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1

Parkinson's Disease  

MedlinePLUS

... Brain Stimulation Consortium Meeting Summary Parkinson's Disease Cell Biology Meeting Summary Parkinson's Disease Cell Biology Meeting Summary Udall Centers Meeting—Expediting Parkinson’s Disease ...

2

Pick disease  

MedlinePLUS

Semantic dementia; Dementia - semantic; Frontotemporal dementia; Arnold Pick disease ... can help doctors tell Pick disease apart from Alzheimer disease. (Memory loss is often the main, and earliest, ...

3

Lentil Diseases  

Technology Transfer Automated Retrieval System (TEKTRAN)

Major lentil diseases around the world have been described and reviewed. The major diseases include Ascochyta blight, Fusarium wilt, Botrytis Gray Mold, Lentil rust, Stemphylium blight, Anthracnose, and virus diseases. The management practices for these diseases are also presented....

4

Meningococcal Disease  

MedlinePLUS

... Disease Mumps Pertussis (Whooping Cough) Pneumococcal Disease Rubella (German Measles) Shingles (Herpes Zoster) Tetanus (Lockjaw) Professional Resources ... Disease Mumps Pertussis (Whooping Cough) Pneumococcal Disease Rubella (German Measles) Shingles (Herpes Zoster) Tetanus (Lockjaw) You May ...

5

Lyme Disease  

MedlinePLUS

... Is Lyme Disease? People get Lyme disease through tick bites. The disease is caused by a bacterium called ... a sesame seed. It's easy to overlook a tick bite. Many people who get Lyme disease don't ...

6

Chagas Disease  

MedlinePLUS

... Health Division of Parasitic Diseases and Malaria CS226359 Chagas Disease Fact Sheet What is Chagas disease? ? A disease that can cause serious heart ... benchuca,” “vinchuca,” “chinche,” or “barbeiro” Who can get Chagas disease? Anyone. However, people have a greater chance ...

7

VESICULAR DISEASES  

Technology Transfer Automated Retrieval System (TEKTRAN)

The principal vesicular diseases that affect swine are foot-and-mouth disease (FMD), vesicular stomatitis (VS), and swine vesicular diseases (SVD). There are other infectious diseases and conditions that can produce signs and pathologies in pigs similar to those seen in these three viral diseases, ...

8

Alzheimer's Disease  

MedlinePLUS

... version of this page please turn Javascript on. Alzheimer's Disease What Is Alzheimer's Disease? Alzheimer’s disease is a brain disease that slowly ... it has no cure. A Common Cause of Dementia Alzheimer’s disease is the most common cause of ...

9

Foodborne Diseases  

MedlinePLUS

... JavaScript on. Read more information on enabling JavaScript. Foodborne Diseases Top Banner Content Area Skip Content Marketing Share ... on a clean kitchen countertop. Credit: CDC. Understanding Foodborne Diseases Infectious diseases spread through food or beverages are ...

10

Crohn's Disease  

MedlinePLUS

Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory ... small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an ...

11

Alzheimer's Disease  

MedlinePLUS

Alzheimer's disease (AD) is the most common form of dementia among older people. Dementia is a brain disorder that ... higher if a family member has had the disease. No treatment can stop the disease. However, some ...

12

Infectious Diseases  

MedlinePLUS

Infectious diseases kill more people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living ... live NIH: National Institute of Allergy and Infectious Diseases

13

Bone Diseases  

MedlinePLUS

... break Osteogenesis imperfecta makes your bones brittle Paget's disease of bone makes them weak Bone disease can make bones easy to break Bones can also develop cancer and infections Other bone diseases are caused by poor nutrition, genetic factors or ...

14

Behcet's Disease  

MedlinePLUS

... Old Silk Route,” which spans the region from Japan and China in the Far East to the ... the disease’s epidemiology is not well understood. In Japan, Behcet’s disease ranks as a leading cause of ...

15

Parkinson's Disease  

MedlinePLUS

... symptoms of something called Parkinson's disease. What Is Parkinson's Disease? You may have seen the actor Michael J. ... it needs to move normally. Continue What Causes Parkinson's Disease? Experts agree that low dopamine levels in the ...

16

Reportable diseases  

MedlinePLUS

... be reported to the U.S. Centers for Disease Control and Prevention (CDC). Reportable diseases are divided into several groups: Mandatory written reporting: A report of the disease must be made ...

17

Pompe Disease  

MedlinePLUS

... Manifestations of Pompe Disease, Acid Maltase Deficiency, Glycogen Storage Disease Table of Contents (click to jump to ... Clinical Trials Organizations Column1 Column2 Association for Glycogen Storage Disease P.O. Box 896 Durant, IA 52747 ...

18

Lyme Disease  

MedlinePLUS

... Lyme Disease Top Banner Content Area Skip Content Marketing Share this: Main Content Area Understanding Lyme Disease ... about NIAID Lyme disease research . Research at NIAID Diagnostic Research Co-Infection Antibiotic Therapy Vaccines Research in ...

19

Farber's Disease  

MedlinePLUS

... a group of inherited metabolic disorders called lipid storage diseases, in which excess amounts of lipids (oils, ... Institutes of Health (NIH), conducts research about lipid storage diseases such as Farber’s disease in laboratories at ...

20

Huntington's Disease  

MedlinePLUS

Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. ... express emotions. If one of your parents has Huntington's disease, you have a 50 percent chance of getting ...

21

Krabbe Disease  

MedlinePLUS

... Krabbe Disease? Krabbe disease is a rare, inherited degenerative disorder of the central and peripheral nervous systems. ... receive umbilical cord blood stem cells prior to disease onset or early bone marrow transplantation. Persons with juvenile- or adult-onset ...

22

Bladder Diseases  

MedlinePLUS

... frequent, urgent urination Bladder cancer Doctors diagnose bladder diseases using different tests. These include urine tests, x- ... National Institute of Diabetes and Digestive and Kidney Diseases

23

Newcastle disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Newcastle disease (ND), referred to as Exotic Newcastle disease (END) in the U. S., is an acute viral disease of domestic poultry and many other bird species and a recognized worldwide problem. Occurrence of END is due to an infection with virulent strains of Newcastle disease virus (NDV) and is a ...

24

Heart Diseases  

MedlinePLUS

... you're like most people, you think that heart disease is a problem for others. But heart disease is the number one killer in the ... of disability. There are many different forms of heart disease. The most common cause of heart disease ...

25

Prion Diseases  

Microsoft Academic Search

The modern history of the prion diseases is one of novel microbes, anthropological intrigue, and food safety mishaps. The\\u000a prion diseases, also called the transmissible spongiform encephalopathies, are fatal neurodegenerative diseases that can be\\u000a sporadic, inherited, or acquired. These multiple origins are unique among human disease. The basis of all prion diseases is\\u000a the misfolding of the host prion protein

Qingzhong Kong; Richard A. Bessen

26

Binswanger's Disease  

MedlinePLUS

... Trials Organizations What is Binswanger's Disease? Binswanger's disease (BD), also called subcortical vascular dementia , is a type ... and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern ...

27

Raynaud's Disease  

MedlinePLUS

Raynaud's disease is a rare disorder of the blood vessels, usually in the fingers and toes. It causes the ... secondary Raynaud's, which is caused by injuries, other diseases, or certain medicines. People in colder climates are ...

28

Gaucher's Disease  

MedlinePLUS

Gaucher's disease is a rare, inherited disorder in which you do not have enough of an enzyme called glucocerebrosidase. ... It usually starts in childhood or adolescence. Gaucher's disease has no cure. Treatment options for types 1 ...

29

Addison Disease  

MedlinePLUS

... blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make ... problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, ...

30

Fifth Disease  

MedlinePLUS

Fifth disease is a viral infection caused by parvovirus B19. The virus only infects humans; it's not the same parvovirus that dogs and cats can get. Fifth disease mostly affects children. Symptoms can include a low ...

31

Legionnaires' Disease  

MedlinePLUS

Legionnaires' disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from ... spread from person to person. Symptoms of Legionnaires' disease include high fever, chills, a cough, and sometimes ...

32

Parasitic Diseases  

MedlinePLUS

... a bug bite, or sexual contact. Some parasitic diseases are easily treated and some are not. Parasites ... be seen with the naked eye. Some parasitic diseases occur in the United States. Contaminated water supplies ...

33

Wilson Disease  

MedlinePLUS

Wilson disease is a rare inherited disorder that prevents your body from getting rid of extra copper. You need ... copper into bile, a digestive fluid. With Wilson disease, the copper builds up in your liver, and ...

34

Eye Diseases  

MedlinePLUS

... the back of the eye Macular degeneration - a disease that destroys sharp, central vision Diabetic eye problems ... defense is to have regular checkups, because eye diseases do not always have symptoms. Early detection and ...

35

Chagas Disease  

MedlinePLUS

Chagas disease is caused by a parasite. It is common in Latin America but not in the United States. ... nose, the bite wound or a cut. The disease can also spread through contaminated food, a blood ...

36

Parkinson's Disease  

MedlinePLUS

... and Parkinson’s disease illustrates value of exposome studies (Mar. 2014) Exploring the haunting legacy – benomyl and Parkinson’s ( ... 2011) Deciphering a Core Process in Parkinson's Disease (Mar. 2011) Workshop Examines the Role of Air Pollution ...

37

Lyme Disease  

MedlinePLUS

... wondered whether the European rash, called erythema migrans (EM), and Lyme disease might have the same cause. ... that a spirochete caused both Lyme disease and EM. The spirochete was later named Borrelia burgdorferi in ...

38

Heart Disease  

MedlinePLUS

... this? Submit What's this? Submit Button Related CDC Web Sites Division for Heart Disease and Stroke Prevention ... this? Submit What's this? Submit Button Related CDC Web Sites Division for Heart Disease and Stroke Prevention ...

39

Batten Disease  

MedlinePLUS

... The NINDS supports two national human brain specimen banks. These banks supply investigators around the world with tissue from patients with neurological and psychiatric diseases. Both banks need brain tissue from Batten disease patients to ...

40

Mycobacterial Diseases  

MedlinePLUS

... Differences Between Lab and Live Results . Related Links Tuberculosis Leprosy (Hansen's Disease) National Library of Medicine, MedlinePlus ... coats that can be found throughout the world. Tuberculosis and leprosy (Hansen’s disease) are the best known ...

41

Wildlife Diseases  

E-print Network

chronic diarrhea, abdominal cramps, bloating and fatigue. Giardiasis is not usually a life threatening disease, and once diag- nosed can be effectively treated with medication. To prevent the disease, avoid drinking or acci- dentally ingesting untreated...

Texas Wildlife Services

2007-03-13

42

Hirschsprung Disease  

MedlinePLUS

... For Kids For Parents MORE ON THIS TOPIC Digestive System Irritable Bowel Syndrome (IBS) Inflammatory Bowel Disease X- ... GI) Irritable Bowel Syndrome Inflammatory Bowel Disease Your Digestive System Constipation Upper GI (Video) Digestive System Inflammatory Bowel ...

43

Celiac Disease  

MedlinePLUS

... with celiac disease, a lifelong disorder of the digestive system, these foods aren't always the treats that ... commonly consumed ingredient. What Is Celiac Disease? The digestive system is the set of organs that digest food ...

44

Celiac Disease  

MedlinePLUS

... immune disease in which people can't eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small ...

45

Huntington disease  

MedlinePLUS

Huntington disease is a disorder in which nerve cells in certain parts of the brain waste away, or ... Huntington disease is caused by a genetic defect on chromosome 4. The defect causes a part of DNA, ...

46

Fifth Disease  

MedlinePLUS

... Search The CDC Cancel Submit Search The CDC Parvovirus B19 and Fifth Disease Note: Javascript is disabled ... message, please visit this page: About CDC.gov . Parvovirus Home About Parvovirus B19 Fifth Disease Pregnancy and ...

47

Fifth disease  

MedlinePLUS

Parvovirus B19; Erythema infectiosum; Slapped cheek rash ... Fifth disease is caused by human parvovirus B19. It often affects preschoolers or school-age children during the spring. The disease spreads through the fluids in the nose and ...

48

Leigh's Disease  

MedlinePLUS

... Leigh's disease can be caused by mutations in mitochondrial DNA or by deficiencies of an enzyme called pyruvate ... kidney function. In Leigh’s disease, genetic mutations in mitochondrial DNA interfere with the energy sources that run cells ...

49

Alexander Disease  

MedlinePLUS

... may be other genetic or perhaps even non-genetic causes of Alexander disease. Current research is aimed at understanding the mechanisms by which the mutations cause disease, developing better animal models for the disorder, and exploring potential strategies ...

50

Lyme Disease  

MedlinePLUS

Lyme disease is a bacterial infection you get from the bite of an infected tick. The first symptom ... Muscle and joint aches A stiff neck Fatigue Lyme disease can be hard to diagnose because you may ...

51

Behcet's Disease  

MedlinePLUS

... other diseases of the digestive tract, such as ulcerative colitis and Crohn’s disease, careful evaluation is essential to ... is put directly on the affected body part. Ulcerative colitis. Inflammation of the colon. Symptoms include stomach pain ...

52

Autoimmune Diseases  

MedlinePLUS

... of the digestive tract. Crohn's (krohnz) disease and ulcerative colitis (UHL-sur-uh-tiv koh-LEYE-tuhss) are ... Crohn's disease) Painful or difficult bowel movements (in ulcerative colitis) Inflammatory myopathies (meye-OP-uh-theez) A group ...

53

Neurodegenerative Diseases  

Microsoft Academic Search

The neurodegenerative disorders, which include Amyotrophic Lateral Sclerosis (ALS), Alzheimer Disease (AD), Parkinson Disease\\u000a (PD), and Huntington Disease (HD), are clinically heterogeneous. Medications can ameliorate some symptoms, but none reverse\\u000a the relentless progression of the illnesses. The past several decades have seen a dramatic increase in the understanding of\\u000a the complex pathophysiology underlying the diseases. Overlapping features at the cellular

Jinsy A. Andrews; Paul H. Gordon

54

Prion diseases  

Microsoft Academic Search

Human prion diseases are a rare and diverse group of neurodegenerative diseases that have long provoked interest from physicians and scientists. Initially, this related to the enigma of a group of diseases with inherited, sporadic and acquired forms, and then subsequently to the proposition that the infectious agent comprised an abnormally folded but widely expressed cell-surface protein. More recently, the

Diego Kaski; Simon Mead

2009-01-01

55

Prion diseases  

Microsoft Academic Search

Human prion diseases are a rare and diverse group of neurodegenerative diseases that have long provoked interest from physicians and scientists. Initially, this related to the enigma of a disease with inherited, sporadic and acquired forms, and the subsequent demonstration that the infectious agent comprised an abnormally folded but widely expressed cell-surface protein. More recently, the epidemic of bovine spongiform

Simon Mead

2005-01-01

56

Celiac Disease  

MedlinePLUS

... absorbing enough iron. Continue Why Do Kids Get Celiac Disease? No one is sure why celiac disease happens, but it appears to run in families. ... have a 5% to 10% chance of getting celiac disease if someone in your family has it. It's ...

57

Kawasaki disease  

PubMed Central

Short history of Kawasaki disease, clinical features (principal symptoms and other significant symptoms or findings), diagnosis, cardiovascular involvement, epidemiology. Pathological features (lesion of vessels and lesion of organs exclusive of vessels), comparison between infantile periarteritis nodosa (IPN)/Kawasaki disease and classic periarteritis nodosa (CPN), etiology, treatment and management of Kawasaki disease are described.

Kawasaki, Tomisaku

2006-01-01

58

Sandhoff Disease  

MedlinePLUS

... body. Sandhoff disease is a severe form of Tay-Sachs disease--which is prevalent primarily in people of Eastern ... Worldwide NINDS Clinical Trials Organizations Column1 Column2 National Tay-Sachs and Allied Diseases Association 2001 Beacon Street Suite 204 Boston, MA ...

59

Crinkle Disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Crinkle disease of hop was first described in Europe in 1930, and subsequent reports of the disease appear in literature published in the 1960s and 1970s. The disease appears to be of little importance in most regions of hop production. A fastidious rickettsia-like organism (RLO) is thought to cau...

60

NEWCASTLE DISEASE  

Technology Transfer Automated Retrieval System (TEKTRAN)

Concise information about Newcastle disease (ND) is provided for a book that serves as a quick reference guide to the infectious, parasitic, metabolic, nutritional, and toxic diseases of domesticated animals and birds as well some exotic species that a veterinarian might encounter. Newcastle disease...

61

Meniere's Disease.  

ERIC Educational Resources Information Center

Meniere's disease is characterized by unpredictable spells of severe vertigo and fluctuations in hearing and tinnitus. This article discusses the incidence of Meniere's disease, the present status of our understanding of this disease, controversies in its diagnosis, and the multiple therapeutic modalities recruited in its treatment. (Contains…

Schessel, David A.

1997-01-01

62

Lyme Disease  

MedlinePLUS

... Most cases of Lyme disease occur in the spring and summer months. Lyme disease, in most cases, can be eliminated with antibiotics, especially if treatment is started when symptoms are first noted. Lyme disease is divided into 3 phases: Early localized : Symptoms start a few days to a ...

63

Prostate Diseases  

MedlinePLUS

Aging & Health A to Z Prostate Diseases Basic Facts & Information What are Prostate Diseases? The prostate—one of the components of a man's sex organs—is a ... out anything serious. The Most Common Types of Prostate Diseases Benign prostatic hyperplasia (BPH) Prostatitis Prostate cancer ...

64

Lyme Disease.  

ERIC Educational Resources Information Center

This overview of the public health significance of Lyme disease includes the microbiological specifics of the infectious spirochete, the entomology and ecology of the ticks which are the primary disease carrier, the clinical aspects and treatment stages, the known epidemiological patterns, and strategies for disease control and for expanded public…

Taylor, George C.

1991-01-01

65

Crohn's Disease  

MedlinePLUS

... Crohn’s disease are very similar to those of ulcerative colitis , except that Crohn’s disease can happen anywhere along ... tract, from the mouth to the anus , while ulcerative colitis is restricted to the colon . Crohn’s disease may ...

66

Kawasaki disease.  

PubMed

Kawasaki disease (KD) is the archetypal pediatric vasculitis, exemplifying the unique aspects and challenges of vascular inflammation in children. The condition is almost unheard of in adults, is closely associated with infections, and is self-limited, with fever resolving after an average of 12 days even without treatment. Yet KD is also a potentially fatal disease and the most common cause of acquired heart disease in the developed world. Unraveling of the developmental, immunologic, and genetic secrets of Kawasaki disease promises to improve our understanding of vasculitis in particular, and perhaps also to provide a window on the fundamental mysteries of inflammatory diseases in general. PMID:25399940

Sundel, Robert P

2015-01-01

67

[Wilson's disease].  

PubMed

Wilson's disease is an autosomal recessive disorder of copper metabolism. The Wilson disease protein is a copper-transporting P-type ATPase, ATP7B, the malfunction of which results in the toxic accumulation of copper in the liver and brain, causing the hepatic and/or neurological symptoms accompanying this disease. Patients present, generally between the ages of 10 and 40 years, with liver disease, neurological disease of a movement disorder type, or behavioral abnormalities, and often with a combination of these. Because Wilson's disease is effectively treated, it is extremely important for physicians to learn to recognize and diagnose the disease. The laboratory diagnosis of Wilson's disease is confirmed by decreased serum ceruloplasmin, increased urinary copper content, and elevated hepatic copper concentration. Molecular genetic analysis is complex as more than 200 unique mutations have been identified and most individuals are compound heterozygotes. The treatment of Wilson's disease must be life long. Copper chelation with penicillamine is an effective therapy in most patients. Another chelating agent which has been used successfully as the initial therapy is trientine. The search for new anticopper drugs for Wilson's disease is culminating in two excellent new drugs: zinc for maintenance therapy and ammonium tetrathiomolybdate (which is to date still an experimental drug) for initial therapy. Liver transplantation is indicated for the fulminant form and in those patients with severe disease not responding to optimal medical management. This paper reviews the pathogenesis, pathology, clinical presentation and diagnosis of the Wilson's disease as well as the most recent views on the molecular genetics and the treatment of this disease. PMID:14582469

Kovacevi?, Igor; Zekan, Mirta

2003-01-01

68

Lyme Disease  

PubMed Central

Synopsis Lyme disease, caused by spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States. The clinical presentation varies depending on the stage of the illness: early disease includes erthyma migrans, early disseminated disease includes multiple erythema migrans, meningitis, cranial nerve palsies and carditis; late disease is primarily arthritis. The symptoms and signs of infection resolve in the vast majority of patients after appropriate treatment with antimicrobials for from 2-4 weeks. Serologic testing should be used judiciously as it often results in misdiagnosis when performed on blood from patients with a low prior probability of disease and those with non-specific symptoms such as fatigue or arthralgia without signs of infection. PMID:20513553

Murray, Thomas S.; Shapiro, Eugene D.

2013-01-01

69

Prion Diseases  

NSDL National Science Digital Library

Prion Diseases is one of a set of lecture notes for Virology 335 by Shaun Heaphy of Leicester University (UK). It contains detailed information on its topic, along with selected links. Although prion research has been going on for over 25 years, the scientific and medical communities have only recently acknowledged the existence of prions and there remains serious debate over their role in a variety of neurological diseases. The name "prion" is derived from "proteinaceous infectious particles," and was coined by Dr. Stanley Prusiner, who discovered the agents and who recently received the Nobel Prize for Medicine for his work. Prions are thought to be the first transmissible and heritable disease-causing agents that lack DNA and RNA. They are composed solely of protein and appear to be the cause of such diseases as kuru and Creutzfeldt-Jakob disease in humans, and bovine spongiform encephalopathies, mad cow disease, and scrapie in sheep and goats.

Heaphy, Shaun.

1997-01-01

70

Infectious disease  

NASA Technical Reports Server (NTRS)

This is a collection of viewgraphs on the Johnson Space Center's work on infectious disease. It addresses their major concern over outbreaks of infectious disease that could jeopardize the health, safety and/or performance of crew members engaged in long duration space missions. The Antarctic environment is seen as an analogous location on Earth and a good place to carry out such infectious disease studies and methods for proposed studies as suggested.

Pierson, Duane L.

1990-01-01

71

Gaucher disease.  

PubMed

Gaucher disease is the commonest lysosomal storage disease seen in India and worldwide. It should be considered in any child or adult with an unexplained splenohepatomegaly and cytopenia which are seen in the three types of Gaucher disease. Type 1 is the non-neuronopathic form and type 2 and 3 are the neuronopathic forms. Type 2 is a more severe neuronopathic form leading to mortality by 2 years of age. Definitive diagnosis is made by a blood test-the glucocerebrosidase assay. There is no role for histological examination of the bone marrow, liver or spleen for diagnosis of the disease. Molecular studies for mutations are useful for confirming diagnosis, screening family members and prognosticating the disease. A splenectomy should not be performed except for palliation or when there is no response to enzyme replacement treatment or no possibility of getting any definitive treatment. Splenectomy may worsen skeletal and lung manifestations in Gaucher disease. Enzyme replacement therapy (ERT) has completely revolutionized the prognosis and is now the standard of care for patients with this disease. Best results are seen in type 1 disease with good resolution of splenohepatomegaly, cytopenia and bone symptoms. Neurological symptoms in type 3 disease need supportive care. ERT is of no benefit in type 2 disease. Monitoring of patients on ERT involves evaluation of growth, blood counts, liver and spleen size and biomarkers such as chitotriosidase which reflect the disease burden. Therapy with ERT is very expensive and though patients in India have so far got the drug through a charitable access programme, there is a need for the government to facilitate access to treatment for this potentially curable disease. Bone marrow transplantation is an inferior option but may be considered when access to expensive ERT is not possible. PMID:25755533

Nagral, Aabha

2014-03-01

72

Genetic Diseases  

Microsoft Academic Search

\\u000a Many dermatologic diseases have a genetic component, and so this group of diseases may be expanded as more evidence is unearthed.\\u000a Atopic dermatitis, for instance, is currently included in the dermatitis\\/eczema group. Filaggrin gene defects have been found\\u000a in approximately 50% of the patients with atopic dermatitis, but the relationship of this defect to the pathogenesis of this\\u000a disease has

Herbert B. Allen

73

Gaucher Disease  

PubMed Central

Gaucher disease is the commonest lysosomal storage disease seen in India and worldwide. It should be considered in any child or adult with an unexplained splenohepatomegaly and cytopenia which are seen in the three types of Gaucher disease. Type 1 is the non-neuronopathic form and type 2 and 3 are the neuronopathic forms. Type 2 is a more severe neuronopathic form leading to mortality by 2 years of age. Definitive diagnosis is made by a blood test–the glucocerebrosidase assay. There is no role for histological examination of the bone marrow, liver or spleen for diagnosis of the disease. Molecular studies for mutations are useful for confirming diagnosis, screening family members and prognosticating the disease. A splenectomy should not be performed except for palliation or when there is no response to enzyme replacement treatment or no possibility of getting any definitive treatment. Splenectomy may worsen skeletal and lung manifestations in Gaucher disease. Enzyme replacement therapy (ERT) has completely revolutionized the prognosis and is now the standard of care for patients with this disease. Best results are seen in type 1 disease with good resolution of splenohepatomegaly, cytopenia and bone symptoms. Neurological symptoms in type 3 disease need supportive care. ERT is of no benefit in type 2 disease. Monitoring of patients on ERT involves evaluation of growth, blood counts, liver and spleen size and biomarkers such as chitotriosidase which reflect the disease burden. Therapy with ERT is very expensive and though patients in India have so far got the drug through a charitable access programme, there is a need for the government to facilitate access to treatment for this potentially curable disease. Bone marrow transplantation is an inferior option but may be considered when access to expensive ERT is not possible. PMID:25755533

Nagral, Aabha

2014-01-01

74

Hodgkin's disease  

SciTech Connect

The outlook for patients with Hodgkin's disease has improved dramatically over the past 20 years. The question is no longer whether cure is possible, but rather, how can cure be best achieved. With better understanding of the biology of Hodgkin's disease and with continued evolution of treatment approaches, the goal of curing all patients with Hodgkin's disease is clearly within reach. This article provides a summary of current concepts in the biology and management of Hodgkin's disease. Staging, treatment options, and complications of therapy are discussed.

Portlock, C.S.

1984-05-01

75

Disease Detective  

NSDL National Science Digital Library

This activity (on pages 35-43) lets learners analyze a "herd of elk" to detect the spread of a bacterial disease called brucellosis. The activity simulates how wildilfe veterinarians study elk in the wild by sampling only a subset of the animals. Based on a brucellosis problem with elk in Yellowstone National Park, learners cut out representations for two herds and then pick some at random to "test" for disease (denoted as a plus sign on a diseased animal). The results indicate that elk fed in Wyoming over the winter have more disease than the wild elk that go north to Montana

University of Nebraska State Museum

2002-01-01

76

Alzheimer's Disease  

Microsoft Academic Search

The proliferation of information regarding Alzheimer's disease in current years has had a tremendous impact on the literature being generated on this topic. Until fairly recently, Alzheimer's disease was believed to be incurable, and its progress inexorable. In recent years research has come up with encouraging results which give hope that new treatments and even a cure is possible in

Carol Gillen

1993-01-01

77

Cardiovascular Disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Cardiovascular disease (CVD), particularly CHD (coronary heart disease) and stroke, remain the leading causes of death of women in America and most developed countries. In recent years the rate of CVD has declined in men but not in women. This is contributed to by an under-recognition of women’s C...

78

Addison's Disease  

MedlinePLUS

... is Addison’s disease? Addison’s disease affects your body’s adrenal glands. The adrenal glands are part of the endocrine system. The endocrine ... your moods, growth, metabolism, and tissue function. The adrenal glands are located just above your kidneys. They produce ...

79

Mitochondrial Diseases  

PubMed Central

Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Although several proteins related with signalling, assembling, transporting, and enzymatic function can be impaired in mitochondrial diseases, most frequently the activity of the respiratory chain protein complexes is primarily or secondarily affected, leading to impaired oxygen utilization and reduced energy production. Mitochondrial diseases usually show a chronic, slowly progressive course and present with multiorgan involvement with varying onset between birth and late adulthood. Neuromuscular system is frequently affected in mitochondrial diseases. Although there is actually no specific therapy and cure for mitochondrial diseases, the understanding of the pathophysiology may further facilitate the diagnostic approach and open perspectives to future in mitochondrial diseases. PMID:24649452

Lee, Young-Mock

2012-01-01

80

[Graves' disease].  

PubMed

Genetic and environmental determinants inducing Graves' disease are still poorly defined, especially those leading to the appearance of TSH receptor antibodies, which are both the hallmark of the disease and the keystone of its diagnosis. The treatment of Graves' disease is based on the use of antithyroid drugs and no therapeutic protocol has proven superior to the other. Surgical or radiometabolic treatments, largely restricted to relapses and to patients with comorbidities could be considered earlier provided we had reliable predictive markers for relapse. The treatment of Graves' orbitopathy relies first on a rigorous analysis of severity and activity of the disease. Intravenous steroids appear as a reference treatment in active forms. Evaluation of new therapeutics is in process. Graves' disease during pregnancy requires a multidisciplinary approach and an expert ultrasound evaluation of the fetus. Because of a suspected teratogenicity of carbimazole and methimazole, propylthiouracyl is the preferred drug used during early pregnancy. PMID:25090772

Illouz, Frédéric; Rodien, Patrice

2014-06-01

81

Beryllium disease.  

PubMed Central

The increasing use of beryllium in a variety of industries continues to be a hazard. New cases are still being reported to the UK Beryllium Case Registry, now numbering 60 in the period 1945-1988. The majority of cases follow inhalation which results in acute beryllium disease (chemical pneumonitis) or more commonly chronic beryllium disease--a granulomatous pneumonitis. Granulomatous skin nodules also occur following local implantation. The clinical and radiological features are briefly described with the emphasis on pathology and immunology. Laser microprobe mass spectrometry analysis of tissue sections is a major advance in diagnosis. Detection of beryllium distinguishes the granulomas of chronic beryllium disease from other diseases, in particular sarcoidosis. The role of beryllium lymphocyte transformation tests is discussed. Chronic beryllium disease is steroid dependent and local excision of skin lesions appears to be curative. There is no evidence that beryllium is carcinogenic. Images Figure 1 PMID:3074283

Jones Williams, W.

1988-01-01

82

[Peyronie's disease].  

PubMed

Peyronie's disease is caused by collagen deposits in the tunica albuginea of the corpus cavernosum following microtrauma. Symptoms may include a combination of penile curvature, a palpable plaque, painful erections and erectile dysfunction. Peyronie's disease can have a major impact on the quality of life. In the course of the disease two phases can be discerned. In the first, active phase there is penile curvature with painful erections. The second, stable phase is characterised by painless curvature of the penis. Treatment in the active phase is conservative and supportive. Surgical treatment is useful only in the stable phase and may consist of penile plication surgery or penile graft surgery. PMID:25004781

Ruiter, Annebeth E C; Meuleman, Eric J H

2014-01-01

83

Gaucher's disease  

PubMed Central

Gaucher's disease (GD) is the most common amongst the various disorders classified under the lysosomal storage disorders. GD is a model for applications of molecular medicine to clinical delineation, diagnosis, and treatment. The multiorgan and varied presentation of the disease makes it a challenge to diagnose GD early. The advent of enzyme replacement therapy in the early 1990s changed the management, and survival, of patients with GD. In addition to this, development of substrate reduction, pharmacological chaperone, and gene therapies has broadened the horizon for this rare disease. However, in resource-poor countries like ours, optimal management is still a distant dream. PMID:21897894

Bohra, Vijay; Nair, Velu

2011-01-01

84

Leishmaniasis Disease  

MedlinePLUS

... message, please visit this page: About CDC.gov . Parasites - Leishmaniasis Parasites Home Share Compartir Disease Ulcerative skin lesion, with ... with some of the species (types) of the parasite that cause cutaneous leishmaniasis in parts of Latin ...

85

Celiac Disease  

Microsoft Academic Search

Celiac disease is induced by the ingestion of gluten, which is derived from wheat, barley, and rye. The gluten protein is enriched in glutamine and proline and is poor- ly digested in the human upper gastrointestinal tract. The term \\

Peter H. R. Green; Christophe Cellier

2007-01-01

86

Kennedy's Disease  

MedlinePLUS

... of a group of disorders called lower motor neuron disorders (which involve disruptions in the transmission of nerve cell signals in the brain to nerve cells in the brain stem and spinal cord). Onset of the disease is ...

87

Meniere's Disease  

MedlinePLUS

... pressure in some cases of Méničre?s disease. The auditory brain stem response (ABR), a computerized test of ... has advantages and drawbacks. In many people, careful control of salt in the diet and the use ...

88

Menkes Disease  

MedlinePLUS

... defective gene named ATPTA 1 that regulates the metabolism of copper in the body. The disease primarily affects male infants. Copper accumulates at abnormally low levels in the liver and brain, but at higher than normal levels ...

89

Alzheimer's Disease  

MedlinePLUS

... progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry ... people. Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—and behavioral abilities, to such ...

90

Canavan Disease  

MedlinePLUS

... brain responsible for making myelin sheaths, known as oligodendrocytes, cannot properly complete this critical developmental task. Myelin ... support for nerve cells. In Canavan disease, many oligodendrocytes do not mature and instead die, leaving nerve ...

91

Liver Diseases  

MedlinePLUS

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. There are many kinds of liver diseases. Viruses cause some of them, like hepatitis ...

92

Behcet's Disease  

MedlinePLUS

... of Behcet's disease include recurrent ulcers in the mouth (resembling canker sores) and on the genitals, and eye inflammation. The disorder may also cause various types of skin lesions, arthritis, bowel inflammation, meningitis (inflammation of the membranes ...

93

Meniere's disease.  

PubMed

Meniere's disease is a chronic illness that affects a substantial number of patients every year worldwide. The disease is characterised by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure. Although there is currently no cure, more than 85% of patients with Meniere's disease are helped by either changes in lifestyle and medical treatment, or minimally invasive surgical procedures such as intratympanic steroid therapy, intratympanic gentamicin therapy, and endolymphatic sac surgery. Vestibular neurectomy has a very high rate of vertigo control and is available for patients with good hearing who have failed all other treatments. Labyrinthectomy is undertaken as a last resort and is best reserved for patients with unilateral disease and deafness. PMID:18675691

Sajjadi, Hamed; Paparella, Michael M

2008-08-01

94

Diverticular Disease  

MedlinePLUS

... your large intestine. It is caused by small pouches (called diverticula) that can form anywhere in your ... disease are: Diverticulosis. People who have diverticulosis have pouches in the large intestine. Most people who have ...

95

Nail Diseases  

MedlinePLUS

... growth rate can be signs of lung, heart, kidney, and liver diseases, as well as diabetes and anemia. White spots and vertical ridges are harmless. Nail problems that sometimes require treatment include Bacterial and fungal infections Ingrown nails Tumors ...

96

Chagas disease  

MedlinePLUS

... help control the spread of the disease. Blood banks in Central and South America screen donors for ... discarded if the donor tests positive. Most blood banks in the United States began screening for Chagas ...

97

Fungal Diseases  

MedlinePLUS

... Chest & Lungs Chronic Conditions Developmental Disabilities Ear, Nose & Throat Emotional Problems Fever Genitals & Urinary Tract Head, Neck & Nervous System Obesity Skin Treatments View all Injuries & Emergencies Sports Injuries Vaccine Preventable Diseases Diphtheria Haemophilus ...

98

Graves' Disease  

MedlinePLUS

... Graves' disease can cause the following symptoms: Nervousness Insomnia Emotional swings Sweating Hand tremor Palpitations Unexplained weight ... medication such as propanolol (Inderal). For anxiety and insomnia, your doctor may prescribe diazepam (Valium), lorazepam (Ativan) ...

99

Alpers' Disease  

MedlinePLUS

... disease, failure to thrive, infection-associated encephalopathy, spasticity, myoclonus (involuntary jerking of a muscle or group of ... be difficult to control and unrelenting seizures can cause developmental regression as well. "Alpers-like" disorders without ...

100

Lung Disease  

MedlinePLUS

... Infections, such as influenza and pneumonia Lung cancer Sarcoidosis (sar-KOY-doh-sis) and pulmonary fibrosis Lung ... and can reduce oxygen flow into the blood. Sarcoidosis and pulmonary fibrosis. These inflammatory diseases cause stiffening ...

101

Alzheimer disease  

MedlinePLUS

Senile dementia - Alzheimer type (SDAT); SDAT ... The exact cause of Alzheimer disease (AD) is not known. Research shows that certain changes in the brain lead to AD developing. You are more likely ...

102

Lyme disease  

MedlinePLUS

Lyme disease is caused by bacteria called Borrelia burgdorferi ( B. burgdorferi) . Blacklegged ticks and other species of ticks can carry these bacteria. The ticks pick up the bacteria when they bite mice ...

103

Gaucher disease  

MedlinePLUS

... harmful substances to build up in the liver, spleen, bones, and bone marrow. The substances prevent cells ... common. It involves bone disease, anemia, an enlarged spleen and thrombocytopenia. Type I affects both children and ...

104

Méničre's Disease  

MedlinePLUS

... membranous labyrinth) filled with endolymph. Credit: NIH Medical Arts The symptoms of Méničre’s disease are caused by ... dizziness. Location of endolymphatic sac Credit: NIH Medical Arts Surgery. Surgery may be recommended when all other ...

105

Graves disease  

MedlinePLUS

... levels of TSH, T3, and free T4 Radioactive iodine uptake and scan This disease may also affect ... or more of the following: Antithyroid medications Radioactive iodine Surgery If you have had radioactive iodine treatment ...

106

Gaucher Disease  

MedlinePLUS

... problems and blood disorders. Is there any treatment? Enzyme replacement therapy is available for most people with types 1 ... and 3 Gaucher disease. What is the prognosis? Enzyme replacement therapy is very beneficial for type 1 and most ...

107

Fabry's Disease  

MedlinePLUS

... fever, and gastrointestinal difficulties. Is there any treatment? Enzyme replacement therapy has been approved by the U.S. Food and Drug Administration for the treatment of Fabry disease. Enzyme replacement therapy can reduce lipid storage, ease pain, and improve ...

108

Lung disease  

MedlinePLUS

... the lungs to take in oxygen and release carbon dioxide. People with this type of lung disorder often ... the lungs to take up oxygen and release carbon dioxide. These diseases may also affect heart function. An ...

109

Disease Resources  

Cancer.gov

Key Programs Disease Resources The ASCUS/LSIL Triage Study for Cervical Cancer (ALTS) Human Papillomavirus Cervical Cancer Screening NCI Bethesda System 2001 The Bethesda System Web Atlas National Cervical Cancer Coalition American Social

110

Crohn disease  

PubMed Central

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract.1 Prevalence in western populations is 100–150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority of affected individuals progress to relapsing and chronic disease. Medical treatments rely significantly on empirical corticosteroid therapy and immunosuppression, and intestinal resectional surgery is frequently required. Thus, 80% of patients with CD come to surgery for refractory disease or complications. It is hoped that an improved understanding of pathogenic mechanisms, for example by studying the genetic basis of CD and other forms of inflammatory bowel diseases (IBD), will lead to improved therapies and possibly preventative strategies in individuals identified as being at risk. PMID:20729636

Stappenbeck, Thaddeus S.; Rioux, John D.; Mizoguchi, Atsushi; Saitoh, Tatsuya; Huett, Alan; Darfeuille-Michaud, Arlette; Wileman, Tom; Mizushima, Noboru; Carding, Simon; Akira, Shizuo; Parkes, Miles; Xavier, Ramnik J.

2011-01-01

111

Parkinson disease  

MedlinePLUS

... with Parkinson disease: Stay healthy by eating nutritious foods and not smoking. Make changes in what you ... Jankovic J. Movement disorders. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in ...

112

Crohn's Disease  

MedlinePLUS

... KB) Spanish Version Additional Links Colonoscopy Microscopic Colitis Ulcerative Colitis Upper GI Endoscopy Upper GI Series Contact Us ... the GI tract, called inflammatory bowel disease (IBD). Ulcerative colitis and microscopic colitis are the other common IBDs. ...

113

Parkinson's Disease  

MedlinePLUS

... worse, people with the disease may have trouble walking, talking, or doing simple tasks. They may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking. There ...

114

Parkinson's Disease  

MedlinePLUS

... severe, people with the disorder may have difficulty walking, talking, or completing other simple tasks. They also experience non-motor, or movement, symptoms including mental and behavioral changes, sleep problems, depression, memory difficulties, and fatigue. Parkinson's disease ...

115

Celiac Disease  

MedlinePLUS

... Phone: 703–622–3331 Email: info@americanceliac.org Internet: www.americanceliac.org American Dietetic Association 120 South ... Chicago, IL 60606–6995 Email: hotline@eatright.org Internet: www.eatright.org Celiac Disease Foundation 13251 Ventura ...

116

Lyme Disease  

MedlinePLUS

... occur in the spring and summer months. The tick bite is rarely painful, so after any exposure to ... tick still attached to the skin. Not every tick bite will result in Lyme disease, but it is ...

117

Chronic Diseases  

Microsoft Academic Search

Although diabetes mellitus, cardiovascular disease, and human immunodeficiency virus infection are three separate entities,\\u000a each has causal and non-causal risk factors that are common in the stage 5 chronic kidney disease population. The medical\\u000a nutrition therapies are similar, which emphasize adequate protein and energy intakes, fluid control, and possibly carbohydrate\\u000a and fat modifications. Each patient requires an individualized evaluation, taking

Sharon R. Schatz

118

Meničre's disease.  

PubMed

Meničre's disease is the most common cause of true vertigo and it affects about 2.4 million Americans. Episodic tinnitus, hearing loss, vertigo, and aural fullness are the classic findings. The symptom which is most debilitating and which causes most people to seek treatment is vertigo. Most patients respond extremely well to medical management and only rarely is surgery necessary. This paper discusses the symptoms, diagnosis, and clinical course of Meničre's disease. Medical and surgical therapeutic options are discussed. PMID:7844461

Mixon, T; Letta, C; Amedee, R

1994-12-01

119

Rice Diseases.  

E-print Network

constraints (particularly fuel prices) have all but eliminated this practice that served to reduce initial inoculum of many rice diseases by deep burial of sclerotia and infected crop residue. *Extension plant pathologist , The Texas A&M University System... slower to emerge may suffer reductions in stand and potential yield not encountered with varieties that emerge rapidly. Chemical seed treatment is a very cost effective way of minimizing potential damage from seedling disease. See the seed treatment...

Jones, Roger K.

1987-01-01

120

Lentil Diseases  

Microsoft Academic Search

Fungal diseases of lentils are the most important biological constraint to productivity. Ascochyta lentis (ascochyta blight) and Fusarium oxysporum f. sp. lentis (fusarium wilt) are the major fungal pathogens that can cause severe losses in most lentil growing regions of the world.\\u000a Fungal diseases such as botrytis grey mould (Botrytis fabae and B. cinerea), rust (Uromyces viciae-fabae), stemphylium blight (Stemphylium

Paul Taylor; Kurt Lindbeck; Weidong Chen; Rebecca Ford

121

Parkinson's Disease  

Microsoft Academic Search

In this chapter the topic of inflammation in Parkinson’s disease (PD) and in models of human disease will be reviewed. To\\u000a set the stage, the biological, clinical and pathological hallmarks of PD and related degenerative conditions will be presented.\\u000a A more comprehensive review of PD can be found in the following two references (Fahn and Przedborski, 2005; Dauer and Przedborski,

Serge Przedborski

122

Méničre Disease  

Microsoft Academic Search

A computerized PubMed search of MEDLINE 1966-May 2005 was performed. The terms “Meniere disease” and “gentamicin” were exploded,\\u000a and the resulting articles were combined. The terms “intratympanic” and “transtympanic” were entered as text words as the\\u000a search term “intratympanic OR transtympanic,” and the results were combined with the Méničre disease\\/gentamicin articles.\\u000a The resulting 136 articles were limited to the English

Iee-Ching Wu Anderson; John P. Carey; Walter Kutz; William H. Slattery

123

Caroli's disease.  

PubMed

Caroli's disease is characterized by multifocal segmental dilatation of the intrahepatic bile ducts. It is a rare congenital condition, which appears to be autosomal recessively inherited in most cases. There are two forms of disease, one associated with congenital hepatic fibrosis and a simple form occurring alone. Recent reports suggest that the simple form may be as common as that with congenital hepatic fibrosis. Other conditions, including choledochal cyst and renal cystic disease, are frequently associated. The major clinical feature is recurrent cholangitis, which may be complicated by intrahepatic calculi and hepatic abscess formation. There is good evidence that malignancy complicates Caroli's disease in approximately 7% of cases. The diagnosis rests on demonstrating that the cystic liver lesions are in continuity with the biliary tree. Modern imaging techniques allow the diagnosis to be made more easily and without invasive imaging of the biliary tree. The treatment depends on the clinical features and the location of the biliary abnormality. When the disease is localized to one hepatic lobe, hepatectomy relieves symptoms and appears to remove the risk of malignancy. In diffuse Caroli's disease, treatment options include conservative or endoscopic therapy, internal biliary bypass procedures and liver transplantation in carefully selected cases. PMID:9581983

Taylor, A C; Palmer, K R

1998-02-01

124

Infection and Cardiovascular Disease  

ClinicalTrials.gov

Cardiovascular Diseases; Coronary Disease; Cerebrovascular Accident; Heart Diseases; Myocardial Infarction; Infection; Chlamydia Infections; Cytomegalovirus Infections; Helicobacter Infections; Atherosclerosis

2005-06-23

125

[Allergic diseases as environmental diseases].  

PubMed

Respiratory allergic diseases belong to atopic diseases. Their prevalence has steadily increased over the past decades. Recently, a plateau effect seems to occur. This increased prevalence should be related to environmental changes. However, "classical" aerocontaminants, such as aero-allergens and air pollutants cannot account for such a drastic increase in prevalence. Change in diet can account for biological changes but the relation to allergic diseases seems questionable. Use of contraceptive pills and caesarean section had been put forward as hypotheses but their implication seems unlikely. Among the classical risk factors, 2 only should remain in the primary prevention of atopic diseases, namely, prolonged breast feeding and avoiding passive smoking. The major input of epidemiological research over the past decades lies in the "hygienic hypothesis" and the protective effect of early exposure to farm animals and raw cow milk. Progress to come in this field should lie in a better knowledge of in utero exposure on the foetal immune system. PMID:17717941

Charpin, Denis

2007-06-30

126

Neurodegenerative diseases ranging from Alzheimer disease and polyglutamine diseases to transmissible spongiform enceph-  

E-print Network

, we focus on three neuro- degenerative diseases, Alzheimer disease, Huntington disease and prion with Neurodegenerative Diseases The protein deposits found in Alzheimer disease, Huntington disease and prion diseaseNeurodegenerative diseases ranging from Alzheimer disease and polyglutamine diseases

Lindquist, Susan

127

Meničre's disease  

PubMed Central

Introduction Meničre's disease causes recurrent vertigo, hearing loss, tinnitus, and fullness or pressure in the ear, which mainly affects adults aged 40-60 years. Meničre's disease is at first progressive but fluctuating, and episodes can occur in clusters. Vertigo usually resolves but hearing deteriorates, and symptoms other than hearing loss and tinnitus usually improve regardless of treatment. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for acute attacks of Meničre's disease; and of interventions to prevent attacks and delay disease progression of Meničre's disease? We searched: Medline, Embase, The Cochrane Library and other important databases up to January 2006 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 17 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: anticholinergics, benzodiazepines, betahistine, cinnarizine, dietary modification, diuretics, phenothiazines, psychological support, trimetazidine, vestibular rehabilitation. PMID:19454061

2007-01-01

128

Wilson's disease.  

PubMed

(Full text is available at http://www.manu.edu.mk/prilozi). Wilson's disease (WD) is a disorder of copper transport resulting from the defective function of a copper transporting P-type ATPase, ATP7B. The WD incidence is approximately 1/50-10,000 live births worldwide. Clinical manifestations of WD may be of any kind, but usually the symptoms of presentation are hepatic or neuropsychiatric, with a vast range of disturbances for both groups of symptoms. In children, however, clinical symptoms may be absent, making the diagnosis of the disease more difficult than in adults. Hepatic manifestations may range from asymptomatic minor biochemical disturbances, to acute, but mostly chronic, hepatitis, cirrhosis or severe fulminant hepatic failure. The spectrum of neurological manifestations is wide, including tremor, hypersalivation, Dysarthria, coordination defects, dystonia, ataxia. The spectrum of psychiatric manifestations is considerable and may include different disturbances such as altered working performance, anxiety, depression and antisocial behaviour. Kayser-Fleischer rings (KF) are present in 95% of patients with neurological symptoms and somewhat over half of those without neurological symptoms. In children presenting with liver disease, KF rings are usually absent. To obtain a more reliable diagnosis of WD, the Leipzig scoring system was proposed by an international consensus of experts. Wilson's disease copper overload is treated with chelating agents such as penicillamine, trientine and tetrathiomolybdate. Zinc is used mostly for mantainance therapy or the treatment of asymptomatic WD patients. Key words: Wilson diseases, copper, cirrhosis, children. PMID:24798599

Loudianos, G; Lepori, M B; Mameli, E; Dessě, V; Zappu, A

2014-01-01

129

Fabry's disease.  

PubMed

Fabry's disease is an X-linked lysosomal storage disorder caused by abnormalities in the GLA gene, which leads to a deficiency in ?-galactosidase A. The abnormal accumulation of glycosphingolipids, primarily globotriaosylceramide, manifests as serious and progressive impairment of renal and cardiac functions. In addition, patients experience pain, gastrointestinal disturbance, transient ischemic attacks and strokes. Disease presentation in female heterozygotes may be as severe as in males although women may also remain asymptomatic. This review covers all basic aspects of the disease such as epidemiology, pathophysiology, clinical presentation by systems, diagnosis, management, prevention, and repercussions on quality of life. With the development of enzyme replacement therapy in the past few years, early initiation of treatment was found to be key for reduction of disease burden in major affected organs with improvement in neuropathic pain, decreased cardiac mass and stabilization of renal function, gastrointestinal symptoms, and hearing. This review aims to raise the awareness of the signs and symptoms of Fabry's disease as well as to provide guidelines for the diagnosis and treatment. PMID:25106696

El-Abassi, Rima; Singhal, Divya; England, John D

2014-09-15

130

Crohn's Disease  

NSDL National Science Digital Library

This patient education program explains Crohn's Disease, one of the most common inflammatory bowel diseases, including the symptoms, diagnosis, and treatment options. It also reviews the anatomy of the gastrointestinal system, causes of the disease, dietary triggers, and pregnancy in the Crohn's patient. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. NOTE: This tutorial requires a special Flash plug-in, version 4 or above. If you do not have Flash, you will be prompted to obtain a free download of the software before you start the tutorial. You will also need an Acrobat Reader, available as a free download, in order to view the Reference Summary.

Patient Education Institute

131

Celiac disease.  

PubMed

On the basis of strong evidence, gastrointestinal symptoms and failure to thrive are classic presentations of celiac disease, but atypical, nongastrointestinal symptoms are also extremely common, particularly in the older child and adolescent. (3)(4)(8). On the basis of some research evidence and consensus, guidelines recommend celiac testing in symptomatic children with typical and atypical symptoms and consideration of testing in those with associated conditions and first-degree relatives of those with celiac disease. (3)(9). On the basis of strong research evidence, measurement of tTG IgA and total serum IgA level has been reported to be the most cost-effective and accurate means of serologic testing for celiac disease and is the test of choice unless the child is younger than 2 years or IgA deficient. (9). On the basis of strong research evidence, children with elevated titers of celiac antibodies or strong clinical suspicion for celiac disease should be referred to a gastroenterologist for upper endoscopy and biopsy. Until this procedure is performed, the child should continue on a diet with ingestion of gluten. (3)(9). On the basis of strong research evidence, all those with a confirmed diagnosis of celiac disease should follow a strict gluten-free diet for life, with avoidance of all foods that contain wheat, barley, and rye ingredients. (3)(4). Referral to a health care professional with specialized knowledge of celiac disease and the gluten-free diet is critical because of the numerous ways, often hidden, in which gluten may be present in the diet and environment. PMID:25274968

Ediger, Tracy R; Hill, Ivor D

2014-10-01

132

Pilonidal Disease  

PubMed Central

Pilonidal disease presents many therapeutic challenges to surgeons throughout the world. Its varied clinical presentations necessitate a wide range of treatments, thus underscoring the need to tailor the treatment to the patient and the severity of disease. Recent studies confirm the efficacy of smaller, more conservative operations for appropriate indications. When flap closures are performed, every attempt should be directed to placing sutures off (lateral) to the midline gluteal cleft. Meticulous attention to the details of immediate and long-term postoperative care is paramount. PMID:22379405

Khanna, Amit; Rombeau, John L.

2011-01-01

133

Lung Diseases  

MedlinePLUS

When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to ... you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in ...

134

Graves' Disease  

MedlinePLUS

... disease that affects the adrenal glands, which make hormones that help your body respond to stress and regulate your blood pressure and water and ... find the gene or genes involved. Gender. Sex hormones might play a role, ... than men. Stress. Severe emotional stress or trauma might trigger the ...

135

Peyronie's Disease  

MedlinePLUS

... Behcet’s syndrome––inflammation of the blood vessels Family History of Peyronie’s Disease Medical experts believe that Peyronie’s ... a physical exam imaging tests Medical and Family History Taking a medical and family history is one ...

136

SMUT DISEASES  

Technology Transfer Automated Retrieval System (TEKTRAN)

A COMPREHENSIVE REVIEW OF MOST ASPECTS OF COMMON BUNT AND DWARF BUNT DISEASES OF WHEAT IS PRESENTED. INCLUDED ARE SECTIONS ON HISTORY, DISTRIBUTION AND ECONOMIC IMPORTANCE, TAXONOMY, MORPHOLOGY, SPORE GERMINATION, CULTURE, AND PHYSIOLOGY. EXTENSIVE SECTIONS DEAL WITH RESEARCH METHODOLOGY AND DISEA...

137

Moyamoya disease.  

PubMed

A 4 years old boy presented with acute left hemiplegia. Preliminary neuroimaging suggested an arterial ischemic process. Clinical and laboratory evaluation excluded haematologic, metabolic and vasculitic causes. Cerebral angiography confirmed the diagnosis of Moyamoya disease. Treatment included physiotherapy and close follow-up for recurrence. PMID:21798142

Rafiq, Asim; Vaqar, Abeer; Javaid, Khalid Hussain; Parveen, Rashida; Sadaf, Rabia

2011-08-01

138

Smelling Diseases  

NSDL National Science Digital Library

We all use our noses to make quick judgments from time to time -- whether it's checking to see if the milk's still good, or if a shirt needs to go in the wash. Now, doctors are developing a kind of sniff test to screen for diseases. Find out more in this Science Update.

Science Update

2004-06-14

139

Prion Diseases  

MedlinePLUS

... nasal test for the human prion disease CJD Javascript Error Your browser JavaScript is turned off causing certain features of the ... incorrectly. Please visit your browser settings and turn JavaScript on. Read more information on enabling JavaScript. Prion ...

140

Infectious Diseases  

NSDL National Science Digital Library

With the threat of a warmer, wetter world and a larger global population, scientists are researching how climate change may impact the spread of infectious diseases,ťsuch as cholera and dengue fever, and how outbreaks may be prevented.ť "Changing Planet" is produced in partnership with the National Science Foundation.

NBC Learn

2010-10-07

141

Avocado diseases  

Microsoft Academic Search

Several fungi can cause diseases of avocado (Persea americana (Mill.)) of which Phytophthora cinnamomi Rands is the most serious. Phytophthora root rot causes extensive losses of avocado trees in nearly every country where avocados are grown. The fungus can be isolated from soil and roots by using selective agar media containing antibiotic chemicals and by using various types of baits

G. A. Zentmyer

1984-01-01

142

Dent's disease  

Microsoft Academic Search

Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. These features are generally found in males only, and may be present in early childhood, whereas female carriers may show a milder phenotype. Prevalence is unknown; the disorder has been reported in around 250 families to

Olivier Devuyst; Rajesh V. Thakker

2010-01-01

143

Coronary heart disease  

MedlinePLUS

Heart disease, Coronary heart disease, Coronary artery disease; Arteriosclerotic heart disease; CHD; CAD ... Coronary heart disease (CHD) is the leading cause of death in the United States for men and women. Coronary ...

144

Diabetic Heart Disease  

MedlinePLUS

... from the NHLBI on Twitter. What Is Diabetic Heart Disease? The term "diabetic heart disease" (DHD) refers ... Kidney Diseases' Introduction to Diabetes Web page. What Heart Diseases Are Involved in Diabetic Heart Disease? DHD ...

145

Acid Lipase Disease  

MedlinePLUS

NINDS Acid Lipase Disease Information Page Synonym(s): Cholesterol Ester Storage Disease, Wolman’s Disease Table of Contents (click to jump ... research is being done? Clinical Trials What is Acid Lipase Disease ? Acid lipase disease occurs when the ...

146

American Behcet's Disease Association  

MedlinePLUS

... through a grant from Celgene Corporation. Rare Disease Day Rare Disease Day Behcet's Disease Awareness Share your story and educate ... Behcet's Disease Month May 20th is Behcet's Awareness Day American Behcet's Disease Association Contact Us | Website Policy | ...

147

Coronary Heart Disease  

MedlinePLUS

... from the NHLBI on Twitter. What Is Coronary Heart Disease? Espańol Coronary heart disease (CHD) is a disease ... Coronary Heart Disease, visit www.clinicaltrials.gov . Coronary Heart Disease in the News November 18, 2014 NHLBI Media ...

148

HIV and Rheumatic Disease  

MedlinePLUS

... Patient Resources > Diseases & Conditions Back to Diseases & Conditions HIV and Rheumatic Disease PRINT Download PDF HIV infection ... treatment and HIV infection all overlap. What are HIV-associated rheumatic diseases? Some diseases of the joints ...

149

Fabry disease  

PubMed Central

Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal ?-galactosidase A activity. FD is pan-ethnic and the reported annual incidence of 1 in 100,000 may underestimate the true prevalence of the disease. Classically affected hemizygous males, with no residual ?-galactosidase A activity may display all the characteristic neurological (pain), cutaneous (angiokeratoma), renal (proteinuria, kidney failure), cardiovascular (cardiomyopathy, arrhythmia), cochleo-vestibular and cerebrovascular (transient ischemic attacks, strokes) signs of the disease while heterozygous females have symptoms ranging from very mild to severe. Deficient activity of lysosomal ?-galactosidase A results in progressive accumulation of globotriaosylceramide within lysosomes, believed to trigger a cascade of cellular events. Demonstration of marked ?-galactosidase A deficiency is the definitive method for the diagnosis of hemizygous males. Enzyme analysis may occasionnally help to detect heterozygotes but is often inconclusive due to random X-chromosomal inactivation so that molecular testing (genotyping) of females is mandatory. In childhood, other possible causes of pain such as rheumatoid arthritis and 'growing pains' must be ruled out. In adulthood, multiple sclerosis is sometimes considered. Prenatal diagnosis, available by determination of enzyme activity or DNA testing in chorionic villi or cultured amniotic cells is, for ethical reasons, only considered in male fetuses. Pre-implantation diagnosis is possible. The existence of atypical variants and the availability of a specific therapy singularly complicate genetic counseling. A disease-specific therapeutic option - enzyme replacement therapy using recombinant human ?-galactosidase A - has been recently introduced and its long term outcome is currently still being investigated. Conventional management consists of pain relief with analgesic drugs, nephroprotection (angiotensin converting enzyme inhibitors and angiotensin receptors blockers) and antiarrhythmic agents, whereas dialysis or renal transplantation are available for patients experiencing end-stage renal failure. With age, progressive damage to vital organ systems develops and at some point, organs may start to fail in functioning. End-stage renal disease and life-threatening cardiovascular or cerebrovascular complications limit life-expectancy of untreated males and females with reductions of 20 and 10 years, respectively, as compared to the general population. While there is increasing evidence that long-term enzyme therapy can halt disease progression, the importance of adjunctive therapies should be emphasized and the possibility of developing an oral therapy drives research forward into active site specific chaperones. PMID:21092187

2010-01-01

150

Morgellons disease?  

PubMed

Morgellons disease, a pattern of dermatologic symptoms very similar, if not identical, to those of delusions of parasitosis, was first described many centuries ago, but has recently been given much attention on the internet and in the mass media. The present authors present a history of Morgellons disease, in addition to which they discuss the potential benefit of using this diagnostic term as a means of building trust and rapport with patients to maximize treatment benefit. The present authors also suggest "meeting the patient halfway" and creating a therapeutic alliance when providing dermatologic treatment by taking their cutaneous symptoms seriously enough to provide both topical ointments as well as antipsychotic medications, which can be therapeutic in these patients. PMID:18318880

Accordino, Robert E; Engler, Danielle; Ginsburg, Iona H; Koo, John

2008-01-01

151

Thyroid disease  

SciTech Connect

Presenting a multidisciplinary approach to the diagnosis and treatment of thyroid disease, this volume provides a comprehensive picture of current thyroid medicine and surgery. The book integrates the perspectives of the many disciplines that deal with the clinical manifestations of thyroid disorders. Adding to the clinical usefulness of the book is the state-of-the-art coverage of many recent developments in thyroidology, including the use of highly sensitive two-site TSH immunoradionetric measurements to diagnose thyroid activity; thyroglobulin assays in thyroid cancer and other diseases; new diagnostic applications of MRI and CT; treatment with radionuclides and chemotherapy; new developments in thyroid immunology, pathology, and management of hyperthyroidism; suppressive treatment with thyroid hormone; and management of Graves' ophthalmopathy. The book also covers all aspects of thyroid surgery, including surgical treatment of hyperthyroidism; papillary, follicular, and other carcinomas; thyroidectomy; and prevention and management of complications.

Falk, S.

1990-01-01

152

Kidney Disease  

Microsoft Academic Search

Crohn’s disease (CD) potentially affects many organs, including, albeit rarely, the kidney. The most frequent renal manifestations\\u000a are calcium oxalate stones and their complications; secondary amyloidosis; acute tubular necrosis related to volume depletion\\u000a caused by diarrheal fluid losses or inadequate fluid intake, or both. Tubulo-interstitial nephritis is another common finding\\u000a and, among patients with CD, the most common cause is

Margherita Rosa; Salvatore Giulio

153

Wilson's disease  

Microsoft Academic Search

Wilson's disease is an autosomal recessive disorder of hepatic copper disposition caused by mutations in the gene ATP7B, located on chromosome 13. This gene encodes a P-type adenosine triphosphatase (ATPase), known as the Wilson ATPase, which functions within hepatocytes to move copper across intracellular membranes. The copper-transporting action directly supports production of the ferroxidase caeruloplasmin, in which copper is incorporated,

Eve A. Roberts

2011-01-01

154

[Wilsons disease].  

PubMed

Wilsons disease is an autosomal recessive genetic disorder in which copper accumulates in tissues, especially in the liver and the brain. The genetic defect affects the P type ATPase gene (ATP7B). More than 500 mutations causing Wilsons disease have been described. The most common mutation in Central Europe concerns H1069Q. The symptoms of Wilsons disease include hepatic or neurological conditions. The hepatic condition is manifested as steatosis, acute or chronic hepatitis or cirrhosis. The neurological conditions are most often manifested after the age of 20 as motor disorders (tremor, speech and writing disorders), which may result in severe extrapyramidal syndrome with rigidity, dysarthria and muscle contractions. The dia-gnosis is based on clinical and laboratory assessments (neurological signs, liver lesions, low ceruloplasmin, increased free serum copper, high Cu volumes in urine, KayserFleischer ring). The dia-gnosis is confirmed by a high Cu level in liver tissue or genetic proof. Untreated Wilsons disease causes death of the patient. If treated properly the survival rate approximates to the survival rate of the common population. The treatment concerns either removal of copper from the body using chelating agents excreted into the urine (Penicillamine, Trientine) or limitation of copper absorption from the intestine and reducing the toxicity of copper (zinc, ammonium tetrathiomolybdate). In the Czech Republic, Penicillamine or zinc is used. A liver transplant is indicated in patients with fulminant hepatic failure or decompensated liver cirrhosis. In the family all siblings of the affected individual need to be screened in order to treat any asymptomatic subjects. PMID:23909262

Mare?ek, Z; Br?ha, R

2013-07-01

155

Desmoid Disease  

Microsoft Academic Search

\\u000a Desmoid disease is an overgrowth of fibrous tissue that presents in patients with Familial Adenomatous Polyposis (FAP) as\\u000a a spectrum of lesions from flat, twodimensional sheets to large, rapidly growing, three-dimensional tumors. FAPrelated desmoid\\u000a tumors can be confused with sporadic desmoids that occur in the general population with an incidence of two to three per million\\u000a [1]. These sporadic desmoids

James M. Church

156

Kawasaki Disease  

Microsoft Academic Search

\\u000a Kawasaki disease (KD) is more common in Japanese population and those of Japanese descent. Incidence is higher in males than\\u000a females. Etiology of KD continues to be unclear, there is evidence supporting both genetic and environmental factors. Diagnosis\\u000a of KD is made when there is fever of at least 5 days duration, plus bilateral, nonpurulent conjunctivitis, polymorphous skin\\u000a rash, mucous

Rami Kharouf; Daniel E. Felten

157

Stargardt Disease  

Microsoft Academic Search

When the adenosine triphosphate (ATP)-binding cassette (ABC) transporter gene, ABCA4 (originally named ABCR), was cloned and characterized in 1997 as the causal gene for autosomal recessive Stargardt disease (arSTGD or STGD1) (1) it seemed as if just another missing link was added to the extensive table of genetic determinants of rare monogenic retinal\\u000a dystrophies. Now, 9 yr later, the ABCA4

Rando Allikmets

158

Sorghum Diseases.  

E-print Network

made for maximum use of available land. practices. 20 A 1 SELECTED REFERENCES DICKSON, JAMES G., 1956, Diseases of Field Crops, McGraw-Hill Book Company, Znc., New York, p. 517. EDMUNDS, L. K., 1963, Combined relation of plant maturity... of commercially grown grain sorghum and forage sorghum hybrids and varieties to downy mildew (Sclerospora sorghi). Texas Agricultural Experiment Station Progress Report-PR2629. FREDERIKSEN, R. A., D. T. ROSENOW, L. REYES, and L. K. EDMUNDS, 1969, A new race...

Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

1969-01-01

159

[Liver diseases].  

PubMed

In Digestive Disease Week 2008, interesting advances in the treatment of hepatitis C were presented, especially related to the promising increase in the therapeutic efficacy of the combination of conventional treatment with the protease inhibitor, telaprevir. Also revealed was the influence of viral replication of hepatitis B virus in the development of complications, including hepatocarcinoma. In this sense, drugs such as entecavir and tenofovir seem to provide sustained inhibition of viral replication without the development of resistance. Among the complications of cirrhosis, the growing prognostic implications of bacterial infections, associated with an increased risk of death, have been demonstrated. Likewise, diverse studies have provided greater understanding of the role of elastography in the evaluation of liver fibrosis, including the role of this technique in the evaluation of treatment response and in liver transplantation. The importance of fatty acid liver disease was clearly shown in several studies confirming the influence of diabetes in the presence of inflammation and fibrosis and the increase in the indication of liver transplantation for this disease, which may recur in the graft, especially in patients with a high body mass index. A meta-analysis of hepatocarcinoma and a decision model were unable to detect differences in survival in small tumors treated with radiofrequency or surgery. PMID:19434874

Calleja, José Luis; Albillos, Agustín; Bańares, Rafael

2008-10-01

160

Celiac Disease National Digestive Diseases Information Clearinghouse  

E-print Network

Celiac Disease National Digestive Diseases Information Clearinghouse National Institute. This list is not complete, so people with celiac disease should discuss gluten-free food choices with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food

Rau, Don C.

161

Plant Disease Lesson: Rhizoctonia Diseases of Turfgrass  

NSDL National Science Digital Library

This plant disease lesson on Rhizoctonia diseases of turfgrass (caused by the fungi Rhizoctonia species) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

Lane P. Tredway (University of Georgia, Athens; )

2001-11-09

162

Plant Disease Lesson: Lesion nematode disease  

NSDL National Science Digital Library

This plant disease lesson on Lesion nematode disease (caused by Pratylenchus) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

Eric L. Davis (North Carolina State University; )

2000-10-30

163

Plant Disease Lesson: Soybean cyst nematode disease  

NSDL National Science Digital Library

This plant disease lesson on Soybean cyst nematode disease (caused by Heterodera glycines) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

Eric L. Davis (North Carolina State University; )

2000-07-25

164

Plant Disease Lesson: Dutch elm disease  

NSDL National Science Digital Library

This plant disease lesson on Dutch elm disease (caused by the fungus Ophiostoma ulmi) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

Cleora J. D'Arcy (University of Illinois; )

2000-07-21

165

Parkinson's Disease  

NSDL National Science Digital Library

This patient education program discusses the symptoms, and treatment options for Parkinson's Disease, including their benefits and side effects. It also reviews the anatomy of the central nervous system. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. NOTE: This tutorial requires a special Flash plug-in, version 4 or above. If you do not have Flash, you will be prompted to obtain a free download of the software before you start the tutorial. You will also need an Acrobat Reader, available as a free download, in order to view the Reference Summary.

Patient Education Institute

166

Infectious disease.  

PubMed

Athletes are susceptible to the same infections as the general population. However, special considerations often need to be taken into account when dealing with an athlete who has contracted an infectious disease. Health care providers need to consider how even common illnesses can affect an athlete's performance, the communicability of the illness to team members, and precautions/contraindications related to athletic participation. Recent advances in the prevention, diagnosis, and/or management of frequently encountered illnesses, as well as certain conditions that warrant special attention in the athletic setting, are discussed in detail. PMID:21658549

Jaworski, Carrie A; Donohue, Brian; Kluetz, Joshua

2011-07-01

167

Celiac Disease  

PubMed Central

Purpose of review To summarize recent advances in celiac disease (CD) published between August 2008 and July 2009. Recent findings CD affects ~1% of most populations but remains largely unrecognized. In the last year, work has shown that the prevalence of CD has increased dramatically, not simply due to increased detection. Also, undiagnosed CD may be associated with increased mortality. Significant progress has been made in understanding how gliadin peptides can cross the intestinal border and access the immune system. New genetic loci and candidate genes that may contribute to the risk of CD and its overlap with type 1 diabetes mellitus have been identified. New deamidated gliadin peptides antibodies have better diagnostic accuracy over native gliadin-based tests. The inclusion of duodenal bulb biopsy specimens may increase the rate of CD detection. The spectrum of CD likely includes a minority of patients with mild enteropathy. A practical 7-item instrument may facilitate standardized evaluation of gluten-free diet adherence. Finally, refractory CD, whilst rare, is associated with a poor prognosis. Summary Celiac disease is a global health problem that requires a multidisciplinary and increasingly cooperative multinational research effort. PMID:20040864

Rubio-Tapia, Alberto; Murray, Joseph A

2010-01-01

168

[Morton's disease].  

PubMed

Morton's disease refers to neuralgia at the web space of the toes with a pseudo-neuroma. It commonly occurs in the third web space of the foot in middle-aged and older women. The pseudo-neuroma is thought to be a secondary change after entrapment or repeated microtrauma. Patients complain of forefoot pain while walking. Typically, symptoms are caused by tight high-heeled shoes. The physical examination includes palpation of the web spaces and Mulder's test. Weight bearing foot radiographs are used to evaluate the deformity of the foot, especially at metatarsophalangeal (MTP) joints. MRI is useful for differential diagnosis of pseudo-neuroma, MTP joint arthritis, and interdigital bursitis. Conservative treatments are shoe modification, use of orthotic insoles, and injection of corticosteroids and local anesthesia. The injections are useful not only for the treatment but also for diagnosis of Morton's disease. If the local injection is not temporally effective, surgical treatment is not indicated. If the conservative treatment fails, surgical treatment is indicated. The most common surgery is excision of the pseudo-neuroma. The surgery is usually performed using a dorsal approach. PMID:25475032

Isomoto, Shinji; Tanaka, Yasuhito

2014-12-01

169

Adenotonsillar disease.  

PubMed

Adenotonsillar disease (adenoiditis and recurrent tonsillitis) is a prevalent otolaryngologic disorder aetiologically based on chronic inflammation triggered by a persistent bacterial infection. These bacteria, mostly Staphylococcus aureus, Haemophilus sp., and Streptococcus sp., persist predominantly intracellular and within mucosal biofilms. The recurrent or chronic inflammation of the adenoids and faucial tonsils leads to chronic activation of the cell-mediated and humoral immune response, resulting in hypertrophy of the lymphoid tonsillar tissue. This hypertrophic tissue is the cause for the prominent clinical symptoms: obstruction of the upper airways, snoring, and sleep apnea for adenoiditis or sore throat, dysphagia and halitosis for recurrent tonsillitis. Treatment strategies should target the persisting bacteria within their biofilm or intracellular shelter. Macrolide antibiotics like clarithromycin are able to modulate the immune system and to interfere in bacterial signaling within biofilms. Clindamycin, quinupristin-dalfopristin, and oritavancin are intracellular high active compounds. Surgical removal of the hypertrophic tissue by modern procedures like laser tonsil ablation, eliminates not only a mechanical obstacle of the airways, it removes also the basis for the aetiologic cause, the "biofilm carrier". This review summarizes the role of bacterial persistence in mucosal biofilms for the aetiology, diagnosis and treatment of adenotonsillar disease and relevant patents. PMID:22452646

Zautner, Andreas E

2012-05-01

170

Chagas' disease.  

PubMed Central

Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS. Images PMID:1423218

Tanowitz, H B; Kirchhoff, L V; Simon, D; Morris, S A; Weiss, L M; Wittner, M

1992-01-01

171

Kidney Disease Basics  

MedlinePLUS

... Disease Children and Kidney Disease Additional Kidney Information Kidney Disease Basics Your kidneys filter extra water and ... blood pressure are the most common causes of kidney disease. These conditions can slowly damage the kidneys ...

172

Depression and Heart Disease  

MedlinePLUS

... see the NIMH booklet on Depression . What is heart disease? Heart disease refers to a number of ... and save your life. How are depression and heart disease linked? People with heart disease are more ...

173

Motor Neuron Diseases  

MedlinePLUS

NINDS Motor Neuron Diseases Information Page Condensed from Motor Neuron Diseases Fact Sheet Table of Contents (click to jump to ... is being done? Clinical Trials Organizations What are Motor Neuron Diseases? The motor neuron diseases (MNDs) are a ...

174

Parkinson's Disease Dementia  

MedlinePLUS

Parkinson's Disease Dementia Tweet Parkinson's disease dementia is an impairment in thinking and reasoning that eventually affects many people with Parkinson's ... Symptoms Diagnosis Causes & risks Treatments About Parkinson's disease dementia The brain changes caused by Parkinson's disease begin ...

175

About Alzheimer's Disease: Symptoms  

MedlinePLUS

... more about other early signs of Alzheimer's » Mild Alzheimer's disease As the disease progresses, memory loss worsens, and ... disease is often diagnosed at this stage. Moderate Alzheimer's disease In this stage, damage occurs in areas of ...

176

Dejerine-Sottas Disease  

MedlinePLUS

... Progress Search form Search Charcot-Marie-Tooth Disease (CMT) Dejerine-Sottas disease What is Dejerine-Sottas disease? ... is a subtype of Charcot-Marie-Tooth disease (CMT), a genetic, neurological disorder that causes damage to ...

177

Testing for Kidney Disease  

MedlinePLUS

... and Kidney Disease Additional Kidney Information Testing for Kidney Disease Early kidney disease usually does not have signs ( ... how often you should be tested. Testing for Kidney Disease Overview Understanding GFR Understanding Urine Albumin Videos Testing ...

178

Machado-Joseph Disease  

MedlinePLUS

NINDS Machado-Joseph Disease Information Page Condensed from Machado-Joseph Disease Fact Sheet Table of Contents (click to jump ... is being done? Clinical Trials Organizations What is Machado-Joseph Disease? Machado-Joseph disease (MJD), which is ...

179

Poorly Responsive Celiac Disease  

MedlinePLUS

... Sources of Gluten . Microscopic Colitis, Crohn’s Disease and Ulcerative Colitis People with celiac disease have an increased incidence ... colitis and inflammatory bowel disease (Crohn’s disease and ulcerative colitis). Microscopic colitis is an inflammation of the colon, ...

180

Learning about Crohn's Disease  

MedlinePLUS

... Dietary Treatment of Crohn's Disease Immune Regulation in Ulcerative Colitis or Crohn's Disease Current NHGRI Clinical Studies Search ... to finding the cure for Crohn's disease and ulcerative colitis. Crohn's Disease and Ulcerative Colitis: A Parent's Guide [ ...

181

Mitochondrial disease  

Microsoft Academic Search

Opinion statement  \\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a •Mitochondrial diseases are disorders of energy metabolism that include defects of pyruvate metabolism, Krebs cycle, respiratory\\u000a chain (RC), and fatty acid oxidation (FAO).\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a •Treatment of pyruvate metabolism, Krebs cycle, and RC disorders is, in general, disappointing. Therapeutic approaches consist\\u000a of electron acceptors, enzyme activators, vitamins, coenzymes, free-radical scavengers, dietary measures, and supportive therapy.\\u000a These treatment assumptions

Roser Pons; Darryl C. De Vivo

2001-01-01

182

Alzheimer disease  

PubMed Central

Alzheimer disease (AD) has traditionally been thought to involve the misfolding and aggregation of two different factors that contribute in parallel to pathogenesis: amyloid-? (A?) peptides, which represent proteolytic fragments of the transmembrane amyloid precursor protein, and tau, which normally functions as a neuronally enriched, microtubule-associated protein that predominantly accumulates in axons. Recent evidence has challenged this model, however, by revealing numerous functional interactions between A? and tau in the context of pathogenic mechanisms for AD. Moreover, the propagation of toxic, misfolded A? and tau bears a striking resemblance to the propagation of toxic, misfolded forms of the canonical prion protein, PrP, and misfolded A? has been shown to induce tau misfolding in vitro through direct, intermolecular interaction. In this review we discuss evidence for the prion-like properties of both A? and tau individually, as well as the intriguing possibility that misfolded A? acts as a template for tau misfolding in vivo. PMID:22965142

Nussbaum, Justin M.; Seward, Matthew E.; Bloom, George S.

2013-01-01

183

Vibroacoustic disease.  

PubMed

Vibroacoustic disease (VAD) is a whole-body, systemic pathology, characterized by the abnormal proliferation of extra-cellular matrices, and caused by excessive exposure to low frequency noise (LFN). VAD has been observed in LFN-exposed professionals, such as, aircraft technicians, commercial and military pilots and cabin crewmembers, ship machinists, restaurant workers, and disk-jockeys. VAD has also been observed in several populations exposed to environmental LFN. This report summarizes what is known to date on VAD, LFN-induced pathology, and related issues. In 1987, the first autopsy of a deceased VAD patient was performed. The extent of LFN induced damage was overwhelming, and the information obtained is, still today, guiding many of the associated and ongoing research projects. In 1992, LFN-exposed animal models began to be studied in order to gain a deeper knowledge of how tissues respond to this acoustic stressor. In both human and animal models, LFN exposure causes thickening of cardiovascular structures. Indeed, pericardial thickening with no inflammatory process, and in the absence of diastolic dysfunction, is the hallmark of VAD. Depressions, increased irritability and aggressiveness, a tendency for isolation, and decreased cognitive skills are all part of the clinical picture of VAD. LFN is a demonstrated genotoxic agent, inducing an increased frequency of sister chromatid exchanges in both human and animal models. The occurrence of malignancies among LFN-exposed humans, and of metaplastic and displastic appearances in LFN-exposed animals, clearly corroborates the mutagenic outcome of LFN exposure. The inadequacy of currently established legislation regarding noise assessments is a powerful hindrance to scientific advancement. VAD can never be fully recognized as an occupational and environmental pathology unless the agent of disease--LFN--is acknowledged and properly evaluated. The worldwide suffering of LFN-exposed individuals is staggering and it is unethical to maintain this status quo. PMID:15273020

Branco, N A A Castelo; Alves-Pereira, M

2004-01-01

184

Alzheimer's disease: strategies for disease modification  

Microsoft Academic Search

Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve symptoms, but do not have profound disease-modifying effects. However, in recent years, several approaches aimed at inhibiting disease progression have advanced to clinical trials. Among these, strategies targeting the production and clearance of the amyloid-? peptide — a cardinal feature of Alzheimer's disease that is thought to

Martin Citron

2010-01-01

185

Cushing's disease.  

PubMed

Cushing's disease (CD) is caused by a pituitary tumor secreting corticotropin (ACTH), leading to cortisol excess. Patients with CD comprise approximately 70% of patients with endogenous Cushing's syndrome (CS). If the diagnosis and treatment are delayed, patients with CD may suffer the deleterious consequences of hypercortisolism, leading to significant morbidity and mortality. The diagnosis of CD is complex and includes two separate steps: establishing the presence of pathologic hypercortisolism and identifying the underlying cause. The management of CD usually includes transsphenoidal pituitary surgery (TSS) as the primary form of therapy. Pituitary surgery by the most experienced surgeons leads to remission of CD in 70-90% of patients. Recurrence of CD may occur in up to 25% of patients on long-term follow-up. Patients with recurrent CD may be treated with repeat TSS, radiation therapy to the pituitary with interim medical therapy (including steroidogenesis inhibitors, centrally acting agents or a glucocorticoid receptor antagonist) or bilateral adrenalectomy. Improvements in diagnosis and management of CD have led to higher patient survival. However, quality of life is impaired on long-term follow-up in some patients, even those in remission. Better understanding of the pathogenesis of CD may lead to the development of more effective therapies. PMID:25248590

Tritos, Nicholas A; Biller, Beverly M K

2014-01-01

186

Kimura's Disease  

PubMed Central

Kimuras disease is a chronic inflammatory disorder of unknown etiology. It is rare in the West, but endemic in Asia. It typically presents as solitary or multiple subcutaneous nodules, that slowly increase in size. The lesions are variably painful and pruritic. It often accompanied by regional lymphadenopathy, raised serum eosinophil counts, and markedly elevated serum immunoglobulin E levels. Histologically, the lesions are characterized by reactive lymphoid follicles with eosinophilic infiltration and an increased amount of postcapillary venules. The optimal treatment for KD remains controversial. Although the condition seldom resolves spontaneously, malignant transformation has not been reported to date, and the prognosis is good. We describe a male patient with a 4-year pruritic progressive “bump” in front of his left ear. On physical examination, the patient had 2 discrete lesions on the left side of his face near his ear. Postauricularly, there was a 3 × 5 cm erythematous to violaceous, indurated nodule. Preauricularly, there was a similar, but smaller cyst-like nodule. Punch biopsy showed a superficial and deep nodular and interstitial infiltrate, reactive lymphoid follicles with a dense infiltration of eosinophils and areas of eosinophilic follicle lysis. The patient received intralesional triamcinolone acetonide injections 10 mg/cc behind left ear with a good improvement. PMID:19718429

Guimaraes, Cláudia Savassi; Moulton-Levy, Natalie; Sapadin, Allen; Vidal, Claudia

2009-01-01

187

Alzheimer disease: An interactome of many diseases  

PubMed Central

Alzheimer Disease (AD) is an outcome as well as source of many diseases. Alzheimer is linked with many other diseases like Diabetes type 2, cholesterolemia, hypertension and many more. But how each of these diseases affecting other is still unknown to scientific community. Signaling Pathways of one disease is interlinked with other disease. But to what extent healthy brain is affected when any signaling in human body is disturbed is the question that matters. There is a need of Pathway analysis, Protein-Protein interaction (PPI) and the conserved interactome study in AD and linked diseases. It will be helpful in finding the potent drug or vaccine target in conscious manner. In the present research the Protein-Protein interaction of all the proteins involved in Alzheimer Disease is analyzed using ViSANT and osprey tools and pathway analysis further reveals the significant genes/proteins linking AD with other diseases. PMID:24753659

Rao, Balaji S.; Gupta, Krishna Kant; Karanam, Pujitha; Peruri, Anusha

2014-01-01

188

RARE DISEASES LIST  

EPA Science Inventory

The rare disease list includes rare diseases and conditions for which information requests have been made to the Office of Rare Diseases. A rare disease is defined as a disease or condition for which there are fewer than 200,000 affected persons alive in the United States. The Of...

189

Cardiac Disease in Chronic Obstructive Pulmonary Disease  

Microsoft Academic Search

The cardiac manifestations of chronic obstructive pulmonary disease (COPD) are numerous. Impairments of right ventricular dysfunction and pulmonary vascular disease are well known to complicate the clinical course of COPD and correlate inversely with survival. The pathogenesis of pulmonary vascular disease in COPD is likely multi- factorial and related to alterations in gas exchange and vascular biology, as well as

Jeremy A. Falk; Steven Kadiev; Gerard J. Criner; Steven M. Scharf; Omar A. Minai; Philip Diaz

2008-01-01

190

Alzheimer's Disease: The Death of the Disease.  

ERIC Educational Resources Information Center

Alzheimer's disease, a form of dementia in middle-age and older adults is becoming more evident because of growing numbers of older people and better diagnosis and detection methods. Describes the behavioral and physical symptoms of the disease as well as specific suggestions for care of patients with Alzheimer's disease, including dealing with…

McBroom, Lynn W.

1987-01-01

191

Vanishing White Matter Disease  

MedlinePLUS

What is Vanishing White Matter Disease? Vanishing White Matter Disease (VWM) is inherited in an autosomal recessive manner, meaning that it is a ... information about this). Other Clinical Names for Vanishing White Matter Disease Other clinical names of Vanishing White ...

192

Chronic obstructive pulmonary disease  

MedlinePLUS

COPD; Chronic obstructive airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... heart swelling and heart failure due to chronic lung disease) Pneumonia Pneumothorax Severe weight loss and malnutrition Thinning ...

193

Heart disease - resources  

MedlinePLUS

Resources - heart disease ... The following organizations are good resources for information on heart disease: American Heart Association - www.americanheart.org Centers for Disease Control and Prevention - www.cdc.gov/heartdisease/

194

Kidney disease - resources  

MedlinePLUS

Resources - kidney disease ... The following organizations are good resources for information on kidney disease: National Kidney Disease Education Program - www.nkdep.nih.gov National Kidney Foundation - www.kidney.org National ...

195

Sickle Cell Disease Quiz  

MedlinePLUS

... False: People with sickle cell disease cannot get malaria . a) True b) False 4. True or False: ... False: People with sickle cell disease cannot get malaria. FALSE People with sickle cell disease can get ...

196

Cardiovascular Disease and Diabetes  

MedlinePLUS

Cardiovascular Disease & Diabetes Updated:Jan 31,2013 The following statistics speak loud and clear that there is a strong correlation between cardiovascular disease (CVD) and diabetes. Heart diseases and stroke are ...

197

Parkinson disease - discharge  

MedlinePLUS

Your doctor has told you that you have Parkinson disease . This disease affects the brain and leads to ... have you take different medicines to treat your Parkinson disease and many of the problems that may come ...

198

Amyloidosis and Kidney Disease  

MedlinePLUS

... Info Statistics Research Resources About Us Espańol National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Failure Series : Amyloidosis and Kidney Disease Amyloidosis and Kidney Disease On this page: What is amyloidosis? What ...

199

Acquired Cystic Kidney Disease  

MedlinePLUS

... Info Statistics Research Resources About Us Espańol National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Failure Series : Acquired Cystic Kidney Disease Acquired Cystic Kidney Disease On this page: What is acquired cystic ...

200

Tay-Sachs disease  

MedlinePLUS

Tay-Sachs disease is a life-threatening disease of the nervous system passed down through families. ... Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found ...

201

Autoimmune liver disease panel  

MedlinePLUS

Liver disease test panel - autoimmune ... Autoimmune disorders are a possible cause of liver disease. The most common of these diseases are autoimmune hepatitis and primary biliary cirrhosis. This group of tests helps your health care provider ...

202

Carotid Artery Disease  

MedlinePLUS

... cerebrovascular disease, stroke, transient ischemic attacks (TIA) Carotid artery disease is a form of disease that affects ... to the brain by the 2 large carotid arteries in the front of your neck and by ...

203

Heart Disease in Women  

MedlinePLUS

... page from the NHLBI on Twitter. How Does Heart Disease Affect Women? Espańol In the United States, ... about coronary MVD and broken heart syndrome. Coronary Heart Disease CHD is a disease in which plaque ( ...

204

Hypothyroidism and Heart Disease  

MedlinePLUS

... and Heart Disease Share: Fact Sheet Hypothyroidism and Heart Disease January 2014 Download PDFs English Espanol Editors ... hormone. Why does hypothyroidism increase your risk for heart disease? Both thyroid hormones (T4 and T3) are ...

205

Types of Periodontal Disease  

MedlinePLUS

Types of Periodontal Disease Gingivitis Chronic Periodontitis Aggressive Periodontitis Periodontitis Caused by Conditions of the Body Necrotizing Periodontal Diseases Periodontal disease can refer to any condition that affects the gums and ...

206

Alzheimer's Disease Research Centers  

MedlinePLUS

... education.wisc.edu Back to Top Alzheimer's Disease Cooperative Study (ADCS) The ADCS conducts clinical trials on ... delay the onset of Alzheimer's disease. Alzheimer's Disease Cooperative Study University of California, San Diego 9500 Gilman ...

207

Polycystic Kidney Disease  

MedlinePLUS

... Z List of Topics and Titles : Polycystic Kidney Disease Polycystic Kidney Disease On this page: Autosomal Dominant PKD Autosomal Recessive ... Research Points to Remember For More Information Polycystic kidney disease (PKD) is a genetic disorder characterized by the ...

208

Heart disease and diet  

MedlinePLUS

Diet - heart disease ... diet and lifestyle can reduce your risk of: Heart disease, heart attacks, and stroke Conditions that lead to heart disease, including high cholesterol , high blood pressure, and obesity ...

209

Inflammation and Heart Disease  

MedlinePLUS

Inflammation and Heart Disease Updated:Jul 29,2014 Understand the risks of inflammation. Although it is not proven that inflammation causes cardiovascular disease, inflammation is common for heart disease and stroke patients and is thought to be ...

210

Mitochondrial Disease: Possible Symptoms  

MedlinePLUS

... Disease Possible Symptoms Getting a Diagnosis Treatments & Therapies Replacement Therapy EPI-743 Other Diseases Linked to Mitochondrial Disease ... Coordinators Ambassador Program NAMDC RDCRN Medical/Scientific Meetings Replacement Therapy EPI-743 Research Grants Grand Rounds National Symposium ...

211

HIV and Kidney Disease  

MedlinePLUS

... Select a Language: Fact Sheet 651 HIV and Kidney Disease WHY SHOULD PEOPLE WITH HIV CARE ABOUT KIDNEY ... disease. Kidney problems can lead to end-stage renal disease (ESRD) or kidney failure. This can require dialysis ...

212

About Alzheimer's Disease: Alzheimer's Basics  

MedlinePLUS

... with Alzheimer's disease? What is dementia? What is Alzheimer's disease? Alzheimer’s disease is an irreversible, progressive brain disease ... devastating disease. What happens to the brain in Alzheimer's disease? Although we still don’t know how the ...

213

Atheroembolic renal disease  

MedlinePLUS

Renal disease - atheroembolic; Cholesterol embolization syndrome; Atheroemboli - renal; Atherosclerotic disease - renal ... disorder of the arteries. It occurs when fat, cholesterol, and other substances build up in the walls ...

214

Biomarker for Glycogen Storage Diseases  

ClinicalTrials.gov

Fructose Metabolism, Inborn Errors; Glycogen Storage Disease; Glycogen Storage Disease Type I; Glycogen Storage Disease Type II; Glycogen Storage Disease Type III; Glycogen Storage Disease Type IV; Glycogen Storage Disease Type V; Glycogen Storage Disease Type VI; Glycogen Storage Disease Type VII; Glycogen Storage Disease Type VIII

2015-03-10

215

Interstitial Lung Diseases  

MedlinePLUS

Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and scarring make it hard to ... air is responsible for some types of interstitial lung diseases. Specific types include Black lung disease among ...

216

NEOPLASTIC DISEASES OF POULTRY  

Technology Transfer Automated Retrieval System (TEKTRAN)

Depending on whether the etiologic agent is known, neoplastic diseases of poultry are divided into two main categories: a) virus-induced neoplastic diseases, and b) neoplastic diseases of unknown etiology. Neoplastic diseases cause economic losses from tumor mortality as well as poor performance. Vi...

217

Tay-Sachs Disease  

MedlinePLUS

NINDS Tay-Sachs Disease Information Page Table of Contents (click to jump to sections) What is Tay-Sachs Disease? Is there ... Trials Organizations Additional resources from MedlinePlus What is Tay-Sachs Disease? Tay-Sachs disease is a fatal genetic lipid ...

218

Molecular Bioinformatics for Diseases  

E-print Network

. PNAS, 104: 8685 (2007). #12;Mendelian diseases E6V6 Sickle Cell Disease: Autosomal recessive disorder 4. Curr Opin Pediatr, 13: 22 (2001). Leads to sickle cell anemia Manifestation of disease vastly differentPSB 2009 Molecular Bioinformatics for Diseases Tutorial Atul Butte, Maricel Kann, Yves Lussier

Radivojac, Predrag

219

Fungal and Bacterial Diseases.  

Technology Transfer Automated Retrieval System (TEKTRAN)

Fungal and bacterial diseases are important constraints to production. Recognition of diseases and information on their biology is important in disease management. This chapter is aimed at providing diagnostic information on fungal and bacterial diseases of sugar beet and their biology, epidemiolo...

220

Plant Disease Lesson: Blackleg  

NSDL National Science Digital Library

This plant disease lesson on Blackleg (caused by Leptosphaeria maculans (teleomorph) Phoma lingam (anamorph).) includes information on symptoms and signs, pathogen biology, disease cycle and epidemiology, disease management, and the significance of the disease. Selected references are listed and a glossary is also available for use with this resource.

Gavin Ash (Charles Sturt University; )

2000-11-11

221

Disease model: LAMP2 enlightens Danon disease  

Microsoft Academic Search

Danon disease (‘lysosomal glycogen storage disease with normal acid maltase’) is characterized by a cardiomyopathy, myopathy and variable mental retardation. Mutations in the coding sequence of the lysosomal-associated membrane protein 2 (LAMP-2) were shown to cause a LAMP-2 deficiency in patients with Danon disease. LAMP-2 deficient mice manifest a similar vacuolar cardioskeletal myopathy. In addition to the patient reports LAMP-2

Paul Saftig; Kurt von Figura; Yshitaka Tanaka; Renate Lüllmann-Rauch

2001-01-01

222

Mycobacterial disease in patients with rheumatic disease  

Microsoft Academic Search

This Review focuses on the emergence of mycobacterial disease in patients undergoing treatment for rheumatic disease with four new drug classes—tumor necrosis factor (TNF) inhibitors, human interleukin (IL)-1 receptor antagonists, anti-CD20 antibodies and CD4+ T-cell costimulation modulators—collectively referred to as biologic agents. Mycobacterial disease is a major cause of severe infection in patients undergoing anti-TNF therapy. Reports are now emerging

Martin J Boeree; PN Richard Dekhuijzen; Dick van Soolingen; Jakko van Ingen

2008-01-01

223

Ecology of Infectious Diseases  

NSDL National Science Digital Library

A joint National Science Foundation (NSF) and National Institutes of Health program, Ecology of Infectious Diseases (EID), allows scientists to study how large-scale environmental events—such as habitat destruction, invasions of non-native species and pollution—alter the risks of emergence of viral, parasitic and bacterial diseases in humans and animals. Specific infectious diseases being studied include hantavirus, Lyme Disease, and Chronic Wasting Disease (CWD).

224

Renal cystic diseases  

Microsoft Academic Search

.   Renal cystic disease comprises a mixed group of heritable, developmental, and acquired disorders. Because of their diverse\\u000a etiology, histology, and clinical presentation, no single scheme of classification has gained acceptance. Conditions include\\u000a autosomal dominant polycystic kidney disease, acquired renal cystic disease, medullary sponge kidney, autosomal recessive\\u000a polycystic kidney disease, multicystic dysplastic kidney, medullary cystic disease, tuberous sclerosis, cysts of

H. S. Thomsen; E. Levine; J. W. Meilstrup; M. A. Van Slyke; K. A. Edgar; J. C. Barth; D. S. Hartman

1997-01-01

225

Oral Crohn's disease  

PubMed Central

’Crohn's disease’ is an inflammatory granulomatous disease of the gastrointestinal tract with extra-intestinal manifestations. Oral lesions may precede the intestinal disease and serve as a source for histological diagnosis. We present a case of orofacial Crohn's disease where orofacial symptoms were present for about 13 years and occasional constipation was present, since 6 months. Oral examination plays an important role in early diagnosis of Crohn's disease. PMID:25364165

Padmavathi, BN; Sharma, Smriti; Astekar, Madhusudan; Rajan, Y; Sowmya, GV

2014-01-01

226

Stages of Huntington's Disease (HD)  

MedlinePLUS

... Behavioral and Sexual Problems in Huntington's Disease Understanding Behavior in Huntington's Disease Caregiving A Caregiver's Handbook for Advanced-Stage Huntington's Disease Huntington's Disease at Mid-Stage Nursing Approaches for Clients with Huntington's Disease Long Term ...

227

Understanding Byssinosis (Brown Lung Disease)  

MedlinePLUS

... Disparities Reports Lung Disease Finder Lung Disease List Lung HelpLine Questions about your lung health? Need help ... ENews Home > Lung Disease > Byssinosis Understanding Byssinosis (Brown Lung Disease) What is Byssinosis? Byssinosis (brown lung disease) ...

228

Genetics Home Reference: Gaucher disease  

MedlinePLUS

... bone disease, and mild enlargement of the spleen (splenomegaly). How common is Gaucher disease? Gaucher disease occurs ... cerebroside lipidosis syndrome Gaucher's disease Gauchers disease Gaucher ... deficiency glucocerebrosidosis glucosylceramidase deficiency ...

229

At Risk for Kidney Disease?  

MedlinePLUS Videos and Cool Tools

... Kidney Disease Additional Kidney Information At Risk for Kidney Disease? You are at risk for kidney disease ... failure by treating kidney disease early. Diabetes and Kidney Disease Diabetes is the leading cause of kidney ...

230

Obesity and cardiovascular disease.  

PubMed

Cardiovascular disease is the most common cause of mortality in rich countries and today it has the same meaning for health care as the epidemics of past centuries had for medicine in earlier times: 50% of the population in these countries die of cardiovascular disease. The amount of cardiovascular disease is also increasing in the developing countries together with economic growth. By 2015 one in three deaths will globally be due to cardiovascular diseases. Coronary heart disease is a chronic disease that starts in childhood, even if the symptoms first occur in the middle age. The risks for coronary heart disease are well-known: lipid disorders, especially high serum LDL-cholesterol concentration, high blood pressure, tobacco smoking, obesity, diabetes, male gender and physical inactivity. Obesity is both an independent risk factor for cardiovascular disease but is also closely connected with several other risk factors. This review focuses on the connection between overweight or obesity and cardiovascular disease. PMID:25387321

Jokinen, E

2015-03-01

231

Coronary Artery Disease - Coronary Heart Disease  

MedlinePLUS

... High Blood Pressure website Take our Blood Pressure Risk Assessment Physical inactivity An inactive lifestyle is a risk ... our Nutrition website Learn more: What Are My Risks for Heart Disease Infographic Take the MyLifeCheck ® Assessment Top 10 Myths about Cardiovascular Disease Tracking Your ...

232

Prion Diseases as Transmissible Zoonotic Diseases  

PubMed Central

Prion diseases, also called transmissible spongiform encephalopathies (TSEs), lead to neurological dysfunction in animals and are fatal. Infectious prion proteins are causative agents of many mammalian TSEs, including scrapie (in sheep), chronic wasting disease (in deer and elk), bovine spongiform encephalopathy (BSE; in cattle), and Creutzfeldt–Jakob disease (CJD; in humans). BSE, better known as mad cow disease, is among the many recently discovered zoonotic diseases. BSE cases were first reported in the United Kingdom in 1986. Variant CJD (vCJD) is a disease that was first detected in 1996, which affects humans and is linked to the BSE epidemic in cattle. vCJD is presumed to be caused by consumption of contaminated meat and other food products derived from affected cattle. The BSE epidemic peaked in 1992 and decreased thereafter; this decline is continuing sharply owing to intensive surveillance and screening programs in the Western world. However, there are still new outbreaks and/or progression of prion diseases, including atypical BSE, and iatrogenic CJD and vCJD via organ transplantation and blood transfusion. This paper summarizes studies on prions, particularly on prion molecular mechanisms, BSE, vCJD, and diagnostic procedures. Risk perception and communication policies of the European Union for the prevention of prion diseases are also addressed to provide recommendations for appropriate government policies in Korea. PMID:24159531

Lee, Jeongmin; Kim, Su Yeon; Hwang, Kyu Jam; Ju, Young Ran; Woo, Hee-Jong

2013-01-01

233

Periodontal Disease and Coronary Heart Disease  

Microsoft Academic Search

The epidemiological cohort randomized studies have demonstrated an association between periodontal disease and coronary heart disease. The study was conducted on 241 subjects with verified CHD from a Department of Cardiology and 50 subject without CHD from Govt. Dental College PGIMS, Rohtak. Information on diabetic states, smoking habits, alcohol consumption and lipid profile was obtained. Full month probing depth, clinical

Balwant Rai; Jasdeep Kaur; R. K Jain; S. C. Anand

234

Epidemiology: Understanding Disease Spread  

NSDL National Science Digital Library

Factors that influence disease spread throughout populations can be explored with the program Epidemiology. Both population and disease characteristics can be modeled over different time periods. The Susceptible- Infected- Recovered (SIR) model enables us to make predictions based on significant variables such as the flow of new susceptibles in to the population, transmission rates, disease deaths, and the duration of the disease. Ebola is used as a model organism and epidemiology is presented from both a microbiological and social perspective. * build epidemiological models of different diseases, design strategies for disease control, and test the effectiveness of these strategies on virtual populations

Marion Fass (Beloit College; Biology)

2006-05-20

235

Lyme Disease Research  

NSDL National Science Digital Library

Maine Medical Center Research Institute's Lyme Disease Research Laboratory provides this website focusing on ticks and the control of tick-borne diseases. This site is divided into several sections. The first section "Tick Borne Diseases" contains resources on diseases caused by tick-borne pathogens, such as Lyme disease. "Prevention & Control" gives site visitors information on avoiding tick bites, and removal of ticks from the body. Links to other sites and key sources of information on ticks and Lyme disease can be found in the "Other Resources" section.

236

Working Memory in Mild Alzheimer's Disease and Early Parkinson's Disease  

E-print Network

Working Memory in Mild Alzheimer's Disease and Early Parkinson's Disease Elizabeth A. Kensinger of Technology Alzheimer's disease (AD) and Parkinson's disease (PD) impair working memory (WM). It is unclear an expanding interest in how neurological diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD

Corkin, Suzanne

237

About Thyroid Disease  

Cancer.gov

Noncancerous Thyroid DiseaseSome thyroid diseases are caused by changes in the amount of thyroid hormones that enter the body from the thyroid gland. Doctors can screen for these with a simple blood test.

238

Facts about Crohn's Disease  

MedlinePLUS

... and Drug Administration MAY 2, 2008 What is Crohn’s Disease? • It is a chronic inflammatory condition of ... Cimzia to treat adults with moderate to severe Crohn’s Disease who have not responded to conventional therapies. ...

239

Genetics and Lung Disease  

MedlinePLUS

... Society What should I know about genetics and lung disease? If you compare the genes of a group ... your risk of getting asthma. For a few lung diseases, genes play a much bigger role. These are ...

240

Cat Scratch Disease  

MedlinePLUS

Cat scratch disease (CSD) is an illness caused by the bacterium Bartonella henselae. Almost half of all cats carry the infection ... symptoms of CSD, call your doctor. Centers for Disease Control and Prevention

241

Pelvic Inflammatory Disease  

MedlinePLUS

Pelvic inflammatory disease (PID) is an infection and inflammation of the uterus, ovaries, and other female reproductive organs. It causes scarring ... United States. Gonorrhea and chlamydia, two sexually transmitted diseases, are the most common causes of PID. Other ...

242

Bile Duct Diseases  

MedlinePLUS

... carry the bile to your small intestine. Different diseases can block the bile ducts and cause a ... liver failure. A rare form of bile duct disease called biliary atresia occurs in infants. It is ...

243

Carotid Artery Disease  

MedlinePLUS

... brain with blood. If you have carotid artery disease, the arteries become narrow, usually because of atherosclerosis. ... one of the causes of stroke. Carotid artery disease often does not cause symptoms, but there are ...

244

Peripheral Arterial Disease  

MedlinePLUS

Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of ... smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, ...

245

Degenerative Nerve Diseases  

MedlinePLUS

Degenerative nerve diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many of these diseases are genetic. Sometimes the cause is a medical ...

246

Creutzfeldt-Jakob Disease  

MedlinePLUS

Creutzfeldt-Jakob disease (CJD) is a rare, degenerative brain disorder. Symptoms usually start around age 60. Memory problems, behavior changes, vision ... during a medical procedure Cattle can get a disease related to CJD called bovine spongiform encephalopathy (BSE) ...

247

Sexually Transmitted Diseases  

MedlinePLUS

Sexually transmitted diseases (STDs) are infections that you can get from having sex with someone who has the infection. The causes ... is no cure. Sometimes medicines can keep the disease under control. Correct usage of latex condoms greatly ...

248

Creutzfeldt-Jakob disease  

MedlinePLUS

... be the same one that causes vCJD in humans. Varient CJD causes less than 1% of all ... Scrapie (found in sheep) Other very rare inherited human diseases, such as Gerstmann-Straussler-Scheinker disease and ...

249

Liver disease - resources  

MedlinePLUS

Resources - liver disease ... The following organizations are good resources for information on liver disease : American Liver Foundation - www.liverfoundation.org Children's Liver Association for Support Services - www.classkids.org Hepatitis ...

250

Lyme Disease Transmission  

MedlinePLUS

... infected ticks. The blacklegged tick (or deer tick, Ixodes scapularis ) spreads the disease in the northeastern, mid- ... central United States, and the western blacklegged tick ( Ixodes pacificus ) spreads the disease on the Pacific Coast. ...

251

Diagnosis of Parasitic Diseases  

MedlinePLUS

... under a microscope, parasitic diseases such as filariasis, malaria, or babesiosis, can be diagnosed. This test is ... source: Global Health - Division of Parasitic Diseases and Malaria Notice: Linking to a non-federal site does ...

252

Diseases and Their Management  

Technology Transfer Automated Retrieval System (TEKTRAN)

Important diseases and their management practices of lentil were reviewed. The diseases reveiwed include Ascochyta blight (Ascochyta lentis), Anthracnose (Colletotrichum truncatum), White mold (Sclerotinia sclerotiorum), rust (Uromyces viciae-fabae), Botrytis gray mold (Botrytis cinerea and B. faba...

253

Learning about Your Disease  

MedlinePLUS

... transplant can treat SCID Transplant outcomes for SCID Sickle cell disease (SCD) Symptoms of SCD How transplant ... NHL) Severe aplastic anemia Severe combined immunodeficiency (SCID) Sickle cell disease (SCD) Wiskott-Aldrich syndrome If you ...

254

Polycystic kidney disease  

MedlinePLUS

Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD ... Polycystic kidney disease (PKD) is passed down through families (inherited), usually as an autosomal dominant trait. If one parent ...

255

Tay-Sachs Disease  

MedlinePLUS

Tay-Sachs disease is a rare, inherited disorder. It causes too much of a fatty substance to build up ... cells, causing mental and physical problems. Infants with Tay-Sachs disease appear to develop normally for the first few ...

256

Von Willebrand disease  

MedlinePLUS

Von Willebrand disease is the most common hereditary bleeding disorder . ... Von Willebrand disease is caused by a deficiency of von Willebrand factor. Von Willebrand factor helps blood platelets clump together ...

257

Kidney and Urologic Diseases  

MedlinePLUS

... and CKD (for health care professionals) Blood Urea Nitrogen (BUN) (from MedlinePlus) Bone Disease of Kidney Failure ... Enlargement: Benign Prostatic Hyperplasia ) BUN (See Blood Urea Nitrogen ) C Calcitriol (See Chronic Kidney Disease-Mineral and ...

258

Alcoholic liver disease  

MedlinePLUS

Liver disease due to alcohol; Cirrhosis or hepatitis - alcoholic; Laennec's cirrhosis ... Alcoholic liver disease occurs after years of heavy drinking. Alcohol can cause inflammation in the liver . Over time, scarring ...

259

Progression of Liver Disease  

MedlinePLUS

... Handouts Education Resources Support Services Helpful Links For Liver Health Information Call 1-800-GO-LIVER (1- ... The Progression of Liver Disease The Progression of Liver Disease There are many different types of liver ...

260

Treatments for Alzheimer's Disease  

MedlinePLUS

... 3900 Find your chapter: search by state Home > Alzheimer's Disease > Treatments Overview What Is Dementia? What Is Alzheimer's? ... and move closer to a cure. Treatments for Alzheimer's disease Get weekly e-news Take the Brain Tour ...

261

Coronary Artery Disease  

MedlinePLUS

Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death ... both men and women. CAD happens when the arteries that supply blood to heart muscle become hardened ...

262

Carotid Artery Disease  

MedlinePLUS

... from the NHLBI on Twitter. What Is Carotid Artery Disease? Carotid (ka-ROT-id) artery disease is ... blood to your face, scalp, and neck. Carotid Arteries Figure A shows the location of the right ...

263

What Is Castleman Disease?  

MedlinePLUS

... documents Hodgkin Disease and Non-Hodgkin Lymphoma .) About lymph nodes and lymphoid tissue To understand Castleman disease, it ... found in many places throughout the body, including: Lymph nodes: bean-sized collections of lymphocytes found in small ...

264

Pediatric Celiac Disease  

MedlinePLUS

... serious condition caused by a permanent intolerance for gluten--a protein found in wheat, rye, and barley. Pediatric Celiac Disease If your child has celiac disease, consuming gluten will cause damage to finger-like projections, called ...

265

Learning about Huntington's Disease  

MedlinePLUS

... Mouse Models Of Huntington's Disease 1998 News Release Learning About Huntington's Disease What do we know about ... and treatment information. Hosted by the Dolan DNA Learning Center at Cold Spring Harbor Laboratory. Huntington's Outreach ...

266

Eye Disease Simulations  

MedlinePLUS

... Research at NEI Education Programs Training and Jobs Eye Disease Simulations Listen Age-Related Macular Degeneration Cataract ... information page Back to top Diabetic Retinopathy Diabetic Eye Disease information page Back to top Glaucoma Glaucoma ...

267

Women and Heart Disease  

MedlinePLUS

... this? Submit What's this? Submit Button Related CDC Web Sites Heart Disease Stroke High Blood Pressure Salt ... this? Submit What's this? Submit Button Related CDC Web Sites Heart Disease Stroke High Blood Pressure Salt ...

268

Men and Heart Disease  

MedlinePLUS

... this? Submit What's this? Submit Button Related CDC Web Sites Heart Disease Stroke High Blood Pressure Salt ... this? Submit What's this? Submit Button Related CDC Web Sites Heart Disease Stroke High Blood Pressure Salt ...

269

Living with Heart Disease  

MedlinePLUS

... page from the NHLBI on Twitter. Living With Heart Disease If you have coronary heart disease (CHD), ... it harder for you to make lifestyle changes. Heart Attack Warning Signs If you have CHD, learn ...

270

What Causes Heart Disease?  

MedlinePLUS

... page from the NHLBI on Twitter. What Causes Heart Disease? Research suggests that coronary heart disease (CHD) ... Red: Eileen's Story 10/14/2014 Celebrating American Heart Month: NIH Advancing Heart Research 10/14/2014 ...

271

Heart Disease Risk Factors  

MedlinePLUS

... this? Submit What's this? Submit Button Related CDC Web Sites Division for Heart Disease and Stroke Prevention ... this? Submit What's this? Submit Button Related CDC Web Sites Division for Heart Disease and Stroke Prevention ...

272

Head Lice: Disease  

MedlinePLUS

... Treatment FAQs Malathion FAQs Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ... Frequently Asked Questions (FAQs) Epidemiology & Risk Factors Disease Biology Diagnosis Treatment Prevention & Control Resources for Health Professionals ...

273

Diseases and Conditions  

MedlinePLUS

... Wars & Operations Exposure Categories A-Z Index Agent Orange Agent Orange Home Facts about Herbicides Veterans' Diseases Birth Defects ... Veterans Health Initiative Veterans Health Initiative Home Agent Orange Gulf War Infectious Diseases of Southwest Asia War ...

274

Kidney Disease of Diabetes  

MedlinePLUS

... ACE) inhibitors and angiotensin receptor blockers (ARBs), have proven effective in slowing the progression of kidney disease. ... ACE) inhibitors and angiotensin receptor blockers (ARBs), have proven effective in slowing the progression of kidney disease. ...

275

Pregnancy and Fifth Disease  

MedlinePLUS

... Cheek Rash Parvovirus B19 and Other Illnesses References Pregnancy and Fifth Disease Recommend on Facebook Tweet Share ... with fifth disease. Testing for Parvovirus B19 During Pregnancy A blood test for parvovirus B19 can show ...

276

Travelers' Health: Meningococcal Disease  

MedlinePLUS

... meningococcal disease in returning pilgrims and their contacts. Map 3-11. Areas with frequent epidemics of meningococcal meningitis View Larger Map PDF Version (printable) CLINICAL PRESENTATION Meningococcal disease generally ...

277

Lewy Body Disease  

MedlinePLUS

... is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough ... be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body ...

278

Minimal change disease  

MedlinePLUS

... microscope. It can only be seen under an electron microscope. Minimal change disease is the most common ... biopsy and examination of the tissue with an electron microscope can show signs of minimal change disease. ...

279

Modeling Infectious Diseases  

MedlinePLUS

... gov/Research/SpecificAreas/MIDAS . Learn more: Now Trending: Mining Historical Data on Infectious Diseases Computing Diseases from ... reviewed November 2014 Share Print E-mail House Image Highlight Header Highlight Body Related Links Up to ...

280

Metabolic Diseases of Muscle  

MedlinePLUS

... disease. 9 Metabolic Diseases of Muscle • ©2011 MDA Lactate dehydrogenase deficiency Also called: Glycogenosis type 11 Onset: ... rash is common, probably because skin cells need lactate dehydrogenase. FAt-PRoCEssing disoRdERs Carnitine deficiency Onset: Childhood ...

281

Cholesterol and Heart Disease  

MedlinePLUS

... right-hand corner of the player. Cholesterol and Heart Disease HealthDay February 5, 2015 Related MedlinePlus Pages Cholesterol Heart Diseases Transcript When should you start worrying about your ...

282

Plasmapheresis and Autoimmune Disease  

MedlinePLUS

... the booklet in this Web page . Plasmapheresis and Autoimmune Disease Many diseases, including myasthenia gravis, Lambert-Eaton ... and others, are caused by a so-called autoimmune, or self-immune, process. In autoimmune conditions, the ...

283

Lipid Storage Diseases  

MedlinePLUS

... although Gaucher and Fabry diseases have highly effective enzyme replacement therapies. There is currently no cure for Niemann-Pick ... NINDS researchers were responsible for developing highly effective enzyme replacement therapies for Gaucher and Fabry diseases. Scientists at the ...

284

Lung disease - resources  

MedlinePLUS

... gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html Emphysema/COPD (Chronic Obstructive Pulmonary Disease): COPD Foundation - www.copdfoundation.org National Emphysema Foundation - www.emphysemafoundation.org National Heart, Lung, and ...

285

About Alzheimer's Disease: Causes  

MedlinePLUS

... changes in the brain One of the great mysteries of Alzheimer’s disease is why it largely strikes ... read the section from Alzheimer's Disease: Unraveling the Mystery , "Looking for the Causes of AD" NIA Information ...

286

Anemia of chronic disease  

MedlinePLUS

... ulcerative colitis Cancer , including lymphoma and Hodgkin disease Chronic kidney disease Long-term infections, such as bacterial endocarditis, osteomyelitis (bone infection), HIV/AIDS , hepatitis B or hepatitis C

287

Chronic Kidney Diseases  

MedlinePLUS

... for a long time, doctors call it a chronic kidney disease. Children's kidney problems may be congenital (say: kun- ... Do Doctors Treat Kidney Problems? The treatment for chronic kidney ... bone disease. Sometimes unhealthy kidneys have problems producing a hormone ...

288

Associated Autoimmune Diseases  

MedlinePLUS

... a qualified physician for an evaluation. Insulin Dependent Diabetes Mellitus (Type 1 Diabetes) A disease of the pancreas. The coincidence of type 1 diabetes and celiac disease is 8 - 10 %.Often the ...

289

Cat scratch disease (image)  

MedlinePLUS

Cat scratch disease is an infectious illness associated with cat scratches, bites, or exposure to cat saliva, causing chronic swelling of the lymph nodes. Cat scratch disease is possibly the most common cause of chronic ...

290

Parallelization: Infectious Disease  

NSDL National Science Digital Library

Epidemiology is the study of infectious disease. Infectious diseases are said to be "contagious" among people if they are transmittable from one person to another. Epidemiologists can use models to assist them in predicting the behavior of infectious diseases. This module will develop a simple agent-based infectious disease model, develop a parallel algorithm based on the model, provide a coded implementation for the algorithm, and explore the scaling of the coded implementation on high performance cluster resources.

Aaron Weeden

291

Soybean Diseases Atlas.  

E-print Network

quality seed is a major cause of seedling disease. Inadequate stands, lack of uniform stands and death of young seedlings are characteristics of seedling disease. Damage may occur before the seed germinates or emerges, or young plants may die after... seedling emergence. The presence of dark brown or reddish lesions on the stem and lower main root confirms seedling disease. How ever, microscopic examination of the damaged tissue is sometimes necessary to identify specific disease pathogens involved...

Anonymous,

1979-01-01

292

Peyronie’s Disease  

Microsoft Academic Search

Peyronie’s disease is an enigmatic disease characterized by penile curvature, penile pain, and erectile dysfunction. The disease\\u000a appears to be more prevalent than previously thought as more men seek medical attention for sexual complaints. The lack of\\u000a a clear pathogenetic mechanism for the disease has led to numerous, diverse treatment options. Inconsistent results from studies\\u000a evaluating these various treatment options,

J. Slade Hubbard; Culley C. Carson

293

Major Histocompatibility Complex: Disease  

E-print Network

Major Histocompatibility Complex: Disease Associations Chester A Alper, Harvard Medical School at least a third of normal European Caucasian MHC haplotypes and contribute most of the MHC disease susceptibility genetic markers. Whereas this has facilitated the detection of MHC gene-disease association

Alper, Chester A.

294

Diverticular Disease and Diverticulitis  

Microsoft Academic Search

Diverticular disease is one of the most prevalent medical conditions to affect Western populations. Symptomatic diverticular disease can range from mild, low-level symptomatology similar to that seen in irritable bowel syndrome to acute bouts of diverticulitis complicated by abscess or frank perforation. This review discusses the epidemiology, pathophysiology, clinical presentation, and management of the spectrum of diverticular disease, including mention

Anish A. Sheth; Walter Longo; Martin H. Floch

2008-01-01

295

What's Mad Cow Disease?  

MedlinePLUS

... System How the Body Works Main Page What's Mad Cow Disease? KidsHealth > Kids > Q&A > Q & A > What's Mad Cow Disease? Print A A A Text Size ... Do? You might have heard news reports about mad cow disease and wondered: What the heck is ...

296

Deer: Wasting Disease Disaster.  

NSDL National Science Digital Library

Chronic wasting disease, the brain disease sometimes compared to mad cow disease that affects deer and elk, has become a problem outside of the states of Colorado and Wyoming where it has been known for decades, raising awareness and concern for wildlife in affected areas. This Web site is a recent Why Files discussing the epidemic and Wisconsin's plans to control it.

2002-01-01

297

BACTERIAL KIDNEY DISEASE  

Technology Transfer Automated Retrieval System (TEKTRAN)

Bacterial kidney disease (BKD), caused by Renibacterium salmoninarum, is a prevalent disease that impacts the sustainable production of salmonid fish for consumption and species conservation efforts. The disease is chronic in nature and mortality most often occurs in 6–12 month old juvenile salmonid...

298

Heart Disease in Women  

MedlinePLUS

... United States, 1 in 4 women dies from heart disease. The most common cause of heart disease in both men and women is narrowing ... the blood vessels that supply blood to the heart itself. This is called coronary artery disease, and ...

299

Dysphagia in systemic disease  

Microsoft Academic Search

Dysphagia, difficulty in swallowing sometimes accompanied by a sensation of food sticking, is a common symptom resulting from structural and\\/or motility disorders of the oropharynx and esophagus which may result from local factors or occur as one of the manifestations of a systemic disease process. In this review, “systemic disease” will include diseases that affect more than one organ or

Bronwyn Jones; William J. Ravich; Martin W. Donner

1993-01-01

300

About Alzheimer's Disease: Diagnosis  

MedlinePLUS

... health issue is causing the problem. How is Alzheimer’s disease diagnosed? A definitive diagnosis of Alzheimer’s disease can ... Clinical Trials Database . What new methods for diagnosing Alzheimer’s disease are being studied? Scientists are exploring ways to ...

301

Disease and their management.  

Technology Transfer Automated Retrieval System (TEKTRAN)

This chapter reviews diseases of chickpea and their management practices. Some of the most important disease such as Ascochyta blight, Fuarium wilt, Botrytis gray mold, are described in detail. The life cycle and epidemiology of these diseases are discussed in relation to the management practices. ...

302

Menopause and Heart Disease  

MedlinePLUS

Menopause and Heart Disease Updated:Oct 1,2013 Heart disease risk rises for everyone as they age, but for women symptoms can ... women is seen about 10 years after menopause. Heart disease is the leading killer of women . Estrogen Levels ...

303

Travel and Heart Disease  

MedlinePLUS

Travel and Heart Disease Updated:Nov 11,2014 Travel precautions help people with heart disease. Traveling to a faraway place doesn’t need to be off limits because you have heart disease or are a caretaker of someone who has ...

304

Vector-Borne Diseases  

NSDL National Science Digital Library

This online encyclopedia article discusses vector-borne diseases. It defines vectors as the transmitters of disease-causing organisms that carry the pathogens from one host to another. The article reviews the biological range of vectors, the transmission and types of vector-borne diseases, patterns of occurrence and existing control measures.

Harvey Artsob

305

Venereal Disease. Second Edition.  

ERIC Educational Resources Information Center

This book is one in a series of contemporary topics in health science for students. The first chapter deals with the behavioral aspects of venereal disease and how the disease has been affected by our changing society. Chapter 2 discusses the magnitude of the problem, presenting various maps and charts. The history of venereal disease and the…

Bender, Stephen J.

306

Anemia of renal disease  

Microsoft Academic Search

Patient group It is estimated that 15–30% of geriatric cats will develop chronic kidney disease (CKD), and that 30–65% of these cats will develop anemia as their renal disease worsens. Anemia of renal disease is multifactorial in its pathogenesis, but the main cause is reduced production of erythropoietin, a renal hormone that controls the bone marrow's production of red blood

Cathy E. Langston; Adam Eatroff

2011-01-01

307

Childhood Contagious Diseases  

MedlinePLUS

... or viruses (such as in chickenpox, measles, hand-foot-and-mouth disease, and quite a few others) in droplets ... it is most commonly seen in children. Hand-Foot-and-Mouth Disease Hand-foot-and-mouth disease is a ...

308

Alzheimers disease Neurodegeneration  

E-print Network

Keywords Alzheimer´s disease Neurodegeneration Cell cycle and apoptosis » Prof. Dr. Thomas Arendt The research group is working on the pathomechanism of Alzheimer´s disease and related of the cholinergic ba- sal forebrain system in Alzheimer´s disease which provides the basis for the currently

SchĂĽler, Axel

309

Cardiovascular Disease (CVD) Coronary heart disease  

E-print Network

have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

Dever, Jennifer A.

310

HIV and Cardiovascular Disease (Heart Disease)  

MedlinePLUS Videos and Cool Tools

... which can place added strain on the heart. Kidney failure Although research is continuing on this topic, ... people living with HIV have higher risks for kidney disease. Your kidneys are very important to your ...

311

Skin Diseases: Skin Health and Skin Diseases  

MedlinePLUS

... diseases and immune system problems can cause dermatitis, hives, and other skin conditions. Many skin problems, such ... rely on information about you and your family. Hives —Red and sometimes itchy bumps on your skin. ...

312

Genetics Home Reference: Hirschsprung disease  

MedlinePLUS

... 2 Genetic Testing Registry: Hirschsprung disease 3 Genetic Testing Registry: Hirschsprung disease 4 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition: Hirschsprung's Disease ...

313

Cardiovascular Diseases (and Oral Health)  

MedlinePLUS

Cardiovascular Diseases Periodontal Disease and Cardiovascular Conditions Heart Disease and Dental Treatment Myocardial Infarction (Heart Attack) High Blood Pressure (Hypertension) Coronary Artery Bypass Graft (CABG) Angina High ...

314

Genetics Home Reference: Pompe disease  

MedlinePLUS

... treatment providers. Baby's First Test Gene Review: Glycogen Storage Disease Type II (Pompe Disease) Genetic Testing Registry: Glycogen storage disease, type II You might also find information ...

315

Lyme disease in athletes.  

PubMed

Lyme disease, a bacterial infection transmitted by ticks, is the most common vector-borne disease in the northern hemisphere. Athletes who train or compete in wooded environments in endemic regions are at increased risk of contracting Lyme disease. Variability in clinical presentation, masquerading symptoms, and limitations in testing may lead to misdiagnosis. Early diagnosis and treatment result in full recovery for most patients with Lyme disease; however symptoms may persist for months to years, especially when diagnosis is delayed. This article reviews the epidemiology, clinical manifestations, diagnosis, treatment, and prevention of Lyme disease, with focus on the athletic population. PMID:25574885

DuPrey, Kevin M

2015-01-01

316

Creutzfeldt--Jakob disease.  

PubMed Central

The laboratory transmission to animals of an apparently degenerative disease of the nervous system, Creutzfeldt-Jakob disease (CJD), is now well established. Important questions arising from this observation are the possibility of natural transmission or infectivity and the existence of other similarly transmissible diseases. Epidemiological studies have revealed some possible clusters of CJD and also an association with previous craniotomy, but there is no definite evidence of natural infection. A few instances have been reported of experimental CJD in animals following inoculation with material from Alzheimer's disease, but apart from this there is so far no evidence of transmission of any other form of degenerative nervous disease. PMID:103082

Matthews, W. B.

1978-01-01

317

Behçet's disease as a systemic disease.  

PubMed

Behçet's disease usually begins with cutaneous manifestations, such as recurrent aphthous stomatitis, genital ulcers, erythema nodosum-like lesions, papulopustular findings, and pathergy phenomenon. Recurrent aphthous stomatitis is generally the first sign, and other findings may develop in the course of the disease. There is no specific diagnostic available for Behçet's disease. It is most prevalent among patients along the ancient Silk Road. The high frequency of HLA-B51 among a wide range of ethnic populations favors the role of genetic factors. Behçet's disease usually appears in the third to fourth decade of life, and is rarely seen in children and adults over 50 years of age. It affects both genders equally, but the course of the disease is more severe in men. Eye involvement leading to loss of vision, plus vascular, articular, and central nervous system involvement are more commonly observed among men. Behçet's disease is a systemic inflammatory disorder. A complex genetic background, coupled with innate and adaptive immune system activation, causes the diverse clinical manifestations that characterize the clinical picture. PMID:24767193

Mat, M Cem; Sevim, Ay?egül; Fresko, Izzet; Tüzün, Yalç?n

2014-01-01

318

Structural imaging biomarkers of Alzheimer's disease: predicting disease progression  

E-print Network

1 Structural imaging biomarkers of Alzheimer's disease: predicting disease the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (www of Alzheimer's disease (AD) may allow earlier detection and refined pre- diction

Paris-Sud XI, Université de

319

Heart Disease, Stroke, or Other Cardiovascular Disease and Adult Vaccination  

MedlinePLUS

... Vaccination Home Recommended Vaccines for Adults Share Compartir Heart Disease, Stroke, or Other Cardiovascular Disease and Adult Vaccination ... critical for people with health conditions such as heart disease, stroke, or other cardiovascular disease. If you have ...

320

Genetics Home Reference: Refsum disease  

MedlinePLUS

... Refsum disease? adult Refsum disease ARD classic Refsum disease CRD hereditary motor and sensory neuropathy Type IV heredopathia atactica ... Professionals What glossary definitions help with understanding Refsum disease? acids ; anosmia ; ... leukodystrophy ; motor ; neuropathy ; oxidation ; peripheral ; peroxisomes ; ...

321

FastStats: Kidney Disease  

MedlinePLUS

... Diseases and Conditions Anemia or Iron Deficiency Cancer Cancer Prostate Disease Cardiovascular Cerebrovascular Disease or Stroke Cholesterol Heart ... States, 2013, table 97 [PDF - 9.8 MB] > Incidence and prevalence of end-stage renal disease Health, United States, ...

322

Genetics of Proteasome Diseases  

PubMed Central

The proteasome is a large, multiple subunit complex that is capable of degrading most intracellular proteins. Polymorphisms in proteasome subunits are associated with cardiovascular diseases, diabetes, neurological diseases, and cancer. One polymorphism in the proteasome gene PSMA6 (?8C/G) is associated with three different diseases: type 2 diabetes, myocardial infarction, and coronary artery disease. One type of proteasome, the immunoproteasome, which contains inducible catalytic subunits, is adapted to generate peptides for antigen presentation. It has recently been shown that mutations and polymorphisms in the immunoproteasome catalytic subunit PSMB8 are associated with several inflammatory and autoinflammatory diseases including Nakajo-Nishimura syndrome, CANDLE syndrome, and intestinal M. tuberculosis infection. This comprehensive review describes the disease-related polymorphisms in proteasome genes associated with human diseases and the physiological modulation of proteasome function by these polymorphisms. Given the large number of subunits and the central importance of the proteasome in human physiology as well as the fast pace of detection of proteasome polymorphisms associated with human diseases, it is likely that other polymorphisms in proteasome genes associated with diseases will be detected in the near future. While disease-associated polymorphisms are now readily discovered, the challenge will be to use this genetic information for clinical benefit. PMID:24490108

Gomes, Aldrin V.

2013-01-01

323

Genetics of proteasome diseases.  

PubMed

The proteasome is a large, multiple subunit complex that is capable of degrading most intracellular proteins. Polymorphisms in proteasome subunits are associated with cardiovascular diseases, diabetes, neurological diseases, and cancer. One polymorphism in the proteasome gene PSMA6 (-8C/G) is associated with three different diseases: type 2 diabetes, myocardial infarction, and coronary artery disease. One type of proteasome, the immunoproteasome, which contains inducible catalytic subunits, is adapted to generate peptides for antigen presentation. It has recently been shown that mutations and polymorphisms in the immunoproteasome catalytic subunit PSMB8 are associated with several inflammatory and autoinflammatory diseases including Nakajo-Nishimura syndrome, CANDLE syndrome, and intestinal M. tuberculosis infection. This comprehensive review describes the disease-related polymorphisms in proteasome genes associated with human diseases and the physiological modulation of proteasome function by these polymorphisms. Given the large number of subunits and the central importance of the proteasome in human physiology as well as the fast pace of detection of proteasome polymorphisms associated with human diseases, it is likely that other polymorphisms in proteasome genes associated with diseases will be detected in the near future. While disease-associated polymorphisms are now readily discovered, the challenge will be to use this genetic information for clinical benefit. PMID:24490108

Gomes, Aldrin V

2013-01-01

324

[Autoimmune thyroid disease and associated diseases].  

PubMed

Autoimmune thyroid disease (ATD) is a multifactorial, genetic disease. It is the sequelae of the impaired immunoregulation, tolerance and poor recognition of one's own proteins, oligopolysaccharides and polypeptides, due to development of somatic lymphocyte mutations. It is manifested by different clinical and morphological entities, inter-related by etiopathogenetic association, i.e., all of them are caused by disorder of immune system regulation. Chronic autoimmune thyroidism (Thyreoiditis lymphocytaria Hashimoto, HT), as well as immunogenic hyperthyroidism (Morbus Graves Basedow, MGB) are frequently associated with autoimmune diseases of other organs, such as: chronic insufficiency of salivary glands (Sy Sjögren), autoimmune hemolytic anemia, megalocytic pernicious anemia, thrombocytopenia, Rheumatoid arthritis, Diabetes mellitus (more often type 2, but also type 1), Morbus Addison, Coeliakia, and other autoimmune diseases such as systemic diseases of connecting tissue (Lupus erythematosus-SLE, Sclerodermia, Vasculitis superficialis). The incidence of autoimmune diseases has been at increase in all age groups of our population. The prevalence of organ-specific and organ-nonspecific antibodies increases with the age. Antigenicity of thyroid epithelial cell may be triggered by different chemical and biological agents (repeated viral infections), repeated stress, and in individuals with genetic propensity. Unrecognized ATD progressively leads to hypothyroidism with hyperlipidemia, blood vessel changes, osteoporosis, deformities, invalidity which substantially reduces the quality of life of patient and requires medical attention and expensive treatment on what account it is medically and socio-economically significant. Multiple diagnostic procedures contribute to faster recognition of this condition. The goal of the primary health care physician (given that preclinical phase of ATD and other associated diseases have different duration) and other specialists is to recognize ATD and, by early diagnosis and multidisciplinary treatment, to take secondary preventive measures of manifestation of above-mentioned associated autoimmune diseases, and in that way, to avoid the development of comorbidity and complications. It is particularly supported by medical doctrine based on evidence of application of corticosteroids, cytostatics, thyro-suppressive and substitution therapy, antilipemics, bisphosphonates and other drugs, significant for autoimmune diseases. PMID:16405263

Lapcevi?, Mirjana

2005-10-01

325

Occupational Disease in Connecticut, 2014  

E-print Network

...........................................................................................................20 Respiratory Illness and Poisonings ...........................................................................................24 E. Occupational Disease Surveillance System: Physicians' Reports................................................................................................................30 Lung/Respiratory Diseases and Poisonings

Oliver, Douglas L.

326

Epigenetic inheritance of disease and disease risk.  

PubMed

Epigenetic marks in an organism can be altered by environmental factors throughout life. Although changes in the epigenetic code can be positive, some are associated with severe diseases, in particular, cancer and neuropsychiatric disorders. Recent evidence has indicated that certain epigenetic marks can be inherited, and reshape developmental and cellular features over generations. This review examines the challenging possibility that epigenetic changes induced by environmental factors can contribute to some of the inheritance of disease and disease risk. This concept has immense implications for the understanding of biological functions and disease etiology, and provides potential novel strategies for diagnosis and treatment. Examples of epigenetic inheritance relevant to human disease, such as the detrimental effects of traumatic stress or drug/toxic exposure on brain functions, are reviewed. Different possible routes of transmission of epigenetic information involving the germline or germline-independent transfer are discussed, and different mechanisms for the maintenance and transmission of epigenetic information like chromatin remodeling and small noncoding RNAs are considered. Future research directions and remaining major challenges in this field are also outlined. Finally, the adaptive value of epigenetic inheritance, and the cost and benefit of allowing acquired epigenetic marks to persist across generations is critically evaluated. PMID:22781843

Bohacek, Johannes; Mansuy, Isabelle M

2013-01-01

327

Epigenetic Inheritance of Disease and Disease Risk  

PubMed Central

Epigenetic marks in an organism can be altered by environmental factors throughout life. Although changes in the epigenetic code can be positive, some are associated with severe diseases, in particular, cancer and neuropsychiatric disorders. Recent evidence has indicated that certain epigenetic marks can be inherited, and reshape developmental and cellular features over generations. This review examines the challenging possibility that epigenetic changes induced by environmental factors can contribute to some of the inheritance of disease and disease risk. This concept has immense implications for the understanding of biological functions and disease etiology, and provides potential novel strategies for diagnosis and treatment. Examples of epigenetic inheritance relevant to human disease, such as the detrimental effects of traumatic stress or drug/toxic exposure on brain functions, are reviewed. Different possible routes of transmission of epigenetic information involving the germline or germline-independent transfer are discussed, and different mechanisms for the maintenance and transmission of epigenetic information like chromatin remodeling and small noncoding RNAs are considered. Future research directions and remaining major challenges in this field are also outlined. Finally, the adaptive value of epigenetic inheritance, and the cost and benefit of allowing acquired epigenetic marks to persist across generations is critically evaluated. PMID:22781843

Bohacek, Johannes; Mansuy, Isabelle M

2013-01-01

328

Aging as disease.  

PubMed

In this paper, I will argue that ageing can be construed as disease. First, the concept of disease is discussed, where the distinction is made between two lines of thought, an objectivist and a subjectivist one. After determining the disease conception to be used throughout the argument, it is proposed that senescence could be seen as disease. Three common counterarguments are discussed, none of which appears strong enough to effectively counter the advocated view. In the third section, two potential implications of the view advocated here will be briefly touched upon. These are the quest for a cure or treatment for ageing and the general attitude towards the elderly. It is concluded that, utilizing an objective disease concept, ageing could be seen as a disease. None of the considered counterarguments packs enough of a punch to discard this. The implications are complex and intertwined, but need not be negative. PMID:25240472

De Winter, Gunnar

2015-05-01

329

Viral Disease Networks?  

NASA Astrophysics Data System (ADS)

Viral infections induce multiple perturbations that spread along the links of the biological networks of the host cells. Understanding the impact of these cascading perturbations requires an exhaustive knowledge of the cellular machinery as well as a systems biology approach that reveals how individual components of the cellular system function together. Here we describe an integrative method that provides a new approach to studying virus-human interactions and its correlations with diseases. Our method involves the combined utilization of protein - protein interactions, protein -- DNA interactions, metabolomics and gene - disease associations to build a ``viraldiseasome''. By solely using high-throughput data, we map well-known viral associated diseases and predict new candidate viral diseases. We use microarray data of virus-infected tissues and patient medical history data to further test the implications of the viral diseasome. We apply this method to Epstein-Barr virus and Human Papillomavirus and shed light into molecular development of viral diseases and disease pathways.

Gulbahce, Natali; Yan, Han; Vidal, Marc; Barabasi, Albert-Laszlo

2010-03-01

330

Collecting rare diseases  

PubMed Central

This editorial introduces the F1000Research rare disease collection. It is common knowledge that for new treatments to be successful there has to be a partnership between the many interested parties such as the patient, advocate, disease foundations, the academic scientists, venture funding organizations, biotech companies, pharmaceutical companies, NIH, and the FDA. Our intention is to provide a forum for discussion and dissemination of any rare disease related topics that will advance scientific understanding and progress to treatments. PMID:25580231

Ekins, Sean

2014-01-01

331

Genes and Disease  

NSDL National Science Digital Library

The National Center for Biotechnology Information of the National Library of Medicine (part of the National Institutes of Health) has posted this webpage, Genes and Disease, which provides information "for some 60 diseases associated with specific genes, and has links to the 1998 Gene Map as well as to PubMed, protein sequences, Online Mendelian Inheritance in Man, and associations related to each disease."

1998-01-01

332

Heart Valve Disease  

Microsoft Academic Search

\\u000a This chapter was designed to provide the reader with a brief overview of the current surgical treatment options for heart\\u000a valve disease. Major topics of discussion are: (1) development of prosthetic valve replacements; (2) current issues with valve\\u000a replacement; (3) major valvular diseases that affect humans in the Western world; and (4) recent advances in therapeutic options\\u000a for valvular diseases.

Ranjit John; Kenneth K. Liao

333

Acquired von Willebrand Disease  

Microsoft Academic Search

Acquired von Willebrand disease (AvWD) is a rare complication of an autoimmune or neoplastic disease. It is associated mostly with a lymphoid or plasma cell proliferative disorder. The clinical manifestations are similar to congenital von Willebrand disease. Diagnosis is confirmed by the demonstration of decreased levels of factor VIII coagulant activity (VIII:C), ristocetin cofactor activity (vWF:RCo), and von Willebrand factor

Ayalew Tefferi; William L Nichols

1997-01-01

334

Apathy in Parkinson's disease  

PubMed Central

Objective: To assess apathy in patients with Parkinson's disease and its relation to disability, mood, personality, and cognition. Methods: Levels of apathy in 45 patients with Parkinson's disease were compared with a group of 17 similarly disabled patients with osteoarthritis. Additional neuropsychiatric data were collected concerning levels of depression, anxiety, and hedonic tone. Personality was assessed with the tridimensional personality questionnaire. Cognitive testing included the mini-mental state examination, the Cambridge examination of cognition in the elderly, and specific tests of executive functioning. Results: Patients with Parkinson's disease had significantly higher levels of apathy than equally disabled osteoarthritic patients. Furthermore, within the Parkinson sample, levels of apathy appear to be unrelated to disease progression. The patients with Parkinson's disease with the highest levels of apathy where not more likely to be depressed or anxious than those with the lowest levels of apathy, though they did show reduced hedonic tone. No differences in personality traits were detected in comparisons between patients with Parkinson's disease and osteoarthritis, or between patients in the Parkinson group with high or low levels of apathy. As a group, the patients with Parkinson's disease tended not to differ significantly from the osteoarthritic group in terms of cognitive skills. However, within the Parkinson's disease sample, the high apathy patients performed significantly below the level of the low apathy patients. This was particularly evident on tests of executive functioning. Conclusions: Apathy in Parkinson's disease is more likely to be a direct consequence of disease related physiological changes than a psychological reaction or adaptation to disability. Apathy in Parkinson's disease can be distinguished from other psychiatric symptoms and personality features that are associated with the disease, and it is closely associated with cognitive impairment. These findings point to a possible role of cognitive mechanisms in the expression of apathy. PMID:12438462

Pluck, G; Brown, R

2002-01-01

335

Cushing’s disease  

Microsoft Academic Search

Cushing’s disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with\\u000a significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are\\u000a therefore mandatory. First step of the diagnostic work-up is the endogenous glucocorticoid excess by measurement of urinary\\u000a free cortisol, cortisol circadian rhythmicity or suppression by low doses

Martina De Martin; Francesca Pecori Giraldi; Francesco Cavagnini

2006-01-01

336

Zoonotic Diseases Tutorial  

NSDL National Science Digital Library

This website from the University of Wisconsin, features an exhausting list of zoonotic diseases (those that can be shared by both animals and humans). Each disease has its own devoted sub-page, which discusses the particular disease in detail. A healthy list of related websites is also maintained on the lower half of the main page. The website is very minimalist, but this clean and well-organized site is extremely valuable and easy to navigate.

Olsen, Christopher W.

337

Neurofilamentopathy in Neurodegenerative Diseases  

PubMed Central

Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented. PMID:21915226

Liu, Quan; Xie, Fang; Alvarado-Diaz, Abdiel; Smith, Mark A; Moreira, Paula I; Zhu, Xiongwei; Perry, George

2011-01-01

338

Obesity and cardiovascular disease  

Microsoft Academic Search

Obesity is a major contributor to the prevalence of cardiovascular disease in the developed world, and yet has only recently\\u000a been afforded the same level of attention as other risk factors of coronary artery disease. Obesity is a chronic metabolic\\u000a disorder associated with cardiovascular disease and increased morbidity and mortality. It is apparent that a variety of adaptations\\/alterations\\u000a in cardiac

Paul Poirier; Robert H. Eckel

2002-01-01

339

Cerebrovascular Disease and Disorders  

Microsoft Academic Search

\\u000a Cerebrovascular diseases are a common cause of cognitive impairment in adults and a clinically significant cause of cognitive\\u000a disability in children. Ischemic and hemorrhagic stroke are the main types of cerebrovascular disease. Risk factors for stroke,\\u000a clinical signs and symptoms, diagnostic evaluation and treatment are discussed for each category of cerebrovascular disease,\\u000a and differences across the life span are highlighted.

Sabrina E. Smith; Juliana Sanchez Bloom; Nancy Minniti

340

Coronary Heart Disease  

MedlinePLUS

... Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ...

341

Kidney Disease (Nephropathy)  

MedlinePLUS

... Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ...

342

Peri-Implant Diseases  

MedlinePLUS

... Comprehensive Periodontal Evaluation Periodontal Treatments and Procedures Non-Surgical Periodontal Treatments Gum Graft Surgery Laser Treatment for Gum Disease Regenerative Procedures Dental Crown ...

343

Gum Disease Symptoms  

MedlinePLUS

... Comprehensive Periodontal Evaluation Periodontal Treatments and Procedures Non-Surgical Periodontal Treatments Gum Graft Surgery Laser Treatment for Gum Disease Regenerative Procedures Dental Crown ...

344

Gum Disease and Women  

MedlinePLUS

... Comprehensive Periodontal Evaluation Periodontal Treatments and Procedures Non-Surgical Periodontal Treatments Gum Graft Surgery Laser Treatment for Gum Disease Regenerative Procedures Dental Crown ...

345

Enterobiasis (Pinworm Infection): Disease  

MedlinePLUS

... General Information Pinworm Infection FAQs Epidemiology & Risk Factors Biology Disease Diagnosis Treatment Prevention & Control Resources for Health Professionals Publications Information For: Travelers ...

346

Kidney Disease of Diabetes  

NSDL National Science Digital Library

The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service provided by a related department of the National Institutes of Health (NIH). Visitors will find that the NKUDIC website has a special page on Kidney Disease of Diabetes which includes articles on the homepage about "The Course of Kidney Disease", "Preventing and Slowing Kidney Disease", and "Good Care Makes a Difference". On the left side of the homepage visitors will find some very interesting research timelines by the NIH, titled "Yesterday, Today and Tomorrow". There is a timeline for "Chronic Kidney Disease and Kidney Failure", "Diabetes, Type 1", and "Diabetes, Type 2". The "Yesterday" section explain to visitors the past methods of treating the disease, as well as past statistics about death and diseases caused by diabetes. The "Today" section explains how the disease is treated presently, and how statistics have improved regarding survival and occurrence of diabetes-related disease. Finally, the "Tomorrow" section highlights research studies that aim to improve the lives of diabetics, and interested visitors will find links to relevant websites.

347

Medullary cystic kidney disease  

MedlinePLUS

Anemia Bone weakening and fractures Cardiac tamponade Changes in glucose metabolism Congestive heart failure End-stage kidney disease Gastrointestinal bleeding, ulcers Hemorrhage (excessive bleeding) High ...

348

Creativity and neurological disease.  

PubMed

Although humans have long valued creativity, the generation of such innovation is still incompletely understood. Looking at the healthy brain, researchers have localized certain parts for a basic understanding of these mechanisms. By researching the brain affected by neurological disease, scientists have observed unique manifestations of creativity, such as in frontotemporal lobar degeneration, Alzheimer's disease, Parkinson's disease and parkinsonian spectrum disorders, and stroke, which help clarify these creative underpinnings. Incorporating both healthy and disease models of cerebral functioning, neurological and neuroscientific research from recent years has built on established theories and expanded current knowledge. PMID:24938215

Acosta, Lealani Mae Y

2014-08-01

349

Pelvic Inflammatory Disease  

MedlinePLUS

... PID treated? • How can PID be prevented? • Glossary Pelvic Inflammatory Disease Upper reproductive tract Fallopian tubes The Female Reproductive System Ovaries Uterus Cervix Vagina Lower reproductive tract Who ...

350

Gorham's disease of femur  

PubMed Central

Gorham's disease is a rare condition of bones characterized by spontaneous massive and progressive osteolysis. Less than 200 cases have been reported so far. Femur is an uncommon site of Gorham disease. We report a young female, presenting as pathological fracture of the femur, wherein rapid osteolysis of femur occurred. The clinical, pathological, and radiological picture suggested a diagnosis of Gorham's disease. The patient was subjected to radiotherapy (40 Gys) and put on bisphosphonates. At a follow-up of 2 years, the disease process had stopped and partial recalcification of the bone had occurred. PMID:22144753

Baba, Asif Nazir; Bhat, Yasmeen J; Paljor, Simon D; Nazir, Abid; Khan, Nazir A

2011-01-01

351

Multiple Cystic Lung Disease  

PubMed Central

A lung cyst is an air-filled lucent structure surrounded by a thin wall. The presence of multiple intrapulmonary cysts is defined as cystic lung disease. Although cystic lung disease is rare, incidental detection has increased significantly in recent years by screening using computed tomography. There are many conditions that can mimic lung cysts and cause cystic lung disease. Clinical, radiographic, and histologic findings are all necessary for a proper diagnosis, and multidisciplinary approaches are frequently required. The aim of this report is to review the causes and characteristics of cystic lung disease to better understand and improve treatment. PMID:23579924

Yoo, Chul-Gyu

2013-01-01

352

Paraneoplastic muscle disease.  

PubMed

In paraneoplastic muscle disease, the malignancy may remotely affect neuromuscular transmission or incite muscle inflammation or necrosis. In several of these diseases, an autoimmune basis for the muscle disease has been established and has become a defining feature. These paraneoplastic muscle diseases may be the first manifestation of a malignancy, and their diagnosis thus demands a vigilant search for an underlying tumor. This article is focused on inflammatory and necrotizing myopathies and disorders of neuromuscular transmission that may arise in the setting of malignancy and are considered paraneoplastic phenomena. PMID:21444019

Baer, Alan N

2011-05-01

353

Genetics of hepatobiliary diseases.  

PubMed

With the recent publication of the first human map of genetic variation (ie, Human Haplotype Map), genomic-based discoveries will likely affect not only the research bench but also the bedside. These advances will improve the understanding of the genetics of hepatobiliary diseases, resulting in better prevention measures and diagnosis as well as more effective therapies. Currently, alcoholic liver disease, nonalcoholic fatty liver disease, and symptomatic gallbladder stones affect a sizable portion of the population. On the other hand, chronic cholestatic liver diseases, hepatocellular carcinoma, and polycystic liver disease, although rare, shorten life expectancy and diminish the quality of life of patients. In the genomic era, we have the opportunity to start dissecting the susceptibility genetic variants of liver diseases. We are now in a position to begin elucidating the complex genotype/phenotype relationships of liver diseases with the anticipation to understand disease pathogenesis better. These efforts will require the application of genomic-based approaches in large well-organized translational studies in the diseases of interest. PMID:16678073

Juran, Brian D; Lazaridis, Konstantinos N

2006-05-01

354

Chronic thyroiditis (Hashimoto disease)  

MedlinePLUS

Hashimoto thyroiditis; Chronic lymphocytic thyroiditis; Autoimmune thyroiditis ... cases, the condition is called type 2 polyglandular autoimmune syndrome (PGA II). Less commonly, Hashimoto disease occurs ...

355

Moyamoya disease: Diagnostic imaging  

PubMed Central

Summary Moyamoya disease is a progressive vasculopathy leading to stenosis of the main intracranial arteries. The incidence of moyamoya disease is high in Asian countries; in Europe and North America, the prevalence of the disease is considerably lower. Clinically, the disease may be of ischaemic, haemorrhagic and epileptic type. Cognitive dysfunction and behavioral disturbance are atypical symptoms of moyamoya disease. Characteristic angiographic features of the disease include stenosis or occlusion of the arteries of the circle of Willis, as well as the development of collateral vasculature. Currently, magnetic resonance angiography and CT angiography with multi-row systems are the main imaging methods of diagnostics of the entire range of vascular changes in moyamoya disease. The most common surgical treatment combines the direct arterial anastomosis between the superficial temporal artery and middle cerebral, and the indirect synangiosis involving placement of vascularised tissue in the brain cortex, in order to promote neoangiogenesis. Due to progressive changes, correct and early diagnosis is of basic significance in selecting patients for surgery, which is the only effective treatment of the disease. An appropriate qualification to surgery should be based on a comprehensive angiographic and imaging evaluation of brain structures. Despite the rare occurrence of moyamoya disease in European population, it should be considered as one of causes of ischaemic or haemorrhagic strokes, especially in young patients. PMID:22802820

Tarasów, Eugeniusz; Ku?akowska, Alina; ?ukasiewicz, Adam; Kapica-Topczewska, Katarzyna; Korneluk-Sadzy?ska, Alicja; Brzozowska, Joanna; Drozdowski, Wies?aw

2011-01-01

356

Lyme disease and conservation  

USGS Publications Warehouse

Lyme disease is a tick-borne illness that is wide-spread in North America, especially in the northeastern and northcentral United States. This disease could negatively influence efforts to conserve natural populations in two ways: (1) the disease could directly affect wild animal health; and (2) tick control efforts could adversely affect natural populations and communities. Lyme disease affects several domestic animals, but symptoms have been reported in only a few wild species. Direct effects of Lyme disease on wild animal populations have not been reported, but the disease should be considered as a possible cause in cases of unexplained population declines in endemic areas. Methods available to manage ticks and Lyme disease include human self-protection techniques, manipulation of habitats and hosts species populations, biological control, and pesticide applications. The diversity of available techniques allows selection of approaches to minimize environmental effects by (1) emphasizing personal protection techniques, (2) carefully targeting management efforts to maximize efficiency, and (3) integrating environmentally benign techniques to improve management while avoiding broad-scale environmentally destructive approaches. The environmental effects of Lyme disease depend, to a large extent, on the methods chosen to minimize human exposure to infected ticks. Conservation biologists can help design tick management programs that effectively lower the incidence of human Lyme disease while simultaneously minimizing negative effects on natural populations.

Ginsberg, H.

1994-01-01

357

[Crohn's disease: a controversy].  

PubMed

In 1932, the New York City-based gastroenterologist, Burril B. Crohn, published the manuscript 'Regional Ileitis' in The Journal of the American Medical Association (JAMA). This publication is responsible for the current designation of Crohn's disease. Despite the fact that this ground-breaking article lead to the improved description and recognition of this gastrointestinal disease, the choice for the name Crohn's disease was not always straightforward. This article discusses the controversy between Crohn and his colleagues Ginzburg and Oppenheimer, about the naming of the disease. In addition, it touches on the recognition of phenotypes that vary from Crohn's original depiction. PMID:25761291

Colman, R J

2015-01-01

358

Plant Disease / July 2002 813813 Disease Notes  

E-print Network

phaseoli from Lima Bean in Delaware. T. A. Evans, C. R. Davidson, J. D. Dominiak, R. P. Mulrooney, and R. B important disease of lima bean (Phaseolus lunatus L.) on the east coast of the United States. It has been a serious threat to commercial lima bean production in Delaware, Maryland, and New Jersey for the past 5

California at Berkeley, University of

359

Disease management in chronic kidney disease.  

PubMed

Chronic kidney disease (CKD) is a growing health problem of epidemic proportions both in the United States and worldwide. The care of CKD patients, before and after starting dialysis, remains highly fragmented resulting in suboptimal clinical outcomes and high costs, creating a high burden of disease on patients and the health care system. Disease management (DM) is an approach to coordinating care for this complex population of patients that has the promise of improving outcomes and constraining costs. For CKD patients not yet on dialysis, the major goals of a DM program are (1) early identification of CKD patients and therapy to slow the progression of CKD, (2) identification and management of the complications of CKD per se, (3) identification and management of the complications of comorbid conditions, and (4) smooth transition to renal replacement therapy. For those CKD patients on dialysis, focused attention on avoidable hospitalizations is a key to a successful DM program. Multidisciplinary collaboration among physicians (nephrologist, primary care physician, cardiologist, endocrinologist, vascular surgeons, and transplant physicians) and participating caregivers (nurse, pharmacist, social worker, and dietician) is critical as well. There are several potential barriers to the successful implementation of a CKD/end-stage renal disease DM program, including lack of awareness of the disease state among patients and health care providers, late identification and referrals to a nephrologist, complex fragmented care delivered by multiple providers in many different sites of care, and reimbursement that does not align incentives for all involved. Recent experience suggests that these barriers can be overcome, with DM becoming a promising approach for improving outcomes for this vulnerable population. PMID:18155106

Rastogi, Anjay; Linden, Ariel; Nissenson, Allen R

2008-01-01

360

Dysarthria in Friedreich disease.  

PubMed

Perceptual judgments have previously been used to rate the speech of patients with Friedreich disease. This study attempted to define speech patterns of dysarthria in Friedreich disease using acoustic analyses. The results from 14 patients indicated sudden variations in fundamental frequency and intensity, variability of segment durations, slowness of speech, and low diadochokinetic rate. PMID:2346881

Gentil, M

1990-04-01

361

Lipid Storage Diseases  

MedlinePLUS

... the enzyme beta-hexosaminidase. The GM2 disorders include: Tay-Sachs disease (also known as GM2 gangliosidosis-variant B). Tay- ... rarer form of the disorder, called late-onset Tay-Sachs disease, occurs in patients in their twenties and early ...

362

[Infectious diseases research].  

PubMed

There has been a significant increase in research activity into infectious diseases in Spain in the last few years. The Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) currently has ten study groups, with the cooperation of infectious diseases specialists and microbiologists from different centres, with significant research activity. The program of Redes Temáticas de Investigación Cooperativa en Salud (Special Topics Cooperative Health Research Networks) is an appropriate framework for the strategic coordination of research groups from the Spanish autonomous communities. The Spanish Network for Research in Infectious Diseases (REIPI) and the Network for Research in AIDS (RIS) integrate investigators in Infectious Diseases from multiple groups, which continuously perform important research projects. Research using different experimental models in infectious diseases, in numerous institutions, is an important activity in our country. The analysis of the recent scientific production in Infectious Diseases shows that Spain has a good position in the context of the European Union. The research activity in Infectious Diseases carried out in our country is a great opportunity for the training of specialists in this area of knowledge. PMID:19195467

Carratalŕ, Jordi; Alcamí, José; Cordero, Elisa; Miró, José M; Ramos, José Manuel

2008-12-01

363

Flying with Respiratory Disease  

Microsoft Academic Search

Patients with respiratory diseases may be at risk during flight because at cruising altitude an important hypobaric hypoxia may occur. The only absolute contraindications to flying in these patients are pneumothorax, bronchogenic cyst and severe pulmonary hypertension. In order to evaluate the risks related to air travel in patients with respiratory diseases, an evaluation of their fitness to fly, including

Panagiota Tzani; Giovanna Pisi; Marina Aiello; Dario Olivieri; Alfredo Chetta

2010-01-01

364

Chronic Disease Indicators  

NSDL National Science Digital Library

The Chronic Disease Indicators (CDI) is a cross-cutting set of 97 indicators that were developed by consensus and that allows states and territories and large metropolitan areas to uniformly define, collect, and report chronic disease data that are important to public health practice and available for states, territories and large metropolitan areas. 

Center for Disease Control

365

Crohn's disease and pregnancy  

Microsoft Academic Search

Infertility and the outcome of pregnancy has been examined in 112 married women with Crohn's disease who were below the age of 45 years. Fifty four patients were available for study. The infertility rate (12%) was similar to that seen in the general population. Patients who had active disease at the time of conception continued to have symptoms and they

R Khosla; C P Willoughby; D P Jewell

1984-01-01

366

Advances in Alzheimer's disease  

Microsoft Academic Search

The problem of the etiology of Alz- heimer's disease has not been solved. But in the past several years there have been significant extensions of our knowledge of the disease and advances in determining the molecular changes underlying the disorder. There is now convincing evidence that the dementia per se is caused by loss of neurons and synapses, particularly in

ROBERT KATZMAN; TSUNAO SAI

367

Gum and Heart Disease  

NSDL National Science Digital Library

Scientists have long noticed a connection between gum disease and heart disease. Now, they've found a key piece of the puzzle. This science update examines what scientists have found linking the total amount of periodontal bacteria in the mouth and blockages in the carotid artery.

Science Update

2005-04-25

368

What Is Batten Disease  

MedlinePLUS

... How does the disease progress? Genotype/phenotype correlations Classical CLN1 disease, infantile Babies are healthy and develop ... the electron microscope level. Does it have any alternative name? CLN2 ... by medicines for several months but always recur, becoming difficult ...

369

Sphingolipid metabolism diseases  

Microsoft Academic Search

Human diseases caused by alterations in the metabolism of sphingolipids or glycosphingolipids are mainly disorders of the degradation of these compounds. The sphingolipidoses are a group of monogenic inherited diseases caused by defects in the system of lysosomal sphingolipid degradation, with subsequent accumulation of non-degradable storage material in one or more organs. Most sphingolipidoses are associated with high mortality. Both,

Thomas Kolter; Konrad Sandhoff

2006-01-01

370

Gaucher disease and bone  

Microsoft Academic Search

Gaucher disease (GD) is an inherited lysosomal storage disorder affecting multiple organs. Non-neuronopathic GD, the most common form, can present with hepatosplenomegaly, anaemia, bleeding tendencies, thrombocytopenia, skeletal pathologies, growth retardation and, in severe cases, with pulmonary disease. The bone manifestations include bone infarcts, avascular bone necrosis, lytic lesions, osteosclerosis, fractures due to osteoporosis and, rarely, acute osteomyelitis. Bone pain of

P. Mikosch

371

Respiratory Diseases of Poultry  

Technology Transfer Automated Retrieval System (TEKTRAN)

A new Respiratory Diseases of Poultry CRIS will be established effective October 1, 2006. Initially, the disease agents to be studied will include Ornithobacterium rhinotracheale (ORT), Bordetella avium (BART) and Pasteurella multocida. The research will focus on development of more effective vacc...

372

Treating Skin Disease  

Microsoft Academic Search

Latino migrant and seasonal farmworkers experience high rates of skin disease that result from their working and living conditions. Knowledge of the ways farmworkers treat skin disease symptoms will provide a foundation for developing culturally appropriate health education, improving the delivery of health services, and improving occupational health policy for agricultural workers. The purpose of this paper is to describe

Thomas A. Arcury; Quirina M. Vallejos; Steven R. Feldman; Sara A. Quandt

2006-01-01

373

Waterborne diseases in Peru  

Microsoft Academic Search

The cholera epidemic in Peru brought to light the miserable state of local water and sanitation conditions. The author discusses the relationship between waterbone diseases and water and sewerage conditions in Peruvian peri-urban areas, or pueblos jovenes. These diseases are associated with poor living conditions. In 1989, only 52 percent of the population had access to piped water, and only

Sheila Webb

1992-01-01

374

Kidney Disease of Diabetes  

E-print Network

Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse The Burden of Kidney Failure Each year in the United States, more than 100,000 people are diagnosed with kidney failure, a serious condition in which the kidneys fail to rid the body of wastes.1 Kidney failure

Baker, Chris I.

375

Carotid Artery Disease  

MedlinePLUS

... away from the heart to the head and brain. Located on each side of the neck, these arteries can easily be felt pulsating by ... arteries, are located along the back of the neck adjacent to the spine, and supply blood to the back of the brain. What is carotid artery disease? Carotid artery disease ...

376

Ribosomopathies: Mechanisms of Disease  

PubMed Central

Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information. PMID:25512719

Nakhoul, Hani; Ke, Jiangwei; Zhou, Xiang; Liao, Wenjuan; Zeng, Shelya X; Lu, Hua

2014-01-01

377

Mummy berry disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Mummy Berry is the most important disease of blueberry worldwide. It has not been as severe in the southeastern U.S. on rabbiteye blueberry has it is in other areas on highbush blueberry. However, it has caused severe losses on some farms in some years. This poster gives the symptoms, disease cyc...

378

Pelvic Inflammatory Disease (PID)  

MedlinePLUS

... Douche; Use an intrauterine device (IUD) for birth control. Back to Top How can I reduce my risk of getting PID? The only way to avoid STDs is to ... Ti?ng Vięt (Vietnamese) Contact Us: Centers for Disease Control and ... Disease (PID) Facts & Brochures Fact Sheet Detailed Fact Sheet ...

379

Vegetable Diseases Purdue extension  

E-print Network

at the earliest threat of disease. Because the downy mildew fungus cannot overwinter in soil or crop residue, crop are the most likely crop to suffer yield damage from this disease. That's because pumpkins are grown late lesions on the undersides of the leaves may be covered with spores that appear as a dark fuzz (Figure 2

380

Niemann-Pick Disease  

MedlinePLUS

... group of inherited metabolic disorders known as lipid storage diseases. Lipids (fatty materials such as waxes, fatty acids, oils, and cholesterol) and proteins are usually broken down into smaller components to provide energy for the body. In Niemann-Pick disease, harmful ...

381

Von Gierke disease  

MedlinePLUS

... which the body cannot break down glycogen for energy. Gycogen is stored in the liver and muscles and is normally broken down into glucose when you do not eat. Von Gierke disease is also called Type I glycogen storage disease (GSD I).

382

Mycobiota in gastrointestinal diseases.  

PubMed

New insights gained through the use of state-of-the-art technologies, including next-generation sequencing, are starting to reveal that the association between the gastrointestinal tract and the resident mycobiota (fungal community) is complex and multifaceted, in which fungi are active participants influencing health and disease. Characterizing the human mycobiome (the fungi and their genome) in healthy individuals showed that the gastrointestinal tract contains 66 fungal genera and 184 fungal species, with Candida as the dominant fungal genera. Although fungi have been associated with a number of gastrointestinal diseases, characterization of the mycobiome has mainly been focused on patients with IBD and graft-versus-host disease. In this Review, we summarize the findings from studies investigating the relationship between the gut mycobiota and gastrointestinal diseases, which indicate that fungi contribute to the aggravation of the inflammatory response, leading to increased disease severity. A model explaining the mechanisms underlying the role of the mycobiota in gastrointestinal diseases is also presented. Our understanding of the contribution of the mycobiota to health and disease is still in its infancy and leaves a number of questions to be addressed. Answering these questions might lead to novel approaches to prevent and/or manage acute as well as chronic gastrointestinal disease. PMID:25385227

Mukherjee, Pranab K; Sendid, Boualem; Hoarau, Gautier; Colombel, Jean-Frédéric; Poulain, Daniel; Ghannoum, Mahmoud A

2015-02-01

383

Nickle and plant disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Knowledge of the nutritional physiology of nickel (Ni) is relatively meager. Accumulating evidence indicates that attention to management of Ni nutrition may potentially benefit yield, quality, disease resistance, and disease control of certain crop species, most notably those transporting ureido-ni...

384

Smoking and Periodontal Disease  

Microsoft Academic Search

Numerous investigations of the relationship between smoking and periodontal disease have been performed over the last 15 years, and there now exists a substantial body of literature upon which this current review is based. From both cross-sectional and longitudinal studies, there appears to be strong epidemiological evidence that smoking confers a considerably increased risk of periodontal disease. This evidence is

D. F. Kinane; I. G. Chestnutt

2000-01-01

385

Foodborne Disease Epidemiologist  

ERIC Educational Resources Information Center

The Centers for Disease Control and Prevention estimates that 76 million cases of foodborne illness occur in the U.S. each year; 5,000 are fatal. Most of these illnesses are caused by a variety of bacteria, viruses, and parasites and the remaining are poisonings triggered by harmful toxins or chemicals. To Jack Guzewich, a foodborne disease

Sullivan, Megan

2005-01-01

386

Gastroesophageal Reflux Disease (GERD)  

MedlinePLUS

... reflux disease , more commonly known as GERD or acid reflux. GERD doesn't just affect older people who eat too much while watching TV. Active, healthy teens can have GERD, too. What Is GERD? Gastroesophageal (pronounced: gas-tro-ih-sah-fuh-JEE-ul) reflux disease ...

387

Renal Stone Disease  

Microsoft Academic Search

Background\\/Aims: Renal stone disease may be seen as a clinical symptom of an underlying pathological process predisposing to crystallization within the renal tract. Renal stones may be comprised of calcium salts, uric acid, cystine and various other insoluble complexes. Nephrolithiasis may be the manifestation of rare single gene disorders or part of more common idiopathic renal stone-forming diseases. Methods and

John A. Sayer

2011-01-01

388

Seasonal infectious disease epidemiology  

Microsoft Academic Search

formally examined. This paper examines the causes and consequences of seasonality, and in so doing derives several new results concerning vaccination strategy and the interpretation of disease outbreak data. It begins with a brief review of published scientific studies in support of different causes of seasonality in infectious diseases of humans, identifying four principal mechanisms and their association with different

Nicholas C. Grassly; Christophe Fraser

2006-01-01

389

Liver disease in pregnancy  

PubMed Central

Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, Wilson disease, and viral hepatitis may also be seen in pregnancy. Management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy. PMID:19248187

Lee, Noel M; Brady, Carla W

2009-01-01

390

Diseases Caused by Viruses  

Technology Transfer Automated Retrieval System (TEKTRAN)

The symptoms, causal agents, epidemiology and management of important virus diseases in chickpea and lentil crops were reviewed in depth. The virus diseases include.Alflafa mosaic virus, Cucumber mosaiv virus, Faba bean necrotic yellows virus, Pea enation mosaic virus, Pea seed-borne mosaci virus,...

391

Anthocyanins and heart disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Anthocyanins are red, blue, and purple pigments distributed throughout nature, and in our diet. One potential health benefit of dietary anthocyanins is protection against cardiovascular disease (CVD). Evidence for beneficial effects of anthocyanins with respect to heart disease comes from epidemio...

392

PREVENTING DISEASES AND INFECTIONS  

NSDL National Science Digital Library

DESK Standard: Determine how communicable diseases are spread. . DATES: You can begin this activity on January 8. You should complete it by January 12. OBJECTIVE: Everyone wants to feel healthy because being sick is a drag! We have been discussing ways to prevent the spread of infections and diseases during class. There are many ...

Mr. Hughes

2006-02-19

393

Raspberry Mosaic Disease Complex  

Technology Transfer Automated Retrieval System (TEKTRAN)

Raspberry mosaic disease (RMD) is an overarching term used to describe a range of diseases caused by various combinations of different viruses that are each transmitted by aphids. In the scientific literature RMD has been given various alternative names, including red raspberry mosaic, type b mosaic...

394

Neoplastic Diseases: Introduction  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neoplastic diseases of poultry comprise a variety of related and unrelated conditions possessing a single common denominator: neoplastic character. This group of diseases is divided into two main categories, depending on whether the etiologic agent is known. In addition to causing economic loss from...

395

Diagnosis using One disease  

E-print Network

Diagnosis using computers #12;One disease Three therapies #12;Clinical Studies In average 75% 55,7% Without developing any new therapies #12;A higher resolution of dividing a disease into subtypes improves addition desirable · A patients metabolism in a bird`s eye view #12;Tissue DNA Chip Expression profile #12

Spang, Rainer

396

Heart Diseases--Prevention  

MedlinePLUS

... you age. You have a greater risk of heart disease if you are a man over age 45 or a woman over age 55. You also are at greater risk if you have a close family member who had heart disease at an early age. Fortunately, there are ...

397

AUTOINFLAMMATORY PUSTULAR NEUTROPHILIC DISEASES  

PubMed Central

SYNOPSIS The inflammatory pustular dermatoses constitute a spectrum of non-infectious conditions ranging from localized involvement to generalized disease with associated acute systemic inflammation and multi-organ involvement. Despite the variability in extent and severity of cutaneous presentation, each of these diseases is characterized by non-infectious neutrophilic intra-epidermal microabscesses. Many share systemic findings including fever, elevated inflammatory markers, inflammatory bowel disease and/or osteoarticular involvement, suggesting potential common pathogenic links (Figure 1). The recent discoveries of several genes responsible for heritable pustular diseases have revealed a distinct link between pustular skin disease and regulation of innate immunity. These genetic advances have led to a deeper exploration of common pathways in pustular skin disease and offer the potential for a new era of biologic therapy which targets these shared pathways. This chapter provides a new categorization of inflammatory pustular dermatoses in the context of recent genetic and biologic insights. We will discuss recently-described monogenic diseases with pustular phenotypes, including deficiency of IL-1 receptor antagonist (DIRA), deficiency of the IL-36 receptor antagonist (DITRA), CARD14-associated pustular psoriasis (CAMPS), and pyogenic arthritis, pyoderma gangrenosum, acne (PAPA). We will then discuss how these new genetic advancements may inform how we view previously described pustular diseases, including pustular psoriasis and its clinical variants, with a focus on historical classification by clinical phenotype. PMID:23827244

Naik, Haley B.; Cowen, Edward W.

2013-01-01

398

Controlling Infectious Diseases.  

ERIC Educational Resources Information Center

Advocates establishing programs to educate the public about the growing threat of communicable diseases and to promote effective strategies. Utilizes recent successes and failures to formulate those strategies. Profiles three recent infectious disease outbreaks that illustrate some of the current problems. Identifies four ways that lawyers can…

Porter, Wm. Lane; Fidler, David P.

1997-01-01

399

Neoplastic Diseases of Poultry  

Technology Transfer Automated Retrieval System (TEKTRAN)

Depending on whether the etiologic agent is known, neoplastic diseases of poultry are divided into two main classes, virus-induced tumors and tumors of unknown etiology. As a group, neoplastic diseases of poultry comprise a variety of related and unrelated conditions with a single common denominator...

400

Ethics in Prion Disease  

PubMed Central

This paper is intended to discuss some of the scientific and ethical issues that are created by increased research efforts towards earlier diagnosis, as well as to treatment of, human prion diseases (and related dementias), including the resulting consequences for individuals, their families, and society. Most patients with prion disease currently are diagnosed when they are about 2/3 of the way through their disease course (Geschwind, Kuo et al. 2010; Paterson, Torres-Chae et al. 2012), when the disease has progressed so far that even treatments that stop the disease process would probably have little benefit. Although there are currently no treatments available for prion diseases, we and others have realized that we must diagnose patients earlier and with greater accuracy so that future treatments have hope of success. As approximately 15% of prion diseases have a autosomal dominant genetic etiology, this further adds to the complexity of ethical issues, particularly regarding when to conduct genetic testing, release of genetic results, and when or if to implement experimental therapies. Human prion diseases are both infectious and transmissible; great care is required to balance the needs of the family and individual with both public health needs and strained hospital budgets. It is essential to proactively examine and address the ethical issues involved, as well as to define and in turn provide best standards of care. PMID:23906487

Bechtel, Kendra; Geschwind, Michael D.

2013-01-01

401

Jakob-Creutzfeldt Disease  

Microsoft Academic Search

Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy. It is characterised pathologically by neuronal loss, spongy changes in the grey matter and an astrocytosis, and clinically by rapidly progressing dementia, pyramidal and extrapyramidal disease with myoclonus and triphasic discharges in the electroencephalogram. This dreaded fatal illness remained mysterious in its cause until Pruisner’s exciting discovery of proteinaceous infectious particles, which

J. M. S. Pearce

2004-01-01

402

Lesch-Nyhan Disease.  

ERIC Educational Resources Information Center

This special edition explores the serious genetic disorder, Lesch-Nyhan Disease (LND), which is characterized by severe dystonia, spasticity, speech impairment, renal disease, varying degrees of cognitive deficit, and, especially, compulsive self-injury. The information provided is based on experience at the Matheny School and Hospital (New…

Barabas, Gabor, Ed.

1993-01-01

403

Inflammation and disease progression  

Microsoft Academic Search

Inflammation is a physiological response to a foreign organism such as bacteria, dust particles, and viruses. Recent studies have enlightened the role of inflammation in the progression of a variety of diseases such as cancer, atherosclerosis, asthma, and psoriasis. This article is a brief overview of the inflammatory processes involved in the progression of these common diseases. Knowledge about these

Sriram Krishnamoorthy; Kenneth V. Honn

2006-01-01

404

[Childhood diseases with exanthema].  

PubMed

- Due to high vaccination coverage, measles and rubella (German measles) are now rarely seen in the Netherlands, which makes recognition of these diseases difficult. - Measles can also occur in people who have been immunized, as a result of vaccination failure. - Swift recognition of measles and rubella is necessary in order to manage them adequately and to prevent spreading of the disease. - Measles, rubella, and erythema infectiosum ('fifth disease') may result in complications during pregnancy. - Measles, rubella, scarlet fever, erythema infectiosum, and roseola ('sixth disease') can be difficult to differentiate. - In the Netherlands, diagnosis of a patient with measles or rubella, or of more than 1 patient with erythema infectiosum within one institution, must be reported to the local health authority within 1 working day. - Exclusion from school or a day-care facility is not required for any if the diseases discussed. PMID:22008158

Opstelten, Wim; Eekhof, Just A H; Knuistingh Neven, Arie

2011-01-01

405

Genetic renal disease.  

PubMed

Many genetic renal disease now have specific genetic definitions, allowing prognostication. Several glomerular basement membrane defects include Alport's syndrome and benign familial hematurias. Genetic tubular or interstitial structural defects likely include familial juvenile nephronophthisis, as well as the polycystic diseases. Hereditary metabolic diseases can result in storage processes and circulating lipid disorders, which result in progressive glomerular sclerosis. Hereditary metabolic errors result in products causing obstruction and interstitial damage. Other hereditary disorders cause hemodynamic process that result in renal damage. The vascular structural defects of Marfan syndrome, Alagille syndrome, neurofibromatosis, and Cockayne's syndrome can secondarily result in renal vascular destruction. An awareness of these hereditary disease pathways to renal disease is essential to primary care pediatrics. PMID:9608896

Saborio, P; Scheinman, J

1998-04-01

406

Hyperosmia in Lyme disease.  

PubMed

Neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. While it is known that in some cases of asceptic meningitis patients may develop hyperosmia, the association between hyperosmia and Lyme disease has not previously been studied. Objective To carry out the first systematic study to ascertain whether hyperosmia is also a feature of Lyme disease. Method A questionnaire regarding abnormal sensory sensitivity in respect of the sense of smell was administered to 16 serologically positive Lyme disease patients and to 18 control subjects. Results The two groups were matched in respect of age, sex and body mass. None of the 34 subjects was suffering from migraine. Eight (50%) of the Lyme patients and none (0%) of the controls suffered from hyperosmia (p=0.0007). Conclusion This first systematic controlled study showed that Lyme disease is associated with hyperosmia. PMID:25098475

Puri, Basant K; Monro, Jean A; Julu, Peter O O; Kingston, Michele C; Shah, Mussadiq

2014-08-01

407

[Adult onset Still's disease].  

PubMed

Adult onset Still's disease is a rare, febrile, multisystem rheumatic disease with unknown etiology, which runs an intermittent course and can either go into remission after months to years or progress to a chronic course with substantial joint destruction. The prevalence of this disease has been increasing in the last decade presumably caused by better diagnostic tools but also by a higher awareness among physicians taking care of patients with "fever of unknown origin". This review is intended to augment this trend, since research on the role of proinflammatory cytokines in this disease has led to an improved diagnostic and therapeutic repertoire over the last few years. Ferritin and interleukin-18 serum levels are valuable diagnostic parameters and blockade of interleukin-1, interleukin-6, and tumor-necrosis-factor alpha can effectively control the inflammatory activity of this disease in most cases and also in life-threatening conditions. PMID:18696089

Manger, B

2008-09-01

408

Epigenetics and Autoimmune Diseases  

PubMed Central

Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanisms are a window to understanding the possible mechanisms involved in the pathogenesis of complex diseases such as autoimmune diseases. It is noteworthy that autoimmune diseases do not have the same epidemiology, pathology, or symptoms but do have a common origin that can be explained by the sharing of immunogenetic mechanisms. Currently, epigenetic research is looking for disruption in one or more epigenetic mechanisms to provide new insights into autoimmune diseases. The identification of cell-specific targets of epigenetic deregulation will serve us as clinical markers for diagnosis, disease progression, and therapy approaches. PMID:22536485

Quintero-Ronderos, Paula; Montoya-Ortiz, Gladis

2012-01-01

409

Diseases of echinoderms  

NASA Astrophysics Data System (ADS)

Diseases of echinoderms are poorly documented. Most reports concern biotic diseases caused by animal agents. While parasites on echinoderms have been described in increasing numbers of papers for more than one century, the host-parasite relationship and the effects of parasitism on echinoderm life-cycles were rarely considered. The parasitic fauna differs markedly according to the echinoderm group concerned, depending on various factors such as feeding-habits or symbiogenesis. Microorganismic diseases undoubtedly occur in echinoderms but they were not investigated until recently. Microorganisms have frequently been assumed to act as agents causing mass mortalities. As for stress-caused diseases, the only — and very preliminary — data available concern almost exclusively those induced by pollution. Since echinoderms are major components of benthic ecosystems, echinoderm diseases may be expected to exert prominent ecological effects.

Jangoux, M.

1984-03-01

410

Diseases of salamanders  

USGS Publications Warehouse

Few diseases are reported in salamanders. Two notable exceptions are infections by Ranavirus and Ichthyophonus. Except for mortality events associated with ranaviruses in tiger salamanders (Ambystoma tigrinum) and spotted salamanders (A. maculatum), dieoffs of salamanders are rarely detected or reported. Diseases presented in this chapter are those encountered in free-living salamanders of the United States and Canada. A few additional diseases that are occasionally seen in captive and zoo animals have been reviewed by Green (2001). This chapter on Diseases of Salamanders will address five common infectious diseases of free-living larval and adult salamanders: Ranavirus (iridovims) infection Chytrid fungal infection Ichthyophoniasis Clinostomum metacercaria Chiggers Many helminthic parasites infect salamanders, but with few exceptions, these infections are unlikely to cause illness (morbidity) or death (mortality). Readers are referred to parasitology texts for a review of protozoan, helminthic and ectoparasitic organisms of amphibians (Flynn, 1973; Poynton and Whitaker, 2001).

Converse, K.A.; Green, D.E.

2005-01-01

411

The association of periodontal disease, diabetes and cardiovascular disease  

Microsoft Academic Search

Background: Evidence for a link between periodontal disease and several systemic diseases is growing rapidly. Current evidence suggests that periodontitis is associated with an increased likelihood of coronary heart disease and diabetesScope: A consensus group reviewed published data on the contributory role of periodontal disease to overall health. Particular consideration was given to a role for periodontal disease in cardiovascular

Roger Gadsby

2008-01-01

412

The differential disease regulome  

PubMed Central

Background Transcription factors in disease-relevant pathways represent potential drug targets, by impacting a distinct set of pathways that may be modulated through gene regulation. The influence of transcription factors is typically studied on a per disease basis, and no current resources provide a global overview of the relations between transcription factors and disease. Furthermore, existing pipelines for related large-scale analysis are tailored for particular sources of input data, and there is a need for generic methodology for integrating complementary sources of genomic information. Results We here present a large-scale analysis of multiple diseases versus multiple transcription factors, with a global map of over-and under-representation of 446 transcription factors in 1010 diseases. This map, referred to as the differential disease regulome, provides a first global statistical overview of the complex interrelationships between diseases, genes and controlling elements. The map is visualized using the Google map engine, due to its very large size, and provides a range of detailed information in a dynamic presentation format. The analysis is achieved through a novel methodology that performs a pairwise, genome-wide comparison on the cartesian product of two distinct sets of annotation tracks, e.g. all combinations of one disease and one TF. The methodology was also used to extend with maps using alternative data sets related to transcription and disease, as well as data sets related to Gene Ontology classification and histone modifications. We provide a web-based interface that allows users to generate other custom maps, which could be based on precisely specified subsets of transcription factors and diseases, or, in general, on any categorical genome annotation tracks as they are improved or become available. Conclusion We have created a first resource that provides a global overview of the complex relations between transcription factors and disease. As the accuracy of the disease regulome depends mainly on the quality of the input data, forthcoming ChIP-seq based binding data for many TFs will provide improved maps. We further believe our approach to genome analysis could allow an advance from the current typical situation of one-time integrative efforts to reproducible and upgradable integrative analysis. The differential disease regulome and its associated methodology is available at http://hyperbrowser.uio.no. PMID:21736759

2011-01-01

413

Some Important Diseases of Tree Fruits - Diseases of Vegetable Crops - Diseases of Grapes - Diseases of Tree Nuts.  

ERIC Educational Resources Information Center

This agriculture extension service publication from Pennsylvania State University consists of four sections on plant disease recognition and control. The titles of these four sections are: (1) Some Important Diseases of Tree Fruits; (2) Diseases of Vegetable Crops; (3) Diseases of Crops; and (4) Diseases of Tree Nuts. The first section discusses…

Petersen, Donald H.; And Others

414

Disease management strategies for wildlife  

Microsoft Academic Search

Summary Three basic forms of management strategies exist for wildlife disease, as follows: prevention of introduction of disease, control of existing disease or eradication. Management may be directed at the disease agent, host population, habitat or be focused on human activities. Disease agents may be dealt with in the environment through disinfection or in the host through treatment. Disinfection and

G. Wobeser

2002-01-01

415

End Stage Renal Disease (ESRD)  

MedlinePLUS

Kidney Disease Chronic Kidney Disease Kidney-Friendly Diet & Foods for CKD Polycystic Kidney Disease Kidney Failure End Stage Renal Disease Complication: Anemia Complication: Bone Disease Kidney Failure Treatment Kidney Problems Blood in Your Urine (Hematuria) Protein in Urine Kidney Stones ...

416

Domoic acid epileptic disease.  

PubMed

Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic epileptic syndrome in California sea lions through investigation of a series of domoic acid poisoning cases between 1998 and 2006. The sea lion study provided a breadth of insight into clinical presentations, unusual behaviors, brain pathology, and epidemiology. A rat model that replicates key observations of the chronic epileptic syndrome in sea lions has been applied to identify the progression of the epileptic disease state, its relationship to behavioral manifestations, and to define the neural systems involved in these behavioral disorders. Here, we present the concept of domoic acid epileptic disease as a delayed manifestation of domoic acid poisoning and review the state of knowledge for this disease state in affected humans and sea lions. We discuss causative mechanisms and neural underpinnings of disease maturation revealed by the rat model to present the concept for olfactory origin of an epileptic disease; triggered in dendodendritic synapases of the olfactory bulb and maturing in the olfactory cortex. We conclude with updated information on populations at risk, medical diagnosis, treatment, and prognosis. PMID:24663110

Ramsdell, John S; Gulland, Frances M

2014-03-01

417

Inherited renal diseases.  

PubMed

Genetic disorders of the kidney include cystic diseases, metabolic diseases and immune glomerulonephritis. Cystic diseases include autosomal dominant and recessive polycystic kidney disease (ADPKD, ARPKD, respectively). Neonates with enlarged, cystic kidneys should be evaluated for PKD. Patients with ADPKD have cysts and renal enlargement. Most patients present with hypertension, hematuria or flank pain; the most common extrarenal manifestation is polycystic liver disease. Oligohydramnios, bilaterally enlarged kidneys and decreased urine are featured in utero in ARPKD. Medullary sponge kidney is uncommon and features nephrocalcinosis, recurrent calcium stones and a history of polyuria/nocturia and/or urinary tract infections. Alport syndrome (AS) is an inherited disease of the glomerular basement membrane that is usually inherited as an X-linked dominant trait. Most patients with AS present in the first two decades of life with persistent microscopic or gross hematuria. Later, proteinuria is seen and its presence portends disease progression. Other findings may include sensorineural hearing loss and ocular abnormalities. There are various inherited tubulopathies, including Bartter syndrome, a group of renal tubular disorders that consist of two phenotypes with four genotypes. Patients usually present early in life with salt wasting, hypokalemia and metabolic alkalosis. Other features, depending on genotype, may include polyhydramnios and premature birth. Gitelman syndrome is also a salt-losing tubulopathy characterized by hypokalemic alkalosis. The majority of patients with Gitelman syndrome present during adolescence or early adulthood. PMID:25088262

Leung, Jocelyn C

2014-01-01

418

Somatic mosaicism and disease.  

PubMed

The large number of cell divisions required to make a human body inevitably leads to the accumulation of somatic mutations. Such mutations cause individuals to be somatic mosaics. Recent advances in genomic technology now allow measurement of somatic diversity. Initial studies confirmed the expected high levels of somatic mutations within individuals. Going forward, the big questions concern the degree to which those somatic mutations influence disease. Theory predicts that the frequency of mutant cells should vary greatly between individuals. Such somatic mutational variability between individuals could explain much of the diversity in the risk of disease. But how variable is mosaicism between individuals in reality? What is the relation between the fraction of cells carrying a predisposing mutation and the risk of disease? What kinds of heritable somatic change lead to disease besides classical DNA mutations? What molecular processes connect a predisposing somatic change to disease? We know that predisposing somatic mutations strongly influence the onset of cancer. Likewise, neurodegenerative diseases may often begin from somatically mutated cells. If so, both neurodegeneration and cancer may be diseases of later life for which much of the risk may be set by early life somatic mutations. PMID:24937287

Frank, Steven A

2014-06-16

419

[Autoinflammatory diseases in childhood].  

PubMed

Autoinflammatory diseases are a group of monogenic inflammatory diseases with an early onset in childhood. Previously these diseases were summarized as"periodic fever syndromes." Included in this spectrum are familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated disease. They are characterized by periodic or recurrent episodes of systemic inflammation causing fever, accompanied by rash, serositis, lymphadenopathy, arthritis, and other clinical manifestations. The other large group of autoinflammatory diseases consists of the cryopyrin-associated periodic syndromes, which include the cryopyrinopathies. The mildest form is familial cold-associated syndrome, a more severe form is Muckle-Wells syndrome, and the most severe is neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous and articular syndrome. These are characterized by chronic or recurrent systemic inflammation associated with various clinical presentations, including urticaria-like rash, arthritis, sensorineural deafness, and central nervous system and bone involvement. In our review we focus on the clinical presentation of these diseases. PMID:19841924

Foeldvari, I; Kümmerle-Deschner, J

2009-11-01

420

Dynamics of Interacting Diseases  

NASA Astrophysics Data System (ADS)

Current modeling of infectious diseases allows for the study of complex and realistic scenarios that go from the population to the individual level of description. However, most epidemic models assume that the spreading process takes place on a single level (be it a single population, a metapopulation system, or a network of contacts). In particular, interdependent contagion phenomena can be addressed only if we go beyond the scheme-one pathogen-one network. In this paper, we propose a framework that allows us to describe the spreading dynamics of two concurrent diseases. Specifically, we characterize analytically the epidemic thresholds of the two diseases for different scenarios and compute the temporal evolution characterizing the unfolding dynamics. Results show that there are regions of the parameter space in which the onset of a disease's outbreak is conditioned to the prevalence levels of the other disease. Moreover, we show, for the susceptible-infected-susceptible scheme, that under certain circumstances, finite and not vanishing epidemic thresholds are found even at the limit for scale-free networks. For the susceptible-infected-removed scenario, the phenomenology is richer and additional interdependencies show up. We also find that the secondary thresholds for the susceptible-infected-susceptible and susceptible-infected-removed models are different, which results directly from the interaction between both diseases. Our work thus solves an important problem and paves the way toward a more comprehensive description of the dynamics of interacting diseases.

Sanz, Joaquín; Xia, Cheng-Yi; Meloni, Sandro; Moreno, Yamir

2014-10-01

421

Indian genetic disease database  

PubMed Central

Indians, representing about one-sixth of the world population, consist of several thousands of endogamous groups with strong potential for excess of recessive diseases. However, no database is available on Indian population with comprehensive information on the diseases common in the country. To address this issue, we present Indian Genetic Disease Database (IGDD) release 1.0 (http://www.igdd.iicb.res.in)—an integrated and curated repository of growing number of mutation data on common genetic diseases afflicting the Indian populations. Currently the database covers 52 diseases with information on 5760 individuals carrying the mutant alleles of causal genes. Information on locus heterogeneity, type of mutation, clinical and biochemical data, geographical location and common mutations are furnished based on published literature. The database is currently designed to work best with Internet Explorer 8 (optimal resolution 1440?×?900) and it can be searched based on disease of interest, causal gene, type of mutation and geographical location of the patients or carriers. Provisions have been made for deposition of new data and logistics for regular updation of the database. The IGDD web portal, planned to be made freely available, contains user-friendly interfaces and is expected to be highly useful to the geneticists, clinicians, biologists and patient support groups of various genetic diseases. PMID:21037256

Pradhan, Sanchari; Sengupta, Mainak; Dutta, Anirban; Bhattacharyya, Kausik; Bag, Sumit K.; Dutta, Chitra; Ray, Kunal

2011-01-01

422

[Erdheim-Chester disease].  

PubMed

Erdheim-Chester disease is a rare and orphan disease. Despite having been overlooked previously, numerous new cases have been diagnosed more recently. The number of Erdheim-Chester disease cases reported has increased substantially: more than 300 new cases have been published in the past 10 years. This situation is mainly a result of the generally better awareness among pathologists, radiologists, and clinicians of various aspects of this rare disease. The field has been particularly active in the last few years, with evidence of the efficacy of interferon-?, the description of a systemic pro-inflammatory cytokine signature, and most recently, reports of the dramatic efficacy of BRAF inhibition in severe, BRAF(V600E) mutation-associated cases of Erdheim-Chester disease. Also, BRAF mutations have been found in more than half of the patients with Erdheim-Chester disease who were tested. Detailed elucidation of the pathogenesis of the disease is likely to lead to the development of better targeted and more effective therapies. PMID:24878295

Haroche, J; Cohen-Aubart, F; Arnaud, L; Hervier, B; Charlotte, F; Drier, A; Gorochov, G; Grenier, P A; Cluzel, P; Maksud, P; Emile, J-F; Amoura, Z

2014-11-01

423

Genetic kidney diseases  

PubMed Central

Knowledge of the primary cause of a disease is essential for understanding its mechanisms and for adequate classification, prognosis, and treatment. Recently, the etiologies of many kidney diseases have been revealed as single-gene defects. This is exemplified by steroid-resistant nephrotic syndrome, which is caused by podocin mutations in ~25% of childhood and ~15% of adult cases. Knowledge of a disease-causing mutation in a single-gene disorder represents one of the most robust diagnostic examples of “personalized medicine”, because the mutation conveys an almost 100% risk of developing the disease by a certain age. Whereas single-gene diseases are rare disorders, polygenic “risk alleles” are found in common adult-onset diseases. This review will discuss prominent renal single-gene kidney disorders and polygenic risk alleles of common disorders. We delineate how emerging techniques of total exome capture and large-scale sequencing will facilitate molecular genetic diagnosis, prognosis and specific therapy and lead to a better understanding of disease mechanisms, thus enabling development of new targeted drugs. PMID:20382325

Hildebrandt, Friedhelm

2010-01-01

424

Chronic granulomatous disease: why an inflammatory disease?  

PubMed Central

Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects. PMID:25296353

Roxo-Junior, P.; Simăo, H.M.L.

2014-01-01

425

Peyronie's Disease: Still a Surgical Disease.  

PubMed

Peyronie's Disease (PD) remains a challenging and clinically significant morbid condition. Since its first description by François Gigot de la Peyronie, much of the treatment for PD remains nonstandardized. PD is characterized by the formation of fibrous plaques at the level of the tunica albuginea. Clinical manifestations include morphologic changes, such as curvatures and hourglass deformities. Here, we review the common surgical techniques for the management of patients with PD. PMID:22956943

Martinez, Daniel; Ercole, Cesar E; Hakky, Tariq S; Kramer, Andrew; Carrion, Rafael

2012-01-01

426

Degenerative joint disease: cartilage or vascular disease?  

Microsoft Academic Search

The aetiology of degenerative joint diseases is multifactorial, but one main cause is overloading (mechanical stress). While\\u000a until recently it was well accepted that this represented primarily a disorder of cartilage with reactive subchondral changes,\\u000a there is now some evidence that it might be primarily a subchondral problem with secondary changes in the articular cartilage.\\u000a Early subchondral changes include redistribution

H. Imhof; M. Breitenseher; F. Kainberger; S. Trattnig

1997-01-01

427

Rheumatic Diseases and Malignancies  

PubMed Central

ABSTRACT There are many studies which demonstrate a higher risk for malignancy in patients with rheumatic diseases. There have been a number of possible explanations for the differences in the risk of certain malignancies in patients with rheumatic disease, compared with general population, but a clear mechanism is difficult to identify. Rheumatoid syndromes may be associated with malignancy as paraneoplastic conditions, which can antedate the neoplasm diagnosis. On the other hand, autoimmune rheumatic diseases have a higher risk of malignancy by themselves or because of the immunosuppressant treatments. PMID:23482881

BOJINCA, Violeta; JANTA, Iustina

2012-01-01

428

Localized renal cystic disease  

PubMed Central

Localized renal cystic disease (LRCD) is a rare benign non-hereditary, non-progressive condition which must be differentiated from other renal cystic diseases. Familiarity with this condition and its characteristic imaging features avoids unnecessary surgical intervention. We report a case of LRCD in a 40-year-old male who presented with left loin pain. Computed tomography demonstrated a cluster of simple cysts in the lower pole of the left kidney with normal right kidney and other organs. Diagnosis of LRCD was made on typical imaging characteristics and absence of family history of cystic renal disease.

Narayanan, Ramakrishna; Shankar, Balasubramanyam; Kulkarni, Chaitanya D.

2015-01-01

429

Alzheimer's Disease International  

NSDL National Science Digital Library

Alzheimer's Disease International (ADI) is an umbrella group of 66 Alzheimer associations throughout the world. The ADI website provides contact information for numerous Alzheimer associations located in such nations as Brazil, Iceland, Singapore, the United Kingdom, and many more. The site also provides dates and contacts for numerous upcoming conferences and other events, as well as information regarding the 2004 ADI conference in Kyoto, Japan. Site visitors will also find basic information about Alzheimer's disease and other forms of dementia. Notably, this site links to Alzheimer's disease information in many languages including Arabic, Hebrew, Hindi, and Spanish--just to name a few.

430

Bone hydatid disease  

PubMed Central

Bone hydatid disease lacks a typical clinical appearance and image characteristics on x ray or CT are similar to those of tuberculosis, metastases and giant cell tumour or bone cysts. However, MRI does show distinctive diagnostic features of bone hydatid disease, especially in the spine. Until recently, treatment of osseous hydatid disease has been entirely surgical. Effective chemotherapy using benzimidazoles, particularly mebendazole, albendazole and combination treatments, has now been achieved in experimental studies and clinical practice. However, most of these drugs are still in the experimental stage or are in the early stages of clinical use. PMID:17675547

Song, X H; Ding, L W

2007-01-01

431

Chronic Wasting Disease  

USGS Publications Warehouse

Chronic wasting disease (CWD) is an always-fatal, neurological illness occurring in North American cervids (members of the deer family), including white-tailed deer, mule deer, elk and moose. Since its discovery in 1967, CWD has spread geographically and increased in prevalence locally. CWD is contagious; it can be transmitted freely within and among free-ranging populations. It is likely that diseased animals can transmit CWD to healthy animals long before they become clinically ill. Managing CWD in free-ranging populations is extremely difficult, therefore preventative measures designed to reduce the chance for disease spread are critically important.

Richards, Bryan

2007-01-01

432

Parkinson's disease: recent advances.  

PubMed

While a curative treatment for Parkinson's disease remains elusive, our understanding of disease mechanisms as well as preclinical and pre-motor early manifestations has improved greatly over the past years. An agent with proven disease modifying properties has not yet been identified but symptomatic treatment options for affected patients have improved. For patients with motor complications, this includes invasive approaches such as deep brain stimulation and continuous device-aided drug delivery. The many facets of non-motor problems patients are faced with have finally been fully recognized and have become the target of treatment trials, as have been non-pharmacological approaches. PMID:24687891

Katzenschlager, Regina

2014-05-01

433

Adventures in Infectious Diseases  

SciTech Connect

Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

Fisher-Hoch, Susan [University of Texas School of Public Health

2011-11-01

434

Adventures in Infectious Diseases  

ScienceCinema

Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

Fisher-Hoch, Susan [University of Texas School of Public Health

2014-06-25

435

Zygomycetes in Human Disease  

PubMed Central

The Zygomycetes represent relatively uncommon isolates in the clinical laboratory, reflecting either environmental contaminants or, less commonly, a clinical disease called zygomycosis. There are two orders of Zygomycetes containing organisms that cause human disease, the Mucorales and the Entomophthorales. The majority of human illness is caused by the Mucorales. While disease is most commonly linked to Rhizopus spp., other organisms are also associated with human infection, including Mucor, Rhizomucor, Absidia, Apophysomyces, Saksenaea, Cunninghamella, Cokeromyces, and Syncephalastrum spp. Although Mortierella spp. do cause disease in animals, there is no longer sufficient evidence to suggest that they are true human pathogens. The spores from these molds are transmitted by inhalation, via a variety of percutaneous routes, or by ingestion of spores. Human zygomycosis caused by the Mucorales generally occurs in immunocompromised hosts as opportunistic infections. Host risk factors include diabetes mellitus, neutropenia, sustained immunosuppressive therapy, chronic prednisone use, iron chelation therapy, broad-spectrum antibiotic use, severe malnutrition, and primary breakdown in the integrity of the cutaneous barrier such as trauma, surgical wounds, needle sticks, or burns. Zygomycosis occurs only rarely in immunocompetent hosts. The disease manifestations reflect the mode of transmission, with rhinocerebral and pulmonary diseases being the most common manifestations. Cutaneous, gastrointestinal, and allergic diseases are also seen. The Mucorales are associated with angioinvasive disease, often leading to thrombosis, infarction of involved tissues, and tissue destruction mediated by a number of fungal proteases, lipases, and mycotoxins. If the diagnosis is not made early, dissemination often occurs. Therapy, if it is to be effective, must be started early and requires combinations of antifungal drugs, surgical intervention, and reversal of the underlying risk factors. The Entomophthorales are closely related to the Mucorales on the basis of sexual growth by production of zygospores and by the production of coenocytic hyphae. Despite these similarities, the Entomophthorales and Mucorales have dramatically different gross morphologies, asexual reproductive characteristics, and disease manifestations. In comparison to the floccose aerial mycelium of the Mucorales, the Entomophthorales produce a compact, glabrous mycelium. The asexually produced spores of the Entomophthorales may be passively released or actively expelled into the environment. Human disease with these organisms occurs predominantly in tropical regions, with transmission occurring by implantation of spores via minor trauma such as insect bites or by inhalation of spores into the sinuses. Conidiobolus typically infects mucocutaneous sites to produce sinusitis disease, while Basidiobolus infections occur as subcutaneous mycosis of the trunk and extremities. The Entomophthorales are true pathogens, infecting primarily immunocompetent hosts. They generally do not invade blood vessels and rarely disseminate. Occasional cases of disseminated and angioinvasive disease have recently been described, primarily in immunocompromised patients, suggesting a possible emerging role for this organism as an opportunist. PMID:10756000

Ribes, Julie A.; Vanover-Sams, Carolyn L.; Baker, Doris J.

2000-01-01

436

Height and heart disease.  

PubMed

Height has a relationship with a number of medical conditions, including heart disease. Atrial fibrillation has been observed to be more common in taller individuals. Marfan syndrome, with its high prevalence of mitral valve disease and abnormalities of the aorta, is associated with increased height. Mitral valve prolapse in patients without Marfan syndrome may be more common in taller people. Conversely, congestive heart failure, coronary artery disease, and possibly aortic valve calcification are less prevalent with increasing height. The relationship between height and health will be of increasing importance as the population grows taller. PMID:25051127

Rosenbush, Stuart W; Parker, Jeremy M

2014-01-01

437

[Emerging parasitic diseases].  

PubMed

Travels, migration and circulation of goods facilitate the emergence of new infectious diseases often unrecognized outside endemic areas. Most of emerging infections are of viral origin. Muscular Sarcocystis infection, an acute illness acquired during short trips to Malaysia, and Chagas disease, a chronic illness with long incubation period found among Latin American migrants, are two very different examples of emerging parasitic diseases. The former requires a preventive approach for travelers going to Malaysia and must be brought forth when they return with fever, myalgia and eosinophilia, while the latter requires a proactive attitude to screen Latin American migrant populations that may face difficulties in accessing care. PMID:24908745

Weibel Galluzzo, C; Wagner, N; Michel, Y; Jackson, Y; Chappuis, F

2014-05-01

438

TRP Channels in Disease  

NSDL National Science Digital Library

The mammalian TRP (transient receptor potential) family consists of six main subfamilies that include 28 ion channels that function as cellular sensors of various phenomena, including changes in temperature, osmolarity, pH, membrane stretch, and various second messenger pathways. All of the TRP channels are permeable to monovalent cations, and most are also permeable to calcium ions. There are strong indications that TRP channels are involved in many diseases. This review highlights some TRP "suspects" for which a role in disease can be anticipated. An understanding of the genetics of disease may lead to the development of targeted new therapies.

Bernd Nilius (Campus Gasthuisberg Katholieke Universiteit Leuven B; Department of Physiology REV)

2005-08-02

439

Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease   

E-print Network

Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

McAllister, David Anthony

2011-07-05

440

CTEP Simplified Disease Classification Overview  

Cancer.gov

CTEP Simplified Disease Classification Overview The CTEP Simplified Disease Classification (CTEP SDC) v1.0 is a restructured, more intuitive classification of diseases, designed to meet the needs of CTEP while still allowing reporting based on the

441

A Manual of Poultry Diseases.  

E-print Network

......................................... Treatment of Disease Outbreaks 10 .............................. Vaccination to Prevent Poultry Diseases 10 What Vaccines Are ................................................................... 10 Dangers of Vaccination... ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases for Which Vaccines Are Available ........................ 11 .................................................... Administration of Vaccines 11 ................ A...

Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

1971-01-01

442

Celiac Disease and Thyroid Conditions  

MedlinePLUS

... follow-up with the doctor? With the dietitian? Celiac Disease and Thyroid Disease: The Connection Researchers have found ... is available at www.GLUTEN.net. Advances in celiac disease are fast-paced. If this document is more ...

443

Warning Signs of Lung Disease  

MedlinePLUS

... Lungs Warning Signs of Lung Disease Top Stories Lung HelpLine Questions about your lung health? Need help ... Warning Signs of Lung Disease Warning Signs of Lung Disease WARNING SIGNS If you have any of ...

444

Interstitial lung disease - adults - discharge  

MedlinePLUS

... your breathing problems that are caused by interstitial lung disease. This disease scars your lungs, which makes it ... Raghu G. Interstitial lung disease. In: Goldman L, Schafer AI. ... ed. Philadelphia, PA: Elsevier Saunders; 2011: chap 92. Selman M, ...

445

Respiratory Disease and the Environment  

MedlinePLUS

... www.niehs.nih.gov Respiratory Disease and the Environment Respiratory diseases such as asthma, pneumonia, influenza and ... than $113 million to support research on the environment and respiratory disease in 2007. Stepping into the ...

446

A Manual of Poultry Diseases.  

E-print Network

............................................................. 10 ............ ......................... Treatment of Disease Outbreaks .. 10 Vaccination to Prevent Poultry Diseases ............ ... ............ 10 ....................... What Vaccines Are .............. .............................. 10... Dangers of Vaccination ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11...

Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

1965-01-01

447

What Causes Coronary Microvascular Disease?  

MedlinePLUS

... Living With Clinical Trials Links Related Topics Angina Atherosclerosis Coronary Heart Disease Coronary Heart Disease Risk Factors ... Microvascular Disease? The same risk factors that cause atherosclerosis (ATH-er-o-skler-O-sis) may cause ...

448

Kidney Disease: A Silent Problem  

MedlinePLUS

... hormones that your body needs to stay healthy. Kidney Disease Kidney disease can sometimes develop very quickly, ... disease, arthritis , and nerve damage. Medicine And Your Kidneys Older people often take lots of medicines. Kidneys ...

449

Animals: Disease Risks for People  

MedlinePLUS

... Care Animal Welfare Veterinary Careers Public Health Disease Risks for People at Dog Social Events People attending dog social events can be at risk of zoonotic diseases, which are diseases that spread ...

450

Liver Disease and Adult Vaccination  

MedlinePLUS

... Vaccination Home Recommended Vaccines for Adults Share Compartir Liver Disease and Adult Vaccination Vaccines are especially critical for people with health conditions such as liver disease. If you have chronic liver disease, talk ...

451

The prion diseases of animals  

Technology Transfer Automated Retrieval System (TEKTRAN)

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that affect several species of animals and include bovine spongiform encephalopathy (BSE), scrapie in sheep and goats, chronic wasting disease (CWD) in cervids, and transmissible mink encephalopat...

452

Lyme Disease: Fact or Fiction?  

MedlinePLUS

... Emerging and Zoonotic Infectious Diseases (NCEZID) Division of Vector-Borne Diseases (DVBD) Home A-Z Index Policies Using this Site Link to Us Contact CDC Centers for Disease Control and Prevention 1600 Clifton Road Atlanta, GA 30329- ...

453

What Is a Neuromuscular Disease?  

MedlinePLUS

... neuromuscular disease, see Neuromuscular Disease Descriptions . Printer-friendly version Publications Magazines Advertise Guidebooks Daily Living "Facts About" Booklets MDA Programs Frequently Asked Questions A Teacher's Guide to Neuromuscular Disease An ...

454

Living with Carotid Artery Disease  

MedlinePLUS

... from the NHLBI on Twitter. Living With Carotid Artery Disease If you have carotid artery disease, you can take steps to manage the ... treatment plan, and getting ongoing care. Having carotid artery disease raises your risk of having a stroke . ...

455

JAMA Patient Page: Chagas Disease  

MedlinePLUS

... of the American Medical Association JAMA PATIENT PAGE Chagas Disease C hagas disease, or American trypanosomiasis, is ... or an organ transplanted from an infected donor. Chagas disease occurs mainly in Latin America, where an ...

456

Diabetes, Heart Disease, and Stroke  

MedlinePLUS

... and Titles : Diabetes, Heart Disease, and Stroke Diabetes, Heart Disease, and Stroke On this page: What is ... stroke. [Top] What is the connection between diabetes, heart disease, and stroke? If you have diabetes, you ...

457

Examples of Neglected Tropical Diseases  

MedlinePLUS

... disease can be contracted by walking barefoot on soil contaminated by feces. Symptoms of the disease include ... irreversible blindness. Trichuriasis (whipworm disease) : Contracted by ingesting soil or vegetables contaminated with feces containing whipworm eggs, ...

458

Paget Disease of the Breast  

MedlinePLUS

... involve Paget disease of the breast. The average age at diagnosis is 57 years, but the disease has been found in adolescents and in people in their late 80s ( 2 , 3 ). What causes Paget disease of ...

459

Living with Diabetic Heart Disease  

MedlinePLUS

... from the NHLBI on Twitter. Living With Diabetic Heart Disease Diabetic heart disease (DHD) increases the likelihood of earlier and more ... also tend to have less success from certain heart disease treatments, such as coronary artery bypass grafting and ...

460

Fifth Disease (Parvovirus B19)  

MedlinePLUS

... Disease (Parvovirus B19) Health Issues Listen Fifth Disease (Parvovirus B19) Article Body Fifth disease, also called erythema ... cheeks. It is caused by a virus called parvovirus B19 and can be spread from one person ...

461

Celiac Disease Tests  

MedlinePLUS

... website will be limited. Search Help? Celiac Disease Antibody Tests Share this page: Was this page helpful? Also known as: Anti-tissue Transglutaminase Antibody; tTG; tTGA; Endomysial Antibody; EMA; DGP; ARA; Total ...

462

Lesson 30: Diseases [magonjwa  

E-print Network

(noun)] kifafa [epilepsy] kifuakikuu [tuberculosis] kikohozi [cough] kipindupindu [cholera] tumbo la [constipation] maradhi [diseases] najisi [rape] zimia; zirai [fainting] kiungulia [heartburn] kifaduro [whooping cough] kiharusi [polio] baridi yabisi [rheumatism] kuumika perema kupooza matege ngiri chango lukemia

463

Scabies: Disease Symptoms  

MedlinePLUS

... message, please visit this page: About CDC.gov . Parasites - Scabies Parasites Home Share Compartir Disease When a person is ... reaction) to the proteins and feces of the parasite. Severe itching (pruritus), especially at night, is the ...

464

Disease and Evolution.  

ERIC Educational Resources Information Center

Discusses disease and genetic disorders as evolutionary mechanisms. Emphasizes the archeological evidence from past human populations and societies, mentioning albinism, scurvy, sleeping sickness, bone conditions, various host-parasite relationships, rickets, sickle-cell anemia, diabetes, and influenza. (CS)

Wells, Calvin

1978-01-01

465

Diet and Chronic Disease  

Technology Transfer Automated Retrieval System (TEKTRAN)

Factors that improve insulin sensitivity usually lead to improvements in risk factors associated with the metabolic syndrome, diabetes and cardiovascular diseases. Naturally occurring bioactive compounds that have been shown to improve insulin sensitivity include chromium and polyphenols found in c...

466

Hemoglobin C disease  

MedlinePLUS

Clinical hemoglobin C ... Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is ... Americans. You are more likely to have hemoglobin C disease if someone in your family has had ...

467

Lung Diseases and Conditions  

MedlinePLUS

... Share this page from the NHLBI on Twitter. Lung Diseases and Conditions Breathing is a complex process. ... your bronchial tubes ( bronchitis ) or deep in your lungs ( pneumonia ). These infections cause a buildup of mucus ...

468

Occupational Respiratory Disease  

MedlinePLUS

... the workplace that can cause lung disease. Poor ventilation, closed-in working areas and heat increase the ... to your supervisor about the need for adequate ventilation and new procedures to reduce or eliminate your ...

469

Interstitial lung disease  

MedlinePLUS

... to the chest Working with or around asbestos, coal dust, cotton dust, and silica dust (called occupational ... routinely screened for lung disease. These jobs include coal mining, sand blasting, and working on a ship.

470

Occupational Lung Diseases  

MedlinePLUS

... disease? Some dusts, such as asbestos, silica, and coal can cause serious scarring (fibrosis) in the lungs. ... Chlorine Gas Lun g Scarring Asbestos Silica Foundry Coal Dust Asbestos Shipyards Sandblasters Brake Manufacturers Latex Beryllium ...

471

Cat scratch disease  

MedlinePLUS

... scratch disease is more serious, and treatment with antibiotics is recommended. ... Children who have a normal immune system should recover fully without treatment. In people with a suppressed immune system, treatment with antibiotics usually leads to recovery.

472

Metastatic Bone Disease  

MedlinePLUS

... activity (i.e., walking or li ing an object) is particularly concerning. Diagnosis Medical History and Physical ... be abnormal in patients with widespread disease. An analysis of the urine (urinalysis) can detect blood, which ...

473

Treatment of Celiac Disease  

MedlinePLUS

... The "gluten" in wheat, barley, rye, contain particular amino acid sequences harmful to persons with celiac disease. Gluten ... is not essential for human health and its amino acid components are replaced many times over in other ...

474

Alzheimer's Disease Genetics  

MedlinePLUS

... Why do some people with memory and other thinking problems develop Alzheimer's while others do not? Determine ... qualified researchers. The participation of volunteers is a critical part of Alzheimer's disease genetics research. The more ...

475

About Chronic Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

476

Diabetes and Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

477

Chronic Kidney Disease  

MedlinePLUS

You have two kidneys, each about the size of your fist. Their main job is to filter wastes and excess water out of ... help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged ...

478

Pregnancy and Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

479

Chronic kidney disease  

MedlinePLUS

Kidney failure - chronic; Renal failure - chronic; Chronic renal insufficiency; Chronic kidney failure; Chronic renal failure ... Chronic kidney disease (CKD) slowly gets worse over months or years. you may not notice any symptoms for some ...

480

Lyme Disease Data  

MedlinePLUS

... the northeast and upper Midwest. Lyme Disease Data File To facilitate the public health and research community's ... Rightâ??click the link and select â??saveâ?ť. File Formats Help: How do I view different file ...

481

Heart Diseases and Disorders  

MedlinePLUS

... very fast, but steady, heartbeat. Sick Sinus Syndrome ( SSS ) Sick sinus syndrome is not a disease, but ... the sinus node, is not working properly. In SSS , the heart rate can alternate between slow ( bradycardia ) ...

482

Parkinson's Disease Foundation  

MedlinePLUS

... All proceeds benefit PDF research programs. Learn More Community Events Saturday, April 25, 2015, 8:30 AM - ... Sponsored Events Parkinson's Disease Foundation Calls Upon the Community to Shape Research During Parkinson's Awareness Month April ...

483

Large scale disease prediction  

E-print Network

The objective of this thesis is to present the foundation of an automated large-scale disease prediction system. Unlike previous work that has typically focused on a small self-contained dataset, we explore the possibility ...

Schmid, Patrick R. (Patrick Raphael)

2008-01-01

484

Learning about Gaucher Disease  

MedlinePLUS

... be adequately degraded. Normally, the body makes an enzyme called glucocerebrosidase that breaks down and recycles glucocerebroside - ... test to measure the activity level of the enzyme glucocerebrosidase. Individuals who have Gaucher disease have very ...

485

Arthritis and Rheumatic Diseases  

MedlinePLUS

... National Institutes of Health (NIH), leads the Federal medical research effort in arthritis and rheumatic diseases. The NIAMS ... The National Institutes of Health (NIH)—The Nation's Medical Research Agency—includes 27 Institutes and Centers and is ...

486

[Pregnancy in Gaucher disease].  

PubMed

Gaucher disease is a lysosomal storage disorder due to deficiency of glucocerebrosidase. The association with pregnancy exposes the worsening of the disease and complications of pregnancy and puerperium. We report a case of pregnancy in a woman of 35 years, suffering from Gaucher disease type 1. Pregnancy had a favorable outcome. Complications occurred. They were kept under control. The outcome was favorable. The authors discuss the evolution of the disease during pregnancy and management of complications. They can occur during pregnancy, post-partum and breastfeeding. Support begins with preconception consultation. It involves finding and correcting the biological problems and deficiencies, and management of complications. Genetic counseling is important, it helps prevent inbreeding. PMID:23578492

Boufettal, H; Quessar, A; Jeddaoui, Z; Mahdoui, S; Noun, M; Hermas, S; Samouh, N

2014-05-01

487

Tay-Sachs Disease  

MedlinePLUS

... years old. In rare forms of the disease, a child may have the HEXA enzyme, but not enough of it to prevent developmental problems. In one of these forms, called juvenile HEXA deficiency, those problems may not appear ...

488

Peripheral artery disease - legs  

MedlinePLUS

... affected artery or arteries for moderate-to-severe cases that are not candidates for surgery. Medicine to ... Most cases of peripheral artery disease of the legs can be controlled without surgery. Although surgery provides good symptom ...

489

Understanding cardiovascular disease  

MedlinePLUS

... leading to the heart. CHD is also called coronary artery disease (CAD). When arteries narrow, the heart can't get ... the heart are involved. High blood pressure and CAD are common causes of heart failure. Arrhythmias are ...

490

Epigenomics and allergic disease  

PubMed Central

Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment. PMID:24283882

Lockett, Gabrielle A; Patil, Veeresh K; Soto-Ramírez, Nelís; Ziyab, Ali H; Holloway, John W; Karmaus, Wilfried

2014-01-01

491

Ebola virus disease  

MedlinePLUS

... monkeys, and chimpanzees). The 2014 Ebola outbreak in West Africa is the largest in history. About 70% of ... One case occurred in a man traveling from West Africa to Texas. He died from the disease. Two ...

492

Pregnancy and Rheumatic Disease  

MedlinePLUS

... outcome than others. What are the effects of pregnancy on rheumatic diseases? During pregnancy, the effects of ... scans during pregnancy. Use of rheumatic drugs during pregnancy and lactation Information regarding the safety of many ...

493

Understanding Autoimmune Diseases  

MedlinePLUS

... Autoimmune Diseases Progress and Promise Key Words The Immune System Your immune system is the network of cells and tissues throughout ... having two parts: the acquired and the innate immune systems. The acquired (or adaptive) immune system develops as ...

494

American Lyme Disease Foundation  

MedlinePLUS

... Publisher [More Information] "Lyme Disease: An Evidence-based Approach" - John J. Halperin, Editor CABI Publisher [More Information] " ... give medical advice. Ordering educational materials and tick identification cards ( orders@aldf.com ) Donations to the ALDF ( ...

495

Lyme Disease Test  

MedlinePLUS

... Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, 12th Edition: Mosby Elsevier Press, St. Louis, MO. ... June 27). Beware of Ticks … & Lyme Disease. U.S. Food and Drug Administration [On-line information]. Available online ...

496

Traveling with Celiac Disease  

MedlinePLUS

... now accommodate people with gluten intolerance, according to Smith, who has celiac disease. By land: If you ... items such as meat, cheese, and yogurt, recommends Smith. You might want to invest in a cooler ...

497

Meningococcal Disease: Risk Factors  

MedlinePLUS

... Travelers to the meningitis belt in sub-Saharan Africa may be at risk for meningococcal disease, particularly during the dry season. ... do I view different file formats (PDF, DOC, PPT, MPEG) on this site? Adobe PDF ...

498

Disease transmission in horses.  

PubMed

Bacterial, viral and protozoal infections may cause severe reproductive losses. The present paper reviews the risk factors, clinical signs and preventive measures for the most important venereal or potential sexually transmitted diseases in horses. The stallion and use of semen for artificial insemination represent major risk factors for the transmission of bacterial contaminants of the penis, including Streptococcus equi subspecies zooepidemicus, Pseudomonas aeruginosa and Klebsiella pneumoniae, known to cause endometritis and infertility in the mare. The role of the stallion in disease transmission is also due to the non-clinical manifestation of diseases such as contagious equine metritis and equine viral arteritis. Dourine has been eradicated from many countries, but continues to be a problem in other areas of the globe. Strategies for the prevention of introduction and transmission of diseases in breeding operation are discussed. PMID:16837034

Samper, Juan C; Tibary, Ahmed

2006-08-01

499

DISEASE REGISTRY TOXICOLOGICAL PROFILES  

EPA Science Inventory

By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, to...

500

Inflammatory Bowel Disease  

MedlinePLUS

... than the digestive tract? How does a healthy digestive system work? How does inflammatory bowel disease interfere with ... separately. Return to top How does a healthy digestive system work? A normal digestive system breaks down food ...