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1

Dimensions of Multiple Personality Disorder  

Microsoft Academic Search

Research on multiple personality disorder (MPD) has burgeoned, and large-scale investigations indicate that a typical MPD patient is a woman, a victim of childhood abuse (especially sexual abuse), a person whose symptoms meet criteria for other psychiatric disorders, and a person who would employ many psychological defenses. Treatment approaches have frequently included hypnotherapy, which requires skill and caution.

John B. Murray

1994-01-01

2

Hypnotherapy of Childhood Multiple Personality Disorder  

Microsoft Academic Search

Although it is widely assumed that multiple personality disorder (MPD) originates in childhood and may exist in some form prior to adolescence, cases of MPD among children were not reported between 1840 and 1979. In this paper five contemporary cases of MPD in childhood are described. In all of these cases hypnosis was used, including that of a youngster who

Richard P. Kluft

1985-01-01

3

Multiple vaccination including serogroup C Meningococcus  

US Patent & Trademark Office Database

Various improvements to vaccines that include a serogroup C meningococcal conjugate antigen, including: (a) co-administration with acellular B. pertussis antigen; (b) co-administration with an inactivated poliovirus antigen; (c) supply in a kit together with a separate pneumococcal conjugate component, which may be in a liquid form; and (d) use in combination with a pneumococcal conjugate antigen but without an aluminum phosphate adjuvant. A kit may have: (a) a first immunogenic component that comprises an aqueous formulation of a conjugated capsular saccharide from Streptococcus pneumoniae; and (b) a second immunogenic component that comprises a conjugated capsular saccharide from Neisseria meningitidis serogroup C.

2013-01-29

4

ON THE MISDIAGNOSIS OF MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

In many mental health settings, there has been an increasingaware- ness that multiple personality disorder (MPD) is far from rare. However, along with this awareness has come an increased incidence of the misdiagnosis of IPD. The misdiagnosis of AIPJ) (i.e., false positive diagnosis of MIPD) has been seen in three forms: other dissociative disorders, non-dissociative disorders, and malingering err factitious

James A. Chu

5

Multiple presentation of mitochondrial disorders  

Microsoft Academic Search

The aim of this study was to assess the heterogeneous clinical presentations of children with mitochondrial disorders evaluated at a metabolic neurogenetic clinic. The charts of 36 children with highly suspected mitochondrial disorders were reviewed. Thirty one children were diagnosed as having a mitochondrial disorder, based on a suggestive clinical presentation and at least one of the accepted laboratory criteria;

Andreea Nissenkorn; Avraham Zeharia; Dorit Lev; Aviva Fatal-Valevski; Varda Barash; Alisa Gutman; Shaul Harel; Tally Lerman-Sagie

1999-01-01

6

Multiple Identity Enactments and Multiple Personality Disorder: A Sociocognitive Perspective  

Microsoft Academic Search

People who enact multiple identities behave as if they possess 2 or more selves, each with its own characteristic moods, memories, and behavioral repertoire. Under different names, this phenomenon occurs in many cultures: in North American culture, it is frequently labeled multiple personality disorder (MPD). This article reviews experimental, cross-cultural, historical, and clinical findings concerning multiplicity and examines the implications

Nicholas P. Spanos

1994-01-01

7

Relationship of Childhood Sexual Abuse to Borderline Personality Disorder, Posttraumatic Stress Disorder, and Multiple Personality Disorder  

Microsoft Academic Search

In this article, I have reviewed recent research into the relationship between childhood sexual abuse and borderline personality disorder, posttraumatic stress disorder, and multiple personality disorder. Evidence that such a relationship exists appears convincing.

John B. Murray

1993-01-01

8

Similarities between near-death experiences and multiple personality disorder  

Microsoft Academic Search

In this paper I compare the phenomenology of near-death experiences to that of multiple personality disorder. The comparison reveals a number of similarities, including out-of-body experiences, the transcendental environment, encounter with the higher self, possible temporal lobe involvement, and antecedent child abuse. Rather than being disparate and unrelated experiences, I suggest that the near-death experience and multiple personality disorder may

William J. Serdahely

1992-01-01

9

[Ocular motor disorders in multiple sclerosis].  

PubMed

Multiple sclerosis is the most common disabling neurological disease in young people. Many neuro-ophthalmological manifestations can occur during the course of the illness, and optic neuritis is both the most frequent and the best known. However, some ocular motility disorders can also occur, but since there may be no symptoms, they often remain underdiagnosed. These eye movement disorders are mostly related to brain-stem and cerebellum lesions. They can be acute, indicating a spatial dissemination of the demyelinating disease, and consequently may indicate the need for systemic treatment of multiple sclerosis. More often, they evolve slowly, progressing with the multiple sclerosis. In this case, they could provide a clue to the prognosis of the disease. In this survey, we discuss the two major symptoms of ocular motor disorders likely to occur during multiple sclerosis: oscillopsia and diplopia. PMID:18971858

Rougier, M-B; Tilikete, C

2008-09-01

10

PERSONS WITH MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

In the past, Internal Self 1lelpers (ISM) of persons with multiple personality rlisorrler OWPI)) have been deseriberl by rr )7mill Humber of therapists. ii is .studV Iwo\\/ens the base ala I inaton relating to ISHs. Forty respondents who collectively had been therapists fur-rr totrtl of 690 i11P1) patients participated in the snarly. 77re findings of this study suti g ges

M. Ann Adams; Ann Adams; M. N. Sc

1989-01-01

11

Sleep disorders in multiple system atrophy  

Microsoft Academic Search

Summary.  Complaints about sleep disorders and excessive daytime sleepiness are common among patients with multiple system atrophy.\\u000a The diffuse neurodegenerative process that encompasses the key structures involved in the regulation of the sleep\\/wake transition\\u000a and respiratory function may account for these complaints and for the most frequent polysomnographic findings in MSA, i.e.,\\u000a sleep-related breathing disturbances and REM sleep behaviour disorder, which

I. Ghorayeb; B. Bioulac; F. Tison

2005-01-01

12

Multiple Substance Use Disorders in Juvenile Detainees.  

ERIC Educational Resources Information Center

Objective: To estimate the 6-month prevalence of multiple substance use disorders (SUDs) among juvenile detainees by demographic subgroups (sex, race/ethnicity, age). Method: Participants were a randomly selected sample of 1,829 African American, non-Hispanic white, and Hispanic detainees (1,172 males, 657 females, aged 10 to 18). Patterns and…

McClelland, Gary M.; Elkington, Katherine S.; Teplin, Linda A.; Abram, Karen M.

2004-01-01

13

Multiple Object Tracking in Autism Spectrum Disorders  

ERIC Educational Resources Information Center

|Difficulties in visual attention are often implicated in autism spectrum disorders (ASD) but it remains unclear which aspects of attention are affected. Here, we used a multiple object tracking (MOT) task to quantitatively characterize dynamic attentional function in children with ASD aged 5-12. While the ASD group performed significantly worse…

Koldewyn, Kami; Weigelt, Sarah; Kanwisher, Nancy; Jiang, Yuhong

2013-01-01

14

Multiple Substance Use Disorders in Juvenile Detainees.  

ERIC Educational Resources Information Center

|Objective: To estimate the 6-month prevalence of multiple substance use disorders (SUDs) among juvenile detainees by demographic subgroups (sex, race/ethnicity, age). Method: Participants were a randomly selected sample of 1,829 African American, non-Hispanic white, and Hispanic detainees (1,172 males, 657 females, aged 10 to 18). Patterns and…

McClelland, Gary M.; Elkington, Katherine S.; Teplin, Linda A.; Abram, Karen M.

2004-01-01

15

THE RATIONAL TREATMENT OF MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

The complex symptomatology of patients who have survived profound childhood abuse, particularly the severe dissociative and post-traumatic symptoms of patients with multiple personality disorder (MPD), may predispose therapists to engage in poorly considered psychotherapeutic practices. Therapists should be careful to keep a rational clinical perspective, and not to be distracted by patients’ unusual and dramatic clinical presentation. This article discusses

JAMES A. CHU

1994-01-01

16

PLAY THERAPY WITH MULTIPLE PERSONALITY DISORDER CLIENTS  

Microsoft Academic Search

The use of play therapy with child alters of adults who have multiple personality disorders is explored. Various approaches to play therapy that are used with children may also be effectively used with child alters. Play may be used to help sublimate expressions of anger, recover dissociated memories, and increase communication and cooperation among alter personalities. Play therapy offers distinct

Jeffrey Wm. Klein; Garry L. Landreth

1993-01-01

17

Multiple Personality Disorder: Concepts and Cases.  

ERIC Educational Resources Information Center

Presents two case examples illustrating nature and etiology of multiple personality disorder in two clients and describing their entry into counseling and progress through treatment. Compares and contrasts cases in areas of diagnosis, symptoms, history, and treatment. Suggests that mental health counselors combine firmness with flexibility in…

Lindsley, Hope L.

1992-01-01

18

Professional Skepticism of Multiple Personality Disorder  

Microsoft Academic Search

If you saw a patient who appeared to have more than one personality, what diagnosis would you make? And how would you vary your clinical approach? Data from 425 respondents indicated that the majority of psychologists believed multiple personality disorder (MPD) to be a valid but rare clinical diagnosis. Respondents cited extreme child abuse as the foremost cause of MPD.

Jane F. Cormier; Mark H. Thelen

1998-01-01

19

Sleep disorders in multiple system atrophy.  

PubMed

Complaints about sleep disorders and excessive daytime sleepiness are common among patients with multiple system atrophy. The diffuse neurodegenerative process that encompasses the key structures involved in the regulation of the sleep/wake transition and respiratory function may account for these complaints and for the most frequent polysomnographic findings in MSA, i.e., sleep-related breathing disturbances and REM sleep behaviour disorder, which are both treatable conditions. Nocturnal stridor is an inspiratory sound produced by complex vocal cord muscle dysfunction. Often occurring with sleep apnoea, stridor is associated with decreased survival. REM sleep behaviour disorder, a parasomnia characterized by loss of normal skeletal muscle atonia during REM sleep with prominent motor activity, is detected in almost all patients. The pathophysiology of both disorders is partially elucidated but increasing evidence points to the role of basal ganglia dysfunction. PMID:16082509

Ghorayeb, I; Bioulac, B; Tison, F

2005-08-05

20

Unusual cases of multiple symmetrical lipomatosis with neurological disorders.  

PubMed

Multiple symmetrical lipomatosis (MSL) is a rare disorder of unknown etiology defined as the presence of multiple and symmetrical fatty accumulations, usually involving the upper trunk, neck and head. Frequently associated findings include diabetes mellitus, hyperlipidemia, liver disease, hypothyroidism and polyneuropathy of unknown origin, but nevertheless, there are published reports of cognitive disorders in patients with MSL. We describe two unusual cases (38-year-old and 45-year-old Greek men) of MSL who presented with polyneuropathy and memory disorders. This is the first description of memory disorders in patients with MSL. We propose that Mini-Mental State Examination and assessment of cognitive functions should be performed for all patients with MSL. The underlying mechanism in our patients remains unknown, and this question should be the subject of a future study. PMID:20048140

Triantafyllou, Nikolaos I; Zalonis, Ioannis; Kararizos, Grigoris; Gkiatas, Konstantinos; Christidi, Fotini; Kararizou, Evangelia

2009-12-01

21

Unusual Cases of Multiple Symmetrical Lipomatosis with Neurological Disorders  

PubMed Central

Multiple symmetrical lipomatosis (MSL) is a rare disorder of unknown etiology defined as the presence of multiple and symmetrical fatty accumulations, usually involving the upper trunk, neck and head. Frequently associated findings include diabetes mellitus, hyperlipidemia, liver disease, hypothyroidism and polyneuropathy of unknown origin, but nevertheless, there are published reports of cognitive disorders in patients with MSL. We describe two unusual cases (38-year-old and 45-year-old Greek men) of MSL who presented with polyneuropathy and memory disorders. This is the first description of memory disorders in patients with MSL. We propose that Mini-Mental State Examination and assessment of cognitive functions should be performed for all patients with MSL. The underlying mechanism in our patients remains unknown, and this question should be the subject of a future study.

Triantafyllou, Nikolaos I.; Zalonis, Ioannis; Kararizos, Grigoris; Gkiatas, Konstantinos; Christidi, Fotini; Kararizou, Evangelia

2009-01-01

22

The Psychophysiological Investigation of Multiple Personality Disorder: Review and Update  

Microsoft Academic Search

In 1984 Putnam reviewed the literature on the psychophysiological investigation of multiple personality disorder (MPD). Since his review, a large number of studies have been conducted and reported in the literature and at professional conferences. Currently, psychophysiologic differences reported in the literature include changes in cerebral electrical activity, cerebral blood flow, galvanic skin response, skin temperature, event-related potentials, neuroendocrine profiles,

Scott D. Miller; Patrick J. Triggiano

1992-01-01

23

Multiple ionization of atoms including post-collisional contributions  

NASA Astrophysics Data System (ADS)

We present a theoretical study on multiple ionization on Ne and Kr by charged ions in the energy range (0.1-10) Mev/amu. We employed the continuum distorted-wave eikonal initial state and a Hartree-Fock description of the dressed-ion, together with photoionization branching ratios to include Auger-type post-collisional contributions. Results are good, especially for Kr targets. Some questions, such as limitations of the independent particle model or influence of the ion charge-state versus the ion nuclear-charge, are analyzed based on the different results for Ne and Kr targets. We found that single ionization is related to the ion charge-state while multiple-ionization shows that the nuclear-charge is weekly screened by the ion outer-electrons.

Montanari, C. C.; Miraglia, J. E.; Wolff, W.; Luna, H.; Santos, A. C. F.; Montenegro, E. C.

2012-11-01

24

Multiple integrated treatment of borderline personality disorders  

Microsoft Academic Search

This paper describes a pilot study of the effectiveness of a specific outpatient programme for Cluster B Personality Disorder. According to this model, the patient is offered a pathway of two?year duration, which includes once a week supportive individual psychotherapy combined with fortnightly group psychotherapy (Dialectical Behavioural Therapy), as well as general psychiatric management.We present the results of a prospective

Euro Pozzi; Maria Elena Ridolfi; Dario Manganaro; Daniel Benyamin Daniel; Domenico Berardi

2008-01-01

25

Multiple object tracking in autism spectrum disorders.  

PubMed

Difficulties in visual attention are often implicated in autism spectrum disorders (ASD) but it remains unclear which aspects of attention are affected. Here, we used a multiple object tracking (MOT) task to quantitatively characterize dynamic attentional function in children with ASD aged 5-12. While the ASD group performed significantly worse overall, the group difference did not increase with increased object speed. This finding suggests that decreased MOT performance is not due to deficits in dynamic attention but instead to a diminished capacity to select and maintain attention on multiple targets. Further, MOT performance improved from 5 to 10 years in both typical and ASD groups with similar developmental trajectories. These results argue against a specific deficit in dynamic attention in ASD. PMID:23104619

Koldewyn, Kami; Weigelt, Sarah; Kanwisher, Nancy; Jiang, Yuhong

2013-06-01

26

Immune-mediated extrapyramidal movement disorders, including Sydenham chorea.  

PubMed

Immune-mediated extrapyramidal movement disorders typically occur in previously healthy children. Immune-mediated movement disorders may occur as a postinfectious, paraneoplastic, or idiopathic process. Sydenham chorea (SC) is the classical poststreptococcal movement and psychiatric disorder, and may be associated with other features of rheumatic fever. The outcome is typically good, although residual chorea, psychiatric disturbance, and relapses are possible. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a syndrome of streptococcal-induced tics and obsessive-compulsive disorder. Although a number of investigators have reported an association between streptococcal infection and neuropsychiatric syndromes, the PANDAS hypothesis is controversial. Encephalitis lethargica is an encephalitic illness with parkinsonism, dyskinesias, and psychiatric disturbance as dominant features. The exact disease mechanism is not understood, although an autoimmune process is suspected. NMDA-R encephalitis is a new entity characterized by encephalitis with dramatic psychiatric disturbance, dyskinesias, cognitive alteration, and seizures. Patients have autoantibodies against the NMDA-R that appear to be pathogenic: immune therapies appear warranted to minimize disability. Movement disorders are also described associated with systemic lupus erythematosus and antiphospholipid syndrome. The differential diagnosis and investigation approach of acute-onset movement disorders are also discussed. PMID:23622334

Dale, Russell C

2013-01-01

27

Personality disorders in first- and multiple-episode mania  

Microsoft Academic Search

We compared rates of DSM-III-R personality disorders in 33 first-episode and 26 multiple-episode bipolar patients. Patients were evaluated with the patient and personality disorders versions of the Structured Clinical Interview for DSM-III-R. Significantly more multiple-episode patients (65%) met DSM-III-R criteria for a personality disorder than did first-episode patients (33%). Race was also associated with a diagnosis of a personality disorder.

Eduardo Dunayevich; Stephen M. Strakowski; Kenji W. Sax; Michael T. Sorter; Paul E. Keck; Susan L. McElroy; Brian J. McConville

1996-01-01

28

Mimicry between mitochondrial disorder and multiple sclerosis.  

PubMed

Under certain conditions or at certain stages of the disease course, multiple sclerosis (MS) and mitochondrial disorder (MID) may be differential diagnoses and thus may be confused with each other. In a 30 years old female MS was diagnosed at age 16 year upon recurrent sensory disturbances of the right lower leg, an "inflammatory" cerebrospinal fluid, and a cerebral MRI with multiple non-enhancing white matter lesions. Steroids were repeatedly given but because of rapid deterioration treatment was switched to interferon and mitoxantrone, without improvement. Fourteen years after onset the patient additionally presented with a history of rhabdomyolysis, hypothyroidism, ophthalmoparesis, anarthria, tetraspasticity, tetraparesis, and joint contractures. After MID had been diagnosed in her mother she was re-evaluated and elevated resting lactate, axonal polyneuropathy, and empty sella were additionally found. Muscle biopsy revealed myophagy, fat deposition, and type-II predominance, and biochemical investigations showed a deficiency of complex I and IV of the respiratory chain. MID was diagnosed also in the index patient. It is concluded that even if CSF investigations or imaging studies suggest MS, differentials such as MIDs need to be excluded before prescribing medication possibly toxic to a MID. An "inflammatory CSF" may also occur in MIDs. PMID:22311611

Finsterer, Josef; Höftberger, Romana; Stöllberger, Claudia; Rolinski, Boris

2012-02-05

29

Psychiatric Disorders in Single and Multiple Sexual Murderers  

Microsoft Academic Search

Background: Sexual homicides – and particularly offenders with multiple victims – receive much attention in the general public as well as among forensic experts. The aim of this study was to assess psychiatric disorders in a large sample of sexual murderers and to identify disorders related to multiple sexual homicides. Sampling and Methods: Psychiatric court reports from 20 German forensic

Andreas Hill; Niels Habermann; Wolfgang Berner; Peer Briken

2007-01-01

30

Multiple disorder diagnosis with adaptive competitive neural networks.  

PubMed

Backpropagation neural networks have repeatedly been used for diagnostic problem-solving, but have not been demonstrated to work well when multiple disorders are present. We hypothesized that letting nodes in a backpropagation neural network compete to be part of a diagnostic solution would produce better performance than the use of existing backpropagation methods. To test this hypothesis, we derived an error backpropagation learning rule that can be used with competitive units (competitive backpropagation). Artificial neural networks were then trained using both this new learning rule and standard error backpropagation on a specific medical diagnosis problem: identification of the location of damage in the brain given a set of examination findings. Training samples included solely 'prototypical' cases where a single location of damage is present. The trained networks were then tested with atypical cases where the manifestations of more than one disorder were present or only a single manifestation was present. Networks employing competition among units were found to perform qualitatively better with these multiple-disorder cases than standard networks and also to perform better on single-manifestation cases. The reasons for this are explained. The competitive backpropagation learning rule described here provides a promising new tool for adaptive diagnostic problem-solving. PMID:8136888

Cho, S; Reggia, J A

1993-12-01

31

The criminal responsibility of people with multiple personality disorder  

Microsoft Academic Search

Because multiple personality disorder (MPD) is more frequently diagnosed today than in the past, it is likely that more multiples will plead insanity. The courts are in a state of disarray as to how best to respond to these pleas. This article considers multiples' responsibility on three interpretations of the status of their alters: that they are different people; that

Elyn R. Saks

1995-01-01

32

42 CFR 137.327 - May multiple projects be included in a single construction project agreement?  

Code of Federal Regulations, 2012 CFR

...multiple projects be included in a single construction project agreement? 137.327 Section...SERVICES TRIBAL SELF-GOVERNANCE Construction Project Assumption Process § 137...multiple projects be included in a single construction project agreement? Yes, a...

2012-10-01

33

42 CFR 137.327 - May multiple projects be included in a single construction project agreement?  

Code of Federal Regulations, 2011 CFR

...multiple projects be included in a single construction project agreement? 137.327 Section...SERVICES TRIBAL SELF-GOVERNANCE Construction Project Assumption Process § 137...multiple projects be included in a single construction project agreement? Yes, a...

2011-10-01

34

From Multiple Personality Disorder to Dissociative Identity Disorder: A Clinical Overview of Diagnostic and Treatment Considerations  

Microsoft Academic Search

This article seeks to enlighten readers about the myriad of clinical issues surrounding the diagnosis of Multiple Personality Disorder (MPD) currently known as Dissociative Identity Disorder (DID). In addition to providing a literature review of the historical development of this complex diagnostic category, it summarizes the etiology and prevalence of the seemingly illusive disorder. Finally, the dichotomy of symptoms, heterogeneity

Karen E. Hart; William Allan Kritsonis

35

Multiple Complex Developmental Disorder Delineated from PDD-NOS  

ERIC Educational Resources Information Center

|The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6-12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity,…

de Bruin, Esther I.; de Nijs, Pieter F. A.; Verheij, Fop; Hartman, Catharina A.; Ferdinand, Robert F.

2007-01-01

36

The Making of Multiple Personality Disorder: A Social Constructionist View  

Microsoft Academic Search

This article explores the social construction of multiple personality disorder by analyzing professional agreements about the nature of the diagnosis, while locating these within their historical and cultural context. First, a historical review of the disorder traces various overlapping streams of discourse that have shaped the construction of the diagnosis. This is followed by a cross-cultural comparison of MPD and

Lina Hartocollis

1998-01-01

37

Hypnosis for Multiple Personality Disorder: A Framework for Beginning  

Microsoft Academic Search

Increasing clinical attention, new research data, media and professional exposure to multiple personality disorder (MPD) make it likely that an increasing number of clinicians will make positive diagnoses. Controversy about the diagnosis persists, and the relationship of hypnosis to the formation of the disorder and to its treatment continues to be a major issue. All of this is likely to

Richard Horevitz

1983-01-01

38

Multiple Personality Disorder: A New Challenge for Psychology  

Microsoft Academic Search

This article reviews the recent literature on multiple personality disorder. Despite a significant increase in the number of publications on this topic during the past 10 years, it is noted that limited knowledge exists on issues such as prevalence rates, differential diagnosis, etiology, and treatment. Psychologists are encouraged to become actively involved in the study of this disorder, and specific

Gary E. Dunn

1992-01-01

39

Multiple personality disorder as perpetrator of child abuse.  

PubMed

An eighteen-month-old Alaskan girl suffered transient coma with multiple superficial contusions when injured by her multiple personality disturbed caretaker. The relative disinterest in multiple personality disorder as a psychiatric diagnosis among American trained practitioners is reflected in the great difficulty encountered by child protection workers while seeking psychotherapy for this disturbed family. The public health nurse, pediatrician, and social workers of the child protection team were unsuccessful in attempting to secure psychiatric therapy for this child batterer. Multiple factors, other than psychiatric community disinterest in multiple personality disorders, influenced these unsuccessful attempts. Legal process delays, strongly punitive community attitudes, tired and nearly "burned out" child protection workers, and conflicting psychological and psychiatric consultant opinions are described. A brief review of multiple personality disorder traits is given with emphasis on the common childhood exposure to abuse and violence among reported multiple personality subjects. Despite the obvious hope by the eighteen-month-old child's parents for effective help to reconstitute her family, the multiple factors described show institutional neglect and abuse which has made such recovery impossible to date. A plea is made to all persons involved with child abuse and neglect to more accurately diagnose and treat multiple personality disorders in abusive parents. PMID:6684972

Brown, G W

1983-01-01

40

Immunophenotyping in multiple myeloma and related plasma cell disorders  

PubMed Central

SUMMARY Plasma cell disorders form a spectrum ranging from the asymptomatic presence of small monoclonal populations of plasma cells to conditions like plasma cell leukemia and multiple myeloma, in which the bone marrow can be replaced by the accumulation of neoplastic plasma cells. Immunophenotyping has become an invaluable tool in the management of hematological malignancies and is increasingly finding a role in the diagnosis and monitoring of plasma cell disorders. Multiparameter flow cytometry has evolved considerably during the past decade with an increasing ability to screen large numbers of events and to detect multiple antigens at the same time. This, along with a better understanding of the phenotypic heterogeneity of the clonal plasma cells in different disorders, has made immunophenotyping an indispensible tool in the diagnosis, prognostic classification and management of plasma cell disorders. This book chapter addresses the approaches taken to evaluate monoclonal plasma cell disorders, and the different markers and techniques that are important for the study of these diseases.

Kumar, Shaji; Kimlinger, Teresa; Morice, William

2010-01-01

41

Movement disorders in multiple sclerosis and other demyelinating diseases.  

PubMed

Multiple sclerosis is an autoimmune inflammatory demyelinating disease of the central nervous system characterized by dissemination of the lesions in time and space. While tremor is frequently seen in patients with multiple sclerosis, other movement disorders such as parkinsonism, dystonia, chorea, ballism, paroxysmal dystonia, paroxysmal chorea, myoclonus, tourettism, restless leg syndrome and hemifacial spasm are less frequently reported. In this systematic review of the literature, we describe the different movement disorders reported in patients with multiple sclerosis and attempt to characterize their relation with the underlying demyelinating process. We also summarize the reports of movement disorders described in other demyelinating diseases such as neuromyelitis optica, acute disseminated encephalomyelitis and central pontine myelinolysis. PMID:23522528

Mehanna, Raja; Jankovic, Joseph

2013-03-19

42

Multiple rare variants in the etiology of autism spectrum disorders  

PubMed Central

Recent studies in autism spectrum disorders (ASDs) support an important role for multiple rare variants in these conditions. This is a clinically important finding, as, with the demonstration that a significant proportion of ASDs are the result of rare, etiological genetic variants, it becomes possible to make use of genetic testing to supplement behavioral analyses for an earlier diagnosis. As it appears that earlier interventions in ASDs will produce better outcomes, the development of genetic testing to augment behaviorally based evaluations in ASDs holds promise for improved treatment. Furthermore, these rare variants involve synaptic and neuronal genes that implicate specific paihvi/ays, cells, and subcellular compartments in ASDs, which in turn will suggest novel therapeutic approaches in ASDs, Of particular recent interest are the synaptic cell adhesion and associated molecules, including neurexin 1, neuroligin 3 and 4, and SHANK3, which implicate glutamatergic synapse abnormalities in ASDs, In the current review we will overview the evidence for a genetic etiology for ASDs, and summarize recent genetic findings in these disorders.

Buxbaum, Joseph D.

2009-01-01

43

Methylphenidate in Children With Oppositional Defiant Disorder and Both Comorbid Chronic Multiple Tic Disorder and ADHD  

Microsoft Academic Search

Our primary objective was to determine if immediate-release methylphenidate is an effective treatment for oppositional defiant disorder diagnosed from mother's report in children with both chronic multiple tic disorder and attention-deficit hyperactivity disorder (ADHD). Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and

Kenneth D. Gadow; Edith E. Nolan; Jeffrey Sverd; Joyce Sprafkin; Jayne Schneider

2008-01-01

44

Outpatient Art Therapy with Multiple Personality Disorder: A Survey of Current Practice.  

ERIC Educational Resources Information Center

Reports findings of a 1993 questionnaire completed by 46 North American art therapists that focuses on the outpatient treatment of multiple personality disorder. Includes information on role in diagnosing, fees and third-party payment, and therapeutic activities. Treatment issues include pacing and containment, and managing the client's chronic…

Mills, Anne

1995-01-01

45

Inducing Order from Disordered Copolymers: On Demand Generation of Triblock Morphologies Including Networks  

SciTech Connect

Disordered block copolymers are generally impractical in nanopatterning applications due to their inability to self-assemble into well-defined nanostructures. However, inducing order in low molecular weight disordered systems permits the design of periodic structures with smaller characteristic sizes. Here, we have induced nanoscale phase separation from disordered triblock copolymer melts to form well-ordered lamellae, hexagonally packed cylinders, and a triply periodic gyroid network structure, using a copolymer/homopolymer blending approach, which incorporates constituent homopolymers into selective block domains. This versatile blending approach allows one to precisely target multiple nanostructures from a single disordered material and can be applied to a wide variety of triblock copolymer systems for nanotemplating and nanoscale separation applications requiring nanoscale feature sizes and/or high areal feature densities.

Tureau, Maëva S.; Kuan, Wei-Fan; Rong, Lixia; Hsiao, Benjamin S.; Epps, III, Thomas H. (Delaware); (SUNYB)

2012-10-26

46

Autobiographical Memory in a Case of Multiple Personality Disorder  

Microsoft Academic Search

Previous research on multiple personality disorder (MPD) has been concerned with between-personalities amnesia, and little attention has been paid to within-personality memory function. This study examined the autobiographical memory of a multiple personality patient, I.C., with cueing procedures that have proven useful in previous studies of normal and abnormal memory. Results indicated that I.C. was able to retrieve autobiographical episodes

Daniel L. Schacter; John F. Kihlstrom; Lucy Canter Kihlstrom; Michael B. Berren

1989-01-01

47

[Dispute over the multiple personality disorder: theoretical or practical dilemma?].  

PubMed

Dissociative identity disorder (DID) could also be referred to as multiple personality disorder (MPD). Due to rare occurrence and difficulty in its' identification it is infrequently diagnosed in Poland. The indicated disorder has been portrayed by the authors throughout the historical context, referring to initial 18th century's references concerning dissociation. A typical dissociatively disordered person has been characterized along with his individual personality categories such as: original personality, altered personality, host and personality fragment. Moreover various diagnosis criterions of DID have been introduced. DID has also been differentiated with other disorders: PTSD (post-traumatic stress disorder) and BPD (borderline personality disorder). A hypothesis has been set up, stating that DID is directly correlated with the trauma experienced during childhood, while PTSD is linked with traumatic lived-through events in the later period of ones' life. The most contemporary and frequently used research tools for DID have been indicated: dissociative experience scale (DES) and somatoform dissociation questionnaire (SDQ-20). Based upon the known literature, the authors have presented treatment methods such as hypnotherapy and recorded therapy sessions. It is the view of the authors that the switching in dissociative identity disorder is of adaptive character (it occurrs depending upon adaptive needs). PMID:17037099

Stankiewicz, Sylwia; Golczy?ska, Maria

48

Rapidly evolving hypopituitarism in a boy with multiple autoimmune disorders.  

PubMed

A 10-year-old boy with acute onset cranial diabetes insipidus and multiple autoimmune disorders had evolving panhypopituitarism, thought to be due to autoimmune hypophysitis. Over 18 months, a dramatic clinical course with progressive hypopituitarism and development of type 1 diabetes mellitus was evident. Serial brain imaging showed changes suggestive of germinoma. PMID:23586429

Jevalikar, Ganesh; Wong, Sze Choong; Zacharin, Margaret

2013-04-16

49

Macromolecular crystal twinning, lattice disorders and multiple crystals  

Microsoft Academic Search

Macromolecule crystal structure analyses can be severely hampered by cases of twinning or of lattice disorders or of multiple crystals. However, it is increasingly the case that twinning can readily be recognized and accounted for, or remediations found. A review of this topic is given, covering both the less-than-perfect and perfect twinning situations. Remediation of twinning cases is possible via

J. R. Helliwell

2008-01-01

50

Indicators of Multiple Personality Disorder for the Clinician.  

ERIC Educational Resources Information Center

Multiple personality disorder (MPD) is now recognized as a valid diagnostic category. Occurrence may be higher than previously suspected. While physiological testing of MPD has shown significant differences between the various personalities of individuals in terms of galvanic skin response, electroencephalogram recordings, electrodermal response…

Dalton, Thomas W.

51

A More Unified View of the Multiple Personality Disorder.  

ERIC Educational Resources Information Center

Offers perspective of Multiple Personality Disorder (MPD) phenomenon based on current clinical experience. Asserts that the Jmind is polypsychic with multitude of psychological systems and processes existing in conjunction with one another, that MPD individuals have fragmented or dissociated ego states due to stress on unity of sense of self, and…

Kelley, Ronald L.; Kodman, Frank

1987-01-01

52

Multiple personality disorder: a clinical and cultural account  

Microsoft Academic Search

After a brief late-19th century epidemic of ‘double consciousness’, multiple personality disorder reappeared in the late 1970s following episodes of the sexual abuse of children. It has been associated with various putative phenomena such as ritual satanic abuse and UFOs. While there is empirical evidence that the separate personalities (‘alters’) have differential psychophysiological characteristics, dispute continues as to the ‘reality’

Roland Littlewood

2004-01-01

53

Treatment Issues in a Case of Possible Multiple Personality Disorder  

Microsoft Academic Search

Amid controversy, the multiple personality disorder and other disturbances involving dissociation provide fertile soil for comparing competing views of psychopathology and treatment. In this article, I describe the treatment of a highly incapacitated patient who presented with severe dissociative symptom atology. The patient was seen in psychoanalytic psychotherapy. The case is discussed in terms of defense, transference, reconstruction, and the

Paul M. Lerner

1994-01-01

54

Satanism, Ritual Abuse, and Multiple Personality Disorder: A Sociohistorical Perspective  

Microsoft Academic Search

During the past decade in North America, a growing number of mental health professionals have reported that between 25% and 50% of their patients in treatment for multiple personality disorder (MPD) have recovered early childhood traumatic memories of ritual torture, incestuous rape, sexual debauchery, sacrificial murder, infanticide, and cannibalism perpetrated by members of clandestine satanic cults. Although hundreds of local

Sherrill Mulhern

1994-01-01

55

Mental Health Professionals' Skepticism About Multiple Personality Disorder  

Microsoft Academic Search

Three studies were conducted to investigate the nature of mental health professionals' skepticism regarding multiple personality disorder (MPD). An initial pilot study was conducted to develop a psychometrically sound survey instrument. In Study 2, the results of a national survey of 207 mental health professionals supported the hypothesis that skepticism and knowledge about MPD are inversely related, r = ?.33,

Jeffrey A. Hayes; Jeffrey C. Mitchell

1994-01-01

56

Effects of Hypnosis on the Features of Multiple Personality Disorder  

Microsoft Academic Search

The authors compared 57 patients with multiple personality disorder (MPD) who had been hypnotized both before and after diagnosis to 38 patients who had not been hypnotized during assessment or treatment. The two groups did not differ on the diagnostic criteria for MPD or in number of personalities. Hypnosis therefore does not have a gross distorting effect on the features

Colin A. Ross; G. Ron Norton

1989-01-01

57

The Simulation and Dissimulation of Multiple Personality Disorder  

Microsoft Academic Search

Forensic consultants have been concerned with an increasing number of cases in which defendants are represented as suffering multiple personality disorder (MPD). This trend may continue and accelerate because 1) more clinicians recognize the condition; 2) a period of reactive overdiagnosis may occur subsequent to decades of underdiagnosis and misdiagnosis; and 3) opportunistic exploitation of MPD as a fraudulent defense

Richard P. Kluft

1987-01-01

58

Multiple Personality Disorder Manifesting Itself under the Mask of Transsexualism  

Microsoft Academic Search

The case of a young female patient is described who presented symptoms of transsexualism; surgical intervention was considered. Admitted to the hospital after having become depressed and suicidal, a thorough examination and observation revealed the presence of multiple personality disorder (MPD). Even though transsexualism and MPD represent two different conditions, there are many similarities between them. The possibility of MPD

J. Modestin; G. Ebner

1995-01-01

59

Field Trips in the Treatment of Multiple Personality Disorder  

Microsoft Academic Search

The treatment of persons with Multiple Personality Disorder often requires innovation and flexibility. A technique is described in which, in certain special situations, a field trip is conducted outside the office and psychotherapy occurs there. A field trip is defined as the conjoint visit of a therapist and a client to a geographic location that has particular emotional significance to

Thomas G. Tudor

1990-01-01

60

On the incidence of multiple personality disorder: A brief communication  

Microsoft Academic Search

Abstraet: Since reporting a case of multiple personality (Eve) over 25 years ago, we have seen many patients who were thought by others or themselves to have the disorder, but we have found only 1 case that fit the diagnosis. The other cases manifested either pseudo- or quasidissociative symptoms related to dissatisfaction with self-identity or hysterical acting out for secondary

Corbett H. Thigpen; Hervey M. Cleckley

1984-01-01

61

Movement observations in multiple personality disorder: A preliminary report  

Microsoft Academic Search

Dance\\/movement therapy, with movement as its unique theoretical and clinical framework, has the potential to contribute to the diagnosis, understanding, and treatment of Multiple Personality Disorder (MPD). The literature on MPD has increased significantly in the past 13 years. Dance\\/movement therapists working in psychiatric facilities are likely to encounter people who carry this diagnosis and, therefore, need to develop a

Estelle S. Kluft; Janis Poteat; Richard P. Kluft

1986-01-01

62

Multiple complex developmental disorder delineated from PDD-NOS.  

PubMed

The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6-12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity, psychotic thought problems and social contact problems using the child behavior checklist/4-18, the Dutch version of the diagnostic interview schedule for children-Version IV, the child and adolescent functional assessment scale, and the autism diagnostic observation schedule-generic. MCDD was associated with anxiety disorders, disruptive behavior, and psychotic thought problems. PDD-NOS was associated with deficits in social contact. MCDD differs from autistic disorder, and can also be delineated from PDD-NOS. PMID:17066306

de Bruin, Esther I; de Nijs, Pieter F A; Verheij, Fop; Hartman, Catharina A; Ferdinand, Robert F

2007-07-01

63

Model for CO2 leakage including multiple geological layers and multiple leaky wells.  

PubMed

Geological storage of carbon dioxide (CO2) is likely to be an integral component of any realistic plan to reduce anthropogenic greenhouse gas emissions. In conjunction with large-scale deployment of carbon storage as a technology, there is an urgent need for tools which provide reliable and quick assessments of aquifer storage performance. Previously, abandoned wells from over a century of oil and gas exploration and production have been identified as critical potential leakage paths. The practical importance of abandoned wells is emphasized by the correlation of heavy CO2 emitters (typically associated with industrialized areas) to oil and gas producing regions in North America. Herein, we describe a novel framework for predicting the leakage from large numbers of abandoned wells, forming leakage paths connecting multiple subsurface permeable formations. The framework is designed to exploit analytical solutions to various components of the problem and, ultimately, leads to a grid-free approximation to CO2 and brine leakage rates, as well as fluid distributions. We apply our model in a comparison to an established numerical solverforthe underlying governing equations. Thereafter, we demonstrate the capabilities of the model on typical field data taken from the vicinity of Edmonton, Alberta. This data set consists of over 500 wells and 7 permeable formations. Results show the flexibility and utility of the solution methods, and highlight the role that analytical and semianalytical solutions can play in this important problem. PMID:19245011

Nordbotten, Jan M; Kavetski, Dmitri; Celia, Michael A; Bachu, Stefan

2009-02-01

64

Multiple Complex Developmental Disorder Delineated from PDD-NOS  

Microsoft Academic Search

The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder\\u000a (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6–12 years)\\u000a with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity, psychotic thought problems\\u000a and social contact problems using the child behavior checklist\\/4–18, the Dutch version of

Esther I. de Bruin; Pieter F. A. de Nijs; Fop Verheij; Catharina A. Hartman; Robert F. Ferdinand

2007-01-01

65

Childhood Trauma and Multiple Personality Disorder: The Case of a 9-Year-Old Girl.  

ERIC Educational Resources Information Center

This paper reports the case of a nine-year-old female victim of sexual abuse, evaluated and diagnosed with multiple personality disorder over a six-month period. Included is a description of the child's presentation with historical and developmental data. A discussion of the dynamic and predisposing features of the case follows, along with…

LaPorta, Lauren D.

1992-01-01

66

Multiple personality disorders: treatment coordination in a partial hospital setting.  

PubMed

Many patients with multiple personality disorder (MPD) can be effectively treated in a partial hospital setting. Partial hospital treatment teams and their patients develop and manage a safe transitional environment that contains the therapy and begins the process of independent functioning in the community. Not all patients with MPD can be treated in partial hospital settings. The author provides guidelines for appropriate placement of these patients. PMID:8401391

Kelly, K A

1993-01-01

67

Incidence and prevalence of multiple allergic disorders recorded in a national primary care database  

PubMed Central

Summary Background The co-existence of allergic conditions, food allergy, eczema, allergic rhinitis, asthma and anaphylaxis is thought to be increasing. Analysis of primary healthcare data-sets offers the possibility to advance understanding about the changing epidemiology of multiple allergic disorders. Aim To investigate recent trends in the recorded incidence, lifetime prevalence and consulting behaviour of patients with multiple allergic disorders in England. Methods QRESEARCH is one of the world's largest national aggregated health databases containing the records of over nine million patients (including those who have left or died). Data were extracted on all patients with a recorded diagnosis of multiple allergic disorders, and annual age–sex standardized incidence and lifetime period prevalence rates were calculated for each year from 2001 to 2005. We also analysed the consulting behaviour of these patients when compared with the rest of the QRESEARCH database population. Results The age–sex standardized incidence of multiple allergic disorders was 4.72 per 1000 person-years in 2001 and increased by 32.9% to 6.28 per 1000 patients in 2005 (p<0.001). Lifetime age–sex standardized prevalence of a recorded diagnosis of multiple allergic disorders increased by 48.9% from 31.00 per 1000 in 2001 to 46.16 in 2005 (p<0.001). Over this period, the mean consultation rate to general practitioners for these patients increased from 4.68 to 4.90 consultations per person per year. Conclusions Recorded incidence and lifetime prevalence of multiple allergic disorders in England have increased substantially in recent years.

Simpson, Colin R; Newton, John; Hippisley-Cox, Julia; Sheikh, Aziz

2008-01-01

68

Including Pupils with Autistic Spectrum Disorders in the Classroom: The Role of Teaching Assistants  

ERIC Educational Resources Information Center

|The aims of the current study were (i) to explore the extent to which pupils with Autistic Spectrum Disorders (ASD) were effectively included in lessons, compared with pupils with dyslexia (DYS) or no Special Educational Needs (CON) and (ii) to understand how the presence of a teaching assistant (TA) influences the inclusion/exclusion process.…

Symes, Wendy; Humphrey, Neil

2012-01-01

69

Should Sluggish Cognitive Tempo Symptoms Be Included in the Diagnosis of Attention-Deficit/hyperactivity Disorder?  

ERIC Educational Resources Information Center

|Objective: To determine the impact of including sluggish cognitive tempo items on the factor and latent class structure of attention-deficit/hyperactivity disorder (ADHD) subtypes in boys and girls. Method: Parent report of two sluggish cognitive tempo items on a population-based sample of 1,430 female twins and 1,414 male twins were analyzed…

Todd, Richard D.; Rasmussen, Erik R.; Wood, Catherine; Levy, Florence; Hay, David A.

2004-01-01

70

Starting Points: Instructional Practices for Young Children Whose Multiple Disabilities Include Visual Impairment.  

ERIC Educational Resources Information Center

This handbook provides basic information on the needs of young children (ages 3-8) whose multiple disabilities include visual impairments. Chapters address: (1) common disabilities associated with visual impairment, the primary educational needs of these children, and the complexity involved in teaching them; (2) the need for clearly defined…

Chen, Deborah; Dote-Kwan, Jamie

71

Unified description for hopping transport in organic semiconductors including both energetic disorder and polaronic contributions  

NASA Astrophysics Data System (ADS)

We developed an analytical model to describe hopping transport in organic semiconductors including both energetic disorder and polaronic contributions due to geometric relaxation. The model is based on a Marcus jump rate in terms of the small-polaron concept with a Gaussian energetic disorder, and it is premised upon a generalized effective medium approach yet avoids shortcomings involved in the effective transport energy or percolation concepts. It is superior to our previous treatment [Phys. Rev. B1098-012110.1103/PhysRevB.76.045210 76, 045210 (2007)] since it is applicable at arbitrary polaron activation energy Ea with respect to the energy disorder parameter ?. It can be adapted to describe both charge-carrier mobility and triplet exciton diffusion. The model is compared with results from Monte Carlo simulations. We show (i) that the activation energy of the thermally activated hopping transport can be decoupled into disorder and polaron contributions whose relative weight depend nonlinearly on the ?/Ea ratio, and (ii) that the choice of the density of occupied and empty states considered in configurational averaging has a profound effect on the results of calculations of the Marcus hopping transport. The ?/Ea ratio governs also the carrier-concentration dependence of the charge-carrier mobility in the large-carrier-concentration transport regime as realized in organic field-effect transistors. The carrier-concentration dependence becomes considerably weaker when the polaron energy increases relative to the disorder energy, indicating the absence of universality. This model bridges a gap between disorder and polaron hopping concepts.

Fishchuk, I. I.; Kadashchuk, A.; Hoffmann, S. T.; Athanasopoulos, S.; Genoe, J.; Bässler, H.; Köhler, A.

2013-09-01

72

An olfactory-limbic model of multiple chemical sensitivity syndrome: Possible relationships to kindling and affective spectrum disorders  

Microsoft Academic Search

This paper reviews the clinical and experimental literature on patients with multiple adverse responses to chemicals (Multiple Chemical Sensitivity Syndrome-MCS) and develops a model for MCS based on olfactory-limbic system dysfunction that overlaps in part with Post's kindling model for affective disorders. MCS encompasses a broad range of chronic polysymptomatic conditions and complaints whose triggers are reported to include low

I. R. Bell; C. S. Miller; G. E. Schwartz

1992-01-01

73

Ca V1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism  

Microsoft Academic Search

CaV1.2, the cardiac L-type calcium channel, is important for excitation and contraction of the heart. Its role in other tissues is unclear. Here we present Timothy syndrome, a novel disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities, and autism. In every case, Timothy syndrome results from

Igor Splawski; Katherine W. Timothy; Leah M. Sharpe; Niels Decher; Pradeep Kumar; Raffaella Bloise; Carlo Napolitano; Peter J. Schwartz; Robert M. Joseph; Karen Condouris; Helen Tager-Flusberg; Silvia G. Priori; Michael C. Sanguinetti; Mark T. Keating

2004-01-01

74

Low Bone Mass Density at Multiple Skeletal Sites, Including the Appendicular Skeleton in Amenorrheic Runners  

Microsoft Academic Search

.   The aim of this study was to investigate any difference in bone mass at different sites between female long-distance runners\\u000a with amenorrhea and those with eumenorrhea. We compared 10 amenorrheic and 10 eumenorrheic athletes to determine whether athletes\\u000a with amenorrhea have lower BMD in multiple skeletal regions, including weight-bearing lower limbs. The amenorrheic group had\\u000a experienced menstrual dysfunction ranging

U. Pettersson; B.-M. Stålnacke; G.-M. Ahlénius; K. Henriksson-Larsén; R. Lorentzon

1999-01-01

75

Nonlocal photopolymerization kinetics including multiple termination mechanisms and dark reactions. Part I. Modeling  

SciTech Connect

The photochemical processes present during free-radical-based holographic grating formation are examined. A kinetic model is presented, which includes, in a more nearly complete and physically realistic way, most of the major photochemical and nonlocal photopolymerization-driven diffusion effects. These effects include: (i) non-steady-state kinetics (ii) spatially and temporally nonlocal polymer chain growth (iii) time varying photon absorption (iv) diffusion controlled viscosity effects (v) multiple termination mechanisms, and (vi) inhibition. The convergence of the predictions of the resulting model is then examined. Comparisons with experimental results are carried out in Part II of this series of papers [J. Opt. Soc. Am. B 26, 1746 (2009)].

Gleeson, Michael R.; Sheridan, John T. [UCD School of Electrical, Electronic and Mechanical Engineering, UCD Optoelectronic Research Centre, and The SFI-Strategic Research Cluster in Solar Energy Conversion, College of Engineering, Mathematical and Physical Sciences, University College Dublin, Belfield, Dublin 4 (Ireland)

2009-09-15

76

Anxiety Symptoms in Boys with Autism Spectrum Disorder, Attention-Deficit Hyperactivity Disorder, or Chronic Multiple Tic Disorder and Community Controls  

Microsoft Academic Search

We compared symptoms of generalized anxiety disorder (GAD) and separation anxiety disorder (SAD) in 5 groups of boys with\\u000a neurobehavioral syndromes: attention-deficit\\/hyperactivity disorder (ADHD) plus autism spectrum disorder (ASD), ADHD plus\\u000a chronic multiple tic disorder (CMTD), ASD only, ADHD only, and community Controls. Anxiety symptoms were assessed using parent\\u000a and teacher versions of a DSM-IV-referenced rating scale. All three groups

Sarit Guttmann-SteinmetzKenneth; Kenneth D. Gadow; Carla J. DeVincent; Judy Crowell

2010-01-01

77

The Effects of Including a Callous Unemotional Specifier for the Diagnosis of Conduct Disorder  

PubMed Central

Background “With Significant Callous-Unemotional Traits” has been proposed as a specifier for Conduct Disorder (CD) in the upcoming revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The impact of this specifier on children diagnosed with CD should be considered. Methods A multi-site cross-sectional design with volunteers (n=1136) in the 3rd-7th grades and 566 consecutive referrals (ages 5-18) to a community mental health center were used to estimate the prevalence rates of CD with and without the proposed specifier. In addition, the degree of emotional and behavioral (especially physical aggression) disturbance and level of impairment in youth with and without CD and with and without the specifier was evaluated. Results In the community sample, 10% to 32% of those with CD and 2% to 7% of those without CD met the callous-unemotional (CU) specifier threshold depending on informant. In the clinic-referred sample, 21% to 50% of those with CD and 14% to 32% without CD met the CU specifier threshold depending on informant. Those with CD and the specifier showed higher rates of aggression in both samples and higher rates of cruelty in the clinic-referred sample. Conclusions Results indicate between 10% and 50% of youth with CD would be designated with the proposed CU specifier. Those with CD and the specifier appear to be more severe on a number of indices, including aggression and cruelty.

Kahn, Rachel E.; Frick, Paul J.; Youngstrom, Eric; Findling, Robert L.; Youngstrom, Jennifer Kogos

2011-01-01

78

Synergy of multiple partners, including freeloaders, increases host fitness in a multispecies mutualism  

PubMed Central

Understanding cooperation is a central challenge in biology, because natural selection should favor “free-loaders” that reap benefits without reciprocating. For interspecific cooperation (mutualism), most approaches to this paradox focus on costs and benefits of individual partners and the strategies mutualists use to associate with beneficial partners. However, natural selection acts on lifetime fitness, and most mutualists, particularly longer-lived species interacting with shorter-lived partners (e.g., corals and zooxanthellae, tropical trees and mycorrhizae) interact with multiple partner species throughout ontogeny. Determining how multiple partnerships might interactively affect lifetime fitness is a crucial unexplored link in understanding the evolution and maintenance of cooperation. The tropical tree Acacia drepanolobium associates with four symbiotic ant species whose short-term individual effects range from mutualistic to parasitic. Using a long-term dataset, we show that tree fitness is enhanced by partnering sequentially with sets of different ant symbionts over the ontogeny of a tree. These sets include a “sterilization parasite” that prevents reproduction and another that reduces tree survivorship. Trees associating with partner sets that include these “parasites” enhance lifetime fitness by trading off survivorship and fecundity at different life stages. Our results demonstrate the importance of evaluating mutualism within a community context and suggest that lifespan inequalities among mutualists may help cooperation persist in the face of exploitation.

Palmer, Todd M.; Doak, Daniel F.; Stanton, Maureen L.; Bronstein, Judith L.; Kiers, E. Toby; Young, Truman P.; Goheen, Jacob R.; Pringle, Robert M.

2010-01-01

79

Synergy of multiple partners, including freeloaders, increases host fitness in a multispecies mutualism.  

PubMed

Understanding cooperation is a central challenge in biology, because natural selection should favor "free-loaders" that reap benefits without reciprocating. For interspecific cooperation (mutualism), most approaches to this paradox focus on costs and benefits of individual partners and the strategies mutualists use to associate with beneficial partners. However, natural selection acts on lifetime fitness, and most mutualists, particularly longer-lived species interacting with shorter-lived partners (e.g., corals and zooxanthellae, tropical trees and mycorrhizae) interact with multiple partner species throughout ontogeny. Determining how multiple partnerships might interactively affect lifetime fitness is a crucial unexplored link in understanding the evolution and maintenance of cooperation. The tropical tree Acacia drepanolobium associates with four symbiotic ant species whose short-term individual effects range from mutualistic to parasitic. Using a long-term dataset, we show that tree fitness is enhanced by partnering sequentially with sets of different ant symbionts over the ontogeny of a tree. These sets include a "sterilization parasite" that prevents reproduction and another that reduces tree survivorship. Trees associating with partner sets that include these "parasites" enhance lifetime fitness by trading off survivorship and fecundity at different life stages. Our results demonstrate the importance of evaluating mutualism within a community context and suggest that lifespan inequalities among mutualists may help cooperation persist in the face of exploitation. PMID:20855614

Palmer, Todd M; Doak, Daniel F; Stanton, Maureen L; Bronstein, Judith L; Kiers, E Toby; Young, Truman P; Goheen, Jacob R; Pringle, Robert M

2010-09-20

80

Pharmacotherapy in the Management of Voiding and Storage Disorders, Including Enuresis and Encopresis  

ERIC Educational Resources Information Center

|Enuresis and encopresis are disorders of the bladder and rectum, and this article helps in understanding the neurobiology of lower urinary tract and anorectal function to help in the treatment of these disorders. Treatment for children with these disorders emphasizes either a psychological or pharmacological approach.|

Reiner, William G.

2008-01-01

81

Eye disorders in patients with multiple sclerosis: natural history and management  

PubMed Central

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and leading cause of disability in young adults. Vision impairment is a common component of disability for this population of patients. Injury to the optic nerve, brainstem, and cerebellum leads to characteristic syndromes affecting both the afferent and efferent visual pathways. The objective of this review is to summarize the spectrum of eye disorders in patients with MS, their natural history, and current strategies for diagnosis and management. We emphasize the most common disorders including optic neuritis and internuclear ophthalmoparesis and include new techniques, such as optical coherence tomography, which promise to better our understanding of MS and its effects on the visual system.

Graves, Jennifer; Balcer, Laura J

2010-01-01

82

Comparative Study of Children with ADHD Only, Autism Spectrum Disorder + ADHD, and Chronic Multiple Tic Disorder + ADHD  

ERIC Educational Resources Information Center

|Objective: Identification of differences among children with ADHD only, autism spectrum disorder (ASD)+ADHD, and chronic multiple tic disorder (CMTD)+ADHD may lead to better understanding of clinical phenotypes. Method: Children were evaluated using the parent- and teacher-completed questionnaires. Results: All three groups were highly similar in…

Gadow, Kenneth D.; DeVincent, Carla J.; Schneider, Jayne

2009-01-01

83

Analytical expressions for the gate utilization factors of passive multiplicity counters including signal build-up  

SciTech Connect

In the realm of nuclear safeguards, passive neutron multiplicity counting using shift register pulse train analysis to nondestructively quantify Pu in product materials is a familiar and widely applied technique. The approach most commonly taken is to construct a neutron detector consisting of {sup 3}He filled cylindrical proportional counters embedded in a high density polyethylene moderator. Fast neutrons from the item enter the moderator and are quickly slowed down, on timescales of the order of 1-2 {micro}s, creating a thermal population which then persists typically for several 10's {micro}s and is sampled by the {sup 3}He detectors. Because the initial transient is of comparatively short duration it has been traditional to treat it as instantaneous and furthermore to approximate the subsequent capture time distribution as exponential in shape. With these approximations simple expressions for the various Gate Utilization Factors (GUFs) can be obtained. These factors represent the proportion of time correlated events i.e. Doubles and Triples signal present in the pulse train that is detected by the coincidence gate structure chosen (predelay and gate width settings of the multiplicity shift register). More complicated expressions can be derived by generalizing the capture time distribution to multiple time components or harmonics typically present in real systems. When it comes to applying passive neutron multiplicity methods to extremely intense (i.e. high emission rate and highly multiplying) neutron sources there is a drive to use detector types with very fast response characteristics in order to cope with the high rates. In addition to short pulse width, detectors with a short capture time profile are also desirable so that a short coincidence gate width can be set in order to reduce the chance or Accidental coincidence signal. In extreme cases, such as might be realized using boron loaded scintillators, the dieaway time may be so short that the build-up (thermalization transient) within the detector cannot be ignored. Another example where signal build-up might be observed is when a {sup 3}He based system is used to track the evolution of the time correlated signal created by a higher multiplying item within a reflective configuration such as the measurement of a spent fuel assembly. In this work we develop expressions for the GUFs which include signal build-up.

Croft, Stephen [Los Alamos National Laboratory; Evans, Louise G [Los Alamos National Laboratory; Schear, Melissa A [Los Alamos National Laboratory

2010-01-01

84

Multiple Personality Disorder and Iatrogenesis: The Cautionary Tale of Anna O  

Microsoft Academic Search

An examination of Breuer's treatment of Anna O. illustrates some of the controversies surrounding the recent rise of case reports of multiple personality disorder. Anna O., the first patient of the cathartic method, psychoanalysis, and dynamic psychiatry, fits current criteria for multiple personality disorder. Breuer's treatment, however, may have contributed to her states of absence; the timing, type, and intensity

Michael Weissberg

1993-01-01

85

Further Notes on a Case of Possible Multiple Personality Disorder: Masochism, Omnipotence, and Entitlement  

Microsoft Academic Search

Multiple personality disorder and other disturbances involving dissociation offer a rich opportunity for extending our understanding of specific psychic phenomenon. Additional clinical material is presented from the treatment of a patient who presented herself as a multiple personality disorder. The patient's attitude of entitlement proved a formidable resistance that ultimately resulted in her prematurely terminating treatment. Using her sense of

Paul M. Lerner; Howard D. Lerner

1996-01-01

86

Belief in the existence of multiple personality disorder among psychologists and psychiatrists.  

PubMed

The present study surveyed the attitudes of psychiatrists and psychologists with regard to the existence of dissociative and multiple personality disorders. Questionnaires were sent to psychiatrists and psychologists in all VA Medical Centers. A total of 1,120 VA psychologists and psychiatrists completed the surveys. More than 97% of respondents indicated that they believed in dissociative disorders, while 80% reported a belief in multiple personality disorder. Belief in multiple personality disorder was related significantly to profession, age, and years of experience. PMID:8071451

Dunn, G E; Paolo, A M; Ryan, J J; Van Fleet, J N

1994-05-01

87

PTSD and Comorbid Disorders in a Representative Sample of Adolescents: The Risk Associated with Multiple Exposures to Potentially Traumatic Events  

ERIC Educational Resources Information Center

|Objective: This study compared the impact of multiple exposures to potentially traumatic events (PTEs), including sexual victimization, physical victimization, and witnessed violence, on posttraumatic stress disorder (PTSD) and comorbid conditions (i.e., major depressive episode [MDE], and substance use [SUD]). Methods: Participants were a…

Macdonald, Alexandra; Danielson, Carla Kmett; Resnick, Heidi S.; Saunders, Benjamin E.; Kilpatrick, Dean G.

2010-01-01

88

The Communication Journey of a Fully Included Child with an Autism Spectrum Disorder  

ERIC Educational Resources Information Center

This article follows Jose, a child with autism spectrum disorder, through his communication journey from age 3 to age 11. His journey illustrates many of the characteristics and challenges of individuals with autism spectrum disorders, as they become a part of the literate community in the general education classroom. Collaborative, family-based…

Diehl, Sylvia F.; Ford, Carolyn S.; Federico, Jeanne

2005-01-01

89

Child Abuse and Multiple Personality Disorders: Review of the Literature and Suggestions for Treatment.  

ERIC Educational Resources Information Center

Multiple personality disorder is associated with a high incidence of physical and sexual abuse during childhood. While difficult to diagnose, multiple personality is easier to treat if diagnosed early in childhood or adolescence. Treatment for multiple personality focuses on establishing trust and communicating with and integrating the…

Coons, Philip M.

1986-01-01

90

Managing persons with multiple personality disorder in a heterogeneous inpatient group  

Microsoft Academic Search

Experts advise against referring persons with multiple personality disorder to diagnostically heterogeneous groups. As more multiples are admitted to inpatient units this presents a problem. Excluding persons of a particular diagnosis from groups makes it difficult to promote a cohesive therapeutic milieu. I have found that multiples can be managed successfully in mixed groups. The leader is advised to adhere

Lisa C. Hogan

1992-01-01

91

Developmental trauma disorder: pros and cons of including formal criteria in the psychiatric diagnostic systems  

PubMed Central

Background This article reviews the current debate on developmental trauma disorder (DTD) with respect to formalizing its diagnostic criteria. Victims of abuse, neglect, and maltreatment in childhood often develop a wide range of age-dependent psychopathologies with various mental comorbidities. The supporters of a formal DTD diagnosis argue that post-traumatic stress disorder (PTSD) does not cover all consequences of severe and complex traumatization in childhood. Discussion Traumatized individuals are difficult to treat, but clinical experience has shown that they tend to benefit from specific trauma therapy. A main argument against inclusion of formal DTD criteria into existing diagnostic systems is that emphasis on the etiology of the disorder might force current diagnostic systems to deviate from their purely descriptive nature. Furthermore, comorbidities and biological aspects of the disorder may be underdiagnosed using the DTD criteria. Summary Here, we discuss arguments for and against the proposal of DTD criteria and address implications and consequences for the clinical practice.

2013-01-01

92

Incorporating Interoperability Functionality for Increasing Patient Safety with PCA-Included Multiple Infusion Therapy  

Microsoft Academic Search

\\u000a Implementation of interoperability in an infusion therapy system intends to enhance safety, by allowing intercommunication\\u000a among medical devices connected to a patient. Some postoperative specific cases entail the patient with multiple drug delivery\\u000a devices. As adverse drug events (ADEs) can occur with the use of infusion pumps, the multiplication of those devices at the\\u000a patient’s bedside establishes the need of

S. M. Krishnan; M. Vanicatte; I. Lee; J. M. Goldman

93

Including Students with Attention-Deficit/Hyperactivity Disorder in Mainstream Schools  

ERIC Educational Resources Information Center

Around 80% of pupils with attention deficit disorders are educated in mainstream schools. The difficulties relating to inattention, impulsivity and hyperactivity experienced by such pupils present mainstream educators with a unique set of challenges and opportunities. In this article, Neil Humphrey, Senior Lecturer in the Psychology of Education…

Humphrey, Neil

2009-01-01

94

A new expanded host range of Cucurbit yellow stunting disorder virus includes three agricultural crops.  

Technology Transfer Automated Retrieval System (TEKTRAN)

Cucurbit yellow stunting disorder virus (CYSDV) was identified in the fall of 2006 affecting cucurbit production in the Imperial Valley of California, the adjacent Yuma, AZ region, as well as nearby Sonora, Mexico. There was nearly universal infection of fall melon crops in 2006 and 2007, and late,...

95

Autistic Spectrum and Inclusion: Including Pupils with Autistic Spectrum Disorders in Mainstream Schools  

ERIC Educational Resources Information Center

|The number of pupils with autistic spectrum disorders (ASD) being educated in mainstream schools is increasing. However, there is growing concern about their educational experiences. Research suggests that such pupils make easy targets for bullies, and are considered difficult to teach by teachers. Furthermore, pupils with ASD are more than 20…

Humphrey, Neil

2008-01-01

96

The Parental Fitness of Mothers with Multiple Personality Disorder: A Preliminary Study.  

ERIC Educational Resources Information Center

A review of the parenting patterns of 75 mothers with multiple personality disorders indicated 38.7% were competent or exceptional mothers, 16% were grossly abusive, and 45.3% were compromised or impaired as parents. (DB)

Kluft, Richard P.

1987-01-01

97

Foot Injuries and Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

... Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Clubfoot Overview English (Arabic) ????? ??????? ??????? - ??????? Multimedia Patient Education Institute Treating Clubfoot with the Ponseti Method English (Arabic) ???????? ????? ...

98

Automatic treatment of multiple wound coils in 3D finite element problems including multiply connected regions  

SciTech Connect

This paper describes an efficient scheme for incorporating multiple wire wound coils into 3D finite element models. The scheme is based on the magnetic scalar representation with an additional basis for each coil. There are no restrictions on the topology of coils with respect to ferromagnetic and conductor regions. Reduced scalar regions and cuts are automatically generated.

Leonard, P.J.; Lai, H.C.; Eastham, J.F.; Al-Akayshee, Q.H. [Univ. of Bath (United Kingdom)

1996-05-01

99

Eating disorders in adolescents: review of treatment studies that include psychodynamically informed therapy.  

PubMed

In clinical practice, psychodynamic approaches represent an important component of the treatment for young people with eating disorders (EDs), even though the research literature remains modest regarding the most effective treatment for children, adolescents, or adults with an ED. Although there are very few clinical research studies of individual or family psychodynamic treatments of EDs, there is some evidence for efficacy from clinical trials. This article reviews studies of psychodynamically informed therapies for the treatment of EDs and discusses how the findings, although limited, suggest that further research into psychodynamic treatments of EDs in youth is warranted. PMID:23164130

Dancyger, Ida; Krakower, Scott; Fornari, Victor

2013-01-01

100

Children at Risk for Learning Disorders: Multiple Perspectives.  

ERIC Educational Resources Information Center

|A study involving 145 Israeli mother-child dyads examined the contribution of a multidimensional model of risk factors in explaining adaptive functioning among kindergartners with mild developmental delays considered at risk for developing learning disorders. Results indicated a high fit between the theoretical model and empirical findings.…

Al-Yagon, Michal

2003-01-01

101

Children at Risk for Learning Disorders: Multiple Perspectives.  

ERIC Educational Resources Information Center

A study involving 145 Israeli mother-child dyads examined the contribution of a multidimensional model of risk factors in explaining adaptive functioning among kindergartners with mild developmental delays considered at risk for developing learning disorders. Results indicated a high fit between the theoretical model and empirical findings.…

Al-Yagon, Michal

2003-01-01

102

Aerosol analysis with the Coastal Zone Color Scanner: a simple method for including multiple scattering effects.  

PubMed

For measurement of aerosols over the ocean, the total radiance L(t) backscattered from the top of a stratified atmosphere which contains both stratospheric and tropospheric aerosols of various types has been computed. A similar computation is carried out for an aerosol-free atmosphere yielding the Rayleigh scattered radiance L(r). The difference L(t) - L(r) is shown to be linearly related to the radiance L(as), which the aerosol would produce in the single scattering approximation. This greatly simplifies the application of aerosol models to aerosol analysis by satellite since adding to, or in some way changing, the aerosol model requires no additional multiple scattering computations. In fact, the only multiple computations required for aerosol analysis are those for determining L(r), which can be performed once and for all. The computations are explicitly applied to Band 4 of the CZCS, which, because of its high radiometric sensitivity and excellent calibration, is ideal for studying aerosols over the ocean. Specifically, the constant A in the relationship L(as) = A(-1)(L(t) - L(r)) is given as a function of position along the scan for four typical orbital-solar position scenarios. The computations show that L(as) can be retrieved from L(t) - L(r) with an average error of no more than 5-7% except at the very edges of the scan. PMID:20548659

Gordon, H R; Castaño, D J

1989-04-01

103

Quality of life in multiple sclerosis patients with urinary disorders: Discriminative validation of the english version of qualiveen  

Microsoft Academic Search

The Qualiveen questionnaire is a urinary disorder (UD)-specific health related quality of life (HRQL) instrument. Recent data suggests Qualiveen has excellent validity in French-speaking multiple sclerosis (MS) patients. Aim: To assess discriminative measurement properties of the English version of Qualiveen. Methods>: Fifty-five Canadian MS out-patients completed a set of questionnaires, including Qualiveen, MSQOL-54, a MS-specific HRQL questionnaire, urinary function assessments

Véronique Bonniaud; Dianne Jackowski; Bernard Parratte; Rick Paulseth; Sharon Grad; Peter Margetts; Gordon Guyatt

2005-01-01

104

Multiple emergences of genetically diverse amphibian-infecting chytrids include a globalized hypervirulent recombinant lineage  

PubMed Central

Batrachochytrium dendrobatidis (Bd) is a globally ubiquitous fungal infection that has emerged to become a primary driver of amphibian biodiversity loss. Despite widespread effort to understand the emergence of this panzootic, the origins of the infection, its patterns of global spread, and principle mode of evolution remain largely unknown. Using comparative population genomics, we discovered three deeply diverged lineages of Bd associated with amphibians. Two of these lineages were found in multiple continents and are associated with known introductions by the amphibian trade. We found that isolates belonging to one clade, the global panzootic lineage (BdGPL) have emerged across at least five continents during the 20th century and are associated with the onset of epizootics in North America, Central America, the Caribbean, Australia, and Europe. The two newly identified divergent lineages, Cape lineage (BdCAPE) and Swiss lineage (BdCH), were found to differ in morphological traits when compared against one another and BdGPL, and we show that BdGPL is hypervirulent. BdGPL uniquely bears the hallmarks of genomic recombination, manifested as extensive intergenomic phylogenetic conflict and patchily distributed heterozygosity. We postulate that contact between previously genetically isolated allopatric populations of Bd may have allowed recombination to occur, resulting in the generation, spread, and invasion of the hypervirulent BdGPL leading to contemporary disease-driven losses in amphibian biodiversity.

Farrer, Rhys A.; Weinert, Lucy A.; Bielby, Jon; Garner, Trenton W. J.; Balloux, Francois; Clare, Frances; Bosch, Jaime; Cunningham, Andrew A.; Weldon, Che; du Preez, Louis H.; Anderson, Lucy; Pond, Sergei L. Kosakovsky; Shahar-Golan, Revital; Henk, Daniel A.; Fisher, Matthew C.

2011-01-01

105

Multiple emergences of genetically diverse amphibian-infecting chytrids include a globalized hypervirulent recombinant lineage.  

PubMed

Batrachochytrium dendrobatidis (Bd) is a globally ubiquitous fungal infection that has emerged to become a primary driver of amphibian biodiversity loss. Despite widespread effort to understand the emergence of this panzootic, the origins of the infection, its patterns of global spread, and principle mode of evolution remain largely unknown. Using comparative population genomics, we discovered three deeply diverged lineages of Bd associated with amphibians. Two of these lineages were found in multiple continents and are associated with known introductions by the amphibian trade. We found that isolates belonging to one clade, the global panzootic lineage (BdGPL) have emerged across at least five continents during the 20th century and are associated with the onset of epizootics in North America, Central America, the Caribbean, Australia, and Europe. The two newly identified divergent lineages, Cape lineage (BdCAPE) and Swiss lineage (BdCH), were found to differ in morphological traits when compared against one another and BdGPL, and we show that BdGPL is hypervirulent. BdGPL uniquely bears the hallmarks of genomic recombination, manifested as extensive intergenomic phylogenetic conflict and patchily distributed heterozygosity. We postulate that contact between previously genetically isolated allopatric populations of Bd may have allowed recombination to occur, resulting in the generation, spread, and invasion of the hypervirulent BdGPL leading to contemporary disease-driven losses in amphibian biodiversity. PMID:22065772

Farrer, Rhys A; Weinert, Lucy A; Bielby, Jon; Garner, Trenton W J; Balloux, Francois; Clare, Frances; Bosch, Jaime; Cunningham, Andrew A; Weldon, Che; du Preez, Louis H; Anderson, Lucy; Pond, Sergei L Kosakovsky; Shahar-Golan, Revital; Henk, Daniel A; Fisher, Matthew C

2011-11-07

106

Circulating angiogenic cytokines in multiple myeloma and related disorders.  

PubMed

We investigated the serum concentrations of selected angiogenic cytokines including: vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), transforming growth factor beta 1 (TGF-beta1) and basic fibroblast growth factor (bFGF) in 162 patients with multiple myeloma (MM), 5 patients with Waldenstr m's macroglobulinaemia (WM), and 31 healthy controls. Among the MM patients there were 2 cases of primary plasma cell leukemia (PCL) and one case of extramedullary plasmacytoma. The levels of measured cytokines were correlated with the phase and stage of the disease as well as the most important clinical and laboratory parameters associated with disease activity (haemoglobin, creatinine, albumins, calcium, M-component, CRP,beta2m, LDH and bone involvement). We have found correlations between serum levels of angiogenic cytokines and some parameters depicting the disease activity and advancement. The serum level of VEGF in MM patients (median 244.5 pg/mL) correlated with serum concentrations of beta-2-microglobulin (beta2m) greater than 2.5 mg/L (p = 0.0005) and abnormal values of lactate dehydrogenase (> 425 U/L, median 329.0 pg/mL and < 210 U/L, median 426.6 pg/mL, p = 0.004 and p = 0.04 respectively). MM patients in stage III had higher serum levels of HGF (median 1 411.3 pg/mL) than those in stage I (median 1 219 pg/mL) (p = 0.01) according to Durie and Salmon staging, and those in phase I (at diagnosis) (median 1 555.6 pg/mL) and phase III (in progression) (median 1 309.7 pg/mL) had higher levels than those in phase II (plateau phase) (median 1 047.9 pg/mL) (p = 0.002 and p = 0.02 respectively). Significantly elevated values of HGF were found in MM patients with anaemia (median 1 962.0 pg/mL) and hypercalcaemia (median 2 085.6 pg/mL) (p = 0.00001 and 0.04 respectively). TGF-beta1 (median 33.9 ng/mL) correlated positively with highbeta2m values (> 2.5 mg/L) (p = 0.04) and was significantly higher in phase I (median 40.1 ng/mL) than in phase II (median 30.9 ng/mL) (p = 0.03) of the disease. The concentration of bFGF was significantly higher in stage III of MM (median 3.1 pg/mL) than in stage I (median 1.2 pg/mL) (p = 0.04). We found that the survival probability was statistically higher for newly diagnosed MM patients with a concentration of VEGF lower than the median value for this cytokine. The concentrations of the cytokines analyzed in patients with Waldenstr m's macroglobulinaemia (WM), primary plasma cell leukaemia (PCL) and non-secretory (NS) myeloma were not distinguishable from those found in MM patients. We also studied the relationship between the levels of cytokines analyzed and found positive correlations between bFGF and TGF-beta1 (rhô = 0.183, p < 0.02), as well as VEGF and TGF-beta 1 (rhô = 0.537, p < 0.001) and VEGF and bFGF (rhô = 0.197, p < 0.02). In conclusion, our data indicate a strong relationship between angiogenic cytokine serum levels and clinical course as well as selected laboratory parameters of patients with MM. PMID:12799213

Urba ska-Rys, Halina; Wierzbowska, Agnieszka; Robak, Tadeusz

107

Use of the Role Checklist with the patient with multiple personality disorder.  

PubMed

A paucity of occupational therapy evaluation tools exists for use with patients with multiple personality disorder. The Model of Human Occupation (Kielhofner & Burke, 1980), particularly the volition and habituation subsystems within this model, proved useful for the identification of the many facets of patients with multiple personality disorder on a short-term treatment unit. The Role Checklist (Oakley, Kielhofner, Barris, & Richler, 1986), a tool derived from the Model of Human Occupation, was adapted for use with this population and was found to be beneficial in the identification of common goals held by most of the personalities of each patient with multiple personality disorder. The use of the Role Checklist is illustrated with a case example. PMID:2252060

Sepiol, J M; Froehlich, J

1990-11-01

108

A controlled study of formal thought disorder in children with autism and multiple complex developmental disorders  

Microsoft Academic Search

Along with well-defined categories in classification systems (e.g., autistic disorders and attention-deficit\\/hyperactivity disorder (ADHD)), practitioners are confronted with many children showing mixed forms of developmental psychopathology. These clusters of symptoms are on the borderlines of more defined categories. The late Donald Cohen proposed heuristic criteria to study a group defined by impaired social sensitivity, impaired regulation of affect, and thinking

R. J. van der Gaag; R. Caplan; H. van Engeland; F. Loman

2005-01-01

109

African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum  

PubMed Central

Plasmodium reichenowi, a chimpanzee parasite, was until very recently the only known close relative of Plasmodium falciparum, the most virulent agent of human malaria. Recently, Plasmodium gaboni, another closely related chimpanzee parasite, was discovered, suggesting that the diversity of Plasmodium circulating in great apes in Africa might have been underestimated. It was also recently shown that P. reichenowi is a geographically widespread and genetically diverse chimpanzee parasite and that the world diversity of P. falciparum is fully included within the much broader genetic diversity of P. reichenowi. The evidence indicates that all extant populations of P. falciparum originated from P. reichenowi, likely by a single transfer from chimpanzees. In this work, we have studied the diversity of Plasmodium species infecting chimpanzees and gorillas in Central Africa (Cameroon and Gabon) from both wild-living and captive animals. The studies in wild apes used noninvasive sampling methods. We confirm the presence of P. reichenowi and P. gaboni in wild chimpanzees. Moreover, our results reveal the existence of an unexpected genetic diversity of Plasmodium lineages circulating in gorillas. We show that gorillas are naturally infected by two related lineages of parasites that have not been described previously, herein referred to as Plasmodium GorA and P. GorB, but also by P. falciparum, a species previously considered as strictly human specific. The continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens.

Prugnolle, Franck; Durand, Patrick; Neel, Cecile; Ollomo, Benjamin; Ayala, Francisco J.; Arnathau, Celine; Etienne, Lucie; Mpoudi-Ngole, Eitel; Nkoghe, Dieudonne; Leroy, Eric; Delaporte, Eric; Peeters, Martine; Renaud, Francois

2010-01-01

110

Investigation of multiple roots of the resistive wall mode dispersion relation, including kinetic effects  

SciTech Connect

The resistive wall mode instability in tokamak plasmas has a complex frequency which can be determined by a dispersion relation that is cubic, in general, leading to three distinct roots. A simplified model of the dispersion relation, including kinetic effects, is presented and used to explore the behavior of these roots. By changing the plasma rotation frequency, it is shown that one root has a slow mode rotation frequency (less than the inverse wall time) while the other two rotate more quickly, one leading and one lagging the plasma rotation frequency. When realistic experimental parameters from the National Spherical Torus Experiment [M. Ono et al., Nucl. Fusion 40, 557 (2000)] are used, however, only one slow rotating, near-marginal stability root is found, consistent with present experiments and more detailed calculations with the MISK code [B. Hu et al., Phys. Plasmas 12, 057301 (2005)]. Electron collisionality acts to stabilize one of the rotating roots, while ion collisionality can stabilize the other. In devices with low rotation and low collisionality, these two rotating roots may manifest themselves, but they are likely to remain stable.

Berkery, J. W.; Sabbagh, S. A. [Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027 (United States); Betti, R. [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States)

2011-07-15

111

Investigation of multiple roots of the resistive wall mode dispersion relation, including kinetic effects  

NASA Astrophysics Data System (ADS)

The resistive wall mode instability in tokamak plasmas has a complex frequency which can be determined by a dispersion relation that is cubic, in general, leading to three distinct roots. A simplified model of the dispersion relation, including kinetic effects, is presented and used to explore the behavior of these roots. By changing the plasma rotation frequency, it is shown that one root has a slow mode rotation frequency (less than the inverse wall time) while the other two rotate more quickly, one leading and one lagging the plasma rotation frequency. When realistic experimental parameters from the National Spherical Torus Experiment [M. Ono et al., Nucl. Fusion 40, 557 (2000)] are used, however, only one slow rotating, near-marginal stability root is found, consistent with present experiments and more detailed calculations with the MISK code [B. Hu et al., Phys. Plasmas 12, 057301 (2005)]. Electron collisionality acts to stabilize one of the rotating roots, while ion collisionality can stabilize the other. In devices with low rotation and low collisionality, these two rotating roots may manifest themselves, but they are likely to remain stable.

Berkery, J. W.; Betti, R.; Sabbagh, S. A.

2011-07-01

112

Joint linkage of multiple loci for a complex disorder  

SciTech Connect

Many investigators who have been searching for linkage to complex diseases have by now accumulated a drawer full of negative results. If disease is actually caused by genes at several loci, these data might contain multiple-locus system (MLS) information that the investigator does not realize. Trying to obtain this information formally, through the MLS likelihood, leads to severe computational and statistical difficulties. Therefore, the authors propose a scheme of inference based on single-locus (SL) statistics, considered jointly. By simulation, they find that the MLS lod score is closely approximated by the sum of SL lod scores. However, they also find that for moderately large systems, say three or four loci, both MLS and SL lod scores are likely to be inconclusive. Nonetheless, MLS can often be detected through the correlation of individual pedigree SL lod scores. Significant correlation is itself evidence of an MLS, because, in the absence of linkage, false-positive lod scores are necessarily random. Under epistasis SL lod scores tend to be positively correlated among pedigrees, while under independent action SL lod scores from high-density samples tend to be negatively correlated. 24 refs., 10 tabs.

MacLean, C.J.; Kendler, K.S.; Sham, P.C. (Virginia Commonwealth Univ., Richmond (United States))

1993-08-01

113

Treatment of Comorbid Attention-Deficit\\/Hyperactivity Disorder and Anxiety in Children: A Multiple Baseline Design Analysis  

Microsoft Academic Search

Objective: The present study evaluated a 10-week psychosocial treatment designed specifically for children with attention-deficit\\/hyperactivity disorder (ADHD) and a comorbid anxiety disorder. Method: Using a nonconcurrent multiple baseline design, the authors treated 8 children ages 8–12 with ADHD, combined type, and at least 1 of 3 major anxiety disorders (separation anxiety disorder, generalized anxiety disorder, social phobia). The integrated treatment

Matthew A. Jarrett; Thomas H. Ollendick

2012-01-01

114

Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis  

Microsoft Academic Search

. Neurological manifestations of gastrointestinal disorders are described, with particular reference to those resembling multiple sclerosis (MS) on clinical or MRI grounds. Patients with celiac disease can present cerebellar ataxia, progressive myoclonic ataxia, myelopathy, or cerebral, brainstem and peripheral nerve involvement. Antigliadin antibodies can be found in subjects with neurological dysfunction of unknown cause, particularly in sporadic cerebellar ataxia (\\

A. Ghezzi; M. Zaffaroni

2001-01-01

115

Defects of intergenomic communication: autosomal disorders that cause multiple deletions and depletion of mitochondrial DNA  

Microsoft Academic Search

Depletion and multiple deletions of mitochondrial DNA (mtDNA) have been associated with a growing number of autosomal diseases that have been classified as defects of intergenomic communication. MNGIE, an autosomal recessive disorder associated with mtDNA alterations is due to mutations in thymidine phosphorylase that may cause imbalance of the mitochondrial nucleotide pool. Subsequently, mutations in the mitochondrial proteins adenine nucleotide

Michio Hirano; Ramon Marti; Claudia Ferreiro-Barros; Maya R Vilà; Saba Tadesse; Yutaka Nishigaki; Ichizo Nishino; Tuan H Vu

2001-01-01

116

Art and multiple personality disorder: an expressive framework for occupational therapy.  

PubMed

Patients with multiple personality and dissociative disorders have learned to create an alternate identity system, originally designed to protect them from experiencing the pain of inescapable, unrelieved trauma and abuse. The resulting amnesia and identity confusion cause significant dysfunction in daily living. Issues of trust and control are paramount, and occupational therapists are challenged with the task of engaging these patients in meaningful activity. Although these patients often avoid structured groups, they have generally been responsive to expressive art opportunities as an initial activity. This paper outlines an expressive framework by which occupational therapists can therapeutically manage the artwork behaviors of the patient with dissociative or multiple personality disorder. The material presented is based on clinical observation of more than a dozen patients with multiple personality disorder in various stages of recovery and of many persons with dissociative trauma who may have multiple personality disorder. These observations took place within an acute care, inpatient occupational therapy setting. Guidelines for the creation of a positive working alliance and therapeutic climate for self-expression are outlined, and a progressive model for the viewing of patients' art products is described. PMID:2252061

Frye, B

1990-11-01

117

Marital and Family Therapy in the Treatment of Multiple Personality Disorder.  

ERIC Educational Resources Information Center

Explores marital and family therapy in treatment of Multiple Personality Disorder (MPD), discussing role of family of origin in MPD development and role of nuclear family in its perpetuation. Suggests family and marital interventions, illustrating them with case examples. Proposes involving MPD client in marital or family therapy, in addition to…

Sachs, Roberta G.; And Others

1988-01-01

118

THE USE OF HEALING CEREMONIES IN THE TREATMENT OF MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

Although talk therapy and abreactive work are crucial in the treat- ment of multiple personality disorder, these techniques do not always assist the client in &ringing closure to other exposed wounds. As a result, some patients continue to feel vulnerable and to doubt their ability to rid themselves of the anguish unleashed fry these uncov- ered memories. Such instances require

Joyce H. Vesper

119

Using Hypnotic Inquiry Protocols to Monitor Treatment Progress and Stability in Multiple Personality Disorder  

Microsoft Academic Search

Thirty-two patients with multiple personality disorder (MPD), who had been integrated for a minimum of 27 months, were reassessed for the stability of their fusions, using a research hypnotic inquiry protocol. The occasional discovery of unsuspected alters or the persistence of alters believed fused led to the protocol's adaptation for monitoring clinical progress and stability. The technique and the patients'

Richard P. Kluft

1985-01-01

120

THE EFFECT OF MULTIPLE PERSONALITY DISORDER ON ANESTHESIA: A CASE REPORT  

Microsoft Academic Search

In the context of studies on the psy chophysiological differences between alterpersonalities in patients with multiple personality disorder (MPD), a patient with diminished need for anesthetics, especially analgesics, during major surgery is described. Psychophysiologic study of MPD patients during anesthesia is recommended, as the relation between doses of medication and their effects can be directly assessed.

Nico Moleman; Jan B. F. Hulscher; Onno van der Hart; D. Nico Moleman; Gert L. Scheepstra

121

A comprehensive review of the literature and case study of multiple personality disorder  

Microsoft Academic Search

Multiple Personality Disorder (MPD) has been the focus of great controversy. Of keen interest in the early 1900's, its study soon after waned precipitously. So sharp was the decline that, until recently, the majority of clinicians gave it little credence. Currently, the literature has reported increasing numbers of such cases, along with varying degrees of success in its treatment.^ This

John Vincent Taliercio

1991-01-01

122

Multiple personality disorder and the choice of self: Change factors in a brief therapy case  

Microsoft Academic Search

A person who identified herself as having a multiple personality disorder made remarkable changes after seven psychotherapeutic sessions and two batteries of tests, one on the alter. The case raises such problematic issues as the diagnosis of MPD, the unitary versus discrete theories and treatment of it, change factors in brief psychotherapy and for all psychotherapy, and the use of

Stephen A. Appelbaum

1996-01-01

123

Autohypnotic Resolution of an Incipient Relapse in an Integrated Multiple Personality Disorder Patient: A Clinical Note  

Microsoft Academic Search

Autohypnotic techniques to monitor the stability of integration were taught to a newly integrated patient who had suffered multiple personality disorder. After 7 years of integration, the patient, in rapid succession, recovered a long-buried traumatic memory and witnessed an extremely upsetting event. Becoming aware of the incipient formation of a new personality to sequester these stressors, she used the autohypnotic

Richard P. Kluft

1988-01-01

124

Preliminary Observations on Age Regression in Multiple Personality Disorder Patients before and after Integration  

Microsoft Academic Search

A review of research data serendipitously revealed that 12 individuals treated successfully for multiple personality disorder (MPD) had undergone age regression procedures both before integration and after 27 months or more of apparently continuous integration. Subjective experiences and reports of historical events during these procedures often differed in the divided and integrated states. Age regression in firmly integrated patients did

Richard P. Kluft

1986-01-01

125

Multiple Personality Disorder: A Risk Indicator, Diagnostic Marker and Psychiatric Outcome for Severe Child Abuse  

Microsoft Academic Search

Recent studies suggest that multiple personality disorder (MPD) is not as rare as previously believed. Indeed, it may represent a relatively common (as many as 25% of cases) outcome of severe physical and sexual abuse of children. Because diagnosis and treatment offer the best prognosis, it is important for the pediatric clinician to become familiar with both the at risk

Barbara Y. Whitman; Wayne Munkel

1991-01-01

126

CONTEMPORARY INTEREST IN MULTIPLE PERSONALITY DISORDER AND CHILD ABUSE IN THE NETHERLANDS  

Microsoft Academic Search

Interest in multiple personality disorder (MPD) as well as sexual child abuse is rapidly growing in the Netherlands, perhaps more so than in otherEuropean countries. Clinical, theoretical, and research developments in these respects are outlined, and it is mentioned that patients stating that they have been victims of satanic cult abuse are also encountered in the Netherlands. The need fin-more

Onno van der Hart; D. Suzette Boon

127

Playing for Time: Temporizing Techniques in the Treatment of Multiple Personality Disorder  

Microsoft Academic Search

The treatment of multiple personality disorder (MPD) is often a prolonged and grueling enterprise, which imposes taxing demands upon the therapist and the patient alike. It becomes quite important to pace the therapy, lest the already beleaguered patient become both acutely and chronically overwhelmed. The majority of the extant literature on the use of hypnosis for the treatment of MPD

Richard P. Kluft

1989-01-01

128

From Dissociation to Negotiation: A Relational Psychoanalytic Perspective on Multiple Personality Disorder  

Microsoft Academic Search

A relational psychoanalytic model for conceptualizing the dynamics and treatment of multiple personality disorder (MPD) is presented, integrating trauma\\/dissociation theories with postclassical psychoanalytic perspectives. MPD is conceptualized as a chronic trauma syndrome and as a particular variation of narcissistic personality organization involving an overreliance on omnipotent defenses, the collapse of intersubjective experiencing and significant derailments of the developmental lines of

Harvey L. Schwartz

1994-01-01

129

CHANGES IN IDENTITY AND SELF-ORGANIZATION IN PSYCHOTHERAPY OF MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

Psychotherapy is the treatment of choice for multiple personality disorder (MPD). Disaggregated identity and self-organization change as the past is reconsidered and the present is reconstructed in therapy. Methods for assessing these changes during treatment are described. A case illustration demonstrates how these findings related to core psychopathology and treatment issues.

VICTOR S. ALPHER

1992-01-01

130

Does the Mind Fall Apart in Multiple Personality Disorder? Some Proposals Based On a Psychoanalytic Case  

Microsoft Academic Search

A psychoanalytic study of some of the phenomena of multiple personality disorder (MPD), this paper takes issue with the view that a falling apart, fragmentation, or disaggregation of the mind is at the bottom of MPD's characteristic symptoms. Since first proposed by Janet in 1889, the view that ordinarily integrated parts of the mind separate from the center, accounting for

Richard M. Gottlieb

1997-01-01

131

Multiple personality disorder in the courts: A review of the North American experience  

Microsoft Academic Search

Multiple personality disorder has increasingly been encountered in the forensic setting in North America over the past 20 years, in particular in relation to competency hearings and insanity defences. The particular legal problems that have arisen are reviewed, the most significant US cases and judicial decisions are explored, and their implications for issues of responsibility, individuality and punishment are discussed.

David James

1998-01-01

132

On Treating the Older Patient with Multiple Personality Disorder: “Race against Time” or “Make Haste Slowly?”  

Microsoft Academic Search

Multiple personality disorder (MPD) is recognized with increasing frequency in child and adult patients, but its discovery and its treatment in patients 60 and over remains rare. Eight MPD patients diagnosed between 60 and 72 years of age were treated. Affectively intense, hypnotically facilitated treatments that are successful in work with younger MPD patients are not always appropriate for the

Richard Kluft

1988-01-01

133

Systems of Selves: the Construction of Meaning in Multiple Personality Disorder  

Microsoft Academic Search

Current models for understanding both Multiple Personality Disorder and human mentation in general are both linear in nature and self-perpetuating insofar as most research in this area has been informed and shaped by extant psychological concepts, paradigms and methods. The research for this dissertation made use of anthropological concepts and methods in an attempt to gain a richer understanding of

Dureen Jean Hughes

1994-01-01

134

The Use of Hypnosis in a Deaf Patient with Multiple Personality Disorder: A Case Report  

Microsoft Academic Search

We present the first report of multiple personality disorder (MPD) in a prelingually deaf patient and the first description of alter personalities as the source of auditory hallucinations in a nonpsychotic deaf person. This young woman's history and clinical symptoms of MPD did not differ from those of hearing patients. A hypnotic trance was induced by instructing the patient in

Elizabeth S. Bowman; Philip M. Coons

1990-01-01

135

Multiple Personality Disorder: Etiology, Treatment, and Treatment Techniques From a Psychodynamic Perspective  

Microsoft Academic Search

Academic psychologists have moved away from psychoanalytic and psychodynamic explanations of human functioning and pathology and have instead embraced neuropsychology and cognitive science. This trend has kept many psychologists and researchers from more fully understanding some of the important phenomena they chose to investigate. One area about which psychologists can learn in the psychodynamic literature is multiple personality disorder (MPD).

Michael Wm. MacGregor

1996-01-01

136

Disorder-induced incoherent scattering losses in photonic crystal waveguides: Bloch mode reshaping, multiple scattering, and breakdown of the Beer-Lambert law  

Microsoft Academic Search

Through a combined theoretical and experimental study of disorder-induced incoherent scattering losses in slow-light photonic crystal slab waveguides, we show the importance of Bloch mode reshaping and multiple scattering. We describe a convenient and fully three-dimensional theoretical treatment of disorder-induced extrinsic scattering, including the calculation of backscatter and out-of-plane losses per unit cell, and the extrapolation of the unit-cell loss

M. Patterson; S. Hughes; S. Schulz; D. M. Beggs; T. P. White; L. O'Faolain; T. F. Krauss

2009-01-01

137

Deficits in adults with Autism Spectrum Disorders when processing multiple objects in dynamic scenes  

PubMed Central

Scientific Abstract People with autism spectrum disorder (ASD) process visual information in a manner that is distinct from typically developing individuals. They may be less sensitive to people's goals and, more generally, focus on visual details instead of the entire scene. To examine these differences, people with and without ASD were asked to detect changes in dynamic scenes with multiple elements. Participants viewed a brief video of a person or an inanimate object moving from one object to another; after a delay, they reported whether a second video was the same or different. Possible changes included the figure, the object the figure was moving from, or the object it was moving toward (the ‘goal’). We hypothesized that individuals with ASD would be less sensitive to changes in scenes with people, particularly elements that might be the person's goal. Alternately, people with ASD might attend to fewer elements regardless of whether the scene included a person. Our results indicate that, like controls, people with ASD noticed a change in the ‘goal’ object at the end of a person's movement more often than the object at the start. However, the group with ASD did not undergo the developmental improvement when detecting changes in start and end objects that was evident typically. This led to deficits in adults with ASD that were not specific to scenes with people or to ‘goals’. Improvements in visual processing that underlie mature representation of scenes may not occur in ASD, suggesting late developing brain processes are affected.

O'Hearn, Kirsten; Lakusta, Laura; Schroer, Elizabeth; Minshew, Nancy; Luna, Beatriz

2010-01-01

138

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide\\/peroxynitrite  

Microsoft Academic Search

Three types of overlap occur among the disease states chronic fatigue syndrome (CFS), fibromyalgia (FM), multiple chemical sensitivity (MCS) and posttraumatic stress disorder (PTSD). They share common symptoms. Many patients meet the criteria for diagnosis for two or more of these disorders and each disorder appears to be often induced by a relatively short-term stress which is followed by a

M. L. Pall

2001-01-01

139

Multiple Informant Agreement on the Anxiety Disorders Interview Schedule in Youth with Autism Spectrum Disorders  

PubMed Central

Abstract Objective The purpose of this study was to examine child, parent, and clinician's consensus agreement on the Anxiety Disorders Interview Schedule, Child and Parent versions (ADIS-C/P) in a sample of children and adolescents with autism spectrum disorders (ASD). Method Youth with ASD (n=85; age range=7–17 years) and their parents were each administered the ADIS-C/P by a trained clinician. Consensus diagnoses were determined in a clinical conference using best estimate procedures that incorporated all available information. Results Children and youth with ASD diagnoses generally showed poor diagnostic agreement with parents and clinical consensus, whereas parents showed good-to-excellent diagnostic agreement with clinical consensus diagnoses. Diagnostic agreement between parents and consensus was moderated by the specific ASD diagnosis. Otherwise, the pattern of relationships did not systematically differ as a function of age or externalizing comorbidity. Conclusions These data suggest that parent and youth agreement regarding the presence of clinical levels of anxiety is markedly poor among youth with ASD. Additionally, clinicians are likely to base their diagnostic impressions on parent report, placing minimal emphasis on child report.

Ehrenreich May, Jill; Wood, Jeffrey J.; Jones, Anna M.; De Nadai, Alessandro S.; Lewin, Adam B.; Arnold, Elysse B.; Murphy, Tanya K.

2012-01-01

140

Transitional case management for reducing recidivism of individuals with mental disorders and multiple misdemeanors.  

PubMed

OBJECTIVE The purpose of this study was to measure the impact of a transitional case management (TCM) program targeted to individuals with mental disorders and multiple arrests for misdemeanor offenses. METHODS The sample included 178 individuals who were diverted from jail at arraignment (N=125) or who voluntarily enrolled in TCM (N=53). Number of arrests and case management sessions attended were compared. RESULTS The mean±SD number of arrests of the 178 participants declined by 31% from the 12 months preenrollment to the 12 months postenrollment. Lifetime arrests and age were significant factors in the count of arrests postenrollment. Diverted and voluntary participants had similar numbers of postenrollment arrests (2.5±3.0 and 2.5±3.5, respectively). Differences in mean postenrollment arrests for diverted participants who completed or did not complete TCM were not significant. Diverted and voluntary participants received an equivalent mean number of case management sessions. CONCLUSIONS Individuals in TCM experienced a reduction in arrests in the 12 months postenrollment. PMID:24026836

Chintakrindi, Sriram; Upton, Allison; Louison, Ann-Marie; Case, Brian; Steadman, Henry J

2013-09-01

141

Diagnostic rules for children with PDD-NOS and multiple complex developmental disorder.  

PubMed

This study was designed to examine the classification performance of diagnostic rules for pervasive developmental disorder not otherwise specified (PDD-NOS) and multiple complex developmental disorder (McDD), with clinical diagnosis as the gold standard. McDD is an heuristic concept of a developmental disorder characterised by social impairments, affective dysregulation, and thought disturbance. Detailed information on the symptoms, reliably extracted from the charts of 103 children with PDD-NOS and McDD, 32 with autistic disorder, and 96 with non-PDD disorders, was used to determine the presence of the DSM-IV criteria of autistic disorder and the criteria of McDD. A scoring rule for PDD-NOS based on a short set of seven DSM-IV criteria with a cut-off point of three items and one social interaction item set as mandatory had the best balance between high sensitivity and high specificity. The most effective and simple rule based on McDD criteria had a cut-off of three items, out of six items of anxieties and thought disturbance. PMID:9758199

Buitelaar, J K; van der Gaag, R J

1998-09-01

142

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder  

PubMed Central

An unanticipated and tremendous amount of the noncoding sequence of the human genome is transcribed. Long noncoding RNAs (lncRNAs) constitute a significant fraction of non-protein-coding transcripts; however, their functions remain enigmatic. We demonstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including lncRNA genes, cause a lethal lung developmental disorder, alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV), with parent-of-origin effects. We identify overlapping deletions 250 kb upstream of FOXF1 in nine patients with ACD/MPV that arose de novo specifically on the maternally inherited chromosome and delete lung-specific lncRNA genes. These deletions define a distant cis-regulatory region that harbors, besides lncRNA genes, also a differentially methylated CpG island, binds GLI2 depending on the methylation status of this CpG island, and physically interacts with and up-regulates the FOXF1 promoter. We suggest that lung-transcribed 16q24.1 lncRNAs may contribute to long-range regulation of FOXF1 by GLI2 and other transcription factors. Perturbation of lncRNA-mediated chromatin interactions may, in general, be responsible for position effect phenomena and potentially cause many disorders of human development.

Szafranski, Przemyslaw; Dharmadhikari, Avinash V.; Brosens, Erwin; Gurha, Priyatansh; Kolodziejska, Katarzyna E.; Zhishuo, Ou; Dittwald, Piotr; Majewski, Tadeusz; Mohan, K. Naga; Chen, Bo; Person, Richard E.; Tibboel, Dick; de Klein, Annelies; Pinner, Jason; Chopra, Maya; Malcolm, Girvan; Peters, Gregory; Arbuckle, Susan; Guiang, Sixto F.; Hustead, Virginia A.; Jessurun, Jose; Hirsch, Russel; Witte, David P.; Maystadt, Isabelle; Sebire, Neil; Fisher, Richard; Langston, Claire; Sen, Partha; Stankiewicz, Pawel

2013-01-01

143

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder.  

PubMed

An unanticipated and tremendous amount of the noncoding sequence of the human genome is transcribed. Long noncoding RNAs (lncRNAs) constitute a significant fraction of non-protein-coding transcripts; however, their functions remain enigmatic. We demonstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including lncRNA genes, cause a lethal lung developmental disorder, alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV), with parent-of-origin effects. We identify overlapping deletions 250 kb upstream of FOXF1 in nine patients with ACD/MPV that arose de novo specifically on the maternally inherited chromosome and delete lung-specific lncRNA genes. These deletions define a distant cis-regulatory region that harbors, besides lncRNA genes, also a differentially methylated CpG island, binds GLI2 depending on the methylation status of this CpG island, and physically interacts with and up-regulates the FOXF1 promoter. We suggest that lung-transcribed 16q24.1 lncRNAs may contribute to long-range regulation of FOXF1 by GLI2 and other transcription factors. Perturbation of lncRNA-mediated chromatin interactions may, in general, be responsible for position effect phenomena and potentially cause many disorders of human development. PMID:23034409

Szafranski, Przemyslaw; Dharmadhikari, Avinash V; Brosens, Erwin; Gurha, Priyatansh; Kolodziejska, Katarzyna E; Zhishuo, Ou; Dittwald, Piotr; Majewski, Tadeusz; Mohan, K Naga; Chen, Bo; Person, Richard E; Tibboel, Dick; de Klein, Annelies; Pinner, Jason; Chopra, Maya; Malcolm, Girvan; Peters, Gregory; Arbuckle, Susan; Guiang, Sixto F; Hustead, Virginia A; Jessurun, Jose; Hirsch, Russel; Witte, David P; Maystadt, Isabelle; Sebire, Neil; Fisher, Richard; Langston, Claire; Sen, Partha; Stankiewicz, Pawe?

2012-10-03

144

Behavioral Treatment of Multiple Childhood Sleep DisordersEffects on Child and Family  

Microsoft Academic Search

Sleep disorders are highlv prevalent among otherwise healthy young children and can be extremelY disruptive to familv life. Treatment was initiated in a multiple baseline fashion for the chronic night waking and nighttime di;t rbance exhibited by a 14-month-old girl. We found that “graduated extinction (gradually increasing the time before attending to the child's crying) resulted in rapid reductions in

V. Niark Durand; Jodi A. Mindell

1990-01-01

145

Multiple-family group treatment as an effective intervention for children with psychological disorders  

Microsoft Academic Search

An estimated 20% of children11Unless otherwise specified, the term children refers to all persons younger than 18 years of age. suffer from psychological disorders and only 10–20% receive adequate treatment. A lack of empirically supported treatments is one reason why relatively few children receive treatment for their psychological difficulties. Multiple-family group treatment (MFGT) is an empirically supported intervention for adults

Michael G. McDonell; Dennis G. Dyck

2004-01-01

146

MULTIPLE PERSONALITY DISORDER AND SATANIC RITUAL ABUSE: THE ISSUE OF CREDIBILITY  

Microsoft Academic Search

The issue of satanic ritual abuse has gained widespread public and professional attention in. the past 10 years. During therapy, many adult AMPI) (multiple personality disorder) patients describe memo- ries of .such abuse beginning in childhood..Simultaneou.sly, there are pre-school children reporting cnrrent incidents of sexual and physical abuse involving salanism in day care settings. Professionals specifi- cally addressing the day

Susan C. Van Benschoten

147

Bariatric Surgery and Multiple Personality Disorder: Complexities and Nuances of Care  

Microsoft Academic Search

Background: Multiple personality disorder (MPD) can occur in patients with morbid obesity in need of bariatric surgery, though\\u000a few reports noting this association exist in the literature. Herein we address MPD in morbid obesity, in the context of a\\u000a patient presenting to us seeking surgical treatment of her morbid obesity. Methods: A 31-year-old morbidly obese (BMI 49 kg\\/m2) Hispanic female

Mark Bloomston; Emmanuel E. Zervos; Pauline S. Powers; Alexander S. Rosemurgy

1997-01-01

148

[Dynamic stabilometry as a monitoring of movement and coordination disorders in the rehabilitation of patients with multiple sclerosis].  

PubMed

Disorders of movement and coordination are the most frequent and debilitating symptoms of multiple sclerosis. It has been shown that distinct changes of balance support are typical of the disease. This report includes an analysis of preliminary positive results of the use of stabilometry and biological feedback for the correction of balance in multiple sclerosis. A test "balance" has been used at baseline of the stabilometric study. After the rehabilitation, the positive changes of balance maintenance were seen in patients with low disability (EDSS<3,5). This test may be used as a measure of rehabilitation effectiveness. The results of the study may provide further determination of the approaches to the development of rehabilitation stabilometric algorithms. PMID:19156084

Popova, N F; Shagaev, A S; Demina, T L; Bo?ko, A N

2009-01-01

149

Selective and Efficient Detection of Nitro-Aromatic Explosives in Multiple Media including Water, Micelles, Organogel, and Solid Support.  

PubMed

Selective detection of nitro-aromatic compounds (NACs) at nanomolar concentration is achieved for the first time in multiple media including water, micelles or in organogels as well as using test strips. Mechanism of interaction of NACs with highly fluorescent p-phenylenevinylene-based molecules has been described as the electron transfer phenomenon from the electron-rich chromophoric probe to the electron deficient NACs. The selectivity in sensing is guided by the pKa of the probes as well as the NACs under consideration. TNP-induced selective gel-to-sol transition in THF medium is also observed through the reorganization of molecular self-assembly and the portable test trips are made successfully for rapid on-site detection purpose. PMID:23992437

Dey, Nilanjan; Samanta, Suman K; Bhattacharya, Santanu

2013-08-30

150

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions.  

PubMed

Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell growth in a variety of cancers. However, the mechanisms are not completely understood, especially in colorectal cancer (CRC). A xenograft tumor model was used first to examine the anti-CRC effect of CK in vivo. Then, multiple in vitro assays were applied to investigate the anticancer effects of CK including antiproliferation, apoptosis and cell cycle distribution. In addition, a qPCR array and western blot analysis were executed to screen and validate the molecules and pathways involved. We observed that CK significantly inhibited the growth of HCT-116 tumors in an athymic nude mouse xenograft model. CK significantly inhibited the proliferation of human CRC cell lines HCT-116, SW-480, and HT-29 in a dose- and time-dependent manner. We also observed that CK induced cell apoptosis and arrested the cell cycle in the G1 phase in HCT-116 cells. The processes were related to the upregulation of p53/p21, FoxO3a-p27/p15 and Smad3, and downregulation of cdc25A, CDK4/6 and cyclin D1/3. The major regulated targets of CK were cyclin dependent inhibitors, including p21, p27, and p15. These results indicate that CK inhibits transcriptional activation of multiple tumor-promoting pathways in CRC, suggesting that CK could be an active compound in the prevention or treatment of CRC. PMID:23434653

Zhang, Zhiyu; Du, Guang-Jian; Wang, Chong-Zhi; Wen, Xiao-Dong; Calway, Tyler; Li, Zejuan; He, Tong-Chuan; Du, Wei; Bissonnette, Marc; Musch, Mark W; Chang, Eugene B; Yuan, Chun-Su

2013-01-31

151

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions  

PubMed Central

Compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell growth in a variety of cancers. However, the mechanisms are not completely understood, especially in colorectal cancer (CRC). A xenograft tumor model was used first to examine the anti-CRC effect of CK in vivo. Then, multiple in vitro assays were applied to investigate the anticancer effects of CK including antiproliferation, apoptosis and cell cycle distribution. In addition, a qPCR array and western blot analysis were executed to screen and validate the molecules and pathways involved. We observed that CK significantly inhibited the growth of HCT-116 tumors in an athymic nude mouse xenograft model. CK significantly inhibited the proliferation of human CRC cell lines HCT-116, SW-480, and HT-29 in a dose- and time-dependent manner. We also observed that CK induced cell apoptosis and arrested the cell cycle in the G1 phase in HCT-116 cells. The processes were related to the upregulation of p53/p21, FoxO3a-p27/p15 and Smad3, and downregulation of cdc25A, CDK4/6 and cyclin D1/3. The major regulated targets of CK were cyclin dependent inhibitors, including p21, p27, and p15. These results indicate that CK inhibits transcriptional activation of multiple tumor-promoting pathways in CRC, suggesting that CK could be an active compound in the prevention or treatment of CRC.

Zhang, Zhiyu; Du, Guang-Jian; Wang, Chong-Zhi; Wen, Xiao-Dong; Calway, Tyler; Li, Zejuan; He, Tong-Chuan; Du, Wei; Bissonnette, Marc; Musch, Mark W.; Chang, Eugene B.; Yuan, Chun-Su

2013-01-01

152

The relationship between multiple sex partners and anxiety, depression, and substance dependence disorders: a cohort study.  

PubMed

Changes in sexual behavior have resulted in longer periods of multiple serial or concurrent relationships. This study investigated the effects of multiple heterosexual partners on mental health, specifically, whether higher numbers of partners were linked to later anxiety, depression, and substance dependency. Data from the Dunedin Multidisciplinary Health and Development Study, a prospective, longitudinal study of a birth cohort born in 1972-1973 in Dunedin, New Zealand were used. The relationship between numbers of sex partners over three age periods (18-20, 21-25, and 26-32 years) and diagnoses of anxiety, depression, and substance dependence disorder at 21, 26, and 32 years were examined, using logistic regression. Interaction by gender was examined. Adjustment was made for prior mental health status. There was no significant association between number of sex partners and later anxiety and depression. Increasing numbers of sex partners were associated with increasing risk of substance dependence disorder at all three ages. The association was stronger for women and remained after adjusting for prior disorder. For women reporting 2.5 or more partners per year, compared to 0-1 partners, the adjusted odd ratios (and 95 % CIs) were 9.6 (4.4-20.9), 7.3 (2.5-21.3), and 17.5 (3.5-88.1) at 21, 26, and 32 years, respectively. Analyses using new cases of these disorders showed similar patterns. This study established a strong association between number of sex partners and later substance disorder, especially for women, which persisted beyond prior substance use and mental health problems more generally. The reasons for this association deserve investigation. PMID:23400516

Ramrakha, Sandhya; Paul, Charlotte; Bell, Melanie L; Dickson, Nigel; Moffitt, Terrie E; Caspi, Avshalom

2013-02-12

153

Coamplification of multiple regions of chromosome 2, including MYCN, in a single patchwork amplicon in cancer cell lines.  

PubMed

Coamplification of multiple segments of chromosome 2, including an MYCN-bearing segment, was examined in 2 cancer cell lines, NCI-H69 (lung cancer) and IMR-32 (neuroblastoma). High-resolution array-CGH analysis revealed 13 and 6 highly amplified segments located at different sites in chromosome 2 in NCI-H69 and IMR-32, respectively. FISH analysis demonstrated that these segments were co-localized in double minutes in NCI-H69 and in homogeneously staining regions in IMR-32. Connectivity of the segments was determined by a PCR assay using designed primer sets. It was found that all the segments were connected to each other irrespective of their order and orientation against the genome sequence, and a single chain-like cluster was configured in both cell lines. Such patchwork structures of the amplicons suggest the possibility that massive genomic rearrangements, explained by the single catastrophic event model, are involved in the formation of the amplicons, enabling the coamplification of different chromosomal regions including the MYCN locus. The model comprises massive fragmentation of chromosomes and random rejoining of the fragments. PMID:22123490

Kitada, K; Aida, S; Aikawa, S

2011-11-23

154

Multiple informants: mortality associated with psychiatric disorders in the Stirling County Study.  

PubMed

This paper applies new statistical procedures for analyzing multiple-source information about the relation of psychiatric diagnoses to mortality. The data come from the Stirling County Study, a longitudinal community investigation of adults, that collected multiple-source reports (self-report and physician-report) about psychiatric disorders. These reports are used as predictors of mortality risk over a 16-year follow-up period (1952-1968). Despite extensive efforts, one or both of these reports were sometimes missing. Missingness of self-report was related to demographic characteristics as well as to physician-reports of psychiatric diagnosis. The statistical procedures used here draw together into a single frame of reference both informant reports for the initial Stirling survey and relate these to mortality risk using weighted generalized estimating equation regression models for time to event data. This unified method has two advantages over traditional approaches: 1) the relative predictiveness of each informant can be assessed and 2) all subjects contribute to the analysis. The methods are applicable to other areas of epidemiology where multiple informant reports are used. The results for self-reports and physician-reports of disorders were comparable: Psychiatric diagnosis was associated with higher mortality, particularly among younger subjects. PMID:11581099

Horton, N J; Laird, N M; Murphy, J M; Monson, R R; Sobol, A M; Leighton, A H

2001-10-01

155

Sensory and sensorimotor gating in children with multiple complex developmental disorders (MCDD) and autism.  

PubMed

Multiple Complex Developmental Disorder (MCDD) is a well-defined and validated behavioral subtype of autism with a proposed elevated risk of developing a schizophrenic spectrum disorder. The current study investigated whether children with MCDD show the same deficits in sensory gating that are commonly reported in schizophrenia, or whether they are indistinguishable from children with autism in this respect. P50 suppression and prepulse inhibition (PPI) of the startle reflex were assessed in children with MCDD (n=14) or autism (n=13), and healthy controls (n=12), matched on age and IQ. All subjects showed high levels of PPI and P50 suppression. However, no group differences were found. No abnormalities in sensory filtering could be detected in children with autism or MCDD. Since sensory gating deficits are commonly regarded as possible endophenotypic markers for schizophrenia, the current results do not support a high level of similarity between schizophrenia and MCDD. PMID:23164481

Oranje, Bob; Lahuis, Bertine; van Engeland, Herman; Jan van der Gaag, Rutger; Kemner, Chantal

2012-11-16

156

Prenatal diagnosis and genetic analysis of fetal akinesia deformation sequence and multiple pterygium syndrome associated with neuromuscular junction disorders: a review.  

PubMed

Fetal akinesia deformation sequence is a clinically and genetically heterogeneous disorder characterized by a variable combination of arthrogryposis, fetal akinesia, intrauterine growth restriction, developmental abnormalities such as cystic hygroma, pulmonary hypoplasia, cleft palate, cryptorchidism, cardiac defects and intestinal malrotation, and occasional pterygia of the limbs. Multiple pterygium syndrome is a clinically and genetically heterogeneous disorder characterized by pterygia of the neck, elbows and/or knees, arthrogryposis, and other phenotypic features such as short stature, genital abnormalities, craniofacial abnormalities, clubfoot, kyphoscoliosis, and cardiac abnormalities. Fetal akinesia deformation sequence may phenotypically overlap with the lethal type of multiple pterygium syndrome. This article provides a comprehensive review of prenatal diagnosis and genetic analysis of fetal akinesia deformation sequence and multiple pterygium syndrome associated with neuromuscular junction disorders. Prenatal diagnosis of fetal akinesia along with cystic hygroma, increased nuchal translucency, nuchal edema, hydrops fetalis, arthrogryposis, pterygia, and other structural abnormalities should include a differential diagnosis of neuromuscular junction disorders. Genetic analysis of mutations in the neuromuscular junction genes such as CHRNA1, CHRND, CHRNG, CNTN1, DOK7, RAPSN, and SYNE1 may unveil the pathogenetic cause of fetal akinesia deformation sequence and multiple pterygium syndrome, and the information acquired is helpful for genetic counseling and clinical management. PMID:22482962

Chen, Chih-Ping

2012-03-01

157

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.  

PubMed

We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124 autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected parents, and, in most kindreds, an unaffected sibling. We find significant association of ASD with de novo duplications of 7q11.23, where the reciprocal deletion causes Williams-Beuren syndrome, characterized by a highly social personality. We identify rare recurrent de novo CNVs at five additional regions, including 16p13.2 (encompassing genes USP7 and C16orf72) and Cadherin 13, and implement a rigorous approach to evaluating the statistical significance of these observations. Overall, large de novo CNVs, particularly those encompassing multiple genes, confer substantial risks (OR = 5.6; CI = 2.6-12.0, p = 2.4 × 10(-7)). We estimate there are 130-234 ASD-related CNV regions in the human genome and present compelling evidence, based on cumulative data, for association of rare de novo events at 7q11.23, 15q11.2-13.1, 16p11.2, and Neurexin 1. PMID:21658581

Sanders, Stephan J; Ercan-Sencicek, A Gulhan; Hus, Vanessa; Luo, Rui; Murtha, Michael T; Moreno-De-Luca, Daniel; Chu, Su H; Moreau, Michael P; Gupta, Abha R; Thomson, Susanne A; Mason, Christopher E; Bilguvar, Kaya; Celestino-Soper, Patricia B S; Choi, Murim; Crawford, Emily L; Davis, Lea; Wright, Nicole R Davis; Dhodapkar, Rahul M; DiCola, Michael; DiLullo, Nicholas M; Fernandez, Thomas V; Fielding-Singh, Vikram; Fishman, Daniel O; Frahm, Stephanie; Garagaloyan, Rouben; Goh, Gerald S; Kammela, Sindhuja; Klei, Lambertus; Lowe, Jennifer K; Lund, Sabata C; McGrew, Anna D; Meyer, Kyle A; Moffat, William J; Murdoch, John D; O'Roak, Brian J; Ober, Gordon T; Pottenger, Rebecca S; Raubeson, Melanie J; Song, Youeun; Wang, Qi; Yaspan, Brian L; Yu, Timothy W; Yurkiewicz, Ilana R; Beaudet, Arthur L; Cantor, Rita M; Curland, Martin; Grice, Dorothy E; Günel, Murat; Lifton, Richard P; Mane, Shrikant M; Martin, Donna M; Shaw, Chad A; Sheldon, Michael; Tischfield, Jay A; Walsh, Christopher A; Morrow, Eric M; Ledbetter, David H; Fombonne, Eric; Lord, Catherine; Martin, Christa Lese; Brooks, Andrew I; Sutcliffe, James S; Cook, Edwin H; Geschwind, Daniel; Roeder, Kathryn; Devlin, Bernie; State, Matthew W

2011-06-01

158

Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development.  

PubMed

Bone morphogenetic proteins (BMPs) have multiple roles during embryogenesis. Current data indicate that the dosage of BMPs is tightly regulated for normal development in mice. Since Bmp2 or Bmp4 homozygous mutant mice show early embryonic lethality, we generated compound heterozygous mice for Bmp2 and Bmp4 to explore the impact of lowered dosage of these BMP ligands. Genotyping pups bred between Bmp2 and Bmp4 heterozygous mice revealed that the ratio of adult compound heterozygous mice for Bmp2 and Bmp4 is much lower than expected. During embryogenesis, the compound heterozygous embryos showed several abnormalities, including defects in eye formation, body wall closure defects, and ventricular septal defects (VSD) in the heart. However, the ratio of the compound heterozygous embryos was the same as expected. Caesarean sections at E18.5 revealed that half of the compound heterozygotes died soon after birth, and the majority of the dead individuals exhibited VSD. Survivors were able to grow to adults, but their body weight was significantly lower than control littermates. They demonstrated progressive abnormalities in the heart, eventually showing a branched leaflet in atrioventricular valves. These results suggest that the dosage of both BMP2 and 4 is critical for functional heart formation during embryogenesis and after birth. PMID:19391114

Uchimura, Takashi; Komatsu, Yoshihiro; Tanaka, Momo; McCann, Kelly L; Mishina, Yuji

2009-06-01

159

Overcoming the Diffraction Limit Using Multiple Light Scattering in a Highly Disordered Medium  

PubMed Central

We report that disordered media made of randomly distributed nanoparticles can be used to overcome the diffraction limit of a conventional imaging system. By developing a method to extract the original image information from the multiple scattering induced by the turbid media, we dramatically increase a numerical aperture of the imaging system. As a result, the the resolution is enhanced by more than five times over the diffraction limit and a field of view is extended over the physical area of the camera. Our technique lays the foundation to use a turbid medium as a far-field superlens.

Choi, Youngwoon; Yang, Taeseok Daniel; Fang-Yen, Christopher; Kang, Pilsung; Lee, Kyoung Jin; Dasari, Ramachandra R.; Feld, Michael S.; Choi, Wonshik

2012-01-01

160

A problem decomposition method for efficient diagnosis and interpretation of multiple disorders.  

PubMed

Diagnosis of multiple disorders can be made more efficient by reasoning explicitly about problem decompositions. A diagnostic problem can be decomposed by hypothesizing about common and disjoint cause relationships among the given symptoms. The resulting structure exploits computational principles of causal intersection, subproblem independence, and minimal factorability to increase efficiency. By assigning structure to a problem, the symptom decomposition approach offers a new type of decision-support task called symptom interpretation. Experimental results indicate that symptom decomposition yields substantial increases in performance compared to existing methods for multidisorder diagnosis. PMID:1752119

Wu, T D

1991-08-01

161

Unsupervised Integration of Multiple Protein Disorder Predictors: The Method and Evaluation on CASP7, CASP8 and CASP9 Data  

PubMed Central

Background Studies of intrinsically disordered proteins that lack a stable tertiary structure but still have important biological functions critically rely on computational methods that predict this property based on sequence information. Although a number of fairly successful models for prediction of protein disorder have been developed over the last decade, the quality of their predictions is limited by available cases of confirmed disorders. Results To more reliably estimate protein disorder from protein sequences, an iterative algorithm is proposed that integrates predictions of multiple disorder models without relying on any protein sequences with confirmed disorder annotation. The iterative method alternately provides the maximum a posterior (MAP) estimation of disorder prediction and the maximum-likelihood (ML) estimation of quality of multiple disorder predictors. Experiments on data used at CASP7, CASP8, and CASP9 have shown the effectiveness of the proposed algorithm. Conclusions The proposed algorithm can potentially be used to predict protein disorder and provide helpful suggestions on choosing suitable disorder predictors for unknown protein sequences.

2011-01-01

162

MPV17 Mutations Causing Adult-Onset Multisystemic Disorder With Multiple Mitochondrial DNA Deletions.  

PubMed

OBJECTIVE To identify the cause of an adult-onset multisystemic disease with multiple deletions of mitochondrial DNA (mtDNA). DESIGN Case report. SETTING University hospitals. PATIENT A 65-year-old man with axonal sensorimotor peripheral neuropathy, ptosis, ophthalmoparesis, diabetes mellitus, exercise intolerance, steatohepatopathy, depression, parkinsonism, and gastrointestinal dysmotility. RESULTS Skeletal muscle biopsy revealed ragged-red and cytochrome- c oxidase-deficient fibers, and Southern blot analysis showed multiple mtDNA deletions. No deletions were detected in fibroblasts, and the results of quantitative polymerase chain reaction showed that the amount of mtDNA was normal in both muscle and fibroblasts. Exome sequencing using a mitochondrial library revealed compound heterozygous MPV17 mutations (p.LysMet88-89MetLeu and p.Leu143*), a novel cause of mtDNA multiple deletions. CONCLUSIONS In addition to causing juvenile-onset disorders with mtDNA depletion, MPV17 mutations can cause adult-onset multisystemic disease with multiple mtDNA deletions. PMID:22964873

Garone, Caterina; Rubio, Juan Carlos; Calvo, Sarah E; Naini, Ali; Tanji, Kurenai; Dimauro, Salvatore; Mootha, Vamsi K; Hirano, Michio

2012-12-01

163

Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders  

PubMed Central

Objective The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. Method A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). Results At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. Conclusion The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations.

Riedel, Michael; Messer, Thomas; Laux, Gerd; Pfeiffer, Herbert; Naber, Dieter; Schmidt, Lutz G.; Gaebel, Wolfgang; Huff, Wolfgang; Heuser, Isabella; Kuhn, Kai-Uwe; Lemke, Matthias R.; Ruther, Eckart; Buchkremer, Gerhard; Gastpar, Markus; Bottlender, Ronald; Strauss, Anton; Moller, Hans-Jurgen

2006-01-01

164

Exploring the Social Impact of Being a Typical Peer Model for Included Children with Autism Spectrum Disorder  

ERIC Educational Resources Information Center

|This study examined the social impact of being a typical peer model as part of a social skills intervention for children with autism spectrum disorder (ASD). Participants were drawn from a randomized-controlled-treatment trial that examined the effects of targeted interventions on the social networks of 60 elementary-aged children with ASD.…

Locke, Jill; Rotheram-Fuller, Erin; Kasari, Connie

2012-01-01

165

Including an analysis of difficult behaviour in the assessment of children with an autism spectrum disorder: Implications for school psychologists  

Microsoft Academic Search

School psychologists who contribute to the assessment of children with an autism spectrum disorder (ASD) are required by various Australian state government authorities to use standardised testing of cognitive skills, adaptive behaviour and some autism-based symptomatology to demonstrate the eligibility of those children for support funding in the school environment. However, this process does not always address the needs of

Vicki Bitsika

2008-01-01

166

Relationship between Temporomandibular Disorders, Widespread Palpation Tenderness and Multiple Pain Conditions: A Case - Control Study  

PubMed Central

The multiple bodily pain conditions in temporomandibular disorders (TMD) have been associated with generalized alterations in pain processing. The purpose of this study was to examine the relationship between the presence of widespread body palpation tenderness (WPT) and the likelihood of multiple comorbid pain conditions in TMD patients and controls. This case-control study was conducted in 76 TMD subjects with WPT, 83 TMD subjects without WPT, and 181 non-TMD matched control subjects. The study population was also characterized for clinical pain, experimental pain sensitivity, and related psychological phenotypes. Results showed that (1) TMD subjects reported an average of 1.7 comorbid pain conditions compared to 0.3 reported by the control subjects (p<0.001); (2) Compared to control subjects, the odds ratio (OR) for multiple comorbid pain conditions is higher for TMD subjects with WPT [OR 8.4 (95% CI 3.1–22.8) for TMD with WPT versus OR 3.3 (95% CI 1.3–8.4) for TMD without WPT]; (3) TMD subjects with WPT presented with reduced pressure pain thresholds (PPTs) in both cranial and extra-cranial regions compared to TMD subjects without WPT; and (4) TMD subjects with WPT reported increased somatic symptoms. These findings suggest that pain assessment outside of the orofacial region may prove valuable for the classification, diagnosis, and management of TMD patients.

Chen, Hong; Slade, Gary; Lim, Pei Feng; Miller, Vanessa; Maixner, William; Diatchenko, Luda

2012-01-01

167

Flt3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease  

Microsoft Academic Search

We screened 115 patients with chronic myeloid disorders (CMD) for known flt-3 and c-kit mutations in both the juxtamembrane (JM) and the activation loop (AL) domains. None of the patients displayed flt-3 (JM or AL) or c-kit JM mutations. However, the c-kit AL (D816V) mutation was detected in 5 of 16 patients with systemic mast cell disease (SMCD) but in

Animesh Pardanani; Terra L. Reeder; Teresa K. Kimlinger; Jin Y. Baek; Chin-Y. Li; Joseph H. Butterfield; Ayalew Tefferi

2003-01-01

168

Disordering Effects of Color in Nonequilibrium Phase Transitions Induced by Multiplicative Noise  

NASA Astrophysics Data System (ADS)

The model introduced by Van den Broeck, Parrondo, and Toral [Phys. Rev. Lett. 73, 3395 (1994)]-leading to a second-order-like noise-induced nonequilibrium phase transition which shows reentrance as a function of the (multiplicative) noise intensity ?-is investigated beyond the white-noise assumption. Through a Markovian approximation and within a mean-field treatment it is found that, in striking contrast with the usual behavior for equilibrium phase transitions, for noise self-correlation time ?>0, the stable phase for (diffusive) spatial coupling D-->? is always the disordered one. Another surprising result is that a large noise ``memory'' also tends to destroy order. These results are supported by numerical simulations.

Mangioni, S.; Deza, R.; Wio, H. S.; Toral, R.

1997-09-01

169

Taxonic structure of schizotypal personality disorder: A multiple-instrument, multi-sample study based on mixture models  

Microsoft Academic Search

This study used a multi-sample, multiple-instrument strategy to evaluate the hypothesis that schizotypal personality disorder (SPD) is taxonic. In Study 1, 721 consecutively admitted inpatients and outpatients were evaluated with the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) and the Personality Diagnostic Questionnaire-4+ (PDQ-4+). The data from both questionnaire types were submitted to multivariate normal mixture analysis,

Andrea Fossati; Alessandra Citterio; Federica Grazioli; Serena Borroni; Ilaria Carretta; Cesare Maffei; Marco Battaglia

2005-01-01

170

?-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites  

Microsoft Academic Search

Harmine, a ?-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21. We and others have implicated DYRK1A in the phosphorylation of tau protein on multiple sites associated with tau pathology in Down Syndrome and in Alzheimer's

Danielle Frost; Bessie Meechoovet; Tong Wang; Stephen Gately; Marco Giorgetti; Irina Shcherbakova; Travis Dunckley

2011-01-01

171

Multiple disordered loops function in corepressor-induced dimerization of the biotin repressor.  

PubMed

Cooperative association of the Escherichia coli biotin repressor with the biotin operator is allosterically activated by binding of the corepressor, bio-5'-AMP. The corepressor function of the adenylate is due, in part, to its ability to induce repressor dimerization. Since a high-resolution structure of only the apo or unliganded repressor is currently available, the location of the dimerization interface on the protein structure is not known. Here, five mutants in the corepressor-binding domain of the repressor have been analyzed with respect to their DNA-binding and self-assembly properties. Results of these studies reveal that four of the mutant proteins exhibit defects in DNA binding. These same proteins are compromised in self-assembly. Furthermore, in the three-dimensional structure of the apo protein the mutations all lie in partially disordered surface loops, one of which is known to participate directly in corepressor binding. These results suggest that multiple disordered surface loops function in the corepressor-induced dimerization required for sequence-specific DNA binding by the biotin repressor. PMID:11124029

Kwon, K; Streaker, E D; Ruparelia, S; Beckett, D

2000-12-15

172

Unresponsiveness to psychosocial stress in a subgroup of autistic-like children, multiple complex developmental disorder.  

PubMed

In this study, we tried to replicate the finding of a diminished cortisol response to stress in autistic-like patients in a more homogenous Multiple Complex Developmental Disorder (MCDD) group. MCDD forms a distinct group within the autistic-like disorders, characterized by impaired regulation of anxiety and affective state, impaired social behavior/sensitivity, and thought disorder. A number of MCDD children develop schizophrenia in adult life. Responses to a psychosocial stressor, consisting of speaking in public while recorded on video, were measured in 10 MCDD children and 12 healthy control children. The public speaking test was imbedded in a two-hour test session, and compared to a control test session. Hypothalamic-pituitary-adrenal (HPA) responses were measured on salivary cortisol at about 20-minute intervals. Heart rate was measured continuously. Delta AUC's were computed for both heart rate (dAUCHR) and salivary cortisol (dAUCCORT), as a measure of response to the test.The public speaking task resulted in significant responses in heart rate and salivary cortisol in healthy control children, but not in MCDD children. dAUCHR was 3.28+/-2.37 in healthy control children, but -0.09+/-1.73 in MCDD children (t=3.31, P<0.01). dAUCCORT was 3.22+/-3.16 in healthy control children, but 0. 17+/-1.74 in MCDD children (t=2.72, P<0.05).The impaired responses to psychosocial stress found in MCDD children may be the result of their limited abilities to react adequately to their (social) environment. The same impairment in stress processing has been found in schizophrenia, and might be a factor in the vulnerability of these MCDD children to develop schizophrenia. PMID:10996471

Jansen, L M; Gispen-de Wied, C C; Van der Gaag, R J; ten Hove, F; Willemsen-Swinkels, S W; Harteveld, E; Van Engeland, H

2000-11-01

173

Response properties of III-V dilute magnetic semiconductors including disorder, dynamical electron-electron interactions, and band structure effects  

NASA Astrophysics Data System (ADS)

A theory of the electronic response in spin and charge disordered media is developed with the particular aim to describe III-V dilute magnetic semiconductors like Ga1-xMnxAs. The theory combines a detailed k·p description of the valence-band, in which the itinerant carriers are assumed to reside, with first-principles calculations of disorder contributions using an equation-of-motion approach for the current response function. A fully dynamic treatment of electron-electron interaction is achieved by means of time-dependent density-functional theory. It is found that collective excitations within the valence-band significantly increase the carrier relaxation rate by providing effective channels for momentum relaxation. This modification of the relaxation rate, however, has only a minor impact on the infrared optical conductivity in Ga1-xMnxAs, which is mostly determined by the details of the valence-band structure and found to be in agreement with experiment.

Kyrychenko, F. V.; Ullrich, C. A.

2011-05-01

174

Achlorhydria, parietal cell hyperplasia, and multiple gastric carcinoids: a new disorder.  

PubMed

We describe a 54-year-old woman who had multiple gastric carcinoid tumors arising in the setting of marked hypergastrinemia associated with a lack of acid production by hypertrophic parietal cells. The serum gastrin level was 1,400 pg/mL, and investigation revealed no evidence for either of the recognized causes for hypergastrinemia-associated carcinoids, autoimmune gastritis, and Zollinger-Ellision syndrome. Partial gastrectomy was performed. Pathologic examination showed multiple intramucosal and invasive carcinoid tumors of the body and fundus in a background of marked ECL cell hyperplasia. There were no gastric or duodenal ulcerations. One perigastric lymph node was metastatically involved. The oxyntic mucosa showed marked hyperplasia and hypertrophy of the parietal cells. Some of these cells were vacuolated, and many displayed protrusions of apical cytoplasm into dilated oxyntic glands filled with inspissated eosinophilic material. Similar findings have occurred in 1 other patient, strongly indicating that the clinicopathologic alterations in the 2 cases are not random but, on the contrary, represent a very rare disorder of gastric carcinoids associated with an intrinsic acid secretion abnormality of the parietal cells. PMID:15958864

Abraham, Susan C; Carney, J Aidan; Ooi, Akishi; Choti, Michael A; Argani, Pedram

2005-07-01

175

Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis.  

PubMed

Neurological manifestations of gastrointestinal disorders are described, with particular reference to those resembling multiple sclerosis (MS) on clinical or MRI grounds. Patients with celiac disease can present cerebellar ataxia, progressive myoclonic ataxia, myelopathy, or cerebral, brainstem and peripheral nerve involvement. Antigliadin antibodies can be found in subjects with neurological dysfunction of unknown cause, particularly in sporadic cerebellar ataxia ("gluten ataxia"). Patients with Whipple's disease can develop mental and psychiatric changes, supranuclear gaze palsy, upper motoneuron signs, hypothalamic dysfunction, cranial nerve abnormalities, seizures, ataxia, myorhythmia and sensory deficits. Neurological manifestations can complicate inflammatory bowel disease (e.g. ulcerative colitis and Crohn's disease) due to vascular or vasculitic mechanisms. Cases with both Crohn's disease and MS or cerebral vasculitis are described. Epilepsy, chronic inflammatory polyneuropathy, muscle involvement and myasthenia gravis are also reported. The central nervous system can be affected in patients with hepatitis C virus (HCV) infection because of vasculitis associated with HCV-related cryoglobulinemia. Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a disease caused by multiple deletions of mitochondrial DNA. It is characterized by peripheral neuropathy, ophthalmoplegia, deafness, leukoencephalopathy, and gastrointestinal symptoms due to visceral neuropathy. Neurological manifestations can be the consequence of vitamin B1, nicotinamide, vitamin B12, vitamin D, or vitamin E deficiency and from nutritional deficiency states following gastric surgery. PMID:11794474

Ghezzi, A; Zaffaroni, M

2001-11-01

176

Potential for Early-Life Immune Insult Including Developmental Immunotoxicity in Autism and Autism Spectrum Disorders: Focus on Critical Windows of Immune Vulnerability  

Microsoft Academic Search

Early-life immune insults (ELII) including xenobiotic-induced developmental immunotoxicity (DIT) are important factors in childhood and adult chronic diseases. However, prenatal and perinatal environmentally induced immune alterations have yet to be considered in depth in the context of autism and autism spectrum disorders (ASDs). Numerous factors produce early-life-induced immune dysfunction in offspring, including exposure to xenobiotics, maternal infections, and other prenatal–neonatal

Rodney R. Dietert; Janice M. Dietert

2008-01-01

177

The Multiple, Distinct Ways that Personality Contributes to Alcohol Use Disorders  

PubMed Central

There is little question of whether personality is associated with problematic alcohol involvement (such as alcohol use disorders; AUDs); it clearly is. However, the question remains: how or why is personality related to risky drinking and AUDs? To address this question, theoretical models have been posited regarding the causal effects of personality on alcohol use and related problems. In this article, several of these models are summarized and reviewed. Future research directions are discussed, including possible frameworks that serve to integrate various models of the personality-AUD relation.

Littlefield, Andrew K.; Sher, Kenneth J.

2010-01-01

178

The Multiple, Distinct Ways that Personality Contributes to Alcohol Use Disorders.  

PubMed

There is little question of whether personality is associated with problematic alcohol involvement (such as alcohol use disorders; AUDs); it clearly is. However, the question remains: how or why is personality related to risky drinking and AUDs? To address this question, theoretical models have been posited regarding the causal effects of personality on alcohol use and related problems. In this article, several of these models are summarized and reviewed. Future research directions are discussed, including possible frameworks that serve to integrate various models of the personality-AUD relation. PMID:21170162

Littlefield, Andrew K; Sher, Kenneth J

2010-09-01

179

Depersonalization Disorder  

MedlinePLUS

... re in your mid- to late teens or early adulthood. Depersonalization disorder is rare in children and older adults. You have panic disorder, depression, schizophrenia, post-traumatic stress disorder (PTSD) or multiple personality disorder. Complications Episodes of ...

180

Responses to panic induction procedures in subjects with multiple chemical sensitivity/idiopathic environmental intolerance: understanding the relationship with panic disorder.  

PubMed

Idiopathic environmental intolerance (IEI), also known as multiple chemical sensitivity, is a clinical description for a cluster of symptoms of unknown etiology that have been attributed by patients to multiple environmental exposures when other medical explanations have been excluded. Because allergy has not been clearly demonstrated and current toxicological paradigms for exposure-symptom relationships do not readily accommodate IEI, psychogenic theories have been the focus of a number of investigations. A significantly higher lifetime prevalence of major depression, mood disorders, anxiety disorders, and somatization disorder has been reported among patients with environmental illness compared with that in controls. Symptoms often include anxiety, lightheadedness, impaired mentation, poor coordination, breathlessness (without wheezing), tremor, and abdominal discomfort. Responses to intravenous sodium lactate challenge or single-breath inhalation of 35% carbon dioxide versus a similar breath inhalation of clean air have shown a greater frequency of panic responses in subjects with IEI than in control subjects, although such responses did not occur in all subjects. Preliminary genetic findings suggest an increased frequency of a common genotype with panic disorder patients. The panic responses in a significant proportion of IEI patients opens a therapeutic window of opportunity. Patients in whom panic responses may at least be a contributing factor to their symptoms might be responsive to intervention with psychotherapy to enable their desensitization or deconditioning of responses to odors and other triggers, and/or may be helped by anxiolytic medications, relaxation training, and counseling for stress management. PMID:12194904

Tarlo, Susan M; Poonai, Naveen; Binkley, Karen; Antony, Martin M; Swinson, Richard P

2002-08-01

181

Responses to panic induction procedures in subjects with multiple chemical sensitivity/idiopathic environmental intolerance: understanding the relationship with panic disorder.  

PubMed Central

Idiopathic environmental intolerance (IEI), also known as multiple chemical sensitivity, is a clinical description for a cluster of symptoms of unknown etiology that have been attributed by patients to multiple environmental exposures when other medical explanations have been excluded. Because allergy has not been clearly demonstrated and current toxicological paradigms for exposure-symptom relationships do not readily accommodate IEI, psychogenic theories have been the focus of a number of investigations. A significantly higher lifetime prevalence of major depression, mood disorders, anxiety disorders, and somatization disorder has been reported among patients with environmental illness compared with that in controls. Symptoms often include anxiety, lightheadedness, impaired mentation, poor coordination, breathlessness (without wheezing), tremor, and abdominal discomfort. Responses to intravenous sodium lactate challenge or single-breath inhalation of 35% carbon dioxide versus a similar breath inhalation of clean air have shown a greater frequency of panic responses in subjects with IEI than in control subjects, although such responses did not occur in all subjects. Preliminary genetic findings suggest an increased frequency of a common genotype with panic disorder patients. The panic responses in a significant proportion of IEI patients opens a therapeutic window of opportunity. Patients in whom panic responses may at least be a contributing factor to their symptoms might be responsive to intervention with psychotherapy to enable their desensitization or deconditioning of responses to odors and other triggers, and/or may be helped by anxiolytic medications, relaxation training, and counseling for stress management.

Tarlo, Susan M; Poonai, Naveen; Binkley, Karen; Antony, Martin M; Swinson, Richard P

2002-01-01

182

Multiple Channel Exposure Therapy: Combining Cognitive-Behavioral Therapies for the Treatment of Posttraumatic Stress Disorder with Panic Attacks  

ERIC Educational Resources Information Center

|A large proportion of patients who present for treatment of posttraumatic stress disorder (PTSD) experience comorbid panic attacks, yet it is unclear to what extent currently available PTSD treatment programs address this problem. Here we describe a newly developed treatment, multiple-channel exposure therapy (M-CET), for comorbid PTSD and panic…

Falsetti, Sherry A.; Resnick, Heidi S.; Davis, Joanne

2005-01-01

183

International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders  

Microsoft Academic Search

The serum immunoglobulin-free light chain (FLC) assay measures levels of free ? and ? immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields high

A Dispenzieri; R Kyle; G Merlini; J S Miguel; H Ludwig; R Hajek; A Palumbo; S Jagannath; J Blade; S Lonial; M Dimopoulos; R Comenzo; H Einsele; B Barlogie; K Anderson; M Gertz; J L Harousseau; M Attal; P Tosi; P Sonneveld; M Boccadoro; G Morgan; P Richardson; O Sezer; M V Mateos; M Cavo; D Joshua; I Turesson; W Chen; K Shimizu; R Powles; S V Rajkumar; B G M Durie

2009-01-01

184

Efficient Treatment of Neurogenic Bladder Disorders in Multiple Sclerosis with Initial Intermittent Catheterization and Ultrasound-Controlled Training  

Microsoft Academic Search

Out of 350 multiple sclerosis (MS) patients, 197 had residual urine (RU), on average 113 ml on admission. Treatment with initial intermittent catheterisation and bladder training normalized the neurogenic bladder disorders (NBD) in most patients; the RU was 28 ml on average at discharge. Continence improved with the reduction of RU. Even in those 37 patients with a RU of

H. H. Kornhuber; A. Schütz

1990-01-01

185

Splitting Phenomena from a Viewpoint of Experiencing Time: Spectrum from Multiple Personality and Hysteria to Borderline Personality Disorder  

Microsoft Academic Search

Splitting is defined from a viewpoint of experiencing time as an ‘episodic loss or sudden shift of experiencing time induced by two opposing representational groups’. According to this definition splitting phenomena are examined in four cases arranged on a spectrum from multiple personality and hysteria to borderline personality disorder (BPD). The degree of splitting was most prominent in BPD. In

Hideshi Shoda

1993-01-01

186

Study Modules for Calculus-Based General Physics. [Includes Modules 3-5: Planar Motion; Newton's Laws; and Vector Multiplication].  

ERIC Educational Resources Information Center

|This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

Fuller, Robert G., Ed.; And Others

187

Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data.  

PubMed

Multiple myeloma causes major morbidity resulting from osteolytic lesions that can be detected by metastatic bone surveys. Magnetic resonance imaging and positron emission tomography can detect bone marrow focal lesions long before development of osteolytic lesions. Using data from patients enrolled in Total Therapy 3 for newly diagnosed myeloma (n=303), we analyzed associations of these imaging techniques with baseline standard laboratory variables assessed before initiating treatment. Of 270 patients with complete imaging data, 245 also had gene expression profiling data. Osteolytic lesions detected on metastatic bone surveys correlated with focal lesions detected by magnetic resonance imaging and positron emission tomography, although, in two-way comparisons, focal lesion counts based on both magnetic resonance imaging and positron emission tomography tended to be greater than those based on metastatic bone survey. Higher numbers of focal lesions detected by magnetic resonance imaging and positron emission tomography were positively linked to high serum concentrations of C-reactive protein, gene-expression-profiling-defined high risk, and the proliferation molecular subgroup. Positron emission tomography focal lesion maximum standardized unit values were significantly correlated with gene-expression-profiling-defined high risk and higher numbers of focal lesions detected by positron emission tomography. Interestingly, four genes associated with high-risk disease (related to cell cycle and metabolism) were linked to counts of focal lesions detected by magnetic resonance imaging and positron emission tomography. Collectively, our results demonstrate significant associations of all three imaging techniques with tumor burden and, especially, disease aggressiveness captured by gene-expression-profiling-risk designation. (Clinicaltrials.gov identifier: NCT00081939). PMID:22733020

Waheed, Sarah; Mitchell, Alan; Usmani, Saad; Epstein, Joshua; Yaccoby, Shmuel; Nair, Bijay; van Hemert, Rudy; Angtuaco, Edgardo; Brown, Tracy; Bartel, Twyla; McDonald, James; Anaissie, Elias; van Rhee, Frits; Crowley, John; Barlogie, Bart

2012-06-24

188

Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data  

PubMed Central

Multiple myeloma causes major morbidity resulting from osteolytic lesions that can be detected by metastatic bone surveys. Magnetic resonance imaging and positron emission tomography can detect bone marrow focal lesions long before development of osteolytic lesions. Using data from patients enrolled in Total Therapy 3 for newly diagnosed myeloma (n=303), we analyzed associations of these imaging techniques with baseline standard laboratory variables assessed before initiating treatment. Of 270 patients with complete imaging data, 245 also had gene expression profiling data. Osteolytic lesions detected on metastatic bone surveys correlated with focal lesions detected by magnetic resonance imaging and positron emission tomography, although, in two-way comparisons, focal lesion counts based on both magnetic resonance imaging and positron emission tomography tended to be greater than those based on metastatic bone survey. Higher numbers of focal lesions detected by magnetic resonance imaging and positron emission tomography were positively linked to high serum concentrations of C-reactive protein, gene-expression-profiling–defined high risk, and the proliferation molecular subgroup. Positron emission tomography focal lesion maximum standardized unit values were significantly correlated with gene-expression-profiling–defined high risk and higher numbers of focal lesions detected by positron emission tomography. Interestingly, four genes associated with high-risk disease (related to cell cycle and metabolism) were linked to counts of focal lesions detected by magnetic resonance imaging and positron emission tomography. Collectively, our results demonstrate significant associations of all three imaging techniques with tumor burden and, especially, disease aggressiveness captured by gene-expression-profiling–risk designation. (Clinicaltrials.gov identifier: NCT00081939)

Waheed, Sarah; Mitchell, Alan; Usmani, Saad; Epstein, Joshua; Yaccoby, Shmuel; Nair, Bijay; van Hemert, Rudy; Angtuaco, Edgardo; Brown, Tracy; Bartel, Twyla; McDonald, James; Anaissie, Elias; van Rhee, Frits; Crowley, John; Barlogie, Bart

2013-01-01

189

Optical observations of 23 distant Jupiter Family Comets, including 36P\\/Whipple at multiple phase angles  

Microsoft Academic Search

We present photometry on 23 Jupiter Family Comets (JFCs) observed at large heliocentric distance, primarily using the 2.5-m Isaac Newton Telescope (INT). Snapshot images were taken of 17 comets, of which five were not detected, three were active and nine were unresolved and apparently inactive. These include 103P\\/Hartley 2, the target of the NASA Deep Impact extended mission, EPOXI. For

Colin Snodgrass; S. C. Lowry; Alan Fitzsimmons

2008-01-01

190

Lower urinary tract and bowel disorders and multiple sclerosis: role of sacral neuromodulation: a preliminary report.  

PubMed

Objective.? In the present study we wanted to determine whether sacral neuromodulation benefits patients with bladder and bowel symptoms caused by multiple sclerosis (MS). Methods.? At our Institute, five patients with MS underwent unilateral implantation of a sacral neuromodulation system, InterStim (Medtronic Inc., Minneapolis, Minnesota, USA), between April 2001 and June 2002; the mean follow-up was 30.4 months (range 24-38). The following parameters were evaluated before and after implant of the neurostimulator device: number of daily voidings, number of incontinent episodes, residual urine, Wexner score, quality of life (QoL), and psychological impact. Results.? There was an overall 81.4% decrease of urgency and frequency with a significant decrease in the number of upper urinary tract infections and fever; there was a slight improvement in bowel function; there was an overall 51.8% improvement in the QoL and a discernible improvement emotional well-being. Conclusions.? Unilateral chronic sacral neuromodulation can be a valuable treatment for neurogenic bladder and bowel disorders associated with MS. PMID:22151487

Minardi, Daniele; Muzzonigro, Giovanni

2005-07-01

191

Mutation Analysis of NR5A1 Encoding Steroidogenic Factor 1 in 77 Patients with 46, XY Disorders of Sex Development (DSD) Including Hypospadias  

Microsoft Academic Search

BackgroundMutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias.Methodology\\/Principal FindingsWe evaluated the frequency of NR5A1 gene mutations in a large series of patients presenting with 46,XY DSD and hypospadias. Based on their clinical presentation 77 patients were classified either

Slimane Allali; Jean-Baptiste Muller; Raja Brauner; Diana Lourenço; Radia Boudjenah; Vasiliki Karageorgou; Christine Trivin; Henri Lottmann; Stephen Lortat-Jacob; Claire Nihoul-Fékété; Olivier de Dreuzy; Ken McElreavey; Anu Bashamboo; Joerg Gromoll

2011-01-01

192

Optical observations of 23 distant Jupiter Family Comets, including 36P/Whipple at multiple phase angles  

NASA Astrophysics Data System (ADS)

We present photometry on 23 Jupiter Family Comets (JFCs) observed at large heliocentric distance, primarily using the 2.5-m Isaac Newton Telescope (INT). Snapshot images were taken of 17 comets, of which five were not detected, three were active and nine were unresolved and apparently inactive. These include 103P/Hartley 2, the target of the NASA Deep Impact extended mission, EPOXI. For six comets we obtained time-series photometry and use this to constrain the shape and rotation period of these nuclei. The data are not of sufficient quantity or quality to measure precise rotation periods, but the time-series do allow us to measure accurate effective radii and surface colours. Of the comets observed over an extended period, 40P/Väisälä 1, 47P/Ashbrook-Jackson and P/2004 H2 (Larsen) showed faint activity which limited the study of the nucleus. Light curves for 94P/Russell 4 and 121P/Shoemaker-Holt 2 reveal rotation periods of around 33 and 10h, respectively, although in both cases these are not unique solutions. 94P was observed to have a large range in magnitudes implying that it is one of the most elongated nuclei known, with an axial ratio a/b >= 3. 36P/Whipple was observed at five different epochs, with the INT and ESO's 3.6-m NTT, primarily in an attempt to confirm the preliminary short rotation period apparent in the first data set. The combined data set shows that the rotation period is actually longer than 24h. A measurement of the phase function of 36P's nucleus gives a relatively steep ? = 0.060 +/- 0.019. Finally, we discuss the distribution of surface colours observed in JFC nuclei, and show that it is possible to trace the evolution of colours from the Kuiper Belt Object (KBO) population to the JFC population by applying a `dereddening' function to the KBO colour distribution. Based on observations collected at the European Southern Observatory, Chile (proposals: ESO Nos 74.C-0125, 278.C-5040), and at the Isaac Newton Group of telescopes on La Palma (proposals: I/2005A/11, I/2006A/7). E-mail: csnodgra@eso.org ‡ Present address: NASA Jet Propulsion Laboratory, Science Division, 4800 Oak Grove Drive, Pasadena, CA 91101, USA.

Snodgrass, C.; Lowry, S. C.; Fitzsimmons, A.

2008-04-01

193

Extended X-ray absorption fine structure (EXAFS) analysis of disorder and multiple-scattering in complex crystalline solids  

SciTech Connect

Quantitative determination of local atomic structure in complex materials using extended X-ray absorption fine structure (EXAFS) analysis was tested on eight inorganic compounds of known structure, including natural and synthetic crystalline solids, at ambient conditions. Our aim was to test the accuracy of experimental and theoretical EXAFS standard functions in determining the number of backscattering atoms (N) at a distance (R) beyond the ligating shell of the central absorber atom where effects from disorder, multiple-scattering, and overlapping shells of atoms may significantly influence the EXAFS spectra. These compounds have complicated structures compared to metals and contain Fe, Co, or Ni as the central absorbing atom and mixtures of second-row (C,O,F), third-row (Si, Cl), and fourth-row (Ca, Fe, Co, Ni) atoms as backscatters. Comparison of results using both experimental phase shift and amplitude functions (derived from the EXAFS spectra of the compounds) and those calculated from ab initio theory (using the computer code FEFF 5) shows that interatomic distances for single-scattering paths among metal atoms can be determined to within 0.02 A of values determined independently by X-ray diffraction up to a distance of 4 A from the central absorber by either method. 25 refs., 7 figs., 6 tabs.

O'Day, P.A.; Brown, G.E. Jr. (Stanford Univ., CA (United States)); Rehr, J.J.; Zabinsky, S.I. (Univ. of Washington, Seattle, WA (United States))

1994-04-06

194

Self-management in neurological disorders: systematic review of the literature and potential interventions in multiple sclerosis care.  

PubMed

Our objective was to review the current body of evidence supporting the efficacy of self-management programs in individuals with multiple sclerosis (MS) and other chronic neurological conditions. We reviewed published literature using standardized search terms; examined self-management interventions in a variety of chronic neurological disorders, including MS; and classified studies using the evidence classification established by the American Academy of Neurology. We reviewed 527 abstracts, of which 39 met our inclusion criteria for evaluation. Of the 39 studies, 3 provided class I evidence assessing the efficacy of self-management interventions: a randomized controlled trial of a telephone counseling program for health promotion in MS, a home-based exercise program for reducing falls in people with Parkinson disease, and the comparison of a fitness center program versus a home-based exercise program for people with traumatic brain injury. The remaining studies provided additional support for self-management interventions with a lesser degree of methodologic rigor (class II, class III, or class IV evidence). We concluded that self-management strategies are applicable to chronic neurological diseases, but a need exists for more rigorous studies in this area. We provide recommendations for future intervention study methodologies with a specific emphasis on MS care. PMID:22234713

Rae-Grant, Alex D; Turner, Aaron P; Sloan, Alicia; Miller, Deborah; Hunziker, James; Haselkorn, Jodie K

2011-01-01

195

Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis.  

PubMed

The psychopathological status of 25 inpatients suffering from clinically definite multiple sclerosis (MS) according to Poser criteria was assessed by using standardized methods (Structured Clinical Interview for DSM-III-R, Inpatient Multidimensional Psychiatric Scale, Hamilton and Montgomery-Asberg Depression Rating Scales and the Structured Interview for the Diagnosis of Alzheimer Dementia and Dementias of other Aetiology (SIDAM). Magnetic resonance (MRT) (0.5 T; T2-weighted sequence) of the brain was analysed by measuring the ventricular brain ration (VBR), the area of the corpus callosum (CC) and the extension of hyperintense lesions of the brainstem, the temporal lobes and the brain at all. Six of 25 (24%) of these moderately disabled patients (mean Extended Disability Score (EDSS) 3.3) were diagnosed to suffer from depressive mood disorder (major depression or dysthymia); 2 were demented. In correlation analysis, depression was unrelated to age, gender, duration of illness, status of disability (EDSS) or the results of cognitive assessment. No relationship between the depression scores and the different MRT measures could be identified. The presence or absence of gadolinium enhancement was also uncorrelated to depressive symptoms. Fatigue as measured by the Fatigue Severity Scale was unrelated to depression or subcortical brain atrophy (increased VBR) but significantly correlated to the area of hyperintense MRT changes in brainstem and midbrain. Cognitive impairment (decreased SIDAM scores) was correlated to the total area of hyperintense MRT changes of the brain parenchyma. The type of clinical course (relapsing-remitting vs chronic progredient) was not found to influence the affective or cognitive state in our MS patient's sample. PMID:8178661

Möller, A; Wiedemann, G; Rohde, U; Backmund, H; Sonntag, A

1994-02-01

196

P450 Oxidoreductase Deficiency: A Disorder of Steroidogenesis with Multiple Clinical Manifestations  

NSDL National Science Digital Library

Cytochrome P450 enzymes catalyze the biosynthesis of steroid hormones and metabolize drugs. There are seven human type I P450 enzymes in mitochondria and 50 type II enzymes in endoplasmic reticulum. Type II enzymes, including both drug-metabolizing and some steroidogenic enzymes, require electron donation from a two-flavin protein, P450 oxidoreductase (POR). Although knockout of the POR gene causes embryonic lethality in mice, we discovered human POR deficiency as a disorder of steroidogenesis associated with the Antley-Bixler skeletal malformation syndrome and found mild POR mutations in phenotypically normal adults with infertility. Assay results of mutant forms of POR using the traditional but nonphysiologic assay (reduction of cytochrome c) did not correlate with patient phenotypes; assays based on the 17,20 lyase activity of P450c17 (CYP17) correlated with clinical phenotypes. The POR sequence in 842 normal individuals revealed many polymorphisms; amino acid sequence variant A503V is encoded by ~28% of human alleles. POR A503V has about 60% of wild-type activity in assays with CYP17, CYP2D6, and CYP3A4, but nearly wild-type activity with P450c21, CYP1A2, and CYP2C19. Activity of a particular POR variant with one P450 enzyme will not predict its activity with another P450 enzyme: Each POR-P450 combination must be studied individually. Human POR transcription, initiated from an untranslated exon, is regulated by Smad3/4, thyroid receptors, and the transcription factor AP-2. A promoter polymorphism reduces transcription to 60% in liver cells and to 35% in adrenal cells. POR deficiency is a newly described disorder of steroidogenesis, and POR variants may account for some genetic variation in drug metabolism.

Walter L. Miller (San Francisco;University of California REV)

2012-10-23

197

P450 oxidoreductase deficiency: a disorder of steroidogenesis with multiple clinical manifestations.  

PubMed

Cytochrome P450 enzymes catalyze the biosynthesis of steroid hormones and metabolize drugs. There are seven human type I P450 enzymes in mitochondria and 50 type II enzymes in endoplasmic reticulum. Type II enzymes, including both drug-metabolizing and some steroidogenic enzymes, require electron donation from a two-flavin protein, P450 oxidoreductase (POR). Although knockout of the POR gene causes embryonic lethality in mice, we discovered human POR deficiency as a disorder of steroidogenesis associated with the Antley-Bixler skeletal malformation syndrome and found mild POR mutations in phenotypically normal adults with infertility. Assay results of mutant forms of POR using the traditional but nonphysiologic assay (reduction of cytochrome c) did not correlate with patient phenotypes; assays based on the 17,20 lyase activity of P450c17 (CYP17) correlated with clinical phenotypes. The POR sequence in 842 normal individuals revealed many polymorphisms; amino acid sequence variant A503V is encoded by ~28% of human alleles. POR A503V has about 60% of wild-type activity in assays with CYP17, CYP2D6, and CYP3A4, but nearly wild-type activity with P450c21, CYP1A2, and CYP2C19. Activity of a particular POR variant with one P450 enzyme will not predict its activity with another P450 enzyme: Each POR-P450 combination must be studied individually. Human POR transcription, initiated from an untranslated exon, is regulated by Smad3/4, thyroid receptors, and the transcription factor AP-2. A promoter polymorphism reduces transcription to 60% in liver cells and to 35% in adrenal cells. POR deficiency is a newly described disorder of steroidogenesis, and POR variants may account for some genetic variation in drug metabolism. PMID:23092891

Miller, Walter L

2012-10-23

198

Similar or Disparate Brain Patterns? The Intra-Personal EEG Variability of Three Women with Multiple Personality Disorder  

Microsoft Academic Search

Quantitative EEG was used to assess the intra-personal variability of brain electrical activity for 3 women diagnosed with Multiple Personality Disorder (MPD). Two separate control groups (within-subject and between-subject) were used to test the hypothesis that the intra-personal EEG variability between 2 alters would be less than the interpersonal EEG variability between 2 controls, and similar to the intra-personal EEG

A. R. Lapointe; J. W. Crayton; R. deVito; C. G. Fichtner; L. M. Konopka

2006-01-01

199

An Ontology for the Integration of Multiple Genetic Disorder Data Sources  

Microsoft Academic Search

As a huge amount of gene disorder information is available on the Internet, there is an increasing requirement to integrate these data sources. The integration of gene disorder data sources provides an important tool in the research of life science, therapeutics, and genetic disease prevention and inhibition. The key challenge of such integration is how to deal with semantic heterogeneity

P. Gong; W. Qu; D. D. Feng

2005-01-01

200

Immediate-Release Methylphenidate for ADHD in Children With Comorbid Chronic Multiple Tic Disorder  

Microsoft Academic Search

ObjectiveTo examine the safety and efficacy of immediate-release methylphenidate (MPH-IR) for the treatment of attention-deficit\\/hyperactivity disorder (ADHD) in children (ages 6-12 years) with Tourette's syndrome (96%) or chronic motor tic disorder (4%).

KENNETH D. GADOW; JEFFREY SVERD; EDITH E. NOLAN; JOYCE SPRAFKIN; JAYNE SCHNEIDER

2007-01-01

201

Commentary: Differentiated Measures of Temperament and Multiple Pathways to Childhood Disorders  

ERIC Educational Resources Information Center

Provided is a commentary on articles written for a special section on temperament and childhood disorders. Temperament's contributions to the development of childhood disorders are considered both generally and specifically. Questions are raised about the use of terminology in the field, particularly the term difficult. Differentiation of outcomes…

Rothbart, Mary K.

2004-01-01

202

Cost-effectiveness of collaborative care including PST and an antidepressant treatment algorithm for the treatment of major depressive disorder in primary care; a randomised clinical trial  

Microsoft Academic Search

BACKGROUND: Depressive disorder is currently one of the most burdensome disorders worldwide. Evidence-based treatments for depressive disorder are already available, but these are used insufficiently, and with less positive results than possible. Earlier research in the USA has shown good results in the treatment of depressive disorder based on a collaborative care approach with Problem Solving Treatment and an antidepressant

Marjoliek A IJff; Klaas ML Huijbregts; Harm WJ van Marwijk; Aartjan TF Beekman; Leona Hakkaart-van Roijen; Frans F Rutten; Jürgen Unützer; Christina M van der Feltz-Cornelis

2007-01-01

203

Rapid Switching of Mood in Families With Multiple Cases of Bipolar Disorder  

Microsoft Academic Search

Background:Heterogeneitywithinthediagnosticcon- structofbipolardisorderismostlikelyanobstacletodis- covering its causes. Phenomena in the bipolar spec- trum,includingrapidcycling,cyclothymia,andaffective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena. Methods:Weperformedacase-controlstudy,usingdi- agnostic data from a multisite bipolar disorder linkage study, to explore clinical and demographic factors po- tentially related to rapid switching in bipolar disorder. Participantswere18yearsorolderandmembersofafam- ily in

Dean F. MacKinnon; Peter P. Zandi; Elliot Gershon; John I. Nurnberger; Theodore Reich; J. Raymond DePaulo

2003-01-01

204

The multiple dimensions of the social anxiety spectrum in mood disorders.  

PubMed

Major depressive disorder and bipolar spectrum disorders are debilitating conditions associated with severe impairment. The presence of co-occurring social phobia can make the clinical course of these disorders even more challenging. To better understand the nature of social anxiety in the context of ongoing mood disorders, we report the results of exploratory factor analyses of the Social Phobia Spectrum Self-Report Instrument (SHY), a 162-item measure designed to capture the full spectrum of manifestations and features associated with social anxiety experienced across the lifespan. We examined data from 359 adult outpatients diagnosed with major depressive disorder and 403 outpatients diagnosed with a bipolar spectrum disorder. The measure was divided into its two components: the SHY-General (SHY-G), reflecting general social anxiety features, and the SHY-Specific (SHY-S), reflecting anxiety in specific situations. Exploratory factor analyses were conducted for each using tetrachoric correlation matrices and an unweighted least squares estimator. Item invariance was evaluated for important patient subgroups. Five factors were identified for the SHY-G, representing general features of social anxiety: Fear of Social Disapproval, Childhood Social Anxiety, Somatic Social Anxiety, Excessive Agreeableness, and Behavioral Submission. Seven specific-situation factors were identified from the SHY-S: Writing in Public, Dating, Public Speaking, Eating in Public, Shopping Fears, Using Public Restrooms, and Unstructured Social Interactions. The identified dimensions provide clinically valuable information about the nature of the social fears experienced by individuals diagnosed with mood disorders and could help guide the development of tailored treatment strategies for individuals with co-occurring mood disorders and social anxiety. PMID:22771202

Fournier, Jay C; Cyranowski, Jill M; Rucci, Paola; Cassano, Giovanni B; Frank, Ellen

2012-07-05

205

Multiple scaled disorder in the photonic structure of Morpho rhetenor butterfly  

NASA Astrophysics Data System (ADS)

The iridescence of Morpho rhetenor butterfly is known to result from a photonic structure on wing scales, where multilayer interference and grating diffraction occur simultaneously. We characterize the disorder at the photonic structure length scale and at the butterfly scale. We measure the scattering pattern of the wing. Through RCWA and 1st Born approximation models, we link the different disorders to different features in the scattering patterns.

Boulenguez, J.; Berthier, S.; Leroy, F.

2012-03-01

206

A multiple-risk interaction model: effects of temperament and divorce on psychiatric disorders in children.  

PubMed

Effects of family status on the trajectory of problematic temperament-adjustment at 1 and 10 years of age and associated psychiatric disturbance 8 years later were examined in an epidemiological sample of 648 children. After adjusting for predivorce temperament-adjustment and background factors, logistic regression yielded independent effects of single custodial mother (SCM) family status for increased risk of disruptive and anxiety disorders, and of stepfamily status for increased risk of disruptive disorders. Increased risk of psychiatric disorders was more pervasive for SCM family boys versus intact family boys than for SCM family girls versus intact family girls, however only significantly more so for depression. No significant sex interaction was observed for stepfamily status. When girls and boys were treated independently, patterns of family status and outcomes of internalizing disorders varied. In stepfamilies, an elevated risk of depression and anxiety disorders was observed in girls but not boys, whereas in SCM families an elevated risk of depression was observed in boys but not girls. Within each family status group there was support for an altered risk of later psychiatric disorders given specific problematic predivorce temperament-adjustment characteristics. Implications for future research and treatment are discussed. PMID:8743241

Kasen, S; Cohen, P; Brook, J S; Hartmark, C

1996-04-01

207

Multiplicity.  

National Technical Information Service (NTIS)

In federal practice, the double jeopardy protection against multiple punishment for the same offense has been described as 'one of the least understood' and 'most frequently litigated' issues. In military practice, the protection operates under the nom-de...

T. L. Herrington

1991-01-01

208

Report from the European Myeloma Network on interphase FISH in multiple myeloma and related disorders.  

PubMed

The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report was discussed at the EHA Myeloma Scientific Working Group Meeting 2010. During the quality control exercise, there was acceptable agreement on more than 1,000 tests. The conclusions from the exercise were that the primary clinical applications for FISH analysis were for newly diagnosed cases of MM or frank relapse cases. A range of technical recommendations included: 1) material should be part of the first draw of the aspirate; 2) samples should be sent at suitable times to allow for the lengthy processing procedure; 3) most importantly, PCs must be purified or specifically identified; 4) positive cut-off levels should be relatively conservative: 10% for fusion or break-apart probes, 20% for numerical abnormalities; 5) informative probes should be combined to best effect; 6) in specialist laboratories, a single experienced analyst is considered adequate; 7) at least 100 PC should be scored; 8) essential abnormalities to test for are t(4;14), t(14;16) and 17p13 deletions; 9) suitable commercial probes should be available for clinically relevant abnormalities; 10) the clinical report should be expressed clearly and must state the percentage of PC involved and the method used for identification; 11) a retrospective European based FISH data bank linked to clinical data should be generated; and 12) prospective analysis should be centralized for upcoming trials based on the recommendations made. The European Myeloma Network aims to build on these recommendations to establish standards for a common European data base to define subgroups with prognostic significance. PMID:22371180

Ross, Fiona M; Avet-Loiseau, Hervé; Ameye, Geneviève; Gutiérrez, Norma C; Liebisch, Peter; O'Connor, Sheila; Dalva, Klara; Fabris, Sonia; Testi, Adele M; Jarosova, Marie; Hodkinson, Clare; Collin, Anna; Kerndrup, Gitte; Kuglik, Petr; Ladon, Dariusz; Bernasconi, Paolo; Maes, Brigitte; Zemanova, Zuzana; Michalova, Kyra; Michau, Lucienne; Neben, Kai; Hermansen, N Emil U; Rack, Katrina; Rocci, Alberto; Protheroe, Rebecca; Chiecchio, Laura; Poirel, Hélène A; Sonneveld, Pieter; Nyegaard, Mette; Johnsen, Hans E

2012-02-27

209

Report from the European Myeloma Network on interphase FISH in multiple myeloma and related disorders  

PubMed Central

The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report was discussed at the EHA Myeloma Scientific Working Group Meeting 2010. During the quality control exercise, there was acceptable agreement on more than 1,000 tests. The conclusions from the exercise were that the primary clinical applications for FISH analysis were for newly diagnosed cases of MM or frank relapse cases. A range of technical recommendations included: 1) material should be part of the first draw of the aspirate; 2) samples should be sent at suitable times to allow for the lengthy processing procedure; 3) most importantly, PCs must be purified or specifically identified; 4) positive cut-off levels should be relatively conservative: 10% for fusion or break-apart probes, 20% for numerical abnormalities; 5) informative probes should be combined to best effect; 6) in specialist laboratories, a single experienced analyst is considered adequate; 7) at least 100 PC should be scored; 8) essential abnormalities to test for are t(4;14), t(14;16) and 17p13 deletions; 9) suitable commercial probes should be available for clinically relevant abnormalities; 10) the clinical report should be expressed clearly and must state the percentage of PC involved and the method used for identification; 11) a retrospective European based FISH data bank linked to clinical data should be generated; and 12) prospective analysis should be centralized for upcoming trials based on the recommendations made. The European Myeloma Network aims to build on these recommendations to establish standards for a common European data base to define subgroups with prognostic significance.

Ross, Fiona M.; Avet-Loiseau, Herve; Ameye, Genevieve; Gutierrez, Norma C.; Liebisch, Peter; O'Connor, Sheila; Dalva, Klara; Fabris, Sonia; Testi, Adele M.; Jarosova, Marie; Hodkinson, Clare; Collin, Anna; Kerndrup, Gitte; Kuglik, Petr; Ladon, Dariusz; Bernasconi, Paolo; Maes, Brigitte; Zemanova, Zuzana; Michalova, Kyra; Michau, Lucienne; Neben, Kai; Hermansen, N. Emil U.; Rack, Katrina; Rocci, Alberto; Protheroe, Rebecca; Chiecchio, Laura; Poirel, Helene A; Sonneveld, Pieter; Nyegaard, Mette; Johnsen, Hans E.

2012-01-01

210

Hypogelsolinemia, a disorder of the extracellular actin scavenger system, in patients with multiple sclerosis  

PubMed Central

Background Extracellular gelsolin (GSN) and GC-globulin/Vitamin D-binding protein (DBP) appear to play an important role in clearing the actin from extracellular fluids and in modulating cellular responses to anionic bioactive lipids. In this study we hypothesized that cellular actin release and/or increase in bioactive lipids associated with multiple sclerosis (MS) development will translate into alteration of the actin scavenger system protein concentrations in blood and cerebrospinal fluid (CSF) of patients with MS. Methods We measured GSN and DBP concentrations in blood and CSF obtained from patients diagnosed with MS (n = 56) in comparison to a control group (n = 20) that includes patients diagnosed with conditions such as idiopathic cephalgia (n = 11), idiopathic (Bell's) facial nerve palsy (n = 7) and ischialgia due to discopathy (n = 2). GSN and DBP levels were measured by Western blot and ELISA, respectively. Results We found that the GSN concentration in the blood of the MS group (115 ± 78 ?g/ml) was significantly lower (p < 0.001) compared to the control group (244 ± 96 ?g/ml). In contrast, there was no statistically significant difference between blood DBP concentrations in patients with MS (310 ± 68 ?g/ml) and the control group (314 ± 82 ?g/ml). GSN and DBP concentrations in CSF also did not significantly differ between those two groups. Conclusions The decrease of GSN concentration in blood and CSF of MS subjects suggests that this protein may be involved in chronic inflammation associated with neurodegeneration. Additionally, the results presented here suggest the possible utility of GSN evaluation for diagnostic purposes. Reversing plasma GSN deficiency might represent a new strategy in MS treatment.

2010-01-01

211

The persistence of folly: critical examination of dissociative identity disorder. Part II. The defence and decline of multiple personality or dissociative identity disorder.  

PubMed

In this second part of our review, we continue to explore the illogical nature of the arguments offered to support the concept of dissociative identity disorder (DID). We also examine the harm done to patients by DID proponents' diagnostic and treatment methods. It is shown that these practices reify the alters and thereby iatrogenically encourage patients to behave as if they have multiple selves. We next examine the factors that make impossible a reliable diagnosis of DID--for example, the unsatisfactory, vague, and elastic definition of "alter personality." Because the diagnosis is unreliable, we believe that US and Canadian courts cannot responsibly accept testimony in favour of DID. Finally, we conclude with a guess about the condition's status over the next 10 years. PMID:15560314

Piper, August; Merskey, Harold

2004-10-01

212

Involvement of Youths with Autism Spectrum Disorders or Intellectual Disabilities in Multiple Public Service Systems  

ERIC Educational Resources Information Center

|The objectives of this study were to estimate the prevalence of autism spectrum disorders (ASD) and intellectual disability (ID) among youths active in at least one of five public service systems: mental health (MH), educational services for youth with serious emotional disturbance (SED), child welfare (CW), juvenile justice (JJ), and alcohol and…

Brookman-Frazee, Lauren; Baker-Ericzen, Mary; Stahmer, Aubyn; Mandell, David; Haine, Rachel A.; Hough, Richard L.

2009-01-01

213

The Presentation of Narcissistic Personality Disorder in an Octogenarian: Converging Evidence from Multiple Sources  

Microsoft Academic Search

Little is known about personality disorders (PDs) in later life. One reason for this dearth of knowledge is that many investigators believe that PDs soften with age. Recent anecdotal and empirical evidence, however, suggests that PDs are still very relevant in later life and may actually have unique presentations and consequences. The DSM-IV PD criteria seem to overlook these possibilities,

Steve Balsis; Nicholas R. Eaton; Luke D. Cooper; Thomas F. Oltmanns

2010-01-01

214

Imaging Evidence for Disturbances in Multiple Learning and Memory Systems in Persons with Autism Spectrum Disorders  

ERIC Educational Resources Information Center

|Aim: The aim of this article is to review neuroimaging studies of autism spectrum disorders (ASD) that examine declarative, socio-emotional, and procedural learning and memory systems. Method: We conducted a search of PubMed from 1996 to 2010 using the terms "autism,""learning,""memory," and "neuroimaging." We limited our review to studies…

Goh, Suzanne; Peterson, Bradley S.

2012-01-01

215

Involvement of Youths with Autism Spectrum Disorders or Intellectual Disabilities in Multiple Public Service Systems  

Microsoft Academic Search

The objectives of this study were to estimate the prevalence of autism spectrum disorders (ASD) and intellectual disability (ID) among youths active in at least one of five public service systems: mental health (MH), educational services for youth with serious emotional disturbance (SED), child welfare (CW), juvenile justice (JJ), and alcohol and drug services (AD). This study also reports the

Lauren Brookman-Frazee; Mary Baker-Ericzén; Aubyn Stahmer; David Mandell; Rachel A. Haine; Richard L. Hough

2009-01-01

216

Temperament and Attention Deficit Hyperactivity Disorder: The Development of a Multiple Pathway Model  

ERIC Educational Resources Information Center

This article outlines the parallels between major theories of attention deficit hyperactivity disorder (ADHD) and relevant temperament domains, summarizing recent research from our laboratories on (a) child temperament and (b) adult personality traits related to ADHD symptoms. These data are convergent in suggesting a role of effortful control and…

Nigg, Joel T.; Goldsmith, H. Hill; Sachek, Jennifer

2004-01-01

217

A Systematic Review of Combination Therapy with Stimulants and Atomoxetine for Attention-Deficit/Hyperactivity Disorder, Including Patient Characteristics, Treatment Strategies, Effectiveness, and Tolerability  

PubMed Central

Abstract Objective The purpose of this article was to systematically review the literature on stimulant and atomoxetine combination therapy, in particular: 1) Characteristics of patients with attention-deficit/hyperactivity disorder (ADHD) given combination therapy, 2) treatment strategies used, 3) efficacy and effectiveness, and 4) safety and tolerability. Methods Literature databases (MEDLINE®, EMBASE, Cochrane Central Register of Controlled Trials, Science Citation Index Expanded, and SciVerse Scopus) were systematically searched using prespecified criteria. Publications describing stimulant and atomoxetine combination therapy in patients with ADHD or healthy volunteers were selected for review. Exclusion criteria were comorbid psychosis, bipolar disorder, epilepsy, or other psychiatric/neurologic diseases that could confound ADHD symptom assessment, or other concomitant medication(s) to treat ADHD symptoms. Results Of the 16 publications included for review, 14 reported findings from 3 prospective studies (4 publications), 7 retrospective studies, and 3 narrative reviews/medication algorithms of patients with ADHD. The other two publications reported findings from two prospective studies of healthy volunteers. The main reason for prescribing combination therapy was inadequate response to previous treatment. In the studies of patients with ADHD, if reported, 1) most patients were children/adolescents and male, and had a combined ADHD subtype; 2) methylphenidate was most often used in combination with atomoxetine for treatment augmentation or switch; 3) ADHD symptom control was improved in some, but not all, patients; and 4) there were no serious adverse events. Conclusions Published evidence of the off-label use of stimulant and atomoxetine combination therapy is limited because of the small number of publications, heterogeneous study designs (there was only one prospective, randomized controlled trial), small sample sizes, and geographic bias. Existing evidence suggests, but does not confirm, that this drug combination may benefit some, but not all, patients who have tried several ADHD medications without success.

Gau, Susan Shur-Fen; Mendez, Luis; Montgomery, William; Monk, Julie A.; Altin, Murat; Wu, Shenghu; Lin, Chaucer C.H.; Duenas, Hector J.

2013-01-01

218

The close relationship between life-threatening breathing disorders and urine storage dysfunction in multiple system atrophy.  

PubMed

Survival of multiple system atrophy (MSA) depends on whether a variety of sleep-related breathing problems as well as autonomic failure (AF) occur. Since the brainstem lesions that cause respiratory and autonomic dysfunction overlap with each other, these critical manifestations might get worse in parallel. If so, the detection of AF, which is comparatively easy, might be predictive of a latent life-threatening breathing disorder. In 15 patients with MSA, we performed autonomic function tests composed of postural challenges and administered a questionnaire on bladder condition, as well as polysomnography and laryngoscopy during wakefulness and under anesthesia. Polysomnographic variables such as the apnea-hypopnea index (AHI) and oxygen saturation (SpO(2)) and the findings of laryngoscopy were compared with the degree of cardiac and urinary autonomic dysfunction. AHI, mean SpO(2) and the lowest SpO(2) showed significant correlations with urine storage dysfunction. In addition, patients with vocal cord abductor paralysis (VCAP) or central sleep apnea (CSA) contributing to nocturnal sudden death had more severe storage disorders than those without. On the other hand, no significant relationship between polysomnographic variables and orthostatic hypotension was observed except in the case of mean SpO(2). These results indicate that life-threatening breathing disorders have a close relationship with AF, and especially urine storage dysfunction. Therefore, longitudinal assessment of deterioration of the storage function might be useful for predicting the latent progress of VCAP and CSA. PMID:20204393

Deguchi, Kazushi; Ikeda, Kazuyo; Goto, Rieko; Tsukaguchi, Masago; Urai, Yoshiteru; Kurokohchi, Kazutaka; Touge, Tetsuo; Mori, Nozomu; Masaki, Tsutomu

2010-03-05

219

Restraint and Cancellation: Multiple Inhibition Deficits in Attention Deficit Hyperactivity Disorder  

Microsoft Academic Search

We used variations of the stop signal task to study two components of motor response inhibition—the ability to withhold a\\u000a strong response tendency (restraint) and the ability to cancel an ongoing action (cancellation)—in children with a diagnosis\\u000a of attention deficit hyperactivity disorder (ADHD) and in non-ADHD controls of similar age (ages 7–14 years). The goal was\\u000a to determine if restraint

Russell Schachar; Gordon D. Logan; Philippe Robaey; Shirley Chen; Abel Ickowicz; Cathy Barr

2007-01-01

220

Early recognition of postural disorders in multiple sclerosis through movement analysis: a modeling study  

Microsoft Academic Search

In the present study, spontaneous postural behavior has been analyzed in freely standing multiple sclerosis (MS) patients, exhibiting no clinically assessable abnormalities of postural control. This population has been compared with two other groups, healthy people and hemiparetic patients. This latter group represents a situation where the central nervous system (CNS) lesion is precisely localized in one anatomical site and

Maria Letizia Corradini; Sandro Fioretti; Tommaso Leo; Roberto Piperno

1997-01-01

221

Karyotypic abnormalities and clinical aspects of patients with multiple myeloma and related paraproteinemic disorders  

Microsoft Academic Search

Karyotypic abnormalities were detected in the malignant cells of 6 of 18 patients with multiple myeloma (MM). Six patients with benign monoclonal gammopathy, one with amyloidosis of immunoglobulin origin, and two with Waldenstroem's macroglobulinemia had normal karyotypes. All six MM patients with aneuploidy were in a group of 10 patients in an accelerated or relapse phase of their disease and

W. Liang; John E. Hopper; Janet D. Rowley

1979-01-01

222

GENERAL PRINCIPLES FOR SHORT-TERM INPATIENT WORK WITH MULTIPLE PERSONALITY-DISORDER PATIENTS  

Microsoft Academic Search

This article offers a conceptualization of the treatment course for patients with multiple personalities and describes a series of stages for the psychotherapy. A short-term inpatient unit can serve different functions during the course of treatment, ranging from diagnostic assessment, to education of both patient and therapist, to a secure holding environment in times of crisis.

David K. Sakheim; Elizabeth P. Hess; Aldine Chivas

1988-01-01

223

MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3.  

PubMed

MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased levels of p27(KIP) and temporary growth arrest of CHO cells in the G1 phase. Simultaneously, the down-regulation of DNA repair-specific proteins via miR-7 including Rad54L, and pro-apoptotic regulators such as p53, combined with the up-regulation of anti-apoptotic factors like p-Akt, promoted cell survival while arrested in G1. Thus miR-7 can co-ordinate the levels of multiple genes and proteins to influence G1 to S phase transition and the apoptotic response in order to maintain cellular homeostasis. This work provides further mechanistic insight into the role of miR-7 as a regulator of cell growth in times of cellular stress. PMID:23762407

Sanchez, Noelia; Gallagher, Mark; Lao, Nga; Gallagher, Clair; Clarke, Colin; Doolan, Padraig; Aherne, Sinead; Blanco, Alfonso; Meleady, Paula; Clynes, Martin; Barron, Niall

2013-06-06

224

Giant and multiple jejunal diverticula presenting as peritonitis a significant challenging disorder  

PubMed Central

Jejunal diverticula are an uncommon acquired disease that is usually silent and asymptomatic. When symptomatic, they present with chronic nonspecific symptoms like pain, nausea, malnutrition and sometimes with acute presentation like gastrointestinal hemorrhage, peritonitis and obstruction. The majority of complications seen as an acute abdomen similar to appendicitis, cholecystitis or colonic diverticulitis but they also may appear with atypical symptoms. We are presenting a 63-year-old male reported in emergency with painful abdomen and diagnosed as having peritonitis. On laparotomy, we incidentally found giant and multiple jejunal diverticula along with ileal perforation. Nothing was done to the jejunal diverticula, as these were multiple and non-obstructive. In the follow-up of 16 months, the patient was doing well. Jejuno-ileal diverticulosis is a rare condition that continues to present formidable challenges in diagnosis and treatment.

Singal, R; Gupta, S; Airon, A

2012-01-01

225

Multiple Self-Healing Squamous Epithelioma in Different Ethnic Groups: More than a Founder Mutation Disorder?  

Microsoft Academic Search

Multiple self-healing squamous epithelioma (MSSE), also known as Ferguson–Smith Disease, is a rare cancer-associated genodermatosis with an autosomal dominant inheritance. Affected patients suffer from recurrent skin lesions, which clinically and histologically resemble keratoacanthomas or well-differentiated squamous cell carcinomas, but which, if left, undergo spontaneous regression, leaving pronounced scarring. The majority of MSSE cases previously described were of Scottish ancestry and

Mariella D'Alessandro; Stephanie E Coats; Susan M Morley; Lorna Mackintosh; Gianpaolo Tessari; Alberto Turco; Anne-Marie Gerdes; Gabriella Pichert; Sean Whittaker; Flemming Brandrup; Sigurd Broesby-Olsen; Macarena Gomez-Lira; Giampiero Girolomoni; John C Maize; Ron J Feldman; Naoko Kato; Yukiko Koga; Malcolm A Ferguson-Smith; David R Goudie

2007-01-01

226

Evaluation and Management of Lower Urinary Tract Disorders in Women with Multiple Sclerosis  

Microsoft Academic Search

:   This paper outlines the evaluation and management of the lower urinary tract abnormalities related to voiding function in\\u000a women with multiple sclerosis (MS). For the pelvic floor reconstructive surgeon, it is important to realize that every patient\\u000a with MS may have voiding dysfunction unrelated to lower urinary tract symptoms, duration of disease or disability status.\\u000a Proper evaluation and individualized

R. R. Rackley; R. A. Appell

1999-01-01

227

Cytogenetic analyses of eight species in the genus Leptodactylus Fitzinger, 1843 (Amphibia, Anura, Leptodactylidae), including a new diploid number and a karyotype with multiple translocations  

PubMed Central

Background The karyotypes of Leptodactylus species usually consist of 22 bi-armed chromosomes, but morphological variations in some chromosomes and even differences in the 2n have been reported. To better understand the mechanisms responsible for these differences, eight species were analysed using classical and molecular cytogenetic techniques, including replication banding with BrdU incorporation. Results Distinct chromosome numbers were found: 2n = 22 in Leptodactylus chaquensis, L. labyrinthicus, L. pentadactylus, L. petersii, L. podicipinus, and L. rhodomystax; 2n = 20 in Leptodactylus sp. (aff. podicipinus); and 2n = 24 in L. marmoratus. Among the species with 2n = 22, only three had the same basic karyotype. Leptodactylus pentadactylus presented multiple translocations, L. petersii displayed chromosome morphological discrepancy, and L. podicipinus had four pairs of telocentric chromosomes. Replication banding was crucial for characterising this variability and for explaining the reduced 2n in Leptodactylus sp. (aff. podicipinus). Leptodactylus marmoratus had few chromosomes with a similar banding patterns to the 2n = 22 karyotypes. The majority of the species presented a single NOR-bearing pair, which was confirmed using Ag-impregnation and FISH with an rDNA probe. In general, the NOR-bearing chromosomes corresponded to chromosome 8, but NORs were found on chromosome 3 or 4 in some species. Leptodactylus marmoratus had NORs on chromosome pairs 6 and 8. The data from C-banding, fluorochrome staining, and FISH using the telomeric probe helped in characterising the repetitive sequences. Even though hybridisation did occur on the chromosome ends, telomere-like repetitive sequences outside of the telomere region were identified. Metaphase I cells from L. pentadactylus confirmed its complex karyotype constitution because 12 chromosomes appeared as ring-shaped chain in addition to five bivalents. Conclusions Species of Leptodactylus exhibited both major and minor karyotypic differences which were identified by classical and molecular cytogenetic techniques. Replication banding, which is a unique procedure that has been used to obtain longitudinal multiple band patterns in amphibian chromosomes, allowed us to outline the general mechanisms responsible for these karyotype differences. The findings also suggested that L. marmoratus, which was formerly included in the genus Adenomera, may have undergone great chromosomal repatterning.

2012-01-01

228

Involvement of Youths with Autism Spectrum Disorders or Intellectual Disabilities in Multiple Public Service Systems.  

PubMed

The objectives of this study were to estimate the prevalence of autism spectrum disorders (ASD) and intellectual disability (ID) among youths active in at least one of five public service systems - mental health [MH], educational services for youth with serious emotional disturbance [SED], child welfare [CW], juvenile justice [JJ], and alcohol and drug services [AD].This study also reports the characteristics and patterns of system involvement among these youths. Results indicate that approximately 12% of a random sample of youths involved in these public service systems had ID or ASD. These disabilities were particularly prevalent in youth in the SED (25%), MH (13%), and CW (13%) systems and were less prevalent in the JJ and AD systems (4% each). Youths with ID or ASD were more likely than other youths to be Caucasian, have a higher socioeconomic status, and be more likely to have externalizing psychiatric and other problems. Of those with ASD or ID, approximately one third were served in more than one service system, with the MH and SED systems most likely to be serving youths with externalizing psychiatric disorders. These findings have important implications for service provision, treatment planning, and workforce development. PMID:19809531

Brookman-Frazee, Lauren; Baker-Ericzén, Mary; Stahmer, Aubyn; Mandell, David; Haine, Rachel A; Hough, Richard L

2009-07-01

229

Transgenic Expression of MicroRNA-185 Causes a Developmental Arrest of T Cells by Targeting Multiple Genes Including Mzb1.  

PubMed

miR-185 is a microRNA (miR) that targets Bruton's tyrosine kinase in B cells, with reductions in miR-185 linked to B cell autoantibody production. In hippocampal neurons, miR-185 targets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi inhibitor. This miR is haploinsufficient in 90-95% of individuals with chromosome 22q11.2 deletion syndrome, patients who can present with immune, cardiac, and parathyroid problems, learning disorders, and a high incidence of schizophrenia in adults. The reduced levels of miR-185 in neurons cause presynaptic neurotransmitter release. Many of the 22q11.2 deletion syndrome patients have a thymic hypoplasia, which results in a peripheral T cell lymphopenia and unusual T helper cell skewing. The molecular targets of miR-185 in thymocytes are unknown. Using an miR-185 T cell transgenic approach, increasing levels of miR-185 attenuated T cell development at the T cell receptor ? (TCR?) selection checkpoint and during positive selection. This caused a peripheral T cell lymphopenia. Mzb1, Nfatc3, and Camk4 were identified as novel miR-185 targets. Elevations in miR-185 enhanced TCR-dependent intracellular calcium levels, whereas a knockdown of miR-185 diminished these calcium responses. These effects concur with reductions in Mzb1, an endoplasmic reticulum calcium regulator. Consistent with their haploinsufficiency of miR-185, Mzb1 levels were elevated in thymocyte extracts from several 22q11.2 deletion syndrome patients. Our findings indicate that miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID:24014023

Belkaya, Serkan; Murray, Sean E; Eitson, Jennifer L; de la Morena, M Teresa; Forman, James A; van Oers, Nicolai S C

2013-09-06

230

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders  

PubMed Central

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome Project, we identified a novel 421 kb de novo SHANK2 deletion in a patient with autism. We then sequenced SHANK2 in 455 patients with ASD and 431 controls and integrated these results with those reported by Berkel et al. 2010 (n?=?396 patients and n?=?659 controls). We observed a significant enrichment of variants affecting conserved amino acids in 29 of 851 (3.4%) patients and in 16 of 1,090 (1.5%) controls (P?=?0.004, OR?=?2.37, 95% CI?=?1.23–4.70). In neuronal cell cultures, the variants identified in patients were associated with a reduced synaptic density at dendrites compared to the variants only detected in controls (P?=?0.0013). Interestingly, the three patients with de novo SHANK2 deletions also carried inherited CNVs at 15q11–q13 previously associated with neuropsychiatric disorders. In two cases, the nicotinic receptor CHRNA7 was duplicated and in one case the synaptic translation repressor CYFIP1 was deleted. These results strengthen the role of synaptic gene dysfunction in ASD but also highlight the presence of putative modifier genes, which is in keeping with the “multiple hit model” for ASD. A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD.

Leblond, Claire S.; Heinrich, Jutta; Delorme, Richard; Proepper, Christian; Betancur, Catalina; Huguet, Guillaume; Konyukh, Marina; Chaste, Pauline; Ey, Elodie; Rastam, Maria; Anckarsater, Henrik; Nygren, Gudrun; Gillberg, I. Carina; Melke, Jonas; Toro, Roberto; Regnault, Beatrice; Fauchereau, Fabien; Mercati, Oriane; Lemiere, Nathalie; Skuse, David; Poot, Martin; Holt, Richard; Monaco, Anthony P.; Jarvela, Irma; Kantojarvi, Katri; Vanhala, Raija; Curran, Sarah; Collier, David A.; Bolton, Patrick; Chiocchetti, Andreas; Klauck, Sabine M.; Poustka, Fritz; Freitag, Christine M.; Waltes, Regina; Kopp, Marnie; Duketis, Eftichia; Bacchelli, Elena; Minopoli, Fiorella; Ruta, Liliana; Battaglia, Agatino; Mazzone, Luigi; Maestrini, Elena; Sequeira, Ana F.; Oliveira, Barbara; Vicente, Astrid; Oliveira, Guiomar; Pinto, Dalila; Scherer, Stephen W.; Zelenika, Diana; Delepine, Marc; Lathrop, Mark; Bonneau, Dominique; Guinchat, Vincent; Devillard, Francoise; Assouline, Brigitte; Mouren, Marie-Christine; Leboyer, Marion; Gillberg, Christopher; Boeckers, Tobias M.; Bourgeron, Thomas

2012-01-01

231

Bofu-Tsu-Shosan, an Oriental Herbal Medicine, Exerts a Combinatorial Favorable Metabolic Modulation Including Antihypertensive Effect on a Mouse Model of Human Metabolic Disorders with Visceral Obesity  

PubMed Central

Accumulating evidence indicates that metabolic dysfunction with visceral obesity is a major medical problem associated with the development of hypertension, type 2 diabetes (T2DM) and dyslipidemia, and ultimately severe cardiovascular and renal disease. Therefore, an effective anti-obesity treatment with a concomitant improvement in metabolic profile is important for the treatment of metabolic dysfunction with visceral obesity. Bofu-tsu-shosan (BOF) is one of oriental herbal medicine and is clinically available to treat obesity in Japan. Although BOF is a candidate as a novel therapeutic strategy to improve metabolic dysfunction with obesity, the mechanism of its beneficial effect is not fully elucidated. Here, we investigated mechanism of therapeutic effects of BOF on KKAy mice, a model of human metabolic disorders with obesity. Chronic treatment of KKAy mice with BOF persistently decreased food intake, body weight gain, low-density lipoprotein cholesterol and systolic blood pressure. In addition, both tissue weight and cell size of white adipose tissue (WAT) were decreased, with concomitant increases in the expression of adiponectin and peroxisome proliferator-activated receptors genes in WAT as well as the circulating adiponectin level by BOF treatment. Furthermore, gene expression of uncoupling protein-1, a thermogenesis factor, in brown adipose tissue and rectal temperature were both elevated by BOF. Intriguingly, plasma acylated-ghrelin, an active form of orexigenic hormone, and short-term food intake were significantly decreased by single bolus administration of BOF. These results indicate that BOF exerts a combinatorial favorable metabolic modulation including antihypertensive effect, at least partially, via its beneficial effect on adipose tissue function and its appetite-inhibitory property through suppression on the ghrelin system.

Azushima, Kengo; Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Ohsawa, Masato; Uneda, Kazushi; Kobayashi, Ryu; Kanaoka, Tomohiko; Dejima, Toru; Fujikawa, Tetsuya; Yamashita, Akio; Toya, Yoshiyuki; Umemura, Satoshi

2013-01-01

232

Gender role across development in adults with 46,XY disorders of sex development including perineoscrotal hypospadias and small phallus raised male or female.  

PubMed

Self-rated degree of femininity and masculinity across development were evaluated for 40 adults affected by 46,XY disorders of sex development (DSDs) who presented at birth with a small phallus and perineoscrotal hypospadias, raised either male (n = 22) or female (n = 18). Most participants were confirmed or presumed to be affected by partial androgen insensitivity syndrome (n = 14), partial gonadal dysgenesis (n = 11), or were considered to have a poorly defined case of 46,XY DSD including ambiguous external genitalia (n = 15). Participants retrospectively evaluated their degree of masculinity and femininity during their childhood, adolescence, adulthood, and in the past 12 months of filling out a questionnaire pertaining to their psychosexual development. Participants raised male reported more masculinity than those raised female due to an increase in masculinization during adolescence and adulthood. Participants raised male also reported less femininity than those raised female throughout development. Participants raised female reported more femininity than those raised male due to an increase in feminization during adolescence and adulthood. Participants raised female also reported less masculinity than those raised male throughout development. These data support the proposition that some aspects of gender role (GR), such as masculinity and femininity, are capable of proceeding along female- or male-typic patterns depending on sex of rearing among individuals affected by specific types of 46,XY DSD. Furthermore, regardless of male or female rearing, GR increasingly corresponds with assigned sex as individuals proceed through sexual maturity and into adulthood. These results are consistent with the idea that socialization/learning contributes to GR development in humans in addition to data from others demonstrating endocrine influences. PMID:18780596

Pappas, Kara B; Wisniewski, Amy B; Migeon, Claude J

2008-07-01

233

Bofu-tsu-shosan, an oriental herbal medicine, exerts a combinatorial favorable metabolic modulation including antihypertensive effect on a mouse model of human metabolic disorders with visceral obesity.  

PubMed

Accumulating evidence indicates that metabolic dysfunction with visceral obesity is a major medical problem associated with the development of hypertension, type 2 diabetes (T2DM) and dyslipidemia, and ultimately severe cardiovascular and renal disease. Therefore, an effective anti-obesity treatment with a concomitant improvement in metabolic profile is important for the treatment of metabolic dysfunction with visceral obesity. Bofu-tsu-shosan (BOF) is one of oriental herbal medicine and is clinically available to treat obesity in Japan. Although BOF is a candidate as a novel therapeutic strategy to improve metabolic dysfunction with obesity, the mechanism of its beneficial effect is not fully elucidated. Here, we investigated mechanism of therapeutic effects of BOF on KKAy mice, a model of human metabolic disorders with obesity. Chronic treatment of KKAy mice with BOF persistently decreased food intake, body weight gain, low-density lipoprotein cholesterol and systolic blood pressure. In addition, both tissue weight and cell size of white adipose tissue (WAT) were decreased, with concomitant increases in the expression of adiponectin and peroxisome proliferator-activated receptors genes in WAT as well as the circulating adiponectin level by BOF treatment. Furthermore, gene expression of uncoupling protein-1, a thermogenesis factor, in brown adipose tissue and rectal temperature were both elevated by BOF. Intriguingly, plasma acylated-ghrelin, an active form of orexigenic hormone, and short-term food intake were significantly decreased by single bolus administration of BOF. These results indicate that BOF exerts a combinatorial favorable metabolic modulation including antihypertensive effect, at least partially, via its beneficial effect on adipose tissue function and its appetite-inhibitory property through suppression on the ghrelin system. PMID:24130717

Azushima, Kengo; Tamura, Kouichi; Wakui, Hiromichi; Maeda, Akinobu; Ohsawa, Masato; Uneda, Kazushi; Kobayashi, Ryu; Kanaoka, Tomohiko; Dejima, Toru; Fujikawa, Tetsuya; Yamashita, Akio; Toya, Yoshiyuki; Umemura, Satoshi

2013-10-09

234

[Conduction disorders at multiple levels during the acute phase of a myocardial infarct: an electrophysiological study].  

PubMed

Forty patients with a diagnosis of acute myocardial infarction (anterior 24, and inferior 16) were studied. Of these patients, 37.5% manifested second and third degree atrioventricular (AV) block as a complication; another 30% showed complete right bundle branch and left anterior hemiblock. Right bundle branch and left posterior hemiblock were evidenced in 12.5% of the subjects. There was 20% with complete left bundle branch block. Electrophysiologic studies were performed in all patients to assess the site of block. A direct relation was found between the surface ECG and the His bundle electrogram studies in patients with an inferior myocardial infarction and AV block, both procedures located the conduction disturbances at the AV node (suprahisian block), in contrast to patients with anteroseptal myocardial infarction whose surface ECG only showed bundle branch block or fascicular block. The His bundle electrogram registered multiple levels of AV block, 70% with troncular and infrahisian block that gave way to sudden AV block. The mechanism responsible for this block was considered to be a functional longitudinal dissociation of conduction system due to an acute ischemic injury of the His bundle, more than a sudden and simultaneous failure of all the bundle branch of His. We conclude that electrophysiologic studies are a useful procedure for identification of a group of patients with multiple AV conduction disturbances that have a less favorable prognosis than those with only suprahisian level of block. PMID:8503713

García Burgos, A; Rangel Abundis, A; Castaño, R; Ramos, M A; Badui, E

235

Multiple sclerosis  

MedlinePLUS

Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord ( central nervous system ). ... Multiple sclerosis (MS) affects women more than men. The disorder is most commonly diagnosed between ages 20 and ...

236

Conservative two-step procedure including uterine artery embolization with embosphere and surgical myomectomy for the treatment of multiple fibroids: Preliminary experience  

Microsoft Academic Search

ObjectiveTo evaluate the feasibility and safety of combined uterine artery embolization (UAE) using embosphere and surgical myomectomy as an alternative to radical hysterectomy in premenopausal women with multiple fibroids.

Cécile Malartic; Olivier Morel; Yann Fargeaudou; Olivier Le Dref; Afchine Fazel; Emmanuel Barranger; Philippe Soyer

237

Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor ?, in response to deacetylase inhibition by valproic acid and trichostatin A  

Microsoft Academic Search

Valproate (VPA) and trichostatin A (TSA), inhibitors of zinc-dependent deacetylase activity, induce reduction in the levels of mRNA encoding oestrogen receptor-? (ER?), resulting in subsequent clearance of ER? protein from breast and ovarian cell lines. Inhibition of oestrogen signalling may account for the endocrine disorders, menstrual abnormalities, osteoporosis and weight gain that occur in a proportion of women treated with

George Reid; Raphaël Métivier; Chin-Yo Lin; Stefanie Denger; David Ibberson; Tomi Ivacevic; Heike Brand; Vladimir Benes; Edison T Liu; Frank Gannon

2005-01-01

238

[The estimation of the efficacy of manual therapy included in the combined treatment of cochlear-vestibular disorders based on the results of computed stabilography].  

PubMed

The objective of the present study was to estimate the efficacy of the combined treatment of spondylogenic cochlear-vestibular disorders with the use of both medicamental and non-medicamental modalities. Computed static stabilometry was applied for diagnostics of postural disbalance and evaluation of the treatment outcomes. It was shown that the application of manual therapy for the management of 56 patients presenting with spondylogenic cochlear-vestibular disorders resulted in the decrease of tinnitus and the improvement of vestibular and cochlear functions. PMID:22810637

Shempeleva, A É; Lopatin, A S; Morozova, S V; Gridin, L A

2012-01-01

239

Prospective Follow-Up of Girls with Attention-Deficit/Hyperactivity Disorder into Early Adulthood: Continuing Impairment Includes Elevated Risk for Suicide Attempts and Self-Injury  

ERIC Educational Resources Information Center

|Objective: We performed a 10-year prospective follow-up of a childhood-ascertained (6-12 years), ethnically and socioeconomically diverse sample of girls with attention-deficit/hyperactivity disorder (ADHD; N = 140: combined type [ADHD-C] n = 93; inattentive type [ADHD-I] n = 47) plus a matched comparison group (N = 88). Girls were recruited from…

Hinshaw, Stephen P.; Owens, Elizabeth B.; Zalecki, Christine; Huggins, Suzanne Perrigue; Montenegro-Nevado, Adriana J.; Schrodek, Emily; Swanson, Erika N.

2012-01-01

240

The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis\\/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders  

Microsoft Academic Search

BACKGROUND: We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH\\/overlap syndromes and in cases with coexistence of AIH and other liver diseases. METHODS: We applied the IAHG score in 423 patients with liver diseases excluding patients with AIH,

Panagiotis A Papamichalis; Kalliopi Zachou; George K Koukoulis; Aikaterini Veloni; Efthimia G Karacosta; Lampros Kypri; Ioannis Mamaloudis; Stella Gabeta; Eirini I Rigopoulou; Ansgar W Lohse; George N Dalekos

2007-01-01

241

Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders.  

PubMed Central

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome predisposing to tumors of the parathyroid, endocrine pancreas, anterior pituitary, adrenal glands, and diffuse neuroendocrine tissues. The MEN1 gene has been assigned, by linkage analysis and loss of heterozygosity, to chromosome 11q13 and recently has been identified by positional cloning. In this study, a total of 84 families and/or isolated patients with either MEN1 or MEN1-related inherited endocrine tumors were screened for MEN1 germ-line mutations, by heteroduplex and sequence analysis of the MEN1 gene-coding region and untranslated exon 1. Germ-line MEN1 alterations were identified in 47/54 (87%) MEN1 families, in 9/11 (82%) isolated MEN1 patients, and in only 6/19 (31.5%) atypical MEN1-related inherited cases. We characterized 52 distinct mutations in a total of 62 MEN1 germ-line alterations. Thirty-five of the 52 mutations were frameshifts and nonsense mutations predicted to encode for a truncated MEN1 protein. We identified eight missense mutations and five in-frame deletions over the entire coding sequence. Six mutations were observed more than once in familial MEN1. Haplotype analysis in families with identical mutations indicate that these occurrences reflected mainly independent mutational events. No MEN1 germ-line mutations were found in 7/54 (13%) MEN1 families, in 2/11 (18%) isolated MEN1 cases, in 13/19 (68. 5%) MEN1-related cases, and in a kindred with familial isolated hyperparathyroidism. Two hundred twenty gene carriers (167 affected and 53 unaffected) were identified. No evidence of genotype-phenotype correlation was found. Age-related penetrance was estimated to be >95% at age >30 years. Our results add to the diversity of MEN1 germ-line mutations and provide new tools in genetic screening of MEN1 and clinically related cases.

Giraud, S; Zhang, C X; Serova-Sinilnikova, O; Wautot, V; Salandre, J; Buisson, N; Waterlot, C; Bauters, C; Porchet, N; Aubert, J P; Emy, P; Cadiot, G; Delemer, B; Chabre, O; Niccoli, P; Leprat, F; Duron, F; Emperauger, B; Cougard, P; Goudet, P; Sarfati, E; Riou, J P; Guichard, S; Rodier, M; Meyrier, A; Caron, P; Vantyghem, M C; Assayag, M; Peix, J L; Pugeat, M; Rohmer, V; Vallotton, M; Lenoir, G; Gaudray, P; Proye, C; Conte-Devolx, B; Chanson, P; Shugart, Y Y; Goldgar, D; Murat, A; Calender, A

1998-01-01

242

"Helpful People in Touch" Consumer Led Self Help Programs for People with Multiple Disorders, Mental Illness, Drug Addiction, and Alcoholism (MIDAA).  

ERIC Educational Resources Information Center

|This paper describes the consumer program, "Helpful People in Touch," a self-help treatment program for people with the multiple disorders of mental illness, drug addiction, and/or alcoholism. First, the terms, "Mentally Ill Chemical Abusers and Addicted" (MICAA) and "Chemical Abusing Mentally Ill" (CAMI) are defined and differentiated, with…

Sciacca, Kathleen

243

Parental Perspectives on the Importance and Likelihood of Adult Outcomes for Children with Autism Spectrum Disorders, Intellectual Disabilities or Multiple Disabilities  

ERIC Educational Resources Information Center

Aims: This study examined parental perspectives on the importance and likelihood of future adult outcomes for children with Autism Spectrum Disorders (ASD), Intellectual Disabilities (ID), or Multiple Disabilities (MD) and some of the factors that may affect parental aspirations. Methods: Parents of 105 children with ASD, ID, or MD were presented…

Poon, Kenneth K.; Koh, Lynette; Magiati, Iliana

2013-01-01

244

The Diagnostic Drawing Series and the Tree Rating Scale: An Isomorphic Representation of Multiple Personality Disorder, Major Depression, and Schizophrenic Populations.  

ERIC Educational Resources Information Center

The tree drawings of 80 subjects, who were diagnosed with either multiple personality disorder, schizophrenia, or major depression, and a control group, were rated. Patterns were examined and graphs were used to depict results. Certain features were found to distinguish each category. The descriptive statistical findings were both consistent and…

Morris, Maureen Batza

1995-01-01

245

The Work of Antoine Despine: The First Scientific Report on the Diagnosis and Treatment of a Child with Multiple Personality Disorder  

Microsoft Academic Search

Papers describing the signs and symptoms of multiple personality disorder (MPD) are increasing in the contemporary scientific literature where, ironically, the clinical researchers of today are rediscovering phenomena already documented in nineteenth century medical texts. Indeed, 150 years ago, there were already psychiatric monographs discussing the diagnosis and treatment of MPD. One of these monographs was written by Antoine Despine,

Catherine G. Fine

1988-01-01

246

The 1994-95 North Carolina State Testing Results. Multiple-Choice End-of-Grade and End-of-Course Tests Including English II Essay.  

ERIC Educational Resources Information Center

|This document provides information on average student performance at the state level on end-of-grade (grades 3 through 8 in reading and mathematics and grades 4 through 8 in social studies) multiple-choice tests and all end-of-course (high school courses) tests administered in 1994-95 as part of the North Carolina Testing Program. State-level…

North Carolina State Dept. of Public Instruction, Div. of Accountability.

247

Prevalence and significant determinants of post-traumatic stress disorder in a large sample of patients with multiple sclerosis.  

PubMed

Chronic and life-threatening neurodegenerative diseases may be associated with post-traumatic stress disorder (PTSD). Therefore, the current study was an investigation of the prevalence of PTSD in multiple sclerosis (MS) patients, and identification of significant determinants of PTSD. Two hundred thirty-two MS patients were consecutively recruited and screened for the presence of PTSD with the Impact of Event Scale-Revised, corroborated by the Structured Clinical Interview for DSM-IV. Furthermore, participants were administered the Hospital Anxiety and Depression Scale and the Fatigue Severity Scale. Twelve patients (12/232, i.e. 5.17 %) were diagnosed as suffering from PTSD. Levels of education, anxiety and depression were significant determinants of the presence of PTSD. The role played by the levels of education, anxiety and depression in determining the presence of PTSD has been discussed. Further research on the psychological features of neurodegenerative diseases is urgently needed in order to plan appropriate treatments and improve patients' quality of life. PMID:23053829

Ostacoli, Luca; Carletto, Sara; Borghi, Martina; Cavallo, Marco; Rocci, Emanuela; Zuffranieri, Marco; Malucchi, Simona; Bertolotto, Antonio; Zennaro, Alessandro; Furlan, Pier Maria; Picci, Rocco Luigi

2013-06-01

248

Safety and efficacy assessment of plerixafor in patients with multiple myeloma proven or predicted to be poor mobilizers, including assessment of tumor cell mobilization  

Microsoft Academic Search

This was an open-label, single-center, phase II study of 20 patients with multiple myeloma who were either proven poor mobilizers (n=10; group A) or predicted poor mobilizers (n=10; group B) and were planned for autologous hematopoietic SCT. The aim was to assess the safety and efficacy of plerixafor for stem cell mobilization and tumor cell contamination. The peripheral blood (PB)

G Tricot; M H Cottler-Fox; G Calandra

2010-01-01

249

Differences in the nature of body image disturbances between female obese individuals with versus without a co-morbid Binge Eating Disorder: an exploratory study including static and dynamic aspects of body image  

Microsoft Academic Search

Various components of body image were measured to assess body image disturbances in patients with obesity. To overcome limitations of previous studies, a photo distortion technique and a biological motion distortion device were included to assess static and dynamic aspects of body image. Questionnaires assessed cognitive-affective aspects, bodily attitudes, and eating behavior. Patients with obesity and a binge eating disorder

Tanja Legenbauer; V. Vocks; Sabrina Betz; María José Báguena Puigcerver; Andrea Benecke; Nikolaus F. Troje; Heinz Rüddel

2011-01-01

250

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis  

PubMed Central

PTPN11, which encodes the tyrosine phosphatase SHP2, is mutated in approximately 35% of patients with juvenile myelomonocytic leukemia (JMML) and at a lower incidence in other neoplasms. To model JMML pathogenesis, we generated knockin mice that conditionally express the leukemia-associated mutant Ptpn11D61Y. Expression of Ptpn11D61Y in all hematopoietic cells evokes a fatal myeloproliferative disorder (MPD), featuring leukocytosis, anemia, hepatosplenomegaly, and factor-independent colony formation by bone marrow (BM) and spleen cells. The Lin?Sca1+cKit+ (LSK) compartment is expanded and “right-shifted,” accompanied by increased stem cell factor (SCF)–evoked colony formation and Erk and Akt activation. However, repopulating activity is decreased in diseased mice, and mice that do engraft with Ptpn11D61Y stem cells fail to develop MPD. Ptpn11D61Y common myeloid progenitors (CMPs) and granulocyte-monocyte progenitors (GMPs) produce cytokine-independent colonies in a cell-autonomous manner and demonstrate elevated Erk and Stat5 activation in response to granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulation. Ptpn11D61Y megakaryocyte-erythrocyte progenitors (MEPs) yield increased numbers of erythrocyte burst-forming units (BFU-Es), but MEPs and erythrocyte-committed progenitors (EPs) produce fewer erythrocyte colony-forming units (CFU-Es), indicating defective erythroid differentiation. Our studies provide a mouse model for Ptpn11-evoked MPD and show that this disease results from cell-autonomous and distinct lineage-specific effects of mutant Ptpn11 on multiple stages of hematopoiesis.

Kalaitzidis, Demetrios; Usenko, Tatiana; Kutok, Jeffery L.; Yang, Wentian; Mohi, M. Golam; Neel, Benjamin G.

2009-01-01

251

Eating Disorders  

MedlinePLUS

Eating disorders are serious behavior problems. They can include severe overeating or not consuming enough food to stay ... concern about your shape or weight. Types of eating disorders include Anorexia nervosa, in which you become too ...

252

A multiple translocation event in a patient with hexadactyly, facial dysmorphism, mental retardation and behaviour disorder characterised comprehensively by molecular cytogenetics. Case report and review of the literature  

Microsoft Academic Search

We report a 13-year-old female patient with multiple congenital abnormalities (microcephaly, facial dysmorphism, anteverted dysplastic ears and postaxial hexadactyly), mental retardation, and adipose-gigantism. Ultrasonography revealed no signs of a heart defect or renal abnormalities. She showed no speech development and suffered from a behavioural disorder. CNS abnormalities were excluded by cerebral MRI. Initial cytogenetic studies by Giemsa banding revealed an

Jörg Seidel; Anita Heller; Gabriele Senger; Heike Starke; Ilse Chudoba; Christina Kelbova; Holger Tönnies; Heidemarie Neitzel; Claudia Haase; Volkmar Beensen; Felix Zintl; Uwe Claussen; Thomas Liehr

2003-01-01

253

An evaluation of a brief multiple-stimulus preference assessment with adolescents with emotional-behavioral disorders in an educational setting.  

PubMed

Brief multiple-stimulus-without-replacement (MSWO) preference assessments were conducted with 3 adolescent boys with emotional-behavioral disorders in the context of their public school educational program. The reinforcing effects of stimuli identified as high, medium, and low preference were then evaluated using an alternating treatments design in which, following an initial baseline, stimuli were delivered contingent on on-task behavior. High-preference stimuli produced the highest percentages of on-task behavior for all 3 participants. PMID:16270849

Paramore, Nancy W; Higbee, Thomas S

2005-01-01

254

An Evaluation of a Brief Multiple-stimulus Preference assessment with Adolescents with Emotional-behavioral disorders in an Educational Setting  

PubMed Central

Brief multiple-stimulus-without-replacement (MSWO) preference assessments were conducted with 3 adolescent boys with emotional-behavioral disorders in the context of their public school educational program. The reinforcing effects of stimuli identified as high, medium, and low preference were then evaluated using an alternating treatments design in which, following an initial baseline, stimuli were delivered contingent on on-task behavior. High-preference stimuli produced the highest percentages of on-task behavior for all 3 participants.

2005-01-01

255

Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins  

PubMed Central

In the past few years, many retrovirus receptors, coreceptors, and cofactors have been identified. These molecules are important for some aspects of viral entry, although in some cases it remains to be determined whether they are required for binding or postbinding stages in entry, such as fusion. There are certain common features to the molecules that many retroviruses use to gain entry into the cell. For example, the receptors for most mammalian oncoretroviruses are multiple membrane-spanning transport proteins. However, avian retroviruses use single-pass membrane proteins, and a sheep retrovirus uses a glycosylphosphatidylinositol-anchored molecule as its receptor. For some retroviruses, particularly the lentiviruses, two cell surface molecules are required for efficient entry. More recently, a soluble protein that is required for viral entry has been identified for a feline oncoretrovirus. In this review, we will focus on the various strategies used by mammalian retroviruses to gain entry into the cell. The choice of receptors will also be discussed in light of pressures that drive viral evolution and persistence.

Overbaugh, Julie; Miller, A. Dusty; Eiden, Maribeth V.

2001-01-01

256

[A case of recurrent non-small cell lung cancer successfully treated with multiple modality therapies including S-1 monotherapy as fifth-line chemotherapy hospital)].  

PubMed

An 80-year-old man with no complaint was referred to our department because of high serum CEA level. He was diagnosed as non-small cell lung cancer(adenocarcinoma)of the left lower lobe(c-T2aN0M0, stage I B), and therefore the left lower lobectomy with lymph node dissection was performed. Pathological staging was p-T2aN1(#10)M0, stage II A, and EGFR mutation was negative. Adjuvant chemotherapy with UFT was started, but multiple hilar and mediastinal lymph nodes metastases soon appeared. Carboplatin(CBDCA)+paclitaxel(PTX), erlotinib, and docetaxel(DOC)were attempted after that, but the lymph nodes increased in size and the CEA level was up to 159.8 ng/mL. At about the same time, brain and pulmonary metastases were recognized. After radiation for the chest lymph nodes and stereotactic radiosurgery(SRS)for the brain metastasis, oral S-1 monotherapy was introduced. Soon after, the lymph nodes shrinked and the CEA level decreased. Also, the pulmonary metastasis disappeared. Although a right supraclavicular lymph node metastasis was resected during the clinical course, the S-1 monotherapy has been continued with no serious adverse event. He is well(PS 0)without recurrent lesion, and his serum CEA level is within the normal limit. PMID:24047779

Yokosuka, Tetsuya; Kobayashi, Toshiko; Enomoto, Tatsuji; Takeda, Atsuya

2013-09-01

257

Deep RNA sequencing of L. monocytogenes reveals overlapping and extensive stationary phase and sigma B-dependent transcriptomes, including multiple highly transcribed noncoding RNAs  

Microsoft Academic Search

BACKGROUND: Identification of specific genes and gene expression patterns important for bacterial survival, transmission and pathogenesis is critically needed to enable development of more effective pathogen control strategies. The stationary phase stress response transcriptome, including many ?B-dependent genes, was defined for the human bacterial pathogen Listeria monocytogenes using RNA sequencing (RNA-Seq) with the Illumina Genome Analyzer. Specifically, bacterial transcriptomes were

Haley F Oliver; Renato H Orsi; Lalit Ponnala; Uri Keich; Wei Wang; Qi Sun; Samuel W Cartinhour; Melanie J Filiatrault; Martin Wiedmann; Kathryn J Boor

2009-01-01

258

Tetrasomy 15q25.2?qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation.  

PubMed

We report on a male neonate with prenatally diagnosed mosaicism for a supernumerary marker chromosome and multiple congenital anomalies. Prenatal ultrasound imaging revealed a heart defect, pleural effusion, clubbed feet, and absent right kidney. Clinical cytogenetic analysis of amniocytes identified a marker chromosome present in 10 out of 15 cells analyzed. Clinical evaluation of the neonate revealed distinct facial features, complex heart defects, solitary left kidney, and arachnodactyly. Chromosome analysis of lymphocytes demonstrated an abnormal male karyotype with a marker chromosome present in all 24 cells examined. To identify the marker chromosome, SNP microarray analysis was performed which detected the presence of a two copy gain of 17.7?Mb of DNA from the distal long arm of chromosome 15 (15q25.2-qter). FISH analysis using a probe specific to the 15q26.3 region showed one signal on each normal 15q and two signals, one on each arm of the marker chromosome resulting in four copies. Distal tetrasomy 15q is rare. Only 11 cases have been described in the literature, all due to a supernumerary analphoid marker chromosome consisting of an inverted duplication of the distal long arm of chromosome 15. We report on a unique patient with tetrasomy 15q with complex cardiovascular malformation (CVM) involving progressive diffuse pulmonary vein stenosis (PVS). We propose overexpression of three genes, ADAMTSL3, MESP1, and MESP2 as a potential mechanism for cardiac and vessel malformations associated with tetrasomy 15q. Finally, we believe cardiac defects with this genetic syndrome are a poor prognostic finding associated with high mortality. PMID:22711292

George-Abraham, Jaya K; Zimmerman, Sarah L; Hinton, Robert B; Marino, Bradley S; Witte, David P; Hopkin, Robert J

2012-06-18

259

Subthreshold Conditions as Precursors for Full Syndrome Disorders: A 15-Year Longitudinal Study of Multiple Diagnostic Classes  

ERIC Educational Resources Information Center

|Background: There has been increasing interest in the distinction between subthreshold and full syndrome disorders and specifically whether subthreshold conditions escalate or predict the onset of full syndrome disorders over time. Most of these studies, however, examined whether a single subthreshold condition escalates into the full syndrome…

Shankman, Stewart A.; Lewinsohn, Peter M.; Klein, Daniel N.; Small, Jason W.; Seeley, John R.; Altman, Sarah E.

2009-01-01

260

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders  

Microsoft Academic Search

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome

Claire S. Leblond; Jutta Heinrich; Richard Delorme; Christian Proepper; Catalina Betancur; Guillaume Huguet; Marina Konyukh; Pauline Chaste; Elodie Ey; Maria Rastam; Henrik Anckarsäter; Gudrun Nygren; I. Carina Gillberg; Jonas Melke; Roberto Toro; Beatrice Regnault; Fabien Fauchereau; Oriane Mercati; Nathalie Lemière; David Skuse; Martin Poot; Richard Holt; Anthony P. Monaco; Irma Järvelä; Katri Kantojärvi; Raija Vanhala; Sarah Curran; David A. Collier; Patrick Bolton; Andreas Chiocchetti; Sabine M. Klauck; Fritz Poustka; Christine M. Freitag; Regina Waltes; Marnie Kopp; Eftichia Duketis; Elena Bacchelli; Fiorella Minopoli; Liliana Ruta; Agatino Battaglia; Luigi Mazzone; Elena Maestrini; Ana F. Sequeira; Barbara Oliveira; Astrid Vicente; Guiomar Oliveira; Dalila Pinto; Stephen W. Scherer; Diana Zelenika; Marc Delepine; Mark Lathrop; Dominique Bonneau; Vincent Guinchat; Françoise Devillard; Brigitte Assouline; Marie-Christine Mouren; Marion Leboyer; Christopher Gillberg; Tobias M. Boeckers; Thomas Bourgeron

2012-01-01

261

Subthreshold Conditions as Precursors for Full Syndrome Disorders: A 15-Year Longitudinal Study of Multiple Diagnostic Classes  

ERIC Educational Resources Information Center

Background: There has been increasing interest in the distinction between subthreshold and full syndrome disorders and specifically whether subthreshold conditions escalate or predict the onset of full syndrome disorders over time. Most of these studies, however, examined whether a single subthreshold condition escalates into the full syndrome…

Shankman, Stewart A.; Lewinsohn, Peter M.; Klein, Daniel N.; Small, Jason W.; Seeley, John R.; Altman, Sarah E.

2009-01-01

262

Reliability and Diagnostic Efficiency of the Diagnostic Inventory for Disharmony (DID) in Youths with Pervasive Developmental Disorder and Multiple Complex Developmental Disorder  

ERIC Educational Resources Information Center

|The Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) category is a psychopathological entity few have described and is poorly, and mainly negatively, defined by autism exclusion. In order to limit PDD-NOS heterogeneity, alternative clinical constructs have been developed. This study explored the reliability and the diagnostic…

Xavier, Jean; Vannetzel, Leonard; Viaux, Sylvie; Leroy, Arthur; Plaza, Monique; Tordjman, Sylvie; Mille, Christian; Bursztejn, Claude; Cohen, David; Guile, Jean-Marc

2011-01-01

263

The clinical obesity maintenance model: an integration of psychological constructs including mood, emotional regulation, disordered overeating, habitual cluster behaviours, health literacy and cognitive function.  

PubMed

Psychological distress and deficits in executive functioning are likely to be important barriers to effective weight loss maintenance. The purpose of this paper is twofold. First, in the light of recent evidence in the fields of neuropsychology and obesity, particularly on the deficits in the executive function in overweight and obese individuals, a conceptual and theoretical framework of obesity maintenance is introduced by way of a clinical obesity maintenance model (COMM). It is argued that psychological variables, that of habitual cluster Behaviors, emotional dysregulation, mood, and health literacy, interact with executive functioning and impact on the overeating/binge eating behaviors of obese individuals. Second, cognizant of this model, it is argued that the focus of obesity management should be extended to include a broader range of maintaining mechanisms, including but not limited to cognitive deficits. Finally, a discussion on potential future directions in research and practice using the COMM is provided. PMID:23710346

Raman, Jayanthi; Smith, Evelyn; Hay, Phillipa

2013-02-14

264

Caenorhabditis elegans Cyclin B3 Is Required for Multiple Mitotic Processes Including Alleviation of a Spindle Checkpoint-Dependent Block in Anaphase Chromosome Segregation  

PubMed Central

The master regulators of the cell cycle are cyclin-dependent kinases (Cdks), which influence the function of a myriad of proteins via phosphorylation. Mitotic Cdk1 is activated by A-type, as well as B1- and B2-type, cyclins. However, the role of a third, conserved cyclin B family member, cyclin B3, is less well defined. Here, we show that Caenorhabditis elegans CYB-3 has essential and distinct functions from cyclin B1 and B2 in the early embryo. CYB-3 is required for the timely execution of a number of cell cycle events including completion of the MII meiotic division of the oocyte nucleus, pronuclear migration, centrosome maturation, mitotic chromosome condensation and congression, and, most strikingly, progression through the metaphase-to-anaphase transition. Our experiments reveal that the extended metaphase delay in CYB-3–depleted embryos is dependent on an intact spindle assembly checkpoint (SAC) and results in salient defects in the architecture of holocentric metaphase chromosomes. Furthermore, genetically increasing or decreasing dynein activity results in the respective suppression or enhancement of CYB-3–dependent defects in cell cycle progression. Altogether, these data reveal that CYB-3 plays a unique, essential role in the cell cycle including promoting mitotic dynein functionality and alleviation of a SAC–dependent block in anaphase chromosome segregation.

Deyter, Gary M. R.; Furuta, Tokiko; Kurasawa, Yasuhiro; Schumacher, Jill M.

2010-01-01

265

Prenatal diagnosis of partial trisomy 3q resulting from t(3;14) in a fetus with multiple anomalies including vermian hypoplasia.  

PubMed

While genetic origin of Dandy-Walker complex has not yet fully elucidated, the complex has been known to be associated with structural and chromosomal abnormalities. A partial trisomy 3q was also identified in patients with DWC. 3q duplication syndrome is defined as duplications of large parts of 3q, especially 3q21-qter. Most cases with 3q duplication are diagnosed postnatally and the patients show typical features including various facial dysmorphisms, congenital heart defects, genitourinary malformations, and mental and growth retardation. Here we report a 28 year old nulliparous woman who was referred from the infertility clinic at 21 gestational weeks. Fetal ultrasonographic examination showed various abnormal findings including a ventricular septal defect, hydrocephalus, and hypoplasia of the cerebellar vermis. Fetal chromosome analysis was initially reported as 46,XY,der(14)(?::p11.2?qter). Array CGH followed by FISH allowed precise characterization of the der(14) chromosome and the initial karyotype of the fetus had been changed to 46,XY,add(14)(p11).ish der(14)t(3;14)(q26.1;p11)(tel3q+).arr 3q26.1q29(166249469-199288361)x3. Though further studies are required, gene clusters rather than a single gene might be responsible for the clinical features of the Dandy-Walker complex. PMID:22366303

Jung, Sang Hee; Shim, Sung Han; Park, Sang Hee; Park, Ji Eun; Park, Hea Ree; Ahn, Eun Hee; Kim, Soo Hyun; Cha, Dong Hyun

2012-02-16

266

Multiple Domains in MtENOD8 Protein Including the Signal Peptide Target It to The Symbiosome1[W][OA  

PubMed Central

Symbiotic nitrogen fixation occurs in nodules, specialized organs on the roots of legumes. Within nodules, host plant cells are infected with rhizobia that are encapsulated by a plant-derived membrane forming a novel organelle, the symbiosome. In Medicago truncatula, the symbiosome consists of the symbiosome membrane, a single rhizobium, and the soluble space between them, called the symbiosome space. The symbiosome space is enriched with plant-derived proteins, including the M. truncatula EARLY NODULIN8 (MtENOD8) protein. Here, we present evidence from green fluorescent protein (GFP) fusion experiments that the MtENOD8 protein contains at least three symbiosome targeting domains, including its N-terminal signal peptide (SP). When ectopically expressed in nonnodulated root tissue, the MtENOD8 SP delivers GFP to the vacuole. During the course of nodulation, there is a nodule-specific redirection of MtENOD8-SP-GFP from the vacuole to punctate intermediates and subsequently to symbiosomes, with redirection of MtENOD8-SP-GFP from the vacuole to punctate intermediates preceding intracellular rhizobial infection. Experiments with M. truncatula mutants having defects in rhizobial infection and symbiosome development demonstrated that the MtNIP/LATD gene is required for redirection of the MtENOD8-SP-GFP from the vacuoles to punctate intermediates in nodules. Our evidence shows that MtENOD8 has evolved redundant targeting sequences for symbiosome targeting and that intracellular localization of ectopically expressed MtENOD8-SP-GFP is useful as a marker for monitoring the extent of development in mutant nodules.

Meckfessel, Matthew H.; Blancaflor, Elison B.; Plunkett, Michael; Dong, Qunfeng; Dickstein, Rebecca

2012-01-01

267

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma  

PubMed Central

Background TMEFF2 is a protein containing a single EGF-like domain and two follistatin-like modules. The biological function of TMEFF2 remains unclear with conflicting reports suggesting both a positive and a negative association between TMEFF2 expression and human cancers. Methodology/Principal Findings Here we report that the extracellular domain of TMEFF2 interacts with PDGF-AA. This interaction requires the amino terminal region of the extracellular domain containing the follistatin modules and cannot be mediated by the EGF-like domain alone. Furthermore, the extracellular domain of TMEFF2 interferes with PDGF-AA–stimulated fibroblast proliferation in a dose–dependent manner. TMEFF2 expression is downregulated in human brain cancers and is negatively correlated with PDGF-AA expression. Suppressed expression of TMEFF2 is associated with its hypermethylation in several human tumor types, including glioblastoma and cancers of ovarian, rectal, colon and lung origins. Analysis of glioma subtypes indicates that TMEFF2 hypermethylation and decreased expression are associated with a subset of non-Proneural gliomas that do not display CpG island methylator phentoype. Conclusions/Significance These data provide the first evidence that TMEFF2 can function to regulate PDGF signaling and that it is hypermethylated and downregulated in glioma and several other cancers, thereby suggesting an important role for this protein in the etiology of human cancers.

Lin, Kui; Taylor, James R.; Wu, Thomas D.; Gutierrez, Johnny; Elliott, J. Michael; Vernes, Jean-Michel; Koeppen, Hartmut; Phillips, Heidi S.; de Sauvage, Frederic J.; Meng, Y. Gloria

2011-01-01

268

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.  

PubMed Central

The DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (AGT), is inactivated by reaction with the pseudosubstrate, O(6)-benzylguanine (BG). This inactivation sensitizes tumour cells to chemotherapeutic alkylating agents, and BG is aimed at enhancing cancer treatment in clinical trials. Point mutations in a 24 amino acid sequence likely to form the BG-binding pocket were identified using a screening method designed to identify BG-resistant mutants. It was found that alterations in 21 of these residues were able to render AGT resistant to BG. These included mutations at the highly conserved residues Lys(165), Leu(168) and Leu(169). The two positions at which changes led to the largest increase in resistance to BG were Gly(156) and Lys(165). Eleven mutants at Gly(156) were identified, with increases in resistance ranging from 190-fold (G156V) to 4400-fold (G156P). Two mutants at Lys(165) found in the screen (K165S and K165A) showed 620-fold and 100-fold increases in resistance to BG. Two mutants at the Ser(159) position (S159I and S159V) were >80-fold more resistant than wild-type AGT. Eleven active mutants at Leu(169) were also resistant to BG, but with lower increases (5-86-fold). Fourteen BG-resistant mutants were found for position Cys(150), with 3-26-fold increases in the amount of inhibitor needed to produce a 50% loss of activity in a 30 min incubation. Six BG-resistant mutants at Asn(157) were found with increases of 4-13-fold. These results show that many changes can render human AGT resistant to BG without preventing the ability to protect tumour cells from therapeutic alkylating agents.

Xu-Welliver, M; Pegg, A E

2000-01-01

269

Treatment of lower urinary tract dysfunction in patients with multiple sclerosis. Committee of the European Study Group of SUDIMS (Sexual and Urological Disorders in Multiple Sclerosis)  

Microsoft Academic Search

Bladder symptoms in patients with multiple sclerosis (MS) are common and usually arise as a result of spinal lesions which interrupt the neural pathways connecting the pontine micturition centre to the sacral spinal cord. Thus these symptoms are particularly likely to occur in those with lower limb neurological deficits. Fortunately bladder dysfunction in MS is rarely associated with serious upper

C J Fowler; P E van Kerrebroeck; A Nordenbo; H Van Poppel

1992-01-01

270

Presentation and Validation of the Multiple Sclerosis Depression Rating Scale: A Test Specifically Devised to Investigate Affective Disorders in Multiple Sclerosis Patients  

Microsoft Academic Search

Accurate diagnosis of depression in patients affected by MS is important, as it may be a cause of reduced quality of life and increased suicide risk. We present a new scale, the Multiple Sclerosis Depression Rating Scale (MSDRS), and assess its diagnostic accuracy in comparison to the Beck Depression Inventory (BDI). A total of 94 MS participants were classified as

Davide Quaranta; Camillo Marra; Massimiliano Zinno; Agata Katia Patanella; Maria Josè Messina; Chiara Piccininni; Anna Paola Batocchi; Guido Gainotti

2012-01-01

271

First-principles study of multiple order-disorder transitions in Cd2AgAu Heusler alloys  

Microsoft Academic Search

The bcc-based Heusler alloys exhibit a series of order-disorder phase transitions as a function of temperature. The high-temperature phase is a disordered bcc solid solution, and the low-temperature phase is the Heusler structure. An intermediate ordered phase is also typically observed in real systems. A prototype cluster variation method (CVM) analysis is presented that shows that the relative stabilities of

R. McCormack; D. de Fontaine

1996-01-01

272

Multiple Sources of Attentional Dysfunction in Adults With Tourette's Syndrome: Comparison With Attention Deficit–Hyperactivity Disorder  

Microsoft Academic Search

Seventeen adult Tourette's syndrome (TS) patients, 17 adult attention deficit–hyperactivity disorder (ADHD) patients, and 17 adult controls completed a battery of attentional tests and self-report measures of ADHD and obsessive–compulsive disorder (OCD) symptoms. ADHD but not TS participants performed significantly worse than controls on tests of mental flexibility and psychomotor speed. Both the ADHD and TS groups, however, had significantly

Steven M. Silverstein; Peter G. Como; Donna R. Palumbo; Laura L. West; Leah M. Osborn

1995-01-01

273

Communication problems with environment-related health disorders as illustrated by a multiple chemical sensitivity (MCS) chatroom.  

PubMed

The problem of communication in treating multiple chemical sensitivity (MCS) was analysed and evaluated using the documentation of an MCS chatroom which was set up in April 2001 following the TV programme Gesundheitsmagazin Praxis (Health Magazine: Practice). Approaches were developed for solving communication problems in the chatroom. A total of 490 cases were evaluated, most of which (355) were directly or indirectly affected, 76 came from self-help groups and 10 were from 4 guest experts invited by ZDF (Zweites Deutsches Fernsehen, Second German TV channel). Of these 4 experts, 2 were environmental medicine specialists, 1 psychosomatics expert and 1 psychiatrist. Fourty-nine of the cases included a petition for chatroom participants to join a class-action law. Aside from exchanging basic information on MCS, frequent topics of discussion on the air were the assessment of physicians, clinics, self-help groups and experts. The participants also expressed their views on problems with society, politics, the economy, science and social security. Another common topic was communication in the chatroom itself, which for the most part consisted of sarcasm and insults, which were cause for conflicts in the chatroom. These communication problems led to the conclusion that a chatroom is not the best medium for discussing MCS. If a chatroom is to be used profitably to this end, it is imperative to have a well-defined organisational framework which allows the exchange of current, scientifically accurate information while keeping discussions from escalating and degenerating into arguments. PMID:15729837

Jaks, Heike; Hornberg, Claudia; Dott, Wolfgang; Wiesmüller, Gerhard Andreas

2004-12-01

274

Diagnosing and treating comorbid (complicated) bipolar disorder.  

PubMed

Comorbidity is the rule, not the exception, in bipolar disorder. The most common mental disorders that co-occur with bipolar disorder in community studies include anxiety, substance use, and conduct disorders. Disorders of eating, sexual behavior, attention-deficit/hyperactivity, and impulse control, as well as autism spectrum disorders and Tourette's disorder, co-occur with bipolar disorder in clinical samples. The most common general medical comorbidities are migraine, thyroid illness, obesity, type II diabetes, and cardiovascular disease. Bipolarity is a marker for comorbidity, and comorbid disorders, especially multiple conditions occurring when a patient is young, may be a marker for bipolarity. Relatively few controlled clinical studies have examined the treatment of bipolar disorder in the context of comorbid conditions (i.e., complicated or comorbid bipolar disorder). However, the first step in treating any type of complicated bipolar disorder--stabilizing a patient's mood--may be associated with improving the comorbid disorder. Standard mood stabilizers, atypical antipsychotics, and non-antimanic antiepileptic agents are emerging as potentially useful treatments for several of the disorders that frequently co-occur with bipolar disorder, and therefore may be useful treatments for comorbid bipolar disorder. PMID:15554795

McElroy, Susan L

2004-01-01

275

Dissociative Disorders  

MedlinePLUS

... trauma and help keep difficult memories at bay. Treatment for dissociative disorders may include psychotherapy, hypnosis and medication. ... epilepsy. Treatments and drugs Psychotherapy is the primary treatment for dissociative disorders. This form of therapy, also known ...

276

Movements in autistic disorder  

Microsoft Academic Search

Autistic disorder, an extremely disabling syndrome with onset in early childhood, is associated with multiple comorbid conditions. Although autistic disorder is hetergeneous in its manifestations, there is a subgroup of individuals with autistic disorder who display movements that appear to be unique for the disorders. Hand flapping and a variety of movements termed stereotypies may be pathognomonic of autistic disorder.

J. R. Brasi?

1999-01-01

277

Compulsive disorders  

Microsoft Academic Search

Compulsive disorders include a diverse group of conditions characterized by excessive thoughts or preoccupations combined\\u000a with poorly controlled behaviors. They include trichotillomania, kleptomania, pathologic gambling, compulsive buying disorder,\\u000a compulsive sexual behavior, and compulsive computer use. Some investigators have suggested that these conditions constitute\\u000a a spectrum of disorders linked to obsessive-compulsive disorder. Others have questioned the validity of this conceptualization,\\u000a and

John M. Kuzma; Donald W. Black

2004-01-01

278

Schizoid Personality Disorder  

MedlinePLUS

... of disorders, which includes schizotypal personality disorder and schizophrenia. These conditions all have similar symptoms, such as ... emotional expression. However, unlike schizotypal personality disorder and schizophrenia, people with schizoid personality disorder: Are in touch ...

279

Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder  

PubMed Central

Background We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consistently demonstrated the reduction of RORA transcript and/or protein levels in blood-derived lymphoblasts as well as in the postmortem prefrontal cortex and cerebellum of individuals with ASD. Moreover, we have also shown that RORA has the potential to be under negative and positive regulation by androgen and estrogen, respectively, suggesting the possibility that RORA may contribute to the male bias of ASD. However, little is known about transcriptional targets of this nuclear receptor, particularly in humans. Methods Here we identify transcriptional targets of RORA in human neuronal cells on a genome-wide level using chromatin immunoprecipitation (ChIP) with an anti-RORA antibody followed by whole-genome promoter array (chip) analysis. Selected potential targets of RORA were then validated by an independent ChIP followed by quantitative PCR analysis. To further demonstrate that reduced RORA expression results in reduced transcription of RORA targets, we determined the expression levels of the selected transcriptional targets in RORA-deficient human neuronal cells, as well as in postmortem brain tissues from individuals with ASD who exhibit reduced RORA expression. Results The ChIP-on-chip analysis reveals that RORA1, a major isoform of RORA protein in human brain, can be recruited to as many as 2,764 genomic locations corresponding to promoter regions of 2,544 genes across the human genome. Gene ontology analysis of this dataset of genes that are potentially directly regulated by RORA1 reveals statistically significant enrichment in biological functions negatively impacted in individuals with ASD, including neuronal differentiation, adhesion and survival, synaptogenesis, synaptic transmission and plasticity, and axonogenesis, as well as higher level functions such as development of the cortex and cerebellum, cognition, memory, and spatial learning. Independent ChIP-quantitative PCR analyses confirm binding of RORA1 to promoter regions of selected ASD-associated genes, including A2BP1, CYP19A1, ITPR1, NLGN1, and NTRK2, whose expression levels (in addition to HSD17B10) are also decreased in RORA1-repressed human neuronal cells and in prefrontal cortex tissues from individuals with ASD. Conclusions Findings from this study indicate that RORA transcriptionally regulates A2BP1, CYP19A1, HSD17B10, ITPR1, NLGN1, and NTRK2, and strongly suggest that reduction of this sex hormone-sensitive nuclear receptor in the brain causes dysregulated expression of these ASD-relevant genes as well as their associated pathways and functions which, in turn, may contribute to the underlying pathobiology of ASD.

2013-01-01

280

Current treatment of selected pediatric sleep disorders.  

PubMed

While pediatric sleep disorders are relatively common, treatments are often not straightforward. There is often a paucity of gold standard studies and data available to guide clinicians, treatments may yield arguably incomplete results, interventions may require chronic use, and/ or involve multiple modalities including behavioral interventions that require high parental and family commitment. This review points out diagnostic differences compared to adults and focuses on current therapy for selected common pediatric sleep disorders including sleep disordered breathing/ obstructive sleep apnea, narcolepsy, and restless legs syndrome. Other common pediatric sleep disorders, such as insomnia and parasomnias, are not covered. PMID:23055049

Sullivan, Shannon S

2012-10-01

281

Treatment of lower urinary tract dysfunction in patients with multiple sclerosis. Committee of the European Study Group of SUDIMS (Sexual and Urological Disorders in Multiple Sclerosis)  

PubMed Central

Bladder symptoms in patients with multiple sclerosis (MS) are common and usually arise as a result of spinal lesions which interrupt the neural pathways connecting the pontine micturition centre to the sacral spinal cord. Thus these symptoms are particularly likely to occur in those with lower limb neurological deficits. Fortunately bladder dysfunction in MS is rarely associated with serious upper tract disease so that the problem is usually one of symptomatic management. Lower urinary tract symptoms may be both "irritative" or "obstructive" in nature and can be explained in terms of underlying detrusor hyperreflexia and incomplete bladder emptying. Treatment is aimed at minimising both these effects. Oral anticholinergic medication can be effective in reducing detrusor hyperreflexia and intermittent catheterisation is used to reduce abnormally high post micturition residual volumes. With this simple treatment, often used in combination, many less severely affected patients with MS can gain considerable improvement in controlling urinary continence.

Fowler, C J; van Kerrebroeck, P E; Nordenbo, A; Van Poppel, H

1992-01-01

282

Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board.  

PubMed

Kidney dysfunction is a common clinical feature of symptomatic multiple myeloma. Some degree of renal insufficiency or renal failure is present at diagnosis or will occur during the course of the disease and, if not reversed, will adversely affect overall survival and quality of life. Chronic insults to the kidneys from other illnesses, treatment, or multiple myeloma itself can further damage renal function and increase the risk for additional complications, such as anemia. Patients with multiple myeloma who have light chain (Bence Jones protein) proteinuria may experience renal failure or progress to end-stage renal disease (ESRD) and require dialysis because of light chain cast nephropathy. Kidney failure in patients with presumed multiple myeloma also may result from amyloidosis, light chain deposition disease, or acute tubular necrosis caused by nephrotoxic agents; therefore, identification of patients at risk for kidney damage is essential. The International Myeloma Foundation's Nurse Leadership Board has developed practice recommendations for screening renal function, identifying positive and negative contributing risk and environmental factors, selecting appropriate therapies and supportive care measures to decrease progression to ESRD, and enacting dialysis to reduce and manage renal complications in patients with multiple myeloma. PMID:21816711

Faiman, Beth M; Mangan, Patricia; Spong, Jacy; Tariman, Joseph D; The International Myeloma Foundation Nurse Leadership Board

2011-08-01

283

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1982-01-01

284

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1979-01-01

285

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1980-01-01

286

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1985-01-01

287

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1981-01-01

288

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1986-01-01

289

Clinical Evaluation and Treatment of Multiple Myeloma and Other Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1984-01-01

290

Treatment of Reactivated Post-Traumatic Stress DisorderImaginal Exposure in an Older Adult With Multiple Traumas  

Microsoft Academic Search

A single-case analysis was used to assess the effects of imaginal exposure in a 57-year-old woman suffering from current and reactivated post-traumatic stress disorder (PTSD) following a transient ischemic attack. The client’s responses to self-reported depression, anxiety, and PTSD symptoms were repeatedly recorded during four phases: (a) initial psychotherapy, (b) imaginal exposure, (c) skill generalization, and (d) fading of treatment.

Stephen A. Russo; Michel Hersen; Vincent B. van Hasselt

2001-01-01

291

Developmental Expression Mapping of a Gene Implicated in Multiple Neurodevelopmental Disorders, A2bp1 (Fox1)  

Microsoft Academic Search

The neuronal transcription splicing factor, A2BP1, has been implicated in a variety of neurodevelopmental disorders; however, the role of A2BP1 in brain development and gene regulatory function remains to be explicated. Here, we map A2bp1 gene expression, focusing on the developing forebrain of the C57BL6J mouse. Early in forebrain development, A2bp1 expression is highly reminiscent of the expression of genes

Elizabeth A. D. Hammock; Pat Levitt

2011-01-01

292

Collaborative Care for patients with severe borderline and NOS personality disorders: A comparative multiple case study on processes and outcomes  

Microsoft Academic Search

Background  Structured psychotherapy is recommended as the preferred treatment of personality disorders. A substantial group of patients,\\u000a however, has no access to these therapies or does not benefit. For those patients who have no (longer) access to psychotherapy\\u000a a Collaborative Care Program (CCP) is developed. Collaborative Care originated in somatic health care to increase shared decision\\u000a making and to enhance self

Barbara Stringer; Berno van Meijel; Bauke Koekkoek; A. J. F. M. Kerkhof; Aartjan Beekman

2011-01-01

293

Alcohol criteria endorsement and psychiatric and drug use disorders among DUI offenders: Greater severity among women and multiple offenders  

PubMed Central

Purpose Data from the Collaborative Study on the Genetics of Alcoholism (COGA), a high-risk family study of alcohol dependence, were used to examine differences in alcohol diagnostic criteria endorsement and psychiatric and drug use disorders by gender and by number of DUI offenses. Results Individuals with two or more DUIs exhibited greater severity of alcohol dependence than those with none or one DUI. This severity was characterized in three ways: (1) higher endorsement of alcohol diagnostic criterion items, with evidence of greater severity among women, (2) higher prevalence of co-occurring lifetime psychiatric disorders, and (3) higher rates of drug use and of dependence on cocaine, stimulants, and, for women only, marijuana and opiates. Conclusions By examining gradations of disorder within a combination of two high-risk indicators, DUI and family vulnerability, this study provides useful information for clinical research about individuals with chronic and severe alcohol problems. In addition, the observed gender differences in this high-risk sample will contribute to the literature on alcohol dependence among women at the more severe end of the dependence spectrum.

McCutcheon, Vivia V.; Heath, Andrew C.; Edenberg, Howard J.; Grucza, Richard A.; Hesselbrock, Victor M.; Kramer, John R.; Bierut, Laura Jean; Bucholz, Kathleen K.

2010-01-01

294

Mania in neurologic disorders.  

PubMed

Neurologic disorders can produce "secondary" mania. Clinicians must distinguish secondary mania from primary, idiopathic manic-depressive illness (MBI). In addition to medical and drug-induced causes of secondary mania, neurologic causes usually develop in older patients who may lack a strong family history of MDI. Neurologic causes of mania include focal strokes in the right basotemporal or inferofrontal region, strokes or tumors in the perihypothalamic region, Huntington's disease and other movement disorders, multiple sclerosis and other white matter diseases, head trauma, infections such as neurosyphilis and Creutzfeldt-Jakob disease, and frontotemporal dementia. Patients with new-onset mania require an evaluation that includes a thorough history, a neurologic examination, neuroimaging, and other selected tests. The management of patients with neurologic mania involving correcting the underlying disorder when possible and the judicious use of drugs such as the anticonvulsant medications. PMID:11122994

Mendez, M F

2000-10-01

295

"Nothing like Pretend": Difference, Disorder, and Dystopia in the Multiple World Spaces of Philip Pullman's "His Dark Materials"  

ERIC Educational Resources Information Center

|This article examines the multiple worlds in Philip Pullman's "His Dark Materials" trilogy in light Pierre Bourdieu's "space of possibles" and the combination of chance and choice that impact Lyra and Will's decisions. Rather than viewing chance or destiny as disempowering, this article considers how the protagonists' choices also encourage…

Cantrell, Sarah K.

2010-01-01

296

The potential use of adult stem cells for the treatment of multiple sclerosis and other neurodegenerative disorders  

Microsoft Academic Search

No specific treatment exists for patients with multiple sclerosis (MS) who fail to respond to conventional immunosuppressive and immunomodulating modalities. Furthermore, no method is available for regeneration of existing defect in the central nervous system (CNS). The ultimate goals of MS treatment, similarly to other autoimmune diseases, are twofold: first, to eliminate self-reactive lymphocytes and to prevent de novo development

Shimon Slavin; Basan G. S. Kurkalli; Dimitrios Karussis

2008-01-01

297

Multiple endocrine diseases in cats: 15 cases (1997-2008).  

PubMed

The objective of this retrospective study was to characterize a population of cats from a tertiary care center diagnosed with multiple endocrine disorders, including the specific disorders and time intervals between diagnosis of each disorder. Medical records of 15 cats diagnosed with more than one endocrine disorder were reviewed. The majority of cats were domestic shorthairs, and the mean age at the time of diagnosis of the first disorder was 10.3 years. The most common combination of disorders was diabetes mellitus and hyperthyroidism. Two cats had concurrent diabetes mellitus and hyperadrenocorticism, one cat had concurrent central diabetes insipidus and diabetes mellitus. A mean of 25.7 months elapsed between diagnoses of the first and second endocrine disorder, but this was variable. This study suggests the occurrence of multiple endocrine disorders is uncommon in cats. PMID:20580584

Blois, Shauna L; Dickie, Erica L; Kruth, Stephen A; Allen, Dana G

2010-06-26

298

Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.  

PubMed

The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control region 1 (ICR1) located at chromosome 11p15.5. This methylation-sensitive chromatin insulator works by binding the zinc-finger protein CTCF in a parent-specific manner. DNA methylation defects involving the ICR1 H19/IGF2 domain result in two growth disorders with opposite phenotypes: an overgrowth disorder, the Beckwith-Wiedemann syndrome (maternal ICR1 gain of methylation in 10% of BWS cases) and a growth retardation disorder, the Silver-Russell syndrome (paternal ICR1 loss of methylation in 60% of SRS cases). Although a few deletions removing part of ICR1 have been described in some familial BWS cases, little information is available regarding the mechanism of ICR1 DNA methylation defects. We investigated the CTCF gene and the ICR1 domain in 21 BWS patients with ICR1 gain of methylation and 16 SRS patients with ICR1 loss of methylation. We identified four constitutional ICR1 genetic defects in BWS patients, including a familial case. Three of those defects are newly identified imprinting defects consisting of small deletions and a single mutation, which do not involve one of the CTCF binding sites. Moreover, two of those defects affect OCT-binding sequences which are suggested to maintain the unmethylated state of the maternal allele. A single-nucleotide variation was identified in a SRS patient. Our data extends the spectrum of constitutive genetic ICR1 abnormalities and suggests that extensive and accurate analysis of ICR1 is required for appropriate genetic counseling in BWS patients with ICR1 gain of methylation. PMID:20007505

Demars, Julie; Shmela, Mansur Ennuri; Rossignol, Sylvie; Okabe, Jun; Netchine, Irène; Azzi, Salah; Cabrol, Sylvie; Le Caignec, Cédric; David, Albert; Le Bouc, Yves; El-Osta, Assam; Gicquel, Christine

2009-12-09

299

[Developmental disorders].  

PubMed

Developmental disorders, which are usually diagnosed in infancy, childhood, or adolescence, include mental retardation, learning disorders, motor skills disorder, communication disorders, pervasive developmental disorders (PDD), attention-deficit hyperactivity disorder (ADHD), and tic disorders. Epidemiological studies have indicated that these disorders are characterized not only by high heritability (e.g., 0.80 for PDD) but also by their shared genetic etiology. Furthermore, retrospective or prospective longitudinal studies have revealed that adult psychiatric disorders are often preceded either by their juvenile counterparts (homotypic continuity) or by different disorders (heterotypic continuity). Recent genetic studies have detected copy number variants (CNVs; e.g., deletions on 1q21.1, 3q29, and 22q.11.21 and duplications on 16p11.2) as shared genetic factors for PDD, mental retardation, and schizophrenia. While these CNVs are generally very rare (<1%), their effect size is much larger than that of single nucleotide polymorphisms. Although the mechanism by which CNVs cause these abnormalities remains unclear, pleiotropic effect of CNVs may provide insights into the high rate of comorbidity among developmental disorders and heterotypic continuity between developmental disorders and adult disorders. In addition, longitudinal neuroimaging studies have provided evidence for irregularities in the typical trajectories in developmental disorders. For instance, retarded cortical development is identified in ADHD in cortical trajectory, and early acceleration of brain growth is identified in PDD. Finally, we outlined several research topics as the future direction for investigation of developmental disorders: a longitudinal clinical study in subjects with specific disorder-related CNVs; detailed analysis of genetic factors relevant to developmental disorders, including smaller CNVs and INDELs; and functional analysis of genetic factors by using induced pluripotent stem cell technology or non-human primate animal models. PMID:22308259

Kushima, Itaru; Okada, Takashi; Ozaki, Norio

2012-02-01

300

Multiple tumor types including leiomyoma and Wilms tumor in a patient with Gorlin syndrome due to 9q22.3 microdeletion encompassing the PTCH1 and FANC-C loci.  

PubMed

Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant condition mainly characterized by the development of mandibular keratocysts which often have their onset during the second decade of life and/or multiple basal cell carcinoma (BCC) normally arising during the third decade. Cardiac and ovarian fibromas can be found. Patients with NBCCS develop the childhood brain malignancy medulloblastoma (now often called primitive neuro-ectodermal tumor [PNET]) in 5% of cases. The risk of other malignant neoplasms is not clearly increased, although lymphoma and meningioma can occur in this condition. Wilms tumor has been mentioned in the literature four times. We describe a patient with a 10.9?Mb 9q22.3 deletion spanning 9q22.2 through 9q31.1 that includes the entire codifying sequence of the gene PTCH1, with Wilms tumor, multiple neoplasms (lung, liver, mesenteric, gastric and renal leiomyomas, lung typical carcinoid tumor, adenomatoid tumor of the pleura) and a severe clinical presentation. We propose including leiomyomas among minor criteria of the NBCCS. © 2013 Wiley Periodicals, Inc. PMID:24124115

Garavelli, Livia; Piemontese, Maria Rosaria; Cavazza, Alberto; Rosato, Simonetta; Wischmeijer, Anita; Gelmini, Chiara; Albertini, Enrico; Albertini, Giuseppe; Forzano, Francesca; Franchi, Fabrizia; Carella, Massimo; Zelante, Leopoldo; Superti-Furga, Andrea

2013-10-07

301

Traumatic brain injury and sleep disorders.  

PubMed

Sleep disturbance is common after traumatic brain injury (TBI). Insomnia, fatigue, and sleepiness are the most frequent post-TBI sleep complaints with narcolepsy (with or without cataplexy), sleep apnea (obstructive or central), periodic limb movement disorder, and parasomnias occurring less commonly. In addition, depression, anxiety, and pain are common TBI comorbidities with substantial influence on sleep quality. Diagnosis of sleep disorders after TBI may involve polysomnography, multiple sleep latency testing, or actigraphy. Treatment is disorder-specific and includes the use of medications, continuous positive airway pressure, or behavioral modifications. Unfortunately, treatment of sleep disorders associated with TBI often does not improve sleepiness or neuropsychologic function. PMID:23099139

Viola-Saltzman, Mari; Watson, Nathaniel F

2012-11-01

302

Loneliness and Eating Disorders  

Microsoft Academic Search

This article examines the link between loneliness and eating disorders. This concept is evaluated through a systematic review of the literature that links loneliness and eating disorders and through a survey of themes connecting the 2 conditions. Eating disorders—including anorexia nervosa, bulimia nervosa, and eating disorders that are not otherwise specified, which include binge eating disorder—are challenging health issues. Each

Martha Peaslee Levine

2012-01-01

303

Recurrent hypoglycemia during pregnancies in a woman with multiple autoantibodies including anti-insulin receptor antibody and anti-platelet antibody, whose serum lowered murine blood glucose levels and phosphorylated insulin receptor of CHO-IR cells.  

PubMed

We report a rare case of recurrent hypoglycemia in a pregnant woman during the period of pregnancies. She suffered from severe hypoglycemia and intrauterine fetal death during the first pregnancy. Thereafter, there was no hypoglycemia, and no obvious cause of hypoglycemia was found by close examinations. Two years later, at eight weeks into the second pregnancy, hypoglycemia recurred. The patient had multiple auto-antibodies including anti-insulin receptor antibody and anti-platelet antibody associated with decreased platelet count. She completed the pregnancy with continuous intravenous administration of glucose that prevented hypoglycemia and finally delivered a healthy baby by Caesarian section. Both the hypoglycemia and thrombocytopenia, and the auto-antibodies disappeared after the delivery. We analyzed the patient's serum as a possible cause of hypoglycemia. Administration of the serum lowered blood glucose levels of mice more strongly than control serum. In addition, the serum phosphorylated tyrosine of insulin receptor of Chinese hamster ovary cells overexpressing human insulin receptors (CHO-IR cells) in vitro. These results suggest that multiple auto-antibodies might have been induced by a trigger of pregnancy, although the precise mechanism was unclear, and the anti-insulin receptor antibody and anti-platelet antibody might have induced hypoglycemia and thrombocytopenia, respectively, during the pregnancy. PMID:21931226

Toshihiro, Makiko; Katagiri, Hideki; Kataoka, Koujiro; Fukushima, Akimune; Segawa, Toshie; Fujiwara, Takuya; Hikichi, Isao; Takebe, Noriko; Satoh, Jo

2011-09-17

304

Relationships of personality and psychiatric disorders to multiple domains of smoking motives and dependence in middle-aged adults  

PubMed Central

Introduction: Individual differences in psychopathology and personality may associate with dependence on smoking for specific motivational reasons. However, the associations among psychopathology, personality, and smoking dependence and motives have not been examined simultaneously in studies to date, leaving it unclear whether specific patterns of affective and behavioral functioning are associated with specific aspects of smoking dependence. Methods: The present study examined these associations in 296 current smokers aged 35–43 years. Smoking dependence and motives were assessed with structured interview, the Fagerström Test for Nicotine Dependence, and the Wisconsin Inventory of Smoking Dependence Motives. Results: Regardless of the measure of smoking dependence tested, a lifetime history of major depression and high levels of trait stress reaction were consistently related to greater current smoking dependence severity. Substance dependence showed significant associations with some measures of smoking dependence but had relatively few effects when entered in models along with depression history and trait stress reaction. In multivariate models, alcohol dependence and conduct disorder history did not show unique significant associations with smoking dependence nor did trait aggression, alienation, control, or harm avoidance. Discussion: Results indicate little specificity in the associations of particular psychiatric diagnoses or personality traits with specific self-reported facets of smoking dependence. It appears that a general vulnerability to depression and negative emotions is the most robust indicator of vulnerability to high levels of self-reported smoking dependence, regardless of which dimensions of smoking dependence are analyzed.

Leventhal, Adam M.; Daughters, Stacey B.; Clark, Melissa A.; Colby, Suzanne M.; Ramsey, Susan E.; Boergers, Julie; Abrams, David B.; Niaura, Raymond; Buka, Stephen L.

2010-01-01

305

Endocrine causes of calcium disorders.  

PubMed

Endocrine diseases that may cause hypercalcemia and hypocalcemia include hyperparathyroidism, hypoparathyroidism, thyroid disorders, hyperadrenocorticism, hypoadrenocorticism, and less commonly pheochromocytoma and multiple endocrine neoplasias. The differential diagnosis of hypercalcemia may include malignancy (lymphoma, anal sac carcinoma, and squamous cell carcinoma), hyperparathyroidism, vitamin D intoxication, chronic renal disease, hypoadrenocorticism, granulomatous disorders, osteolysis, or spurious causes. Hypocalcemia may be caused by puerperal tetany, pancreatitis, intestinal malabsorption, ethlyene glycol intoxication, acute renal failure, hypopararthyroidism, hypovitaminosis D, hypomagnesemia, and low albumin. This article focuses on the endocrine causes of calcium imbalance and provides diagnostic and therapeutic guidelines for identifying the cause of hypercalcemia and hypocalcemia in veterinary patients. PMID:23415381

Greco, Deborah S

2012-11-01

306

Advantages of the multiple case series approach to the study of cognitive deficits in autism spectrum disorder  

PubMed Central

In the neuropsychological case series approach, tasks are administered that tap different cognitive domains, and differences within rather than across individuals are the basis for theorising; each individual is effectively their own control. This approach is a mainstay of cognitive neuropsychology, and is particularly suited to the study of populations with heterogeneous deficits. However it has very rarely been applied to the study of cognitive differences in autism spectrum disorder (ASD). Here, we investigate whether this approach can yield information beyond that given by the typical group study method, when applied to an ASD population. Twenty-one high-functioning adult ASD participants and 22 IQ, age, and gender-matched control participants were administered a large battery of neuropsychological tests that would represent a typical neuropsychological assessment for neurological patients in the United Kingdom. The data were analysed using both group and single-case study methods. The group analysis revealed a limited number of deficits, principally on tests with a large executive function component, with no impairment in more routine abilities such as basic attending, language and perception. Single-case study analysis proved more fruitful revealing evidence of considerable variation in abilities both between and within ASD participants. Both sub-normal and supra-normal performance were observed, with the most defining feature of the ASD group being this variability. We conclude that the use of group-level analysis alone in the study of cognitive deficits in ASD risks missing cognitive characteristics that may be vitally important both theoretically and clinically, and even may be misleading because of averaging artifact.

Towgood, Karren J.; Meuwese, Julia D.I.; Gilbert, Sam J.; Turner, Martha S.; Burgess, Paul W.

2009-01-01

307

Diversity in Pathways to Common Childhood Disruptive Behavior Disorders  

ERIC Educational Resources Information Center

|Oppositional-Defiant Disorder (ODD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are highly comorbid, a phenomenon thought to be due to shared etiological factors and mechanisms. Little work has attempted to chart multiple-level-of-analysis pathways (i.e., simultaneously including biological, environmental, and trait influences) to ODD and…

Martel, Michelle M.; Nikolas, Molly; Jernigan, Katherine; Friderici, Karen; Nigg, Joel T.

2012-01-01

308

Child and Adolescent Anxiety Disorders and Early Attachment  

Microsoft Academic Search

ObjectiveThe major aim of this research is to determine whether infants who were anxiously\\/resistantly attached in infancy develop more anxiety disorders during childhood and adolescence than infants who were securely attached. To test different theories of anxiety disorders, newborn temperament and maternal anxiety were included in multiple regression analyses.

SUSAN L. WARREN; LISA HUSTON; BYRON EGELAND; L. ALAN SROUFE

1997-01-01

309

Diversity in Pathways to Common Childhood Disruptive Behavior Disorders  

ERIC Educational Resources Information Center

Oppositional-Defiant Disorder (ODD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are highly comorbid, a phenomenon thought to be due to shared etiological factors and mechanisms. Little work has attempted to chart multiple-level-of-analysis pathways (i.e., simultaneously including biological, environmental, and trait influences) to ODD and…

Martel, Michelle M.; Nikolas, Molly; Jernigan, Katherine; Friderici, Karen; Nigg, Joel T.

2012-01-01

310

Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders.  

PubMed

Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent finding in multiple sclerosis (MS) and acute inflammatory (IND) and non-inflammatory neurological diseases (OND), but not in neurodegenerative diseases (ND), systemic inflammatory disease and healthy controls. Furthermore, we demonstrate intrathecal production of anti-Nogo-A antibodies measured by increased IgG indices. Intrathecal anti-Nogo antibodies were significantly more frequent in patients with relapsing-remitting as compared to chronic progressive (CP) MS. We also found a highly significant negative correlation of these antibody responses with age indicating that they are more frequent in younger patients. We finally demonstrate that human anti-Nogo-A antibodies recognize native Nogo-A in brain extracts, oligodendrocytes and cells expressing human Nogo-A. PMID:14644040

Reindl, Markus; Khantane, Sabrina; Ehling, Rainer; Schanda, Kathrin; Lutterotti, Andreas; Brinkhoff, Claudia; Oertle, Thomas; Schwab, Martin E; Deisenhammer, Florian; Berger, Thomas; Bandtlow, Christine E

2003-12-01

311

Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders  

PubMed Central

Recent studies have demonstrated that one-third of known microRNAs (miRNAs) are stably detectable in plasma. Therefore, we assessed plasma miRNAs to investigate the dynamics of oncomir 17-92a, which is highly expressed in multiple myeloma (MM) patients. The plasma miR-92a level in symptomatic MM patients was significantly downregulated compared with normal subjects (P<0.0001), regardless of immunoglobulin subtypes or disease stage at diagnosis. In contrast, miR-92a levels in peripheral blood CD8+ or CD4+ cells from MM patients were lower than those of normal subjects, and the miR-92a levels of the cells tended to correlate with plasma miR-92a levels. The plasma miR-92a level in the complete remission group became normalized, whereas the partial response (PR) and very good PR groups did not reach the normal range. In smoldering MM, the plasma miR-92a level did not show a significant difference compared with normal subjects. Our findings suggest that measurement of the plasma miR-92a level in MM patients could be useful for initiation of chemotherapy and monitoring disease status, and the level may represent, in part, the T-cell immunity status of these patients.

Yoshizawa, S; Ohyashiki, J H; Ohyashiki, M; Umezu, T; Suzuki, K; Inagaki, A; Iida, S; Ohyashiki, K

2012-01-01

312

Compulsive disorders.  

PubMed

Compulsive disorders include a diverse group of conditions characterized by excessive thoughts or preoccupations combined with poorly controlled behaviors. They include trichotillomania, kleptomania, pathologic gambling, compulsive buying disorder, compulsive sexual behavior, and compulsive computer use. Some investigators have suggested that these conditions constitute a spectrum of disorders linked to obsessive-compulsive disorder. Others have questioned the validity of this conceptualization, and have debated the relationship between these disorders. Nevertheless, much has been learned about compulsive disorders, and there have been some successes with psychotherapeutic and psychopharmacologic treatments. Recent therapy-based interventions have moved from psychodynamic treatments toward cognitive-behavioral modalities. Serotonin reuptake inhibitors remain the best-studied pharmacologic treatment, but researchers have also explored other antidepressants, opioid agonists, mood stabilizers, and atypical antipsychotics. PMID:14738707

Kuzma, John M; Black, Donald W

2004-02-01

313

Dissociative Identity Disorder (formerly Multiple Personality Disorder)  

MedlinePLUS

... but to somebody else. In time, such a child may begin to split off alter identities. Research has shown that the average age for the initial development of alters is 5.9 years. Children with DID have a great variety of symptoms, ...

314

Neuropathology of sleep disorders: a review.  

PubMed

Sleep disorders are important manifestations of neurodegenerativediseases and sometimes are clinically evident well before the onset of other neurological manifestations. This review addresses theneuroanatomical basis and the mechanisms of sleep regulation in humans in relation to the neuropathology of entities associated with sleep disturbances in selected diseases, including Alzheimer disease, progressive supranuclear palsy, Lewy body disorders, multiple-system atrophy, and fatal familial insomnia. This includes abnormalities of circadian rhythm, insomnia, narcolepsy, rapid eye movements sleep behavior disorders, and excessive daytime sleepiness. PMID:21412175

Hauw, Jean-Jacques; Hausser-Hauw, Chantal; De Girolami, Umberto; Hasboun, Dominique; Seilhean, Danielle

2011-04-01

315

Pharmacodynamics and safety of ferric carboxymaltose: a multiple-dose study in patients with iron-deficiency anaemia secondary to a gastrointestinal disorder.  

PubMed

This multiple-dose Phase I/II study provided pharmacodynamics and pharmacokinetics data on the therapeutic benefit of ferric carboxymaltose (FCM, Ferinject) and evaluated the safety and tolerability of this intravenous (i.v.) iron preparation. Two doses of iron as FCM were given as i.v. infusion over 15 min, 500 mg iron given once weekly for up to 4 weeks (Cohort 1) or 1000 mg iron weekly for 2 weeks (Cohort 2), in patients with a total requirement > or = 1000 mg iron (total cumulative maximum dose < or = 2000 mg iron). Adults with moderate to severe, stable iron-deficiency anaemia (IDA) (haemoglobin [Hb] < or = 11.0 g/dl, serum ferritin < 100 microg/l, transferrin saturation [TSAT] < 16%) due to a gastrointestinal (GI) disorder were included. Pharmacodynamics variables: proportion of patients achieving values within the reference range for Hb (men: 14.0-18.0 g/dl, women: 12.0-16.0 g/dl), serum ferritin (20-500 microg/l), TSAT (16-45%) and proportion of patients with an increase in Hb of at least 2.0 g/dl. Pharmacokinetics variables: total serum iron levels at time of maximum serum iron concentration during the fast elimination phase and at trough time-points. Safety assessments: the incidence of adverse events (AEs) and changes in vital signs, physical examinations, and clinical laboratory parameters. In Cohorts 1 and 2, 14/20 (70%) versus 19/26 (73%) of patients completed the study. Individual calculated iron deficits were 1000-2100 mg. The mean cumulative dose of FCM in Cohorts 1 and 2 was 1800 mg and 1563 mg iron, respectively. At baseline, patients in both cohorts had similar Hb levels (mean 8.7 g/dl in both cohorts). More than 97% of patients demonstrated a clinically meaningful increase in Hb levels (> or = 1.0 g/dl) during the study. By the week 4 follow-up visit, an increase of at least 2.0 g/dl was achieved by 15/20 (75%) and by 19/26 (73.1%) patients in Cohorts 1 and 2, respectively, and the mean increase in Hb was 3.2 g/dl in Cohort 1 and 3.3 g/dl in Cohort 2. By day 28, 3/6 (50%) patients in Cohort 1 had achieved normal Hb levels, and by the 4-week post-treatment followup visit 7/19 patients (37%) in Cohort 1 and 12/25 (48%) in Cohort 2 had reached Hb levels within the reference range. Serum ferritin levels increased rapidly at the start of treatment and remained in the reference range throughout the study; increases were greater in Cohort 2. Mean baseline TSAT values were similar in both cohorts (24.2% in Cohort 1, 20.7% in Cohort 2), and were within the reference range at the week 4 follow-up visit for 41.0 and 39.1% of the patients in Cohorts 1 and 2, respectively. The incidence of AEs occurring after the first administration of FCM (treatment-emergent AEs, TEAE) was generally low and similar in Cohorts 1 (11/20 [55.0%]) and 2 (13/26 [50.0%]). Most TEAEs were mild; only 2/ 20 patients (10.0%) in Cohort 1 and 3/26 (11.5%) in Cohort 2 had TEAEs of moderate intensity. There were no AEs of severe intensity, serious AEs, or deaths. Most AEs were considered by the investigator to be unrelated or unlikely to be related to the study medication. Since accumulation of serum iron was not observed, a dosing interval of 3-4 days (500 mg iron) or 1 week (1000 mg iron) was demonstrated to be adequate. The increase in serum ferritin and TSAT at the 4-week follow-up visit is indicative of a repletion of the iron stores. The results suggest that doses up to 1000 mg i.v. iron administered as FCM over 15 min arewell tolerated and effective in the treatment of patients with IDA due to a GI disorder. PMID:20648929

Geisser, Peter; Rumyantsev, Vitaly

2010-01-01

316

Heterogeneous ordered-disordered structure of the mesodomain in frozen sucrose-water solutions revealed by multiple electron paramagnetic resonance spectroscopies.  

PubMed

The microscopic structure of frozen aqueous sucrose solutions, over concentrations of 0-75% (w/v), is characterized by using multiple continuous-wave and pulsed electron paramagnetic resonance (EPR) spectroscopic and relaxation techniques and the paramagnetic spin probe, TEMPOL. The temperature dependence of the TEMPOL EPR line-shape anisotropy reveals a mobility transition, specified at 205 K in pure water and 255 ± 5 K for >1% (w/v) added sucrose. The transition temperature is >Tg, where Tg is the homogeneous water glass transition temperature, which shows that TEMPOL resides in the mesoscopic domain (mesodomain) at water-ice crystallite boundaries and that the mesodomain sucrose concentrations are comparable at >1% (w/v) added sucrose. Electron spin-echo envelope modulation (ESEEM) spectroscopy of TEMPOL-(2)H2-sucrose hyperfine interactions also indicates comparable sucrose concentrations in mesodomains at >1% (w/v) added sucrose. Electron spin-echo (ESE) detected longitudinal and phase memory relaxation times (T1 and TM, respectively) at 6 K indicate a general trend of increased mesodomain volume with added sucrose, in three stages: 1-15, 20-50, and >50% (w/v). The calibrated TEMPOL concentrations indicate that the mesodomain volume is less than the predicted maximally freeze-concentrated value [80 (w/w); 120% (w/v)], with transitions at 15-20% and 50% (w/v) starting sucrose. An ordered sucrose hydrate phase, which excludes TEMPOL, and a disordered, amorphous sucrose-water glass phase, in which TEMPOL resides, are proposed to compose a heterogeneous mesodomain. The results show that the ratio of ordered and disordered volume fractions in the mesodomain is exquisitely sensitive to the starting sucrose concentration. PMID:23464733

Chen, Hanlin; Sun, Li; Warncke, Kurt

2013-03-19

317

Chest Injuries and Disorders  

MedlinePLUS

... your neck and your abdomen. It includes the ribs and breastbone. Inside your chest are several organs, ... and collapsed lung Pleural disorders Esophagus disorders Broken ribs Thoracic aortic aneurysms Disorders of the mediastinum, the ...

318

Cytogenetic findings in 200 patients with multiple myeloma  

Microsoft Academic Search

Cytogenetic studies were performed on 200 consecutive patients with multiple myeloma and related disorders. Structurally or numerically abnormal clones were found in 63 patients (32%), including 8 of 45 untreated patients (18%), and 55 of 155 treated patients (35%). The abnormal karyotypes generally showed numerous numerical and structural aberrations and in some patients multiple abnormal clones. The most striking feature

Jeffrey R. Sawyer; James A. Waldron; Sundar Jagannath; Bart Barlogie

1995-01-01

319

Cost estimates of brain disorders in Belgium.  

PubMed

This article presents the data on cost of the major brain disorders in Belgium which were retrieved from "Cost of Disorders of the Brain in Europe" study sponsored by the European Brain Council and performed by Stockholm Health Economics. The disorders selected were: addiction, depression, anxiety disorders, brain tumours, dementia, epilepsy, migraine and other headaches, multiple sclerosis, Parkinson's disease, psychotic disorders, stroke and trauma. Figures for prevalence of disorders and direct medical, direct non-medical and indirect costs are based on data coming from available electronic data bases, or when missing for Belgium, best possible estimates or extrapolated data were used. All economic data were transformed to Euro's for 2004 and adjusted for purchasing power parity (PPP). The results show that the total number of people with any brain disorder in Belgium amounts to 2.9 million in 2004, the most prevalent being anxiety disorders 1.1 million, migraine 860000, addiction (any) 800,000 and depression 500,000 cases. The total cost of all included brain disorders in Belgium was estimated at 10.6 billion Euros. Most costly per case are brain tumours, multiple sclerosis, stroke and dementia. Because of their higher prevalence, however depression, dementia, addiction, anxiety disorders and migraine have the highest total costs. Taken together brain disorders consume 4% of the gross national product and cost each citizen of Belgium 1029 Euros per year. The drug costs for brain disorders constitute only 10% of the total drug market in Belgium, and only 4% of the total cost of brain disorders in Belgium. This should be compared to the cost estimates and to a previous study which showed that brain disorders are responsible for 35% of the total burden of all disorders in Europe. This study suggests therefore that the direct healthcare resources, including expenses for drug therapies, allocated to brain disorders in Belgium are not leveled to the indirect costs and burden of these disorders. A comparison with data available from a direct prospective study in demented Belgian patients suggests that the mathematical estimates presented here reflect quite accurately the real average cost for dementia, although there are large variations depending on disease severity. As, in addition, subjects with brain disorders face collateral costs which have not been taken into associations, a complementary survey in the Belgian ecosystem to establish the cost profile of representative patients for the major brain disorders. Such a survey is being organized by a task force of the Belgian Brain Council. PMID:17323838

Schoenen, Jean; Gianni, Franco; Schretlen, Luc; Sobocki, Patrik

2006-12-01

320

Dissociative Identity Disorder  

ERIC Educational Resources Information Center

Few psychological disorders in the Diagnostic Statistical Manual have generated as much controversy as Dissociative Identity Disorder (DID). For the past 35 years diagnoses of DID, previously referred to as Multiple Personality Disorder (MPD), have increased exponentially, causing various psychological researchers and clinicians to question the…

Schmidt, Tom

2007-01-01

321

Disorderly Light.  

ERIC Educational Resources Information Center

The relationship between theories about electrical conductivity in microscopic wires and laser speckle patterns is described. Practical applications of laser speckle patterns are included. Wave ideas are being used to describe and predict novel phenomena in disordered solids. (KR)

Peterson, Ivars

1991-01-01

322

Cerebellar Disorders  

MedlinePLUS

... hit a tennis ball you are activating the cerebellum. The cerebellum is the area of the brain that controls coordination and balance. Problems with the cerebellum include Cancer Genetic disorders Ataxias - failure of muscle ...

323

Schizoaffective disorder  

MedlinePLUS

... and major mood disorders. These include: Abuse of drugs Problems following medical treatment and therapy Problems due to manic behavior (for example, spending sprees, overly sexual behavior) Suicidal behavior

324

The Off-Label Use of Prazosin for Sleep Disturbances in Noncombat Posttraumatic Stress Disorder  

Microsoft Academic Search

Background: Posttraumatic stress disorder (PTSD) is a form of anxiety disorder that arises after exposure to a traumatic event or stressor. It is characterized by persistent invasive thoughts, emotional detachment, hypervigilance and sleep disturbances. These sleep disturbances include nightmares, insomnia and distressed awakenings and are often refractory to multiple medications, including SSRIs, which are the only FDA approved medication for

DuRoss John D. III

2010-01-01

325

Genetics of bipolar disorder  

PubMed Central

Bipolar disorder (also known as manic depressive illness) is a complex genetic disorder in which the core feature is pathological disturbance in mood (affect) ranging from extreme elation, or mania, to severe depression usually accompanied by disturbances in thinking and behaviour. The lifetime prevalence of 1% is similar in males and females and family, twin, and adoption studies provide robust evidence for a major genetic contribution to risk. There are methodological impediments to precise quantification, but the approximate lifetime risk of bipolar disorder in relatives of a bipolar proband are: monozygotic co-twin 40-70%; first degree relative 5-10%; unrelated person 0.5-1.5%. Occasional families may exist in which a single gene plays the major role in determining susceptibility, but the majority of bipolar disorder involves the interaction of multiple genes (epistasis) or more complex genetic mechanisms (such as dynamic mutation or imprinting). Molecular genetic positional and candidate gene approaches are being used for the genetic dissection of bipolar disorder. No gene has yet been identified but promising findings are emerging. Regions of interest identified in linkage studies include 4p16, 12q23-q24, 16p13, 21q22, and Xq24-q26. Chromosome 18 is also of interest but the findings are confusing with up to three possible regions implicated. To date most candidate gene studies have focused on neurotransmitter systems influenced by medication used in clinical management of the disorder but no robust positive findings have yet emerged. It is, however, almost certain that over the next few years bipolar susceptibility genes will be identified. This will have a major impact on our understanding of disease pathophysiology and will provide important opportunities to investigate the interaction between genetic and environmental factors involved in pathogenesis. This is likely to lead to major improvements in treatment and patient care but will also raise important ethical issues that will need to be addressed.???Keywords: bipolar disorder; manic depressive illness

Craddock, N.; Jones, I.

1999-01-01

326

Pharmacogenetic studies in multiple myeloma  

Microsoft Academic Search

Multiple myeloma (MM) is a malignant plasma cell disorder that accounts for approximately 10%\\u000aof all hematologic cancers.1-2 MM is characterized by clonal proliferation of malignant plasma\\u000acells in the bone marrow, which secrete a homogeneous immunoglobulin product known as\\u000amonoclonal (M) protein or paraprotein. Typical features of MM include osteolytic bone lesions,\\u000arenal disease, anemia, hypercalcemia and immunodeficiency.3\\u000aThe

S. L. Corthals

2011-01-01

327

Recent developments in multiple sclerosis therapeutics  

Microsoft Academic Search

Multiple sclerosis, the most common neurologic disorder of young adults, is traditionally considered to be an inflammatory, autoimmune, demyelinating disease of the central nervous system. Based on this understanding, the initial therapeutic strategies were directed at immune modulation and inflammation control. These approaches, including high-dose corticosteroids for acute relapses and long-term use of parenteral interferon-?, glatiramer acetate or natalizumab for

Rebecca I Spain; Michelle H Cameron; Dennis Bourdette

2009-01-01

328

Clinical Evaluation and Treatment of Multiple Myeloma and Other Monoclonal Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1977-01-01

329

Clinical Evaluation and Treatment of Multiple Myeloma and Other Monoclonal Gammopathies.  

National Technical Information Service (NTIS)

The Cancergram concerns the clinical aspects of multiple myeloma and related disorders, including macroglobulinemia, light-chain disease, heavy-chain disease, amyloidosis, the monoclonal gammopathies, and other dysproteinemias. Because of coverage by othe...

1978-01-01

330

A proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transporter gene.  

PubMed

Expression of the norepinephrine transporter (NET), which mediates the reuptake of norepinephrine into presynaptic nerve terminals, is restricted to noradrenergic (NA) neurons. We have demonstrated previously that the 9.0 kb upstream sequences and the first intron residing in the 5' untranslated area are critical for high-level and NA cell-specific transcription. Here, using transient transfection assays, we show that 4.0 kb of the 5' upstream sequences contains sufficient genetic information to drive reporter gene expression in an NA cell type-specific manner. Three functional domains appear to be potentially important for the regulation of human NET (hNET) gene transcription: an upstream enhancer region at -4.0 to -3.1 kb, a proximal domain at -133 to -75 bp, and a middle silencer region between these two domains. DNase I footprinting analysis of the proximal promoter region shows that a subdomain at -128 to -80 bp is protected in a cell-specific manner. We provide evidence that multiple protein factors interact with the proximal promoter domain to critically regulate the transcriptional activity of the hNET gene. In the middle of this proximal subdomain resides a homeodomain (HD)-binding core motif, which interacts with HD factors, including Phox2a and HoxA5, in an NA-specific manner. Cotransfection analyses suggest that HoxA5 and Phox2a may transactivate the hNET gene promoter. Together with previous studies indicating direct activation of dopamine beta-hydroxylase transcription by Phox2a/2b, the present results support a model whereby Phox2 proteins may coordinately regulate the phenotypic specification of NA neurons by activating both NA biosynthetic and reuptake genes. PMID:11923423

Kim, Chun-Hyung; Hwang, Dong-Youn; Park, Jae-Joon; Kim, Kwang-Soo

2002-04-01

331

Lactic acidosis and mitochondrial disorders.  

PubMed

Characterization of the biochemical basis of various inherited disorders associated with lactic acidosis has increased dramatically in recent years. These include defects of enzymes of gluconeogenesis, pyruvate oxidation, and electron transport. Clinical manifestations of these disorders show great variation and overlap, frequently involving the central nervous system as well as skeletal and cardiac muscle. Several of these enzymes are large complexes of subunits encoded by multiple genes; the electron transport chain complexes include subunits encoded by both nuclear and mitochondrial genes. This great complexity complicates analysis of specific mutations, despite considerable progress in defining the primary structure of component proteins and their genes. With few exceptions, treatment of disorders associated with congenital lactic acidosis remains unsatisfactory. PMID:1959224

Kerr, D S

1991-08-01

332

Pediatric psychocutaneous disorders: a review of primary psychiatric disorders with dermatologic manifestations.  

PubMed

Psychocutaneous disorders (PCDs) are conditions that are characterized by psychiatric and skin manifestations. Classifications of PCDs and their nomenclature are matters of debate. For the purpose of this review, we adopted the classification that distinguishes primary dermatologic disorders with psychiatric co-morbidity (PDDPC) from primary psychiatric disorders with dermatologic manifestations (PPDDM). PDDPC includes the psychophysiologic disorders such as atopic eczema, psoriasis, vitiligo, and alopecia areata. PPDDM includes impulse control disorders, obsessive-compulsive disorders, factitious disorder, factitious disorder by proxy, self-mutilation, delusions of parasitosis, psychogenic purpura/Gardner-Diamond syndrome, and cutaneous sensory disorders. Diagnosis and treatment of PCDs are challenging and require that the underlying psychopathology be addressed. A specific PCD may have different underlying psychopathologies and, at times, multiple overlapping psychopathologies may coexist. Most often, both non-pharmacologic management and psychopharmacologic treatment are necessary. The choice of psychopharmacologic agent depends on the nature of the underlying psychopathology (e.g. anxiety, depression, obsessive-compulsive disorder, psychosis). This article reviews the spectrum of PPDDM in children. PMID:21548659

Al Hawsawi, Khalid; Pope, Elena

2011-08-01

333

Recommendations for including multiple symptoms as endpoints in cancer clinical trials: a report from the ASCPRO (Assessing the Symptoms of Cancer Using Patient-Reported Outcomes) Multisymptom Task Force.  

PubMed

The multiple symptoms arising from cancer and its treatment impose significant distress for patients. However, in clinical research, there is no agreed-upon way of assessing and presenting the effects of treatment on multiple symptoms, as either individual scores or a composite score. The ASCPRO (Assessing the Symptoms of Cancer Using Patient-Reported Outcomes) Multisymptom Task Force was established to make recommendations about measuring multiple symptoms as outcomes in cancer clinical trials. The Multisymptom Task Force addressed how to choose the symptoms to be assessed and how multiple individual symptom scores or composite scores of several symptoms might be used as clinical trial outcomes. Consensus was reached on a definition of a multisymptom outcome, the problem of source attribution, and the need for a hypothesis-driven conceptual framework to measure multisymptom outcomes. Validated single-item and multi-item measures currently available or that can be easily generated for oncology use were deemed sufficient for measuring multiple symptoms. The relative value of a composite score versus a set of individual symptom scores was discussed, along with issues in developing and deploying such a composite measure. The results indicated that more research on combining scores of different symptoms is needed. Symptom data should be a required component of cancer clinical trials. Patient-reported symptoms provide a unique patient perspective on treatment benefit and risk that goes beyond clinician-reported adverse events. A representation of changes in multiple symptoms would clarify the impact of treatment and enhance the interpretation of cancer clinical trials for clinicians, patients, and those who make health care policy. PMID:22930243

Cleeland, Charles S; Sloan, Jeff A; Cella, David; Chen, Connie; Dueck, Amylou C; Janjan, Nora A; Liepa, Astra M; Mallick, Rajiv; O'Mara, Ann; Pearson, Jay D; Torigoe, Yasuhiro; Wang, Xin Shelley; Williams, Loretta A; Woodruff, Jeanie F

2012-08-28

334

Disordered photonics  

NASA Astrophysics Data System (ADS)

What do lotus flowers have in common with human bones, liquid crystals with colloidal suspensions, and white beetles with the beautiful stones of the Taj Mahal? The answer is they all feature disordered structures that strongly scatter light, in which light waves entering the material are scattered several times before exiting in random directions. These randomly distributed rays interfere with each other, leading to interesting, and sometimes unexpected, physical phenomena. This Review describes the physics behind the optical properties of disordered structures and how knowledge of multiple light scattering can be used to develop new applications. The field of disordered photonics has grown immensely over the past decade, ranging from investigations into fundamental topics such as Anderson localization and other transport phenomena, to applications in imaging, random lasing and solar energy.

Wiersma, Diederik S.

2013-03-01

335

Genetics of bipolar disorder.  

PubMed

Bipolar disorder (also known as manic depressive illness) is a complex genetic disorder in which the core feature is pathological disturbance in mood (affect) ranging from extreme elation, or mania, to severe depression usually accompanied by disturbances in thinking and behaviour. The lifetime prevalence of 1% is similar in males and females and family, twin, and adoption studies provide robust evidence for a major genetic contribution to risk. There are methodological impediments to precise quantification, but the approximate lifetime risk of bipolar disorder in relatives of a bipolar proband are: monozygotic co-twin 40-70%; first degree relative 5-10%; unrelated person 0.5-1.5%. Occasional families may exist in which a single gene plays the major role in determining susceptibility, but the majority of bipolar disorder involves the interaction of multiple genes (epistasis) or more complex genetic mechanisms (such as dynamic mutation or imprinting). Molecular genetic positional and candidate gene approaches are being used for the genetic dissection of bipolar disorder. No gene has yet been identified but promising findings are emerging. Regions of interest identified in linkage studies include 4p16, 12q23-q24, 16p13, 21q22, and Xq24-q26. Chromosome 18 is also of interest but the findings are confusing with up to three possible regions implicated. To date most candidate gene studies have focused on neurotransmitter systems influenced by medication used in clinical management of the disorder but no robust positive findings have yet emerged. It is, however, almost certain that over the next few years bipolar susceptibility genes will be identified. This will have a major impact on our understanding of disease pathophysiology and will provide important opportunities to investigate the interaction between genetic and environmental factors involved in pathogenesis. This is likely to lead to major improvements in treatment and patient care but will also raise important ethical issues that will need to be addressed. PMID:10465107

Craddock, N; Jones, I

1999-08-01

336

Bipolar disorder: diagnostic issues  

Microsoft Academic Search

Bipolar disorders are cyclical mood disorders with clinical features including distinct sustained periods of mood elevation. • Briefer (4 days or more), mild episodes of mood elevation define bipolar II disorder; lengthier (7 days or more), more severe episodes (or those requiring hospitalisation), with or without psychotic features, define bipolar I disorder. • Depressive periods are more common and lengthier

John W G Tiller; Isaac Schweitzer

2010-01-01

337

Causes of bulimic disorders  

Microsoft Academic Search

Understanding the causes of bulimia nervosa and the atypical bulimic disorders (including binge eating disorder) allows us to formulate such cases, and aids in planning treatment. This article outlines the risk factors for bulimic disorders, such as genetics, family function, and media exposure. It describes the cognitions that serve as long-term antecedents to the development of eating disorders, and the

Glenn Waller; Alexandra Sheffield

2008-01-01

338

Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I.  

PubMed

Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. PMID:12145749

Takahara, Kazuhiko; Schwarze, Ulrike; Imamura, Yasutada; Hoffman, Guy G; Toriello, Helga; Smith, Lynne T; Byers, Peter H; Greenspan, Daniel S

2002-07-17

339

Development of a universal psycho-educational intervention to prevent common postpartum mental disorders in primiparous women: a multiple method approach  

Microsoft Academic Search

BACKGROUND: Prevention of postnatal mental disorders in women is an important component of comprehensive health service delivery because of the substantial potential benefits for population health. However, diverse approaches to prevention of postnatal depression have had limited success, possibly because anxiety and adjustment disorders are also problematic, mental health problems are multifactorially determined, and because relationships amongst psychosocial risk factors

Heather J Rowe; Jane RW Fisher

2010-01-01

340

A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder: suggesting multiple susceptibility genes among Chinese Han population  

Microsoft Academic Search

Attention deficit hyperactivity disorder (ADHD) is a common childhood-onset behavioral disorder with a definite genetic component. The search for genes predisposing to ADHD has focused on genes involved in the regulation of monoamine systems. In this study, we emphasized genes that underlie various aspects of dopamine, norepinephrine and serotonin neurotransmissions and performed a comprehensive association analysis by screening with 245

L Guan; B Wang; Y Chen; L Yang; J Li; Q Qian; Z Wang; S V Faraone; Y Wang

2009-01-01

341

Aggregation of lifetime Axis I psychiatric disorders through age 30: incidence, predictors, and associated psychosocial outcomes.  

PubMed

Longitudinal data from representative birth cohorts on the aggregation of psychiatric disorders, or the cumulative number of unique diagnosed disorders experienced by persons within a circumscribed period, are limited. As a consequence, risk factors for and psychosocial implications of lifetime disorder aggregation in the general population remain largely unknown. This research evaluates the incidence, predictors, and psychosocial sequela of lifetime disorder aggregation from childhood through age 30. Over a 14-year period, participants in the Oregon Adolescent Depression Project (probands; N = 816) were repeatedly evaluated for psychiatric disorders and assessed with multiple measures of psychosocial functioning. First-degree relatives of probands (N = 2,414) were also interviewed to establish their lifetime psychiatric history. The cumulative prevalence of common lifetime psychiatric disorders for the proband sample was 71%. Three-quarters of all proband psychiatric disorders occurred among 37% of the sample, and 82% of all disorder diagnoses were made among persons who met criteria for at least one other lifetime disorder. Lifetime disorder aggregation in probands was predicted by lifetime psychiatric disorder densities among first-degree relatives and was related to heterotypic comorbidity patterns that included disorders from both internalizing and externalizing domains, most notably major depressive and alcohol use disorders. By age 30, disorder aggregation was significantly associated with mental health care service utilization and predictive of personality disorder pathology and numerous indicators of poor psychosocial functioning. Possible implications of disorder aggregation on the conceptualization of lifetime psychiatric disorder comorbidity are discussed. PMID:23421525

Farmer, Richard F; Kosty, Derek B; Seeley, John R; Olino, Thomas M; Lewinsohn, Peter M

2013-02-18

342

Barriers to effective diagnosis and management of a bleeding patient with undiagnosed bleeding disorder across multiple specialties: results of a quantitative case-based survey  

PubMed Central

Background: Bleeding symptoms commonly seen by multiple physician specialties may belie undiagnosed congenital or acquired bleeding disorders. Acquired hemophilia is a potentially life-threatening cause of unexplained acute bleeding manifested by an abnormal activated partial thromboplastin time (aPTT) that does not correct with 1:1 mixing with normal plasma. Methods: Practicing physicians (hematology/oncology, emergency medicine, geriatrics, internal medicine, rheumatology, obstetrics and gynecology, critical care medicine, and general surgery) completed an online survey based on a hypothetical case scenario. Results: Excluding surgeons and obstetrician/gynecologist respondents, 302 physicians (about 50 per specialty) were presented with an older adult woman complaining of recurrent epistaxis. Nearly 90% ordered a complete blood count and coagulation studies (aPTT, prothrombin time [PT]/international normalized ratio [INR]). Despite a prolonged aPTT of 42 seconds, <50% of nonhematologists would repeat the aPTT, and <45% would consult a hematologist; emergency medicine physicians were least likely (10%) and rheumatologists were most likely (43%) to consult. After presentation weeks later with bruising and abdominal/back pain, ?90% of physicians within each specialty ordered a complete blood count or PT/INR/aPTT. Despite an aPTT of 63 seconds, the majority did not repeat the aPTT. At this point, approximately 75% of internal medicine and geriatric physicians indicated they would consult a hematologist, versus 47% in emergency medicine and 50% in critical care. All participants preferred abdominal computed tomography (80%–84%). After 12 hours of additional observation, 73% to 94% of respondents consulted a hematologist. Complete blood count revealed anemia and an aPTT twice the upper limit of normal; emergency medicine physicians remained least likely to request a consult. Conclusion: Determining the cause of an abnormal coagulation study result should carry equal weight as looking for the site of bleeding and could be facilitated by consultation with a hematologist. Insight from this survey highlights knowledge and practice gaps that could be the target of focused educational initiatives.

Reding, Mark T; Cooper, David L

2012-01-01

343

Epilepsy Associated with Systemic Autoimmune Disorders  

PubMed Central

Systemic autoimmune disorders affect multiple organ systems. Brain involvement commonly causes seizures, which may be the presenting symptom. Systemic lupus erythematosus, Sjorgren's syndrome, Wegener's granulomatosis, sarcoidsosis, celiac disease, Crohn's disease, Behcet's, and Hashimoto's encephalopathy are reviewed. Mechanisms underlying CNS pathology in systemic autoimmune disorders—and specifically factors predisposing these patients—are discussed, including vascular disease (e.g., prothrombotic state, anticardiolipin antibody, emboli, vasculitis), antineuronal antibodies, immune complexes, cytokines, metabolic disorders, infection, and therapy. Diagnostic and therapeutic strategies must be individualized for both the disorder and the patient. Systemic autoimmune disorders affect multiple organ systems and frequently involve the central and peripheral nervous systems. Seizures are among the most common neurological manifestation and occasionally can be the presenting symptom. There are many causes of seizures in systemic autoimmune disorders (Table 1), and the first clinical challenge is to determine not only the cause but also the significance of seizures. In some cases, they are clues to metabolic or infectious disorders or medication toxicity; in other cases, seizures herald a life-threatening progression of the underlying illness.

Devinsky, Orrin; Schein, Adam; Najjar, Souhel

2013-01-01

344

Successful management of cryoglobulinemia-induced leukocytoclastic vasculitis with thalidomide in a patient with multiple myeloma  

Microsoft Academic Search

Leukocytoclastic vasculitis (LV) is a systemic inflammatory disorder involving mostly the small vessels. It is characterised by segmental angiocentric neutrophilic inflammation, endothelial cell damage and fibrinoid necrosis. LV is related to a variety of clinical disorders including cryoglobulinemia and, very rarely, multiple myeloma (MM), among many others. The development of LV in patients with MM has been linked to cryoglobulinemia,

M. Cem Ar; Teoman Soysal; Gulen Hatemi; Ayse Salihoglu; Hasan Yazici; Birsen Ulku

2005-01-01

345

An Ecosystemic Perspective in the Treatment of Posttraumatic Stress and Substance Use Disorders in Veterans  

Microsoft Academic Search

This article reviews the prevalence of co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) in the veteran population. Recommendations regarding how to better understand, engage, and retain veterans with PTSD\\/SUDs in treatment are presented through an ecological perspective that takes into account the multiple systems and worldviews, including culture, ethnicity, family, and military culture, that are transacting with

Eugenia L. Weiss; Jose E. Coll; Shannon Mayeda; Jennifer Mascarenas; Kristen Lawlor; Tara Debraber

2012-01-01

346

Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders  

Microsoft Academic Search

The concept of the gut forming the centre of an integrated gut–brain–energy axis — modulating appetite, metabolism and digestion — opens up new paradigms for drugs that can tackle multiple symptoms in complex upper gastrointestinal disorders. These include eating disorders, nausea and vomiting, gastroesophageal reflux disease, gastroparesis, dyspepsia and irritable bowel syndrome. The hormones that modulate gastric motility represent targets

Kevin Lee; Gareth J. Sanger

2008-01-01

347

Peer Victimization in Youth with Tourette Syndrome and Other Chronic Tic Disorders  

ERIC Educational Resources Information Center

|Chronic tic disorders including Tourette syndrome have negative impact across multiple functional domains. We explored associations between peer victimization status and tic subtypes, premonitory urges, internalizing symptoms, explosive outbursts, and quality of life among youth with chronic tic disorders, as part of the internet-based omnibus…

Zinner, Samuel H.; Conelea, Christine A.; Glew, Gwen M.; Woods, Douglas W.; Budman, Cathy L.

2012-01-01

348

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities  

Microsoft Academic Search

BACKGROUND: The pharmacological treatment of bipolar disorder has dramatically improved with multiple classes of agents being used as mood-stabilizers, including lithium, anticonvulsants, and atypical antipsychotics. However, the use of these medications is not without risk, particularly when a patient with bipolar disorder also has comorbid medical illness. As the physician who likely has the most contact with patients with bipolar

Kimberly D McLaren; Lauren B Marangell

2004-01-01

349

Oppositional Defiant and Conduct Disorder Behaviors in Boys With Autism Spectrum Disorder With and Without Attention-Deficit Hyperactivity Disorder Versus Several Comparison Samples  

Microsoft Academic Search

We compared disruptive behaviors in boys with either autism spectrum disorder (ASD) plus ADHD (n = 74), chronic multiple tic disorder plus ADHD (n = 47), ADHD Only (n = 59), or ASD Only (n = 107). Children were evaluated with parent and teacher versions of the Child Symptom Inventory-4 including parent- (n = 168) and teacher-rated (n = 173) community controls. Parents rated children in the three ADHD groups comparably for

Sarit Guttmann-Steinmetz; Kenneth D. Gadow; Carla J. DeVincent

2009-01-01

350

Autism and Developmental Disabilities Monitoring Network, 2012. Prevalence of Autism Spectrum Disorders (ASDs) Among Multiple Areas of the United States in 2008.  

National Technical Information Service (NTIS)

The Centers for Disease Control and Prevention (CDC) estimates that about 1 in 88 children has been identified with an autism spectrum disorder (ASD). CDCs estimate comes from the Autism and Developmental Disabilities Monitoring (ADDM) Network, which moni...

2012-01-01

351

Quality of life in multiple sclerosis patients with urinary disorders: reliability and validity of the Turkish version of King's Health Questionnaire.  

PubMed

MS patients frequently present with urinary system symptoms, which have a negative effect on the quality life. The aim of our study was to demonstrate the validity and reliability of the Turkish King's Health Questionnaire (KHQ) in MS patients. The study included 37 patients. For analysis of test-retest reliability, the Turkish version of the KHQ developed and the "translation-back translation" method was performed. To assess the validity of these results, Multiple Sclerosis Quality of Life Scale (MQoL-54) and Expanded Disability Status Scale (EDSS) were used. The internal consistency (intra-class correlation coefficient: 0.59-0.94) and test-retest reliability (Cronbach's ?-score 0.59-0.94) of KHQ were found to be high (p < 0.05). A significant correlation was detected between most of the KHQ subscores and the physical and mental MQoL-54 and EDSS (total and bowel/bladder, p < 0.05) subscores. The KHQ may be used to determine the effect of incontinence on the quality of life for MS patients. PMID:21479614

Akkoc, Ye?im; Karapolat, Hale; Eyigor, Sibel; Yesil, Hilal; Yüceyar, Nur

2011-04-09

352

Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation.  

PubMed

Iron abnormalities within the brain are associated with several rare but severe neurodegenerative conditions. There is growing evidence that more common systemic iron loading disorders such as hemochromatosis can also have important effects on the brain. To identify features that are common across different forms of hemochromatosis, we used microarray and real-time reverse transcription polymerase chain reaction (RT-PCR) to assess brain transcriptome profiles of transferrin receptor 2 mutant mice (Tfr2(mut)), a model of a rare type of hereditary hemochromatosis, relative to wildtype control mice. The results were compared with our previous findings in dietary iron-supplemented wildtype mice and Hfe(-/-) mice, a model of a common type of hereditary hemochromatosis. For transcripts showing significant changes relative to controls across all three models, there was perfect (100%) directional concordance (i.e. transcripts were increased in all models or decreased in all models). Comparison of the two models of hereditary hemochromatosis, which showed more pronounced changes than the dietary iron-supplemented mice, revealed numerous common molecular effects. Pathway analyses highlighted changes for genes relating to long-term depression (6.8-fold enrichment, p=5.4×10(-7)) and, to a lesser extent, long-term potentiation (3.7-fold enrichment, p=0.01), with generalized reductions in transcription of key genes from these pathways, which are involved in modulating synaptic strength and efficacy and are essential for memory and learning. The agreement across the models suggests the findings are robust and strengthens previous evidence that iron loading disorders affect the brain. Perturbations of brain phenomena such as long-term depression and long-term potentiation might partly explain neurologic symptoms reported for some hemochromatosis patients. PMID:23333676

Acikyol, B; Graham, R M; Trinder, D; House, M J; Olynyk, J K; Scott, R J; Milward, E A; Johnstone, D M

2013-01-16

353

Sleep disorders - overview  

MedlinePLUS

Sleep disorders are problems with sleeping, including trouble falling or staying asleep, falling asleep at the wrong times, ... low thyroid function Mononucleosis or other viral illnesses Narcolepsy and other sleep disorders Obesity, especially if it ...

354

Peroxisomal disorders.  

PubMed

The peroxisomal disorders represent a group of genetic diseases in man in which there is an impairment in one or more peroxisomal functions. The peroxisomal disorders are subdivided into three subgroups comprising: (1) the peroxisome biogenesis disorders (PBDs); (2) the single peroxisomal (enzyme-) protein deficiencies; and (3) the single peroxisomal substrate transport deficiencies. The PBD group comprises four different disorders that include Zellweger syndrome (ZS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and rhizomelic chondrodysplasia punctata (RCDP). ZS, NALD, and IRD are clearly distinct from RCDP and are usually referred to as the Zellweger spectrum with ZS being the most severe, and IRD the less severe disorder, with sometimes onset in adulthood. The single peroxisomal enzyme deficiency group comprises seven different disorders, of which D-bifunctional protein and phytanoyl-CoA hydroxylase (adult Refsum disease) deficiencies are the most frequent. The single peroxisomal substrate transport deficiency group consists of only one disease, X-linked adrenoleukodystrophy. It is the purpose of this chapter to describe the current state of knowledge about the clinical, biochemical, cellular, and molecular aspects of peroxisomal diseases, and to provide guidelines for their post- and prenatal diagnosis. Therapeutic interventions are mostly limited to X-linked adrenoleukodystrophy. PMID:23622381

Aubourg, Patrick; Wanders, Ronald

2013-01-01

355

Cross-species models of OCD spectrum disorders  

Microsoft Academic Search

Several axis-I neuropsychiatric disorders are characterised by repetitive motor habits suggestive of underlying inhibitory dyscontrol, and may constitute members of a putative obsessive–compulsive (OC) spectrum. Notable examples include obsessive–compulsive disorder (OCD) and trichotillomania (repetitive hair-pulling). Multiple tiers of evidence link these conditions with underlying dysregulation of fronto-striatal circuitry and monoamine systems. These abnormalities represent key targets for existing and novel

Vasileios Boulougouris; Samuel R. Chamberlain; Trevor W. Robbins

2009-01-01

356

Eating Disorders  

MedlinePLUS

... Submit Home > Body Image > Eating disorders Body Image Eating disorders About eating disorders Over-exercising More information on eating disorders About eating disorders "Mirror, Mirror on the wall...who's the thinnest ...

357

Loneliness and eating disorders.  

PubMed

This article examines the link between loneliness and eating disorders. This concept is evaluated through a systematic review of the literature that links loneliness and eating disorders and through a survey of themes connecting the 2 conditions. Eating disorders-including anorexia nervosa, bulimia nervosa, and eating disorders that are not otherwise specified, which include binge eating disorder-are challenging health issues. Each of these diagnoses specifically relates to loneliness. This negative emotion contributes to and fuels eating disorder symptoms. Negative interpersonal relationships, both real experiences and individuals' skewed perceptions, exacerbate eating disorders and feelings of loneliness. Characteristics that have been associated with loneliness clearly relate to eating disorders. Understanding this relationship is vital, so that we can appreciate our patients' struggles and work to target these intense emotions within the treatment setting. We need to be aware of the power of loneliness as it applies to individuals in general and specifically to those struggling with disordered eating. PMID:22303623

Levine, Martha Peaslee

358

Relationships Among Suicide Ideators, Attempters, and Multiple Attempters in a Young-Adult Sample  

Microsoft Academic Search

The relationships among suicide ideators, attempters, and multiple attempters were explored in 332 psychiatric patients referred specifically for suicidal ideation or behavior. Previous researchers have subsumed multiple attempters under the general category of attempters. However, comparisons across a range of variables, including Axis I diagnoses from the revised 3rd edition of the Diagnostic and Statistical Manual of Mental Disorders (American

M. David Rudd; Thomas Joiner; M. Hasan Rajab

1996-01-01

359

Sexuality in multiple sclerosis  

Microsoft Academic Search

Summary. Sexuality and partnership have an important influence on the quality of life of every person and also on people with chronic disorders such as multiple sclerosis. The findings in literature show high evidence that people with multiple sclerosis experience high levels of sexual dysfunction, most of them with hypoactive sexual behaviour often associated with dissatisfaction in relationship, and also

E. Z. Schmidt; P. Hofmann; G. Niederwieser; H.-P. Kapfhammer; R. M. Bonelli

2005-01-01

360

Meeting the needs of clients with dissociative identity disorder: considerations for psychotherapy  

Microsoft Academic Search

Psychotherapy for clients with Dissociative Identity Disorder (DID) is different to therapy with most clients because these clients are multiple, comprising one or more host, and one or more alter personalities. The necessary components to be addressed in order that clients can live successfully either as a multiple or as an integrated person are outlined, discussed and critiqued. These include

Jo L. Ringrose

2011-01-01

361

EAAT2 regulation and splicing: relevance to psychiatric and neurological disorders  

Microsoft Academic Search

The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate uptake in the brain and its dysregulation has been associated with multiple psychiatric and neurological disorders. However, investigation of this molecule has been complicated by its complex pattern of alternative splicing, including three coding isoforms and multiple 5?- and 3?-UTRs that may have a regulatory function.

T L Lauriat; L A McInnes

2007-01-01

362

Neurodegenerative disorders and nanoformulated drug development  

PubMed Central

Degenerative and inflammatory diseases of the CNS include, but are not limited to, Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, stroke, multiple sclerosis and HIV-1-associated neurocognitive disorders. These are common, debilitating and, unfortunately, hold few therapeutic options. In recent years, the application of nanotechnologies as commonly used or developing medicines has served to improve pharmacokinetics and drug delivery specifically to CNS-diseased areas. In addition, nanomedical advances are leading to therapies that target CNS pathobiology and as such, can interrupt disordered protein aggregation, deliver functional neuroprotective proteins and alter the oxidant state of affected neural tissues. This article focuses on the pathobiology of common neurodegenerative disorders with a view towards how nanomedicine may be used to improve the clinical course of neurodegenerative disorders.

Nowacek, Ari; Kosloski, Lisa M; Gendelman, Howard E

2009-01-01

363

The relationship between creativity and mood disorders  

PubMed Central

Research designed to examine the relationship between creativity and mental illnesses must confront multiple challenges. What is the optimal sample to study? How should creativity be defined? What is the most appropriate comparison group? Only a limited number of studies have examined highly creative individuals using personal interviews and a noncreative comparison group. The majority of these have examined writers. The preponderance of the evidence suggests that in these creative individuals the rate of mood disorder is high, and that both bipolar disorder and unipolar depression are quite common. Clinicians who treat creative individuals with mood disorders must also confronta variety of challenges, including the fear that treatment may diminish creativity, in the case of bipolar disorder, hovt/ever, it is likely that reducing severe manic episodes may actually enhance creativity in many individuals.

Andreasen, Nancy C.

2008-01-01

364

Traumatic Brain Injury and Sleep Disorders  

PubMed Central

SYNOPSIS Sleep disturbance is common following traumatic brain injury (TBI), affecting 30–70% of individuals, many occurring after mild injuries. Insomnia, fatigue and sleepiness are the most frequent post-TBI sleep complaints with narcolepsy (with or without cataplexy), sleep apnea (obstructive and/or central), periodic limb movement disorder, and parasomnias occurring less commonly. In addition, depression, anxiety and pain are common TBI co-morbidities with substantial influence on sleep quality. Two types of TBI negatively impact sleep: contact injuries causing focal brain damage and acceleration/deceleration injuries causing more generalized brain damage. Diagnosis of sleep disorders after TBI may involve polysomnography, multiple sleep latency testing and/or actigraphy. Treatment is disorder specific and may include the use of medications, continuous positive airway pressure (or similar device) and/or behavioral modifications. Unfortunately, treatment of sleep disorders associated with TBI often does not improve sleepiness or neuropsychological function.

Viola-Saltzman, Mari; Watson, Nathaniel F.

2012-01-01

365

Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance  

PubMed Central

Despite improved outcomes in multiple myeloma (MM), a cure remains elusive. However, even before the current therapeutic era, 5% of patients survived >10 years and we propose that immune factors contribute to this longer survival. We identified patients attending our clinic, who had survived >10 years (n=20) and analysed their blood for the presence of T-cell clones, T-regulatory cells (Tregs) and T helper 17 (Th17) cells. These results were compared with MM patients with shorter follow-up and age-matched healthy control donors. The frequency of cytotoxic T-cell clonal expansions in patients with <10 years follow-up (MM patients) was 54% (n=144), whereas it was 100% (n=19/19) in the long-survivors (LTS-MM). T-cell clones from MM patients proliferated poorly in vitro, whereas those from LTS-MM patients proliferated readily (median proliferations 6.1% and 61.5%, respectively (P<0.0001)). In addition, we found significantly higher Th17 cells and lower Tregs in the LTS-MM group when compared with the MM group. These results indicate that long-term survival in MM is associated with a distinct immunological profile, which is consistent with decreased immune suppression.

Bryant, C; Suen, H; Brown, R; Yang, S; Favaloro, J; Aklilu, E; Gibson, J; Ho, P J; Iland, H; Fromm, P; Woodland, N; Nassif, N; Hart, D; Joshua, D E

2013-01-01

366

The Single and Combined Effects of Multiple Intensities of Behavior Modification and Methylphenidate for Children with Attention Deficit Hyperactivity Disorder in a Classroom Setting  

ERIC Educational Resources Information Center

|Currently behavior modification, stimulant medication, and combined treatments are supported as evidence-based interventions for attention deficit hyperactivity disorder in classroom settings. However, there has been little study of the relative effects of these two modalities and their combination in classrooms. Using a within-subject design,…

Fabiano, Gregory A.; Pelham, William E., Jr.; Gnagy, Elizabeth M.; Burrows-MacLean, Lisa; Coles, Erika K.; Chacko, Anil; Wymbs, Brian T.; Walker, Kathryn S.; Arnold, Fran; Garefino, Allison; Keenan, Jenna K.; Onyango, Adia N.; Hoffman, Martin T.; Massetti, Greta M.; Robb, Jessica A.

2007-01-01

367

Integrating Case Topics in Medical School Curriculum to Enhance Multiple Skill Learning: Using Fetal Alcohol Spectrum Disorders as an Exemplary Case  

ERIC Educational Resources Information Center

|Objectives: This article describes the use of fetal alcohol spectrum disorders (FASDs) as a theme to connect the learning of basic neurosciences with clinical applications across the age span within a systems-based, integrated curricular structure that emphasizes problem-based learning. Methods: In collaboration with the Centers for Disease…

Paley, Blair; O'Connor, Mary J.; Baillie, Susan J.; Guiton, Gretchen; Stuber, Margaret L.

2009-01-01

368

Community Report from the Autism and Developmental Disabilities Monitoring (ADDM) Network: Prevalence of Autism Spectrum Disorders (ASDs) among Multiple Areas of the United States in 2008  

ERIC Educational Resources Information Center

|The Centers for Disease Control and Prevention (CDC) estimates that about 1 in 88 children has been identified with an autism spectrum disorder (ASD). CDC's estimate comes from the Autism and Developmental Disabilities Monitoring (ADDM) Network, which monitors the number of 8-year-old children with ASDs living in diverse communities throughout…

Centers for Disease Control and Prevention, 2012

2012-01-01

369

Multiple List Learning in Adults with Autism Spectrum Disorder: Parallels with Frontal Lobe Damage or Further Evidence of Diminished Relational Processing?  

ERIC Educational Resources Information Center

|To test the effects of providing relational cues at encoding and/or retrieval on multi-trial, multi-list free recall in adults with high-functioning autism spectrum disorder (ASD), 16 adults with ASD and 16 matched typical adults learned a first followed by a second categorised list of 24 words. Category labels were provided at encoding,…

Bowler, Dermot M.; Gaigg, Sebastian B.; Gardiner, John M.

2010-01-01

370

The Single and Combined Effects of Multiple Intensities of Behavior Modification and Methylphenidate for Children With Attention Deficit Hyperactivity Disorder in a Classroom Setting  

Microsoft Academic Search

Currently behavior modification, stimulant medication, and combined treatments are supported as evidence-based interventions for attention deficit hyper- activity disorder in classroom settings. However, there has been little study of the relative effects of these two modalities and their combination in classrooms. Using a within-subject design, the present study investigated the single effects of behavior modification (no, low, and high intensity),

Gregory A. Fabiano; William E. Pelham; Elizabeth M. Gnagy; Lisa Burrows-MacLean; Erika K. Coles; Anil Chacko; Brian T. Wymbs; Kathryn S. Walker; Fran Arnold; Allison Garefino; Jenna K. Keenan; Adia N. Onyango; Martin T. Hoffman; Greta M. Massetti; Jessica A. Robb

371

Trousseau's syndrome: multiple definitions and multiple mechanisms  

PubMed Central

In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. In recent times the term has been ascribed to various clinical situations, ranging all the way from these classic descriptions to any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syndrome are partly the consequence of multiple pathophysiologic mechanisms that apparently contribute to the hypercoagulability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. Also considered here are recent hypotheses about genetic pathways within tumor cells that might trigger these thrombotic phenomena, and the reasons why therapy with heparins of various kinds remain the preferred treatment, probably because of their salutary actions on several of the proposed pathologic mechanisms.

2007-01-01

372

Interstitial deletion of chromosome 9, int del(9)(9q22.31-q31.2), including the genes causing multiple basal cell nevus syndrome and Robinow\\/brachydactyly 1 syndrome  

Microsoft Academic Search

We report a child with a de novo interstitial deletion, 46,XY, int del(9)(9q22.31-q31.2). Cytogenetic and molecular analysis defined the boundaries of the lost region, of paternal origin, from D9S1796 to D9S938. The clinical picture included macrocephaly, frontal bossing, bilateral epicanthus, down-slanted palpebral fissures, low-set ears, hypoplastic nostrils, micrognathia, scoliosis, right single palmar crease, small nails, slender fingers, bilaterally flexed 5th

Carla Olivieri; Paola Maraschio; Desiree Caselli; Carla Martini; Giampiero Beluffi; Emanuela Maserati; Cesare Danesino

2003-01-01

373

Differences in the Nature of Body Image Disturbances between Female Obese Individuals with versus without a Comorbid Binge Eating Disorder: An Exploratory Study Including Static and Dynamic Aspects of Body Image  

ERIC Educational Resources Information Center

|Various components of body image were measured to assess body image disturbances in patients with obesity. To overcome limitations of previous studies, a photo distortion technique and a biological motion distortion device were included to assess static and dynamic aspects of body image. Questionnaires assessed cognitive-affective aspects, bodily…

Legenbauer, Tanja; Vocks, Silja; Betz, Sabrina; Puigcerver, Maria Jose Baguena; Benecke, Andrea; Troje, Nikolaus F.; Ruddel, Heinz

2011-01-01

374

Busulfan 12 mg/kg plus melphalan 140 mg/m2 versus melphalan 200 mg/m2 as conditioning regimens for autologous transplantation in newly diagnosed multiple myeloma patients included in the PETHEMA/GEM2000 study  

PubMed Central

Background The aim of this study was to compare the long-term safety and efficacy of oral busulfan 12 mg/kg plus melphalan 140 mg/m2 and melphalan 200 mg/m2 as conditioning regimens for autologous stem cell transplantation in newly diagnosed patients with multiple myeloma in the GEM2000 study. Design and Methods The first 225 patients received oral busulfan 12 mg/kg plus melphalan 140 mg/m2; because of a high frequency of veno-occlusive disease, the protocol was amended and a further 542 patients received melphalan 200 mg/m2. Results Engraftment and hospitalization times were similar in both groups. Oral busulfan 12 mg/kg plus melphalan 140 mg/m2 resulted in higher transplant-related mortality (8.4% versus 3.5%; P=0.002) due to the increased frequency of veno-occlusive disease in this group. Response rates were similar in both arms. With respective median follow-ups of 72 and 47 months, the median progression-free survival was significantly longer with busulfan plus melphalan (41 versus 31 months; P=0.009), although survival was similar to that in the melphalan 200 mg/m2 group. However, access to novel agents as salvage therapy after relapse/progression was significantly lower for patients receiving busulfan plus melphalan (43%) than for those receiving melphalan 200 mg/m2 (58%; P=0.01). Conclusions Conditioning with oral busulfan 12 mg/kg plus melphalan 140 mg/m2 was associated with longer progression-free survival but equivalent survival to that achieved with melphalan 200 mg/m2 but this should be counterbalanced against the higher frequency of veno-occlusive disease-related deaths. This latter fact together with the limited access to novel salvage therapies in patients conditioned with oral busulfan 12 mg/kg plus melphalan 140 mg/m2 may explain the absence of a survival difference. Oral busulfan was used in the present study; use of the intravenous formulation may reduce toxicity and result in greater efficacy, and warrants further investigation in myeloma patients. (Clinicaltrials.gov identifier: NCT00560053).

Lahuerta, Juan Jose; Mateos, Maria Victoria; Martinez-Lopez, Joaquin; Grande, Carlos; de la Rubia, Javier; Rosinol, Laura; Sureda, Anna; Garcia-Larana, Jose; Diaz-Mediavilla, Joaquin; Hernandez-Garcia, Miguel T.; Carrera, Dolores; Besalduch, Joan; de Arriba, Felipe; Oriol, Albert; Escoda, Lourdes; Garcia-Frade, Javier; Rivas-Gonzalez, Concepcion; Alegre, Adrian; Blade, Joan; San Miguel, Jesus F.

2010-01-01

375

[Mental disorders in Lyme disease].  

PubMed

From the early 90-ties there is a growing number of patients suffering from Lyme Disease all over the world, including Poland. Lyme Disease is the disorder connecting physicians of various specialties. The authors reviewed literature on mental disorders in Lyme Disease during different stages and in different types of illness. Mental disorders are part of clinical picture of the acute stage of Lyme Disease, and could also be its sequel. The most commonly found mental disorders are: encephalopathy, other cognitive disorders, mood disorders (depression), anxiety disorders and less often: psychotic disorders and eating disorders (anorexia nervosa). PMID:11852824

Rudnik-Sza?aj, I; Pop?awska, R; Zajkowska, J; Szulc, A; Pancewicz, S A; Gudel, I

2001-11-01

376

Behavior Disorders Program Design.  

ERIC Educational Resources Information Center

Described is a Georgia county school system's program which began in 1972 for behaviorally disordered children (kindergarten through high school). Opening chapters include a rationale for the program, a definition of behavior disorders, and a list of program objectives such as identifying children with behavior disorders and assisting them to…

Seely, Trudy; And Others

377

Anxiety Disorders: Noradrenergic Neurotransmission  

Microsoft Academic Search

The past decade has seen a rapid progression in our knowledge of the neurobiological basis of fear and anxiety. Specific neurochemical and neuropeptide systems have been demonstrated to play important roles in the behaviors associated with fear and anxiety-producing stimuli. Long-term dysregulation of these systems appears to contribute to the development of anxiety disorders, including panic disorder, posttraumatic stress disorder

A. Neumeister; R. J. Daher; D. S. Charney

378

Eating disorders during pregnancy.  

PubMed

Eating disorders during pregnancy, once thought to be rare, occur in a significant number of women. The incidences of the major eating disorders-anorexia nervosa and bulimia nervosa-are increasing because of cultural pressures on the drive for thinness. Because the age range for these major eating disorders overlaps with the age range for reproductive function, it is not unusual for a clinician to encounter a pregnant patient with a major eating disorder. Eating disorders attributable to the pregnant state include pregnancy sickness, pica, and ptyalism. The diagnostic criteria, etiology, nutritional behavioral influences, evolutionary psychological considerations where elucidated, and treatment of these disorders will be presented. Target Audience: Obstetricians and gynecologists, family physicians Learning Objectives: After completing this CME activity, physicians should be better able to review how the major eating disorders impact pregnancy, to diagnose eating disorders during pregnancy using the diagnostic criteria, and to treat eating disorders during pregnancy. PMID:23943041

Cardwell, Michael S

2013-04-01

379

Multiple Chemical Sensitivity: Towards the End of Controversy  

Microsoft Academic Search

There are nine well accepted paradigms of human disease. The tenth may explain the features of multiple chemical sensitivity (MCS) and a group of related illnesses including chronic fatigue syndrome (CFS), fibromyalgia (FM) and posttraumatic stress disorder (PTSD); Gulf War syndrome appears to be a combination of all four. The elevated nitric oxide\\/peroxynitrite vicious cycle paradigm explains most of the

Martin L. Pall

380

Novel immunochemotherapy approaches towards improved targeting of Multiple Myeloma  

Microsoft Academic Search

Multiple myeloma (MM) is a haematological cancer originating from antibody producing plasma cells. Clinical symptoms may include bone pain, infections, renal failure and fatigue due to anemia. MM has an important worldwide clinical impact: it accounts for 10% of all haematological disorders and 1% of all cancers. Despite several achievements in treatment modalities in the past years, MM is still

M. S. van der Veer

2012-01-01

381

Autonomic innervation in multiple system atrophy and pure autonomic failure  

Microsoft Academic Search

BackgroundPure autonomic failure (PAF) and multiple system atrophy (MSA) are both characterised by chronic dysautonomia although presenting different disability and prognosis. Skin autonomic function evaluation by indirect tests has revealed conflicting results in these disorders. Here, the authors report the first direct analysis of skin sympathetic fibres including structure and function in PAF and MSA to ascertain different underlying autonomic

V. Donadio; P. Cortelli; M. Elam; V. Di Stasi; P. Montagna; B. Holmberg; M. P. Giannoccaro; E. Bugiardini; P. Avoni; A. Baruzzi; R. Liguori

2010-01-01

382

Assessing Multiple Outcomes for Women with Co-Occurring Disorders and Trauma in a Multi-Site Trial: A Propensity Score Approach  

Microsoft Academic Search

The current study assesses the ability of two promising propensity scoring methods to reduce selection bias in a set of secondary\\u000a data from the women with co-occurring disorders and violence study (WCDVS), whose purpose was to evaluate the effect of integrated\\u000a treatment for women with mental health, substance use, and trauma issues (N = 2,729). Weighting, the more successful method, is demonstrated

Alan R. Ellis; Joseph P. Morrissey

2009-01-01

383

STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer.  

PubMed

Using sequence profile analysis and sequence-based structure predictions, we define a previously unrecognized, widespread class of P-loop NTPases. The signal transduction ATPases with numerous domains (STAND) class includes the AP-ATPases (animal apoptosis regulators CED4/Apaf-1, plant disease resistance proteins, and bacterial AfsR-like transcription regulators) and NACHT NTPases (e.g. NAIP, TLP1, Het-E-1) that have been studied extensively in the context of apoptosis, pathogen response in animals and plants, and transcriptional regulation in bacteria. We show that, in addition to these well-characterized protein families, the STAND class includes several other groups of (predicted) NTPase domains from diverse signaling and transcription regulatory proteins from bacteria and eukaryotes, and three Archaea-specific families. We identified the STAND domain in several biologically well-characterized proteins that have not been suspected to have NTPase activity, including soluble adenylyl cyclases, nephrocystin 3 (implicated in polycystic kidney disease), and Rolling pebble (a regulator of muscle development); these findings are expected to facilitate elucidation of the functions of these proteins. The STAND class belongs to the additional strand, catalytic E division of P-loop NTPases together with the AAA+ ATPases, RecA/helicase-related ATPases, ABC-ATPases, and VirD4/PilT-like ATPases. The STAND proteins are distinguished from other P-loop NTPases by the presence of unique sequence motifs associated with the N-terminal helix and the core strand-4, as well as a C-terminal helical bundle that is fused to the NTPase domain. This helical module contains a signature GxP motif in the loop between the two distal helices. With the exception of the archaeal families, almost all STAND NTPases are multidomain proteins containing three or more domains. In addition to the NTPase domain, these proteins typically contain DNA-binding or protein-binding domains, superstructure-forming repeats, such as WD40 and TPR, and enzymatic domains involved in signal transduction, including adenylate cyclases and kinases. By analogy to the AAA+ ATPases, it can be predicted that STAND NTPases use the C-terminal helical bundle as a "lever" to transmit the conformational changes brought about by NTP hydrolysis to effector domains. STAND NTPases represent a novel paradigm in signal transduction, whereby adaptor, regulatory switch, scaffolding, and, in some cases, signal-generating moieties are combined into a single polypeptide. The STAND class consists of 14 distinct families, and the evolutionary history of most of these families is riddled with dramatic instances of lineage-specific expansion and apparent horizontal gene transfer. The STAND NTPases are most abundant in developmentally and organizationally complex prokaryotes and eukaryotes. Transfer of genes for STAND NTPases from bacteria to eukaryotes on several occasions might have played a significant role in the evolution of eukaryotic signaling systems. PMID:15381417

Leipe, Detlef D; Koonin, Eugene V; Aravind, L

2004-10-01

384

Traumatic brain injury and delayed sequelae: a review--traumatic brain injury and mild traumatic brain injury (concussion) are precursors to later-onset brain disorders, including early-onset dementia.  

PubMed

Brain injuries are too common. Most people are unaware of the incidence of and horrendous consequences of traumatic brain injury (TBI) and mild traumatic brain injury (MTBI). Research and the advent of sophisticated imaging have led to progression in the understanding of brain pathophysiology following TBI. Seminal evidence from animal and human experiments demonstrate links between TBI and the subsequent onset of premature, psychiatric syndromes and neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Objectives of this summary are, therefore, to instill appreciation regarding the importance of brain injury prevention, diagnosis, and treatment, and to increase awareness regarding the long-term delayed consequences following TBI. PMID:18040539

Kiraly, Michael; Kiraly, Stephen J

2007-11-12

385

Stroke and neurodegenerative disorders. 4. neurodegenerative disorders 1 1 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is\\/are associated  

Microsoft Academic Search

Bryant PR, Geis CC, Moroz A, O’Neill BJ, Bogey RA. Stroke and neurodegenerative disorders. 4. Neurodegenerative disorders. 2004;85(3 Suppl 1):S21–33.This self-directed learning module highlights diagnosis, treatment, and rehabilitation issues in patients with neurodegenerative disorders, including multiple sclerosis (MS), Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). It is part of the study guide on stroke and neurodegenerative disorders in the Self-Directed

Phillip R Bryant; Carolyn C Geis; Alex Moroz; Bryan J O’Neill; Ross A Bogey

2004-01-01

386

Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials  

PubMed Central

Background It is estimated that 22,800 children were living with an Acquired Brain Injury (ABI) (0.6% of children aged under 15 years) in Australia during 2003. Many children after a traumatic brain injury will experience difficulties with attention and concentration; a condition termed secondary Attention Deficit-Hyperactivity Disorder. There is conflicting evidence on whether treatment with stimulant therapy with medications such as methylphenidate or dexamphetamine will improve the attention and behavior of children with this condition. Methods/Design Single patient trials (n-of-1s or SPTs) evaluate the effect of titrated doses of psychostimulants methylphenidate or dexamphetamine compared to placebo on attention and behavior, in children with TBI and secondary ADHD. The aggregation of multiple SPTs will produce a population estimate of the benefit. Forty-two children will be registered into the trial through rehabilitation services at three large children’s hospitals in Australia. Patients will complete up to 3 cycles of treatment. Each cycle is 2 weeks long comprising seven days each of treatment and placebo, with the first two days of each cycle considered a washout period and the data not analysed. The order of treatment and placebo is randomly allocated for each cycle. The Conners’ Parent Rating Scales long forms will be employed to measure change in attention-deficit/hyperactivity and related problems of the child, and the primary outcome measure is the Conners’ Global Index Parent Version. Secondary outcomes include the teacher and child (if aged > 12 years) Conners’ Rating Scales, the Behaviour Rating Inventory of Executive Function among other measures. This study will provide high-level evidence using a novel methodological approach to inform clinicians about the most appropriate treatment for individual children. Through aggregation of individual trials, a population estimate of treatment effect will be provided to guide clinical practice in the treatment of children with secondary ADHD after a traumatic brain injury. Discussion This study employs an innovative methodological approach on the effectiveness of CNS stimulants for secondary ADHD from a brain injury. The findings will both guide clinicians on treatment recommendations, and inform the concept and acceptance of SPTs in paediatric research. Trial registration Australian New Zealand Clinical Trials Registry. ACTRN12609000873224

2013-01-01

387

Gene Transfer Strategies for Correction of Lysosomal Storage Disorders  

Microsoft Academic Search

Lysosomal storage diseases (LSDs) represent a large group of monogenic disorders of metabolism, which affect approximately 1 in 5,000 live births. LSDs result from a single or multiple deficiency of specific lysosomal hydrolases, the enzymes responsible for the luminal catabolization of macromolecular substrates. The consequent accumulation of undigested metabolites in lysosomes leads to polysystemic dysfunction, including progressive neurologic deterioration, mental

Alessandra d’Azzo

2003-01-01

388

Multimodality imaging features of hereditary multiple exostoses.  

PubMed

Hereditary multiple exostoses (HME) or diaphyseal aclasis is an inherited disorder characterised by the formation of multiple osteochondromas, which are cartilage-capped osseous outgrowths, and the development of associated osseous deformities. Individuals with HME may be asymptomatic or develop clinical symptoms, which prompt imaging studies. Different modalities ranging from plain radiographs to cross-sectional and nuclear medicine imaging studies can be helpful in the diagnosis and detection of complications in HME, including chondrosarcomatous transformation. We review the role and imaging features of these different modalities in HME. PMID:24004486

Kok, H K; Fitzgerald, L; Campbell, N; Lyburn, I D; Munk, P L; Buckley, O; Torreggiani, W C

2013-09-04

389

Bone disease in pediatric rheumatologic disorders  

Microsoft Academic Search

Children with rheumatic disorders have multiple risk factors for impaired bone health, including delayed growth and development,\\u000a malnutrition, decreased weight-bearing activity, inflammation, and glucocorticoid therapy. The impact of rheumatic disease\\u000a during childhood may be immediate, resulting in fragility fractures, or delayed, because of suboptimal peak bone mass accrual.\\u000a Recent years have seen increased interest in the effects of pediatric rheumatic

Jon M. Burnham; Mary B. Leonard

2004-01-01

390

Diagnostic Evaluation of Autism Spectrum Disorders  

PubMed Central

Synopsis Research on the identification and evaluation of autism spectrum disorders (ASD) is reviewed and best practices for clinical work are discussed. The latest research on diagnostic tools, and their recommended use, is also reviewed. Recommendations include the use of instruments designed to assess multiple domains of functioning and behavior, the inclusion of parents and caregivers as active partners, and the consideration of developmental factors throughout the diagnostic process.

Huerta, Marisela; Lord, Catherine

2011-01-01

391

Quality of life in patients with multiple sclerosis and urinary disorders: Reliability and validity of Turkish-language version of Incontinence Quality of Life Scale  

Microsoft Academic Search

Incontinence is one of the most frequently encoun- tered problems in multiple sclerosis (MS), and it has a negative effect on the daily lives of patients. Therefore, it is important to investigate this complaint and start appropriate treatment early. The aim of our study was to demonstrate the validity and reliability of the Turkish-language Incontinence Quality of Life Scale (I-QOL)

Sibel Eyigor; Hale Karapolat; Yesim Akkoc; Hilal Yesil; Ozgul Ekmekci

2010-01-01

392

Multiple Sclerosis.  

ERIC Educational Resources Information Center

|This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

Plummer, Nancy; Michael, Nancy, Ed.

393

Cannabinoid Modulation of Neuroinflammatory Disorders  

PubMed Central

In recent years, a growing interest has been dedicated to the study of the endocannabinoid system. The isolation of Cannabis sativa main psychotropic compound, ?9-tetrahydrocannabinol (THC), has led to the discovery of an atypical neurotransmission system that modulates the release of other neurotransmitters and participates in many biological processes, including the cascade of inflammatory responses. In this context, cannabinoids have been studied for their possible therapeutic properties in neuroinflammatory diseases. In this review, historic and biochemical aspects of cannabinoids are discussed, as well as their function as modulators of inflammatory processes and therapeutic perspectives for neurodegenerative disorders, particularly, multiple sclerosis.

Saito, Viviane M; Rezende, Rafael M; Teixeira, Antonio L

2012-01-01

394

Pervasive Developmental Disorders in Girls  

Microsoft Academic Search

Pervasive developmental disorders are a group of conditions sharing as their common features impairment in social reciprocity,\\u000a developmental disturbances affecting communication, and manifestation of restricted and repetitive behaviors. Autism is the\\u000a prototypical pervasive developmental disorder, and others include Asperger's Disorder, Rett's Disorder, Childhood Disintegrative\\u000a Disorder, and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS). Critical to understanding these conditions\\u000a is appreciation of

Kathleen Koenig; Katherine D. Tsatsanis

395

Eosinophilic Disorders  

MedlinePLUS

... Blood Cell Disorders Plasma Cell Disorders Leukemias Lymphomas Myeloproliferative Disorders Spleen Disorders Topics in White Blood Cell ... Trade Names GLEEVEC , a drug used to treat cancer. If these drugs fail, various other drugs may ...

396

Psychotic Disorders  

MedlinePLUS

Psychotic disorders are severe mental disorders that cause abnormal thinking and perceptions. People with psychoses lose touch with ... is not there. Schizophrenia is one type of psychotic disorder. People with bipolar disorder may also have psychotic ...

397

Eating Disorders  

MedlinePLUS

What are Eating Disorders? An eating disorder is an illness that causes serious disturbances to your everyday diet, such as eating extremely ... recruiting participants with eating disorders . Science News About Eating Disorders Biology, Not Just Society, May Increase Risk of ...

398

Bipolar Disorder  

MedlinePLUS

... this brochure to find out more. What is bipolar disorder? Bipolar disorder is a serious brain illness. It ... get better and lead successful lives. Who develops bipolar disorder? Anyone can develop bipolar disorder. It often starts ...

399

Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma  

PubMed Central

In this study, we present a female patient with a constitutional de novo deletion in 7q21.3q31.1 as determined by G-banding and CGH-SNP arrays. She exhibited, among other features, psychomotor retardation, congenital severe bilateral glaucoma, a cleft palate, and heart defect. Microarray assay disclosed a deleted 12.5-Mb region roughly 88 kb downstream the ectrodactyly critical region; thus, the patient's final karyotype was 46,XX.arr 7q21.3q31.1(96,742,140-109,246,085)×1 dn. This girl represents the fourth patient described so far with congenital glaucoma and a deletion encompassing or overlapping the 7q21.3q31.1 region, and confirms the presence of a locus or loci related to such a clinical feature. According to our results, the proneness to ocular defects secondary to 7q intermediate deletions could be caused by co-deletion of TAC1, HBP1, and a small cluster of cytochrome P450 genes (subfamily 3A). This conclusion is supported by their functional roles and expression locations as well as because TAC1 is related to the functional pathway of the MYOC gene whose mutations are linked to glaucoma. Moreover, given that this girl is clinically reminiscent of several phenotypes related to diverse deletions within 7q21q32, our results and observations offer a general overview of the gene content of deletions/phenotypes overlapping 7q21.3q31.1 and confirm that loci distal to DLX genes including the CUX1 gene and potential regulatory elements downstream from DLX5 are unrelated to ectrodactyly.

Martinez-Jacobo, L.; Cordova-Fletes, C.; Ortiz-Lopez, R.; Rivas, F.; Saucedo-Carrasco, C.; Rojas-Martinez, A.

2013-01-01

400

Trousseau's syndrome: multiple definitions and multiple mechanisms  

Microsoft Academic Search

any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syn- drome are partly the consequence of mul- tiple pathophysiologic mechanisms that apparently contribute to the hypercoagu- lability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exag- gerated fluid-phased thrombosis depen- dent on prothrombotic agents

Ajit Varki

2007-01-01

401

Sleep Disorders  

NSDL National Science Digital Library

For something as critical to our well being as good sleep, human beings suffer from an amazing number of sleeping disorders. The following Web sites explore just a few of these disorders, starting with a brief introduction to the normal stages of sleep from the Sleep Disorders Center of Central Texas (1). Next, the University of Waterloo offers a fascinating look at sleep paralysis, which many researchers consider the "likely source of beliefs concerning not only alien abductions, but all manner of beliefs in alternative realities and otherworldly creatures" (2). The third site (3), provided by the National Women's Health Information Center, is an easy-to-read source for information about insomnia. Likewise, the American Sleep Apnea Association (ASAA) offers an in-depth information packet on snoring and sleep apnea, as well as the ASAA newsletter and other resources (4). The next Web site (5 ) comes from the National Institute of Neurological Disorders and Stroke, and offers an introduction to the phenomenon of narcolepsy, including treatment, prognosis, and related research. Restless legs syndrome may not be as immediately familiar as some of the other sleep disorders addressed above, but a visit to the homepage of the Restless Legs Syndrome Foundation (6) should answer any questions about this "creepy-crawly" sensation in the limbs that occurs during sleep or other inactive periods. Of course, you don't have to have a bona fide sleeping disorder to suffer from sleep deprivation. Visitors to the next Web site from Loughborough University's Sleep Research Centre will find detailed information on how sleep deprivation affects brain function (7). Not surprisingly, the news isn't good. Finally, the Sleep Foundation offers How's Your Sleep, an online quiz designed to help users learn more about what may be affecting their sleep (8).

Sohmer, Rachel.

2003-01-01

402

The neuropsychiatry of multiple sclerosis  

Microsoft Academic Search

Multiple sclerosis usually starts between the ages of 20 and 40 and is characterised by multiple demyelinating lesions with a predilection for the optic nerves, cerebellum, brain-stem and spinal cord. The disorder presents with diverse neurological signs, which reflect the presence and distribution of plaques. Multiple sclerosis is predominantly a white matter disease. The course of the illness is variable

Kate Jefferies

2006-01-01

403

Differences in compassion fatigue, symptoms of posttraumatic stress disorder and relationship satisfaction, including sexual desire and functioning, between male and female detectives who investigate sexual offenses against children: a pilot study.  

PubMed

Law enforcement detectives who work with traumatized individuals, especially children who were victims of sexual abuse or assault, are likely to experience job-related emotional distress. The purpose of this study was to examine the relations among compassion fatigue, probable PTSD symptoms, and personal relationship satisfaction, including communication and sexual satisfaction, in a sample of 47 male and female detectives. Responses to the administered questionnaires indicated a relation between compassion fatigue symptoms and probable PTSD symptoms. There also were compelling gender differences. For example, for male detectives, open communication with their spouse or significant other was negatively correlated with burnout, indicating the more open the communication, the lower the reported burnout. However for female detectives there was a negative correlation between open communication with spouse or significant other and compassion satisfaction, suggesting that more open communication was related to lower levels of satisfaction with their ability to be a professional caregiver Furthermore, although stepwise regression analysis indicated that years of service as a detective is independently associated with sexual desire, female detectives evidenced less sexual desire and more difficulty with sexual functioning than did male detectives. Implications of these preliminary findings are discussed and limitations addressed. PMID:21870384

Lane, Eric J; Lating, Jeffrey M; Lowry, Jenny L; Martino, Traci P

2010-01-01

404

[Asperger's syndrome: continuum or spectrum of autistic disorders?].  

PubMed

Pervasive Developmental Disorders (PPD) refers to the group of disorders characterised by delayed or inappropriate development of multiple basic functions including socialisation, communication, behaviour and cognitive functioning. The term,,autistic spectrum disorders" was established as a result of the magnitude of the intensity of symptoms and their proportions observed in all types of pervasive developmental disorders. Asperger's Syndrome (AS) remains the most controversial diagnosis in terms of its place within autism spectrum disorders. AS if often described as an equivalent of High Functioning Autism (HFA) or as a separate spectrum-related disorder with unique diagnostic criteria. Another important issue is the relationship between AS and speech disorders. Although it is relatively easy to draw a line between children with classical autism and speech disorders, the clear cut frontiers between them still remain to be found. The main distinguishing feature is the lack of stereotypic interests and unimpaired social interaction observed in children with speech disorders, such as semantic-pragmatic disorder. PMID:22220491

Bry?ska, Anita

405

Lysosomal disorders.  

PubMed

Although most lysosomal storage disorders present in infancy or early childhood with a progressive condition often associated with dysmorphism, considerable genetic heterogeneity exists resulting in a range of illnesses that can include a dramatic neonatal presentation. Whilst some conditions present with a characteristic neonatal phenotype (e.g. Niemann-Pick disease type C), the remainder present in a nonspecific way often with non-immune hydrops fetalis. Diagnosis can be helped by appropriate radiological studies and, in some patients, evidence of the storage phenomena can be seen in peripheral blood smears or bone marrow aspirates. Unfortunately, for the majority of affected patients no effective, curative, treatment is possible. New developments in therapy including enzyme replacement therapy and substrate deprivation may improve prognosis in some disorders. It is important to establish an accurate diagnosis, as prenatal testing can then be offered in future pregnancies. PMID:12069540

Wraith, J E

2002-02-01

406

An educational rationale for deaf students with multiple disabilities.  

PubMed

Deaf students with with multiple disabilities have a long history of limited opportunity, including limited access to educational opportunities available to their deaf peers. This article places the individual needs of deaf students with multiple disabilities in the context that guides much of deaf education--the importance of language acquisition. That emphasis provides a basis for placement and curriculum options for deaf students with multiple disabilities. The authors review the evolution of placement options, describe assumptions that should guide placement and curriculum decisions, and recommend practices for optimizing these students' education. Descriptions of three service delivery models--multidisciplinary, interdisciplinary, and transdisciplinary--are provided, as well as an overview of the effectiveness of person-centered planning for deaf students with multiple disabilities. Disability-specific resources are highlighted that relate to mental retardation, autism, visual impairments, learning disabilities, attention deficit hyperactivity disorder, emotional disorders, medical issues, and general resources. PMID:14574799

Ewing, Karen M; Jones, Thomas W

2003-01-01

407

Geriatric Disorders  

Microsoft Academic Search

At one time, the psychiatry of old age was believed to be “the darkest area of psychiatry.” The often confounding nature of\\u000a psychiatric disorder in the elderly is illustrated by the large number of terms used over the years to address the diversity\\u000a among geriatric psychiatric patients, including “late paraphrenia,” “vascular depression,” “pseudodementia,” and “masked depression.”\\u000a Many of these labels

Colin A. Depp; Jody Corey-Bloom

408

Reverse Monte Carlo Modeling of Pair Distribution Function Data as a Tool for Separating the Coordination Environments of Multiple Atoms Disordered Over a Single Site  

NASA Astrophysics Data System (ADS)

The local structures of 8 perovskite compounds which contain equal concentrations of 2 transition metal cations disordered over the B-sites have been investigated using reverse Monte Carlo (RMC) modeling of neutron pair distribution function (PDF) data. Such compounds are known to display a number of interesting magnetic and electronic properties which, due to the cation disorder, cannot be correlated with the average long range structure and so remain poorly understood. In compounds with B=Mn/Ru there exists a valence degeneracy between Mn^3+/Ru^5+ and Mn^4+/Ru^4+. We demonstrate that the RMC method can be used as an effective tool to separate out the individual coordination environments of these cations and also to monitor the relative concentrations of the different oxidation states. We find that the valency ratio is governed by the size of the A-site cations. In a different series of Sr2FeMnO6-x perovskites we find that locally the structures are quite different from the average cubic structures, with the local coordination environments more closely resembling those of the brownmillerite structure. In all compounds the octahedra containing Mn^3+ are Jahn-Teller distorted, even if this distortion is not evident in the average structure.

King, Graham; Llobet, Anna; Ricciardo, Rebecca; Soliz, Jennifer; Woodward, Patrick; Ramezanipour, Farshid; Greedan, John

2012-02-01

409

Combining Information from Multiple Sources for the Diagnosis of Autism Spectrum Disorders for Toddlers and Young Preschoolers from 12 to 47 Months of Age  

PubMed Central

Background Purpose of this study was to systematically examine combined use of the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) for children under age 4 using newly developed and revised diagnostic algorithms. Methods Single and combined use of the ADI-R and ADOS algorithms were compared to clinical best estimate diagnoses for 435 children with Autism Spectrum Disorders (ASD), 113 children with non-spectrum disorders, and 47 children with typical development from 12 to 47 months of age. Sequential strategies to reach a diagnostic decision by prioritizing administrations of instruments were also evaluated. Results Well-balanced sensitivities and specificities above 80% were obtained for ASD diagnoses using both instruments. Specificities significantly improved when both instruments were used compared to one. Scores that can be used to systematically prioritize administrations of instruments were identified. Conclusions The ADI-R and ADOS make independent, additive contributions to more accurate diagnostic decisions for clinicians evaluating toddlers and young preschoolers with ASD. Sequential assessment strategies using the scores identified may be appropriate for some children.

Kim, So Hyun; Lord, Catherine

2011-01-01

410

[Dysmorphophobia (body dysmorphic disorder)].  

PubMed

This article reviews the historical and terminological origins of dysmorphophobia from Herodotus to today. It explains the differences pointed out by many authors, including the DSM-III-R, between body dismorphic disorder and delusional disorder somatic type, which are referred to as monosymptomatic hypochondriacal psychoses in Europe. Epidemiological data, clinical characteristics and outcome are discussed. Explicative theories and neurobiological, developmental and analytical aspects of body image are presented. The association between body dismorphic disorder and other disorders is analyzed, and treatment possibilities are discussed. The authors suggest that body dismorphic disorder be classified with obsessive compulsive disorder, whatever the intensity of symptomatology, rather than with somatoform or delusional disorder, and treated with serotonin uptake inhibitors or neureptics that have been proven to be effective for the treatment of this disorder, such as pimozide. PMID:1423148

Filteau, M J; Pourcher, E; Baruch, P; Bouchard, R H; Vincent, P

1992-09-01

411

Psychopharmacology of anxiety disorders  

PubMed Central

Exposure of the general population to a 1:4 lifetime risk of disabling anxiety has inspired generations of fundamental and clinical psychopharmacologists, from the era of the earliest benzodiazepines (BZ) to that of the selective serotonin reuptake inhibitors (SSRIs) and related compounds, eg, the serotonin and norepinephrine reuptake inhibitors (SNRIs). This comprehensive practical review summarizes current therapeutic research across the spectrum of individual disorders: generalized anxiety disorder (GAD), panic disorder (PD) and agoraphobia (social anxiety disorder), compulsive disorder (OCD), phobic disorder (including social phobia), and posttraumatic stress disorder (PTSD). Specific diagnosis is a precondition to successful therapy: despite substantial overlap, each disorder responds preferentially to specific pharmacotherapy. Comorbidity with depression is common; hence the success of the SSRIs, which were originally designed to treat depression. Assessment (multidomain measures versus individual end points) remains problematic, as-frequently-do efficacy and tolerability The ideal anxiolytic remains the Holy Grail of worldwide psychopharmacologic research.

Cassano, Giovanni B.; Rossi, Nicolo Baldini; Pini, Stefano

2002-01-01

412

Noonan syndrome and related disorders: genetics and pathogenesis.  

PubMed

Noonan syndrome is a pleiomorphic autosomal dominant disorder with short stature, facial dysmorphia, webbed neck, and heart defects. In the past decade, progress has been made in elucidating the pathogenesis of this disorder using a positional cloning approach. Noonan syndrome is now known to be a genetically heterogeneous disorder with nearly one half of cases caused by gain-of-function mutations in PTPN11, the gene encoding the protein tyrosine phosphatase SHP-2. Similar germ line mutations cause two related genetic disorders, Noonan-like disorder with multiple giant cell lesion syndrome and LEOPARD syndrome, and somatic PTPN11 mutations can underlie certain pediatric hematopoietic malignancies, including juvenile myelomonocytic, acute lymphoblastic, and acute myelogenous leukemias. A mouse model of PTPN11-related Noonan syndrome was recently generated, providing a reagent for studying disease pathogenesis in greater depth as well as experimenting with novel therapeutic strategies. PMID:16124853

Tartaglia, Marco; Gelb, Bruce D

2005-01-01

413

Immune Disorders and Its Correlation with Gut Microbiome  

PubMed Central

Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies support the association of hygiene hypothesis in allergic immune disorders that a lack of early childhood exposure to diverse microorganism increases susceptibility to allergic diseases. Among the symbiotic microorganisms (e.g. gut flora or probiotics), probiotics confer health benefits through multiple action mechanisms including modification of immune response in gut associated lymphoid tissue (GALT). Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse immune disorders, this effect is strain specific and needs to apply specific probiotics for specific allergic diseases. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders.

Hwang, Ji-Sun; Im, Chang-Rok

2012-01-01

414

The relationship of obsessive-compulsive disorder to putative spectrum disorders: results from an Indian study  

Microsoft Academic Search

The relationship between obsessive-compulsive disorder (OCD) and putative obsessive-compulsive (OC) spectrum disorders is unclear. This study investigates the prevalence of putative OC spectrum disorders in OCD subjects in a controlled clinical design. The putative OC spectrum disorders studied included somatoform disorders (body dysmorphic disorder [BDD] and hypochondriasis), eating disorders, tic disorders (e.g., Tourette’s syndrome [TS]), and impulse control disorders (e.g.,

T. S Jaisoorya; Y. C. Janardhan Reddy; S Srinath

2003-01-01

415

Including Your Child  

NSDL National Science Digital Library

This publication, recently released by the US Department of Education, deal with special needs children and their parents. Including Your Child is a booklet for parents that deals with the first eight years of life for children with special needs. Its eight brief sections discuss the importance of the family, help and support systems, expectations, how to plan to meet expectations, inclusion, and outreach. It also contains a developmental progress chart and several sections of resource information.

416

Diagnostic issues in bipolar disorder  

Microsoft Academic Search

Bipolar disorder is a highly recurrent and chronic psychiatric condition that shortens life expectancy, causes functional impairment and disruption to social, work and family life. Several forms of bipolar disorder are recognised, including both bipolar I and bipolar II disorder. Bipolar I is characterised by recurrent episodes of depression and mania whereas bipolar II disorder is characterised by recurrent depression

Jules Angst; Alex Gamma; Franco Benazzi; Vladeta Ajdacic; Dominique Eich; Wulf Rössler

2003-01-01

417

Movement Disorders in Dental Practice  

Microsoft Academic Search

Movement disorders are collectively attributed to primary degeneration or dysfunction of the basal ganglia, an area of the brain that includes caudate nucleus, putamen, globus pallidus, subthalamic nucleus and substantia nigra, with extensive afferent and efferent connections. Movement disorders are divided into two general groups: hypokinetic and hyperkinetic disorders. The prototype hypokinetic movement disorder is Parkinson’s disease (PD), the most

Nina M. Browner; Steven Frucht

418

Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and ?-opioid receptor M1 variation  

PubMed Central

This study examined the interplay between the influence of peers who promote alcohol use and ?-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the “traitlike” components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17–23 years) to adulthood (29–40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways.

CHASSIN, LAURIE; LEE, MATTHEW R.; CHO, YOUNG IL; WANG, FRANCES L.; AGRAWAL, ARPANA; SHER, KENNETH J.; LYNSKEY, MICHAEL T.

2013-01-01

419

All About Multiplication  

NSDL National Science Digital Library

This unit consists of four lessons in which students explore several meanings and representations of multiplication, including number lines, sets, arrays, and balance beams. They also learn about the commutative property of multiplication, the results of multiplying by 1 and by 0, and the inverse property of multiplication. Students write story problems and create pictographs. The unit includes activity sheets, assessment ideas, links to related applets, reflective questions for students and teachers, extensions and a bibliography of children's literature with a multiplication focus.

Burton, Grace M.

2000-01-01

420

Diabetes and psychiatric disorders  

PubMed Central

Interface of diabetes and psychiatry has fascinated both endocrinologists and mental health professionals for years. Diabetes and psychiatric disorders share a bidirectional association -- both influencing each other in multiple ways. The current article addresses different aspects of this interface. The interaction of diabetes and psychiatric disorders has been discussed with regard to aetio-pathogenesis, clinical presentation, and management. In spite of a multifaceted interaction between the two the issue remains largely unstudied in India.

Balhara, Yatan Pal Singh

2011-01-01

421

[Multiple autoimmune syndromes].  

PubMed

The possibility of three or more autoimmune diseases occurring in the same patient cannot be fortuitous and suggests a pathogenic relationship between each of them. In the light of 4 personal cases, the authors have recorded 87 reports of such associations in the literature, an analysis of which leads them to propose a classification of three types of multiple autoimmune syndrome. The grouping of these syndromes under a single heading should make the research and analysis of these morbid associations easier. Moreover, the classification adopted by the authors allows a more precise definition of patients with at least two autoimmune diseases and so helps to recognize the onset of a third autoimmune disease at a later date. Multiple autoimmune syndromes can be classified in 3 groups according to the prevalence of their associations one with another. Type I comprises myasthenia, thymoma, polymyositis and giant cell myocarditis, this association having a single pathogenic mechanism. Type II includes the Sjögren's syndrome, rhumatoid arthritis, primary biliary cirrhosis, scleroderma and autoimmune thyroid disorders. Type III groups together 10 autoimmune diseases (autoimmune thyroid disease, myasthenia and/or thymoma, Sjögren's syndrome, pernicious anaemia, idiopathic thrombocytopaenic purpura, Addison's disease, insulin-dependent diabetes, vitiligo, autoimmune haemolytic anaemia, systemic lupus erythematosus) for which a genetic predisposition (phenotype HLA B8 and/or DR3 or DR5) seems to be an important factor. PMID:3059902

Humbert, P; Dupond, J L

1988-01-01

422

Treatment of comorbidity in conduct disorder with attention-deficit hyperactivity disorder (ADHD).  

PubMed

Conduct disorder (CD) is one of the most common psychiatric disorders in childhood and adolescence. It is characterized by a variety of chronic antisocial behaviors, a repetitive and persistent pattern of behavior that violates the basic rights of others, major age-appropriate societal norms, or both. Aggressive behavior, lying, stealing, fire-setting, and running away from home and school are the most frequent manifestations of CD and are often accompanied by hyperactivity, impulsive behavior, explosiveness, cognitive and learning problems, and poor social skills. The rate of comorbidity is high, with attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) being the most common; comorbid anxiety and depressive disorders are also seen, especially in adolescents. The diagnostic process should include the use of structured interviews, and scores from reliable and valid rating scales that cover all psychiatric disorders must be considered in the differential diagnosis, because CD alone is an extreme rarity and multiple disorders are almost always the rule rather than exception. Treatment should include parenting skills training combined with training of the child to improve his or her relationships with peers, academic performance, and compliance with legitimate demands of authority figures. The appropriate use of medications and integration of patient/parent education and support, as well as individual, group, family, residential, and inpatient treatment may be beneficial for patients with CD and ADHD. The article describes a number of psychopharmacological agents that are used in patients with CD with ADHD and other comorbid disorders. Drugs that may be useful include psychostimulants; atomoxetine (Strattera); antidepressants (imipramine [Tofranil], desipramine [Norpramin]); Selective Serotonin Reuptake Inhibitors (SSRIs); atypical antipsychotics such as risperidone (Risperdal); or mood regulators including lithium (Eskalith). PMID:16222912

Turgay, Atilla

2005-01-01

423

Multiple Sclerosis  

MedlinePLUS

MENU Return to Web version Multiple Sclerosis Overview What is multiple sclerosis (MS)? Multiple sclerosis is an autoimmune disease that affects the nervous system. Normally, antibodies produced by ...

424

Adult onset tic disorders  

PubMed Central

BACKGROUND—Tic disorders presenting during adulthood have infrequently been described in the medical literature. Most reports depict adult onset secondary tic disorders caused by trauma, encephalitis, and other acquired conditions. Only rare reports describe idiopathic adult onset tic disorders, and most of these cases represent recurrent childhood tic disorders.?OBJECTIVE—To describe a large series of patients with tic disorders presenting during adulthood, to compare clinical characteristics between groups of patients, and to call attention to this potentially disabling and underrecognised neurological disorder.?METHODS—Using a computerised database, all patients with tic disorders who presented between 1988 and 1998 to the movement disorders clinic at Columbia-Presbyterian Medical Center after the age of 21 were identified. Patients' charts were retrospectively reviewed for demographic information, age of onset of tics, tic phenomenology, distribution, the presence of premonitory sensory symptoms and tic suppressibility, family history, and associated psychiatric features. These patients' videotapes were reviewed for diagnostic confirmation and information was obtained about disability, course, and response to treatment in a structured follow up interview.?RESULTS—Of 411 patients with tic disorders in the database, 22 patients presented for the first time with tic disorders after the age of 21. In nine patients, detailed questioning disclosed a history of previous childhood transient tic disorder, but in 13patients, the adult onset tic disorder was new. Among the new onset cases, six patients developed tics in relation to an external trigger, and could be considered to have secondary tic disorders. The remaining patients had idiopathic tic disorders. Comparing adult patients with recurrent childhood tics and those with new onset adult tics, the appearance of the tic disorder, the course and prognosis, the family history of tic disorder, and the prevalence of obsessive-compulsive disorder were found to be similar. Adults with new onset tics were more likely to have a symptomatic or secondary tic disorder, which in this series was caused by infection, trauma, cocaine use, and neuroleptic exposure.?CONCLUSIONS—Adult onset tic disorders represent an underrecognised condition that is more common than generally appreciated or reported. The clinical characteristics of adults newly presenting to a movement disorder clinic with tic disorders are reviewed, analysed, and discussed in detail. Clinical evidence supports the concept that tic disorders in adults are part of a range that includes childhood onset tic disorders and Tourette's syndrome.??

Chouinard, S.; Ford, B.

2000-01-01

425

Mitochondrial Disorders with Significant Ophthalmic Manifestations  

PubMed Central

Mitochondrial diseases are a clinically hetyerogenous group of disorders. They can be caused by mutations of nuclear or mitochondrial DNA (mtDNA). Some affect a single organ, but many involve multiple organ systems and often present with prominent neurologic and myopathic features. The eye is frequently affected, along with muscles and brain, but multisystem disease is common. Ophthalmic manifestations include cataract, retinopathy, optic atrophy, cortical visual loss, ptosis and ophthalmoplegia. Kearns-Sayre Syndrome (KSS), Mitochondrial Encephalopathy, Lactic Acidosis Stroke (MELAS), Myoclonic Epilepsy and Ragged Red Fiber myopathy (MERRF) and Lebers Hereditary Optic Neuropathy (LHON) are well known clinical entities that are secondary to mtDNA abnormalities, which has ophthalmic manifestations. Mitochondrial Dysfunction should be considered in the differential diagnosis of progressive multisystem disorder and specifically if there is associated neuro-ophthalmic manifestations, which may be the presenting symptom of these disorders.

Al-Enezi, Mona; Al-Saleh, Hanan; Nasser, Murad

2008-01-01

426

Convergent Paradigms for Visual Neuroscience and Dissociative Identity Disorder  

Microsoft Academic Search

Although dissociative identity disorder, a condition in which multiple individuals appear to inhabit a single body, is a recognized psychiatric disorder, patients may yet encounter health professionals who declare that they simply “do not believe in multiple personalities.” This article explores the proposal that resistance to the disorder represents a failure to apply an appropriate paradigm from which the disorder

Mark L. Manning; Rana L. Manning

2009-01-01

427

Hyperhomocysteinaemia and multiple aneurysms.  

PubMed Central

Homozygous homocystinuria, the most common genetic disorder of transulphuration, is associated with elevated plasma concentrations of homocystine, homocysteine, multiple clinical abnormalities and life-threatening thromboembolism. Several instances of vascular aneurysms have also been documented. More recently, an association between premature occlusive vascular disease and the heterozygous state has been proposed. We now report an unusual case in whom multiple aneurysms were associated with heterozygous homocystinuria. Images Figure 1 Figure 2

Colwell, N.; Clarke, R.; Robinson, K.; Keane, F.; O'Briain, S.; Graham, I.

1991-01-01

428

Autism Spectrum Disorders (Pervasive Developmental Disorders)  

MedlinePLUS

... or learning disorders, the comprehensive evaluation may include brain imaging and gene tests, along with in-depth memory, problem-solving, and language testing. Children with any delayed development should also get a hearing test and be ...

429

Multiple Reflections  

NSDL National Science Digital Library

This activity on multiple reflections is produced by the International Society for Optical Engineering, the Optical Society of America, and the Association of Universities for Research in Astronomy. Two plane rectangular mirrors, that meet on one edge, produce various reflection patterns. Students learn the relationship between the number of images produced and the orientation of the two mirrors. The site lists all necessary tools and materials and includes numerous helpful photographs and diagrams.

2009-01-13

430

Bipolar Disorder  

MedlinePLUS

... be tied to their monthly menstrual cycle . How Is Bipolar Disorder Diagnosed? Most people with bipolar disorder can be helped — but a psychiatrist or psychologist must first diagnose the disorder. Sadly, many people with the condition are ...

431

Personality disorders  

MedlinePLUS

Personality disorders are a group of mental health conditions in which a person has a long-term pattern ... Causes of personality disorders are unknown. Genetic and ... a role. Mental health professionals categorize these disorders ...

432

Swallowing Disorders  

MedlinePLUS

NINDS Swallowing Disorders Information Page Synonym(s): Dysphagia Table of Contents (click to jump to sections) What are Swallowing Disorders? Is ... is being done? Clinical Trials Organizations What are Swallowing Disorders? Having trouble swallowing (dysphagia) is a symptom that ...

433

Eating Disorders  

MedlinePLUS

What are eating disorders? An eating disorder is an illness that causes serious disturbances to your everyday diet, such as eating extremely ... population. 5 What are the different types of eating disorders? Anorexia nervosa Anorexia nervosa is characterized by: Extreme ...

434

Eating Disorders  

MedlinePLUS

... normal weight or can be overweight. Continue Binge Eating Disorder This eating disorder is similar to anorexia and ... and celebrations involving food Back Continue What Causes Eating Disorders? No one is really sure what causes eating ...

435

Mathematics disorder  

MedlinePLUS

Mathematics disorder is a condition in which a child's math ability is far below normal for their age, ... Children who have mathematics disorder may have trouble performing ... adding. Mathematical disorder may appear with: Developmental ...

436

Parental psychiatric disorders and autism spectrum disorders.  

PubMed

The present population-based, case-control study examines associations between specific parental psychiatric disorders and autism spectrum disorders (ASD) including childhood autism, Asperger's syndrome and pervasive developmental disorder (PDD-NOS). The cohort includes 4713 children born between 1987 and 2005 with diagnoses of childhood autism, Asperger's syndrome or PDD-NOS. Cases were ascertained from the Finnish Hospital Discharge Register, and each was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Controls were selected from the Finnish Medical Birth Register. Parents were identified through the Finnish Medical Birth Register and Finnish Central Population Register. Parental psychiatric diagnoses from inpatient care were collected from the Finnish Hospital Discharge Register. Conditional logistic regression models were used to assess whether parents' psychiatric disorders predicted ASD after controlling for parents' age, smoking during pregnancy and weight for gestational age. In summary, parental schizophrenia spectrum disorders and affective disorders were associated with the risk of ASD regardless of the subgroup. PDD-NOS was associated with all parental psychiatric disorders investigated. Further studies are needed to replicate these findings. These results may facilitate the investigation of shared genetic and familial factors between ASD and other psychiatric disorders. PMID:23391634

Jokiranta, Elina; Brown, Alan S; Heinimaa, Markus; Cheslack-Postava, Keely; Suominen, Auli; Sourander, Andre

2013-02-04

437

Report of Fertility in a Woman with a Predominantly 46,XY Karyotype in a Family with Multiple Disorders of Sexual Development  

PubMed Central

Context: We report herein a remarkable family in which the mother of a woman with 46,XY complete gonadal dysgenesis was found to have a 46,XY karyotype in peripheral lymphocytes, mosaicism in cultured skin fibroblasts (80% 46,XY and 20% 45,X) and a predominantly 46,XY karyotype in the ovary (93% 46,XY and 6% 45,X). Patients: A 46,XY mother who developed as a normal woman underwent spontaneous puberty, reached menarche, menstruated regularly, experienced two unassisted pregnancies, and gave birth to a 46,XY daughter with complete gonadal dysgenesis. Results: Evaluation of the Y chromosome in the daughter and both parents revealed that the daughter inherited her Y chromosome from her father. Molecular analysis of the genes SOX9, SF1, DMRT1, DMRT3, TSPYL, BPESC1, DHH, WNT4, SRY, and DAX1 revealed normal male coding sequences in both the mother and daughter. An extensive family pedigree across four generations revealed multiple other family members with ambiguous genitalia and infertility in both phenotypic males and females, and the mode of inheritance of the phenotype was strongly suggestive of X-linkage. Conclusions: The range of phenotypes observed in this unique family suggests that there may be transmission of a mutation in a novel sex-determining gene or in a gene that predisposes to chromosomal mosaicism.

Dumic, Miroslav; Lin-Su, Karen; Leibel, Natasha I.; Ciglar, Srecko; Vinci, Giovanna; Lasan, Ruzica; Nimkarn, Saroj; Wilson, Jean D.; McElreavey, Ken; New, Maria I.

2008-01-01

438

Conditional disorder in chaperone action  

PubMed Central

Protein disorder remains an intrinsically fuzzy concept. Its role in protein function is difficult to conceptualize and its experimental study is challenging. Although a wide variety of roles for protein disorder have been proposed, establishing that disorder is functionally important, particularly in vivo, is not a trivial task. Several molecular chaperones have now been identified as conditionally disordered proteins; fully folded and chaperone-inactive under non-stress conditions, they adopt a partially disordered conformation upon exposure to distinct stress-conditions. This disorder appears to be vital for their ability to bind multiple aggregation-sensitive client proteins and to protect cells against the stressors. The study of these conditionally disordered chaperones should prove useful in understanding the functional role for protein disorder in molecular recognition.

Bardwell, James C. A.; Jakob, Ursula

2012-01-01

439

Medical Burden in Late-Life Bipolar and Major Depressive Disorders  

PubMed Central

Background Elderly patients with bipolar disorder have been found to have higher mortality than those with major depressive disorder. The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder. Methods Fifty-four patients with bipolar I or II disorder who were 60 years of age and older were equated 1-to-2 to 108 patients with nonpsychotic, major depressive disorder according to age, sex, race, and lifetime duration of mood disorder illness. Variables examined included the following: Cumulative Illness Rating Scale for Geriatrics (CIRS-G) total scores, body mass index (BMI), and CIRS-G subscale scores. Results Compared with patients with major depressive disorder, patients with bipolar disorder had similar levels of general medical comorbidity on the CIRS-G total score and number of systems affected but higher BMI. After controlling for multiple comparisons, the endocrine/metabolic and respiratory subscale scores on the CIRS-G were higher for patients with bipolar disorder. Conclusion Although overall medical burden appears comparable in elderly patients with bipolar and those with major depressive disorder, patients with bipolar disorder have higher BMI and greater burden of endocrine/metabolic and respiratory disease.

Gildengers, Ariel G.; Whyte, Ellen M.; Drayer, Rebecca A.; Soreca, Isabella; Fagiolini, Andrea; Kilbourne, Amy M.; Houck, Patricia R.; Reynolds, Charles F.; Frank, Ellen; Kupfer, David J.; Mulsant, Benoit H.

2009-01-01

440

Multiple Myeloma and Diabetes  

PubMed Central

Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. It is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. The prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. The treatment of multiple myeloma and diabetes mellitus is multifaceted. The coexistence of the two conditions in a patient forms a major challenge for physicians.

Issa, Zeinab A.; Zantout, Mira S.; Azar, Sami T.

2011-01-01

441

SOMATIC SYMPTOMS IN MULTIPLE SCLEROSIS AND MPD  

Microsoft Academic Search

In this report 50 subjects with multiple sclerosis are compared to 50 subjects with multiple personality disorder. The multiple sclerosis patients endorsed an average (1 3.0 somatic symptoms on structuredinterview, the multiple personality subjects an average of 14.5. The somatic symptoms characteristic of neurological illness were trouble walking, paralysis, and muscle weakness. Those characteristic of psychiatric illness were genitourinary and

Colin A. Ross; Geri Anderson; Anthony Auty; Judy Todd; Cohn A. Ross

442

Oppositional defiant and conduct disorder behaviors in boys with autism spectrum disorder with and without attention-deficit hyperactivity disorder versus several comparison samples.  

PubMed

We compared disruptive behaviors in boys with either autism spectrum disorder (ASD) plus ADHD (n = 74), chronic multiple tic disorder plus ADHD (n = 47), ADHD Only (n = 59), or ASD Only (n = 107). Children were evaluated with parent and teacher versions of the Child Symptom Inventory-4 including parent- (n = 168) and teacher-rated (n = 173) community controls. Parents rated children in the three ADHD groups comparably for each symptom of oppositional defiant disorder (ODD) and conduct disorder. Teacher ratings indicated that the ASD + ADHD group evidenced a unique pattern of ODD symptom severity, differentiating them from the other ADHD groups, and from the ASD Only group. The clinical features of ASD appear to influence co-morbid, DSM-IV-defined ODD, with implications for nosology. PMID:19288296

Guttmann-Steinmetz, Sarit; Gadow, Kenneth D; Devincent, Carla J

2009-03-16

443

Anxiety disorders: a comprehensive review of pharmacotherapies  

Microsoft Academic Search

This article reviews the evidence from random- ized, placebo-controlled trials and meta-analyses of pharmacological treatments of the following anxiety disorders: generalized anxiety disorder, panic dis- order, social anxiety disorder, and post-traumatic stress disorder. There is evidence from multiple ran- domized, placebo-controlled trials to support the use of selective serotonin reuptake inhibitors as first-line pharmacotherapy in these disorders, and a number

Ellen J. Hoffman; Sanjay J. Mathew

2008-01-01

444

Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4  

PubMed Central

Although the physiological function of the prion protein remains unknown, in vitro experiments suggest that the protein may bind copper (II) ions and play a role in copper transport or homoeostasis in vivo. The unstructured N-terminal region of the prion protein has been shown to bind up to six copper (II) ions, with each of these ions co-ordinated by a single histidine imidazole and nearby backbone amide nitrogen atoms. Individually, these sites have micromolar affinities, which is weaker than would be expected of a true cuproprotein. In the present study, we show that with subsaturating levels of copper, different forms of co-ordination will occur, which have higher affinity. We have investigated the copper-binding properties of two peptides representing the known copper-binding regions of the prion protein: residues 57–91, which contains four tandem repeats of the octapeptide GGGWGQPH, and residues 91–115. Using equilibrium dialysis and spectroscopic methods, we unambiguously demonstrate that the mode of copper co-ordination in both of these peptides depends on the number of copper ions bound and that, at low copper occupancy, copper ions are co-ordinated with sub-micromolar affinity by multiple histidine imidazole groups. At pH 7.4, three different modes of copper co-ordination are accessible within the octapeptide repeats and two within the peptide comprising residues 91–115. The highest affinity copper (II)-binding modes cause self-association of both peptides, suggesting a role for copper (II) in controlling prion protein self-association in vivo.

Wells, Mark A.; Jelinska, Clare; Hosszu, Laszlo L. P.; Craven, C. Jeremy; Clarke, Anthony R.; Collinge, John; Waltho, Jonathan P.; Jackson, Graham S.

2006-01-01

445

Should Relational Aggression Be Included in DSM-V?  

ERIC Educational Resources Information Center

|The study examines whether relational aggression should be included in DSM-V disruptive behavior disorders. The results conclude that some additional information is gathered from assessing relational aggression but not enough to be included in DSM-V.|

Keenan, Kate; Coyne, Claire; Lahey, Benjamin B.

2008-01-01

446

Attention Deficit Hyperactivity Disorder (ADHD)  

MedlinePLUS

Attention deficit/hyperactivity disorder (ADHD) is one of the most common mental disorders in children and adolescents. ... year. Symptoms include difficulty staying focused and paying attention, difficulty controlling behavior, and very high levels of ...

447

Achalasia and Esophageal Motility Disorders  

MedlinePLUS

... tests to evaluate for achalasia and other esophageal motility disorders is manometry. This test is performed on an outpatient basis. A small ... coordination of contractions of the esophageal muscles. Some motility disorders, including ... TREATMENTS ARE AVAILABLE FOR ACHALASIA? Endoscopic Treatment ...

448

Quality of life in multiple sclerosis patients with urinary disorders: reliability and validity of the Turkish version of King’s Health Questionnaire  

Microsoft Academic Search

MS patients frequently present with urinary system symptoms, which have a negative effect on the quality life. The aim of\\u000a our study was to demonstrate the validity and reliability of the Turkish King’s Health Questionnaire (KHQ) in MS patients.\\u000a The study included 37 patients. For analysis of test–retest reliability, the Turkish version of the KHQ developed and the\\u000a “translation-back translation”

Ye?im Akkoc; Hale Karapolat; Sibel Eyigor; Hilal Yesil; Nur Yüceyar

2011-01-01

449

Sleep disorders in patients with traumatic brain injury: a review.  

PubMed

Traumatic brain injury (TBI) is a global problem and causes long-term disability in millions of individuals. This is a major problem for both military- and civilian-related populations. The prevalence of sleep disorders in individuals with TBI is very high, yet mostly unrecognized. Approximately 46% of all chronic TBI patients have sleep disorders, which require nocturnal polysomnography and the Multiple Sleep Latency Test for diagnosis. These disorders include sleep apnoea (23% of all TBI patients), post-traumatic hypersomnia (11%), narcolepsy (6%) and periodic limb movements (7%). Over half of all TBI patients will have insomnia complaints, most often with less severe injury and after personal assault, and half of these may be related to a circadian rhythm disorder. Hypothalamic injury with decreased levels of wake-promoting neurotransmitters such as hypocretin (orexin) and histamine may be involved in the pathophysiology of excessive sleepiness associated with TBI. These sleep disorders result in additional neurocognitive deficits and functional impairment, which might be attributed to the original brain injury itself and thus be left without specific treatment. Most standard treatment regimens of sleep disorders appear to be effective in these patients, including continuous positive airway pressure for sleep apnoea, pramipexole for periodic limb movements and cognitive behavioural therapy for insomnia. The role of wake-promoting agents and CNS stimulants for TBI-associated narcolepsy, post-traumatic hypersomnia and excessive daytime sleepiness requires further study with larger numbers of patients to determine effectiveness and benefit in this population. Future research with multiple collaborating centres should attempt to delineate the pathophysiology of TBI-associated sleep disorders, including CNS-derived hypersomnia and circadian rhythm disturbances, and determine definitive, effective treatment for associated sleep disorders. PMID:21062105

Castriotta, Richard J; Murthy, Jayasimha N

2011-03-01

450

Somatosensory processing in neurodevelopmental disorders  

Microsoft Academic Search

The purpose of this article is to review the role of somatosensory perception in typical development, its aberration in a\\u000a range of neurodevelopmental disorders, and the potential relations between tactile processing abnormalities and central features\\u000a of each disorder such as motor, communication, and social development. Neurodevelopmental disorders that represent a range\\u000a of symptoms and etiologies, and for which multiple peer-reviewed

Carissa J. Cascio

2010-01-01

451

Autistic disorder and viral infections  

Microsoft Academic Search

Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide range of behaviors. Although the etiology\\u000a of autism is unknown, data suggest that autism results from multiple etiologies with both genetic and environmental contributions,\\u000a which may explain the spectrum of behaviors seen in this disorder. One proposed etiology for autism is viral infection very\\u000a early in development. The

Jane E. Libbey; Thayne L. Sweeten; William M. McMahon; Robert S. Fujinami

2005-01-01

452

Successful Autologous Hematopoietic Stem Cell Transplantations for Severe Multiple Sclerosis with Fludarabine and Cyclophosphamide Conditioning  

Microsoft Academic Search

Conditioning regimens for hematopoietic stem cell transplantations (HSCT) for autoimmune disease have generally been derived from intensive myeloablative protocols used for transplantation for hematological disorders. These include BEAM (comprising BCNU [1,3-bis(2-chloroethyl)1-nitrosourea], cytosine arabinoside, etoposide, and melphalan) with antithymocyte globulin [1] and several total body irradiation?based regimens [2,3]. However, as multiple sclerosis (MS) is chiefly an immune-mediated disorder, it is believed

Su Ming Yvonne Loh; Pavanni Ratnagopal; Huat Chye Patrick Tan; Yeow Tee Goh; Boon Chai Mickey Koh; Liang Piu Koh; Yeh Ching Linn; William Ying Khee Hwang