mass spectrometry imaging (MSI) has been extensively used for determining spatial distributions of molecules in biological samples, and there is increasing interest in using MSI for quantification. Nanospray desorption electrospray ionization, or nano-DESI, is an ambient MSI technique where a solvent is used for localized extraction of molecules followed by nanoelectrospray ionization. Doping the nano-DESI solvent with carefully selected standards enables online quantification during MSI experiments. In this proof-of-principle study, we demonstrate this quantification approach can be extended to provide shotgun-like quantification of phospholipids in thin brain tissue sections. Specifically, two phosphatidylcholine (PC) standards were added to the nano-DESI solvent for simultaneous imaging and quantification of 22 PC species observed in nano-DESI MSI. Furthermore, by combining the quantitative data obtained in the individual pixels, we demonstrate quantification of these PC species in seven different regions of a rat brain tissue section.

  1. High Energy Physics: Report of research accomplishments and future goals, FY 1983

    SciTech Connect

    Barish, B C

    1983-12-31

    Continuing research in high energy physics carried out by the group from the California Institute of Technology. The program includes research in theory, phenomenology, and experimental high energy physics. The experimental program includes experiments at SLAC, FERMILAB, and DESY.

  2. JWST Primary Mirror Installation Complete

    NASA Video Gallery

    Completing the assembly of the primary mirror, which took place at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, is a significant milestone and the culmination of over a decade of desi...

  3. FIELD APPLICATIONS OF CHEMICAL TIME-SERIES SAMPLING

    EPA Science Inventory

    Two municipal supply wells in Lakewood, Washington, were found to be contaminated with trichloroethylene, transdichloroethylene, and tetrachloroethylene. Sequential samples were taken for chemical analyses, in conjunction with drawdown measurement during aquifer (pump) tests desi...

  4. Molecular Characterization of Organic Aerosols Using Nanospray Desorption/Electrospray Ionization-Mass Spectrometry

    SciTech Connect

    Roach, Patrick J.; Laskin, Julia; Laskin, Alexander

    2010-10-01

    Nanospray desorption electrospray ionization (Nano-DESI) combined with high-resolution mass spectrometry (HR/MS) is a promising approach for detailed chemical characterization of atmospheric organic aerosol (OA) collected in laboratory and field experiments. In Nano-DESI analyte is desorbed into a solvent bridge formed between two capillaries and the analysis surface, which enables fast and efficient characterization of OA collected on substrates without special sample preparation. Stable signals achieved using Nano-DESI make it possible to obtain high-quality HR/MS data using only a small amount of material (<10 ng). Furthermore, Nano-DESI enables efficient detection of chemically labile compounds in OA, which is important for understanding chemical aging phenomena.

  5. Improved Imaging Resolution in Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect

    Kertesz, Vilmos; Van Berkel, Gary J

    2008-01-01

    Imaging resolution of desorption electrospray ionization mass spectrometry (DESI-MS) was investigated using printed patterns on paper and thin-layer chromatography (TLC) plate surfaces. Resolution approaching 40 m was achieved with a typical DESI-MS setup, which is approximately 5 times better than the best resolution reported previously. This improvement was accomplished with careful control of operational parameters (particularly spray tip-to-surface distance, solvent flow rate, and spacing of lane scans). Also, an appropriately strong analyte/surface interaction and uniform surface texture on the size scale no larger that the desired imaging resolution were required to achieve this resolution. Overall, conditions providing the smallest possible effective desorption/ionization area in the DESI impact plume region and minimizing the analyte redistribution on the surface during analysis led to the improved DESI-MS imaging resolution.

  6. Recent Tests for the Statistical Parton Distributions

    NASA Astrophysics Data System (ADS)

    Bourrely, Claude; Soffer, Jacques; Buccella, Franco

    We compare some recent experimental results obtained at DESY, SLAC and Jefferson Lab., with the predictions of the statistical model, we have previously proposed. The result of this comparison is very satisfactory.

  7. Signal and Charge Enhancement for Protein Analysis by Liquid Chromatography-Mass Spectrometry with Desorption Electrospray Ionization

    PubMed Central

    Liu, Yan; Miao, Zhixin; Lakshmanan, Rajeswari; Ogorzalek Loo, Rachel R.; Loo, Joseph A.; Chen, Hao

    2015-01-01

    We recently reported the use of desorption electrospray ionization (DESI) as a novel interface to couple high-performance liquid chromatography (HPLC) with mass spectrometry (MS) (Chem. Commun. 2011, 47, 4171). One of the benefits of such an interface is that post-column derivatization of separated analytes can be integrated with ionization via a “reactive” DESI approach in which a derivatizing reagent is doped into the spray solvent. The reactive DESI interface allows analyte desorption/ionization from the end of the chromatographic column with prompt MS detection; a short time delay of ~20 ms was demonstrated. In this study, we extended this application by “supercharging” proteins following HPLC separation using a DESI spray solvent containing supercharging reagents, m-nitrobenzyl alcohol (m-NBA) or sulfolane. Proteins (insulin, ubiquitin, lysozyme and α-lactalbumin) eluted out of the LC column can be supercharged with the protein charge state distributions (CSDs) significantly increased (to higher charge), which would be advantageous for subsequent top-down MS analysis of proteins. Interestingly, supercharging combined with reactive DESI enhances tolerance towards trifluoroacetic acid (TFA), which is known to be a superior additive in the mobile phase for premium peptide/protein chromatographic separation but has severe signal suppression effects for conventional electrospray ionization (ESI). In comparison to electrosonic spray ionization (ESSI), a variant form of ESI, the sensitivity of protein analysis using LC/DESI-MS with the mobile phase containing TFA can be improved by up to 70-fold for lysozyme and α-lactalbumin by including m-NBA in the DESI spray solvent. Presumably, by reducing TFA dissociation in the droplet, supercharging agents lower trifluoroacetate anion concentrations and concomitantly reduce ion pairing to analyte cationic sites. The reduced ion pairing therefore decreases the TFA signal suppression effect. The supercharging

  8. Remote mass spectrometric sampling of electrospray- and desorption electrospray-generated ions using an air ejector.

    PubMed

    Dixon, R Brent; Bereman, Michael S; Muddiman, David C; Hawkridge, Adam M

    2007-10-01

    A commercial air ejector was coupled to an electrospray ionization linear ion trap mass spectrometer (LTQ) to transport remotely generated ions from both electrospray (ESI) and desorption electrospray ionization (DESI) sources. We demonstrate the remote analysis of a series of analyte ions that range from small molecules and polymers to polypeptides using the AE-LTQ interface. The details of the ESI-AE-LTQ and DESI-AE-LTQ experimental configurations are described and preliminary mass spectrometric data are presented. PMID:17716909

  9. Remote Mass Spectrometric Sampling of Electrospray- and Desorption Electrospray-Generated Ions Using an Air Ejector

    PubMed Central

    Dixon, R. Brent; Bereman, Michael S.; Muddiman, David C.; Hawkridge, Adam M.

    2007-01-01

    A commercial air ejector was coupled to an electrospray ionization linear ion trap mass spectrometer (LTQ) to transport remotely generated ions from both electrospray (ESI) and desorption electrospray ionization (DESI) sources. We demonstrate the remote analysis of a series of analyte ions that range from small molecules and polymers to polypeptides using the AE-LTQ interface. The details of the ESI-AE-LTQ and DESI-AE-LTQ experimental configurations are described and preliminary mass spectrometric data is presented. PMID:17716909

  10. Study of Electrochemical Reactions Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect

    Liu, Pengyuan; Lanekoff, Ingela T.; Laskin, Julia; Dewald, Howard D.; Chen, Hao

    2012-07-03

    The combination of electrochemistry (EC) and mass spectrometry (MS) is a powerful analytical tool for studying mechanisms of redox reactions, identification of products and intermediates, and online derivatization/recognition of analytes. This work reports a new coupling interface for EC/MS by employing nanospray desorption electrospray ionization (nano-DESI), a recently developed ambient ionization method. We demonstrate online coupling of nano-DESI-MS with a traditional electrochemical flow cell, in which the electrolyzed solution emanating from the cell is ionized by nano-DESI for MS analysis. Furthermore, we show first coupling of nano-DESI-MS with an interdigitated array (IDA) electrode enabling chemical analysis of electrolyzed samples directly from electrode surfaces. Because of its inherent sensitivity, nano-DESI enables chemical analysis of small volumes and concentrations of sample solution. Specifically, good-quality signal of dopamine and its oxidized form, dopamine ortho-quinone, was obtained using 10 μL of 1 μM solution of dopamine on the IDA. Oxidation of dopamine, reduction of benzodiazepines, and electrochemical derivatization of thiol groups were used to demonstrate the performance of the technique. Our results show the potential of nano-DESI as a novel interface for electrochemical mass spectrometry research.

  11. Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation.

    PubMed

    Škrášková, Karolina; Claude, Emmanuelle; Jones, Emrys A; Towers, Mark; Ellis, Shane R; Heeren, Ron M A

    2016-07-15

    The increased interest in lipidomics calls for improved yet simplified methods of lipid analysis. Over the past two decades, mass spectrometry imaging (MSI) has been established as a powerful technique for the analysis of molecular distribution of a variety of compounds across tissue surfaces. Matrix-assisted laser desorption/ionization (MALDI) MSI is widely used to study the spatial distribution of common lipids. However, a thorough sample preparation and necessity of vacuum for efficient ionization might hamper its use for high-throughput lipid analysis. Desorption electrospray ionization (DESI) is a relatively young MS technique. In DESI, ionization of molecules occurs under ambient conditions, which alleviates sample preparation. Moreover, DESI does not require the application of an external matrix, making the detection of low mass species more feasible due to the lack of chemical matrix background. However, irrespective of the ionization method, the final information obtained during an MSI experiment is very complex and its analysis becomes challenging. It was shown that coupling MSI to ion mobility separation (IMS) simplifies imaging data interpretation. Here we employed DESI and MALDI MSI for a lipidomic analysis of the murine brain using the same IMS-enabled instrument. We report for the first time on the DESI IMS-MSI of multiply sialylated ganglioside species, as well as their acetylated versions, which we detected directly from the murine brain tissue. We show that poly-sialylated gangliosides can be imaged as multiply charged ions using DESI, while they are clearly separated from the rest of the lipid classes based on their charge state using ion mobility. This represents a major improvement in MSI of intact fragile lipid species. We additionally show that complementary lipid information is reached under particular conditions when DESI is compared to MALDI MSI. PMID:26922843

  12. Chemical Characterization of Crude Petroleum Using Nanospray Desorption Electrospray Ionization Coupled with High-Resolution Mass Spectrometry

    SciTech Connect

    Eckert, Peter A.; Roach, Patrick J.; Laskin, Alexander; Laskin, Julia

    2012-02-07

    Nanospray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry was used for the first time for the analysis of liquid petroleum crude oil samples. The analysis was performed in both positive and negative ionization modes using three solvents one of which (acetonitrile/toluene mixture) is commonly used in petroleomics studies while two other polar solvents (acetonitrile/water and methanol/water mixtures) are generally not compatible with petroleum characterization using mass spectrometry. The results demonstrate that nano-DESI analysis efficiently ionizes petroleum constituents soluble in a particular solvent. When acetonitrile/toluene is used as a solvent, nano-DESI generates electrospray-like spectra. In contrast, strikingly different spectra were obtained using acetonitrile/water and methanol/water. Comparison with the literature data indicates that these solvents selectively extract water-soluble constituents of the crude oil. Water-soluble compounds are predominantly observed as sodium adducts in nano-DESI spectra indicating that addition of sodium to the solvent may be a viable approach for efficient ionization of water-soluble crude oil constituents. Nano-DESI enables rapid screening of different classes of compounds in crude oil samples using solvents that are rarely used for petroleum characterization.

  13. Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry

    PubMed Central

    Fernández, Facundo M.

    2013-01-01

    Mass spectrometry imaging (MSI) provides untargeted molecular information with the highest specificity and spatial resolution for investigating biological tissues at the hundreds to tens of microns scale. When performed under ambient conditions, sample pre-treatment becomes unnecessary, thus simplifying the protocol while maintaining the high quality of information obtained. Desorption electrospray ionization (DESI) is a spray-based ambient MSI technique that allows for the direct sampling of surfaces in the open air, even in vivo. When used with a software-controlled sample stage, the sample is rastered underneath the DESI ionization probe, and through the time domain, m/z information is correlated with the chemical species' spatial distribution. The fidelity of the DESI-MSI output depends on the source orientation and positioning with respect to the sample surface and mass spectrometer inlet. Herein, we review how to prepare tissue sections for DESI imaging and additional experimental conditions that directly affect image quality. Specifically, we describe the protocol for the imaging of rat brain tissue sections by DESI-MSI. PMID:23892773

  14. Computing at h1 - Experience and Future

    NASA Astrophysics Data System (ADS)

    Eckerlin, G.; Gerhards, R.; Kleinwort, C.; KrÜNer-Marquis, U.; Egli, S.; Niebergall, F.

    The H1 experiment has now been successfully operating at the electron proton collider HERA at DESY for three years. During this time the computing environment has gradually shifted from a mainframe oriented environment to the distributed server/client Unix world. This transition is now almost complete. Computing needs are largely determined by the present amount of 1.5 TB of reconstructed data per year (1994), corresponding to 1.2 × 107 accepted events. All data are centrally available at DESY. In addition to data analysis, which is done in all collaborating institutes, most of the centrally organized Monte Carlo production is performed outside of DESY. New software tools to cope with offline computing needs include CENTIPEDE, a tool for the use of distributed batch and interactive resources for Monte Carlo production, and H1 UNIX, a software package for automatic updates of H1 software on all UNIX platforms.

  15. Handsfree Surface Analysis

    SciTech Connect

    2006-11-01

    The HANDSFREE SURFACE ANALYSIS software code enables unattended analysis of surfaces by desorption electrospray (DESI) and liquid-junction surface sampling probe (SSP) mass spectrometry. The software allows automated lane scanning, imaging (e.g. lane rastering), spot and array sampling, and array scanning methods by controlling the movement of the sample attached to a computer-controlled stage. The software is able to collect, visualize and analyze mass spectrometry data real-time for surface analysis purposes by interacting with mass spectrometry instrumentation software. The software also enables data post processing for imaging and other analytical purposes. The software also contains image analysis approaches to control the sampling capillary-to-surface distance when used with DESI, and for automated formation and real-time reoptimization of the sampling probe-to-surface liquid microjunction when used with SSP. Control of these distances is essential to automated, hands-free operation of a DESI or SSP mass spectrometry system.

  16. Studies on gastrointestinal parasites of pigs in Shimoga region of Karnataka.

    PubMed

    Krishna Murthy, C M; Ananda, K J; Adeppa, J; Satheesha, M G

    2016-09-01

    The study was conducted to ascertain the actual status of gastro-intestinal parasites in pigs maintained under different rearing systems in Shimoga region, Karnataka state. A total of 150 Pigs fecal samples were examined, which includes 50 from organized piggery farm, Veterinary College Shimoga, 50 from private piggery farm of Shimoga and 50 from free range desi pigs of Shimoga city. The fecal samples were processed and examined by direct and sedimentation method. Out of 50 fecal samples examined from organized piggery farm, 19 were found positive for different parasitic eggs, Out of 50 fecal samples screened form private farm, 28 harbored different parasites, whereas from 50 free range desi pigs fecal samples examined, all showed one and other parasitic eggs/ova. The percent prevalence of parasitic infection is more in free range desi pigs compared to Yorkshire breeds maintained under stall fed condition. PMID:27605803

  17. Nanospray Desorption Electrospray Ionization: an Ambient Method for Liquid-Extraction Surface Sampling in Mass Spectrometry

    SciTech Connect

    Roach, Patrick J.; Laskin, Julia; Laskin, Alexander

    2010-08-17

    A novel nanospray desorption electrospray ionization (nano-DESI) approach is presented and its analytical applications are demonstrated for trace analysis of complex organic analytes deposited on substrates. In this approach the analyte is probed by a micro-droplet of charged solvent formed at the junction between two capillaries. One primary capillary is used to create and maintain a charged micro-droplet of solvent on the substrate while a second capillary is used to create a self-aspirating nanospray that delivers solvent dissolved analyte to the inlet of a mass spectrometer. This approach enables efficient separation of desorption and ionization events, thus providing better control over transport and ionization of the analyte. In this letter we present the basics of the nano-DESI approach and demonstrate its analytical capabilities. Specifically, we demonstrate significant improvement of the limits of detection and the stability of the signal as compared to the traditional DESI and discuss imaging applications.

  18. Chemical Aspects of the Extractive Methods of Ambient Ionization Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Badu-Tawiah, Abraham K.; Eberlin, Livia S.; Ouyang, Zheng; Cooks, R. Graham

    2013-04-01

    Ambient ionization techniques allow complex chemical samples to be analyzed in their native state with minimal sample preparation. This brings the obvious advantages of simplicity, speed, and versatility to mass spectrometry: Desorption electrospray ionization (DESI), for example, is used in chemical imaging for tumor margin diagnosis. This review on the extractive methods of ambient ionization focuses on chemical aspects, mechanistic considerations, and the accelerated chemical reactions occurring in charged liquid droplets generated in the spray process. DESI uses high-velocity solvent droplets to extract analytes from surfaces. Nano-DESI employs liquid microjunctions for analyte dissolution, whereas paper-spray ionization uses DC potentials applied to wet porous material such as paper or biological tissue to field emit charged analyte-containing solvent droplets. These methods also operate in a reactive mode in which added reagents allow derivatization during ionization. The accelerated reaction rates seen in charged microdroplets are useful in small-scale rapid chemical synthesis.

  19. Fifty not out

    NASA Astrophysics Data System (ADS)

    2009-12-01

    What have the DESY laboratory in Germany, Richard Feynman's visionary lecture on nanotechnology, the discovery of the Aharonov-Bohm effect and the "two cultures" debate got in common? The answer is that they are all half a century old this year. The DESY lab was officially launched on 18 December 1959 and is marking its 50th anniversary with a series of events that included the official opening of the PETRA III synchrotron last month. Initially a particle-physics lab pure and simple, DESY is now changing its focus to accelerator science and is set to open its massive new 1bn European X-ray Free Electron Laser in 2014 (p12).

  20. Coupling desorption electrospray ionization with solid-phase microextraction for screening and quantitative analysis of drugs in urine.

    PubMed

    Kennedy, Joseph H; Aurand, Craig; Shirey, Robert; Laughlin, Brian C; Wiseman, Justin M

    2010-09-01

    Direct analysis of silica C(18)-coated solid-phase microextraction (SPME) fibers using desorption electrospray ionization mass spectrometry (DESI-MS) for the purpose of analyzing drugs from raw urine is presented. The method combines a simple, inexpensive, and solvent-less sample preparation technique with the specificity and speed of DESI-MS and MS/MS. Extraction of seven drugs from raw urine is performed using specially designed SPME fibers coated uniformly with silica-C(18) stationary phase. Each SPME device is inserted into unprocessed urine under gentle agitation and, then, removed, rinsed, and analyzed directly by DESI-MS (MS/MS). Rapid screening over a wide mass range is afforded by coupling the method with a time of flight (TOF) mass spectrometer while quantitative analysis is performed using selected reaction monitoring (SRM) using a triple quadrupole mass spectrometer. The performance of the SPME DESI-MS/MS method was evaluated by preparing calibration standards and quality control (QC) samples of the seven drug compounds from urine over a range from 20 to 1000 ng/mL, with the exception of meprobamate which was prepared from 200 to 10000 ng/mL. The calibration curves constructed for each analyte had an R(2) > 0.99. The range of precision (%CV) and accuracy values (% bias) for low QC samples was 1-11% and 3-38%, respectively. Precision and accuracy values for high QC samples range from 0.9 to 8% and -31 to -8%. Results from urine specimens of actual exposure to drugs screened using the SPME DESI-MS/MS method showed good agreement with the conventional immunoassays and GC/MS analysis. Liquid desorption of the SPME fiber followed by LC/MS/MS also showed good agreement with the SPME DESI-MS/MS method. PMID:20695439

  1. Quantifying the performance of charge-coupled devices in ambient conditions - Oral presentation

    SciTech Connect

    Dungee, Ryan

    2015-08-22

    Telescope surveys have given us a great deal of information about our universe, but the images they capture carry with them an inherent limitation. The question then is how do we take this information to the next level? The answer: the Dark Energy Spectroscopic Instrument (DESI). DESI is an instrument that will measure the distance to tens of millions of galaxies in our night sky. This information can be combined with already existing images to construct a three dimensional map of our universe providing a great deal of new opportunities for cosmological research. The DESI guidance system consists of 10 detectors called charge-coupled devices (CCDs). Each CCD is made of silicon atoms that emit electrons when struck with light, the electrons are counted and then used to reconstruct an image. But, CCDs suffer from an issue known as ‘dark current’ which are false counts that come from thermal motions of the silicon atoms. This is particularly problematic since they contribute to the uncertainty of a measurement without contributing to our signal. This causes a drop in the signal to noise ratio, a value that needs to be maximized in order to meet DESI’s high precision requirements. This summer was spent ensuring the DESI guidance system would meet its specifications. Data was collected using a CCD of the same type that would be used on DESI and the effectiveness of dark current removal was tested. Exposures were taken for a wide range of temperatures and exposure lengths and a number of dark current removal methods were implemented. While further testing is required, the initial results are quite promising and the DESI guidance system is on track to meet its specifications

  2. Comparison of Drug Distribution Images from Thin Tissue Sections Obtained Using Desorption Electrospray Ionization Tandem Mass Spectrometry and Whole-Body Autoradiography

    SciTech Connect

    Kertesz, Vilmos; Van Berkel, Gary J; Vavek, Marissa; Koeplinger, Kenneth A.; Schneider, Bradley B; Covey, Thomas R.

    2008-01-01

    Desorption electrospray ionization tandem mass spectrometry (DESI-MS/MS) and whole-body autoradiography (WBA) were used for chemical imaging of whole-body thin tissue sections of mice intravenously dosed with propranolol (7.5 mg/kg). DESI-MS/MS imaging utilized selected reaction monitoring detection performed on an AB/MDS SCIEX 4000 QTRAP mass spectrometer equipped with a prototype extended length particle discriminator interface. Propranolol images of the tissue sections using DESI-MS/MS were obtained at surface scan rates of 0.1, 0.5, 2 and 7 mm/s. Although signal decreased with increasing scan rate, useful whole-body images for propranolol were obtained from the tissues even at 7 mm/s, which required just 79 min of analysis time. Attempts to detect and image the distribution of the known propranolol metabolites were unsuccessful. Regions of the tissue sections showing the most radioactivity from WBA sections were excised and analyzed by HPLC with radiochemical detection to determine relative levels of propranolol and metabolites present. Comparison of the DESI-MS/MS signal for propranolol and the radioactivity attributed to propranolol from WBA sections indicated nominal agreement between the two techniques for the amount of propranolol in the brain, lung, and liver. Data from the kidney showed an unexplained disparity between the two techniques. The results of this study show the feasibility of using DESI-MS/MS to obtain useful chemical images of a drug in whole-body thin tissue sections following drug administration at a pharmacologically relevant level. Further optimization to improve sensitivity and enable detection of the drug metabolites will be among the requirements necessary to move DESI-MS/MS chemical imaging forward as a practical tool in drug discovery.

  3. Multistage Reactive Transmission-Mode Desorption Electrospray Ionization Mass Spectrometry.

    PubMed

    Peters, Kevin C; Comi, Troy J; Perry, Richard H

    2015-09-01

    Elucidating reaction mechanisms is important for advancing many areas of science such as catalyst development. It is often difficult to probe fast reactions at ambient conditions with high temporal resolution. In addition, systems involving reagents that cross-react require analytical methods that can minimize interaction time and specify their order of introduction into the reacting system. Here, we explore the utility of transmission mode desorption electrospray ionization (TM-DESI) for reaction monitoring by directing a microdroplet spray towards a series of meshes with micrometer-sized openings coated with reagents, an approach we call multistage reactive TM-DESI (TM (n) -DESI, where n refers to the number of meshes; n = 2 in this report). Various stages of the reaction are initiated at each mesh surface, generating intermediates and products in microdroplet reaction vessels traveling towards the mass spectrometer. Using this method, we investigated the reactivity of iron porphyrin catalytic hydroxylation of propranolol and other substrates. Our experimental results indicate that TM (n) -DESI provides the ability to spatially separate reagents and control their order of introduction into the reacting system, thereby minimizing unwanted reactions that lead to catalyst deactivation and degradation products. In addition, comparison with DESI-MS analyses (the Zare and Latour laboratories published results suggesting accessible reaction times <1 ms) of the reduction of dichlorophenolindophenol by L-ascorbic acid suggest that TM (1) -DESI can access reaction times less than 1 ms. Multiple meshes allow sequential stages of desorption/ionization per MS scan, increasing the number of analytes and reactions that can be characterized in a single experiment. PMID:26091888

  4. Desorption electrospray ionization mass spectrometry for trace analysis of agrochemicals in food.

    PubMed

    García-Reyes, Juan F; Jackson, Ayanna U; Molina-Díaz, Antonio; Cooks, R Graham

    2009-01-15

    Desorption electrospray ionization (DESI) is applied to the rapid, in situ, direct qualitative and quantitative (ultra)trace analysis of agrochemicals in foodstuffs. To evaluate the potential of DESI mass spectrometry (MS) in toxic residue testing in food, 16 representative multiclass agricultural chemicals (pesticides, insecticides, herbicides, and fungicides) were selected (namely, ametryn, amitraz, azoxystrobin, bitertanol, buprofezin, imazalil, imazalil metabolite, isofenphos-methyl, malathion, nitenpyram, prochloraz, spinosad, terbuthylazine, thiabendazole, and thiacloprid). The DESI-MS experiments were performed using 3 microL of solution spotted onto conventional smooth poly(tetrafluoroethylene) (PTFE) surfaces, with examination by MS and tandem mass spectrometry (MS/MS) using an ion trap mass spectrometer. Optimization of the spray solvent led to the use of acetonitrile/water (80:20) (v/v), with 1% formic acid. Most of the compounds tested showed remarkable sensitivity in the positive ion mode, approaching that attainable with conventional direct infusion electrospray mass spectrometry. To evaluate the potential of the proposed approach in real samples, different experiments were performed including the direct DESI-MS/MS analysis of fruit peels and also of fruit/vegetable extracts. The results proved that DESI allows the detection and confirmation of traces of agrochemicals in actual market-purchased samples. In addition, MS/MS confirmation of selected pesticides in spiked vegetable extracts was obtained at absolute levels as low as 1 pg for ametryn. Quantitation of imazalil residues was also undertaken using an isotopically labeled standard. The data obtained were in agreement with those from the liquid chromatography mass spectrometry (LC-MS) reference method, with relative standard deviation (RSD) values consistently below 15%. The results obtained demonstrate the sensitivity of DESI as they meet the stringent European Union pesticide regulation

  5. Production and test results of SC 3.9-GHz accelerating cavity at Fermilab

    SciTech Connect

    Khabiboulline, Timergali; Cooper, Charlie; Edwards, Helen; Foley, Mike; Gonin, Ivan; Mitchell, Donald; Olis, D.; Rowe, Allan; Salman, Tariq; Solyak, Nikolay; /Fermilab

    2006-08-01

    The 3rd harmonic 3.9GHz accelerating cavity was proposed to improve beam performances for TTF-FEL facility. In the frame of collaboration Fermilab will provide DESY with a cryomodule containing a string of four cavities. In addition, a second cryomodule with one cavity will be fabricated for installation in the Fermilab photo-injector, which will be upgraded for the ILC accelerator test facility. In this paper we discuss the status of the cavity and coupler production and the first result of cavity tests. It is hoped that this project will be completed during the first half of 2007 and the cryomodule delivered to DESY in this time span.

  6. Testing an e2v CCD230-42 sensor for dark current performance at ambient temperatures - Final Paper

    SciTech Connect

    Dungee, Ryan

    2015-08-20

    The design of the Guidance Focus and Alignment (GFA) system for the Dark Energy Spectroscopic Instrument (DESI) project calls for a set of charge-coupled devices (CCDs) which operate at ambient temperature. Here we assess the performance of these CCDs under such conditions. Data was collected from –21°C to 28°C and used to determine the effect of temperature on the effectiveness of dark current subtraction. Comparing the dark current uncertainty to our expected signal has shown that the DESI design specifications will be met without need for significant changes.

  7. Project summary

    SciTech Connect

    Dungee, Ryan

    2015-08-22

    Telescope surveys have given us a great deal of information about our universe, but the images they capture carry with them an inherent limitation. The question then is how do we take this information to the next level? The answer: the Dark Energy Spectroscopic Instrument (DESI). DESI is an instrument that will measure the distance to tens of millions of galaxies in our night sky. This information can be combined with already existing images to construct a three dimensional map of our universe providing a great deal of new opportunities for cosmological research.

  8. Desorption electrospray ionization imaging of small organics on mineral surfaces.

    PubMed

    Bennett, Rachel V; Fernández, Facundo M

    2015-01-01

    Desorption electrospray ionization (DESI)-mass spectrometry facilitates the ambient chemical analysis of a variety of surfaces. Here we describe the protocol for using DESI imaging to measure the distributions of small prebiotically relevant molecules on granite surfaces. Granites that contain a variety of juxtaposed mineral species were reacted with formamide in order to study the role of local mineral environment on the production of purines and pyrimidines. The mass spectrometry imaging (MSI) methods described here can also be applied to the surface analysis of rock samples involved in other applications such as petroleum or environmental chemistries. PMID:25361668

  9. Spectral radiance calibrations between 165-300 nm - An interlaboratory comparison

    NASA Technical Reports Server (NTRS)

    Bridges, J. M.; Ott, W. R.; Pitz, E.; Schulz, A.; Einfeld, D.; Stuck, D.

    1977-01-01

    The spectral radiance of deuterium lamps calibrated by the Max-Planck-Institut fuer Astronomie (MPI), by the U.S. National Bureau of Standards (NBS), and by the Physikalisch-Technische Bundesanstalt (PTB) are compared to check the agreement of UV radiometric scales. The NBS group used the optically thin continuum radiation from a wall-stabilized hydrogen arc as its fundamental radiometric standard, while the MPI and PTB groups used the synchrotron radiation facility in DESY. It is found that the spectral radiance scales based upon the DESY synchrotron and the NBS hydrogen arc are consistent, at least for one wavelength relative to another.

  10. Detection of the short-lived radical cation intermediate in the electrooxidation of N,N-dimethylaniline by mass spectrometry.

    PubMed

    Brown, Timothy A; Chen, Hao; Zare, Richard N

    2015-09-14

    The N,N-dimethylaniline (DMA) radical cation DMA(.+) , a long-sought transient intermediate, was detected by mass spectrometry (MS) during the electrochemical oxidation of DMA. This was accomplished by coupling desorption electrospray ionization (DESI) MS with a waterwheel working electrode setup to sample the surface of the working electrode during electrochemical analysis. This study clearly shows that DESI-based electrochemical MS is capable of capturing electrochemically generated intermediates with half-lives on the order of microseconds, which is 4-5 orders of magnitude faster than previously reported electrochemical mass spectrometry techniques. PMID:26352029

  11. Social Bookmarking am Beispiel BibSonomy

    NASA Astrophysics Data System (ADS)

    Hotho, Andreas; Jäschke, Robert; Benz, Dominik; Grahl, Miranda; Krause, Beate; Schmitz, Christoph; Stumme, Gerd

    BibSonomy ist ein kooperatives Verschlagwortungssystem (Social Bookmarking System), betrieben vom Fachgebiet Wissensverarbeitung der Universität Kassel. Es erlaubt das Speichern und Organisieren von Web-Lesezeichen und Metadaten für wissenschaftliche Publikationen. In diesem Beitrag beschreiben wir die von BibSonomy bereitgestellte Funktionalität, die dahinter stehende Architektur sowie das zugrunde liegende Datenmodell. Ferner erläutern wir Anwendungsbeispiele und gehen auf Methoden zur Analyse der in BibSonomy und ähnlichen Systemen enthaltenen Daten ein.

  12. Desorption ElectroSpray Ionization - Orbitrap Mass Spectrometry of synthetic polymers and copolymers.

    PubMed

    Friia, Manel; Legros, Véronique; Tortajada, Jeanine; Buchmann, William

    2012-08-01

    Desorption ElectroSpray Ionization (DESI) - Orbitrap Mass Spectrometry (MS) was evaluated as a new tool for the characterization of various industrial synthetic polymers (poly(ethylene glycol), poly(propylene glycol), poly(methylmethacrylate), poly(dimethylsiloxane)) and copolymers, with masses ranging from 500 g.mol(-1) up to more than 20 000 g.mol(-1) . Satisfying results in terms of signal stability and sensitivity were obtained from hydrophobic surfaces (HTC Prosolia) with a mixture water/methanol (10/90) as spray solvent in the presence of sodium salt. Taking into account the formation of multiplied charged species by DESI-MS, a strategy based on the use of a deconvolution software followed by the automatic assignment of the ions was described allowing the rapid determination of M(n) , M(w) and PDI values. DESI-Orbitrap MS results were compared to those obtained from matrix-assisted laser desorption/ionization- time-of-flight MS and gel permeation chromatography. An application of DESI-Orbitrap MS for the detection and identification of polymers directly from cosmetics was described. PMID:22899511

  13. Direct analysis of ethylenediaminetetraacetic acid (EDTA) on concrete by reactive-desorption electrospray ionization mass spectrometry.

    PubMed

    Lebeau, D; Reiller, P E; Lamouroux, C

    2015-01-01

    Analysis of organic ligands such as ethylenediaminetetraacetic acid (EDTA) is today an important challenge due to their ability to increase the mobility of radionuclides and metals. Reactive desorption electrospray ionization mass spectrometry (reactive-DESI-MS) was used for direct analysis of EDTA on concrete samples. EDTA forms complexes and those with Fe(III) ions are among the most thermodynamically favored. This complexing capacity was used to improve the specific detection of EDTA directly on a concrete matrix by doping the solvent spray of DESI with a solution of FeCl3 to selectively create the complex between EDTA and Fe(III). Thus, EDTA sensitivity was largely improved by two orders of magnitude with reactive-DESI-MS experiments thanks to the specific detection of EDTA as a [EDTA-4H+Fe(III)](-) complex. The proof of principle that reactive DESI can be applied to concrete samples to detect EDTA has been demonstrated. Its capacity for semi-quantitative determination and localization of EDTA under ambient conditions and with very little sample preparation, minimizing sample manipulations and solvent volumes, two important conditions for the development of new methodologies in the field of analytical chemistry, has been shown. PMID:25476391

  14. The bench scientist's guide to RNA-Seq analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    RNA sequencing (RNA-Seq) is emerging as a highly accurate method to quantify transcript abundance. However, analyses of the large data sets obtained by sequencing the entire transcriptome of organisms have generally been performed by bioinformatic specialists. Here we outline a methods strategy desi...

  15. High-Resolution Desorption Electrospray Ionization Mass Spectrometry for Chemical Characterization of Organic Aerosols

    SciTech Connect

    Laskin, Julia; Laskin, Alexander; Roach, Patrick J.; Slysz, Gordon W.; Anderson, Gordon A.; Nizkorodov, Serguei; Bones, David L.; Nguyen, Lucas

    2010-03-01

    Characterization of the chemical composition and chemical transformations of secondary organic aerosol (SOA) is both a major challenge and the area of greatest uncertainty in current aerosol research. This study presents the first application of desorption electrospray ionization combined with high-resolution mass spectrometry (DESI-MS) for detailed chemical characterization and studies of chemical aging of OA collected on Teflon substrates. DESI-MS offers unique advantages both for detailed characterization of chemically labile components in OA that cannot be detected using more traditional electrospray ionization mass spectrometry (ESI-MS) and for studying chemical aging of OA. DESI-MS enables rapid characterization of OA samples collected on substrates by eliminating the sample preparation stage. In addition, it enables detection and structural characterization of chemically labile molecules in OA samples by minimizing the residence time of analyte in the solvent. SOA produced by the ozonolysis of limonene (LSOA) was allowed to react with gaseous ammonia. Chemical aging resulted in measurable changes in the optical properties of LSOA observed using UV- visible spectroscopy. DESI-MS combined with tandem mass spectrometry experiments (MS/MS) enabled identification of species in aged LSOA responsible for absorption of the visible light. Detailed analysis of the experimental data allowed us to identify chemical changes induced by reactions of LSOA constituents with ammonia and distinguish between different mechanisms of chemical aging.

  16. Common HEP UNIX Environment

    NASA Astrophysics Data System (ADS)

    Taddei, Arnaud

    After it had been decided to design a common user environment for UNIX platforms among HEP laboratories, a joint project between DESY and CERN had been started. The project consists in 2 phases: 1. Provide a common user environment at shell level, 2. Provide a common user environment at graphical level (X11). Phase 1 is in production at DESY and at CERN as well as at PISA and RAL. It has been developed around the scripts originally designed at DESY Zeuthen improved and extended with a 2 months project at CERN with a contribution from DESY Hamburg. It consists of a set of files which are customizing the environment for the 6 main shells (sh, csh, ksh, bash, tcsh, zsh) on the main platforms (AIX, HP-UX, IRIX, SunOS, Solaris 2, OSF/1, ULTRIX, etc.) and it is divided at several "sociological" levels: HEP, site, machine, cluster, group of users and user with some levels which are optional. The second phase is under design and a first proposal has been published. A first version of the phase 2 exists already for AIX and Solaris, and it should be available for all other platforms, by the time of the conference. This is a major collective work between several HEP laboratories involved in the HEPiX-scripts and HEPiX-X11 working-groups.

  17. Irrigation Water and Nitrate Loss Characterization in South Florida Nurseries: Cumulative Volumes, Runoff Rates, NO3-N Concentrations and Loadings, and Implications for Management

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Enrichment of surface water with nitrate-nitrogen is a significant problem throughout the world. In support of developing a method for removing nitrate from water using denitrification, this project characterized runoff events at two nurseries in South Florida to provide information needed for desi...

  18. Desorption Electrospray Ionization Mass Spectrometry Reveals Lipid Metabolism of Individual Oocytes and Embryos

    PubMed Central

    González-Serrano, Andrés Felipe; Pirro, Valentina; Ferreira, Christina R.; Oliveri, Paolo; Eberlin, Livia S.; Heinzmann, Julia; Lucas-Hahn, Andrea; Niemann, Heiner; Cooks, Robert Graham

    2013-01-01

    Alteration of maternal lipid metabolism early in development has been shown to trigger obesity, insulin resistance, type 2 diabetes and cardiovascular diseases later in life in humans and animal models. Here, we set out to determine (i) lipid composition dynamics in single oocytes and preimplantation embryos by high mass resolution desorption electrospray ionization mass spectrometry (DESI-MS), using the bovine species as biological model, (ii) the metabolically most relevant lipid compounds by multivariate data analysis and (iii) lipid upstream metabolism by quantitative real-time PCR (qRT-PCR) analysis of several target genes (ACAT1, CPT 1b, FASN, SREBP1 and SCAP). Bovine oocytes and blastocysts were individually analyzed by DESI-MS in both positive and negative ion modes, without lipid extraction and under ambient conditions, and were profiled for free fatty acids (FFA), phospholipids (PL), cholesterol-related molecules, and triacylglycerols (TAG). Principal component analysis (PCA) and linear discriminant analysis (LDA), performed for the first time on DESI-MS fused data, allowed unequivocal discrimination between oocytes and blastocysts based on specific lipid profiles. This analytical approach resulted in broad and detailed lipid annotation of single oocytes and blastocysts. Results of DESI-MS and transcript regulation analysis demonstrate that blastocysts produced in vitro and their in vivo counterparts differed significantly in the homeostasis of cholesterol and FFA metabolism. These results should assist in the production of viable and healthy embryos by elucidating in vivo embryonic lipid metabolism. PMID:24073231

  19. C4 grasses prosper as carbon dioxide eliminates desiccation in warmed semi-arid grasslands

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Global warming is predicted to induce desiccation in many world regions through increases in evaporative demand. Rising CO2 may counter that trend by improving plant water use efficiency (WUE). However, it is not clear how important this CO2-enhanced WUE might be in off-setting warming-induced desi...

  20. Spin Physics at HERMES

    SciTech Connect

    Hasch, D.

    2007-06-13

    The HERMES experiment at DESY is a second generation experiment to study the spin structure of the nucleon by measuring not only inclusive but also semi-inclusive and exclusive processes in deep-inelastic lepton scattering. An overview of most recent results is given.

  1. Registration of ‘Ok102’ Wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ‘Ok102’ (Reg. no. CV-941, PI 632635) is a hard red winter wheat (Triticum aestivum L.) developed cooperatively by the Oklahoma Agric. Exp. Stn. and the USDA-ARS. Ok102 was released in March 2002, primarily on the basis of its resistance to several foliar diseases, excellent milling quality, and desi...

  2. CHILDREN'S ENVIRONMENTAL HEALTH RESEARCH - EPA AND DHHS COLLABORATE TO ADDRESS LONG-TERM HEALTH ISSUES

    EPA Science Inventory

    Children's environmental health is important to the mission of both the U.S. Department of Health and Human Services (DHHS) and the U.S. Environmental Protection Agency (EPA). Over the past seven years, federal experts from a variety of disciplines including survey sampling desi...

  3. REVEGETATING RUSSIAN KNAPWEED INFESTATIONS USING MORPHOLOGICALLLY DIVERSE SPECIES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Highly degraded pastures and rangeland dominated by Russian knapweed (Acroptilon repens [L.] DC) are often devoid of desirable plants. Control efforts may be ephemeral because propagules of desirable species are not available to reoccupy niches made available by control procedures. Establishing desi...

  4. System-Events Toolbox--Activating Urban Places for Social Cohesion through Designing a System of Events That Relies on Local Resources

    ERIC Educational Resources Information Center

    Fassi, Davide; Motter, Roberta

    2014-01-01

    This paper is a reflection on the use of public spaces in towns and the development of a system-events toolbox to activate them towards social cohesion. It is the result of a 1 year action research developed together with POLIMI DESIS Lab of the Department of Design to develop design solutions to open up the public spaces of the campus to the…

  5. 78 FR 70027 - Senior Executive Service; Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    .... ANDERSON, CYNTHIA V. ANDERSON, ROBERT T. ANDREWS, CLAUDIA R. AOKI, STEVEN NMN ARANGO III, JOSEPH NMN..., TRACEY L. BLACK, STEVEN K. BOARDMAN, KAREN L. BODI, F. LORRAINE BOLTON JR. EDWARD L. BORGSTROM, CAROL M... R. CRAWFORD, GLEN D. CRESCENZO, FRANK J. CROUTHER, DESI A. CROWELL, BRADLEY R. CUGINI, ANTHONY...

  6. Effects of bale feeder type and supplementation of monensin on hay waste, intake, and performance of beef cattle

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effects of feeder type and supplemental monensin on hay utilization in beef cows was investigated using 56 crossbred beef cows (BW= 494 ± 50 kg; BCS= 5.2 ± 0.5) in a split-plot treatment arrangement with a completely randomized design. Supplement treatment served as the main plot and feeder desi...

  7. Transient decrements in mood during energy deficit are independent of dietary protein-to-carbohydrate ratio

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Energy deficit and dietary macronutrient intake are thought to independently modulate cognition, mood and sleep. To what extent manipulating the dietary ratio of protein-to-carbohydrate affects mood, cognition and sleep during short-term energy deficit is undetermined. Using a randomized, block desi...

  8. 76 FR 1174 - Drugs for Human Use; Drug Efficacy Study Implementation; Oral Prescription Drugs Offered for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... and other parties in response to various DESI notices covering relevant products. \\3\\ 38 FR 34481 (December 14, 1973). \\4\\ 38 FR 4006 (February 9, 1973) and 37 FR 15022 (July 27, 1972). All drugs covered by... Federal Register on May 25, 1982 (47 FR 22606), FDA revoked the temporary exemption that permitted...

  9. Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging.

    PubMed

    Eberlin, Livia S; Tibshirani, Robert J; Zhang, Jialing; Longacre, Teri A; Berry, Gerald J; Bingham, David B; Norton, Jeffrey A; Zare, Richard N; Poultsides, George A

    2014-02-18

    Surgical resection is the main curative option for gastrointestinal cancers. The extent of cancer resection is commonly assessed during surgery by pathologic evaluation of (frozen sections of) the tissue at the resected specimen margin(s) to verify whether cancer is present. We compare this method to an alternative procedure, desorption electrospray ionization mass spectrometric imaging (DESI-MSI), for 62 banked human cancerous and normal gastric-tissue samples. In DESI-MSI, microdroplets strike the tissue sample, the resulting splash enters a mass spectrometer, and a statistical analysis, here, the Lasso method (which stands for least absolute shrinkage and selection operator and which is a multiclass logistic regression with L1 penalty), is applied to classify tissues based on the molecular information obtained directly from DESI-MSI. The methodology developed with 28 frozen training samples of clear histopathologic diagnosis showed an overall accuracy value of 98% for the 12,480 pixels evaluated in cross-validation (CV), and 97% when a completely independent set of samples was tested. By applying an additional spatial smoothing technique, the accuracy for both CV and the independent set of samples was 99% compared with histological diagnoses. To test our method for clinical use, we applied it to a total of 21 tissue-margin samples prospectively obtained from nine gastric-cancer patients. The results obtained suggest that DESI-MSI/Lasso may be valuable for routine intraoperative assessment of the specimen margins during gastric-cancer surgery. PMID:24550265

  10. AN INDICATOR OF POTENTIAL STREAM WOOD CONTRIBUTION FOR RIPARIAN FORESTS

    EPA Science Inventory

    In northwestern Oregon a key function of riparian forests is to provide wood to the stream network. This function is a prominent feature of Federal and State forest practices in the region. Thus, defining indicators which are associated with this function are important for desi...

  11. Garbanzo diet lowers cholesterol in hamsters

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cholesterol-lowering potential of diets with 22% protein from Chickpea (Cicer arietinum, European variety of Garbanzo, Kabuli Chana), Bengal gram (Cicer arietinum, Asian variety of Garbanzo, Desi Chana, smaller in size, yellow to black color), lentils, soy protein isolate, hydrolyzed salmon protein...

  12. EMAP - WEST COMMUNICATIONS, SURVEY DESIGNS FOR SAMPLING SURFACE WATER CONDITION IN THE WEST (ONE-PAGE BRIEFING PAPER ON EMAP-WEST ACTIVITIES)

    EPA Science Inventory

    To meet the requirements of the Clean Water Act, States and Tribes must provide a statement of condition of their surface water resources. The design used in EMAP-West will allow these
    requirements to be met in an efficient as well as scientifically defensible manner. The desi...

  13. Simple sequence repeat markers that identify Claviceps species and strains

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Claviceps purpurea is a pathogen that infects most members of the Pooideae subfamily and causes ergot, a floral disease in which the ovary is replaced with a sclerotium. This study was initiated to develop Simple Sequence Repeat (SSRs) markers for rapid identification of C. purpurea. SSRs were desi...

  14. Light at the end of the tunnel for European X-ray lab

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2012-04-01

    Construction of the 2.1 km tunnel for the European X-ray Free Electron Laser (European XFEL) at the DESY lab in Hamburg was completed last month and engineers are already moving in lighting, cable trays and smoke detectors.

  15. SYSTEMS APPROACH TO RECOVERY AND REUSE OF ORGANIC MATERIAL FLOWS IN SANTA BARBARA COUNTY TO EXTRACT MAXIMUM VALUE AND ELIMINATE WASTE

    EPA Science Inventory

    The goal of the project is to calculate the net social, environmental, and economic benefits of a systems approach to organic waste and resource management in Santa Barbara County. To calculate these benefits, a comparative method was chosen of the proposed desi...

  16. East Indian Families Raising ABCD Adolescents: Cultural and Generational Challenges

    ERIC Educational Resources Information Center

    Poulsen, Shruti S.

    2009-01-01

    Immigration is a process fraught with both challenges and opportunities for families. In particular, East Indian families with U.S.-born adolescents experience the challenges of bridging cultures across generational divides; they are perceived by others as confused, identity less, and conflicted or as American-Born, Confused Desis (ABCDs). This…

  17. 75 FR 36419 - Determination That DELALUTIN (hydroxyprogesterone caproate) Injection, 125 Milligrams/Milliliter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... (DESI) program. In the Federal Register of September 9, 1971 (36 FR 18115), FDA announced that... classified as effective or probably effective. In the Federal Register of October 10, 1973 (38 FR 27947), FDA...).'' In the Federal Register of July 22, 1977 (42 FR 37646), FDA stated that reports during the...

  18. DESIGN CONSIDERATIONS FOR THE MECHANICAL TUNER OF THE RHIC ELECTRON COOLER RF CAVITY.

    SciTech Connect

    RANK, J.; BEN-ZVI,I.; HAHN,G.; MCINTYRE,G.; DALY,E.; PREBLE,J.

    2005-05-16

    The ECX Project, Brookhaven Lab's predecessor to the RHIC e-Cooler, includes a prototype RF tuner mechanism capable of both coarse and fast tuning. This tuner concept, adapted originally from a DESY design, has longer stroke and significantly higher loads attributable to the very stiff ECX cavity shape. Structural design, kinematics, controls, thermal and RF issues are discussed and certain improvements are proposed.

  19. A New Splitting Method for Both Analytical and Preparative LC/MS

    NASA Astrophysics Data System (ADS)

    Cai, Yi; Adams, Daniel; Chen, Hao

    2013-11-01

    This paper presents a novel splitting method for liquid chromatography/mass spectrometry (LC/MS) application, which allows fast MS detection of LC-separated analytes and subsequent online analyte collection. In this approach, a PEEK capillary tube with a micro-orifice drilled on the tube side wall is used to connect with LC column. A small portion of LC eluent emerging from the orifice can be directly ionized by desorption electrospray ionization (DESI) with negligible time delay (6~10 ms) while the remaining analytes exiting the tube outlet can be collected. The DESI-MS analysis of eluted compounds shows narrow peaks and high sensitivity because of the extremely small dead volume of the orifice used for LC eluent splitting (as low as 4 nL) and the freedom to choose favorable DESI spray solvent. In addition, online derivatization using reactive DESI is possible for supercharging proteins and for enhancing their signals without introducing extra dead volume. Unlike UV detector used in traditional preparative LC experiments, this method is applicable to compounds without chromophores (e.g., saccharides) due to the use of MS detector. Furthermore, this splitting method well suits monolithic column-based ultra-fast LC separation at a high elution flow rate of 4 mL/min. [Figure not available: see fulltext.

  20. 15 CFR 711.8 - How to request authorization from BIS to make electronic submissions of declarations or reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... passwords for facilities, plant sites and trading companies (USC password) and Web-DESI user accounts (user name and password). (i) Each person, facility, plant site or trading company authorized to submit declarations and reports electronically will be assigned a password (USC password) that must be used...

  1. 15 CFR 711.8 - How to request authorization from BIS to make electronic submissions of declarations or reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... passwords for facilities, plant sites and trading companies (USC password) and Web-DESI user accounts (user name and password). (i) Each person, facility, plant site or trading company authorized to submit declarations and reports electronically will be assigned a password (USC password) that must be used...

  2. 15 CFR 711.8 - How to request authorization from BIS to make electronic submissions of declarations or reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... passwords for facilities, plant sites and trading companies (USC password) and Web-DESI user accounts (user name and password). (i) Each person, facility, plant site or trading company authorized to submit declarations and reports electronically will be assigned a password (USC password) that must be used...

  3. 15 CFR 711.8 - How to request authorization from BIS to make electronic submissions of declarations or reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... passwords for facilities, plant sites and trading companies (USC password) and Web-DESI user accounts (user name and password). (i) Each person, facility, plant site or trading company authorized to submit declarations and reports electronically will be assigned a password (USC password) that must be used...

  4. 75 FR 16001 - New Animal Drugs; Removal of Obsolete and Redundant Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ....hhs.gov . SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of August 8, 2003 (68 FR... Study Implementation (DESI) program (68 FR 47332). CVM proposed to withdraw the new animal drug.... In that final rule (71 FR 16219, March 31, 2006), FDA removed from the tables in Sec....

  5. Assessing the Contribution of Vocational Education to Basic Education in Secondary Schools.

    ERIC Educational Resources Information Center

    Hotchkiss, Lawrence; Desy, Jeanne

    This report examines the contribution of secondary vocational education to learning outcomes. It is targeted to research scholars with professional interests related to vocational education, effective schooling, learning, and methodology. The first of six chapters is an "Introduction" (Lawrence Hotchkiss, Jeanne Desy). "The Effects of Vocational…

  6. NATIONAL LAKE ASSESSMENT MONITORING DESIGN

    EPA Science Inventory

    The USEPA designed the National Lake Assessment in 2005-6 with field sampling being completed in 2007. The objective of the assessment is to estimate the ecological condition of lakes and reservoirs nationally. The objective of this paper is to describe the national survey desi...

  7. Stream and River Condition Across the BLM's National System of Public Lands.

    EPA Science Inventory

    The Bureau of Land Management (BLM), in collaboration with the U.S. Environmental Protection Agency, conducted the first ever Western Rivers and Streams Assessment (WRSA), a survey of the condition of BLM streams and rivers throughout the contiguous western U.S. The WRSA was desi...

  8. A search for the lepton-flavour violating decays τ → eα, τ → μα

    NASA Astrophysics Data System (ADS)

    Albrecht, H.; Hamacher, T.; Hofmann, R. P.; Kirchhoff, T.; Mankel, R.; Nau, A.; Nowak, S.; Reßing, D.; Schröder, H.; Schulz, H. D.; Walter, M.; Wurth, R.; Hast, C.; Kapitza, H.; Kolanoski, H.; Kosche, A.; Lange, A.; Lindner, A.; Schieber, M.; Siegmund, T.; Spaan, B.; Thurn, H.; Töpfer, D.; Wegener, D.; Eckstein, P.; Frankl, C.; Graf, J.; Schmidtler, M.; Schramm, M.; Schubert, K. R.; Schwierz, R.; Waldi, R.; Reim, K.; Wegener, H.; Eckmann, R.; Kuipers, H.; Mai, O.; Mundt, R.; Oest, T.; Reiner, R.; Schmidt-Parzefall, W.; Stiewe, J.; Werner, S.; Ehret, K.; Hofmann, W.; Hüpper, A.; Knöpfle, K. T.; Spengler, J.; Kreger, P.; Macfarlane, D. B.; Prentice, J. D.; Saull, P. R. B.; Tzamariudaki, K.; van de Water, R. G.; Yoon, T.-S.; Schneider, M.; Weseler, S.; Kernel, G.; Križnič, P.; Podobnik, T.; Živko, T.; Balagura, V.; Barsuk, S.; Belyaev, I.; Chistov, R.; Danilov, M.; Eiges, V.; Gershtein, L.; Gershtein, Yu.; Golutvin, A.; Igonkina, O.; Korolko, I.; Kostina, G.; Litvintsev, D.; Pakhlov, P.; Semenov, S.; Snizhko, A.; Tichomirov, I.; Zaitsev, Yu.

    1995-03-01

    Lepton spectra in τ decays have been studied with the ARGUS detector at the e + e - storage ring DORIS II at DESY using the “pseudo-rest-frame” technique. We have improved upper limits for two-body τ-decays into a lepton and an unobservable particle.

  9. Review of studies on conventional linear colliders in the S- and X-Band regime

    SciTech Connect

    Loew, G.A.

    1992-07-01

    This paper gives a status report on the conventional approaches to linear colliders at DESY, KEK, SLAC and INP-Protvino in the S- and X-Band regime. Critical topics are reviewed and a discussion of global issues such as future R&D requirements is included.

  10. Review of studies on conventional linear colliders in the S- and X-Band regime

    SciTech Connect

    Loew, G.A.

    1992-07-01

    This paper gives a status report on the conventional approaches to linear colliders at DESY, KEK, SLAC and INP-Protvino in the S- and X-Band regime. Critical topics are reviewed and a discussion of global issues such as future R D requirements is included.

  11. TESLA FEL Gun simulations with PARMELA and MAFIA

    NASA Astrophysics Data System (ADS)

    Zhang, Min; Schuett, Petra

    1997-02-01

    The most recent simulation results of the DESY TESLA FEL gun are presented. Two codes are used: PARMELA and MAFIA. Since the two use different schemes in particle simulations, we will address their differences and try to give an explanation for them.

  12. Desorption electrospray ionization mass spectrometry: direct toxicological screening and analysis of illicit Ecstasy tablets.

    PubMed

    Leuthold, Luc Alexis; Mandscheff, Jean-François; Fathi, Marc; Giroud, Christian; Augsburger, Marc; Varesio, Emmanuel; Hopfgartner, Gérard

    2006-01-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) was used as a simple and rapid way to analyze drug tablets and powders without sample preparation. Experiments were performed with a home-made DESI source coupled to a triple-quadrupole linear-ion trap (QqQ(LIT)) mass spectrometer. Twenty-one commercial drugs as well as some illicit Ecstasy tablets and powders were analyzed. MS spectra almost exclusively showed the protonated or deprotonated ion of the drug after directing the pneumatically assisted electrospray onto the tablet's surface. With some tablets, inhomogeneity of the surface resulted in different spectra depending on the spot analyzed, thus showing that DESI could be used for imaging. Directly triggered MS/MS spectra were used for confirmatory analysis, with analysis times often below 10 s per tablet. For illicit Ecstasy tablets, DESI-MS, GC/MS and LC/MS analyses provided similar qualitative results for the main analytes. With MS/MS spectra library comparison or exact mass measurements, this technique could become very powerful for the rapid analysis of unknown tablets and shows the great potential of desorption techniques as an alternative to solution-based analysis. PMID:16331738

  13. Association Between Yield, Yield Components, and Fiber Properties Exotic Germplasm Derived from Multiple Crosses Between Gossypium hirsutum and G. barbadense

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Broadening genetic base is essential for genetic improvement of lint yield and fiber quality in upland cotton. An exotic germplasm population derived from multiple crosses between Gossypium barbadense L. and Acala 1517 types was obtained from USDA-ARS at Las Cruces, NM, USA. This germplasm was desi...

  14. Chemical Analysis of Organic Aerosols Using Reactive Nanospray Desorption Electrospray Ionization Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Laskin, A.; Laskin, J.; Nizkorodov, S.

    2013-12-01

    Nanospray Desorption Electrospray Ionization (nano-DESI) technique integrated with high resolution mass spectrometry (HR-MS) enables molecular level analysis of organic aerosol (OA) samples. In nano-DESI, analyte is desorbed into a small volume solvent bridge formed between two capillaries positioned in contact with analyte and enables fast and efficient characterization of OA collected on substrates without sample preparation. We report applications of the nano-DESI/HR-MS approach in a number of our recent studies focused on molecular identification of organic compounds in laboratory and in field collected OA samples. Reactive nano-DESI approach where selected reagent is added to the solvent is used for examining the presence of individual species containing specific functional groups and for their quantification within complex mixtures of OA. Specifically, we use the Girard's reagent T (GT) to probe and quantify carbonyl compounds in the SOA mixtures. We estimate for the first time the amounts of dimers and trimers in the SOA mixtures. We found that the most abundant dimer in limonene/O3 SOA was detected at the ˜0.5 pg level and the total amount of dimers and trimers in the analyzed sample was ˜11 pg. Understanding of the OA composition at the molecular level allowed us to identify key aging reactions, including the transformation of carbonyls to imines and carbonyl-imine oligomerization, that may contribute to the formation of brown carbon in the atmosphere.

  15. Rapid detection of terbufos in stomach contents using desorption electrospray ionization mass spectrometry.

    PubMed

    Wilson, Christina R; Mulligan, Christopher C; Strueh, Kurt D; Stevenson, Gregory W; Hooser, Stephen B

    2014-03-26

    Desorption electrospray ionization mass spectrometry (DESI-MS) is an emerging analytical technique that permits the rapid and direct analysis of biological or environmental samples under ambient conditions. Highlighting the versatility of this technique, DESI-MS has been used for the rapid detection of illicit drugs, chemical warfare agents, agricultural chemicals, and pharmaceuticals from a variety of sample matrices. In diagnostic veterinary toxicology, analyzing samples using traditional analytical instrumentation typically includes extensive sample extraction procedures, which can be time consuming and labor intensive. Therefore, efforts to expedite sample analyses are a constant goal for diagnostic toxicology laboratories. In the current report, DESI-MS was used to directly analyze stomach contents from a dog exposed to the organophosphate insecticide terbufos. The total DESI-MS analysis time required to confirm the presence of terbufos and diagnose organophosphate poisoning in this case was approximately 5 min. This highlights the potential of this analytical technique in the field of veterinary toxicology for the rapid diagnosis and detection of toxicants in biological samples. PMID:24670950

  16. LONG PATH LASER OZONE MONITOR EVALUATION

    EPA Science Inventory

    The purpose of the study reported here was to evaluate a long path laser air pollution monitor developed for the U.S. Environmental Protection Agency (EPA) by the General Electric (GE) Company. The monitor was known as ILAMS (Infrared Laser Atmospheric Monitoring System) and desi...

  17. INDOOR AIR QUALITY AND INHALATION EXPOSURE - SIMULATION TOOL KIT

    EPA Science Inventory

    A Microsoft Windows-based indoor air quality (IAQ) simulation software package is presented. Named Simulation Tool Kit for Indoor Air Quality and Inhalation Exposure, or IAQX for short, this package complements and supplements existing IAQ simulation programs and is desi...

  18. Four Decades of Computing in Subnuclear Physics - from Bubble Chamber to LHC

    NASA Astrophysics Data System (ADS)

    Knobloch, Jürgen

    2014-06-01

    This manuscript addresses selected aspects of computing for the reconstruction and simulation of particle interactions in subnuclear physics. Based on personal experience with experiments at DESY and at CERN, I cover the evolution of computing hardware and software from the era of track chambers where interactions were recorded on photographic film up to the LHC experiments with their multi-million electronic channels.

  19. On the identity of European Baridini (Coleoptera, Curculionoidea) named before 1832

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Twenty-eight names of European weevils usually regarded as Baridini in the literature are checked. Neotypes are designated for Curculio coerulescens Scopoli 1763 (emend.), C. glaber Herbst 1784, C. chalybeus Gmelin 1790, C. laticollis Marsham 1802, and C. picicornis Marsham 1802. Lectotypes are desi...

  20. Effects of Early Serotonin Programming on Fear Response, Memory and Aggression

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The neurotransmitter serotonin (5-HT) also acts as a neurogenic compound in the developing brain. Early administration of a 5-HT agonist could alter development of serotonergic circuitry, altering behaviors mediated by 5-HT signaling, including memory, fear and aggression. The present study was desi...

  1. Mapping the biological condition of USA rivers and streams

    EPA Science Inventory

    We predicted the probable (pr) biological condition (BC) of ~5.4 million km of stream within the conterminous USA (CONUS). National maps of prBC could provide an important tool for prioritizing monitoring and restoration of streams. The USEPA uses a spatially balanced survey desi...

  2. DEVELOPMENTAL TOXICITY OF ATRAZINE METABOLITES IN FISCHER 344 RATS

    EPA Science Inventory

    Previously we have shown that atrazine, a commonly used herbicide, causes full-litter resorption (FLR) in Fischer 344 rats at 50 mg/kg. In this study, we tested four atrazine metabolites for their potential to cause FLR and developmental toxicity. Desethylatrazine (DEA), desis...

  3. On-probe atmospheric pressure thermal desorption-ESI-MS for the analysis of volatile analytes or volatile pryolysis products

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An on-probe pyrolyzer has been constructed and interfaced with desorption electrospray ionization (DESI) mass spectrometry (MS) for the rapid analysis of non-volatile pyrolysis products. The detection and analysis of non-volatile pyrolysis products of peptides, proteins and the synthetic polymer pol...

  4. Current and Emerging Water Distribution Main Renewal Technologies

    EPA Science Inventory

    The funding needed to address aging underground infrastructure renewals range as high as $325 billion over the next 20 years and with the current annual replacement rate at 0.5%, pipes are being expected to last for 200 years, which is unreasonable considering most pipes are desi...

  5. PHYTOREMEDIATION OF DREDGED SEDIMENTS: A CASE STUDY AT THE JONES ISLAND CDF

    EPA Science Inventory

    The Jones Island Confined Disposal Facility (CDF) is a 44 acre in-lake area that receives dredged material from Milwaukee Harbor and the surrounding waterways. Some of those materials are contaminated with industrial waste and urban run-off. The CDF is nearing the end of its desi...

  6. Analysis of colorectal adenocarcinoma tissue by desorption electrospray ionization mass spectrometric imaging.

    PubMed

    Gerbig, Stefanie; Golf, Ottmar; Balog, Julia; Denes, Julia; Baranyai, Zsolt; Zarand, Attila; Raso, Erzsebet; Timar, Jozsef; Takats, Zoltan

    2012-06-01

    Negative ion desorption electrospray ionization (DESI) was used for the analysis of an ex vivo tissue sample set comprising primary colorectal adenocarcinoma samples and colorectal adenocarcinoma liver metastasis samples. Frozen sections (12 μm thick) were analyzed by means of DESI imaging mass spectrometry (IMS) with spatial resolution of 100 μm using a computer-controlled DESI imaging stage mounted on a high resolution Orbitrap mass spectrometer. DESI-IMS data were found to predominantly feature complex lipids, including phosphatidyl-inositols, phophatidyl-ethanolamines, phosphatidyl-serines, phosphatidyl-ethanolamine plasmalogens, phosphatidic acids, phosphatidyl-glycerols, ceramides, sphingolipids, and sulfatides among others. Molecular constituents were identified based on their exact mass and MS/MS fragmentation spectra. An identified set of molecules was found to be in good agreement with previously reported DESI imaging data. Different histological tissue types were found to yield characteristic mass spectrometric data in each individual section. Histological features were identified by comparison to hematoxylin-eosin stained neighboring sections. Ions specific to certain histological tissue types (connective tissue, smooth muscle, healthy mucosa, healthy liver parenchyma, and adenocarcinoma) were identified by semi-automated screening of data. While each section featured a number of tissue-specific species, no potential global biomarker was found in the full sample set for any of the tissue types. As an alternative approach, data were analyzed by principal component analysis (PCA) and linear discriminant analysis (LDA) which resulted in efficient separation of data points based on their histological types. A pixel-by-pixel tissue identification method was developed, featuring the PCA/LDA analysis of authentic data set, and localization of unknowns in the resulting 60D, histologically assigned LDA space. Novel approach was found to yield results which are

  7. Automated ambient desorption-ionization platform for surface imaging integrated with a commercial Fourier transform ion cyclotron resonance mass spectrometer.

    PubMed

    Pól, Jaroslav; Vidová, Veronika; Kruppa, Gary; Kobliha, Václav; Novák, Petr; Lemr, Karel; Kotiaho, Tapio; Kostiainen, Risto; Havlícek, Vladimír; Volný, Michael

    2009-10-15

    A fully automated atmospheric pressure ionization platform has been built and coupled with a commercial high-resolution Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) instrument. The outstanding performance of this instrument allowed screening on the basis of exact masses in imaging mode. The main novel aspect was in the integration of the atmospheric pressure ionization imaging into the current software for matrix-assisted laser desorption ionization (MALDI) imaging, which allows the user of this commercial dual-source mass spectrometer to perform MALDI-MS and different ambient MS imaging from the same user interface and to utilize the same software tools. Desorption electrospray ionization (DESI) and desorption atmospheric pressure photoionization (DAPPI) were chosen to test the ambient surface imaging capabilities of this new ionization platform. Results of DESI imaging experiments performed on brain tissue sections are in agreement with previous MS imaging reports obtained by DESI imaging, but due to the high resolution and mass accuracy of the FTICR instrument it was possible to resolve several ions at the same nominal mass in the DESI-MS spectra of brain tissue. These isobaric interferences at low resolution are due to the overlap of ions from different lipid classes with different biological relevance. It was demonstrated that with the use of high-resolution MS fast imaging screening of lipids can be achieved without any preseparation steps. DAPPI, which is a relatively new and less developed ambient ionization technique compared to DESI, was used in imaging mode for the first time ever. It showed promise in imaging of phytocompounds from plant leaves, and selective ionization of a sterol lipid was achieved by DAPPI from a brain tissue sample. PMID:19761221

  8. The Potential Use of Fermented Chickpea and Faba Bean Flour as Food Ingredients.

    PubMed

    Chandra-Hioe, Maria V; Wong, Christina H M; Arcot, Jayashree

    2016-03-01

    Apart from being a rich and inexpensive protein source, legumes provide essential vitamins, minerals and dietary fibre. Considering the nutritional benefits, legumes flour can potentially be incorporated in the development of new products. The aim of this study was to investigate whether fermentation affects the protein content, in vitro protein digestibility, trypsin inhibitor activity and the functionality of proteins in faba bean, desi and kabuli chickpea. Australian grown chickpea and faba bean were selected and initially soaked, de-hulled, dried and milled into flour. This was fermented with lyophilised yoghurt cultures in a 30 °C orbital shaker for 16 h. While protein contents in fermented desi and kabuli flour were lower than their raw counterparts (p > 0.05), it was significantly higher in fermented faba bean. A significant increase (9.5%) in in vitro protein digestibility was found in fermented desi. Trypsin inhibitor activity in fermented desi, kabuli and faba bean reduced by 2.7, 1.1 and 4.7%, respectively (p > 0.05). Overall, the in vitro protein digestibility in flour samples increased, while simultaneously reducing the trypsin inhibitor activity. The water absorption capacity of the fermented kabuli flour significantly increased by 11.3%. All fermented flour samples had significantly higher oil absorption capacity than their corresponding raw flour that was likely due to increased insoluble hydrophobic protein. Although, the foaming capacity in all fermented flour samples was significantly lower than their respective raw samples, only fermented desi and faba bean flour showed lower foaming stability (p > 0.05). The present study suggests that fermented legume flour could fulfill the demand for innovative products of higher nutritional value. PMID:26880215

  9. Chemical Analysis of Complex Organic Mixtures Using Reactive Nanospray Desorption Electrospray Ionization Mass Spectrometry

    SciTech Connect

    Laskin, Julia; Eckert, Peter A.; Roach, Patrick J.; Heath, Brandi S.; Nizkorodov, Sergey A.; Laskin, Alexander

    2012-08-21

    Reactive nanospray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry was utilized for the analysis of secondary organic aerosol produced through ozonolysis of limonene (LSOA). Previous studies showed that LSOA constituents are multifunctional compounds containing aldehyde and ketone groups. In this study, we used the selectivity of the Girard T (GT) reagent towards carbonyl compounds to examine the utility of reactive nano-DESI for the analysis of complex organic mixtures. In these experiments, 1-100 {micro}M GT solution was used as a working solvent for reactive nano-DESI analysis. Abundant products of a single addition of GT to LSOA constituents were observed at GT concentrations in excess of 10 {micro}M. We found that LSOA compounds with 18-20 carbon atoms (dimers) and 27-30 carbon atoms (trimers) react with GT through a simple addition reaction resulting in formation of the carbinolamine derivative. In contrast, reactions of GT with monomeric species result in formation of both the carbinolamine and the hydrazone derivatives. In addition, several monomers did not react with GT on the timescale of our experiment. These molecules were characterized by relatively high values of the double bond equivalent (DBE) and low oxygen content. Furthermore, because addition of a charged GT tag to a neutral molecule eliminates the discrimination against the low proton affinity compounds in the ionization process, reactive nano-DESI analysis enables quantification of individual compounds in the complex mixture. For example, we were able to estimate for the first time the amounts of dimers and trimers in the LSOA mixture. Specifically, we found that the most abundant LSOA dimer was detected at ca. 0.5 pg level and the total amount of dimers and trimers in the analyzed sample was just around 11 pg. Our results indicate that reactive nano-DESI is a valuable approach for examining the presence of specific functional groups and

  10. Characterization of Ce SUP 3+-tributyl phosphate coordination complexes produced by fused droplet electrospray ionization with a target capillary

    SciTech Connect

    Gary S. Groenewold; Jean-Jacques Gaumet

    2011-12-01

    Coordination complexes containing Ce(III) and tri-n-butyl phosphate (TBP) in the 1+, 2+ and 3+ charge states were generated using desorption electrospray ionization (DESI) mass spectrometry, in which the analyte solutions were supplied via a target capillary orthogonally situated with respect to the electrospray. Comparison with direct electrospray (ESI) showed that the same coordination complexes were produced in each experiment, and could be described by the general formula [Ce(NO3)m=0-2(TBP)n](3-m)+. This result indicates that DESI has utility for measuring metal speciation for metal ligand solutions where the gas-phase complexes generated by ESI have been correlated with solution speciation. Such an application would be useful for analyses where it is desirable to limit the total amount of metal being handled, or that have solvent systems that are not readily amenable to ESI. Both the direct ESI and DESI mass spectra showed similar trends with respect to the TBP:Ce ratio, viz. high values tend to favor formation of a larger fraction of the 1+ species, and the 2+ and 3+ species become relatively more important as the ratio is decreased. Within individual charge state ion envelopes, lower TBP:Ce ratios produce coordination complexes with fewer ligands, a trend also seen using both approaches. These trends again point toward strong similarity between the direct ESI and DESI analyses of the metal-ligand solutions. The DESI experiments were less sensitive for measuring the coordination complexes compared to the direct ESI experiments, by a factor of 10 - 100 depending on whether minimum detectable concentration or absolute ion abundances were considered. Nevertheless, mid-picomolar quantities of coordination complexes were measured using the target capillary, indicating that sensitivity would be sufficient for measuring species in many industrial separations processes.

  11. The quantitative surface analysis of an antioxidant additive in a lubricant oil matrix by desorption electrospray ionization mass spectrometry

    PubMed Central

    Da Costa, Caitlyn; Reynolds, James C; Whitmarsh, Samuel; Lynch, Tom; Creaser, Colin S

    2013-01-01

    RATIONALE Chemical additives are incorporated into commercial lubricant oils to modify the physical and chemical properties of the lubricant. The quantitative analysis of additives in oil-based lubricants deposited on a surface without extraction of the sample from the surface presents a challenge. The potential of desorption electrospray ionization mass spectrometry (DESI-MS) for the quantitative surface analysis of an oil additive in a complex oil lubricant matrix without sample extraction has been evaluated. METHODS The quantitative surface analysis of the antioxidant additive octyl (4-hydroxy-3,5-di-tert-butylphenyl)propionate in an oil lubricant matrix was carried out by DESI-MS in the presence of 2-(pentyloxy)ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate as an internal standard. A quadrupole/time-of-flight mass spectrometer fitted with an in-house modified ion source enabling non-proximal DESI-MS was used for the analyses. RESULTS An eight-point calibration curve ranging from 1 to 80 µg/spot of octyl (4-hydroxy-3,5-di-tert-butylphenyl)propionate in an oil lubricant matrix and in the presence of the internal standard was used to determine the quantitative response of the DESI-MS method. The sensitivity and repeatability of the technique were assessed by conducting replicate analyses at each concentration. The limit of detection was determined to be 11 ng/mm2 additive on spot with relative standard deviations in the range 3–14%. CONCLUSIONS The application of DESI-MS to the direct, quantitative surface analysis of a commercial lubricant additive in a native oil lubricant matrix is demonstrated. © 2013 The Authors. Rapid Communications in Mass Spectrometry published by John Wiley & Sons, Ltd. PMID:24097398

  12. Developing repeatable measurements for reliable analysis of molecules at surfaces using desorption electrospray ionization.

    PubMed

    Green, F M; Stokes, P; Hopley, C; Seah, M P; Gilmore, I S; O'Connor, G

    2009-03-15

    Desorption electrospray ionization (DESI) is a powerful ambient ionization technique that can provide high-sensitivity mass spectrometry information directly from surfaces at ambient pressure. Although a growing amount of research has been devoted to exploring different applications, there are few studies investigating the basic parameters and underpinning metrology. An understanding of these is crucial to develop DESI as the robust and reliable technique required for significant uptake by industry. In this work, we begin with a systematic study of the parameters affecting the repeatability, sensitivity, and rate of consumption of material with DESI. To do this we have developed a model sample consisting of a thin uniform film of controlled thickness of Rhodamine B on glass. This model sample allowed assessment of optimal sensitivity and spot shape under different conditions. In addition, it allowed us to study the surface in more detail to understand why and how each parameter affects these. Using the model sample to optimize the instrument parameters for DESI led to an absolute intensity repeatability of better than 15%, achieved over a period of 1 day. This model sample provides valuable insight into the electrospray-sample interaction and the desorption mechanism. Confocal microscopy of areas analyzed by DESI allow droplet distribution, material utilization, and spot size to be determined. Studying surface erosion also gives the erosion rate of material, analogous to the sputtering yield in secondary ion mass spectrometry. The results of the study provide a clear description that explains the differences observed with changing electrospray parameters allowing optimization of the technique, for both spatial resolution and sensitivity. PMID:19281262

  13. Chemical analysis of complex organic mixtures using reactive nanospray desorption electrospray ionization mass spectrometry.

    PubMed

    Laskin, Julia; Eckert, Peter A; Roach, Patrick J; Heath, Brandi S; Nizkorodov, Sergey A; Laskin, Alexander

    2012-08-21

    Reactive nanospray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry was utilized for the analysis of secondary organic aerosol produced through ozonolysis of limonene (LSOA). Previous studies have shown that LSOA constituents are multifunctional compounds containing at least one aldehyde or ketone groups. In this study, we used the selectivity of the Girard's reagent T (GT) toward carbonyl compounds to examine the utility of reactive nano-DESI for the analysis of complex organic mixtures. In these experiments, 1-100 μM GT solutions were used as the working solvents for reactive nano-DESI analysis. Abundant products from the single addition of GT to LSOA constituents were observed at GT concentrations in excess of 10 μM. We found that LSOA dimeric and trimeric compounds react with GT through a simple addition reaction resulting in formation of the carbinolamine derivative. In contrast, reactions of GT with monomeric species result in the formation of both the carbinolamine and the hydrazone derivatives. In addition, several monomers did not react with GT on the time scale of our experiment. These molecules were characterized by relatively high values of the double bond equivalent and low oxygen content. Furthermore, because addition of a charged GT tag to a neutral molecule eliminates the discrimination against the low proton affinity compounds in the ionization process, reactive nano-DESI analysis enables quantification of individual compounds in the complex mixture. For example, we were able to estimate for the first time the amounts of dimers and trimers in the LSOA mixture. Specifically, we found that the most abundant LSOA dimer was detected at the ~0.5 pg level and the total amount of dimers and trimers in the analyzed sample was ~11 pg. Our results indicate that reactive nano-DESI is a valuable approach for examining the presence of specific functional groups and for the quantification of compounds possessing

  14. Desorption electrospray ionization mass spectrometry analysis of lipids after two-dimensional high-performance thin-layer chromatography partial separation

    PubMed Central

    Paglia, Giuseppe; Ifa, Demian R.; Wu, Chunping; Corso, Gaetano; Cooks, R. Graham

    2010-01-01

    Molecular imaging of separate but still incompletely resolved spots on high-performance thin-layer chromatography (HPTLC) plates is used for the direct analysis of porcine brain lipids by desorption electrospray ionization mass spectrometry (DESI-MS). Seven class-specific spots were imaged in the negative ion mode and shown to contain more than fifty lipids. A low lateral resolution of 400 × 400 μm allowed simple, rapid and incomplete separation to be combined with DESI imaging for the identification of many components of these extremely complex mixtures. In this work, tandem mass spectrometry (MS/MS) was also employed to confirm the identity of particular lipids directly on HPTLC plates. PMID:20128616

  15. Effects of gamma irradiation on the shoot length of Cicer seeds [rapid communication

    NASA Astrophysics Data System (ADS)

    Toker, Cengiz; Uzun, Bulent; Canci, Huseyin; Oncu Ceylan, F.

    2005-08-01

    The effects of radiation on the shoot and root lengths of germinated seedling of irradiated seeds of Cicer species, i.e. three kabuli types and four desi types of cultivated chickpea ( Cicer arietinum Ladiz.) and 2 annual wild types ( C. reticulatum Ladiz. and C. bijugum K.H. Rech.) were investigated. The seeds were irradiated with a 60Co gamma source using 0, 200, 300 and 400 Gy doses at 1.66 kGy h -1. At 200 Gy minor effects could be observed, but at 400 Gy an obvious depression of shoot length was observed. The kabuli types were more affected than the desi ones. The critical dose that prevented the shoot and root elongation varied among species and also ranged from genotypes to genotype within species.

  16. Exploring dark matter microphysics with galaxy surveys

    NASA Astrophysics Data System (ADS)

    Escudero, Miguel; Mena, Olga; Vincent, Aaron C.; Wilkinson, Ryan J.; Bœhm, Céline

    2015-09-01

    We use present cosmological observations and forecasts of future experiments to illustrate the power of large-scale structure (LSS) surveys in probing dark matter (DM) microphysics and unveiling potential deviations from the standard ΛCDM scenario. To quantify this statement, we focus on an extension of ΛCDM with DM-neutrino scattering, which leaves a distinctive imprint on the angular and matter power spectra. After finding that future CMB experiments (such as COrE+) will not significantly improve the constraints set by the Planck satellite, we show that the next generation of galaxy clustering surveys (such as DESI) could play a leading role in constraining alternative cosmologies and even have the potential to make a discovery. Typically we find that DESI would be an order of magnitude more sensitive to DM interactions than Planck, thus probing effects that until now have only been accessible via N-body simulations.

  17. 3.9 GHz superconducting accelerating 9-cell cavity vertical test results

    SciTech Connect

    Khabiboulline, Timergali; Cooper, Charles; Dhanaraj, Nandhini; Edwards, Helen; Foley, Mike; Harms, Elvin; Mitchell, Donald; Rowe, Allan; Solyak, Nikolay; Moeller, Wolf-Dietrich; /DESY

    2007-06-01

    The 3rd harmonic 3.9GHz accelerating cavity was proposed to improve the beam performance of the FLASH (TTF/DESY) facility [1]. In the frame of a collaborative agreement, Fermilab will provide DESY with a cryomodule containing a string of four cavities. In addition, a second cryomodule with one cavity will be fabricated for installation in the Fermilab photo-injector, which will be upgraded for the ILC accelerator test facility. The first 9-cell Nb cavities were tested in a vertical setup and they didn't reach the designed accelerating gradient [2]. The main problem was a multipactor in the HOM couplers, which lead to overheating and quenching of the HOM couplers. New HOM couplers with improved design are integrated in the next 9-cell cavities. In this paper we present all results of the vertical tests.

  18. A 1.8 K test facility for superconducting RF cavities

    SciTech Connect

    Horlitz, G.; Knopf, U.; Lange, R.; Petersen, B.; Sellmann, D.; Trines, D.; Peterson, T.

    1994-04-01

    To demonstrate the feasibility of superconducting RF technology for a high energy e{sup +}/e{sup {minus}} collider, a research and development program has begun with collaborators from Europe, Asia, and North America. The immediate goal of the R&D program is to build and operate a 50 meter-long linac at DESY with 1.3 GHz superconducting RF cavities at a temperature of 1.8 K - 2.0 K and an accelerating gradient of 15 MV/meter. The refrigeration for the test system at DESY initially will have a capacity of about 100 W at 1.8 K, distributed among three test cryostats. In a second step, refrigeration will be upgraded to 200 W at 1.8 K in order to supply the 50 meter test linac. This paper describes the cryogenics of this test system.

  19. FPGA-based Klystron linearization implementations in scope of ILC

    DOE PAGESBeta

    Omet, M.; Michizono, S.; Matsumoto, T.; Miura, T.; Qiu, F.; Chase, B.; Varghese, P.; Schlarb, H.; Branlard, J.; Cichalewski, W.

    2015-01-23

    We report the development and implementation of four FPGA-based predistortion-type klystron linearization algorithms. Klystron linearization is essential for the realization of ILC, since it is required to operate the klystrons 7% in power below their saturation. The work presented was performed in international collaborations at the Fermi National Accelerator Laboratory (FNAL), USA and the Deutsches Elektronen Synchrotron (DESY), Germany. With the newly developed algorithms, the generation of correction factors on the FPGA was improved compared to past algorithms, avoiding quantization and decreasing memory requirements. At FNAL, three algorithms were tested at the Advanced Superconducting Test Accelerator (ASTA), demonstrating a successfulmore » implementation for one algorithm and a proof of principle for two algorithms. Furthermore, the functionality of the algorithm implemented at DESY was demonstrated successfully in a simulation.« less

  20. FPGA-based Klystron linearization implementations in scope of ILC

    SciTech Connect

    Omet, M.; Michizono, S.; Varghese, P.; Schlarb, H.; Branlard, J.; Cichalewski, W.

    2015-01-23

    We report the development and implementation of four FPGA-based predistortion-type klystron linearization algorithms. Klystron linearization is essential for the realization of ILC, since it is required to operate the klystrons 7% in power below their saturation. The work presented was performed in international collaborations at the Fermi National Accelerator Laboratory (FNAL), USA and the Deutsches Elektronen Synchrotron (DESY), Germany. With the newly developed algorithms, the generation of correction factors on the FPGA was improved compared to past algorithms, avoiding quantization and decreasing memory requirements. At FNAL, three algorithms were tested at the Advanced Superconducting Test Accelerator (ASTA), demonstrating a successful implementation for one algorithm and a proof of principle for two algorithms. Furthermore, the functionality of the algorithm implemented at DESY was demonstrated successfully in a simulation.

  1. Higher Order Modes in Third Harmonic Cavities for XFEL/FLASH

    SciTech Connect

    Shinton, I.R.R.; Baboi, N.; Eddy, N.; Flisgen, T.; Glock, H.W.; Jones, R.M.; Juntong, N.; Khabiboulline, T.N.; van Rienen, U; Zhang, P.; /Manchester U. /DESY /Cockcroft Inst. Accel. Sci. Tech.

    2010-06-01

    We analyse higher order modes in the 3.9 GHz bunch shaping cavities recently installed in the FLASH facility at DESY. We report on recent experimental results on the frequency spectrum from probe based measurements made at CMTB at DESY. These are compared to those predicted by finite difference and finite element computer codes. This study is focused mainly on the dipole component of the multi-pole expansion of the wakefield. The modes are readily identifiable as single-cavity modes provided the frequencies of these modes are below the cut-off of the inter-connecting beam pipes. The modes above cut-off are coupled to the 4 cavities and are distinct from single cavity modes.

  2. Eddy current scanning at Fermilab

    SciTech Connect

    Boffo, C.; Bauer, P.; Foley, M.; Brinkmann, A.; Ozelis, J.; /Jefferson Lab

    2005-07-01

    In the framework of SRF cavity development, Fermilab is creating the infrastructure needed for the characterization of the material used in the cavity fabrication. An important step in the characterization of ''as received'' niobium sheets is the eddy current scanning. Eddy current scanning is a non-destructive technique first adopted and further developed by DESY with the purpose of checking the cavity material for sub-surface defects and inclusions. Fermilab has received and further upgraded a commercial eddy current scanner previously used for the SNS project. The upgrading process included developing new filtering software. This scanner is now used daily to scan the niobium sheets for the Fermilab third harmonic and transverse deflecting cavities. This paper gives a status report on the scanning results obtained so far, including a discussion of the typology of signals being detected. We also report on the efforts to calibrate this scanner, a work conducted in collaboration with DESY.

  3. Development and quality evaluation of aonla mouth freshner.

    PubMed

    Barwal, Vishal Singh; Garg, Vivek; Sharma, Rakesh

    2010-12-01

    Nutritive and palatable mouth freshners were prepared from dehydrated aonla (Emblica officinalis Gaertn) pulp of 'Desi' and 'Banarsi' cultivars by mixing carboxy methyl cellulose, gums, arecanut, cardamom, sugar and milk powder at different proportions as a substitute for pan masala, tobacco and gutka. Mouth fresheners developed were packed in high density polyethylene pouches (HDPE, 100 gauge), stored at ambient conditions (8-20 °C, 60%RH) and analysed for physico-chemical and sensory quality attributes at different storage intervals. During storage for 6 months, ascorbic acid and overall acceptability of mouth freshener decreased (p ≤ 0.05) and moisture content increased. The equivalent relative humidity of mouth freshener was 49% and 53% in 'Desi' and 'Banarsi' cultivars, respectively. Despite the changes observed in various physico- chemical and sensory attributes, the overall sensory quality attributes of mouth freshners remained acceptable. PMID:23572710

  4. An innovative method based on quick, easy, cheap, effective, rugged, and safe extraction coupled to desorption electrospray ionization-high resolution mass spectrometry for screening the presence of paralytic shellfish toxins in clams.

    PubMed

    Mattarozzi, Monica; Bianchi, Federica; Milioli, Marco; Cavazza, Antonella; Careri, Maria

    2016-01-15

    The capabilities of desorption electrospray ionization-high resolution mass spectrometry (DESI-HRMS) were tested for screening the presence of some paralytic shellfish toxins in clams. A quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach is proposed for sample clean-up. QuEChERS extraction was optimized by using a full factorial design followed by the multicriteria method of the desirability functions. Quantitation limits in the microgram per kilogram range proved reliability of the method for the detection of the investigated toxins in accordance to the rules laid down by European legislation. The optimized QuEChERS-DESI-HRMS based-method allowed for a rapid reliable screening of the investigated compounds at levels of interest, thus being useful for high-throughput analyses. PMID:26592627

  5. QUENCH STUDIES AND PREHEATING ANALYSIS OF SEAMLESS

    SciTech Connect

    Palczewski, Ari; Geng, Rongli; Eremeev, Grigory

    2013-09-01

    One of the alternative manufacturing technologies for SRF cavities is hydroforming from seamless tubes. Although this technology has produced cavities with gradient and Q-values comparable to standard EBW/EP cavities, a few questions remain. One of these questions is whether the quench mechanism in hydroformed cavities is the same as in standard electron beam welded cavities. Towards this effort Jefferson Lab performed quench studies on 2 9 cell seamless hydroformed cavities. These cavities include DESY's - Z163 and Z164 nine-cell cavities hydroformed at DESY. Initial Rf test results Z163 were published in SRF2011. In this report we will present post JLAB surface re-treatment quench studies for each cavity. The data will include OST and T-mapping quench localization as well as quench location preheating analysis comparing them to the observations in standard electron beam welded cavities.

  6. Mechanical stability study of type IV cryomodule (ILC prototype)

    SciTech Connect

    McGee, M.W.; Doremus, R.; Wands, C.R.; /Fermilab

    2007-06-01

    An ANSYS modal and harmonic finite element analysis (FEA) was performed in order to investigate cryomodule design mechanical stability for the proposed International Linear Collider (ILC). The current cryomodule, designated Type IV or (T4CM), closely follows the Type III TESLA Test Facility (TTF) version used at DESY, with the exception of a proposed location of the superconducting (SC) quadrupole at the center. This analysis considered the stringent stability criteria established for the ILC, where vertical motion for the SC quadrupole is limited to the micron range at a few Hz. Model validation was achieved through Type III cryomodule vibration measurement studies performed at DESY. The effect of support location, support stiffness and other important parameters were considered in a parametric sensitivity study. FEA results, fast motion investigations and stabilization techniques are discussed.

  7. What Is the Opposite of Pandora's Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources.

    PubMed

    B Cody, Robert

    2013-01-01

    The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as "ambient ionization" sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of "direct ionization," meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S. PMID:24349926

  8. Associated production of heavy quarkonia and electroweak bosons at present and future colliders

    NASA Astrophysics Data System (ADS)

    Kniehl, Bernd A.; Palisoc, Caesar P.; Zwirner, Lennart

    2002-12-01

    We investigate the associated production of heavy quarkonia, with angular-momentum quantum numbers 2S+1LJ=1S0,3S1,1P1,3PJ (J=0,1,2), and photons, Z bosons, and W bosons in photon-photon, photon-hadron, and hadron-hadron collisions within the factorization formalism of nonrelativistic quantum chromodynamics providing all contributing partonic cross sections in analytic form. In the case of photoproduction, we also include the resolved-photon contributions. We present numerical results for the processes involving J/ψ and χcJ mesons appropriate for the Fermilab Tevatron, CERN LHC, DESY TESLA, operated in the e+e- and γγ modes, and DESY THERA.

  9. Räumliches Hören

    NASA Astrophysics Data System (ADS)

    Blauert, Jens; Braasch, Jonas

    Unsere Hörereignisse (Hörobjekte, Laute) existieren jeweils zu ihrer Zeit an ihrem Ort und sind mit jeweils spezifischen Eigenschaften ausgerüstet. "Räumliches Hören“ als wissenschaftliches Fachgebiet erforscht und beschreibt die Beziehungen zwischen den Orten sowie den räumlichen Ausdehnungen der Hörereignisse untereinander und zu den korrelierten Merkmalen anderer Ereignisse - vorwiegend Schallereignisse, aber z. B. auch physiologische Vorgänge, Ereignisse anderer Sinnesgebiete usw. (s. hierzu Blauert 1974 etc., woraus einige der folgenden Bilder entnommen sind). Übersichtsdarstellungen findet man z. B. auch bei (Bloch 1893, Pierce 1901, von Hornbostel 1926, Trimble 1928, Kietz 1953, Woodworth u. Schlosberg 1954, von Békésy 1960, Aschoff 1963, Keidel 1966, Erulkar 1972, Durlach u. Colburn 1978, Gatehouse 1979, Blauert 1983, Yost u. Gourevitch 1987, Wightman u. Kistler 1993, Begault 1994, Gilkey u. Anderson 1996).

  10. [A failed experiment - Carl Friedrich von Weizsäcker, Jürgen Habermas and the Max-Planck Society].

    PubMed

    Leendertz, Ariane

    2014-01-01

    From 1970 to 1980 Carl Friedrich von Weizsäcker headed the Max-Planck-lnstitut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPI for the study of the living conditions of the world of science and technology) in Starnberg, jointly with Jürgen Habermas since 1971. From the start, the Max Planck Society regarded the new institute as an experiment that might perhaps be aborted a few years later. This is exactly what happened. With the retirement of Weizsäcker, his section was closed and the whole institute was renamed. In 1981. Habermas resigned, and then the institute was closed. This paper focusses on some of the problem constellations within the institute that partly explain its development and eventual closure: its birth out of the idea of scientific policy advice, the debates within the Max Planck Society and the complex relationship between Weizsäcker and Jürgen Habermas. PMID:24974605

  11. Zwischen Commonsense und Wissenschaft Mathematik in der Erziehungsphilosophie A. N. Whiteheads

    NASA Astrophysics Data System (ADS)

    Sölch, Dennis

    Obwohl Whitehead heute wie selbstverständlich als Philosoph rezipiert wird, so hat er seine wissenschaftliche Laufbahn doch als Mathematiker begonnen. Lange Zeit war er gemeinsam mit Bertrand Russell als Autor der Principia Mathematica unter Mathematikern und mathematischen Logikern deutlich besser bekannt als unter Philosophen. Doch selbst von denjenigen, die sich mit Whiteheads Überlegungen zur Metaphysik, zur Wissenschaftsgeschichte und zur Theologie befassen, werden seine Schriften zur Philosophie von Erziehung und Bildung häufig kaum beachtet. So entgeht es leicht, dass Whitehead nicht nur ein auf theoretischem Gebiet brillanter Mathematiker war, sondern sein theoretisches Fachwissen im Hinblick auf pädagogische und didaktische Relevanz fortwährend reflektiert hat.

  12. VDI-Richtlinien - mit Technischen Regeln Wirtschaftlichkeit erhöhen und Standards setzen

    NASA Astrophysics Data System (ADS)

    Mandelartz, Johannes

    Der Verein Deutscher Ingenieure e.V. (VDI) ist ein gemeinnütziger, wirtschaftlich und politisch unabhängiger, technisch-wissenschaftlicher Verein von Ingenieuren und Naturwissenschaftlern. Mit über 137 000 persönlich zugeordneten Mitgliedern ist er eine der größten Ingenieur-Vereinigungen Europas und gilt in Deutschland als führender Sprecher der Technik und der Ingenieure. 1856 gegründet, hat er viele für die Technik wesentliche Entwicklungen in Gang gesetzt, so im Bereich der technischen Überwachung, der technischen Regelsetzung und Normung, der Arbeitsstudien, im gewerblichen Rechtsschutz und im Patentwesen. Seit seiner Gründung sieht es der VDI als seine Aufgabe, "das Zusammenwirken aller geistiger Kräfte der Technik im Bewusstsein ethischer Verantwortung zu fördern“ und die Lebensmöglichkeiten aller Menschen durch Entwicklung und sinnvoller Anwendung technischer Mittel zu verbessern.

  13. elecTUM: Umsetzung der eLearning-Strategie der Technischen Universität München

    NASA Astrophysics Data System (ADS)

    Rathmayer, Sabine; Gergintchev, Ivan

    An der TUM wurde ein umfassendes und integriertes eLearning-Konzept umgesetzt, welches Präsenzstudium und eLearning in allen Leistungsbereichen der Universität miteinander verzahnt. Ein besonderer Schwerpunkt lag dabei in der Schaffung einer effizienten und wettbewerbsfähigen integrierten eLearning Infrastruktur in Hinblick auf die noch weiter steigenden Studienanfängerzahlen ab dem Jahr 2011 sowie die Umsetzung von eBologna. Die Etablierung einer hochschulweiten Lernplattform stellte eine wesentliche Basis für die Umsetzung der eLearning-Strategie dar. Die wissenschaftliche und wirtschaftliche Anschlussfähigkeit im Hinblick auf eine Verwertung der Projektergebnisse wurde durch die aktive Beteiligung an einer Vielzahl hochschulübergreifender Arbeitskreise, Fachtagungen und Kooperationen, vor allem über Organisations- und Dienstleistungsmodelle sowie innovative technische Entwicklungen, sichergestellt.

  14. Dynamisierung und Erstarrung in der modernen Gesellschaft - Das Beschleunigungsphänomen

    NASA Astrophysics Data System (ADS)

    Rosa, Hartmut

    Dass die Geschichte der Moderne die Geschichte einer ungeheuren Beschleunigung "des Lebens“, "der Kultur“, "der Geschichte“ oder gar "der Zeit selbst“ sei, ist eine Behauptung, der man in Büchern über die Moderne - gelehrten wie ungelehrten - so häufig begegnet, dass sie geradezu als eine Binsenweisheit gelten kann. Völlig unklar bleibt dabei jedoch in aller Regel, was sich dabei wirklich beschleunigt hat und welcher Begriff von Beschleunigung dieser Auffassung zugrunde liegt. Ich will im Folgenden zunächst einen wissenschaftlich vertretbaren Begriff von Beschleunigung entwickeln, um danach mit Hilfe dieses Instruments zu überprüfen, inwieweit die Geschichte der Moderne wirklich als eine Beschleunigungsgeschichte aufgefasst werden kann.

  15. NUCLEAR PHYSICS: The First Nine-Cell TESLA Cavity Made in China

    NASA Astrophysics Data System (ADS)

    Lu, Xiang-Yang; Quan, Sheng-Wen; Zhang, Bao-Cheng; Hao, Jian-Kui; Zhu, Feng; Lin, Lin; Xu, Wen-Can; Wang, Er-Dong; Wang, Fang; Jin, Song; Xin, Tian-Mu; Yao, Zhong-Yuan; Chen, Jia-Er; Zhao, Kui

    2008-11-01

    A totally home-made 9-cell TESLA type superconducting cavity is made at Peking University. The cavity fabrication is according to DESY specification. The cavity is made of high purity niobium from OTIC, Ningxia. The electron beam welding is carried out at Harbin Institute of Technology, Harbin. By the cooperation, the cavity is tested at Thomas Jefferson National Accelerator Facility, USA. The preliminary result shows the acceleration gradient Eacc is 23MV/m without quench and has potential for improvement.

  16. Radiative effects in scattering of polarized leptons by polarized nucleons and light nuclei

    SciTech Connect

    Igor Akushevich; A. Ilyichev; N. Shumeiko

    2001-07-01

    Recent developments in the field of radiative effects in polarized lepton-nuclear scattering are reviewed. The processes of inclusive, semi-inclusive, diffractive and elastic scattering are considered. The explicit formulae obtained within the covariant approach are discussed. FORTRAN codes POLRAD, RADGEN, HAPRAD, DIFFRAD and MASCARAD created on the basis of the formulae are briefly described. Applications for data analysis of the current experiments on lepton-nuclear scattering at CERN, DESY, SLAC and TJNAF are illustrated by numerical results.

  17. Distinctive Glycerophospholipid Profiles of Human Seminoma and Adjacent Normal Tissues by Desorption Electrospray Ionization Imaging Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Masterson, Timothy A.; Dill, Allison L.; Eberlin, Livia S.; Mattarozzi, Monica; Cheng, Liang; Beck, Stephen D. W.; Bianchi, Federica; Cooks, R. Graham

    2011-08-01

    Desorption electrospray ionization mass spectrometry (DESI-MS) has been successfully used to discriminate between normal and cancerous human tissue from different anatomical sites. On the basis of this, DESI-MS imaging was used to characterize human seminoma and adjacent normal tissue. Seminoma and adjacent normal paired human tissue sections (40 tissues) from 15 patients undergoing radical orchiectomy were flash frozen in liquid nitrogen and sectioned to 15 μm thickness and thaw mounted to glass slides. The entire sample was two-dimensionally analyzed by the charged solvent spray to form a molecular image of the biological tissue. DESI-MS images were compared with formalin-fixed, hematoxylin and eosin (H&E) stained slides of the same material. Increased signal intensity was detected for two seminolipids [seminolipid (16:0/16:0) and seminolipid (30:0)] in the normal tubule testis tissue; these compounds were undetectable in seminoma tissue, as well as from the surrounding fat, muscle, and blood vessels. A glycerophosphoinositol [PI(18:0/20:4)] was also found at increased intensity in the normal testes tubule tissue when compared with seminoma tissue. Ascorbic acid (i.e., vitamin C) was found at increased amounts in seminoma tissue when compared with normal tissue. DESI-MS analysis was successfully used to visualize the location of several types of molecules across human seminoma and normal tissues. Discrimination between seminoma and adjacent normal testes tubules was achieved on the basis of the spatial distributions and varying intensities of particular lipid species as well as ascorbic acid. The increased presence of ascorbic acid within seminoma compared with normal seminiferous tubules was previously unknown.

  18. Capture cavity II results at FNAL

    SciTech Connect

    Branlard, Julien; Chase, Brian; Cancelo, G.; Carcagno, R.; Edwards, H.; Fliller, R.; Hanna, B.; Harms, Elvan; Hocker, A.; Koeth, T.; Kucera, M.; /Fermilab

    2007-06-01

    As part of the research and development towards the International Linear Collider (ILC), several test facilities have been developed at Fermilab. This paper presents the latest Low Level RF (LLRF) results obtained with Capture Cavity II (CCII) at the ILC Test Accelerator (ILCTA) test facility. The main focus will be on controls and RF operations using the SIMCON based LLRF system developed in DESY [1]. Details about hardware upgrades and future work will be discussed.

  19. Spin Physics at HERMES

    SciTech Connect

    Contalbrigo, M.

    2007-11-19

    The HERMES experiment at DESY is a second generation experiment to study the spin structure of the nucleon by measuring not only inclusive but also semi-inclusive and exclusive processes in deep-inelastic lepton scattering where both beam and target can be polarised. An overview of finalized measurements and an outlook to upcoming new results is given for data taken with hydrogen and deuterium targets with longitudinal and transverse nucleon polarisation.

  20. U.C. Davis high energy particle physics research: Technical progress report -- 1990

    SciTech Connect

    1990-12-31

    Summaries of progress made for this period is given for each of the following areas: (1) Task A--Experiment, H1 detector at DESY; (2) Task C--Experiment, AMY detector at KEK; (3) Task D--Experiment, fixed target detectors at Fermilab; (4) Task F--Experiment, PEP detector at SLAC and pixel detector; (5) Task B--Theory, particle physics; and (6) Task E--Theory, particle physics.

  1. Longitudinal Bunch Shape Diagnostics With Coherent Radiation And a Transverse Deflecting Cavity at TTF2

    SciTech Connect

    Grimm, O.; Frohlich, L.; Klose, K.; Nagl, M.; Peters, O.; Rossbach, J.; Schlarb, H.; Emma, P.J.; McCormick, D.; Ross, M.; Smith, T.J.; /SLAC

    2005-08-04

    At the DESY TTF2 linear accelerator three special techniques to characterize the longitudinal charge distribution of the electron bunches that drive the free-electron laser are currently under study: electro-optical sampling, far-infrared spectral analysis of coherent radiation and the use of a transverse deflecting cavity to streak the bunch. The principles and implementations of the latter two are described in this paper. Details on electro-optical sampling can be found in [1].

  2. Measurement of the spin-structure function g 2 and the semi-inclusive double-spin asymmetries at HERMES

    NASA Astrophysics Data System (ADS)

    Korotkov, V. A.

    2014-01-01

    A measurement of the virtual-photon asymmetry A 2 and of the spin-structure function g 2 of the proton are presented for the kinematic range of the HERMES experiment carried out at the HERA electron storage ring at DESY. Semi-inclusive longitudinal double-spin asymmetries provide new insight into the valence quark helicity distributions Δ u v and Δ d v.

  3. Recent HERMES results on transverse-momentum dependent phenomena from scattering off unpolarised targets

    NASA Astrophysics Data System (ADS)

    Karyan, Gevorg

    2015-01-01

    HERMES experiment at DESY in Hamburg collected a wealth of semi-inclusive deep-inelastic scattering data using the 27.6 GeV lepton beam and pure gaseous, unpolarised hydrogen and deuterium targets. These data can be used in studies of the transverse-momentum dependent effects and can provide a check of existing models for transverse-momentum dependent parton distribution and fragmentation functions.

  4. Experimental Plans to Explore Dielectric Wakefield Acceleration in the THZ Regime

    SciTech Connect

    Lemery, F.; Mihalcea, D.; Piot, P.; Behrens, C.; Elsen, E.; Flottmann, K.; Gerth, C.; Kube, G.; Schmidt, B.; Osterhoff, J.; Stoltz, P.

    2011-09-07

    Dielectric wakefield accelerators have shown great promise toward high-gradient acceleration. We investigate the performances of a possible experiment under consideration at the FLASH facility in DESY to explore wakefield acceleration with an enhanced transformer ratio. The experiment capitalizes on a unique pulse shaping capability recently demonstrated at this facility. In addition, the facility incorporates a superconducting linear accelerator that could generate bunch trains with closely spaced bunches thereby opening the exploration of potential dynamical effects in dielectric wakefield accelerators.

  5. Investigation of some biologically relevant redox reactions using electrochemical mass spectrometry interfaced by desorption electrospray ionization

    PubMed Central

    Lu, Mei; Wolff, Chloe; Cui, Weidong

    2013-01-01

    Recently we have shown that, as a versatile ionization technique, desorption electrospray ionization (DESI) can serve as a useful interface to combine electrochemistry (EC) with mass spectrometry (MS). In this study, the EC/DESI-MS method has been further applied to investigate some aqueous phase redox reactions of biological significance, including the reduction of peptide disulfide bonds and nitroaromatics as well as the oxidation of phenothiazines. It was found that knotted/enclosed disulfide bonds in the peptides apamin and endothelin could be electrochemically cleaved. Subsequent tandem MS analysis of the resulting reduced peptide ions using collision-induced dissociation (CID) and electron-capture dissociation (ECD) gave rise to extensive fragment ions, providing a fast protocol for sequencing peptides with complicated disulfide bond linkages. Flunitrazepam and clonazepam, a class of nitroaromatic drugs, are known to undergo reduction into amines which was proposed to involve nitroso and N-hydroxyl intermediates. Now in this study, these corresponding intermediate ions were successfully intercepted and their structures were confirmed by CID. This provides mass spectrometric evidence for the mechanism of the nitro to amine conversion process during nitroreduction, an important redox reaction involved in carcinogenesis. In addition, the well-known oxidation reaction of chlorpromazine was also examined. The putative transient one-electron transfer product, the chlorpromazine radical cation (m/z 318), was captured by MS, for the first time, and its structure was also verified by CID. In addition to these observations, some features of the DESI-interfaced electrochemical mass spectrometry were discussed, such as simple instrumentation and the lack of background signal. These results further demonstrate the feasibility of EC/DESI-MS for the study of the biology-relevant redox chemistry and would find applications in proteomics and drug development research. PMID

  6. Commissioning and early operating experience with the Fermilab horizontal test facility

    SciTech Connect

    Carcagno, R.; Chase, B.; Harms, E.; Hocker, A.; Prieto, P.; Reid, J.; Rowe, A.; Theilacker, J.; Votava, M.; /Fermilab

    2007-10-01

    Fermilab has constructed a facility for testing dressed superconducting radiofrequency (RF) cavities at 1.8 K with high-power pulsed RF. This test stand was designed to test both 9-cell 1.3 GHz TESLA-style cavities and 9-cell 3.9 GHz cavities being built by Fermilab for DESY's TTF-FLASH facility. An overview of the test stand and a description of its initial commissioning is described here.

  7. Experimental Program Final Technical Progress Report: 15 February 2007 to 30 September 2012

    SciTech Connect

    Kinney, Edward R.

    2014-09-12

    This is the final technical report of the grant DE-FG02-04ER41301 to the University of Colorado at Boulder entitled "Intermediate Energy Nuclear Physics" and describes the results of our funded activities during the period 15 February 2007 to 30 September 2012. These activities were primarily carried out at Fermilab, RHIC, and the German lab DESY. Significant advances in these experiments were carried out by members of the Colorado group and are described in detail.

  8. Optical spectra of FLASH generated plasmas

    NASA Astrophysics Data System (ADS)

    Stránský, M.; Rohlena, Karel

    2014-05-01

    Time integrated measurements of optical spectra of the plasma generated by pulses of the free electron laser facility FLASH on a solid target at DESY Hamburg are interpreted in terms of plasma hydrodynamics. It is shown that the main contribution to the optical range comes from the expanding stage of the plasma evolution on a ns scale, whereas the UV part is partially obscured by the optically dense outstreaming plasma near the ablated hole.

  9. Nuclear Physics Laboratory, University of Colorado, Final Progress Report

    SciTech Connect

    Kinney, E.R., ed.

    2004-05-12

    OAK-B135 The results and progress of research funded by DOE grant number DOE-FG03-95ER40913 at the University of Colorado at Boulder is described. Includes work performed at the HERMES experiment at DESY to study the quark structure of the nucleon and the hadronization process in nuclei, as well as hadronic reactions studied at LAMPF, KEK, and Fermilab.

  10. Search for rare B decays

    NASA Astrophysics Data System (ADS)

    Albrecht, H.; Hamacher, T.; Hofmann, R. P.; Kirchhoff, T.; Mankel, R.; Nau, A.; Nowak, S.; Reßing, D.; Schröder, H.; Schulz, H. D.; Walter, M.; Wurth, R.; Hast, C.; Kapitza, H.; Kolanoski, H.; Kosche, A.; Lange, A.; Lindner, A.; Schieber, M.; Siegmund, T.; Spaan, B.; Thurn, H.; Töpfer, D.; Wegener, D.; Eckstein, P.; Frankl, C.; Graf, J.; Schmidtler, M.; Schramm, M.; Schubert, K. R.; Schwierz, R.; Waldi, R.; Reim, K.; Wegener, H.; Eckmann, R.; Kuipers, H.; Mai, O.; Mundt, R.; Oest, T.; Reiner, R.; Schmidt-Parzefall, W.; Stiewe, J.; Werner, S.; Ehret, K.; Hofmann, W.; Hüpper, A.; Knöpfle, K. T.; Spengler, J.; Krieger, P.; Macfarlane, D. B.; Prentice, J. D.; Saull, P. R. B.; Tzamariudaki, K.; van de Water, R. G.; Yoon, T.-S.; Schneider, M.; Weseler, S.; Kernel, G.; Križan, P.; Križnič, E.; Podobnik, T.; Živko, T.; Balagura, V.; Barsuk, S.; Belyaev, I.; Chistov, R.; Danilov, M.; Gershtein, L.; Gershtein, Yu.; Golutyin, A.; Korolko, I.; Kostina, G.; Litvintsev, D.; Pakhlov, P.; Semenov, S.; Snizhko, A.; Tichomirov, I.; Zaitsev, Yu.; Argus Collaboration

    1995-02-01

    Using the ARGUS detector at the e +e - storage ring DORIS II at DESY, we have searched for decays b → sgluon through full reconstruction of a whole event. Two B overlineB decays were found with one of B meson decaying into a final state without charmed particles. We also obtained an upper limit of Br(B + → τ+ντ) of 1.04% at 90% CL.