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Sample records for docket nos 50-390

  1. Safety Evaluation Report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 12

    SciTech Connect

    Tam, P.S.

    1993-10-01

    Supplement No. 12 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation of (1) additional information submitted by the applicant since Supplement No. 11 was issued, and (2) matters that the staff had under review when Supplement No. 11 was issued.

  2. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 14

    SciTech Connect

    Tam, P.S.

    1994-12-01

    Supplement No. 14 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation with additional information submitted by the applicant since Supplement No. 13 was issued, and matters that the staff had under review when Supplement No. 13 was issued.

  3. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391): Supplement No. 19

    SciTech Connect

    1995-11-01

    Supplement No. 19 to the Safety Evaluation Report for the application filed by the Tennessee Valley Authority for license to operate Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, located in Rhea County Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation with (1) additional information submitted by the applicant since Supplement No. 18 was issued, and (2) matters that the staff had under review when Supplement No. 18 was issued.

  4. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 15

    SciTech Connect

    Tam, P.S.

    1995-06-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), and Supplement No. 14 (December 1994) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the outstanding and confirmatory items, and proposed license conditions identified in the SER.

  5. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 17

    SciTech Connect

    Tam, P.S.

    1995-10-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April.1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), and Supplement No. 16 (September 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50--390 and 50--391). The facility is located in Rhea county, Tennessee, near the Watts Bar Dam on the Tennessee River. In this supplement, NRC examines the significant problems of construction quality and quality assurance effectiveness that led TVA to withdraw its certification in 1985 that Watts Bar Unit I was ready to load fuel. Also discussed are the extensive corrective actions performed by TVA according to its nuclear performance plans and other supplemental programs, and NRC`s extensive oversight to determine whether the Watts Bar Unit 1 construction quality and TVA`s operational readiness and quality assurance effectiveness are adequate for a low-power operating license to be issued. SSER 17 does not address Watts Bar Unit 2, except for the systems which are necessary to support Unit 1 operation.

  6. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2, Docket Nos. 50-390 and 50-391, Tennessee Valley Authority. Supplement number 20

    SciTech Connect

    1996-02-01

    This report supplements the Safety Evaluation Report (SER), NUREG-0847 (June 1982), Supplement No. 1 (September 1982), Supplement No. 2 (January 1984), Supplement No. 3 (January 1985), Supplement No. 4 (March 1985), Supplement No. 5 (November 1990), Supplement No. 6 (April 1991), Supplement No. 7 (September 1991), Supplement No. 8 (January 1992), Supplement No. 9 (June 1992), Supplement No. 10 (October 1992), Supplement No. 11 (April 1993), Supplement No. 12 (October 1993), Supplement No. 13 (April 1994), Supplement No. 14 (December 1994), Supplement No. 15 (June 1995), Supplement No. 16 (September 1995), Supplement No. 17 (October 1995), Supplement No. 18 (October 1995), and Supplement No. 19 (November 1995) issued by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission with respect to the application filed by the Tennessee Valley Authority, as applicant and owner, for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). The facility is located in Rhea County, Tennessee, near the Watts Bar Dam on the Tennessee River. This supplement provides recent information regarding resolution of some of the issues identified in the SER.

  7. Safety evaluation report related to the operation of Watts Bar Nuclear Plant, Units 1 and 2 (Docket Nos. 50-390 and 50-391). Supplement No. 18

    SciTech Connect

    Tam, P.S.

    1995-10-01

    In June 1982, the Nuclear Regulatory Commission staff (NRC staff or staff) issued a Safety Evaluation Report, NUREG-0847, regarding the application by the Tennessee Valley Authority (TVA or the applicant) for licenses to operate the Watts Bar Nuclear Plant, Units 1 and 2. Each of the following sections and appendices of this supplement is numbered the same as the section or appendix of the SER that is being updated, and the discussions are supplementary to, and not in lieu of, the discussion in the SER, unless otherwise noted. Accordingly, Appendix A continues the chronology of the safety review. Appendix E lists principal contributors to this supplement. Appendix FF is added in this supplement. The other appendices are not changed by this supplement.

  8. 78 FR 35990 - All Operating Boiling-Water Reactor Licensees With Mark I And Mark II Containments; Docket Nos...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION All Operating Boiling-Water Reactor Licensees With Mark I And Mark II Containments; Docket Nos. (As Shown In Attachment 1), License Nos. (As Shown In Attachment 1), EA-13-109; Order Modifying Licenses With Regard to Reliable Hardened...

  9. 76 FR 54259 - Virginia Electric and Power Company, Docket Nos. 50-338 and 50-339, North Anna Power Station...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Virginia Electric and Power Company, Docket Nos. 50-338 and 50- 339, North Anna Power Station... Duty Programs,'' for Facility Operating License Nos. NPF-4 and NPF-7, issued to Virginia Electric...

  10. 75 FR 13600 - Virginia Electric and Power Company, North Anna Power Station, Unit Nos. 1 and 2, Surry Power...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... COMMISSION [Docket Nos. 50-338 and 50-339, Docket Nos. 50-280 and 50-281, NRC- 2010-0116] Virginia Electric... ``a'' for Facility Operating License Nos. NPF-4, NPF-7, DPR-32, and DPR-37 issued to Virginia Electric... adverse effect on the probability of an accident occurring. The details of the staff's safety...

  11. 75 FR 76495 - Virginia Electric and Power Company North Anna Power Station, Unit Nos. 1 and 2 Surry Power...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... COMMISSION [Docket Nos. 50-338 and 50-339; Docket Nos. 50-280 and 50-281; NRC- 2010-0376] Virginia Electric... License Nos. DPR-32 and DPR-37, issued to Virginia Electric and Power Company (the licensee), for... adverse effect on the probability of an accident occurring. The proposed action would not result in...

  12. 75 FR 53984 - Virginia Electric and Power Company North Anna Power Station, Unit Nos. 1 and 2 Surry Power...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-338 and 50-339, Docket Nos. 50-280 and 50-281, NRC- 2010-0283] Virginia Electric.... DPR-32 and DPR-37, issued to Virginia Electric and Power Company (the licensee), for operation of...

  13. 78 FR 21120 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Acts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ...; Correction AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; correction. SUMMARY: EPA issued a... (7508P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. NW... Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection Agency Docket Center...

  14. 49 CFR 190.305 - Regulatory dockets.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., docketed material may be accessed at http://www.regulations.gov. Public comments also may be submitted at http://www.regulations.gov. Comment submissions must identify the docket number. You may also...

  15. 24 CFR 10.4 - Rules docket.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Rules docket. 10.4 Section 10.4... RULEMAKING: POLICY AND PROCEDURES General § 10.4 Rules docket. (a) All documents relating to rulemaking..., final rules and general notices are maintained in the Rules Docket Room (Room 5218), Department...

  16. 10 CFR 110.102 - Hearing docket.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Hearing docket. 110.102 Section 110.102 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Hearings § 110.102 Hearing docket. For each hearing, the Secretary will maintain a docket which will include the...

  17. 49 CFR 845.50 - Public docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Public docket. 845.50 Section 845.50... RULES OF PRACTICE IN TRANSPORTATION; ACCIDENT/INCIDENT HEARINGS AND REPORTS Public Record § 845.50 Public docket. (a) The public docket shall include all factual information concerning the...

  18. 49 CFR 845.50 - Public docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Public docket. 845.50 Section 845.50... RULES OF PRACTICE IN TRANSPORTATION; ACCIDENT/INCIDENT HEARINGS AND REPORTS Public Record § 845.50 Public docket. (a) The public docket shall include all factual information concerning the...

  19. 7 CFR 900.54 - Docket number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Docket number. 900.54 Section 900.54 Agriculture... Governing Proceedings on Petitions To Modify or To Be Exempted From Marketing Orders § 900.54 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by...

  20. 7 CFR 1.414 - Docket number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Docket number. 1.414 Section 1.414 Agriculture Office... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.414 Docket number. Each proceeding, following its institution, shall be assigned a docket number by the Hearing Clerk, and thereafter...

  1. 7 CFR 900.54 - Docket number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Docket number. 900.54 Section 900.54 Agriculture... Governing Proceedings on Petitions To Modify or To Be Exempted From Marketing Orders § 900.54 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by...

  2. 7 CFR 1.134 - Docket number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing...

  3. 7 CFR 900.54 - Docket number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Docket number. 900.54 Section 900.54 Agriculture... Governing Proceedings on Petitions To Modify or To Be Exempted From Marketing Orders § 900.54 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by...

  4. 7 CFR 1.134 - Docket number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing...

  5. 7 CFR 1.414 - Docket number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Docket number. 1.414 Section 1.414 Agriculture Office... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.414 Docket number. Each proceeding, following its institution, shall be assigned a docket number by the Hearing Clerk, and thereafter...

  6. 7 CFR 1.414 - Docket number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Docket number. 1.414 Section 1.414 Agriculture Office... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.414 Docket number. Each proceeding, following its institution, shall be assigned a docket number by the Hearing Clerk, and thereafter...

  7. 7 CFR 900.54 - Docket number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Docket number. 900.54 Section 900.54 Agriculture... Governing Proceedings on Petitions To Modify or To Be Exempted From Marketing Orders § 900.54 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by...

  8. 7 CFR 1200.6 - Docket number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Docket number. 1200.6 Section 1200.6 Agriculture... Governing Proceedings To Formulate and Amend an Order § 1200.6 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter...

  9. 7 CFR 900.5 - Docket number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Docket number. 900.5 Section 900.5 Agriculture... Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter the proceeding may be referred to by such number....

  10. 7 CFR 900.5 - Docket number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Docket number. 900.5 Section 900.5 Agriculture... Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter the proceeding may be referred to by such number....

  11. 7 CFR 1200.6 - Docket number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Docket number. 1200.6 Section 1200.6 Agriculture... Governing Proceedings To Formulate and Amend an Order § 1200.6 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter...

  12. 7 CFR 900.5 - Docket number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Docket number. 900.5 Section 900.5 Agriculture... Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter the proceeding may be referred to by such number....

  13. 7 CFR 1.414 - Docket number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Docket number. 1.414 Section 1.414 Agriculture Office... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.414 Docket number. Each proceeding, following its institution, shall be assigned a docket number by the Hearing Clerk, and thereafter...

  14. 7 CFR 1.134 - Docket number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing...

  15. 7 CFR 1200.6 - Docket number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Docket number. 1200.6 Section 1200.6 Agriculture... Governing Proceedings To Formulate and Amend an Order § 1200.6 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter...

  16. 7 CFR 1200.6 - Docket number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Docket number. 1200.6 Section 1200.6 Agriculture... Governing Proceedings To Formulate and Amend an Order § 1200.6 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter...

  17. 7 CFR 900.54 - Docket number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Docket number. 900.54 Section 900.54 Agriculture... Governing Proceedings on Petitions To Modify or To Be Exempted From Marketing Orders § 900.54 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by...

  18. 7 CFR 1.414 - Docket number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Docket number. 1.414 Section 1.414 Agriculture Office... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.414 Docket number. Each proceeding, following its institution, shall be assigned a docket number by the Hearing Clerk, and thereafter...

  19. 7 CFR 1.134 - Docket number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing...

  20. 7 CFR 900.5 - Docket number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Docket number. 900.5 Section 900.5 Agriculture... Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter the proceeding may be referred to by such number....

  1. 7 CFR 900.5 - Docket number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Docket number. 900.5 Section 900.5 Agriculture... Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter the proceeding may be referred to by such number....

  2. 7 CFR 1200.6 - Docket number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Docket number. 1200.6 Section 1200.6 Agriculture... Governing Proceedings To Formulate and Amend an Order § 1200.6 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the hearing clerk and thereafter...

  3. 7 CFR 1.134 - Docket number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing...

  4. 49 CFR 211.5 - Regulatory docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Jersey Avenue, SE., Washington, DC 20590. Copies of docketed materials may be obtained upon payment of... electronic storage or printing. There is no charge for this service. (b) Records of the Federal Railroad... FRA's Docket Office, 1200 New Jersey Avenue, SE., Washington, DC 20590. Any person may...

  5. 49 CFR 211.5 - Regulatory docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Jersey Avenue, SE., Washington, DC 20590. Copies of docketed materials may be obtained upon payment of... electronic storage or printing. There is no charge for this service. (b) Records of the Federal Railroad... FRA's Docket Office, 1200 New Jersey Avenue, SE., Washington, DC 20590. Any person may...

  6. 22 CFR 102.27 - Docket.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEPARTMENT OF STATE ECONOMIC AND OTHER FUNCTIONS CIVIL AVIATION Recommendations to the President Under Section 801 of the Federal Aviation Act of 1958 § 102.27 Docket. (a) All comments submitted under this subpart shall reference the number of the Civil Aeronautics Board docket relating to the proceeding...

  7. 22 CFR 102.27 - Docket.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEPARTMENT OF STATE ECONOMIC AND OTHER FUNCTIONS CIVIL AVIATION Recommendations to the President Under Section 801 of the Federal Aviation Act of 1958 § 102.27 Docket. (a) All comments submitted under this subpart shall reference the number of the Civil Aeronautics Board docket relating to the proceeding...

  8. 22 CFR 102.27 - Docket.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DEPARTMENT OF STATE ECONOMIC AND OTHER FUNCTIONS CIVIL AVIATION Recommendations to the President Under Section 801 of the Federal Aviation Act of 1958 § 102.27 Docket. (a) All comments submitted under this subpart shall reference the number of the Civil Aeronautics Board docket relating to the proceeding...

  9. 10 CFR 590.106 - Dockets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Dockets. 590.106 Section 590.106 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.106 Dockets. The FE...

  10. 10 CFR 590.106 - Dockets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Dockets. 590.106 Section 590.106 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.106 Dockets. The FE...

  11. 10 CFR 590.106 - Dockets.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Dockets. 590.106 Section 590.106 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.106 Dockets. The FE...

  12. 10 CFR 590.106 - Dockets.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Dockets. 590.106 Section 590.106 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.106 Dockets. The FE...

  13. 10 CFR 590.106 - Dockets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Dockets. 590.106 Section 590.106 Energy DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS General Provisions § 590.106 Dockets. The FE...

  14. 20 CFR 802.302 - Docketing of appeals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Docketing of appeals. 802.302 Section 802.302 Employees' Benefits BENEFITS REVIEW BOARD, DEPARTMENT OF LABOR RULES OF PRACTICE AND PROCEDURE Procedure for Review Action by the Board § 802.302 Docketing of appeals. (a) Maintenance of dockets. A docket of...

  15. 33 CFR 1.05-25 - Public docket.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Public docket. 1.05-25 Section 1... PROVISIONS Rulemaking § 1.05-25 Public docket. (a) A public docket is maintained electronically for each... Register. Each docket contains copies of every rulemaking document published for the project,...

  16. 33 CFR 1.05-25 - Public docket.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Public docket. 1.05-25 Section 1... PROVISIONS Rulemaking § 1.05-25 Public docket. (a) A public docket is maintained electronically for each... Register. Each docket contains copies of every rulemaking document published for the project,...

  17. 76 FR 38166 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... review docket for cucumber beetle attractant. This pesticide does not currently have any actively... cucumber beetle attractant because this pesticide is not included in any products actively registered...

  18. 49 CFR 389.5 - Regulatory docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULEMAKING PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS General § 389.5 Regulatory docket. (a) Information and...

  19. 49 CFR 389.5 - Regulatory docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULEMAKING PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS General § 389.5 Regulatory docket. (a) Information and...

  20. 7 CFR 1944.412 - Docket preparation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) PROGRAM REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.412 Docket...-Help Technical Assistance Grant Agreement (Exhibit A) 2 1 1-O 1-C Any Personnel Forms to be used 2...

  1. 7 CFR 1944.412 - Docket preparation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) PROGRAM REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.412 Docket...-Help Technical Assistance Grant Agreement (Exhibit A) 2 1 1-O 1-C Any Personnel Forms to be used 2...

  2. 7 CFR 1944.412 - Docket preparation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) PROGRAM REGULATIONS (CONTINUED) HOUSING Self-Help Technical Assistance Grants § 1944.412 Docket...-Help Technical Assistance Grant Agreement (Exhibit A) 2 1 1-O 1-C Any Personnel Forms to be used 2...

  3. 7 CFR 1944.412 - Docket preparation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Docket preparation. 1944.412 Section 1944.412 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED)...

  4. 7 CFR 1944.412 - Docket preparation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Docket preparation. 1944.412 Section 1944.412 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED)...

  5. 49 CFR 845.50 - Public docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Public docket. 845.50 Section 845.50 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD RULES OF PRACTICE IN TRANSPORTATION; ACCIDENT/INCIDENT HEARINGS AND REPORTS Public Record §...

  6. 40 CFR 155.32 - Public docket.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... under development. (2) If the Agency notifies registrants privately in accordance with 40 CFR 154.21 that one or more risk criteria set forth in 40 CFR 154.7 (leading to a special review) may have been... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Public docket. 155.32 Section...

  7. Social Science Docket, 2000-2001.

    ERIC Educational Resources Information Center

    Singer, Alan, Ed.

    2001-01-01

    A joint publication of the New York and New Jersey State Councils for the Social Studies, "Social Science Docket" presents K-12 teachers with resources covering the social science disciplines, including history, economics, political science, sociology, geography, anthropology, and psychology. Each issue includes theme-related and non-themed…

  8. 76 FR 59672 - Notice of Change In IC Docket Numbering Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... the Commission is modifying the numbering system for the docket prefix IC. These IC docket notices... Commission adopted the current IC docket prefix \\1\\ in order to properly track any comments it receives in... the way the IC docket prefix is set up. Beginning on October 1, 2011, IC dockets will continue to...

  9. 76 FR 17646 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... has established registration review dockets for the ] pesticides listed in the table in Unit III.A.... Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues...) number for the specific pesticide of interest provided in the table in Unit III.A., by one of...

  10. 76 FR 60822 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ...EPA has established registration review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is opening the public comment period for these registration reviews. Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy the statutory standard for registration, that is, the pesticide can perform......

  11. 39 CFR 3001.13 - Docket and hearing calendar.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Docket and hearing calendar. 3001.13 Section 3001.13 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES OF PRACTICE AND PROCEDURE Rules of... remotely via the Commission's Web site, or viewed at the Commission's docket section during...

  12. 48 CFR 6302.3 - Docketing of appeals (Rule 3).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Docketing of appeals (Rule 3). 6302.3 Section 6302.3 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION BOARD OF CONTRACT APPEALS RULES OF PROCEDURE 6302.3 Docketing of appeals (Rule 3). Following receipt by...

  13. 10 CFR 2.815 - Docketing and acceptance review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Docketing and acceptance review. 2.815 Section 2.815 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rulemaking § 2.815 Docketing and acceptance review. (a) Each application for a standard...

  14. 10 CFR 205.15 - Public docket room.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Public docket room. 205.15 Section 205.15 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 205.15 Public docket room. There shall be established at the DOE National Office, 12th and Pennsylvania Avenue,...

  15. 7 CFR 1781.17 - Docket preparation and processing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... water and irrigation. (6) Estimates of right-of-way Costs. The docket should include, as part of the... needed. (2) Instructions for preparation of docket. When the Rural Development State Director has... State Conservationist concurring in the feasibility of the WS work of improvement or RCD measure...

  16. 49 CFR 601.43 - Opening the docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Opening the docket. 601.43 Section 601.43 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for Public Transportation Systems § 601.43 Opening the docket....

  17. 33 CFR 1.05-25 - Public docket.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... docket. Public dockets for Coast Guard rulemakings are available electronically at http://www.regulations... http://www.regulations.gov. Paragraph (a) of this section describes how to access and view these... available for inspection at the appropriate Captains of the Port Office or online at...

  18. The NOS Challenge

    ERIC Educational Resources Information Center

    Quigley, Cassie; Buck, Gayle; Akerson, Valarie

    2011-01-01

    "The picture of a scientist is me!" exclaims first grader Kendra during a nature of science (NOS) lesson. She drew a picture of a scientist and explained that she was going to be a scientist when she grew up because she "loved to observe like a scientist." Kendra's experience was a part of a 30-day unit designed specifically for first graders.…

  19. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Order and Dockets Unit. 351.103 Section 351.103 Customs Duties INTERNATIONAL TRADE ADMINISTRATION... Unit and Administrative Protective Order and Dockets Unit. (a) Import Administration's Central Records... Administration's Administrative Protective Order and Dockets Unit (APO/Dockets Unit) is located in Room 1870,...

  20. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Order and Dockets Unit. 351.103 Section 351.103 Customs Duties INTERNATIONAL TRADE ADMINISTRATION... Unit and Administrative Protective Order and Dockets Unit. (a) Import Administration's Central Records... Administration's Administrative Protective Order and Dockets Unit (APO/Dockets Unit) is located in Room 1870,...

  1. 75 FR 62810 - Twenty-Fourth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... facilities not previously listed on the Docket and reported to EPA since the last update of the Docket (73 FR... facilities to be included on the Docket was published in the Federal Register on February 12, 1988 (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR...

  2. 10 CFR 2.815 - Docketing and acceptance review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS Rulemaking § 2.815 Docketing and acceptance review. (a) Each application for a standard design... copy of the tendered application will be available for public inspection at the NRC Web site,...

  3. 7 CFR 15f.8 - What does the Docketing Clerk do with my Section 741 Complaint Request?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... My Complaint Informally With OCR? § 15f.8 What does the Docketing Clerk do with my Section 741 Complaint Request? All Section 741 Complaint Requests docketed by the OCR Docketing Clerk will be...

  4. 7 CFR 15f.8 - What does the Docketing Clerk do with my Section 741 Complaint Request?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... My Complaint Informally With OCR? § 15f.8 What does the Docketing Clerk do with my Section 741 Complaint Request? All Section 741 Complaint Requests docketed by the OCR Docketing Clerk will be...

  5. 7 CFR 15f.8 - What does the Docketing Clerk do with my Section 741 Complaint Request?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... My Complaint Informally With OCR? § 15f.8 What does the Docketing Clerk do with my Section 741 Complaint Request? All Section 741 Complaint Requests docketed by the OCR Docketing Clerk will be...

  6. 7 CFR 15f.8 - What does the Docketing Clerk do with my Section 741 Complaint Request?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... My Complaint Informally With OCR? § 15f.8 What does the Docketing Clerk do with my Section 741 Complaint Request? All Section 741 Complaint Requests docketed by the OCR Docketing Clerk will be...

  7. 7 CFR 15f.8 - What does the Docketing Clerk do with my Section 741 Complaint Request?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... My Complaint Informally With OCR? § 15f.8 What does the Docketing Clerk do with my Section 741 Complaint Request? All Section 741 Complaint Requests docketed by the OCR Docketing Clerk will be...

  8. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Order and Dockets Unit. 351.103 Section 351.103 Customs Duties INTERNATIONAL TRADE ADMINISTRATION... Unit and Administrative Protective Order and Dockets Unit. (a) Import Administration's Central Records... (see § 351.104). (b) Import Administration's Administrative Protective Order and Dockets Unit...

  9. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Order and Dockets Unit. 351.103 Section 351.103 Customs Duties INTERNATIONAL TRADE ADMINISTRATION... Unit and Administrative Protective Order and Dockets Unit. (a) Import Administration's Central Records... (see § 351.104). (b) Import Administration's Administrative Protective Order and Dockets Unit...

  10. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Order and Dockets Unit. 351.103 Section 351.103 Customs Duties INTERNATIONAL TRADE ADMINISTRATION... Unit and Administrative Protective Order and Dockets Unit. (a) Enforcement and Compliance's Central... (see § 351.104). (b) Enforcement and Compliance's Administrative Protective Order and Dockets Unit...

  11. 29 CFR 801.64 - Notice of docketing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Notice of docketing. 801.64 Section 801.64 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Referral for...

  12. 29 CFR 801.64 - Notice of docketing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Notice of docketing. 801.64 Section 801.64 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Referral for...

  13. 29 CFR 801.64 - Notice of docketing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Notice of docketing. 801.64 Section 801.64 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Referral for...

  14. 29 CFR 801.64 - Notice of docketing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Notice of docketing. 801.64 Section 801.64 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Referral for...

  15. 29 CFR 801.64 - Notice of docketing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 801.64 Section 801.64 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Referral for...

  16. 43 CFR 4.103 - Forwarding and docketing of appeals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... mailing (or the date of receipt, if the notice was otherwise conveyed) and within 5 days shall forward said notice of appeal to the Board by certified mail. He shall also promptly notify the Department's... the fact of docketing, together with a copy of these rules, shall be mailed promptly by certified...

  17. 20 CFR 802.302 - Docketing of appeals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... order upon the date on which a notice of appeal is received. Correspondence or further applications in...; publication of decision. The docket of the Board shall be open to public inspection. The Board shall publish its decisions in a form which is readily available for inspection, and shall allow the public...

  18. 20 CFR 802.302 - Docketing of appeals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... order upon the date on which a notice of appeal is received. Correspondence or further applications in...; publication of decision. The docket of the Board shall be open to public inspection. The Board shall publish its decisions in a form which is readily available for inspection, and shall allow the public...

  19. 20 CFR 802.302 - Docketing of appeals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... order upon the date on which a notice of appeal is received. Correspondence or further applications in...; publication of decision. The docket of the Board shall be open to public inspection. The Board shall publish its decisions in a form which is readily available for inspection, and shall allow the public...

  20. 47 CFR 1.730 - The Enforcement Bureau's Accelerated Docket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... which raise issues that may not be decided on delegated authority (see 47 U.S.C. 155(c)(1); 47 CFR 0.291... 47 Telecommunication 1 2012-10-01 2012-10-01 false The Enforcement Bureau's Accelerated Docket. 1.730 Section 1.730 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND...

  1. 47 CFR 1.730 - The Enforcement Bureau's Accelerated Docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... which raise issues that may not be decided on delegated authority (see 47 U.S.C. 155(c)(1); 47 CFR 0.291... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Enforcement Bureau's Accelerated Docket. 1.730 Section 1.730 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND...

  2. 47 CFR 1.730 - The Enforcement Bureau's Accelerated Docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... which raise issues that may not be decided on delegated authority (see 47 U.S.C. 155(c)(1); 47 CFR 0.291... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Enforcement Bureau's Accelerated Docket. 1.730 Section 1.730 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND...

  3. 47 CFR 1.730 - The Enforcement Bureau's Accelerated Docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... which raise issues that may not be decided on delegated authority (see 47 U.S.C. 155(c)(1); 47 CFR 0.291... 47 Telecommunication 1 2011-10-01 2011-10-01 false The Enforcement Bureau's Accelerated Docket. 1.730 Section 1.730 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND...

  4. 29 CFR 500.225 - Notice of docketing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 500.225 Section 500.225 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Administrative Proceedings Referral for Hearing § 500.225 Notice...

  5. 29 CFR 500.225 - Notice of docketing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Notice of docketing. 500.225 Section 500.225 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Administrative Proceedings Referral for Hearing § 500.225 Notice...

  6. 29 CFR 501.38 - Notice of docketing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Notice of docketing. 501.38 Section 501.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF...

  7. 29 CFR 501.38 - Notice of docketing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 501.38 Section 501.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF...

  8. 49 CFR 601.42 - Emergency relief docket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Emergency relief docket. 601.42 Section 601.42 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  9. 49 CFR 601.44 - Posting to the docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Posting to the docket. 601.44 Section 601.44 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  10. 49 CFR 601.42 - Emergency relief docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Emergency relief docket. 601.42 Section 601.42 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  11. 49 CFR 601.42 - Emergency relief docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Emergency relief docket. 601.42 Section 601.42 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  12. 49 CFR 601.42 - Emergency relief docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Emergency relief docket. 601.42 Section 601.42 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  13. 49 CFR 601.43 - Opening the docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Opening the docket. 601.43 Section 601.43 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  14. 49 CFR 601.43 - Opening the docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Opening the docket. 601.43 Section 601.43 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  15. 49 CFR 601.44 - Posting to the docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Posting to the docket. 601.44 Section 601.44 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  16. 49 CFR 601.44 - Posting to the docket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Posting to the docket. 601.44 Section 601.44 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  17. 49 CFR 601.44 - Posting to the docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Posting to the docket. 601.44 Section 601.44 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  18. 49 CFR 601.43 - Opening the docket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Opening the docket. 601.43 Section 601.43 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  19. 49 CFR 601.42 - Emergency relief docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Emergency relief docket. 601.42 Section 601.42 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for Public Transportation Systems § 601.42 Emergency...

  20. 49 CFR 601.44 - Posting to the docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Posting to the docket. 601.44 Section 601.44 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for Public Transportation Systems § 601.44 Posting to...

  1. 49 CFR 601.43 - Opening the docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Opening the docket. 601.43 Section 601.43 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for...

  2. 39 CFR 3020.53 - Docket and notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service POSTAL REGULATORY COMMISSION PERSONNEL PRODUCT LISTS Requests Initiated by Users of the Mail To Modify the Product Lists Described Within the Mail Classification Schedule § 3020.53 Docket and notice... competitive product list, promptly publish notice of the request in the Federal Register, and post the...

  3. 39 CFR 3020.33 - Docket and notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service POSTAL REGULATORY COMMISSION PERSONNEL PRODUCT LISTS Requests Initiated by the Postal Service To Modify the Product Lists Described Within the Mail Classification Schedule § 3020.33 Docket and notice... competitive product list, promptly publish notice of the request in the Federal Register, and post the...

  4. 39 CFR 3020.73 - Docket and notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service POSTAL REGULATORY COMMISSION PERSONNEL PRODUCT LISTS Proposal of the Commission To Modify the Product Lists Described Within the Mail Classification Schedule § 3020.73 Docket and notice. The... product list, promptly publish notice of the request in the Federal Register, and post the filing on...

  5. 39 CFR 3020.53 - Docket and notice.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  6. 39 CFR 3020.33 - Docket and notice.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  7. 39 CFR 3020.73 - Docket and notice.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A reference to...

  8. 39 CFR 3020.33 - Docket and notice.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  9. 39 CFR 3020.73 - Docket and notice.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A reference to...

  10. 39 CFR 3020.73 - Docket and notice.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A reference to...

  11. 39 CFR 3020.33 - Docket and notice.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  12. 39 CFR 3020.53 - Docket and notice.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  13. 39 CFR 3020.53 - Docket and notice.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  14. 39 CFR 3020.33 - Docket and notice.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  15. 39 CFR 3020.73 - Docket and notice.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A reference to...

  16. 39 CFR 3020.53 - Docket and notice.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... The Commission will establish a docket for each request to modify the market dominant list or the competitive product list, promptly publish notice of the request in the Federal Register, and post the filing on its Web site. The notice shall include: (a) The general nature of the proceeding; (b) A...

  17. Evaluation of docket files for terminated source material licenses

    SciTech Connect

    Holoway, C.F.; Lantz, P.M.; Dickson, H.W.

    1980-01-01

    Terminated source material licenses from docket files of the Nuclear Regulatory Commission (NRC) have been evaluated with respect to the potential for residual radiological health problems. Some 8,275 source material docket files were sent from the Federal Repository for NRC to Oak Ridge National Laboratory for evaluation. An NRC printed inventory of terminated source material licenses was sent separately and input to a computer file for ready access. The files were inventoried and a methodology was developed for evaluation of these files. The methodology included development of a combined analysis/computer input form. Pertinent data were abstracted from each file, placed on this form, and entered into a separate private-access computer file. At the same time, analysts using screening criteria made a preliminary categorization of the files. All files categorized initially as potential radiological health problems were reviewed in depth to arrive at a final categorization. Criteria for judgment included quantities of source material (uranium and/or thorium) going to and leaving the site in question during the operational lifetime of the site, disposition of source material not leaving the site, types of operations carried on at the site during the licensed period, and the physicochemical forms of products and wastes involved. In the final analysis, 193 dockets were identified as having potential for residual radiological health problems.

  18. 78 FR 35984 - Interim Eligible Class of NRC-Licensed Facilities; Docket Nos. (as Shown in Attachment 1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... Section 161A took effect on September 11, 2009, with publication in the Federal Register (FR) of the...'' (74 FR 46800; September 11, 2009) (referred to as ``Firearms Guidelines''). The NRC is issuing EA-13..., Radioactive Material, and Other Property,'' (74 FR 46800; September 11, 2009) (``Firearms Guidelines''))...

  19. 78 FR 40142 - Office of Managing Director Creates Docket for Petitions Seeking Review of Application Fee Refund...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ...The Office of Managing Director has created the new docket shown above for petitions seeking review of application fee refund denials. Consolidating all these related pleadings in a separate docket will promote administrative efficiency and enhance public accessibility to these...

  20. 44 CFR 67.3 - Establishment and maintenance of a flood elevation determination docket (FEDD).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of a flood elevation determination docket (FEDD). 67.3 Section 67.3 Emergency Management and... MITIGATION National Flood Insurance Program APPEALS FROM PROPOSED FLOOD ELEVATION DETERMINATIONS § 67.3 Establishment and maintenance of a flood elevation determination docket (FEDD). The Federal...

  1. 44 CFR 67.3 - Establishment and maintenance of a flood elevation determination docket (FEDD).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of a flood elevation determination docket (FEDD). 67.3 Section 67.3 Emergency Management and... MITIGATION National Flood Insurance Program APPEALS FROM PROPOSED FLOOD ELEVATION DETERMINATIONS § 67.3 Establishment and maintenance of a flood elevation determination docket (FEDD). The Federal...

  2. 44 CFR 67.3 - Establishment and maintenance of a flood elevation determination docket (FEDD).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of a flood elevation determination docket (FEDD). 67.3 Section 67.3 Emergency Management and... MITIGATION National Flood Insurance Program APPEALS FROM PROPOSED FLOOD ELEVATION DETERMINATIONS § 67.3 Establishment and maintenance of a flood elevation determination docket (FEDD). The Federal...

  3. 44 CFR 66.3 - Establishment of community case file and flood elevation study docket.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... case file and flood elevation study docket. 66.3 Section 66.3 Emergency Management and Assistance... National Flood Insurance Program CONSULTATION WITH LOCAL OFFICIALS § 66.3 Establishment of community case file and flood elevation study docket. (a) A file shall be established for each community at the...

  4. Docket Search. Part of a Planning Document for the Establishment of a Nationwide Educational Telecommunications System.

    ERIC Educational Resources Information Center

    Synergetics, Inc., Washington, DC.

    A docket search reviews selected educational telecommunications issues brought to the attention of the Federal Communications Commission (FCC). The docket search was part of an effort to develop a planning document for the establishment of a nationwide educational telecommunications system. Key policy-making proceedings were identified which dealt…

  5. 44 CFR 67.3 - Establishment and maintenance of a flood elevation determination docket (FEDD).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of a flood elevation determination docket (FEDD). 67.3 Section 67.3 Emergency Management and... MITIGATION National Flood Insurance Program APPEALS FROM PROPOSED FLOOD ELEVATION DETERMINATIONS § 67.3 Establishment and maintenance of a flood elevation determination docket (FEDD). The Federal...

  6. 44 CFR 66.3 - Establishment of community case file and flood elevation study docket.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... case file and flood elevation study docket. 66.3 Section 66.3 Emergency Management and Assistance... National Flood Insurance Program CONSULTATION WITH LOCAL OFFICIALS § 66.3 Establishment of community case file and flood elevation study docket. (a) A file shall be established for each community at the...

  7. 76 FR 18750 - Ocean Renewable Power Company, LLC; Notice of Change in Docket Number

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... Energy Regulatory Commission Ocean Renewable Power Company, LLC; Notice of Change in Docket Number On July 24, 2009, Ocean Renewable Power Company, LLC (ORPC) filed a draft hydrokinetic pilot license... of this change in docket number, all current filings and issuances associated with the Eastport...

  8. 46 CFR 502.271 - Special docket application for permission to refund or waive freight charges.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 9 2011-10-01 2011-10-01 false Special docket application for permission to refund or waive freight charges. 502.271 Section 502.271 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Refund or Waiver of Freight Charges § 502.271 Special docket application for permission to...

  9. 33 CFR 148.207 - How and where may I view docketed documents?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Docket Management System Web site at http://www.dot.dms.gov. The projects are also listed by name and the assigned docket number at the G-PSO-5 Web site: http://www.uscg.mil/hq/g-m/mso/mso5.htm....

  10. 78 FR 60868 - Amendment of the Federal Docket Management System (EPA/GOV-2)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... AGENCY Amendment of the Federal Docket Management System (EPA/GOV-2) AGENCY: Environmental Protection...-HQ- OEI-2012-0483 by one of the following methods: www.regulations.gov : Follow the online instructions for submitting comments. Email: oei.docket@epa.gov . Fax: 202-566-1752. Mail: OEI...

  11. 77 FR 5293 - Establishment of an Emergency Relief Docket for Calendar Year 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ..., regulations, or standards during an emergency situation or event. 74 FR 23329. That direct final rule became... Federal Railroad Administration Establishment of an Emergency Relief Docket for Calendar Year 2012 AGENCY...: This Notice announces the establishment of FRA's emergency relief docket (ERD) for calendar year...

  12. 10 CFR 2.643 - Acceptance and docketing of application for limited work authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Acceptance and docketing of application for limited work... Construct Certain Utilization Facilities; and Advance Issuance of Limited Work Authorizations Phased Applications Involving Limited Work Authorizations § 2.643 Acceptance and docketing of application for...

  13. 78 FR 16824 - Tobacco Product Manufacturing Practice; Establishment of a Public Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... docket to obtain input on recommendations for regulations on good manufacturing practice for tobacco... current good manufacturing practice, or hazard analysis and critical control point methodology.'' On... Product Good Manufacturing Practices Regulation and Request for Meeting, submitted to FDA, January...

  14. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    PubMed Central

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  15. 20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .... Each docketed appeal will be assigned a number in chronological order based upon the date on which the notice of appeal is received. While the Board generally hears appeals in the order docketed, the Board retains discretion to change the order in which a particular appeal will be considered. The Clerk...

  16. 20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .... Each docketed appeal will be assigned a number in chronological order based upon the date on which the notice of appeal is received. While the Board generally hears appeals in the order docketed, the Board retains discretion to change the order in which a particular appeal will be considered. The Clerk...

  17. 20 CFR 501.8 - Clerk of the Office of the Appellate Boards; docket of proceedings; records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .... Each docketed appeal will be assigned a number in chronological order based upon the date on which the notice of appeal is received. While the Board generally hears appeals in the order docketed, the Board retains discretion to change the order in which a particular appeal will be considered. The Clerk...

  18. 49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... For information regarding the types of documents routinely issued by the Board, see 49 CFR part 801... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's...

  19. 49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... For information regarding the types of documents routinely issued by the Board, see 49 CFR part 801... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's...

  20. 49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... For information regarding the types of documents routinely issued by the Board, see 49 CFR part 801... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's...

  1. 49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... For information regarding the types of documents routinely issued by the Board, see 49 CFR part 801... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's...

  2. 49 CFR 837.3 - Published reports, material contained in the public accident investigation dockets, and accident...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... For information regarding the types of documents routinely issued by the Board, see 49 CFR part 801... public accident investigation dockets, and accident database data. 837.3 Section 837.3 Transportation... investigation dockets, and accident database data. (a) Demands for material contained in the NTSB's...

  3. 48 CFR 6101.2 - Filing cases; time limits for filing; notice of docketing; consolidation [Rule 2].

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Filing cases; time limits for filing; notice of docketing; consolidation . 6101.2 Section 6101.2 Federal Acquisition Regulations... Filing cases; time limits for filing; notice of docketing; consolidation . (a) Filing cases. Filing of...

  4. 42 CFR 426.470 - Board's role in docketing and evaluating the acceptability of appeals of ALJ decisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Board's role in docketing and evaluating the acceptability of appeals of ALJ decisions. 426.470 Section 426.470 Public Health CENTERS FOR MEDICARE & MEDICAID... DETERMINATIONS AND LOCAL COVERAGE DETERMINATIONS Review of an LCD § 426.470 Board's role in docketing...

  5. 76 FR 77994 - Brian Hamilton v. El Paso Natural Gas, El Paso Western Pipelines; Notice Announcing Docket Number...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Brian Hamilton v. El Paso Natural Gas, El Paso Western Pipelines; Notice Announcing Docket Number Change On December 2, 2011, the Commission issued a notice in docket number...

  6. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you...

  7. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you...

  8. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you...

  9. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you...

  10. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive security information. You should not submit sensitive security information to the rulemaking docket, unless you...

  11. On the selectivity of neuronal NOS inhibitors

    PubMed Central

    Pigott, B; Bartus, K; Garthwaite, J

    2013-01-01

    Background and Purpose Isoform-selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl-l-N-5-(1-imino-3-butenyl)-l-ornithine (l-VNIO) and Nω-propyl-l-arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under cell-free conditions, as does N-[(3-aminomethyl)benzyl]acetamidine (1400W), which is primarily an inducible NOS inhibitor. Although used in numerous investigations in vitro and in vivo, there have been surprisingly few tests of the potency and selectivity of these compounds in cells. This study addresses this deficiency and evaluates the activity of new and potentially better pyrrolidine-based compounds. Experimental Approach The inhibitors were evaluated by measuring their effect on NMDA-evoked cGMP accumulation in rodent hippocampal slices, a response dependent on neuronal NOS, and ACh-evoked cGMP synthesis in aortic rings of the same animals, an endothelial NOS-dependent phenomenon. Key Results l-VNIO, NPA and 1400W inhibited responses in both tissues but all showed less than fivefold higher potency in the hippocampus than in the aorta, implying useless selectivity for neuronal over endothelial NOS at the tissue level. In addition, the inhibitors had a 25-fold lower potency in the hippocampus than reported previously, the IC50 values being approximately 1 μM for l-VNIO and NPA, and 150 μM for 1400W. Pyrrolidine-based inhibitors were similarly weak and nonselective. Conclusion and Implications The results suggest that l-VNIO, NPA and 1400W, as well as the newer pyrrolidine-type inhibitors, cannot be used as neuronal NOS inhibitors in cells without stringent verification. The identification of inhibitors with useable selectivity in cells and tissues remains an important goal. PMID:23072468

  12. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    ERIC Educational Resources Information Center

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  13. mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

    PubMed Central

    Colton, Carol A.; Wilson, Joan G.; Everhart, Angela; Wilcock, Donna M.; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P.

    2014-01-01

    Abstract Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI+/+/mNos2−/− (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI+/−/HuNOS2tg+/+/mNos2−/−) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  14. mNos2 deletion and human NOS2 replacement in Alzheimer disease models.

    PubMed

    Colton, Carol A; Wilson, Joan G; Everhart, Angela; Wilcock, Donna M; Puoliväli, Jukka; Heikkinen, Taneli; Oksman, Juho; Jääskeläinen, Olli; Lehtimäki, Kimmo; Laitinen, Teemu; Vartiainen, Nina; Vitek, Michael P

    2014-08-01

    Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric oxide levels produced by immune activation of the NOS2 gene. Using the APPSwDI(+)/(+)mNos2(-/-) (CVN-AD) mouse strain, we show a sequence of pathologic events leading to neurodegeneration,which include pathologically hyperphosphorylated tau in the perforant pathway at 6 weeks of age progressing to insoluble tau, early appearance of β-amyloid peptides in perivascular deposits around blood vessels in brain regions known to be vulnerable to Alzheimer disease, and progression to damage and overt loss in select vulnerable neuronal populations in these regions. The role of species differences between hNOS2 and mNos2 was supported by generating mice in which the human NOS2 gene replaced mNos2. When crossed with CVN-AD mice, pathologic characteristics of this new strain (APPSwDI(+)/(-)/HuNOS2(tg+)/(+)/mNos2(-/-)) mimicked the pathologic phenotypes found in the CVN-AD strain. PMID:25003233

  15. 15 CFR 400.32 - Procedures for docketing applications and commencement of case review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Procedures for docketing applications and commencement of case review. 400.32 Section 400.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF...

  16. 15 CFR 400.31 - General application provisions and pre-docketing review.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false General application provisions and pre-docketing review. 400.31 Section 400.31 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF COMMERCE REGULATIONS OF THE...

  17. 15 CFR 400.31 - General application provisions and pre-docketing review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false General application provisions and pre-docketing review. 400.31 Section 400.31 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF COMMERCE REGULATIONS OF THE...

  18. 15 CFR 400.32 - Procedures for docketing applications and commencement of case review.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Procedures for docketing applications and commencement of case review. 400.32 Section 400.32 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF...

  19. 78 FR 16668 - Twenty-Fifth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... 12, 1988 (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR 46364); December 15, 1989 (54 FR 51472); August 22, 1990 (55 FR 34492); September 27, 1991 (56 FR 49328); December 12, 1991 (56 FR 64898); July 17, 1992 (57 FR 31758); February 5, 1993 (58 FR...

  20. 78 FR 56947 - Prairie Island; Independent Spent Fuel Storage Installation; Notice of Docketing of Amendment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... accordance with the NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires... that the filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28, 2007) apply to appeals... COMMISSION Prairie Island; Independent Spent Fuel Storage Installation; Notice of Docketing of...

  1. 76 FR 80980 - Notice of Acceptance for Docketing of the Application, Notice of Opportunity for Hearing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Acceptance for Docketing of the Application, Notice of Opportunity for...

  2. 44 CFR 66.3 - Establishment of community case file and flood elevation study docket.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... case file and flood elevation study docket. 66.3 Section 66.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION... placed in the community file. Even if a map is administratively rescinded or withdrawn after notice...

  3. 44 CFR 66.3 - Establishment of community case file and flood elevation study docket.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... case file and flood elevation study docket. 66.3 Section 66.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION... placed in the community file. Even if a map is administratively rescinded or withdrawn after notice...

  4. 44 CFR 66.3 - Establishment of community case file and flood elevation study docket.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... case file and flood elevation study docket. 66.3 Section 66.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION... placed in the community file. Even if a map is administratively rescinded or withdrawn after notice...

  5. 33 CFR 148.207 - How and where may I view docketed documents?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false How and where may I view docketed documents? 148.207 Section 148.207 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: GENERAL Processing Applications General § 148.207 How and where may I view...

  6. 77 FR 5088 - Notice of Establishment of Emergency Relief Docket for Calendar Year 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... 604.2(f) of FTA's charter rule (73 FR 2325, Jan. 14, 2008), grantees and subgrantees may assist with... Federal Transit Administration Notice of Establishment of Emergency Relief Docket for Calendar Year 2012 AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice. SUMMARY: The Federal...

  7. 78 FR 11268 - Notice of Establishment of Emergency Relief Docket for Calendar Year 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... charter rule (73 FR 2325, Jan. 14, 2008), grantees and subgrantees may assist with evacuations or other... Federal Transit Administration Notice of Establishment of Emergency Relief Docket for Calendar Year 2013 AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice SUMMARY: The Federal...

  8. 76 FR 31606 - Cryolite Registration Review Docket; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... of March 30, 2011 (76 FR 17646) (FRL-8868-9). In that document, the Agency announced the availability... AGENCY Cryolite Registration Review Docket; Extension of Comment Period AGENCY: Environmental Protection... comment, including cryolite. This document extends the comment period for the cryolite registration...

  9. 76 FR 79173 - Registration Review; Pesticide Dockets Opened for Review and Comment, and Notice of Availability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... of Final Work Plans for Certain Pesticides AGENCY: Environmental Protection Agency (EPA). ACTION... availability of amended final work plans for the registration review of the pesticides cryolite, prodiamine... amended final work plans for the registration review of the pesticides cryolite (docket EPA-HQ-OPP-...

  10. 75 FR 16100 - Antimicrobial Pesticide Registration Review Dockets Opened for Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...EPA has established registration review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is opening the public comment period for these registration reviews. Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy the statutory standard for registration, that is, the pesticide can perform......

  11. 75 FR 16117 - Registration Review; Pesticide Dockets Opened for Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...EPA has established registration review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is opening the public comment period for these registration reviews. Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy the statutory standard for registration, that is, the pesticide can perform......

  12. 75 FR 60119 - Registration Review; Antimicrobial Pesticide Dockets Opened for Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... for the pesticides listed in the table in Unit III.A. With this document, EPA is opening the public comment period for these registration reviews. Registration review is EPA's periodic review of pesticide... docket identification (ID) number for the specific pesticide of interest provided in the table in...

  13. 75 FR 38521 - Registration Review; Biopesticide Dockets Opened for Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... registration review dockets for the pesticides listed in the table in Unit III.A. of this notice. With this... EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy... specific pesticide of interest provided in the table in Unit III.A. of this notice, by one of the...

  14. 75 FR 16114 - Registration Review; Biopesticides Dockets Opened for Review and Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...EPA has established registration review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is opening the public comment period for these registration reviews. Registration review is EPA's periodic review of pesticide registrations to ensure that each pesticide continues to satisfy the statutory standard for registration, that is, the pesticide can perform......

  15. 75 FR 2163 - Constellation Energy; Notice of Docketing of Special Nuclear Material License SNM-2505 Amendment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... COMMISSION Constellation Energy; Notice of Docketing of Special Nuclear Material License SNM-2505 Amendment... June 15, 2009, from Constellation Energy (Constellation) to amend its Special Nuclear Material License... will remain the same for this action. An NRC review, documented in a letter to Constellation dated...

  16. 77 FR 66609 - Twenty-Fifth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR 46364); December 15, 1989 (54 FR 51472); August 22, 1990 (55 FR 34492); September 27, 1991 (56 FR 49328); December 12, 1991 (56 FR 64898); July 17, 1992 (57 FR 31758); February 5, 1993 (58 FR 7298); November 10,...

  17. 40 CFR 1612.3 - Published reports and material contained in the public incident investigation dockets.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Published reports and material... Published reports and material contained in the public incident investigation dockets. (a) Demands for published investigation reports should be directed to the Office of Congressional and Public Affairs,...

  18. An evolutionarily ancient NO synthase (NOS) in shrimp.

    PubMed

    Wu, Chun-Hung; Siva, Vinu S; Song, Yen-Ling

    2013-11-01

    Nitric oxide (NO) is a well known essential molecule that is involved in multiple functions such as neuron transduction, cardiac disease, immune responses, etc.; nitric oxide synthase (NOS) is a critical enzyme that catalyzes the synthesis of it. A very few crustacean NOS molecules were biochemically characterized so far. In the present study, we cloned and characterized a NOS cDNA from haemocytes of tiger shrimp (Penaeus monodon) (PmNOS). The full-length of PmNOS cDNA contained 3997 bp, including a 5'UTR of 249 bp, ORF of 3582 bp and a 3'UTR of 166 bp. The putative peptide was 1193 amino acid residues in length, with an estimated molecular weight of 134.7 kDa and pI 6.7. Structurally, PmNOS contained oxygenase and reductase domains at N-terminal and C-terminal, respectively, and connected with a calmodulin binding motif. The deduced amino acid sequence of PmNOS shared 98% identical to the Chinese shrimp (Fenneropenaeus chinensis) NOS. Phylogenetically, PmNOS clustered with invertebrate NOS, but not clustered with iNOS, eNOS or nNOS found in vertebrates. PmNOS mRNA was expressed in many tissues or organs including thoracic and ventral nerves, midgut, gill, eyestalk, haemocytes, subcuticular epithelium and heart, but not found in hepatopancreas, muscle and lymphoid organ. But there was no significant difference in PmNOS mRNA expression after stimulation with LPS either by different concentration or time course or against CpG-ODN 2006. The enzyme activities of rPmNOS or crude homogenates from different tissues were detected, and were shown its highest activity in thoracic and ventral nerves, moderate in midgut and haemocytes but the lowest activity were seen in muscle. The addition of NOS antibody against NADPH binding domain leads to less activity which suggested that NADPH was an essential cofactor for PmNOS catalytic activity. The calcium dependency of PmNOS was ascertained using calmodulin inhibitor, Trifluroperazine. To confirm the population of haemocyte which

  19. 15 CFR Supplement Nos. 3-4 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 3-4 to Part 742 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF... CONTROLS Supplement Nos. 3-4 to Part 742...

  20. Report of the South Texas Project Allegations Review Team. Docket Nos. 50-498 and 50-499, Houston Lighting and Power Company et al.

    SciTech Connect

    Kokajko, L.; Skay, D.; Wang, H.; Murphy, D.

    1995-03-01

    This report provides the results of the South Texas Project Allegations Review Team of the US Nuclear Regulatory Commission. This team was formed to obtain and review allegations from individuals represented by three attorneys who had contacted Congressional staff members. The allegers were employed in various capacities at South Texas Project Electric Generating Station, licensed by Houston Lighting and Power Company, et al.; therefore, the allegations are confined to this site. The South Texas Project Allegations Review Team reviewed, referred, and dispositioned concerns related to discriminatory issues (harassment and intimidation), falsification of records and omission of information, and various technical issues. The team was able to substantiate certain technical issues of minor safety significance or regulatory concern at the South Texas Project facility, but it did not find widespread discriminatory practices such as harassment and intimidation.

  1. NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

    PubMed

    Kleinschnitz, Christoph; Mencl, Stine; Kleikers, Pamela Wm; Schuhmann, Michael K; G López, Manuela; Casas, Ana I; Sürün, Bilge; Reif, Andreas; Schmidt, Harald Hhw

    2016-09-01

    Promising results have been reported in preclinical stroke target validation for pharmacological principles that disrupt the N-methyl-D-aspartate receptor-post-synaptic density protein-95-neuronal nitric oxide synthase complex. However, post-synaptic density protein-95 is also coupled to potentially neuroprotective mechanisms. As post-synaptic density protein-95 inhibitors may interfere with potentially neuroprotective mechanisms and sufficient validation has often been an issue in translating basic stroke research, we wanted to close that gap by comparing post-synaptic density protein-95 inhibitors with NOS1(-/-) mice and a NOS inhibitor. We confirm the deleterious role of NOS1 in stroke both in vivo and in vitro, but find three pharmacological post-synaptic density protein-95 inhibitors to be therapeutically ineffective. PMID:27354091

  2. SS focused technology: Gateways and NOS's

    NASA Technical Reports Server (NTRS)

    Hartenstein, R.

    1985-01-01

    The extensions and enhancements of the fiber optic data bus technology supported by the Space Station Focused Technology Program are discussed. This includes the operating software for the network called the Network Operating System (NOS); gateways and bridges for multiple network topologies; and very large scale topology implimentations to shrink the size and power of the Bus Interface Unit (BIU) down to more manageable dimensions. CMOS is being investigated for the lower speed (parallel) logic. Gallium arsendide is being studied for the high speed (serial) logic.

  3. The dual role of iNOS in cancer☆

    PubMed Central

    Vanini, Frederica; Kashfi, Khosrow; Nath, Niharika

    2015-01-01

    Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous free radical whose predominant functions is that of a messenger through cGMP. In mammals, NO is synthesized by the enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. In many tumors, iNOS expression is high, however, the role of iNOS during tumor development is very complex and quite perplexing, with both promoting and inhibiting actions having been described. This review will aim to summarize the dual actions of iNOS-derived NO showing that the microenvironment of the tumor is a contributing factor to these observations and ultimately to cellular outcomes. PMID:26335399

  4. Specifying PDD-NOS: A Comparison of PDD-NOS, Asperger Syndrome, and Autism

    ERIC Educational Resources Information Center

    Walker, Darlene R.; Thompson, Ann; Zwaigenbaum, Lonnie; Goldberg, Jeremy; Bryson, Susan E.; Mahoney, William J.; Strawbridge, Christina P.; Szatmari, Peter

    2004-01-01

    Objective: To describe the clinical characteristics of children given a diagnosis of pervasive developmental disorder-not otherwise specified (PDD-NOS) by expert clinicians and to compare these to the clinical characteristics of children given a diagnosis of autism and Asperger syndrome (AS). Method: Two hundred sixteen children with autism, 33…

  5. A Scallop Nitric Oxide Synthase (NOS) with Structure Similar to Neuronal NOS and Its Involvement in the Immune Defense

    PubMed Central

    Jiang, Qiufen; Zhou, Zhi; Wang, Leilei; Wang, Lingling; Yue, Feng; Wang, Jingjing; Song, Linsheng

    2013-01-01

    Background Nitric oxide synthase (NOS) is responsible for synthesizing nitric oxide (NO) from L-arginine, and involved in multiple physiological functions. However, its immunological role in mollusc was seldom reported. Methodology In the present study, an NOS (CfNOS) gene was identified from the scallop Chlamys farreri encoding a polypeptide of 1486 amino acids. Its amino acid sequence shared 50.0~54.7, 40.7~47.0 and 42.5~44.5% similarities with vertebrate neuronal (n), endothelial (e) and inducible (i) NOSs, respectively. CfNOS contained PDZ, oxygenase and reductase domains, which resembled those in nNOS. The CfNOS mRNA transcripts expressed in all embryos and larvae after the 2-cell embryo stage, and were detectable in all tested tissues with the highest level in the gonad, and with the immune tissues hepatopancreas and haemocytes included. Moreover, the immunoreactive area of CfNOS distributed over the haemocyte cytoplasm and cell membrane. After LPS, β-glucan and PGN stimulation, the expression level of CfNOS mRNA in haemocytes increased significantly at 3 h (4.0-, 4.8- and 2.7-fold, respectively, P < 0.01), and reached the peak at 12 h (15.3- and 27.6-fold for LPS and β-glucan respectively, P < 0.01) and 24 h (17.3-fold for PGN, P < 0.01). In addition, TNF-α also induced the expression of CfNOS, which started to increase at 1 h (5.2-fold, P < 0.05) and peaked at 6 h (19.9-fold, P < 0.01). The catalytic activity of the native CfNOS protein was 30.3 ± 0.3 U mgprot-1, and it decreased significantly after the addition of the selective inhibitors of nNOS and iNOS (26.9 ± 0.4 and 29.3 ± 0.1 U mgprot-1, respectively, P < 0.01). Conclusions These results suggested that CfNOS, with identical structure with nNOS and similar enzymatic characteristics to nNOS and iNOS, played the immunological role of iNOS to be involved in the scallop immune defense against PAMPs and TNF-α. PMID:23922688

  6. 75 FR 42436 - Houston Pipe Line Company LP-Bammel Storage, Docket No. PR10-51-000, et. al.; Notice of Baseline...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Houston Pipe Line Company LP--Bammel Storage, Docket No. PR10-51- 000, et. al.; Notice of Baseline Filings July 14, 2010. Houston Pipe Line Company LP-- Docket No....

  7. Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts.

    PubMed

    Tenorio-Lopez, Fermin Alejandro; Valle Mondragon, Leonardo Del; Olvera, Gabriela Zarco; Torres Narvaez, Juan Carlos; Pastelin, Gustavo

    2006-11-01

    Viscum album L. aqueous extract, on the Langendorff isolated and perfused heart model, decreases coronary vascular resistance, when compared to control group (36.00 +/- 2.00 vs. 15.80 +/- 1.96 dyn s cm-5). Our data support the fact that this mechanism involves NOS-2 and NOS-3 overexpression (4.65 and 7.89 times over control, respectively), which is correlated with increases in NO (6.24 +/- 2.49 vs. 147.95 +/- 2.79 pmol) and cGMP production (43.94 +/- 2.00 vs. 74.81 +/- 1.96 pmol mg-1 of tissue), compared to control values. Such an effect is antagonized by gadolinium(III) chloride, L-NAME and ODQ. Therefore, coronary vasodilator effect elicited by V. album L. aqueous extract is mediated by the NO/sGC pathway. PMID:17127505

  8. Advancing the perceptions of the nature of science (NOS): integrating teaching the NOS in a science content course

    NASA Astrophysics Data System (ADS)

    Aflalo, Ester

    2014-09-01

    Background:Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose:The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores the effects of another approach to teaching that combines teaching the NOS in a course of scientific content. Sample and Programmed description:109 preservice teachers studied the course on 'Cell Biology' or the course, 'Introduction to Life Sciences', whose teaching model differs. In addition to the usual subject matter the courses included activities to understand some aspects of the NOS, reflective discussions, as well as historical descriptions of the scientific discoveries and developments pertaining to the course matter. Design and methods:The study has characteristics of action research The perceptions of the NOS amongst preservice teachers were examined prior to, and following, the course. The perceptions were examined through 35 closed questions and one open question. Results:The findings show that following the course, some of the concepts of NOS changed. Naïve and conservative acuity developed into more current perceptions towards the NOS. Similarly, there was greater internalization of the meaning of the NOS and the significance of its teaching. Conclusions:The findings of this research discuss evidence of the importance of combining the teaching of the NOS in scientific courses in order to advance scientific literacy.

  9. Face and Emotion Recognition in MCDD versus PDD-NOS

    ERIC Educational Resources Information Center

    Herba, Catherine M.; de Bruin, Esther; Althaus, Monika; Verheij, Fop; Ferdinand, Robert F.

    2008-01-01

    Previous studies indicate that Multiple Complex Developmental Disorder (MCDD) children differ from PDD-NOS and autistic children on a symptom level and on psychophysiological functioning. Children with MCDD (n = 21) and PDD-NOS (n = 62) were compared on two facets of social-cognitive functioning: identification of neutral faces and facial…

  10. 78 FR 32622 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... National Oceanic and Atmospheric Administration RIN 0648-XC703 Endangered Species; File Nos. 17557 and... National Ocean Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No... Colligan], 1 Blackburn Drive, Gloucester, MA 01930 (File No. 17273), have applied in due form for...

  11. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  12. Multiple Complex Developmental Disorder Delineated from PDD-NOS

    ERIC Educational Resources Information Center

    de Bruin, Esther I.; de Nijs, Pieter F. A.; Verheij, Fop; Hartman, Catharina A.; Ferdinand, Robert F.

    2007-01-01

    The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6-12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity,…

  13. Magnetic circular dichroism spectroscopic characterization of the NOS-like protein from Geobacillus stearothermophilus (gsNOS).

    PubMed

    Kinloch, Ryan D; Sono, Masanori; Sudhamsu, Jawahar; Crane, Brian R; Dawson, John H

    2010-03-01

    Nitric oxide synthase (NOS) catalyzes the NADPH- and O(2)-dependent oxidation of l-arginine (l-Arg) to nitric oxide (NO) and citrulline via an N(G)-hydroxy-l-arginine (NHA) intermediate. Mammalian NOSs have been studied quite extensively; other eukaryotes and some prokaryotes appear to express NOS-like proteins comparable to the oxygenase domain of mammalian NOSs. In this study, a recombinant NOS-like protein from the thermostable bacterium Geobacillus stearothermophilus (gsNOS) has been characterized using magnetic circular dichroism (MCD) and UV-Vis absorption spectroscopic techniques. Spectral comparisons of ligand complexes (with O(2), NO and CO) of substrate-bound (l-Arg or NHA) gsNOS, including the key oxyferrous complex studied at -50 degrees C in cryogenic mixed solvents, with analogous mammalian NOS complexes indicate overall spectroscopic similarities between gsNOS and mammalian NOSs. However, more detailed spectral comparisons reflect subtle structural differences between gsNOS and mammalian NOSs. This may be due to an incomplete tetrahydrobiopterin (BH(4))-binding site and low BH(4)-binding affinity, which may become even lower in the presence of cryosolvent in gsNOS. Although BH(4)-binding may be altered, gsNOS appears to require the pterin for NO production since formation of the stable ferric-NO product complex was only observed when excess BH(4) (>150muM) over gsNOS was present upon single turnover reaction in which O(2) was bubbled into dithionite-reduced NHA-bound protein solution at -35 degrees C or -50 degrees C. PMID:20110129

  14. Vascular nitric oxide: Beyond eNOS.

    PubMed

    Zhao, Yingzi; Vanhoutte, Paul M; Leung, Susan W S

    2015-10-01

    As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis. PMID:26499181

  15. Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts

    PubMed Central

    Roselló-Lletí, Esther; Tarazón, Estefanía; Ortega, Ana; Gil-Cayuela, Carolina; Carnicer, Ricardo; Lago, Francisca; González-Juanatey, Jose Ramón; Portolés, Manuel; Rivera, Miguel

    2016-01-01

    An essential factor for the production of nitric oxide by nitric oxide synthase 1 (NOS1), major modulator of cardiac function, is the cofactor tetrahydrobiopterin (BH4). BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses the formation of dihydroneopterin 3′triphosfate from GTP, producing BH4 after two further steps catalyzed by 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. However, there are other essential factors involved in the regulation of NOS1 activity, such as protein inhibitor of NOS1 (PIN), calmodulin, heat shock protein 90, and NOS interacting protein. All these molecules have never been analysed in human non-ischemic dilated hearts (DCM). In this study we demonstrated that the upregulation of cardiac NOS1 is not accompanied by increased NOS1 activity in DCM, partly due to the elevated PIN levels and not because of alterations in biopterin biosynthesis. Notably, the PIN concentration was significantly associated with impaired ventricular function, highlighting the importance of this NOS1 activity inhibitor in Ca2+ homeostasis. These results take a central role in the current list of targets for future studies focused on the complex cardiac dysfunction processes through more efficient harnessing of NOS1 signalling. PMID:27481317

  16. Advancing the Perceptions of the Nature of Science (NOS): Integrating Teaching the NOS in a Science Content Course

    ERIC Educational Resources Information Center

    Aflalo, Ester

    2014-01-01

    Background: Understanding the nature of science (NOS) has been a key objective in teaching sciences for many years. Despite the importance of this goal it is, until this day, a complex challenge that we are far from achieving. Purpose: The study was conducted in order to further the understanding of the NOS amongst preservice teachers. It explores…

  17. 48 CFR 6101.2 - Filing cases; time limits for filing; notice of docketing; consolidation [Rule 2].

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Filing cases; time limits... Filing cases; time limits for filing; notice of docketing; consolidation . (a) Filing cases. Filing of a... machine number, and e-mail address, if available, of the contracting officer whose decision is...

  18. 48 CFR 6101.2 - Filing cases; time limits for filing; notice of docketing; consolidation [Rule 2].

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Filing cases; time limits... Filing cases; time limits for filing; notice of docketing; consolidation . (a) Filing cases. Filing of a... machine number, and e-mail address, if available, of the contracting officer whose decision is...

  19. 48 CFR 6101.2 - Filing cases; time limits for filing; notice of docketing; consolidation [Rule 2].

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Filing cases; time limits... Filing cases; time limits for filing; notice of docketing; consolidation . (a) Filing cases. Filing of a... machine number, and e-mail address, if available, of the contracting officer whose decision is...

  20. 48 CFR 6101.2 - Filing cases; time limits for filing; notice of docketing; consolidation [Rule 2].

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Filing cases; time limits... Filing cases; time limits for filing; notice of docketing; consolidation . (a) Filing cases. Filing of a... machine number, and e-mail address, if available, of the contracting officer whose decision is...

  1. 21 CFR 10.20 - Submission of documents to Division of Dockets Management; computation of time; availability for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Management; computation of time; availability for public disclosure. 10.20 Section 10.20 Food and Drugs FOOD... Management; computation of time; availability for public disclosure. (a) A submission to the Division of Dockets Management of a petition, comment, objection, notice, compilation of information, or any...

  2. 10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Cfr Part 52 § 2.621 Acceptance and docketing of application for early review of site suitability... of site suitability issues in a combined license proceeding. 2.621 Section 2.621 Energy NUCLEAR... Procedures Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an...

  3. 76 FR 9612 - GE Hitachi Nuclear Energy; Acceptance for Docketing of an Application for Renewal of the U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION GE Hitachi Nuclear Energy; Acceptance for Docketing of an Application for Renewal of the U.S. Advanced Boiling Water Reactor Design Certification On December 7, 2010, GE Hitachi Nuclear Energy (GEH) submitted an application to the U.S....

  4. 75 FR 80854 - Toshiba Corporation; Acceptance for Docketing of an Application for Renewal of the U.S. Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... availability of this application was previously published in the Federal Register (75 FR 71744) on November 24... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Toshiba Corporation; Acceptance for Docketing of an Application for Renewal of the U.S....

  5. 75 FR 33653 - Exelon Nuclear Texas Holdings, LLC (Exelon) Acceptance for Docketing of an Application for an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... was previously published in the Federal Register (75 FR 22434: April 28, 2010). The applicant... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Exelon Nuclear Texas Holdings, LLC (Exelon) Acceptance for Docketing of an Application for...

  6. 10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... processing, the Director of the Office of New Reactors or the Director of the Office of Nuclear Reactor... Nuclear Reactor Regulation, as appropriate, that they are complete. (c) If part one of the application is docketed, the Director of the Office of New Reactors or the Director of the Office of Nuclear...

  7. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for Litigation. 406.113 Section 406.113 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT...

  8. 10 CFR 2.603 - Acceptance and docketing of application for early review of site suitability issues in a...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Acceptance and docketing of application for early review of site suitability issues in a construction permit proceeding. 2.603 Section 2.603 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Additional Procedures Applicable to Early...

  9. 10 CFR 2.621 - Acceptance and docketing of application for early review of site suitability issues in a combined...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Acceptance and docketing of application for early review of site suitability issues in a combined license proceeding. 2.621 Section 2.621 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Additional Procedures Applicable to Early...

  10. 75 FR 43566 - University of Maryland; Notice of Acceptance for Docketing and Opportunity for Hearing on the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION University of Maryland; Notice of Acceptance for Docketing and Opportunity for Hearing on the Application Regarding Renewal of Facility Operating License for an Additional 20-Year Period for the Maryland University Training Reactor and...

  11. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for Litigation. 406.113 Section 406.113 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

  12. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for Litigation. 406.113 Section 406.113 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

  13. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for Litigation. 406.113 Section 406.113 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT...

  14. 14 CFR 406.113 - Filing documents with the Docket Management System (DMS) and sending documents to the...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Filing documents with the Docket Management System (DMS) and sending documents to the administrative law judge and Assistant Chief Counsel for Litigation. 406.113 Section 406.113 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

  15. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling

    PubMed Central

    Förstermann, Ulrich; Li, Huige

    2011-01-01

    Nitric oxide (NO) produced by the endothelium is an important protective molecule in the vasculature. It is generated by the enzyme endothelial NO synthase (eNOS). Similar to all NOS isoforms, functional eNOS transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH), via the flavins flavin adenine dinucleotide and flavin mononucleotide in the carboxy-terminal reductase domain, to the heme in the amino-terminal oxygenase domain. Here, the substrate L-arginine is oxidized to L-citrulline and NO. Cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolaemia or cigarette smoking reduce bioactive NO. These risk factors lead to an enhanced production of reactive oxygen species (ROS) in the vessel wall. NADPH oxidases represent major sources of this ROS and have been found upregulated in the presence of cardiovascular risk factors. NADPH-oxidase-derived superoxide avidly reacts with eNOS-derived NO to form peroxynitrite (ONOO-). The essential NOS cofactor (6R-)5,6,7,8-tetrahydrobiopterin (BH4) is highly sensitive to oxidation by this ONOO-. In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting NOS to a superoxide-producing enzyme. Among conventional drugs, compounds interfering with the renin-angiotensin-aldosterone system and statins can reduce vascular oxidative stress and increase bioactive NO. In recent years, we have identified a number of small molecules that have the potential to prevent eNOS uncoupling and, at the same time, enhance eNOS expression. These include the protein kinase C inhibitor midostaurin, the pentacyclic triterpenoids ursolic acid and betulinic acid, the eNOS enhancing compounds AVE9488 and AVE3085, and the polyphenolic phytoalexin trans-resveratrol. Such compounds enhance NO production from eNOS also under pathophysiological conditions and may thus have therapeutic potential. PMID:21198553

  16. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions About Using History of Science to Teach NOS

    NASA Astrophysics Data System (ADS)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-05-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing biology teachers' understanding of NOS, and their perceptions about using HOS to teach NOS. These teachers ( N = 8), enrolled in a professional development program in Chile are, according to the national curriculum, expected to teach NOS, but have no specific NOS and HOS training. Teachers' views of NOS were assessed using the VNOS-D+ questionnaire at the beginning and at the end of two modules about science instruction and NOS. Both the pre- and the post-test were accompanied by interviews, and in the second session we collected information about teachers' perceptions of which interventions had been more significant in changing their views on NOS. Finally, the teachers also had to prepare a lesson plan for teaching NOS that included HOS. Some of the most important study results were: significant improvements were observed in teachers' understanding of NOS, although they assigned different levels of importance to HOS in these improvements; and although the teachers improved their understanding of NOS, most had difficulties in planning lessons about NOS and articulating historical episodes that incorporated NOS. The relationship between teachers' improved understanding of NOS and their instructional NOS skills is also discussed.

  17. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury

    PubMed Central

    Filipczak, Piotr T.; Senft, Albert P.; Seagrave, JeanClare; Weber, Waylon; Kuehl, Philip J.; Fredenburgh, Laura E.; McDonald, Jacob D.; Baron, Rebecca M.

    2015-01-01

    Phosgene exposure via an industrial or warfare release produces severe acute lung injury (ALI) with high mortality, characterized by massive pulmonary edema, disruption of epithelial tight junctions, surfactant dysfunction, and oxidative stress. There are no targeted treatments for phosgene-induced ALI. Previous studies demonstrated that nitric oxide synthase 2 (NOS-2) is upregulated in the lungs after phosgene exposure; however, the role of NOS-2 in the pathogenesis of phosgene-induced ALI remains unknown. We previously demonstrated that NOS-2 expression in lung epithelium exacerbates inhaled endotoxin-induced ALI in mice, mediated partially through downregulation of surfactant protein B (SP-B) expression. Therefore, we hypothesized that a selective NOS-2 inhibitor delivered to the lung epithelium by inhalation would mitigate phosgene-induced ALI. Inhaled phosgene produced increases in bronchoalveolar lavage fluid protein, histologic lung injury, and lung NOS-2 expression at 24 h. Administration of the selective NOS-2 inhibitor 1400 W via inhalation, but not via systemic delivery, significantly attenuated phosgene-induced ALI and preserved epithelial barrier integrity. Furthermore, aerosolized 1400 W augmented expression of SP-B and prevented downregulation of tight junction protein zonula occludens 1 (ZO-1), both critical for maintenance of normal lung physiology and barrier integrity. We also demonstrate for the first time that NOS-2-derived nitric oxide downregulates the ZO-1 expression at the transcriptional level in human lung epithelial cells, providing a novel target for ameliorating vascular leak in ALI. Our data demonstrate that lung NOS-2 plays a critical role in the development of phosgene-induced ALI and suggest that aerosolized NOS-2 inhibitors offer a novel therapeutic strategy for its treatment. PMID:25870319

  18. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    PubMed

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p < 0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p < 0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies. PMID:27277302

  19. Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.

    PubMed

    Chan, J Y; Wang, S H; Chan, S H

    2001-01-01

    We investigated the differential contribution of inducible and neuronal nitric oxide synthase (iNOS and nNOS) at the rostral ventrolateral medulla (RVLM) to endotoxemia induced by E. coli lipopolysaccharide (LPS). In Sprague-Dawley rats maintained under propofol anesthesia, i.v. administration of LPS (15, 30, or 45 mg/kg) induced a reduction (phase I), followed by an augmentation (phase II) and a secondary decrease (phase III) in the power density of the vasomotor components (0-0.8 Hz) in systemic arterial pressure (SAP) signals. LPS also induced an immediate hypotension, followed by a rebound increase and a secondary decrease in SAP. In addition, the level of iNOS mRNA exhibited a significant surge that began with phase I endotoxemia, reaching progressively its peak at phase III. Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia. Pretreatment with microinjection of the selective iNOS inhibitor, aminoguanidine (250 pmol), into the bilateral RVLM significantly prolonged phases II and III endotoxemia, blunted the initial and secondary hypotension, and antagonized the upregulation of iNOS mRNA. Similar pretreatment with the selective nNOS inhibitor, 7-nitroindazole (1 pmol), on the other hand, discernibly shortened phase II and prolonged phase III endotoxemia, and induced progressive hypotension by antagonizing the rebound increase in SAP. We conclude that the relative prevalence of functional expression and molecular synthesis of iNOS over nNOS in the RVLM may be a crucial determinant for the reduction or loss in power density of the vasomotor components of SAP signals during experimental endotoxemia. PMID:11198360

  20. Vault Area (original section), east corridor, looking north (Vault Nos. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Vault Area (original section), east corridor, looking north (Vault Nos. 1-9 - Fort McNair, Film Store House, Fort Lesley J. McNair, P Street between Third & Fourth Streets, Southwest, Washington, District of Columbia, DC

  1. 78 FR 50395 - Endangered Species; File Nos. 17557 and 17273

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... INFORMATION: On May 31, 2013, notice was published in the Federal Register (78 FR 32622) that requests for a... Service Marine Forensic Lab (NOS Lab) , 219 Fort Johnson Road, Charleston, SC 29412 (File No. 17557),...

  2. FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2122 AND 2124 ON THE WEST SIDE OF UBER STREET, LOOKING WEST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  3. FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT ELEVATIONS, NOS. 2123 AND 2125 ON THE EAST SIDE OF UBER STREET, LOOKING EAST. - 2100 Block North Uber Street (Houses), East & west sides between Diamond Street & Susquehanna Avenue, Philadelphia, Philadelphia County, PA

  4. Los Angeles County Poor Farm, Patient Ward Nos. 210 & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Los Angeles County Poor Farm, Patient Ward Nos. 210 & 211 - Type B Plan, 7601 Imperial Highway; bounded by Esperanza Street, Laurel Street, Flores Street, and Descanso Street, Downey, Los Angeles County, CA

  5. 37. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH SPECIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH SPECIAL HORIZONTAL SAMSON TURBINE (RIVITED CASE) - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  6. 36. ISLAND PLANT: Nos. 1 AND 2 TWENTYSIX INCH HORIZONTAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. ISLAND PLANT: Nos. 1 AND 2 TWENTY-SIX INCH HORIZONTAL SAMSON TURBINES - American Falls Water, Power & Light Company, Island Power Plant, Snake River, below American Falls Dam, American Falls, Power County, ID

  7. Interior of Left Powerhouse showing generator Nos. 14. This view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior of Left Powerhouse showing generator Nos. 1-4. This view is from the catwalk at the level of the overhead crane, looking west. - Columbia Basin Project, Grand Coulee Dam Powerplant Complex, Grand Coulee, Grant County, WA

  8. eNOS-uncoupling in age-related erectile dysfunction

    PubMed Central

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ‘young’ (4-month-old) and ‘aged’ (19-month-old) rats were treated with a BH4 precursor sepiapterin (10 mg/kg intraperitoneally) or vehicle for 4 days. After 1-day washout, erectile function was assessed in response to electrical stimulation of the cavernous nerve. Endothelial dysfunction (eNOS uncoupling) and oxidative stress (thiobarbituric acid reactive substances, TBARS) were measured by conducting western blot in penes samples. Erectile response was significantly reduced in aged rats, whereas eNOS uncoupling and TBARS production were significantly increased in the aged rat penis compared with young rats. Sepiapterin significantly improved erectile response in aged rats and prevented increase in TBARS production, but did not affect eNOS uncoupling in the penis of aged rats. These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED. PMID:21289638

  9. Muscular nitric oxide synthase (muNOS) and utrophin.

    PubMed

    Chaubourt, Emmanuel; Voisin, Vincent; Fossier, Philippe; Baux, Gérard; Israël, Maurice; De La Porte, Sabine

    2002-01-01

    Duchenne muscular dystrophy (DMD), the severe X-linked recessive disorder which results in progressive muscle degeneration, is due to a lack of dystrophin, a membrane cytoskeletal protein. Three types of treatment are envisaged: pharmacological (glucocorticoid), myoblast transplantation, and gene therapy. An alternative to the pharmacological approach is to compensate for dystrophin loss by the upregulation of another cytoskeletal protein, utrophin. Utrophin and dystrophin are part of a complex of proteins and glycoproteins, which links the basal lamina to the cytoskeleton, thus ensuring the stability of the muscle membrane. One protein of the complex, syntrophin, is associated with a muscular isoform of the neuronal nitric oxide synthase (nNOS). We have demonstrated an overexpression of utrophin, visualised by immunofluorescence and quantified by Western blotting, in normal myotubes and in mdx (the animal model of DMD) myotubes, as in normal (C57) and mdx mice, both treated with nitric oxide (NO) donor or L-arginine, the NOS substrate. There is evidence that utrophin may be capable of performing the same cellular functions as dystrophin and may functionally compensate for its lack. Thus, we propose to use NO donors, as palliative treatment of Duchenne and Becker muscular dystrophies, pending, or in combination with, gene and/or cellular therapy. Discussion has focussed on the various isoforms of NOS that could be implicated in the regeneration process. Dystrophic and healthy muscles respond to treatment, suggesting that although NOS is delocalised in the cytoplasm in the case of DMD, it conserves substantial activity. eNOS present in mitochondria and iNOS present in cytoplasm and the neuromuscular junction could also be activated. Lastly, production of NO by endothelial NOS of the capillaries would also be beneficial through increased supply of metabolites and oxygen to the muscles. PMID:11755782

  10. Final evaluation & test report for the standard waste box (docket 01-53-7A) type A packaging

    SciTech Connect

    KELLY, D L

    2001-10-15

    This report documents the U.S. Department of Transportation Specification 7A Type A compliance test and evaluation results of the Standard Waste Box. Testing and evaluation activities documented herein are on behalf of the U.S. Department of Energy-Headquarters, Office of Safety, Health and Security (EM-5), Germantown, Maryland. Duratek Federal Services, Inc., Northwest Operations performed an evaluation of the changes as documented herein under Docket 01-53-7A.