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Sample records for development joint development

  1. 78 FR 14620 - Joint Development: Proposed Circular

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... published guidance on the eligibility of joint development activities for FTA funding. 72 FR 5788 (Feb. 7... review DOT's complete Privacy Act Statement published in the Federal Register on April 11, 2000 (65 FR... Federal Transit Administration Joint Development: Proposed Circular AGENCY: Federal Transit...

  2. Synovial Joints: from Development to Homeostasis

    PubMed Central

    Li, Tieshi; Tagliafierro, Lidia; Temple, Joseph D.; Willcockson, Helen H.; Ye, Ping; Esposito, Alessandra; Xu, Fuhua; Spagnoli, Anna

    2015-01-01

    Synovial joint morphogenesis occurs through the condensation of mesenchymal cells into a non-cartilaginous region known as interzone, and the specification of progenitor cells that commit to the articular fate. Although several signaling molecules are expressed by the interzone, the mechanism is poorly understood. For treatments of cartilage injuries, it is critical to discover the presence of joint progenitor cells in adult tissues and their expression gene pattern. Potential stem cells niches have been found in different joint regions, such as the surface zone of articular cartilage, synovium and groove of Ranvier. Inherited joint malformation as well as joint degenerating conditions are often associated with other skeletal defects, and may be seen as the failure of morphogenic factors to establish the correct microenvironment in cartilage and bone. Therefore, exploring how joints form can help us understand how cartilage and bone are damaged and to develop drugs to reactivate this developing mechanism. PMID:25431159

  3. Spherical Joint Piston and Connecting Rod Developed

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Under an interagency agreement with the Department of Energy, the NASA Lewis Research Center manages a Heavy-Duty Diesel Engine Technology (HDET) research program. The overall program objectives are to reduce fuel consumption through increased engine efficiency, reduce engine exhaust emissions, and provide options for the use of alternative fuels. The program is administered with a balance of research contracts, university research grants, and focused in-house research. The Cummins Engine Company participates in the HDET program under a cost-sharing research contract. Cummins is researching and developing in-cylinder component technologies for heavy-duty diesel engines. An objective of the Cummins research is to develop technologies for a low-emissions, 55-percent thermal efficiency (LE-55) engine. The best current-production engines in this class achieve about 46-percent thermal efficiency. Federal emissions regulations are driving this technology. Regulations for heavy duty diesel engines were tightened in 1994, more demanding emissions regulations are scheduled for 1998, and another step is planned for 2002. The LE-55 engine emissions goal is set at half of the 1998 regulation level and is consistent with plans for 2002 emissions regulations. LE-55 engine design requirements to meet the efficiency target dictate a need to operate at higher peak cylinder pressures. A key technology being developed and evaluated under the Cummins Engine Company LE-55 engine concept is the spherical joint piston and connecting rod. Unlike conventional piston and connecting rod arrangements which are joined by a pin forming a hinged joint, the spherical joint piston and connecting rod use a ball-and-socket joint. The ball-and-socket arrangement enables the piston to have an axisymmetric design allowing rotation within the cylinder. The potential benefits of piston symmetry and rotation are reduced scuffing, improved piston ring sealing, improved lubrication, mechanical and thermal

  4. Atypical molecular profile for joint development in the avian costal joint.

    PubMed

    Winslow, B B; Burke, A C

    2010-10-01

    Development of synovial joints involves generation of cartilaginous anlagen, formation of interzones between cartilage anlagen, and cavitation of interzones to produce fluid filled cavities. Interzone development is not fully understood, but interzones are thought to develop from skeletogenic cells that are inhibited from further chondrogenic development by a cascade of gene expression including Wnt and Bmp family members. We examined the development of the rarely studied avian costal joint to better understand mechanisms of joint development. The costal joint is found within ribs, is morphologically similar to the metatarsophalangeal joint, and undergoes cavitation in a similar manner. In contrast to other interzones, Wnt14/9a, Gdf5, Chordin, Barx1, and Bapx1 are absent from the costal joint interzone, consistent with the absence of active β-catenin and phosphorylated Smad 1/5/8. However Autotaxin and Noggin are expressed. The molecular profile of the costal joint suggests there are alternative mechanisms of interzone development. PMID:20730871

  5. Development and test of the ITER SC conductor joints

    SciTech Connect

    Gung, C. Y.; Jayakumar, R.; Manahan, R.; Martovetsky, N.; Michael, P.; Minervini, J.; Randall, A.

    1998-08-05

    Joints for the ITER superconducting Central Solenoid should perform in rapidly varying magnetic field with low losses and low DC resistance. This paper describes the design of the ITER joint and presents its assembly process. Two joints were built and tested at the PTF facility at MIT. Test results are presented; losses in transverse and parallel field and the DC performance are discussed. The developed joint demonstrates sufficient margin for baseline ITRR operating scenarios.

  6. Development and test of the ITER conductor joints

    SciTech Connect

    Martovetsky, N., LLNL

    1998-05-14

    Joints for the ITER superconducting Central Solenoid should perform in rapidly varying magnetic field with low losses and low DC resistance. This paper describes the design of the ITER joint and presents its assembly process. Two joints were built and tested at the PTF facility at MIT. Test results are presented, losses in transverse and parallel field and the DC performance are discussed. The developed joint demonstrates sufficient margin for baseline ITER operating scenarios.

  7. RSRM Nozzle-to-Case Joint J-leg Development

    NASA Technical Reports Server (NTRS)

    Albrechtsen, Kevin U.; Eddy, Norman F.; Ewing, Mark E.; McGuire, John R.

    2003-01-01

    Since the beginning of the Space Shuttle Reusable Solid Rocket Motor (RSRM) program, nozzle-to-case joint polysulfide adhesive gas paths have occurred on several flight motors. These gas paths have allowed hot motor gases to reach the wiper O-ring. Even though these motors continue to fly safely with this condition, a desire was to reduce such occurrences. The RSRM currently uses a J-leg joint configuration on case field joints and igniter inner and outer joints. The J-leg joint configuration has been successfully demonstrated on numerous RSRM flight and static test motors, eliminating hot gas intrusion to the critical O-ring seals on these joints. Using the proven technology demonstrated on the case field joints and igniter joints, a nozzle-to-case joint J-leg design was developed for implementation on RSRM flight motors. This configuration provides an interference fit with nozzle fixed housing phenolics at assembly, with a series of pressurization gaps incorporated outboard of the joint mating surface to aid in joint pressurization and to eliminate any circumferential flow in this region. The joint insulation is bonded to the nozzle phenolics using the same pressure sensitive adhesive used in the case field joints and igniter joints. An enhancement to the nozzle-to-case joint J-leg configuration is the implementation of a carbon rope thermal barrier. The thermal barrier is located downstream of the joint bondline and is positioned within the joint in a manner where any hot gas intrusion into the joint passes through the thermal barrier, reducing gas temperatures to a level that would not affect O-rings downstream of the thermal barrier. This paper discusses the processes used in reaching a final nozzle-to-case joint J-leg design, provides structural and thermal results in support of the design, and identifies fabrication techniques and demonstrations used in arriving at the final configuration.

  8. The Development of Action Planning in a Joint Action Context

    ERIC Educational Resources Information Center

    Paulus, Markus

    2016-01-01

    The ability to act jointly with another person is a fundamental requirement for participation in social life. The current study examines the development of action planning in a joint action context. In 4 experiments, 3-, 5-, and 7-year-old children as well as a group of adults (n = 196) interacted with another person to operate a novel apparatus.…

  9. Temperamental and Joint Attentional Predictors of Language Development

    ERIC Educational Resources Information Center

    Salley, Brenda J.; Dixon, Wallace E., Jr.

    2007-01-01

    Individual differences in child temperament have been associated with individual differences in language development. Similarly, relationships have been reported between early nonverbal social communication (joint attention) and both temperament and language. The present study examined whether individual differences in joint attention might…

  10. Children's Developing Commitments to Joint Goals

    ERIC Educational Resources Information Center

    Hamann, Katharina; Warneken, Felix; Tomasello, Michael

    2012-01-01

    This study investigated young children's commitment to a joint goal by assessing whether peers in collaborative activities continue to collaborate until all received their rewards. Forty-eight 2.5- and 3.5-year-old children worked on an apparatus dyadically. One child got access to her reward early. For the partner to benefit as well, this child…

  11. Development of design and analysis methodology for composite bolted joints

    NASA Astrophysics Data System (ADS)

    Grant, Peter; Sawicki, Adam

    1991-05-01

    This paper summarizes work performed to develop composite joint design methodology for use on rotorcraft primary structure, determine joint characteristics which affect joint bearing and bypass strength, and develop analytical methods for predicting the effects of such characteristics in structural joints. Experimental results have shown that bearing-bypass interaction allowables cannot be defined using a single continuous function due to variance of failure modes for different bearing-bypass ratios. Hole wear effects can be significant at moderate stress levels and should be considered in the development of bearing allowables. A computer program has been developed and has successfully predicted bearing-bypass interaction effects for the (0/+/-45/90) family of laminates using filled hole and unnotched test data.

  12. 24 CFR 570.411 - Joint Community Development Program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under 24 CFR part 570—Community Development Block Grants, subpart C—Eligible Activities. These... in accordance with 24 CFR part 58 must be carried out by the State or unit of general local... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Joint Community Development...

  13. 24 CFR 570.411 - Joint Community Development Program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under 24 CFR part 570—Community Development Block Grants, subpart C—Eligible Activities. These... in accordance with 24 CFR part 58 must be carried out by the State or unit of general local... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Joint Community Development...

  14. 24 CFR 570.411 - Joint Community Development Program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... under 24 CFR part 570—Community Development Block Grants, subpart C—Eligible Activities. These... in accordance with 24 CFR part 58 must be carried out by the State or unit of general local... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Joint Community Development...

  15. 24 CFR 570.411 - Joint Community Development Program.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under 24 CFR part 570—Community Development Block Grants, subpart C—Eligible Activities. These... in accordance with 24 CFR part 58 must be carried out by the State or unit of general local... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Joint Community Development...

  16. 24 CFR 570.411 - Joint Community Development Program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under 24 CFR part 570—Community Development Block Grants, subpart C—Eligible Activities. These... in accordance with 24 CFR part 58 must be carried out by the State or unit of general local... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Joint Community Development...

  17. Development of the bus joint for the ITER Central Solenoid

    SciTech Connect

    Martovetsky, Nicolai N; Irick, David Kim; Kenney, Steven J

    2013-01-01

    The terminations of the Central Solenoid (CS) modules are connected to the bus extensions by joints located outside the CS in the gap between the CS and Torodial Field (TF) assemblies. These joints have very strict space limitations. Low resistance is a common requirement for all ITER joints. In addition, the CS bus joints will experience and must be designed to withstand significant variation in the magnetic field of several tenths of a Tesla per second during initiation of plasma. The joint resistance is specified to be less than 4 nOhm. The joints also have to be soldered in the field and designed with the possibility to be installed and dismantled in order to allow cold testing in the cold test facility. We have developed coaxial joints that meet these requirements and have demonstrated the feasibility to fabricate and assemble them in the vertical configuration. We introduced a coupling cylinder with superconducting strands soldered to the surface of the cable that can be installed in the ITER assembly hall and at the Cold Test Facility. This cylinder serves as a transition area between the CS module and the bus extension. We made two racetrack samples and tested four bus joints in our Joint Test Apparatus. Resistance of the bus joints was measured by a decay method and by a microvoltmeter; the value of the current was measured by the Hall probes. This measurement method was verified in the previous tests. The resistance of the joints varied insignificantly from 1.5 to 2 nOhm. One of the challenges associated with a soldered joint is the inability to use corrosive chemicals that are difficult to clean. This paper describes our development work on cable preparation, chrome removal, compaction, soldering, and final assembly and presents the test results.

  18. Development of the Butt Joint for the ITER Central Solenoid

    SciTech Connect

    Martovetsky, N N

    2006-08-23

    The ITER Central Solenoid (CS) requires compact and reliable joints for its Cable-in-Conduit Conductor (CICC). The baseline design is a diffusion bonded butt joint. In such a joint the mating cables are compacted to a very low void fraction in a copper sleeve and then heat treated. After the heat treatment the ends are cut, polished and aligned against each other and then diffusion bonded under high compression in a vacuum chamber at 750 C. The jacket is then welded on the conductor to complete the joint, which remarkably does not require more room than a regular conductor. This joint design is based on a proven concept developed for the ITER CS Model Coil that was successfully tested in the previous R&D phase.

  19. Etiology of osteoarthritis: genetics and synovial joint development.

    PubMed

    Sandell, Linda J

    2012-02-01

    Osteoarthritis (OA) has a considerable hereditary component and is considered to be a polygenic disease. Data derived from genetic analyses and genome-wide screening of individuals with this disease have revealed a surprising trend: genes associated with OA tend to be related to the process of synovial joint development. Mutations in these genes might directly cause OA. In addition, they could also determine the age at which OA becomes apparent, the joint sites involved, the severity of the disease and how rapidly it progresses. In this Review, I propose that genetic mutations associated with OA can be placed on a continuum. Early-onset OA is caused by mutations in matrix molecules often associated with chondrodysplasias, whereas less destructive structural abnormalities or mutations confer increased susceptibility to injury or malalignment that can result in middle-age onset. Finally, mutations in molecules that regulate subtle aspects of joint development and structure lead to late-onset OA. In this Review, I discuss the genetics of OA in general, but focus on the potential effect of genetic mutations associated with OA on joint structure, the role of joint structure in the development of OA--using hip abnormalities as a model--and how understanding the etiology of the disease could influence treatment. PMID:22231237

  20. The Development of Educational Facilities through Joint Use Mechanisms.

    ERIC Educational Resources Information Center

    2000

    This paper was prepared as an outgrowth of a Getty Center symposium sponsored by New Schools Better Neighborhoods (NSBN) and its partner organizations in May 1999. The subject of joint use, generically meaning the development of K-12 education facilities in combination with other facilities such as parks or libraries, was broached at the Getty…

  1. The development of action planning in a joint action context.

    PubMed

    Paulus, Markus

    2016-07-01

    The ability to act jointly with another person is a fundamental requirement for participation in social life. The current study examines the development of action planning in a joint action context. In 4 experiments, 3-, 5-, and 7-year-old children as well as a group of adults (n = 196) interacted with another person to operate a novel apparatus. Their task was to hand the experimenter a tool with which she could activate 1 of 2 different effects on the apparatus. The elicitation of each effect required participants to grasp and insert the tool in a particular orientation. We assessed whether participants planned their grasping and reaching action in such a way that it enabled the partner to efficiently handle the tool, that is, anticipating the final end state of the joint activity. We found that 3-year-old children did not adjust their behavior to accommodate the other's action and that they did not increase their performance over multiple trials. Five- and 7-year-old children initially showed a tendency to plan their action in an egocentric manner (i.e., showed a form of egocentrism), but improved their joint action performance over time. Adult participants demonstrated joint action planning from the beginning. Interestingly, 3- and 5-year-old children were able to plan their grasp efficiently when acting alone on the apparatus. Yet, having first-hand experience with the task before acting with a partner did not facilitate performance in the joint action task for younger children. Overall, the study informs current approaches on the psychological basis and ontogenetic origins of joint action in childhood. (PsycINFO Database Record PMID:27337512

  2. Development of restraint material and tucked fabric joints

    NASA Technical Reports Server (NTRS)

    Mcmullen, J. M.

    1975-01-01

    A study was conducted to evaluate and select a suitable restraint material for the exterior of space suits pressurized to 4.0 PSID for normal operations, and to develop and improve tucked fabric joints for motions associated with the human shoulder, elbow, knee, waist, hip, ankle, and wrist. The many attributes of the end items are summarized to include structural integrity, simplicity, low maintenance, lightweight, high durability, low elongation, full range mobility, long life, and resistance to degradation in the operational environment.

  3. The joint DoD/DOE Munitions Technology Development Program

    SciTech Connect

    Repa, J.V. Jr.

    1994-08-01

    The joint Department of Defense (DoD)/Department of Energy (DOE) Munitions Technology Development Program is a cooperative, jointly funded effort of research and development to improve nonnuclear munitions technology across all service mission areas. This program is enabled under a Memorandum of Understanding, approved in 1985 between the DoD and the DOE, that tasks the nuclear weapons laboratories of the DOE to solve problems in conventional defense. The selection of the technical areas to be investigated is based on their importance to the military services, the needs that are common to the conventional and nuclear weapons programs, the expertise of the performing organization, and the perceived benefit to the overall national defense efforts. The research benefits both DoD and DOE programs; therefore, funding, planning, and monitoring are joint activities. Technology Coordination Groups (TCGs), organized by topical areas, serve as technology liaisons between the DoD and DOE for the exchange of information. The members of the TCGs are technical experts who meet semiannually in an informal workshop format to coordinate multiagency requirements, establish project plans, monitor technical activity, and develop classification guidance. A technical advisory committee of senior DoD and DOE managers administers the program and provides guidance on policy and strategy. The abstracts in this volume were collected from the technical progress report for fiscal year 1993. The annual report is organized by major technology areas. Telephone and fax numbers for the principal contacts are provided with each abstract.

  4. The design and development of a finger joint simulator.

    PubMed

    Joyce, Thomas J

    2016-05-01

    Artificial finger joints lack the long-term clinical success seen with hip and knee prostheses. In part, this can be explained by the challenges of rheumatoid arthritis, a progressive disease which attacks surrounding tissues as well as the joint itself. Therefore, the natural finger joints' biomechanics are adversely affected, and consequently, this imbalance due to subluxing forces further challenges any prosthesis. Many different designs of finger prosthesis have been offered over a period of greater than 50 years. Most of these designs have failed, and it is likely that many of these failures could have been identified had the prostheses been appropriately tested prior to implantation into patients. While finger joint simulators have been designed, arguably only those from a single centre have been able to reproduce clinical-type failures of the finger prostheses tested in them. This article describes the design and development of a finger simulator at Durham University, UK. It explains and justifies the engineering decisions made and thus the evolution of the finger simulator. In vitro results and their linkage to clinical-type failures are outlined to help to show the effectiveness of the simulator. Failures of finger implants in vivo continue to occur, and the need for appropriate in vitro testing of finger prostheses remains strong. PMID:26833697

  5. Temporomandibular joint computed tomography: development of a direct sagittal technique

    SciTech Connect

    van der Kuijl, B.; Vencken, L.M.; de Bont, L.G.; Boering, G. )

    1990-12-01

    Radiology plays an important role in the diagnosis of temporomandibular disorders. Different techniques are used with computed tomography offering simultaneous imaging of bone and soft tissues. It is therefore suited for visualization of the articular disk and may be used in patients with suspected internal derangements and other disorders of the temporomandibular joint. Previous research suggests advantages to direct sagittal scanning, which requires special positioning of the patient and a sophisticated scanning technique. This study describes the development of a new technique of direct sagittal computed tomographic imaging of the temporomandibular joint using a specially designed patient table and internal light visor positioning. No structures other than the patient's head are involved in the imaging process, and misleading artifacts from the arm or the shoulder are eliminated. The use of the scanogram allows precise correction of the condylar axis and selection of exact slice level.

  6. Joint United States/Japanese criticality data development program plan

    SciTech Connect

    Hachiya, Y.; Koyama, T.; Smolen, G.R.; Whitesides, G.E.

    1985-01-01

    A joint program on the subject of criticality data development has been initiated by the US Department of Energy and the Japan Power Reactor and Nuclear Fuel Development Corporation. A large number of critical experiments are planned to enhance the data base of mixed plutonium and uranium solution experiments. These data will be used to validate computer codes and cross-section libraries so that nuclear fuel recycling facilities can be designed to operate more safely and economically. The program also encompasses the development of a Subcriticality Measurement System which utilizes the /sup 252/Cf source-driven neutron noise analysis method. The system will be used to measure the subcriticality states of several experimental arrangements.

  7. New piston telemetry applied to spherical joint piston development

    SciTech Connect

    Wiczynski, P.D.; Varo, R.G.; Archuleta, S.A.; Galarno, M.J.

    1996-09-01

    A new telemetry system has been developed for temperature or strain measurements on a spherical joint piston. The system includes a piston mounted signal multiplexer and transmitter. A patented, piston mounted power generator operates in conjunction with a modified cylinder liner. The telemetry system is robust, having high inertia load capability and high environmental temperature operating capability. The telemetry system was installed and operated on an engine motoring test rig. Temperature signals were transmitted at engine speeds from 400 rpm to 2,100 rpm. Over 100 hours of high engine speed testing with oil sump temperatures up to 122 C were completed.

  8. A Longitudinal Analysis of Joint Attention and Language Development in Young Children with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Tek, Saime

    2010-01-01

    Joint attention (JA), which occurs when two individuals focus on the same object or event, plays a critical role in social and language development. Two major kinds of joint attention have been observed: response to joint attention (RJA), in which children follow the attentional focus of their social partners, and initiation of joint attention…

  9. 75 FR 57833 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit..., 2010......... Crowne Plaza Neurobiology-D November 19, 2010......... Crowne Plaza Pulmonary...

  10. 76 FR 66367 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit... Medicine. City. Surgery November 22, 2011... The Sheraton Crystal City. Endocrinology-A November...

  11. 77 FR 64598 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Biomedical Laboratory Research and Development and Clinical Science Research and Development Services..., 2012...... *VA Central Office. Cellular and Molecular Medicine...... November 19, 2012.........

  12. 75 FR 23847 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and ] Development Services Scientific Merit... & Molecular Medicine........ June 7, 2010 Hotel Palomar. Surgery June 7, 2010 Crowne Plaza....

  13. Joint Development of a Fourth Generation Single Crystal Superalloy

    NASA Technical Reports Server (NTRS)

    Walston, S.; Cetel, A.; MacKay, R.; OHara, K.; Duhl, D.; Dreshfield, R.

    2004-01-01

    A new, fourth generation, single crystal superalloy has been jointly developed by GE Aircraft Engines, Pratt & Whitney, and NASA. The focus of the effort was to develop a turbine airfoil alloy with long-term durability for use in the High Speed Civil Transport. In order to achieve adequate long-time strength improvements at moderate temperatures and retain good microstructural stability, it was necessary to make significant composition changes from 2nd and 3rd generation single crystal superalloys. These included lower chromium levels, higher cobalt and rhenium levels and the inclusion of a new alloying element, ruthenium. It was found that higher Co levels were beneficial to reducing both TCP precipitation and SRZ formation. Ruthenium caused the refractory elements to partition more strongly to the ' phase, which resulted in better overall alloy stability. The final alloy, EPM 102, had significant creep rupture and fatigue improvements over the baseline production alloys and had acceptable microstructural stability. The alloy is currently being engine tested and evaluated for advanced engine applications.

  14. Development of flexible joint for 500kV Al-sheathed O. F. cable

    SciTech Connect

    Komaba, T.; Kanai, K. ); Yoshida, S.; Shigetoshi, I.; Amano, K. )

    1992-10-01

    This paper reports on a flexible dimensionaly flush joint for 500kV aluminum-sheathed oil-filled cables capable of being assembled, pulled an installed in a similar manner to cables at site which has been developed. This joint is intended for use at intermediate points on long bridges or tunnels where local assembly and installation of conventional joints would be difficult. In developing the joint various novel and original techniques have been employed, including the flexible flush jointing of segmental conductors, the flexible jointing of paper insulation by a combination of wrapping-back and stepping methods, plus on-site aluminum sheath corrugating and sealing methods.

  15. 76 FR 1212 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Eligibility of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... areas of biomedical, behavioral and clinical science research. The panel meeting will be open to...

  16. 76 FR 79273 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Eligibility of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... biomedical, behavioral, and clinical science research. The panel meeting will be open to the public...

  17. 77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... following three panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... Medicine will meet on June 4, 2012, at the ] Sheraton Suites Old Town Alexandria and not at VA...

  18. 76 FR 24974 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... following four panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... 5, 2011..... 6 p.m.-10 p.m.... Crowne Plaza DC/Silver Spring. Medicine. June 6, 2011..... 8 a.m.-5...

  19. Southeast Asian seas: joint development of hydrocarbons in overlapping claim areas

    SciTech Connect

    Valencia, M.J.; Miyoshi, M.

    1986-01-01

    There are ocean areas of overlapping claims in Southeast Asia with significant petroleum potential which appear to be candidates for joint development, a process in which boundary disputes are set aside and the claimants jointly explore and exploit any hydrocarbon resources in such areas. Factors influencing the choice of joint development are delineated and described. The best candidate areas for joint development in Southeast Asia are the areas of overlap between Vietnam and Kampuchea in the eastern Gulf of Thailand and the Timor gap between Indonesia and Australia. The overlap between Vietnam and China in the Gulf of Tonkin and parts of the Dangerous Ground could become candidates for joint development if political relations change. Joint development schemes include agreement on the extent of the area in question, on the contractual system, and on the degree of autonomy and authority of the joint development body. Hypothetical schemes for joint development of some candidate areas are described. Although joint development is neither the optimal nor the permanent solution to unresolved boundaries, it will look increasingly attractive if the need for oil intensifies and precedents mount. 5 figures.

  20. [Joint morphogenesis and development of permanent articular cartilage].

    PubMed

    Ohta, Yoichi; Iwamoto, Masahiro

    2011-06-01

    During limb skeletogenesis progenitor mesenchymal cells aggregate at specific times and sites to form continuous precartilaginous condensations. With time the condensations undergo chondrogenesis and give rise to cartilaginous anlagen that exhibit incipient synovial joints at each end. A multitude of factors regulates subdivision into discrete skeletal elements and the formation, organization, morphogenesis and structure of the joints. This review summarizes recent advance of joint morphogenesis and actions of key players of joint and articular cartilage formation. In addition, we would like to discuss possible direction to translate basic research findings towards treatment of joint diseases. PMID:21628794

  1. Development of Thermal Barriers For Solid Rocket Motor Nozzle Joints

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.; Dunlap, Patrick H., Jr.

    2000-01-01

    Joints in the Space Shuttle solid rocket motors are sealed by O-rings to contain combustion gases inside the rocket that reach pressures of up to 900 psi and temperatures of up to 5500 F. To provide protection for the O-rings, the motors are insulated with either phenolic or rubber insulation. Gaps in the joints leading up to the O-rings are filled with polysulfide joint-fill compounds as an additional level of protection. The current RSRM nozzle-to-case joint design incorporating primary, secondary, and wiper O-rings experiences gas paths through the joint-fill compound to the innermost wiper O-ring in about one out of every seven motors. Although this does not pose a safety hazard to the motor, it is an undesirable condition that NASA and rocket manufacturer Thiokol want to eliminate. Each nozzle-to-case joint gas path results in extensive reviews and evaluation before flights can be resumed. Thiokol and NASA Marshall are currently working to improve the nozzle-to-case joint design by implementing a more reliable J-leg design that has been used successfully in the field and igniter joint. They are also planning to incorporate the NASA Glenn braided carbon fiber thermal barrier into the joint. The thermal barrier would act as an additional level of protection for the O-rings and allow the elimination of the joint-fill compound from the joint.

  2. Thermal Barriers Developed for Solid Rocket Motor Nozzle Joints

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.; Dunlap, Patrick H., Jr.

    2000-01-01

    Space shuttle solid rocket motor case assembly joints are sealed with conventional O-ring seals that are shielded from 5500 F combustion gases by thick layers of insulation and by special joint-fill compounds that fill assembly splitlines in the insulation. On a number of occasions, NASA has observed hot gas penetration through defects in the joint-fill compound of several of the rocket nozzle assembly joints. In the current nozzle-to-case joint, NASA has observed penetration of hot combustion gases through the joint-fill compound to the inboard wiper O-ring in one out of seven motors. Although this condition does not threaten motor safety, evidence of hot gas penetration to the wiper O-ring results in extensive reviews before resuming flight. The solid rocket motor manufacturer (Thiokol) approached the NASA Glenn Research Center at Lewis Field about the possibility of applying Glenn's braided fiber preform seal as a thermal barrier to protect the O-ring seals. Glenn and Thiokol are working to improve the nozzle-to-case joint design by implementing a more reliable J-leg design and by using a braided carbon fiber thermal barrier that would resist any hot gases that the J-leg does not block.

  3. Mouse genetic models for temporomandibular joint development and disorders

    PubMed Central

    Suzuki, A; Iwata, J

    2016-01-01

    The temporomandibular joint (TMJ) is a synovial joint essential for hinge and sliding movements of the mammalian jaw. Temporomandibular joint disorders (TMD) are dysregulations of the muscles or the TMJ in structure, function, and physiology, and result in pain, limited mandibular mobility, and TMJ noise and clicking. Although approximately 40–70% adults in the USA have at least one sign of TMD, the etiology of TMD remains largely unknown. Here, we highlight recent advances in our understanding of TMD in mouse models. PMID:26096083

  4. Genetic Influences on Temporomandibular Joint Development and Growth.

    PubMed

    Hinton, Robert J; Jing, Junjun; Feng, Jian Q

    2015-01-01

    The temporomandibular joint (TMJ) is a small synovial joint at which the mandible articulates with the skull during movements involved in speaking and mastication. However, the secondary cartilage lining its joint surfaces is indicative of a very different developmental history than limb cartilages. This review summarizes our current knowledge of genes that regulate the formation of primary components of the TMJ, as well as genes that regulate postnatal growth of the TMJ. Although the TMJ is regulated by some of the same genes that are important in limb joints, others appear unique to the TMJ or have different actions. Runx2, Sox9, and members of the TGF-β/BMP family are critical drivers of chondrogenesis during condylar cartilage morphogenesis, and Indian hedgehog (Ihh) is important for formation of the articular disc and cavitation. Osterix (Osx) is a critical regulator of endochondral bone formation during postnatal TMJ growth. PMID:26589922

  5. High current density, cryogenically cooled sliding electrical joint development

    SciTech Connect

    Murray, H.

    1986-09-01

    In the past two years, conceptual designs for fusion energy research devices have focussed on compact, high magnetic field configurations. The concept of sliding electrical joints in the large magnets allows a number of technical advantages including enhanced mechanical integrity, remote maintainability, and reduced project cost. The rationale for sliding electrical joints is presented. The conceptual configuration for this generation of experimental devices is highlghted by an approx. 20 T toroidal field magnet with a flat top conductor current of approx. 300 kA and a sliding electrical joint with a gross current density of approx. 0.6 kA/cm/sup 2/. A numerical model was used to map the conductor current distribution as a function of time and position in the conductor. A series of electrical joint arrangements were produced against the system code envelope constraints for a specific version of the Ignition Studies Project (ISP) which is designated as 1025.

  6. 77 FR 20489 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

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  7. 78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Research and Development and Clinical Science Research and Development Services Scientific Merit Review..., 2013; Pulmonary Medicine will meet on May 30, 2013, at the Sheraton Crystal City Hotel and not on...

  8. 78 FR 22622 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

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    Federal Register 2010, 2011, 2012, 2013, 2014

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  10. 78 FR 66992 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

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  11. 77 FR 23810 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Biomedical Laboratory Research and Development and Clinical Science Research and Development Services... May 24, 2012........ Sheraton Suites--Old Town Alexandria. Science-B Neurobiology-D May 24-25,...

  12. Development of Thermal Barriers for Solid Rocket Motor Nozzle Joints

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.; Dunlap, Patrick H., Jr.

    1999-01-01

    The Space Shuttle solid rocket motor case assembly joints are sealed using conventional 0-ring seals. The 5500+F combustion gases are kept a safe distance away from the seals by thick layers of insulation. Special joint-fill compounds are used to fill the joints in the insulation to prevent a direct flowpath to the seals. On a number of occasions. NASA has observed in several of the rocket nozzle assembly joints hot gas penetration through defects in the joint- fill compound. The current nozzle-to-case joint design incorporates primary, secondary and wiper (inner-most) 0-rings and polysulfide joint-fill compound. In the current design, 1 out of 7 motors experience hot gas to the wiper 0-ring. Though the condition does not threaten motor safety, evidence of hot gas to the wiper 0-ring results in extensive reviews before resuming flight. NASA and solid rocket motor manufacturer Thiokol are working to improve the nozzle-to-case joint design by implementing a more reliable J-leg design and a thermal barrier, This paper presents burn-resistance, temperature drop, flow and resiliency test results for several types of NASA braided carbon-fiber thermal barriers. Burn tests were performed to determine the time to burn through each of the thermal barriers when exposed to the flame of an oxy-acetylene torch (5500 F), representative of the 5500 F solid rocket motor combustion temperatures. Thermal barriers braided out of carbon fibers endured the flame for over 6 minutes, three times longer than solid rocket motor burn time. Tests were performed on two thermal barrier braid architectures, denoted Carbon-3 and Carbon-6, to measure the temperature drop across and along the barrier in a compressed state when subjected to the flame of an oxyacetylene torch. Carbon-3 and Carbon-6 thermal barriers were excellent insulators causing temperature drops through their diameter of up to a 2800 and 2560 F. respectively. Gas temperature 1/4" downstream of the thermal barrier were within the

  13. Development of assembly and joint concepts for erectable space structures

    NASA Technical Reports Server (NTRS)

    Jacquemin, G. G.; Bluck, R. M.; Grotbeck, G. H.; Johnson, R. R.

    1980-01-01

    The technology associated with the on-orbit assembly of tetrahedral truss platforms erected of graphite epoxy tapered columns is examined. Associated with the assembly process is the design and fabrication of nine member node joints. Two such joints demonstrating somewhat different technology were designed and fabricated. Two methods of automatic assembly using the node designs were investigated, and the time of assembly of tetrahedral truss structures up to 1 square km in size was estimated. The effect of column and node joint packaging on the Space Shuttle cargo bay is examined. A brief discussion is included of operating cost considerations and the selection of energy sources. Consideration was given to the design assembly machines from 5 m to 20 m. The smaller machines, mounted on the Space Shuttle, are deployable and restowable. They provide a means of demonstrating the capabilities of the concept and of erecting small specialized platforms on relatively short notice.

  14. Development of a Enhanced Thermal Barrier for RSRM Nozzle Joints

    NASA Technical Reports Server (NTRS)

    Bauer, P. H.; McCool, A. (Technical Monitor)

    2000-01-01

    A carbon fiber rope is being considered as replacement for the RTV thermal barrier that is currently used to protect o-rings in RSRM nozzle joints, Performance requirements include its ability to cool propellant gases filter slag and particulates, and conform to various joint assembly conditions as well as dynamic flight motion. Testing has shown its superior heat resistance, even in oxidative and corrosive environments. Testing has also demonstrated excellent performance of this system in sub-scale motors. Cold flow testing, has demonstrated its ability to conform to motor dynamics. Manufacture and assembly testing have demonstrated the ease of gland machining as well as assembly in a full-scale nozzle.

  15. Partnerships between Public Schools and Private Developers. A Report of the Joint Legislative Audit Committee.

    ERIC Educational Resources Information Center

    Armoudian, Maria

    The California Legislature's Joint Legislative Audit Committee investigated several "joint venture" partnerships between school districts and the private sector to develop school district-owned properties to determine the feasibility of such innovative school construction projects. This report presents findings from seven of these public/private…

  16. A Longitudinal Study of Joint Attention and Language Development in Autistic Children.

    ERIC Educational Resources Information Center

    Mundy, Peter; And Others

    1990-01-01

    Compared to age-matched and language-matched controls, 15 autistic children (mean age of 45 months) who were administered the Early Social-Communication Scales displayed deficits in gestural joint attention skills in 2 testing sessions 13 months apart. The measure of gestural nonverbal joint attention predicted language development in subjects.…

  17. Development of a hip joint model for finite volume simulations.

    PubMed

    Cardiff, P; Karač, A; FitzPatrick, D; Ivanković, A

    2014-01-01

    This paper establishes a procedure for numerical analysis of a hip joint using the finite volume method. Patient-specific hip joint geometry is segmented directly from computed tomography and magnetic resonance imaging datasets and the resulting bone surfaces are processed into a form suitable for volume meshing. A high resolution continuum tetrahedral mesh has been generated, where a sandwich model approach is adopted; the bones are represented as a stiffer cortical shells surrounding more flexible cancellous cores. Cartilage is included as a uniform thickness extruded layer and the effect of layer thickness is investigated. To realistically position the bones, gait analysis has been performed giving the 3D positions of the bones for the full gait cycle. Three phases of the gait cycle are examined using a finite volume based custom structural contact solver implemented in open-source software OpenFOAM. PMID:24141555

  18. Development of process to control residual stress distribution of butt weld joint of cylinder

    SciTech Connect

    Nayama, Michisuke; Sakamoto, Naruo; Akitomo, Norio; Toyoda, Masao

    1995-12-31

    The authors develop new process to control residual stress distribution of butt weld joint of cylinder. This process, which is heating circularly at both side of butt weld joint and letting cool, can reduce tensile residual stress on inner surface near weld joint by operation from only outside of cylinder and its required temperature rise of this process is lower than ordinary PWHT (Post Weld Heat Treatment) process. This paper describes the procedure and conditions of the process named ``both side heating`` by authors. The appropriate range of process conditions to get sufficient effect is confirmed by FEM stress history analysis and experiment in this paper. Experiments show that the inner residual stress near weld is reduced to compression from over yield stress at as weld condition in austenitic stainless steel pipe to pipe joints, pipe to elbow joints and pipe to valve joint after application of the process.

  19. Development of molded, coated fabric joints: Fabric construction criteria for a spacesuit elbow joint

    NASA Technical Reports Server (NTRS)

    Olson, L. H.

    1981-01-01

    The design and fabrication of a molded, coated fabric elbow joint capable of operating reliably at 8 psi internal pressure for extended periods of flexure is considered. The overall design of the joint includes: (1) selection of heatsettable fiber of sufficient strengths; (2) choosing an optimum fabric construction; (3) a fatigue resistant; flexible coating; and (4) a molding technique. A polyester yarn of type 56 Dacron and a urethane coating system were selected. The relationships between yarn and weave parameters which lead to an optimum fabric construction for the 8 psi elbow joint are defined.

  20. Development of Synovial Membrane in the Temporomandibular Joint of the Human Fetus

    PubMed Central

    Tedesco, R.C.; Arraéz-Aybar, L.A.; Klein, O.; Mérida-Velasco, J.R.; Alonso, L.G.

    2015-01-01

    The development of the synovial membrane was analyzed in serial sections of 21 temporomandibular joints of human fetuses at 9 to 13 weeks of gestation. Sections of two fetuses at 12 weeks of development were used to perform immunohistochemical expression of the markers CD68 and Hsp27 on the synovial lining. Macrophage-like type A and fibroblast-like type B cells, which express CD68 and Hsp27, respectively, were observed at the twelfth week of development. Our results suggest that the development of the synovial membrane is related to the vascularization of the joint and the formation of the articular cavities. PMID:26708184

  1. Development

    ERIC Educational Resources Information Center

    Childress, Dana C.; Raver, Sharon A.; Michalek, Anne M. P.; Wilson, Corinne L.

    2013-01-01

    All eligible infants and toddlers who receive early intervention services under Part C of Individuals with Disabilities Education Act are entitled to service coordination. To examine the effectiveness of one state's service coordination training and its impact on knowledge and skill development, a pretest--posttest design with follow-up…

  2. Working better together: joint leadership development for doctors and managers

    PubMed Central

    Kelly, Nicola

    2014-01-01

    Traditionally, there have been tensions between frontline healthcare professionals and managers, with well-known stereotypes of difficult consultants and pen-pushing managers. Many junior doctors have limited management experience and have often never even met a manager prior to taking on a consultant role. Based on a successful programme pioneered by Dr Robert Klaber (Imperial, London) we have set-up an innovative scheme for Birmingham Children's Hospital, pairing junior doctors and managers to learn and work together. Our aim was to cultivate positive attitudes and understanding between the two groups, break down inter-professional barriers, and to provide practical leadership experience and education. We recruited 60 managers and doctors to participate in shadowing, conversation, and quality improvement projects. Thought-provoking online materials, blogs, socials, and popular monthly workshops consisting of patient-focused debate and discussion around key leadership themes, have helped to support learning and cement shared values. Formal evaluation has demonstrated an improvement in how participants perceive their knowledge and ability based on key NHS Leadership Framework competencies. Participant feedback has been extremely positive, and everyone plans to continue to incorporate Paired Learning into their continuing professional development. We are now embedding Paired Learning in the on-going educational programme offered at Birmingham Children's Hospital, whilst looking at extending the scheme to include different professional groups and other trusts across the region and nationally.

  3. Development of the Joint NASA/NCAR General Circulation Model

    NASA Technical Reports Server (NTRS)

    Lin, S.-J.; Rood, R. B.

    1999-01-01

    The Data Assimilation Office at NASA/Goddard Space Flight Center is collaborating with NCAR/CGD in an ambitious proposal for the development of a unified climate, numerical weather prediction, and chemistry transport model which is suitable for global data assimilation of the physical and chemical state of the Earth's atmosphere. A prototype model based on the NCAR CCM3 physics and the NASA finite-volume dynamical core has been built. A unique feature of the NASA finite-volume dynamical core is its advanced tracer transport algorithm on the floating Lagrangian control-volume coordinate. The model currently has a highly idealized ozone production/loss chemistry derived from the observed 2D (latitude-height) climatology of the recent decades. Nevertheless, the simulated horizontal wave structure of the total ozone is in good qualitative agreement with the observed (TOMS). Long term climate simulations and NWP experiments have been carried out. Current up to date status and futur! e plan will be discussed in the conference.

  4. Working better together: joint leadership development for doctors and managers.

    PubMed

    Kelly, Nicola

    2014-01-01

    Traditionally, there have been tensions between frontline healthcare professionals and managers, with well-known stereotypes of difficult consultants and pen-pushing managers. Many junior doctors have limited management experience and have often never even met a manager prior to taking on a consultant role. Based on a successful programme pioneered by Dr Robert Klaber (Imperial, London) we have set-up an innovative scheme for Birmingham Children's Hospital, pairing junior doctors and managers to learn and work together. Our aim was to cultivate positive attitudes and understanding between the two groups, break down inter-professional barriers, and to provide practical leadership experience and education. We recruited 60 managers and doctors to participate in shadowing, conversation, and quality improvement projects. Thought-provoking online materials, blogs, socials, and popular monthly workshops consisting of patient-focused debate and discussion around key leadership themes, have helped to support learning and cement shared values. Formal evaluation has demonstrated an improvement in how participants perceive their knowledge and ability based on key NHS Leadership Framework competencies. Participant feedback has been extremely positive, and everyone plans to continue to incorporate Paired Learning into their continuing professional development. We are now embedding Paired Learning in the on-going educational programme offered at Birmingham Children's Hospital, whilst looking at extending the scheme to include different professional groups and other trusts across the region and nationally. PMID:27493738

  5. Joint Attention Behaviours and Vocabulary Development in Children with Down Syndrome

    ERIC Educational Resources Information Center

    Zampini, L.; Salvi, A.; D'Odorico, L.

    2015-01-01

    Background: Because of their difficulties in language development, various studies have focussed on the precursors of linguistic skills in children with Down syndrome. However, data on the predictive role of joint attention on language development in this population are inconsistent. The present study aimed to analyse attention behaviours in a…

  6. Sacroiliac joint dysfunction as a reason for the development of acetabular retroversion: a new theory.

    PubMed

    Cibulka, Michael T

    2014-05-01

    Acetabular retroversion has been recently implicated as an important factor in the development of femoral acetabular impingement and hip osteoarthritis. The proper function of the hip joint requires that the anatomic features of the acetabulum and femoral head complement one another. In acetabular retroversion, the alignment of the acetabulum is altered where it opens in a posterolaterally instead of anterior direction. Changes in acetabular orientation can occur with alterations in pelvic tilt (anterior/posterior), and pelvic rotation (left/right). An overlooked problem that alters pelvic tilt and rotation, often seen by physical therapists, is sacroiliac joint dysfunction. A unique feature that develops in patients with sacroiliac joint dysfunction (SIJD) is asymmetry between the left and right innominate bones that can alter pelvic tilt and rotation. This article puts forth a theory suggesting that acetabular retroversion may be produced by sacroiliac joint dysfunction. PMID:24350878

  7. From Interactions to Conversations: The Development of Joint Engagement during Early Childhood

    PubMed Central

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke

    2013-01-01

    This research traces the development of symbol-infused joint engagement during mother-child interactions into the preschool years. Forty-nine children, who had been previously observed as toddlers (Adamson, Bakeman, & Deckner, 2004), were systematically observed during interactions with their mothers at ages 3½, 4½, and 5½ during activities related to the past and future, internal states, and graphic systems. Although the amount of symbol-infused joint engagement reached a ceiling by 3½, its focus continued to became more complex and its form more balanced. Individual differences in children’s symbol-infused joint engagement were stable across four years. These findings highlight both how joint engagement is transformed as conversational skills develop and how it remains rooted in earlier interactions and supported by caregiver’s actions. PMID:24266591

  8. Morphogen-based simulation model of ray growth and joint patterning during fin development and regeneration.

    PubMed

    Rolland-Lagan, Anne-Gaëlle; Paquette, Mathieu; Tweedle, Valerie; Akimenko, Marie-Andrée

    2012-03-01

    The fact that some organisms are able to regenerate organs of the correct shape and size following amputation is particularly fascinating, but the mechanism by which this occurs remains poorly understood. The zebrafish (Danio rerio) caudal fin has emerged as a model system for the study of bone development and regeneration. The fin comprises 16 to 18 bony rays, each containing multiple joints along its proximodistal axis that give rise to segments. Experimental observations on fin ray growth, regeneration and joint formation have been described, but no unified theory has yet been put forward to explain how growth and joint patterns are controlled. We present a model for the control of fin ray growth during development and regeneration, integrated with a model for joint pattern formation, which is in agreement with published, as well as new, experimental data. We propose that fin ray growth and joint patterning are coordinated through the interaction of three morphogens. When the model is extended to incorporate multiple rays across the fin, it also accounts for how the caudal fin acquires its shape during development, and regains its correct size and shape following amputation. PMID:22318227

  9. Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development

    PubMed Central

    Brunt, Lucy H.; Norton, Joanna L.; Bright, Jen A.; Rayfield, Emily J.; Hammond, Chrissy L.

    2015-01-01

    Abnormal joint morphogenesis is linked to clinical conditions such as Developmental Dysplasia of the Hip (DDH) and to osteoarthritis (OA). Muscle activity is known to be important during the developmental process of joint morphogenesis. However, less is known about how this mechanical stimulus affects the behaviour of joint cells to generate altered morphology. Using zebrafish, in which we can image all joint musculoskeletal tissues at high resolution, we show that removal of muscle activity through anaesthetisation or genetic manipulation causes a change to the shape of the joint between the Meckel's cartilage and Palatoquadrate (the jaw joint), such that the joint develops asymmetrically leading to an overlap of the cartilage elements on the medial side which inhibits normal joint function. We identify the time during which muscle activity is critical to produce a normal joint. Using Finite Element Analysis (FEA), to model the strains exerted by muscle on the skeletal elements, we identify that minimum principal strains are located at the medial region of the joint and interzone during mouth opening. Then, by studying the cells immediately proximal to the joint, we demonstrate that biomechanical strain regulates cell orientation within the developing joint, such that when muscle-induced strain is removed, cells on the medial side of the joint notably change their orientation. Together, these data show that biomechanical forces are required to establish symmetry in the joint during development. PMID:26253758

  10. Development and evaluation of a musculoskeletal model of the elbow joint complex

    NASA Technical Reports Server (NTRS)

    Gonzalez, Roger V.; Hutchins, E. L.; Barr, Ronald E.; Abraham, Lawrence D.

    1993-01-01

    This paper describes the development and evaluation of a musculoskeletal model that represents human elbow flexion-extension and forearm pronation-supination. The length, velocity, and moment arm for each of the eight musculotendon actuators were based on skeletal anatomy and position. Musculotendon parameters were determined for each actuator and verified by comparing analytical torque-angle curves with experimental joint torque data. The parameters and skeletal geometry were also utilized in the musculoskeletal model for the analysis of ballistic elbow joint complex movements. The key objective was to develop a computational model, guided by parameterized optimal control, to investigate the relationship among patterns of muscle excitation, individual muscle forces, and movement kinematics. The model was verified using experimental kinematic, torque, and electromyographic data from volunteer subjects performing ballistic elbow joint complex movements.

  11. 77 FR 41164 - Joint Subcommittee on Aquaculture Research and Development Strategic Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... Agricultural Research Service DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC007 Joint Subcommittee on Aquaculture Research and Development Strategic Plan AGENCIES: Agricultural... request for comments. SUMMARY: NOAA and U.S. Department of Agriculture Agricultural Research Service...

  12. From Interactions to Conversations: The Development of Joint Engagement during Early Childhood

    ERIC Educational Resources Information Center

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke

    2014-01-01

    This research traces the development of symbol-infused joint engagement during mother-child interactions into the preschool years. Forty-nine children, who had been previously observed as toddlers (L. B. Adamson, R. Bakeman, & D. F. Deckner), [Adamson, L. B., 2004], were systematically observed during interactions with their mothers at ages…

  13. 15 CFR 295.23 - Dissolution of joint research and development ventures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Dissolution of joint research and development ventures. 295.23 Section 295.23 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  14. 15 CFR 295.23 - Dissolution of joint research and development ventures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Dissolution of joint research and development ventures. 295.23 Section 295.23 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  15. 15 CFR 295.23 - Dissolution of joint research and development ventures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Dissolution of joint research and development ventures. 295.23 Section 295.23 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  16. 15 CFR 295.23 - Dissolution of joint research and development ventures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Dissolution of joint research and development ventures. 295.23 Section 295.23 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  17. 15 CFR 295.23 - Dissolution of joint research and development ventures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Dissolution of joint research and development ventures. 295.23 Section 295.23 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST...

  18. Design and technical support for development of a molded fabric space suit joint

    NASA Technical Reports Server (NTRS)

    Olson, L. Howard

    1994-01-01

    NASA Ames Research Center has under design a new joint or element for use in a space suit. The design concept involves molding a fabric to a geometry developed at Ames. Unusual characteristics of this design include the need to produce a fabric molding draw ratio on the order of thirty percent circumferentially on the surface. Previous work done at NASA on molded fabric joints has shown that standard, NASA qualified polyester fabrics as are currently available in the textile industry for use in suits have a maximum of about fifteen percent draw ratio. NASA has done the fundamental design for a prototype joint and of a mold which would impart the correct shape to the fabric support layer of the joint. NASA also has the capability to test a finished product for suitability and reliability. Responsibilities resting with Georgia Tech in the design effort for this project are textile related, namely fiber selection, fabric design to achieve the properties of the objective design, and determining production means and sources for the fabrics. The project goals are to produce a prototype joint using the NASA design for evaluation of effectiveness by NASA, and to establish the sources and specifications which would allow reliable and repeatable production of the joint.

  19. Supporting the joint warfighter by development, training, and fielding of man-portable UGVs

    NASA Astrophysics Data System (ADS)

    Ebert, Kenneth A.; Stratton, Benjamin V.

    2005-05-01

    The Robotic Systems Pool (RSP), sponsored by the Joint Robotics Program (JRP), is an inventory of small robotic systems, payloads, and components intended to expedite the development and integration of technology into effective, supportable, fielded robotic assets. The RSP loans systems to multiple users including the military, first-responders, research organizations, and academia. These users provide feedback in their specific domain, accelerating research and development improvements of robotic systems, which in turn allow the joint warfighter to benefit from such changes more quickly than from traditional acquisition cycles. Over the past year, RSP assets have been used extensively for pre-deployment operator and field training of joint Explosive Ordnance Disposal (EOD) teams, and for the training of Navy Reservist repair technicians. These Reservists are part of the Robotic Systems Combat Support Platoon (RSCSP), attached to Space and Naval Warfare Systems Center, San Diego. The RSCSP maintains and repairs RSP assets and provides deployable technical support for users of robotic systems. Currently, a small team from the RSCSP is deployed at Camp Victory repairing and maintaining man-portable unmanned ground vehicles (UGVs) used by joint EOD teams in Operation Iraqi Freedom. The focus of this paper is to elaborate on the RSP and RSCSP and their role as invaluable resources for spiral development in the robotics community by gaining first-hand technical feedback from the warfighter and other users.

  20. Development of Bonded Joint Technology for a Rigidizable-Inflatable Deployable Truss

    NASA Technical Reports Server (NTRS)

    Smeltzer, Stanley S., III

    2006-01-01

    Microwave and Synthetic Aperture Radar antenna systems have been developed as instrument systems using truss structures as their primary support and deployment mechanism for over a decade. NASA Langley Research Center has been investigating fabrication, modular assembly, and deployment methods of lightweight rigidizable/inflatable linear truss structures during that time for large spacecraft systems. The primary goal of the research at Langley Research Center is to advance these existing state-of-the-art joining and deployment concepts to achieve prototype system performance in a relevant space environment. During 2005, the development, fabrication, and testing of a 6.7 meter multi-bay, deployable linear truss was conducted at Langley Research Center to demonstrate functional and precision metrics of a rigidizable/inflatable truss structure. The present paper is intended to summarize aspects of bonded joint technology developed for the 6.7 meter deployable linear truss structure while providing a brief overview of the entire truss fabrication, assembly, and deployment methodology. A description of the basic joint design, surface preparation investigations, and experimental joint testing of component joint test articles will be described. Specifically, the performance of two room temperature adhesives were investigated to obtain qualitative data related to tube folding testing and quantitative data related to tensile shear strength testing. It was determined from the testing that a polyurethane-based adhesive best met the rigidizable/inflatable truss project requirements.

  1. Design and development testing of the bonded joint between a typical launch vehicle attachment ring and CFRP thrust cone

    NASA Astrophysics Data System (ADS)

    Sharkey, J. T.; Nayler, G. H. F.; Reynolds, J.

    1986-02-01

    The development of the principal structural joint of a Shuttle payload is described. The joint is subjected to large tension and compression loads due to the spacecraft being cantilevered perpendicular to the direction of flight of the launch vehicle. Finite element modeling was included in the investigation of joint designs. A bonded and bolted double lap shear configuration was chosen. Manufacturing and inspection methods were developed and testing of joint samples was undertaken including static, thermal and fatigue loading. The static test results were used to determine the design allowable strength of the joint.

  2. Analysis of EDZ Development of Columnar Jointed Rock Mass in the Baihetan Diversion Tunnel

    NASA Astrophysics Data System (ADS)

    Hao, Xian-Jie; Feng, Xia-Ting; Yang, Cheng-Xiang; Jiang, Quan; Li, Shao-Jun

    2016-04-01

    Due to the time dependency of the crack propagation, columnar jointed rock masses exhibit marked time-dependent behaviour. In this study, in situ measurements, scanning electron microscope (SEM), back-analysis method and numerical simulations are presented to study the time-dependent development of the excavation damaged zone (EDZ) around underground diversion tunnels in a columnar jointed rock mass. Through in situ measurements of crack propagation and EDZ development, their extent is seen to have increased over time, despite the fact that the advancing face has passed. Similar to creep behaviour, the time-dependent EDZ development curve also consists of three stages: a deceleration stage, a stabilization stage, and an acceleration stage. A corresponding constitutive model of columnar jointed rock mass considering time-dependent behaviour is proposed. The time-dependent degradation coefficient of the roughness coefficient and residual friction angle in the Barton-Bandis strength criterion are taken into account. An intelligent back-analysis method is adopted to obtain the unknown time-dependent degradation coefficients for the proposed constitutive model. The numerical modelling results are in good agreement with the measured EDZ. Not only that, the failure pattern simulated by this time-dependent constitutive model is consistent with that observed in the scanning electron microscope (SEM) and in situ observation, indicating that this model could accurately simulate the failure pattern and time-dependent EDZ development of columnar joints. Moreover, the effects of the support system provided and the in situ stress on the time-dependent coefficients are studied. Finally, the long-term stability analysis of diversion tunnels excavated in columnar jointed rock masses is performed.

  3. Development of High Temperature Dissimilar Joint Technology for Fission Surface Power Systems

    NASA Technical Reports Server (NTRS)

    Locci, Ivan E.; Bowman, Cheryl L.; Gabb, Timothy P.

    2009-01-01

    NASA is developing fission surface power (FSP) system technology as a potential option for use on the surface of the moon or Mars. The goal is to design a robust system that takes full advantage of existing materials data bases. One of the key components of the power conversion system is the hot-side Heat Exchanger (HX). One possible design for this heat exchanger requires a joint of the dissimilar metals 316L stainless steel and Inconel 718, which must sustain extended operation at high temperatures. This study compares two joining techniques, brazing and diffusion bonding, in the context of forming the requisite stainless steel to superalloy joint. The microstructures produced by brazing and diffusion bonding, the effect of brazing cycle on the mechanical tensile properties of the alloys, and the strength of several brazed joints will be discussed.

  4. Characterization of bulk stainless steel joints developed through microwave hybrid heating

    SciTech Connect

    Bansal, Amit; Sharma, Apurbba Kumar; Kumar, Pradeep; Das, Shantanu

    2014-05-01

    Processing of metallic materials through microwave heating is a challenging area of research. In the present work, joining of stainless steel-316 to stainless steel-316 in the bulk form has been carried out by placing stainless steel-316 powder at the interface and through targeted heating using microwave hybrid heating. The trials were carried out in a multimode microwave applicator at a frequency of 2.45 GHz and power 900 W. The developed joints were characterized using X-ray diffraction, field emission scanning electron microscopy equipped with energy dispersive X-ray spectroscope and measurement of Vicker's microhardness, porosity and tensile strength. The X-ray diffraction spectrum of the developed joint shows the presence of chromium carbide, iron carbide and iron silicide phases that eventually contribute to enhancement of the microhardness of the joint. The scanning electron microscope micrographs confirm classical metallurgical bonding between the substrate and the interface (molten powder) layer; the epitaxial growth rate was observed adjacent to the fusion zone. The average observed Vicker's microhardness in the joint zone on the grain boundary was significantly higher than that inside the grains due to the presence of various hard phases at the grain boundaries. Evaluation of the tensile strength of the joints showed an average ultimate tensile strength of 425.0 MPa with an average elongation of 9.44%. - Highlights: • Joining of stainless steel (SS-316) plates using microwave hybrid heating • Epitaxial growth rate observed adjacent to the fusion zone of welded joint • The ultimate tensile strength of the order of 425.0 MPa with 9.44% elongation.

  5. Structural development of laminar flow control aircraft chordwise wing joint designs

    NASA Technical Reports Server (NTRS)

    Fischler, J. E.; Jerstad, N. M.; Gallimore, F. H., Jr.; Pollard, T. J.

    1989-01-01

    For laminar flow to be achieved, any protuberances on the surface must be small enough to avoid transition to turbulent flow. However, the surface must have joints between the structural components to allow assembly or replacement of damaged parts, although large continuous surfaces can be utilized to minimize the number the number of joints. Aircraft structural joints usually have many countersunk bolts or rivets on the outer surface. To maintain no mismatch on outer surfaces, it is desirable to attach the components from the inner surface. It is also desirable for the panels to be interchangeable, without the need for shims at the joint, to avoid surface discontinuities that could cause turbulence. Fabricating components while pressing their outer surfaces against an accurate mold helps to ensure surface smoothness and continuity at joints. These items were considered in evaluating the advantages and disadvantages of the joint design concepts. After evaluating six design concepts, two of the leading candidates were fabricated and tested using many small test panels. One joint concept was also built and tested using large panels. The small and large test panel deflections for the leading candidate designs at load factors up to +1.5 g's were well within the step and waviness requirements for avoiding transition.The small panels were designed and tested for compression and tension at -65 F, at ambient conditions, and at 160 F. The small panel results for the three-rib and the sliding-joint concepts indicated that they were both acceptable. The three-rib concept, with tapered splice plates, was considered to be the most practical. A modified three-rib joint that combined the best attributes of previous candidates was designed, developed, and tested. This improved joint met all of the structural strength, surface smoothness, and waviness criteria for laminar flow control (LFC). The design eliminated all disadvantages of the initial three-rib concept except for

  6. Development of integrated insulation joint for cooling pipe in tokamak reactor

    NASA Astrophysics Data System (ADS)

    Nishio, Satoshi; Abe, Tetsuya; Kawamura, Masashi; Yamazaki, Seiichiro

    1994-08-01

    In a tokamak fusion reactor, an electrically insulated part is needed for an in-vessel piping system in order to break an electric circuit loop. When a closed loop is formed in the piping system, large induced electromagnetic forces during a plasma disruption (rapid plasma current quench) could give damages on the piping system. Ceramic brazing joint is a conventional method for the electric circuit break, but an application to the fusion reactor is not feasible due to its brittleness. Here, a stainless steel / ceramics / stainless steel functionally gradient material (FGM) has been proposed and developed as an integrated insulation joint of the piping system. Both sides of the joint can be welded to the main pipes, and expected to be reliable even in the fusion reactor environment. When the FGM joint is manufactured by way of a sintering process, a residual thermal stress is the key issue. Through detailed computations of the residual thermal stress and several trial productions, tubular elements of FGM joints have been successfully manufactured.

  7. Development and evaluation of a musculoskeletal model of the elbow joint complex.

    PubMed

    Gonzalez, R V; Hutchins, E L; Barr, R E; Abraham, L D

    1996-02-01

    This paper describes the development and evaluation of a musculoskeletal model that represents human elbow flexion-extension and forearm pronation-supination. The length, velocity, and moment arm for each of the eight musculotendon actuators were based on skeletal anatomy and joint position. Musculotendon parameters were determined for each actuator and verified by comparing analytical moment-angle curves with experimental joint torque data. The parameters and skeletal geometry were also utilized in the musculoskeletal model for the analysis of ballistic (rapid-directed) elbow joint complex movements. The key objective was to develop a computational model, guided by parameterized optimal control, to investigate the relationship among patterns of muscle excitation, individual muscle forces, and to determine the effects of forearm and elbow position on the recruitment of individual muscles during a variety of ballistic movements. The model was partially verified using experimental kinematic, torque, and electromyographic data from volunteer subjects performing both isometric and ballistic elbow joint complex movements. This verification lends credibility to the time-varying muscle force predictions and the recruitment of muscles that contribute to both elbow flexion-extension and forearm pronation-supination. PMID:8833072

  8. Statistic study on developing condition of horizontal columnar joints in Jeongja and Eupchon beach areas, SE Korea

    NASA Astrophysics Data System (ADS)

    Jin, K.; Kim, Y.; Geologic Structure; Geohazard Research Group

    2010-12-01

    Unusual patterns of columnar joints are developed in Tertiary volcanic rocks along the Jeongja and Eupchon beach areas, SE Korea. The columnar joints represent various features in shape and orientation, including horizontal and inclined column distribution. The shape and orientation of columnar joints were statistically analyzed to understand the causes of the unusual column patterns. For this purpose, the shape of the column face perpendicular to the column direction and the trend and plunge of the column are analyzed. Most columnar joints in the study areas have five or six column faces, and the column diameter perpendicular to the column direction is in a range of between 30 to 50 cm. Columnar joints generally develop vertically due to cooling from both top and bottom surfaces. However, unusual horizontal and inclined columnar joints are observed in the study areas. Therefore, the horizontal and inclined columnar joints developed in the study areas may suggest abnormal cooling condition. The volcanic rocks in the study areas intruded or extruded in late Miocene (22-16 Ma), which coincides with a period of high sea level in the Miocene. The sea level is almost the same as the present sea level. This may suggest that the unusual columnar joint patterns that have developed in the study areas may have been affected by sea water. Therefore, if the characteristics of these columnar joints are more intensively studied on a morphological, petrological, geochemical, and chronological level, we can better understand the developing mechanism of horizontal columnar joints.

  9. Impact of joint contractures on functioning and social participation in older individuals – development of a standard set (JointConFunctionSet): study protocol

    PubMed Central

    2013-01-01

    Background Joint contractures are frequent in older individuals in geriatric care settings. Even though they are used as indicator of quality of care, there is neither a common standard to describe functioning and disability in patients nor an established standardized assessment to describe and quantify the impact of joint contractures on patients’ functioning. Thus, the aim of our study is (1) to develop a standard set for the assessment of the impact of joint contractures on functioning and social participation in older individuals and (2) to develop and validate a standardized assessment instrument for describing and quantifying the impact of joint contractures on the individuals’ functioning. Methods The standard set for joint contractures integrate the perspectives of all potentially relevant user groups, from the affected individuals to clinicians and researchers. The development of this set follows the methodology to develop an International Classification of Functioning Disability and Health (ICF) Core Set and involves a formal decision-making and consensus process. Evidence from four preparatory studies will be integrated including qualitative interviews with patients, a systematic review of the literature, a survey with health professionals, and a cross sectional study with patients affected by joint contractures. The assessment instrument will be developed using item-response-theory models. The instrument will be validated. Discussion The standard set for joint contractures will provide a list of aspects of functioning and health most relevant for older individuals in geriatric care settings with joint contractures. This list will describe body functions, body structures, activities and participation and related environmental factors. This standard set will define what aspects of functioning should be assessed in individuals with joint contractures and will be the basis of the new assessment instrument to evaluate the impact of joint contractures on

  10. The development of goal-directed reaching in infants: hand trajectory formation and joint torque control.

    PubMed

    Konczak, J; Borutta, M; Topka, H; Dichgans, J

    1995-01-01

    Nine young infants were followed longitudinally from 4 to 15 months of age. We recorded early spontaneous movements and reaching movements to a stationary target. Time-position data of the hand (endpoint), shoulder, and elbow were collected using an optoelectronic measurement system (ELITE). We analyzed the endpoint kinematics and the intersegmental dynamics of the shoulder and elbow joint to investigate how changes in proximal torque control determined the development of hand trajectory formation. Two developmental phases of hand trajectory formation were identified: a first phase of rapid improvements between 16 and 24 weeks of age, the time of reaching onset for all infants. During that time period the number of movement units per reach and movement time decreased dramatically. In a second phase (28-64 weeks), a period of "fine-tuning" of the sensorimotor system, we saw slower, more gradual changes in the endpoint kinematics. The analysis of the underlying intersegmental joint torques revealed the following results: first, the range of muscular and motion-dependent torques (relative to body weight) did not change significantly with age. That is, early reaching was not confined by limitations in producing task-adequate levels of muscular torque. Second, improvements in the endpoint kinematics were not accomplished by minimizing amplitude of muscle and reactive torques. Third, the relative timing of muscular and motion-dependent torque peaks showed a systematic development toward an adult timing profile with increasing age. In conclusion, the development toward invariant characteristics of the hand trajectory is mirrored by concurrent changes in the control of joint forces. The acquisition of stable patterns of intersegmental coordination is not achieved by simply regulating force amplitude, but more so by modulating the correct timing of joint force production and by the system's use of reactive forces. Our findings support the view that development of reaching

  11. First Phase Development of Korea-Japan Joint VLBI Correlator and Its Current Progress

    NASA Technical Reports Server (NTRS)

    Oh, Se-Jin; Roh, Duk-Gyoo; Yeom, Jae-Hwan; Kobayashi, Hideyuki; Kawaguchi, Noriyuki

    2010-01-01

    The first phase of the Korea-Japan Joint VLBI Correlator (KJJVC) development has been completed and installed to correlate the observed data from KVN (Korean VLBI Network) and VERA (VLBI Exploration of Radio Astrometry) in October 2009. KJJVC is able to process 16 stations, a maximum of 8 Gbps/station, and 8,192 output channels for VLBI data. The system configuration, the experimental results, and future plans are introduced in this paper.

  12. Development of an Arthroscopic Joint Capsule Injury Model in the Canine Shoulder

    PubMed Central

    Kovacevic, David; Baker, Andrew R.; Staugaitis, Susan M.; Kim, Myung-Sun; Ricchetti, Eric T.; Derwin, Kathleen A.

    2016-01-01

    Background The natural history of rotator cuff tears can be unfavorable as patients develop fatty infiltration and muscle atrophy that is often associated with a loss of muscle strength and shoulder function. To facilitate study of possible biologic mechanisms involved in early degenerative changes to rotator cuff muscle and tendon tissues, the objective of this study was to develop a joint capsule injury model in the canine shoulder using arthroscopy. Methods Arthroscopic surgical methods for performing a posterior joint capsulectomy in the canine shoulder were first defined in cadavers. Subsequently, one canine subject underwent bilateral shoulder joint capsulectomy using arthroscopy, arthroscopic surveillance at 2, 4 and 8 weeks, and gross and histologic examination of the joint at 10 weeks. Results The canine subject was weight-bearing within eight hours after index and follow-up surgeries and had no significant soft tissue swelling of the shoulder girdle or gross lameness. Chronic synovitis and macroscopic and microscopic evidence of pathologic changes to the rotator cuff bony insertions, tendons, myotendinous junctions and muscles were observed. Conclusions This study demonstrates feasibility and proof-of-concept for a joint capsule injury model in the canine shoulder. Future work is needed to define the observed pathologic changes and their role in the progression of rotator cuff disease. Ultimately, better understanding of the biologic mechanisms of early progression of rotator cuff disease may lead to clinical interventions to halt or slow this process and avoid the more advanced and often irreversible conditions of large tendon tears with muscle fatty atrophy. PMID:26808837

  13. Alterations of the Temporomandibular Joint on Magnetic Resonance Imaging according to Growth and Development in Schoolchildren

    PubMed Central

    Tanaka, Tatsurou; Konoo, Tetsuro; Habu, Manabu; Oda, Masafumi; Kito, Shinji; Kodama, Masaaki; Kokuryo, Shinya; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Nishida, Ikuko; Morikawa, Kazumasa; Saeki, Katsura; Maki, Kenshi; Tominaga, Kazuhiro; Masumi, Shin-ichi; Terashita, Masamichi; Morimoto, Yasuhiro

    2012-01-01

    The paper explains the alterations of the temporomandibular joint (TMJ) visualized by magnetic resonance imaging (MRI) according to the growth and development of schoolchildren. Appearance and disappearance of a “double contour-like structure” (DCLS) of the mandibular condyle on MRI according to the growth and development of schoolchildren were demonstrated. In addition, possible constituents of DCLS and the significance of detection of DCLS on MRI were also speculated. The relationship between red marrow and yellow marrow in the articular eminence of temporal bone, the disappearance of DCLS, and alterations of the mandibular condyle have been elucidated. PMID:23316233

  14. Development of biomimetic quadruped walking robot with 2-DOF waist joint

    NASA Astrophysics Data System (ADS)

    Kim, Kyoung-Ho; Park, Se-Hoon; Lee, Yun-Jung

    2005-12-01

    This paper presented a novel bio-mimetic quadruped walking robot with 2-DOF (Degree Of Freedom) waist joint, which connects the front and the rear parts of the body. The waist-jointed walking robot can guarantee more stable and more animal-like gait than that of a conventional single-rigid-body walking robot. The developed robot, called ELIRO-II (Eating LIzard RObot version 2), can bend its body from side to side by using 1-DOF passive waist joint while the legs is transferred, thereby increasing the stride and speed of the robot. In addition, ELIRO-II has one more active DOF to bend its body up and down, which increases the mobility in irregular terrain such as slope and stairs. We design the mechanical structure of the robot, which is small and light to have high mobility. This research described characteristics of the 2-DOF waists joint and leg mechanism as well as a hardware and software of the controller of ELIRO-II.

  15. Development of the meniscus of the knee joint in human fetuses.

    PubMed

    Fukazawa, Ikuo; Hatta, Toshihisa; Uchio, Yuji; Otani, Hiroki

    2009-03-01

    Discoid meniscus of the knee joint occurs at a higher incidence in the lateral than in the medial menisci. Although its developmental origin has been suggested, it remains unclear. To verify the developmental etiology, we examined the meniscus of the knee joint in 41 human fetuses (from 14 to 30 weeks of gestation) and 14 adults (from 56 to 91 years of age) comparatively. The articular surfaces of the tibia and meniscus of the left knees in 40 fetuses and 14 adults were photographed and each area was measured by Scion Image (Scion; http://www.scioncorp.com). Morphometric analyses revealed that the proportion of the area of meniscus to that of the plateau was continuously higher in the lateral side than in the medial side. The right knee joints of seven fetuses were histologically observed, and the layered structure of fibers developed earlier in the lateral meniscus than in the medial in fetuses. The observed differential development of lateral and medial sides of the meniscus may be involved in the etiology of discoid meniscus. PMID:19243414

  16. [The development of a finger joint phantom for the optical simulation of early inflammatory rheumatic changes].

    PubMed

    Prapavat, V; Runge, W; Mans, J; Krause, A; Beuthan, J; Müller, G

    1997-11-01

    In the field of rheumatology, conventional diagnostic methods permit the detection only of advanced stages of the disease, which is at odds with the current clinical demand for the early diagnosis of inflammatory rheumatic diseases. Prompted by current needs, we developed a finger joint phantom that enables the optical and geometrical simulation of an early stage of rheumatoid arthritis (RA). The results presented here form the experimental basis for an evaluation of new RA diagnostic systems based on near infrared light. The early stage of RA is characterised mainly by a vigorous proliferation of the synovial membrane and clouding of the synovial fluid. Using a double-integrating-sphere technique, the absorption and scattering coefficients (mua, mus') are experimentally determined for healthy and pathologically altered synovial fluid and capsule tissue. Using a variable mixture of Intralipid Indian ink and water as a scattering/absorption medium, the optical properties of skin, synovial fluid or capsule can be selected individually. Since the optical and geometrical properties of bone tissue remain constant in early-stage RA, a solid material is used for its simulation. Using the finger joint phantom described herein, the optical properties of joint regions can be adjusted specifically, enabling an evaluation of their effects on an optical signal--for example, during fluorography--and the investigation of these effects for diagnostically useful information. The experimental foundation for the development of a new optical system for the early diagnosis of RA has now been laid. PMID:9490122

  17. [Experimental research of the influences on the development of the hip joints with excavated acetabula].

    PubMed

    Sun, D; Chen, X; Tang, C

    1996-12-01

    There are still arguments about the operation excavated acetabula treatments for the congenital dislocation of the hip. To inquire into the influences on the development of the hip joints with excavated acetabula size, we divided 60 two-month-old chickens into three groups which were given incised dislocation and then reduction partly excavated the cartilages of the acetabula and excavated them totally to the left hips respectively. Contrasting observation of all the experimental chickens was taken on the right ones of their own. The second group achieved a fair function of the joint movement. Limited and slight adhesion was not affecting the development of the joints seriously. The third group had, on the contrary, poor functions because of the comprehensive adhesion in the acetabula. The surfaces of the acetabula were replaced by fabric tissue. The remaining or regenerating cartilage cells vary obviously under the light scope and the electronic scope. The heads of the femurs had changed similarly. It is suggested that in dealing with the congenital dislocation of the hip, excavating the acetabola cartilage is not advisable. Partly excavating is permitted when a limited bony process existing in the bottom of the acetabula. PMID:9590781

  18. Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis

    PubMed Central

    Sagar, Devi Rani; Ashraf, Sadaf; Xu, Luting; Burston, James J; Menhinick, Matthew R; Poulter, Caroline L; Bennett, Andrew J; Walsh, David A; Chapman, Victoria

    2014-01-01

    Background Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). Objectives To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. Methods Male Sprague Dawley rats (140–260 g) were treated with either OPG-Fc (3 mg/kg, subcutaneously) or vehicle (phosphate-buffered saline) between days 1 and 27 (pre-emptive treatment) or days 21 and 27 (therapeutic treatment) after an intra-articular injection of MIA (1 mg/50 µl) or saline. A separate cohort of rats received the bisphosphonate zoledronate (100 µg/kg, subcutaneously) between days 1 and 25 post-MIA injection. Incapacitance testing and von Frey (1–15 g) hind paw withdrawal thresholds were used to assess pain behaviour. At the end of the study, rats were killed and the knee joints and spinal cord removed for analysis. Immunohistochemical studies using Iba-1 and GFAP quantified levels of activation of spinal microglia and astrocytes, respectively. Joint sections were stained with haematoxylin and eosin or Safranin-O fast green and scored for matrix proteoglycan and overall joint morphology. The numbers of tartrate-resistant acid phosphatase-positive osteoclasts were quantified. N=10 rats/group. Results Pre-emptive treatment with OPG-Fc significantly attenuated the development of MIA-induced changes in weightbearing, but not allodynia. OPG-Fc decreased osteoclast number, inhibited the formation of osteophytes and improved structural pathology within the joint similarly to the decrease seen after pretreatment with the bisphosphonate, zoledronate. Therapeutic treatment with OPG-Fc decreased pain behaviour, but did not improve pathology in rats with established joint damage. Conclusions Our data suggest that early targeting of osteoclasts may reduce pain associated with OA. PMID:23723320

  19. Development and laboratory testing of a 138-kV PPP-insulated joint for commercial application

    SciTech Connect

    Walldorf, S.P. ); Chu, H.; Elbadaly, H. )

    1990-04-01

    This paper describes the design, development and laboratory testing of a high voltage PPP (paper polypropylene/paper laminate) insulated joint for commercial application on 138-kV PPP-insulated cable. The design approach taken is conservative and addresses the typical variations in field conditions and in skill and workmanship of the splicing. Joint construction details, including choice of connector, taping structure, and joint mechanical reinforcement, are discussed. The test criteria are described and results are presented.

  20. Structural tests and development of a laminar flow control wing surface composite chordwise joint

    NASA Technical Reports Server (NTRS)

    Lineberger, L. B.

    1984-01-01

    The dramatic increases in fuel costs and the potential for periods of limited fuel availability provided the impetus to explore technologies to reduce transport aircraft fuel consumption. NASA sponsored the Aircraft Energy Efficiency (ACEE) program beginning in 1976 to develop technologies to improve fuel efficiency. The Lockheed-Georgia Company accomplished under NAS1-16235 Laminar-Flow-Control (LFC) Wing Panel Structural Design and Development (WSSD); design, manufacturing, and testing activities. An in-depth preliminary design of the baseline 1993 LFC wing was accomplished. A surface panel using the Lockheed graphite/epoxy integrated LFC wing box structural concept was designed. The concept was shown by analysis to be structurally efficient and cost effective. Critical details of the surface and surface joint was demonstrated by fabricating and testing complex, concept selection specimens. The Lockheed-Georgia Company accomplishments, Development of LFC Wind Surface Composite Structures (WSCS), are documented. Tests were conducted on two CV2 panels to verify the static tension and fatigue strength of LFC wing surface chordwise joints.

  1. The Role of Mother-Child Joint Play in the Early Development of Children's Conduct Problems: A Longitudinal Observational Study.

    ERIC Educational Resources Information Center

    Gardner, Frances; Ward, Sarah; Burton, Jennifer; Wilson, Charlotte

    2003-01-01

    Examined longitudinally the relationship between mother-child spontaneous joint play and development of conduct problems in 60 preschoolers. Found that amount of joint play at age 3 predicted individual improvement in conduct problems at age 4, and this association was independent of initial level of conduct problems and hyperactivity, social…

  2. Ground reaction forces and lower-limb joint kinetics of turning gait in typically developing children.

    PubMed

    Dixon, Philippe C; Stebbins, Julie; Theologis, Tim; Zavatsky, Amy B

    2014-11-28

    Turning is a common locomotor task essential to daily activity; however, very little is known about the forces and moments responsible for the kinematic adaptations occurring relative to straight-line gait in typically developing children. Thus, the aims of this study were to analyse ground reaction forces (GRFs), ground reaction free vertical torque (TZ), and the lower-limb joint kinetics of 90° outside (step) and inside (spin) limb turns. Step, spin, and straight walking trials from fifty-four typically developing children were analysed. All children were fit with the Plug-in Gait and Oxford Foot Model marker sets while walking over force plates embedded in the walkway. Net internal joint moments and power were computed via a standard inverse dynamics approach. All dependent variables were statistically analysed over the entire curves using the mean difference 95% bootstrap confidence band approach. GRFs were directed medially for step turns and laterally for spin turns during the turning phase. Directions were reversed and magnitudes decreased during the approach phase. Step turns showed reduced ankle power generation, while spin turns showed large TZ. Both strategies required large knee and hip coronal and transverse plane moments during swing. These kinetic differences highlight adaptations required to maintain stability and reorient the body towards the new walking direction during turning. From a clinical perspective, turning gait may better reveal weaknesses and motor control deficits than straight walking in pathological populations, such as children with cerebral palsy, and could potentially be implemented in standard gait analysis sessions. PMID:25311452

  3. Foundation-industry relationships--a new business model joint-venture philanthropy in therapy development.

    PubMed

    Bartek, Ronald J

    2014-01-01

    The business model for medical therapy development has changed drastically. Large companies that once conducted their own Research and Development (R&D) and funded all the preclinical studies, all phases of clinical development and marketing of the products are increasingly turning to others for more and more of the earlier work in hopes of being able to in-license a de-risked program well downstream, take it through the final phases of clinical development and into the marketplace. This new paradigm has required patient-advocacy foundations, especially in the rare-disease space, to become far more effective in building relationships with all the players along the therapy-development pathway -- academic scientists, government agencies, other foundations with overlapping interests, biotechs, small biopharmaceutical entities and even the larger industry companies. From the perspective of the patient-advocacy community, these increasingly essential public-private partnerships have taken on the nature of what could be called joint-venture philanthropy and involve a broad spectrum of collaborations and financial relationships between foundations and industry partners that are not without concerns about potential conflicts of interest. PMID:24283968

  4. Development of a complex parent-metabolite joint population pharmacokinetic model.

    PubMed

    Bertrand, Julie; Laffont, Céline M; Mentré, France; Chenel, Marylore; Comets, Emmanuelle

    2011-09-01

    This study aimed to develop a joint population pharmacokinetic model for an antipsychotic agent in development (S33138) and its active metabolite (S35424) produced by reversible metabolism. Because such a model leads to identifiability problems and numerical difficulties, the model building was performed using the FOCE-I and the Stochastic Approximation Expectation Maximization (SAEM) estimation algorithms in NONMEM and MONOLIX, respectively. Four different structural models were compared based on Bayesian information criteria. Models were first written as ordinary differential equations systems and then in closed form (CF) to facilitate further analyses. The impact of polymorphisms on genes coding for the CYP2C19 and CYP2D6 enzymes, respectively involved in the parent drug and the metabolite elimination were investigated using permutation Wald test. The parent drug and metabolite plasma concentrations of 101 patients were analyzed on two occasions after 4 and 8 weeks of treatment at 1, 3, 6, and 24 h following daily oral administration. All configurations led to a two compartment model with back-transformation of the metabolite into the parent drug and a first-pass effect. The elimination clearance of the metabolite through other processes than back-transformation was decreased by 35% [9-53%] in CYP2D6 poor metabolizer. Permutation tests were performed to ensure the robustness of the analysis, using SAEM and CF. In conclusion, we developed a complex joint pharmacokinetic model adequately predicting the impact of CYP2D6 polymorphisms on the parent drug and its metabolite concentrations through the back-transformation mechanism. PMID:21618059

  5. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin.

    PubMed

    Decker, Rebekah S; Koyama, Eiki; Enomoto-Iwamoto, Motomi; Maye, Peter; Rowe, David; Zhu, Shoutian; Schultz, Peter G; Pacifici, Maurizio

    2014-11-15

    Limb development requires the coordinated growth of several tissues and structures including long bones, joints and tendons, but the underlying mechanisms are not wholly clear. Recently, we identified a small drug-like molecule - we named Kartogenin (KGN) - that greatly stimulates chondrogenesis in marrow-derived mesenchymal stem cells (MSCs) and enhances cartilage repair in mouse osteoarthritis (OA) models. To determine whether limb developmental processes are regulated by KGN, we tested its activity on committed preskeletal mesenchymal cells from mouse embryo limb buds and whole limb explants. KGN did stimulate cartilage nodule formation and more strikingly, boosted digit cartilaginous anlaga elongation, synovial joint formation and interzone compaction, tendon maturation as monitored by ScxGFP, and interdigit invagination. To identify mechanisms, we carried out gene expression analyses and found that several genes, including those encoding key signaling proteins, were up-regulated by KGN. Amongst highly up-regulated genes were those encoding hedgehog and TGFβ superfamily members, particularly TFGβ1. The former response was verified by increases in Gli1-LacZ activity and Gli1 mRNA expression. Exogenous TGFβ1 stimulated cartilage nodule formation to levels similar to KGN, and KGN and TGFβ1 both greatly enhanced expression of lubricin/Prg4 in articular superficial zone cells. KGN also strongly increased the cellular levels of phospho-Smads that mediate canonical TGFβ and BMP signaling. Thus, limb development is potently and harmoniously stimulated by KGN. The growth effects of KGN appear to result from its ability to boost several key signaling pathways and in particular TGFβ signaling, working in addition to and/or in concert with the filamin A/CBFβ/RUNX1 pathway we identified previously to orchestrate overall limb development. KGN may thus represent a very powerful tool not only for OA therapy, but also limb regeneration and tissue repair strategies. PMID

  6. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin

    PubMed Central

    Decker, Rebekah S.; Koyama, Eiki; Enomoto-Iwamoto, Motomi; Maye, Peter; Rowe, David; Zhu, Shoutian; Schultz, Peter G.; Pacifici, Maurizio

    2014-01-01

    Limb development requires the coordinated growth of several tissues and structures including long bones, joints and tendons, but the underlying mechanisms are not wholly clear. Recently, we identified a small drug-like molecule -we named Kartogenin (KGN)- that greatly stimulates chondrogenesis in marrow-derived mesenchymal stem cells (MSCs) and enhances cartilage repair in mouse osteoarthritis (OA) models. To determine whether limb developmental processes are regulated by KGN, we tested its activity on committed preskeletal mesenchymal cells from mouse embryo limb buds and whole limb explants. KGN did stimulate cartilage nodule formation and more strikingly, boosted digit cartilaginous anlaga elongation, synovial joint formation and interzone compaction, tendon maturation as monitored by ScxGFP, and interdigit invagination. To identify mechanisms, we carried out gene expression analyses and found that several genes, including those encoding key signaling proteins, were up-regulated by KGN. Amongst highly up-regulated genes were those encoding hedgehog and TGFβ superfamily members, particularly TFGβ1. The former response was verified by increases in Gli1-LacZ activity and Gli1 mRNA expression. Exogenous TGFβ1 stimulated cartilage nodule formation to levels similar to KGN, and KGN and TGFβ1 both greatly enhanced expression of lubricin/Prg4 in articular superficial zone cells. KGN also strongly increased the cellular levels of phospho-Smads that mediate canonical TGFβ and BMP signaling. Thus, limb development is potently and harmoniously stimulated by KGN. The growth effects of KGN appear to result from its ability to boost several key signaling pathways and in particular TGFβ signaling, working in addition to and/or in concert with the filamin A/CBFβ/RUNX1 pathway we identified previously to orchestrate overall limb development. KGN may thus represent a very powerful tool not only for OA therapy, but also limb regeneration and tissue repair strategies. PMID

  7. The development of centres of ossification of bones forming elbow joints in young swine.

    PubMed Central

    Visco, D M; Hill, M A; Van Sickle, D C; Kincaid, S A

    1990-01-01

    Epiphyseal centres of ossification in the bones forming the elbow joints of pigs between one day and 15 weeks of age were examined radiographically, macroscopically, mesoscopically and microscopically. Thoracic limbs from 39 pigs were perfused with India ink or silicone rubber injection compound and the bones were dissected free of soft tissues. The humerus, ulna and radius were fixed in formalin or ethyl alcohol and then cleared by the modified Spalteholz technique. Bones were radiographed, examined grossly, and then cut into slabs for mesoscopical evaluation. Foci considered to be calcifying within cartilaginous anlage were selected for microscopical examination. It was concluded that the epiphyseal centre of ossification develops at different times in different sites in the bones forming the elbow joint. Centres of ossification are initiated when foci of chondrocytes adjacent to one side of a cartilage canal undergo hypertrophy and the inter-territorial matrix becomes calcified. Osteogenesis then proceeds in the calcified focus, presumably with osteoprogenitor cells that originate within the cartilage canals. Subsequently, each epiphyseal centre of ossification enlarges by one of two methods. Firstly, the layer of cartilage adjacent to the centre undergoes endochondral ossification, thus allowing for the circumferential growth of the epiphyseal centre of ossification. Secondly, foci of calcification develop adjacent to the ends of cartilage canals near the epiphyseal centre of ossification and eventually the focus of calcification coalesces with the developing epiphyseal centre of ossification, thus establishing a new ossification front. Endochondral ossification continues at the periphery of the mass of bone. Mesoscopical examination is more useful than radiographical evaluation for identifying small foci of calcification which precede epiphyseal centres of ossification. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 PMID:2081708

  8. Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

    PubMed Central

    KUMAGAI, KENICHI; SUZUKI, SATSUKI; KANRI, YORIAKI; MATSUBARA, RYOTA; FUJII, KEISUKE; WAKE, MASAHIRO; SUZUKI, RYUJI; HAMADA, YOSHIKI

    2015-01-01

    Temporomandibular joint (TMJ) osteoarthritis is typically a slowly progressive asymmetric disease. Little is known regarding the natural destruction of TMJ articular tissues. The aim of the present study was to investigate morphological changes in the TMJ of STR/ort mice, known to be the model for spontaneous osteoarthritis in the knee joint, and to evaluate STR/ort mice as a suitable animal model for TMJ osteoarthritis. TMJs from 32 STR/ort mice euthanized at 30, 40, 50 or 60 weeks of age, and from 6 CBA mice euthanized at 30, 40 or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using microcomputed tomography. At the age of 40–50 weeks, 17 (68%) of the 25 STR/ort mice had loss of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by microcomputed tomography. The STR/ort mouse strain appears to develop spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis. PMID:26171147

  9. Effects of Strength Training on Strength Development and Joint Position Sense in Functionally Unstable Ankles

    PubMed Central

    Docherty, Carrie L.; Moore, Josef H.; Arnold, Brent L.

    1998-01-01

    Objective: To examine the effects of ankle-strengthening exercises on joint position sense and strength development in subjects with functionally unstable ankles. Design and Setting: Subjects were randomly assigned to a training or control group. The training group participated in a 6-week strength-training protocol using rubber tubing 3 times a week throughout the training period. The control group did not participate in the strength-training protocol. Subjects: Twenty healthy college students (10 females, 10 males, age = 20.6 ± 2.23 years; ht = 176.40 ± 7.14 cm; wt = 74.18 ± 10.17 kg) with a history of functional ankle instability volunteered to participate in this study. Measurements: We pretested and posttested dorsiflexor and evertor isometric strength with a handheld dynamometer and collected joint position sense (JPS) data at 20° for inversion and plantar flexion and at 10° for eversion and dorsiflexion. Results: Statistical tests for strength and JPS revealed significant group-by-time interactions for dorsiflexion strength, eversion strength, inversion JPS, and plantar flexion JPS. Simple main-effects testing revealed improvements in training group strength and JPS at posttesting. There were no significant effects for eversion JPS, but the group main effect for dorsiflexion JPS was significant, with the experimental group having better scores than the control group. Conclusions: Ankle-strengthening exercises improved strength, inversion JPS, dorsiflexion JPS, and plantar flexion JPS in subjects with functionally unstable ankles. Imagesp311-a PMID:16558526

  10. Ukrainian Virtual Observatory: Current Status and Perspectives of Development of Joint Archives of Observations

    NASA Astrophysics Data System (ADS)

    Vavilova, I. B.; Pakuliak, L. K.; Protsyuk, Yu. I.; Virun, N. V.; Kashuba, S. G.; Pikhun, A. I.; Andrievsky, S. M.; Mazhaev, A. E.; Kazantseva, L. V.; Shlyapnikov, A. A.; Shulga, A. V.; Zolotukhina, A. V.; Sergeeva, T. P.; Miroshnichenko, A. P.; Andronov, I. L.; Breus, V. V; Virnina, N. A.

    2011-07-01

    The current state of the observational data archives of seven observatories of Ukraine which were created from 1898 to 2010 is considered in respect to their suitability for including into the Ukrainian Virtual Observatory (UkrVO) database. In accordance with a current UkrVO conception approved by the Ukrainian Astronomical Association, the database of astro negatives is the main scientific component of the UkrVO. The database will include all the photo plates accumulated in Ukraine and combine them into the Joint Digitized Archive (JDA). This will provide for a user an easy access to textual data and images using web interface and a corresponding search engine. The data archives obtained from CCD and radio observations in Ukraine are also discussed as scientific components of the UkrVO. Some prospects of the JDA development are formulated.

  11. Parental Support for Language Development During Joint Book Reading for Young Children With Hearing Loss

    PubMed Central

    DesJardin, Jean L.; Doll, Emily R.; Stika, Carren J.; Eisenberg, Laurie S.; Johnson, Karen J.; Ganguly, Dianne Hammes; Colson, Bethany G.; Henning, Shirley C.

    2014-01-01

    Parent and child joint book reading (JBR) characteristics and parent facilitative language techniques (FLTs) were investigated in two groups of parents and their young children; children with normal hearing (NH; n = 60) and children with hearing loss (HL; n = 45). Parent–child dyads were videotaped during JBR interactions, and parent and child behaviors were coded for specific JBR behaviors using a scale developed for this study. Children’s oral language skills were assessed using the Preschool Language Scale–4 (PLS-4). Parents of children with HL scored higher on two of the four subscales of JBR: Literacy Strategies and Teacher Techniques. Parents of children with NH utilized higher level FLTs with their children who had higher language skills. Higher level FLTs were positively related to children’s oral language abilities. Implications are discussed for professionals who work with families of very young children with HL. PMID:25309136

  12. Development of a rotary joint fluid coupling for Space Station Freedom

    NASA Technical Reports Server (NTRS)

    Costulis, John A.

    1991-01-01

    The design and development is described of a rotary joint fluid coupling for Space Station Freedom. The function of this fluid coupling is to transfer a heat rejection fluid between stationary and rotating interfaces with the Space Station thermal bus system. The design of this coupling incorporates a modular type design to allow maximum flexibility, two types of seals (mechanical face seals and shaft lip seals) for redundancy, materials with excellent ammonia compatibility, and coatings that enhance seal wear resistance and increased protection against corrosion. This design was thoroughly tested and met all design requirements. Potential applications of this hardware include uses in gun turrets, coal slurries, farming equipment, and any other applications that require the low leakage transfer of fluids between stationary and rotating interfaces.

  13. Development of a truss joint for robotic assembly of space structures

    NASA Technical Reports Server (NTRS)

    Parma, George F.

    1992-01-01

    This report presents the results of a detailed study of mechanical fasteners which were designed to facilitate robotic assembly of structures. Design requirements for robotic structural assembly were developed, taking into account structural properties and overall system design, and four candidate fasteners were designed to meet them. These fasteners were built and evaluated in the laboratory, and the Hammer-Head joint was chosen as superior overall. It had a high reliability of fastening under misalignments of 2.54 mm (0.1 in) and 3 deg, the highest end fixity (2.18), the simplest end effector, an integral capture guide, good visual verification, and the lightest weight (782 g, 1.72 lb). The study found that a good design should incorporate chamfers sliding on chamfers, cylinders sliding on chamfers, and hard surface finishes on sliding surfaces. The study also comments on robot flexibility, sag, hysteresis, thermal expansion, and friction which were observed during the testing.

  14. Rating Parent-Child Interactions: Joint Engagement, Communication Dynamics, and Shared Topics in Autism, Down Syndrome, and Typical Development

    PubMed Central

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke

    2012-01-01

    A battery of 17 rating items were applied to video records of typically-developing toddlers and young children with autism and Down syndrome interacting with their parents during the Communication Play Protocol. This battery provided a reliable and broad view of the joint engagement triad of child, partner, and shared topic. Ratings of the child’s joint engagement correlated very strongly with state coding of joint engagement and replicated the findings that coordinated joint engagement was less likely in children with autism and symbol-infused joint engagement was less likely in children with Down syndrome. Ratings of other child actions, of parent contributions, and of shared topics and communicative dynamics also documented pervasive variations related to diagnosis, language facility, and communicative context. PMID:22466689

  15. Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

    PubMed Central

    Rockel, Jason S.; Yu, Chunying; Whetstone, Heather; Craft, April M.; Reilly, Katherine; Ma, Henry; Tsushima, Hidetoshi; Puviindran, Vijitha; Al-Jazrawe, Mushriq; Keller, Gordon M.; Alman, Benjamin A.

    2016-01-01

    Both the WNT/β-catenin and hedgehog signaling pathways are important in the regulation of limb development, chondrocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA). It is not clear how these signaling pathways interact in interzone cell differentiation and synovial joint morphogenesis. Here, we determined that constitutive activation of hedgehog signaling specifically within interzone cells induces joint morphological changes by selectively inhibiting β-catenin–induced Fgf18 expression. Stabilization of β-catenin or treatment with FGF18 rescued hedgehog-induced phenotypes. Hedgehog signaling induced expression of a dominant negative isoform of TCF7L2 (dnTCF7L2) in interzone progeny, which may account for the selective regulation of β-catenin target genes observed. Knockdown of TCF7L2 isoforms in mouse chondrocytes rescued hedgehog signaling–induced Fgf18 downregulation, while overexpression of the human dnTCF7L2 orthologue (dnTCF4) in human chondrocytes promoted the expression of catabolic enzymes associated with OA. Similarly, expression of dnTCF4 in human chondrocytes positively correlated with the aggrecanase ADAMTS4. Consistent with our developmental findings, activation of β-catenin also attenuated hedgehog-induced or surgically induced articular cartilage degeneration in mouse models of OA. Thus, our results demonstrate that hedgehog inhibits selective β-catenin target gene expression to direct interzone progeny fates and articular cartilage development and disease. Moreover, agents that increase β-catenin activity have the potential to therapeutically attenuate articular cartilage degeneration as part of OA. PMID:27018594

  16. Development and application of biomimetic electrospun nanofibers in total joint replacement

    NASA Astrophysics Data System (ADS)

    Song, Wei

    Failure of osseointegration (direct anchorage of an implant by bone formation at the bone-implant surface) and implant infection (such as that caused by Staphylococcus aureus, S. aureus) are the two main causes of implant failure and loosening. There is a critical need for orthopedic implants that promote rapid osseointegration and prevent bacterial colonization, particularly when placed in bone compromised by disease or physiology of the patients. A better understanding of the key factors that influence cell fate decisions at the bone-implant interface is required. Our study is to develop a class of "bone-like" nanofibers (NFs) that promote osseointegration while preventing bacterial colonization and subsequent infections. This research goal is supported by our preliminary data on the preparation of coaxial electrospun NFs composed of polycaprolactone (PCL) and polyvinyl alcohol (PVA) polymers arranged in a core-sheath shape. The PCL/PVA NFs are biocompatible and biodegradable with appropriate fiber diameter, pore size and mechanical strength, leading to enhanced cell adhesion, proliferation and differentiation of osteoblast precursor cells. The objective is to develop functionalized "bone-like" PCL/PVA NFs matrix embedded with antibiotics (doxycycline (Doxy), bactericidal and anti-osteoclastic) on prosthesis surface. Through a rat tibia implantation model, the Doxy incorporated coaxial NFs has demonstrated excellent in promoting osseointegration and bacteria inhibitory efficacy. NFs coatings significantly enhanced the bonding between implant and bone remodeling within 8 weeks. The SA-induced osteomyelitis was prevented by the sustained release of Doxy from NFs. The capability of embedding numerous bio-components including proteins, growth factors, drugs, etc. enables NFs an effective solution to overcome the current challenged issue in Total joint replacement. In summary, we proposed PCL/PVA electrospun nanofibers as promising biomaterials that can be applied on

  17. Early Predictors of Communication Development in Young Children with Autism Spectrum Disorder: Joint Attention, Imitation, and Toy Play

    PubMed Central

    Munson, Jeffrey; Meltzoff, Andrew N.; Dawson, Geraldine

    2013-01-01

    This study investigated the unique contributions of joint attention, imitation, and toy play to language ability and rate of development of communication skills in young children with autism spectrum disorder (ASD). Sixty preschool-aged children with ASD were assessed using measures of joint attention, imitation, toy play, language, and communication ability. Two skills, initiating protodeclarative joint attention and immediate imitation, were most strongly associated with language ability at age 3–4 years, whereas toy play and deferred imitation were the best predictors of rate of communication development from age 4 to 6.5 years. The implications of these results for understanding the nature and course of language development in autism and for the development of targeted early interventions are discussed. PMID:16845578

  18. Effect of Metal Bond-Pad Configurations on the Solder Microstructure Development of Flip-Chip Solder Joints

    NASA Astrophysics Data System (ADS)

    Hu, Y. J.; Hsu, Y. C.; Huang, T. S.; Lu, C. T.; Wu, Albert T.; Liu, C. Y.

    2014-01-01

    Various microstructural zones were observed in the solidified solder of flip-chip solder joints with three metal bond-pad configurations (Cu/Sn/Cu, Ni/Sn/Cu, and Cu/Sn/Ni). The developed microstructures of the solidified flip-chip solder joints were strongly related to the associated metal bond pad. A hypoeutectic microstructure always developed near the Ni bond pad, and a eutectic or hypereutectic microstructure formed near the Cu pad. The effect of the metal bond pads on the solder microstructure alters the Cu solubility in the molten solder. The Cu content (solubility) in the molten Sn(Cu) solder eventually leads to the development of particular microstructures. In addition to the effect of the associated metal bond pads, the developed microstructure of the flip-chip solder joint depends on the configuration of the metal bond pads. A hypereutectic microstructure formed near the bottom Cu pad, and a eutectic microstructure formed near the top Cu pad. Directional cooling in the flip-chip solder joint during the solidification process causes the effects of the metal bond-pad configuration. Directional cooling causes the Cu content to vary in the liquid Sn(Cu) phase, resulting in the formation of distinct microstructural zones in the developed microstructure of the flip-chip solder joint.

  19. Baseline sacroiliac joint magnetic resonance imaging abnormalities and male sex predict the development of radiographic sacroiliitis.

    PubMed

    Akar, Servet; Isik, Sibel; Birlik, Bilge; Solmaz, Dilek; Sari, Ismail; Onen, Fatos; Akkoc, Nurullah

    2013-10-01

    We evaluated the relationship between the baseline sacroiliac joint (SIJ) magnetic resonance imaging (MRI) findings and the development of radiographic sacroiliitis and tested their prognostic significance in cases of ankylosing spondylitis. Patients who had undergone an SIJ MRI at the rheumatology department were identified. Individuals for whom pelvic X-rays were available after at least 1 year of MRI were included in the analysis. All radiographs and MRI examinations were scored by two independent readers. Medical records of the patients were reviewed to obtain potentially relevant demographic and clinical data. We identified 1,069 SIJ MRIs, and 328 fulfilled our inclusion criteria. Reliability analysis revealed moderate to good inter- and intra-observer agreement. On presentation data, 14 cases were excluded because they had unequivocal radiographic sacroiliitis at baseline. After a mean of 34.8 months of follow-up, 24 patients developed radiographic sacroiliitis. The presence of active sacroiliitis (odds ratio (OR) 15.1) and structural lesions on MRI (OR 8.3), male sex (OR 4.7), fulfillment of Calin's inflammatory back pain criteria (P = 0.001), and total MRI activity score (P < 0.001) were found to be related to the development of radiographic sacroiliitis. By regression modeling, the presence of both active inflammatory and structural damage lesions on MRI and male sex were found to be predictive factors for the development of radiographic sacroiliitis. Our present results suggest that the occurrence of both active inflammatory and structural lesions in SIJs revealed by MRI is a significant risk factor for radiographic sacroiliitis, especially in male patients with early inflammatory back pain. PMID:23765093

  20. Operational space weather product development and validation at the joint SMC-AFRL Rapid Prototyping Center

    NASA Astrophysics Data System (ADS)

    Quigley, S.

    The Air Force Research Laboratory (AFRL/VSB) and Detachment 11, Space &Missile Systems Center (SMC, Det 11/CIT) have combined efforts to design, develop, test, and implement graphical products for the Air Force's space weather operations center. These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense systems and communications. Jointly-developed products that have been, or will soon be added to real-time operations include: 1) the Operational Space Environment Network Display (OpSEND) suit - a set of four products that address HF communication, UHF satellite communication scintillation, radar auroral clutter, and GP S single- frequency errors; 2) a solar radio background and burst effects (SoRBE) product suite; and C) a meteor effects (ME) product suite. The RPC is also involved in a rather substantial "V&V" effort to produce multiple operational product verifications and validations, with an added end goal of a generalized validation software package. The presentation will provide a general overview of the RPC and each of the products mentioned above, to include background science, operational history, inputs, outputs, dissemination, and customer uses for each.

  1. Ruminant methane reduction through livestock development in Tanzania. Final report for US Department of Energy and US Initiative on Joint Implementation--Activities Implemented Jointly

    SciTech Connect

    Livingston, Roderick

    1999-07-01

    This project was designed to help develop the US Initiative on Joint Implementation activities in Eastern Africa. It has been communicated in meetings with representatives from the Ministry of Environment of Tanzania and the consultant group that developed Tanzania's National Climate Change Action Plan, the Centre for Energy, Environment, Science and Technology, that this project fits very well with the developmental and environmental goals of the Government of Tanzania. The goal of the Activities Implemented Jointly ruminant livestock project is to reduce ruminant methane emissions in Eastern Africa. The project plans a sustainable cattle multiplication unit (CMU) at Mabuki Ranch in the Mwanza Region of Tanzania. This CMU will focus on raising genetically improved animals to be purchased by farmers, developmental organizations, and other CMUs in Tanzania. Through the purchase of these animals farmers will raise their income generation potential and reduce ruminant methane emissions.

  2. JOINT-INDUSTRY PARTNERSHIP TO DEVELOP A HOLLOW SPHERE DUAL-GRADIENT DRILLING SYSTEM

    SciTech Connect

    William C. Maurer; Colin Ruan; Greg Deskins

    2003-05-01

    Maurer Technology Inc. (MTI) formed a joint-industry partnership to fund the development of a hollow sphere dual-gradient drilling (DGD) system. Phase I consisted of collecting, compiling, analyzing, and distributing information and data regarding a new DGD system for use by the oil and gas industry. Near the end of Phase I, DOE provided funding to the project that was used to conduct a series of critical follow-on tests investigating sphere separation in weighted waterbase and oilbase muds. Drilling costs in deep water are high because seawater pressure on the ocean floor creates a situation where many strings of casing are required due to the relatively close spacing between fracture and pore pressure curves. Approximately $100 million have been spent during the past five years on DGD systems that place pumps on the seafloor to reduce these drilling problems by reducing the annulus fluid pressure at the bottom of the riser. BP estimates that a DGD system can save $9 million per well in the Thunderhorse Field and Conoco estimates it can save $5 to $15 million per well in its deepwater operations. Unfortunately, previous DGD development projects have been unsuccessful due to the high costs ($20 to $50 million) and reliability problems with seafloor pump systems. MTI has been developing a simple DGD system concept that would pump hollow glass spheres into the bottom of the riser to reduce density of the mud in the riser. This eliminates the requirement for seafloor pumps and replaces them with low cost mud pumps, shale shakers, and other oilfield equipment that can be operated on the rig by conventional crews. A $1.8 million Phase I joint-industry project funded by five service companies and three operators showed that hollow spheres could be pumped well, but difficulties were encountered in separating the spheres from a polymer mud supplied by Halliburton due to the high viscosity of this mud at the low shear rates encountered on oilfield shale shaker screens. As a

  3. Skeletal development of hallucal tarsometatarsal joint curvature and angulation in extant apes and modern humans.

    PubMed

    Gill, Corey M; Bredella, Miriam A; DeSilva, Jeremy M

    2015-11-01

    The medial cuneiform, namely the curvature and angulation of its distal facet with metatarsal 1, is crucial as a stabilizer in bipedal locomotion and an axis upon which the great toe medially deviates during arboreal locomotion in extant apes. Previous work has shown that facet curvature and angulation in adult dry-bone specimens can distinguish African apes from Homo, and can even distinguish among species of Gorilla. This study provides the first ontogenetic assessment of medial cuneiform curvature and angulation in juvenile (n = 68) and adult specimens (n = 102) using computed tomography in humans and extant ape specimens, including Pongo. Our data find that modern human juveniles initially have a convex and slightly medially oriented osseous surface of the developing medial cuneiform distal facet that flattens and becomes more distally oriented with age. The same pattern (though of a different magnitude) occurs developmentally in the chimpanzee medial cuneiform, but not in Gorilla or Pongo, whose medial cuneiform facet angulation remains unchanged ontogenetically. These data suggest that the medial cuneiform ossifies in a distinguishable pattern between Pongo, Gorilla, Pan, and Homo, which may in part be due to subtle differences in the loading environment at the hallucal tarsometatarsal joint-a finding that has important implications for interpreting fossil medial cuneiforms. PMID:26319411

  4. Decorin Binding Proteins of Borrelia burgdorferi Promote Arthritis Development and Joint Specific Post-Treatment DNA Persistence in Mice

    PubMed Central

    Salo, Jemiina; Jaatinen, Annukka; Söderström, Mirva; Viljanen, Matti K.; Hytönen, Jukka

    2015-01-01

    Decorin binding proteins A and B (DbpA and B) of Borrelia burgdorferi are of critical importance for the virulence of the spirochete. The objective of the present study was to further clarify the contribution of DbpA and B to development of arthritis and persistence of B. burgdorferi after antibiotic treatment in a murine model of Lyme borreliosis. With that goal, mice were infected with B. burgdorferi strains expressing either DbpA or DbpB, or both DbpA and B, or with a strain lacking the adhesins. Arthritis development was monitored up to 15 weeks after infection, and bacterial persistence was studied after ceftriaxone and immunosuppressive treatments. Mice infected with the B. burgdorferi strain expressing both DbpA and B developed an early and prominent joint swelling. In contrast, while strains that expressed DbpA or B alone, or the strain that was DbpA and B deficient, were able to colonize mouse joints, they caused only negligible joint manifestations. Ceftriaxone treatment at two or six weeks of infection totally abolished joint swelling, and all ceftriaxone treated mice were B. burgdorferi culture negative. Antibiotic treated mice, which were immunosuppressed by anti-TNF-alpha, remained culture negative. Importantly, among ceftriaxone treated mice, B. burgdorferi DNA was detected by PCR uniformly in joint samples of mice infected with DbpA and B expressing bacteria, while this was not observed in mice infected with the DbpA and B deficient strain. In conclusion, these results show that both DbpA and B adhesins are crucial for early and prominent arthritis development in mice. Also, post-treatment borrelial DNA persistence appears to be dependent on the expression of DbpA and B on B. burgdorferi surface. Results of the immunosuppression studies suggest that the persisting material in the joints of antibiotic treated mice is DNA or DNA containing remnants rather than live bacteria. PMID:25816291

  5. Joint Attention in Parent-Child Dyads Involving Children with Selective Mutism: A Comparison between Anxious and Typically Developing Children

    ERIC Educational Resources Information Center

    Nowakowski, Matilda E.; Tasker, Susan L.; Cunningham, Charles E.; McHolm, Angela E.; Edison, Shannon; St. Pierre, Jeff; Boyle, Michael H.; Schmidt, Louis A.

    2011-01-01

    Although joint attention processes are known to play an important role in adaptive social behavior in typical development, we know little about these processes in clinical child populations. We compared early school age children with selective mutism (SM; n = 19) versus mixed anxiety (MA; n = 18) and community controls (CC; n = 26) on joint…

  6. 77 FR 38088 - Development of the Joint Strategic Plan on Intellectual Property Enforcement; Request of the U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ....S. market, protecting the intellectual property rights of U.S. rights holders, and protecting the... BUDGET Development of the Joint Strategic Plan on Intellectual Property Enforcement; Request of the U.S. Intellectual Property Enforcement Coordinator for Public Comments AGENCY: Office of the U.S....

  7. Rating Parent-Child Interactions: Joint Engagement, Communication Dynamics, and Shared Topics in Autism, Down Syndrome, and Typical Development

    ERIC Educational Resources Information Center

    Adamson, Lauren B.; Bakeman, Roger; Deckner, Deborah F.; Nelson, P. Brooke

    2012-01-01

    A battery of 17 rating items were applied to video records of typically-developing toddlers and young children with autism and Down syndrome interacting with their parents during the Communication Play Protocol. This battery provided a reliable and broad view of the joint engagement triad of child, partner, and shared topic. Ratings of the child's…

  8. Development and Applications of a Self-Contained, Non-Invasive EVA Joint Angle and Muscle Fatigue Sensor System

    NASA Technical Reports Server (NTRS)

    Ranniger, C. U.; Sorenson, E. A.; Akin, D. L.

    1995-01-01

    The University of Maryland Space Systems Laboratory, as a participant in NASA's INSTEP program, is developing a non-invasive, self-contained sensor system which can provide quantitative measurements of joint angles and muscle fatigue in the hand and forearm. The goal of this project is to develop a system with which hand/forearm motion and fatigue metrics can be determined in various terrestrial and zero-G work environments. A preliminary study of the prototype sensor systems and data reduction techniques for the fatigue measurement system are presented. The sensor systems evaluated include fiberoptics, used to measure joint angle, surface electrodes, which measure the electrical signals created in muscle as it contracts; microphones, which measure the noise made by contracting muscle; and accelerometers, which measure the lateral muscle acceleration during contraction. The prototype sensor systems were used to monitor joint motion of the metacarpophalangeal joint and muscle fatigue in flexor digitorum superficialis and flexor carpi ulnaris in subjects performing gripping tasks. Subjects were asked to sustain a 60-second constant-contraction (isometric) exercise and subsequently to perform a repetitive handgripping task to failure. Comparison of the electrical and mechanical signals of the muscles during the different tasks will be used to evaluate the applicability of muscle signal measurement techniques developed for isometric contraction tasks to fatigue prediction in quasi-dynamic exercises. Potential data reduction schemes are presented.

  9. Deliberate Play and Preparation Jointly Benefit Motor and Cognitive Development: Mediated and Moderated Effects.

    PubMed

    Pesce, Caterina; Masci, Ilaria; Marchetti, Rosalba; Vazou, Spyridoula; Sääkslahti, Arja; Tomporowski, Phillip D

    2016-01-01

    In light of the interrelation between motor and cognitive development and the predictive value of the former for the latter, the secular decline observed in motor coordination ability as early as preschool urges identification of interventions that may jointly impact motor and cognitive efficiency. The aim of this study was twofold. It (1) explored the outcomes of enriched physical education (PE), centered on deliberate play and cognitively challenging variability of practice, on motor coordination and cognitive processing; (2) examined whether motor coordination outcomes mediate intervention effects on children's cognition, while controlling for moderation by lifestyle factors as outdoor play habits and weight status. Four hundred and sixty children aged 5-10 years participated in a 6-month group randomized intervention in PE, with or without playful coordinative and cognitive enrichment. The weight status and spontaneous outdoor play habits of children (parental report of outdoor play) were evaluated at baseline. Before and after the intervention, motor developmental level (Movement Assessment Battery for Children) was evaluated in all children, who were then assessed either with a test of working memory (Random Number Generation task), or with a test of attention (from the Cognitive Assessment System). Children assigned to the 'enriched' intervention showed more pronounced improvements in all motor coordination assessments (manual dexterity, ball skills, static/dynamic balance). The beneficial effect on ball skills was amplified by the level of spontaneous outdoor play and weight status. Among indices of executive function and attention, only that of inhibition showed a differential effect of intervention type. Moderated mediation showed that the better outcome of the enriched PE on ball skills mediated the better inhibition outcome, but only when the enrichment intervention was paralleled by a medium-to-high level of outdoor play. Results suggest that

  10. Deliberate Play and Preparation Jointly Benefit Motor and Cognitive Development: Mediated and Moderated Effects

    PubMed Central

    Pesce, Caterina; Masci, Ilaria; Marchetti, Rosalba; Vazou, Spyridoula; Sääkslahti, Arja; Tomporowski, Phillip D.

    2016-01-01

    In light of the interrelation between motor and cognitive development and the predictive value of the former for the latter, the secular decline observed in motor coordination ability as early as preschool urges identification of interventions that may jointly impact motor and cognitive efficiency. The aim of this study was twofold. It (1) explored the outcomes of enriched physical education (PE), centered on deliberate play and cognitively challenging variability of practice, on motor coordination and cognitive processing; (2) examined whether motor coordination outcomes mediate intervention effects on children’s cognition, while controlling for moderation by lifestyle factors as outdoor play habits and weight status. Four hundred and sixty children aged 5–10 years participated in a 6-month group randomized intervention in PE, with or without playful coordinative and cognitive enrichment. The weight status and spontaneous outdoor play habits of children (parental report of outdoor play) were evaluated at baseline. Before and after the intervention, motor developmental level (Movement Assessment Battery for Children) was evaluated in all children, who were then assessed either with a test of working memory (Random Number Generation task), or with a test of attention (from the Cognitive Assessment System). Children assigned to the ‘enriched’ intervention showed more pronounced improvements in all motor coordination assessments (manual dexterity, ball skills, static/dynamic balance). The beneficial effect on ball skills was amplified by the level of spontaneous outdoor play and weight status. Among indices of executive function and attention, only that of inhibition showed a differential effect of intervention type. Moderated mediation showed that the better outcome of the enriched PE on ball skills mediated the better inhibition outcome, but only when the enrichment intervention was paralleled by a medium-to-high level of outdoor play. Results suggest that

  11. The early development of joint attention in infants with autistic disorder using home video observations and parental interview.

    PubMed

    Clifford, Sally M; Dissanayake, Cheryl

    2008-05-01

    The aim in the current study was to investigate the early development of joint attention, eye contact and affect during the first 2 years of life, by using retrospective parental interviews and analyses of home videos of infants who were later diagnosed with Autistic Disorder (AD). The 36 children with AD and the 27 matched control children were all aged between 3 and 5 years at recruitment. Reported anomalies in gaze and affect emerged in the children with AD as early as the first 6 months of life, generally becoming more severe just prior to the second birthday. Video data confirmed these anomalies from as early as the first year. Joint attention impairments were found throughout the second year of life. The results suggest that early dyadic behaviours-eye contact and affect-may play a role in the joint attention impairment in AD. PMID:17917803

  12. Development of brazing process for W-EUROFER joints using Cu-based fillers

    NASA Astrophysics Data System (ADS)

    de Prado, J.; Sánchez, M.; Ureña, A.

    2016-02-01

    A successful joint between W and EUROFER using high temperature brazing technique has been achieved for structural application in future fusion power plants. Cu-based powder alloy mixed with a polymeric binder has been used as filler. Microstructural analysis of the joints revealed that the joint consisted mainly of primary phases and acicular structures in a Cu matrix. Interaction between EUROFER and filler took place at the interface giving rise to several Cu-Ti-Fe rich layers. A loss of hardness at the EUROFER substrate close to the joint due to a diffusion phenomenon during brazing cycle was measured; however, the joints had an adequate shear strength value.

  13. Observing the development of the temporomandibular joint in embryonic and post-natal mice using various staining methods

    PubMed Central

    LIANG, WENNA; LI, XIHAI; GAO, BIZHEN; GAN, HUIJUAN; LIN, XUEJUAN; LIAO, LINGHONG; LI, CANDONG

    2016-01-01

    The temporomandibular joint (TMJ) is a specialized synovial joint that is essential for the movement and function of the mammalian jaw. The TMJ develops from two mesenchymal condensations, and is composed of the glenoid fossa that originates from the otic capsule by intramembranous ossification, the mandibular condyle of the temporal bone and a fibrocartilagenous articular disc derived from a secondary cartilaginous joint by endochondral ossification. However, the development of the TMJ remains unclear. In the present study, the formation and development of the mouse TMJ was investigated between embryonic day 13.5 and post-natal day 180 in order to elucidate the morphological and molecular alterations that occur during this period. TMJ formation appeared to proceed in three stages: Initiation or blastema stage; growth and cavitation stage; and the maturation or completion stage. In order to investigate the activity of certain transcription factors on TMJ formation and development, the expression of extracellular matrix (ECM), sex determining region Y-box 9, runt-related transcription factor 2, Indian hedgehog homolog, Osterix, collagen I, collagen II, aggrecan, total matrix metalloproteinase (MMP), MMP-9 and MMP-13 were detected in the TMJ using in situ and/or immunohistochemistry. The results indicate that the transcription factors, ECM and MMP serve critical functions in the formation and development of the mouse TMJ. In summary, the development of the mouse TMJ was investigated, and the molecular regulation of mouse TMJ formation was partially characterized. The results of the present study may aid the systematic understanding of the physiological processes underlying TMJ formation and development in mice. PMID:26893634

  14. The bHLH-PAS Transcription Factor Dysfusion Regulates Tarsal Joint Formation in Response to Notch Activity during Drosophila Leg Development

    PubMed Central

    Córdoba, Sergio; Estella, Carlos

    2014-01-01

    A characteristic of all arthropods is the presence of flexible structures called joints that connect all leg segments. Drosophila legs include two types of joints: the proximal or “true” joints that are motile due to the presence of muscle attachment and the distal joints that lack musculature. These joints are not only morphologically, functionally and evolutionarily different, but also the morphogenetic program that forms them is distinct. Development of both proximal and distal joints requires Notch activity; however, it is still unknown how this pathway can control the development of such homologous although distinct structures. Here we show that the bHLH-PAS transcription factor encoded by the gene dysfusion (dys), is expressed and absolutely required for tarsal joint development while it is dispensable for proximal joints. In the presumptive tarsal joints, Dys regulates the expression of the pro-apoptotic genes reaper and head involution defective and the expression of the RhoGTPases modulators, RhoGEf2 and RhoGap71E, thus directing key morphogenetic events required for tarsal joint development. When ectopically expressed, dys is able to induce some aspects of the morphogenetic program necessary for distal joint development such as fold formation and programmed cell death. This novel Dys function depends on its obligated partner Tango to activate the transcription of target genes. We also identified a dedicated dys cis-regulatory module that regulates dys expression in the tarsal presumptive leg joints through direct Su(H) binding. All these data place dys as a key player downstream of Notch, directing distal versus proximal joint morphogenesis. PMID:25329825

  15. Effects of Professional Development Training on Joint Attention Engagement in Low-Quality Childcare Centers

    ERIC Educational Resources Information Center

    Cain, David W.; Rudd, Loretta C.; Saxon, Terrill F.

    2007-01-01

    This study carries forward the exploration of joint attention engagement in children from 18 to 24 months of age enrolled in "low-quality" childcare centers. Childcare providers and children were videotaped to capture social interactions in the classroom including duration and bids for joint attention. One-half of 48 childcare providers were…

  16. The Challenge of Limiting Greenhouse Gas Emissions Through Activities implemented Jointly in Developing Countries: A Brazilian Perspective

    SciTech Connect

    La Rovere, E.L.

    1998-11-01

    This paper addresses, from the Brazilian perspective, the main problems with Joint Implementation/Activities Implemented Jointly (JI/AIJ) between industrialized (Annex I) and developing (non-Annex I) countries, as defined by the United Nations Framework Convention on Climate Change (UNFCCC). Four possible GHG emissions abatement measures are presented for Brazil: forest protection, reforestation projects for carbon sequestration or charcoal manufacturing, use of ethanol produced from sugar cane as a car fuel, and electrical energy conservation through an increase in end-use efficiencies. These four case studies form the basis of a discussion regarding the validity of developing countries' concerns about JI/AIJ. Recommendations are offered for overcoming the present shortcomings of JI/AIJ in developing countries. The primary conclusion is that Annex I countries' funding of JI/AIJ projects in developing countries in return for GHG emissions credits is not the best means to implement the UNFCCC. However, JI/AIJ projects can be a productive means of preventing global climate change if combined with other measures, including GHG emissions reduction targets for all countries involved in JI/AIJ projects and limits on the percentage of industrialized countries' emissions reductions that can be met through projects in developing countries.

  17. New developments in osteoarthritis. Sex differences in magnetic resonance imaging-based biomarkers and in those of joint metabolism

    PubMed Central

    2010-01-01

    Sex differences in the prevalence, incidence, and severity of osteoarthritis (OA) have long been known. Some differences in the evaluation of this issue across studies may be related to differences in study design, sampling, study size, study populations, targeted joint sites, and definitions of OA. This report highlights recent studies of sex differences in individual joint components imaged by magnetic resonance imaging and in systemic biomarkers of joint metabolism. Particularly important are those studies that examine this issue in young unaffected adults and children before the development of disease. Despite some variation across studies, women appear for the most part to have a thinner and more reduced volume of cartilage in the knee than men, and this may occur from early childhood. It is not clear whether women have a more accelerated rate of cartilage volume loss than men. Few data exist on sex differences in systemic biomarkers of joint metabolism. In these studies, it is critically important to characterize the total body burden of OA and the presence of comorbid conditions likely to influence a given biomarker. Lastly, future research should dovetail studies of sex differences in imaging and biochemical biomarkers with genetics to maximize insight into the mechanisms behind observed sex differences. PMID:20701741

  18. Joint Alpharma-Beef Species Symposium: implications of beef heifer development systems and lifetime productivity.

    PubMed

    Endecott, R L; Funston, R N; Mulliniks, J T; Roberts, A J

    2013-03-01

    Research emphasis has been placed on heifer development strategies in recent years, comparing traditional, more intensive systems to more extensive systems using less feed and relying on compensatory gain to reach a target BW. Recent research has indicated that developing heifers to a lighter target BW at breeding (i.e., 50 to 57% of mature BW compared with 60 to 65% BW) reduced development costs and did not impair reproductive performance. Research published through the late 1980s demonstrated greater negative effects of limited postweaning growth on age at puberty and pregnancy rates whereas more recent studies demonstrate less of a negative impact of delayed puberty on pregnancy rate. A limitation of most research concerning influences of nutrition on heifer development and cow reproductive performance is little or limited consideration of long-term implications. Longevity has relatively low heritability; therefore, heifer development and other management strategies have a greater potential to impact cow retention. Establishing the impact of heifer development protocols on longevity is complex, requiring consideration of nutritional factors after the start of breeding and through subsequent calvings. Lower-input heifer development, where all heifers are managed together after the postweaning period, did not impair rebreeding, but continued subsequent restriction in the form of marginal winter supplementation resulted in decreased retention in the breeding herd. Therefore, the compensatory BW gain period for restricted-growth heifers may be important to longevity and lifetime productivity. Adequate growth and development to ensure minimal calving difficulty can be of critical importance for longevity; however, providing additional supplemental feed during postweaning development to accomplish this may be less efficient than later in development. Restricting gain during postweaning development by limiting DMI or developing heifers on dormant winter forage resulted

  19. DEVELOPMENT OF A BIOLOGICAL SIMULATION MONITOR FOR JOINT MUNICIPAL/INDUSTRIAL TREATMENT SYSTEMS

    EPA Science Inventory

    Evaluation of existent monitoring hardware for the ultimate purpose of detecting the industrial wastewater source causing chronic or acute inefficiency in the performance of a joint biological treatment facility. The approach represents the first phase of the ultimate purpose; th...

  20. Development of an Underactuated 2-DOF Wrist Joint using McKibben PAMs

    NASA Astrophysics Data System (ADS)

    Rajagopal, S. P.; Jain, S.; Ramasubramanian, S. N.; Johnson, B. V.; Dwivedy, S. K.

    2014-10-01

    In this work, model of an underactuated 2-DOF wrist joint with pneumatically actuated muscles is proposed. For the joint, McKibben-type artificial muscles are used in parallel configuration for the actuation. For each Degree of Freedom (DOF) one agonist-antagonist pair arrangement is usually used with a pulley mechanism. A mathematical model of wrist joint is derived using conventional forward kinematic analysis. The static model relating pressure in the muscle with the orientation of the wrist joint is obtained by combining the experimental data and mathematical model. Regulation of pressure can be achieved by pulse width modulation control of on/off solenoid valves. A set of free vibration experiments are done for the dynamic identification of the muscle characteristics.

  1. Implementation of cystic fibrosis services in developing countries: memorandum from a Joint WHO/ICF(M)A meeting.

    PubMed Central

    1997-01-01

    A Joint WHO/ICF(M)A meeting defined strategies for the implementation and development of cystic fibrosis (CF) services in countries where CF is thought to be more common than is appreciated by the medical profession or the public and where CF services are either non-existent or in the early stages of development. The following common problems in such countries were identified: underdiagnosis; reduced life expectancy (relative to developed countries) among those diagnosed; a clinical profile that may vary from the "classic" description; poor availability of necessary drugs; and a lack of CF services or basic research on the condition. The following recommendations were made concerning CF: neonatal screening projects should be set up to determine its incidence and identify affected infants; national and regional laboratories should be encouraged to identify the specific mutations responsible for the condition in their populations; centres for diagnosis and treatment should be developed, using a team approach; a national organization, involving families and friends of individuals with CF and other volunteers, should be established; a national registry should be set up; awareness about the condition should be improved and knowledge about it developed among medical professionals, public health authorities, and the general public; and increased collaboration between groups and organizations (including pharmaceutical companies) at the national, regional, and international levels should be developed in order to exchange information about and promote knowledge of CF, and to stimulate the development of CF services in developing countries. PMID:9141744

  2. Nuclear propulsion technology development - A joint NASA/Department of Energy project

    NASA Technical Reports Server (NTRS)

    Clark, John S.

    1992-01-01

    NASA-Lewis has undertaken the conceptual development of spacecraft nuclear propulsion systems with DOE support, in order to establish the bases for Space Exploration Initiative lunar and Mars missions. This conceptual evolution project encompasses nuclear thermal propulsion (NTP) and nuclear electric propulsion (NEP) systems. A technology base exists for NTP in the NERVA program files; more fundamental development efforts are entailed in the case of NEP, but this option is noted to offer greater advantages in the long term.

  3. Development of a cable reel development system using a rotary joint for kilometer lengths of two-fiber multi-mode fiber optic cable

    SciTech Connect

    Curtiss, J.A.; Jahelka, J.R.

    1995-08-11

    Brookhaven National Laboratory (BNL) recently developed a two-component system for use during remote inspections. The system consists of a mobile unit with television cameras and other equipment and a stationary base station. A variety of signals must be continually transmitted between the two system components as the mobile unit is moved from the location to another. Two channels of broadband (10MHz) NTSC video are transmitted from the mobile unit to the base station, and a bi-directional ``talk set`` provides audio communication between personnel at each location. In addition, several channels of RS-232 are required to support present and future instruments used at the mobile unit and controlled by personnel at the base station. Brookhaven developed a mobile unit which communicated with a base station over a 2-fiber multimode fiber optic cable. One of the design requirements was maintaining constant communication with the base station during the time the mobile unit was moved about. To provide uninterrupted communications, deployment of the 1-km long fiber optic cable was initially performed with a ``spinning reel`` mechanism. The spinning reel mechanism proved to be mechanically unsuitable, and so the cable deployment mechanism was redesigned to spool the cable off the reel. The requirement for uninterrupted communications required a two-channel fiber optic rotary joint in the design. Incorporation of the rotary joint into the design is described, and appropriate reference material is included.

  4. Jointing around magmatic dikes as a precursor to the development of volcanic plugs

    NASA Astrophysics Data System (ADS)

    Townsend, Meredith; Pollard, David D.; Johnson, Kendra; Culha, Cansu

    2015-10-01

    Basaltic volcanic eruptions typically initiate as fissures fed by dikes. In some cases, eruptions become localized through discrete vents, until the flow is sustained through a single vent underlain by a volcanic plug, at which point, the eruption is capable of delivering much greater volumes of magma to the surface. Existing theories to explain flow localization focus on the relationship between non-uniform dike thickness and variations in magma flow rates. Here, we propose a mechanism for conduit widening that precedes flow localization, and we present geologic evidence from an Oligocene-aged dike-plug system at Ship Rock, New Mexico. We use techniques of structure from motion to map 621 joints in the sedimentary rock adjacent to the intrusions and find that these joints are part of a systematic set oriented perpendicular to the dikes and localized to within a meter of the dike contacts. This joint set, along with a set of dike-parallel joints and the bedding planes, divides the strata into rectangular blocks that subsequently are entrained in the flowing magma to widen the dikes. Using field and lab data and a stress analysis, we show that the dike-perpendicular joints are intimately associated with the emplacement of magma and thermal pressurization of pore fluids in the host rock. This fracturing process is a precursor to entrainment of the host rock and sustained flow through discrete vents.

  5. Development of computerized materials, protection, control and accountability systems in the former Soviet republics: a joint effort

    SciTech Connect

    Whiteson, R.; Ryan, R.H.; Seitz, S.; Landry, R.P.

    1996-07-01

    The laboratory-to-laboratory programs of cooperation between the US Department of Energy (DOE) and the Institutes of the Russian Federation and the government-to-government programs between the US and Russia have the goal of reducing the danger of nuclear weapons proliferation by strengthening systems of nuclear materials protection, control, and accountability (MPC&A). As part of these programs, DOE is making available to sites in the former Soviet Republics a new-generation nuclear materials accountability system similar to one developed for DOE sites. This new system, the Core Materials Accountability System (COREMAS), is designed for international use. It is a core system to which facility-specific extensions are expected to be made. This paper describes the joint efforts of US personnel and software development teams at sites in Russia, Kazakhstan, and the Ukraine to develop sophisticated computerized MPC&A systems that are customized for the site-specific needs of each facility.

  6. Development and applications of a software tool for diarthrodial joint analysis.

    PubMed

    Martelli, Sandra; Lopomo, Nicola; Greggio, Samuele; Ferretti, Emil; Visani, Andrea

    2006-07-01

    This paper describes a new software environment for advanced analysis of diarthrodial joints. The new tool provides a number of elaboration functions to investigate the joint kinematics, bone anatomy, and ligament and tendon properties. In particular, the shapes and the contact points of the articulating surfaces can be displayed and analysed through 2D user-defined sections and fittings (lines or conics). Ligament behaviour can be evaluated during joint movement, through the computation of elongations, orientations, and fiber strain. Motion trajectories can be also analysed through the calculation of helical axes, instantaneous rotations, and displacements in specific user-chosen coordinate reference frames. The software has an user-friendly graphical interface to display four-dimensional data (time-space data) obtained from medical images, navigation systems, spatial linkages or digitalizers, and can also generate printable reports and multiple graphs as well as ASCII files that can be imported to spreadsheet programs such as Microsoft Excel. PMID:16777259

  7. [Development of a testing device for knee joint kinematics parameters of patients with strokes].

    PubMed

    Xu, Xiulin; Ji, Xuefei; Xu, Xijiao; Zhao, Hongyao

    2013-04-01

    This article is aimed to present a design of a testing device for knee joint kinematics parameters of patients with strokes. We used Auto CAD to design the knee joint sensor device, and applied multifunction data acquisition card to collect sensor data. Then we transferred the data to the computer to quantitatively detect and analyze the joint angle, angular velocity and other parameters. The software system used Visual C+ + MFC frame and shared database Access, and used ADO technology to realize the collection between the software system and patient information system. After a preliminary test of 20 healthy subjects, the result showed that intraclass correlation coefficient (ICC) was more than 0.8, indicating a good reliability of the instrument. PMID:23858756

  8. Note: Development of a compact electromagnetic hydraulic pump for a microrobot joint driving system.

    PubMed

    Chen, Naijian; Wang, Sun'an; Zhang, Jinhua

    2010-04-01

    This note describes a compact electromagnetic hydraulic pump (EMHP) designed primarily to build a microdriving system for a robot joint actuator. A characteristic mathematical model integrating electricity, magnetism, and hydraulics is constructed to represent the working process of the EMHP. Tests show that a volumetric flow rate of up to 430 cm(3)/min and load pressure of up to 2.5 MPa can be achieved. The prototype pump can supply stable pressure of 0-2.4 MPa and acceleration of 1.2 MPa/s for the robot joint actuator. PMID:20441378

  9. Diagnostic development for determining the joint temperature/soot statistics in hydrocarbon-fueled pool fires : LDRD final report.

    SciTech Connect

    Casteneda, Jaime N.; Frederickson, Kraig; Grasser, Thomas W.; Hewson, John C.; Kearney, Sean Patrick; Luketa, Anay Josephine

    2009-09-01

    A joint temperature/soot laser-based optical diagnostic was developed for the determination of the joint temperature/soot probability density function (PDF) for hydrocarbon-fueled meter-scale turbulent pool fires. This Laboratory Directed Research and Development (LDRD) effort was in support of the Advanced Simulation and Computing (ASC) program which seeks to produce computational models for the simulation of fire environments for risk assessment and analysis. The development of this laser-based optical diagnostic is motivated by the need for highly-resolved spatio-temporal information for which traditional diagnostic probes, such as thermocouples, are ill-suited. The in-flame gas temperature is determined from the shape of the nitrogen Coherent Anti-Stokes Raman Scattering (CARS) signature and the soot volume fraction is extracted from the intensity of the Laser-Induced Incandescence (LII) image of the CARS probed region. The current state of the diagnostic will be discussed including the uncertainty and physical limits of the measurements as well as the future applications of this probe.

  10. Design and development of high-temperature superconducting magnet system with joint-winding for the helical fusion reactor

    NASA Astrophysics Data System (ADS)

    Yanagi, N.; Ito, S.; Terazaki, Y.; Seino, Y.; Hamaguchi, S.; Tamura, H.; Miyazawa, J.; Mito, T.; Hashizume, H.; Sagara, A.

    2015-05-01

    An innovative winding method is developed by connecting high-temperature superconducting (HTS) conductors to enable efficient construction of a magnet system for the helical fusion reactor FFHR-d1. A large-current capacity HTS conductor, referred to as STARS, is being developed by the incorporation of several innovative ideas, such as the simple stacking of state-of-the-art yttrium barium copper oxide tapes embedded in a copper jacket, surrounded by electrical insulation inside a conductor, and an outer stainless-steel jacket cooled by helium gas. A prototype conductor sample was fabricated and reached a current of 100 kA at a bias magnetic field of 5.3 T with the temperature at 20 K. At 4.2 K, the maximum current reached was 120 kA, and a current of 100 kA was successfully sustained for 1 h. A low-resistance bridge-type mechanical lap joint was developed and a joint resistance of 2 nΩ was experimentally confirmed for the conductor sample.

  11. Development and Implementation of Joint Programs in Laser Ranging and Other Space Geodetic Techniques

    NASA Technical Reports Server (NTRS)

    Pearlman, Michael R.; Carter, David (Technical Monitor)

    2004-01-01

    This progress report discusses the status and progress made in joint international programs including: 1) WEGENER; 2) Arabian Peninsula program; 3) Asia-Pacific Space Geodynamics (APSG) program; 4) the Fourteenth International Workshop on Laser Ranging; 5) the International Laser Ranging Service; and 6) current support for the NASA network.

  12. Learning to Look for Language: Development of Joint Attention in Young Deaf Children

    ERIC Educational Resources Information Center

    Lieberman, Amy M.; Hatrak, Marla; Mayberry, Rachel I.

    2014-01-01

    Joint attention between hearing children and their caregivers is typically achieved when the adult provides spoken, auditory linguistic input that relates to the child's current visual focus of attention. Deaf children interacting through sign language must learn to continually switch visual attention between people and objects in order to…

  13. Parental Support for Language Development during Joint Book Reading for Young Children with Hearing Loss

    ERIC Educational Resources Information Center

    DesJardin, Jean L.; Doll, Emily R.; Stika, Carren J.; Eisenberg, Laurie S.; Johnson, Karen J.; Ganguly, Dianne Hammes; Colson, Bethany G.; Henning, Shirley C.

    2014-01-01

    Parent and child joint book reading (JBR) characteristics and parent facilitative language techniques (FLTs) were investigated in two groups of parents and their young children; children with normal hearing (NH; "n" = 60) and children with hearing loss (HL; "n" = 45). Parent-child dyads were videotaped during JBR interactions,…

  14. Preface: Joint Discussion JD5 From Meteors and Meteorites to their Parent Bodies: Current Status and Future Developments

    NASA Astrophysics Data System (ADS)

    Montmerle, Thierry

    2015-03-01

    The Joint Discussion 5 entitled "From Meteors and Meteorites to their Parent Bodies: Current Status and Future Developments" within the IAU GA 2012 was organized with the coordination of the IAU Division III Planetary Systems Sciences and the IAU Commission N. 22 Meteors, Meteorites & Interplanetary Dust, together with the supports by Divisions I Fundamental Astronomy, Division XII Union-Wide Activities, Commission 4 Ephemerides, Commission 6 Astronomical Telegrams, Commission 8 Astrometry, Commission 15 Physical Study of Comets & Minor Planets, and Commission 20 Positions & Motions of Minor Planets, Comets & Satellites.

  15. To the development of an automated system of assessment of radiological images of joints

    NASA Astrophysics Data System (ADS)

    Grechikhin, A. I.; Grunina, E. A.; Karetnikova, I. R.

    2008-03-01

    An algorithm developed for the adaptive automated computer processing of radiological images of hands and feet in order to assess the degree of bone and cartilage destruction in rheumatoid arthritis is described. A set of new numeral signs was proposed in order to assess a degree of arthritis radiological progression.

  16. Joint Development of Bullying and Victimization in Adolescence: Relations to Delinquency and Self-Harm

    ERIC Educational Resources Information Center

    Barker, Edward D.; Arseneault, Louise; Brendgen, Mara; Fontaine, Nathalie; Maughan, Barbara

    2008-01-01

    The study measures the development of bullying and victimization in early to mid-adolescence, the relations between the developmental trajectories, and their associations with delinquency and self-harm. Evidence suggests youths victimized by peers are at increased risk of victimizing others.

  17. Develop virtual joint laboratory for education like distance engineering system for robotic applications

    NASA Astrophysics Data System (ADS)

    Latinovic, T. S.; Deaconu, S. I.; Latinović, M. T.; Malešević, N.; Barz, C.

    2015-06-01

    This paper work with a new system that provides distance learning and online training engineers. The purpose of this paper is to develop and provide web-based system for the handling and control of remote devices via the Internet. Remote devices are currently the industry or mobile robots [13]. For future product development machine in the factory will be included in the system. This article also discusses the current use of virtual reality tools in the fields of science and engineering education. One programming tool in particular, virtual reality modeling language (VRML) is presented in the light of its applications and capabilities in the development of computer visualization tool for education. One contribution of this paper is to present the software tools and examples that can encourage educators to develop a virtual reality model to improve teaching in their discipline. [12] This paper aims to introduce a software platform, called VALIP where users can build, share, and manipulate 3D content in cooperation with the interaction processes in a 3D context, while participating hardware and software devices can be physical and / or logical distributed and connected together via the Internet. VALIP the integration of virtual laboratories to appropriate partners; therefore, allowing access to all laboratories in any of the partners in the project. VALIP provides advanced laboratory for training and research within robotics and production engineering, and thus, provides a great laboratory facilities with only having to invest a limited amount of resources at the local level to the partner site.

  18. In Support of Access and Inclusion: Joint Professional Development for Science and Special Educators

    ERIC Educational Resources Information Center

    Brusca-Vega, Rita; Alexander, Jan; Kamin, Colleen

    2014-01-01

    Collaborative professional development of science and special educators leads to improved access and inclusion of students with disabilities. Yet, despite poor science achievement of students with disabilities, their increasing presence in general education science classrooms, and research that demonstrates effective teaching strategies for…

  19. New approach to telemetry development will significantly increase productivity of Joint Test Assembly (JTA) teams

    NASA Astrophysics Data System (ADS)

    Gee, K. T.

    1987-10-01

    We design telemetry systems which instrument weapons in the Joint DoD/DOE flight test program. These telemetry systems gather data which can be used to determine if a weapon system functioned as intended. A reusable telemetry electronics system to support new programs for the next decade and to replace old telemetry systems which can no longer be produced is being designed. This multisystem Joint Test Assembly, named JTAX, is being designed to be modular, flexible, and testable. The requirements for each program can be met by choosing the necessary circuitry from a list of off-the-shelf, flexible electronics modules. Present day electronics miniaturization will allow these modules to consist of a few integrated circuits. System-specific circuits can be added to the architecture via well-defined interfaces. Off-the-shelf and system-specific circuitry are connected on printed circuit boards which are designed to meet the unique mechanical constraints for each system.

  20. Numerical Modeling of Ti Deformation for the Development of a Titanium and Stainless Steel Transition Joint

    NASA Astrophysics Data System (ADS)

    Mukherjee, A. B.; Kapoor, R.; Thota, M. K.; Chakravartty, J. K.

    2016-05-01

    Finite element analysis (FEA) was used to model the joining of titanium grade 2 (Ti) to AISI 321 stainless steel (SS) transition joint of lap configuration with grooves at the interface on SS side. The hot forming of Ti for filling the grooves without defects was simulated. FEA involving large plastic flow with sticking friction condition was initially validated using compression test on cylindrical specimen at 900 °C. The barreled shape and a no-deformation zone in the sample predicted by FEA matched with those of the compression experiments. For the joining process, FEA computed the distribution of strain and hydrostatic stress in Ti and the minimum ram load required for a defect-free joint. The hot forming parameters for Ti to fill the grooves without defects and any geometrical distortion of the die were found to be 0.001 s-1 at 900 °C. Using these conditions a defect-free Ti-SS joint was experimentally produced.

  1. Planning my actions to accommodate yours: joint action development during early childhood.

    PubMed

    Meyer, Marlene; van der Wel, Robrecht P R D; Hunnius, Sabine

    2016-05-01

    The planning and adjusting of one's actions in relation to an action partner is fundamental to smooth joint action. During their first years of life, children gradually become more engaged in joint actions. Here, we investigated whether and at what age children take their partner into account in their action plans to accommodate the other's actions. We focused on children's proactive planning (without prior experience) and flexible adjustment of action plans over time. In a behavioural study, we tested 96 children from four age groups (2½, 3, 3½ and 5 years) in a joint cup-stacking task. Children passed cups to their partner who had only one hand available (alternating over time) to build a tower. Children's response choices were assessed (i.e. passing the cup on the free or occupied side to their partner). The study yielded two major findings. At all ages, children proactively planned their actions in a way that accommodated their partner's actions. However, only by 3½ years did children start to flexibly integrate their partner into their action plans. Even at age 5, children only showed minimal adjustments to their action partner. Candidate processes underlying these developmental changes (e.g. inhibitory control, cognitive flexibility, perspective taking) are discussed. PMID:27069048

  2. Preliminary results on the development of vacuum-brazed joints for cyrogenic wind tunnel aerofoil models

    SciTech Connect

    Wigley, D.A.; Lawing, P.L.; Sandefur, P.G.

    1982-01-01

    Initial trials carried out at the NASA Langley Research Center in the investigation of cryogenic wind tunnel joint construction demonstrated that diffusion-assisted brazed joints could be formed in 17-4 PH, 15-5 PH, AISI-type 347, and Nitronic 40 stainless steels using electrodeposited copper as the bonding agent. Subsequent work has concentrated on 15-5 PH and Nitronic 40 using thin foils of pure copper and Nicrobraz LM, a commercially available nickel-based alloy containing boron and silicon melting point depressants. This paper summarizes the work carried out to understand and evaluate these bonds and their metallurgical characteristics. The results indicate that a high-strength void-free bond can be formed by the vacuum brazing of stainless steels using copper- and nickel-based filler alloys. The Nitronic 40 brazed joints show strengths in excess of the yield strengths of the parent metal. The poor toughness of 15-5 PH stainless steel at cryogenic temperatures tends to disqualify its use in critical areas of low-temperature aerofoil models.

  3. Numerical Modeling of Ti Deformation for the Development of a Titanium and Stainless Steel Transition Joint

    NASA Astrophysics Data System (ADS)

    Mukherjee, A. B.; Kapoor, R.; Thota, M. K.; Chakravartty, J. K.

    2016-07-01

    Finite element analysis (FEA) was used to model the joining of titanium grade 2 (Ti) to AISI 321 stainless steel (SS) transition joint of lap configuration with grooves at the interface on SS side. The hot forming of Ti for filling the grooves without defects was simulated. FEA involving large plastic flow with sticking friction condition was initially validated using compression test on cylindrical specimen at 900 °C. The barreled shape and a no-deformation zone in the sample predicted by FEA matched with those of the compression experiments. For the joining process, FEA computed the distribution of strain and hydrostatic stress in Ti and the minimum ram load required for a defect-free joint. The hot forming parameters for Ti to fill the grooves without defects and any geometrical distortion of the die were found to be 0.001 s-1 at 900 °C. Using these conditions a defect-free Ti-SS joint was experimentally produced.

  4. [Health promotion policy and urban planning: joint efforts for the development of healthy cities].

    PubMed

    Sperandio, Ana Maria Girotti; Francisco, Lauro Luiz; Mattos, Thiago Pedrosa

    2016-06-01

    The National Health Promotion Policy (PNPS) defines strategies for devising inter-sectoral public policies that ensure the development of healthy cities. Urban planning constitutes a tool to improve the quality of life and enhance health promotion. Using the studies and cooperation actions conducted by the Urban Research Laboratory (LABINUR/FEC-Unicamp) as a reference, this article describes relevant aspects of the PNPS that have an interface with urban planning policies in Brazil. An increase in interdisciplinary and inter-sectoral measures related to the new PNPS after the passing of Ordinance 2.446/14 was identified, which include: mobility and accessibility; safe development (sanitation, housing and transport); healthy eating with social inclusion and reduction of poverty (community vegetable gardens); corporal activities and physical exercise and the enhancement of urban spaces. The conclusion drawn is that social participation, inter-sectoral activities and the role of the university are important aspects for the promotion of healthy cities. PMID:27276542

  5. Does Improving Joint Attention in Low-Quality Child-Care Enhance Language Development?

    ERIC Educational Resources Information Center

    Rudd, Loretta C.; Cain, David W.; Saxon, Terrill F.

    2008-01-01

    This study examined effects of professional development for child-care staff on language acquisition of children ages 14-36 months. Child-care staff from 44 child-care centres agreed to participate in the study. Child-care staff from one-half of the child-care centres were randomly assigned to a one-time, four-hour workshop followed by three…

  6. The 1997 JANNAF Propellant Development and Characterization Subcommittee and Safety and Environmental Protection Subcommittee Joint Meeting

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Filliben, Jeff D. (Editor); Watson, Anne H. (Editor)

    1997-01-01

    In the Propellant Development and Characterization Subcommittee (PDCS) meeting, topics included: the analysis, characterization, and processing of propellants and propellant ingredients; chemical reactivity; liquid propellants; test methods; rheology; surveillance and aging; and process engineering. In the Safety and Environmental Protection Subcommittee (S&EPS) meeting, topics covered included: hydrazine propellant vapor detection methods; toxicity of propellants and propellants; explosives safety; atmospheric modeling and risk assessment of toxic releases; reclamation, disposal, and demilitarization methods; and remediation of explosives or propellant contaminated sites.

  7. Pre-Operative Status and Quality of Life Following Total Joint Replacement in a Developing Country: A Prospective Pilot Study

    PubMed Central

    Niu, Nina N.; Collins, Jamie E.; Thornhill, Thomas S.; Alcantara Abreu, Luis; Ghazinouri, Roya; Okike, Kanu; Katz, Jeffrey N.

    2011-01-01

    Background: An increasing number of medical relief organizations have launched programs to perform total joint replacements in the developing world. There is a paucity of data on the clinical outcomes of these procedures. We documented pre- and post-operative pain and functional status in a group of low income Dominicans who underwent total hip or knee replacement performed by an American relief organization. Methods: In March 2009 and 2010, we surveyed patients participating in Operation Walk Boston, a medical relief organization that provides total joint replacements to patients in the Dominican Republic. Questionnaires included the Western Ontario and McMaster University Osteoarthritis (WOMAC) Index scales and the Short-Form 36 (SF-36) scales for physical activity and mental health. Scores were transformed to a 0 - 100 point scale (100 is best). Results: 81 individuals (mean age 61 years, 60% female) completed the pre-operative questionnaires. Twenty eight of the 35 who completed preoperative forms in 2009 also completed follow up forms in 2010 (follow-up rate 80%). Patients reported poor pre-operative WOMAC function (mean = 33.6, sd = 22.0) and WOMAC pain (mean = 38.4, sd = 22.9) scores preoperatively. Mean post-operative WOMAC pain and function scores were 86.4 (sd = 13.1) and 88.1 (sd = 11.4) respectively. Improvement in pain and function was similar for patients undergoing hip (n=11) and knee (n=17) replacements. Conclusion: Total joint replacement was effective in relieving pain and restoring function in this program. These results are useful for comparison to outcomes in developed countries and for establishing benchmarks for future programs. PMID:21886686

  8. MeProRisk - a Joint Venture for Minimizing Risk in Geothermal Reservoir Development

    NASA Astrophysics Data System (ADS)

    Clauser, C.; Marquart, G.

    2009-12-01

    Exploration and development of geothermal reservoirs for the generation of electric energy involves high engineering and economic risks due to the need for 3-D geophysical surface surveys and deep boreholes. The MeProRisk project provides a strategy guideline for reducing these risks by combining cross-disciplinary information from different specialists: Scientists from three German universities and two private companies contribute with new methods in seismic modeling and interpretation, numerical reservoir simulation, estimation of petrophysical parameters, and 3-D visualization. The approach chosen in MeProRisk consists in considering prospecting and developing of geothermal reservoirs as an iterative process. A first conceptual model for fluid flow and heat transport simulation can be developed based on limited available initial information on geology and rock properties. In the next step, additional data is incorporated which is based on (a) new seismic interpretation methods designed for delineating fracture systems, (b) statistical studies on large numbers of rock samples for estimating reliable rock parameters, (c) in situ estimates of the hydraulic conductivity tensor. This results in a continuous refinement of the reservoir model where inverse modelling of fluid flow and heat transport allows infering the uncertainty and resolution of the model at each iteration step. This finally yields a calibrated reservoir model which may be used to direct further exploration by optimizing additional borehole locations, estimate the uncertainty of key operational and economic parameters, and optimize the long-term operation of a geothermal resrvoir.

  9. Towards a Socio-Cultural Framework for the Analysis of Joint Student-Teacher Development over Technology-Based Mathematics Lessons

    ERIC Educational Resources Information Center

    Monaghan, John

    2013-01-01

    This paper offers a framework, an extension of Valsiner's "zone theory", for the analysis of joint student-teacher development over a series of technology-based mathematics lessons. The framework is suitable for developing research studies over a moderately long period of time and considers interrelated student-teacher development as…

  10. Broad Autism Phenotype in Typically Developing Children Predicts Performance on an Eye-Tracking Measure of Joint Attention

    PubMed Central

    Serlin, Gayle C.; Siller, Michael

    2015-01-01

    We examined visual attention allocation during a set of social videos that are intended to elicit the coordination of attention with another person, compared to a control condition. Deficits in joint attention are a characteristic of young children with autism spectrum disorder (ASD). Participants included a diverse sample of 50 typically developing school-aged children between 3 and 9 years of age (M = 6:3, SD = 1:8). Results demonstrated that gaze allocation differed significantly between the experimental and control condition. Further, individual differences in gaze allocation were significantly predicted by a parent-report measure evaluating features of the broad autism phenotype. This study contributes to a research program that aims to develop and validate an endophenotype measure of ASD. PMID:22847297

  11. Development and validation of a computational model of the knee joint for the evaluation of surgical treatments for osteoarthritis.

    PubMed

    Mootanah, R; Imhauser, C W; Reisse, F; Carpanen, D; Walker, R W; Koff, M F; Lenhoff, M W; Rozbruch, S R; Fragomen, A T; Dewan, Z; Kirane, Y M; Cheah, K; Dowell, J K; Hillstrom, H J

    2014-01-01

    A three-dimensional (3D) knee joint computational model was developed and validated to predict knee joint contact forces and pressures for different degrees of malalignment. A 3D computational knee model was created from high-resolution radiological images to emulate passive sagittal rotation (full-extension to 65°-flexion) and weight acceptance. A cadaveric knee mounted on a six-degree-of-freedom robot was subjected to matching boundary and loading conditions. A ligament-tuning process minimised kinematic differences between the robotically loaded cadaver specimen and the finite element (FE) model. The model was validated by measured intra-articular force and pressure measurements. Percent full scale error between FE-predicted and in vitro-measured values in the medial and lateral compartments were 6.67% and 5.94%, respectively, for normalised peak pressure values, and 7.56% and 4.48%, respectively, for normalised force values. The knee model can accurately predict normalised intra-articular pressure and forces for different loading conditions and could be further developed for subject-specific surgical planning. PMID:24786914

  12. JANNAF 28th Propellant Development and Characterization Subcommittee and 17th Safety and Environmental Protection Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Mulder, Edwin J. (Editor); Gomez-Knight, Sylvia J. (Editor)

    1999-01-01

    This volume contains 37 unclassified/unlimited-distribution technical papers that were presented at the JANNAF 28th Propellant Development & Characterization Subcommittee (PDCS) and 17th Safety & Environmental Protection Subcommittee (S&EPS) Joint Meeting, held 26-30 April 1999 at the Town & Country Hotel and the Naval Submarine Base, San Diego, California. Volume II contains 29 unclassified/limited-distribution papers that were presented at the 28th PDCS and 17th S&EPS Joint Meeting. Volume III contains a classified paper that was presented at the 28th PDCS Meeting on 27 April 1999. Topics covered in PDCS sessions include: solid propellant rheology; solid propellant surveillance and aging; propellant process engineering; new solid propellant ingredients and formulation development; reduced toxicity liquid propellants; characterization of hypergolic propellants; and solid propellant chemical analysis methods. Topics covered in S&EPS sessions include: space launch range safety; liquid propellant hazards; vapor detection methods for toxic propellant vapors and other hazardous gases; toxicity of propellants, ingredients, and propellant combustion products; personal protective equipment for toxic liquid propellants; and demilitarization/treatment of energetic material wastes.

  13. Development of a Simple Repair Method Using Structural Bonding Tape to Stop Water Leakage from Joints of Small-Scale Concrete Canals

    NASA Astrophysics Data System (ADS)

    Mori, Takehisa; Nakaya, Tetsuo; Ishigami, Akio; Kato, Tomotake

    The study of small-scale concrete canals which had been repaired using simple methods under direct management by farmers or facility managers revealed that the main cause of deterioration of these canals was water leakage caused by failures of joints between sections of the concrete. And the study also revealed that the usual repair methods were insufficiently durable and simple. To solve these problems, a simple repair method was developed in which the canal joints are covered with structural bonding tape and sealant to prevent water leakage. This method satisfied the performance requirements (leak prevention, adhesion, and allowing expansion and contraction of the joint). Moreover, the developed method made farmers possible to repair canal joints in a short time, and no defects in the repaired joints appeared for at least 2 years.

  14. Development of a hinge compatible with the kinematics of the knee joint.

    PubMed

    Bertomeu, José María Baydal; Lois, Juan Manuel Belda; Guillem, Ricard Barberà; Pozo, Alvaro Page Del; Lacuesta, Javiersanchez; Mollà, Carme Gimeno; Luna, Pedro Vera; Pastor, Jaime Prat

    2007-12-01

    This study aims to present a new concept of a knee hinge based on a crossed four-bar linkage mechanism which has been designed to optimally follow a motion curve representing the knee kinematics in the position at which the knee hinge should be placed. The methodology used to determine the optimal knee hinge is based on the optimization of certain variables of the crossed four-bar mechanism using genetic algorithms in order to follow a certain motion curve, which was determined using a biomechanical model of the knee motion. Two current, commercially available knee hinges have been used to theoretically determine their motion by means of the path performed by their instantaneous helical axis. Comparison between these two different knee hinges, Optimal Knee Hinge and the theoretical motion performed by a human knee reveals that a common monocentric hinge has a maximum misalignment of up to 27.2 mm; a polycentric hinge has a maximum misalignment of 23.9 mm. In contrast, the maximum misalignment produced by the Optimal Knee Hinge is 1.99 mm. The orthotic joint presented significantly improves the kinematical compatibility and the adjustment between orthotic and human joint motion, and should provide several advantages in terms of comfort and safety. Furthermore, the determination of the instantaneous helical axis for a particular user, by means of human movement measurement techniques, will enable the optimal crossed four-bar mechanisms to be determined in a customized and personalized manner. As a consequence, this new concept of orthotic knee joint design may improve the adaptability of lower limb orthoses for the user, and may lead to significant advantages in the field of orthotics for the lower limb. PMID:18050008

  15. The joint center for energy storage research: A new paradigm for battery research and development

    NASA Astrophysics Data System (ADS)

    Crabtree, George

    2015-03-01

    The Joint Center for Energy Storage Research (JCESR) seeks transformational change in transportation and the electricity grid driven by next generation high performance, low cost electricity storage. To pursue this transformative vision JCESR introduces a new paradigm for battery research: integrating discovery science, battery design, research prototyping and manufacturing collaboration in a single highly interactive organization. This new paradigm will accelerate the pace of discovery and innovation and reduce the time from conceptualization to commercialization. JCESR applies its new paradigm exclusively to beyond-lithium-ion batteries, a vast, rich and largely unexplored frontier. This review presents JCESR's motivation, vision, mission, intended outcomes or legacies and first year accomplishments.

  16. The joint center for energy storage research: A new paradigm for battery research and development

    SciTech Connect

    Crabtree, George

    2015-03-30

    The Joint Center for Energy Storage Research (JCESR) seeks transformational change in transportation and the electricity grid driven by next generation high performance, low cost electricity storage. To pursue this transformative vision JCESR introduces a new paradigm for battery research: integrating discovery science, battery design, research prototyping and manufacturing collaboration in a single highly interactive organization. This new paradigm will accelerate the pace of discovery and innovation and reduce the time from conceptualization to commercialization. JCESR applies its new paradigm exclusively to beyond-lithium-ion batteries, a vast, rich and largely unexplored frontier. This review presents JCESR's motivation, vision, mission, intended outcomes or legacies and first year accomplishments.

  17. Experiment K-314: Fetal and neonatal rat bone and joint development following in Utero spaceflight

    NASA Technical Reports Server (NTRS)

    Sabelman, E. E.; Holton, E. M.; Arnaud, C. D.

    1981-01-01

    Infant rat limb specimens from Soviet and U.S. ground-based studies were examined by radiography, macrophotography, histologic sectioning and staining and scanning electron microscopy. A comparison was conducted between vivarium and flight-type diets suggesting that nutritional obesity may adversely affect pregnancy. Data were obtained on maturation of ossification centers, orientation of collagen fibers in bone, tendon and ligaments, joint surface texture and spatial relationships of bones of the hind limb. Computer reconstructions of the knee and hip show promise as a means of investigating the etiology of congenital hip dislocation.

  18. Report of a group developing a virtual reality simulator for arthroscopic surgery of the knee joint.

    PubMed

    Cannon, W Dilworth; Eckhoff, Donald G; Garrett, William E; Hunter, Robert E; Sweeney, Howard J

    2006-01-01

    Apprenticeship training of surgical skills is time consuming and can lead to surgical errors. Our group is developing an arthroscopic virtual reality knee simulator for training orthopaedic residents in arthroscopic surgery before live-patient operating room experience. The simulator displays realistic human knee anatomy derived from the Visible Human Dataset developed by the National Library of Medicine and incorporates active force-feedback haptic technology. Our premise is that postgraduate year 2 residents completing a formal virtual education program who are trained to reach a proficiency standard in the techniques and protocol for an arthroscopic knee examination will complete a diagnostic arthroscopy on an actual patient in less time with greater accuracy, less iteration of movement of the arthroscope, and less damage to the patient's tissue compared with residents in the control group learning and practicing the arthroscopic knee examination procedures through the residency program's established education and training program. The validation study, done at eight orthopaedic residency programs, will commence in early 2006 and will take one year to complete. We anticipate that proficiency obtained on the simulator will transfer to surgical skills in the operating room. PMID:16394734

  19. Analysing growth and development of plants jointly using developmental growth stages

    PubMed Central

    Dambreville, Anaëlle; Lauri, Pierre-Éric; Normand, Frédéric; Guédon, Yann

    2015-01-01

    Background and Aims Plant growth, the increase of organ dimensions over time, and development, the change in plant structure, are often studied as two separate processes. However, there is structural and functional evidence that these two processes are strongly related. The aim of this study was to investigate the co-ordination between growth and development using mango trees, which have well-defined developmental stages. Methods Developmental stages, determined in an expert way, and organ sizes, determined from objective measurements, were collected during the vegetative growth and flowering phases of two cultivars of mango, Mangifera indica. For a given cultivar and growth unit type (either vegetative or flowering), a multistage model based on absolute growth rate sequences deduced from the measurements was first built, and then growth stages deduced from the model were compared with developmental stages. Key Results Strong matches were obtained between growth stages and developmental stages, leading to a consistent definition of integrative developmental growth stages. The growth stages highlighted growth asynchronisms between two topologically connected organs, namely the vegetative axis and its leaves. Conclusions Integrative developmental growth stages emphasize that developmental stages are closely related to organ growth rates. The results are discussed in terms of the possible physiological processes underlying these stages, including plant hydraulics, biomechanics and carbohydrate partitioning. PMID:25452250

  20. Review: emerging developments in the use of bioactive glasses for treating infected prosthetic joints.

    PubMed

    Rahaman, Mohamed N; Bal, B Sonny; Huang, Wenhai

    2014-08-01

    Bacterial contamination of implanted orthopedic prostheses is a serious complication that requires prolonged systemic antibiotic therapy, major surgery to remove infected implants, bone reconstruction, and considerable morbidity. Local delivery of high doses of antibiotics using poly(methyl methacrylate) (PMMA) cement as the carrier, along with systemic antibiotics, is the standard treatment. However, PMMA is not biodegradable, and it can present a surface on which secondary bacterial infection can occur. PMMA spacers used to treat deep implant infections must be removed after resolution of the infection. Alternative carrier materials for antibiotics that could also restore deficient bone are therefore of interest. In this article, the development of bioactive glass-based materials as a delivery system for antibiotics is reviewed. Bioactive glass is osteoconductive, converts to hydroxyapatite, and heals to hard and soft tissues in vivo. Consequently, bioactive glass-based carriers can provide the combined functions of controlled local antibiotic delivery and bone restoration. Recently-developed borate bioactive glasses are of particular interest since they have controllable degradation rates coupled with desirable properties related to osteogenesis and angiogenesis. Such glasses have the potential for providing a new class of biomaterials, as substitutes for PMMA, in the treatment of deep bone infections. PMID:24907755

  1. Development of the 50 TW laser for joint experiments with 1 MA z-pinches

    NASA Astrophysics Data System (ADS)

    Wiewior, P. P.; Ivanov, V. V.; Chalyy, O.

    2010-08-01

    A 50 TW high-intensity laser (aka "Leopard" laser) was developed for experiments with the 1 MA z-pinch generator at the University of Nevada, Reno. The laser produces short pulses of 0.35 ps; energy is 15 J. Long pulses are 1 ns; energy is 30 J. The output beam diameter is 80 mm. The Leopard laser applies chirped pulse amplification technology. The laser is based on the 130 fs Ti:Sapphire oscillator, Öffner-type stretcher, Ti:Sapphire regenerative amplifier, mixed Nd:glass rod and disk amplifiers, and vacuum grating compressor. An adaptive optics system ameliorates focusing ability and augments the repetition rate. Two beam terminals are available for experiments: in the vacuum chamber of the z-pinch generator (aka "Zebra"), and a laser-only vacuum chamber (aka "Phoenix" chamber). The Leopard laser coupled to the Zebra z-pinch generator is a powerful diagnostic tool for dense z-pinch plasma. We outline the status, design, architecture and parameters of the Leopard laser, and its coupling to Zebra. We present the methods of laser-based z-pinch plasma diagnostics, which are under development at the University of Nevada, Reno.

  2. Newly developed anatomical and functional ligament reconstruction for the Lisfranc joint fracture dislocations: a case report.

    PubMed

    Hirano, Takaaki; Niki, Hisateru; Beppu, Moroe

    2014-09-01

    A 15-year-old male complained of pain in the left foot that occurred when changing direction while running and at presentation, he had difficulty in walking due to pain and swelling. Plain X-ray of the foot revealed a Myerson Type B2 Lisfranc fracture dislocation, and 3-D computed tomography (CT) revealed proximal fractures of the 2nd-4th metatarsals. The Lisfranc ligament was anatomically reconstructed using a graft of the gracilis tendon. During aftercare, partial weight bearing was permitted at 6 weeks postoperatively and full weight bearing at 8 weeks postoperatively. The patient resumed sporting activities 3 months postoperatively. A plain X-ray taken 12 months postoperatively showed favorable joint congruency, and the patient scored 100 points on the Japanese Society for Surgery of the Foot standard rating system midfoot scale. Our anatomical ligament reconstruction is a useful new method of anatomical reduction and maintenance, and it shortens the duration of aftercare. PMID:25103712

  3. JOINT DEVELOPMENT OF A NATIONAL 1:100,000-SCALE DIGITAL CARTOGRAPHIC DATA BASE.

    USGS Publications Warehouse

    Callahan, George M.; Broome, Frederick R.

    1984-01-01

    The U. S. Geological Survey is beginning a major new program to create a nationwide digital cartographic data base from 1:100,000-scale maps by the end of the decade. This data base will supplement the currently available 1:2,000,000-scale national data base and the selected coverage at 1:24,000-scale. It is anticipated that the data will be useful for both the production of custom graphics and as basic input to geographic information systems. The 1:100,000-scale USGS map series was designed to facilitate automated data capture. The methodologies and procedures used in the data capture process have developed enough so that the two agencies can take advantage of the design features of the 1:100,000-scale maps and work together on complementary tasks to build a digital cartographic data base.

  4. The Joint Experiment for Crop Assessment and Monitoring (JECAM) Initiative: Developing methods and best practices for global agricultural monitoring

    NASA Astrophysics Data System (ADS)

    Champagne, C.; Jarvis, I.; Defourny, P.; Davidson, A.

    2014-12-01

    Agricultural systems differ significantly throughout the world, making a 'one size fits all' approach to remote sensing and monitoring of agricultural landscapes problematic. The Joint Experiment for Crop Assessment and Monitoring (JECAM) was established in 2009 to bring together the global scientific community to work towards a set of best practices and recommendations for using earth observation data to map, monitor and report on agricultural productivity globally across an array of diverse agricultural systems. These methods form the research and development component of the Group on Earth Observation Global Agricultural Monitoring (GEOGLAM) initiative to harmonize global monitoring efforts and increase market transparency. The JECAM initiative brings together researchers from a large number of globally distributed, well monitored agricultural test sites that cover a range of crop types, cropping systems and climate regimes. Each test site works independently as well as together across multiple sites to test methods, sensors and field data collection techniques to derive key agricultural parameters, including crop type, crop condition, crop yield and soil moisture. The outcome of this project will be a set of best practices that cover the range of remote sensing monitoring and reporting needs, including satellite data acquisition, pre-processing techniques, information retrieval and ground data validation. These outcomes provide the research and development foundation for GEOGLAM and will help to inform the development of the GEOGLAM "system of systems" for global agricultural monitoring. The outcomes of the 2014 JECAM science meeting will be discussed as well as examples of methods being developed by JECAM scientists.

  5. Development and evaluation of the measurement system for the human shoulder joint based on the 6 DOF kinematic modelling.

    PubMed

    Shimomura, Y; Iwanaga, K; Harada, H; Katsuura, T

    2000-01-01

    Although numerical models on the shoulder complex joint are currently available, many are impractical because of the procedural complexity coupled with limited and mere simple simulations. The present study defined the clavicle-scapula system as the "base of the humerus" in determining the position of proximal head of humerus, rendering conclusive innovation of a six degree of freedom (DOF) shoulder complex joint model. Furthermore, a complete measurement system where evaluation by calibrating the actual values via the use of an electromagnetic tracking device (ETD) was developed based on the innovated model. The special calibration method using optimizing calculation to work out the rotational center of humerus was employed and actually tested if the theoretical consideration was practically available. As a result of accuracy check experiments, the measurement error was defined within 2-3 mm, indicating sufficient accuracy in studies for human movement. Our findings strongly advocate that the benefit of this novel measurement system would contribute to studies related to shoulder movements in physiological anthropology. PMID:10979249

  6. Development of a biomechanical model of the wrist joint for patient-specific model guided surgical therapy planning: Part 1.

    PubMed

    Eschweiler, Jörg; Stromps, Jan-Philipp; Fischer, Maximilian; Schick, Fabian; Rath, Björn; Pallua, Norbert; Radermacher, Klaus

    2016-04-01

    An enhanced musculoskeletal biomechanical model of the wrist joint is presented in this article. The developed computational model features the two forearm bones radius and ulna, the eight wrist bones, the five metacarpal bones, and a soft tissue apparatus. Validation of the model was based on information taken from the literature as well as own experimental passive in vitro motion analysis of eight cadaver specimens. The computational model is based on the multi-body simulation software AnyBody. A comprehensive ligamentous apparatus was implemented allowing the investigation of ligament function. The model can easily patient specific personalized on the basis of image information. The model enables simulation of individual wrist motion and predicts trends correctly in the case of changing kinematics. Therefore, patient-specific multi-body simulation models are potentially valuable tools for surgeons in pre- and intraoperative planning of implant placement and orientation. PMID:26994117

  7. Development of ASTM Standard for SiC-SiC Joint Testing Final Scientific/Technical Report

    SciTech Connect

    Jacobsen, George; Back, Christina

    2015-10-30

    As the nuclear industry moves to advanced ceramic based materials for cladding and core structural materials for a variety of advanced reactors, new standards and test methods are required for material development and licensing purposes. For example, General Atomics (GA) is actively developing silicon carbide (SiC) based composite cladding (SiC-SiC) for its Energy Multiplier Module (EM2), a high efficiency gas cooled fast reactor. Through DOE funding via the advanced reactor concept program, GA developed a new test method for the nominal joint strength of an endplug sealed to advanced ceramic tubes, Fig. 1-1, at ambient and elevated temperatures called the endplug pushout (EPPO) test. This test utilizes widely available universal mechanical testers coupled with clam shell heaters, and specimen size is relatively small, making it a viable post irradiation test method. The culmination of this effort was a draft of an ASTM test standard that will be submitted for approval to the ASTM C28 ceramic committee. Once the standard has been vetted by the ceramics test community, an industry wide standard methodology to test joined tubular ceramic components will be available for the entire nuclear materials community.

  8. Acromioclavicular joint separations grades I-III: a review of the literature and development of best practice guidelines.

    PubMed

    Reid, Duncan; Polson, Kate; Johnson, Louise

    2012-08-01

    Acromioclavicular joint (ACJ) separation injuries are common injuries among sporting populations. ACJ separations are graded according to severity from grade I being a mild sprain to grade VI, which is severe dislocation with displacement. There is consensus in the literature that grade I-III ACJ separations are managed conservatively and grades IV-VI are managed surgically. Despite conservative care being recommended for lesser grades of injury, there is very little evidence in the literature as to what constitutes conservative care. Therefore, the purpose of this paper was, first, to review the relevant anatomy and kinematics of the ACJ and, second, to review the literature relating to current evidence of conservative management of ACJ injury. Using this data, a best practice guideline for conservative rehabilitation in grade I-III ACJ separations was developed. For the conservative management, a literature search was undertaken using the following databases in the Auckland University of Technology's electronic library resources; MEDLINE, CINAHL, SPORTDiscus™ and the Cochrane Library. The following keywords or phrases were used: 'acromioclavicular joint separations', 'injury', 'dislocations', 'rehabilitation', 'conservative care', 'physiotherapy' and 'exercise'. A total of 24 articles was identified. There were no randomized controlled trials (RCTs) that investigated conservative treatment for grade I-III ACJ sprains. Therefore, a narrative review was formulated covering the anatomy and biomechanics of the ACJ, injury mechanisms and relevant literature reviewed covering rehabilitation principles. Conservative management of grade I-III ACJ separations is still the main recommendation following this review. A best practice guideline for managing grade I-III ACJ separations is presented to help guide clinicians until well constructed RCTs are carried out to improve the conservative management of ACJ injuries. PMID:22784232

  9. [Kinematic investigations of the talocrural joint in human cadaver specimens. Basic studies for the development of a hinged fixator].

    PubMed

    Schmickal, T; Biglari, B; Wentzensen, A

    2002-11-01

    To determine the specifications of a hinged fixator for the upper ankle joint, biomechanical investigations were performed on 20 human cadaver specimens and the talocrural axis was recorded by X-ray cinematography in all levels of the space. The results showed a medium variation of the axis in zero position (mean: 5.8 degrees ) from 3 degrees to 10 degrees in the anterior-posterior view. The span of the axis migration around zero position amounted to a minimum of 3 degrees and a maximum value of 10 degrees (mean: 7.2 degrees ). It could be ascertained that the axis kinetics does not move linearly in all cases. The talus rotation (the axle deviation from the sagittal plane) amounted to a minimum value of 2 degrees and a maximum value of 12 degrees (mean: 5.3 degrees ). In the transverse level, the axis kinetics was tracked by separate X-ray markings of the lateral and medial cortical of the talus in the zero point of the talocrural axis. The results were typical migration curves of the X-ray markings, demonstrating a ventral convex curve at the medial and lateral cortex. This migration of the cortex crossing point of the axis was geometrically entered in a coordinate system. The variance of the axis cortex crossing point at the medial cortical was X(M)=4.2 mm (min: 2 mm, max: 7 mm) and Y(M)=4.7 mm (2-7 mm), at the lateral cortical X(L)=3.7 mm (1-9 mm) and Y(L) =4.1 mm (1-8 mm). Regarding the clinical relevance for the development of a hinged fixator for the upper ankle joint, the results indicate that an external axis guidance of these axoids is not possible, but that an adjusted axis is necessary taking into consideration the values measured using ligamentotaxis. PMID:12436327

  10. Development of phased array ultrasonic testing in lieu of radiography for testing complete joint penetration (CJP) welds

    NASA Astrophysics Data System (ADS)

    Haldipur, P.; Boone, Shane D.

    2014-04-01

    The past decade has seen new, emerging innovation of Ultrasonic Testing (UT). Specifically, multiple manufacturers have produced Phased Array Ultrasonic Testing (PAUT) systems. The PAUT systems embed a matrix of multiple (some up to 128) single transducers into one probe used for scanning elastic materials. Simultaneously exciting multiple transducers offers distinct advantages; depending on the sequencing of transducer excitation, the ultrasonic beam could be steered within the material and multiple beams help develop extra dimensional data to assist with visualization of possible flaws including the discontinuity size, shape and location. Unfortunately, there has not been broad acceptance of PAUT in the bridge fabrication industry because it is currently not a recognized inspection technology in AWS D1.5. One situation in which the technology would excel would be inspection of Complete Joint Penetration (CJP) butt welds. Currently, AWS D1.5 required CJP welds subjected to tensile or reversal stresses only be inspected by Radiographic Testing (RT). However, discontinuities normally seen by RT can also be seen with PAUT. Until specification language is adopted into D1.5, there will continue to be hesitancy to use PAUT for the inspection of CJP butt welds. Developmental work must first be performed to develop the acceptance criteria and the specification language. The developmental work from the inspections carried out on butt-weld specimens and transition butt-weld specimens are presented in this paper. Specific scan plans were developed using the ES-Beam simulation software for each of the test specimens. In depth analysis of PAUT data obtained to determine exact location and sizing information of the defects was performed. The results also present the comparison of results from PAUT to those obtained using conventional UT and radiography.

  11. Development and experience of large conductor cable 35-kV joints at the Los Angeles Department of Water and Power

    SciTech Connect

    Calderon, F.; Findon, E.J. )

    1990-01-01

    The Los Angeles Department of Water and Power (LADWP) places a high priority on developing its distribution system in the most reliable and cost-effective manner. At higher distribution voltages, such as 34.5-kV, jointing systems which are easily, consistently, and quickly installed by both utility and contracted personnel offer significant economic advantages. With increasing loads and higher load densities at LADWP, the use of 34.5-kV, cross-linked polyethylene (CLP) aluminum, 1000-kcmil cable is becoming more common to meet customer load requirements. Two methods of jointing this large conductor cable were historically used, although each method had limitations. This paper provides an overview of LADWP's distribution system, past jointing techniques, the investigation and evaluation of alternate approaches, and the field experience with the joint selected for use.

  12. Maximum voluntary joint torque as a function of joint angle and angular velocity: model development and application to the lower limb.

    PubMed

    Anderson, Dennis E; Madigan, Michael L; Nussbaum, Maury A

    2007-01-01

    Measurements of human strength can be important during analyses of physical activities. Such measurements have often taken the form of the maximum voluntary torque at a single joint angle and angular velocity. However, the available strength varies substantially with joint position and velocity. When examining dynamic activities, strength measurements should account for these variations. A model is presented of maximum voluntary joint torque as a function of joint angle and angular velocity. The model is based on well-known physiological relationships between muscle force and length and between muscle force and velocity and was tested by fitting it to maximum voluntary joint torque data from six different exertions in the lower limb. Isometric, concentric and eccentric maximum voluntary contractions were collected during hip extension, hip flexion, knee extension, knee flexion, ankle plantar flexion and dorsiflexion. Model parameters are reported for each of these exertion directions by gender and age group. This model provides an efficient method by which strength variations with joint angle and angular velocity may be incorporated into comparisons between joint torques calculated by inverse dynamics and the maximum available joint torques. PMID:17485097

  13. Use of a Stochastic Joint Inversion Modeling Algorithm to Develop a Hydrothermal Flow Model at a Geothermal Prospect

    NASA Astrophysics Data System (ADS)

    Tompson, A. F. B.; Mellors, R. J.; Dyer, K.; Yang, X.; Chen, M.; Trainor Guitton, W.; Wagoner, J. L.; Ramirez, A. L.

    2014-12-01

    A stochastic joint inverse algorithm is used to analyze diverse geophysical and hydrologic data associated with a geothermal prospect. The approach uses a Markov Chain Monte Carlo (MCMC) global search algorithm to develop an ensemble of hydrothermal groundwater flow models that are most consistent with the observations. The algorithm utilizes an initial conceptual model descriptive of structural (geology), parametric (permeability) and hydrothermal (saturation, temperature) characteristics of the geologic system. Initial (a-priori) estimates of uncertainty in these characteristics are used to drive simulations of hydrothermal fluid flow and related geophysical processes in a large number of random realizations of the conceptual geothermal system spanning these uncertainties. The process seeks to improve the conceptual model by developing a ranked subset of model realizations that best match all available data within a specified norm or tolerance. Statistical (posterior) characteristics of these solutions reflect reductions in the a-priori uncertainties. The algorithm has been tested on a geothermal prospect located at Superstition Mountain, California and has been successful in creating a suite of models compatible with available temperature, surface resistivity, and magnetotelluric (MT) data. Although the MCMC method is highly flexible and capable of accommodating multiple and diverse datasets, a typical inversion may require the evaluation of thousands of possible model runs whose sophistication and complexity may evolve with the magnitude of data considered. As a result, we are testing the use of sensitivity analyses to better identify critical uncertain variables, lower order surrogate models to streamline computational costs, and value of information analyses to better assess optimal use of related data. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL

  14. Involving Families with Osteogenesis Imperfecta in Health Service Research: Joint Development of the OI/ECE Questionnaire

    PubMed Central

    Dogba, Maman Joyce; Dahan-Oliel, Noémi; Snider, Laurie; Glorieux, Francis H.; Durigova, Michaela; Palomo, Telma; Cordey, Michel; Bédard, Marie-Hélène; Bedos, Christophe; Rauch, Frank

    2016-01-01

    This joint development process generated a tool, with good psychometric properties, that provides unique insight into the experiences of patients and families with OI, the psycho-social impact of the illness, and their service needs and expectations. PMID:26799959

  15. Education Master Plan Update, Issue 6. A Regular Report on Hearings of the Joint Legislative Committee To Develop a Master Plan for Education.

    ERIC Educational Resources Information Center

    Community Coll. League of California, Sacramento.

    California government, college, and university representatives gathered to discuss transfer and articulation issues as part of the ongoing work of the Joint Legislative Committee To Develop a Master Plan for Education. According to attendees: (1) the probable degree attainment rate of a student with direct access to UC or CSU is 70%. In…

  16. A research experiment on facilitation and formation of joint research and development programs between government, industry, and universities: Overview, preliminary findings, and observations

    NASA Technical Reports Server (NTRS)

    Shariq, Syed Z.

    1992-01-01

    Presented is an overview of an experiment to explore the free-market approach to public-private collaboration through the development and implementation of a joint venture mechanism to enable formation of R&D projects between government, industry and academia. Some preliminary results related to time-to-commercialization and economic competitiveness are discussed.

  17. China-Japan enhance joint research cooperation for drug discoveries and development: News from CJMWDDT 2007 in Jinan, China.

    PubMed

    Liu, X Y; Qu, X J; Tang, W

    2007-08-01

    Viral hepatitis is currently a major global cause of morbidity and mortality. In some Asian countries like China and Japan, Hepatitis B and C in particular are the most common extremely infectious diseases and are likely to develop into liver cirrhosis. Furthermore, statistics indicate that patients with liver cirrhosis resulting from hepatitis B and C have an increased risk of developing hepatocellular carcinoma (HCC). Scientists have worked tirelessly to find curative therapeutic strategies to control chronic hepatitis and liver cirrhosis, accompanied by improvements in public health and living conditions. China's Shandong University and the University of Tokyo in Japan previously established a longterm cooperative relationship. Cooperative programs include co-training of postgraduates, exchanges of visiting scholars, academic symposia, and a bilateral international joint research program. Some substantive progress has been made as a result of bilateral endeavors. For instance, the Shandong University China-Japan Cooperation Center for Drug Discovery & Screening (SDU-DDSC) has enhanced to serve as an important platform for further close cooperation. At the same time, the International Advancement Center for Medicine & Health Research (IACMHR) - "Drug Discoveries and Therapeutics" and International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA) - "BioScience Trends" were established (Visit http://www.ddtjournal.com and http://www.biosciencetrends.com ). The first China-Japan conference on new drug discoveries and therapeutics (CJMWDDT 2007) was recently held in Jinan, China May 27-29, 2007, which provided opportunities for further communication and cooperation and increased knowledge of new drug research and clinical cures for hepatitis. Financially supported by the National Natural Science Foundation of China (NSFC) and the Japan Society for the Promotion of Science (JSPS), the conference covered a wide range of topics in

  18. Agriculture and Community Development Interface. Joint Meeting of the Southern Region State Leaders for Agriculture and Natural Resources and Community Resource Development Proceedings (October 8-11, 1989, Williamsburg, Virginia).

    ERIC Educational Resources Information Center

    Warner, Paul D., Ed.; Campbell, Raymond, Ed.

    This document is a summary of remarks presented at a joint meeting of Agriculture and Natural Resources and Community Resource Development state leaders in 1989. The focus of the meeting was economic viability, rural extension and education, water quality, waste management, biotechnology, low-input sustainable agriculture (LISA), and rural…

  19. Upper limb joint position sense during shoulder flexion in healthy individuals: a pilot study to develop a new assessment method

    PubMed Central

    Hood, Victoria

    2015-01-01

    Background Altered shoulder joint position sense (JPS) following shoulder injury has been demonstrated in the literature and may increase the risk of injury. A JPS assessment targeting the shoulder will provide the clinician with an objective marker. The present study aimed to develop an assessment method of JPS using an active relocation test (ART). Methods In total, 40 healthy participants were recruited. A laser-pointer attached to the index finger during an ART allowed measurement (mm) of JPS by measuring the distance between the target and relocated position. Participants were blindfolded and stood an arm’s length (approximately 1 m) away from the wall. Whilst keeping the wrist in neutral and elbow extended, the participant actively moved to the target position (90° glenohumeral flexion), held for 5 seconds, returned their arm to their side and actively returned to the target position. A mean was calculated from three trials to provide an ART score. Results The mean (SD) dominant and nondominant ART score was 89.2 (SD 35.5) mm (95% confidence interval = 77.87 mm to 100.5 mm) and 94.1 (34.5) mm (95% confidence interval = 83.1 mm to 105.2 mm), respectively. Arm dominance did not significantly affect ART scores. Conclusions No significant difference was demonstrated between the dominant and nondominant arm using an ART assessing JPS acuity. Further studies are needed to establish inter-rater and intra-rater reliability.

  20. Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis.

    PubMed

    Kim, Jae-Sung; Ahmadinia, Kasra; Li, Xin; Hamilton, John L; Andrews, Steven; Haralampus, Chris A; Xiao, Guozhi; Sohn, Hong-Moon; You, Jae-Won; Seo, Yo-Seob; Stein, Gary S; Van Wijnen, Andre J; Kim, Su-Gwan; Im, Hee-Jeong

    2015-11-01

    We report generation and characterization of pain-related behavior in a minimally invasive facet joint degeneration (FJD) animal model in rats. FJD was produced by a non-open percutaneous puncture-induced injury on the right lumbar FJs at three consecutive levels. Pressure hyperalgesia in the lower back was assessed by measuring the vocalization response to pressure from a force transducer. After hyperalgesia was established, pathological changes in lumbar FJs and alterations of intervertebral foramen size were assessed by histological and imaging analyses. To investigate treatment options for lumber FJ osteoarthritis-induced pain, animals with established hyperalgesia were administered with analgesic drugs, such as morphine, a selective COX-2 inhibitor, a non-steroidal anti-inflammatory drug (NSAID) (ketorolac), or pregabalin. Effects were assessed by behavioral pain responses. One week after percutaneous puncture-induced injury of the lumbar FJs, ipsilateral primary pressure hyperalgesia developed and was maintained for at least 12 weeks without foraminal stenosis. Animals showed decreased spontaneous activity, but no secondary hyperalgesia in the hind paws. Histopathological and microfocus X-ray computed tomography analyses demonstrated that the percutaneous puncture injury resulted in osteoarthritis-like structural changes in the FJs cartilage and subchondral bone. Pressure hyperalgesia was completely reversed by morphine. The administration of celecoxib produced moderate pain reduction with no statistical significance while the administration of ketorolac and pregabalin produced no analgesic effect on FJ osteoarthritis-induced back pain. Our animal model of non-open percutanous puncture-induced injury of the lumbar FJs in rats shows similar characteristics of low back pain produced by human facet arthropathy. PMID:25858171

  1. Solar Radio Burst Effects and Meteor Effects: Operational Products Under Development at the Joint SMC-AFRL Rapid Prototyping Center

    NASA Astrophysics Data System (ADS)

    Quigley, S.

    2002-05-01

    The Air Force Research Laboratory (AFRL/VSB) and Detachment 11, Space & Missile Systems Center (SMC, Det 11/CIT) have combined efforts to design, develop, test, and implement graphical products for the Air Force's space weather operations center. These products are generated to analyze, specify, and forecast the effects of the near-earth space environment on Department of Defense systems and communications. Jointly-developed products that will be added to real-time operations in the near future include a solar radio background and burst effects (SoRBE) product suite, and a meteor effects (ME) product suite. The SoRBE product addresses the effect of background and event-level solar radio output on operational DoD systems. Strong bursts of radio wave emissions given off by the sun during solar ``events'' can detrimentally affect radar and satellite communication systems that have operational receiving geometries within the field of view of the sun. For some systems, even the background radiation from the sun can produce effects. The radio frequency interference (RFI) of interest occurs on VHF, UHF, and SHF frequency bands, usually lasting several minutes during a solar flare. While such effects are limited in time and area (typically a few degrees in viewing angle), they can be quite severe in magnitude. The result can be a significant lack in a radar system's ability to detect and/or track an object, and loss of a communication system's ability to receive satellite signals. The ME product will address the detrimental effects of meteors on operational DoD systems. These include impacts on satellites, visible trail observations, and radar clutter. While certain types of individual meteors can produce system effects, the initial ME product will address the more generalized range of meteor shower activity and associated affects. These effects can result in damage to satellites, incorrect assessment of satellite sensor observations, and false target returns on radar

  2. Development of compact 500 kV 8000 A gas insulated transmission line-dust control during field jointing and method for detecting conductive particles

    SciTech Connect

    Kaminaga, K.; Koshiishi, M.; Hayashi, T.; Matsuki, M.; Hara, T.; Sugiyama, N.

    1987-10-01

    This paper describes the results of studies made on dust control during field jointing and a method for detecting conductive particles after installation in the development of a compact 500 kV 8000 A gas insulated transmission line (GIL). The study on dust control during field jointing proved that field jointing of the compact GIL can be done like conventional GIL in an easily fabricated vinyl shelter without a clean air flow. Harmful conductive particles can be detected with an Acoustic Emission (AE) sensor. This sensor is effective in improving the reliability of the compact GIL when used with a suitable ac voltage during field test. A 120 m long test line of compact 500 kV 8000 A GIL was constructed and, in a long-term field test, proved to have properties sufficient for practical use.

  3. Development of a technology for laser welding of the 1424 aluminum alloy with a high strength of the welded joint

    NASA Astrophysics Data System (ADS)

    Annin, B. D.; Fomin, V. M.; Karpov, E. V.; Malikov, A. G.; Orishich, A. M.; Cherepanov, A. N.

    2015-11-01

    Results of an experimental study of properties of joints obtained by using different regimes of laser welding of the 1424 alloy (Al-Mg-Li) are reported. The strength and structure of the welded joints are determined. The influence of various types of welded joint straining on its strength is studied. It is demonstrated that the joint strength increases in the case of plastic straining.

  4. Development of the cryo-rotary joint for a HTS synchronous motor with Gd-bulk HTS field-pole magnets

    NASA Astrophysics Data System (ADS)

    Miki, M.; Felder, B.; Tsuzuki, K.; Izumi, M.; Hayakawa, H.

    2010-06-01

    We have studied a prototype of an axial-gap type synchronous motor with Gd-bulk HTS field-pole magnets since 2001. At the liquid nitrogen temperature, these bulks have trapped over 1 T inside the motor after being applied the pulsed field magnetization method. Increasing the flux of the field poles is the most straightforward way of improving the output power of the motor. Cooling down the bulk HTS magnets below the liquid nitrogen temperature provides an effective alternative to increase the magnetic flux trapping. In 2007, we exchanged the cryogen from liquid nitrogen to condensed neon. The key technology of this challenge is a rotary joint, introducing a fluid cryogen into the rotating body in the motor from the static reservoir. We have successfully developed a compact rotary joint which is smaller and lighter than the existent one (1/10 volume, 1/3 length and 1/12 weight). The present joint was manufactured and evaluated with liquid nitrogen and condensed neon. We presume a total heat loss of this rotary joint of less than 10 watts. Successful cooling and rotating tests of the bulk-HTS motor with this novel rotary joint are conducted.

  5. Development of Joint Climate and Discharge Projections for the International Rhine River Basin - the CHR RheinBlick2050 Project

    NASA Astrophysics Data System (ADS)

    Görgen, K.; Pfister, L.

    2008-12-01

    The anticipated climate change will lead to modified hydro-meteorological regimes that influence discharge behaviour and hydraulics of rivers. This has variable impacts on managed (anthropogenic) and unmanaged (natural) systems, depending on their sensitivity and vulnerability (ecology, economy, infrastructure, transport, energy production, water management, etc.). Decision makers in these contexts need adequate adaptation strategies to minimize adverse effects of climate change, i.e. an improved knowledge on the potential impacts including uncertainties means an extension of the informed options open to users. The goal of the highly applied study presented here is the development of joint, consistent climate and discharge projections for the international Rhine River catchments (Switzerland, France, Germany, Netherlands) in order to assess future changes of hydro-meteorological regimes in the meso- and macroscale Rhine River catchments and to derive and improve the understanding of such impacts on hydrologic and hydraulic processes. The RheinBlick2050 project is an international effort initiated by the International Commission for the Hydrology of the Rhine Basin (CHR) in close cooperation with the International Commission for the Protection of the Rhine. The core experiment design foresees a data-synthesis, multi-model approach where (transient) (bias- corrected) regional climate change projections are used as forcing data for existing calibrated hydrological (and hydraulic) models at a daily temporal resolution over mesoscale catchments of the Rhine River. Mainly for validation purposes, hydro-meteorological observations from national weather services are compiled into a new consistent 5 km x 5 km reference dataset from 1961 to 2005. RCM data are mainly used from the ENSEMBLES project and other existing dynamical downscaling model runs to derive probabilistic ensembles and thereby also access uncertainties on a regional scale. A benchmarking is helping to

  6. Fracturing in upper Cretaceous Selma group Chalky marls, inner coastal plain of Alabama: stratigraphic (facies) control of joint development and regional joint-strike orientations

    SciTech Connect

    Bittner, E.; King, D.T. Jr.; Holston, I.

    1988-09-01

    In the inner coastal plain of Alabama, chalky marl is a distinctive sedimentary facies that contains more original biogenic calcareous-nannofossil components than the adjacent marls. The chalky marl is one facies in the cyclically arranged genetic packages that comprise the Mooreville and Demopolis Chalks of the lower part of the Upper Cretaceous Selma Group. Analysis of genetic-package stratigraphy shows that the chalky marls were deposited during relative sea level highstands. The chalky marls are selectively cemented by calcium carbonate, thus making a relatively well-indurated brittle rock. The chalky marls, in three sections over 15 m thick, host most of the systematic joints in the Mooreville and Demopolis. As a result, fracture-density mapping clearly delineates the outcrop belts of the thick fracture-prone chalky marls. Joint systems in the marls and chalky marls have two main strike trends (N30/degrees/E to N70/degrees/E and N20/degrees/W to N50/degrees/W) and two secondary strike trends (north to N10/degrees/E and east-west), which are nearly parallel and perpendicular, respectively, to crystalline bedrock structural trends and fracture zones. Thus, bedrock structural trends and fracture patterns appear to have propagated through the overlying Mesozoic rocks, dictating the orientation of joints in the chalky marls.

  7. Project proposals on the creation of Russian-American joint enterprise for investigation, development and manufacture of power plants on the basis of solid oxide fuel cells

    SciTech Connect

    Smotrov, N.V.; Kleschev, Yu.N.

    1996-04-01

    This paper describes a proposal for a joint Russian-American enterprise for performing scientific investigations, development, and manufacture of fuel cell power plants on the basis of the solid oxide fuel cell. RASOFCo. Russian-American Solid Oxide Fuel Cells Company. RASOFCo will provide the series output of the electrochemical generator (ECG) of 1kW power, then of 5kW and 10kW as well as the development and the output of 10kW power plant with the subsequent output of a power plant of greater power. An ECG based on solid oxide fuel cells uses methane as a fuel. Predicted technical characteristics, market analysis, assessment of potential demands for power plants of low power for Tyumentransgas, participants of the joint enterprise and their founding contributions, strategy for manufacture and financing, and management of RASOFCo are discussed.

  8. Joint development and tectonic stress field evolution in the southeastern Mesozoic Ordos Basin, west part of North China

    NASA Astrophysics Data System (ADS)

    Jiang, Lin; Qiu, Zhen; Wang, Qingchen; Guo, Yusen; Wu, Chaofan; Wu, Zhijie; Xue, Zhenhua

    2016-09-01

    Major joint sets trending E-W (J1), ENE-WSW (J2), NE-SW (J3), N-S (J4), NNW-SSE (J5), NNE-SSW (J6), NW-SE (J7), and WNW-ESE (J8) respectively are recognized in Mesozoic strata within the southeast of Ordos Basin. Among them, the J1, J2 and J3 joint sets are systematic joints, while the other five joint sets (J4, J5, J6, J7, J8) are nonsystematic joints. There are three groups of orthogonal joint systems (i.e. J1 and J4 sets, J2 and J5 sets, and J6 and J8 sets) and two groups of conjugate shear fractures (ENE-WSW and NNE-SSW, ENE-WSW and ESE-WNW) in the study area. Joint spacing analysis indicates that: (1) layer thickness has an effect on the joint spacing, but the correlation of joint spacing and layer thickness is low; (2) joint density of systematic joints is greater than nonsystematic joints, and the joint density of a thin layer is also greater than that of a thick layer; and (3) the joints of Mesozoic strata in the basin are the result of tectonic events affected by multiple stress fields. All these joints in the Mesozoic strata are formed in the two main tectonic events since Late Mesozoic times. One is the westward subduction of the Pacific Plate beneath the Eurasia Plate, which formed the approximately E-W-trending compressive stress field in the China continent. The trends of the J1 joint set (E-W) and the bisector of conjugate shear fractures composed of ENE-WSW and ESE-WNW fractures are all parallel to the trend of maximum compressive stress (E-W). The other stress field is related to the collision of the Indian and Eurasian Plates, which formed the NE-SW-trending compressive stress field in the China continent. The trends of the J3 joint set and bisector of conjugate shear fractures composed of ENE-WSW and NNE-SSW fractures are all parallel to the trend of maximum compressive stress (NE-SW). Finally, we conclude that the J1 and J4 sets are formed in the E-W-trending compressive stress field, and the J2, J3, J5, J6, J7 and J8 sets are formed in the NE

  9. Joint Development of Coated Conductor and Low Cost Thin Film Solar Cells: Cooperative Research and Development Final Report, CRADA Number CRD-007-213

    SciTech Connect

    Bhattacharya, R.

    2011-02-01

    UES plans on developing CIGS thin films by using Metal Organic Deposition (MOD) technique as it is a low-cost, non-vacuum method for scale-up to large area PV modules. NREL will support UES, Inc. through expert processing, characterization and device fabrication. NREL scientists will also help develop a processing phase diagram which includes composition, film thickness, annealing temperature and ambient conditions. Routine measurements of devices and materials will be done under NREL's core support project.

  10. Joint U.S./Russian Study on the Development of a Preliminary Cost Estimate of the SAFSTOR Decommissioning Alternative for the Leningrad Nuclear Power Plant Unit #1

    SciTech Connect

    SM Garrett

    1998-09-28

    The objectives of the two joint Russian/U.S. Leningrad Nuclear Power Plant (NPP) Unit #1 studies were the development of a safe, technically feasible, economically acceptable decom missioning strategy, and the preliminary cost evaluation of the developed strategy. The first study, resulting in the decommissioning strategy, was performed in 1996 and 1997. The preliminary cost estimation study, described in this report, was performed in 1997 and 1998. The decommissioning strategy study included the analyses of three basic RBM.K decommission- ing alternatives, refined for the Leningrad NPP Unit #1. The analyses included analysis of the requirements for the planning and preparation as well as the decommissioning phases.

  11. Joint US/Russian study on the development of a decommissioning strategy plan for RBMK-1000 unit No. 1 at the Leningrad Nuclear Power Plant

    SciTech Connect

    1997-12-01

    The objective of this joint U.S./Russian study was to develop a safe, technically feasible, economically acceptable strategy for decommissioning Leningrad Nuclear Power Plant (LNPP) Unit No. 1 as a representative first-generation RBMK-1000 reactor. The ultimate goal in developing the decommissioning strategy was to select the most suitable decommissioning alternative and end state, taking into account the socioeconomic conditions, the regulatory environment, and decommissioning experience in Russia. This study was performed by a group of Russian and American experts led by Kurchatov Institute for the Russian efforts and by the Pacific Northwest National Laboratory for the U.S. efforts and for the overall project.

  12. Some Ways in Which Neighborhoods, Nuclear Families, Friendship Groups, and Schools Jointly Affect Changes in Early Adolescent Development.

    ERIC Educational Resources Information Center

    Cook, Thomas D.; Herman, Melissa R.; Phillips, Meredith; Settersten, Richard A., Jr.

    2002-01-01

    This study assessed how schools, neighborhoods, nuclear families, and friendship groups jointly contribute to positive change during early adolescence. Analyses showed that the four context indices modestly intercorrelated at the individual student level, but clustered more tightly at the school and neighborhood levels. Joint influence of all four…

  13. Comparison of Extensive Thermal Cycling Effects on Microstructure Development in Micro-alloyed Sn-Ag-Cu Solder Joints

    SciTech Connect

    Anderson, Iver E.; Boesenberg, Adam; Harringa, Joel; Riegner, David; Steinmetz, Andrew; Hillman, David

    2011-09-28

    Pb-free solder alloys based on the Sn-Ag-Cu (SAC) ternary eutectic have promise for widespread adoption across assembly conditions and operating environments, but enhanced microstructural control is needed. Micro-alloying with elements such as Zn was demonstrated for promoting a preferred solidification path and joint microstructure earlier in simple (Cu/Cu) solder joints studies for different cooling rates. This beneficial behavior now has been verified in reworked ball grid array (BGA) joints, using dissimilar SAC305 (Sn-3.0Ag-0.5Cu, wt.%) solder paste. After industrial assembly, BGA components joined with Sn-3.5Ag-0.74Cu-0.21Zn solder were tested in thermal cycling (-55 C/+125 C) along with baseline SAC305 BGA joints beyond 3000 cycles with continuous failure monitoring. Weibull analysis of the results demonstrated that BGA components joined with SAC + Zn/SAC305 have less joint integrity than SAC305 joints, but their lifetime is sufficient for severe applications in consumer, defense, and avionics electronic product field environments. Failure analysis of the BGA joints revealed that cracking did not deviate from the typical top area (BGA component side) of each joint, in spite of different Ag3Sn blade content. Thus, SAC + Zn solder has not shown any advantage over SAC305 solder in these thermal cycling trials, but other characteristics of SAC + Zn solder may make it more attractive for use across the full range of harsh conditions of avionics or defense applications.

  14. Joint Use of Public Schools: Developing a New Social Contract for the Shared Use of Public Schools

    ERIC Educational Resources Information Center

    Filardo, Mary; Vincent, Jeff M.; Allen, Marni; Franklin, Jason

    2010-01-01

    In this paper, the 21st Century School Fund and the Center for Cities and Schools at the University of California Berkeley provide a conceptual frame for the joint use of PK-12 public school buildings. There is a growing conversation about and demand for joint use as a way to provide services to children and families in convenient locations,…

  15. Development of Flow and Heat Transfer Models for the Carbon Fiber Rope in Nozzle Joints of the Space Shuttle Reusable Solid Rocket Motor

    NASA Technical Reports Server (NTRS)

    Wang, Q.; Ewing, M. E.; Mathias, E. C.; Heman, J.; Smith, C.; McCool, Alex (Technical Monitor)

    2001-01-01

    Methodologies have been developed for modeling both gas dynamics and heat transfer inside the carbon fiber rope (CFR) for applications in the space shuttle reusable solid rocket motor joints. Specifically, the CFR is modeled using an equivalent rectangular duct with a cross-section area, friction factor and heat transfer coefficient such that this duct has the same amount of mass flow rate, pressure drop, and heat transfer rate as the CFR. An equation for the friction factor is derived based on the Darcy-Forschheimer law and the heat transfer coefficient is obtained from pipe flow correlations. The pressure, temperature and velocity of the gas inside the CFR are calculated using the one-dimensional Navier-Stokes equations. Various subscale tests, both cold flow and hot flow, have been carried out to validate and refine this CFR model. In particular, the following three types of testing were used: (1) cold flow in a RSRM nozzle-to-case joint geometry, (2) cold flow in a RSRM nozzle joint No. 2 geometry, and (3) hot flow in a RSRM nozzle joint environment simulator. The predicted pressure and temperature history are compared with experimental measurements. The effects of various input parameters for the model are discussed in detail.

  16. Capacity Building in Southern Africa: Experiences and Reflections--Towards Joint Knowledge Production and Social Change in International Development Cooperation

    ERIC Educational Resources Information Center

    Zeelen, Jacques; van der Linden, Josje

    2009-01-01

    The intent of capacity building in international development cooperation is to enable people to control their own development. Important premises are ownership, choice and self-esteem. The authors analyse the dynamics of the enabling process in practice, based on their own experiences working for several years in universities in developing…

  17. The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice

    PubMed Central

    Debusschere, Karlijn; Verschuere, Stephanie; Maes, Tania; De Smet, Rebecca; Conickx, Griet; De Vos, Martine; Laukens, Debby; Joos, Guy F.; Brusselle, Guy G.; Elewaut, Dirk; Cuvelier, Claude A.; Bracke, Ken R.

    2015-01-01

    The inflammatory cytokine TNF-α is a central mediator in many immune-mediated diseases, such as Crohn’s disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor in these TNF-dependent diseases. We exposed TNFΔARE mice; in which a systemic TNF-α overexpression leads to the development of inflammation; to 2 or 4 weeks of air or CS. We investigated the effect of deregulated TNF expression on CS-induced pulmonary inflammation and the effect of CS exposure on the initiation and progression of gut and joint inflammation. Upon 2 weeks of CS exposure, inflammation in lungs of TNFΔARE mice was significantly aggravated. However, upon 4 weeks of CS-exposure, this aggravation was no longer observed. TNFΔARE mice have no increases in CD4+ and CD8+ T cells and a diminished neutrophil response in the lungs after 4 weeks of CS exposure. In the gut and joints of TNFΔARE mice, 2 or 4 weeks of CS exposure did not modulate the development of inflammation. In conclusion, CS exposure does not modulate gut and joint inflammation in TNFΔARE mice. The lung responses towards CS in TNFΔARE mice however depend on the duration of CS exposure. PMID:26523550

  18. Impact of 3-D seismic data on the Nigerian National Petroleum Corporation/Chevron Nigeria Limited joint venture development drilling program

    SciTech Connect

    Quam, S. )

    1993-09-01

    The Nigerian National Petroleum Corporation/Chevron Nigeria Limited joint venture has been acquiring three-dimensional (3-D) seismic data over its concessions since 1984. To date, 1700 km[sup 2] have been recorded and processed at a cumulative cost of US $39 million. During 1991 - 1992, 20 development wells were drilled based directly on new 3-D seismic interpretations. These wells have added 148 million bbl of oil in new recoverable reserves, and to date have added 37,000 bbl/day to the joint venture's production. In addition, the 3-D interpretations have resulted in a sizable inventory of wells for future development drilling. The new 3-D interpretations provided more accurate pictures of fault patterns, fluid contacts, channel trends, stratigraphic continuity, and velocity/amplitude anomalies. In addition, the 3-D data were invaluable in designing low risk, directional well trajectories to tap relatively thin oil legs under large gas caps. Wells often were programmed to hit several objectives at their respective gas/oil contacts, resulting in maximized net oil sand pays and reducing the risk of gas production. In order to do this, directional [open quotes]sharpshooting,[close quotes] accurate depth conversion of the seismic time maps, was critical. By using the 3-D seismic, checkshot, and sonic data to develop a variable velocity space, well-top prognoses within 50 ft at depths of 6,000-10,000 ft were possible, and were key to the success of the program. As the joint venture acreage becomes more mature, development wells will be drilled for smaller numbers of stacked objectives, and sometimes for single sands. Highly accurate 3-D interpretations and depth conversions will become even more critical in order to tap thinner pay zones in a cost-effect manner.

  19. South Asian co-operation in population education. Materials jointly developed for common use by South Asian population education programmes.

    PubMed

    1992-01-01

    Southern Asian population education programs have developed common materials on population and family life education. Countries involved were Bangladesh, India, Nepal, Pakistan, and Sri Lanka. The development of materials occurred as a byproduct of workshop conducted in Nepal from December 3-7, 1990 and December 2-10, 1991 in Sri Lanka. The 1st meeting was organized by UNESCO's Population Education Advisory team, and 6 curriculum topics were identified. Pretesting of materials was conducted between meetings. The final product was a set of 10 posters and 2 comic strips on the quality of life developed by India for elementary level use; a family life and sex education syllabus developed by Sri Lanka for secondary school use; 5 modules with teacher's guides and sample lessons for secondary school use; 5 modules and a teacher's guide on transmission of values on population education by Pakistan; 25 flip charts on maternal and child health for illiterates developed by Nepal; and a field guide on environmental protection for nonformal field workers developed by Bangladesh. Materials were designed through brainstorming sessions, designing of materials by experts, review by other groups, and retesting on target audiences. Revision followed pretesting. The plan for assuring use of materials was to have UNESCO print prototypes and then participants would seek financial support for country supplies. A suggestion was made to leave ample space for insertion of local language captions. Another suggestion was that the cartoon strip "Girls are Pearls" be printed on students' exercise books for all member countries. Member countries should also have available selected materials translated into English and distributed. UNESCO should continue to play the role of facilitator of information and expertise exchange among member countries. Another mutually cooperative activity was the Group Training Course on Population Education for the South Asian subregion held in December 1991. PMID

  20. Joint research and development and exchange of technology on toxic material emergency response between LLNL and ENEA. 1985 progress report

    SciTech Connect

    Dickerson, M.H.; Caracciolo, R.

    1986-01-31

    For the past six years, the US Department of Energy, LLNL, and the ENEA, Rome, Italy, have participated in cooperative studies for improving a systems approach to an emergency response following nuclear accidents. Technology exchange between LLNL and the ENEA was initially confined to the development, application, and evaluation of atmospheric transport and diffusion models. With the emergence of compatible hardware configurations between LLNL and ENEA, exchanges of technology and ideas for improving the development and implementation of systems are beginning to emerge. This report describes cooperative work that has occurred during the past three years, the present state of each system, and recommendations for future exchanges of technology.

  1. Development of Joint Engagement in Young Deaf and Hearing Children: Effects of Chronological Age and Language Skills

    ERIC Educational Resources Information Center

    Cejas, Ivette; Barker, David H.; Quittner, Alexandra L.; Niparko, John K.

    2014-01-01

    Purpose: To evaluate joint engagement (JE) in age-matched children with and without hearing and its relationship to oral language skills. Method: Participants were 180 children with severe-to-profound hearing loss prior to cochlear implant surgery, and 96 age-matched children with normal hearing; all parents were hearing. JE was evaluated in a…

  2. Broad Autism Phenotype in Typically Developing Children Predicts Performance on an Eye-Tracking Measure of Joint Attention

    ERIC Educational Resources Information Center

    Swanson, Meghan R.; Serlin, Gayle C.; Siller, Michael

    2013-01-01

    We examined visual attention allocation during a set of social videos that are intended to elicit the coordination of attention with another person, compared to a control condition. Deficits in joint attention are a characteristic of young children with autism spectrum disorder (ASD). Participants included a diverse sample of 50 typically…

  3. Report on the joint meeting of the Division of Development and Technology Plasma/Wall Interaction and High Heat Flux Materials and Components Task Groups

    SciTech Connect

    Wilson, K.L.

    1985-10-01

    This report of the Joint Meeting of the Division of Development and Technology Plasma/Wall Interaction and High Heat Flux Materials and Components Task Groups contains contributing papers in the following areas: Plasma/Materials Interaction Program and Technical Assessment, High Heat Flux Materials and Components Program and Technical Assessment, Pumped Limiters, Ignition Devices, Program Planning Activities, Compact High Power Density Reactor Requirements, Steady State Tokamaks, and Tritium Plasma Experiments. All these areas involve the consideration of High Heat Flux on Materials and the Interaction of the Plasma with the First Wall. Many of the Test Facilities are described as well. (LSP)

  4. Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development

    PubMed Central

    Alvez, Carlos Sabu; Carvalho de Moraes, Luis Otavio; Marques, Sergio R.; Tedesco, Roberto C.; Harb, Leandro J. C.; Rodríguez-Vázquez, Jose F.; Mérida-Velasco, Jose R.; Alonso, Luis Garcia

    2014-01-01

    Objective. To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial. PMID:24527214

  5. A Smooth Trajectory: Developing Continuity and Progression between Primary and Secondary Science Education through a Jointly-Planned Projectiles Project

    ERIC Educational Resources Information Center

    Davies, Dan; McMahon, Kendra

    2004-01-01

    This article reports on findings from a two-year project--'Improving Science Together'--undertaken in 20 primary and four secondary schools in and around Bristol, UK. The project was funded by the pharmaceutical company AstraZeneca PLC as part of their national Science Teaching Trust initiative, and had as one of its aims the development of…

  6. Adolescent development

    MedlinePlus

    Development - adolescent; Growth and development - adolescent ... During adolescence, children develop the ability to: Understand abstract ideas. These include grasping higher math concepts, and developing moral ...

  7. Development and application of a photogrammetric endoscopic system for measurement of misalignment and internal profile of welded joints in pipelines

    NASA Astrophysics Data System (ADS)

    Albertazzi G., Armando, Jr.; Hofmann, Allan C.; Fantin, Analucia V.; Santos, João M. C.

    2009-06-01

    This paper presents a new optical system to measure internal cylindrical surfaces combining photogrammetry and fringe projection. The device uses two identical cameras, equipped with spherical and conical lenses, facing each other and aligned with the optical axis. A 360° helical fringe projector is used to project a sequence of phase shifted helical fringe pattern in the inner surface to be measured. The phase patterns are used to identify corresponding points and to reconstruct the surface in a regular cylindrical mesh using an alternative approach. A prototype was built, calibrated and tested. The paper presents the results of an application where two welded joints were measured in a 150 mm (6") diameter pipe. The goal was to inspect for defects in the internal part of the welding seams and to measure the transversal misalignment between the jointed parts.

  8. Development and testing of 11- and 24-inch hybrid motors under the joint government/industry IR&D program

    NASA Astrophysics Data System (ADS)

    Boardman, T. A.; Carpenter, R. L.; Goldberg, B. E.; Shaeffer, C. W.

    1993-06-01

    Establishment of a test facility and associated 11-in.-diameter motor for hybrid propulsion technology development at NASA's George C. Marshall Space Flight Center is discussed in this paper. Results of twenty 11-in.-diameter motor tests with a UTF-29901 (60 percent polycyclopentadiene, 40 percent hydroxyl-terminated polybutadiene)/gaseous oxygen propellant system are presented. Tests at this scale have developed fuel regression correlations for comparison with results of yet-to-be-completed, 24-in.-diameter motor tests; demonstrated combustion efficiency levels in the 95 percent range for both single- and multiple-port grain configurations; have shown smooth and stable throttling characteristics over flight-type throttle ranges; and have begun to establish criteria for stable combustion in hybrid motors. The testing of 24-in. motors has not as yet been initiated and is not addressed.

  9. The development of internal repair and rehabilitation techniques for cast iron joints and small diameter steel pipe

    SciTech Connect

    Matsuzaki, M.; Yasui, K.; Tsuji, T.

    1988-01-01

    Osaka Gas Co., Ltd. and Toho Gas Co., Ltd. have accomplished trenchless repair-rehabilitation techniques for cast iron mains, branches, services and house pipes as complete systems in order to maintain its buried pipelines efficiently. An outline of these systems is presented in this paper. Osaka Gas is the second largest and Toho Gas is the third largest gas company in Japan, both gas companies have 5,800,000 customers and pipelines extending approximately to 52,000 km. To maintain such gas pipelines whose length is much more longer than the circumference of the earth, a large amount of investment is required, because excavation of existing pipelines has become more and more difficult. In such a situation, it has become urgent to develop trenchless techniques to repair gas pipelines and to prevent leakage. From these viewpoints Osaka Gas and Toho Gas have developed several complete, internal repair-rehabilitation techniques for cast iron mains, branches, services, and house pipes.

  10. Development and testing of 11- and 24-inch hybrid motors under the joint government/industry IR&D program

    NASA Technical Reports Server (NTRS)

    Boardman, T. A.; Carpenter, R. L.; Goldberg, B. E.; Shaeffer, C. W.

    1993-01-01

    Establishment of a test facility and associated 11-in.-diameter motor for hybrid propulsion technology development at NASA's George C. Marshall Space Flight Center is discussed in this paper. Results of twenty 11-in.-diameter motor tests with a UTF-29901 (60 percent polycyclopentadiene, 40 percent hydroxyl-terminated polybutadiene)/gaseous oxygen propellant system are presented. Tests at this scale have developed fuel regression correlations for comparison with results of yet-to-be-completed, 24-in.-diameter motor tests; demonstrated combustion efficiency levels in the 95 percent range for both single- and multiple-port grain configurations; have shown smooth and stable throttling characteristics over flight-type throttle ranges; and have begun to establish criteria for stable combustion in hybrid motors. The testing of 24-in. motors has not as yet been initiated and is not addressed.

  11. Joint MiRNA/mRNA Expression Profiling Reveals Changes Consistent with Development of Dysfunctional Corpus Luteum after Weight Gain

    PubMed Central

    Bradford, Andrew P.; Jones, Kenneth; Kechris, Katerina; Chosich, Justin; Montague, Michael; Warren, Wesley C.; May, Margaret C.; Al-Safi, Zain; Kuokkanen, Satu

    2015-01-01

    Obese women exhibit decreased fertility, high miscarriage rates and dysfunctional corpus luteum (CL), but molecular mechanisms are poorly defined. We hypothesized that weight gain induces alterations in CL gene expression. RNA sequencing was used to identify changes in the CL transcriptome in the vervet monkey (Chlorocebus aethiops) during weight gain. 10 months of high-fat, high-fructose diet (HFHF) resulted in a 20% weight gain for HFHF animals vs. 2% for controls (p = 0.03) and a 66% increase in percent fat mass for HFHF group. Ovulation was confirmed at baseline and after intervention in all animals. CL were collected on luteal day 7–9 based on follicular phase estradiol peak. 432 mRNAs and 9 miRNAs were differentially expressed in response to HFHF diet. Specifically, miR-28, miR-26, and let-7b previously shown to inhibit sex steroid production in human granulosa cells, were up-regulated. Using integrated miRNA and gene expression analysis, we demonstrated changes in 52 coordinately regulated mRNA targets corresponding to opposite changes in miRNA. Specifically, 2 targets of miR-28 and 10 targets of miR-26 were down-regulated, including genes linked to follicular development, steroidogenesis, granulosa cell proliferation and survival. To the best of our knowledge, this is the first report of dietary-induced responses of the ovulating ovary to developing adiposity. The observed HFHF diet-induced changes were consistent with development of a dysfunctional CL and provide new mechanistic insights for decreased sex steroid production characteristic of obese women. MiRNAs may represent novel biomarkers of obesity-related subfertility and potential new avenues for therapeutic intervention. PMID:26258540

  12. Environmentally Sound Processing Technology: JANNAF Safety and Environmental Protection Subcommittee and Propellant Development and Characterization Subcommittee Joint Workshop

    NASA Technical Reports Server (NTRS)

    Pickett, Lorri A. (Editor)

    1995-01-01

    Topics covered include: Risk assessment of hazardous materials, Automated systems for pollution prevention and hazardous materials elimination, Study design for the toxicity evaluation of ammonium perchlorate, Plasma sprayed bondable stainless surface coatings, Development of CFC-free cleaning processes, New fluorinated solvent alternatives to ozone depleting solvents, Cleaning with highly fluorinated liquids, Biotreatment of propyleneglycol nitrate by anoxic denitrification, Treatment of hazardous waste with white rot fungus, Hydrothermal oxidation as an environmentally benign treatment technology, Treatment of solid propellant manufacturing wastes by base hydrolysis, Design considerations for cleaning using supercritical fluid technology, and Centrifugal shear carbon dioxide cleaning.

  13. Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo.

    PubMed

    Yin, Jian; Yang, Jian-ming; Zhang, Feng; Miao, Peng; Lin, Ying; Chen, Ming-li

    2014-09-01

    This paper aims to evaluate the individual and joint toxicities of cadmium sulfate (CdSO4) and α-naphthoflavone (ANF) in zebrafish embryos. As a result, CdSO4 caused both lethal and sub-lethal effects, such as 24 h post-fertilization (hpf) death and 72 hpf delayed hatching. However, ANF only caused sub-lethal effects, including 48 hpf cardiac edema and 72 hpf delayed hatching. Taking 24 hpf death and 48 hpf cardiac edema as endpoints, the toxicities of CdSO4 and ANF were significantly enhanced by each other. Consistently, both CdSO4 and ANF caused significant oxidative stress, including decreases in the reduced glutathione (GSH) level, inhibition of superoxide dismutase (SOD) activity, as well as increases in malondialdehyde (MDA) content in zebrafish embryos, but these mixtures produced much more significant alterations on the biomarkers. Co-treatment of CdSO4 and ANF significantly down-regulated the mRNA level of multidrug resistance-associated protein (mrp) 1 and cytochrome P450 (cyp) 1a, which constituted the protective mechanisms for zebrafish embryos to chemical toxins. In conclusion, co-treatment of CdSO4 and ANF exhibited a much more severe damage in zebrafish embryos than individual treatment. Meanwhile, production of oxidative stress and altered expression of mrp1 and cyp1a could be important components of such joint toxicity. PMID:25183031

  14. Expression of MMP-2 and MMP-9 in the rat trigeminal ganglion during the development of temporomandibular joint inflammation

    PubMed Central

    Nascimento, G.C.; Rizzi, E.; Gerlach, R.F.; Leite-Panissi, C.R.A.

    2013-01-01

    Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs). This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs). TMJ inflammation is considered to be a cause of pain in patients with TMD. Extracellular proteolytic enzymes, specifically the matrix metalloproteinases (MMPs), have been shown to modulate inflammation and pain. The purpose of this investigation was to determine whether the expression and level of gelatinolytic activity of MMP-2 and MMP-9 in the trigeminal ganglion are altered during different stages of temporomandibular inflammation, as determined by gelatin zymography. This study also evaluated whether mechanical allodynia and orofacial hyperalgesia, induced by the injection of complete Freund's adjuvant into the TMJ capsule, were altered by an MMP inhibitor (doxycycline, DOX). TMJ inflammation was measured by plasma extravasation in the periarticular tissue (Evans blue test) and infiltration of polymorphonuclear neutrophils into the synovial fluid (myeloperoxidase enzyme quantification). MMP expression in the trigeminal ganglion was shown to vary during the phases of the inflammatory process. MMP-9 regulated the early phase and MMP-2 participated in the late phase of this process. Furthermore, increases in plasma extravasation in periarticular tissue and myeloperoxidase activity in the joint tissue, which occurred throughout the inflammation process, were diminished by treatment with DOX, a nonspecific MMP inhibitor. Additionally, the increases of mechanical allodynia and orofacial hyperalgesia were attenuated by the same treatment. PMID:24270905

  15. Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo*

    PubMed Central

    Yin, Jian; Yang, Jian-ming; Zhang, Feng; Miao, Peng; Lin, Ying; Chen, Ming-li

    2014-01-01

    This paper aims to evaluate the individual and joint toxicities of cadmium sulfate (CdSO4) and α-naphthoflavone (ANF) in zebrafish embryos. As a result, CdSO4 caused both lethal and sub-lethal effects, such as 24 h post-fertilization (hpf) death and 72 hpf delayed hatching. However, ANF only caused sub-lethal effects, including 48 hpf cardiac edema and 72 hpf delayed hatching. Taking 24 hpf death and 48 hpf cardiac edema as endpoints, the toxicities of CdSO4 and ANF were significantly enhanced by each other. Consistently, both CdSO4 and ANF caused significant oxidative stress, including decreases in the reduced glutathione (GSH) level, inhibition of superoxide dismutase (SOD) activity, as well as increases in malondialdehyde (MDA) content in zebrafish embryos, but these mixtures produced much more significant alterations on the biomarkers. Co-treatment of CdSO4 and ANF significantly down-regulated the mRNA level of multidrug resistance-associated protein (mrp) 1 and cytochrome P450 (cyp) 1a, which constituted the protective mechanisms for zebrafish embryos to chemical toxins. In conclusion, co-treatment of CdSO4 and ANF exhibited a much more severe damage in zebrafish embryos than individual treatment. Meanwhile, production of oxidative stress and altered expression of mrp1 and cyp1a could be important components of such joint toxicity. PMID:25183031

  16. Republic of Bulgaria Sreden Iskar Cascade hydropower development. Application for participation under the United States Initiative on Joint Implementation

    SciTech Connect

    1998-11-01

    Interest in water resources and hydropower has been low in Bulgaria for over 20 years and only about 33% of the potential hydropower available to the Country are currently being utilized. This is due in part to past design practices that utilized large reservoirs to regulate runoff and create the necessary head. The Iskar River does not allow for the typical design. However, in recent years, technical advancement in machinery design and more efficient turbine-generators has led to the development of low-head hydro projects. Studies determined that the Iskar Cascade can support low-head hydro development and could provide as much as 93 MW of capacity. This project will initially consist of the construction of three hydroelectric facilities along a 120-km section of the Iskar river in western Bulgaria. Each facility will consist of a powerhouse (housing a turbine and generator), an embankment dam, a concrete spillway with regulating gates, a fish passage, and associated transformers and switchgear. This report gives a description of the project, its sources of funding for specific measures to reduce greenhouse gas emissions, forecasts of greenhouse gas emissions with and without these specific measures, and other environmental considerations.

  17. Probing emissions of military cargo aircraft: description of a joint field measurement Strategic Environmental Research and Development Program.

    PubMed

    Cheng, Meng-Dawn; Corporan, Edwin; DeWitt, Matthew J; Spicer, Chester W; Holdren, Michael W; Cowen, Kenneth A; Laskin, Alex; Harris, David B; Shores, Richard C; Kagann, Robert; Hashmonay, Ram

    2008-06-01

    To develop effective air quality control strategies for military air bases, there is a need to accurately quantify these emissions. In support of the Strategic Environmental Research and Development Program project, the particulate matter (PM) and gaseous emissions from two T56 engines on a parked C-130 aircraft were characterized at the Kentucky Air National Guard base in Louisville, KY. Conventional and research-grade instrumentation and methodology were used in the field campaign during the first week of October 2005. Particulate emissions were sampled at the engine exit plane and at 15 m downstream. In addition, remote sensing of the gaseous species was performed via spectroscopic techniques at 5 and 15 m downstream of the engine exit. It was found that PM mass and number concentrations measured at 15-m downstream locations, after dilution-correction generally agreed well with those measured at the engine exhaust plane; however, higher variations were observed in the far-field after natural dilution of the downstream measurements was accounted for. Using carbon dioxide-normalized data we demonstrated that gas species measurements by extractive and remote sensing techniques agreed reasonably well. PMID:18581808

  18. Development of Torque Sensor with High Sensitivity for Joint of Robot Manipulator Using 4-Bar Linkage Shape

    PubMed Central

    Zhang, Hong-Xia; Ryoo, Young-Jae; Byun, Kyung-Seok

    2016-01-01

    The torque sensor is used to measure the joint torque of a robot manipulator. Previous research showed that the sensitivity and the stiffness of torque sensors have trade-off characteristics. Stiffness has to be sacrificed to increase the sensitivity of the sensor. In this research, a new torque sensor with high sensitivity (TSHS) is proposed in order to resolve this problem. The key idea of the TSHS comes from its 4-bar linkage shape in which the angular displacement of a short link is larger than that of a long link. The sensitivity of the torque sensor with a 4-bar link shape is improved without decreasing stiffness. Optimization techniques are applied to maximize the sensitivity of the sensor. An actual TSHS is constructed to verify the validity of the proposed mechanism. Experimental results show that the sensitivity of TSHS can be increased 3.5 times without sacrificing stiffness. PMID:27376304

  19. Development of Torque Sensor with High Sensitivity for Joint of Robot Manipulator Using 4-Bar Linkage Shape.

    PubMed

    Zhang, Hong-Xia; Ryoo, Young-Jae; Byun, Kyung-Seok

    2016-01-01

    The torque sensor is used to measure the joint torque of a robot manipulator. Previous research showed that the sensitivity and the stiffness of torque sensors have trade-off characteristics. Stiffness has to be sacrificed to increase the sensitivity of the sensor. In this research, a new torque sensor with high sensitivity (TSHS) is proposed in order to resolve this problem. The key idea of the TSHS comes from its 4-bar linkage shape in which the angular displacement of a short link is larger than that of a long link. The sensitivity of the torque sensor with a 4-bar link shape is improved without decreasing stiffness. Optimization techniques are applied to maximize the sensitivity of the sensor. An actual TSHS is constructed to verify the validity of the proposed mechanism. Experimental results show that the sensitivity of TSHS can be increased 3.5 times without sacrificing stiffness. PMID:27376304

  20. The Joint Space Operations Center (JSpOC) Mission System (JMS) and the Advanced Research, Collaboration, and Application Development Environment (ARCADE)

    NASA Astrophysics Data System (ADS)

    Johnson, K.; Kim, R.; Echeverry, J.

    The Joint Space Operations Center (JSpOC) is a command and control center focused on executing the Space Control mission of the Joint Functional Component Command for Space (JFCC-SPACE) to ensure freedom of action of United States (US) space assets, while preventing adversary use of space against the US. To accomplish this, the JSpOC tasks a network of space surveillance sensors to collect Space Situational Awareness (SSA) data on resident space objects (RSOs) in near earth and deep space orbits. SSA involves the ingestion of data sources and use of algorithms and tools to build, maintain, and disseminate situational awareness of RSOs in space. On the heels of emergent and complex threats to space assets, the JSpOC's capabilities are limited by legacy systems and CONOPs. The JSpOC Mission System (JMS) aims to consolidate SSA efforts across US agencies, international partners, and commercial partners. The JMS program is intended to deliver a modern service-oriented architecture (SOA) based infrastructure with increased process automation and improved tools to remove the current barriers to JSpOC operations. JMS has been partitioned into several developmental increments. Increment 1, completed and operational in early 2013, and Increment 2, which is expected to be completed in 2016, will replace the legacy Space Defense Operations Center (SPADOC) and Astrodynamics Support Workstation (ASW) capabilities. In 2017 JMS Increment 3 will continue to provide additional SSA and C2 capabilities that will require development of new applications and procedures as well as the exploitation of new data sources. Most importantly, Increment 3 is uniquely postured to evolve the JSpOC into the centralized and authoritative source for all Space Control applications by using its SOA to aggregate information and capabilities from across the community. To achieve this goal, Scitor Corporation has supported the JMS Program Office as it has entered into a partnership with AFRL/RD (Directed

  1. Review of US Nanocorp - SNL Joint Development of Thermal-Sprayed Thin-Film Cathodes for Thermal Batteries

    SciTech Connect

    GUIDOTTI,RONALD A.; REINHARDT,FREDERICK W.; DAI,JINXIANG; XIAO,T. DANNY; REISNER,DAVID E.

    2000-11-14

    The use of plasma spray to deposit thin metal-sulfide cathode films is described in this paper. Conventional electroactive stack components in thermal batteries are constructed from pressed-powder parts that are difficult to fabricate in large diameters in thicknesses <0.010. Plasma-sprayed electrodes do not steer from this difficulty, allowing greater energy densities and specific energies to be realized. Various co-spraying agents have been found suitable for improving the mechanical as well as electrochemical properties of plasma-sprayed cathodes for thermal batteries. These electrodes generally show equal or improved performance over conventional pressed-powder electrodes. A number of areas for future growth and development of plasma-spray technology is discussed.

  2. Development, assembly, and validation of an SMA-actuated two-joint nozzle and six-channel power supply for use in a smart inhaler system

    NASA Astrophysics Data System (ADS)

    Furst, Stephen J.; Hangekar, Rohan; Seelecke, Stefan

    2010-04-01

    The Smart Inhaler design concept recently developed at NC State University has the potential to target the delivery of inhaled aerosol medication to specified locations within the lung system. This targeted delivery could help patients with pulmonary ailments by reducing the exposure of healthy lung tissue to potentially harmful medications. However, controlled delivery can only be accomplished if medication is injected at a precise location in an inhaled stream of properly conditioned laminar flow. In particular, the medication must be injected into the inhaled flow using a small nozzle that can be positioned without disturbing the flow. This paper outlines the procedure used to assemble and control a key component of the smart inhaler: a shape memory alloy (SMA) based dual-joint flexible nozzle that exploits the sensing and actuating capabilities of thermally activated SMA wires. A novel 6-channel power-supply is used to control input power and measure the resistance across the SMA. Since a practical fabrication process may result in SMA wires with different contact resistances, the power supply employs an initialization procedure to self-calibrate and provide normalized power distribution 6 SMA wires simultaneously. Furthermore, a robust control scheme is used to ensure that a constant current is provided to the wires. In validation tests, a LabVIEW-based video positioning system was used to measure the deflection of the nozzle tip and joint rotation. Results show that the carefully controlled assembly of a stream-lined nozzle can produce a practical smart structure, and joint rotation is predictable and repeatable when power input is also controlled. Future work will assess the use of the SMA-resistance measurement as position feedback and PID position control power as a measurement of the convective cooling that results from the moving airflow.

  3. The Joint Space Operations Center (JSpOC) Mission System (JMS) and the Advanced Research, Collaboration, and Application Development Environment (ARCADE)

    NASA Astrophysics Data System (ADS)

    Johnson, K.; Kim, R.; Echeverry, J.

    The Joint Space Operations Center (JSpOC) is a command and control center focused on executing the Space Control mission of the Joint Functional Component Command for Space (JFCC-SPACE) to ensure freedom of action of United States (US) space assets, while preventing adversary use of space against the US. To accomplish this, the JSpOC tasks a network of space surveillance sensors to collect Space Situational Awareness (SSA) data on resident space objects (RSOs) in near earth and deep space orbits. SSA involves the ingestion of data sources and use of algorithms and tools to build, maintain, and disseminate situational awareness of RSOs in space. On the heels of emergent and complex threats to space assets, the JSpOC's capabilities are limited by legacy systems and CONOPs. The JSpOC Mission System (JMS) aims to consolidate SSA efforts across US agencies, international partners, and commercial partners. The JMS program is intended to deliver a modern service-oriented architecture (SOA) based infrastructure with increased process automation and improved tools to remove the current barriers to JSpOC operations. JMS has been partitioned into several developmental increments. Increment 1, completed and operational in early 2013, and Increment 2, which is expected to be completed in 2016, will replace the legacy Space Defense Operations Center (SPADOC) and Astrodynamics Support Workstation (ASW) capabilities. In 2017 JMS Increment 3 will continue to provide additional SSA and C2 capabilities that will require development of new applications and procedures as well as the exploitation of new data sources. Most importantly, Increment 3 is uniquely postured to evolve the JSpOC into the centralized and authoritative source for all Space Control applications by using its SOA to aggregate information and capabilities from across the community. To achieve this goal, Scitor Corporation has supported the JMS Program Office as it has entered into a partnership with AFRL/RD (Directed

  4. A newly developed snow vehicle (SM100S) for Antarctica. Part 3: Low temperature toughness of the welded joints of the structural steel

    NASA Astrophysics Data System (ADS)

    Sakui, Shin; Nakajima, Masashi

    1992-11-01

    For the purpose of developing a new snow vehicle (common use at temperature about -50 C) for the deep ice coring project at Dome Fuji, East Antarctica, the low temperature toughness of the welded joints of structural steel was investigated. It is empirically well known that in case of vehicles employed in a cold air temperature of about -50 C, the low temperature brittle fracture of the structural members does not take place, if one uses semi-killed or killed steel, for which 50 percent FATT's (fracture appearance transition temperature) of the Charpy impact test is about -50 C and Charpy impact values at -50 C are 20 to 29 J/sq cm. In the present report, the Charpy impact test has been performed for both single pass SMAW (shield metal arc welding) and CO2 arc welded joints of JIS (Japan Industrial Standards) steels of SS400, SL2N255, STPL380, and STPL450. The test results show that the JIS steels of SL2N255 and STPL450 can be used for the new vehicle, considering their toughness.

  5. Digital correction of magnification in pelvic x rays for preoperative planning of hip joint replacements: Theoretical development and clinical results of a new protocol

    SciTech Connect

    The, B.; Diercks, R.L.; Stewart, R.E.; Ooijen, P.M.A. van; Horn, J.R. van

    2005-08-15

    The introduction of digital radiological facilities leads to the necessity of digital preoperative planning, which is an essential part of joint replacement surgery. To avoid errors in the preparation and execution of hip surgery, reliable correction of the magnification of the projected hip is a prerequisite. So far, no validated method exists to accomplish this. We present validated geometrical models of the x-ray projection of spheres, relevant for the calibration procedure to correct for the radiographic magnification. With help of these models a new calibration protocol was developed. The validity and precision of this procedure was determined in clinical practice. Magnification factors could be predicted with a maximal margin of error of 1.5%. The new calibration protocol is valid and reliable. The clinical tests revealed that correction of magnification has a 95% margin of error of -3% to +3%. Future research might clarify if a strict calibration protocol, as presented in this study, results in more accurate preoperative planning of hip joint replacements.

  6. [Joint locus of a/b-globin genes in Danio rerio is segregated into structural subdomains active at different stages of development].

    PubMed

    Dolgushin, K V; Petrova, N V; Iudinkova, E S; Razin, S V; Iarovaia, O V

    2015-01-01

    In the domain model of eukaryotic genome organization, the functional unit of the genome, along with the relevant regulatory elements, is considered to be a gene or a gene family. In hot-blooded vertebrate animals, the domains of a- and b-globin genes are positioned at different chromosomes and are organized and regulated in different fashion. In cold-blooded animals, in particular in tropical fish Danio rerio, a- and b globin genes are located in a common gene cluster. However, the joint a/b-globin gene cluster is subdivided into two development stage-specific subdomains, the adult one and the embryonic-larval one. In an attempt to find out whether this functional segregation correlates with structural segregation of the domain we compared the DNase I sensitivity and profiles of histone modifications of adult and embryonic-larval segments of the domain in cultured D. rerio fibroblasts. We have demonstrated that, in these nonerythroid cells, adult and embryonic- larval subdomains possess different DNase I sensitivities and different profiles of H3K27me3, a histone modification introduced by PRC2 complex. These observations suggest that joint a/b globin gene domain of Danio rerio is segregated into two structural subdomain harboring adult and embryonic-larval globin genes. PMID:26107904

  7. A joint modeling approach for uncovering associations between gene expression, bioactivity and chemical structure in early drug discovery to guide lead selection and genomic biomarker development.

    PubMed

    Perualila-Tan, Nolen; Kasim, Adetayo; Talloen, Willem; Verbist, Bie; Göhlmann, Hinrich W H; Shkedy, Ziv

    2016-08-01

    The modern drug discovery process involves multiple sources of high-dimensional data. This imposes the challenge of data integration. A typical example is the integration of chemical structure (fingerprint features), phenotypic bioactivity (bioassay read-outs) data for targets of interest, and transcriptomic (gene expression) data in early drug discovery to better understand the chemical and biological mechanisms of candidate drugs, and to facilitate early detection of safety issues prior to later and expensive phases of drug development cycles. In this paper, we discuss a joint model for the transcriptomic and the phenotypic variables conditioned on the chemical structure. This modeling approach can be used to uncover, for a given set of compounds, the association between gene expression and biological activity taking into account the influence of the chemical structure of the compound on both variables. The model allows to detect genes that are associated with the bioactivity data facilitating the identification of potential genomic biomarkers for compounds efficacy. In addition, the effect of every structural feature on both genes and pIC50 and their associations can be simultaneously investigated. Two oncology projects are used to illustrate the applicability and usefulness of the joint model to integrate multi-source high-dimensional information to aid drug discovery. PMID:27269248

  8. Management of open bite that developed during treatment for internal derangement and osteoarthritis of the temporomandibular joint

    PubMed Central

    Choi, Jae Won; Nakaoka, Kazutoshi; Hamada, Yoshiki; Nakamura, Yoshiki

    2015-01-01

    This case report describes the orthodontic treatment performed for open bite caused by internal derangement (ID) and osteoarthritis (OA) of the temporomandibular joint (TMJ). A Japanese woman, aged 31 years and 11 months, referred to our department by an oral surgeon had an open bite with clockwise rotation of the mandible and degeneration of the condyle. The overbite was corrected through intrusion of the maxillary and mandibular molars using mini-screw implants to induce counterclockwise rotation of the mandible. Then, the mandibular second premolars were extracted and comprehensive orthodontic treatment was performed to establish a Class I molar relationship with distalization of the maxillary arch and to eliminate anterior crowding. Following treatment, her facial profile improved and a functional and stable occlusion was achieved without recurrence of the TMJ symptoms. These results suggest that orthodontic intrusion of the molars is one of the safer and less stressful alternatives for the management of open bite due to degeneration of the condyles caused by ID and OA of TMJ. PMID:26023542

  9. Management of open bite that developed during treatment for internal derangement and osteoarthritis of the temporomandibular joint.

    PubMed

    Arai, Chihiro; Choi, Jae Won; Nakaoka, Kazutoshi; Hamada, Yoshiki; Nakamura, Yoshiki

    2015-05-01

    This case report describes the orthodontic treatment performed for open bite caused by internal derangement (ID) and osteoarthritis (OA) of the temporomandibular joint (TMJ). A Japanese woman, aged 31 years and 11 months, referred to our department by an oral surgeon had an open bite with clockwise rotation of the mandible and degeneration of the condyle. The overbite was corrected through intrusion of the maxillary and mandibular molars using mini-screw implants to induce counterclockwise rotation of the mandible. Then, the mandibular second premolars were extracted and comprehensive orthodontic treatment was performed to establish a Class I molar relationship with distalization of the maxillary arch and to eliminate anterior crowding. Following treatment, her facial profile improved and a functional and stable occlusion was achieved without recurrence of the TMJ symptoms. These results suggest that orthodontic intrusion of the molars is one of the safer and less stressful alternatives for the management of open bite due to degeneration of the condyles caused by ID and OA of TMJ. PMID:26023542

  10. Development of Joint Engagement in Young Deaf and Hearing Children: Effects of Chronological Age and Language Skills

    PubMed Central

    Cejas, Ivette; Barker, David H.; Quittner, Alexandra L.; Niparko, John K.

    2015-01-01

    Purpose To evaluate joint engagement (JE) in age-matched children with and without hearing and its relationship to oral language skills. Method Participants were 180 children with severe-to-profound hearing loss prior to cochlear implant surgery, and 96 age-matched children with normal hearing; all parents were hearing. JE was evaluated in a 10-minute videotaped free play task with parents. Engagement states ranged from the lowest (unengaged) to the highest level (symbol-infused coordinated). Standardized language measures were administered. Results Multivariate analyses were conducted between the groups, stratified by chronological and language age. Children who were deaf (Deaf) spent less time in total symbol-infused JE than children with normal hearing (NH) across all ages. The majority of the Deaf group (83%) fell in the lowest language age group, in comparison to 35% of the NH group, and spent significantly less time in symbol-infused JE than hearing children. These delays were also observed in the Deaf group, who fell into the 18-36 month language age. No children in the Deaf group had achieved a language age of >36 months. Conclusions Young children with and without hearing had different developmental trajectories of JE, which were related to oral language skills. PMID:24845423

  11. The Development of the Joint NASA GSFC and the National Imagery and Mapping Agency (NIMA) Geopotential Model EGM96

    NASA Technical Reports Server (NTRS)

    Lemoine, F. G.; Kenyon, S.C.; Factor, J. K.; Trimmer, R. G.; Pavlis, N. K.; Chinn, D. S.; Cox, C. M.; Klosko, S. M.; Luthcke, S. B.; Torrence, M. H.; Wang, Y. M.; Williamson, R. G.; Pavlis, E. C.; Rapp, R. H.; Olson, T. R.

    1998-01-01

    The NASA Goddard Space Flight Center (GSFC), the National Imagery and Mapping Agency (NIMA), and The Ohio State University (OSU) have collaborated to develop an improved spherical harmonic model of the Earth's gravitational potential to degree 360. The new model, Earth Gravitational Model 1996 (EGM96), incorporates improved surface gravity data, altimeter-derived gravity anomalies from ERS-1 and from the GEOSAT Geodetic Mission (GM), extensive satellite tracking data-including new data from Satellite Laser Ranging (SLR), the Global Postioning System (GPS), NASA's Tracking and Data Relay Satellite System (TDRSS), the French DORIS system, and the US Navy TRANET Doppler tracking system-as well as direct altimeter ranges from TOPEX/POSEIDON (T/P), ERS-1, and GEOSAT. The final solution blends a low-degree combination model to degree 70, a block-diagonal solution from degree 71 to 359, and a quadrature solution at degree 360. The model was used to compute geoid undulations accurate to better than one meter (with the exception of areas void of dense and accurate surface gravity data) and realize WGS84 as a true three-dimensional reference system. Additional results from the EGM96 solution include models of the dynamic ocean topography to degree 20 from T/P and ERS-1 together, and GEOSAT separately, and improved orbit determination for Earth-orbiting satellites.

  12. Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach.

    PubMed

    Cokelaere, Stefan; Malda, Jos; van Weeren, René

    2016-08-01

    Chondral and osteochondral lesions due to injury or other pathology are highly prevalent conditions in horses (and humans) and commonly result in the development of osteoarthritis and progression of joint deterioration. Regenerative medicine of articular cartilage is an emerging clinical treatment option for patients with articular cartilage injury or disease. Functional articular cartilage restoration, however, remains a major challenge, but the field is progressing rapidly and there is an increasing body of supportive clinical and scientific evidence. This review gives an overview of the established and emerging surgical techniques employed for cartilage repair in horses. Through a growing insight in surgical cartilage repair possibilities, surgeons might be more stimulated to explore novel techniques in a clinical setting. PMID:27387728

  13. DOE-NE Light Water Reactor Sustainability Program and EPRI Long-Term Operations Program. Joint Research and Development Plan

    SciTech Connect

    Williams, Don

    2014-04-01

    Nuclear power has contributed almost 20% of the total amount of electricity generated in the United States over the past two decades. High capacity factors and low operating costs make nuclear power plants (NPPs) some of the most economical power generators available. Further, nuclear power remains the single largest contributor (nearly 70%) of non-greenhouse gas-emitting electric power generation in the United States. Even when major refurbishments are performed to extend operating life, these plants continue to represent cost-effective, low-carbon assets to the nation’s electrical generation capability. By the end of 2014, about one-third of the existing domestic fleet will have passed their 40th anniversary of power operations, and about one-half of the fleet will reach the same 40-year mark within this decade. Recognizing the challenges associated with pursuing extended service life of commercial nuclear power plants, the U.S. Department of Energy’s (DOE) Office of Nuclear Energy (NE) and the Electric Power Research Institute (EPRI) have established separate but complementary research and development programs (DOE-NE’s Light Water Reactor Sustainability [LWRS] Program and EPRI’s Long-Term Operations [LTO] Program) to address these challenges. To ensure that a proper linkage is maintained between the programs, DOE-NE and EPRI executed a memorandum of understanding in late 2010 to “establish guiding principles under which research activities (between LWRS and LTO) could be coordinated to the benefit of both parties.” This document represents the third annual revision to the initial version (March 2011) of the plan as called for in the memorandum of understanding.

  14. Information basis for developing comprehensive waste management system-US-Japan joint nuclear energy action plan waste management working group phase I report.

    SciTech Connect

    Nutt, M.; Nuclear Engineering Division

    2010-05-25

    The activity of Phase I of the Waste Management Working Group under the United States - Japan Joint Nuclear Energy Action Plan started in 2007. The US-Japan JNEAP is a bilateral collaborative framework to support the global implementation of safe, secure, and sustainable, nuclear fuel cycles (referred to in this document as fuel cycles). The Waste Management Working Group was established by strong interest of both parties, which arise from the recognition that development and optimization of waste management and disposal system(s) are central issues of the present and future nuclear fuel cycles. This report summarizes the activity of the Waste Management Working Group that focused on consolidation of the existing technical basis between the U.S. and Japan and the joint development of a plan for future collaborative activities. Firstly, the political/regulatory frameworks related to nuclear fuel cycles in both countries were reviewed. The various advanced fuel cycle scenarios that have been considered in both countries were then surveyed and summarized. The working group established the working reference scenario for the future cooperative activity that corresponds to a fuel cycle scenario being considered both in Japan and the U.S. This working scenario involves transitioning from a once-through fuel cycle utilizing light water reactors to a one-pass uranium-plutonium fuel recycle in light water reactors to a combination of light water reactors and fast reactors with plutonium, uranium, and minor actinide recycle, ultimately concluding with multiple recycle passes primarily using fast reactors. Considering the scenario, current and future expected waste streams, treatment and inventory were discussed, and the relevant information was summarized. Second, the waste management/disposal system optimization was discussed. Repository system concepts were reviewed, repository design concepts for the various classifications of nuclear waste were summarized, and the factors

  15. Coalbed gas development

    SciTech Connect

    Not Available

    1992-01-01

    This book includes: Overview of coalbed gas development; Coalbed gas development in the West Coalbed gas development on Indian lands; Multi-mineral development conflicts; Statutory solutions to ownership disputes; State and local regulation; Environmental regulations; Status of the section 29 tax credit extension; Using the section 29 credit; Leasing coalbed gas prospects; Coalbed gas joint operating agreements and Purchase and sale agreements for coalbed gas properties.

  16. Yardang Development

    NASA Technical Reports Server (NTRS)

    2004-01-01

    the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  17. Biofilm development in a hotspot of mixing between shallow and deep groundwater in a fractured aquifer: field evidence from joint flow, chemical and microbiological characterization

    NASA Astrophysics Data System (ADS)

    Bochet, Olivier; Le Borgne, Tanguy; Pédrot, Mathieu; Labasque, Thierry; Lavenant, Nicolas; Petton, Christophe; Dufresne, Alexis; Ben Maamar, Sarah; Chatton, Eliot; De la Bernardie, Jérôme; Aquilina, Luc

    2015-04-01

    Biofilm development in a hotspot of mixing between shallow and deep groundwater in a fractured aquifer: field evidence from joint flow, chemical and microbiological characterization Olivier Bochet1, Tanguy Le Borgne1, Mathieu Pédrot1, Thierry Labasque1, Nicolas Lavenant1, Christophe Petton1, Alexis Dufresne2,Sarah Ben Maamar1-2, Eliot Chatton1, Jérôme de la Bernardie1, Luc Aquilina1 1: Géosciences Rennes, CNRS UMR 6118, Université de Rennes 1, Campus de Beaulieu bât 14B, Rennes, France 2: Ecobio, CNRS UMR 6553, Université de Rennes 1, Campus de Beaulieu, bât 14, Rennes, France Biofilms play a major role in controlling the fluxes and reactivity of chemical species transported in hydrological systems. Their development can have either positive impacts on groundwater quality (e.g. attenuation of contaminants under natural or stimulated conditions), or possible negative effects on subsurface operations (e.g. bio-clogging of geothermal dipoles or artificial recharge systems). Micro-organisms require both electron donors and electron acceptors for cellular growth, proliferation and maintenance of their metabolic functions. The mechanisms controlling these reactions derive from the interactions occurring at the micro-scale that depend on mineral compositions, the biota of subsurface environment, but also fluid mixing, which determines the local concentrations of nutriments, electron donors and electron acceptors. Hence, mixing zones between oxygen and nutriment rich shallow groundwater and mineralized deep groundwater are often considered as potential hotspots of microbial activity, although relatively few field data document flow distributions, transport properties, chemical gradients and micro-organisms distributions across these mixing interfaces. Here we investigate the origin of a localized biofilm development observed in the fractured granite aquifer at the Ploemeur observatory (H+ network hplus.ore.fr).This biofilm composed of ferro-oxidizing bacteria is

  18. Development of a mediated whole cell-based electrochemical biosensor for joint toxicity assessment of multi-pollutants using a mixed microbial consortium.

    PubMed

    Gao, Guanyue; Qian, Jun; Fang, Deyu; Yu, Yuan; Zhi, Jinfang

    2016-06-14

    Since most risk assessment for toxicants is based on individual single-species test, the deduction of such results to ecosystem evaluation is afflicted with uncertainties. Herein, we successfully developed a p-benzoquinone mediated whole-cell electrochemical biosensor for multi-pollutants toxicological analysis by co-immobilizing mixed strains of microorganism, including Escherichia coli (gram-negative bacteria), Bacillus subtilis (gram-positive bacteria) and Saccharomyces cerevisiae (fungus). The individual and combined toxicities of heavy metal ions (Cu(2+), Cd(2+)), phenol (3,5-dichlorophenol) and pesticides (Ametryn, Acephate) were examined. The experimental results showed that the order of toxicity for individual toxicant was ranked as Cu(2+) > 3,5-dichlorophenol (DCP) > Ametryn > Cd(2+) > Acephate. Then the toxic unit (TU) model was applied to determine the nature of toxicological interaction of the toxicants which can be classified as concentration additive (IC50mix = 1TU), synergistic (IC50mix < 1TU) and antagonistic (IC50mix > 1TU) responses. The binary combination of Cu(2+) + Cd(2+), Cu(2+) + DCP, Cu(2+) + Acephate, DCP + Acephate, Acephate + Ametryn were analyzed and the three kind of joint toxicity effects (i.e. additive, synergistic and antagonistic) mentioned above were observed according to the dose-response relationship. The results indicate that the whole-cell electrochemical biosensor based on mixed microbial consortium is more reasonable to reflect the joint biotoxicity of multi-pollutants existing in real wastewater, and combined effects of toxicants is extremely necessary to be taken into account in ecological risk assessment. Thus, present study has provided a promising approach to the quality assessment of wastewater and a reliable way for early risk warning of acute biotoxicity. PMID:27181640

  19. Child Development

    MedlinePlus

    ... content Start of Search Controls Search Form Controls Child Development Cancel Submit Search The CDC CDC A-Z ... Z # Start of Search Controls Search Form Controls Child Development Cancel Submit Search The CDC Child Development Note: ...

  20. Adolescent development

    MedlinePlus

    Development - adolescent; Growth and development - adolescent ... rights and privileges. Establish and maintain satisfying relationships. Adolescents will learn to share intimacy without feeling worried ...

  1. Child Development

    MedlinePlus

    As children grow older, they develop in several different ways. Child development includes physical, intellectual, social, and emotional changes. Children grow and mature at very different rates. It's ...

  2. Consumerism & Development.

    ERIC Educational Resources Information Center

    Ockenden, Sandy

    1991-01-01

    This material asks social studies students in Canada to recognize the implications of the lifestyles of citizens in developed countries, and the power that consumers have to create change for a better world, to be agents of positive development. Development is seen as a four faceted process. This model implies that development is an approach to…

  3. A Joint Workshop on Promoting the Development and Deployment of IGCC/Co-Production/CCS Technologies in China and the United States. Workshop report

    SciTech Connect

    Zhao, Lifeng; Ziao, Yunhan; Gallagher, Kelly Sims

    2009-06-03

    With both China and the United States relying heavily on coal for electricity, senior government officials from both countries have urged immediate action to push forward technology that would reduce carbon dioxide emissions from coal-fired plants. They discussed possible actions at a high-level workshop in April 2009 at the Harvard Kennedy School jointly sponsored by the Belfer Center's Energy Technology Innovation Policy (ETIP) research group, China's Ministry of Science and Technology, and the Chinese Academy of Sciences. The workshop examined issues surrounding Integrated Gasification Combined Cycle (IGCC) coal plants, which turn coal into gas and remove impurities before the coal is combusted, and the related carbon capture and sequestration, in which the carbon dioxide emissions are captured and stored underground to avoid releasing carbon dioxide into the atmosphere. Though promising, advanced coal technologies face steep financial and legal hurdles, and almost certainly will need sustained support from governments to develop the technology and move it to a point where its costs are low enough for widespread use.

  4. Fetal development

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002398.htm Fetal development To use the sharing features on this page, ... Cunningham FG, Leveno KJ, Bloom SL, et al. Fetal growth and development. In: Cunningham FG, Leveno KL, Bloom SL, et ...

  5. Toddler Development

    MedlinePlus

    ... developmental milestones. It is exciting to watch your toddler learn new skills. The normal development of children ... playing with others, taking turns, doing fantasy play Toddlers do not develop at the same rate. There ...

  6. Technology Development.

    ERIC Educational Resources Information Center

    Gomory, Ralph E.

    1983-01-01

    The evolutionary character and complexity of technological development is discussed, focusing on the steam engine and computer as examples. Additional topics include characteristics of science/technology, cultural factors in technological development, technology transfer, and problems in technological organization. (JN)

  7. Toddler development

    MedlinePlus

    Toddlers are children ages 1 - 3. CHILD DEVELOPMENT THEORIES Cognitive (thought) development skills typical for toddlers include: Early use of instruments or tools Following visual (then later, invisible) displacement (moving ...

  8. Child Development

    MedlinePlus

    ... grow older, they develop in several different ways. Child development includes physical, intellectual, social, and emotional changes. ... same sex. Peer approval becomes very important. Your child may try new behaviors to be part of " ...

  9. Sustainable Development.

    ERIC Educational Resources Information Center

    Auerbach, Raymond

    1994-01-01

    Discusses South African national development priorities, sustainable development, and the future of agriculture and presents three scenarios of possible national action: production for sale and export, household food security, and conservation of natural resources. (MKR)

  10. Developer Network

    Energy Science and Technology Software Center (ESTSC)

    2012-08-21

    NREL's Developer Network, developer.nrel.gov, provides data that users can access to provide data to their own analyses, mobile and web applications. Developers can retrieve the data through a Web services API (application programming interface). The Developer Network handles overhead of serving up web services such as key management, authentication, analytics, reporting, documentation standards, and throttling in a common architecture, while allowing web services and APIs to be maintained and managed independently.

  11. Teacher Development.

    ERIC Educational Resources Information Center

    1997

    Eight conference papers on language teacher development are presented, including: "Mosaics of Teacher Development and Socialization" (Andrew Barfield, Paul A. Beaufait, Sean Conley, Tim Murphey, Katsura Haruko), a panel presentation on aspects of and experiments in teacher development; "Questions About Teaching? Answers from Teachers!" (David…

  12. Career Development.

    ERIC Educational Resources Information Center

    1996

    This document consists of four papers presented during a symposium on career development moderated by David Bjorkquist at the 1996 conference of the Academy of Human Resource Development (AHRD). "A Mentoring Model for Career Development" (Mary Finnegan) describes a study that created a model based on the assumption that mentoring is an essential…

  13. Faculty Development.

    ERIC Educational Resources Information Center

    Gillan, Bob, Ed.; McFerrin, Karen, Ed.

    This document contains the following papers on faculty development and technology: "Involving Faculty in Faculty Development" (Kristine Blair and Dan Madigan); "Technology Use in Higher Education: A Faculty Development Model" (Jessica Kahn); "A Faculty of Education as a Community of Learners: Growing to Meet the Demands of Instruction and…

  14. Biofilm development in a hotspot of mixing between shallow and deep groundwater in a fractured aquifer: field evidence from joint flow, chemical and microbiological measurements

    NASA Astrophysics Data System (ADS)

    Bochet, O.; Dufresne, A.; Pédrot, M.; Chatton, E.; Labasque, T.; Ben Maamar, S.; Burté, L.; de la Bernardie, J.; Guihéneuf, N.; Lavenant, N.; Petton, C.; Bour, O.; Aquilina, L.; Le Borgne, T.

    2015-12-01

    Biofilms play a major role in controlling the fluxes and reactivity of chemical species transported in hydro-logical systems. Micro-organisms require both electron donors and electron acceptors for cellular growth, proliferation and maintenance of their metabolic functions. The mechanisms controlling these reactions derive from the interactions occurring at the micro-scale that depend on mineral compositions, the biota of subsurface environment, but also fluid mixing, which determines the local concentrations of nutriments, electron donors and electron acceptors. Hence, mixing zones between oxygen and nutriment rich shallow groundwater and mineralized deep groundwater are often considered as potential hotspots of microbial activity, although relatively few field data document flow distributions, transport properties, chemical gradients and micro-organisms distributions across these mixing interfaces. Here we investigate the origin of a localized biofilm development observed in the fractured granite aquifer at the Ploemeur observatory (H+ network hplus.ore.fr).This biofilm composed of ferro-oxidizing bacteria is observed in an 130m deep artesian well. Borehole video logs show an important colonization of the well by the biofilm in the shallower part (0 to 60m), while it is inexistent in the deeper part (60 to 130m). As flow is localized in a few deep and shallow fractures, we presume that the spatial distribution of biofilm is controlled by mixing between shallow and deep groundwater. To verify this hypothesis we conducted a field campaign with joint characterization of the flow and chemical composition of water flowing from the different fractures, as well as the microbiological composition of the biofilm at different depth, using pyrosequencing techniques. We will discuss in this presentation the results of this interdisciplinary dataset and their implications for the occurrence of hotspots of microbiological activity in the subsurface.

  15. Development of gait performance and dynamic hip and knee joint loading after containment improving surgery in patients with Legg-Calvé-Perthes disease.

    PubMed

    Stief, Felix; Schmidt, André; Adolf, Stefanie; Kremer, Laura; Brkic, Moamer; Meurer, Andrea

    2016-06-01

    Current surgery outcome evaluations in patients with Legg-Calvé-Perthes disease (LCPD) are usually based on static radiological changes. The aim of the present study was to assess the development of characteristic gait parameters and passive hip range of motion (ROM) measurements during the postoperative period up to healed stage of the femoral head represented by Stulberg classification. Twelve children (10 male, 2 female) with unilateral diagnosis of LCPD and 19 healthy control subjects at the same age participated in this prospective longitudinal study. Instrumented gait analysis was performed preoperatively, 13.4 (±1.7), and 28.0 (±4.4) months postoperatively. At final follow-up, the mean leg length of the involved side was reduced by 1.10 (±0.53)cm compared to the non-involved side. In addition, a significant reduction in maximum knee flexion (-26%, p=0.037) and knee flexion/extension ROM (-26%, p=0.017) in stance was still present in the patient group compared to controls indicating a "stiff knee gait pattern". In contrast, the sagittal plane hip parameters, the ipsilateral trunk lean toward the involved stance limb, and the knee and hip joint loading during gait normalized during the postoperative period. The results of the present study should motivate further exploration if patients with LCPD stiffen their knees to compensate for leg length discrepancy. Besides the standard radiological evaluation of the surgery outcome, instrumented gait analysis is a valuable method of recording functional deficits and early recognition of the need for physiotherapeutic treatment or insole supply in patients with LCPD. PMID:27264403

  16. Validation of hip joint center localization methods during gait analysis using 3D EOS imaging in typically developing and cerebral palsy children.

    PubMed

    Assi, Ayman; Sauret, Christophe; Massaad, Abir; Bakouny, Ziad; Pillet, Hélène; Skalli, Wafa; Ghanem, Ismat

    2016-07-01

    Localization of the hip joint center (HJC) is essential in computation of gait data. EOS low dose biplanar X-rays have been shown to be a good reference in evaluating various methods of HJC localization in adults. The aim is to evaluate predictive and functional techniques for HJC localization in typically developing (TD) and cerebral palsy (CP) children, using EOS as an image based reference. Eleven TD and 17 CP children underwent 3D gait analysis. Six HJC localization methods were evaluated in each group bilaterally: 3 predictive (Plug in Gait, Bell and Harrington) and 3 functional methods based on the star arc technique (symmetrical center of rotation estimate, center transformation technique and geometrical sphere fitting). All children then underwent EOS low dose biplanar radiographs. Pelvis, lower limbs and their corresponding external markers were reconstructed in 3D. The center of the femoral head was considered as the reference (HJCEOS). Euclidean distances between HJCs estimated by each of the 6 methods and the HJCEOS were calculated; distances were shown to be lower in predictive compared to functional methods (p<0.0001). Contrarily to findings in adults, functional methods were shown to be less accurate than predictive methods in TD and CP children, which could be mainly due to the shorter thigh segment in children. Harrington method was shown to be the most accurate in the prediction of HJC (mean error≈18mm, SD=9mm) and quasi-equivalent to the Bell method. The bias for each method was quantified, allowing its correction for an improved HJC estimation. PMID:27477704

  17. Neurovascular development

    PubMed Central

    James, Jennifer M

    2009-01-01

    Neurovascular development in the central nervous system has a rich history and compelling significance. The developing central nervous system (CNS) does not produce vascular progenitor cells, and so ingression of blood vessels is required for continued CNS development and function. Classic studies provide elegant descriptions of formation of the vascular plexus that surrounds the embryonic brain and spinal cord, and the subsequent ingression of blood vessels into the neural tissue. Recent work has focused on the molecular pathways responsible for neurovascular cross-talk and development of the blood-brain barrier. Here we review neurovascular development in the central nervous system, with emphasis on the spinal cord. We discuss the historical work, the current status of our knowledge and unanswered questions. The importance of neurovascular development to diseases of the cerebral vasculature and the neural stem cell niche are discussed. PMID:19363295

  18. Program Development

    SciTech Connect

    Atencio, Julian J.

    2014-05-01

    This presentation covers how to go about developing a human reliability program. In particular, it touches on conceptual thinking, raising awareness in an organization, the actions that go into developing a plan. It emphasizes evaluating all positions, eliminating positions from the pool due to mitigating factors, and keeping the process transparent. It lists components of the process and objectives in process development. It also touches on the role of leadership and the necessity for audit.

  19. KENO developments

    SciTech Connect

    Hollenbach, D.F.; Landers, N.F.; Petrie, L.M.

    1997-06-01

    Modifications and developments to the series of KENO multigroup, criticality safety transport codes are very briefly summarized. Three areas are addressed: (1) modifications to KENO-V.a, (2) development of KENO-VI, (3) modifications to the CSAS4 sequence of the SCALE package, and (4) future work on KENO related programs. Minor changes have been made to KENO-V.a, primarily for maintenance. KENO-VI has been developed and will be released soon. A new search type is being developed in SCALE to allow CSAS4 to do a concentration search on a mixture component.

  20. Developable resources

    SciTech Connect

    Hunt, R.T.; Hunt, J.M.

    1995-01-01

    In the United States, it has become the conventional wisdom that all developable conventional hydropower resources have been exhausted. Studies by the US Department of Energy (DOE) and other agencies find differently. The root of disagreement may lie in the definition of what is developable. Environmental special interest groups now define developable hydropower sites as those having zero effect on the environment. As a result they conclude there are no additional developable hydropower sites. By contrast, the definition used by DOE and others is broader as it balances economic, technical, and environmental factors in accordance with the Federal Power Act.

  1. Power assist EVA glove development

    NASA Technical Reports Server (NTRS)

    Main, John A.; Peterson, Steven W.; Strauss, Alvin M.

    1992-01-01

    The design of the EVA glove is examined, emphasizing the development of a more flexible metacarpophalangeal (MCP) joint for the EVA glove. The analysis of the EVA glove MCP joint is reviewed and the glove design process is recapitulated. Experimental tests of the glove are summarized.

  2. Collection Development.

    ERIC Educational Resources Information Center

    School Libraries in Canada, 2002

    2002-01-01

    Includes 21 articles that discuss collection development in Canadian school libraries. Topics include digital collections in school library media centers; print and electronic library resources; library collections; collaborative projects; print-disabled students; informing administrators of the importance of collection development; censorship;…

  3. Management Development.

    ERIC Educational Resources Information Center

    1997

    This document contains three papers from a symposium on management development. "LMX (Leader-Member Exchange) Theory, Personality Type, and Management Development" (Janet Z. Burns) reports the results of a study on the similarities and differences in personality type (as outlined in the theories of Carl Jung and Isabel Myers) and its relationship…

  4. Numerical Development

    ERIC Educational Resources Information Center

    Siegler, Robert S.; Braithwaite, David W.

    2016-01-01

    In this review, we attempt to integrate two crucial aspects of numerical development: learning the magnitudes of individual numbers and learning arithmetic. Numerical magnitude development involves gaining increasingly precise knowledge of increasing ranges and types of numbers: from non-symbolic to small symbolic numbers, from smaller to larger…

  5. Staff Development.

    ERIC Educational Resources Information Center

    Reusswig, James, Ed.; Ponzio, Richard, Ed.

    1980-01-01

    Eight essays are presented which reflect current problems, issues, and practices related to the development of teacher and administrator expertise. The authors are school district and public school administrators, faculty of schools of education, and a director of staff development in a state department of education. The topics treated are: (1)…

  6. Professional Development.

    ERIC Educational Resources Information Center

    Benson, Chris, Ed.

    2000-01-01

    This serial issue contains 12 articles on the theme of "Professional Development," specifically about how teachers in the Bread Loaf Rural Teacher Network (BLRTN) are fostering their own and each other's development as teachers. The BLRTN consists of approximately 260 rural teachers in Alaska, Arizona, Colorado, Georgia, Kentucky, Mississippi, New…

  7. [Toddler Development.

    ERIC Educational Resources Information Center

    Pawl, Jeree, Ed.

    1991-01-01

    This theme newsletter issue presents seven articles describing toddler behavior and development, services for toddlers, and toddlers with special needs. The first article, "Toddlers: Themes and Variations" (Lois Barclay Murphy and Colleen Small) focuses on variations in toddler development, noting emerging skills, language, and the caregiver role.…

  8. Determinations of PCB within a project to develop cleanup methods for PCB-containing elastic sealant used in outdoor joints between concrete blocks in buildings.

    PubMed

    Sundahl, M; Sikander, E; Ek-Olausson, B; Hjorthage, A; Rosell, L; Tornevall, M

    1999-08-01

    Determinations of PCB were carried out as part of a project aimed at developing cleanup methods for PCB-containing elastic sealant used in outdoor joints between concrete blocks. The goals of the project were to develop methods, which minimise the spread of PCB to the outdoor environment and to indoor air, and which keep the PCB levels as low as reasonably possible in the workplace environment whilst removing the elastic sealant. The following PCB determinations were carried out: (1) concentration in the elastic sealant; (2) concentration in the concrete close to the sealant; (3) concentration in soil; (4) concentration in the indoor air; and (5) concentration in the air in the workplace environment. The cleanup process consisted of a number of different steps: (1) cutting the elastic sealant with an oscillating knife; (2) grinding the concrete with a mechanical machine; (3) sawing the concrete with a mechanical saw and (4) cutting the concrete with a mechanical chisel. In all these different steps a high capacity vacuum cleaner connected to the machines was used. The elastic sealant contained 4.7 to 8.1% total PCB of a technical product with a composition most similar to Clophene A40. The concrete close to the sealant (first 2 mm) contained 0.12 and 1.7% total PCB at two different places. The pattern of the PCB in the concrete resembled that of the sealant. PCB concentrations in the soil from the ground close to the building were 0.1 and 0.3 ppm at two different places before the remedial action. The source of the PCB in the soil is most likely the sealant as the PCB pattern is similar for the two materials. The PCB levels in the workplace air at the beginning of the project, when the techniques were not fully developed, were generally above the occupational exposure limit of 10 micrograms m-3 (up to 120 micrograms m-3). Later when the techniques were optimised to better take care of dust and gases produced during the cutting and grinding etc., the levels were

  9. Technology development.

    PubMed

    Gomory, R E

    1983-05-01

    In technology development significant advances are as often the result of a series of evolutionary steps as they are of breakthroughs. This is illustrated by the examples of the steam engine and the computer. Breakthroughs, such as the transistor, are relatively rare, and are often the result of the introduction of new knowledge coming from a quite different area. Technology development is often difficult to predict because of its complexity; practical considerations may far outweigh apparent scientific advantages, and cultural factors enter in at many levels. In a large technological organization problems exist in bringing scientific knowledge to bear on development, but much can be done to obviate these difficulties. PMID:17749515

  10. Sustainable developments

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    Hundreds of diplomats, along with industry, finance, environment, and labor leaders from around the world met from April 20 to May 1 for the sixth session of the United Nations Commission for Sustainable Development (CSD), an annual follow-up conference to track the Agenda 21 program of action adopted at the 1992 Rio de Janeiro Earth Summit.During the session, which focused on freshwater management concerns and the role of industry in sustainable development, the participants discussed a number of issues about development and parity among northern and southern hemisphere countries.

  11. Eye development.

    PubMed

    Baker, Nicholas E; Li, Ke; Quiquand, Manon; Ruggiero, Robert; Wang, Lan-Hsin

    2014-06-15

    The eye has been one of the most intensively studied organs in Drosophila. The wealth of knowledge about its development, as well as the reagents that have been developed, and the fact that the eye is dispensable for survival, also make the eye suitable for genetic interaction studies and genetic screens. This article provides a brief overview of the methods developed to image and probe eye development at multiple developmental stages, including live imaging, immunostaining of fixed tissues, in situ hybridizations, and scanning electron microscopy and color photography of adult eyes. Also summarized are genetic approaches that can be performed in the eye, including mosaic analysis and conditional mutation, gene misexpression and knockdown, and forward genetic and modifier screens. PMID:24784530

  12. Toddler Development

    MedlinePlus

    ... is exciting to watch your toddler learn new skills. The normal development of children aged 1-3 can be broken down into the following areas: Gross motor - walking, running, climbing Fine motor - feeding themselves, drawing Sensory - seeing, hearing, tasting, ...

  13. Brain Development

    MedlinePlus

    ... new neural connections every second. This growing brain development is influenced by many factors, including a child’s relationships, experiences and environment. Learn more about the crucial role you play ...

  14. EYE DEVELOPMENT

    PubMed Central

    Baker, Nicholas E.; Li, Ke; Quiquand, Manon; Ruggiero, Robert; Wang, Lan-Hsin

    2014-01-01

    The eye has been one of the most intensively studied organs in Drosophila. The wealth of knowledge about its development, as well as the reagents that have been developed, and the fact that the eye is dispensable for survival, also make the eye suitable for genetic interaction studies and genetic screens. This chapter provides a brief overview of the methods developed to image and probe eye development at multiple developmental stages, including live imaging, immunostaining of fixed tissues, in situ hybridizations, and scanning electron microscopy and color photography of adult eyes. Also summarized are genetic approaches that can be performed in the eye, including mosaic analysis and conditional mutation, gene misexpression and knockdown, and forward genetic and modifier screens. PMID:24784530

  15. Speech Development

    MedlinePlus

    ... W View More… Donate Donor Spotlight Fundraising Ideas Vehicle Donation Volunteer Efforts Speech Development skip to submenu ... Lip and Palate . Bzoch (1997). Cleft Palate Speech Management: A Multidisciplinary Approach . Shprintzen, Bardach (1995). Cleft Palate: ...

  16. Leaf Development

    PubMed Central

    2013-01-01

    Leaves are the most important organs for plants. Without leaves, plants cannot capture light energy or synthesize organic compounds via photosynthesis. Without leaves, plants would be unable perceive diverse environmental conditions, particularly those relating to light quality/quantity. Without leaves, plants would not be able to flower because all floral organs are modified leaves. Arabidopsis thaliana is a good model system for analyzing mechanisms of eudicotyledonous, simple-leaf development. The first section of this review provides a brief history of studies on development in Arabidopsis leaves. This history largely coincides with a general history of advancement in understanding of the genetic mechanisms operating during simple-leaf development in angiosperms. In the second section, I outline events in Arabidopsis leaf development, with emphasis on genetic controls. Current knowledge of six important components in these developmental events is summarized in detail, followed by concluding remarks and perspectives. PMID:23864837

  17. Teen Development

    MedlinePlus

    ... 12 and 16 for boys. As your body changes, you may have questions about sexual health. During this time, you start to develop your own unique personality and opinions. Some changes that you might notice include Increased independence from ...

  18. Development risks

    SciTech Connect

    Riedy, M.; Desai, S.

    1996-04-01

    Risks associated with hydropower production development in India are discussed in this article. A project prospectus for the development of India`s estimated 84,044 MW(e) hydropower potential is given which accounts for environmental and regulatory concerns. Regulations issued by the Government of Industry regarding private investment in hydropower are outlined, and additional policies which are expected to be instituted are discussed.

  19. Clean development mechanism: Perspectives from developing countries

    SciTech Connect

    Sari, Agus P.; Meyers, Stephen

    1999-06-01

    This paper addresses the political acceptability and workability of CDM by and in developing countries. At COP-3 in Kyoto in 1997, the general position among developing countries changed from strong rejection of joint implementation to acceptance of CDM. The outgrowth of CDM from a proposal from Brazil to establish a Clean Development Fund gave developing countries a sense of ownership of the idea. More importantly, establishing support for sustainable development as a main goal for CDM overcame the resistance of many developing countries to accept a carbon trading mechanism. The official acceptance of CDM is not a guarantee of continued acceptance, however. Many developing countries expect CDM to facilitate a substantial transfer of technology and other resources to support economic growth. There is concern that Annex I countries may shift official development assistance into CDM in order to gain carbon credits, and that development priorities could suffer as a result. Some fear that private investments could be skewed toward projects that yield carbon credits. Developing country governments are wary regarding the strong role of the private sector envisioned for CDM. Increasing the awareness and capacity of the private sector in developing countries to initiate and implement CDM projects needs to be a high priority. While private sector partnerships will be the main vehicle for resource transfer in CDM, developing country governments want to play a strong role in overseeing and guiding the process so that it best serves their development goals. Most countries feel that establishment of criteria for sustainable development should be left to individual countries. A key issue is how CDM can best support the strengthening of local capacity to sustain and replicate projects that serve both climate change mitigation and sustainable development objectives.There is support among developing countries for commencing CDM as soon as possible. Since official commencement must

  20. The Joint Space Operations Center (JSpOC) Mission System (JMS) and the Advanced Research, Collaboration, and Application Development Environment (ARCADE)

    NASA Astrophysics Data System (ADS)

    Runco, A.; Echeverry, J.; Kim, R.; Sabol, C.; Zetocha, P.; Murray-Krezan, J.

    2014-09-01

    The JSpOC Mission System is a modern service-oriented architecture (SOA) infrastructure with increased process automation and improved tools to enhance Space Situational Awareness (SSA). The JMS program has already delivered Increment 1 in April 2013 as initial capability to operations. The programs current focus, Increment 2, will be completed by 2016 and replace the legacy Space Defense Operations Center (SPADOC) and Astrodynamics Support Workstation (ASW) capabilities. Post 2016, JMS Increment 3 will continue to provide additional SSA and C2 capabilities that will require development of new applications and procedures as well as the exploitation of new data sources with more agility. In 2012, the JMS Program Office entered into a partnership with AFRL/RD (Directed Energy) and AFRL/RV (Space Vehicles) to create the Advanced Research, Collaboration, and Application Development Environment (ARCADE). The purpose of the ARCADE is to: (1) serve as a centralized testbed for all research and development (R&D) activities related to JMS applications, including algorithm development, data source exposure, service orchestration, and software services, and provide developers reciprocal access to relevant tools and data to accelerate technology development, (2) allow the JMS program to communicate user capability priorities and requirements to developers, (3) provide the JMS program with access to state-of-the-art research, development, and computing capabilities, and (4) support market research efforts by identifying outstanding performers that are available to shepherd into the formal transition process. AFRL/RV and AFRL/RD have created development environments at both unclassified and classified levels that together allow developers to develop applications and work with data sources. The unclassified ARCADE utilizes the Maui high performance computing (HPC) Portal, and can be accessed using a CAC or Kerberos using Yubikey. This environment gives developers a sandbox

  1. Sustainable development is healthy development.

    PubMed

    Litsios, S

    1994-01-01

    Economic growth has brought with it substantial environmental damage. Nature has been abused and little consideration has been given to the consequences, among them the adverse effects on health. Healthy people are vital for local development that is both economically and ecologically sound. The health sector should be actively involved in the movement for sustainable development. What this would require in practice is considered below, with particular reference to the quality of life in regions of tropical forest. PMID:8018295

  2. Normal development.

    PubMed

    Girard, Nadine; Koob, Meriam; Brunel, Herv

    2016-01-01

    Numerous events are involved in brain development, some of which are detected by neuroimaging. Major changes in brain morphology are depicted by brain imaging during the fetal period while changes in brain composition can be demonstrated in both pre- and postnatal periods. Although ultrasonography and computed tomography can show changes in brain morphology, these techniques are insensitive to myelination that is one of the most important events occurring during brain maturation. Magnetic resonance imaging (MRI) is therefore the method of choice to evaluate brain maturation. MRI also gives insight into the microstructure of brain tissue through diffusion-weighted imaging and diffusion tensor imaging. Metabolic changes are also part of brain maturation and are assessed by proton magnetic resonance spectroscopy. Understanding and knowledge of the different steps in brain development are required to be able to detect morphologic and structural changes on neuroimaging. Consequently alterations in normal development can be depicted. PMID:27430460

  3. Sustainable Development

    NASA Astrophysics Data System (ADS)

    Schmandt, Jurgen; Ward, C. H.; Marilu Hastings, Assisted By

    2000-04-01

    Demographers predict that the world population will double during the first half of the 21st century before it will begin to level off. In this volume, a group of prominent authors examine what societal changes must occur to meet this challenge to the natural environment and the transformational changes that we must experience to achieve sustainability. Frances Cairncross, Herman E. Daly, Stephen H. Schneider and others provide a broad discussion of sustainable development. They detail economic and environmental, as well as spiritual and religious, corporate and social, scientific and political factors. Sustainable Development: The Challenge of Transition offers many insightful policy recommendations about how business, government, and individuals must change their current values, priorities, and behavior to meet present and future challenges. It will appeal to scholars and decision makers interested in global change, environmental policy, population growth, and sustainable development, and also to corporate environmental managers.

  4. Development of a superconducting joint between a GdBa2Cu3O7-δ-coated conductor and YBa2Cu3O7-δ bulk: towards a superconducting joint between RE (Rare Earth) Ba2Cu3O7-δ-coated conductors

    NASA Astrophysics Data System (ADS)

    Jin, Xinzhe; Yanagisawa, Yoshinori; Maeda, Hideaki; Takano, Yoshiki

    2015-07-01

    We have started to develop a superconducting bridge joint between two GdBa2Cu3O7-δ (Gd123)-coated conductors, where both conductors are placed in an end-to-end arrangement on the surface of a melt-textured YBCO (including Y2BaCuO5 and YBa2Cu3O7-δ) bulk, which acts as a superconducting medium between the coated conductors. As a first step in the development, one half of the bridge joint assembly was modeled and investigated. Experimental results achieved are as follows: (a) the higher-melting-temperature textured Gd123-coated conductor acts as a seed for the melt texture of the YBa2Cu3O7-δ (Y123) bulk, and (b) the superconducting phase continues across the Y123/Gd123 boundary. The critical current of the joint model is 10 A, which is about 10% of the original Gd123-coated conductor, at 77 K in a self-magnetic field. These results are considered to be extensible to the superconducting bridge joint between the Gd123-coated conductors.

  5. Defining "Development".

    PubMed

    Pradeu, Thomas; Laplane, Lucie; Prévot, Karine; Hoquet, Thierry; Reynaud, Valentine; Fusco, Giuseppe; Minelli, Alessandro; Orgogozo, Virginie; Vervoort, Michel

    2016-01-01

    Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined biological, philosophical, and historical approach, we ask whether it is possible and useful to define biological development, and, if such a definition is indeed possible and useful, which definition(s) can be considered as the most satisfactory. PMID:26969977

  6. Algorithm development

    NASA Technical Reports Server (NTRS)

    Barth, Timothy J.; Lomax, Harvard

    1987-01-01

    The past decade has seen considerable activity in algorithm development for the Navier-Stokes equations. This has resulted in a wide variety of useful new techniques. Some examples for the numerical solution of the Navier-Stokes equations are presented, divided into two parts. One is devoted to the incompressible Navier-Stokes equations, and the other to the compressible form.

  7. Interorganizational Development.

    ERIC Educational Resources Information Center

    Schermerhorn, John R., Jr.

    1979-01-01

    Interorganizational development is the application of social science knowledge to the creation of planned, systematic and mutually beneficial cooperative relationships between otherwise autonomous organizations. This paper introduces the concept as a means of focusing attention on key action and research issues associated with interorganizational…

  8. Gender Development.

    ERIC Educational Resources Information Center

    Golombok, Susan; Fivush, Robyn

    In spite of the loosening ties between reproductive and social roles, the worlds of men and women and boys and girls, are clearly not the same. There is much more to being female or male than the potential to mother or father a child. Gender development does not simply depend on children's relationship with their parents: it results from a complex…

  9. Workforce Development.

    ERIC Educational Resources Information Center

    1999

    This document contains four symposium papers on work force development. "Effects of Two Different Learning Paths on School-to-Work Transition" (Esther Van Der Schoot) discusses a Dutch study documenting that the following items make a difference in the school-to-work transition: learning path, curriculum characteristics, individual…

  10. Contraceptive Development.

    ERIC Educational Resources Information Center

    Troen, Philip; And Others

    This report provides an overview of research activities and needs in the area of contraceptive development. In a review of the present state, discussions are offered on the effectiveness and drawbacks of oral contraceptives, intrauterine devices, barrier methods, natural family planning, and sterilization. Methods of contraception that are in the…

  11. Developing ADHD

    ERIC Educational Resources Information Center

    Taylor, Eric

    2009-01-01

    Over the past 50 years the concept of attention deficit/hyperactivity disorder (ADHD) has developed from the notion of a specific form of brain dysfunction to that of a heterogeneous set of related behaviours. The great advances in genetics, neuroimaging and neuropsychiatry have made it one of the best understood forms of complex mental…

  12. Gender Development

    ERIC Educational Resources Information Center

    Owen Blakemore, Judith E.; Berenbaum, Sheri A.; Liben, Lynn S.

    2008-01-01

    This new text offers a unique developmental focus on gender. Gender development is examined from infancy through adolescence, integrating biological, socialization, and cognitive perspectives. The book's current empirical focus is complemented by a lively and readable style that includes anecdotes about children's everyday experiences. The book's…

  13. New Developments

    ERIC Educational Resources Information Center

    Lohmander, Maelis Karlsson, Ed.; Rabusicova, Milada; Einarsdottir, Johanna

    2008-01-01

    The development of early childhood education (ECE) in Europe and beyond is inextricably linked with women's roles and power in society. Towards the end of the nineteenth and beginning of the twentieth century in a context of urbanisation and industrialisation the need for some sort of public childcare became apparent in many countries. Whereas…

  14. Trends Developments.

    ERIC Educational Resources Information Center

    ASPBAE Courier Service, 1981

    1981-01-01

    This issue contains extracts from twenty-one country reports and case studies presented to the Unesco Regional Seminar on Adult Education and Development in Bangkok, November 24-December 4, 1980. The excerpts have an emphasis on innovations in adult education in the region. Countries and programs discussed include (1) community…

  15. CAREER DEVELOPMENT

    EPA Science Inventory

    The Baltimore Summit Project on Career Development/PERFORMS Enhancement/360 Evaluations for All has made some progress. We have identified the fact that we cannot change the current Pass/Fail PERFORMS system to a tiered system. The current pass/fail system does not have a mechani...

  16. Envisioning Development

    ERIC Educational Resources Information Center

    Dealtry, Richard

    2004-01-01

    This paper focuses on an important innovative development in new generation corporate university management. It addresses the thematic area of visual learning that is captured in the term "The Art of Minds-eye Management". It reflects upon experiences with groups of managers in enhancing perceptive competencies using visual awareness learning…

  17. Marker development

    SciTech Connect

    Adams, M.R.

    1987-05-01

    This report is to discuss the marker development for radioactive waste disposal sites. The markers must be designed to last 10,000 years, and place no undue burdens on the future generations. Barriers cannot be constructed that preclude human intrusion. Design specifications for surface markers will be discussed, also marker pictograms will also be covered.

  18. Fetal development

    MedlinePlus

    Cunningham FG, Leveno KJ, Bloom SL, et al. Fetal growth and development. In: Cunningham FG, Leveno KL, Bloom SL, et al, eds. Williams Obstetrics . 23rd ed. New York, NY: McGraw-Hill; ... and fetal physiology. In: Gabbe SG, Niebyl JR, Simpson JL, ...

  19. Flower Development

    PubMed Central

    Alvarez-Buylla, Elena R.; Benítez, Mariana; Corvera-Poiré, Adriana; Chaos Cador, Álvaro; de Folter, Stefan; Gamboa de Buen, Alicia; Garay-Arroyo, Adriana; García-Ponce, Berenice; Jaimes-Miranda, Fabiola; Pérez-Ruiz, Rigoberto V.; Piñeyro-Nelson, Alma; Sánchez-Corrales, Yara E.

    2010-01-01

    Flowers are the most complex structures of plants. Studies of Arabidopsis thaliana, which has typical eudicot flowers, have been fundamental in advancing the structural and molecular understanding of flower development. The main processes and stages of Arabidopsis flower development are summarized to provide a framework in which to interpret the detailed molecular genetic studies of genes assigned functions during flower development and is extended to recent genomics studies uncovering the key regulatory modules involved. Computational models have been used to study the concerted action and dynamics of the gene regulatory module that underlies patterning of the Arabidopsis inflorescence meristem and specification of the primordial cell types during early stages of flower development. This includes the gene combinations that specify sepal, petal, stamen and carpel identity, and genes that interact with them. As a dynamic gene regulatory network this module has been shown to converge to stable multigenic profiles that depend upon the overall network topology and are thus robust, which can explain the canalization of flower organ determination and the overall conservation of the basic flower plan among eudicots. Comparative and evolutionary approaches derived from Arabidopsis studies pave the way to studying the molecular basis of diverse floral morphologies. PMID:22303253

  20. New Developments

    ERIC Educational Resources Information Center

    Lohmander, Maelis Karlson; Vandenbroeck, Michel; Pirard, Florence; Peeters, Jan; Alvestad, Marit

    2009-01-01

    New developments and challenges regarding early childhood education (ECE) policy and practice in Norway and in the Flemish and French communities in Belgium are presented in this issue. There are clear differences between the countries when comparing systems they have chosen for ECE. In Belgium, supervision and responsibilities for education,…

  1. Professional Development.

    ERIC Educational Resources Information Center

    Inouye, Patricia C.; And Others

    A Liaison Committee at the University of California-Davis' library studied the concept of professional development, including the individual librarian's responsibility and the General Library's role in assisting its librarians. This document enumerates the committee's recommendations and outlines (1) the factors which influence the extent of a…

  2. Oh, Develop

    NASA Technical Reports Server (NTRS)

    Post, Todd

    2003-01-01

    In a mature view of the subject, career development is not simply four years of college or a week at training, culminating in a diploma or a certificate to hang on an office wall. That's why we wanted to take a broad look at career development in this issue of ASK. Take for example, Dr. Gerald Mulenburg s contribution, Fly on the Wall. When Mulenburg and other members of a knowledge-sharing group at Ames were invited to observe an upcoming project review, Mulenburg thought it would be interesting to learn how another project does its reviews. Note that Mulenburg is no fresh out who's never attended a NASA project review. Not only has he been through a fair share of them as the reviewed, he has also been on the other side of the table as a reviewer. This experienced project manager recognizes that at any stage of a career there is room to grow and develop one's repertoire. Too often people associate career development with textbooks and role classroom training, far removed from project life. But classroom training need not be like this, as you'll find in our Special Feature, The Enterprise Project by Wendy Dolci, which sprung out of an APPL Advanced Project Management class in July 2003 at Ames Research Center. In addition to Dolci, some of her classmates contribute to the story. Mike Sander of the Jet Propulsion Laboratory, project manager for the Mars Science Laboratory mission, who provided the assignment on which the story is based, also has a cameo in the story. We think Dolci's story is an inspiring example of what classroom training can be if it's approached imaginatively and made to serve a practical purpose. Another story from Ames, by Frank Larsen, takes a different twist on career development. At the annual Experimental Aircraft Association Fly-in in Oshkosh, Wisconsin, Larsen represented Ames at a NASA booth. While there, Larsen met a colleague from Glenn Research Center. Months later on a project with a quick turnaround, he remembered his colleague from

  3. Development and optimization of a high-throughput micro-computed tomography imaging method incorporating a novel analysis technique to evaluate bone mineral density of arthritic joints in a rodent model of collagen induced arthritis.

    PubMed

    Sevilla, Raquel S; Cruz, Francisco; Chiu, Chi-Sung; Xue, Dahai; Bettano, Kimberly A; Zhu, Joe; Chakravarthy, Kalyan; Faltus, Robert; Wang, Shubing; Vanko, Amy; Robinson, Gain; Zielstorff, Mark; Miao, John; Leccese, Erica; Conway, Donald; Moy, Lily Y; Dogdas, Belma; Cicmil, Milenko; Zhang, Weisheng

    2015-04-01

    Rheumatoid arthritis (RA) is a chronic autoimmune disease resulting in joint inflammation, pain, and eventual bone loss. Bone loss and remodeling caused by symmetric polyarthritis, the hallmark of RA, is readily detectable by bone mineral density (BMD) measurement using micro-CT. Abnormalities in these measurements over time reflect the underlying pathophysiology of the bone. To evaluate the efficacy of anti-rheumatic agents in animal models of arthritis, we developed a high throughput knee and ankle joint imaging assay to measure BMD as a translational biomarker. A bone sample holder was custom designed for micro-CT scanning, which significantly increased assay throughput. Batch processing 3-dimensional image reconstruction, followed by automated image cropping, significantly reduced image processing time. In addition, we developed a novel, automated image analysis method to measure BMD and bone volume of knee and ankle joints. These improvements significantly increased the throughput of ex vivo bone sample analysis, reducing data turnaround from 5 days to 24 hours for a study with 200 rat hind limbs. Taken together, our data demonstrate that BMD, as quantified by micro-CT, is a robust efficacy biomarker with a high degree of sensitivity. Our innovative approach toward evaluation of BMD using optimized image acquisition and novel image processing techniques in preclinical models of RA enables high throughput assessment of anti-rheumatic agents offering a powerful tool for drug discovery. PMID:25482211

  4. Adaptive Development

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The goal of this research is to develop and demonstrate innovative adaptive seal technologies that can lead to dramatic improvements in engine performance, life, range, and emissions, and enhance operability for next generation gas turbine engines. This work is concentrated on the development of self-adaptive clearance control systems for gas turbine engines. Researchers have targeted the high-pressure turbine (HPT) blade tip seal location for following reasons: Current active clearance control (ACC) systems (e.g., thermal case-cooling schemes) cannot respond to blade tip clearance changes due to mechanical, thermal, and aerodynamic loads. As such they are prone to wear due to the required tight running clearances during operation. Blade tip seal wear (increased clearances) reduces engine efficiency, performance, and service life. Adaptive sealing technology research has inherent impact on all envisioned 21st century propulsion systems (e.g. distributed vectored, hybrid and electric drive propulsion concepts).

  5. Polarization developments

    SciTech Connect

    Prescott, C.Y.

    1993-07-01

    Recent developments in laser-driven photoemission sources of polarized electrons have made prospects for highly polarized electron beams in a future linear collider very promising. This talk discusses the experiences with the SLC polarized electron source, the recent progress with research into gallium arsenide and strained gallium arsenide as a photocathode material, and the suitability of these cathode materials for a future linear collider based on the parameters of the several linear collider designs that exist.

  6. REGIONAL MANUFACTURING TECHNICAL DEVELOPMENT

    SciTech Connect

    EASON, H.A.

    1997-02-21

    This project covers four CRADAS (Cooperative Research and Development Agreements) which were initiated in 1991 and 1993. The two CRADAS with the state of Tennessee and the state of Florida were to provide technical assistance to small manufacturers in those states and the CRADA with the Tennessee Technology Foundation was to engage in joint economic development activities within the state. These three CRADAS do not fit the traditional definition of CRADAS and would be administered by other agreement mechanisms, today. But in these early days of technology transfer efforts, the CRADA mechanism was already developed and usable. The CRADA with Coors Ceramics is a good example of a CRADA and was used to develop nondestructive testing technology for ceramic component inspection. The report describes the background of this project, its economic impact, and its benefits to the U. S. Department of Energy.

  7. Illuminating Development

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Through the support of the NASA SBIR program, Control Vision, Inc. developed novel video techniques for clear, high resolution, real-time imaging of high temperature, high-energy industrial processes, such as welding, plasma arc spraying (coating), arc furnaces, metal casting and refractories (ceramics) melting. The Control Vision systems use reflected laser or strobe illumination, combined with ultra-short exposure times to create video, including the allowance of particle imaging velocimetry (PIV) of fast moving powder particles buried within a plasma stream.

  8. Professional development

    NASA Astrophysics Data System (ADS)

    Yoon, Jin Hee; Hartline, Beverly Karplus; Milner-Bolotin, Marina

    2013-03-01

    The three sessions of the professional development workshop series were each designed for a different audience. The purpose of the first session was to help mid-career physicists aspire for and achieve leadership roles. The second session brought together students, postdoctoral fellows, and early-career physicists to help them plan their career goals and navigate the steps important to launching a successful career. The final session sought to increase awareness of the results of physics education research, and how to use them to help students-especially women-learn physics better. The presentations and discussions were valuable for both female and male physicists.

  9. Pubertal Development and Prepubertal Height and Weight Jointly Predict Young Adult Height and Body Mass Index in a Prospective Study in South Africa12

    PubMed Central

    Martorell, Reynaldo; Richter, Linda M

    2016-01-01

    Background: Height and adiposity track over childhood, but few studies, to our knowledge, have longitudinally examined the mediating relation of the timing and progression of puberty. Objective: We assessed interrelations between prepubertal height and body mass index, the progression through puberty, and young adult height and adiposity. Methods: We analyzed data from the Birth to Twenty Plus study (females, n = 823; males, n = 765). Serial measures of anthropometry and pubertal development were obtained between ages 9 and 16 y. We used latent class growth analysis to categorize pubertal development with respect to pubic hair (females and males), breasts (females), and genitalia (males) development. Adult height and weight were obtained at ages 18 to 20 y. Results: Among females, higher latent class (earlier initiation and faster progression through puberty) was associated with an increased risk of obesity [pubic hair class 3 compared with class 1: RR, 3.41 (95% CI: 1.57, 7.44)] and inconsistent associations with height. Among males, higher latent class was associated with increased adult height [pubic hair development class 3 compared with class 1: 2.43 cm (95% CI: 0.88, 4.00)] and increased risk of overweight/obesity [pubic hair development class 3 compared with class 1: OR, 3.44 (95% CI: 1.44, 8.20)]. In females, the association with adult height became inverse after adjusting for prepubertal height [pubic hair development class 3 compared with class 1: females, −1.31 cm (95% CI: −2.32, −0.31)]; in males, the association with height was attenuated with this adjustment [−0.56 cm (95% CI: −1.63, 0.52)]. Associations with adiposity were attenuated after adjusting for prepubertal adiposity. Conclusions: Progression through puberty modifies the relation between prepubertal and adult anthropometry. Screening for early or rapid progression of puberty might identify children at an increased risk of becoming overweight or obese adults. PMID:27335138

  10. PROCEEDINGS: JOINT SYMPOSIUM ON DRY SO2 AND SIMULTANEOUS SO2/NOX CONTROL TECHNOLOGIES (1ST). VOLUME 1. FUNDAMENTAL RESEARCH AND PROCESS DEVELOPMENT

    EPA Science Inventory

    Forty six papers describing recent advances in dry sorbent injection technologies for SO2 control were presented at the 1st Joint Symposium on Dry SO2 and Simultaneous SO2/NOx Control Technologies. These papers covered the following topics: fundamental research; pilot-scale devel...

  11. The Role of Supported Joint Engagement and Parent Utterances in Language and Social Communication Development in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Bottema-Beutel, Kristen; Yoder, Paul J.; Hochman, Julia M.; Watson, Linda R.

    2014-01-01

    This study examined associations between three parent-child engagement states and social communication, expressive language, and receptive language at 8 month follow-up, in 63 preschool-age children with autism spectrum disorder. We extend the literature on supported joint engagement by dividing this state into higher order (HSJE) and lower order…

  12. Joint-Working as a Policy for Reducing Inequalities in Access to Information: Developing Culturally Appropriate Sex and Relationships Education for Young Bangladeshis in London

    ERIC Educational Resources Information Center

    Fernandez, Teena; Chapman, Jenifer; Estcourt, Claudia S.

    2008-01-01

    Introduction: Despite government support of culturally appropriate sex and relationships education (SRE), young people's access to information is limited and sexual health needs are not being met, particularly among youth from black and minority ethnic groups. Joint-working between health, education, voluntary sectors and parents has been heralded…

  13. Study for Agricultural Engineering Development in Brazil. Summary Report of Joint Study Group on Agricultural Engineering in Brazil (July 24-August 12, 1972).

    ERIC Educational Resources Information Center

    National Academy of Sciences, Washington, DC.

    The joint study group was established to identify the most urgent research and training needs in agricultural engineering in Brazil and to recommend how best to meet those needs. Specific recommendations are given for a long-term program to establish quality programs in education and research in agricultural engineering in Brazil and means to gain…

  14. Military Personnel: Joint Officer Development Has Improved, But a Strategic Approach Is Needed. Report to the Subcommittee on Military Personnel, Committee on Armed Services, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    In response to the need of military leaders to be better prepared to plan, support, and conduct joint (multi-service and multi-national) operations, Congress enacted the Goldwater- Nichols Department of Defense Reorganization Act of 1986. Positive steps were taken to implement provisions in the Act that address the education, assignment, and…

  15. Hypermobile joints

    MedlinePlus

    ... too far. In children with hypermobility syndrome, those ligaments are loose or weak. This may lead to: Arthritis, which may develop over time Dislocated joints, which is a separation of two bones where they meet at a joint Sprains and strains Children with hypermobile joints also often have flat ...

  16. Nozzle development

    SciTech Connect

    Dodge, F.T.; Dodge, L.G.; Johnson, J.E.

    1989-06-01

    The objective of this program has been the development of experimental techniques and data processing procedures to allow for the characterization of multi-phase fuel nozzles using laboratory tests. Test results were to be used to produce a single value coefficient-of-performance that would predict the performance of the fuel nozzles independent of system application. Several different types of fuel nozzles capable of handling multi-phase fuels have been characterized for: (a) fuel flow rate versus delivery pressure, (b) fuel-air ratio throughout the fuel spray or plume and the effective cone angle of the injector, and (c) fuel drop- or particle-size distribution as a function of fluid properties. Fuel nozzles which have been characterized on both single-phase liquids and multi-phase liquid-solid slurries include a variable-film-thickness nozzle, a commercial coal-water slurry (CWS) nozzle, and four diesel injectors of different geometries (tested on single-phase fluids only). Multi-phase mixtures includes CWS with various coal loadings, surfactant concentrations, and stabilizer concentrations, as well as glass-bead water slurries with stabilizing additives. Single-phase fluids included glycerol-water mixtures to vary the viscosity over a range of 1 to 1500 cP, and alcohol-water mixtures to vary the surface tension from about 22 to 73 dyne/cm. In addition, tests were performed to characterize straight-tube gas-solid nozzles using two differences size distributions of glass beads in air. Standardized procedures have been developed for processing measurements of spray drop-size characteristics and the overall cross-section average drop or particle size. 43 refs., 60 figs., 7 tabs.

  17. How to Develop College Students' Autonomous English Learning Skills--Take Reading Course in Joint-Program in HCFT as an Example

    ERIC Educational Resources Information Center

    Wang, Jihui

    2010-01-01

    The studies on autonomous learning based on the theories of constructivism and the advantages of technology propose valuable ideas for modern teaching theories and practices. In this paper, we put forward ways and methods in developing learner awareness, learning strategies and habits of autonomous learning in Henan College of Finance and Taxation…

  18. You Get What You Get and You Don't Throw a Fit!: Emotion Socialization and Child Physiology Jointly Predict Early Prosocial Development

    ERIC Educational Resources Information Center

    Scrimgeour, Meghan B.; Davis, Elizabeth L.; Buss, Kristin A.

    2016-01-01

    Prosocial behavior in early childhood is a precursor to later adaptive social functioning. This investigation leveraged mother-reported, physiological, and observational data to examine children's prosocial development from age 2 to age 4 (N = 125). Maternal emotion socialization (ES) strategies and children's parasympathetic regulation have each…

  19. Workforce Development and West Virginia: The West Virginia University Approach. Presented to the West Virginia Legislature Joint Education Committee, September 14, 1998.

    ERIC Educational Resources Information Center

    Hardesty, David C., Jr.

    This report highlights the services and programs for workforce development that are available through West Virginia University's (WVU) statewide network of schools, colleges, regional campuses, extension offices, and research units, but does not include four-year undergraduate or graduate programs. Specific sections address the following services,…

  20. USSR: Measures of Economic Growth and Development, 1950-80. Studies Prepared for the Use of the Joint Economic Committee, 97th Congress, Second Session.

    ERIC Educational Resources Information Center

    Joint Economic Committee, Washington, DC.

    Because the Soviet Union does not publish measures of economic growth and development comparable with those of Western countries, the Central Intelligence Agency has provided (by means of a large research effort carried out over many years) estimates of the value of the Soviet gross national product (GNP), its rate of growth, its size relative to…

  1. Quality of Rural Economic Development Data. Testimony to the Subcommittee on Agriculture and Transportation, Joint Economic Committee, Ninety-Ninth Congress (June 13, 1985).

    ERIC Educational Resources Information Center

    Pulver, Glen C.

    Although the private sector has the primary role for job generation in the U.S. market economy, local community leaders can play a significant part in creating a growth-stimulating economic environment. A comprehensive economic development strategy appropriate to a community's specific goals and conditions requires careful analysis of the…

  2. Interprofessional Learning – Development and Implementation of Joint Medical Emergency Team Trainings for Medical and Nursing Students at Universitätsmedizin Greifswald

    PubMed Central

    Partecke, Maud; Balzer, Claudius; Finkenzeller, Ingmar; Reppenhagen, Christiane; Hess, Ulrike; Hahnenkamp, Klaus; Meissner, Konrad

    2016-01-01

    Introduction: Interprofessional collaboration is of great importance in clinical practice, particularly in the field of emergency medicine. The professions involved in providing emergency care must work hand in hand, and tasks and routines must be coordinated effectively. However, medical and nursing students have only few opportunities to experience interprofessional cooperation during their formal training. Addressing this situation, the Department of Anesthesiology and the Vocational School of Greifswald University Medical School initiated a project to increase patient safety by integrating interprofessional human factor training into the curriculum of both health professions. This manuscript addresses how an interprofessional course module focusing on clinical emergency medicine can be taught with an emphasis on competency and problem-solving. In addition, it was important to identify suitable instruments for systematic quality development and assurance of this teaching and learning format. Project description: The aim of the project, which took place from October 2013 to September 2015, was the development, implementation and evaluation of a simulation-based, interprofessional course module on clinical emergency medicine. Target groups were medical and nursing students. Modern pedagogical models and methods were applied to the design and teaching of the course content. The project was carried out in separate phases: definition, planning, practical implementation, evaluation and documentation. The project was accompanied by systematic quality development. Established guidelines for quality-centered school development were applied to quality development, assurance and evaluation. Results: Over two years, a 16 credit-hour course module was developed and then taught and evaluated during the 2014 and 2015 summer semesters. A total of 120 medical students and 120 nursing students participated in the course module. Eighteen teachers from medicine and nursing were

  3. Laser forming process development

    SciTech Connect

    Blake, R.J.

    1996-12-31

    This paper is a summary of the activities performed for the process development of laser thermal forming sheet metal parts in support of rapid prototyping. A 400 watt pulsed Nd:YAG laser and 50 watt desktop CO{sub 2} laser were used during initial process development. Several tool-assisted laser forming approaches were conceived during the development of the process, and simple fixtures for process development/understanding were used throughout all testing. Much of the actual forming was performed with the base material in an unfixtured state. CRES (304) was used for baseline development, but the effort was directed toward forming titanium (e.g., 6Al-4V, 15V-3Cr-3Sn-3Al). Several DOE (i.e., Design of Experiment) techniques were employed during development and a Neural Net Computer Model was conceived for process control. This program was a joint effort in cooperation with the American Welding Society under contract with the Defense Advanced Research Projects Agency (DARPA). A synopsis of the laser forming process development, future opportunities, and applications are presented.

  4. Signposts to Literacy for Sustainable Development

    ERIC Educational Resources Information Center

    UNESCO Institute for Lifelong Learning (NJ1), 2008

    2008-01-01

    The two studies included in this volume, both dealing with the subject of literacy and sustainable development, are joint winners of the 2004-2005 International Award for Literacy Research, sponsored jointly by the UNESCO Institute for Lifelong Learning, Hamburg, the Swedish International Development Cooperation Agency (SIDA) and the Canadian…

  5. Sampling Development

    PubMed Central

    Adolph, Karen E.; Robinson, Scott R.

    2011-01-01

    Research in developmental psychology requires sampling at different time points. Accurate depictions of developmental change provide a foundation for further empirical studies and theories about developmental mechanisms. However, overreliance on widely spaced sampling intervals in cross-sectional and longitudinal designs threatens the validity of the enterprise. This article discusses how to sample development in order to accurately discern the shape of developmental change. The ideal solution is daunting: to summarize behavior over 24-hour intervals and collect daily samples over the critical periods of change. We discuss the magnitude of errors due to undersampling, and the risks associated with oversampling. When daily sampling is not feasible, we offer suggestions for sampling methods that can provide preliminary reference points and provisional sketches of the general shape of a developmental trajectory. Denser sampling then can be applied strategically during periods of enhanced variability, inflections in the rate of developmental change, or in relation to key events or processes that may affect the course of change. Despite the challenges of dense repeated sampling, researchers must take seriously the problem of sampling on a developmental time scale if we are to know the true shape of developmental change. PMID:22140355

  6. MPAS-Ocean Development Update

    SciTech Connect

    Jacobsen, Douglas W.; Ringler, Todd D.; Petersen, Mark R.; Jones, Philip W.; Maltrud, Mathew E.

    2012-06-13

    The Model for Prediction Across Scales (MPAS) is a modeling framework developed jointly between NCAR and LANL, built to allow core developers to: rapidly develop new dynamical cores, and leverage improvements made to shared codes. MPAS-Ocean (MPAS-O) is a functioning ocean model capable of high resolution, or highly vairable resolution simulations. The first MPAS-O publication is expected by the end of the year.

  7. The Russian-U.S. Experience with Development Joint Medical Support Procedures for Before and After Long-Duration Space Flights

    NASA Technical Reports Server (NTRS)

    Morgun, V. V.; Voronin, L. I.; Kaspransky, R. R.; Pool, S. L.; Barratt, M. R.; Novinkov, O. L.

    1999-01-01

    As the Russian Space Agency (RSA) and the U.S. National Aviation and Space Administration (NASA) began in the mid 1990s to plan a preliminary cooperative flight program in anticipation of the International Space Station, programmatic and philosophical differences became apparent in the technical and medical approaches of the two agencies. This paper briefly describes some of these differences and the process by which the two sides resolved differences in their approaches to the medical selection and certification of Shuttle-Mir crew members. These negotiations formed the basis for developing policies on other aspects of the medical support function for international missions, including crew training, preflight and postflight data collection, and rehabilitation protocols. The experience gained through this cooperative effort has been invaluable for developing medical care capabilities for the International Space Station.

  8. Joint federal research and development process to meet state and local needs. Part 1. Science and technology and political decision making

    SciTech Connect

    Wise, H F; Smith, L K; Einsweiler, R C; Jensen, D E

    1980-10-01

    This part of the handbook addresses the basic how to do it - how states and local governments can identify complex and cross-cutting issues and develop and manage scientific and technical resources in seeking policy solutions to such issues. The following subjects are discussed: background statement of the issue; the research/decision-making process; defining problems and identifying research components; research and decision-making strategies; how to identify existing knowledge or ongoing research in the area of policy concern; and managing multi-disciplinary research. The fourteen agencies involved in this effort include: US Departments of Energy, Agriculture, Transportation, Housing and Urban Development, Environmental Protection Agency, and National Science Foundation. (PSB)

  9. Mobile Router Technology Development

    NASA Technical Reports Server (NTRS)

    Ivancic, William D.; Stewart, David H.; Bell, Terry L.; Kachmar, Brian A.; Shell, Dan; Leung, Kent

    2002-01-01

    Cisco Systems and NASA have been performing joint research on mobile routing technology under a NASA Space Act Agreement. Cisco developed mobile router technology and provided that technology to NASA for applications to aeronautic and space-based missions. NASA has performed stringent performance testing of the mobile router, including the interaction of routing and transport-level protocols. This paper describes mobile routing, the mobile router, and some key configuration parameters. In addition, the paper describes the mobile routing test network and test results documenting the performance of transport protocols in dynamic routing environments.

  10. RDBE Development and Progress

    NASA Technical Reports Server (NTRS)

    Niell, A.; Bark, M.; Beaudoin, C.; Brisken, W.; Frej, H. Ben; Doeleman, S.; Durand, S.; Guerra, M.; Hinton, A.; Luce, M.; McWhirter, R.; Morris, K.; Peck, G.; Revnell, M.; Rogers, A.; Romney, J.; Ruszczyk, C.; Taveniku, M.; Walker, R.; Whitney, A.

    2010-01-01

    A digital backend based on the ROACH board has been developed jointly by the National Radio Astronomy Observatory and MIT Haystack Observatory. The RDBE will have both Polyphase Filterbank and Digital Downconverter personalities. The initial configuration outputs sixteen 32-MHz channels, comprised of half the channels from the PFB processing of the two IF inputs, for use in the VLBI2010 geodetic system and in the VLBA sensitivity upgrade project. The output rate is 2x109 bits/second (1x10(exp 9) bits/sec = 1 Gbps) over a 10 GigE connection to the Mark 5C with the data written in Mark 5B format on disk.

  11. Development of Kevlar parachute webbings

    SciTech Connect

    Ericksen, R.H.

    1991-01-01

    This paper describes the development of Kevlar webbings for parachute applications. Evaluation of existing webbings and a study of the effects of filling yarn denier and pick count on tensile and joint strength provided data for fabric design. Measurements of warp crimp as a function of filling denier and pick count demonstrated the relationship between warp crimp and strength. One newly developed webbing had higher strength efficiency and another had higher joint efficiency than comparable existing webbings. Both new webbings had overall efficiencies over 5% higher than values for existing webbings. 10 refs., 4 figs., 2 tabs.

  12. Ultrasonic Additive Manufacturing: Weld Optimization for Aluminum 6061, Development of Scarf Joints for Aluminum Sheet Metal, and Joining of High Strength Metals

    NASA Astrophysics Data System (ADS)

    Wolcott, Paul J.

    Ultrasonic additive manufacturing (UAM) is a low temperature, solid-state manufacturing process that enables the creation of layered, solid metal structures with designed anisotropies and embedded materials. As a low temperature process, UAM enables the creation of active composites containing smart materials, components with embedded sensors, thermal management devices, and many others. The focus of this work is on the improvement and characterization of UAM aluminum structures, advancing the capabilities of ultrasonic joining into sheet geometries, and examination of dissimilar material joints using the technology. Optimized process parameters for Al 6061 were identified via a design of experiments study indicating a weld amplitude of 32.8 synum and a weld speed of 200 in/min as optimal. Weld force and temperature were not significant within the levels studied. A methodology of creating large scale builds is proposed, including a prescribed random stacking sequence and overlap of 0.0035 in. (0.0889 mm) for foils to minimize voids and maximize mechanical strength. Utilization of heat treatments is shown to significantly increase mechanical properties of UAM builds, within 90% of bulk material. The applied loads during the UAM process were investigated to determine the stress fields and plastic deformation induced during the process. Modeling of the contact mechanics via Hertzian contact equations shows that significant stress is applied via sonotrode contact in the process. Contact modeling using finite element analysis (FEA), including plasticity, indicates that 5000 N normal loads result in plastic deformation in bulk aluminum foil, while at 3000 N no plastic deformation occurs. FEA studies on the applied loads during the process, specifically a 3000 N normal force and 2000 N shear force, show that high stresses and plastic deformation occur at the edges of a welded foil, and base of the UAM build. Microstructural investigations of heat treated foils confirms

  13. Business Development Corporation, Inc.

    SciTech Connect

    Jasek, S.

    1995-12-31

    Business Development Corporation, Inc., is a company specializing in opportunity seeking and business development activities in the {open_quotes}new{close_quotes} post communist Central and Eastern Europe, with particular emphasis on the Republics of Poland and Slovakia. The company currently focuses its expertise on strategic investing and business development between Central Europe and the United States of America. In Poland and Slovakia, the company specializes in developing large scale energy and environmental {open_quotes}infrastructure{close_quotes} development projects on the federal, state, and local level. In addition, the company assists large state owned industries in the transformation and privatization process. Business Development Corporation has assisted and continues to assist in projects of national importance. The staff of experts advise numerous large Polish and Slovak companies, most owned or in the process of privatization, on matters of restructuring, finance, capital structure, strategic parternships or investors, mergers, acquisitions and joint ventures with U.S. based firms. The company also assists and advises on a variety of environmental and energy matters in the public and private sector.

  14. The Role of Supported Joint Engagement and Parent Utterances in Language and Social Communication Development in Children with Autism Spectrum Disorder

    PubMed Central

    Yoder, Paul J.; Hochman, Julia M.; Watson, Linda R.

    2014-01-01

    This study examined associations between three parent–child engagement states and social communication, expressive language, and receptive language at 8 month follow-up, in 63 preschool-age children with autism spectrum disorder. We extend the literature on supported joint engagement by dividing this state into higher order (HSJE) and lower order types, with HSJE involving greater reciprocity in toy play. We also examined parents’ follow-in utterances that co-occurred with each state. We found that only HSJE predicts later social communication and expressive language, while object engagement predicts receptive language. HSJE combined with follow-in utterances (HSJE+FI) predicts all three outcomes when controlling for HSJE+FI in other engagement states. When controlling for total HSJE, HSJE+FI is predictive of receptive language. PMID:24658867

  15. DEVELOPMENT, INSTALLATION AND OPERATION OF THE MPC&A OPERATIONS MONITORING (MOM) SYSTEM AT THE JOINT INSTITUTE FOR NUCLEAR RESEARCH (JINR) DUBNA, RUSSIA

    SciTech Connect

    Kartashov,V.V.; Pratt,W.; Romanov, Y.A.; Samoilov, V.N.; Shestakov, B.A.; Duncan, C.; Brownell, L.; Carbonaro, J.; White, R.M.; Coffing, J.A.

    2009-07-12

    The Material Protection, Control and Accounting (MPC&A) Operations Monitoring (MOM) systems handling at the International Intergovernmental Organization - Joint Institute for Nuclear Research (JINR) is described in this paper. Category I nuclear material (plutonium and uranium) is used in JINR research reactors, facilities and for scientific and research activities. A monitoring system (MOM) was installed at JINR in April 2003. The system design was based on a vulnerability analysis, which took into account the specifics of the Institute. The design and installation of the MOM system was a collaborative effort between JINR, Brookhaven National Laboratory (BNL) and the U.S. Department of Energy (DOE). Financial support was provided by DOE through BNL. The installed MOM system provides facility management with additional assurance that operations involving nuclear material (NM) are correctly followed by the facility personnel. The MOM system also provides additional confidence that the MPC&A systems continue to perform effectively.

  16. Hope for the Future: Organizational Development Through Human Development.

    ERIC Educational Resources Information Center

    Burns, Martha A.; Hartsock, Linda S.

    Organizational effectiveness must rely above all else on the development and interaction of human beings within the organization's context. This basic premise set the stage for a joint research project on institutions of higher education which was completed in 1971. The researchers examined institutions from the perspective of members of…

  17. An integrated health care system's approach to development of a process to collect patient functional outcomes on total joint replacement procedures.

    PubMed

    Topel, Amy M; Schini, Cynthia A

    2014-01-01

    Health care organizations are challenged to find ways to measure not only process of care but also outcomes of care. Gundersen Health System's Orthopaedic Surgery Department in the La Crosse, Wisconsin area developed a process to collect outcomes of care for patients having hip or knee arthroplasty procedures and planned to use these data to determine impact on patients' lives. The Hip Osteoarthritis Outcomes Score and Knee Osteoarthritis Outcomes Score, adapted from the widely used Western Ontario and McMaster Universities Osteoarthritis Index, were collected preoperatively and at 1 year postoperatively. From these data, the health system determined that patients were experiencing significant improvement in 4 of 5 scales. Further recommendations include evaluating the impact of patients' age, sex, and preoperative body mass index on outcomes, as well as evaluating the impact of more patient involvement in goal setting on recovery time and functional outcomes. PMID:23687238

  18. Faculty Development. [SITE 2002 Section].

    ERIC Educational Resources Information Center

    Gillan, Bob, Ed.; McFerrin, Karen, Ed.

    This document contains the papers on faculty development from the SITE (Society for Information Technology & Teacher Education) 2002 conference. Topics covered include: integration for ESL (English as a Second Language) success; changing roles of college faculty; inducing reflection on educational practice; a joint instructional technology and…

  19. Engaging teachers, interpreters and emergency management educators in disaster preparedness and EarthScope science through joint professional development workshops (Invited)

    NASA Astrophysics Data System (ADS)

    Pratt-Sitaula, B. A.; Lillie, R. J.; Butler, R. F.; Hunter, N.; Magura, B.; Groom, R.; Hedeen, C. D.; Johnson, J. A.; Ault, C.; Olds, S. E.

    2013-12-01

    The same geological forces that form the spectacular beaches and headlands of the Pacific Northwest also threaten lives and infrastructure with earthquakes and tsunamis. A new project called the Cascadia EarthScope, Earthquake, and Tsunami Education Program (CEETEP), is helping to mitigate the effects of these potential disasters through collaboration building and professional development for K-12 teachers, park and museum interpreters, and emergency management outreach educators in communities along the Oregon and Washington coast. Tens of thousands of Oregon and Washington residents live within severe earthquake-shaking and tsunami-inundation zones, and millions of tourists visit state and federal parks in these same areas each year. Teachers in the K-12 school systems convey some basics about geological hazards to their students, and park rangers and museum educators likewise engage visitors at their sites. Emergency management educators make regular presentations to local residents about disaster preparedness. CEETEP is strengthening these efforts by providing community-based workshops that bring together all of these professionals to review the basic science of earthquakes and tsunamis, learn about EarthScope and other research efforts that monitor the dynamic Earth in the region, and develop ways to collectively engage students and the general public on the mitigation of coastal geologic hazards. As part of a nationwide effort, the NSF EarthScope Program has been deploying hundreds of seismic, GPS, and other geophysical instruments to measure movement of the Earth's crust and detect earthquakes along the Cascadia Subduction Zone. These instruments provide detail for ongoing research showing that coastal regions are storing energy that will be released in the next great Cascadia earthquake, with the resulting tsunami arriving onshore in 30 minutes or less. CEETEP is helping to convey these cutting-edge findings to coastal educators and fulfill Earth

  20. You get what you get and you don't throw a fit!: Emotion socialization and child physiology jointly predict early prosocial development.

    PubMed

    Scrimgeour, Meghan B; Davis, Elizabeth L; Buss, Kristin A

    2016-01-01

    Prosocial behavior in early childhood is a precursor to later adaptive social functioning. This investigation leveraged mother-reported, physiological, and observational data to examine children's prosocial development from age 2 to age 4 (N = 125). Maternal emotion socialization (ES) strategies and children's parasympathetic regulation have each been implicated in prosocial behavior, but are rarely examined together or prospectively. Given the transactional nature of parent-child relationships, the effects of maternal ES strategies on children's prosocial behavior are likely moderated by children's individual differences in parasympathetic regulation. As expected, mothers' reported use of problem-focused ES strategies predicted prosocial behavior at age 4. Additionally, children who showed parasympathetic reactivity consistent with more effective emotion regulation during a lab-based disappointment task were rated as more prosocial at age 4. Several interactions with maternal ES strategies emerged. Children's parasympathetic regulation moderated the relations between observed physical comfort or cognitive reframing and prosocial behavior. Observed distraction (either behavioral or cognitive) moderated the link between mothers' reported use of problem-focused ES strategies and children's prosocial behavior. Findings suggest that children's emerging prosocial behavior is shaped by the interactive contributions of interpersonal maternal ES as well as intrapersonal intrinsic physiological regulation. (PsycINFO Database Record PMID:26569566

  1. The development of a four-way linking framework in Egypt: an example of the FAO, OIE and WHO joint activities to facilitate national risk assessment.

    PubMed

    Forcella, Simona; El-din El Tantawy, Nasr; Yilma, Jobre; AbdelNabi, Amira; Claes, Filip; Dauphin, Gwenaelle; Mumford, Elizabeth

    2015-01-01

    Cross-sectoral assessment of health risks arising or existing at the human-animal interface is crucial to identifying and implementing effective national disease control measures. This requires availability of information from 4 functional information 'streams' - epidemiological, laboratory, animal, and human health. The Food and Agriculture Organization of the United Nations (FAO)/ World Organisation for Animal Health (OIE)/ World Health Organization (WHO) Four-Way Linking (4WL) project promotes the establishing of a national-level joint framework for data sharing, risk assessment, and risk communication, in order to both improve communications within and among governmental public health and animal health influenza laboratories, epidemiology offices, national partners, with the aim of strengthening the national capacity to detect, report and assess risks arising from emerging influenza viruses. The project is currently being implemented in countries where H5N1 avian influenza is endemic and where human cases have been reported. The project is comprised of two main activities at country level: a 'review mission', which is the project launch in the country and has the objective to assess the existing situation; and a 'scenario based workshop', with the scope to bring together key national partners and build relationships among people working in the 4 information streams and to improve understanding of national strengths and gaps. During the workshop the delegates engaged in interactive sessions on basic risk assessment and devoted to specify the needs and roles of the 4 different streams. The participants work through a mock influenza outbreak scenario, which practically illustrates how risk assessment and communication of an emergency at the animal-human interface is more effective when there is linking of the 4 streams, collaboration, communication, and coordinated action. In 2010, Egypt was the first country where the project was successfully implemented

  2. Developing regionalized models of lithospheric thickness and velocity structure across Eurasia and the Middle East from jointly inverting P-wave and S-wave receiver functions with Rayleigh wave group and phase velocities

    SciTech Connect

    Julia, J; Nyblade, A; Hansen, S; Rodgers, A; Matzel, E

    2009-07-06

    In this project, we are developing models of lithospheric structure for a wide variety of tectonic regions throughout Eurasia and the Middle East by regionalizing 1D velocity models obtained by jointly inverting P-wave and S-wave receiver functions with Rayleigh wave group and phase velocities. We expect the regionalized velocity models will improve our ability to predict travel-times for local and regional phases, such as Pg, Pn, Sn and Lg, as well as travel-times for body-waves at upper mantle triplication distances in both seismic and aseismic regions of Eurasia and the Middle East. We anticipate the models will help inform and strengthen ongoing and future efforts within the NNSA labs to develop 3D velocity models for Eurasia and the Middle East, and will assist in obtaining model-based predictions where no empirical data are available and for improving locations from sparse networks using kriging. The codes needed to conduct the joint inversion of P-wave receiver functions (PRFs), S-wave receiver functions (SRFs), and dispersion velocities have already been assembled as part of ongoing research on lithospheric structure in Africa. The methodology has been tested with synthetic 'data' and case studies have been investigated with data collected at an open broadband stations in South Africa. PRFs constrain the size and S-P travel-time of seismic discontinuities in the crust and uppermost mantle, SRFs constrain the size and P-S travel-time of the lithosphere-asthenosphere boundary, and dispersion velocities constrain average S-wave velocity within frequency-dependent depth-ranges. Preliminary results show that the combination yields integrated 1D velocity models local to the recording station, where the discontinuities constrained by the receiver functions are superimposed to a background velocity model constrained by the dispersion velocities. In our first year of this project we will (i) generate 1D velocity models for open broadband seismic stations in the

  3. Development of ITER Divertor Vertical Target with Annular Flow Concept - II: Development of Brazing Technique for CFC/CuCrZr Joint and Heating Test of Large-Scale Mock-Up

    SciTech Connect

    Ezato, K.; Dairaku, M.; Taniguchi, M.; Sato, K.; Suzuki, S.; Akiba, M.; Ibbott, C.; Tivey, R.

    2004-12-15

    The first fabrication and heating test of a large-scale carbon-fiber-composite (CFC) monoblock divertor mock-up using an annular flow concept has been performed to demonstrate its manufacturability and thermomechanical performance. This mock-up is based on the design of the lower part of the vertical target of the International Thermonuclear Experimental Reactor (ITER) divertor adapted for the annular flow concept. The annular cooling tube consists of two concentric tubes: an outer tube made of CuCrZr and an inner stainless steel tube with a twisted external fin. Prior to the fabrication of the mock-up, brazed joint tests between the CFC monoblock and the CuCrZr tube have been carried out to find the suitable heat treatment mitigating loss of the high mechanical strength of the CuCrZr material. A basic mechanical examination of CuCrZr undergoing the brazing heat treatment and finite element method analyses are also performed to support the design of the mock-up. High heat flux tests on the large-scale divertor mock-up have been performed in an ion beam facility. The mock-up has successfully withstood more than 1000 thermal cycles of 20 MW/m{sup 2} for 15 s and 3000 cycles of >10 MW/m{sup 2} for 15 s, which simulates the heat load condition of the ITER divertor. No degradation of the thermal performance of the mock-up has been observed throughout the thermal cycle test although in the tile with exposure to the heat flux of 20 MW/m{sup 2}, the erosion depth has been measured as 5.8 and 8.8 mm at the 300th and 500th cycles.

  4. Sustainable Development: The Challenge for Community Development.

    ERIC Educational Resources Information Center

    Gamble, Dorothy N.; Weil, Marie O.

    1997-01-01

    Five areas of inquiry shape the sustainable development movement: environmental movement, women's movement, overpopulation concerns, critique of development models, and new indicators of social progress. Community development workers are challenged to prepare local development projects within a sustainable development framework. (SK)

  5. Improved high-temperature gimbal joint

    NASA Technical Reports Server (NTRS)

    Winemiller, J. R.; Yee, S. T.; Neal, B. H.

    1972-01-01

    Development and characteristics of bellows gimbal joint for reduction of thermal stress effects are discussed. Reactions of designed joint to changes in temperature are described. Illustrations of conventional gimbal joint and improved gimbal joint are provided.

  6. Space Structure Development

    NASA Technical Reports Server (NTRS)

    Smith, Thomas

    2015-01-01

    The duration of my Summer 2015 Internship Tour at NASA's Johnson Space Center was spent working in the Structural Engineering Division's Structures Branch. One of the two main roles of the Structures Branch, ES2, is to ensure the structural integrity of spacecraft vehicles and the structural subsystems needed to support those vehicles. The other main objective of this branch is to develop the lightweight structures that are necessary to take humans beyond Low-Earth Orbit. Within ES2, my four projects involved inflatable space structure air bladder material testing; thermal and impact material testing for spacecraft windows; structural analysis on a joint used in the Boeing CST-100 airbag system; and an additive manufacturing design project.

  7. VAP Development: Initiation, Development, Evaluation, and Release

    SciTech Connect

    Jensen, M; Collis, Fast, J; Flynn, C; Mather, J; McFarlane, S; Monroe, J; Sivaraman, C; Xie, S

    2011-02-23

    This white paper provides a plan to formalize the evaluation of newly developed VAPs and a framework for the development of value-added products through four different stages: Initiation, Development, Evaluation, and Release.

  8. Developed-developing country partnerships: Benefits to developed countries?

    PubMed Central

    2012-01-01

    Developing countries can generate effective solutions for today’s global health challenges. This paper reviews relevant literature to construct the case for international cooperation, and in particular, developed-developing country partnerships. Standard database and web-based searches were conducted for publications in English between 1990 and 2010. Studies containing full or partial data relating to international cooperation between developed and developing countries were retained for further analysis. Of 227 articles retained through initial screening, 65 were included in the final analysis. The results were two-fold: some articles pointed to intangible benefits accrued by developed country partners, but the majority of information pointed to developing country innovations that can potentially inform health systems in developed countries. This information spanned all six WHO health system components. Ten key health areas where developed countries have the most to learn from the developing world were identified and include, rural health service delivery; skills substitution; decentralisation of management; creative problem-solving; education in communicable disease control; innovation in mobile phone use; low technology simulation training; local product manufacture; health financing; and social entrepreneurship. While there are no guarantees that innovations from developing country experiences can effectively transfer to developed countries, combined developed-developing country learning processes can potentially generate effective solutions for global health systems. However, the global pool of knowledge in this area is virgin and further work needs to be undertaken to advance understanding of health innovation diffusion. Even more urgently, a standardized method for reporting partnership benefits is needed—this is perhaps the single most immediate need in planning for, and realizing, the full potential of international cooperation between developed and

  9. Developed-developing country partnerships: benefits to developed countries?

    PubMed

    Syed, Shamsuzzoha B; Dadwal, Viva; Rutter, Paul; Storr, Julie; Hightower, Joyce D; Gooden, Rachel; Carlet, Jean; Bagheri Nejad, Sepideh; Kelley, Edward T; Donaldson, Liam; Pittet, Didier

    2012-01-01

    Developing countries can generate effective solutions for today's global health challenges. This paper reviews relevant literature to construct the case for international cooperation, and in particular, developed-developing country partnerships. Standard database and web-based searches were conducted for publications in English between 1990 and 2010. Studies containing full or partial data relating to international cooperation between developed and developing countries were retained for further analysis. Of 227 articles retained through initial screening, 65 were included in the final analysis. The results were two-fold: some articles pointed to intangible benefits accrued by developed country partners, but the majority of information pointed to developing country innovations that can potentially inform health systems in developed countries. This information spanned all six WHO health system components. Ten key health areas where developed countries have the most to learn from the developing world were identified and include, rural health service delivery; skills substitution; decentralisation of management; creative problem-solving; education in communicable disease control; innovation in mobile phone use; low technology simulation training; local product manufacture; health financing; and social entrepreneurship. While there are no guarantees that innovations from developing country experiences can effectively transfer to developed countries, combined developed-developing country learning processes can potentially generate effective solutions for global health systems. However, the global pool of knowledge in this area is virgin and further work needs to be undertaken to advance understanding of health innovation diffusion. Even more urgently, a standardized method for reporting partnership benefits is needed--this is perhaps the single most immediate need in planning for, and realizing, the full potential of international cooperation between developed and

  10. Entrepreneurial Intentions in Developing and Developed Countries

    ERIC Educational Resources Information Center

    Iakovleva, Tatiana; Kolvereid, Lars; Stephan, Ute

    2011-01-01

    Purpose: This study proposes to use the Theory of Planned Behaviour to predict entrepreneurial intentions among students in five developing and nine developed countries. The purpose is to investigate whether entrepreneurial intention and its antecedents differ between developing and developed countries, and to test the theory in the two groups of…

  11. App Development Paradigms for Instructional Developers

    ERIC Educational Resources Information Center

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    To create instructional apps for desktop, laptop and mobile devices, developers must select a development tool. Tool selection is critical and complicated by the large number and variety of app development tools. One important criterion to consider is the type of development environment, which may primarily be visual or symbolic. Those distinct…

  12. 7 CFR 550.16 - Project development.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Project development. 550.16 Section 550.16 Agriculture... § 550.16 Project development. REE provides partial funding to Cooperators to support research projects... the REE Agency's ADODR shall jointly develop the following documentation: (a) Project plan. A...

  13. 7 CFR 550.16 - Project development.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Project development. 550.16 Section 550.16 Agriculture... § 550.16 Project development. REE provides partial funding to Cooperators to support research projects... the REE Agency's ADODR shall jointly develop the following documentation: (a) Project plan. A...

  14. 7 CFR 550.16 - Project development.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Project development. 550.16 Section 550.16 Agriculture... § 550.16 Project development. REE provides partial funding to Cooperators to support research projects... the REE Agency's ADODR shall jointly develop the following documentation: (a) Project plan. A...

  15. Modeling forest development after fire disturbance: Climate, soil organic layer, and nitrogen jointly affect forest canopy species and long-term ecosystem carbon accumulation in the North American boreal forest

    NASA Astrophysics Data System (ADS)

    Trugman, A. T.; Fenton, N.; Bergeron, Y.; Xu, X.; Welp, L.; Medvigy, D.

    2015-12-01

    less able to compete with needleleaf trees under low nitrogen regimes. We conclude that a joint regulation between the soil organic layer, temperature, and nitrogen will likely play an important role in influencing boreal forests development after fire in future climates, and should be represented in models.

  16. Advanced Launch Development Program status

    NASA Technical Reports Server (NTRS)

    Colgrove, Roger

    1990-01-01

    The Advanced Launch System is a joint NASA - Air Force program originally directed to define the concept for a modular family of launch vehicles, to continue development programs and preliminary design activities focused primarily on low cost to orbit, and to offer maturing technologies to existing systems. The program was restructed in the spring of 1990 as a result of funding reductions and renamed the Advanced Launch Development Program. This paper addresses the program's status following that restructuring and as NASA and the Air Force commence a period of deliberation over future space launch needs and the budgetary resources available to meet those needs. The program is currently poised to protect a full-scale development decision in the mid-1990's through the appropriate application of program resources. These resources are concentrated upon maintaining the phase II system contractor teams, continuing the Space Transportation Engine development activity, and refocusing the Advanced Development Program demonstrated activities.

  17. Advanced Emissions Control Development Program

    SciTech Connect

    A.P.Evans; K.E. Redinger; M.J. Holmes

    1998-04-01

    The objective of the Advanced Emissions Control Development Program (AECDP) is to develop practical, cost-effective strategies for reducing the emissions of air toxics from coal-fired boilers. Ideally, the project aim is to effectively control air toxic emissions through the use of conventional flue gas cleanup equipment such as electrostatic precipitators (ESPS), fabric filters (baghouse), and wet flue gas desulfurization. Development work to date has concentrated on the capture of mercury, other trace metals, fine particulate and hydrogen chloride. Following the construction and evaluation of a representative air toxics test facility in Phase I, Phase II focused on the evaluation of mercury and several other air toxics emissions. The AECDP is jointly funded by the United States Department of Energy's Federal Energy Technology Center (DOE), the Ohio Coal Development Office within the Ohio Department of Development (oCDO), and Babcock& Wilcox-a McDermott company (B&W).

  18. ASRM case insulation design and development

    NASA Astrophysics Data System (ADS)

    Bell, Matthew S.; Tam, William F. S.

    1992-10-01

    This paper describes the achievements made on the Advanced Solid Rocket Motor (ASRM) case insulation design and development program. The ASRM case insulation system described herein protects the metal case and joints from direct radiation and hot gas impingement. Critical failure of solid rocket systems is often traceable to failure of the insulation design. The wide ranging accomplishments included the development of a nonasbestos insulation material for ASRM that replaced the existing Redesigned Solid Rocket Motor (RSRM) asbestos-filled nitrile butadiene rubber (NBR) along with a performance gain of 300 pounds, and improved reliability of all the insulation joint designs, i.e., segmented case joint, case-to-nozzle and case-to-igniter joint. The insulation process development program included the internal stripwinding process. This process advancement allowed Aerojet to match to exceed the capability of other propulsion companies.

  19. ASRM case insulation design and development

    NASA Technical Reports Server (NTRS)

    Bell, Matthew S.; Tam, William F. S.

    1992-01-01

    This paper describes the achievements made on the Advanced Solid Rocket Motor (ASRM) case insulation design and development program. The ASRM case insulation system described herein protects the metal case and joints from direct radiation and hot gas impingement. Critical failure of solid rocket systems is often traceable to failure of the insulation design. The wide ranging accomplishments included the development of a nonasbestos insulation material for ASRM that replaced the existing Redesigned Solid Rocket Motor (RSRM) asbestos-filled nitrile butadiene rubber (NBR) along with a performance gain of 300 pounds, and improved reliability of all the insulation joint designs, i.e., segmented case joint, case-to-nozzle and case-to-igniter joint. The insulation process development program included the internal stripwinding process. This process advancement allowed Aerojet to match to exceed the capability of other propulsion companies.

  20. Recent developments in PVRC gasket testing

    SciTech Connect

    Hsu, K.H.; Payne, J.R.; Derenne, M.

    1996-12-01

    For the past 15--20 years, a major research program aimed at solving the problem of leakage of gasketed flanged joints has been undertaken by the Pressure Vessel Research Council (PVRC). This program has resulted in greatly enhanced understanding of the leakage phenomena of a flanged joint and improvements of the ASME Code design procedures. The PVRC bolted flanged program has been organized into six areas: (1) implement PVRC gasket constants and test procedure development; (2) issue a flange design guidelines report considering items such as modeling, tightness, transients, relaxation, etc.; (3) flange rating parameters for standard flanges; (4) design parameters for ASME joints; (5) gasket testing for temperature behavior data and test method developments; and (6) flanged joint assembly and interaction effects. This paper presents an update of the recent developments in the area of gasket testing; specifically, testing on flexible graphite gaskets, elastomeric sheet gaskets, and fugitive emissions gasket characteristics with various types of fluids are described.

  1. What Is Development?

    ERIC Educational Resources Information Center

    Astle, Alec

    1989-01-01

    Reviews inequalities in development, a topic in the New Zealand Form Six Geography Syllabus. Explains the different perspectives from which to approach development: academic, ideological, political, or personal. Considers the various meanings of development to less developed countries. (GG)

  2. Drug Development Process

    MedlinePlus

    ... Approvals The Drug Development Process The Drug Development Process Share Tweet Linkedin Pin it More sharing options ... public. More Information More in The Drug Development Process Step 1: Discovery and Development Step 2: Preclinical ...

  3. PUBLISHER'S ANNOUNCEMENT: Editorial developments Editorial developments

    NASA Astrophysics Data System (ADS)

    Gillan, Rebecca

    2009-01-01

    We are delighted to announce that from January 2009, Professor Murray T Batchelor of the Australian National University, Canberra will be the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Murray Batchelor has been Editor of the Mathematical Physics section of the journal since 2007. Prior to this, he served as a Board Member and an Advisory Panel member for the journal. His primary area of research is the statistical mechanics of exactly solved models. He holds a joint appointment in mathematics and physics and has held visiting positions at the Universities of Leiden, Amsterdam, Oxford and Tokyo. We very much look forward to working with Murray to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Carl M Bender. Carl has done a magnificent job as Editor-in-Chief and has worked tirelessly to improve the journal over the last five years. Carl has been instrumental in designing and implementing strategies that have enhanced the quality of papers published and service provided by Journal of Physics A: Mathematical and Theoretical. Notably, under his tenure, we have introduced the Fast Track Communications (FTC) section to the journal. This section provides a venue for outstanding short papers that report new and timely developments in mathematical and theoretical physics and offers accelerated publication and high visibility for our authors. During the last five years, we have raised the quality threshold for acceptance in the journal and now reject over 60% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average less than 50 days for papers. We have recently announced another innovation; the Journal of Physics A Best Paper Prize. These prizes will honour excellent papers

  4. Developing New Academic Developers: Doing before Being?

    ERIC Educational Resources Information Center

    Kensington-Miller, Barbara; Brailsford, Ian; Gossman, Peter

    2012-01-01

    A small group of new academic developers reflected on their induction into the profession and wondered if things could have been done differently. The researchers decided to question the directors of three tertiary academic development units about how they recruited new developers, what skills and competences they looked for and how they inducted…

  5. Interleaved arrays antenna technology development

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Phase one and two of a program to further develop and investigate advanced graphite epoxy waveguides, radiators, and components with application to space antennas are discussed. The objective of the two phases were to demonstrate mechanical integrity of a small panel of radiators and parts procured under a previous contract and to develop alternate designs and applications of the technology. Most of the emphasis was on the assembly and test of a 5 x 5 element module. This effort was supported by evaluation of adhesives and waveguide joint configurations. The evaluation and final assembly considered not only mechanical performance but also producibility in large scale.

  6. Proposed IDEA Regulations. Joint Hearing of the Committee on Labor and Human Resources, United States Senate, and the Committee on Education and the Workforce, House of Representatives, on Examining the Department of Education's Development of the Regulations Necessary To Implement the Individuals with Disabilities Education Act Amendments of 1997 (Public Law 105-17). One Hundred Fifth Congress, Second Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    This is a transcript from a Joint Hearing of the U.S. Senate Committee on Labor and Human Resources and the U.S. House of Representatives Committee on Education and the Workforce that addresses the U.S. Department of Education's development of regulations necessary to implement the Individuals with Disabilities Education Act (IDEA) Amendments of…

  7. Comprehensive Child Development Act of 1971. Part 3. (Joint Hearings Before the Subcommittee on Employment, Manpower, and Poverty and the Subcommittee on Children and Youth of the Committee on Labor and Public Welfare, United States Senate, Ninety-Second Congress, First Session on S.1512)

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

    This document presents Part Three (pages 673-930) of the joint hearings held May 27 and June 16, 1971 before two subcommittees of the Committee on Labor and Public Welfare. The hearings were designed to amend the Economic Opportunity Act of 1964 to provide for a comprehensive child development program in the department of Health, Education and…

  8. The TATL Framework for CALL Development

    ERIC Educational Resources Information Center

    Ni Chiaráin, Neasa; Ni Chasaide, Ailbhe

    2015-01-01

    The Theory Actions Technology Learner context (TATL) framework provides an initial analysis tool to guide Computer-Assisted Language Learning (CALL) development. It entails joint consideration of four key factors that need to be considered prior and during development activities: (1) the underlying pedagogical theory; (2) the learning tasks…

  9. Training for Agriculture and Rural Development--1975.

    ERIC Educational Resources Information Center

    United Nations Food and Agriculture Organization, Rome (Italy).

    Eighteen papers about education, training, and extension in rural areas of the developing world are presented in this 1975 journal published jointly by three United Nations agencies closely concerned with education and rural development: Food and Agriculture Organization; Education, Scientific, and Cultural Organization; International Labor…

  10. Developing Gifted Children in Hungarian Preschool Education

    ERIC Educational Resources Information Center

    Nagy, Iren; Papp, Irene

    2013-01-01

    At a conference, a secondary school teacher was very surprised when she heard about the idea of talent development in preschool education. "What does it mean?" she asked. In this paper we answer the above question with a model created by joint research. We describe our method of developing gifted children with the involvement of preschool teachers…

  11. Cooperation and Development

    ERIC Educational Resources Information Center

    M'Bow, Amadou-Mahtar

    1976-01-01

    International economic relations are discussed in terms of cultural, educational, and communications development globally. It is emphasized that global cooperation and development are necessary for development of people and societies. (ND)

  12. SIRU development. Volume 1: System development

    NASA Technical Reports Server (NTRS)

    Gilmore, J. P.; Cooper, R. J.

    1973-01-01

    A complete description of the development and initial evaluation of the Strapdown Inertial Reference Unit (SIRU) system is reported. System development documents the system mechanization with the analytic formulation for fault detection and isolation processing structure; the hardware redundancy design and the individual modularity features; the computational structure and facilities; and the initial subsystem evaluation results.

  13. Developing Teachers: Improving Professional Development for Teachers

    ERIC Educational Resources Information Center

    Coe, Robert; Aloisi, Cesare; Higgins, Steve; Major, Lee Elliot

    2015-01-01

    This document is a summary of the report "What Makes Great Teaching". It argues that improved teacher ­development will positively impact on pupil attainment, particular those from disadvantaged backgrounds. "Developing Teachers" presents five policy recommendations which have been signed by 17 of Britain's leading headteachers…

  14. Curriculum Development: Teacher Involvement in Curriculum Development

    ERIC Educational Resources Information Center

    Alsubaie, Merfat Ayesh

    2016-01-01

    In order for curriculum development to be effective and schools to be successful, teachers must be involved in the development process. An effective curriculum should reflect the philosophy, goals, objectives, learning experiences, instructional resources, and assessments that comprise a specific educational program ("Guide to curriculum…

  15. Child Development Associate. Body Skills Development.

    ERIC Educational Resources Information Center

    Office of Child Development (DHEW), Washington, DC.

    This Child Development Associate (CDA) training module, one of a series of 18, is intended to provide the intern with the knowledge and skills necessary for helping children develop their body skills. The module stipulates competency-based objectives and provides essential information, suggestions, examples and learning activities on three topics…

  16. Developing New Models for Collection Development.

    ERIC Educational Resources Information Center

    Stoffle, Carla J.; Fore, Janet; Allen, Barbara

    1999-01-01

    Discusses the need to develop new models for collection development in academic libraries, based on experiences at the University of Arizona. Highlights include changes in the organizational chart; focusing on users' information goals and needs; integrative services; shared resources; interlibrary loans; digital technology; and funding. (LRW)

  17. Ceramic brush seals development

    NASA Technical Reports Server (NTRS)

    Howe, Harold

    1994-01-01

    The following topics are discussed in this viewgraph presentation: ceramic brush seals, research and development, manufacturing, brazed assembly development, controlling braze flow, fiber selection, and braze results.

  18. Advanced cryogenic tank development status

    NASA Astrophysics Data System (ADS)

    Braun, G. F.; Tack, W. T.; Scholz, E. F.

    1993-06-01

    Significant advances have been made in the development of materials, structures, and manufacturing technologies for the next generation of cryogenic propellant tanks under the auspices of a joint U.S. Air Force/NASA sponsored advanced development program. This paper summarizes the achievements of this three-year program, particularly in the evolution and properties of Weldalite 049, net shape component technology, Al-Li welding technology, and efficient manufacturing concepts. Results of a recent mechanical property characterization of a full-scale integrally stiffened barrel panel extrusion are presented, as well as plans for an additional weld process optimization program using response surface design of experiment techniques. A further discussion is given to the status of hardware completed for the Advanced Manufacturing Development Center and Martin Marietta's commitment to the integration of these technologies into the production of low-cost, light-weight cryogenic propellant tanks.

  19. Education and Development: A Developing Theme

    NASA Astrophysics Data System (ADS)

    Brock-Utne, Birgit

    2002-03-01

    The following article is based on an analysis of selected examples from the approximately 2500 main articles that have been published in the International Review of Education ( IRE) since its inception in 1931 until the fall of 2001. The scope of the topic is education within developing countries and the promotion of such education by industrialised countries and development agencies. After an introduction on the growth of the concern over education and development over seven decades of the journal, three themes are looked at in some more detail: (1) The discussion on nationalism versus internationalism in education, a theme that bears clear relevance to the field "Education and Development" and has been with the journal from its inception but on which one finds more emphasis in the earlier volumes. (2) The language of instruction in developing countries. This theme has also been with the journal from its inception and it is still much debated. (3) The effects of external aid on the education sector in developing countries. Though massive economic aid in the form of grants or loans to the education sector in developing countries is of more recent nature external influence on the education sector has been there since colonial times.

  20. Options for developing countries in mining development

    SciTech Connect

    Walrond, G.W.; Kumar, R.

    1985-01-01

    This book is a study of the issues that developing countries face in planning and implementing mineral development, taking as case studies Botswana, Sierra Leone, Zambia, Tanzania, Malaysia, Papua New Guinea and the developed states of Quebec and Western Australia. The authors consider the major aspects of the matter including organization and administration; regulation; taxation and surplus distribution; the dynamics of such instruments as royalty, rent resource tax and capital allowances under various cost/price scenarios; and selected mining agreements and their key provisions. They stress throughout the need for foreign investment while maximizing the economic benefits reaped from exhaustible resources.

  1. Geothermal development opportunities in developing countries

    SciTech Connect

    Kenkeremath, D.C.

    1989-11-16

    This report is the proceedings of the Seminar on geothermal development opportunities in developing countries, sponsored by the Geothermal Division of the US Department of Energy and presented by the National Geothermal Association. The overall objectives of the seminar are: (1) Provide sufficient information to the attendees to encourage their interest in undertaking more geothermal projects within selected developing countries, and (2) Demonstrate the technological leadership of US technology and the depth of US industry experience and capabilities to best perform on these projects.

  2. Antenna development at DARPA

    NASA Astrophysics Data System (ADS)

    Corey, Larry; Jaska, Esko

    2004-09-01

    This paper reviews recent and ongoing antenna technology and systems development in the Special Projects Office of the Defense Advanced Research Projects Agency (DARPA/SPO). These programs fall into two categories: development and application of antenna component technologies and development of transportable phased-array radar antennas. These development programs are presented in a chronological order.

  3. Energy Sources and Development.

    ERIC Educational Resources Information Center

    Crank, Ron

    This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with energy sources and development. Its objective is for the student to be able to discuss energy sources and development related to the historical perspective, biological development, current aspects, and future expectations…

  4. Leadership Development. Symposium 12.

    ERIC Educational Resources Information Center

    2000

    Three presentations are provided from the Academy of Human Resource Development (HRD) 2000 Conference Proceedings. "Leadership Development: A Review of the Theory and Literature" (Susan A. Lynham) has four parts that analyze the leadership development process: the present state of the available body of knowledge on leadership development; core…

  5. LGBT Career Development

    ERIC Educational Resources Information Center

    Gedro, Julie

    2007-01-01

    In this paper, I would like to open a conversation with my HRD colleagues about the issues related to Lesbian, Gay, Bisexual and Transgender (LGBT) career development. This paper provides some insights about LGBT career development, analyzing the factors that distinguish LGBT career development from heterosexual career development.

  6. Directions in Staff Development

    ERIC Educational Resources Information Center

    Brew, Angela, Ed.

    This collection of readings is intended to provide a source book on best practices in staff development in higher education within a British context. The 13 papers are grouped into three parts: part 1 presents the educational development tradition which has focused on development of staff as teachers; part 2 considers development of staff in…

  7. Agile Software Development

    ERIC Educational Resources Information Center

    Biju, Soly Mathew

    2008-01-01

    Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on…

  8. Rural Development Issues.

    ERIC Educational Resources Information Center

    Economic Research Service (USDA), Washington, DC. Economic Development Div.

    Elements essential to an adequate framework for rural development in the U.S. are a national growth and development policy which includes a rural development strategy and definition of common problems and programmatic actions required to deal with them. Many past federal rural development programs (lacking a federal rural policy focus) have failed…

  9. Development of standards for superconductors

    NASA Astrophysics Data System (ADS)

    Goodrich, L. F.; Minervini, J. V.; Clakr, A. F.; Fickett, F. R.; Ekin, J. W.

    1985-01-01

    A cooperative program with the Department of Energy, the National Bureau of Standards, and private industry is in progress to develop standard measurement practices for use in large scale applications of superconductivity. The goal is the adoption of voluntary standards for the critical parameters and other characterizations of practical superconductors. Progress for the period January 82 through December 1983 is reported. The major effort was the procurement, selection, and certification of the first superconducting wire for critical current measurements as a Standard Reference Material (SRM 1457). Other work reported here includes: effect of geometry on current transfer; lap-joint resistance; and ac losses.

  10. European missile aerodynamics and developments

    NASA Astrophysics Data System (ADS)

    Gregoriou, G.

    1980-04-01

    The joint development of new generation missiles by many European countries not only minimizes the costs and the technological risks for each individual country, but also increases the degree of weapons systems standardization within NATO. Focal points of research in recent years include: (1) jet influence on the dispersion of artillery rockets; (2) problems associated with the vertical launch of missiles; and (3) air intakes of ramjets. These areas are examined with respect to their significance in missile design. Some characteristic theoretical and measurement results are given.

  11. Automotive Stirling Engine Development Program

    NASA Technical Reports Server (NTRS)

    Nightingale, N.; Richey, A.; Farrell, R.; Riecke, G.; Ernst, W.; Howarth, R.; Cronin, M.; Simetkosky, M.; Smith, G.; Meacher, J.

    1985-01-01

    Development test activities on Mod I engines directed toward evaluating technologies for potential inclusion in the Mod II engine are summarized. Activities covered include: test of a 12-tube combustion gas recirculation combustor; manufacture and flow-distribution test of a two-manifold annular heater head; piston rod/piston base joint; single-solid piston rings; and a digital air/fuel concept. Also summarized are results of a formal assessment of candidate technologies for the Mod II engine, and preliminary design work for the Mod II. The overall program philosophy weight is outlined, and data and test results are presented.

  12. Developing behavioral objectives for perioperative staff development.

    PubMed

    Beitz, J M

    1996-07-01

    Behavioral objectives (i.e., clear statements that describe intended instructional outcomes) are a crucial component of educational planning for perioperative staff development. Properly written objectives promote positive learning outcomes such as increased motivation, better retention of information, and improved instructional accountability. This article describes the advantages of using behavioral objectives, gives a historical perspective of their development, presents a practical "how-to" approach to formulating them, and delineates their link to the selection of appropriate evaluation methods. PMID:8827333

  13. Chemical probe development versus drug development.

    PubMed

    Jackson, Michael R

    2013-01-01

    Phosphatases as a class of proteins have recently attracted significant attention from the pharmaceutical industry. As our knowledge of this diverse family of proteins has grown, the relationship between phosphatases and human disease has clearly been established, with model systems proving much validation for the potential of some members of this family to be candidate drug targets. This, coupled with the fact that there have been a flood of successful drug development efforts over the past 10 years targeting protein kinases, has led some to propose that phosphatases as a class of enzymes might be equally as rich a source of drug targets as kinases. However to date there remain relatively few molecules targeting protein phosphatases in clinical development. This is less a reflection of their importance in key processes associated with disease, but rather seems to reflect inherent issues with developing drugs for many members of this family. This seems especially so for intracellular phosphatases where the development of selective, potent cell penetrant molecules with good drug-like properties has proven a formidable challenge. This chapter provides a brief outline of the two major processes that have resulted in the existing armament of chemical modulators of protein phosphatases, namely, chemical probe development and drug development. These two processes initially seem to be rather similar and while they do overlap, the stated goals of the two approaches at project initiation are distinct. PMID:23860644

  14. JOINT WORLD BANK INSTITUTE/EPA CHINA WORKSHOP ON ENFORCEMENT AND COMPLIANCE - E&C ROLES IN DEALING WITH CURRENT AND PROJECTED MAJOR ENVIRONMENTAL ISSUES IN CHINA'S ECONOMIC DEVELOPMENT

    EPA Science Inventory

    The World Bank Institute (WBI) provides funding for economic development in China. Modules of this funding are specifically dedicated for environmental protection projects. One of these modules is the development of compliance and enforcement. This is broken down into identifi...

  15. Cooperative research and development agreements at METC

    SciTech Connect

    Ludlow, J.C.; Jarr, L.A.; Anderson, R.J.

    1995-06-01

    The Federal Technology Transfer Act of 1986 (P.L. 99-502) provided a new mechanism for joint research between private parties and the Morgantown Energy Technology Center (METC). Joint projects under this law are called Cooperative Research And Development Agreements (CRADAs) and are simply agreements between METC and the private sector to work together on a mutually beneficial project. Of primary interest to METC is the development and deployment of: (1) clean, efficient power generation technologies, (2) technologies for the characterization and exploitation of the Nation`s natural gas resource, and (3) environmental remediation technologies.

  16. Development of a geodatabase and conceptual model of the hydrogeologic units beneath air force plant 4 and Naval Air Station-Joint Reserve Base Carswell Field, Fort Worth, Texas

    USGS Publications Warehouse

    Shah, Sachin D.

    2004-01-01

    Air Force Plant 4 and adjacent Naval Air Station-Joint Reserve Base Carswell Field at Fort Worth, Texas, constitute a government-owned, contractor-operated facility that has been in operation since 1942. Contaminants from AFP4, primarily volatile organic compounds and metals, have entered the ground-water-flow system through leakage from waste-disposal sites and from manufacturing processes. The U.S. Geological Survey developed a comprehensive geodatabase of temporal and spatial environmental information associated with the hydrogeologic units (alluvial aquifer, Goodland-Walnut confining unit, and Paluxy aquifer) beneath the facility and a three-dimensional conceptual model of the hydrogeologic units integrally linked to the geodatabase. The geodatabase design uses a thematic layer approach to create layers of feature data using a geographic information system. The various features are separated into relational tables in the geodatabase on the basis of how they interact and correspond to one another. Using the geodatabase, geographic data at the site are manipulated to produce maps, allow interactive queries, and perform spatial analyses. The conceptual model for the study area comprises computer-generated, three-dimensional block diagrams of the hydrogeologic units. The conceptual model provides a platform for visualization of hydrogeologic-unit sections and surfaces and for subsurface environmental analyses. The conceptual model is based on three structural surfaces and two thickness configurations of the study area. The three structural surfaces depict the altitudes of the tops of the three hydrogeologic units. The two thickness configurations are those of the alluvial aquifer and the Goodland-Walnut confining unit. The surface of the alluvial aquifer was created using a U.S. Geological Survey 10-meter digital elevation model. The 2,130 point altitudes of the top of the Goodland-Walnut unit were compiled from lithologic logs from existing wells, available soil

  17. Hanford Site Development Plan

    SciTech Connect

    Rinne, C.A.; Curry, R.H.; Hagan, J.W.; Seiler, S.W.; Sommer, D.J. ); Yancey, E.F. )

    1990-01-01

    The Hanford Site Development Plan (Site Development Plan) is intended to guide the short- and long-range development and use of the Hanford Site. All acquisition, development, and permanent facility use at the Hanford Site will conform to the approved plan. The Site Development Plan also serves as the base document for all subsequent studies that involve use of facilities at the Site. This revision is an update of a previous plan. The executive summary presents the highlights of the five major topics covered in the Site Development Plan: general site information, existing conditions, planning analysis, Master Plan, and Five-Year Plan. 56 refs., 67 figs., 31 tabs.

  18. Hanford Site Development Plan

    SciTech Connect

    Hathaway, H.B.; Daly, K.S.; Rinne, C.A.; Seiler, S.W.

    1993-05-01

    The Hanford Site Development Plan (HSDP) provides an overview of land use, infrastructure, and facility requirements to support US Department of Energy (DOE) programs at the Hanford Site. The HSDP`s primary purpose is to inform senior managers and interested parties of development activities and issues that require a commitment of resources to support the Hanford Site. The HSDP provides an existing and future land use plan for the Hanford Site. The HSDP is updated annually in accordance with DOE Order 4320.1B, Site Development Planning, to reflect the mission and overall site development process. Further details about Hanford Site development are defined in individual area development plans.

  19. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2004-07-28

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  20. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2005-01-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  1. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2005-04-30

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  2. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2004-10-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  3. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2003-10-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  4. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2004-04-30

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  5. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2002-07-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  6. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2002-11-01

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  7. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    SciTech Connect

    Kathryn Baskin

    2001-10-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  8. DELSY project: status and development.

    PubMed

    Balalykin, N; Beloshitsky, P; Bykovsky, V; Kobets, V; Kolobanov, V; Kulipanov, G; Levichev, E; Mikhaylin, V; Meshkov, I; Mezentsev, N; Morozov, N; Seleznev, I; Sidorov, G; Skrinsky, A; Shirkov, G; Syresin, E; Titkova, I; Yurkov, M

    2003-09-01

    The DELSY (Dubna Electron Synchrotron) project is under development at the Joint Institute for Nuclear Research [Arkhipov et al. (2001). Nucl. Instrum. Methods, A467, 57-62; Arkhipov et al. (2001). Nucl. Instrum. Methods, A470, 1-6; Titkova et al. (2000). Proceedings of the Seventh European Particle Accelerator Conference, pp. 702-704]. It is based on an acceleration facility donated to the Joint Institute for Nuclear Research by the Institute for Nuclear and High Energy Physics (NIKHEF, Amsterdam). The NIKHEF accelerator facility consists of the linear electron accelerator MEA, which has an electron energy of 700 MeV, and the electron storage ring AmPS, with a maximum energy of 900 MeV and a beam current of 200 mA. There are three phases to the construction of the DELSY facility. Phase I will be accomplished with the construction of a complex of free-electron lasers covering continuously the spectrum from the far infrared down to the ultraviolet ( approximately 150 nm). Phase II will be accomplished with the commissioning of the storage ring DELSY. Complete commissioning of the DELSY project will take place after finishing Phase III, the construction of an X-ray free-electron laser. This phase is considered as the ultimate goal of the project; it is currently under development and is not described in this paper. PMID:12944618

  9. The Developing Brain.

    ERIC Educational Resources Information Center

    Schatz, Carla J.

    1992-01-01

    Discusses neural activity and stimulation crucial in fetal brain development and the formation of the mind. Focuses on activity-dependent remodeling related to development of the visual system and retinal activity. (MCO)

  10. Developing the plan

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The basic sequence in the planning development process is discussed. Alternative ways of satisfying estimated needs, and the selection of an alternative are described along with the development of a plan to implement the selected alternative.

  11. Normal growth and development

    MedlinePlus

    ... DIET Poor nutrition can cause problems with a child's intellectual development. A child with a poor diet may be ... care provider if you have concerns about your child's growth and development. Related topics include: Developmental milestones record - 4 months ...

  12. Robotic Lander Development Project

    NASA Video Gallery

    The Robotic Lander Development Project at the Marshall Center is testing a prototype lander that will aid in the design and development of a new generation of small, smart, versatile robotic lander...

  13. Gammasphere software development

    SciTech Connect

    Piercey, R.B.

    1993-01-01

    Activities of the nuclear physics group are described. Progress was made in organizing the Gammasphere Software Working Group, establishing a nuclear computing facility, participating in software development at Lawrence Berkeley, developing a common data file format, and adapting the ORNL UPAK software to run at Gammasphere. A universal histogram object was developed that defines a file format and provides for an objective-oriented programming model. An automated liquid nitrogen fill system was developed for Gammasphere (110 Ge detectors comprise the sphere).

  14. PUBLISHER'S ANNOUNCEMENT: Editorial developments

    NASA Astrophysics Data System (ADS)

    2009-01-01

    We are delighted to announce that from January 2009, Professor Murray T Batchelor of the Australian National University, Canberra will be the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Murray Batchelor has been Editor of the Mathematical Physics section of the journal since 2007. Prior to this, he served as a Board Member and an Advisory Panel member for the journal. His primary area of research is the statistical mechanics of exactly solved models. He holds a joint appointment in mathematics and physics and has held visiting positions at the Universities of Leiden, Amsterdam, Oxford and Tokyo. We very much look forward to working with Murray to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Carl M Bender. Carl has done a magnificent job as Editor-in-Chief and has worked tirelessly to improve the journal over the last five years. Carl has been instrumental in designing and implementing strategies that have enhanced the quality of papers published and service provided by Journal of Physics A: Mathematical and Theoretical. Notably, under his tenure, we have introduced the Fast Track Communications (FTC) section to the journal. This section provides a venue for outstanding short papers that report new and timely developments in mathematical and theoretical physics and offers accelerated publication and high visibility for our authors. During the last five years, we have raised the quality threshold for acceptance in the journal and now reject over 60% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average less than 50 days for papers. We have recently announced another innovation; the Journal of Physics A Best Paper Prize. These prizes will honour excellent papers

  15. Dental Curriculum Development in Developing Countries.

    ERIC Educational Resources Information Center

    Phantumvanit, Prathip

    1996-01-01

    Since establishment of formal dental education in Southeast Asia, changes stemming from research and technology have led to dental curriculum changes. Development of the dental curriculum can be divided into three phases: disease oriented; health oriented; and community oriented. Evolution of these phases is traced in the dental curricula of Laos,…

  16. Essays on Child Development in Developing Countries

    ERIC Educational Resources Information Center

    Humpage, Sarah Davidson

    2013-01-01

    This dissertation presents the results of three field experiments implemented to evaluate the effectiveness of strategies to improve the health or education of children in developing countries. In Guatemala, community health workers at randomly selected clinics were given patient tracking lists to improve their ability to remind parents when their…

  17. Expanding the Professional Development School Model: Developing Collaborative Partnerships with School Counselors

    ERIC Educational Resources Information Center

    Foust, Gretchen E.; Goslee, Patricia A.

    2014-01-01

    The Professional Development School (PDS) model, a successful collaborative partnership model between university teacher education programs and P-12 schools, focuses on ''preparing future educators, providing current educators with ongoing professional development, encouraging joint school-university faculty investigation of…

  18. Cultural Energy & Grassroots Development.

    ERIC Educational Resources Information Center

    Kleymeyer, Charles D.

    1992-01-01

    Discusses how cultural vitality drives successful community development. Links cultural, community, and environmental values. Examines successes and failures of programs attempting to link culture and development in Panama, Ecuador, and Colombia. Examines role of cultural self-examination for creating new development paradigm. Examines prospects…

  19. Teachers as Course Developers.

    ERIC Educational Resources Information Center

    Graves, Kathleen, Ed.

    The collection of essays on teachers as course developers is designed to help teachers understand how to develop courses or modify existing ones using their own experience and the experiences and theories of others. It attempts to capture this process through the stories of six teachers who have developed courses. Each narrative focuses on a…

  20. Science and Development

    ERIC Educational Resources Information Center

    Auger, Pierre

    1973-01-01

    The relation between science and socioeconomic development in both developed and developing countries is discussed. The interdependence of pure and applied science, technology and finance, knowledge and tradition, and national, regional, and world-wide efforts in behalf of progress are characterized. (BL)

  1. Developing Large CAI Packages.

    ERIC Educational Resources Information Center

    Reed, Mary Jac M.; Smith, Lynn H.

    1983-01-01

    When developing large computer-assisted instructional (CAI) courseware packages, it is suggested that there be more attentive planning to the overall package design before actual lesson development is begun. This process has been simplified by modifying the systems approach used to develop single CAI lessons, followed by planning for the…

  2. Marketing Human Resource Development.

    ERIC Educational Resources Information Center

    Frank, Eric, Ed.

    1994-01-01

    Describes three human resource development activities: training, education, and development. Explains marketing from the practitioners's viewpoint in terms of customer orientation; external and internal marketing; and market analysis, research, strategy, and mix. Shows how to design, develop, and implement strategic marketing plans and identify…

  3. PHOTOGRAPHIC FILM DEVELOPER

    DOEpatents

    Berry, F.G.

    1958-06-24

    S>An improved photographic developer is presented having very high energy development fine grain characteristics and a long shelf life. These characteristics are obtained by the use of aminoacetic acid in the developer, the other constituents of which are: sodium sulfite, hydroquinone, sodiunn borate, boric acid and potassium bromide, 1-phenyl-3-pyrazolidone.

  4. Moral Development in Adolescence

    ERIC Educational Resources Information Center

    Hart, Daniel; Carlo, Gustavo

    2005-01-01

    Themes in the papers in this special issue of the "JRA" on moral development are identified. We discuss the intersection of moral development research with policy concerns, the distinctive qualities of moral life in adolescence that warrant investigation, the multiple connotations of "moral", the methods typical of moral development research, and…

  5. Bilingualism and Cognitive Development.

    ERIC Educational Resources Information Center

    Caraballo, Jose N.

    Research on the effects of bilingualism on cognitive development is reviewed, and two complementary models of bilingualism are developed to account for research results. It is suggested that research since 1960 shows a positive relationship between bilingualism and cognitive development, at least for some types of bilingualism. The advantage or…

  6. Developing Workplace Education Curriculum.

    ERIC Educational Resources Information Center

    Burkhart, Jennifer

    This guide, which is intended for project directors, coordinators, and other professional staff involved in developing/delivering workplace education programs, explains the process of developing a functional context workplace education curriculum. Discussed first are the following: the types of information needed to develop a functional context…

  7. CRITICAL READING DEVELOPS EARLY.

    ERIC Educational Resources Information Center

    LEE, DORRIS; AND OTHERS

    THIS ISSUE OF THE READING AIDS SERIES PRESENTS A DISCUSSION OF THE POTENTIAL FOR CRITICAL READING AMONG YOUNG CHILDREN AND HOW IT CAN BE DEVELOPED. IT OFFERS SUGGESTIONS FOR THE MAXIMUM DEVELOPMENT OF THINKING SKILLS AND ATTITUDES OF INQUIRY AND EVALUATION. SOME OF THE TOPICS DISCUSSED ARE -- (1) THE DEVELOPMENT OF PERCEPTS, CONCEPTS, AND COMMON…

  8. Development Communication Report, 1993.

    ERIC Educational Resources Information Center

    Bosch, Andrea, Ed.

    1993-01-01

    The three 1993 issues of the newsletter "Development Communication Report" focus on the use of communication technologies in developing countries to educate the people about various social issues as well as the field of development communication itself. Agricultural communication is the theme of the first issue which contains the following…

  9. Software development in Ada

    NASA Technical Reports Server (NTRS)

    Basili, V. R.; Katz, E. E.

    1985-01-01

    Ada will soon become a part of systems developed for the US Department of Defense. NASA must determine whether it will become part of its environment and particularly whether it will become a part fo the space station development. However, there are several issues about Ada which should be considered before this decision is made. One means of considering these issues is the examination of other developments in Ada. Unfortunately, few full scale developments have been completed or made publicly available for observation. Therefore, it will probably be necessary to study an Ada development in a NASA environment. Another means related to the first is the development of Ada metrics which can be used to characterize and evaluate Ada developments. These metrics need not be confined to full scale developments and could be used to evaluate on going projects as well. An early development in Ada, some observations from that development, metrics which were developed for use with Ada, and future directions for research into the use of Ada in software development in general and in the NASA Goddard environment in particular are described.

  10. Molecular biology of development

    SciTech Connect

    Davidson, E.H.; Firtel, R.A.

    1984-01-01

    This book is a compilation of papers presented at a symposium on the molecular biology of development. Topics discussed include: cytoplasmic localizations and pattern formations, gene expression during oogenesis and early development, developmental expression of gene families molecular aspects of plant development and transformation in whole organisms and cells.

  11. World Development Report 1984.

    ERIC Educational Resources Information Center

    World Bank, Washington, DC.

    This report, seventh in a series of annual publications, examines the relationship between population change and development, showing why continuing rapid population growth in developing countries is likely to mean a lower quality of life for millions of people. The first part of the report concludes that the economies of developing countries can…

  12. Curriculum Development in Geomorphology.

    ERIC Educational Resources Information Center

    Gregory, Kenneth J.

    1988-01-01

    Examines the context of present curriculum development in geomorphology and the way in which it has developed in recent years. Discusses the content of the geomorphology curriculum in higher education and the consequences of curriculum development together with a consideration of future trends and their implications. (GEA)

  13. Language and Psychological Development.

    ERIC Educational Resources Information Center

    Gleason, Jean Berko

    Input language may have an effect on child development that goes far beyond language development alone. Language is the medium by which children acquire at least a portion of their sex role and social class or group characteristics, world view, and emotional and psychological well-being. Existing theories of psychological development ignore…

  14. Prodder's Development Annual, 1988.

    ERIC Educational Resources Information Center

    van der Kooy, R. J. W., Ed.

    This collection of reports examines the current state of development in southern Africa, in general, and in South Africa, in particular. The introduction, "A Development Perspective of Southern Africa" (R. J. W. van der Kooy), briefly reviews the history of southern African development, and discusses purposes, approaches, and progress. Sixteen…

  15. Mechanisms in Plant Development

    SciTech Connect

    Hake, Sarah

    2013-08-21

    This meeting has been held every other year for the past twenty-two years and is the only regularly held meeting focused specifically on plant development. Topics covered included: patterning in developing tissues; short and long distance signaling; differentiation of cell types; the role of epigenetics in development; evolution; growth.

  16. Redefining Professional Development. Newsletter

    ERIC Educational Resources Information Center

    Center for Comprehensive School Reform and Improvement, 2006

    2006-01-01

    The research on effective professional development is consistent across many studies. Researchers Willis Hawley and Linda Valli (Westchester Institute for Human Services Research, n.d.), in their synthesis of the professional development literature, find that high-quality teacher development is as follows: (1) Informed by research on teaching and…

  17. Beyond Curriculum Development.

    ERIC Educational Resources Information Center

    Schutz, Richard R.

    The methodology of research and the technology of development in education have advanced beyond "curriculum development," as activities associated with that rubric are popularly practiced. These advances provide the experiential basis for five actionable conclusions: (1) Programmatic development of integrated resources for use by students,…

  18. Site Development Planning Handbook

    SciTech Connect

    1981-01-01

    The Handbook provides facility managers and site planners at DOE organizations responsible for planning site developments and facilities utilization a step-by-step planning checklist to ensure that planners at each site are focusing on Department-wide goals and objectives. It begins with a brief discussion of a site development-by-objectives program design to promote, recognize, and implement opportunities for improvements in site utilization through planning. Additional information is included on: assembling existing data, plans, programs, and procedures; establishing realistic objectives; identifying site problems, opportunities; and development needs; determining priorities among development needs; developing short and long-range plans; choosing the right development solutions and meeting minimum legal site restrictions; presenting the plan; implementing elements of the plan; monitoring and reporting plan status; and modifying development program plans. (MCW)

  19. The Computerized Adaptive Testing System Development Project.

    ERIC Educational Resources Information Center

    McBride, James R.; Sympson, J. B.

    The Computerized Adaptive Testing (CAT) project is a joint Armed Services coordinated effort to develop and evaluate a system for automated, adaptive administration of the Armed Services Vocational Aptitude Battery (ASVAB). The CAT is a system for administering personnel tests that differs from conventional test administration in two major…

  20. Common Guidelines for Education Research and Development

    ERIC Educational Resources Information Center

    Institute of Education Sciences, 2013

    2013-01-01

    In January 2011, a Joint Committee of representatives from the U.S. Department of Education (ED) and the U.S. National Science Foundation (NSF) began work to establish cross-agency guidelines for improving the quality, coherence, and pace of knowledge development in science, technology, engineering and mathematics (STEM) education. Although the…

  1. Competency Assessment Model: Development and Verification.

    ERIC Educational Resources Information Center

    Von Fange, Theodore; Benson, Sterling

    The development of a model that would provide organized direction in describing the "competent teacher" is discussed. In a joint effort of practicing teachers and college of education personnel, the parameters for identifying behaviors of effective teachers were established. Six areas of competency were used--intellectual, personality, teaching…

  2. Symbiotic New Program Development through Marketing Research.

    ERIC Educational Resources Information Center

    Urban, David J.; And Others

    1993-01-01

    The applicability of marketing research to development of college programs in collaboration with other institutions or individuals is discussed. It is recommended that college administrators conduct ongoing environmental scanning to identify major opportunities for joint programs, forming research groups to screen basic ideas and explore program…

  3. ICPP Waste Management Technology Development Program

    SciTech Connect

    Hogg, G.W.; Olson, A.L.; Knecht, D.A.; Bonkoski, M.J.

    1993-01-01

    As a result of the decision to curtail reprocessing at the Idaho Chemical Processing Plant (ICPP), a Spent fuel and Waste Management Technology Development plan has been implemented to identify acceptable options for disposing of the (1) sodium-bearing liquid radioactive waste, (2) radioactive calcine, and (3) irradiated spent fuel stored at the Idaho National Engineering Laboratory (INEL). The plan was developed jointly by DOE and WINCO.

  4. The IAU Office of Astronomy for Development

    NASA Astrophysics Data System (ADS)

    Govender, Kevin

    2015-03-01

    On 16 April 2011 the IAU's Office of Astronomy for Development (OAD) was launched jointly by the President of the IAU and the South African Minister of Science and Technology, at the South African Astronomical Observatory in Cape Town. This OAD was set up to realise the IAU's strategic plan which aims to use astronomy as a tool for development. Communicating astronomy with the public is one of the OAD's focus areas.

  5. Butt Joint Tool Commissioning

    SciTech Connect

    Martovetsky, N N

    2007-12-06

    ITER Central Solenoid uses butt joints for connecting the pancakes in the CS module. The principles of the butt joining of the CICC were developed by the JAPT during CSMC project. The difference between the CSMC butt joint and the CS butt joint is that the CS butt joint is an in-line joint, while the CSMC is a double joint through a hairpin jumper. The CS butt joint has to carry the hoop load. The straight length of the joint is only 320 mm, and the vacuum chamber around the joint has to have a split in the clamp shell. These requirements are challenging. Fig.1 presents a CSMC joint, and Fig.2 shows a CS butt joint. The butt joint procedure was verified and demonstrated. The tool is capable of achieving all specified parameters. The vacuum in the end was a little higher than the target, which is not critical and readily correctable. We consider, tentatively that the procedure is established. Unexpectedly, we discover significant temperature nonuniformity in the joint cross section, which is not formally a violation of the specs, but is a point of concern. All testing parameters are recorded for QA purposes. We plan to modify the butt joining tool to improve its convenience of operation and provide all features necessary for production of butt joints by qualified personnel.

  6. Employees, Careers, and Job Creation: Developing Growth-Oriented Human Resource Strategies and Programs. First Edition. A Joint Publication in the Jossey-Bass Management Series and the Jossey-Bass Social and Behavioral Science Series.

    ERIC Educational Resources Information Center

    London, Manuel, Ed.

    The 13 chapters in this volume detail how industrial and organizational psychologists, human resource professionals, and consultants have created innovative human resource development and training programs. "Employee Development and Job Creation" (Jennifer Jarratt, Joseph F. Coates) looks at several trends that have important consequences for…

  7. Affordable, Robust Ceramic Joining Technology (ARCJoint) Developed

    NASA Technical Reports Server (NTRS)

    Steele, Gynelle C.

    2001-01-01

    Affordable, Robust Ceramic Joining Technology (ARCJoint) is a method for joining high temperature- resistant ceramic pieces together, establishing joints that are strong, and allowing joining to be done in the field. This new way of joining allows complex shapes to be formed by joining together geometrically simple shapes. The joining technology at NASA is one of the enabling technologies for the application of silicon-carbide-based ceramic and composite components in demanding and high-temperature applications. The technology is being developed and tested for high-temperature propulsion parts for aerospace use. Commercially, it can be used for joining ceramic pieces used for high temperature applications in the power-generating and chemical industries, as well as in the microelectronics industry. This innovation could yield big payoffs for not only the power-generating industry but also the Silicon Valley chipmakers. This technology, which was developed at the NASA Glenn Research Center by Dr. Mrityunjay Singh, is a two-step process involving first using a paste to join together ceramic pieces and bonding them by heating the joint to 110 to 120 C for between 10 and 20 min. This makes the joint strong enough to be handled for the final joining. Then, a silicon-based substance is applied to the joint and heated to 1400 C for 10 to 15 min. The resulting joint is as strong as the original ceramic material and can withstand the same high temperatures.

  8. Geothermal energy development

    SciTech Connect

    Butler, E.W.; Pick, J.B.

    1983-01-01

    This book studies the impact of geothermal energy development in Imperial County, California. An integrated assessment model for public policy is presented. Geothermal energy resources in Imperial County are identified. Population and employment studies project the impact of geothermal on demography and population movement in the county. A public opinion, and a leadership opinion survey indicate support for well-regulated geothermal development. Actual development events are updated. Finally, research conclusions and policy recommendations are presented.

  9. Fusion development and technology

    SciTech Connect

    Montgomery, D.B.

    1992-01-01

    This report discusses the following: superconducting magnet technology; high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies--aries; ITER physics: alpha physics and alcator R D for ITER; lower hybrid current drive and heating in the ITER device; ITER superconducting PF scenario and magnet analysis; ITER systems studies; and safety, environmental and economic factors in fusion development.

  10. Composite Tank Development

    NASA Technical Reports Server (NTRS)

    DeLay, Thomas K.

    2000-01-01

    This paper presents viewgraphs on composite tank development. There is a need for oxidizer tanks and reliable, lightweight fuel. The need for cost-effective and scalable manufacturing is also evident. In order to achieve these goals, tooling methods for tank development must be applied, methods for producing easily adaptable and scalable vessel liners must be developed, insulation layer or protective barriers for containers must be manufactured, and an appropriate fiber/resin system for composite overwrap structures must be identified.

  11. Climate and development

    SciTech Connect

    Biswas, A.K.

    1984-01-01

    The authors review the existing knowledge on the inter-relationships between climate and patterns of development; the impact variables on water and agricultural development; and the effects of climate on human health. A case study is also given of the effect of climatic fluctuations on human population in Mesopotamia. Contents: Climate and Development; Climate and Agriculture; Climate and Water Management; Climate and Health; Effects of Climate Fluctation on Human Populations; Study of Mesopotamian Society.

  12. Renewable energy project development

    SciTech Connect

    Ohi, J.

    1996-12-31

    The author presents this paper with three main thrusts. The first is to discuss the implementation of renewable energy options in China, the second is to identify the key project development steps necessary to implement such programs, and finally is to develop recommendations in the form of key issues which must be addressed in developing such a program, and key technical assistance needs which must be addressed to make such a program practical.

  13. Blind shaft development

    SciTech Connect

    Fiscor, S.

    2009-02-15

    The article discusses how Shaft Drillers International (SDI) is breaking new ground in shaft development and ground stabilization. Techniques of blind shaft drilling and raise bore shaft development developed by SDI are briefly explained. An associated company, Coastal Drilling East, deals with all types of ground improvement such as pre-grouting work for shafts, grouting of poor soil and water leaks into the mine. 3 photos.

  14. Intelligence as Developing Expertise.

    PubMed

    Sternberg

    1999-10-01

    This essay describes how intelligence can be viewed as developing expertise. The general conception of intelligence as developing expertise is described. Then research examples are given that, in conjunction, seem odd under traditional interpretations of abilities but that make sense as a whole in the context of the developing-expertise model. It is concluded that this new model offers potential for better understanding intelligence-related phenomena. Copyright 1999 Academic Press. PMID:10508532

  15. Avionics advanced development strategy

    NASA Technical Reports Server (NTRS)

    Dyer, D.

    1990-01-01

    Discussed here is the problem of how to put together an integrated, phased, and affordable avionics advanced development program that links and applies to operational, evolving, and developing programs/vehicles, as well as those in the planning phases. Collecting technology needs from individual programs/vehicles and proposed technology items from individual developers usually results in a mismatch and something that is unaffordable. A strategy to address this problem is outlined with task definitions which will lead to avionics advanced development items that will fit within an overall framework, prioritized to support budgeting, and support the scope of NASA space transportations needs.

  16. [Apoptosis during embryo development].

    PubMed

    Jezek, Davor; Kozina, Viviana

    2009-10-01

    The development of human embryo includes two essential processes, i.e., rapid mitotic activity of cells and gradual differentiation of tissues and organs. The latter process is very often characterized by extensive migration of cells from their site of origin to the site of definitive location, inductive action of the neighboring germ layers and programmed cell death (apoptosis). This paper describes examples of proliferative and apoptotic processes during the development of human embryo. The development of trilaminar germ disk, skin, gonads, central and peripheral nerve system as well as limbs provides instructive examples of how apoptosis regulates the development and differentiation of cells. PMID:19999545

  17. Exploration Technology Development & Demonstration

    NASA Video Gallery

    Chris Moore delivers a presentation from the Exploration Technology Development & Demonstration (ETDD) study team on May 25, 2010, at the NASA Exploration Enterprise Workshop held in Galveston, TX....

  18. Shoulder Joint For Protective Suit

    NASA Technical Reports Server (NTRS)

    Kosmo, Joseph J.; Smallcombe, Richard D.

    1994-01-01

    Shoulder joint allows full range of natural motion: wearer senses little or no resisting force or torque. Developed for space suit, joint offers advantages in protective garments for underwater work, firefighting, or cleanup of hazardous materials.

  19. Development of Global Change Research in Developing Countries

    NASA Astrophysics Data System (ADS)

    Sierra, Carlos A.; Yepes, Adriana P.

    2010-10-01

    Ecosystems and Global Change in the Context of the Neotropics; Medellín, Colombia, 19-20 May 2010; Research in most areas of global environmental change is overwhelmingly produced outside developing countries, which are usually consumers rather than producers of the knowledge associated with their natural resources. While there have been important recent advances in understanding the causes of global-¬scale changes and their consequences to the functioning of tropical ecosystems, there is still an important gap in the understanding of these changes at regional and national levels (where important political decisions are usually made). A symposium was held with the aim of surveying the current state of research activities in a small, developing country such as Colombia. It was jointly organized by the Research Center on Ecosystems and Global Change, Carbono and Bosques; the National University of Colombia at Medellín and the Colombian Ministry of the Environment, Housing, and Regional Development. This 2-¬day symposium gathered Colombian and international scientists involved in different areas of global environmental change, tropical ecosystems, and human societies.

  20. Sacroiliac joint imaging.

    PubMed

    Tuite, Michael J

    2008-03-01

    The sacroiliac (SI) joint has several unique anatomical features that make it one of the more challenging joints to image. The joint is difficult to profile well on radiographic views, and therefore the radiographic findings of sacroiliitis are often equivocal. Computed tomography images can usually show the findings of sacroiliitis and osteoarthritis earlier than radiographs. Magnetic resonance imaging performed with proper sequences is excellent for diagnosing even very early sacroiliitis and for following treatment response. The SI joint is often involved in patients with osteoarthritis or one of the inflammatory spondyloarthritides, most notably ankylosing spondylitis. Ankylosing spondylitis often presents with sacroiliitis, which appears as erosions, sclerosis, and joint space narrowing, eventually leading to ankylosis. Several disorders can cause sacroiliitis-like changes of the joint, including hyperparathyroidism and repetitive shear-stress injuries in athletes. The joint can become painful during pregnancy as it widens and develops increased motion, and some postpartum women develop iliac sclerosis adjacent to the joint termed osteitis condensans ilii. Another cause of SI joint pain is a disorder called sacroiliac joint dysfunction, which typically has few abnormal imaging findings. Patients with SI joint dysfunction, as well as sacroiliitis, often get relief from image-guided SI joint therapeutic injections. PMID:18382946

  1. Halbach Magnetic Rotor Development

    NASA Technical Reports Server (NTRS)

    Gallo, Christopher A.

    2008-01-01

    The NASA John H. Glenn Research Center has a wealth of experience in Halbach array technology through the Fundamental Aeronautics Program. The goals of the program include improving aircraft efficiency, reliability, and safety. The concept of a Halbach magnetically levitated electric aircraft motor will help reduce harmful emissions, reduce the Nation s dependence on fossil fuels, increase efficiency and reliability, reduce maintenance and decrease operating noise levels. Experimental hardware systems were developed in the GRC Engineering Development Division to validate the basic principles described herein and the theoretical work that was performed. A number of Halbach Magnetic rotors have been developed and tested under this program. A separate test hardware setup was developed to characterize each of the rotors. A second hardware setup was developed to test the levitation characteristics of the rotors. Each system focused around a unique Halbach array rotor. Each rotor required original design and fabrication techniques. A 4 in. diameter rotor was developed to test the radial levitation effects for use as a magnetic bearing. To show scalability from the 4 in. rotor, a 1 in. rotor was developed to also test radial levitation effects. The next rotor to be developed was 20 in. in diameter again to show scalability from the 4 in. rotor. An axial rotor was developed to determine the force that could be generated to position the rotor axially while it is rotating. With both radial and axial magnetic bearings, the rotor would be completely suspended magnetically. The purpose of this report is to document the development of a series of Halbach magnetic rotors to be used in testing. The design, fabrication and assembly of the rotors will be discussed as well as the hardware developed to test the rotors.

  2. Population, environment and development.

    PubMed

    Karkal, M

    1994-06-01

    Western development models label subsistence economies, which do not participate in the market economy on a grand scale and do not consume commodities produced for and distributed through the market, to be poor. Yet, subsistence does not always indicate a low quality of life. The Western development process has destroyed wholesome and sustainable lifestyles. In India, the Green Revolution caused many small farmers to lose their land. In comparison to traditional economies, industrial economies have longer technological chains dependent on higher energy and resource inputs and exclude large numbers of people without power to buy goods. Further, they generate new and artificial needs, necessitating increased production of industrial goods and services. They erode resource bases for survival. This erosion is marginalizing people who were traditionally in nature's economy. Developed countries did not deliver 0.15% of their GNP to development projects in developing countries as promised. The US made population growth in these countries its cause. The UN and other multinational agencies during 1962-1972, at the US's request, began to support population and family planning programs in developing countries. These countries opposed the 1st draft at the 1974 Bucharest Population Conference, but by the conference in Mexico City, most supported the need for family planning. Yet, the US politicized this conference and had a greater say in the recommendations than did developing countries. Structural adjustments and external debt repayments required of developing countries in the 1980s set them back. In fact, the number of developing countries increased from 31 to 42. The UN recognizes the right to development, but social inequalities are barriers to this right. If environmental degradation continues, poverty will only increase. Women's groups are playing a great role in preparations for the International Conference on Population and Development in Cairo in September 1994. PMID

  3. Deployable and retractable telescoping tubular structure development

    NASA Technical Reports Server (NTRS)

    Thomson, M. W.

    1994-01-01

    A new deployable and retractable telescoping boom capable of high deployed stiffness and strength is described. Deployment and retraction functions are controlled by simple, reliable, and fail-safe latches between the tubular segments. The latch and a BI-STEM (Storable Tubular Extendible Member) actuator work together to eliminate the need for the segments to overlap when deployed. This yields an unusually lightweight boom and compact launch configuration. An aluminum space-flight prototype with three joints displays zero structural deadband, low hysteresis, and high damping. The development approach and difficulties are discussed. Test results provide a joint model for sizing flight booms of any diameter and length.

  4. Guidelines for Program Development.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education and Training, Winnipeg. Literacy and Continuing Education Branch.

    This guide, which is intended to assist developers of community-based adult literacy programs in Manitoba, explains the following components of good programming and presents suggestions for integrating them into literacy provision: community outreach, program development, learner involvement, provision of appropriate staffing, use of volunteers,…

  5. Spiritual Growth and Development.

    ERIC Educational Resources Information Center

    Wakefield, Dara V.

    Spiritual living demands growth, and spiritual development has many parallels with human development. Ministers who are knowledgeable of the various stages are best prepared to assist and optimize spiritual growth. The primary benefit of nurturing believers through developmental stages is assured spiritual health and maturity in the context of a…

  6. Development Communication Report, 1992.

    ERIC Educational Resources Information Center

    Development Communication Report, 1992

    1992-01-01

    The four issues of the quarterly newsletter contained in this document focus on the use of communication technologies in developing countries to educate the people about various social issues as well as the field of development communication itself. Environment and communication is the theme of the first issue, which includes articles on…

  7. Development. Courier No. 26.

    ERIC Educational Resources Information Center

    ASPBAE Courier Service, 1982

    1982-01-01

    This journal contains a series of articles dealing with the theme of development in Asia and rural Indonesia. Included in the journal are the following articles: "Nonformal Education in Rural Areas of Developing Countries," by members of the Rural Project Team from the Centre for Continuing Education at Australian National University; "Application…

  8. Development of IVF Children.

    ERIC Educational Resources Information Center

    van Balen, Frank

    1998-01-01

    Examines physical and psychological development of children conceived through in vitro fertilization (IVF), focusing on questions related to risk of congenital defects or mental retardation and impact on the parent-child relationship. Concludes that no serious problems have arisen concerning the physical and psychological development of IVF…

  9. [Population Growth and Development].

    ERIC Educational Resources Information Center

    Clausen, A. W.

    Rapid population growth as a central development problem, the proper domain of government in reducing population growth, and effective measures which can be taken to reduce fertility are examined. Rapid population growth puts a brake on development because it exacerbates the difficult choice between higher consumption now and the investment needed…

  10. Handbook of Moral Development

    ERIC Educational Resources Information Center

    Killen, Melanie; Smetana, Judith

    2006-01-01

    The psychological study of moral development has expanded greatly, both in terms of the diversity of theoretical perspectives that are represented in the field, as well as in the range of topics that have been studied. This "Handbook of Moral Development" represents the diversity and multidisciplinary influences on current theorizing about the…

  11. Jamaica: A Development Perspective.

    ERIC Educational Resources Information Center

    Scott, Rosalind; And Others

    Jamaica is known mainly as a tourist playground and the home of Reggae music. This Jamaican teaching unit dispels stereotypes and shows Jamaica for what it really is--an economically-troubled, developing nation. The unit illustrates the challenges this island nation is facing in its struggle toward economic development. Contents are: Teacher…

  12. Youth Development: Maori Styles

    ERIC Educational Resources Information Center

    Ware, Felicity; Walsh-Tapiata, Wheturangi

    2010-01-01

    Despite the innovative approach of the Youth Development Strategy Aotearoa and the applicability of its Rangatahi Development Package, the diverse realities and experiences of Maori youth are still presenting unique challenges to national policy in Aotearoa New Zealand. A Maori youth research approach that utilised a combination of action research…

  13. Developing Young Investigators

    ERIC Educational Resources Information Center

    Shaw, Liz; Woodbridge, Jenny; Pearson, Sue

    2003-01-01

    The Early Excellence centre was established in 1999 to undertake early years curriculum development in the North West, Yorkshire and Humberside regions. As part of development work, small research projects are commissioned in early years settings. This article describes how the authors worked with Wingate Community Nursery School. The work was…

  14. Technical Assistance to Developers

    SciTech Connect

    Rockward, Tommy; Borup, Rodney L.; Garzon, Fernando H.; Mukundan, Rangachary; Spernjak, Dusan

    2012-07-17

    This task supports the allowance of technical assistance to fuel-cell component and system developers as directed by the DOE. This task includes testing of novel materials and participation in the further development and validation of single cell test protocols. This task also covers technical assistance to DOE Working Groups, the U.S. Council for Automotive Research (USCAR) and the USCAR/DOE Driving Research and Innovation for Vehicle efficiency and Energy sustainability (U.S. Drive) Fuel Cell Technology Team. Assistance includes technical validation of new fuel cell materials and methods, single cell fuel cell testing to support the development of targets and test protocols, and regular advisory participation in other working groups and reviews. This assistance is made available to PEM fuel cell developers by request and DOE Approval. The objectives are to: (1) Support technically, as directed by DOE, fuel cell component and system developers; (2) Assess fuel cell materials and components and give feedback to developers; (3) Assist the DOE Durability Working Group with the development of various new material durability Testing protocols; and (4) Provide support to the U.S. Council for Automotive Research (USCAR) and the USCAR/DOE Fuel Cell Technology Team. FY2012 specific technical objectives are: (1) Evaluate novel MPL materials; (2) Develop of startup/ shutdown protocol; (3) Test the impact of hydrophobic treatment on graphite bi-polar plates; (4) Perform complete diagnostics on metal bi-polar plates for corrosion; and (5) Participate and lead efforts in the DOE Working Groups.

  15. Developing Environmental Study Areas.

    ERIC Educational Resources Information Center

    Wert, Jonathan M.

    This publication is designed to help the teacher in developing environmental study areas. Numerous examples of study areas, including airports, lakes, shopping centers, and zoos, are listed. A current definition of environmental study areas is given and guidelines for their development and identification are included. The appendix, which comprises…

  16. Developing Successful Global Leaders

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    Everyone seems to agree the world desperately needs strong leaders who can manage a global workforce and all the inherent challenges that go with it. That's a big part of the raison d'etre for global leadership development programs. But are today's organizations fully utilizing these programs to develop global leaders, and, if so, are they…

  17. VOCABULARY AND CONCEPT DEVELOPMENT.

    ERIC Educational Resources Information Center

    LANGER, JOHN H.

    THE PROCESSES OF THOUGHT, OF CONCEPT DEVELOPMENT, AND OF VOCABULARY DEVELOPMENT ARE SIGNIFICANTLY INTERRELATED. COMMUNICATION OF IDEAS DEPENDS UPON THE ABILITY TO ASSOCIATE WRITTEN AND VERBAL SYMBOLS WITH THE REFERENTS THROUGH A SYSTEMATIC PROCESS OF REORGANIZING AND INTEGRATING OLD AND NEW CONCEPTS. THE ABILITY TO ASSOCIATE, IN TURN, DEPENDS UPON…

  18. Strengthening Evaluation for Development

    ERIC Educational Resources Information Center

    Ofir, Zenda

    2013-01-01

    Although some argue that distinctions between "evaluation" and "development evaluation" are increasingly superfluous, it is important to recognize that some distinctions still matter. The severe vulnerabilities and power asymmetries inherent in most developing country systems and societies make the task of evaluation…

  19. PLATO Courseware Development Procedures.

    ERIC Educational Resources Information Center

    Mahler, William A.; And Others

    This is an exploratory study of methods for the preparation of computer curriculum materials. It deals with courseware development procedures for the PLATO IV computer-based education system, and draws on interviews with over 100 persons engaged in courseware production. The report presents a five stage model of development: (1) planning, (2)…

  20. Steps in Intrauterine Development.

    ERIC Educational Resources Information Center

    Barra, H. Gensini; And Others

    1996-01-01

    Recognizing the importance of health care during the perinatal period, the topic for this issue of "Children in the Tropics" is prenatal development; this issue is intended for health educators for use in educating their clients about prenatal development, health care during pregnancy, labor and delivery, and the needs of the mother and neonate…